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This journal is published by theUniversity Library System of the University of Pittsburgh as part  

of its D-Scribe Digital Publishing Program and is cosponsored by the University of Pittsburgh Press. 

 

 

 

 

 

 

 

 

Pregnancy Outcomes Complicated 

by Preterm Premature Rupture of 

Membranes:  
Retrospective Review of Cases in Three 
Institutions in Kazakhstan 

 

Balkenzhe Imankulova, Gulzhanat 

Aimagambetova, Layzzat 

Saiddildina, Talshyn Ukybassova 
National Research Center for Maternal 
and Child Health, Astana, Kazakhstan 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

Vol. 3, Suppl. (2014)   |   ISSN 2166-7403 (online)  

DOI 10.5195/cajgh.2014.222 |   http://cajgh.pitt.edu 

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IMANKULOVA 

 

 

This work is licensed under a Creative Commons Attribution 4.0 United States License. 

 

This journal is published by theUniversity Library System of the University of Pittsburgh as part  

of its D-Scribe Digital Publishing Program and is cosponsored by the University of Pittsburgh Press. 

 

Central Asian Journal of Global Health 

Volume 3, Suppl. (2014) |  ISSN 2166-7403 (online) | DOI 10.5195/cajgh.2014.222|http://cajgh.pitt.edu 

 

 

Abstract 

Introduction. Pre-term premature rupture of membranes (PPROM) is one of the leading causes of perinatal morbidity and 

mortality. This complication is diagnosed in 3% of pregnant women in Kazakhstan, and it is the leading cause of pre-term deliveries. 

The aim of this study was to determine the outcomes of pregnancies complicated by PPROM in gestation periods between 24 to 

32 weeks among three institutions in Kazakhstan. 

Methods. This is descriptive analysis of 154 cases with PPROM observed between 24 to 32 weeks of gestation at Perinatal Centers 

#2 and #3 and the National Research Center for Maternal and Child Health, Astana, Kazakhstan. Cases were selected on the basis 

of retrospective chart review where PPROM diagnosis occurred in 2013. Descriptive statistics were utilized for data analysis. 

Results. The most frequent complications associated with PPROM were threat of miscarriage (13.6% of cases) and chronic 

placental insufficiency (7.8%). The mean time between PPROM and onset of spontaneous labor was 12.1 ± 2.3 days.  Spontaneous 

labor within 3 days after PPROM started in patients with an amniotic fluid index of 3.0 ± 0.2 cm. Complications experienced by 

PPROM women during delivery and early postpartum period included: precipitous labor (6.4%), weakness of labor activity 

(16.2%), atonic hemorrhage (1.2%), and chorioamnionitis (3.2%). 37.6% of newborns in this study were admitted to the Intensive 

Care Unit. Their health complications included pneumonia (7.7%), conjunctivitis (1.3%), omphalitis and infectious-toxic shock 

(3.8%), intraventricular hemorrhage  (7.8%), and respiratory distress (10.3% ). 

Conclusion. Thus, preterm rupture of membranes is associated with preterm delivery and an increase of neonatal morbidity. 

Therefore, it is necessary to find ways to effectively manage PPROM, including developing new techniques to restore the amniotic 

fluid volume in women experiencing PPROM during 24 to 32 weeks of gestation.  

Keywords: perinatal mortality, perinatal morbidity, pre-term membrane rupture, pre-term delivery 

 

 

 

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