Health benefits of new symbiotic “NAR”


 

 

New articles in this journal are licensed under a Creative Commons Attribution 3.0 United States License. 

 

 

This journal is published by theUniversity Library System of the University of Pittsburgh as part  

of its D-Scribe Digital Publishing Program and is cosponsored by the University of Pittsburgh Press. 

 

 

 

 

 

 

 
 

 

 

 

Health benefits of new symbiotic 

“NAR” 

 

Saule Saduakhasova, Almagul 

Kushugulova, Samat 

Kozhakhmetov, Gulnara 

Shakhabayeva, Adil Supiyev, 

Zhanagul Khasenbekova, Indira 

Tynybayeva, Talgat Nurgozhin, 

Zhaxybay Zhumadilov 

 

Center for Life Sciences, Nazarbayev 

University, Astana, Kazakhstan 

 

 

Vol. 2, Suppl. (2013)   |   ISSN 2166-7403 (online)  

DOI 10.5195/cajgh.2013.114  |   http://cajgh.pitt.edu 

http://www.library.pitt.edu/
http://www.pitt.edu/
http://www.library.pitt.edu/articles/digpubtype/index.html
http://www.upress.pitt.edu/upressIndex.aspx
http://creativecommons.org/licenses/by/3.0/us/


 

 

SADUAKHASOVA 

 

 

This work is licensed under a Creative Commons Attribution 3.0 United States License. 

 

This journal is published by theUniversity Library System of the University of Pittsburgh as part  

of its D-Scribe Digital Publishing Program and is cosponsored by the University of Pittsburgh Press. 

 

Central Asian Journal of Global Health 

Volume 2, Suppl. (2013) |  ISSN 2166-7403 (online)  |  DOI 10.5195/cajgh.2013.114  |  http://cajgh.pitt.edu 

 

 

Abstract 

Introduction: The immune-modulatory effects of synbiotics and their ability to reduce free radical levels may be useful for 

functional food that is able to be active throughout whole period of colonization of the gastrointestinal tract. 

 

The aim of the present study was to investigate the immune-modulatory and antioxidant effects of the synbiotic product "NАR," 

a probiotic beverage. 

 

Methods: The presence of IL-2, IL-4, IL-6, IL-8, IL-10, αTNF, γIFN, Ig A, Ig M, and Ig E was studied in vitro using a solid 

immunosorbent analysis. The total antioxidant activities of superoxide dismutase and glutathione reductase were determined by a 

spectrophotometry using the Sigma-Aldrich sets. 

 

Results: Studies of the immune-modulatory properties of the synbiotic product NAR showed 1.7 fold increase of γINF levels 

(p<0.01) in blood after consumption of the synbiotic product “NAR” in comparison to control values, whereas the concentrations 

of IL-4 and Ig E decreased 2.0 times (treatment: 9.3; control: 18.7; p<0.01) and 1.3 times (p<0.1), respectively. The consumption 

of the synbiotic product “NAR” caused an increase in the proportion of γINF/IL 4 (treatment: 15.4; control: 4.4; p<0.01), which 

indicates a reduction in functional activity of Th2-type lymphocytes in comparison with the function of Th1 cells. 

 

Our study showed a high level of the total antioxidant activity of the synbiotic product (67.4 mmol/ml). The antioxidant activity 

of the intact cells of consortium (15.3 mM/ml), which was the basis for the preparation of the symbiotic product, is several times 

lower than the activity observed in the symbiotic samples. 

 

Expression of SOD is one of the mechanisms of antioxidant stress radicals inactivation by bacteria. The analysis identified a 

superoxide dismutase activity of synbiotic product (1.42 U/mg protein). A glutathione reductase activity of the synbiotic product 

was elevated (0.06 U/ml). 

 

Conclusion: The majority of the inflammatory mediators found in the blood after the consumption of symbiotic product NAR 

were inflammatory mediators that activate a cellular component of the resistance. Moreover, the symbiotic product has a high 

antioxidant activity. 

Keywords: synbiotics, immune modulation, antioxidant activity 

 

http://www.library.pitt.edu/
http://www.pitt.edu/
http://www.library.pitt.edu/articles/digpubtype/index.html
http://www.upress.pitt.edu/upressIndex.aspx