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This journal is published by the University Library System of the University of Pittsburgh as part  

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Features of Cytokine Profile in 

Different Age Groups 

 

Alikhan Shortanbayev, Beibitgul 

Bizhigitova, Anel Tarabayeva, 

Aliya Nurmuchanbetova  

 
Department of General Immunology, 
S.D. Asfendiyarov Kazakh National 
Medical University, Almaty, Kazakhstan 

 

 

 

 

 

 

 

 

 

 

Vol. 3, Suppl. (2014)   |   ISSN 2166-7403 (online)    

DOI 10.5195/cajgh.2014.173   |   http://cajgh.pitt.edu 

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SHORTANBAYEV 

 

 

This work is licensed under a Creative Commons Attribution 4.0 United States License. 

 

This journal is published by the University Library System of the University of Pittsburgh as part  

of its D-Scribe Digital Publishing Program and is cosponsored by the University of Pittsburgh Press. 

 

Central Asian Journal of Global Health 

Volume 3, Suppl. (2014)  |  ISSN 2166-7403 (online)  |  DOI 10.5195/cajgh.2014.173  |  http://cajgh.pitt.edu 

  

 

Abstract 

Introduction. The study of the cytokine profile during aging is interesting because age-related changes of the immune status are 

usually correlate with the onset of specific diseases. Characteristics of cytokine activity in the elderly can not only detail the 

pathogenesis of the disease but also help to choose the appropriate therapeutic strategy, which in addition to the therapeutic effect 

could improve the quality of life of the elderly. The purpose of this study was to examine cytokine levels in older adults. 

Material and methods. We examined 268 people aged 45-80 years and older. All surveyed individuals were divided into 8 

different age groups. All participants were tested for concentrations of IL-1β, IL-2, TNF- and IFN-γ. 

Results. The study found that concentrations of TNF- increased with age. For age group 45-49, the concentration of TNF- was 

5.94 pcg/ml. In older age groups, there was a gradual increase in cytokine concentration. In a group of centenarians, concentration 

of TNF-  reached 20.55 pcg/ml, which is 3.4 times higher compared to the middle age group. Similar trends were found in the 

concentration of IL-1. For the age group of 45-49, the concentration of IL-1  was 3.38 pcg/ml, and in the age group of 80 years 

and older, levels of this cytokine increased almost 5 times. It was found that with age-related there is a gradual decrease in the level 

of IL-2, and a gradual increase of IFN-γ. The decrease in IL-2 is due to the typical aging decrease in the amount of T-lymphocytes.  

Conclusion. Thus, our results indicate that there are significant deviations of immune parameters, particularly in cytokine 

concentrations, in older adults compared to middle aged adults.  

Keywords: aging, cytokines, immunity 

 

 

 

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