id	sid	tid	token	lemma	pos
cajgh-41	1	1	editorial	editorial	NOUN
cajgh-41	1	2	:	:	PUNCT
cajgh-41	1	3	brca1	brca1	PROPN
cajgh-41	1	4	and	and	CCONJ
cajgh-41	1	5	brca2	brca2	PROPN
cajgh-41	1	6	gene	gene	NOUN
cajgh-41	1	7	mutations	mutation	NOUN
cajgh-41	1	8	screening	screen	VERB
cajgh-41	1	9	in	in	ADP
cajgh-41	1	10	sporadic	sporadic	ADJ
cajgh-41	1	11	breast	breast	NOUN
cajgh-41	1	12	cancer	cancer	NOUN
cajgh-41	1	13	patients	patient	NOUN
cajgh-41	1	14	in	in	ADP
cajgh-41	1	15	kazakhstan	kazakhstan	PROPN
cajgh-41	1	16	editorial	editorial	PROPN
cajgh-41	1	17	:	:	PUNCT
cajgh-41	1	18	brca1	brca1	PROPN
cajgh-41	1	19	and	and	CCONJ
cajgh-41	1	20	brca2	brca2	PROPN
cajgh-41	1	21	gene	gene	NOUN
cajgh-41	1	22	mutations	mutation	NOUN
cajgh-41	1	23	screening	screen	VERB
cajgh-41	1	24	in	in	ADP
cajgh-41	1	25	sporadic	sporadic	ADJ
cajgh-41	1	26	breast	breast	NOUN
cajgh-41	1	27	cancer	cancer	NOUN
cajgh-41	1	28	patients	patient	NOUN
cajgh-41	1	29	in	in	ADP
cajgh-41	1	30	kazakhstan	kazakhstan	PROPN
cajgh-41	1	31	rachel	rachel	PROPN
cajgh-41	1	32	c.	c.	PROPN
cajgh-41	1	33	jankowitz1	jankowitz1	PROPN
cajgh-41	1	34	,	,	PUNCT
cajgh-41	1	35	kelly	kelly	PROPN
cajgh-41	1	36	z.	z.	PROPN
cajgh-41	1	37	knickelbein2	knickelbein2	PROPN
cajgh-41	2	1	1university	1university	NUM
cajgh-41	2	2	of	of	ADP
cajgh-41	2	3	pittsburgh	pittsburgh	PROPN
cajgh-41	2	4	cancer	cancer	PROPN
cajgh-41	2	5	institute	institute	PROPN
cajgh-41	2	6	,	,	PUNCT
cajgh-41	2	7	upmc	upmc	PROPN
cajgh-41	2	8	magee	magee	PROPN
cajgh-41	2	9	women	women	PROPN
cajgh-41	2	10	's	's	PART
cajgh-41	2	11	cancer	cancer	NOUN
cajgh-41	2	12	program	program	NOUN
cajgh-41	2	13	;	;	PUNCT
cajgh-41	2	14	2upmc	2upmc	NUM
cajgh-41	2	15	center	center	NOUN
cajgh-41	2	16	for	for	ADP
cajgh-41	2	17	medical	medical	ADJ
cajgh-41	2	18	genetics	genetic	NOUN
cajgh-41	2	19	editorial	editorial	NOUN
cajgh-41	2	20	while	while	SCONJ
cajgh-41	2	21	the	the	DET
cajgh-41	2	22	majority	majority	NOUN
cajgh-41	2	23	of	of	ADP
cajgh-41	2	24	breast	breast	NOUN
cajgh-41	2	25	cancer	cancer	NOUN
cajgh-41	2	26	cases	case	NOUN
cajgh-41	2	27	are	be	AUX
cajgh-41	2	28	sporadic	sporadic	ADJ
cajgh-41	2	29	,	,	PUNCT
cajgh-41	2	30	up	up	ADP
cajgh-41	2	31	to	to	PART
cajgh-41	2	32	30	30	NUM
cajgh-41	2	33	%	%	NOUN
cajgh-41	2	34	have	have	AUX
cajgh-41	2	35	been	be	AUX
cajgh-41	2	36	described	describe	VERB
cajgh-41	2	37	as	as	ADP
cajgh-41	2	38	familial	familial	ADJ
cajgh-41	2	39	.	.	PUNCT
cajgh-41	3	1	hereditary	hereditary	ADJ
cajgh-41	3	2	breast	breast	NOUN
cajgh-41	3	3	cancer	cancer	NOUN
cajgh-41	3	4	,	,	PUNCT
cajgh-41	3	5	accounting	account	VERB
cajgh-41	3	6	for	for	ADP
cajgh-41	3	7	approximately	approximately	ADV
cajgh-41	3	8	10	10	NUM
cajgh-41	3	9	%	%	NOUN
cajgh-41	3	10	of	of	ADP
cajgh-41	3	11	breast	breast	NOUN
cajgh-41	3	12	cancer	cancer	NOUN
cajgh-41	3	13	cases	case	NOUN
cajgh-41	3	14	,	,	PUNCT
cajgh-41	3	15	has	have	AUX
cajgh-41	3	16	classically	classically	ADV
cajgh-41	3	17	been	be	AUX
cajgh-41	3	18	associated	associate	VERB
cajgh-41	3	19	with	with	ADP
cajgh-41	3	20	highly	highly	ADV
cajgh-41	3	21	penetrant	penetrant	ADJ
cajgh-41	3	22	gene	gene	NOUN
cajgh-41	3	23	mutations	mutation	NOUN
cajgh-41	3	24	that	that	PRON
cajgh-41	3	25	are	be	AUX
cajgh-41	3	26	highly	highly	ADV
cajgh-41	3	27	likely	likely	ADJ
cajgh-41	3	28	to	to	PART
cajgh-41	3	29	cause	cause	VERB
cajgh-41	3	30	cancer	cancer	NOUN
cajgh-41	3	31	,	,	PUNCT
cajgh-41	3	32	vertical	vertical	ADJ
cajgh-41	3	33	transmission	transmission	NOUN
cajgh-41	3	34	,	,	PUNCT
cajgh-41	3	35	autosomal	autosomal	ADJ
cajgh-41	3	36	dominant	dominant	ADJ
cajgh-41	3	37	inheritance	inheritance	NOUN
cajgh-41	3	38	pattern	pattern	NOUN
cajgh-41	3	39	,	,	PUNCT
cajgh-41	3	40	association	association	NOUN
cajgh-41	3	41	with	with	ADP
cajgh-41	3	42	other	other	ADJ
cajgh-41	3	43	cancers	cancer	NOUN
cajgh-41	3	44	,	,	PUNCT
cajgh-41	3	45	and	and	CCONJ
cajgh-41	3	46	early	early	ADJ
cajgh-41	3	47	age	age	NOUN
cajgh-41	3	48	of	of	ADP
cajgh-41	3	49	onset.1	onset.1	NOUN
cajgh-41	3	50	-	-	PUNCT
cajgh-41	3	51	5	5	NUM
cajgh-41	3	52	in	in	ADP
cajgh-41	3	53	contrast	contrast	NOUN
cajgh-41	3	54	,	,	PUNCT
cajgh-41	3	55	these	these	DET
cajgh-41	3	56	characteristics	characteristic	NOUN
cajgh-41	3	57	are	be	AUX
cajgh-41	3	58	often	often	ADV
cajgh-41	3	59	not	not	PART
cajgh-41	3	60	exhibited	exhibit	VERB
cajgh-41	3	61	in	in	ADP
cajgh-41	3	62	familial	familial	ADJ
cajgh-41	3	63	breast	breast	NOUN
cajgh-41	3	64	cancers	cancer	NOUN
cajgh-41	3	65	.	.	PUNCT
cajgh-41	4	1	therefore	therefore	ADV
cajgh-41	4	2	,	,	PUNCT
cajgh-41	4	3	although	although	SCONJ
cajgh-41	4	4	familial	familial	ADJ
cajgh-41	4	5	breast	breast	NOUN
cajgh-41	4	6	cancers	cancer	NOUN
cajgh-41	4	7	occur	occur	VERB
cajgh-41	4	8	more	more	ADV
cajgh-41	4	9	in	in	ADP
cajgh-41	4	10	an	an	DET
cajgh-41	4	11	individual	individual	ADJ
cajgh-41	4	12	family	family	NOUN
cajgh-41	4	13	than	than	ADP
cajgh-41	4	14	in	in	ADP
cajgh-41	4	15	the	the	DET
cajgh-41	4	16	general	general	ADJ
cajgh-41	4	17	population	population	NOUN
cajgh-41	4	18	,	,	PUNCT
cajgh-41	4	19	they	they	PRON
cajgh-41	4	20	are	be	AUX
cajgh-41	4	21	thought	think	VERB
cajgh-41	4	22	to	to	PART
cajgh-41	4	23	be	be	AUX
cajgh-41	4	24	due	due	ADJ
cajgh-41	4	25	to	to	ADP
cajgh-41	4	26	a	a	DET
cajgh-41	4	27	complex	complex	ADJ
cajgh-41	4	28	interaction	interaction	NOUN
cajgh-41	4	29	between	between	ADP
cajgh-41	4	30	lower	low	ADJ
cajgh-41	4	31	penetrance	penetrance	NOUN
cajgh-41	4	32	genes	gene	NOUN
cajgh-41	4	33	and	and	CCONJ
cajgh-41	4	34	environmental	environmental	ADJ
cajgh-41	4	35	factors	factor	NOUN
cajgh-41	4	36	and/or	and/or	CCONJ
cajgh-41	4	37	random	random	ADJ
cajgh-41	4	38	intra	intra	ADJ
cajgh-41	4	39	-	-	ADJ
cajgh-41	4	40	familial	familial	ADJ
cajgh-41	4	41	sporadic	sporadic	ADJ
cajgh-41	4	42	cancer	cancer	NOUN
cajgh-41	4	43	cases.3	cases.3	PROPN
cajgh-41	4	44	-	-	PUNCT
cajgh-41	4	45	5	5	NUM
cajgh-41	4	46	in	in	ADP
cajgh-41	4	47	1994	1994	NUM
cajgh-41	4	48	,	,	PUNCT
cajgh-41	4	49	inherited	inherit	VERB
cajgh-41	4	50	mutations	mutation	NOUN
cajgh-41	4	51	in	in	ADP
cajgh-41	4	52	brca1	brca1	PROPN
cajgh-41	4	53	and	and	CCONJ
cajgh-41	4	54	brca2	brca2	NOUN
cajgh-41	4	55	genes	gene	NOUN
cajgh-41	4	56	that	that	PRON
cajgh-41	4	57	encode	encode	VERB
cajgh-41	4	58	for	for	ADP
cajgh-41	4	59	tumor	tumor	NOUN
cajgh-41	4	60	suppressor	suppressor	NOUN
cajgh-41	4	61	proteins	protein	NOUN
cajgh-41	4	62	were	be	AUX
cajgh-41	4	63	linked	link	VERB
cajgh-41	4	64	to	to	ADP
cajgh-41	4	65	hereditary	hereditary	ADJ
cajgh-41	4	66	breast	breast	NOUN
cajgh-41	4	67	and	and	CCONJ
cajgh-41	4	68	ovarian	ovarian	ADJ
cajgh-41	4	69	cancer.6,7	cancer.6,7	PROPN
cajgh-41	4	70	since	since	SCONJ
cajgh-41	4	71	this	this	DET
cajgh-41	4	72	groundbreaking	groundbreake	VERB
cajgh-41	4	73	scientific	scientific	ADJ
cajgh-41	4	74	discovery	discovery	NOUN
cajgh-41	4	75	,	,	PUNCT
cajgh-41	4	76	much	much	ADJ
cajgh-41	4	77	has	have	AUX
cajgh-41	4	78	been	be	AUX
cajgh-41	4	79	learned	learn	VERB
cajgh-41	4	80	about	about	ADP
cajgh-41	4	81	genetic	genetic	ADJ
cajgh-41	4	82	risk	risk	NOUN
cajgh-41	4	83	of	of	ADP
cajgh-41	4	84	breast	breast	NOUN
cajgh-41	4	85	cancer	cancer	NOUN
cajgh-41	4	86	(	(	PUNCT
cajgh-41	4	87	such	such	ADJ
cajgh-41	4	88	as	as	ADP
cajgh-41	4	89	newer	new	ADJ
cajgh-41	4	90	detection	detection	NOUN
cajgh-41	4	91	techniques	technique	NOUN
cajgh-41	4	92	with	with	ADP
cajgh-41	4	93	improved	improved	ADJ
cajgh-41	4	94	sensitivity	sensitivity	NOUN
cajgh-41	4	95	to	to	PART
cajgh-41	4	96	detect	detect	VERB
cajgh-41	4	97	brca1	brca1	PROPN
cajgh-41	4	98	and	and	CCONJ
cajgh-41	4	99	brca2	brca2	PROPN
cajgh-41	4	100	large	large	ADJ
cajgh-41	4	101	genomic	genomic	NOUN
cajgh-41	4	102	rearrangements);8	rearrangements);8	PROPN
cajgh-41	4	103	however	however	ADV
cajgh-41	4	104	,	,	PUNCT
cajgh-41	4	105	many	many	ADJ
cajgh-41	4	106	brca	brca	PROPN
cajgh-41	4	107	-	-	PUNCT
cajgh-41	4	108	related	relate	VERB
cajgh-41	4	109	questions	question	NOUN
cajgh-41	4	110	remain	remain	VERB
cajgh-41	4	111	unanswered	unanswered	ADJ
cajgh-41	4	112	.	.	PUNCT
cajgh-41	5	1	the	the	DET
cajgh-41	5	2	prevalence	prevalence	NOUN
cajgh-41	5	3	of	of	ADP
cajgh-41	5	4	known	know	VERB
cajgh-41	5	5	deleterious	deleterious	ADJ
cajgh-41	5	6	brca1	brca1	NOUN
cajgh-41	5	7	and	and	CCONJ
cajgh-41	5	8	brca2	brca2	PROPN
cajgh-41	5	9	gene	gene	NOUN
cajgh-41	5	10	mutations	mutation	NOUN
cajgh-41	5	11	is	be	AUX
cajgh-41	5	12	approximately	approximately	ADV
cajgh-41	5	13	1	1	NUM
cajgh-41	5	14	in	in	ADP
cajgh-41	5	15	400	400	NUM
cajgh-41	5	16	individuals.9	individuals.9	ADJ
cajgh-41	5	17	due	due	ADP
cajgh-41	5	18	to	to	ADP
cajgh-41	5	19	variable	variable	ADJ
cajgh-41	5	20	penetrance	penetrance	NOUN
cajgh-41	5	21	,	,	PUNCT
cajgh-41	5	22	the	the	DET
cajgh-41	5	23	probability	probability	NOUN
cajgh-41	5	24	of	of	ADP
cajgh-41	5	25	cancer	cancer	NOUN
cajgh-41	5	26	development	development	NOUN
cajgh-41	5	27	varies	vary	VERB
cajgh-41	5	28	amongst	amongst	ADP
cajgh-41	5	29	brca	brca	PROPN
cajgh-41	5	30	mutation	mutation	NOUN
cajgh-41	5	31	carriers	carrier	NOUN
cajgh-41	5	32	,	,	PUNCT
cajgh-41	5	33	(	(	PUNCT
cajgh-41	5	34	even	even	ADV
cajgh-41	5	35	amongst	amongst	ADP
cajgh-41	5	36	carriers	carrier	NOUN
cajgh-41	5	37	in	in	ADP
cajgh-41	5	38	families	family	NOUN
cajgh-41	5	39	with	with	ADP
cajgh-41	5	40	the	the	DET
cajgh-41	5	41	same	same	ADJ
cajgh-41	5	42	mutation),10	mutation),10	NOUN
cajgh-41	5	43	but	but	CCONJ
cajgh-41	5	44	in	in	ADP
cajgh-41	5	45	general	general	ADJ
cajgh-41	5	46	,	,	PUNCT
cajgh-41	5	47	brca	brca	PROPN
cajgh-41	5	48	deleterious	deleterious	ADJ
cajgh-41	5	49	mutations	mutation	NOUN
cajgh-41	5	50	confer	confer	VERB
cajgh-41	5	51	a	a	DET
cajgh-41	5	52	45	45	NUM
cajgh-41	5	53	-	-	SYM
cajgh-41	5	54	84	84	NUM
cajgh-41	5	55	%	%	NOUN
cajgh-41	5	56	lifetime	lifetime	NOUN
cajgh-41	5	57	risk	risk	NOUN
cajgh-41	5	58	for	for	ADP
cajgh-41	5	59	breast	breast	NOUN
cajgh-41	5	60	cancer.11	cancer.11	NOUN
cajgh-41	5	61	it	it	PRON
cajgh-41	5	62	is	be	AUX
cajgh-41	5	63	,	,	PUNCT
cajgh-41	5	64	therefore	therefore	ADV
cajgh-41	5	65	,	,	PUNCT
cajgh-41	5	66	not	not	PART
cajgh-41	5	67	surprising	surprising	ADJ
cajgh-41	5	68	that	that	SCONJ
cajgh-41	5	69	known	know	VERB
cajgh-41	5	70	deleterious	deleterious	ADJ
cajgh-41	5	71	brca	brca	PROPN
cajgh-41	5	72	mutations	mutation	NOUN
cajgh-41	5	73	are	be	AUX
cajgh-41	5	74	variable	variable	ADJ
cajgh-41	5	75	across	across	ADP
cajgh-41	5	76	different	different	ADJ
cajgh-41	5	77	ethnic	ethnic	ADJ
cajgh-41	5	78	and	and	CCONJ
cajgh-41	5	79	geographic	geographic	ADJ
cajgh-41	5	80	populations	population	NOUN
cajgh-41	5	81	.	.	PUNCT
cajgh-41	6	1	moreover	moreover	ADV
cajgh-41	6	2	,	,	PUNCT
cajgh-41	6	3	founder	founder	NOUN
cajgh-41	6	4	mutations	mutation	NOUN
cajgh-41	6	5	have	have	AUX
cajgh-41	6	6	been	be	AUX
cajgh-41	6	7	identified	identify	VERB
cajgh-41	6	8	within	within	ADP
cajgh-41	6	9	ashkenzi	ashkenzi	NOUN
cajgh-41	6	10	jewish	jewish	ADJ
cajgh-41	6	11	,	,	PUNCT
cajgh-41	6	12	icelandic	icelandic	ADJ
cajgh-41	6	13	,	,	PUNCT
cajgh-41	6	14	and	and	CCONJ
cajgh-41	6	15	other	other	ADJ
cajgh-41	6	16	populations	population	NOUN
cajgh-41	6	17	.	.	PUNCT
cajgh-41	7	1	when	when	SCONJ
cajgh-41	7	2	discussing	discuss	VERB
cajgh-41	7	3	brca1	brca1	NOUN
cajgh-41	7	4	and	and	CCONJ
cajgh-41	7	5	brca2	brca2	NOUN
cajgh-41	7	6	sequence	sequence	NOUN
cajgh-41	7	7	variants	variant	NOUN
cajgh-41	7	8	,	,	PUNCT
cajgh-41	7	9	the	the	DET
cajgh-41	7	10	terminology	terminology	NOUN
cajgh-41	7	11	can	can	AUX
cajgh-41	7	12	be	be	AUX
cajgh-41	7	13	difficult	difficult	ADJ
cajgh-41	7	14	to	to	PART
cajgh-41	7	15	discern	discern	VERB
cajgh-41	7	16	.	.	PUNCT
cajgh-41	8	1	variations	variation	NOUN
cajgh-41	8	2	that	that	PRON
cajgh-41	8	3	confer	confer	VERB
cajgh-41	8	4	increased	increase	VERB
cajgh-41	8	5	cancer	cancer	NOUN
cajgh-41	8	6	risk	risk	NOUN
cajgh-41	8	7	are	be	AUX
cajgh-41	8	8	termed	term	VERB
cajgh-41	8	9	“	"	PUNCT
cajgh-41	8	10	deleterious	deleterious	ADJ
cajgh-41	8	11	mutations	mutation	NOUN
cajgh-41	8	12	,	,	PUNCT
cajgh-41	8	13	”	"	PUNCT
cajgh-41	8	14	but	but	CCONJ
cajgh-41	8	15	a	a	DET
cajgh-41	8	16	number	number	NOUN
cajgh-41	8	17	of	of	ADP
cajgh-41	8	18	other	other	ADJ
cajgh-41	8	19	changes	change	NOUN
cajgh-41	8	20	in	in	ADP
cajgh-41	8	21	brca1	brca1	PROPN
cajgh-41	8	22	and	and	CCONJ
cajgh-41	8	23	brca2	brca2	PROPN
cajgh-41	8	24	are	be	AUX
cajgh-41	8	25	rapidly	rapidly	ADV
cajgh-41	8	26	emerging	emerge	VERB
cajgh-41	8	27	,	,	PUNCT
cajgh-41	8	28	the	the	DET
cajgh-41	8	29	significance	significance	NOUN
cajgh-41	8	30	of	of	ADP
cajgh-41	8	31	which	which	PRON
cajgh-41	8	32	are	be	AUX
cajgh-41	8	33	less	less	ADV
cajgh-41	8	34	clear	clear	ADJ
cajgh-41	8	35	.	.	PUNCT
cajgh-41	9	1	it	it	PRON
cajgh-41	9	2	is	be	AUX
cajgh-41	9	3	important	important	ADJ
cajgh-41	9	4	,	,	PUNCT
cajgh-41	9	5	therefore	therefore	ADV
cajgh-41	9	6	,	,	PUNCT
cajgh-41	9	7	to	to	PART
cajgh-41	9	8	use	use	VERB
cajgh-41	9	9	consistent	consistent	ADJ
cajgh-41	9	10	language	language	NOUN
cajgh-41	9	11	when	when	SCONJ
cajgh-41	9	12	discussing	discuss	VERB
cajgh-41	9	13	such	such	ADJ
cajgh-41	9	14	findings	finding	NOUN
cajgh-41	9	15	.	.	PUNCT
cajgh-41	10	1	mutations	mutation	NOUN
cajgh-41	10	2	and	and	CCONJ
cajgh-41	10	3	polymorphisms	polymorphism	NOUN
cajgh-41	10	4	are	be	AUX
cajgh-41	10	5	both	both	PRON
cajgh-41	10	6	sequence	sequence	NOUN
cajgh-41	10	7	variants	variant	NOUN
cajgh-41	10	8	.	.	PUNCT
cajgh-41	11	1	the	the	DET
cajgh-41	11	2	term	term	NOUN
cajgh-41	11	3	“	"	PUNCT
cajgh-41	11	4	mutation	mutation	NOUN
cajgh-41	11	5	”	"	PUNCT
cajgh-41	11	6	signifies	signify	VERB
cajgh-41	11	7	any	any	DET
cajgh-41	11	8	rare	rare	ADJ
cajgh-41	11	9	deviation	deviation	NOUN
cajgh-41	11	10	in	in	ADP
cajgh-41	11	11	the	the	DET
cajgh-41	11	12	dna	dna	PROPN
cajgh-41	11	13	sequence	sequence	NOUN
cajgh-41	11	14	of	of	ADP
cajgh-41	11	15	a	a	DET
cajgh-41	11	16	gene	gene	NOUN
cajgh-41	11	17	from	from	ADP
cajgh-41	11	18	the	the	DET
cajgh-41	11	19	normal	normal	ADJ
cajgh-41	11	20	wild	wild	ADJ
cajgh-41	11	21	type	type	NOUN
cajgh-41	11	22	.	.	PUNCT
cajgh-41	12	1	polymorphisms	polymorphism	NOUN
cajgh-41	12	2	,	,	PUNCT
cajgh-41	12	3	on	on	ADP
cajgh-41	12	4	the	the	DET
cajgh-41	12	5	other	other	ADJ
cajgh-41	12	6	hand	hand	NOUN
cajgh-41	12	7	,	,	PUNCT
cajgh-41	12	8	are	be	AUX
cajgh-41	12	9	common	common	ADJ
cajgh-41	12	10	variations	variation	NOUN
cajgh-41	12	11	in	in	ADP
cajgh-41	12	12	dna	dna	PROPN
cajgh-41	12	13	that	that	PRON
cajgh-41	12	14	are	be	AUX
cajgh-41	12	15	generally	generally	ADV
cajgh-41	12	16	considered	consider	VERB
cajgh-41	12	17	to	to	PART
cajgh-41	12	18	occur	occur	VERB
cajgh-41	12	19	with	with	ADP
cajgh-41	12	20	a	a	DET
cajgh-41	12	21	frequency	frequency	NOUN
cajgh-41	12	22	greater	great	ADJ
cajgh-41	12	23	than	than	ADP
cajgh-41	12	24	1%.12	1%.12	NUM
cajgh-41	12	25	if	if	SCONJ
cajgh-41	12	26	a	a	DET
cajgh-41	12	27	polymorphism	polymorphism	NOUN
cajgh-41	12	28	is	be	AUX
cajgh-41	12	29	known	know	VERB
cajgh-41	12	30	to	to	PART
cajgh-41	12	31	be	be	AUX
cajgh-41	12	32	disease	disease	NOUN
cajgh-41	12	33	-	-	PUNCT
cajgh-41	12	34	causing	cause	VERB
cajgh-41	12	35	,	,	PUNCT
cajgh-41	12	36	then	then	ADV
cajgh-41	12	37	it	it	PRON
cajgh-41	12	38	will	will	AUX
cajgh-41	12	39	typically	typically	ADV
cajgh-41	12	40	be	be	AUX
cajgh-41	12	41	referred	refer	VERB
cajgh-41	12	42	to	to	ADP
cajgh-41	12	43	as	as	ADP
cajgh-41	12	44	a	a	DET
cajgh-41	12	45	deleterious	deleterious	ADJ
cajgh-41	12	46	mutation	mutation	NOUN
cajgh-41	12	47	,	,	PUNCT
cajgh-41	12	48	although	although	SCONJ
cajgh-41	12	49	most	most	ADJ
cajgh-41	12	50	,	,	PUNCT
cajgh-41	12	51	but	but	CCONJ
cajgh-41	12	52	not	not	PART
cajgh-41	12	53	all	all	PRON
cajgh-41	12	54	,	,	PUNCT
cajgh-41	12	55	deleterious	deleterious	ADJ
cajgh-41	12	56	mutations	mutation	NOUN
cajgh-41	12	57	are	be	AUX
cajgh-41	12	58	seen	see	VERB
cajgh-41	12	59	at	at	ADP
cajgh-41	12	60	a	a	DET
cajgh-41	12	61	lower	low	ADJ
cajgh-41	12	62	frequency	frequency	NOUN
cajgh-41	12	63	in	in	ADP
cajgh-41	12	64	the	the	DET
cajgh-41	12	65	population	population	NOUN
cajgh-41	12	66	.	.	PUNCT
cajgh-41	13	1	polymorphisms	polymorphism	NOUN
cajgh-41	13	2	include	include	VERB
cajgh-41	13	3	,	,	PUNCT
cajgh-41	13	4	but	but	CCONJ
cajgh-41	13	5	are	be	AUX
cajgh-41	13	6	not	not	PART
cajgh-41	13	7	limited	limit	VERB
cajgh-41	13	8	to	to	ADP
cajgh-41	13	9	:	:	PUNCT
cajgh-41	13	10	single	single	ADJ
cajgh-41	13	11	nucleotide	nucleotide	ADJ
cajgh-41	13	12	polymorphisms	polymorphism	NOUN
cajgh-41	13	13	(	(	PUNCT
cajgh-41	13	14	snps	snps	PROPN
cajgh-41	13	15	)	)	PUNCT
cajgh-41	13	16	,	,	PUNCT
cajgh-41	13	17	insertions	insertion	NOUN
cajgh-41	13	18	,	,	PUNCT
cajgh-41	13	19	deletions	deletion	NOUN
cajgh-41	13	20	,	,	PUNCT
cajgh-41	13	21	or	or	CCONJ
cajgh-41	13	22	repeated	repeat	VERB
cajgh-41	13	23	sequences	sequence	NOUN
cajgh-41	13	24	.	.	PUNCT
cajgh-41	14	1	snps	snps	PROPN
cajgh-41	14	2	are	be	AUX
cajgh-41	14	3	the	the	DET
cajgh-41	14	4	most	most	ADV
cajgh-41	14	5	common	common	ADJ
cajgh-41	14	6	type	type	NOUN
cajgh-41	14	7	of	of	ADP
cajgh-41	14	8	polymorphism	polymorphism	NOUN
cajgh-41	14	9	accounting	account	VERB
cajgh-41	14	10	for	for	ADP
cajgh-41	14	11	approximately	approximately	ADV
cajgh-41	14	12	90	90	NUM
cajgh-41	14	13	%	%	NOUN
cajgh-41	14	14	of	of	ADP
cajgh-41	14	15	all	all	DET
cajgh-41	14	16	human	human	ADJ
cajgh-41	14	17	genetic	genetic	ADJ
cajgh-41	14	18	variation.13	variation.13	NOUN
cajgh-41	14	19	most	most	ADJ
cajgh-41	14	20	snps	snps	PROPN
cajgh-41	14	21	are	be	AUX
cajgh-41	14	22	benign	benign	ADJ
cajgh-41	14	23	or	or	CCONJ
cajgh-41	14	24	neutral	neutral	ADJ
cajgh-41	14	25	polymorphisms	polymorphism	NOUN
cajgh-41	14	26	with	with	ADP
cajgh-41	14	27	no	no	DET
cajgh-41	14	28	known	know	VERB
cajgh-41	14	29	clinical	clinical	ADJ
cajgh-41	14	30	impact	impact	NOUN
cajgh-41	14	31	;	;	PUNCT
cajgh-41	14	32	however	however	ADV
cajgh-41	14	33	,	,	PUNCT
cajgh-41	14	34	it	it	PRON
cajgh-41	14	35	is	be	AUX
cajgh-41	14	36	thought	think	VERB
cajgh-41	14	37	that	that	SCONJ
cajgh-41	14	38	some	some	PRON
cajgh-41	14	39	may	may	AUX
cajgh-41	14	40	provide	provide	VERB
cajgh-41	14	41	useful	useful	ADJ
cajgh-41	14	42	clinical	clinical	ADJ
cajgh-41	14	43	information	information	NOUN
cajgh-41	14	44	,	,	PUNCT
cajgh-41	14	45	such	such	ADJ
cajgh-41	14	46	as	as	ADP
cajgh-41	14	47	likelihood	likelihood	NOUN
cajgh-41	14	48	of	of	ADP
cajgh-41	14	49	developing	develop	VERB
cajgh-41	14	50	disease	disease	NOUN
cajgh-41	14	51	,	,	PUNCT
cajgh-41	14	52	response	response	NOUN
cajgh-41	14	53	to	to	ADP
cajgh-41	14	54	disease	disease	NOUN
cajgh-41	14	55	,	,	PUNCT
cajgh-41	14	56	and	and	CCONJ
cajgh-41	14	57	perhaps	perhaps	ADV
cajgh-41	14	58	implications	implication	NOUN
cajgh-41	14	59	for	for	ADP
cajgh-41	14	60	treatment.14	treatment.14	NOUN
cajgh-41	14	61	polymorphisms	polymorphism	NOUN
cajgh-41	14	62	and	and	CCONJ
cajgh-41	14	63	mutations	mutation	NOUN
cajgh-41	14	64	can	can	AUX
cajgh-41	14	65	be	be	AUX
cajgh-41	14	66	further	far	ADV
cajgh-41	14	67	classified	classify	VERB
cajgh-41	14	68	as	as	ADP
cajgh-41	14	69	synonymous	synonymous	ADJ
cajgh-41	14	70	or	or	CCONJ
cajgh-41	14	71	non	non	ADJ
cajgh-41	14	72	-	-	ADJ
cajgh-41	14	73	synonymous	synonymous	ADJ
cajgh-41	14	74	based	base	VERB
cajgh-41	14	75	on	on	ADP
cajgh-41	14	76	their	their	PRON
cajgh-41	14	77	impact	impact	NOUN
cajgh-41	14	78	on	on	ADP
cajgh-41	14	79	the	the	DET
cajgh-41	14	80	resulting	result	VERB
cajgh-41	14	81	amino	amino	NOUN
cajgh-41	14	82	acid	acid	NOUN
cajgh-41	14	83	.	.	PUNCT
cajgh-41	15	1	a	a	DET
cajgh-41	15	2	synonymous	synonymous	ADJ
cajgh-41	15	3	substitution	substitution	NOUN
cajgh-41	15	4	results	result	NOUN
cajgh-41	15	5	in	in	ADP
cajgh-41	15	6	a	a	DET
cajgh-41	15	7	codon	codon	NOUN
cajgh-41	15	8	that	that	PRON
cajgh-41	15	9	does	do	AUX
cajgh-41	15	10	not	not	PART
cajgh-41	15	11	lead	lead	VERB
cajgh-41	15	12	to	to	ADP
cajgh-41	15	13	a	a	DET
cajgh-41	15	14	change	change	NOUN
cajgh-41	15	15	in	in	ADP
cajgh-41	15	16	the	the	DET
cajgh-41	15	17	coded	code	VERB
cajgh-41	15	18	amino	amino	NOUN
cajgh-41	15	19	acid	acid	NOUN
cajgh-41	15	20	,	,	PUNCT
cajgh-41	15	21	whereas	whereas	SCONJ
cajgh-41	15	22	non	non	ADJ
cajgh-41	15	23	-	-	ADJ
cajgh-41	15	24	synonymous	synonymous	ADJ
cajgh-41	15	25	substitutions	substitution	NOUN
cajgh-41	15	26	,	,	PUNCT
cajgh-41	15	27	such	such	ADJ
cajgh-41	15	28	as	as	ADP
cajgh-41	15	29	missense	missense	NOUN
cajgh-41	15	30	mutations	mutation	NOUN
cajgh-41	15	31	,	,	PUNCT
cajgh-41	15	32	do	do	AUX
cajgh-41	15	33	result	result	VERB
cajgh-41	15	34	in	in	ADP
cajgh-41	15	35	an	an	DET
cajgh-41	15	36	amino	amino	NOUN
cajgh-41	15	37	acid	acid	NOUN
cajgh-41	15	38	change	change	NOUN
cajgh-41	15	39	.	.	PUNCT
cajgh-41	16	1	lastly	lastly	ADV
cajgh-41	16	2	,	,	PUNCT
cajgh-41	16	3	variants	variant	NOUN
cajgh-41	16	4	of	of	ADP
cajgh-41	16	5	uncertain	uncertain	ADJ
cajgh-41	16	6	significance	significance	NOUN
cajgh-41	16	7	(	(	PUNCT
cajgh-41	16	8	vus	vus	NOUN
cajgh-41	16	9	)	)	PUNCT
cajgh-41	16	10	are	be	AUX
cajgh-41	16	11	novel	novel	ADJ
cajgh-41	16	12	dna	dna	NOUN
cajgh-41	16	13	changes	change	NOUN
cajgh-41	16	14	with	with	ADP
cajgh-41	16	15	unknown	unknown	ADJ
cajgh-41	16	16	effects	effect	NOUN
cajgh-41	16	17	on	on	ADP
cajgh-41	16	18	protein	protein	NOUN
cajgh-41	16	19	function	function	NOUN
cajgh-41	16	20	and	and	CCONJ
cajgh-41	16	21	disease	disease	NOUN
cajgh-41	16	22	risk	risk	NOUN
cajgh-41	16	23	.	.	PUNCT
cajgh-41	17	1	pending	pende	VERB
cajgh-41	17	2	further	further	ADJ
cajgh-41	17	3	investigation	investigation	NOUN
cajgh-41	17	4	,	,	PUNCT
cajgh-41	17	5	an	an	DET
cajgh-41	17	6	identified	identify	VERB
cajgh-41	17	7	vus	vus	NOUN
cajgh-41	17	8	could	could	AUX
cajgh-41	17	9	be	be	AUX
cajgh-41	17	10	reclassified	reclassify	VERB
cajgh-41	17	11	as	as	ADP
cajgh-41	17	12	a	a	DET
cajgh-41	17	13	deleterious	deleterious	ADJ
cajgh-41	17	14	mutation	mutation	NOUN
cajgh-41	17	15	or	or	CCONJ
cajgh-41	17	16	a	a	DET
cajgh-41	17	17	polymorphism	polymorphism	NOUN
cajgh-41	17	18	of	of	ADP
cajgh-41	17	19	no	no	DET
cajgh-41	17	20	clinical	clinical	ADJ
cajgh-41	17	21	significance	significance	NOUN
cajgh-41	17	22	in	in	ADP
cajgh-41	17	23	the	the	DET
cajgh-41	17	24	future.15	future.15	NOUN
cajgh-41	17	25	in	in	ADP
cajgh-41	17	26	the	the	DET
cajgh-41	17	27	current	current	ADJ
cajgh-41	17	28	publication	publication	NOUN
cajgh-41	17	29	,	,	PUNCT
cajgh-41	17	30	akilzhanova	akilzhanova	PROPN
cajgh-41	17	31	and	and	CCONJ
cajgh-41	17	32	colleagues	colleague	NOUN
cajgh-41	17	33	examine	examine	VERB
cajgh-41	17	34	the	the	DET
cajgh-41	17	35	role	role	NOUN
cajgh-41	17	36	of	of	ADP
cajgh-41	17	37	brca1	brca1	PROPN
cajgh-41	17	38	and	and	CCONJ
cajgh-41	17	39	2	2	NUM
cajgh-41	17	40	mutations	mutation	NOUN
cajgh-41	17	41	in	in	ADP
cajgh-41	17	42	kazakhstan	kazakhstan	PROPN
cajgh-41	17	43	women	woman	NOUN
cajgh-41	17	44	with	with	ADP
cajgh-41	17	45	sporadic	sporadic	ADJ
cajgh-41	17	46	breast	breast	NOUN
cajgh-41	17	47	cancer	cancer	NOUN
cajgh-41	17	48	.	.	PUNCT
cajgh-41	18	1	they	they	PRON
cajgh-41	18	2	studied	study	VERB
cajgh-41	18	3	genomic	genomic	ADJ
cajgh-41	18	4	dna	dna	NOUN
cajgh-41	18	5	from	from	ADP
cajgh-41	18	6	156	156	NUM
cajgh-41	18	7	sporadic	sporadic	ADJ
cajgh-41	18	8	breast	breast	NOUN
cajgh-41	18	9	cancer	cancer	NOUN
cajgh-41	18	10	cases	case	NOUN
cajgh-41	18	11	(	(	PUNCT
cajgh-41	18	12	defined	define	VERB
cajgh-41	18	13	as	as	ADP
cajgh-41	18	14	women	woman	NOUN
cajgh-41	18	15	without	without	ADP
cajgh-41	18	16	family	family	NOUN
cajgh-41	18	17	history	history	NOUN
cajgh-41	18	18	of	of	ADP
cajgh-41	18	19	affected	affect	VERB
cajgh-41	18	20	firstor	firstor	NOUN
cajgh-41	18	21	seconddegree	seconddegree	ADJ
cajgh-41	18	22	relatives	relative	NOUN
cajgh-41	18	23	with	with	ADP
cajgh-41	18	24	breast	breast	NOUN
cajgh-41	18	25	and/or	and/or	CCONJ
cajgh-41	18	26	ovarian	ovarian	ADJ
cajgh-41	18	27	cancer	cancer	NOUN
cajgh-41	18	28	)	)	PUNCT
cajgh-41	18	29	and	and	CCONJ
cajgh-41	18	30	112	112	NUM
cajgh-41	18	31	controls	control	NOUN
cajgh-41	18	32	(	(	PUNCT
cajgh-41	18	33	matched	match	VERB
cajgh-41	18	34	on	on	ADP
cajgh-41	18	35	age	age	NOUN
cajgh-41	18	36	and	and	CCONJ
cajgh-41	18	37	ethnicity	ethnicity	NOUN
cajgh-41	18	38	)	)	PUNCT
cajgh-41	18	39	from	from	ADP
cajgh-41	18	40	two	two	NUM
cajgh-41	18	41	different	different	ADJ
cajgh-41	18	42	areas	area	NOUN
cajgh-41	18	43	in	in	ADP
cajgh-41	18	44	kazakhstan	kazakhstan	PROPN
cajgh-41	18	45	.	.	PUNCT
cajgh-41	19	1	ultimately	ultimately	ADV
cajgh-41	19	2	,	,	PUNCT
cajgh-41	19	3	mutational	mutational	ADJ
cajgh-41	19	4	screening	screening	NOUN
cajgh-41	19	5	of	of	ADP
cajgh-41	19	6	brca1	brca1	PROPN
cajgh-41	19	7	and	and	CCONJ
cajgh-41	19	8	brca2	brca2	PROPN
cajgh-41	19	9	coding	code	VERB
cajgh-41	19	10	regions	region	NOUN
cajgh-41	19	11	for	for	ADP
cajgh-41	19	12	these	these	DET
cajgh-41	19	13	patients	patient	NOUN
cajgh-41	19	14	and	and	CCONJ
cajgh-41	19	15	controls	control	NOUN
cajgh-41	19	16	identified	identify	VERB
cajgh-41	19	17	22	22	NUM
cajgh-41	19	18	distinct	distinct	ADJ
cajgh-41	19	19	variants	variant	NOUN
cajgh-41	19	20	(	(	PUNCT
cajgh-41	19	21	16	16	NUM
cajgh-41	19	22	missense	missense	NOUN
cajgh-41	19	23	mutations	mutation	NOUN
cajgh-41	19	24	of	of	ADP
cajgh-41	19	25	unknown	unknown	ADJ
cajgh-41	19	26	clinical	clinical	ADJ
cajgh-41	19	27	significance	significance	NOUN
cajgh-41	19	28	and	and	CCONJ
cajgh-41	19	29	6	6	NUM
cajgh-41	19	30	polymorphisms	polymorphism	NOUN
cajgh-41	19	31	)	)	PUNCT
cajgh-41	19	32	.	.	PUNCT
cajgh-41	20	1	no	no	DET
cajgh-41	20	2	deleterious	deleterious	ADJ
cajgh-41	20	3	brca1	brca1	NOUN
cajgh-41	20	4	or	or	CCONJ
cajgh-41	20	5	2	2	NUM
cajgh-41	20	6	mutations	mutation	NOUN
cajgh-41	20	7	were	be	AUX
cajgh-41	20	8	identified	identify	VERB
cajgh-41	20	9	.	.	PUNCT
cajgh-41	21	1	there	there	PRON
cajgh-41	21	2	were	be	VERB
cajgh-41	21	3	significantly	significantly	ADV
cajgh-41	21	4	more	more	ADJ
cajgh-41	21	5	variants	variant	NOUN
cajgh-41	21	6	in	in	ADP
cajgh-41	21	7	the	the	DET
cajgh-41	21	8	caucasians	caucasian	NOUN
cajgh-41	21	9	versus	versus	ADP
cajgh-41	21	10	the	the	DET
cajgh-41	21	11	asian	asian	ADJ
cajgh-41	21	12	breast	breast	NOUN
cajgh-41	21	13	cancer	cancer	NOUN
cajgh-41	21	14	cases	case	NOUN
cajgh-41	21	15	and	and	CCONJ
cajgh-41	21	16	more	more	ADJ
cajgh-41	21	17	variants	variant	NOUN
cajgh-41	21	18	in	in	ADP
cajgh-41	21	19	the	the	DET
cajgh-41	21	20	asian	asian	NOUN
cajgh-41	21	21	versus	versus	ADP
cajgh-41	21	22	the	the	DET
cajgh-41	21	23	caucasian	caucasian	ADJ
cajgh-41	21	24	controls	control	NOUN
cajgh-41	21	25	.	.	PUNCT
cajgh-41	22	1	they	they	PRON
cajgh-41	22	2	also	also	ADV
cajgh-41	22	3	found	find	VERB
cajgh-41	22	4	a	a	DET
cajgh-41	22	5	number	number	NOUN
cajgh-41	22	6	of	of	ADP
cajgh-41	22	7	women	woman	NOUN
cajgh-41	22	8	(	(	PUNCT
cajgh-41	22	9	79	79	NUM
cajgh-41	22	10	of	of	ADP
cajgh-41	22	11	156	156	NUM
cajgh-41	22	12	,	,	PUNCT
cajgh-41	22	13	71	71	NUM
cajgh-41	22	14	%	%	NOUN
cajgh-41	22	15	)	)	PUNCT
cajgh-41	22	16	who	who	PRON
cajgh-41	22	17	carried	carry	VERB
cajgh-41	22	18	4	4	NUM
cajgh-41	22	19	-	-	SYM
cajgh-41	22	20	6	6	NUM
cajgh-41	22	21	alterations	alteration	NOUN
cajgh-41	22	22	.	.	PUNCT
cajgh-41	23	1	this	this	PRON
cajgh-41	23	2	makes	make	VERB
cajgh-41	23	3	these	these	DET
cajgh-41	23	4	alterations	alteration	NOUN
cajgh-41	23	5	in	in	ADP
cajgh-41	23	6	the	the	DET
cajgh-41	23	7	brca	brca	PROPN
cajgh-41	23	8	sequence	sequence	NOUN
cajgh-41	23	9	much	much	ADV
cajgh-41	23	10	less	less	ADV
cajgh-41	23	11	likely	likely	ADJ
cajgh-41	23	12	to	to	PART
cajgh-41	23	13	be	be	AUX
cajgh-41	23	14	deleterious	deleterious	ADJ
cajgh-41	23	15	,	,	PUNCT
cajgh-41	23	16	particularly	particularly	ADV
cajgh-41	23	17	if	if	SCONJ
cajgh-41	23	18	they	they	PRON
cajgh-41	23	19	were	be	AUX
cajgh-41	23	20	the	the	DET
cajgh-41	23	21	same	same	ADJ
cajgh-41	23	22	sequence	sequence	NOUN
cajgh-41	23	23	variants	variant	NOUN
cajgh-41	23	24	that	that	SCONJ
cajgh-41	23	25	they	they	PRON
cajgh-41	23	26	termed	term	VERB
cajgh-41	23	27	“	"	PUNCT
cajgh-41	23	28	likely	likely	ADJ
cajgh-41	23	29	neutral	neutral	ADJ
cajgh-41	23	30	polymorphisms	polymorphism	NOUN
cajgh-41	23	31	,	,	PUNCT
cajgh-41	23	32	”	"	PUNCT
cajgh-41	23	33	(	(	PUNCT
cajgh-41	23	34	those	those	PRON
cajgh-41	23	35	that	that	PRON
cajgh-41	23	36	were	be	AUX
cajgh-41	23	37	expressed	express	VERB
cajgh-41	23	38	at	at	ADP
cajgh-41	23	39	a	a	DET
cajgh-41	23	40	high	high	ADJ
cajgh-41	23	41	frequency	frequency	NOUN
cajgh-41	23	42	in	in	ADP
cajgh-41	23	43	both	both	DET
cajgh-41	23	44	cases	case	NOUN
cajgh-41	23	45	and	and	CCONJ
cajgh-41	23	46	controls	control	NOUN
cajgh-41	23	47	)	)	PUNCT
cajgh-41	23	48	.	.	PUNCT
cajgh-41	24	1	models	model	NOUN
cajgh-41	24	2	incorporating	incorporate	VERB
cajgh-41	24	3	variables	variable	NOUN
cajgh-41	24	4	from	from	ADP
cajgh-41	24	5	cancer	cancer	NOUN
cajgh-41	24	6	history	history	NOUN
cajgh-41	24	7	of	of	ADP
cajgh-41	24	8	patients	patient	NOUN
cajgh-41	24	9	as	as	ADV
cajgh-41	24	10	well	well	ADV
cajgh-41	24	11	as	as	ADP
cajgh-41	24	12	multiple	multiple	ADJ
cajgh-41	24	13	other	other	ADJ
cajgh-41	24	14	factors	factor	NOUN
cajgh-41	24	15	into	into	ADP
cajgh-41	24	16	logistic	logistic	ADJ
cajgh-41	24	17	regression	regression	NOUN
cajgh-41	24	18	analyses	analysis	NOUN
cajgh-41	24	19	potentially	potentially	ADV
cajgh-41	24	20	have	have	VERB
cajgh-41	24	21	the	the	DET
cajgh-41	24	22	ability	ability	NOUN
cajgh-41	24	23	to	to	PART
cajgh-41	24	24	segregate	segregate	VERB
cajgh-41	24	25	uncertain	uncertain	ADJ
cajgh-41	24	26	brca1	brca1	NOUN
cajgh-41	24	27	and	and	CCONJ
cajgh-41	24	28	brca2	brca2	NOUN
cajgh-41	24	29	variants	variant	NOUN
cajgh-41	24	30	into	into	ADP
cajgh-41	24	31	deleterious	deleterious	ADJ
cajgh-41	24	32	and	and	CCONJ
cajgh-41	24	33	non	non	ADJ
cajgh-41	24	34	-	-	ADJ
cajgh-41	24	35	deleterious	deleterious	ADJ
cajgh-41	24	36	categories.16	categories.16	PROPN
cajgh-41	24	37	-	-	PUNCT
cajgh-41	24	38	22	22	NUM
cajgh-41	24	39	these	these	DET
cajgh-41	24	40	models	model	NOUN
cajgh-41	24	41	work	work	VERB
cajgh-41	24	42	best	well	ADV
cajgh-41	24	43	when	when	SCONJ
cajgh-41	24	44	there	there	PRON
cajgh-41	24	45	are	be	VERB
cajgh-41	24	46	enough	enough	ADJ
cajgh-41	24	47	occurrences	occurrence	NOUN
cajgh-41	24	48	of	of	ADP
cajgh-41	24	49	a	a	DET
cajgh-41	24	50	single	single	ADJ
cajgh-41	24	51	variant	variant	NOUN
cajgh-41	24	52	amongst	amongst	ADP
cajgh-41	24	53	unrelated	unrelated	ADJ
cajgh-41	24	54	families	family	NOUN
cajgh-41	24	55	to	to	PART
cajgh-41	24	56	help	help	VERB
cajgh-41	24	57	aid	aid	NOUN
cajgh-41	24	58	in	in	ADP
cajgh-41	24	59	its	its	PRON
cajgh-41	24	60	classification	classification	NOUN
cajgh-41	24	61	.	.	PUNCT
cajgh-41	25	1	we	we	PRON
cajgh-41	25	2	are	be	AUX
cajgh-41	25	3	still	still	ADV
cajgh-41	25	4	limited	limit	VERB
cajgh-41	25	5	in	in	ADP
cajgh-41	25	6	finding	find	VERB
cajgh-41	25	7	ways	way	NOUN
cajgh-41	25	8	to	to	PART
cajgh-41	25	9	classify	classify	VERB
cajgh-41	25	10	variants	variant	NOUN
cajgh-41	25	11	that	that	PRON
cajgh-41	25	12	occur	occur	VERB
cajgh-41	25	13	rarely	rarely	ADV
cajgh-41	25	14	in	in	ADP
cajgh-41	25	15	a	a	DET
cajgh-41	25	16	specific	specific	ADJ
cajgh-41	25	17	region.23	region.23	NOUN
cajgh-41	25	18	several	several	ADJ
cajgh-41	25	19	resources	resource	NOUN
cajgh-41	25	20	exist	exist	VERB
cajgh-41	25	21	for	for	ADP
cajgh-41	25	22	obtaining	obtain	VERB
cajgh-41	25	23	information	information	NOUN
cajgh-41	25	24	regarding	regard	VERB
cajgh-41	25	25	previously	previously	ADV
cajgh-41	25	26	identified	identify	VERB
cajgh-41	25	27	vus	vus	NOUN
cajgh-41	25	28	and	and	CCONJ
cajgh-41	25	29	snps	snps	PROPN
cajgh-41	25	30	including	include	VERB
cajgh-41	25	31	:	:	PUNCT
cajgh-41	25	32	the	the	DET
cajgh-41	25	33	snp	snp	ADJ
cajgh-41	25	34	consortium,24	consortium,24	X
cajgh-41	25	35	the	the	DET
cajgh-41	25	36	dbsnp	dbsnp	ADJ
cajgh-41	25	37	database	database	NOUN
cajgh-41	25	38	from	from	ADP
cajgh-41	25	39	the	the	DET
cajgh-41	25	40	national	national	ADJ
cajgh-41	25	41	center	center	NOUN
cajgh-41	25	42	for	for	ADP
cajgh-41	25	43	biotechnology	biotechnology	NOUN
cajgh-41	25	44	information	information	NOUN
cajgh-41	25	45	(	(	PUNCT
cajgh-41	25	46	ncbi	ncbi	NOUN
cajgh-41	25	47	)	)	PUNCT
cajgh-41	25	48	,	,	PUNCT
cajgh-41	25	49	the	the	DET
cajgh-41	25	50	breast	breast	NOUN
cajgh-41	25	51	cancer	cancer	NOUN
cajgh-41	25	52	information	information	NOUN
cajgh-41	25	53	core	core	NOUN
cajgh-41	25	54	(	(	PUNCT
cajgh-41	25	55	bic	bic	PROPN
cajgh-41	25	56	)	)	PUNCT
cajgh-41	25	57	(	(	PUNCT
cajgh-41	25	58	http://research.nhgri.nih.gov/bic/	http://research.nhgri.nih.gov/bic/	PROPN
cajgh-41	25	59	)	)	PUNCT
cajgh-41	25	60	,	,	PUNCT
cajgh-41	25	61	and	and	CCONJ
cajgh-41	25	62	hgvbase	hgvbase	PROPN
cajgh-41	25	63	(	(	PUNCT
cajgh-41	25	64	human	human	ADJ
cajgh-41	25	65	genome	genome	NOUN
cajgh-41	25	66	variation	variation	NOUN
cajgh-41	25	67	database	database	NOUN
cajgh-41	25	68	)	)	PUNCT
cajgh-41	25	69	,	,	PUNCT
cajgh-41	25	70	which	which	PRON
cajgh-41	25	71	is	be	AUX
cajgh-41	25	72	a	a	DET
cajgh-41	25	73	human	human	ADJ
cajgh-41	25	74	gene	gene	NOUN
cajgh-41	25	75	-	-	PUNCT
cajgh-41	25	76	based	base	VERB
cajgh-41	25	77	polymorphism	polymorphism	NOUN
cajgh-41	25	78	database	database	NOUN
cajgh-41	25	79	.	.	PUNCT
cajgh-41	26	1	due	due	ADP
cajgh-41	26	2	to	to	ADP
cajgh-41	26	3	the	the	DET
cajgh-41	26	4	difficulty	difficulty	NOUN
cajgh-41	26	5	in	in	ADP
cajgh-41	26	6	screening	screen	VERB
cajgh-41	26	7	the	the	DET
cajgh-41	26	8	literature	literature	NOUN
cajgh-41	26	9	in	in	ADP
cajgh-41	26	10	order	order	NOUN
cajgh-41	26	11	to	to	PART
cajgh-41	26	12	determine	determine	VERB
cajgh-41	26	13	whether	whether	SCONJ
cajgh-41	26	14	a	a	DET
cajgh-41	26	15	specific	specific	ADJ
cajgh-41	26	16	variant	variant	NOUN
cajgh-41	26	17	of	of	ADP
cajgh-41	26	18	uncertain	uncertain	ADJ
cajgh-41	26	19	significance	significance	NOUN
cajgh-41	26	20	has	have	AUX
cajgh-41	26	21	been	be	AUX
cajgh-41	26	22	classified	classify	VERB
cajgh-41	26	23	,	,	PUNCT
cajgh-41	26	24	reporting	report	VERB
cajgh-41	26	25	variants	variant	NOUN
cajgh-41	26	26	to	to	ADP
cajgh-41	26	27	such	such	ADJ
cajgh-41	26	28	large	large	ADJ
cajgh-41	26	29	comprehensive	comprehensive	ADJ
cajgh-41	26	30	databases	database	NOUN
cajgh-41	26	31	of	of	ADP
cajgh-41	26	32	brca1	brca1	PROPN
cajgh-41	26	33	and	and	CCONJ
cajgh-41	26	34	2	2	NUM
cajgh-41	26	35	genes	gene	NOUN
cajgh-41	26	36	is	be	AUX
cajgh-41	26	37	critically	critically	ADV
cajgh-41	26	38	important	important	ADJ
cajgh-41	26	39	.	.	PUNCT
cajgh-41	27	1	additionally	additionally	ADV
cajgh-41	27	2	,	,	PUNCT
cajgh-41	27	3	there	there	PRON
cajgh-41	27	4	is	be	VERB
cajgh-41	27	5	an	an	DET
cajgh-41	27	6	enigma	enigma	ADJ
cajgh-41	27	7	consortium	consortium	NOUN
cajgh-41	27	8	that	that	PRON
cajgh-41	27	9	has	have	AUX
cajgh-41	27	10	been	be	AUX
cajgh-41	27	11	established	establish	VERB
cajgh-41	27	12	to	to	PART
cajgh-41	27	13	evaluate	evaluate	VERB
cajgh-41	27	14	the	the	DET
cajgh-41	27	15	significance	significance	NOUN
cajgh-41	27	16	of	of	ADP
cajgh-41	27	17	uncertain	uncertain	ADJ
cajgh-41	27	18	variants	variant	NOUN
cajgh-41	27	19	in	in	ADP
cajgh-41	27	20	high	high	ADJ
cajgh-41	27	21	-	-	PUNCT
cajgh-41	27	22	risk	risk	NOUN
cajgh-41	27	23	breast	breast	NOUN
cajgh-41	27	24	cancer	cancer	NOUN
cajgh-41	27	25	genes	gene	NOUN
cajgh-41	27	26	.	.	PUNCT
cajgh-41	28	1	the	the	DET
cajgh-41	28	2	success	success	NOUN
cajgh-41	28	3	of	of	ADP
cajgh-41	28	4	this	this	DET
cajgh-41	28	5	group	group	NOUN
cajgh-41	28	6	can	can	AUX
cajgh-41	28	7	only	only	ADV
cajgh-41	28	8	be	be	AUX
cajgh-41	28	9	achieved	achieve	VERB
cajgh-41	28	10	by	by	ADP
cajgh-41	28	11	collecting	collect	VERB
cajgh-41	28	12	genetic	genetic	ADJ
cajgh-41	28	13	and	and	CCONJ
cajgh-41	28	14	clinical	clinical	ADJ
cajgh-41	28	15	information	information	NOUN
cajgh-41	28	16	,	,	PUNCT
cajgh-41	28	17	functional	functional	ADJ
cajgh-41	28	18	assays	assay	NOUN
cajgh-41	28	19	,	,	PUNCT
cajgh-41	28	20	and	and	CCONJ
cajgh-41	28	21	mrna	mrna	PROPN
cajgh-41	28	22	expression	expression	NOUN
cajgh-41	28	23	and	and	CCONJ
cajgh-41	28	24	splicing	splicing	NOUN
cajgh-41	28	25	assays.23	assays.23	PROPN
cajgh-41	28	26	via	via	ADP
cajgh-41	28	27	computational	computational	ADJ
cajgh-41	28	28	approaches	approach	NOUN
cajgh-41	28	29	,	,	PUNCT
cajgh-41	28	30	functional	functional	ADJ
cajgh-41	28	31	assay	assay	NOUN
cajgh-41	28	32	data	datum	NOUN
cajgh-41	28	33	has	have	AUX
cajgh-41	28	34	been	be	AUX
cajgh-41	28	35	shown	show	VERB
cajgh-41	28	36	to	to	PART
cajgh-41	28	37	correlate	correlate	VERB
cajgh-41	28	38	well	well	ADV
cajgh-41	28	39	with	with	ADP
cajgh-41	28	40	pathogenicity	pathogenicity	NOUN
cajgh-41	28	41	of	of	ADP
cajgh-41	28	42	brca1	brca1	PROPN
cajgh-41	28	43	variants	variant	NOUN
cajgh-41	28	44	of	of	ADP
cajgh-41	28	45	uncertain	uncertain	ADJ
cajgh-41	28	46	significance.25	significance.25	NOUN
cajgh-41	28	47	a	a	DET
cajgh-41	28	48	guide	guide	NOUN
cajgh-41	28	49	for	for	ADP
cajgh-41	28	50	functional	functional	ADJ
cajgh-41	28	51	analysis	analysis	NOUN
cajgh-41	28	52	of	of	ADP
cajgh-41	28	53	brca1	brca1	PROPN
cajgh-41	28	54	variants	variant	NOUN
cajgh-41	28	55	of	of	ADP
cajgh-41	28	56	uncertain	uncertain	ADJ
cajgh-41	28	57	significance	significance	NOUN
cajgh-41	28	58	has	have	AUX
cajgh-41	28	59	recently	recently	ADV
cajgh-41	28	60	been	be	AUX
cajgh-41	28	61	published.26	published.26	VERB
cajgh-41	28	62	additionally	additionally	ADV
cajgh-41	28	63	,	,	PUNCT
cajgh-41	28	64	a	a	DET
cajgh-41	28	65	five	five	NUM
cajgh-41	28	66	-	-	PUNCT
cajgh-41	28	67	tiered	tiere	VERB
cajgh-41	28	68	classification	classification	NOUN
cajgh-41	28	69	scheme	scheme	NOUN
cajgh-41	28	70	for	for	ADP
cajgh-41	28	71	dna	dna	PROPN
cajgh-41	28	72	sequence	sequence	NOUN
cajgh-41	28	73	variants	variant	NOUN
cajgh-41	28	74	and	and	CCONJ
cajgh-41	28	75	correlation	correlation	NOUN
cajgh-41	28	76	of	of	ADP
cajgh-41	28	77	clinical	clinical	ADJ
cajgh-41	28	78	recommendation	recommendation	NOUN
cajgh-41	28	79	with	with	ADP
cajgh-41	28	80	probability	probability	NOUN
cajgh-41	28	81	that	that	SCONJ
cajgh-41	28	82	any	any	DET
cajgh-41	28	83	given	give	VERB
cajgh-41	28	84	alteration	alteration	NOUN
cajgh-41	28	85	is	be	AUX
cajgh-41	28	86	deleterious	deleterious	ADJ
cajgh-41	28	87	has	have	AUX
cajgh-41	28	88	been	be	AUX
cajgh-41	28	89	developed	develop	VERB
cajgh-41	28	90	based	base	VERB
cajgh-41	28	91	on	on	ADP
cajgh-41	28	92	the	the	DET
cajgh-41	28	93	posterior	posterior	ADJ
cajgh-41	28	94	probability	probability	NOUN
cajgh-41	28	95	model	model	NOUN
cajgh-41	28	96	,	,	PUNCT
cajgh-41	28	97	with	with	ADP
cajgh-41	28	98	class	class	NOUN
cajgh-41	28	99	1	1	NUM
cajgh-41	28	100	and	and	CCONJ
cajgh-41	28	101	2	2	NUM
cajgh-41	28	102	being	be	AUX
cajgh-41	28	103	not	not	PART
cajgh-41	28	104	likely	likely	ADV
cajgh-41	28	105	pathogenic	pathogenic	ADJ
cajgh-41	28	106	,	,	PUNCT
cajgh-41	28	107	class	class	NOUN
cajgh-41	28	108	3	3	NUM
cajgh-41	28	109	remaining	remain	VERB
cajgh-41	28	110	a	a	DET
cajgh-41	28	111	true	true	ADJ
cajgh-41	28	112	vus	vus	NOUN
cajgh-41	28	113	,	,	PUNCT
cajgh-41	28	114	and	and	CCONJ
cajgh-41	28	115	class	class	NOUN
cajgh-41	28	116	4	4	NUM
cajgh-41	28	117	and	and	CCONJ
cajgh-41	28	118	5	5	NUM
cajgh-41	28	119	considered	consider	VERB
cajgh-41	28	120	pathogenic	pathogenic	ADJ
cajgh-41	28	121	/	/	SYM
cajgh-41	28	122	deleterious	deleterious	ADJ
cajgh-41	28	123	for	for	ADP
cajgh-41	28	124	clinical	clinical	ADJ
cajgh-41	28	125	purposes.27,28	purposes.27,28	NOUN
cajgh-41	28	126	as	as	ADP
cajgh-41	28	127	an	an	DET
cajgh-41	28	128	example	example	NOUN
cajgh-41	28	129	,	,	PUNCT
cajgh-41	28	130	the	the	DET
cajgh-41	28	131	authors	author	NOUN
cajgh-41	28	132	of	of	ADP
cajgh-41	28	133	the	the	DET
cajgh-41	28	134	current	current	ADJ
cajgh-41	28	135	publication	publication	NOUN
cajgh-41	28	136	found	find	VERB
cajgh-41	28	137	a	a	DET
cajgh-41	28	138	brca1	brca1	NOUN
cajgh-41	28	139	amino	amino	NOUN
cajgh-41	28	140	acid	acid	NOUN
cajgh-41	28	141	variant	variant	NOUN
cajgh-41	28	142	of	of	ADP
cajgh-41	28	143	pro871leu	pro871leu	NOUN
cajgh-41	28	144	,	,	PUNCT
cajgh-41	28	145	which	which	PRON
cajgh-41	28	146	is	be	AUX
cajgh-41	28	147	listed	list	VERB
cajgh-41	28	148	as	as	ADP
cajgh-41	28	149	class	class	NOUN
cajgh-41	28	150	1	1	NUM
cajgh-41	28	151	,	,	PUNCT
cajgh-41	28	152	likely	likely	ADJ
cajgh-41	28	153	not	not	PART
cajgh-41	28	154	pathogenic,28	pathogenic,28	NOUN
cajgh-41	28	155	which	which	PRON
cajgh-41	28	156	is	be	AUX
cajgh-41	28	157	consistent	consistent	ADJ
cajgh-41	28	158	with	with	ADP
cajgh-41	28	159	the	the	DET
cajgh-41	28	160	fact	fact	NOUN
cajgh-41	28	161	that	that	SCONJ
cajgh-41	28	162	it	it	PRON
cajgh-41	28	163	was	be	AUX
cajgh-41	28	164	found	find	VERB
cajgh-41	28	165	in	in	ADP
cajgh-41	28	166	about	about	ADV
cajgh-41	28	167	half	half	NOUN
cajgh-41	28	168	of	of	ADP
cajgh-41	28	169	their	their	PRON
cajgh-41	28	170	total	total	ADJ
cajgh-41	28	171	population	population	NOUN
cajgh-41	28	172	,	,	PUNCT
cajgh-41	28	173	both	both	CCONJ
cajgh-41	28	174	in	in	ADP
cajgh-41	28	175	cases	case	NOUN
cajgh-41	28	176	and	and	CCONJ
cajgh-41	28	177	controls	control	NOUN
cajgh-41	28	178	.	.	PUNCT
cajgh-41	29	1	in	in	ADP
cajgh-41	29	2	conclusion	conclusion	NOUN
cajgh-41	29	3	,	,	PUNCT
cajgh-41	29	4	despite	despite	SCONJ
cajgh-41	29	5	major	major	ADJ
cajgh-41	29	6	advances	advance	NOUN
cajgh-41	29	7	in	in	ADP
cajgh-41	29	8	our	our	PRON
cajgh-41	29	9	brca	brca	PROPN
cajgh-41	29	10	testing	testing	NOUN
cajgh-41	29	11	,	,	PUNCT
cajgh-41	29	12	in	in	ADP
cajgh-41	29	13	many	many	ADJ
cajgh-41	29	14	instances	instance	NOUN
cajgh-41	29	15	we	we	PRON
cajgh-41	29	16	are	be	AUX
cajgh-41	29	17	still	still	ADV
cajgh-41	29	18	in	in	ADP
cajgh-41	29	19	a	a	DET
cajgh-41	29	20	very	very	ADV
cajgh-41	29	21	elementary	elementary	ADJ
cajgh-41	29	22	stage	stage	NOUN
cajgh-41	29	23	in	in	ADP
cajgh-41	29	24	applying	apply	VERB
cajgh-41	29	25	such	such	ADJ
cajgh-41	29	26	information	information	NOUN
cajgh-41	29	27	clinically	clinically	ADV
cajgh-41	29	28	toward	toward	ADP
cajgh-41	29	29	the	the	DET
cajgh-41	29	30	care	care	NOUN
cajgh-41	29	31	of	of	ADP
cajgh-41	29	32	patients	patient	NOUN
cajgh-41	29	33	.	.	PUNCT
cajgh-41	30	1	it	it	PRON
cajgh-41	30	2	is	be	AUX
cajgh-41	30	3	only	only	ADV
cajgh-41	30	4	through	through	ADP
cajgh-41	30	5	collaboration	collaboration	NOUN
cajgh-41	30	6	that	that	SCONJ
cajgh-41	30	7	the	the	DET
cajgh-41	30	8	rapidly	rapidly	ADV
cajgh-41	30	9	developing	develop	VERB
cajgh-41	30	10	field	field	NOUN
cajgh-41	30	11	of	of	ADP
cajgh-41	30	12	molecular	molecular	ADJ
cajgh-41	30	13	genetics	genetic	NOUN
cajgh-41	30	14	will	will	AUX
cajgh-41	30	15	lead	lead	VERB
cajgh-41	30	16	to	to	ADP
cajgh-41	30	17	advances	advance	NOUN
cajgh-41	30	18	in	in	ADP
cajgh-41	30	19	patient	patient	ADJ
cajgh-41	30	20	care	care	NOUN
cajgh-41	30	21	.	.	PUNCT
cajgh-41	31	1	references	reference	NOUN
cajgh-41	31	2	1	1	NUM
cajgh-41	31	3	.	.	PUNCT
cajgh-41	32	1	lynch	lynch	PROPN
cajgh-41	32	2	ht	ht	PROPN
cajgh-41	32	3	,	,	PUNCT
cajgh-41	32	4	et	et	PROPN
cajgh-41	32	5	al	al	PROPN
cajgh-41	32	6	.	.	PUNCT
cajgh-41	33	1	clinical	clinical	ADJ
cajgh-41	33	2	/	/	SYM
cajgh-41	33	3	genetic	genetic	ADJ
cajgh-41	33	4	features	feature	NOUN
cajgh-41	33	5	in	in	ADP
cajgh-41	33	6	hereditary	hereditary	ADJ
cajgh-41	33	7	breast	breast	NOUN
cajgh-41	33	8	cancer	cancer	NOUN
cajgh-41	33	9	.	.	PUNCT
cajgh-41	34	1	breast	breast	NOUN
cajgh-41	34	2	cancer	cancer	NOUN
cajgh-41	34	3	res	re	NOUN
cajgh-41	34	4	treat	treat	NOUN
cajgh-41	34	5	.	.	PUNCT
cajgh-41	35	1	1990	1990	NUM
cajgh-41	35	2	;	;	PUNCT
cajgh-41	36	1	15(2):63	15(2):63	NOUN
cajgh-41	36	2	-	-	SYM
cajgh-41	36	3	71	71	NUM
cajgh-41	36	4	.	.	NOUN
cajgh-41	37	1	2	2	X
cajgh-41	37	2	.	.	X
cajgh-41	37	3	pharoah	pharoah	PROPN
cajgh-41	37	4	pd	pd	PROPN
cajgh-41	37	5	,	,	PUNCT
cajgh-41	37	6	et	et	PROPN
cajgh-41	37	7	al	al	PROPN
cajgh-41	37	8	.	.	PUNCT
cajgh-41	38	1	family	family	NOUN
cajgh-41	38	2	history	history	NOUN
cajgh-41	38	3	and	and	CCONJ
cajgh-41	38	4	the	the	DET
cajgh-41	38	5	risk	risk	NOUN
cajgh-41	38	6	of	of	ADP
cajgh-41	38	7	breast	breast	NOUN
cajgh-41	38	8	cancer	cancer	NOUN
cajgh-41	38	9	:	:	PUNCT
cajgh-41	38	10	a	a	DET
cajgh-41	38	11	systematic	systematic	ADJ
cajgh-41	38	12	review	review	NOUN
cajgh-41	38	13	and	and	CCONJ
cajgh-41	38	14	meta	meta	ADJ
cajgh-41	38	15	-	-	PUNCT
cajgh-41	38	16	analysis	analysis	NOUN
cajgh-41	38	17	.	.	PUNCT
cajgh-41	39	1	int	int	NOUN
cajgh-41	39	2	j	j	PROPN
cajgh-41	39	3	cancer	cancer	NOUN
cajgh-41	39	4	.	.	PUNCT
cajgh-41	40	1	1997	1997	NUM
cajgh-41	40	2	;	;	PUNCT
cajgh-41	40	3	71(5):800	71(5):800	NUM
cajgh-41	40	4	-	-	SYM
cajgh-41	40	5	9	9	NUM
cajgh-41	40	6	.	.	NOUN
cajgh-41	40	7	3	3	NUM
cajgh-41	40	8	.	.	X
cajgh-41	40	9	genetic	genetic	ADJ
cajgh-41	40	10	/	/	SYM
cajgh-41	40	11	familial	familial	ADJ
cajgh-41	40	12	high	high	ADJ
cajgh-41	40	13	-	-	PUNCT
cajgh-41	40	14	risk	risk	NOUN
cajgh-41	40	15	assessment	assessment	NOUN
cajgh-41	40	16	:	:	PUNCT
cajgh-41	40	17	breast	breast	NOUN
cajgh-41	40	18	and	and	CCONJ
cajgh-41	40	19	ovarian	ovarian	ADJ
cajgh-41	40	20	.	.	PUNCT
cajgh-41	41	1	nccn	nccn	PROPN
cajgh-41	41	2	guidelines	guidelines	PROPN
cajgh-41	41	3	version	version	PROPN
cajgh-41	41	4	1.2012	1.2012	NUM
cajgh-41	41	5	.	.	PUNCT
cajgh-41	41	6	2012	2012	NUM
cajgh-41	41	7	.	.	PUNCT
cajgh-41	42	1	4	4	X
cajgh-41	42	2	.	.	X
cajgh-41	42	3	foulkes	foulkes	PROPN
cajgh-41	42	4	wd	wd	PROPN
cajgh-41	42	5	.	.	PROPN
cajgh-41	42	6	inherited	inherit	VERB
cajgh-41	42	7	susceptibility	susceptibility	NOUN
cajgh-41	42	8	to	to	ADP
cajgh-41	42	9	common	common	ADJ
cajgh-41	42	10	cancers	cancer	NOUN
cajgh-41	42	11	.	.	PUNCT
cajgh-41	43	1	n	n	PRON
cajgh-41	43	2	engl	engl	PROPN
cajgh-41	43	3	j	j	PROPN
cajgh-41	43	4	med	med	PROPN
cajgh-41	43	5	.	.	PROPN
cajgh-41	43	6	2008	2008	NUM
cajgh-41	43	7	;	;	PUNCT
cajgh-41	44	1	359(20):2143	359(20):2143	PROPN
cajgh-41	44	2	-	-	SYM
cajgh-41	44	3	53	53	NUM
cajgh-41	44	4	.	.	PUNCT
cajgh-41	44	5	5	5	NUM
cajgh-41	44	6	.	.	X
cajgh-41	44	7	pharoah	pharoah	PROPN
cajgh-41	44	8	pd	pd	PROPN
cajgh-41	44	9	,	,	PUNCT
cajgh-41	44	10	et	et	PROPN
cajgh-41	44	11	al	al	PROPN
cajgh-41	44	12	.	.	PROPN
cajgh-41	44	13	polygenic	polygenic	ADJ
cajgh-41	44	14	susceptibility	susceptibility	NOUN
cajgh-41	44	15	to	to	ADP
cajgh-41	44	16	breast	breast	NOUN
cajgh-41	44	17	cancer	cancer	NOUN
cajgh-41	44	18	and	and	CCONJ
cajgh-41	44	19	implications	implication	NOUN
cajgh-41	44	20	for	for	ADP
cajgh-41	44	21	prevention	prevention	NOUN
cajgh-41	44	22	.	.	PUNCT
cajgh-41	45	1	nat	nat	PROPN
cajgh-41	45	2	genet	genet	PROPN
cajgh-41	45	3	.	.	PUNCT
cajgh-41	46	1	2002	2002	NUM
cajgh-41	46	2	;	;	PUNCT
cajgh-41	47	1	31(1):33	31(1):33	NUM
cajgh-41	47	2	-	-	SYM
cajgh-41	47	3	6	6	NUM
cajgh-41	47	4	.	.	NOUN
cajgh-41	47	5	6	6	NUM
cajgh-41	47	6	.	.	X
cajgh-41	48	1	miki	miki	PROPN
cajgh-41	48	2	y	y	PROPN
cajgh-41	48	3	,	,	PUNCT
cajgh-41	48	4	et	et	PROPN
cajgh-41	48	5	al	al	PROPN
cajgh-41	48	6	.	.	PUNCT
cajgh-41	49	1	a	a	DET
cajgh-41	49	2	strong	strong	ADJ
cajgh-41	49	3	candidate	candidate	NOUN
cajgh-41	49	4	for	for	ADP
cajgh-41	49	5	the	the	DET
cajgh-41	49	6	breast	breast	NOUN
cajgh-41	49	7	and	and	CCONJ
cajgh-41	49	8	ovarian	ovarian	ADJ
cajgh-41	49	9	cancer	cancer	NOUN
cajgh-41	49	10	susceptibility	susceptibility	NOUN
cajgh-41	49	11	gene	gene	PROPN
cajgh-41	49	12	brca1	brca1	PROPN
cajgh-41	49	13	.	.	PUNCT
cajgh-41	50	1	science	science	PROPN
cajgh-41	50	2	.	.	PUNCT
cajgh-41	50	3	1994	1994	NUM
cajgh-41	50	4	;	;	PUNCT
cajgh-41	50	5	266(5182):66	266(5182):66	NUM
cajgh-41	50	6	-	-	SYM
cajgh-41	50	7	71	71	NUM
cajgh-41	50	8	.	.	PUNCT
cajgh-41	51	1	7	7	X
cajgh-41	51	2	.	.	X
cajgh-41	51	3	wooster	wooster	PROPN
cajgh-41	51	4	r	r	PROPN
cajgh-41	51	5	,	,	PUNCT
cajgh-41	51	6	et	et	PROPN
cajgh-41	51	7	al	al	PROPN
cajgh-41	51	8	.	.	PUNCT
cajgh-41	52	1	localization	localization	NOUN
cajgh-41	52	2	of	of	ADP
cajgh-41	52	3	a	a	DET
cajgh-41	52	4	breast	breast	NOUN
cajgh-41	52	5	cancer	cancer	NOUN
cajgh-41	52	6	susceptibility	susceptibility	NOUN
cajgh-41	52	7	gene	gene	NOUN
cajgh-41	52	8	,	,	PUNCT
cajgh-41	52	9	brca2	brca2	PROPN
cajgh-41	52	10	,	,	PUNCT
cajgh-41	52	11	to	to	PART
cajgh-41	52	12	chromosome	chromosome	VERB
cajgh-41	52	13	13q12	13q12	NUM
cajgh-41	52	14	-	-	SYM
cajgh-41	52	15	13	13	NUM
cajgh-41	52	16	.	.	PUNCT
cajgh-41	53	1	science	science	NOUN
cajgh-41	53	2	.	.	PUNCT
cajgh-41	53	3	1994	1994	NUM
cajgh-41	53	4	;	;	PUNCT
cajgh-41	53	5	265(5181):2088	265(5181):2088	NUM
cajgh-41	53	6	-	-	SYM
cajgh-41	53	7	90	90	NUM
cajgh-41	53	8	.	.	NOUN
cajgh-41	53	9	8	8	NUM
cajgh-41	53	10	.	.	X
cajgh-41	54	1	woodward	woodward	PROPN
cajgh-41	54	2	am	am	PROPN
cajgh-41	54	3	,	,	PUNCT
cajgh-41	54	4	et	et	PROPN
cajgh-41	54	5	al	al	PROPN
cajgh-41	54	6	.	.	PUNCT
cajgh-41	55	1	large	large	ADJ
cajgh-41	55	2	genomic	genomic	ADJ
cajgh-41	55	3	rearrangements	rearrangement	NOUN
cajgh-41	55	4	of	of	ADP
cajgh-41	55	5	both	both	DET
cajgh-41	55	6	brca2	brca2	PROPN
cajgh-41	55	7	and	and	CCONJ
cajgh-41	55	8	brca1	brca1	PROPN
cajgh-41	55	9	are	be	AUX
cajgh-41	55	10	a	a	DET
cajgh-41	55	11	feature	feature	NOUN
cajgh-41	55	12	of	of	ADP
cajgh-41	55	13	the	the	DET
cajgh-41	55	14	inherited	inherit	VERB
cajgh-41	55	15	breast	breast	NOUN
cajgh-41	55	16	/	/	SYM
cajgh-41	55	17	ovarian	ovarian	ADJ
cajgh-41	55	18	cancer	cancer	NOUN
cajgh-41	55	19	phenotype	phenotype	NOUN
cajgh-41	55	20	in	in	ADP
cajgh-41	55	21	selected	select	VERB
cajgh-41	55	22	families	family	NOUN
cajgh-41	55	23	.	.	PUNCT
cajgh-41	56	1	j	j	PROPN
cajgh-41	56	2	med	med	PROPN
cajgh-41	56	3	genet	genet	PROPN
cajgh-41	56	4	.	.	PUNCT
cajgh-41	57	1	2005	2005	NUM
cajgh-41	57	2	;	;	PUNCT
cajgh-41	57	3	42(5):e31	42(5):e31	NUM
cajgh-41	57	4	.	.	PUNCT
cajgh-41	58	1	9	9	X
cajgh-41	58	2	.	.	X
cajgh-41	58	3	shannon	shannon	PROPN
cajgh-41	58	4	km	km	PROPN
cajgh-41	58	5	,	,	PUNCT
cajgh-41	58	6	chittenden	chittenden	PROPN
cajgh-41	58	7	a.	a.	PROPN
cajgh-41	58	8	genetic	genetic	PROPN
cajgh-41	58	9	testing	testing	NOUN
cajgh-41	58	10	by	by	ADP
cajgh-41	58	11	cancer	cancer	NOUN
cajgh-41	58	12	site	site	NOUN
cajgh-41	58	13	:	:	PUNCT
cajgh-41	58	14	breast	breast	NOUN
cajgh-41	58	15	.	.	PUNCT
cajgh-41	59	1	cancer	cancer	NOUN
cajgh-41	59	2	j.	j.	PROPN
cajgh-41	59	3	18(4):310	18(4):310	PROPN
cajgh-41	59	4	-	-	SYM
cajgh-41	59	5	9	9	NUM
cajgh-41	59	6	.	.	NOUN
cajgh-41	59	7	10	10	NUM
cajgh-41	59	8	.	.	PUNCT
cajgh-41	59	9	levy	levy	NOUN
cajgh-41	59	10	-	-	PUNCT
cajgh-41	59	11	lahad	lahad	NOUN
cajgh-41	59	12	e	e	NOUN
cajgh-41	59	13	,	,	PUNCT
cajgh-41	59	14	et	et	PROPN
cajgh-41	59	15	al	al	PROPN
cajgh-41	59	16	.	.	PROPN
cajgh-41	59	17	founder	founder	PROPN
cajgh-41	59	18	brca1	brca1	PROPN
cajgh-41	59	19	and	and	CCONJ
cajgh-41	59	20	brca2	brca2	NOUN
cajgh-41	59	21	mutations	mutation	NOUN
cajgh-41	59	22	in	in	ADP
cajgh-41	59	23	ashkenazi	ashkenazi	ADJ
cajgh-41	59	24	jews	jews	PROPN
cajgh-41	59	25	in	in	ADP
cajgh-41	59	26	israel	israel	PROPN
cajgh-41	59	27	:	:	PUNCT
cajgh-41	59	28	frequency	frequency	NOUN
cajgh-41	59	29	and	and	CCONJ
cajgh-41	59	30	differential	differential	ADJ
cajgh-41	59	31	penetrance	penetrance	NOUN
cajgh-41	59	32	in	in	ADP
cajgh-41	59	33	ovarian	ovarian	ADJ
cajgh-41	59	34	cancer	cancer	NOUN
cajgh-41	59	35	and	and	CCONJ
cajgh-41	59	36	in	in	ADP
cajgh-41	59	37	breast	breast	NOUN
cajgh-41	59	38	-	-	PUNCT
cajgh-41	59	39	ovarian	ovarian	ADJ
cajgh-41	59	40	cancer	cancer	NOUN
cajgh-41	59	41	families	family	NOUN
cajgh-41	59	42	.	.	PUNCT
cajgh-41	60	1	am	be	AUX
cajgh-41	60	2	j	j	PROPN
cajgh-41	60	3	hum	hum	PROPN
cajgh-41	60	4	genet	genet	PROPN
cajgh-41	60	5	.	.	PUNCT
cajgh-41	61	1	1997	1997	NUM
cajgh-41	61	2	;	;	PUNCT
cajgh-41	61	3	60(5):1059	60(5):1059	NUM
cajgh-41	61	4	-	-	SYM
cajgh-41	61	5	67	67	NUM
cajgh-41	61	6	.	.	PUNCT
cajgh-41	61	7	11	11	NUM
cajgh-41	61	8	.	.	PUNCT
cajgh-41	62	1	king	king	PROPN
cajgh-41	62	2	mc	mc	PROPN
cajgh-41	62	3	,	,	PUNCT
cajgh-41	62	4	marks	mark	VERB
cajgh-41	62	5	jh	jh	PROPN
cajgh-41	62	6	,	,	PUNCT
cajgh-41	62	7	mandell	mandell	PROPN
cajgh-41	62	8	jb	jb	PROPN
cajgh-41	62	9	.	.	PUNCT
cajgh-41	63	1	breast	breast	NOUN
cajgh-41	63	2	and	and	CCONJ
cajgh-41	63	3	ovarian	ovarian	ADJ
cajgh-41	63	4	cancer	cancer	NOUN
cajgh-41	63	5	risks	risk	NOUN
cajgh-41	63	6	due	due	ADJ
cajgh-41	63	7	to	to	ADP
cajgh-41	63	8	inherited	inherit	VERB
cajgh-41	63	9	mutations	mutation	NOUN
cajgh-41	63	10	in	in	ADP
cajgh-41	63	11	brca1	brca1	PROPN
cajgh-41	63	12	and	and	CCONJ
cajgh-41	63	13	brca2	brca2	PROPN
cajgh-41	63	14	.	.	PUNCT
cajgh-41	64	1	science	science	NOUN
cajgh-41	64	2	.	.	PUNCT
cajgh-41	65	1	2003	2003	NUM
cajgh-41	65	2	;	;	PUNCT
cajgh-41	65	3	302(5645):643	302(5645):643	NUM
cajgh-41	65	4	-	-	SYM
cajgh-41	65	5	6	6	NUM
cajgh-41	65	6	.	.	NOUN
cajgh-41	65	7	12	12	NUM
cajgh-41	65	8	.	.	PUNCT
cajgh-41	66	1	brookes	brookes	PROPN
cajgh-41	66	2	aj	aj	PROPN
cajgh-41	66	3	.	.	PUNCT
cajgh-41	67	1	the	the	DET
cajgh-41	67	2	essence	essence	NOUN
cajgh-41	67	3	of	of	ADP
cajgh-41	67	4	snps	snps	PROPN
cajgh-41	67	5	.	.	PUNCT
cajgh-41	68	1	gene	gene	NOUN
cajgh-41	68	2	.	.	PUNCT
cajgh-41	69	1	1999	1999	NUM
cajgh-41	69	2	;	;	PUNCT
cajgh-41	69	3	234(2):177	234(2):177	NUM
cajgh-41	69	4	-	-	SYM
cajgh-41	69	5	86	86	NUM
cajgh-41	69	6	.	.	PUNCT
cajgh-41	70	1	13	13	NUM
cajgh-41	70	2	.	.	PUNCT
cajgh-41	71	1	collins	collins	PROPN
cajgh-41	71	2	kj	kj	PROPN
cajgh-41	71	3	.	.	PUNCT
cajgh-41	71	4	physiological	physiological	ADJ
cajgh-41	71	5	variation	variation	NOUN
cajgh-41	71	6	and	and	CCONJ
cajgh-41	71	7	adaptability	adaptability	NOUN
cajgh-41	71	8	in	in	ADP
cajgh-41	71	9	human	human	ADJ
cajgh-41	71	10	populations	population	NOUN
cajgh-41	71	11	.	.	PUNCT
cajgh-41	72	1	ann	ann	PROPN
cajgh-41	72	2	hum	hum	PROPN
cajgh-41	72	3	biol	biol	PROPN
cajgh-41	72	4	.	.	PUNCT
cajgh-41	73	1	1999	1999	NUM
cajgh-41	73	2	;	;	PUNCT
cajgh-41	73	3	26(1):19	26(1):19	NUM
cajgh-41	73	4	-	-	SYM
cajgh-41	73	5	38	38	NUM
cajgh-41	73	6	.	.	PUNCT
cajgh-41	74	1	14	14	NUM
cajgh-41	74	2	.	.	PUNCT
cajgh-41	75	1	bentley	bentley	PROPN
cajgh-41	75	2	dr	dr	PROPN
cajgh-41	75	3	.	.	PROPN
cajgh-41	76	1	the	the	DET
cajgh-41	76	2	human	human	ADJ
cajgh-41	76	3	genome	genome	NOUN
cajgh-41	76	4	project	project	NOUN
cajgh-41	76	5	--	--	PUNCT
cajgh-41	76	6	an	an	DET
cajgh-41	76	7	overview	overview	NOUN
cajgh-41	76	8	.	.	PUNCT
cajgh-41	77	1	med	med	ADJ
cajgh-41	77	2	res	re	NOUN
cajgh-41	77	3	rev	rev	PROPN
cajgh-41	77	4	.	.	PROPN
cajgh-41	77	5	2000	2000	NUM
cajgh-41	77	6	;	;	PUNCT
cajgh-41	78	1	20(3):189	20(3):189	PROPN
cajgh-41	78	2	-	-	SYM
cajgh-41	78	3	96	96	NUM
cajgh-41	78	4	.	.	NOUN
cajgh-41	78	5	15	15	NUM
cajgh-41	78	6	.	.	PUNCT
cajgh-41	79	1	lindor	lindor	PROPN
cajgh-41	79	2	nm	nm	PROPN
cajgh-41	79	3	,	,	PUNCT
cajgh-41	79	4	et	et	PROPN
cajgh-41	79	5	al	al	PROPN
cajgh-41	79	6	.	.	PUNCT
cajgh-41	80	1	a	a	DET
cajgh-41	80	2	review	review	NOUN
cajgh-41	80	3	of	of	ADP
cajgh-41	80	4	a	a	DET
cajgh-41	80	5	multifactorial	multifactorial	ADJ
cajgh-41	80	6	probability	probability	NOUN
cajgh-41	80	7	-	-	PUNCT
cajgh-41	80	8	based	base	VERB
cajgh-41	80	9	model	model	NOUN
cajgh-41	80	10	for	for	ADP
cajgh-41	80	11	classification	classification	NOUN
cajgh-41	80	12	of	of	ADP
cajgh-41	80	13	brca1	brca1	PROPN
cajgh-41	80	14	and	and	CCONJ
cajgh-41	80	15	brca2	brca2	PROPN
cajgh-41	80	16	variants	variant	NOUN
cajgh-41	80	17	of	of	ADP
cajgh-41	80	18	uncertain	uncertain	ADJ
cajgh-41	80	19	significance	significance	NOUN
cajgh-41	80	20	(	(	PUNCT
cajgh-41	80	21	vus	vus	NOUN
cajgh-41	80	22	)	)	PUNCT
cajgh-41	80	23	.	.	PUNCT
cajgh-41	81	1	hum	hum	PROPN
cajgh-41	81	2	mutat	mutat	PROPN
cajgh-41	81	3	.	.	PUNCT
cajgh-41	81	4	2012	2012	NUM
cajgh-41	81	5	;	;	PUNCT
cajgh-41	81	6	33(1):8	33(1):8	NUM
cajgh-41	81	7	-	-	SYM
cajgh-41	81	8	21	21	NUM
cajgh-41	81	9	.	.	PUNCT
cajgh-41	81	10	16	16	NUM
cajgh-41	81	11	.	.	PUNCT
cajgh-41	82	1	chenevix	chenevix	NOUN
cajgh-41	82	2	-	-	PUNCT
cajgh-41	82	3	trench	trench	NOUN
cajgh-41	82	4	g	g	NOUN
cajgh-41	82	5	,	,	PUNCT
cajgh-41	82	6	et	et	PROPN
cajgh-41	82	7	al	al	PROPN
cajgh-41	82	8	.	.	PUNCT
cajgh-41	83	1	genetic	genetic	ADJ
cajgh-41	83	2	and	and	CCONJ
cajgh-41	83	3	histopathologic	histopathologic	ADJ
cajgh-41	83	4	evaluation	evaluation	NOUN
cajgh-41	83	5	of	of	ADP
cajgh-41	83	6	brca1	brca1	PROPN
cajgh-41	83	7	and	and	CCONJ
cajgh-41	83	8	brca2	brca2	PROPN
cajgh-41	83	9	dna	dna	PROPN
cajgh-41	83	10	sequence	sequence	NOUN
cajgh-41	83	11	variants	variant	NOUN
cajgh-41	83	12	of	of	ADP
cajgh-41	83	13	unknown	unknown	ADJ
cajgh-41	83	14	clinical	clinical	ADJ
cajgh-41	83	15	significance	significance	NOUN
cajgh-41	83	16	.	.	PUNCT
cajgh-41	84	1	cancer	cancer	NOUN
cajgh-41	84	2	res	re	NOUN
cajgh-41	84	3	.	.	PUNCT
cajgh-41	85	1	2006	2006	NUM
cajgh-41	85	2	;	;	PUNCT
cajgh-41	85	3	66(4):2019	66(4):2019	NUM
cajgh-41	85	4	-	-	SYM
cajgh-41	85	5	27	27	NUM
cajgh-41	85	6	.	.	PUNCT
cajgh-41	86	1	17	17	NUM
cajgh-41	86	2	.	.	PUNCT
cajgh-41	86	3	easton	easton	PROPN
cajgh-41	86	4	df	df	PROPN
cajgh-41	86	5	,	,	PUNCT
cajgh-41	86	6	et	et	PROPN
cajgh-41	86	7	al	al	PROPN
cajgh-41	86	8	.	.	PUNCT
cajgh-41	87	1	a	a	DET
cajgh-41	87	2	systematic	systematic	ADJ
cajgh-41	87	3	genetic	genetic	ADJ
cajgh-41	87	4	assessment	assessment	NOUN
cajgh-41	87	5	of	of	ADP
cajgh-41	87	6	1,433	1,433	NUM
cajgh-41	87	7	sequence	sequence	NOUN
cajgh-41	87	8	variants	variant	NOUN
cajgh-41	87	9	of	of	ADP
cajgh-41	87	10	unknown	unknown	ADJ
cajgh-41	87	11	clinical	clinical	ADJ
cajgh-41	87	12	significance	significance	NOUN
cajgh-41	87	13	in	in	ADP
cajgh-41	87	14	the	the	DET
cajgh-41	87	15	brca1	brca1	NOUN
cajgh-41	87	16	and	and	CCONJ
cajgh-41	87	17	brca2	brca2	PROPN
cajgh-41	87	18	breast	breast	NOUN
cajgh-41	87	19	cancer	cancer	NOUN
cajgh-41	87	20	-	-	PUNCT
cajgh-41	87	21	predisposition	predisposition	NOUN
cajgh-41	87	22	genes	gene	NOUN
cajgh-41	87	23	.	.	PUNCT
cajgh-41	88	1	am	be	AUX
cajgh-41	88	2	j	j	PROPN
cajgh-41	88	3	hum	hum	PROPN
cajgh-41	88	4	genet	genet	PROPN
cajgh-41	88	5	.	.	PUNCT
cajgh-41	89	1	2007	2007	NUM
cajgh-41	89	2	;	;	PUNCT
cajgh-41	89	3	81(5):873	81(5):873	NOUN
cajgh-41	89	4	-	-	PUNCT
cajgh-41	89	5	83	83	NUM
cajgh-41	89	6	.	.	PUNCT
cajgh-41	89	7	18	18	NUM
cajgh-41	89	8	.	.	PUNCT
cajgh-41	89	9	goldgar	goldgar	PROPN
cajgh-41	89	10	de	de	PROPN
cajgh-41	89	11	,	,	PUNCT
cajgh-41	89	12	et	et	PROPN
cajgh-41	89	13	al	al	PROPN
cajgh-41	89	14	.	.	PROPN
cajgh-41	89	15	integrated	integrate	VERB
cajgh-41	89	16	evaluation	evaluation	NOUN
cajgh-41	89	17	of	of	ADP
cajgh-41	89	18	dna	dna	PROPN
cajgh-41	89	19	sequence	sequence	NOUN
cajgh-41	89	20	variants	variant	NOUN
cajgh-41	89	21	of	of	ADP
cajgh-41	89	22	unknown	unknown	ADJ
cajgh-41	89	23	clinical	clinical	ADJ
cajgh-41	89	24	significance	significance	NOUN
cajgh-41	89	25	:	:	PUNCT
cajgh-41	89	26	application	application	NOUN
cajgh-41	89	27	to	to	ADP
cajgh-41	89	28	brca1	brca1	PROPN
cajgh-41	89	29	and	and	CCONJ
cajgh-41	89	30	brca2	brca2	PROPN
cajgh-41	89	31	.	.	PUNCT
cajgh-41	89	32	am	be	AUX
cajgh-41	89	33	j	j	PROPN
cajgh-41	89	34	hum	hum	PROPN
cajgh-41	89	35	genet	genet	PROPN
cajgh-41	89	36	.	.	PUNCT
cajgh-41	90	1	2004	2004	NUM
cajgh-41	90	2	;	;	PUNCT
cajgh-41	90	3	75(4):535	75(4):535	PROPN
cajgh-41	90	4	-	-	SYM
cajgh-41	90	5	44	44	NUM
cajgh-41	90	6	.	.	PUNCT
cajgh-41	90	7	19	19	NUM
cajgh-41	90	8	.	.	PUNCT
cajgh-41	90	9	gomez	gomez	PROPN
cajgh-41	90	10	garcia	garcia	PROPN
cajgh-41	90	11	eb	eb	PROPN
cajgh-41	90	12	,	,	PUNCT
cajgh-41	90	13	et	et	PROPN
cajgh-41	90	14	al	al	PROPN
cajgh-41	90	15	.	.	PUNCT
cajgh-41	91	1	a	a	DET
cajgh-41	91	2	method	method	NOUN
cajgh-41	91	3	to	to	PART
cajgh-41	91	4	assess	assess	VERB
cajgh-41	91	5	the	the	DET
cajgh-41	91	6	clinical	clinical	ADJ
cajgh-41	91	7	significance	significance	NOUN
cajgh-41	91	8	of	of	ADP
cajgh-41	91	9	unclassified	unclassified	ADJ
cajgh-41	91	10	variants	variant	NOUN
cajgh-41	91	11	in	in	ADP
cajgh-41	91	12	the	the	DET
cajgh-41	91	13	brca1	brca1	NOUN
cajgh-41	91	14	and	and	CCONJ
cajgh-41	91	15	brca2	brca2	NOUN
cajgh-41	91	16	genes	gene	NOUN
cajgh-41	91	17	based	base	VERB
cajgh-41	91	18	on	on	ADP
cajgh-41	91	19	cancer	cancer	NOUN
cajgh-41	91	20	family	family	NOUN
cajgh-41	91	21	history	history	NOUN
cajgh-41	91	22	.	.	PUNCT
cajgh-41	92	1	breast	breast	NOUN
cajgh-41	92	2	cancer	cancer	NOUN
cajgh-41	92	3	res	re	NOUN
cajgh-41	92	4	.	.	PUNCT
cajgh-41	92	5	2009	2009	NUM
cajgh-41	92	6	;	;	PUNCT
cajgh-41	92	7	11(1):r8	11(1):r8	NUM
cajgh-41	92	8	.	.	PUNCT
cajgh-41	93	1	20	20	NUM
cajgh-41	93	2	.	.	PUNCT
cajgh-41	94	1	spurdle	spurdle	PROPN
cajgh-41	94	2	ab	ab	PROPN
cajgh-41	94	3	,	,	PUNCT
cajgh-41	94	4	et	et	PROPN
cajgh-41	94	5	al	al	PROPN
cajgh-41	94	6	.	.	PROPN
cajgh-41	95	1	clinical	clinical	ADJ
cajgh-41	95	2	classification	classification	NOUN
cajgh-41	95	3	of	of	ADP
cajgh-41	95	4	brca1	brca1	PROPN
cajgh-41	95	5	and	and	CCONJ
cajgh-41	95	6	brca2	brca2	PROPN
cajgh-41	95	7	dna	dna	PROPN
cajgh-41	95	8	sequence	sequence	NOUN
cajgh-41	95	9	variants	variant	NOUN
cajgh-41	95	10	:	:	PUNCT
cajgh-41	95	11	the	the	DET
cajgh-41	95	12	value	value	NOUN
cajgh-41	95	13	of	of	ADP
cajgh-41	95	14	cytokeratin	cytokeratin	NOUN
cajgh-41	95	15	profiles	profile	NOUN
cajgh-41	95	16	and	and	CCONJ
cajgh-41	95	17	evolutionary	evolutionary	ADJ
cajgh-41	95	18	analysis	analysis	NOUN
cajgh-41	95	19	--	--	PUNCT
cajgh-41	95	20	a	a	DET
cajgh-41	95	21	report	report	NOUN
cajgh-41	95	22	from	from	ADP
cajgh-41	95	23	the	the	DET
cajgh-41	95	24	kconfab	kconfab	PROPN
cajgh-41	95	25	investigators	investigator	NOUN
cajgh-41	95	26	.	.	PUNCT
cajgh-41	96	1	j	j	PROPN
cajgh-41	96	2	clin	clin	PROPN
cajgh-41	96	3	oncol	oncol	PROPN
cajgh-41	96	4	.	.	PUNCT
cajgh-41	97	1	2008	2008	NUM
cajgh-41	97	2	;	;	PUNCT
cajgh-41	97	3	26(10):1657	26(10):1657	NUM
cajgh-41	97	4	-	-	SYM
cajgh-41	97	5	63	63	NUM
cajgh-41	97	6	.	.	PUNCT
cajgh-41	98	1	21	21	NUM
cajgh-41	98	2	.	.	PUNCT
cajgh-41	99	1	whiley	whiley	PROPN
cajgh-41	99	2	pj	pj	PROPN
cajgh-41	99	3	,	,	PUNCT
cajgh-41	99	4	et	et	PROPN
cajgh-41	99	5	al	al	PROPN
cajgh-41	99	6	.	.	PUNCT
cajgh-41	99	7	splicing	splicing	NOUN
cajgh-41	99	8	and	and	CCONJ
cajgh-41	99	9	multifactorial	multifactorial	ADJ
cajgh-41	99	10	analysis	analysis	NOUN
cajgh-41	99	11	of	of	ADP
cajgh-41	99	12	intronic	intronic	ADJ
cajgh-41	99	13	brca1	brca1	PROPN
cajgh-41	99	14	and	and	CCONJ
cajgh-41	99	15	brca2	brca2	NOUN
cajgh-41	99	16	sequence	sequence	NOUN
cajgh-41	99	17	variants	variant	NOUN
cajgh-41	99	18	identifies	identify	VERB
cajgh-41	99	19	clinically	clinically	ADV
cajgh-41	99	20	significant	significant	ADJ
cajgh-41	99	21	splicing	splicing	NOUN
cajgh-41	99	22	aberrations	aberration	NOUN
cajgh-41	99	23	up	up	ADP
cajgh-41	99	24	to	to	PART
cajgh-41	99	25	12	12	NUM
cajgh-41	99	26	nucleotides	nucleotide	NOUN
cajgh-41	99	27	from	from	ADP
cajgh-41	99	28	the	the	DET
cajgh-41	99	29	intron	intron	PROPN
cajgh-41	99	30	/	/	SYM
cajgh-41	99	31	exon	exon	PROPN
cajgh-41	99	32	boundary	boundary	NOUN
cajgh-41	99	33	.	.	PUNCT
cajgh-41	100	1	hum	hum	PROPN
cajgh-41	100	2	mutat	mutat	PROPN
cajgh-41	100	3	.	.	PUNCT
cajgh-41	101	1	32(6):678	32(6):678	NUM
cajgh-41	101	2	-	-	SYM
cajgh-41	101	3	87	87	NUM
cajgh-41	101	4	.	.	PUNCT
cajgh-41	102	1	22	22	NUM
cajgh-41	102	2	.	.	PUNCT
cajgh-41	103	1	tavtigian	tavtigian	PROPN
cajgh-41	103	2	sv	sv	PROPN
cajgh-41	103	3	,	,	PUNCT
cajgh-41	103	4	et	et	PROPN
cajgh-41	103	5	al	al	PROPN
cajgh-41	103	6	.	.	PUNCT
cajgh-41	103	7	classification	classification	NOUN
cajgh-41	103	8	of	of	ADP
cajgh-41	103	9	rare	rare	ADJ
cajgh-41	103	10	missense	missense	NOUN
cajgh-41	103	11	substitutions	substitution	NOUN
cajgh-41	103	12	,	,	PUNCT
cajgh-41	103	13	using	use	VERB
cajgh-41	103	14	risk	risk	NOUN
cajgh-41	103	15	surfaces	surface	NOUN
cajgh-41	103	16	,	,	PUNCT
cajgh-41	103	17	with	with	ADP
cajgh-41	103	18	geneticand	geneticand	NOUN
cajgh-41	103	19	molecular	molecular	ADJ
cajgh-41	103	20	-	-	PUNCT
cajgh-41	103	21	epidemiology	epidemiology	NOUN
cajgh-41	103	22	applications	application	NOUN
cajgh-41	103	23	.	.	PUNCT
cajgh-41	104	1	hum	hum	PROPN
cajgh-41	104	2	mutat	mutat	PROPN
cajgh-41	104	3	.	.	PUNCT
cajgh-41	104	4	2008	2008	NUM
cajgh-41	104	5	;	;	PUNCT
cajgh-41	104	6	29(11):1342	29(11):1342	NUM
cajgh-41	104	7	-	-	SYM
cajgh-41	104	8	54	54	NUM
cajgh-41	104	9	.	.	PUNCT
cajgh-41	104	10	23	23	NUM
cajgh-41	104	11	.	.	PUNCT
cajgh-41	105	1	spurdle	spurdle	PROPN
cajgh-41	105	2	ab	ab	PROPN
cajgh-41	105	3	,	,	PUNCT
cajgh-41	105	4	et	et	PROPN
cajgh-41	105	5	al	al	PROPN
cajgh-41	105	6	.	.	PROPN
cajgh-41	106	1	enigma	enigma	PROPN
cajgh-41	106	2	--	--	PUNCT
cajgh-41	106	3	evidence	evidence	NOUN
cajgh-41	106	4	-	-	PUNCT
cajgh-41	106	5	based	base	VERB
cajgh-41	106	6	network	network	NOUN
cajgh-41	106	7	for	for	ADP
cajgh-41	106	8	the	the	DET
cajgh-41	106	9	interpretation	interpretation	NOUN
cajgh-41	106	10	of	of	ADP
cajgh-41	106	11	germline	germline	NOUN
cajgh-41	106	12	mutant	mutant	ADJ
cajgh-41	106	13	alleles	allele	NOUN
cajgh-41	106	14	:	:	PUNCT
cajgh-41	106	15	an	an	DET
cajgh-41	106	16	international	international	ADJ
cajgh-41	106	17	initiative	initiative	NOUN
cajgh-41	106	18	to	to	PART
cajgh-41	106	19	evaluate	evaluate	VERB
cajgh-41	106	20	risk	risk	NOUN
cajgh-41	106	21	and	and	CCONJ
cajgh-41	106	22	clinical	clinical	ADJ
cajgh-41	106	23	significance	significance	NOUN
cajgh-41	106	24	associated	associate	VERB
cajgh-41	106	25	with	with	ADP
cajgh-41	106	26	sequence	sequence	NOUN
cajgh-41	106	27	variation	variation	NOUN
cajgh-41	106	28	in	in	ADP
cajgh-41	106	29	brca1	brca1	PROPN
cajgh-41	106	30	and	and	CCONJ
cajgh-41	106	31	brca2	brca2	NOUN
cajgh-41	106	32	genes	gene	NOUN
cajgh-41	106	33	.	.	PUNCT
cajgh-41	107	1	hum	hum	PROPN
cajgh-41	107	2	mutat	mutat	PROPN
cajgh-41	107	3	.	.	PUNCT
cajgh-41	108	1	33(1):2	33(1):2	NUM
cajgh-41	108	2	-	-	SYM
cajgh-41	108	3	7	7	NUM
cajgh-41	108	4	.	.	NUM
cajgh-41	108	5	24	24	NUM
cajgh-41	108	6	.	.	PUNCT
cajgh-41	108	7	thorisson	thorisson	PROPN
cajgh-41	108	8	ga	ga	PROPN
cajgh-41	108	9	,	,	PUNCT
cajgh-41	108	10	stein	stein	PROPN
cajgh-41	108	11	ld	ld	PROPN
cajgh-41	108	12	.	.	PUNCT
cajgh-41	109	1	the	the	DET
cajgh-41	109	2	snp	snp	PROPN
cajgh-41	109	3	consortium	consortium	PROPN
cajgh-41	109	4	website	website	NOUN
cajgh-41	109	5	:	:	PUNCT
cajgh-41	109	6	past	past	ADJ
cajgh-41	109	7	,	,	PUNCT
cajgh-41	109	8	present	present	ADJ
cajgh-41	109	9	and	and	CCONJ
cajgh-41	109	10	future	future	ADJ
cajgh-41	109	11	.	.	PUNCT
cajgh-41	110	1	nucleic	nucleic	ADJ
cajgh-41	110	2	acids	acid	NOUN
cajgh-41	110	3	res	re	NOUN
cajgh-41	110	4	.	.	PUNCT
cajgh-41	110	5	2003	2003	NUM
cajgh-41	110	6	;	;	PUNCT
cajgh-41	110	7	31(1):124	31(1):124	NUM
cajgh-41	110	8	-	-	SYM
cajgh-41	110	9	7	7	NUM
cajgh-41	110	10	.	.	NUM
cajgh-41	110	11	25	25	NUM
cajgh-41	110	12	.	.	PUNCT
cajgh-41	111	1	iversen	iversen	PROPN
cajgh-41	111	2	jr	jr	PROPN
cajgh-41	111	3	es	es	PROPN
cajgh-41	111	4	,	,	PUNCT
cajgh-41	111	5	et	et	PROPN
cajgh-41	111	6	al	al	PROPN
cajgh-41	111	7	.	.	PUNCT
cajgh-41	112	1	a	a	DET
cajgh-41	112	2	computational	computational	ADJ
cajgh-41	112	3	method	method	NOUN
cajgh-41	112	4	to	to	PART
cajgh-41	112	5	classify	classify	VERB
cajgh-41	112	6	variants	variant	NOUN
cajgh-41	112	7	of	of	ADP
cajgh-41	112	8	uncertain	uncertain	ADJ
cajgh-41	112	9	significance	significance	NOUN
cajgh-41	112	10	using	use	VERB
cajgh-41	112	11	functional	functional	ADJ
cajgh-41	112	12	assay	assay	NOUN
cajgh-41	112	13	data	datum	NOUN
cajgh-41	112	14	with	with	ADP
cajgh-41	112	15	application	application	NOUN
cajgh-41	112	16	to	to	ADP
cajgh-41	112	17	brca1	brca1	PROPN
cajgh-41	112	18	.	.	PUNCT
cajgh-41	113	1	cancer	cancer	NOUN
cajgh-41	113	2	epidemiol	epidemiol	PROPN
cajgh-41	113	3	biomarkers	biomarker	NOUN
cajgh-41	113	4	prev	prev	NOUN
cajgh-41	113	5	.	.	PUNCT
cajgh-41	114	1	20(6):1078	20(6):1078	NUM
cajgh-41	114	2	-	-	SYM
cajgh-41	114	3	88	88	NUM
cajgh-41	114	4	.	.	PUNCT
cajgh-41	115	1	26	26	NUM
cajgh-41	115	2	.	.	PUNCT
cajgh-41	115	3	millot	millot	PROPN
cajgh-41	115	4	ga	ga	PROPN
cajgh-41	115	5	,	,	PUNCT
cajgh-41	115	6	et	et	PROPN
cajgh-41	115	7	al	al	PROPN
cajgh-41	115	8	.	.	PUNCT
cajgh-41	116	1	a	a	DET
cajgh-41	116	2	guide	guide	NOUN
cajgh-41	116	3	for	for	ADP
cajgh-41	116	4	functional	functional	ADJ
cajgh-41	116	5	analysis	analysis	NOUN
cajgh-41	116	6	of	of	ADP
cajgh-41	116	7	brca1	brca1	PROPN
cajgh-41	116	8	variants	variant	NOUN
cajgh-41	116	9	of	of	ADP
cajgh-41	116	10	uncertain	uncertain	ADJ
cajgh-41	116	11	significance	significance	NOUN
cajgh-41	116	12	.	.	PUNCT
cajgh-41	117	1	hum	hum	PROPN
cajgh-41	117	2	mutat	mutat	PROPN
cajgh-41	117	3	.	.	PUNCT
cajgh-41	118	1	27	27	NUM
cajgh-41	118	2	.	.	PUNCT
cajgh-41	118	3	plon	plon	PROPN
cajgh-41	118	4	se	se	PROPN
cajgh-41	118	5	,	,	PUNCT
cajgh-41	118	6	et	et	PROPN
cajgh-41	118	7	al	al	PROPN
cajgh-41	118	8	.	.	PUNCT
cajgh-41	118	9	sequence	sequence	NOUN
cajgh-41	118	10	variant	variant	NOUN
cajgh-41	118	11	classification	classification	NOUN
cajgh-41	118	12	and	and	CCONJ
cajgh-41	118	13	reporting	reporting	NOUN
cajgh-41	118	14	:	:	PUNCT
cajgh-41	118	15	recommendations	recommendation	NOUN
cajgh-41	118	16	for	for	ADP
cajgh-41	118	17	improving	improve	VERB
cajgh-41	118	18	the	the	DET
cajgh-41	118	19	interpretation	interpretation	NOUN
cajgh-41	118	20	of	of	ADP
cajgh-41	118	21	cancer	cancer	NOUN
cajgh-41	118	22	susceptibility	susceptibility	NOUN
cajgh-41	118	23	genetic	genetic	ADJ
cajgh-41	118	24	test	test	NOUN
cajgh-41	118	25	results	result	NOUN
cajgh-41	118	26	.	.	PUNCT
cajgh-41	119	1	hum	hum	PROPN
cajgh-41	119	2	mutat	mutat	PROPN
cajgh-41	119	3	.	.	PUNCT
cajgh-41	119	4	2008	2008	NUM
cajgh-41	119	5	;	;	PUNCT
cajgh-41	119	6	29(11):1282	29(11):1282	NUM
cajgh-41	119	7	-	-	SYM
cajgh-41	119	8	91	91	NUM
cajgh-41	119	9	.	.	PUNCT
cajgh-41	120	1	28	28	NUM
cajgh-41	120	2	.	.	PUNCT
cajgh-41	121	1	lindor	lindor	PROPN
cajgh-41	121	2	nm	nm	PROPN
cajgh-41	121	3	,	,	PUNCT
cajgh-41	121	4	et	et	PROPN
cajgh-41	121	5	al	al	PROPN
cajgh-41	121	6	.	.	PUNCT
cajgh-41	122	1	a	a	DET
cajgh-41	122	2	review	review	NOUN
cajgh-41	122	3	of	of	ADP
cajgh-41	122	4	a	a	DET
cajgh-41	122	5	multifactorial	multifactorial	ADJ
cajgh-41	122	6	probability	probability	NOUN
cajgh-41	122	7	-	-	PUNCT
cajgh-41	122	8	based	base	VERB
cajgh-41	122	9	model	model	NOUN
cajgh-41	122	10	for	for	ADP
cajgh-41	122	11	classification	classification	NOUN
cajgh-41	122	12	of	of	ADP
cajgh-41	122	13	brca1	brca1	PROPN
cajgh-41	122	14	and	and	CCONJ
cajgh-41	122	15	brca2	brca2	PROPN
cajgh-41	122	16	variants	variant	NOUN
cajgh-41	122	17	of	of	ADP
cajgh-41	122	18	uncertain	uncertain	ADJ
cajgh-41	122	19	significance	significance	NOUN
cajgh-41	122	20	(	(	PUNCT
cajgh-41	122	21	vus	vus	NOUN
cajgh-41	122	22	)	)	PUNCT
cajgh-41	122	23	.	.	PUNCT
cajgh-41	123	1	hum	hum	PROPN
cajgh-41	123	2	mutat	mutat	PROPN
cajgh-41	123	3	.	.	PUNCT
cajgh-41	124	1	33(1):8	33(1):8	NUM
cajgh-41	124	2	-	-	SYM
cajgh-41	124	3	21	21	NUM
cajgh-41	124	4	.	.	PUNCT