id	sid	tid	token	lemma	pos
can-1683	1	1	characterization	characterization	NOUN
can-1683	1	2	and	and	CCONJ
can-1683	1	3	application	application	NOUN
can-1683	1	4	of	of	ADP
can-1683	1	5	nanomaterials	nanomaterial	NOUN
can-1683	1	6	(	(	PUNCT
can-1683	1	7	2022	2022	NUM
can-1683	1	8	)	)	PUNCT
can-1683	1	9	volume	volume	NOUN
can-1683	1	10	5	5	NUM
can-1683	1	11	issue	issue	NOUN
can-1683	1	12	2	2	NUM
can-1683	1	13	doi:10.24294	doi:10.24294	NOUN
can-1683	1	14	/	/	SYM
can-1683	1	15	can.v5i2.1683	can.v5i2.1683	PROPN
can-1683	1	16	9	9	NUM
can-1683	1	17	review	review	NOUN
can-1683	1	18	article	article	NOUN
can-1683	1	19	application	application	NOUN
can-1683	1	20	of	of	ADP
can-1683	1	21	the	the	DET
can-1683	1	22	nano	nano	NOUN
can-1683	1	23	drug	drug	NOUN
can-1683	1	24	delivery	delivery	NOUN
can-1683	1	25	system	system	NOUN
can-1683	1	26	in	in	ADP
can-1683	1	27	the	the	DET
can-1683	1	28	treatment	treatment	NOUN
can-1683	1	29	of	of	ADP
can-1683	1	30	cardiovascular	cardiovascular	ADJ
can-1683	1	31	diseases	disease	NOUN
can-1683	1	32	ramaiyan	ramaiyan	ADJ
can-1683	1	33	velmurugan	velmurugan	PROPN
can-1683	1	34	*	*	PROPN
can-1683	1	35	,	,	PUNCT
can-1683	1	36	shankar	shankar	PROPN
can-1683	1	37	swabanu	swabanu	PROPN
can-1683	1	38	faculty	faculty	NOUN
can-1683	1	39	of	of	ADP
can-1683	1	40	pharmaceutical	pharmaceutical	ADJ
can-1683	1	41	sciences	science	NOUN
can-1683	1	42	,	,	PUNCT
can-1683	1	43	saveetha	saveetha	PROPN
can-1683	1	44	institute	institute	PROPN
can-1683	1	45	of	of	ADP
can-1683	1	46	medical	medical	ADJ
can-1683	1	47	and	and	CCONJ
can-1683	1	48	technical	technical	ADJ
can-1683	1	49	sciences	sciences	PROPN
can-1683	1	50	,	,	PUNCT
can-1683	1	51	chennai	chennai	PROPN
can-1683	1	52	,	,	PUNCT
can-1683	1	53	india	india	PROPN
can-1683	1	54	.	.	PUNCT
can-1683	1	55	email	email	NOUN
can-1683	1	56	:	:	PUNCT
can-1683	1	57	ramaiyan.dr@gmail.com	ramaiyan.dr@gmail.com	PROPN
can-1683	1	58	abstract	abstract	NOUN
can-1683	1	59	in	in	ADP
can-1683	1	60	the	the	DET
can-1683	1	61	last	last	ADJ
can-1683	1	62	several	several	ADJ
can-1683	1	63	decades	decade	NOUN
can-1683	1	64	,	,	PUNCT
can-1683	1	65	cardiovascular	cardiovascular	ADJ
can-1683	1	66	diseases	disease	NOUN
can-1683	1	67	(	(	PUNCT
can-1683	1	68	cvds	cvds	PROPN
can-1683	1	69	)	)	PUNCT
can-1683	1	70	have	have	AUX
can-1683	1	71	emerged	emerge	VERB
can-1683	1	72	as	as	ADP
can-1683	1	73	a	a	DET
can-1683	1	74	major	major	ADJ
can-1683	1	75	hazard	hazard	NOUN
can-1683	1	76	to	to	ADP
can-1683	1	77	human	human	ADJ
can-1683	1	78	life	life	NOUN
can-1683	1	79	and	and	CCONJ
can-1683	1	80	health	health	NOUN
can-1683	1	81	.	.	PUNCT
can-1683	2	1	conventional	conventional	ADJ
can-1683	2	2	formulations	formulation	NOUN
can-1683	2	3	for	for	ADP
can-1683	2	4	the	the	DET
can-1683	2	5	treatment	treatment	NOUN
can-1683	2	6	of	of	ADP
can-1683	2	7	cvd	cvd	PROPN
can-1683	2	8	are	be	AUX
can-1683	2	9	available	available	ADJ
can-1683	2	10	,	,	PUNCT
can-1683	2	11	but	but	CCONJ
can-1683	2	12	they	they	PRON
can-1683	2	13	are	be	AUX
can-1683	2	14	far	far	ADV
can-1683	2	15	from	from	ADP
can-1683	2	16	ideal	ideal	ADJ
can-1683	2	17	because	because	SCONJ
can-1683	2	18	of	of	ADP
can-1683	2	19	poor	poor	ADJ
can-1683	2	20	water	water	NOUN
can-1683	2	21	solubility	solubility	NOUN
can-1683	2	22	,	,	PUNCT
can-1683	2	23	limited	limited	ADJ
can-1683	2	24	biological	biological	ADJ
can-1683	2	25	activity	activity	NOUN
can-1683	2	26	,	,	PUNCT
can-1683	2	27	non	non	ADJ
can-1683	2	28	-	-	ADJ
can-1683	2	29	targeting	targeting	ADJ
can-1683	2	30	,	,	PUNCT
can-1683	2	31	and	and	CCONJ
can-1683	2	32	drug	drug	NOUN
can-1683	2	33	resistance	resistance	NOUN
can-1683	2	34	.	.	PUNCT
can-1683	3	1	with	with	ADP
can-1683	3	2	the	the	DET
can-1683	3	3	advancement	advancement	NOUN
can-1683	3	4	of	of	ADP
can-1683	3	5	nanotechnology	nanotechnology	NOUN
can-1683	3	6	,	,	PUNCT
can-1683	3	7	a	a	DET
can-1683	3	8	novel	novel	ADJ
can-1683	3	9	drug	drug	NOUN
can-1683	3	10	delivery	delivery	NOUN
can-1683	3	11	approach	approach	NOUN
can-1683	3	12	for	for	ADP
can-1683	3	13	the	the	DET
can-1683	3	14	treatment	treatment	NOUN
can-1683	3	15	of	of	ADP
can-1683	3	16	cvds	cvds	PROPN
can-1683	3	17	has	have	AUX
can-1683	3	18	emerged	emerge	VERB
can-1683	3	19	:	:	PUNCT
can-1683	3	20	nano	nano	NOUN
can-1683	3	21	-	-	PUNCT
can-1683	3	22	drug	drug	NOUN
can-1683	3	23	delivery	delivery	NOUN
can-1683	3	24	systems	system	NOUN
can-1683	3	25	(	(	PUNCT
can-1683	3	26	nddss	nddss	NOUN
can-1683	3	27	)	)	PUNCT
can-1683	3	28	.	.	PUNCT
can-1683	4	1	nddss	nddss	PROPN
can-1683	4	2	have	have	AUX
can-1683	4	3	shown	show	VERB
can-1683	4	4	significant	significant	ADJ
can-1683	4	5	advantages	advantage	NOUN
can-1683	4	6	in	in	ADP
can-1683	4	7	tackling	tackle	VERB
can-1683	4	8	the	the	DET
can-1683	4	9	difficulties	difficulty	NOUN
can-1683	4	10	listed	list	VERB
can-1683	4	11	above	above	ADV
can-1683	4	12	.	.	PUNCT
can-1683	5	1	cytotoxicity	cytotoxicity	NOUN
can-1683	5	2	is	be	AUX
can-1683	5	3	a	a	DET
can-1683	5	4	difficulty	difficulty	NOUN
can-1683	5	5	with	with	ADP
can-1683	5	6	the	the	DET
can-1683	5	7	use	use	NOUN
can-1683	5	8	of	of	ADP
can-1683	5	9	non	non	ADJ
can-1683	5	10	-	-	ADJ
can-1683	5	11	destructive	destructive	ADJ
can-1683	5	12	dna	dna	PROPN
can-1683	5	13	sequences	sequence	NOUN
can-1683	5	14	.	.	PUNCT
can-1683	6	1	ndds	ndds	PROPN
can-1683	6	2	categories	category	NOUN
can-1683	6	3	and	and	CCONJ
can-1683	6	4	targeted	target	VERB
can-1683	6	5	tactics	tactic	NOUN
can-1683	6	6	were	be	AUX
can-1683	6	7	outlined	outline	VERB
can-1683	6	8	,	,	PUNCT
can-1683	6	9	as	as	ADV
can-1683	6	10	well	well	ADV
can-1683	6	11	as	as	ADP
can-1683	6	12	current	current	ADJ
can-1683	6	13	research	research	NOUN
can-1683	6	14	advancements	advancement	NOUN
can-1683	6	15	in	in	ADP
can-1683	6	16	the	the	DET
can-1683	6	17	diagnosis	diagnosis	NOUN
can-1683	6	18	and	and	CCONJ
can-1683	6	19	treatment	treatment	NOUN
can-1683	6	20	of	of	ADP
can-1683	6	21	cvds	cvds	PROPN
can-1683	6	22	.	.	PUNCT
can-1683	7	1	it	it	PRON
can-1683	7	2	’s	’	VERB
can-1683	7	3	possible	possible	ADJ
can-1683	7	4	that	that	SCONJ
can-1683	7	5	gene	gene	NOUN
can-1683	7	6	therapy	therapy	NOUN
can-1683	7	7	might	might	AUX
can-1683	7	8	be	be	AUX
can-1683	7	9	included	include	VERB
can-1683	7	10	into	into	ADP
can-1683	7	11	nano	nano	NOUN
can-1683	7	12	-	-	PUNCT
can-1683	7	13	carriers	carrier	NOUN
can-1683	7	14	in	in	ADP
can-1683	7	15	the	the	DET
can-1683	7	16	delivery	delivery	NOUN
can-1683	7	17	of	of	ADP
can-1683	7	18	cardiovascular	cardiovascular	ADJ
can-1683	7	19	medications	medication	NOUN
can-1683	7	20	in	in	ADP
can-1683	7	21	the	the	DET
can-1683	7	22	future	future	NOUN
can-1683	7	23	.	.	PUNCT
can-1683	8	1	in	in	ADP
can-1683	8	2	addition	addition	NOUN
can-1683	8	3	,	,	PUNCT
can-1683	8	4	the	the	DET
can-1683	8	5	evaluation	evaluation	NOUN
can-1683	8	6	addressed	address	VERB
can-1683	8	7	the	the	DET
can-1683	8	8	drug	drug	NOUN
can-1683	8	9	’s	’s	PART
can-1683	8	10	safety	safety	NOUN
can-1683	8	11	.	.	PUNCT
can-1683	9	1	keywords	keyword	NOUN
can-1683	9	2	:	:	PUNCT
can-1683	9	3	nano	nano	NOUN
can-1683	9	4	-	-	PUNCT
can-1683	9	5	drug	drug	NOUN
can-1683	9	6	delivery	delivery	NOUN
can-1683	9	7	system	system	NOUN
can-1683	9	8	;	;	PUNCT
can-1683	9	9	cardiovascular	cardiovascular	ADJ
can-1683	9	10	disease	disease	NOUN
can-1683	9	11	;	;	PUNCT
can-1683	9	12	targeting	target	VERB
can-1683	9	13	strategy	strategy	NOUN
can-1683	9	14	;	;	PUNCT
can-1683	9	15	application	application	NOUN
can-1683	9	16	progress	progress	NOUN
can-1683	9	17	;	;	PUNCT
can-1683	9	18	safety	safety	NOUN
can-1683	9	19	article	article	NOUN
can-1683	9	20	info	info	NOUN
can-1683	9	21	received	receive	VERB
can-1683	9	22	:	:	PUNCT
can-1683	9	23	3	3	NUM
can-1683	9	24	may	may	AUX
can-1683	9	25	2022	2022	NUM
can-1683	9	26	accepted	accept	VERB
can-1683	9	27	:	:	PUNCT
can-1683	9	28	30	30	NUM
can-1683	9	29	june	june	PROPN
can-1683	9	30	2022	2022	NUM
can-1683	9	31	available	available	ADJ
can-1683	9	32	online	online	ADV
can-1683	9	33	:	:	PUNCT
can-1683	9	34	14	14	NUM
can-1683	9	35	july	july	PROPN
can-1683	9	36	2022	2022	NUM
can-1683	9	37	copyright	copyright	NOUN
can-1683	9	38	copyright	copyright	NOUN
can-1683	9	39	©	©	ADP
can-1683	9	40	2022	2022	NUM
can-1683	9	41	ramaiyan	ramaiyan	ADJ
can-1683	9	42	velmurugan	velmurugan	NOUN
can-1683	9	43	,	,	PUNCT
can-1683	9	44	et	et	PROPN
can-1683	9	45	al	al	PROPN
can-1683	9	46	.	.	PROPN
can-1683	9	47	enpress	enpress	PROPN
can-1683	9	48	publisher	publisher	PROPN
can-1683	9	49	llc	llc	PROPN
can-1683	9	50	.	.	PUNCT
can-1683	10	1	this	this	DET
can-1683	10	2	work	work	NOUN
can-1683	10	3	is	be	AUX
can-1683	10	4	licensed	license	VERB
can-1683	10	5	under	under	ADP
can-1683	10	6	the	the	DET
can-1683	10	7	creative	creative	ADJ
can-1683	10	8	commons	common	NOUN
can-1683	10	9	attribution	attribution	NOUN
can-1683	10	10	-	-	PUNCT
can-1683	10	11	noncommercial	noncommercial	ADJ
can-1683	10	12	4.0	4.0	NUM
can-1683	10	13	international	international	ADJ
can-1683	10	14	license	license	NOUN
can-1683	10	15	(	(	PUNCT
can-1683	10	16	cc	cc	NOUN
can-1683	10	17	by	by	ADP
can-1683	10	18	-	-	PUNCT
can-1683	10	19	nc	nc	PROPN
can-1683	10	20	4.0	4.0	NUM
can-1683	10	21	)	)	PUNCT
can-1683	10	22	.	.	PUNCT
can-1683	11	1	https://creativecommons.org/licenses/by-nc/	https://creativecommons.org/licenses/by-nc/	PROPN
can-1683	11	2	4.0/	4.0/	NUM
can-1683	11	3	1	1	NUM
can-1683	11	4	.	.	PUNCT
can-1683	12	1	introduction	introduction	NOUN
can-1683	12	2	cvds	cvds	PROPN
can-1683	12	3	have	have	AUX
can-1683	12	4	become	become	VERB
can-1683	12	5	a	a	DET
can-1683	12	6	major	major	ADJ
can-1683	12	7	public	public	ADJ
can-1683	12	8	health	health	NOUN
can-1683	12	9	issue	issue	NOUN
can-1683	12	10	across	across	ADP
can-1683	12	11	the	the	DET
can-1683	12	12	world	world	NOUN
can-1683	12	13	,	,	PUNCT
can-1683	12	14	and	and	CCONJ
can-1683	12	15	their	their	PRON
can-1683	12	16	morbidity	morbidity	NOUN
can-1683	12	17	and	and	CCONJ
can-1683	12	18	death	death	NOUN
can-1683	12	19	ranks	rank	VERB
can-1683	12	20	number	number	NOUN
can-1683	12	21	1	1	NUM
can-1683	12	22	among	among	ADP
can-1683	12	23	all	all	DET
can-1683	12	24	other	other	ADJ
can-1683	12	25	diseases	disease	NOUN
can-1683	12	26	in	in	ADP
can-1683	12	27	the	the	DET
can-1683	12	28	globe[1	globe[1	NOUN
can-1683	12	29	]	]	PUNCT
can-1683	12	30	.	.	PUNCT
can-1683	13	1	development	development	NOUN
can-1683	13	2	of	of	ADP
can-1683	13	3	medications	medication	NOUN
can-1683	13	4	for	for	ADP
can-1683	13	5	the	the	DET
can-1683	13	6	treatment	treatment	NOUN
can-1683	13	7	of	of	ADP
can-1683	13	8	cvd	cvd	PROPN
can-1683	13	9	is	be	AUX
can-1683	13	10	now	now	ADV
can-1683	13	11	a	a	DET
can-1683	13	12	primary	primary	ADJ
can-1683	13	13	focus	focus	NOUN
can-1683	13	14	.	.	PUNCT
can-1683	14	1	new	new	ADJ
can-1683	14	2	ways	way	NOUN
can-1683	14	3	of	of	ADP
can-1683	14	4	treating	treat	VERB
can-1683	14	5	cardiovascular	cardiovascular	ADJ
can-1683	14	6	illness	illness	NOUN
can-1683	14	7	have	have	AUX
can-1683	14	8	emerged	emerge	VERB
can-1683	14	9	as	as	ADP
can-1683	14	10	a	a	DET
can-1683	14	11	result	result	NOUN
can-1683	14	12	of	of	ADP
can-1683	14	13	the	the	DET
can-1683	14	14	rapid	rapid	ADJ
can-1683	14	15	advances	advance	NOUN
can-1683	14	16	in	in	ADP
can-1683	14	17	nanoscience	nanoscience	NOUN
can-1683	14	18	and	and	CCONJ
can-1683	14	19	nanomaterials	nanomaterial	NOUN
can-1683	14	20	’	'	PUNCT
can-1683	14	21	exceptional	exceptional	ADJ
can-1683	14	22	performance	performance	NOUN
can-1683	14	23	.	.	PUNCT
can-1683	15	1	to	to	PART
can-1683	15	2	enhance	enhance	VERB
can-1683	15	3	the	the	DET
can-1683	15	4	safety	safety	NOUN
can-1683	15	5	and	and	CCONJ
can-1683	15	6	efficacy	efficacy	NOUN
can-1683	15	7	of	of	ADP
can-1683	15	8	pharmaceuticals	pharmaceutical	NOUN
can-1683	15	9	,	,	PUNCT
can-1683	15	10	researchers	researcher	NOUN
can-1683	15	11	use	use	VERB
can-1683	15	12	nddss	nddss	NOUN
can-1683	15	13	,	,	PUNCT
can-1683	15	14	a	a	DET
can-1683	15	15	family	family	NOUN
can-1683	15	16	of	of	ADP
can-1683	15	17	nanomaterials	nanomaterial	NOUN
can-1683	15	18	that	that	PRON
can-1683	15	19	can	can	AUX
can-1683	15	20	boost	boost	VERB
can-1683	15	21	drug	drug	NOUN
can-1683	15	22	stability	stability	NOUN
can-1683	15	23	and	and	CCONJ
can-1683	15	24	water	water	NOUN
can-1683	15	25	solubility	solubility	NOUN
can-1683	15	26	,	,	PUNCT
can-1683	15	27	extend	extend	VERB
can-1683	15	28	the	the	DET
can-1683	15	29	cycle	cycle	NOUN
can-1683	15	30	duration	duration	NOUN
can-1683	15	31	,	,	PUNCT
can-1683	15	32	raise	raise	VERB
can-1683	15	33	the	the	DET
can-1683	15	34	absorption	absorption	NOUN
can-1683	15	35	rate	rate	NOUN
can-1683	15	36	of	of	ADP
can-1683	15	37	target	target	NOUN
can-1683	15	38	cells	cell	NOUN
can-1683	15	39	or	or	CCONJ
can-1683	15	40	tissues	tissue	NOUN
can-1683	15	41	,	,	PUNCT
can-1683	15	42	and	and	CCONJ
can-1683	15	43	limit	limit	VERB
can-1683	15	44	enzyme	enzyme	NOUN
can-1683	15	45	degradation[2	degradation[2	PROPN
can-1683	15	46	]	]	PUNCT
can-1683	15	47	.	.	PUNCT
can-1683	16	1	as	as	SCONJ
can-1683	16	2	nddss	nddss	NOUN
can-1683	16	3	may	may	AUX
can-1683	16	4	be	be	AUX
can-1683	16	5	supplied	supply	VERB
can-1683	16	6	by	by	ADP
can-1683	16	7	a	a	DET
can-1683	16	8	variety	variety	NOUN
can-1683	16	9	of	of	ADP
can-1683	16	10	methods	method	NOUN
can-1683	16	11	,	,	PUNCT
can-1683	16	12	such	such	ADJ
can-1683	16	13	as	as	ADP
can-1683	16	14	inhalation	inhalation	NOUN
can-1683	16	15	or	or	CCONJ
can-1683	16	16	intravenous	intravenous	ADJ
can-1683	16	17	injection	injection	NOUN
can-1683	16	18	,	,	PUNCT
can-1683	16	19	their	their	PRON
can-1683	16	20	bioavailability	bioavailability	NOUN
can-1683	16	21	is	be	AUX
can-1683	16	22	improved	improve	VERB
can-1683	16	23	.	.	PUNCT
can-1683	17	1	more	more	ADJ
can-1683	17	2	researchers	researcher	NOUN
can-1683	17	3	have	have	AUX
can-1683	17	4	begun	begin	VERB
can-1683	17	5	to	to	PART
can-1683	17	6	create	create	VERB
can-1683	17	7	nano	nano	NOUN
can-1683	17	8	-	-	PUNCT
can-1683	17	9	drug	drug	NOUN
can-1683	17	10	carrier	carrier	NOUN
can-1683	17	11	systems	system	NOUN
can-1683	17	12	for	for	ADP
can-1683	17	13	the	the	DET
can-1683	17	14	detection	detection	NOUN
can-1683	17	15	and	and	CCONJ
can-1683	17	16	treatment	treatment	NOUN
can-1683	17	17	of	of	ADP
can-1683	17	18	cardiovascular	cardiovascular	ADJ
can-1683	17	19	diseases	disease	NOUN
can-1683	17	20	in	in	ADP
can-1683	17	21	the	the	DET
can-1683	17	22	last	last	ADJ
can-1683	17	23	few	few	ADJ
can-1683	17	24	years	year	NOUN
can-1683	17	25	.	.	PUNCT
can-1683	18	1	furthermore	furthermore	ADV
can-1683	18	2	,	,	PUNCT
can-1683	18	3	when	when	SCONJ
can-1683	18	4	the	the	DET
can-1683	18	5	use	use	NOUN
can-1683	18	6	of	of	ADP
can-1683	18	7	nanomaterials	nanomaterial	NOUN
can-1683	18	8	in	in	ADP
can-1683	18	9	clinical	clinical	ADJ
can-1683	18	10	applications	application	NOUN
can-1683	18	11	develops	develop	VERB
can-1683	18	12	,	,	PUNCT
can-1683	18	13	the	the	DET
can-1683	18	14	risk	risk	NOUN
can-1683	18	15	of	of	ADP
can-1683	18	16	exposure	exposure	NOUN
can-1683	18	17	to	to	ADP
can-1683	18	18	nanomaterials	nanomaterial	NOUN
can-1683	18	19	in	in	ADP
can-1683	18	20	blood	blood	NOUN
can-1683	18	21	vessels	vessel	NOUN
can-1683	18	22	,	,	PUNCT
can-1683	18	23	blood	blood	NOUN
can-1683	18	24	,	,	PUNCT
can-1683	18	25	and	and	CCONJ
can-1683	18	26	their	their	PRON
can-1683	18	27	components	component	NOUN
can-1683	18	28	increases	increase	NOUN
can-1683	18	29	,	,	PUNCT
can-1683	18	30	which	which	PRON
can-1683	18	31	will	will	AUX
can-1683	18	32	have	have	VERB
can-1683	18	33	a	a	DET
can-1683	18	34	significant	significant	ADJ
can-1683	18	35	influence	influence	NOUN
can-1683	18	36	on	on	ADP
can-1683	18	37	human	human	ADJ
can-1683	18	38	health	health	NOUN
can-1683	18	39	as	as	ADP
can-1683	18	40	a	a	DET
can-1683	18	41	result	result	NOUN
can-1683	18	42	.	.	PUNCT
can-1683	19	1	consequently	consequently	ADV
can-1683	19	2	,	,	PUNCT
can-1683	19	3	this	this	DET
can-1683	19	4	paper	paper	NOUN
can-1683	19	5	focused	focus	VERB
can-1683	19	6	on	on	ADP
can-1683	19	7	nddss	nddss	NOUN
can-1683	19	8	,	,	PUNCT
can-1683	19	9	their	their	PRON
can-1683	19	10	targeting	targeting	NOUN
can-1683	19	11	methodologies	methodology	NOUN
can-1683	19	12	,	,	PUNCT
can-1683	19	13	and	and	CCONJ
can-1683	19	14	their	their	PRON
can-1683	19	15	application	application	NOUN
can-1683	19	16	in	in	ADP
can-1683	19	17	cvds	cvds	PROPN
can-1683	19	18	,	,	PUNCT
can-1683	19	19	as	as	ADV
can-1683	19	20	well	well	ADV
can-1683	19	21	as	as	ADP
can-1683	19	22	the	the	DET
can-1683	19	23	safety	safety	NOUN
can-1683	19	24	of	of	ADP
can-1683	19	25	nanomaterials	nanomaterial	NOUN
can-1683	19	26	.	.	PUNCT
can-1683	20	1	2	2	X
can-1683	20	2	.	.	X
can-1683	20	3	classifications	classification	NOUN
can-1683	20	4	of	of	ADP
can-1683	20	5	nddss	nddss	NOUN
can-1683	20	6	to	to	PART
can-1683	20	7	add	add	VERB
can-1683	20	8	to	to	ADP
can-1683	20	9	this	this	PRON
can-1683	20	10	,	,	PUNCT
can-1683	20	11	nanomaterials	nanomaterial	NOUN
can-1683	20	12	will	will	AUX
can-1683	20	13	have	have	VERB
can-1683	20	14	more	more	ADJ
can-1683	20	15	opportunities	opportunity	NOUN
can-1683	20	16	to	to	PART
can-1683	20	17	inter	inter	VERB
can-1683	20	18	10	10	NUM
can-1683	20	19	act	act	NOUN
can-1683	20	20	with	with	ADP
can-1683	20	21	blood	blood	NOUN
can-1683	20	22	vessels	vessel	NOUN
can-1683	20	23	,	,	PUNCT
can-1683	20	24	blood	blood	NOUN
can-1683	20	25	,	,	PUNCT
can-1683	20	26	and	and	CCONJ
can-1683	20	27	their	their	PRON
can-1683	20	28	components	component	NOUN
can-1683	20	29	as	as	SCONJ
can-1683	20	30	they	they	PRON
can-1683	20	31	become	become	VERB
can-1683	20	32	more	more	ADV
can-1683	20	33	widely	widely	ADV
can-1683	20	34	used	use	VERB
can-1683	20	35	in	in	ADP
can-1683	20	36	clinical	clinical	ADJ
can-1683	20	37	applications	application	NOUN
can-1683	20	38	.	.	PUNCT
can-1683	21	1	this	this	PRON
can-1683	21	2	means	mean	VERB
can-1683	21	3	that	that	SCONJ
can-1683	21	4	nanomaterials	nanomaterial	NOUN
can-1683	21	5	will	will	AUX
can-1683	21	6	have	have	VERB
can-1683	21	7	a	a	DET
can-1683	21	8	greater	great	ADJ
can-1683	21	9	impact	impact	NOUN
can-1683	21	10	on	on	ADP
can-1683	21	11	human	human	ADJ
can-1683	21	12	health	health	NOUN
can-1683	21	13	as	as	SCONJ
can-1683	21	14	they	they	PRON
can-1683	21	15	become	become	VERB
can-1683	21	16	more	more	ADV
can-1683	21	17	widely	widely	ADV
can-1683	21	18	used	use	VERB
can-1683	21	19	in	in	ADP
can-1683	21	20	clinical	clinical	ADJ
can-1683	21	21	applications	application	NOUN
can-1683	21	22	.	.	PUNCT
can-1683	22	1	consequently	consequently	ADV
can-1683	22	2	,	,	PUNCT
can-1683	22	3	this	this	DET
can-1683	22	4	paper	paper	NOUN
can-1683	22	5	focused	focus	VERB
can-1683	22	6	on	on	ADP
can-1683	22	7	nddss	nddss	NOUN
can-1683	22	8	,	,	PUNCT
can-1683	22	9	their	their	PRON
can-1683	22	10	targeting	targeting	NOUN
can-1683	22	11	methodologies	methodology	NOUN
can-1683	22	12	,	,	PUNCT
can-1683	22	13	and	and	CCONJ
can-1683	22	14	their	their	PRON
can-1683	22	15	application	application	NOUN
can-1683	22	16	in	in	ADP
can-1683	22	17	cvds	cvds	PROPN
can-1683	22	18	,	,	PUNCT
can-1683	22	19	as	as	ADV
can-1683	22	20	well	well	ADV
can-1683	22	21	as	as	ADP
can-1683	22	22	the	the	DET
can-1683	22	23	safety	safety	NOUN
can-1683	22	24	of	of	ADP
can-1683	22	25	nanomaterials	nanomaterial	NOUN
can-1683	22	26	.	.	PUNCT
can-1683	23	1	2.1	2.1	NUM
can-1683	23	2	liposomes	liposome	NOUN
can-1683	23	3	liposomes	liposome	NOUN
can-1683	23	4	are	be	AUX
can-1683	23	5	lipid	lipid	ADJ
can-1683	23	6	vesicles	vesicle	NOUN
can-1683	23	7	with	with	ADP
can-1683	23	8	a	a	DET
can-1683	23	9	cell	cell	NOUN
can-1683	23	10	-	-	PUNCT
can-1683	23	11	like	like	ADJ
can-1683	23	12	structure	structure	NOUN
can-1683	23	13	generated	generate	VERB
can-1683	23	14	by	by	ADP
can-1683	23	15	an	an	DET
can-1683	23	16	organized	organized	ADJ
can-1683	23	17	phospholipid	phospholipid	NOUN
can-1683	23	18	bilayer[3	bilayer[3	NOUN
can-1683	23	19	]	]	PUNCT
can-1683	23	20	.	.	PUNCT
can-1683	24	1	as	as	ADP
can-1683	24	2	a	a	DET
can-1683	24	3	form	form	NOUN
can-1683	24	4	of	of	ADP
can-1683	24	5	drug	drug	NOUN
can-1683	24	6	carrier	carrier	NOUN
can-1683	24	7	,	,	PUNCT
can-1683	24	8	liposomes	liposome	NOUN
can-1683	24	9	demonstrate	demonstrate	VERB
can-1683	24	10	a	a	DET
can-1683	24	11	number	number	NOUN
can-1683	24	12	of	of	ADP
can-1683	24	13	advantages	advantage	NOUN
can-1683	24	14	,	,	PUNCT
can-1683	24	15	such	such	ADJ
can-1683	24	16	as	as	ADP
can-1683	24	17	non	non	ADJ
can-1683	24	18	-	-	NOUN
can-1683	24	19	toxicity	toxicity	ADJ
can-1683	24	20	,	,	PUNCT
can-1683	24	21	non	non	ADJ
can-1683	24	22	-	-	NOUN
can-1683	24	23	immunogenicity	immunogenicity	NOUN
can-1683	24	24	,	,	PUNCT
can-1683	24	25	and	and	CCONJ
can-1683	24	26	long	long	ADJ
can-1683	24	27	-	-	PUNCT
can-1683	24	28	term	term	NOUN
can-1683	24	29	drug	drug	NOUN
can-1683	24	30	release	release	NOUN
can-1683	24	31	,	,	PUNCT
can-1683	24	32	as	as	ADV
can-1683	24	33	well	well	ADV
can-1683	24	34	as	as	ADP
can-1683	24	35	modifying	modify	VERB
can-1683	24	36	drug	drug	NOUN
can-1683	24	37	distribution	distribution	NOUN
can-1683	24	38	in	in	ADP
can-1683	24	39	vivo	vivo	NOUN
can-1683	24	40	,	,	PUNCT
can-1683	24	41	enhancing	enhance	VERB
can-1683	24	42	the	the	DET
can-1683	24	43	treatment	treatment	NOUN
can-1683	24	44	index	index	NOUN
can-1683	24	45	,	,	PUNCT
can-1683	24	46	and	and	CCONJ
can-1683	24	47	minimizing	minimize	VERB
can-1683	24	48	the	the	DET
can-1683	24	49	risks	risk	NOUN
can-1683	24	50	associated	associate	VERB
can-1683	24	51	with	with	ADP
can-1683	24	52	drug	drug	NOUN
can-1683	24	53	interactions	interaction	NOUN
can-1683	24	54	.	.	PUNCT
can-1683	25	1	in	in	ADP
can-1683	25	2	addition	addition	NOUN
can-1683	25	3	to	to	ADP
can-1683	25	4	being	be	AUX
can-1683	25	5	simple	simple	ADJ
can-1683	25	6	to	to	PART
can-1683	25	7	make	make	VERB
can-1683	25	8	,	,	PUNCT
can-1683	25	9	liposomes	liposome	NOUN
can-1683	25	10	may	may	AUX
can-1683	25	11	also	also	ADV
can-1683	25	12	be	be	AUX
can-1683	25	13	used	use	VERB
can-1683	25	14	to	to	PART
can-1683	25	15	encapsulate	encapsulate	VERB
can-1683	25	16	hydrophilic	hydrophilic	ADJ
can-1683	25	17	and	and	CCONJ
can-1683	25	18	ionic	ionic	ADJ
can-1683	25	19	compounds	compound	NOUN
can-1683	25	20	,	,	PUNCT
can-1683	25	21	as	as	ADV
can-1683	25	22	well	well	ADV
can-1683	25	23	as	as	ADP
can-1683	25	24	hydrophobic	hydrophobic	NOUN
can-1683	25	25	medicines[4	medicines[4	PRON
can-1683	25	26	]	]	PUNCT
can-1683	25	27	.	.	PUNCT
can-1683	26	1	phospholipids	phospholipid	NOUN
can-1683	26	2	and	and	CCONJ
can-1683	26	3	liposomes	liposome	NOUN
can-1683	26	4	can	can	AUX
can-1683	26	5	be	be	AUX
can-1683	26	6	used	use	VERB
can-1683	26	7	to	to	PART
can-1683	26	8	encase	encase	VERB
can-1683	26	9	hydrophobic	hydrophobic	NOUN
can-1683	26	10	medications	medication	NOUN
can-1683	26	11	,	,	PUNCT
can-1683	26	12	whereas	whereas	SCONJ
can-1683	26	13	liposomes	liposome	NOUN
can-1683	26	14	can	can	AUX
can-1683	26	15	encase	encase	VERB
can-1683	26	16	hydrophilic	hydrophilic	ADJ
can-1683	26	17	pharmaceuticals	pharmaceutical	NOUN
can-1683	26	18	,	,	PUNCT
can-1683	26	19	such	such	ADJ
can-1683	26	20	as	as	ADP
can-1683	26	21	those	those	PRON
can-1683	26	22	carrying	carry	VERB
can-1683	26	23	genes	gene	NOUN
can-1683	26	24	.	.	PUNCT
can-1683	27	1	material	material	NOUN
can-1683	27	2	modifications	modification	NOUN
can-1683	27	3	can	can	AUX
can-1683	27	4	change	change	VERB
can-1683	27	5	particle	particle	NOUN
can-1683	27	6	size	size	NOUN
can-1683	27	7	,	,	PUNCT
can-1683	27	8	potential	potential	ADJ
can-1683	27	9	and	and	CCONJ
can-1683	27	10	surface	surface	NOUN
can-1683	27	11	chemistry	chemistry	NOUN
can-1683	27	12	.	.	PUNCT
can-1683	28	1	these	these	DET
can-1683	28	2	liposomes	liposome	NOUN
can-1683	28	3	,	,	PUNCT
can-1683	28	4	known	know	VERB
can-1683	28	5	as	as	ADP
can-1683	28	6	cationic	cationic	ADJ
can-1683	28	7	liposomes	liposome	NOUN
can-1683	28	8	,	,	PUNCT
can-1683	28	9	are	be	AUX
can-1683	28	10	positively	positively	ADV
can-1683	28	11	charged	charge	VERB
can-1683	28	12	,	,	PUNCT
can-1683	28	13	which	which	PRON
can-1683	28	14	indicates	indicate	VERB
can-1683	28	15	that	that	SCONJ
can-1683	28	16	they	they	PRON
can-1683	28	17	may	may	AUX
can-1683	28	18	cause	cause	VERB
can-1683	28	19	dose	dose	NOUN
can-1683	28	20	-	-	PUNCT
can-1683	28	21	dependent	dependent	ADJ
can-1683	28	22	cell	cell	NOUN
can-1683	28	23	death	death	NOUN
can-1683	28	24	and	and	CCONJ
can-1683	28	25	inflammation	inflammation	NOUN
can-1683	28	26	,	,	PUNCT
can-1683	28	27	and	and	CCONJ
can-1683	28	28	as	as	ADP
can-1683	28	29	a	a	DET
can-1683	28	30	sort	sort	NOUN
can-1683	28	31	of	of	ADP
can-1683	28	32	complex	complex	ADJ
can-1683	28	33	,	,	PUNCT
can-1683	28	34	they	they	PRON
can-1683	28	35	may	may	AUX
can-1683	28	36	interact	interact	VERB
can-1683	28	37	with	with	ADP
can-1683	28	38	negatively	negatively	ADV
can-1683	28	39	charged	charge	VERB
can-1683	28	40	serum	serum	NOUN
can-1683	28	41	proteins	protein	NOUN
can-1683	28	42	in	in	ADP
can-1683	28	43	an	an	DET
can-1683	28	44	untargeted	untargeted	ADJ
can-1683	28	45	manner	manner	NOUN
can-1683	28	46	.	.	PUNCT
can-1683	29	1	these	these	DET
can-1683	29	2	issues	issue	NOUN
can-1683	29	3	can	can	AUX
can-1683	29	4	be	be	AUX
can-1683	29	5	addressed	address	VERB
can-1683	29	6	by	by	ADP
can-1683	29	7	neutral	neutral	ADJ
can-1683	29	8	lipids	lipid	NOUN
can-1683	29	9	and	and	CCONJ
can-1683	29	10	ph	ph	ADJ
can-1683	29	11	-	-	ADJ
can-1683	29	12	sensitive	sensitive	ADJ
can-1683	29	13	liposomes[5	liposomes[5	NOUN
can-1683	29	14	]	]	PUNCT
can-1683	29	15	.	.	PUNCT
can-1683	30	1	2.2	2.2	NUM
can-1683	30	2	polymer	polymer	NOUN
can-1683	30	3	micellar	micellar	ADJ
can-1683	30	4	co	co	NOUN
can-1683	30	5	-	-	NOUN
can-1683	30	6	delivery	delivery	NOUN
can-1683	30	7	system	system	NOUN
can-1683	30	8	it	it	PRON
can-1683	30	9	is	be	AUX
can-1683	30	10	possible	possible	ADJ
can-1683	30	11	to	to	PART
can-1683	30	12	categorize	categorize	VERB
can-1683	30	13	polymer	polymer	NOUN
can-1683	30	14	nanoparticles	nanoparticle	NOUN
can-1683	30	15	into	into	ADP
can-1683	30	16	non	non	ADJ
can-1683	30	17	-	-	ADJ
can-1683	30	18	biodegradable	biodegradable	ADJ
can-1683	30	19	materials	material	NOUN
can-1683	30	20	and	and	CCONJ
can-1683	30	21	biodegradable	biodegradable	ADJ
can-1683	30	22	materials	material	NOUN
can-1683	30	23	for	for	ADP
can-1683	30	24	the	the	DET
can-1683	30	25	delivery	delivery	NOUN
can-1683	30	26	of	of	ADP
can-1683	30	27	drugs	drug	NOUN
can-1683	30	28	.	.	PUNCT
can-1683	31	1	poly(lactic	poly(lactic	NOUN
can-1683	31	2	-	-	PUNCT
can-1683	31	3	co	co	NOUN
can-1683	31	4	-	-	ADJ
can-1683	31	5	glycolic	glycolic	ADJ
can-1683	31	6	acid	acid	NOUN
can-1683	31	7	)	)	PUNCT
can-1683	31	8	(	(	PUNCT
can-1683	31	9	plga	plga	NOUN
can-1683	31	10	)	)	PUNCT
can-1683	31	11	,	,	PUNCT
can-1683	31	12	polyvinyl	polyvinyl	NOUN
can-1683	31	13	imine	imine	NOUN
can-1683	31	14	(	(	PUNCT
can-1683	31	15	pei	pei	PROPN
can-1683	31	16	)	)	PUNCT
can-1683	31	17	,	,	PUNCT
can-1683	31	18	polycaprolactone	polycaprolactone	NOUN
can-1683	31	19	(	(	PUNCT
can-1683	31	20	pcl	pcl	PROPN
can-1683	31	21	)	)	PUNCT
can-1683	31	22	,	,	PUNCT
can-1683	31	23	and	and	CCONJ
can-1683	31	24	polyvinyl	polyvinyl	NOUN
can-1683	31	25	alcohol	alcohol	NOUN
can-1683	31	26	(	(	PUNCT
can-1683	31	27	pva	pva	NOUN
can-1683	31	28	)	)	PUNCT
can-1683	31	29	are	be	AUX
can-1683	31	30	examples	example	NOUN
can-1683	31	31	of	of	ADP
can-1683	31	32	synthetic	synthetic	ADJ
can-1683	31	33	polymer	polymer	NOUN
can-1683	31	34	materials	material	NOUN
can-1683	31	35	.	.	PUNCT
can-1683	32	1	biocompatibility	biocompatibility	NOUN
can-1683	32	2	,	,	PUNCT
can-1683	32	3	nontoxicity	nontoxicity	NOUN
can-1683	32	4	,	,	PUNCT
can-1683	32	5	and	and	CCONJ
can-1683	32	6	teratogenicity	teratogenicity	NOUN
can-1683	32	7	are	be	AUX
can-1683	32	8	all	all	PRON
can-1683	32	9	demonstrated	demonstrate	VERB
can-1683	32	10	by	by	ADP
can-1683	32	11	these	these	DET
can-1683	32	12	polymers	polymer	NOUN
can-1683	32	13	.	.	PUNCT
can-1683	33	1	oligomerization	oligomerization	NOUN
can-1683	33	2	and	and	CCONJ
can-1683	33	3	final	final	ADJ
can-1683	33	4	products	product	NOUN
can-1683	33	5	of	of	ADP
can-1683	33	6	degradation	degradation	NOUN
can-1683	33	7	have	have	VERB
can-1683	33	8	no	no	DET
can-1683	33	9	harmful	harmful	ADJ
can-1683	33	10	effects	effect	NOUN
can-1683	33	11	on	on	ADP
can-1683	33	12	cells	cell	NOUN
can-1683	33	13	and	and	CCONJ
can-1683	33	14	can	can	AUX
can-1683	33	15	coexist	coexist	VERB
can-1683	33	16	peacefully	peacefully	ADV
can-1683	33	17	with	with	ADP
can-1683	33	18	the	the	DET
can-1683	33	19	majority	majority	NOUN
can-1683	33	20	of	of	ADP
can-1683	33	21	medications	medication	NOUN
can-1683	33	22	.	.	PUNCT
can-1683	34	1	polysaccharides	polysaccharide	NOUN
can-1683	34	2	,	,	PUNCT
can-1683	34	3	peptides	peptide	NOUN
can-1683	34	4	,	,	PUNCT
can-1683	34	5	chol	chol	NOUN
can-1683	34	6	,	,	PUNCT
can-1683	34	7	and	and	CCONJ
can-1683	34	8	cyclodextrin	cyclodextrin	NOUN
can-1683	34	9	inclusion	inclusion	NOUN
can-1683	34	10	complexes	complex	NOUN
can-1683	34	11	are	be	AUX
can-1683	34	12	the	the	DET
can-1683	34	13	most	most	ADV
can-1683	34	14	common	common	ADJ
can-1683	34	15	types	type	NOUN
can-1683	34	16	of	of	ADP
can-1683	34	17	natural	natural	ADJ
can-1683	34	18	polymers[6	polymers[6	NOUN
can-1683	34	19	]	]	X
can-1683	34	20	,	,	PUNCT
can-1683	34	21	although	although	SCONJ
can-1683	34	22	there	there	PRON
can-1683	34	23	are	be	VERB
can-1683	34	24	many	many	ADJ
can-1683	34	25	others	other	NOUN
can-1683	34	26	.	.	PUNCT
can-1683	35	1	amphiphilic	amphiphilic	ADJ
can-1683	35	2	block	block	NOUN
can-1683	35	3	copolymers	copolymer	NOUN
can-1683	35	4	,	,	PUNCT
can-1683	35	5	which	which	PRON
can-1683	35	6	comprise	comprise	VERB
can-1683	35	7	the	the	DET
can-1683	35	8	core	core	NOUN
can-1683	35	9	of	of	ADP
can-1683	35	10	polymer	polymer	NOUN
can-1683	35	11	nanoparticles	nanoparticle	NOUN
can-1683	35	12	,	,	PUNCT
can-1683	35	13	can	can	AUX
can-1683	35	14	be	be	AUX
can-1683	35	15	employed	employ	VERB
can-1683	35	16	to	to	PART
can-1683	35	17	intercept	intercept	VERB
can-1683	35	18	insoluble	insoluble	ADJ
can-1683	35	19	medicines	medicine	NOUN
can-1683	35	20	through	through	ADP
can-1683	35	21	self	self	NOUN
can-1683	35	22	-	-	PUNCT
can-1683	35	23	assembly[7	assembly[7	NUM
can-1683	35	24	]	]	PUNCT
can-1683	35	25	.	.	PUNCT
can-1683	36	1	particle	particle	NOUN
can-1683	36	2	size	size	NOUN
can-1683	36	3	uniformity	uniformity	NOUN
can-1683	36	4	and	and	CCONJ
can-1683	36	5	drug	drug	NOUN
can-1683	36	6	release	release	NOUN
can-1683	36	7	control	control	NOUN
can-1683	36	8	may	may	AUX
can-1683	36	9	be	be	AUX
can-1683	36	10	improved	improve	VERB
can-1683	36	11	by	by	ADP
can-1683	36	12	the	the	DET
can-1683	36	13	stable	stable	ADJ
can-1683	36	14	structure	structure	NOUN
can-1683	36	15	of	of	ADP
can-1683	36	16	polymer	polymer	NOUN
can-1683	36	17	nanoparticles	nanoparticle	NOUN
can-1683	36	18	,	,	PUNCT
can-1683	36	19	which	which	PRON
can-1683	36	20	can	can	AUX
can-1683	36	21	effectively	effectively	ADV
can-1683	36	22	withstand	withstand	VERB
can-1683	36	23	the	the	DET
can-1683	36	24	effects	effect	NOUN
can-1683	36	25	of	of	ADP
can-1683	36	26	gastrointestinal	gastrointestinal	ADJ
can-1683	36	27	environment	environment	NOUN
can-1683	36	28	during	during	ADP
can-1683	36	29	oral	oral	ADJ
can-1683	36	30	delivery[8	delivery[8	NOUN
can-1683	36	31	]	]	PUNCT
can-1683	36	32	.	.	PUNCT
can-1683	37	1	drug	drug	NOUN
can-1683	37	2	absorption	absorption	NOUN
can-1683	37	3	is	be	AUX
can-1683	37	4	enhanced	enhance	VERB
can-1683	37	5	by	by	ADP
can-1683	37	6	their	their	PRON
can-1683	37	7	small	small	ADJ
can-1683	37	8	size	size	NOUN
can-1683	37	9	and	and	CCONJ
can-1683	37	10	wide	wide	ADJ
can-1683	37	11	surface	surface	NOUN
can-1683	37	12	area	area	NOUN
can-1683	37	13	,	,	PUNCT
can-1683	37	14	which	which	PRON
can-1683	37	15	facilitates	facilitate	VERB
can-1683	37	16	greater	great	ADJ
can-1683	37	17	bioavailability	bioavailability	NOUN
can-1683	37	18	.	.	PUNCT
can-1683	38	1	polymer	polymer	NOUN
can-1683	38	2	nanoparticles	nanoparticle	NOUN
can-1683	38	3	,	,	PUNCT
can-1683	38	4	however	however	ADV
can-1683	38	5	,	,	PUNCT
can-1683	38	6	not	not	PART
can-1683	38	7	all	all	PRON
can-1683	38	8	of	of	ADP
can-1683	38	9	them	they	PRON
can-1683	38	10	are	be	AUX
can-1683	38	11	created	create	VERB
can-1683	38	12	equal	equal	ADJ
can-1683	38	13	.	.	PUNCT
can-1683	39	1	since	since	SCONJ
can-1683	39	2	chitosan	chitosan	NOUN
can-1683	39	3	,	,	PUNCT
can-1683	39	4	a	a	DET
can-1683	39	5	naturally	naturally	ADV
can-1683	39	6	occurring	occur	VERB
can-1683	39	7	polymer	polymer	NOUN
can-1683	39	8	,	,	PUNCT
can-1683	39	9	is	be	AUX
can-1683	39	10	incompatible	incompatible	ADJ
can-1683	39	11	with	with	ADP
can-1683	39	12	biological	biological	ADJ
can-1683	39	13	fluids	fluid	NOUN
can-1683	39	14	,	,	PUNCT
can-1683	39	15	it	it	PRON
can-1683	39	16	can	can	AUX
can-1683	39	17	lead	lead	VERB
can-1683	39	18	to	to	ADP
can-1683	39	19	particle	particle	NOUN
can-1683	39	20	disintegration	disintegration	NOUN
can-1683	39	21	and	and	CCONJ
can-1683	39	22	lower	low	ADJ
can-1683	39	23	operating	operating	NOUN
can-1683	39	24	efficiency	efficiency	NOUN
can-1683	39	25	.	.	PUNCT
can-1683	40	1	its	its	PRON
can-1683	40	2	deficit	deficit	NOUN
can-1683	40	3	can	can	AUX
can-1683	40	4	be	be	AUX
can-1683	40	5	remedied	remedie	VERB
can-1683	40	6	structurally	structurally	ADV
can-1683	40	7	.	.	PUNCT
can-1683	41	1	the	the	DET
can-1683	41	2	conjugate	conjugate	NOUN
can-1683	41	3	’s	’s	PART
can-1683	41	4	endocytosis	endocytosis	NOUN
can-1683	41	5	and	and	CCONJ
can-1683	41	6	macrophage	macrophage	ADJ
can-1683	41	7	phagocytosis	phagocytosis	NOUN
can-1683	41	8	mechanisms	mechanism	NOUN
can-1683	41	9	are	be	AUX
can-1683	41	10	unusual	unusual	ADJ
can-1683	41	11	since	since	SCONJ
can-1683	41	12	they	they	PRON
can-1683	41	13	combine	combine	VERB
can-1683	41	14	chitosan	chitosan	NOUN
can-1683	41	15	and	and	CCONJ
can-1683	41	16	polyethylene	polyethylene	NOUN
can-1683	41	17	glycol	glycol	NOUN
can-1683	41	18	.	.	PUNCT
can-1683	42	1	furthermore	furthermore	ADV
can-1683	42	2	,	,	PUNCT
can-1683	42	3	the	the	DET
can-1683	42	4	addition	addition	NOUN
can-1683	42	5	of	of	ADP
can-1683	42	6	a	a	DET
can-1683	42	7	polypeptide	polypeptide	NOUN
can-1683	42	8	to	to	ADP
can-1683	42	9	chitosan	chitosan	NOUN
can-1683	42	10	can	can	AUX
can-1683	42	11	increase	increase	VERB
can-1683	42	12	its	its	PRON
can-1683	42	13	working	work	VERB
can-1683	42	14	efficiency[9	efficiency[9	NOUN
can-1683	42	15	]	]	PUNCT
can-1683	42	16	.	.	PUNCT
can-1683	43	1	2.3	2.3	NUM
can-1683	43	2	dendritic	dendritic	ADJ
can-1683	43	3	macromolecules	macromolecule	NOUN
can-1683	43	4	synthetic	synthetic	ADJ
can-1683	43	5	macromolecules	macromolecule	NOUN
can-1683	43	6	may	may	AUX
can-1683	43	7	take	take	VERB
can-1683	43	8	on	on	ADP
can-1683	43	9	a	a	DET
can-1683	43	10	variety	variety	NOUN
can-1683	43	11	of	of	ADP
can-1683	43	12	shapes	shape	NOUN
can-1683	43	13	and	and	CCONJ
can-1683	43	14	are	be	AUX
can-1683	43	15	frequently	frequently	ADV
can-1683	43	16	branched	branch	VERB
can-1683	43	17	.	.	PUNCT
can-1683	44	1	nano	nano	NOUN
can-1683	44	2	-	-	PUNCT
can-1683	44	3	carriers	carrier	NOUN
can-1683	44	4	,	,	PUNCT
can-1683	44	5	such	such	ADJ
can-1683	44	6	as	as	ADP
can-1683	44	7	macromolecules	macromolecule	NOUN
can-1683	44	8	structured	structure	VERB
can-1683	44	9	like	like	ADP
can-1683	44	10	spheres	sphere	NOUN
can-1683	44	11	,	,	PUNCT
can-1683	44	12	can	can	AUX
can-1683	44	13	be	be	AUX
can-1683	44	14	utilized	utilize	VERB
can-1683	44	15	to	to	PART
can-1683	44	16	administer	administer	VERB
can-1683	44	17	and	and	CCONJ
can-1683	44	18	dissolve	dissolve	VERB
can-1683	44	19	insoluble	insoluble	ADJ
can-1683	44	20	medications	medication	NOUN
can-1683	44	21	in	in	ADP
can-1683	44	22	a	a	DET
can-1683	44	23	monodisperse	monodisperse	NOUN
can-1683	44	24	environment	environment	NOUN
can-1683	44	25	.	.	PUNCT
can-1683	45	1	in	in	ADP
can-1683	45	2	addition	addition	NOUN
can-1683	45	3	to	to	ADP
can-1683	45	4	being	be	AUX
can-1683	45	5	monodispersed	monodisperse	VERB
can-1683	45	6	,	,	PUNCT
can-1683	45	7	dendritic	dendritic	ADJ
can-1683	45	8	macromolecules	macromolecule	NOUN
can-1683	45	9	with	with	ADP
can-1683	45	10	a	a	DET
can-1683	45	11	unique	unique	ADJ
can-1683	45	12	branch	branch	NOUN
can-1683	45	13	structure	structure	NOUN
can-1683	45	14	also	also	ADV
can-1683	45	15	have	have	VERB
can-1683	45	16	a	a	DET
can-1683	45	17	variable	variable	ADJ
can-1683	45	18	molecular	molecular	ADJ
can-1683	45	19	weight	weight	NOUN
can-1683	45	20	.	.	PUNCT
can-1683	46	1	in	in	ADP
can-1683	46	2	addition	addition	NOUN
can-1683	46	3	,	,	PUNCT
can-1683	46	4	the	the	DET
can-1683	46	5	package	package	NOUN
can-1683	46	6	has	have	VERB
can-1683	46	7	a	a	DET
can-1683	46	8	significant	significant	ADJ
can-1683	46	9	number	number	NOUN
can-1683	46	10	of	of	ADP
can-1683	46	11	pre	pre	ADJ
can-1683	46	12	-	-	ADJ
can-1683	46	13	made	make	VERB
can-1683	46	14	surface	surface	NOUN
can-1683	46	15	functional	functional	ADJ
can-1683	46	16	groups	group	NOUN
can-1683	46	17	and	and	CCONJ
can-1683	46	18	a	a	DET
can-1683	46	19	hydrophobic	hydrophobic	NOUN
can-1683	46	20	environment	environment	NOUN
can-1683	46	21	,	,	PUNCT
can-1683	46	22	making	make	VERB
can-1683	46	23	it	it	PRON
can-1683	46	24	an	an	DET
can-1683	46	25	ideal	ideal	ADJ
can-1683	46	26	drug	drug	NOUN
can-1683	46	27	delivery	delivery	NOUN
can-1683	46	28	medium[10	medium[10	NOUN
can-1683	46	29	]	]	PUNCT
can-1683	46	30	.	.	PUNCT
can-1683	47	1	dendritic	dendritic	ADJ
can-1683	47	2	macromolecules	macromolecule	NOUN
can-1683	47	3	are	be	AUX
can-1683	47	4	frequently	frequently	ADV
can-1683	47	5	employed	employ	VERB
can-1683	47	6	in	in	ADP
can-1683	47	7	the	the	DET
can-1683	47	8	biomedical	biomedical	ADJ
can-1683	47	9	and	and	CCONJ
can-1683	47	10	pharmaceutical	pharmaceutical	NOUN
can-1683	47	11	industries	industry	NOUN
can-1683	47	12	because	because	SCONJ
can-1683	47	13	of	of	ADP
can-1683	47	14	their	their	PRON
can-1683	47	15	good	good	ADJ
can-1683	47	16	biological	biological	ADJ
can-1683	47	17	characteristics	characteristic	NOUN
can-1683	47	18	,	,	PUNCT
can-1683	47	19	however	however	ADV
can-1683	47	20	,	,	PUNCT
can-1683	47	21	the	the	DET
can-1683	47	22	presence	presence	NOUN
can-1683	47	23	of	of	ADP
can-1683	47	24	a	a	DET
can-1683	47	25	surface	surface	NOUN
can-1683	47	26	cationic	cationic	ADJ
can-1683	47	27	charge	charge	NOUN
can-1683	47	28	also	also	ADV
can-1683	47	29	restricts	restrict	VERB
can-1683	47	30	their	their	PRON
can-1683	47	31	clinical	clinical	ADJ
can-1683	47	32	applicability	applicability	NOUN
can-1683	47	33	.	.	PUNCT
can-1683	48	1	2.4	2.4	NUM
can-1683	48	2	metal	metal	NOUN
can-1683	48	3	nanomaterials	nanomaterial	NOUN
can-1683	48	4	there	there	PRON
can-1683	48	5	are	be	VERB
can-1683	48	6	a	a	DET
can-1683	48	7	wide	wide	ADJ
can-1683	48	8	variety	variety	NOUN
can-1683	48	9	of	of	ADP
can-1683	48	10	metal	metal	NOUN
can-1683	48	11	nanomaterials	nanomaterial	NOUN
can-1683	48	12	that	that	PRON
can-1683	48	13	can	can	AUX
can-1683	48	14	be	be	AUX
can-1683	48	15	separated	separate	VERB
can-1683	48	16	into	into	ADP
can-1683	48	17	/	/	SYM
can-1683	48	18	like	like	ADJ
can-1683	48	19	gold	gold	NOUN
can-1683	48	20	,	,	PUNCT
can-1683	48	21	silver	silver	NOUN
can-1683	48	22	,	,	PUNCT
can-1683	48	23	and	and	CCONJ
can-1683	48	24	11	11	NUM
can-1683	48	25	platinum	platinum	NOUN
can-1683	48	26	nanomaterials	nanomaterial	NOUN
can-1683	48	27	,	,	PUNCT
can-1683	48	28	each	each	PRON
can-1683	48	29	of	of	ADP
can-1683	48	30	which	which	PRON
can-1683	48	31	may	may	AUX
can-1683	48	32	be	be	AUX
can-1683	48	33	categorized	categorize	VERB
can-1683	48	34	into	into	ADP
can-1683	48	35	/	/	SYM
can-1683	48	36	like	like	ADJ
can-1683	48	37	nanoparticles	nanoparticle	NOUN
can-1683	48	38	,	,	PUNCT
can-1683	48	39	rods	rod	NOUN
can-1683	48	40	,	,	PUNCT
can-1683	48	41	capsules	capsule	NOUN
can-1683	48	42	,	,	PUNCT
can-1683	48	43	nanocuboids	nanocuboid	NOUN
can-1683	48	44	,	,	PUNCT
can-1683	48	45	and	and	CCONJ
can-1683	48	46	wire[11	wire[11	ADP
can-1683	48	47	]	]	PUNCT
can-1683	48	48	.	.	PUNCT
can-1683	49	1	gold	gold	ADJ
can-1683	49	2	nanoparticles	nanoparticle	NOUN
can-1683	49	3	are	be	AUX
can-1683	49	4	employed	employ	VERB
can-1683	49	5	in	in	ADP
can-1683	49	6	photothermal	photothermal	ADJ
can-1683	49	7	therapy	therapy	NOUN
can-1683	49	8	of	of	ADP
can-1683	49	9	malignancies	malignancy	NOUN
can-1683	49	10	and	and	CCONJ
can-1683	49	11	rheumatoid	rheumatoid	VERB
can-1683	49	12	arthritis	arthritis	NOUN
can-1683	49	13	in	in	ADP
can-1683	49	14	addition	addition	NOUN
can-1683	49	15	to	to	ADP
can-1683	49	16	being	be	AUX
can-1683	49	17	a	a	DET
can-1683	49	18	nano	nano	NOUN
can-1683	49	19	-	-	PUNCT
can-1683	49	20	contrast	contrast	NOUN
can-1683	49	21	agent	agent	NOUN
can-1683	49	22	for	for	ADP
can-1683	49	23	ct	ct	PROPN
can-1683	49	24	and	and	CCONJ
can-1683	49	25	surface	surface	NOUN
can-1683	49	26	-	-	PUNCT
can-1683	49	27	enhanced	enhance	VERB
can-1683	49	28	raman	raman	NOUN
can-1683	49	29	spectroscopy	spectroscopy	NOUN
can-1683	49	30	.	.	PUNCT
can-1683	50	1	antibacterial	antibacterial	ADJ
can-1683	50	2	,	,	PUNCT
can-1683	50	3	anti	anti	ADJ
can-1683	50	4	-	-	ADJ
can-1683	50	5	infection	infection	ADJ
can-1683	50	6	,	,	PUNCT
can-1683	50	7	and	and	CCONJ
can-1683	50	8	anti	anti	ADJ
can-1683	50	9	-	-	ADJ
can-1683	50	10	tumor	tumor	NOUN
can-1683	50	11	are	be	AUX
can-1683	50	12	among	among	ADP
can-1683	50	13	the	the	DET
can-1683	50	14	various	various	ADJ
can-1683	50	15	uses	use	NOUN
can-1683	50	16	for	for	ADP
can-1683	50	17	silver	silver	ADJ
can-1683	50	18	nanoparticles	nanoparticle	NOUN
can-1683	50	19	that	that	PRON
can-1683	50	20	have	have	AUX
can-1683	50	21	been	be	AUX
can-1683	50	22	demonstrated	demonstrate	VERB
can-1683	50	23	in	in	ADP
can-1683	50	24	several	several	ADJ
can-1683	50	25	studies	study	NOUN
can-1683	50	26	.	.	PUNCT
can-1683	51	1	another	another	DET
can-1683	51	2	option	option	NOUN
can-1683	51	3	is	be	AUX
can-1683	51	4	to	to	PART
can-1683	51	5	use	use	VERB
can-1683	51	6	hollow	hollow	ADJ
can-1683	51	7	nanostructures	nanostructure	NOUN
can-1683	51	8	to	to	PART
can-1683	51	9	hold	hold	VERB
can-1683	51	10	therapeutic	therapeutic	ADJ
can-1683	51	11	pharmaceuticals[12	pharmaceuticals[12	NOUN
can-1683	51	12	]	]	PUNCT
can-1683	51	13	or	or	CCONJ
can-1683	51	14	chemically	chemically	ADV
can-1683	51	15	bind	bind	VERB
can-1683	51	16	them	they	PRON
can-1683	51	17	to	to	ADP
can-1683	51	18	the	the	DET
can-1683	51	19	surface	surface	NOUN
can-1683	51	20	of	of	ADP
can-1683	51	21	nanoparticles	nanoparticle	NOUN
can-1683	51	22	to	to	PART
can-1683	51	23	transport	transport	VERB
can-1683	51	24	the	the	DET
can-1683	51	25	medications	medication	NOUN
can-1683	51	26	.	.	PUNCT
can-1683	52	1	gold	gold	NOUN
can-1683	52	2	and	and	CCONJ
can-1683	52	3	silver	silver	ADJ
can-1683	52	4	nanoparticles	nanoparticle	NOUN
can-1683	52	5	can	can	AUX
can-1683	52	6	be	be	AUX
can-1683	52	7	used	use	VERB
can-1683	52	8	to	to	PART
can-1683	52	9	treat	treat	VERB
can-1683	52	10	chronic	chronic	ADJ
can-1683	52	11	illnesses	illness	NOUN
can-1683	52	12	,	,	PUNCT
can-1683	52	13	however	however	ADV
can-1683	52	14	,	,	PUNCT
can-1683	52	15	the	the	DET
can-1683	52	16	elimination	elimination	NOUN
can-1683	52	17	of	of	ADP
can-1683	52	18	gold	gold	ADJ
can-1683	52	19	nanomaterials	nanomaterial	NOUN
can-1683	52	20	in	in	ADP
can-1683	52	21	the	the	DET
can-1683	52	22	human	human	ADJ
can-1683	52	23	body	body	NOUN
can-1683	52	24	is	be	AUX
can-1683	52	25	too	too	ADV
can-1683	52	26	slow	slow	ADJ
can-1683	52	27	,	,	PUNCT
can-1683	52	28	and	and	CCONJ
can-1683	52	29	silver	silver	ADJ
can-1683	52	30	ions	ion	NOUN
can-1683	52	31	are	be	AUX
can-1683	52	32	poisonous	poisonous	ADJ
can-1683	52	33	in	in	ADP
can-1683	52	34	vivo	vivo	NOUN
can-1683	52	35	.	.	PUNCT
can-1683	53	1	2.5	2.5	NUM
can-1683	53	2	inorganic	inorganic	ADJ
can-1683	53	3	non	non	ADJ
can-1683	53	4	-	-	ADJ
can-1683	53	5	metallic	metallic	ADJ
can-1683	53	6	nanomaterials	nanomaterial	NOUN
can-1683	53	7	there	there	PRON
can-1683	53	8	are	be	VERB
can-1683	53	9	a	a	DET
can-1683	53	10	wide	wide	ADJ
can-1683	53	11	variety	variety	NOUN
can-1683	53	12	of	of	ADP
can-1683	53	13	nonmetallic	nonmetallic	ADJ
can-1683	53	14	inorganic	inorganic	ADJ
can-1683	53	15	nanomaterials	nanomaterial	NOUN
can-1683	53	16	,	,	PUNCT
can-1683	53	17	such	such	ADJ
can-1683	53	18	as	as	ADP
can-1683	53	19	quantum	quantum	ADJ
can-1683	53	20	dots	dot	NOUN
can-1683	53	21	,	,	PUNCT
can-1683	53	22	iron	iron	NOUN
can-1683	53	23	oxide	oxide	NOUN
can-1683	53	24	,	,	PUNCT
can-1683	53	25	silicon	silicon	NOUN
can-1683	53	26	,	,	PUNCT
can-1683	53	27	and	and	CCONJ
can-1683	53	28	grapheme	grapheme	NOUN
can-1683	53	29	for	for	ADP
can-1683	53	30	example[13	example[13	NOUN
can-1683	53	31	]	]	PUNCT
can-1683	53	32	.	.	PUNCT
can-1683	54	1	fluorescence	fluorescence	PROPN
can-1683	54	2	imaging	imaging	PROPN
can-1683	54	3	with	with	ADP
can-1683	54	4	qds	qds	PROPN
can-1683	54	5	,	,	PUNCT
can-1683	54	6	or	or	CCONJ
can-1683	54	7	semiconductor	semiconductor	NOUN
can-1683	54	8	nanocrystals	nanocrystal	NOUN
can-1683	54	9	,	,	PUNCT
can-1683	54	10	is	be	AUX
can-1683	54	11	the	the	DET
can-1683	54	12	primary	primary	ADJ
can-1683	54	13	focus	focus	NOUN
can-1683	54	14	of	of	ADP
can-1683	54	15	qd	qd	NOUN
can-1683	54	16	research	research	NOUN
can-1683	54	17	,	,	PUNCT
can-1683	54	18	whereas	whereas	SCONJ
can-1683	54	19	iron	iron	NOUN
can-1683	54	20	oxide	oxide	NOUN
can-1683	54	21	nanoparticles	nanoparticle	NOUN
can-1683	54	22	are	be	AUX
can-1683	54	23	being	be	AUX
can-1683	54	24	exploited	exploit	VERB
can-1683	54	25	to	to	PART
can-1683	54	26	develop	develop	VERB
can-1683	54	27	novel	novel	ADJ
can-1683	54	28	mri	mri	NOUN
can-1683	54	29	contrast	contrast	NOUN
can-1683	54	30	agents	agent	NOUN
can-1683	54	31	.	.	PUNCT
can-1683	55	1	because	because	SCONJ
can-1683	55	2	of	of	ADP
can-1683	55	3	their	their	PRON
can-1683	55	4	enormous	enormous	ADJ
can-1683	55	5	surface	surface	NOUN
can-1683	55	6	area	area	NOUN
can-1683	55	7	and	and	CCONJ
can-1683	55	8	porous	porous	ADJ
can-1683	55	9	structure	structure	NOUN
can-1683	55	10	,	,	PUNCT
can-1683	55	11	mesoporous	mesoporous	ADJ
can-1683	55	12	silicon	silicon	NOUN
can-1683	55	13	nanoparticles	nanoparticle	NOUN
can-1683	55	14	have	have	AUX
can-1683	55	15	become	become	VERB
can-1683	55	16	increasingly	increasingly	ADV
can-1683	55	17	popular	popular	ADJ
can-1683	55	18	in	in	ADP
can-1683	55	19	recent	recent	ADJ
can-1683	55	20	years	year	NOUN
can-1683	55	21	as	as	ADP
can-1683	55	22	a	a	DET
can-1683	55	23	therapeutic	therapeutic	ADJ
can-1683	55	24	tool	tool	NOUN
can-1683	55	25	.	.	PUNCT
can-1683	56	1	drugs	drug	NOUN
can-1683	56	2	and	and	CCONJ
can-1683	56	3	genes	gene	NOUN
can-1683	56	4	can	can	AUX
can-1683	56	5	be	be	AUX
can-1683	56	6	transported	transport	VERB
can-1683	56	7	more	more	ADV
can-1683	56	8	efficiently	efficiently	ADV
can-1683	56	9	in	in	ADP
can-1683	56	10	mammalian	mammalian	ADJ
can-1683	56	11	cells	cell	NOUN
can-1683	56	12	by	by	ADP
can-1683	56	13	integrating	integrate	VERB
can-1683	56	14	diverse	diverse	ADJ
can-1683	56	15	functional	functional	ADJ
can-1683	56	16	groups	group	NOUN
can-1683	56	17	into	into	ADP
can-1683	56	18	inorganic	inorganic	ADJ
can-1683	56	19	nanomaterials	nanomaterial	NOUN
can-1683	56	20	.	.	PUNCT
can-1683	57	1	in	in	ADP
can-1683	57	2	the	the	DET
can-1683	57	3	meanwhile	meanwhile	NOUN
can-1683	57	4	,	,	PUNCT
can-1683	57	5	they	they	PRON
can-1683	57	6	’re	’re	AUX
can-1683	57	7	being	be	AUX
can-1683	57	8	touted	tout	VERB
can-1683	57	9	as	as	ADP
can-1683	57	10	a	a	DET
can-1683	57	11	type	type	NOUN
can-1683	57	12	of	of	ADP
can-1683	57	13	joint	joint	ADJ
can-1683	57	14	carrier	carrier	NOUN
can-1683	57	15	with	with	ADP
can-1683	57	16	room	room	NOUN
can-1683	57	17	for	for	ADP
can-1683	57	18	growth	growth	NOUN
can-1683	57	19	.	.	PUNCT
can-1683	58	1	however	however	ADV
can-1683	58	2	,	,	PUNCT
can-1683	58	3	the	the	DET
can-1683	58	4	bio	bio	NOUN
can-1683	58	5	-	-	PUNCT
can-1683	58	6	safety	safety	NOUN
can-1683	58	7	of	of	ADP
can-1683	58	8	inorganic	inorganic	ADJ
can-1683	58	9	non	non	ADJ
can-1683	58	10	-	-	ADJ
can-1683	58	11	metallic	metallic	ADJ
can-1683	58	12	nanoparticles	nanoparticle	NOUN
can-1683	58	13	would	would	AUX
can-1683	58	14	be	be	AUX
can-1683	58	15	a	a	DET
can-1683	58	16	significant	significant	ADJ
can-1683	58	17	barrier	barrier	NOUN
can-1683	58	18	to	to	ADP
can-1683	58	19	their	their	PRON
can-1683	58	20	clinical	clinical	ADJ
can-1683	58	21	use[14	use[14	PROPN
can-1683	58	22	]	]	PUNCT
can-1683	58	23	.	.	PUNCT
can-1683	59	1	2.6	2.6	NUM
can-1683	59	2	composite	composite	ADJ
can-1683	59	3	nanomaterials	nanomaterial	NOUN
can-1683	59	4	additionally	additionally	ADV
can-1683	59	5	,	,	PUNCT
can-1683	59	6	several	several	ADJ
can-1683	59	7	research	research	NOUN
can-1683	59	8	are	be	AUX
can-1683	59	9	focusing	focus	VERB
can-1683	59	10	on	on	ADP
can-1683	59	11	the	the	DET
can-1683	59	12	development	development	NOUN
can-1683	59	13	of	of	ADP
can-1683	59	14	composite	composite	ADJ
can-1683	59	15	nanomaterials	nanomaterial	NOUN
can-1683	59	16	with	with	ADP
can-1683	59	17	a	a	DET
can-1683	59	18	variety	variety	NOUN
can-1683	59	19	of	of	ADP
can-1683	59	20	characteristics	characteristic	NOUN
can-1683	59	21	.	.	PUNCT
can-1683	60	1	to	to	PART
can-1683	60	2	generate	generate	VERB
can-1683	60	3	multifunctional	multifunctional	ADJ
can-1683	60	4	nddss	nddss	NOUN
can-1683	60	5	,	,	PUNCT
can-1683	60	6	for	for	ADP
can-1683	60	7	example	example	NOUN
can-1683	60	8	,	,	PUNCT
can-1683	60	9	metal	metal	NOUN
can-1683	60	10	or	or	CCONJ
can-1683	60	11	inorganic	inorganic	ADJ
can-1683	60	12	non	non	ADJ
can-1683	60	13	-	-	ADJ
can-1683	60	14	metallic	metallic	ADJ
can-1683	60	15	nanomaterials	nanomaterial	NOUN
can-1683	60	16	are	be	AUX
can-1683	60	17	inserted	insert	VERB
can-1683	60	18	into	into	ADP
can-1683	60	19	polymer	polymer	NOUN
can-1683	60	20	or	or	CCONJ
can-1683	60	21	lipid	lipid	NOUN
can-1683	60	22	nanoparticles	nanoparticle	NOUN
can-1683	60	23	.	.	PUNCT
can-1683	61	1	organic	organic	ADJ
can-1683	61	2	materials	material	NOUN
can-1683	61	3	are	be	AUX
can-1683	61	4	used	use	VERB
can-1683	61	5	to	to	PART
can-1683	61	6	decorate	decorate	VERB
can-1683	61	7	or	or	CCONJ
can-1683	61	8	modify	modify	VERB
can-1683	61	9	metal	metal	NOUN
can-1683	61	10	and	and	CCONJ
can-1683	61	11	inorganic	inorganic	ADJ
can-1683	61	12	nanomaterials	nanomaterial	NOUN
can-1683	61	13	to	to	PART
can-1683	61	14	improve	improve	VERB
can-1683	61	15	their	their	PRON
can-1683	61	16	physical	physical	ADJ
can-1683	61	17	and	and	CCONJ
can-1683	61	18	chemical	chemical	NOUN
can-1683	61	19	properties	property	NOUN
can-1683	61	20	,	,	PUNCT
can-1683	61	21	in	in	ADP
can-1683	61	22	vivo	vivo	ADJ
can-1683	61	23	kinetic	kinetic	ADJ
can-1683	61	24	behavior	behavior	NOUN
can-1683	61	25	,	,	PUNCT
can-1683	61	26	and	and	CCONJ
can-1683	61	27	biocompatibility	biocompatibility	NOUN
can-1683	61	28	,	,	PUNCT
can-1683	61	29	and	and	CCONJ
can-1683	61	30	some	some	DET
can-1683	61	31	nddss	nddss	NOUN
can-1683	61	32	with	with	ADP
can-1683	61	33	special	special	ADJ
can-1683	61	34	structure	structure	NOUN
can-1683	61	35	and	and	CCONJ
can-1683	61	36	diverse	diverse	ADJ
can-1683	61	37	functions	function	NOUN
can-1683	61	38	can	can	AUX
can-1683	61	39	be	be	AUX
can-1683	61	40	prepared	prepare	VERB
can-1683	61	41	by	by	ADP
can-1683	61	42	combining	combine	VERB
can-1683	61	43	different	different	ADJ
can-1683	61	44	metals	metal	NOUN
can-1683	61	45	and	and	CCONJ
can-1683	61	46	inorganic	inorganic	ADJ
can-1683	61	47	materials	material	NOUN
can-1683	61	48	.	.	PUNCT
can-1683	62	1	3	3	X
can-1683	62	2	.	.	X
can-1683	62	3	targeting	target	VERB
can-1683	62	4	strategy	strategy	NOUN
can-1683	62	5	of	of	ADP
can-1683	62	6	the	the	DET
can-1683	62	7	nddss	nddss	NOUN
can-1683	62	8	lesion	lesion	NOUN
can-1683	62	9	cells	cell	NOUN
can-1683	62	10	or	or	CCONJ
can-1683	62	11	tissues	tissue	NOUN
can-1683	62	12	of	of	ADP
can-1683	62	13	cvds	cvds	PROPN
can-1683	62	14	may	may	AUX
can-1683	62	15	also	also	ADV
can-1683	62	16	be	be	AUX
can-1683	62	17	targeted	target	VERB
can-1683	62	18	,	,	PUNCT
can-1683	62	19	making	make	VERB
can-1683	62	20	them	they	PRON
can-1683	62	21	easier	easy	ADJ
can-1683	62	22	to	to	PART
can-1683	62	23	target	target	VERB
can-1683	62	24	than	than	ADP
can-1683	62	25	tumor	tumor	NOUN
can-1683	62	26	tissues	tissue	NOUN
can-1683	62	27	that	that	PRON
can-1683	62	28	have	have	VERB
can-1683	62	29	various	various	ADJ
can-1683	62	30	physiological	physiological	ADJ
can-1683	62	31	hurdles	hurdle	NOUN
can-1683	62	32	to	to	PART
can-1683	62	33	overcome	overcome	VERB
can-1683	62	34	,	,	PUNCT
can-1683	62	35	according	accord	VERB
can-1683	62	36	to	to	ADP
can-1683	62	37	new	new	ADJ
can-1683	62	38	studies	study	NOUN
can-1683	62	39	in	in	ADP
can-1683	62	40	the	the	DET
can-1683	62	41	field	field	NOUN
can-1683	62	42	.	.	PUNCT
can-1683	63	1	if	if	SCONJ
can-1683	63	2	you	you	PRON
can-1683	63	3	’re	’re	AUX
can-1683	63	4	using	use	VERB
can-1683	63	5	nano	nano	NOUN
can-1683	63	6	-	-	PUNCT
can-1683	63	7	transporter	transporter	NOUN
can-1683	63	8	medications	medication	NOUN
can-1683	63	9	,	,	PUNCT
can-1683	63	10	the	the	DET
can-1683	63	11	time	time	NOUN
can-1683	63	12	it	it	PRON
can-1683	63	13	takes	take	VERB
can-1683	63	14	for	for	SCONJ
can-1683	63	15	them	they	PRON
can-1683	63	16	to	to	PART
can-1683	63	17	enter	enter	VERB
can-1683	63	18	the	the	DET
can-1683	63	19	bloodstream	bloodstream	NOUN
can-1683	63	20	may	may	AUX
can-1683	63	21	be	be	AUX
can-1683	63	22	longer	long	ADJ
can-1683	63	23	than	than	SCONJ
can-1683	63	24	if	if	SCONJ
can-1683	63	25	you	you	PRON
can-1683	63	26	were	be	AUX
can-1683	63	27	using	use	VERB
can-1683	63	28	traditional	traditional	ADJ
can-1683	63	29	pharmaceuticals	pharmaceutical	NOUN
can-1683	63	30	.	.	PUNCT
can-1683	64	1	it	it	PRON
can-1683	64	2	is	be	AUX
can-1683	64	3	possible	possible	ADJ
can-1683	64	4	to	to	PART
can-1683	64	5	alter	alter	VERB
can-1683	64	6	the	the	DET
can-1683	64	7	rate	rate	NOUN
can-1683	64	8	of	of	ADP
can-1683	64	9	those	those	DET
can-1683	64	10	targeted	target	VERB
can-1683	64	11	nano	nano	NOUN
can-1683	64	12	-	-	PUNCT
can-1683	64	13	transporter	transporter	NOUN
can-1683	64	14	medications	medication	NOUN
can-1683	64	15	by	by	ADP
can-1683	64	16	adjusting	adjust	VERB
can-1683	64	17	ph	ph	VERB
can-1683	64	18	,	,	PUNCT
can-1683	64	19	temperature	temperature	NOUN
can-1683	64	20	,	,	PUNCT
can-1683	64	21	light	light	NOUN
can-1683	64	22	,	,	PUNCT
can-1683	64	23	ultrasound	ultrasound	NOUN
can-1683	64	24	,	,	PUNCT
can-1683	64	25	or	or	CCONJ
can-1683	64	26	biological	biological	ADJ
can-1683	64	27	enzyme[15	enzyme[15	NOUN
can-1683	64	28	]	]	PUNCT
can-1683	64	29	.	.	PUNCT
can-1683	65	1	3.1	3.1	NUM
can-1683	65	2	passive	passive	ADJ
can-1683	65	3	target	target	NOUN
can-1683	65	4	transfer	transfer	NOUN
can-1683	65	5	enhanced	enhance	VERB
can-1683	65	6	vascular	vascular	ADJ
can-1683	65	7	permeability	permeability	NOUN
can-1683	65	8	high	high	ADJ
can-1683	65	9	permeability	permeability	NOUN
can-1683	65	10	and	and	CCONJ
can-1683	65	11	high	high	ADJ
can-1683	65	12	retention	retention	NOUN
can-1683	65	13	(	(	PUNCT
can-1683	65	14	epr	epr	ADJ
can-1683	65	15	)	)	PUNCT
can-1683	65	16	effects	effect	NOUN
can-1683	65	17	are	be	AUX
can-1683	65	18	the	the	DET
can-1683	65	19	primary	primary	ADJ
can-1683	65	20	means	mean	NOUN
can-1683	65	21	by	by	ADP
can-1683	65	22	which	which	PRON
can-1683	65	23	passive	passive	ADJ
can-1683	65	24	targeted	target	VERB
can-1683	65	25	transport	transport	NOUN
can-1683	65	26	is	be	AUX
can-1683	65	27	accomplished[16	accomplished[16	VERB
can-1683	65	28	]	]	PUNCT
can-1683	65	29	.	.	PUNCT
can-1683	66	1	there	there	PRON
can-1683	66	2	are	be	VERB
can-1683	66	3	some	some	DET
can-1683	66	4	chemicals	chemical	NOUN
can-1683	66	5	or	or	CCONJ
can-1683	66	6	particles	particle	NOUN
can-1683	66	7	that	that	PRON
can-1683	66	8	tend	tend	VERB
can-1683	66	9	to	to	PART
can-1683	66	10	collect	collect	VERB
can-1683	66	11	in	in	ADP
can-1683	66	12	tumor	tumor	NOUN
can-1683	66	13	tissues	tissue	NOUN
can-1683	66	14	,	,	PUNCT
can-1683	66	15	and	and	CCONJ
can-1683	66	16	this	this	PRON
can-1683	66	17	is	be	AUX
can-1683	66	18	known	know	VERB
can-1683	66	19	as	as	ADP
can-1683	66	20	epr	epr	PROPN
can-1683	66	21	.	.	PUNCT
can-1683	66	22	normal	normal	ADJ
can-1683	66	23	tissue	tissue	NOUN
can-1683	66	24	has	have	VERB
can-1683	66	25	a	a	DET
can-1683	66	26	thick	thick	ADJ
can-1683	66	27	and	and	CCONJ
can-1683	66	28	intact	intact	ADJ
can-1683	66	29	microvascular	microvascular	ADJ
can-1683	66	30	endothelial	endothelial	ADJ
can-1683	66	31	cell	cell	NOUN
can-1683	66	32	space	space	NOUN
can-1683	66	33	,	,	PUNCT
can-1683	66	34	making	make	VERB
can-1683	66	35	it	it	PRON
can-1683	66	36	difficult	difficult	ADJ
can-1683	66	37	to	to	PART
can-1683	66	38	pass	pass	VERB
can-1683	66	39	through	through	ADP
can-1683	66	40	the	the	DET
can-1683	66	41	vascular	vascular	ADJ
can-1683	66	42	wall	wall	NOUN
can-1683	66	43	nddss	nddss	ADV
can-1683	66	44	loaded	load	VERB
can-1683	66	45	with	with	ADP
can-1683	66	46	drugs	drug	NOUN
can-1683	66	47	of	of	ADP
can-1683	66	48	a	a	DET
can-1683	66	49	high	high	ADJ
can-1683	66	50	molecular	molecular	ADJ
can-1683	66	51	weight	weight	NOUN
can-1683	66	52	.	.	PUNCT
can-1683	67	1	despite	despite	SCONJ
can-1683	67	2	its	its	PRON
can-1683	67	3	high	high	ADJ
can-1683	67	4	blood	blood	NOUN
can-1683	67	5	artery	artery	NOUN
can-1683	67	6	density	density	NOUN
can-1683	67	7	,	,	PUNCT
can-1683	67	8	tumor	tumor	NOUN
can-1683	67	9	tissue	tissue	NOUN
can-1683	67	10	is	be	AUX
can-1683	67	11	structurally	structurally	ADV
can-1683	67	12	weak	weak	ADJ
can-1683	67	13	.	.	PUNCT
can-1683	68	1	high	high	ADJ
can-1683	68	2	molecular	molecular	ADJ
can-1683	68	3	weight	weight	NOUN
can-1683	68	4	nddss	nddss	NOUN
can-1683	68	5	loaded	load	VERB
can-1683	68	6	with	with	ADP
can-1683	68	7	drugs	drug	NOUN
can-1683	68	8	can	can	AUX
can-1683	68	9	preferentially	preferentially	ADV
can-1683	68	10	pass	pass	VERB
can-1683	68	11	through	through	ADP
can-1683	68	12	the	the	DET
can-1683	68	13	vascular	vascular	ADJ
can-1683	68	14	wall	wall	NOUN
can-1683	68	15	and	and	CCONJ
can-1683	68	16	stay	stay	VERB
can-1683	68	17	in	in	ADP
can-1683	68	18	the	the	DET
can-1683	68	19	tumor	tumor	NOUN
can-1683	68	20	tissue	tissue	NOUN
can-1683	68	21	.	.	PUNCT
can-1683	69	1	nano	nano	NOUN
can-1683	69	2	-	-	PUNCT
can-1683	69	3	drug	drug	NOUN
can-1683	69	4	carriers	carrier	NOUN
can-1683	69	5	with	with	ADP
can-1683	69	6	a	a	DET
can-1683	69	7	particle	particle	NOUN
can-1683	69	8	size	size	NOUN
can-1683	69	9	of	of	ADP
can-1683	69	10	less	less	ADJ
can-1683	69	11	than	than	ADP
can-1683	69	12	100	100	NUM
can-1683	69	13	nm	nm	NOUN
can-1683	69	14	have	have	AUX
can-1683	69	15	been	be	AUX
can-1683	69	16	proven	prove	VERB
can-1683	69	17	to	to	PART
can-1683	69	18	be	be	AUX
can-1683	69	19	able	able	ADJ
can-1683	69	20	to	to	PART
can-1683	69	21	find	find	VERB
can-1683	69	22	and	and	CCONJ
can-1683	69	23	target	target	VERB
can-1683	69	24	solid	solid	ADJ
can-1683	69	25	tumor	tumor	NOUN
can-1683	69	26	tissues	tissue	NOUN
can-1683	69	27	using	use	VERB
can-1683	69	28	epr	epr	PROPN
can-1683	69	29	.	.	PUNCT
can-1683	70	1	the	the	DET
can-1683	70	2	nano	nano	NOUN
can-1683	70	3	-	-	PUNCT
can-1683	70	4	drug	drug	NOUN
can-1683	70	5	carrier	carrier	NOUN
can-1683	70	6	can	can	AUX
can-1683	70	7	boost	boost	VERB
can-1683	70	8	the	the	DET
can-1683	70	9	drug	drug	NOUN
can-1683	70	10	’s	’s	PART
can-1683	70	11	bioavailability	bioavailability	NOUN
can-1683	70	12	by	by	ADP
can-1683	70	13	more	more	ADJ
can-1683	70	14	than	than	ADP
can-1683	70	15	ten	ten	NUM
can-1683	70	16	times	time	NOUN
can-1683	70	17	when	when	SCONJ
can-1683	70	18	compared	compare	VERB
can-1683	70	19	to	to	ADP
can-1683	70	20	the	the	DET
can-1683	70	21	direct	direct	ADJ
can-1683	70	22	delivery	delivery	NOUN
can-1683	70	23	approach[17	approach[17	PROPN
can-1683	70	24	]	]	PUNCT
can-1683	70	25	.	.	PUNCT
can-1683	71	1	however	however	ADV
can-1683	71	2	,	,	PUNCT
can-1683	71	3	it	it	PRON
can-1683	71	4	has	have	AUX
can-1683	71	5	been	be	AUX
can-1683	71	6	revealed	reveal	VERB
can-1683	71	7	that	that	SCONJ
can-1683	71	8	the	the	DET
can-1683	71	9	epr	epr	PROPN
can-1683	71	10	effect	effect	NOUN
can-1683	71	11	may	may	AUX
can-1683	71	12	be	be	AUX
can-1683	71	13	exploited	exploit	VERB
can-1683	71	14	to	to	PART
can-1683	71	15	treat	treat	VERB
can-1683	71	16	a	a	DET
can-1683	71	17	variety	variety	NOUN
can-1683	71	18	of	of	ADP
can-1683	71	19	cardiovascular	cardiovascular	ADJ
can-1683	71	20	diseases	disease	NOUN
can-1683	71	21	,	,	PUNCT
can-1683	71	22	not	not	PART
can-1683	71	23	just	just	ADV
can-1683	71	24	malignancies	malignancy	NOUN
can-1683	71	25	.	.	PUNCT
can-1683	72	1	to	to	PART
can-1683	72	2	provide	provide	VERB
can-1683	72	3	one	one	NUM
can-1683	72	4	example	example	NOUN
can-1683	72	5	,	,	PUNCT
can-1683	72	6	the	the	DET
can-1683	72	7	development	development	NOUN
can-1683	72	8	of	of	ADP
can-1683	72	9	as	as	ADP
can-1683	72	10	in	in	ADP
can-1683	72	11	some	some	DET
can-1683	72	12	cvds	cvds	NOUN
can-1683	72	13	may	may	AUX
can-1683	72	14	be	be	AUX
can-1683	72	15	traced	trace	VERB
can-1683	72	16	to	to	ADP
can-1683	72	17	an	an	DET
can-1683	72	18	ongoing	ongoing	ADJ
can-1683	72	19	inflammation	inflammation	NOUN
can-1683	72	20	that	that	PRON
can-1683	72	21	leads	lead	VERB
can-1683	72	22	to	to	ADP
can-1683	72	23	abnormally	abnormally	ADV
can-1683	72	24	high	high	ADJ
can-1683	72	25	levels	level	NOUN
can-1683	72	26	of	of	ADP
can-1683	72	27	blood	blood	NOUN
can-1683	72	28	vessel	vessel	NOUN
can-1683	72	29	permeability	permeability	NOUN
can-1683	72	30	—	—	PUNCT
can-1683	72	31	a	a	DET
can-1683	72	32	phenomenon	phenomenon	NOUN
can-1683	72	33	strikingly	strikingly	ADV
can-1683	72	34	similar	similar	ADJ
can-1683	72	35	to	to	ADP
can-1683	72	36	that	that	PRON
can-1683	72	37	seen	see	VERB
can-1683	72	38	in	in	ADP
can-1683	72	39	solid	solid	ADJ
can-1683	72	40	tumors	tumor	NOUN
can-1683	72	41	.	.	PUNCT
can-1683	73	1	for	for	ADP
can-1683	73	2	the	the	DET
can-1683	73	3	ndds	ndd	NOUN
can-1683	73	4	to	to	PART
can-1683	73	5	reach	reach	VERB
can-1683	73	6	the	the	DET
can-1683	73	7	inside	inside	NOUN
can-1683	73	8	of	of	ADP
can-1683	73	9	the	the	DET
can-1683	73	10	plaque	plaque	NOUN
can-1683	73	11	,	,	PUNCT
can-1683	73	12	vascu	vascu	NOUN
can-1683	73	13	12	12	NUM
can-1683	73	14	lar	lar	ADJ
can-1683	73	15	endothelial	endothelial	ADJ
can-1683	73	16	permeability	permeability	NOUN
can-1683	73	17	is	be	AUX
can-1683	73	18	a	a	DET
can-1683	73	19	crucial	crucial	ADJ
can-1683	73	20	factor	factor	NOUN
can-1683	73	21	in	in	ADP
can-1683	73	22	the	the	DET
can-1683	73	23	process	process	NOUN
can-1683	73	24	.	.	PUNCT
can-1683	74	1	aside	aside	ADV
can-1683	74	2	from	from	ADP
can-1683	74	3	being	be	AUX
can-1683	74	4	consumed	consume	VERB
can-1683	74	5	by	by	ADP
can-1683	74	6	inflammatory	inflammatory	ADJ
can-1683	74	7	cells	cell	NOUN
can-1683	74	8	(	(	PUNCT
can-1683	74	9	monocytes	monocyte	NOUN
can-1683	74	10	or	or	CCONJ
can-1683	74	11	macrophages	macrophage	NOUN
can-1683	74	12	)	)	PUNCT
can-1683	74	13	,	,	PUNCT
can-1683	74	14	nano	nano	NOUN
can-1683	74	15	-	-	PUNCT
can-1683	74	16	drug	drug	NOUN
can-1683	74	17	carriers	carrier	NOUN
can-1683	74	18	entering	enter	VERB
can-1683	74	19	the	the	DET
can-1683	74	20	blood	blood	NOUN
can-1683	74	21	are	be	AUX
can-1683	74	22	also	also	ADV
can-1683	74	23	taken	take	VERB
can-1683	74	24	up	up	ADP
can-1683	74	25	by	by	ADP
can-1683	74	26	these	these	DET
can-1683	74	27	cells	cell	NOUN
can-1683	74	28	,	,	PUNCT
can-1683	74	29	allowing	allow	VERB
can-1683	74	30	medications	medication	NOUN
can-1683	74	31	to	to	PART
can-1683	74	32	be	be	AUX
can-1683	74	33	given	give	VERB
can-1683	74	34	in	in	ADP
can-1683	74	35	a	a	DET
can-1683	74	36	different	different	ADJ
can-1683	74	37	manner[18	manner[18	PROPN
can-1683	74	38	]	]	PUNCT
can-1683	74	39	.	.	PUNCT
can-1683	75	1	nanomaterials	nanomaterial	NOUN
can-1683	75	2	are	be	AUX
can-1683	75	3	inappropriate	inappropriate	ADJ
can-1683	75	4	for	for	ADP
can-1683	75	5	medications	medication	NOUN
can-1683	75	6	with	with	ADP
can-1683	75	7	lengthy	lengthy	ADJ
can-1683	75	8	cycle	cycle	NOUN
can-1683	75	9	durations	duration	NOUN
can-1683	75	10	because	because	SCONJ
can-1683	75	11	of	of	ADP
can-1683	75	12	their	their	PRON
can-1683	75	13	quick	quick	ADJ
can-1683	75	14	clearance	clearance	NOUN
can-1683	75	15	from	from	ADP
can-1683	75	16	the	the	DET
can-1683	75	17	circulation	circulation	NOUN
can-1683	75	18	upon	upon	SCONJ
can-1683	75	19	intravenous	intravenous	ADJ
can-1683	75	20	administration	administration	NOUN
can-1683	75	21	due	due	ADP
can-1683	75	22	to	to	ADP
can-1683	75	23	their	their	PRON
can-1683	75	24	size	size	NOUN
can-1683	75	25	and	and	CCONJ
can-1683	75	26	surface	surface	NOUN
can-1683	75	27	properties	property	NOUN
can-1683	75	28	.	.	PUNCT
can-1683	76	1	the	the	DET
can-1683	76	2	nano	nano	NOUN
can-1683	76	3	-	-	PUNCT
can-1683	76	4	system	system	NOUN
can-1683	76	5	may	may	AUX
can-1683	76	6	be	be	AUX
can-1683	76	7	covered	cover	VERB
can-1683	76	8	over	over	ADP
can-1683	76	9	using	use	VERB
can-1683	76	10	nano	nano	NOUN
can-1683	76	11	-	-	PUNCT
can-1683	76	12	coating	coat	VERB
can-1683	76	13	technology	technology	NOUN
can-1683	76	14	,	,	PUNCT
can-1683	76	15	and	and	CCONJ
can-1683	76	16	the	the	DET
can-1683	76	17	rate	rate	NOUN
can-1683	76	18	at	at	ADP
can-1683	76	19	which	which	PRON
can-1683	76	20	the	the	DET
can-1683	76	21	coating	coat	VERB
can-1683	76	22	agent	agent	NOUN
can-1683	76	23	is	be	AUX
can-1683	76	24	administered	administer	VERB
can-1683	76	25	can	can	AUX
can-1683	76	26	be	be	AUX
can-1683	76	27	precisely	precisely	ADV
can-1683	76	28	regulated	regulate	VERB
can-1683	76	29	and	and	CCONJ
can-1683	76	30	changed	change	VERB
can-1683	76	31	.	.	PUNCT
can-1683	77	1	nddss	nddss	NOUN
can-1683	77	2	can	can	AUX
can-1683	77	3	benefit	benefit	VERB
can-1683	77	4	from	from	ADP
can-1683	77	5	this	this	DET
can-1683	77	6	technology	technology	NOUN
can-1683	77	7	in	in	ADP
can-1683	77	8	the	the	DET
can-1683	77	9	treatment	treatment	NOUN
can-1683	77	10	of	of	ADP
can-1683	77	11	cardiovascular	cardiovascular	ADJ
can-1683	77	12	disease	disease	NOUN
can-1683	77	13	.	.	PUNCT
can-1683	78	1	poly	poly	ADJ
can-1683	78	2	(	(	PUNCT
can-1683	78	3	ethylene	ethylene	NOUN
can-1683	78	4	glycol	glycol	NOUN
can-1683	78	5	)	)	PUNCT
can-1683	78	6	(	(	PUNCT
can-1683	78	7	peg	peg	NOUN
can-1683	78	8	)	)	PUNCT
can-1683	78	9	has	have	AUX
can-1683	78	10	been	be	AUX
can-1683	78	11	used	use	VERB
can-1683	78	12	in	in	ADP
can-1683	78	13	particle	particle	NOUN
can-1683	78	14	creation	creation	NOUN
can-1683	78	15	by	by	ADP
can-1683	78	16	ndds	ndd	NOUN
can-1683	78	17	developers	developer	NOUN
can-1683	78	18	.	.	PUNCT
can-1683	79	1	a	a	DET
can-1683	79	2	hydrophilic	hydrophilic	ADJ
can-1683	79	3	polymer	polymer	NOUN
can-1683	79	4	known	know	VERB
can-1683	79	5	as	as	ADP
can-1683	79	6	peg	peg	NOUN
can-1683	79	7	may	may	AUX
can-1683	79	8	be	be	AUX
can-1683	79	9	grafted	graft	VERB
can-1683	79	10	onto	onto	ADP
can-1683	79	11	any	any	DET
can-1683	79	12	surface	surface	NOUN
can-1683	79	13	to	to	PART
can-1683	79	14	create	create	VERB
can-1683	79	15	an	an	DET
can-1683	79	16	effective	effective	ADJ
can-1683	79	17	coating	coating	NOUN
can-1683	79	18	of	of	ADP
can-1683	79	19	water	water	NOUN
can-1683	79	20	that	that	PRON
can-1683	79	21	prevents	prevent	VERB
can-1683	79	22	proteins	protein	NOUN
can-1683	79	23	from	from	ADP
can-1683	79	24	adhering	adhere	VERB
can-1683	79	25	to	to	ADP
can-1683	79	26	the	the	DET
can-1683	79	27	surface	surface	NOUN
can-1683	79	28	.	.	PUNCT
can-1683	80	1	so	so	ADV
can-1683	80	2	that	that	PRON
can-1683	80	3	tissue	tissue	NOUN
can-1683	80	4	plasminogen	plasminogen	NOUN
can-1683	80	5	activator	activator	NOUN
can-1683	80	6	is	be	AUX
can-1683	80	7	protected	protect	VERB
can-1683	80	8	from	from	ADP
can-1683	80	9	plasma	plasma	NOUN
can-1683	80	10	inhibitor	inhibitor	NOUN
can-1683	80	11	inactivation	inactivation	NOUN
can-1683	80	12	and	and	CCONJ
can-1683	80	13	its	its	PRON
can-1683	80	14	half	half	ADJ
can-1683	80	15	-	-	PUNCT
can-1683	80	16	life	life	NOUN
can-1683	80	17	is	be	AUX
can-1683	80	18	prolonged	prolong	VERB
can-1683	80	19	.	.	PUNCT
can-1683	81	1	it	it	PRON
can-1683	81	2	is	be	AUX
can-1683	81	3	enclosed	enclose	VERB
can-1683	81	4	in	in	ADP
can-1683	81	5	nanoparticles	nanoparticle	NOUN
can-1683	81	6	that	that	PRON
can-1683	81	7	conceal	conceal	VERB
can-1683	81	8	the	the	DET
can-1683	81	9	nanosystem[19	nanosystem[19	NOUN
can-1683	81	10	]	]	X
can-1683	81	11	.	.	PUNCT
can-1683	82	1	3.2	3.2	NUM
can-1683	82	2	shear	shear	NOUN
can-1683	82	3	-	-	PUNCT
can-1683	82	4	induced	induced	ADJ
can-1683	82	5	targeting	targeting	NOUN
can-1683	82	6	for	for	ADP
can-1683	82	7	patients	patient	NOUN
can-1683	82	8	with	with	ADP
can-1683	82	9	severe	severe	ADJ
can-1683	82	10	coronary	coronary	ADJ
can-1683	82	11	artery	artery	NOUN
can-1683	82	12	disease	disease	NOUN
can-1683	82	13	(	(	PUNCT
can-1683	82	14	cad	cad	NOUN
can-1683	82	15	)	)	PUNCT
can-1683	82	16	,	,	PUNCT
can-1683	82	17	thrombosis	thrombosis	NOUN
can-1683	82	18	or	or	CCONJ
can-1683	82	19	microthrombus	microthrombus	ADJ
can-1683	82	20	formation	formation	NOUN
can-1683	82	21	develops	develop	VERB
can-1683	82	22	,	,	PUNCT
can-1683	82	23	which	which	PRON
can-1683	82	24	leads	lead	VERB
can-1683	82	25	to	to	ADP
can-1683	82	26	stenosis	stenosis	NOUN
can-1683	82	27	of	of	ADP
can-1683	82	28	the	the	DET
can-1683	82	29	blood	blood	NOUN
can-1683	82	30	arteries	artery	NOUN
can-1683	82	31	,	,	PUNCT
can-1683	82	32	which	which	PRON
can-1683	82	33	restricts	restrict	VERB
can-1683	82	34	blood	blood	NOUN
can-1683	82	35	flow	flow	NOUN
can-1683	82	36	through	through	ADP
can-1683	82	37	the	the	DET
can-1683	82	38	plaque	plaque	NOUN
can-1683	82	39	,	,	PUNCT
can-1683	82	40	and	and	CCONJ
can-1683	82	41	therefore	therefore	ADV
can-1683	82	42	raises	raise	VERB
can-1683	82	43	the	the	DET
can-1683	82	44	fluid	fluid	ADJ
can-1683	82	45	shear	shear	NOUN
can-1683	82	46	stress	stress	NOUN
can-1683	82	47	.	.	PUNCT
can-1683	83	1	compared	compare	VERB
can-1683	83	2	to	to	ADP
can-1683	83	3	the	the	DET
can-1683	83	4	normal	normal	ADJ
can-1683	83	5	vasculature	vasculature	NOUN
can-1683	83	6	,	,	PUNCT
can-1683	83	7	the	the	DET
can-1683	83	8	blood	blood	NOUN
can-1683	83	9	fluid	fluid	ADJ
can-1683	83	10	shear	shear	NOUN
can-1683	83	11	force	force	NOUN
can-1683	83	12	in	in	ADP
can-1683	83	13	the	the	PRON
can-1683	83	14	as	as	SCONJ
can-1683	83	15	plaque	plaque	NOUN
can-1683	83	16	stenosis	stenosis	NOUN
can-1683	83	17	can	can	AUX
can-1683	83	18	reach	reach	VERB
can-1683	83	19	up	up	ADP
can-1683	83	20	to	to	PART
can-1683	83	21	1,000	1,000	NUM
can-1683	83	22	dyne·cm2	dyne·cm2	NOUN
can-1683	83	23	on	on	ADP
can-1683	83	24	a	a	DET
can-1683	83	25	daily	daily	ADJ
can-1683	83	26	basis[20	basis[20	NOUN
can-1683	83	27	]	]	PUNCT
can-1683	83	28	.	.	PUNCT
can-1683	84	1	as	as	ADP
can-1683	84	2	a	a	DET
can-1683	84	3	result	result	NOUN
can-1683	84	4	,	,	PUNCT
can-1683	84	5	the	the	DET
can-1683	84	6	difference	difference	NOUN
can-1683	84	7	in	in	ADP
can-1683	84	8	blood	blood	NOUN
can-1683	84	9	fluid	fluid	ADJ
can-1683	84	10	shear	shear	NOUN
can-1683	84	11	force	force	NOUN
can-1683	84	12	between	between	ADP
can-1683	84	13	as	as	ADP
can-1683	84	14	plaque	plaque	NOUN
can-1683	84	15	and	and	CCONJ
can-1683	84	16	normal	normal	ADJ
can-1683	84	17	blood	blood	NOUN
can-1683	84	18	arteries	artery	NOUN
can-1683	84	19	may	may	AUX
can-1683	84	20	be	be	AUX
can-1683	84	21	used	use	VERB
can-1683	84	22	to	to	PART
can-1683	84	23	develop	develop	VERB
can-1683	84	24	blood	blood	NOUN
can-1683	84	25	fluid	fluid	ADJ
can-1683	84	26	shear	shear	NOUN
can-1683	84	27	-	-	PUNCT
can-1683	84	28	sensitive	sensitive	ADJ
can-1683	84	29	nanoparticles	nanoparticle	NOUN
can-1683	84	30	to	to	PART
can-1683	84	31	accomplish	accomplish	VERB
can-1683	84	32	physicochemical	physicochemical	ADJ
can-1683	84	33	targeting	targeting	NOUN
can-1683	84	34	.	.	PUNCT
can-1683	85	1	lipid	lipid	ADJ
can-1683	85	2	nanoparticles	nanoparticle	NOUN
can-1683	85	3	were	be	AUX
can-1683	85	4	formed	form	VERB
can-1683	85	5	into	into	ADP
can-1683	85	6	convex	convex	PROPN
can-1683	85	7	,	,	PUNCT
can-1683	85	8	two	two	NUM
can-1683	85	9	-	-	PUNCT
can-1683	85	10	sided	sided	ADJ
can-1683	85	11	lenticular	lenticular	ADJ
can-1683	85	12	nanoparticle	nanoparticle	NOUN
can-1683	85	13	vesicles	vesicle	NOUN
can-1683	85	14	,	,	PUNCT
can-1683	85	15	according	accord	VERB
can-1683	85	16	to	to	ADP
can-1683	85	17	holme	holme	PROPN
can-1683	85	18	et	et	PROPN
can-1683	85	19	al	al	PROPN
can-1683	85	20	.	.	PROPN
can-1683	86	1	as	as	SCONJ
can-1683	86	2	blood	blood	NOUN
can-1683	86	3	flow	flow	NOUN
can-1683	86	4	is	be	AUX
can-1683	86	5	increased	increase	VERB
can-1683	86	6	to	to	ADP
can-1683	86	7	the	the	DET
can-1683	86	8	as	as	ADP
can-1683	86	9	plaque	plaque	NOUN
can-1683	86	10	,	,	PUNCT
can-1683	86	11	the	the	DET
can-1683	86	12	drug	drug	NOUN
can-1683	86	13	-	-	PUNCT
can-1683	86	14	loaded	load	VERB
can-1683	86	15	nanoscale	nanoscale	NOUN
can-1683	86	16	is	be	AUX
can-1683	86	17	able	able	ADJ
can-1683	86	18	to	to	PART
can-1683	86	19	preserve	preserve	VERB
can-1683	86	20	its	its	PRON
can-1683	86	21	structural	structural	ADJ
can-1683	86	22	stability	stability	NOUN
can-1683	86	23	,	,	PUNCT
can-1683	86	24	and	and	CCONJ
can-1683	86	25	its	its	PRON
can-1683	86	26	configuration	configuration	NOUN
can-1683	86	27	change	change	NOUN
can-1683	86	28	may	may	AUX
can-1683	86	29	be	be	AUX
can-1683	86	30	leveraged	leverage	VERB
can-1683	86	31	to	to	PART
can-1683	86	32	release	release	VERB
can-1683	86	33	the	the	DET
can-1683	86	34	medication	medication	NOUN
can-1683	86	35	.	.	PUNCT
can-1683	87	1	it	it	PRON
can-1683	87	2	was	be	AUX
can-1683	87	3	based	base	VERB
can-1683	87	4	on	on	ADP
can-1683	87	5	platelet	platelet	NOUN
can-1683	87	6	activation	activation	NOUN
can-1683	87	7	and	and	CCONJ
can-1683	87	8	adherence	adherence	NOUN
can-1683	87	9	to	to	ADP
can-1683	87	10	plaque	plaque	NOUN
can-1683	87	11	blood	blood	NOUN
can-1683	87	12	vessels	vessel	NOUN
can-1683	87	13	in	in	ADP
can-1683	87	14	as	as	ADP
can-1683	87	15	plaques	plaque	NOUN
can-1683	87	16	that	that	PRON
can-1683	87	17	prompted	prompt	VERB
can-1683	87	18	the	the	DET
can-1683	87	19	development	development	NOUN
can-1683	87	20	of	of	ADP
can-1683	87	21	a	a	DET
can-1683	87	22	nanoparticle	nanoparticle	NOUN
can-1683	87	23	aggregate	aggregate	NOUN
can-1683	87	24	that	that	PRON
can-1683	87	25	may	may	AUX
can-1683	87	26	be	be	AUX
can-1683	87	27	built	build	VERB
can-1683	87	28	locally	locally	ADV
can-1683	87	29	in	in	ADP
can-1683	87	30	plaques[20	plaques[20	NOUN
can-1683	87	31	]	]	PUNCT
can-1683	87	32	.	.	PUNCT
can-1683	88	1	to	to	PART
can-1683	88	2	begin	begin	VERB
can-1683	88	3	,	,	PUNCT
can-1683	88	4	the	the	DET
can-1683	88	5	researchers	researcher	NOUN
can-1683	88	6	synthesized	synthesize	VERB
can-1683	88	7	plga	plga	NOUN
can-1683	88	8	nanoparticles	nanoparticle	NOUN
can-1683	88	9	with	with	ADP
can-1683	88	10	a	a	DET
can-1683	88	11	diameter	diameter	NOUN
can-1683	88	12	of	of	ADP
can-1683	88	13	180	180	NUM
can-1683	88	14	nm	nm	NOUN
can-1683	88	15	,	,	PUNCT
can-1683	88	16	encapsulated	encapsulate	VERB
can-1683	88	17	tissue	tissue	NOUN
can-1683	88	18	plasminogen	plasminogen	NOUN
can-1683	88	19	activator	activator	NOUN
can-1683	88	20	,	,	PUNCT
can-1683	88	21	and	and	CCONJ
can-1683	88	22	then	then	ADV
can-1683	88	23	used	use	VERB
can-1683	88	24	spray	spray	NOUN
can-1683	88	25	drying	dry	VERB
can-1683	88	26	to	to	PART
can-1683	88	27	produce	produce	VERB
can-1683	88	28	a	a	DET
can-1683	88	29	3.8	3.8	NUM
can-1683	88	30	nm	nm	ADJ
can-1683	88	31	plga	plga	NOUN
can-1683	88	32	nanoparticle	nanoparticle	NOUN
can-1683	88	33	aggregate	aggregate	NOUN
can-1683	88	34	.	.	PUNCT
can-1683	89	1	plga	plga	NOUN
can-1683	89	2	nanoparticles	nanoparticle	NOUN
can-1683	89	3	of	of	ADP
can-1683	89	4	180	180	NUM
can-1683	89	5	nm	nm	NOUN
can-1683	89	6	were	be	AUX
can-1683	89	7	formed	form	VERB
can-1683	89	8	after	after	ADP
can-1683	89	9	exposure	exposure	NOUN
can-1683	89	10	to	to	ADP
can-1683	89	11	the	the	DET
can-1683	89	12	high	high	ADJ
can-1683	89	13	fluid	fluid	ADJ
can-1683	89	14	shear	shear	NOUN
can-1683	89	15	stress	stress	NOUN
can-1683	89	16	of	of	ADP
can-1683	89	17	the	the	DET
can-1683	89	18	as	as	ADP
can-1683	89	19	plaque	plaque	NOUN
can-1683	89	20	,	,	PUNCT
can-1683	89	21	and	and	CCONJ
can-1683	89	22	these	these	DET
can-1683	89	23	nanoparticles	nanoparticle	NOUN
can-1683	89	24	were	be	AUX
can-1683	89	25	then	then	ADV
can-1683	89	26	able	able	ADJ
can-1683	89	27	to	to	PART
can-1683	89	28	penetrate	penetrate	VERB
can-1683	89	29	the	the	DET
can-1683	89	30	plaque	plaque	NOUN
can-1683	89	31	’s	’s	PART
can-1683	89	32	local	local	ADJ
can-1683	89	33	thrombus	thrombus	NOUN
can-1683	89	34	because	because	SCONJ
can-1683	89	35	of	of	ADP
can-1683	89	36	the	the	DET
can-1683	89	37	nanoparticles	nanoparticle	NOUN
can-1683	89	38	’	'	PUNCT
can-1683	89	39	great	great	ADJ
can-1683	89	40	penetrability	penetrability	NOUN
can-1683	89	41	.	.	PUNCT
can-1683	90	1	the	the	DET
can-1683	90	2	thrombolytic	thrombolytic	ADJ
can-1683	90	3	impact	impact	NOUN
can-1683	90	4	increased	increase	VERB
can-1683	90	5	effectiveness	effectiveness	NOUN
can-1683	90	6	while	while	SCONJ
can-1683	90	7	minimizing	minimize	VERB
can-1683	90	8	thrombolysis	thrombolysis	ADV
can-1683	90	9	’	'	PUNCT
can-1683	90	10	negative	negative	ADJ
can-1683	90	11	effects	effect	NOUN
can-1683	90	12	and	and	CCONJ
can-1683	90	13	dosage	dosage	NOUN
can-1683	90	14	requirements	requirement	NOUN
can-1683	90	15	.	.	PUNCT
can-1683	91	1	cardiomyopathy	cardiomyopathy	ADJ
can-1683	91	2	is	be	AUX
can-1683	91	3	characterized	characterize	VERB
can-1683	91	4	by	by	ADP
can-1683	91	5	an	an	DET
can-1683	91	6	endothelial	endothelial	ADJ
can-1683	91	7	gap	gap	NOUN
can-1683	91	8	that	that	PRON
can-1683	91	9	widens	widen	VERB
can-1683	91	10	and	and	CCONJ
can-1683	91	11	polysaccharide	polysaccharide	NOUN
can-1683	91	12	from	from	ADP
can-1683	91	13	ophiopogon	ophiopogon	NOUN
can-1683	91	14	japonicus	japonicus	NOUN
can-1683	91	15	polysaccharides	polysaccharide	NOUN
can-1683	91	16	in	in	ADP
can-1683	91	17	ischemic	ischemic	ADJ
can-1683	91	18	myocardium	myocardium	NOUN
can-1683	91	19	that	that	PRON
can-1683	91	20	is	be	AUX
can-1683	91	21	twice	twice	ADV
can-1683	91	22	as	as	ADV
can-1683	91	23	high	high	ADJ
can-1683	91	24	as	as	ADP
can-1683	91	25	that	that	PRON
can-1683	91	26	of	of	ADP
can-1683	91	27	normal	normal	ADJ
can-1683	91	28	rats	rat	NOUN
can-1683	91	29	.	.	PUNCT
can-1683	92	1	both	both	DET
can-1683	92	2	shear	shear	VERB
can-1683	92	3	stress	stress	NOUN
can-1683	92	4	and	and	CCONJ
can-1683	92	5	blood	blood	NOUN
can-1683	92	6	flow	flow	NOUN
can-1683	92	7	shear	shear	NOUN
can-1683	92	8	rate	rate	NOUN
can-1683	92	9	of	of	ADP
can-1683	92	10	the	the	DET
can-1683	92	11	vascular	vascular	ADJ
can-1683	92	12	wall	wall	NOUN
can-1683	92	13	can	can	AUX
can-1683	92	14	influence	influence	VERB
can-1683	92	15	the	the	DET
can-1683	92	16	aggregation	aggregation	NOUN
can-1683	92	17	of	of	ADP
can-1683	92	18	nanoparticles	nanoparticle	NOUN
can-1683	92	19	,	,	PUNCT
can-1683	92	20	according	accord	VERB
can-1683	92	21	to	to	ADP
can-1683	92	22	tan	tan	PROPN
can-1683	92	23	et	et	PROPN
can-1683	92	24	al.[21	al.[21	PROPN
can-1683	92	25	]	]	PUNCT
can-1683	92	26	.	.	PUNCT
can-1683	93	1	3.3	3.3	NUM
can-1683	93	2	magnetically	magnetically	ADV
can-1683	93	3	guided	guide	VERB
can-1683	93	4	a	a	DET
can-1683	93	5	“	"	PUNCT
can-1683	93	6	pseudo	pseudo	NOUN
can-1683	93	7	-	-	ADJ
can-1683	93	8	passive	passive	ADJ
can-1683	93	9	”	"	PUNCT
can-1683	93	10	targeting	target	VERB
can-1683	93	11	approach	approach	NOUN
can-1683	93	12	using	use	VERB
can-1683	93	13	a	a	DET
can-1683	93	14	magnetically	magnetically	ADV
can-1683	93	15	guided	guide	VERB
can-1683	93	16	nanoparticle	nanoparticle	NOUN
can-1683	93	17	seems	seem	VERB
can-1683	93	18	intriguing	intriguing	ADJ
can-1683	93	19	.	.	PUNCT
can-1683	94	1	in	in	ADP
can-1683	94	2	theory	theory	NOUN
can-1683	94	3	,	,	PUNCT
can-1683	94	4	magnetic	magnetic	ADJ
can-1683	94	5	nanoparticles	nanoparticle	NOUN
can-1683	94	6	may	may	AUX
can-1683	94	7	be	be	AUX
can-1683	94	8	directed	direct	VERB
can-1683	94	9	to	to	ADP
can-1683	94	10	the	the	DET
can-1683	94	11	illness	illness	NOUN
can-1683	94	12	location	location	NOUN
can-1683	94	13	by	by	ADP
can-1683	94	14	the	the	DET
can-1683	94	15	application	application	NOUN
can-1683	94	16	of	of	ADP
can-1683	94	17	an	an	DET
can-1683	94	18	external	external	ADJ
can-1683	94	19	magnetic	magnetic	ADJ
can-1683	94	20	field	field	NOUN
can-1683	94	21	.	.	PUNCT
can-1683	95	1	cvd	cvd	PROPN
can-1683	95	2	patients	patient	NOUN
can-1683	95	3	may	may	AUX
can-1683	95	4	benefit	benefit	VERB
can-1683	95	5	from	from	ADP
can-1683	95	6	this	this	DET
can-1683	95	7	approach	approach	NOUN
can-1683	95	8	,	,	PUNCT
can-1683	95	9	as	as	SCONJ
can-1683	95	10	evidenced	evidence	VERB
can-1683	95	11	by	by	ADP
can-1683	95	12	recent	recent	ADJ
can-1683	95	13	studies	study	NOUN
can-1683	95	14	.	.	PUNCT
can-1683	96	1	the	the	DET
can-1683	96	2	effects	effect	NOUN
can-1683	96	3	of	of	ADP
can-1683	96	4	several	several	ADJ
can-1683	96	5	nano	nano	NOUN
can-1683	96	6	drug	drug	NOUN
can-1683	96	7	carriers	carrier	NOUN
can-1683	96	8	on	on	ADP
can-1683	96	9	atherosclerotic	atherosclerotic	ADJ
can-1683	96	10	plaque	plaque	NOUN
can-1683	96	11	imaging	imaging	NOUN
can-1683	96	12	were	be	AUX
can-1683	96	13	examined[22	examined[22	NOUN
can-1683	96	14	]	]	PUNCT
can-1683	96	15	.	.	PUNCT
can-1683	97	1	ultra	ultra	ADJ
can-1683	97	2	-	-	ADJ
can-1683	97	3	tiny	tiny	ADJ
can-1683	97	4	,	,	PUNCT
can-1683	97	5	superparamagnetic	superparamagnetic	ADJ
can-1683	97	6	iron	iron	NOUN
can-1683	97	7	oxide	oxide	NOUN
can-1683	97	8	nano	nano	NOUN
can-1683	97	9	-	-	PUNCT
can-1683	97	10	carriers	carrier	NOUN
can-1683	97	11	,	,	PUNCT
can-1683	97	12	and	and	CCONJ
can-1683	97	13	extremely	extremely	ADV
can-1683	97	14	small	small	ADJ
can-1683	97	15	superparamagnetic	superparamagnetic	ADJ
can-1683	97	16	iron	iron	NOUN
can-1683	97	17	oxide	oxide	NOUN
can-1683	97	18	nanoparticles	nanoparticle	NOUN
can-1683	97	19	are	be	AUX
can-1683	97	20	some	some	PRON
can-1683	97	21	of	of	ADP
can-1683	97	22	the	the	DET
can-1683	97	23	nanoparticle	nanoparticle	NOUN
can-1683	97	24	forms	form	NOUN
can-1683	97	25	of	of	ADP
can-1683	97	26	iron	iron	NOUN
can-1683	97	27	oxide	oxide	NOUN
can-1683	97	28	.	.	PUNCT
can-1683	98	1	one	one	NUM
can-1683	98	2	collection	collection	NOUN
can-1683	98	3	of	of	ADP
can-1683	98	4	ultra	ultra	ADJ
can-1683	98	5	-	-	ADJ
can-1683	98	6	small	small	ADJ
can-1683	98	7	superparamagnetic	superparamagnetic	ADJ
can-1683	98	8	iron	iron	NOUN
can-1683	98	9	oxide	oxide	NOUN
can-1683	98	10	nanoparticles	nanoparticle	NOUN
can-1683	98	11	performed	perform	VERB
can-1683	98	12	significantly	significantly	ADV
can-1683	98	13	better	well	ADJ
can-1683	98	14	than	than	ADP
can-1683	98	15	others	other	NOUN
can-1683	98	16	in	in	ADP
can-1683	98	17	terms	term	NOUN
can-1683	98	18	of	of	ADP
can-1683	98	19	vascular	vascular	ADJ
can-1683	98	20	wall	wall	NOUN
can-1683	98	21	penetration	penetration	NOUN
can-1683	98	22	and	and	CCONJ
can-1683	98	23	plaque	plaque	NOUN
can-1683	98	24	retention	retention	NOUN
can-1683	98	25	.	.	PUNCT
can-1683	99	1	external	external	ADJ
can-1683	99	2	magnetic	magnetic	ADJ
can-1683	99	3	fields	field	NOUN
can-1683	99	4	may	may	AUX
can-1683	99	5	aid	aid	VERB
can-1683	99	6	in	in	ADP
can-1683	99	7	the	the	DET
can-1683	99	8	movement	movement	NOUN
can-1683	99	9	of	of	ADP
can-1683	99	10	particles	particle	NOUN
can-1683	99	11	from	from	ADP
can-1683	99	12	the	the	DET
can-1683	99	13	cell	cell	NOUN
can-1683	99	14	-	-	PUNCT
can-1683	99	15	free	free	ADJ
can-1683	99	16	layer	layer	NOUN
can-1683	99	17	,	,	PUNCT
can-1683	99	18	which	which	PRON
can-1683	99	19	lacks	lack	VERB
can-1683	99	20	red	red	ADJ
can-1683	99	21	blood	blood	NOUN
can-1683	99	22	cells	cell	NOUN
can-1683	99	23	,	,	PUNCT
can-1683	99	24	to	to	ADP
can-1683	99	25	the	the	DET
can-1683	99	26	artery	artery	NOUN
can-1683	99	27	wall	wall	NOUN
can-1683	99	28	,	,	PUNCT
can-1683	99	29	some	some	DET
can-1683	99	30	studies	study	NOUN
can-1683	99	31	have	have	VERB
can-1683	99	32	suggested[23	suggested[23	ADJ
can-1683	99	33	]	]	PUNCT
can-1683	99	34	.	.	PUNCT
can-1683	100	1	figure	figure	NOUN
can-1683	100	2	1	1	NUM
can-1683	100	3	illustrates	illustrate	VERB
can-1683	100	4	the	the	DET
can-1683	100	5	passive	passive	ADJ
can-1683	100	6	and	and	CCONJ
can-1683	100	7	active	active	ADJ
can-1683	100	8	targeting	targeting	NOUN
can-1683	100	9	strategy	strategy	NOUN
can-1683	100	10	.	.	PUNCT
can-1683	101	1	13	13	NUM
can-1683	101	2	figure	figure	NOUN
can-1683	101	3	1	1	NUM
can-1683	101	4	.	.	PUNCT
can-1683	101	5	drug	drug	NOUN
can-1683	101	6	targeting	targeting	NOUN
can-1683	101	7	strategy	strategy	NOUN
can-1683	101	8	.	.	PUNCT
can-1683	102	1	(	(	PUNCT
can-1683	102	2	a	a	X
can-1683	102	3	)	)	PUNCT
can-1683	102	4	passive	passive	ADJ
can-1683	102	5	targeting	targeting	NOUN
can-1683	102	6	(	(	PUNCT
can-1683	102	7	b	b	NOUN
can-1683	102	8	)	)	PUNCT
can-1683	102	9	active	active	ADJ
can-1683	102	10	targeting	targeting	NOUN
can-1683	102	11	.	.	PUNCT
can-1683	103	1	3.4	3.4	NUM
can-1683	103	2	active	active	ADJ
can-1683	103	3	targeted	target	VERB
can-1683	103	4	transhipment	transhipment	NOUN
can-1683	103	5	passive	passive	ADJ
can-1683	103	6	targeting	targeting	NOUN
can-1683	103	7	may	may	AUX
can-1683	103	8	be	be	AUX
can-1683	103	9	utilized	utilize	VERB
can-1683	103	10	to	to	PART
can-1683	103	11	build	build	VERB
can-1683	103	12	an	an	DET
can-1683	103	13	active	active	ADJ
can-1683	103	14	targeting	targeting	NOUN
can-1683	103	15	approach	approach	NOUN
can-1683	103	16	for	for	ADP
can-1683	103	17	cvds	cvds	PROPN
can-1683	103	18	based	base	VERB
can-1683	103	19	on	on	ADP
can-1683	103	20	their	their	PRON
can-1683	103	21	unique	unique	ADJ
can-1683	103	22	pathological	pathological	ADJ
can-1683	103	23	characteristics	characteristic	NOUN
can-1683	103	24	,	,	PUNCT
can-1683	103	25	which	which	PRON
can-1683	103	26	has	have	AUX
can-1683	103	27	piqued	pique	VERB
can-1683	103	28	the	the	DET
can-1683	103	29	interest	interest	NOUN
can-1683	103	30	of	of	ADP
can-1683	103	31	researchers	researcher	NOUN
can-1683	103	32	interested	interested	ADJ
can-1683	103	33	in	in	ADP
can-1683	103	34	improving	improve	VERB
can-1683	103	35	the	the	DET
can-1683	103	36	targeted	target	VERB
can-1683	103	37	delivery	delivery	NOUN
can-1683	103	38	efficiency	efficiency	NOUN
can-1683	103	39	of	of	ADP
can-1683	103	40	medications	medication	NOUN
can-1683	103	41	to	to	ADP
can-1683	103	42	cvd	cvd	PROPN
can-1683	103	43	lesions	lesion	NOUN
can-1683	103	44	.	.	PUNCT
can-1683	104	1	nddss	nddss	NOUN
can-1683	104	2	with	with	ADP
can-1683	104	3	one	one	NUM
can-1683	104	4	or	or	CCONJ
can-1683	104	5	more	more	ADJ
can-1683	104	6	targets	target	NOUN
can-1683	104	7	are	be	AUX
can-1683	104	8	the	the	DET
can-1683	104	9	primary	primary	ADJ
can-1683	104	10	focus	focus	NOUN
can-1683	104	11	of	of	ADP
can-1683	104	12	active	active	ADJ
can-1683	104	13	targeting	target	VERB
can-1683	104	14	in	in	ADP
can-1683	104	15	order	order	NOUN
can-1683	104	16	to	to	PART
can-1683	104	17	facilitate	facilitate	VERB
can-1683	104	18	medication	medication	NOUN
can-1683	104	19	delivery	delivery	NOUN
can-1683	104	20	to	to	ADP
can-1683	104	21	a	a	DET
can-1683	104	22	specific	specific	ADJ
can-1683	104	23	location[24	location[24	NOUN
can-1683	104	24	]	]	PUNCT
can-1683	104	25	.	.	PUNCT
can-1683	105	1	in	in	ADP
can-1683	105	2	other	other	ADJ
can-1683	105	3	words	word	NOUN
can-1683	105	4	,	,	PUNCT
can-1683	105	5	the	the	DET
can-1683	105	6	ability	ability	NOUN
can-1683	105	7	of	of	ADP
can-1683	105	8	carriers	carrier	NOUN
can-1683	105	9	to	to	PART
can-1683	105	10	target	target	VERB
can-1683	105	11	sick	sick	ADJ
can-1683	105	12	tissues	tissue	NOUN
can-1683	105	13	or	or	CCONJ
can-1683	105	14	cells	cell	NOUN
can-1683	105	15	will	will	AUX
can-1683	105	16	be	be	AUX
can-1683	105	17	improved	improve	VERB
can-1683	105	18	by	by	ADP
can-1683	105	19	adding	add	VERB
can-1683	105	20	a	a	DET
can-1683	105	21	functional	functional	ADJ
can-1683	105	22	group	group	NOUN
can-1683	105	23	or	or	CCONJ
can-1683	105	24	active	active	ADJ
can-1683	105	25	material	material	NOUN
can-1683	105	26	to	to	ADP
can-1683	105	27	the	the	DET
can-1683	105	28	surface	surface	NOUN
can-1683	105	29	of	of	ADP
can-1683	105	30	the	the	DET
can-1683	105	31	nano	nano	NOUN
can-1683	105	32	-	-	PUNCT
can-1683	105	33	drug	drug	NOUN
can-1683	105	34	carrier	carrier	NOUN
can-1683	105	35	.	.	PUNCT
can-1683	106	1	3.4.1	3.4.1	NUM
can-1683	106	2	active	active	ADJ
can-1683	106	3	targeting	targeting	NOUN
can-1683	106	4	of	of	ADP
can-1683	106	5	vascular	vascular	ADJ
can-1683	106	6	endothelial	endothelial	NOUN
can-1683	106	7	cells	cell	NOUN
can-1683	106	8	the	the	DET
can-1683	106	9	vascular	vascular	ADJ
can-1683	106	10	endothelial	endothelial	NOUN
can-1683	106	11	cells	cell	NOUN
can-1683	106	12	of	of	ADP
can-1683	106	13	cvds	cvds	PROPN
can-1683	106	14	are	be	AUX
can-1683	106	15	in	in	ADP
can-1683	106	16	an	an	DET
can-1683	106	17	inflammatory	inflammatory	ADJ
can-1683	106	18	activation	activation	NOUN
can-1683	106	19	state	state	NOUN
can-1683	106	20	at	at	ADP
can-1683	106	21	different	different	ADJ
can-1683	106	22	phases	phase	NOUN
can-1683	106	23	of	of	ADP
can-1683	106	24	the	the	DET
can-1683	106	25	disease	disease	NOUN
can-1683	106	26	.	.	PUNCT
can-1683	107	1	one	one	NUM
can-1683	107	2	of	of	ADP
can-1683	107	3	the	the	DET
can-1683	107	4	main	main	ADJ
can-1683	107	5	targets	target	NOUN
can-1683	107	6	for	for	ADP
can-1683	107	7	nddss	nddss	NOUN
can-1683	107	8	is	be	AUX
can-1683	107	9	the	the	DET
can-1683	107	10	overexpression	overexpression	NOUN
can-1683	107	11	of	of	ADP
can-1683	107	12	certain	certain	ADJ
can-1683	107	13	small	small	ADJ
can-1683	107	14	molecules	molecule	NOUN
can-1683	107	15	in	in	ADP
can-1683	107	16	these	these	DET
can-1683	107	17	cancerous	cancerous	ADJ
can-1683	107	18	endothelial	endothelial	ADJ
can-1683	107	19	cells	cell	NOUN
can-1683	107	20	,	,	PUNCT
can-1683	107	21	such	such	ADJ
can-1683	107	22	as	as	ADP
can-1683	107	23	icam-1	icam-1	NUM
can-1683	107	24	and	and	CCONJ
can-1683	107	25	vcam-1	vcam-1	NUM
can-1683	107	26	.	.	PUNCT
can-1683	107	27	other	other	ADJ
can-1683	107	28	small	small	ADJ
can-1683	107	29	molecules	molecule	NOUN
can-1683	107	30	that	that	PRON
can-1683	107	31	are	be	AUX
can-1683	107	32	overexpressed	overexpresse	VERB
can-1683	107	33	include	include	VERB
can-1683	107	34	integrins	integrin	NOUN
can-1683	107	35	and	and	CCONJ
can-1683	107	36	selectins[25	selectins[25	NOUN
can-1683	107	37	]	]	X
can-1683	107	38	.	.	PUNCT
can-1683	108	1	liposomal	liposomal	ADJ
can-1683	108	2	delivery	delivery	NOUN
can-1683	108	3	of	of	ADP
can-1683	108	4	anti	anti	ADJ
can-1683	108	5	-	-	ADJ
can-1683	108	6	inflammatory	inflammatory	ADJ
can-1683	108	7	liposomes	liposome	NOUN
can-1683	108	8	to	to	ADP
can-1683	108	9	the	the	DET
can-1683	108	10	pulmonary	pulmonary	ADJ
can-1683	108	11	vascular	vascular	NOUN
can-1683	108	12	system	system	NOUN
can-1683	108	13	is	be	AUX
can-1683	108	14	improved	improve	VERB
can-1683	108	15	by	by	ADP
can-1683	108	16	conjugating	conjugate	VERB
can-1683	108	17	lung	lung	NOUN
can-1683	108	18	-	-	PUNCT
can-1683	108	19	specific	specific	ADJ
can-1683	108	20	single	single	ADJ
can-1683	108	21	-	-	PUNCT
can-1683	108	22	stranded	strand	VERB
can-1683	108	23	variable	variable	ADJ
can-1683	108	24	fragment	fragment	NOUN
can-1683	108	25	/	/	SYM
can-1683	108	26	liposome	liposome	NOUN
can-1683	108	27	with	with	ADP
can-1683	108	28	pecam-1	pecam-1	PROPN
can-1683	108	29	(	(	PUNCT
can-1683	108	30	platelet	platelet	NOUN
can-1683	108	31	endothelial	endothelial	ADJ
can-1683	108	32	cell	cell	NOUN
can-1683	108	33	adhesion	adhesion	NOUN
can-1683	108	34	molecule	molecule	NOUN
can-1683	108	35	1	1	NUM
can-1683	108	36	)	)	PUNCT
can-1683	108	37	antibody[26	antibody[26	PROPN
can-1683	108	38	]	]	PUNCT
can-1683	108	39	.	.	PUNCT
can-1683	109	1	anti	anti	ADJ
can-1683	109	2	-	-	ADJ
can-1683	109	3	vcam-1	vcam-1	ADJ
can-1683	109	4	monoclonal	monoclonal	NOUN
can-1683	109	5	antibody	antibody	NOUN
can-1683	109	6	was	be	AUX
can-1683	109	7	used	use	VERB
can-1683	109	8	to	to	PART
can-1683	109	9	silica	silica	VERB
can-1683	109	10	nanoparticles	nanoparticle	NOUN
can-1683	109	11	in	in	ADP
can-1683	109	12	2013	2013	NUM
can-1683	109	13	.	.	PUNCT
can-1683	110	1	before	before	ADP
can-1683	110	2	being	be	AUX
can-1683	110	3	absorbed	absorb	VERB
can-1683	110	4	by	by	ADP
can-1683	110	5	endothelial	endothelial	ADJ
can-1683	110	6	cells	cell	NOUN
can-1683	110	7	,	,	PUNCT
can-1683	110	8	the	the	DET
can-1683	110	9	nanoparticles	nanoparticle	NOUN
can-1683	110	10	were	be	AUX
can-1683	110	11	able	able	ADJ
can-1683	110	12	to	to	PART
can-1683	110	13	attach	attach	VERB
can-1683	110	14	to	to	ADP
can-1683	110	15	inflammatory	inflammatory	ADJ
can-1683	110	16	sites	site	NOUN
can-1683	110	17	.	.	PUNCT
can-1683	111	1	the	the	DET
can-1683	111	2	antibody	antibody	NOUN
can-1683	111	3	anti	anti	NOUN
can-1683	111	4	-	-	ADJ
can-1683	111	5	icam-1	icam-1	NOUN
can-1683	111	6	,	,	PUNCT
can-1683	111	7	which	which	PRON
can-1683	111	8	actively	actively	ADV
can-1683	111	9	targets	target	VERB
can-1683	111	10	icam-1	icam-1	NUM
can-1683	111	11	on	on	ADP
can-1683	111	12	the	the	DET
can-1683	111	13	liposome	liposome	NOUN
can-1683	111	14	surface	surface	NOUN
can-1683	111	15	and	and	CCONJ
can-1683	111	16	loads	load	VERB
can-1683	111	17	contrast	contrast	VERB
can-1683	111	18	chemicals[27	chemicals[27	PROPN
can-1683	111	19	]	]	PUNCT
can-1683	111	20	based	base	VERB
can-1683	111	21	on	on	ADP
can-1683	111	22	the	the	DET
can-1683	111	23	pathological	pathological	ADJ
can-1683	111	24	characteristics	characteristic	NOUN
can-1683	111	25	of	of	ADP
can-1683	111	26	elevated	elevated	ADJ
can-1683	111	27	icam-1	icam-1	NUM
can-1683	111	28	expression	expression	NOUN
can-1683	111	29	in	in	ADP
can-1683	111	30	early	early	ADJ
can-1683	111	31	vascular	vascular	ADJ
can-1683	111	32	endothelial	endothelial	NOUN
can-1683	111	33	cells	cell	NOUN
can-1683	111	34	of	of	ADP
can-1683	111	35	as	as	ADP
can-1683	111	36	(	(	PUNCT
can-1683	111	37	gadolinium	gadolinium	NOUN
can-1683	111	38	)	)	PUNCT
can-1683	111	39	.	.	PUNCT
can-1683	112	1	anti	anti	PROPN
can-1683	112	2	-	-	ADJ
can-1683	112	3	icam-1	icam-1	NUM
can-1683	112	4	and	and	CCONJ
can-1683	112	5	icam-1	icam-1	NUM
can-1683	112	6	have	have	AUX
can-1683	112	7	been	be	AUX
can-1683	112	8	proven	prove	VERB
can-1683	112	9	in	in	ADP
can-1683	112	10	studies	study	NOUN
can-1683	112	11	to	to	PART
can-1683	112	12	have	have	VERB
can-1683	112	13	a	a	DET
can-1683	112	14	particular	particular	ADJ
can-1683	112	15	effect	effect	NOUN
can-1683	112	16	on	on	ADP
can-1683	112	17	liposomes	liposome	NOUN
can-1683	112	18	that	that	PRON
can-1683	112	19	activates	activate	VERB
can-1683	112	20	the	the	DET
can-1683	112	21	targeting	targeting	NOUN
can-1683	112	22	of	of	ADP
can-1683	112	23	vascular	vascular	ADJ
can-1683	112	24	endothelial	endothelial	ADJ
can-1683	112	25	cells	cell	NOUN
can-1683	112	26	and	and	CCONJ
can-1683	112	27	as	as	ADP
can-1683	112	28	plaques	plaque	NOUN
can-1683	112	29	.	.	PUNCT
can-1683	113	1	liposomes	liposome	NOUN
can-1683	113	2	’	'	PUNCT
can-1683	113	3	ability	ability	NOUN
can-1683	113	4	to	to	PART
can-1683	113	5	target	target	VERB
can-1683	113	6	as	as	SCONJ
can-1683	113	7	plaques	plaque	NOUN
can-1683	113	8	may	may	AUX
can-1683	113	9	be	be	AUX
can-1683	113	10	compromised	compromise	VERB
can-1683	113	11	if	if	SCONJ
can-1683	113	12	circulating	circulate	VERB
can-1683	113	13	white	white	ADJ
can-1683	113	14	blood	blood	NOUN
can-1683	113	15	cells	cell	NOUN
can-1683	113	16	compete	compete	VERB
can-1683	113	17	for	for	ADP
can-1683	113	18	binding	bind	VERB
can-1683	113	19	to	to	ADP
can-1683	113	20	the	the	DET
can-1683	113	21	icam-1	icam-1	NUM
can-1683	113	22	site	site	NOUN
can-1683	113	23	and	and	CCONJ
can-1683	113	24	blood	blood	NOUN
can-1683	113	25	flow	flow	NOUN
can-1683	113	26	shearing	shearing	NOUN
can-1683	113	27	occurs	occur	VERB
can-1683	113	28	.	.	PUNCT
can-1683	114	1	liposome	liposome	VERB
can-1683	114	2	binding	bind	VERB
can-1683	114	3	to	to	ADP
can-1683	114	4	icam-1	icam-1	NUM
can-1683	114	5	was	be	AUX
can-1683	114	6	improved	improve	VERB
can-1683	114	7	by	by	ADP
can-1683	114	8	testing	test	VERB
can-1683	114	9	liposome	liposome	NOUN
can-1683	114	10	particle	particle	NOUN
can-1683	114	11	size	size	NOUN
can-1683	114	12	,	,	PUNCT
can-1683	114	13	antibody	antibody	NOUN
can-1683	114	14	concentration	concentration	NOUN
can-1683	114	15	,	,	PUNCT
can-1683	114	16	and	and	CCONJ
can-1683	114	17	lipid	lipid	NOUN
can-1683	114	18	concentration	concentration	NOUN
can-1683	114	19	ratios	ratio	NOUN
can-1683	114	20	.	.	PUNCT
can-1683	115	1	as	as	ADP
can-1683	115	2	an	an	DET
can-1683	115	3	endothelial	endothelial	ADJ
can-1683	115	4	cell	cell	NOUN
can-1683	115	5	glycoprotein	glycoprotein	NOUN
can-1683	115	6	,	,	PUNCT
can-1683	115	7	e	e	NOUN
can-1683	115	8	-	-	NOUN
can-1683	115	9	selectin	selectin	NOUN
can-1683	115	10	promotes	promote	VERB
can-1683	115	11	the	the	DET
can-1683	115	12	attachment	attachment	NOUN
can-1683	115	13	of	of	ADP
can-1683	115	14	monocytes	monocyte	NOUN
can-1683	115	15	/	/	SYM
can-1683	115	16	macrophages	macrophage	NOUN
can-1683	115	17	and	and	CCONJ
can-1683	115	18	lymphocytes	lymphocyte	VERB
can-1683	115	19	to	to	PART
can-1683	115	20	trigger	trigger	VERB
can-1683	115	21	an	an	DET
can-1683	115	22	inflammatory	inflammatory	ADJ
can-1683	115	23	response	response	NOUN
can-1683	115	24	,	,	PUNCT
can-1683	115	25	ultimately	ultimately	ADV
can-1683	115	26	leading	lead	VERB
can-1683	115	27	to	to	ADP
can-1683	115	28	cvds	cvds	NOUN
can-1683	115	29	such	such	ADJ
can-1683	115	30	as	as	ADP
can-1683	115	31	(	(	PUNCT
can-1683	115	32	atherosclerosis	atherosclerosis	NOUN
can-1683	115	33	-	-	PUNCT
can-1683	115	34	related	relate	VERB
can-1683	115	35	cardiovascular	cardiovascular	ADJ
can-1683	115	36	disease)[28	disease)[28	PROPN
can-1683	115	37	]	]	PUNCT
can-1683	115	38	.	.	PUNCT
can-1683	116	1	also	also	ADV
can-1683	116	2	,	,	PUNCT
can-1683	116	3	nano	nano	NOUN
can-1683	116	4	-	-	PUNCT
can-1683	116	5	transport	transport	NOUN
can-1683	116	6	medicines	medicine	NOUN
can-1683	116	7	might	might	AUX
can-1683	116	8	leverage	leverage	VERB
can-1683	116	9	the	the	DET
can-1683	116	10	target	target	NOUN
can-1683	116	11	of	of	ADP
can-1683	116	12	e	e	NOUN
can-1683	116	13	-	-	NOUN
can-1683	116	14	selectin	selectin	NOUN
can-1683	116	15	.	.	PUNCT
can-1683	117	1	human	human	ADJ
can-1683	117	2	umbilical	umbilical	ADJ
can-1683	117	3	vein	vein	ADJ
can-1683	117	4	endothelial	endothelial	NOUN
can-1683	117	5	cells	cell	NOUN
can-1683	117	6	triggered	trigger	VERB
can-1683	117	7	by	by	ADP
can-1683	117	8	interleukin-1	interleukin-1	NOUN
can-1683	117	9	(	(	PUNCT
can-1683	117	10	il-1	il-1	NUM
can-1683	117	11	)	)	PUNCT
can-1683	117	12	and	and	CCONJ
can-1683	117	13	umbilical	umbilical	ADJ
can-1683	117	14	cord	cord	NOUN
can-1683	117	15	vein	vein	VERB
can-1683	117	16	endothelial	endothelial	ADJ
can-1683	117	17	cells	cell	NOUN
can-1683	117	18	not	not	PART
can-1683	117	19	14	14	NUM
can-1683	117	20	stimulated	stimulate	VERB
can-1683	117	21	by	by	ADP
can-1683	117	22	il-1	il-1	X
can-1683	117	23	(	(	PUNCT
can-1683	117	24	il-1	il-1	NUM
can-1683	117	25	)	)	PUNCT
can-1683	117	26	were	be	AUX
can-1683	117	27	treated	treat	VERB
can-1683	117	28	with	with	ADP
can-1683	117	29	functional	functional	ADJ
can-1683	117	30	liposomes	liposome	NOUN
can-1683	117	31	containing	contain	VERB
can-1683	117	32	mouse	mouse	NOUN
can-1683	117	33	h18/7	h18/7	X
can-1683	117	34	mab	mab	NOUN
can-1683	117	35	(	(	PUNCT
can-1683	117	36	an	an	DET
can-1683	117	37	e	e	NOUN
can-1683	117	38	-	-	ADJ
can-1683	117	39	selectin	selectin	ADJ
can-1683	117	40	-	-	PUNCT
can-1683	117	41	specific	specific	ADJ
can-1683	117	42	antibody	antibody	NOUN
can-1683	117	43	)	)	PUNCT
can-1683	117	44	.	.	PUNCT
can-1683	118	1	the	the	DET
can-1683	118	2	capacity	capacity	NOUN
can-1683	118	3	of	of	ADP
can-1683	118	4	functional	functional	ADJ
can-1683	118	5	liposomes	liposome	NOUN
can-1683	118	6	to	to	PART
can-1683	118	7	target	target	VERB
can-1683	118	8	activated	activate	VERB
can-1683	118	9	human	human	ADJ
can-1683	118	10	umbilical	umbilical	ADJ
can-1683	118	11	vein	vein	ADJ
can-1683	118	12	endothelial	endothelial	NOUN
can-1683	118	13	cells	cell	NOUN
can-1683	118	14	was	be	AUX
can-1683	118	15	shown	show	VERB
can-1683	118	16	to	to	PART
can-1683	118	17	be	be	AUX
can-1683	118	18	275	275	NUM
can-1683	118	19	times	time	NOUN
can-1683	118	20	more	more	ADJ
can-1683	118	21	than	than	ADP
can-1683	118	22	that	that	PRON
can-1683	118	23	of	of	ADP
can-1683	118	24	the	the	DET
can-1683	118	25	non	non	ADJ
can-1683	118	26	-	-	ADJ
can-1683	118	27	activated	activated	ADJ
can-1683	118	28	form	form	NOUN
can-1683	118	29	of	of	ADP
can-1683	118	30	liposomes[29	liposomes[29	NOUN
can-1683	118	31	]	]	PUNCT
can-1683	118	32	.	.	PUNCT
can-1683	119	1	when	when	SCONJ
can-1683	119	2	a	a	DET
can-1683	119	3	myocardial	myocardial	ADJ
can-1683	119	4	infarction	infarction	NOUN
can-1683	119	5	or	or	CCONJ
can-1683	119	6	heart	heart	NOUN
can-1683	119	7	failure	failure	NOUN
can-1683	119	8	occurs	occur	VERB
can-1683	119	9	,	,	PUNCT
can-1683	119	10	at1	at1	PROPN
can-1683	119	11	levels	level	NOUN
can-1683	119	12	increase	increase	VERB
can-1683	119	13	in	in	ADP
can-1683	119	14	myocardial	myocardial	ADJ
can-1683	119	15	tissue	tissue	NOUN
can-1683	119	16	.	.	PUNCT
can-1683	120	1	polyethylene	polyethylene	NOUN
can-1683	120	2	glycol	glycol	NOUN
can-1683	120	3	liposomes	liposome	NOUN
can-1683	120	4	(	(	PUNCT
can-1683	120	5	1,428	1,428	NUM
can-1683	120	6	nm	nm	NOUN
can-1683	120	7	)	)	PUNCT
can-1683	120	8	were	be	AUX
can-1683	120	9	developed[30	developed[30	NOUN
can-1683	120	10	]	]	PUNCT
can-1683	120	11	to	to	PART
can-1683	120	12	deliver	deliver	VERB
can-1683	120	13	medicinal	medicinal	ADJ
can-1683	120	14	payloads	payload	NOUN
can-1683	120	15	(	(	PUNCT
can-1683	120	16	such	such	ADJ
can-1683	120	17	as	as	ADP
can-1683	120	18	growth	growth	NOUN
can-1683	120	19	factors	factor	NOUN
can-1683	120	20	,	,	PUNCT
can-1683	120	21	cytokines	cytokine	NOUN
can-1683	120	22	,	,	PUNCT
can-1683	120	23	etc	etc	X
can-1683	120	24	.	.	X
can-1683	120	25	)	)	PUNCT
can-1683	120	26	in	in	ADP
can-1683	120	27	a	a	DET
can-1683	120	28	regulated	regulated	ADJ
can-1683	120	29	way	way	NOUN
can-1683	120	30	.	.	PUNCT
can-1683	121	1	gly	gly	ADJ
can-1683	121	2	-	-	PUNCT
can-1683	121	3	arg	arg	VERB
can-1683	121	4	-	-	PUNCT
can-1683	121	5	val	val	NOUN
can-1683	121	6	-	-	PUNCT
can-1683	121	7	tyr	tyr	PROPN
can-1683	121	8	-	-	PUNCT
can-1683	121	9	ile	ile	ADJ
can-1683	121	10	-	-	PUNCT
can-1683	121	11	his	his	PRON
can-1683	121	12	-	-	PUNCT
can-1683	121	13	pro	pro	ADJ
can-1683	121	14	-	-	ADJ
can-1683	121	15	phe	phe	ADJ
can-1683	121	16	(	(	PUNCT
can-1683	121	17	binding	bind	VERB
can-1683	121	18	sequence	sequence	NOUN
can-1683	121	19	of	of	ADP
can-1683	121	20	at1	at1	PROPN
can-1683	121	21	receptor	receptor	NOUN
can-1683	121	22	)	)	PUNCT
can-1683	121	23	is	be	AUX
can-1683	121	24	connected	connect	VERB
can-1683	121	25	to	to	ADP
can-1683	121	26	these	these	DET
can-1683	121	27	liposomes	liposome	NOUN
can-1683	121	28	,	,	PUNCT
can-1683	121	29	which	which	PRON
can-1683	121	30	might	might	AUX
can-1683	121	31	lead	lead	VERB
can-1683	121	32	the	the	DET
can-1683	121	33	nanoparticles	nanoparticle	NOUN
can-1683	121	34	to	to	ADP
can-1683	121	35	the	the	DET
can-1683	121	36	infarction	infarction	NOUN
can-1683	121	37	heart	heart	NOUN
can-1683	121	38	.	.	PUNCT
can-1683	122	1	3.4.2	3.4.2	NUM
can-1683	122	2	active	active	ADJ
can-1683	122	3	targeting	targeting	NOUN
can-1683	122	4	of	of	ADP
can-1683	122	5	macrophages	macrophage	NOUN
can-1683	122	6	or	or	CCONJ
can-1683	122	7	foam	foam	NOUN
can-1683	122	8	cells	cell	NOUN
can-1683	122	9	foam	foam	NOUN
can-1683	122	10	cells	cell	NOUN
can-1683	122	11	,	,	PUNCT
can-1683	122	12	also	also	ADV
can-1683	122	13	known	know	VERB
can-1683	122	14	as	as	ADP
can-1683	122	15	macrophages	macrophage	NOUN
can-1683	122	16	,	,	PUNCT
can-1683	122	17	play	play	VERB
can-1683	122	18	an	an	DET
can-1683	122	19	important	important	ADJ
can-1683	122	20	part	part	NOUN
can-1683	122	21	in	in	ADP
can-1683	122	22	the	the	DET
can-1683	122	23	development	development	NOUN
can-1683	122	24	of	of	ADP
can-1683	122	25	as	as	ADP
can-1683	122	26	.	.	PUNCT
can-1683	123	1	some	some	DET
can-1683	123	2	inflammation	inflammation	NOUN
can-1683	123	3	-	-	PUNCT
can-1683	123	4	related	relate	VERB
can-1683	123	5	molecules	molecule	NOUN
can-1683	123	6	,	,	PUNCT
can-1683	123	7	including	include	VERB
can-1683	123	8	as	as	ADP
can-1683	123	9	cd44	cd44	PROPN
can-1683	123	10	and	and	CCONJ
can-1683	123	11	interleukin-4	interleukin-4	PROPN
can-1683	123	12	(	(	PUNCT
can-1683	123	13	il-4	il-4	NOUN
can-1683	123	14	)	)	PUNCT
can-1683	123	15	receptors	receptor	NOUN
can-1683	123	16	,	,	PUNCT
can-1683	123	17	were	be	AUX
can-1683	123	18	overexpressed	overexpresse	VERB
can-1683	123	19	in	in	ADP
can-1683	123	20	an	an	DET
can-1683	123	21	inflammatory	inflammatory	ADJ
can-1683	123	22	environment	environment	NOUN
can-1683	123	23	by	by	ADP
can-1683	123	24	mononuclear	mononuclear	ADJ
can-1683	123	25	/	/	SYM
can-1683	123	26	macrophages	macrophage	NOUN
can-1683	123	27	in	in	ADP
can-1683	123	28	the	the	DET
can-1683	123	29	early	early	ADJ
can-1683	123	30	stages	stage	NOUN
can-1683	123	31	of	of	ADP
can-1683	123	32	as	as	ADP
can-1683	123	33	.	.	PUNCT
can-1683	124	1	in	in	ADP
can-1683	124	2	order	order	NOUN
can-1683	124	3	to	to	PART
can-1683	124	4	track	track	VERB
can-1683	124	5	the	the	DET
can-1683	124	6	course	course	NOUN
can-1683	124	7	of	of	ADP
can-1683	124	8	as	as	ADP
can-1683	124	9	and	and	CCONJ
can-1683	124	10	administer	administer	NOUN
can-1683	124	11	medication	medication	NOUN
can-1683	124	12	,	,	PUNCT
can-1683	124	13	nddss	nddss	NOUN
can-1683	124	14	can	can	AUX
can-1683	124	15	be	be	AUX
can-1683	124	16	used	use	VERB
can-1683	124	17	for	for	ADP
can-1683	124	18	imaging	imaging	NOUN
can-1683	124	19	and	and	CCONJ
can-1683	124	20	drug	drug	PROPN
can-1683	124	21	administration	administration	NOUN
can-1683	124	22	into	into	ADP
can-1683	124	23	macrophages	macrophage	NOUN
can-1683	124	24	or	or	CCONJ
can-1683	124	25	foam	foam	NOUN
can-1683	124	26	cells	cell	NOUN
can-1683	124	27	.	.	PUNCT
can-1683	125	1	when	when	SCONJ
can-1683	125	2	the	the	DET
can-1683	125	3	carboxyl	carboxyl	NOUN
can-1683	125	4	group	group	NOUN
can-1683	125	5	of	of	ADP
can-1683	125	6	the	the	DET
can-1683	125	7	ha	ha	INTJ
can-1683	125	8	skeleton	skeleton	PROPN
can-1683	125	9	was	be	AUX
can-1683	125	10	chemically	chemically	ADV
can-1683	125	11	coupled	couple	VERB
can-1683	125	12	to	to	ADP
can-1683	125	13	5	5	NUM
can-1683	125	14	-	-	PUNCT
can-1683	125	15	cholic	cholic	NOUN
can-1683	125	16	acid	acid	NOUN
can-1683	125	17	and	and	CCONJ
can-1683	125	18	the	the	DET
can-1683	125	19	fluorescent	fluorescent	ADJ
can-1683	125	20	dye	dye	NOUN
can-1683	125	21	cy5.5	cy5.5	NOUN
can-1683	125	22	,	,	PUNCT
can-1683	125	23	nanoparticles	nanoparticle	NOUN
can-1683	125	24	(	(	PUNCT
can-1683	125	25	ha	ha	INTJ
can-1683	125	26	-	-	PUNCT
can-1683	125	27	nps	nps	PROPN
can-1683	125	28	)	)	PUNCT
can-1683	125	29	were	be	AUX
can-1683	125	30	generated	generate	VERB
can-1683	125	31	by	by	ADP
can-1683	125	32	self	self	NOUN
can-1683	125	33	-	-	PUNCT
can-1683	125	34	assembly[31	assembly[31	NOUN
can-1683	125	35	]	]	PUNCT
can-1683	125	36	.	.	PUNCT
can-1683	126	1	it	it	PRON
can-1683	126	2	was	be	AUX
can-1683	126	3	shown	show	VERB
can-1683	126	4	that	that	SCONJ
can-1683	126	5	in	in	ADP
can-1683	126	6	comparison	comparison	NOUN
can-1683	126	7	to	to	ADP
can-1683	126	8	nanoparticles	nanoparticle	NOUN
can-1683	126	9	(	(	PUNCT
can-1683	126	10	hgc	hgc	PROPN
can-1683	126	11	-	-	PUNCT
can-1683	126	12	nps	nps	PROPN
can-1683	126	13	)	)	PUNCT
can-1683	126	14	made	make	VERB
can-1683	126	15	with	with	ADP
can-1683	126	16	chitosan	chitosan	NOUN
can-1683	126	17	backbones	backbone	NOUN
can-1683	126	18	that	that	PRON
can-1683	126	19	did	do	AUX
can-1683	126	20	not	not	PART
can-1683	126	21	target	target	VERB
can-1683	126	22	cd44	cd44	NOUN
can-1683	126	23	receptors	receptor	NOUN
can-1683	126	24	,	,	PUNCT
can-1683	126	25	ha	ha	NOUN
can-1683	126	26	-	-	NOUN
can-1683	126	27	np	np	INTJ
can-1683	126	28	could	could	AUX
can-1683	126	29	greatly	greatly	ADV
can-1683	126	30	improve	improve	VERB
can-1683	126	31	the	the	DET
can-1683	126	32	absorption	absorption	NOUN
can-1683	126	33	of	of	ADP
can-1683	126	34	activated	activated	ADJ
can-1683	126	35	macrophages	macrophage	NOUN
can-1683	126	36	,	,	PUNCT
can-1683	126	37	and	and	CCONJ
can-1683	126	38	the	the	DET
can-1683	126	39	plaque	plaque	NOUN
can-1683	126	40	site	site	NOUN
can-1683	126	41	of	of	ADP
can-1683	126	42	apoe	apoe	ADJ
can-1683	126	43	/	/	SYM
can-1683	126	44	mice	mouse	NOUN
can-1683	126	45	(	(	PUNCT
can-1683	126	46	as	as	ADP
can-1683	126	47	model	model	NOUN
can-1683	126	48	)	)	PUNCT
can-1683	126	49	was	be	AUX
can-1683	126	50	more	more	ADV
can-1683	126	51	targeted	targeted	ADJ
can-1683	126	52	.	.	PUNCT
can-1683	127	1	co	co	NOUN
can-1683	127	2	-	-	NOUN
can-1683	127	3	localization	localization	ADJ
can-1683	127	4	experiments	experiment	NOUN
can-1683	127	5	showed	show	VERB
can-1683	127	6	that	that	SCONJ
can-1683	127	7	ha	ha	NOUN
can-1683	127	8	-	-	PUNCT
can-1683	127	9	np	np	PROPN
can-1683	127	10	was	be	AUX
can-1683	127	11	mostly	mostly	ADV
can-1683	127	12	found	find	VERB
can-1683	127	13	in	in	ADP
can-1683	127	14	macrophages	macrophage	NOUN
can-1683	127	15	in	in	ADP
can-1683	127	16	plaques	plaque	NOUN
can-1683	127	17	.	.	PUNCT
can-1683	128	1	amphiphilicity	amphiphilicity	NOUN
can-1683	128	2	of	of	ADP
can-1683	128	3	the	the	DET
can-1683	128	4	il-4	il-4	NOUN
can-1683	128	5	receptor	receptor	NOUN
can-1683	128	6	peptide	peptide	NOUN
can-1683	128	7	was	be	AUX
can-1683	128	8	improved	improve	VERB
can-1683	128	9	by	by	ADP
can-1683	128	10	the	the	DET
can-1683	128	11	application	application	NOUN
can-1683	128	12	of	of	ADP
can-1683	128	13	phage	phage	NOUN
can-1683	128	14	library	library	NOUN
can-1683	128	15	screening	screen	VERB
can-1683	128	16	technology	technology	NOUN
can-1683	128	17	and	and	CCONJ
can-1683	128	18	chemical	chemical	NOUN
can-1683	128	19	bonding	bonding	NOUN
can-1683	128	20	to	to	ADP
can-1683	128	21	amphiphilic	amphiphilic	ADJ
can-1683	128	22	chitosan	chitosan	NOUN
can-1683	128	23	(	(	PUNCT
can-1683	128	24	with	with	ADP
can-1683	128	25	ethylene	ethylene	NOUN
can-1683	128	26	glycol	glycol	NOUN
can-1683	128	27	chitosan	chitosan	NOUN
can-1683	128	28	as	as	ADP
can-1683	128	29	the	the	DET
can-1683	128	30	backbone	backbone	NOUN
can-1683	128	31	and	and	CCONJ
can-1683	128	32	5	5	NUM
can-1683	128	33	-	-	PUNCT
can-1683	128	34	cholate	cholate	NOUN
can-1683	128	35	attached	attach	VERB
can-1683	128	36	)	)	PUNCT
can-1683	128	37	.	.	PUNCT
can-1683	129	1	self	self	NOUN
can-1683	129	2	-	-	PUNCT
can-1683	129	3	assembled	assemble	VERB
can-1683	129	4	nanoparticles	nanoparticle	NOUN
can-1683	129	5	having	have	VERB
can-1683	129	6	the	the	DET
can-1683	129	7	function	function	NOUN
can-1683	129	8	of	of	ADP
can-1683	129	9	targeting	target	VERB
can-1683	129	10	macrophages	macrophage	NOUN
can-1683	129	11	in	in	ADV
can-1683	129	12	as	as	SCONJ
can-1683	129	13	plaques	plaque	NOUN
can-1683	129	14	are	be	AUX
can-1683	129	15	then	then	ADV
can-1683	129	16	produced	produce	VERB
can-1683	129	17	.	.	PUNCT
can-1683	130	1	3.5	3.5	NUM
can-1683	130	2	targeting	target	VERB
can-1683	130	3	vascular	vascular	ADJ
can-1683	130	4	basement	basement	NOUN
can-1683	130	5	membrane	membrane	NOUN
can-1683	130	6	collagen	collagen	NOUN
can-1683	130	7	damaged	damage	VERB
can-1683	130	8	blood	blood	NOUN
can-1683	130	9	arteries	artery	NOUN
can-1683	130	10	and	and	CCONJ
can-1683	130	11	inflammatory	inflammatory	ADJ
can-1683	130	12	areas	area	NOUN
can-1683	130	13	have	have	VERB
can-1683	130	14	collagen	collagen	NOUN
can-1683	130	15	iv	iv	X
can-1683	130	16	(	(	PUNCT
can-1683	130	17	col	col	NOUN
can-1683	130	18	iv)-rich	iv)-rich	VERB
can-1683	130	19	vascular	vascular	ADJ
can-1683	130	20	basement	basement	NOUN
can-1683	130	21	membranes	membrane	NOUN
can-1683	130	22	,	,	PUNCT
can-1683	130	23	according	accord	VERB
can-1683	130	24	to	to	ADP
can-1683	130	25	research	research	NOUN
can-1683	130	26	.	.	PUNCT
can-1683	131	1	collagen	collagen	NOUN
can-1683	131	2	iv	iv	ADV
can-1683	131	3	-	-	PUNCT
can-1683	131	4	targeting	target	VERB
can-1683	131	5	nanoparticles	nanoparticle	NOUN
can-1683	131	6	(	(	PUNCT
can-1683	131	7	ac2	ac2	PROPN
can-1683	131	8	-	-	PUNCT
can-1683	131	9	26	26	NUM
can-1683	131	10	col	col	PROPN
can-1683	131	11	iv	iv	PROPN
can-1683	131	12	nps	nps	PROPN
can-1683	131	13	)	)	PUNCT
can-1683	131	14	were	be	AUX
can-1683	131	15	developed	develop	VERB
can-1683	131	16	in	in	ADP
can-1683	131	17	2013	2013	NUM
can-1683	131	18	by	by	ADP
can-1683	131	19	kamaly	kamaly	PROPN
can-1683	131	20	et	et	PROPN
can-1683	131	21	al	al	PROPN
can-1683	131	22	.	.	PUNCT
can-1683	131	23	by	by	ADP
can-1683	131	24	attaching	attach	VERB
can-1683	131	25	the	the	DET
can-1683	131	26	7	7	NUM
can-1683	131	27	amino	amino	NOUN
can-1683	131	28	acid	acid	NOUN
can-1683	131	29	oligopeptides	oligopeptide	NOUN
can-1683	131	30	to	to	ADP
can-1683	131	31	the	the	DET
can-1683	131	32	peg	peg	NOUN
can-1683	131	33	end	end	NOUN
can-1683	131	34	of	of	ADP
can-1683	131	35	the	the	DET
can-1683	131	36	plga	plga	NOUN
can-1683	131	37	–	–	PUNCT
can-1683	131	38	peg	peg	NOUN
can-1683	131	39	block	block	NOUN
can-1683	131	40	copolymer	copolymer	NOUN
can-1683	131	41	,	,	PUNCT
can-1683	131	42	and	and	CCONJ
can-1683	131	43	using	use	VERB
can-1683	131	44	it	it	PRON
can-1683	131	45	to	to	PART
can-1683	131	46	package	package	VERB
can-1683	131	47	act-26	act-26	PROPN
can-1683	131	48	(	(	PUNCT
can-1683	131	49	with	with	ADP
can-1683	131	50	anti	anti	ADJ
can-1683	131	51	-	-	ADJ
can-1683	131	52	inflammatory	inflammatory	ADJ
can-1683	131	53	and	and	CCONJ
can-1683	131	54	inhibition	inhibition	NOUN
can-1683	131	55	of	of	ADP
can-1683	131	56	leukocyte	leukocyte	ADJ
can-1683	131	57	extravasation	extravasation	NOUN
can-1683	131	58	)	)	PUNCT
can-1683	131	59	.	.	PUNCT
can-1683	132	1	act-26	act-26	PROPN
can-1683	132	2	col	col	PROPN
can-1683	132	3	iv	iv	PROPN
can-1683	132	4	nps	nps	PROPN
can-1683	132	5	were	be	AUX
can-1683	132	6	shown	show	VERB
can-1683	132	7	to	to	PART
can-1683	132	8	limit	limit	VERB
can-1683	132	9	neutrophil	neutrophil	ADJ
can-1683	132	10	migration	migration	NOUN
can-1683	132	11	and	and	CCONJ
can-1683	132	12	adherence	adherence	NOUN
can-1683	132	13	to	to	ADP
can-1683	132	14	the	the	DET
can-1683	132	15	inflammatory	inflammatory	ADJ
can-1683	132	16	site	site	NOUN
can-1683	132	17	and	and	CCONJ
can-1683	132	18	to	to	PART
can-1683	132	19	prevent	prevent	VERB
can-1683	132	20	inflammation	inflammation	NOUN
can-1683	132	21	development	development	NOUN
can-1683	132	22	.	.	PUNCT
can-1683	133	1	il-10	il-10	PRON
can-1683	133	2	nanoparticles	nanoparticle	NOUN
can-1683	133	3	(	(	PUNCT
can-1683	133	4	col	col	NOUN
can-1683	133	5	-	-	PUNCT
can-1683	133	6	iv	iv	PROPN
can-1683	133	7	il-10	il-10	NOUN
can-1683	133	8	nps	nps	PROPN
can-1683	133	9	)	)	PUNCT
can-1683	133	10	were	be	AUX
can-1683	133	11	also	also	ADV
can-1683	133	12	created	create	VERB
can-1683	133	13	in	in	ADP
can-1683	133	14	2016	2016	NUM
can-1683	133	15	by	by	ADP
can-1683	133	16	combining	combine	VERB
can-1683	133	17	plga	plga	NOUN
can-1683	133	18	-	-	PUNCT
can-1683	133	19	peg	peg	NOUN
can-1683	133	20	-	-	PUNCT
can-1683	133	21	col	col	NOUN
can-1683	133	22	iv	iv	NOUN
can-1683	133	23	and	and	CCONJ
can-1683	133	24	pdla	pdla	ADJ
can-1683	133	25	-	-	PUNCT
can-1683	133	26	peg	peg	NOUN
can-1683	133	27	-	-	PUNCT
can-1683	133	28	ome	ome	NOUN
can-1683	133	29	targeting	target	VERB
can-1683	133	30	collagen	collagen	NOUN
can-1683	133	31	lv	lv	PROPN
can-1683	133	32	with	with	ADP
can-1683	133	33	self	self	NOUN
can-1683	133	34	-	-	PUNCT
can-1683	133	35	assembly[32	assembly[32	VERB
can-1683	133	36	]	]	PUNCT
can-1683	133	37	.	.	PUNCT
can-1683	134	1	col	col	PROPN
can-1683	134	2	-	-	PUNCT
can-1683	134	3	iv	iv	PROPN
can-1683	134	4	il-10	il-10	NOUN
can-1683	134	5	np	np	INTJ
can-1683	134	6	considerably	considerably	ADV
can-1683	134	7	boosted	boost	VERB
can-1683	134	8	the	the	DET
can-1683	134	9	plaque	plaque	NOUN
can-1683	134	10	’s	’s	NOUN
can-1683	134	11	il-10	il-10	NOUN
can-1683	134	12	content	content	NOUN
can-1683	134	13	after	after	ADP
can-1683	134	14	being	be	AUX
can-1683	134	15	administered	administer	VERB
can-1683	134	16	intravenously	intravenously	ADV
can-1683	134	17	to	to	ADP
can-1683	134	18	ldlr	ldlr	VERB
can-1683	134	19	/	/	SYM
can-1683	134	20	mice	mouse	NOUN
can-1683	134	21	and	and	CCONJ
can-1683	134	22	had	have	VERB
can-1683	134	23	a	a	DET
can-1683	134	24	greater	great	ADJ
can-1683	134	25	impact	impact	NOUN
can-1683	134	26	on	on	ADP
can-1683	134	27	as	as	ADP
can-1683	134	28	therapy	therapy	NOUN
can-1683	134	29	than	than	ADP
can-1683	134	30	free	free	ADJ
can-1683	134	31	il-10	il-10	PRON
can-1683	134	32	.	.	PUNCT
can-1683	135	1	additional	additional	ADJ
can-1683	135	2	research	research	NOUN
can-1683	135	3	has	have	AUX
can-1683	135	4	focused	focus	VERB
can-1683	135	5	on	on	ADP
can-1683	135	6	nanocarriers	nanocarrier	NOUN
can-1683	135	7	that	that	PRON
can-1683	135	8	can	can	AUX
can-1683	135	9	deliver	deliver	VERB
can-1683	135	10	numerous	numerous	ADJ
can-1683	135	11	anti	anti	ADJ
can-1683	135	12	-	-	ADJ
can-1683	135	13	inflammatory	inflammatory	ADJ
can-1683	135	14	agents	agent	NOUN
can-1683	135	15	to	to	ADP
can-1683	135	16	distinct	distinct	ADJ
can-1683	135	17	types	type	NOUN
can-1683	135	18	of	of	ADP
can-1683	135	19	cells	cell	NOUN
can-1683	135	20	in	in	ADP
can-1683	135	21	the	the	DET
can-1683	135	22	body	body	NOUN
can-1683	135	23	.	.	PUNCT
can-1683	136	1	platelet	platelet	ADJ
can-1683	136	2	-	-	PUNCT
can-1683	136	3	mimetic	mimetic	ADJ
can-1683	136	4	discoid	discoid	NOUN
can-1683	136	5	morphology	morphology	NOUN
can-1683	136	6	and	and	CCONJ
can-1683	136	7	flexibility	flexibility	NOUN
can-1683	136	8	were	be	AUX
can-1683	136	9	integrated	integrate	VERB
can-1683	136	10	with	with	ADP
can-1683	136	11	the	the	DET
can-1683	136	12	platelet	platelet	NOUN
can-1683	136	13	-	-	PUNCT
can-1683	136	14	mimetic	mimetic	ADJ
can-1683	136	15	biochemical	biochemical	ADJ
can-1683	136	16	heteromultivalent	heteromultivalent	NOUN
can-1683	136	17	interactive	interactive	ADJ
can-1683	136	18	functions	function	NOUN
can-1683	136	19	by	by	ADP
can-1683	136	20	dendritic	dendritic	ADJ
can-1683	136	21	presentation	presentation	NOUN
can-1683	136	22	of	of	ADP
can-1683	136	23	multiple	multiple	ADJ
can-1683	136	24	peptides	peptide	NOUN
can-1683	136	25	that	that	PRON
can-1683	136	26	bind	bind	VERB
can-1683	136	27	simultaneously	simultaneously	ADV
can-1683	136	28	to	to	ADP
can-1683	136	29	both	both	CCONJ
can-1683	136	30	activated	activate	VERB
can-1683	136	31	natural	natural	ADJ
can-1683	136	32	platelets	platelet	NOUN
can-1683	136	33	and	and	CCONJ
can-1683	136	34	injured	injure	VERB
can-1683	136	35	endothelial	endothelial	NOUN
can-1683	136	36	sites	site	NOUN
can-1683	136	37	by	by	ADP
can-1683	136	38	dendritic	dendritic	ADJ
can-1683	136	39	presentation	presentation	NOUN
can-1683	136	40	of	of	ADP
can-1683	136	41	multiple	multiple	ADJ
can-1683	136	42	peptides[33	peptides[33	NOUN
can-1683	136	43	]	]	PUNCT
can-1683	136	44	.	.	PUNCT
can-1683	137	1	nanoparticles	nanoparticle	NOUN
can-1683	137	2	’	'	PUNCT
can-1683	137	3	biological	biological	ADJ
can-1683	137	4	and	and	CCONJ
can-1683	137	5	physical	physical	ADJ
can-1683	137	6	features	feature	NOUN
can-1683	137	7	determine	determine	VERB
can-1683	137	8	whether	whether	SCONJ
can-1683	137	9	they	they	PRON
can-1683	137	10	are	be	AUX
can-1683	137	11	passively	passively	ADV
can-1683	137	12	targeted	target	VERB
can-1683	137	13	or	or	CCONJ
can-1683	137	14	actively	actively	ADV
can-1683	137	15	targeted	target	VERB
can-1683	137	16	.	.	PUNCT
can-1683	138	1	particle	particle	NOUN
can-1683	138	2	size	size	NOUN
can-1683	138	3	and	and	CCONJ
can-1683	138	4	distribution	distribution	NOUN
can-1683	138	5	,	,	PUNCT
can-1683	138	6	targeting	target	VERB
can-1683	138	7	unit	unit	NOUN
can-1683	138	8	kinds	kind	NOUN
can-1683	138	9	,	,	PUNCT
can-1683	138	10	surface	surface	NOUN
can-1683	138	11	chemistry	chemistry	NOUN
can-1683	138	12	,	,	PUNCT
can-1683	138	13	morphology	morphology	NOUN
can-1683	138	14	,	,	PUNCT
can-1683	138	15	and	and	CCONJ
can-1683	138	16	density	density	NOUN
can-1683	138	17	are	be	AUX
can-1683	138	18	all	all	PRON
can-1683	138	19	examples	example	NOUN
can-1683	138	20	of	of	ADP
can-1683	138	21	biological	biological	ADJ
can-1683	138	22	and	and	CCONJ
can-1683	138	23	physical	physical	ADJ
can-1683	138	24	features	feature	NOUN
can-1683	138	25	.	.	PUNCT
can-1683	139	1	the	the	DET
can-1683	139	2	development	development	NOUN
can-1683	139	3	stage	stage	NOUN
can-1683	139	4	,	,	PUNCT
can-1683	139	5	type	type	NOUN
can-1683	139	6	and	and	CCONJ
can-1683	139	7	location	location	NOUN
can-1683	139	8	of	of	ADP
can-1683	139	9	cvds	cvds	PROPN
can-1683	139	10	and	and	CCONJ
can-1683	139	11	tumors	tumor	NOUN
can-1683	139	12	,	,	PUNCT
can-1683	139	13	vascular	vascular	ADJ
can-1683	139	14	wall	wall	NOUN
can-1683	139	15	shear	shear	NOUN
can-1683	139	16	rate	rate	NOUN
can-1683	139	17	,	,	PUNCT
can-1683	139	18	blood	blood	NOUN
can-1683	139	19	composition	composition	NOUN
can-1683	139	20	and	and	CCONJ
can-1683	139	21	its	its	PRON
can-1683	139	22	fluid	fluid	ADJ
can-1683	139	23	type	type	NOUN
can-1683	139	24	,	,	PUNCT
can-1683	139	25	as	as	ADV
can-1683	139	26	well	well	ADV
can-1683	139	27	as	as	ADP
can-1683	139	28	other	other	ADJ
can-1683	139	29	elements	element	NOUN
can-1683	139	30	,	,	PUNCT
can-1683	139	31	will	will	AUX
can-1683	139	32	have	have	VERB
can-1683	139	33	a	a	DET
can-1683	139	34	significant	significant	ADJ
can-1683	139	35	impact	impact	NOUN
can-1683	139	36	on	on	ADP
can-1683	139	37	the	the	DET
can-1683	139	38	targeting	targeting	NOUN
can-1683	139	39	efficiency	efficiency	NOUN
can-1683	139	40	for	for	ADP
can-1683	139	41	the	the	DET
can-1683	139	42	body[34	body[34	NOUN
can-1683	139	43	]	]	PUNCT
can-1683	139	44	.	.	PUNCT
can-1683	140	1	however	however	ADV
can-1683	140	2	,	,	PUNCT
can-1683	140	3	even	even	ADV
can-1683	140	4	though	though	SCONJ
can-1683	140	5	the	the	DET
can-1683	140	6	use	use	NOUN
can-1683	140	7	of	of	ADP
can-1683	140	8	active	active	ADJ
can-1683	140	9	targeted	target	VERB
can-1683	140	10	nddss	nddss	NOUN
can-1683	140	11	in	in	ADP
can-1683	140	12	clinical	clinical	ADJ
can-1683	140	13	diagnosis	diagnosis	NOUN
can-1683	140	14	and	and	CCONJ
can-1683	140	15	treatment	treatment	NOUN
can-1683	140	16	is	be	AUX
can-1683	140	17	exceedingly	exceedingly	ADV
can-1683	140	18	appealing	appealing	ADJ
can-1683	140	19	,	,	PUNCT
can-1683	140	20	their	their	PRON
can-1683	140	21	development	development	NOUN
can-1683	140	22	is	be	AUX
can-1683	140	23	still	still	ADV
can-1683	140	24	hampered	hamper	VERB
can-1683	140	25	by	by	ADP
can-1683	140	26	several	several	ADJ
can-1683	140	27	dif	dif	ADJ
can-1683	140	28	15	15	NUM
can-1683	140	29	ficulties	ficultie	NOUN
can-1683	140	30	.	.	PUNCT
can-1683	141	1	as	as	ADP
can-1683	141	2	a	a	DET
can-1683	141	3	result	result	NOUN
can-1683	141	4	of	of	ADP
can-1683	141	5	these	these	DET
can-1683	141	6	issues	issue	NOUN
can-1683	141	7	,	,	PUNCT
can-1683	141	8	there	there	PRON
can-1683	141	9	are	be	VERB
can-1683	141	10	two	two	NUM
can-1683	141	11	primary	primary	ADJ
can-1683	141	12	aspects	aspect	NOUN
can-1683	141	13	:	:	PUNCT
can-1683	141	14	one	one	NUM
can-1683	141	15	is	be	AUX
can-1683	141	16	the	the	DET
can-1683	141	17	inability	inability	NOUN
can-1683	141	18	to	to	PART
can-1683	141	19	locate	locate	VERB
can-1683	141	20	an	an	DET
can-1683	141	21	optimal	optimal	ADJ
can-1683	141	22	target	target	NOUN
can-1683	141	23	;	;	PUNCT
can-1683	141	24	the	the	DET
can-1683	141	25	other	other	ADJ
can-1683	141	26	is	be	AUX
can-1683	141	27	the	the	DET
can-1683	141	28	difficulty	difficulty	NOUN
can-1683	141	29	in	in	ADP
can-1683	141	30	designing	design	VERB
can-1683	141	31	and	and	CCONJ
can-1683	141	32	preparing	prepare	VERB
can-1683	141	33	effective	effective	ADJ
can-1683	141	34	nanosystems	nanosystem	NOUN
can-1683	141	35	.	.	PUNCT
can-1683	142	1	4	4	X
can-1683	142	2	.	.	X
can-1683	142	3	multifunctional	multifunctional	ADJ
can-1683	142	4	responsiveness	responsiveness	NOUN
can-1683	142	5	nddss	nddss	ADV
can-1683	142	6	with	with	ADP
can-1683	142	7	the	the	DET
can-1683	142	8	principles	principle	NOUN
can-1683	142	9	of	of	ADP
can-1683	142	10	the	the	DET
can-1683	142	11	aforementioned	aforementioned	ADJ
can-1683	142	12	two	two	NUM
can-1683	142	13	targeting	target	VERB
can-1683	142	14	mechanisms	mechanism	NOUN
can-1683	142	15	,	,	PUNCT
can-1683	142	16	nano	nano	NOUN
can-1683	142	17	-	-	PUNCT
can-1683	142	18	drug	drug	NOUN
can-1683	142	19	carriers	carrier	NOUN
can-1683	142	20	could	could	AUX
can-1683	142	21	be	be	AUX
can-1683	142	22	produced	produce	VERB
can-1683	142	23	that	that	PRON
can-1683	142	24	would	would	AUX
can-1683	142	25	have	have	VERB
can-1683	142	26	a	a	DET
can-1683	142	27	superior	superior	ADJ
can-1683	142	28	ability	ability	NOUN
can-1683	142	29	to	to	PART
can-1683	142	30	target	target	VERB
can-1683	142	31	.	.	PUNCT
can-1683	143	1	these	these	DET
can-1683	143	2	nanocarriers	nanocarrier	NOUN
can-1683	143	3	are	be	AUX
can-1683	143	4	often	often	ADV
can-1683	143	5	constituted	constitute	VERB
can-1683	143	6	of	of	ADP
can-1683	143	7	stimulatory	stimulatory	ADJ
can-1683	143	8	responsive	responsive	ADJ
can-1683	143	9	materials	material	NOUN
can-1683	143	10	,	,	PUNCT
can-1683	143	11	which	which	PRON
can-1683	143	12	may	may	AUX
can-1683	143	13	be	be	AUX
can-1683	143	14	released	release	VERB
can-1683	143	15	under	under	ADP
can-1683	143	16	the	the	DET
can-1683	143	17	stimulation	stimulation	NOUN
can-1683	143	18	of	of	ADP
can-1683	143	19	a	a	DET
can-1683	143	20	specific	specific	ADJ
can-1683	143	21	environment	environment	NOUN
can-1683	143	22	,	,	PUNCT
can-1683	143	23	thereby	thereby	ADV
can-1683	143	24	decreasing	decrease	VERB
can-1683	143	25	release	release	NOUN
can-1683	143	26	in	in	ADP
can-1683	143	27	normal	normal	ADJ
can-1683	143	28	tissue	tissue	NOUN
can-1683	143	29	and	and	CCONJ
can-1683	143	30	enhancing	enhance	VERB
can-1683	143	31	drug	drug	NOUN
can-1683	143	32	accumulation	accumulation	NOUN
can-1683	143	33	at	at	ADP
can-1683	143	34	the	the	DET
can-1683	143	35	focal	focal	ADJ
can-1683	143	36	site	site	NOUN
can-1683	143	37	.	.	PUNCT
can-1683	144	1	when	when	SCONJ
can-1683	144	2	combined	combine	VERB
can-1683	144	3	with	with	ADP
can-1683	144	4	other	other	ADJ
can-1683	144	5	diagnostic	diagnostic	ADJ
can-1683	144	6	compounds	compound	NOUN
can-1683	144	7	like	like	ADP
can-1683	144	8	volatile	volatile	ADJ
can-1683	144	9	organic	organic	ADJ
can-1683	144	10	compounds	compound	NOUN
can-1683	144	11	,	,	PUNCT
can-1683	144	12	halogen	halogen	NOUN
can-1683	144	13	containing	contain	VERB
can-1683	144	14	compounds	compound	NOUN
can-1683	144	15	and	and	CCONJ
can-1683	144	16	many	many	ADJ
can-1683	144	17	,	,	PUNCT
can-1683	144	18	nanocarriers	nanocarrier	NOUN
can-1683	144	19	can	can	AUX
can-1683	144	20	form	form	VERB
can-1683	144	21	an	an	DET
can-1683	144	22	integrated	integrated	ADJ
can-1683	144	23	diagnosis	diagnosis	NOUN
can-1683	144	24	and	and	CCONJ
can-1683	144	25	treatment	treatment	NOUN
can-1683	144	26	system	system	NOUN
can-1683	144	27	.	.	PUNCT
can-1683	145	1	5	5	X
can-1683	145	2	.	.	X
can-1683	145	3	application	application	NOUN
can-1683	145	4	of	of	ADP
can-1683	145	5	the	the	DET
can-1683	145	6	nddss	nddss	NOUN
can-1683	145	7	in	in	ADP
can-1683	145	8	the	the	DET
can-1683	145	9	diagnosis	diagnosis	NOUN
can-1683	145	10	of	of	ADP
can-1683	145	11	cvds	cvds	PROPN
can-1683	145	12	effective	effective	PROPN
can-1683	145	13	cvd	cvd	PROPN
can-1683	145	14	prevention	prevention	PROPN
can-1683	145	15	and	and	CCONJ
can-1683	145	16	therapy	therapy	NOUN
can-1683	145	17	depend	depend	VERB
can-1683	145	18	on	on	ADP
can-1683	145	19	early	early	ADJ
can-1683	145	20	,	,	PUNCT
can-1683	145	21	quick	quick	ADJ
can-1683	145	22	,	,	PUNCT
can-1683	145	23	and	and	CCONJ
can-1683	145	24	precise	precise	ADJ
can-1683	145	25	identification	identification	NOUN
can-1683	145	26	.	.	PUNCT
can-1683	146	1	there	there	PRON
can-1683	146	2	has	have	AUX
can-1683	146	3	been	be	AUX
can-1683	146	4	an	an	DET
can-1683	146	5	increase	increase	NOUN
can-1683	146	6	in	in	ADP
can-1683	146	7	the	the	DET
can-1683	146	8	use	use	NOUN
can-1683	146	9	of	of	ADP
can-1683	146	10	molecular	molecular	ADJ
can-1683	146	11	imaging	imaging	NOUN
can-1683	146	12	in	in	ADP
can-1683	146	13	the	the	DET
can-1683	146	14	diagnosis	diagnosis	NOUN
can-1683	146	15	of	of	ADP
can-1683	146	16	cardiovascular	cardiovascular	ADJ
can-1683	146	17	diseases	disease	NOUN
can-1683	146	18	in	in	ADP
can-1683	146	19	the	the	DET
can-1683	146	20	last	last	ADJ
can-1683	146	21	few	few	ADJ
can-1683	146	22	years	year	NOUN
can-1683	146	23	.	.	PUNCT
can-1683	147	1	additionally	additionally	ADV
can-1683	147	2	,	,	PUNCT
can-1683	147	3	new	new	ADJ
can-1683	147	4	contrast	contrast	NOUN
can-1683	147	5	agents	agent	NOUN
can-1683	147	6	are	be	AUX
can-1683	147	7	essential	essential	ADJ
can-1683	147	8	for	for	ADP
can-1683	147	9	real	real	ADJ
can-1683	147	10	-	-	PUNCT
can-1683	147	11	time	time	NOUN
can-1683	147	12	high	high	ADJ
can-1683	147	13	sensitivity	sensitivity	NOUN
can-1683	147	14	and	and	CCONJ
can-1683	147	15	high	high	ADJ
can-1683	147	16	resolution	resolution	NOUN
can-1683	147	17	diagnostics	diagnostic	NOUN
can-1683	147	18	,	,	PUNCT
can-1683	147	19	in	in	ADP
can-1683	147	20	addition	addition	NOUN
can-1683	147	21	to	to	ADP
can-1683	147	22	the	the	DET
can-1683	147	23	continual	continual	ADJ
can-1683	147	24	invention	invention	NOUN
can-1683	147	25	of	of	ADP
can-1683	147	26	various	various	ADJ
can-1683	147	27	imaging	imaging	NOUN
can-1683	147	28	modalities	modality	NOUN
can-1683	147	29	.	.	PUNCT
can-1683	148	1	nano	nano	NOUN
can-1683	148	2	-	-	PUNCT
can-1683	148	3	contrast	contrast	NOUN
can-1683	148	4	agents	agent	NOUN
can-1683	148	5	have	have	VERB
can-1683	148	6	the	the	DET
can-1683	148	7	following	follow	VERB
can-1683	148	8	benefits	benefit	NOUN
can-1683	148	9	over	over	ADP
can-1683	148	10	traditional	traditional	ADJ
can-1683	148	11	contrast	contrast	NOUN
can-1683	148	12	agents	agent	NOUN
can-1683	148	13	.	.	PUNCT
can-1683	149	1	there	there	PRON
can-1683	149	2	will	will	AUX
can-1683	149	3	be	be	AUX
can-1683	149	4	improvements	improvement	NOUN
can-1683	149	5	in	in	ADP
can-1683	149	6	the	the	DET
can-1683	149	7	following	follow	VERB
can-1683	149	8	areas	area	NOUN
can-1683	149	9	:	:	PUNCT
can-1683	149	10	(	(	PUNCT
can-1683	149	11	1	1	X
can-1683	149	12	)	)	PUNCT
can-1683	149	13	in	in	ADP
can-1683	149	14	vivo	vivo	ADJ
can-1683	149	15	stabilization	stabilization	NOUN
can-1683	149	16	;	;	PUNCT
can-1683	149	17	(	(	PUNCT
can-1683	149	18	2	2	X
can-1683	149	19	)	)	PUNCT
can-1683	149	20	controllable	controllable	ADJ
can-1683	149	21	physical	physical	ADJ
can-1683	149	22	and	and	CCONJ
can-1683	149	23	chemical	chemical	NOUN
can-1683	149	24	properties	property	NOUN
can-1683	149	25	(	(	PUNCT
can-1683	149	26	like	like	ADP
can-1683	149	27	chemical	chemical	NOUN
can-1683	149	28	composition	composition	NOUN
can-1683	149	29	and	and	CCONJ
can-1683	149	30	size	size	NOUN
can-1683	149	31	)	)	PUNCT
can-1683	149	32	and	and	CCONJ
can-1683	149	33	imaging	imaging	NOUN
can-1683	149	34	performance	performance	NOUN
can-1683	149	35	;	;	PUNCT
can-1683	149	36	(	(	PUNCT
can-1683	149	37	3	3	X
can-1683	149	38	)	)	PUNCT
can-1683	149	39	specific	specific	ADJ
can-1683	149	40	identification	identification	NOUN
can-1683	149	41	of	of	ADP
can-1683	149	42	specific	specific	ADJ
can-1683	149	43	biomolecules	biomolecule	NOUN
can-1683	149	44	;	;	PUNCT
can-1683	149	45	(	(	PUNCT
can-1683	149	46	4	4	X
can-1683	149	47	)	)	PUNCT
can-1683	149	48	multimodal	multimodal	ADJ
can-1683	149	49	imaging	imaging	NOUN
can-1683	149	50	capability	capability	NOUN
can-1683	149	51	;	;	PUNCT
can-1683	149	52	(	(	PUNCT
can-1683	149	53	5	5	X
can-1683	149	54	)	)	PUNCT
can-1683	149	55	potential	potential	ADJ
can-1683	149	56	benefits	benefit	NOUN
can-1683	149	57	for	for	ADP
can-1683	149	58	personalized	personalized	ADJ
can-1683	149	59	treatment	treatment	NOUN
can-1683	149	60	and	and	CCONJ
can-1683	149	61	diagnosis	diagnosis	NOUN
can-1683	149	62	.	.	PUNCT
can-1683	150	1	nano	nano	NOUN
can-1683	150	2	-	-	NOUN
can-1683	150	3	probes	probe	NOUN
can-1683	150	4	with	with	ADP
can-1683	150	5	distinct	distinct	ADJ
can-1683	150	6	chemical	chemical	NOUN
can-1683	150	7	signal	signal	NOUN
can-1683	150	8	molecules	molecule	NOUN
can-1683	150	9	of	of	ADP
can-1683	150	10	sick	sick	ADJ
can-1683	150	11	tissues	tissue	NOUN
can-1683	150	12	defined	define	VERB
can-1683	150	13	by	by	ADP
can-1683	150	14	pathological	pathological	ADJ
can-1683	150	15	investigations	investigation	NOUN
can-1683	150	16	can	can	AUX
can-1683	150	17	be	be	AUX
can-1683	150	18	used	use	VERB
can-1683	150	19	to	to	PART
can-1683	150	20	drive	drive	VERB
can-1683	150	21	the	the	DET
can-1683	150	22	contrast	contrast	NOUN
can-1683	150	23	agent	agent	NOUN
can-1683	150	24	to	to	ADP
can-1683	150	25	the	the	DET
can-1683	150	26	lesion	lesion	NOUN
can-1683	150	27	location	location	NOUN
can-1683	150	28	for	for	ADP
can-1683	150	29	mri	mri	NOUN
can-1683	150	30	,	,	PUNCT
can-1683	150	31	x	x	ADJ
can-1683	150	32	-	-	NOUN
can-1683	150	33	ray	ray	NOUN
can-1683	150	34	imaging	imaging	NOUN
can-1683	150	35	,	,	PUNCT
can-1683	150	36	fluorescence	fluorescence	NOUN
can-1683	150	37	imaging	imaging	NOUN
can-1683	150	38	,	,	PUNCT
can-1683	150	39	and	and	CCONJ
can-1683	150	40	contrast	contrast	NOUN
can-1683	150	41	-	-	PUNCT
can-1683	150	42	enhanced	enhance	VERB
can-1683	150	43	ultrasound	ultrasound	NOUN
can-1683	150	44	(	(	PUNCT
can-1683	150	45	us	us	PROPN
can-1683	150	46	)	)	PUNCT
can-1683	150	47	imaging	imaging	NOUN
can-1683	150	48	in	in	ADP
can-1683	150	49	the	the	DET
can-1683	150	50	early	early	ADJ
can-1683	150	51	stages	stage	NOUN
can-1683	150	52	of	of	ADP
can-1683	150	53	the	the	DET
can-1683	150	54	illness	illness	NOUN
can-1683	150	55	.	.	PUNCT
can-1683	151	1	also	also	ADV
can-1683	151	2	optical	optical	ADJ
can-1683	151	3	coherence	coherence	NOUN
can-1683	151	4	tomography	tomography	NOUN
can-1683	151	5	(	(	PUNCT
can-1683	151	6	oct	oct	NOUN
can-1683	151	7	)	)	PUNCT
can-1683	151	8	using	use	VERB
can-1683	151	9	aunps	aunps	NOUN
can-1683	151	10	and	and	CCONJ
can-1683	151	11	photoacoustic	photoacoustic	ADJ
can-1683	151	12	molecular	molecular	ADJ
can-1683	151	13	probe	probe	NOUN
can-1683	151	14	are	be	AUX
can-1683	151	15	in	in	ADP
can-1683	151	16	existence	existence	NOUN
can-1683	151	17	to	to	PART
can-1683	151	18	diagnose	diagnose	VERB
can-1683	151	19	cvds	cvds	NOUN
can-1683	151	20	.	.	PUNCT
can-1683	152	1	5.1	5.1	NUM
can-1683	152	2	magnetic	magnetic	ADJ
can-1683	152	3	resonance	resonance	NOUN
can-1683	152	4	imaging	imaging	NOUN
can-1683	152	5	magnetic	magnetic	ADJ
can-1683	152	6	resonance	resonance	NOUN
can-1683	152	7	imaging	imaging	NOUN
can-1683	152	8	(	(	PUNCT
can-1683	152	9	mri	mri	NOUN
can-1683	152	10	)	)	PUNCT
can-1683	152	11	is	be	AUX
can-1683	152	12	a	a	DET
can-1683	152	13	non	non	ADJ
can-1683	152	14	-	-	ADJ
can-1683	152	15	invasive	invasive	ADJ
can-1683	152	16	,	,	PUNCT
can-1683	152	17	safe	safe	ADJ
can-1683	152	18	,	,	PUNCT
can-1683	152	19	and	and	CCONJ
can-1683	152	20	high	high	ADJ
can-1683	152	21	-	-	PUNCT
can-1683	152	22	resolution	resolution	NOUN
can-1683	152	23	imaging	imaging	NOUN
can-1683	152	24	technique	technique	NOUN
can-1683	152	25	that	that	PRON
can-1683	152	26	is	be	AUX
can-1683	152	27	particularly	particularly	ADV
can-1683	152	28	useful	useful	ADJ
can-1683	152	29	for	for	ADP
can-1683	152	30	studying	study	VERB
can-1683	152	31	soft	soft	ADJ
can-1683	152	32	tissues	tissue	NOUN
can-1683	152	33	.	.	PUNCT
can-1683	153	1	however	however	ADV
can-1683	153	2	,	,	PUNCT
can-1683	153	3	mri	mri	PROPN
can-1683	153	4	’s	’s	PART
can-1683	153	5	sensitivity	sensitivity	NOUN
can-1683	153	6	ranges	range	VERB
can-1683	153	7	from	from	ADP
can-1683	153	8	103	103	NUM
can-1683	153	9	to	to	PART
can-1683	153	10	109	109	NUM
can-1683	153	11	m	m	NOUN
can-1683	153	12	,	,	PUNCT
can-1683	153	13	which	which	PRON
can-1683	153	14	is	be	AUX
can-1683	153	15	n’t	not	PART
can-1683	153	16	very	very	ADV
can-1683	153	17	high	high	ADJ
can-1683	153	18	.	.	PUNCT
can-1683	154	1	t1	t1	NOUN
can-1683	154	2	-	-	PUNCT
can-1683	154	3	weighted	weight	VERB
can-1683	154	4	imaging	imaging	NOUN
can-1683	154	5	contrast	contrast	NOUN
can-1683	154	6	agents	agent	NOUN
can-1683	154	7	,	,	PUNCT
can-1683	154	8	such	such	ADJ
can-1683	154	9	as	as	ADP
can-1683	154	10	gadolinium	gadolinium	NOUN
can-1683	154	11	complexes	complex	NOUN
can-1683	154	12	,	,	PUNCT
can-1683	154	13	are	be	AUX
can-1683	154	14	routinely	routinely	ADV
can-1683	154	15	employed	employ	VERB
can-1683	154	16	in	in	ADP
can-1683	154	17	clinical	clinical	ADJ
can-1683	154	18	practice	practice	NOUN
can-1683	154	19	;	;	PUNCT
can-1683	154	20	nonetheless	nonetheless	ADV
can-1683	154	21	,	,	PUNCT
can-1683	154	22	gadolinium	gadolinium	NOUN
can-1683	154	23	has	have	VERB
can-1683	154	24	some	some	DET
can-1683	154	25	nephrotoxicity	nephrotoxicity	NOUN
can-1683	154	26	.	.	PUNCT
can-1683	155	1	non	non	ADJ
can-1683	155	2	-	-	ADJ
can-1683	155	3	toxic	toxic	ADJ
can-1683	155	4	t2	t2	NOUN
can-1683	155	5	-	-	PUNCT
can-1683	155	6	weighted	weight	VERB
can-1683	155	7	mri	mri	NOUN
can-1683	155	8	contrast	contrast	NOUN
can-1683	155	9	agents	agent	NOUN
can-1683	155	10	are	be	AUX
can-1683	155	11	fe3o4	fe3o4	NOUN
can-1683	155	12	nanoparticle[35	nanoparticle[35	PROPN
can-1683	155	13	]	]	PUNCT
can-1683	155	14	.	.	PUNCT
can-1683	156	1	in	in	ADP
can-1683	156	2	comparison	comparison	NOUN
can-1683	156	3	to	to	ADP
can-1683	156	4	tinctures	tincture	NOUN
can-1683	156	5	,	,	PUNCT
can-1683	156	6	their	their	PRON
can-1683	156	7	sensitivity	sensitivity	NOUN
can-1683	156	8	,	,	PUNCT
can-1683	156	9	tissue	tissue	NOUN
can-1683	156	10	compatibility	compatibility	NOUN
can-1683	156	11	,	,	PUNCT
can-1683	156	12	and	and	CCONJ
can-1683	156	13	superparamagnetism	superparamagnetism	NOUN
can-1683	156	14	are	be	AUX
can-1683	156	15	far	far	ADV
can-1683	156	16	higher	high	ADJ
can-1683	156	17	,	,	PUNCT
can-1683	156	18	and	and	CCONJ
can-1683	156	19	they	they	PRON
can-1683	156	20	’re	’re	VERB
can-1683	156	21	also	also	ADV
can-1683	156	22	more	more	ADV
can-1683	156	23	potent	potent	ADJ
can-1683	156	24	.	.	PUNCT
can-1683	157	1	a	a	DET
can-1683	157	2	high	high	ADJ
can-1683	157	3	signal	signal	NOUN
can-1683	157	4	to	to	PART
can-1683	157	5	noise	noise	NOUN
can-1683	157	6	ratio	ratio	NOUN
can-1683	157	7	is	be	AUX
can-1683	157	8	achieved	achieve	VERB
can-1683	157	9	by	by	ADP
can-1683	157	10	using	use	VERB
can-1683	157	11	targeted	target	VERB
can-1683	157	12	contrast	contrast	NOUN
can-1683	157	13	agents	agent	NOUN
can-1683	157	14	to	to	PART
can-1683	157	15	collect	collect	VERB
can-1683	157	16	mri	mri	NOUN
can-1683	157	17	probes	probe	NOUN
can-1683	157	18	at	at	ADP
can-1683	157	19	a	a	DET
can-1683	157	20	high	high	ADJ
can-1683	157	21	concentration	concentration	NOUN
can-1683	157	22	(	(	PUNCT
can-1683	157	23	in	in	ADP
can-1683	157	24	micrograms	microgram	NOUN
can-1683	157	25	to	to	ADP
can-1683	157	26	milligrammes	milligramme	NOUN
can-1683	157	27	)	)	PUNCT
can-1683	157	28	in	in	ADP
can-1683	157	29	the	the	DET
can-1683	157	30	target	target	NOUN
can-1683	157	31	tissue	tissue	NOUN
can-1683	157	32	.	.	PUNCT
can-1683	158	1	preliminary	preliminary	ADJ
can-1683	158	2	vascular	vascular	ADJ
can-1683	158	3	imaging	imaging	NOUN
can-1683	158	4	may	may	AUX
can-1683	158	5	be	be	AUX
can-1683	158	6	conducted	conduct	VERB
can-1683	158	7	at	at	ADP
can-1683	158	8	an	an	DET
can-1683	158	9	early	early	ADJ
can-1683	158	10	stage	stage	NOUN
can-1683	158	11	of	of	ADP
can-1683	158	12	cardiovascular	cardiovascular	ADJ
can-1683	158	13	illness	illness	NOUN
can-1683	158	14	,	,	PUNCT
can-1683	158	15	and	and	CCONJ
can-1683	158	16	medications	medication	NOUN
can-1683	158	17	can	can	AUX
can-1683	158	18	be	be	AUX
can-1683	158	19	provided	provide	VERB
can-1683	158	20	after	after	SCONJ
can-1683	158	21	the	the	DET
can-1683	158	22	magnetic	magnetic	ADJ
can-1683	158	23	nanoparticles	nanoparticle	NOUN
can-1683	158	24	are	be	AUX
can-1683	158	25	infused	infuse	VERB
can-1683	158	26	in	in	ADP
can-1683	158	27	the	the	DET
can-1683	158	28	body	body	NOUN
can-1683	158	29	.	.	PUNCT
can-1683	159	1	diethylenetriamine	diethylenetriamine	PROPN
can-1683	159	2	pentaacetic	pentaacetic	PROPN
can-1683	159	3	acid	acid	PROPN
can-1683	159	4	(	(	PUNCT
can-1683	159	5	dtpa	dtpa	NOUN
can-1683	159	6	)	)	PUNCT
can-1683	159	7	was	be	AUX
can-1683	159	8	used[36	used[36	NOUN
can-1683	159	9	]	]	PUNCT
can-1683	159	10	to	to	PART
can-1683	159	11	chelate	chelate	VERB
can-1683	159	12	gadolinium	gadolinium	NOUN
can-1683	159	13	in	in	ADP
can-1683	159	14	hydrophilic	hydrophilic	ADJ
can-1683	159	15	lipid	lipid	NOUN
can-1683	159	16	(	(	PUNCT
can-1683	159	17	amphiphilic	amphiphilic	ADJ
can-1683	159	18	)	)	PUNCT
can-1683	159	19	micelles	micelle	NOUN
can-1683	159	20	,	,	PUNCT
can-1683	159	21	which	which	PRON
can-1683	159	22	were	be	AUX
can-1683	159	23	subsequently	subsequently	ADV
can-1683	159	24	encased	encased	ADJ
can-1683	159	25	in	in	ADP
can-1683	159	26	dendritic	dendritic	ADJ
can-1683	159	27	polymers	polymer	NOUN
can-1683	159	28	and	and	CCONJ
can-1683	159	29	linked	link	VERB
can-1683	159	30	with	with	ADP
can-1683	159	31	fibrin	fibrin	NOUN
can-1683	159	32	binding	bind	VERB
can-1683	159	33	agent	agent	NOUN
can-1683	159	34	.	.	PUNCT
can-1683	160	1	an	an	DET
can-1683	160	2	improved	improved	ADJ
can-1683	160	3	targeting	targeting	NOUN
can-1683	160	4	of	of	ADP
can-1683	160	5	atherosclerotic	atherosclerotic	ADJ
can-1683	160	6	plaques	plaque	NOUN
can-1683	160	7	and	and	CCONJ
can-1683	160	8	the	the	DET
can-1683	160	9	ability	ability	NOUN
can-1683	160	10	to	to	PART
can-1683	160	11	identify	identify	VERB
can-1683	160	12	thrombus	thrombus	NOUN
can-1683	160	13	at	at	ADP
can-1683	160	14	an	an	DET
can-1683	160	15	early	early	ADJ
can-1683	160	16	stage	stage	NOUN
can-1683	160	17	have	have	AUX
can-1683	160	18	been	be	AUX
can-1683	160	19	achieved	achieve	VERB
can-1683	160	20	by	by	ADP
can-1683	160	21	this	this	DET
can-1683	160	22	method	method	NOUN
can-1683	160	23	.	.	PUNCT
can-1683	161	1	new	new	PROPN
can-1683	161	2	zealand	zealand	PROPN
can-1683	161	3	white	white	PROPN
can-1683	161	4	rabbits	rabbit	NOUN
can-1683	161	5	were	be	AUX
can-1683	161	6	injected	inject	VERB
can-1683	161	7	intravenously	intravenously	ADV
can-1683	161	8	with	with	ADP
can-1683	161	9	paramagnetic	paramagnetic	ADJ
can-1683	161	10	nanoparticles	nanoparticle	NOUN
can-1683	161	11	targeting	target	VERB
can-1683	161	12	integrin	integrin	NOUN
can-1683	161	13	v3	v3	PROPN
can-1683	161	14	by	by	ADP
can-1683	161	15	winter	winter	PROPN
can-1683	161	16	et	et	PROPN
can-1683	161	17	al	al	PROPN
can-1683	161	18	.	.	PUNCT
can-1683	161	19	to	to	PART
can-1683	161	20	identify	identify	VERB
can-1683	161	21	neovascularization	neovascularization	NOUN
can-1683	161	22	in	in	ADP
can-1683	161	23	plaques	plaque	NOUN
can-1683	161	24	during	during	ADP
can-1683	161	25	the	the	DET
can-1683	161	26	early	early	ADJ
can-1683	161	27	stages	stage	NOUN
can-1683	161	28	of	of	ADP
can-1683	161	29	as[37	as[37	NOUN
can-1683	161	30	]	]	PUNCT
can-1683	161	31	.	.	PUNCT
can-1683	162	1	5.2	5.2	NUM
can-1683	162	2	x	x	NOUN
can-1683	162	3	-	-	NOUN
can-1683	162	4	ray	ray	NOUN
can-1683	162	5	imaging	imaging	NOUN
can-1683	162	6	nuclear	nuclear	ADJ
can-1683	162	7	medicine	medicine	NOUN
can-1683	162	8	relies	rely	VERB
can-1683	162	9	heavily	heavily	ADV
can-1683	162	10	on	on	ADP
can-1683	162	11	radionuclides	radionuclide	NOUN
can-1683	162	12	for	for	ADP
can-1683	162	13	imaging[38	imaging[38	NOUN
can-1683	162	14	]	]	X
can-1683	162	15	.	.	PUNCT
can-1683	163	1	in	in	ADP
can-1683	163	2	addition	addition	NOUN
can-1683	163	3	to	to	ADP
can-1683	163	4	being	be	AUX
can-1683	163	5	highly	highly	ADV
can-1683	163	6	sensitive	sensitive	ADJ
can-1683	163	7	,	,	PUNCT
can-1683	163	8	radionuclides	radionuclide	NOUN
can-1683	163	9	also	also	ADV
can-1683	163	10	have	have	VERB
can-1683	163	11	the	the	DET
can-1683	163	12	ability	ability	NOUN
can-1683	163	13	to	to	PART
can-1683	163	14	be	be	AUX
can-1683	163	15	quantified	quantify	VERB
can-1683	163	16	.	.	PUNCT
can-1683	164	1	imaging	imaging	NOUN
can-1683	164	2	techniques	technique	NOUN
can-1683	164	3	use	use	VERB
can-1683	164	4	positron	positron	NOUN
can-1683	164	5	emission	emission	NOUN
can-1683	164	6	tomography	tomography	NOUN
can-1683	164	7	(	(	PUNCT
can-1683	164	8	pet	pet	NOUN
can-1683	164	9	)	)	PUNCT
can-1683	164	10	and	and	CCONJ
can-1683	164	11	single	single	ADJ
can-1683	164	12	photon	photon	NOUN
can-1683	164	13	emittance	emittance	NOUN
can-1683	164	14	computed	compute	VERB
can-1683	164	15	tomography	tomography	NOUN
can-1683	164	16	(	(	PUNCT
can-1683	164	17	spect)[39	spect)[39	NOUN
can-1683	164	18	]	]	PUNCT
can-1683	164	19	.	.	PUNCT
can-1683	165	1	radiation	radiation	NOUN
can-1683	165	2	-	-	PUNCT
can-1683	165	3	labeled	label	VERB
can-1683	165	4	nanoparticles	nanoparticle	NOUN
can-1683	165	5	can	can	AUX
can-1683	165	6	now	now	ADV
can-1683	165	7	be	be	AUX
can-1683	165	8	used	use	VERB
can-1683	165	9	to	to	PART
can-1683	165	10	track	track	VERB
can-1683	165	11	the	the	DET
can-1683	165	12	embolization	embolization	NOUN
can-1683	165	13	process	process	NOUN
can-1683	165	14	and	and	CCONJ
can-1683	165	15	nanomedicine	nanomedicine	ADJ
can-1683	165	16	delivery	delivery	NOUN
can-1683	165	17	in	in	ADP
can-1683	165	18	order	order	NOUN
can-1683	165	19	to	to	PART
can-1683	165	20	gain	gain	VERB
can-1683	165	21	more	more	ADV
can-1683	165	22	precise	precise	ADJ
can-1683	165	23	imaging	imaging	NOUN
can-1683	165	24	.	.	PUNCT
can-1683	166	1	these	these	DET
can-1683	166	2	liposomes	liposome	NOUN
can-1683	166	3	were	be	AUX
can-1683	166	4	utilized	utilize	VERB
can-1683	166	5	to	to	PART
can-1683	166	6	conduct	conduct	VERB
can-1683	166	7	spect	spect	NOUN
can-1683	166	8	,	,	PUNCT
can-1683	166	9	which	which	PRON
can-1683	166	10	16	16	NUM
can-1683	166	11	can	can	AUX
can-1683	166	12	monitor	monitor	VERB
can-1683	166	13	the	the	DET
can-1683	166	14	distribution	distribution	NOUN
can-1683	166	15	of	of	ADP
can-1683	166	16	pharmaceuticals	pharmaceutical	NOUN
can-1683	166	17	in	in	ADP
can-1683	166	18	the	the	DET
can-1683	166	19	body	body	NOUN
can-1683	166	20	,	,	PUNCT
can-1683	166	21	as	as	ADV
can-1683	166	22	well	well	ADV
can-1683	166	23	as	as	ADP
can-1683	166	24	enhance	enhance	VERB
can-1683	166	25	drug	drug	NOUN
can-1683	166	26	release	release	NOUN
can-1683	166	27	.	.	PUNCT
can-1683	167	1	for	for	ADP
can-1683	167	2	example	example	NOUN
can-1683	167	3	,	,	PUNCT
can-1683	167	4	researchers	researcher	NOUN
can-1683	167	5	employed	employ	VERB
can-1683	167	6	186re	186re	ADJ
can-1683	167	7	-	-	PUNCT
can-1683	167	8	bmeda	bmeda	NOUN
can-1683	167	9	and	and	CCONJ
can-1683	167	10	99mtc	99mtc	NOUN
can-1683	167	11	-	-	PUNCT
can-1683	167	12	pegylate	pegylate	NOUN
can-1683	167	13	-	-	PUNCT
can-1683	167	14	labeled	label	VERB
can-1683	167	15	doxorubicin	doxorubicin	PROPN
can-1683	167	16	liposomes	liposome	NOUN
can-1683	167	17	.	.	PUNCT
can-1683	168	1	to	to	PART
can-1683	168	2	detect	detect	VERB
can-1683	168	3	atherosclerotic	atherosclerotic	ADJ
can-1683	168	4	plaques	plaque	NOUN
can-1683	168	5	,	,	PUNCT
can-1683	168	6	ct	ct	PROPN
can-1683	168	7	may	may	AUX
can-1683	168	8	be	be	AUX
can-1683	168	9	utilized	utilize	VERB
can-1683	168	10	to	to	PART
can-1683	168	11	detect	detect	VERB
can-1683	168	12	the	the	DET
can-1683	168	13	nanoparticles	nanoparticle	NOUN
can-1683	168	14	,	,	PUNCT
can-1683	168	15	which	which	PRON
can-1683	168	16	can	can	AUX
can-1683	168	17	also	also	ADV
can-1683	168	18	be	be	AUX
can-1683	168	19	used	use	VERB
can-1683	168	20	to	to	PART
can-1683	168	21	predict	predict	VERB
can-1683	168	22	the	the	DET
can-1683	168	23	prognosis	prognosis	NOUN
can-1683	168	24	of	of	ADP
can-1683	168	25	the	the	DET
can-1683	168	26	disease	disease	NOUN
can-1683	168	27	.	.	PUNCT
can-1683	169	1	using	use	VERB
can-1683	169	2	a	a	DET
can-1683	169	3	venous	venous	ADJ
can-1683	169	4	injection	injection	NOUN
can-1683	169	5	,	,	PUNCT
can-1683	169	6	galperin	galperin	NOUN
can-1683	169	7	and	and	CCONJ
can-1683	169	8	colleagues	colleague	NOUN
can-1683	169	9	administered	administer	VERB
can-1683	169	10	iodine	iodine	NOUN
can-1683	169	11	nanoparticle	nanoparticle	NOUN
can-1683	169	12	contrast	contrast	NOUN
can-1683	169	13	agent	agent	NOUN
can-1683	169	14	(	(	PUNCT
can-1683	169	15	n1177	n1177	NOUN
can-1683	169	16	)	)	PUNCT
can-1683	169	17	to	to	ADP
can-1683	169	18	animals	animal	NOUN
can-1683	169	19	.	.	PUNCT
can-1683	170	1	in	in	ADP
can-1683	170	2	macrophage	macrophage	ADJ
can-1683	170	3	-	-	PUNCT
can-1683	170	4	rich	rich	ADJ
can-1683	170	5	tissue	tissue	NOUN
can-1683	170	6	,	,	PUNCT
can-1683	170	7	the	the	DET
can-1683	170	8	contrast	contrast	NOUN
can-1683	170	9	agent	agent	NOUN
can-1683	170	10	was	be	AUX
can-1683	170	11	shown	show	VERB
can-1683	170	12	to	to	PART
can-1683	170	13	congregate	congregate	VERB
can-1683	170	14	,	,	PUNCT
can-1683	170	15	and	and	CCONJ
can-1683	170	16	the	the	DET
can-1683	170	17	signal	signal	NOUN
can-1683	170	18	of	of	ADP
can-1683	170	19	atherosclerotic	atherosclerotic	ADJ
can-1683	170	20	plaques	plaque	NOUN
can-1683	170	21	was	be	AUX
can-1683	170	22	greatly	greatly	ADV
can-1683	170	23	amplified	amplify	VERB
can-1683	170	24	,	,	PUNCT
can-1683	170	25	and	and	CCONJ
can-1683	170	26	the	the	DET
can-1683	170	27	enhancement	enhancement	NOUN
can-1683	170	28	period	period	NOUN
can-1683	170	29	may	may	AUX
can-1683	170	30	continue	continue	VERB
can-1683	170	31	for	for	ADP
can-1683	170	32	more	more	ADJ
can-1683	170	33	than	than	ADP
can-1683	170	34	30	30	NUM
can-1683	170	35	min	min	NOUN
can-1683	170	36	.	.	NOUN
can-1683	171	1	when	when	SCONJ
can-1683	171	2	researchers	researcher	NOUN
can-1683	171	3	utilized	utilize	VERB
can-1683	171	4	11	11	NUM
can-1683	171	5	-	-	PUNCT
can-1683	171	6	muda	muda	NOUN
can-1683	171	7	(	(	PUNCT
can-1683	171	8	11	11	NUM
can-1683	171	9	-	-	PUNCT
can-1683	171	10	mercaptoundecanoic	mercaptoundecanoic	NOUN
can-1683	171	11	acid	acid	NOUN
can-1683	171	12	)	)	PUNCT
can-1683	171	13	,	,	PUNCT
can-1683	171	14	they	they	PRON
can-1683	171	15	discovered	discover	VERB
can-1683	171	16	that	that	SCONJ
can-1683	171	17	gold	gold	ADJ
can-1683	171	18	nanoparticles	nanoparticle	NOUN
can-1683	171	19	might	might	AUX
can-1683	171	20	concentrate	concentrate	VERB
can-1683	171	21	in	in	ADP
can-1683	171	22	foam	foam	NOUN
can-1683	171	23	cells	cell	NOUN
can-1683	171	24	of	of	ADP
can-1683	171	25	atherosclerotic	atherosclerotic	ADJ
can-1683	171	26	plaques	plaque	NOUN
can-1683	171	27	and	and	CCONJ
can-1683	171	28	boost	boost	VERB
can-1683	171	29	the	the	DET
can-1683	171	30	contrast	contrast	NOUN
can-1683	171	31	of	of	ADP
can-1683	171	32	imaging[40	imaging[40	NOUN
can-1683	171	33	]	]	PUNCT
can-1683	171	34	.	.	PUNCT
can-1683	172	1	5.3	5.3	NUM
can-1683	172	2	fluorescence	fluorescence	NOUN
can-1683	172	3	imaging	imaging	NOUN
can-1683	172	4	optics	optic	NOUN
can-1683	172	5	is	be	AUX
can-1683	172	6	a	a	DET
can-1683	172	7	strong	strong	ADJ
can-1683	172	8	imaging	imaging	NOUN
can-1683	172	9	approach	approach	NOUN
can-1683	172	10	that	that	PRON
can-1683	172	11	has	have	VERB
can-1683	172	12	no	no	DET
can-1683	172	13	radiation	radiation	NOUN
can-1683	172	14	,	,	PUNCT
can-1683	172	15	no	no	DET
can-1683	172	16	invasion	invasion	NOUN
can-1683	172	17	,	,	PUNCT
can-1683	172	18	great	great	ADJ
can-1683	172	19	resolution	resolution	NOUN
can-1683	172	20	and	and	CCONJ
can-1683	172	21	good	good	ADJ
can-1683	172	22	controllability	controllability	NOUN
can-1683	172	23	,	,	PUNCT
can-1683	172	24	but	but	CCONJ
can-1683	172	25	it	it	PRON
can-1683	172	26	has	have	VERB
can-1683	172	27	a	a	DET
can-1683	172	28	low	low	ADJ
can-1683	172	29	penetrating	penetrating	NOUN
can-1683	172	30	ability	ability	NOUN
can-1683	172	31	.	.	PUNCT
can-1683	173	1	fluorescein	fluorescein	NOUN
can-1683	173	2	is	be	AUX
can-1683	173	3	commonly	commonly	ADV
can-1683	173	4	used	use	VERB
can-1683	173	5	to	to	PART
can-1683	173	6	create	create	VERB
can-1683	173	7	fluorescence	fluorescence	NOUN
can-1683	173	8	signals	signal	NOUN
can-1683	173	9	in	in	ADP
can-1683	173	10	fluorescence	fluorescence	NOUN
can-1683	173	11	imaging	imaging	NOUN
can-1683	173	12	.	.	PUNCT
can-1683	174	1	it	it	PRON
can-1683	174	2	is	be	AUX
can-1683	174	3	common	common	ADJ
can-1683	174	4	to	to	PART
can-1683	174	5	utilize	utilize	VERB
can-1683	174	6	near	near	ADP
can-1683	174	7	infrared	infrared	ADJ
can-1683	174	8	fluorescence	fluorescence	NOUN
can-1683	174	9	(	(	PUNCT
can-1683	174	10	nirf	nirf	NOUN
can-1683	174	11	)	)	PUNCT
can-1683	174	12	probes	probe	NOUN
can-1683	174	13	due	due	ADJ
can-1683	174	14	to	to	ADP
can-1683	174	15	their	their	PRON
can-1683	174	16	high	high	ADJ
can-1683	174	17	penetrating	penetrating	NOUN
can-1683	174	18	power	power	NOUN
can-1683	174	19	and	and	CCONJ
can-1683	174	20	safety	safety	NOUN
can-1683	174	21	.	.	PUNCT
can-1683	175	1	small	small	ADJ
can-1683	175	2	animal	animal	NOUN
can-1683	175	3	live	live	ADJ
can-1683	175	4	imaging	imaging	NOUN
can-1683	175	5	systems	system	NOUN
can-1683	175	6	and	and	CCONJ
can-1683	175	7	clinical	clinical	ADJ
can-1683	175	8	tumor	tumor	NOUN
can-1683	175	9	transformation	transformation	NOUN
can-1683	175	10	have	have	AUX
can-1683	175	11	utilized	utilize	VERB
can-1683	175	12	them	they	PRON
can-1683	175	13	.	.	PUNCT
can-1683	176	1	nano	nano	NOUN
can-1683	176	2	-	-	PUNCT
can-1683	176	3	drug	drug	NOUN
can-1683	176	4	carriers	carrier	NOUN
can-1683	176	5	,	,	PUNCT
can-1683	176	6	such	such	ADJ
can-1683	176	7	as	as	ADP
can-1683	176	8	liposomes	liposome	NOUN
can-1683	176	9	,	,	PUNCT
can-1683	176	10	metal	metal	NOUN
can-1683	176	11	,	,	PUNCT
can-1683	176	12	or	or	CCONJ
can-1683	176	13	non	non	ADJ
can-1683	176	14	-	-	ADJ
can-1683	176	15	metallic	metallic	ADJ
can-1683	176	16	nanoparticles	nanoparticle	NOUN
can-1683	176	17	,	,	PUNCT
can-1683	176	18	can	can	AUX
can-1683	176	19	encapsulate	encapsulate	VERB
can-1683	176	20	nirf	nirf	NOUN
can-1683	176	21	to	to	PART
can-1683	176	22	enable	enable	VERB
can-1683	176	23	optical	optical	ADJ
can-1683	176	24	imaging	imaging	NOUN
can-1683	176	25	of	of	ADP
can-1683	176	26	blood	blood	NOUN
can-1683	176	27	arteries	artery	NOUN
can-1683	176	28	at	at	ADP
can-1683	176	29	present	present	ADJ
can-1683	176	30	.	.	PUNCT
can-1683	177	1	a	a	DET
can-1683	177	2	growing	grow	VERB
can-1683	177	3	amount	amount	NOUN
can-1683	177	4	of	of	ADP
can-1683	177	5	focus	focus	NOUN
can-1683	177	6	has	have	AUX
can-1683	177	7	been	be	AUX
can-1683	177	8	placed	place	VERB
can-1683	177	9	on	on	ADP
can-1683	177	10	its	its	PRON
can-1683	177	11	use	use	NOUN
can-1683	177	12	in	in	ADP
can-1683	177	13	cardiovascular	cardiovascular	ADJ
can-1683	177	14	disease	disease	NOUN
can-1683	177	15	imaging	imaging	NOUN
can-1683	177	16	.	.	PUNCT
can-1683	178	1	they	they	PRON
can-1683	178	2	created	create	VERB
can-1683	178	3	diagnostic	diagnostic	ADJ
can-1683	178	4	and	and	CCONJ
can-1683	178	5	therapeutic	therapeutic	ADJ
can-1683	178	6	nanoparticles	nanoparticle	NOUN
can-1683	178	7	by	by	ADP
can-1683	178	8	combining	combine	VERB
can-1683	178	9	near	near	ADP
can-1683	178	10	infrared	infrared	ADJ
can-1683	178	11	light	light	NOUN
can-1683	178	12	activated	activate	VERB
can-1683	178	13	therapy	therapy	NOUN
can-1683	178	14	(	(	PUNCT
can-1683	178	15	nilat	nilat	NOUN
can-1683	178	16	)	)	PUNCT
can-1683	178	17	with	with	ADP
can-1683	178	18	macrophage	macrophage	ADJ
can-1683	178	19	-	-	PUNCT
can-1683	178	20	targeted	target	VERB
can-1683	178	21	magnetic	magnetic	ADJ
can-1683	178	22	nanoparticles	nanoparticle	NOUN
can-1683	178	23	(	(	PUNCT
can-1683	178	24	mnp	mnp	PROPN
can-1683	178	25	)	)	PUNCT
can-1683	178	26	.	.	PUNCT
can-1683	179	1	within	within	ADP
can-1683	179	2	24	24	NUM
can-1683	179	3	hours	hour	NOUN
can-1683	179	4	of	of	ADP
can-1683	179	5	injection	injection	NOUN
can-1683	179	6	,	,	PUNCT
can-1683	179	7	the	the	DET
can-1683	179	8	nanoparticles	nanoparticle	NOUN
can-1683	179	9	had	have	AUX
can-1683	179	10	spread	spread	VERB
can-1683	179	11	across	across	ADP
can-1683	179	12	the	the	DET
can-1683	179	13	study	study	NOUN
can-1683	179	14	region	region	NOUN
can-1683	179	15	.	.	PUNCT
can-1683	180	1	using	use	VERB
can-1683	180	2	profilin-1	profilin-1	PROPN
can-1683	180	3	as	as	ADP
can-1683	180	4	a	a	DET
can-1683	180	5	target[41	target[41	PROPN
can-1683	180	6	]	]	PUNCT
can-1683	180	7	injected	inject	VERB
can-1683	180	8	atherosclerotic	atherosclerotic	ADJ
can-1683	180	9	mice	mouse	NOUN
can-1683	180	10	with	with	ADP
can-1683	180	11	profilin-1	profilin-1	NOUN
can-1683	180	12	-	-	PUNCT
can-1683	180	13	targeting	target	VERB
can-1683	180	14	magnetic	magnetic	ADJ
can-1683	180	15	iron	iron	NOUN
can-1683	180	16	oxide	oxide	NOUN
can-1683	180	17	nanoparticles	nanoparticle	NOUN
can-1683	180	18	(	(	PUNCT
can-1683	180	19	pf1cy5.5	pf1cy5.5	NOUN
can-1683	180	20	-	-	PUNCT
can-1683	180	21	dmsa	dmsa	NOUN
can-1683	180	22	-	-	PUNCT
can-1683	180	23	fe3	fe3	NOUN
can-1683	180	24	o4	o4	PROPN
can-1683	180	25	nps	nps	PROPN
can-1683	180	26	)	)	PUNCT
can-1683	180	27	.	.	PUNCT
can-1683	181	1	carotid	carotid	NOUN
can-1683	181	2	atherosclerotic	atherosclerotic	ADJ
can-1683	181	3	plaques	plaque	NOUN
can-1683	181	4	contained	contain	VERB
can-1683	181	5	magnetic	magnetic	ADJ
can-1683	181	6	iron	iron	NOUN
can-1683	181	7	oxide	oxide	NOUN
can-1683	181	8	nanoparticle	nanoparticle	NOUN
can-1683	181	9	aggregates	aggregate	NOUN
can-1683	181	10	.	.	PUNCT
can-1683	182	1	fluorescence	fluorescence	NOUN
can-1683	182	2	intensity	intensity	NOUN
can-1683	182	3	measured	measure	VERB
can-1683	182	4	in	in	ADP
can-1683	182	5	vitro	vitro	X
can-1683	182	6	was	be	AUX
can-1683	182	7	found	find	VERB
can-1683	182	8	to	to	PART
can-1683	182	9	be	be	AUX
can-1683	182	10	in	in	ADP
can-1683	182	11	good	good	ADJ
can-1683	182	12	agreement	agreement	NOUN
can-1683	182	13	with	with	ADP
can-1683	182	14	the	the	DET
can-1683	182	15	mri	mri	NOUN
can-1683	182	16	signal	signal	NOUN
can-1683	182	17	from	from	ADP
can-1683	182	18	animals	animal	NOUN
can-1683	182	19	injected	inject	VERB
can-1683	182	20	with	with	ADP
can-1683	182	21	pc	pc	NOUN
can-1683	182	22	-	-	PUNCT
can-1683	182	23	nps	nps	PROPN
can-1683	182	24	.	.	PROPN
can-1683	183	1	5.4	5.4	NUM
can-1683	183	2	ultrasound	ultrasound	NOUN
can-1683	183	3	imaging	imaging	NOUN
can-1683	183	4	ultrasound	ultrasound	PROPN
can-1683	183	5	imaging	imaging	NOUN
can-1683	183	6	provides	provide	VERB
can-1683	183	7	a	a	DET
can-1683	183	8	number	number	NOUN
can-1683	183	9	of	of	ADP
can-1683	183	10	advantages	advantage	NOUN
can-1683	183	11	to	to	ADP
can-1683	183	12	fluorescence	fluorescence	NOUN
can-1683	183	13	imaging	imaging	NOUN
can-1683	183	14	,	,	PUNCT
can-1683	183	15	including	include	VERB
can-1683	183	16	the	the	DET
can-1683	183	17	fact	fact	NOUN
can-1683	183	18	that	that	SCONJ
can-1683	183	19	it	it	PRON
can-1683	183	20	is	be	AUX
can-1683	183	21	less	less	ADV
can-1683	183	22	invasive	invasive	ADJ
can-1683	183	23	,	,	PUNCT
can-1683	183	24	more	more	ADV
can-1683	183	25	convenient	convenient	ADJ
can-1683	183	26	,	,	PUNCT
can-1683	183	27	and	and	CCONJ
can-1683	183	28	can	can	AUX
can-1683	183	29	be	be	AUX
can-1683	183	30	used	use	VERB
can-1683	183	31	in	in	ADP
can-1683	183	32	real	real	ADJ
can-1683	183	33	time	time	NOUN
can-1683	183	34	.	.	PUNCT
can-1683	184	1	materials	material	NOUN
can-1683	184	2	that	that	PRON
can-1683	184	3	can	can	AUX
can-1683	184	4	be	be	AUX
can-1683	184	5	targeted	target	VERB
can-1683	184	6	to	to	ADP
can-1683	184	7	certain	certain	ADJ
can-1683	184	8	vascular	vascular	ADJ
can-1683	184	9	indicators	indicator	NOUN
can-1683	184	10	have	have	AUX
can-1683	184	11	been	be	AUX
can-1683	184	12	produced	produce	VERB
can-1683	184	13	.	.	PUNCT
can-1683	185	1	to	to	PART
can-1683	185	2	give	give	VERB
can-1683	185	3	one	one	NUM
can-1683	185	4	example	example	NOUN
can-1683	185	5	,	,	PUNCT
can-1683	185	6	vascular	vascular	ADJ
can-1683	185	7	ultrasound	ultrasound	NOUN
can-1683	185	8	nanoparticles	nanoparticle	NOUN
can-1683	185	9	that	that	PRON
can-1683	185	10	target	target	VERB
can-1683	185	11	vegfr2	vegfr2	NOUN
can-1683	185	12	increase	increase	NOUN
can-1683	185	13	drug	drug	NOUN
can-1683	185	14	localization	localization	NOUN
can-1683	185	15	in	in	ADP
can-1683	185	16	blood	blood	NOUN
can-1683	185	17	vessels	vessel	NOUN
can-1683	185	18	by	by	ADP
can-1683	185	19	increasing	increase	VERB
can-1683	185	20	the	the	DET
can-1683	185	21	clarity	clarity	NOUN
can-1683	185	22	of	of	ADP
can-1683	185	23	ultrasound	ultrasound	ADJ
can-1683	185	24	imaging	imaging	NOUN
can-1683	185	25	of	of	ADP
can-1683	185	26	tumor	tumor	NOUN
can-1683	185	27	blood	blood	NOUN
can-1683	185	28	vessels	vessel	NOUN
can-1683	185	29	.	.	PUNCT
can-1683	186	1	vegfr2	vegfr2	NOUN
can-1683	186	2	is	be	AUX
can-1683	186	3	an	an	DET
can-1683	186	4	endothelial	endothelial	ADJ
can-1683	186	5	growth	growth	NOUN
can-1683	186	6	factor	factor	NOUN
can-1683	186	7	receptor	receptor	NOUN
can-1683	186	8	2	2	NUM
can-1683	186	9	(	(	PUNCT
can-1683	186	10	vegfr2	vegfr2	NOUN
can-1683	186	11	)	)	PUNCT
can-1683	186	12	.	.	PUNCT
can-1683	187	1	streptokinase	streptokinase	PROPN
can-1683	187	2	-	-	PUNCT
can-1683	187	3	carrying	carry	VERB
can-1683	187	4	perfluorocarbon	perfluorocarbon	NOUN
can-1683	187	5	nanoparticles	nanoparticle	NOUN
can-1683	187	6	were	be	AUX
can-1683	187	7	created	create	VERB
can-1683	187	8	by	by	ADP
can-1683	187	9	marsh	marsh	PROPN
can-1683	187	10	and	and	CCONJ
can-1683	187	11	colleagues	colleague	NOUN
can-1683	187	12	for	for	ADP
can-1683	187	13	the	the	DET
can-1683	187	14	diagnosis	diagnosis	NOUN
can-1683	187	15	and	and	CCONJ
can-1683	187	16	treatment	treatment	NOUN
can-1683	187	17	of	of	ADP
can-1683	187	18	thrombus[42	thrombus[42	NOUN
can-1683	187	19	]	]	PUNCT
can-1683	187	20	.	.	PUNCT
can-1683	188	1	ultrasonic	ultrasonic	ADJ
can-1683	188	2	imaging	imaging	NOUN
can-1683	188	3	may	may	AUX
can-1683	188	4	be	be	AUX
can-1683	188	5	performed	perform	VERB
can-1683	188	6	on	on	ADP
can-1683	188	7	the	the	DET
can-1683	188	8	drug	drug	NOUN
can-1683	188	9	-	-	PUNCT
can-1683	188	10	loaded	load	VERB
can-1683	188	11	particles	particle	NOUN
can-1683	188	12	,	,	PUNCT
can-1683	188	13	which	which	PRON
can-1683	188	14	are	be	AUX
can-1683	188	15	made	make	VERB
can-1683	188	16	using	use	VERB
can-1683	188	17	the	the	DET
can-1683	188	18	evaporation	evaporation	NOUN
can-1683	188	19	/	/	SYM
can-1683	188	20	dispersion	dispersion	NOUN
can-1683	188	21	approach	approach	NOUN
can-1683	188	22	and	and	CCONJ
can-1683	188	23	have	have	VERB
can-1683	188	24	a	a	DET
can-1683	188	25	diameter	diameter	NOUN
can-1683	188	26	of	of	ADP
can-1683	188	27	around	around	ADP
can-1683	188	28	250	250	NUM
can-1683	188	29	nm	nm	NOUN
can-1683	188	30	.	.	PUNCT
can-1683	189	1	5.5	5.5	NUM
can-1683	189	2	multi	multi	ADJ
can-1683	189	3	-	-	ADJ
can-1683	189	4	modal	modal	ADJ
can-1683	189	5	bioimaging	bioimaging	NOUN
can-1683	189	6	a	a	DET
can-1683	189	7	mixture	mixture	NOUN
can-1683	189	8	of	of	ADP
can-1683	189	9	diverse	diverse	ADJ
can-1683	189	10	imaging	imaging	NOUN
can-1683	189	11	technologies	technology	NOUN
can-1683	189	12	,	,	PUNCT
can-1683	189	13	known	know	VERB
can-1683	189	14	as	as	ADP
can-1683	189	15	multi	multi	ADJ
can-1683	189	16	-	-	ADJ
can-1683	189	17	modal	modal	ADJ
can-1683	189	18	imaging	imaging	NOUN
can-1683	189	19	technology	technology	NOUN
can-1683	189	20	,	,	PUNCT
can-1683	189	21	may	may	AUX
can-1683	189	22	now	now	ADV
can-1683	189	23	be	be	AUX
can-1683	189	24	used	use	VERB
can-1683	189	25	to	to	PART
can-1683	189	26	achieve	achieve	VERB
can-1683	189	27	synergistic	synergistic	ADJ
can-1683	189	28	effects	effect	NOUN
can-1683	189	29	,	,	PUNCT
can-1683	189	30	resulting	result	VERB
can-1683	189	31	in	in	ADP
can-1683	189	32	more	more	ADV
can-1683	189	33	complete	complete	ADJ
can-1683	189	34	and	and	CCONJ
can-1683	189	35	accurate	accurate	ADJ
can-1683	189	36	images	image	NOUN
can-1683	189	37	for	for	ADP
can-1683	189	38	the	the	DET
can-1683	189	39	diagnosis	diagnosis	NOUN
can-1683	189	40	and	and	CCONJ
can-1683	189	41	treatment	treatment	NOUN
can-1683	189	42	of	of	ADP
can-1683	189	43	cardiovascular	cardiovascular	ADJ
can-1683	189	44	diseases	disease	NOUN
can-1683	189	45	.	.	PUNCT
can-1683	190	1	for	for	ADP
can-1683	190	2	example	example	NOUN
can-1683	190	3	,	,	PUNCT
can-1683	190	4	64cu	64cu	ADV
can-1683	190	5	-	-	PUNCT
can-1683	190	6	labeled	label	VERB
can-1683	190	7	spio	spio	NOUN
can-1683	190	8	-	-	PUNCT
can-1683	190	9	loaded	load	VERB
can-1683	190	10	doxorubicin	doxorubicin	PROPN
can-1683	190	11	nanoparticles	nanoparticle	NOUN
can-1683	190	12	can	can	AUX
can-1683	190	13	be	be	AUX
can-1683	190	14	employed	employ	VERB
can-1683	190	15	for	for	ADP
can-1683	190	16	mri	mri	NOUN
can-1683	190	17	and	and	CCONJ
can-1683	190	18	pet	pet	ADJ
can-1683	190	19	imaging	imaging	NOUN
can-1683	190	20	,	,	PUNCT
can-1683	190	21	for	for	ADP
can-1683	190	22	example[43	example[43	NOUN
can-1683	190	23	]	]	PUNCT
can-1683	190	24	.	.	PUNCT
can-1683	191	1	according	accord	VERB
can-1683	191	2	to	to	ADP
can-1683	191	3	one	one	NUM
can-1683	191	4	study	study	NOUN
can-1683	191	5	,	,	PUNCT
can-1683	191	6	gold	gold	NOUN
can-1683	191	7	nanoparticles	nanoparticle	NOUN
can-1683	191	8	mixed	mix	VERB
can-1683	191	9	with	with	ADP
can-1683	191	10	cy5	cy5	NOUN
can-1683	191	11	,	,	PUNCT
can-1683	191	12	sputum	sputum	NOUN
can-1683	191	13	,	,	PUNCT
can-1683	191	14	and	and	CCONJ
can-1683	191	15	folic	folic	NOUN
can-1683	191	16	acid	acid	NOUN
can-1683	191	17	can	can	AUX
can-1683	191	18	provide	provide	VERB
can-1683	191	19	trimodal	trimodal	NOUN
can-1683	191	20	optical	optical	ADJ
can-1683	191	21	imaging	imaging	NOUN
can-1683	191	22	as	as	ADV
can-1683	191	23	well	well	ADV
can-1683	191	24	as	as	ADP
can-1683	191	25	mri	mri	NOUN
can-1683	191	26	and	and	CCONJ
can-1683	191	27	ct	ct	PROPN
can-1683	191	28	imaging	imaging	NOUN
can-1683	191	29	in	in	ADP
can-1683	191	30	mice[44	mice[44	NOUN
can-1683	191	31	]	]	PUNCT
can-1683	191	32	.	.	PUNCT
can-1683	192	1	cardiovascular	cardiovascular	ADJ
can-1683	192	2	nanomedicine	nanomedicine	PROPN
can-1683	192	3	’s	’s	PART
can-1683	192	4	future	future	ADJ
can-1683	192	5	development	development	NOUN
can-1683	192	6	will	will	AUX
can-1683	192	7	take	take	VERB
can-1683	192	8	a	a	DET
can-1683	192	9	fresh	fresh	ADJ
can-1683	192	10	turn	turn	NOUN
can-1683	192	11	in	in	ADP
can-1683	192	12	the	the	DET
can-1683	192	13	direction	direction	NOUN
can-1683	192	14	of	of	ADP
can-1683	192	15	multimodal	multimodal	NOUN
can-1683	192	16	imaging	imaging	NOUN
can-1683	192	17	and	and	CCONJ
can-1683	192	18	diagnostic	diagnostic	ADJ
can-1683	192	19	and	and	CCONJ
can-1683	192	20	therapy	therapy	NOUN
can-1683	192	21	integration	integration	NOUN
can-1683	192	22	.	.	PUNCT
can-1683	193	1	6	6	X
can-1683	193	2	.	.	X
can-1683	193	3	application	application	NOUN
can-1683	193	4	of	of	ADP
can-1683	193	5	the	the	DET
can-1683	193	6	nddss	nddss	NOUN
can-1683	193	7	in	in	ADP
can-1683	193	8	the	the	DET
can-1683	193	9	treatment	treatment	NOUN
can-1683	193	10	of	of	ADP
can-1683	193	11	cvds	cvds	PROPN
can-1683	193	12	6.1	6.1	NUM
can-1683	193	13	the	the	DET
can-1683	193	14	nddss	nddss	NOUN
can-1683	193	15	in	in	ADV
can-1683	193	16	as	as	SCONJ
can-1683	193	17	as	as	SCONJ
can-1683	193	18	is	be	AUX
can-1683	193	19	the	the	DET
can-1683	193	20	most	most	ADV
can-1683	193	21	prevalent	prevalent	ADJ
can-1683	193	22	kind	kind	NOUN
can-1683	193	23	of	of	ADP
can-1683	193	24	cvd	cvd	PROPN
can-1683	193	25	,	,	PUNCT
can-1683	193	26	and	and	CCONJ
can-1683	193	27	it	it	PRON
can-1683	193	28	frequently	frequently	ADV
can-1683	193	29	results	result	VERB
can-1683	193	30	in	in	ADP
can-1683	193	31	a	a	DET
can-1683	193	32	stroke	stroke	NOUN
can-1683	193	33	or	or	CCONJ
can-1683	193	34	heart	heart	NOUN
can-1683	193	35	attack	attack	NOUN
can-1683	193	36	.	.	PUNCT
can-1683	194	1	endothelial	endothelial	ADJ
can-1683	194	2	dysfunction	dysfunction	NOUN
can-1683	194	3	is	be	AUX
can-1683	194	4	the	the	DET
can-1683	194	5	first	first	ADJ
can-1683	194	6	step	step	NOUN
can-1683	194	7	in	in	ADP
can-1683	194	8	the	the	DET
can-1683	194	9	development	development	NOUN
can-1683	194	10	of	of	ADP
can-1683	194	11	as	as	ADP
can-1683	194	12	.	.	PUNCT
can-1683	195	1	ischemic	ischemic	ADJ
can-1683	195	2	cardiomyopathy	cardiomyopathy	ADJ
can-1683	195	3	can	can	AUX
can-1683	195	4	be	be	AUX
can-1683	195	5	caused	cause	VERB
can-1683	195	6	by	by	ADP
can-1683	195	7	plaque	plaque	NOUN
can-1683	195	8	-	-	PUNCT
can-1683	195	9	induced	induce	VERB
can-1683	195	10	coronary	coronary	ADJ
can-1683	195	11	artery	artery	NOUN
can-1683	195	12	narrowing	narrow	VERB
can-1683	195	13	,	,	PUNCT
can-1683	195	14	whereas	whereas	SCONJ
can-1683	195	15	acute	acute	ADJ
can-1683	195	16	myocardial	myocardial	ADJ
can-1683	195	17	infarction	infarction	NOUN
can-1683	195	18	might	might	AUX
can-1683	195	19	be	be	AUX
can-1683	195	20	17	17	NUM
can-1683	195	21	caused	cause	VERB
can-1683	195	22	by	by	ADP
can-1683	195	23	plaque	plaque	NOUN
can-1683	195	24	rupture	rupture	NOUN
can-1683	195	25	.	.	PUNCT
can-1683	196	1	peptideases	peptidease	NOUN
can-1683	196	2	and	and	CCONJ
can-1683	196	3	macrophages	macrophage	NOUN
can-1683	196	4	can	can	AUX
can-1683	196	5	be	be	AUX
can-1683	196	6	candidates	candidate	NOUN
can-1683	196	7	for	for	ADP
can-1683	196	8	intervention	intervention	NOUN
can-1683	196	9	in	in	ADP
can-1683	196	10	the	the	DET
can-1683	196	11	pathophysiology	pathophysiology	NOUN
can-1683	196	12	of	of	ADP
can-1683	196	13	plaque	plaque	NOUN
can-1683	196	14	instability	instability	NOUN
can-1683	196	15	because	because	SCONJ
can-1683	196	16	of	of	ADP
can-1683	196	17	increased	increase	VERB
can-1683	196	18	vascular	vascular	ADJ
can-1683	196	19	permeability	permeability	NOUN
can-1683	196	20	,	,	PUNCT
can-1683	196	21	increased	increase	VERB
can-1683	196	22	pecam	pecam	NOUN
can-1683	196	23	expression	expression	NOUN
can-1683	196	24	,	,	PUNCT
can-1683	196	25	and	and	CCONJ
can-1683	196	26	macrophage	macrophage	ADJ
can-1683	196	27	aggregation	aggregation	NOUN
can-1683	196	28	.	.	PUNCT
can-1683	197	1	in	in	ADP
can-1683	197	2	order	order	NOUN
can-1683	197	3	to	to	PART
can-1683	197	4	maximize	maximize	VERB
can-1683	197	5	the	the	DET
can-1683	197	6	concentration	concentration	NOUN
can-1683	197	7	of	of	ADP
can-1683	197	8	lesions	lesion	NOUN
can-1683	197	9	and	and	CCONJ
can-1683	197	10	decrease	decrease	VERB
can-1683	197	11	side	side	ADJ
can-1683	197	12	effects	effect	NOUN
can-1683	197	13	,	,	PUNCT
can-1683	197	14	the	the	DET
can-1683	197	15	medicine	medicine	NOUN
can-1683	197	16	can	can	AUX
can-1683	197	17	be	be	AUX
can-1683	197	18	administered	administer	VERB
can-1683	197	19	to	to	ADP
can-1683	197	20	atherosclerotic	atherosclerotic	ADJ
can-1683	197	21	plaques	plaque	NOUN
can-1683	197	22	using	use	VERB
can-1683	197	23	a	a	DET
can-1683	197	24	nano	nano	NOUN
can-1683	197	25	-	-	PUNCT
can-1683	197	26	drug	drug	NOUN
can-1683	197	27	carrier	carrier	NOUN
can-1683	197	28	.	.	PUNCT
can-1683	198	1	with	with	ADP
can-1683	198	2	these	these	DET
can-1683	198	3	nano	nano	NOUN
can-1683	198	4	-	-	PUNCT
can-1683	198	5	drug	drug	NOUN
can-1683	198	6	carriers	carrier	NOUN
can-1683	198	7	,	,	PUNCT
can-1683	198	8	you	you	PRON
can-1683	198	9	can	can	AUX
can-1683	198	10	regulate	regulate	VERB
can-1683	198	11	lipoprotein	lipoprotein	ADJ
can-1683	198	12	levels	level	NOUN
can-1683	198	13	and	and	CCONJ
can-1683	198	14	reduce	reduce	VERB
can-1683	198	15	inflammation	inflammation	NOUN
can-1683	198	16	as	as	ADV
can-1683	198	17	well	well	ADV
can-1683	198	18	as	as	ADP
can-1683	198	19	prevent	prevent	VERB
can-1683	198	20	the	the	DET
can-1683	198	21	formation	formation	NOUN
can-1683	198	22	of	of	ADP
can-1683	198	23	new	new	ADJ
can-1683	198	24	vessels	vessel	NOUN
can-1683	198	25	.	.	PUNCT
can-1683	199	1	in	in	ADP
can-1683	199	2	order	order	NOUN
can-1683	199	3	to	to	PART
can-1683	199	4	stop	stop	VERB
can-1683	199	5	the	the	DET
can-1683	199	6	formation	formation	NOUN
can-1683	199	7	of	of	ADP
can-1683	199	8	as	as	ADP
can-1683	199	9	,	,	PUNCT
can-1683	199	10	reduce	reduce	VERB
can-1683	199	11	plaque	plaque	NOUN
can-1683	199	12	area	area	NOUN
can-1683	199	13	,	,	PUNCT
can-1683	199	14	or	or	CCONJ
can-1683	199	15	stabilize	stabilize	VERB
can-1683	199	16	susceptible	susceptible	ADJ
can-1683	199	17	plaques	plaque	NOUN
can-1683	199	18	,	,	PUNCT
can-1683	199	19	these	these	DET
can-1683	199	20	therapeutic	therapeutic	ADJ
can-1683	199	21	options	option	NOUN
can-1683	199	22	are	be	AUX
can-1683	199	23	employed[45	employed[45	ADV
can-1683	199	24	]	]	PUNCT
can-1683	199	25	.	.	PUNCT
can-1683	200	1	6.2	6.2	NUM
can-1683	200	2	the	the	DET
can-1683	200	3	nddss	nddss	NOUN
can-1683	200	4	in	in	ADP
can-1683	200	5	hypertension	hypertension	NOUN
can-1683	200	6	today	today	NOUN
can-1683	200	7	,	,	PUNCT
can-1683	200	8	a	a	DET
can-1683	200	9	wide	wide	ADJ
can-1683	200	10	variety	variety	NOUN
can-1683	200	11	of	of	ADP
can-1683	200	12	medications	medication	NOUN
can-1683	200	13	are	be	AUX
can-1683	200	14	used	use	VERB
can-1683	200	15	to	to	PART
can-1683	200	16	treat	treat	VERB
can-1683	200	17	hypertension	hypertension	NOUN
can-1683	200	18	,	,	PUNCT
can-1683	200	19	including	include	VERB
can-1683	200	20	aten	aten	ADJ
can-1683	200	21	inhibitors	inhibitor	NOUN
can-1683	200	22	,	,	PUNCT
can-1683	200	23	vascular	vascular	ADJ
can-1683	200	24	angiotensin	angiotensin	NOUN
can-1683	200	25	antagonists	antagonist	NOUN
can-1683	200	26	,	,	PUNCT
can-1683	200	27	central	central	ADJ
can-1683	200	28	sympathetic	sympathetic	ADJ
can-1683	200	29	nerve	nerve	NOUN
can-1683	200	30	agents	agent	NOUN
can-1683	200	31	,	,	PUNCT
can-1683	200	32	adrenergic	adrenergic	ADJ
can-1683	200	33	receptor	receptor	NOUN
can-1683	200	34	blockers	blocker	NOUN
can-1683	200	35	,	,	PUNCT
can-1683	200	36	diuretics	diuretic	NOUN
can-1683	200	37	and	and	CCONJ
can-1683	200	38	vasodilators	vasodilator	NOUN
can-1683	200	39	,	,	PUNCT
can-1683	200	40	among	among	ADP
can-1683	200	41	other	other	ADJ
can-1683	200	42	classes	class	NOUN
can-1683	200	43	of	of	ADP
can-1683	200	44	medication[46	medication[46	PROPN
can-1683	200	45	]	]	PUNCT
can-1683	200	46	.	.	PUNCT
can-1683	201	1	antihypertensive	antihypertensive	ADJ
can-1683	201	2	therapeutic	therapeutic	ADJ
can-1683	201	3	medications	medication	NOUN
can-1683	201	4	have	have	VERB
can-1683	201	5	evident	evident	ADJ
can-1683	201	6	flaws	flaw	NOUN
can-1683	201	7	such	such	ADJ
can-1683	201	8	as	as	ADP
can-1683	201	9	short	short	ADJ
can-1683	201	10	plasma	plasma	NOUN
can-1683	201	11	half	half	NOUN
can-1683	201	12	-	-	PUNCT
can-1683	201	13	lives	life	NOUN
can-1683	201	14	,	,	PUNCT
can-1683	201	15	limited	limited	ADJ
can-1683	201	16	bioavailability	bioavailability	NOUN
can-1683	201	17	and	and	CCONJ
can-1683	201	18	toxic	toxic	ADJ
can-1683	201	19	and	and	CCONJ
can-1683	201	20	side	side	NOUN
can-1683	201	21	effects	effect	NOUN
can-1683	201	22	such	such	ADJ
can-1683	201	23	as	as	ADP
can-1683	201	24	upper	upper	ADJ
can-1683	201	25	respiratory	respiratory	ADJ
can-1683	201	26	tract	tract	NOUN
can-1683	201	27	abstraction	abstraction	NOUN
can-1683	201	28	,	,	PUNCT
can-1683	201	29	angioedema	angioedema	ADV
can-1683	201	30	,	,	PUNCT
can-1683	201	31	reflex	reflex	ADJ
can-1683	201	32	thyrotomy	thyrotomy	NOUN
can-1683	201	33	,	,	PUNCT
can-1683	201	34	excessive	excessive	ADJ
can-1683	201	35	hypotensive	hypotensive	ADJ
can-1683	201	36	effects	effect	NOUN
can-1683	201	37	,	,	PUNCT
can-1683	201	38	etc	etc	X
can-1683	201	39	.	.	X
can-1683	201	40	nano	nano	NOUN
can-1683	201	41	-	-	PUNCT
can-1683	201	42	drug	drug	NOUN
can-1683	201	43	carriers	carrier	NOUN
can-1683	201	44	,	,	PUNCT
can-1683	201	45	on	on	ADP
can-1683	201	46	the	the	DET
can-1683	201	47	other	other	ADJ
can-1683	201	48	hand	hand	NOUN
can-1683	201	49	,	,	PUNCT
can-1683	201	50	can	can	AUX
can-1683	201	51	offer	offer	VERB
can-1683	201	52	the	the	DET
can-1683	201	53	advantages	advantage	NOUN
can-1683	201	54	listed	list	VERB
can-1683	201	55	above	above	ADV
can-1683	201	56	.	.	PUNCT
can-1683	202	1	olmesartan	olmesartan	PROPN
can-1683	202	2	has	have	AUX
can-1683	202	3	been	be	AUX
can-1683	202	4	developed	develop	VERB
can-1683	202	5	into	into	ADP
can-1683	202	6	a	a	DET
can-1683	202	7	nanoemulsion	nanoemulsion	NOUN
can-1683	202	8	system	system	NOUN
can-1683	202	9	by	by	ADP
can-1683	202	10	certain	certain	ADJ
can-1683	202	11	researchers	researcher	NOUN
can-1683	202	12	.	.	PUNCT
can-1683	203	1	the	the	DET
can-1683	203	2	nanoemulsion	nanoemulsion	NOUN
can-1683	203	3	group	group	NOUN
can-1683	203	4	exhibits	exhibit	VERB
can-1683	203	5	greater	great	ADJ
can-1683	203	6	blood	blood	NOUN
can-1683	203	7	pressure	pressure	NOUN
can-1683	203	8	-	-	PUNCT
can-1683	203	9	lowering	lower	VERB
can-1683	203	10	effects	effect	NOUN
can-1683	203	11	,	,	PUNCT
can-1683	203	12	a	a	DET
can-1683	203	13	longer	long	ADJ
can-1683	203	14	maintenance	maintenance	NOUN
can-1683	203	15	period	period	NOUN
can-1683	203	16	,	,	PUNCT
can-1683	203	17	and	and	CCONJ
can-1683	203	18	nearly	nearly	ADV
can-1683	203	19	three	three	NUM
can-1683	203	20	times	time	NOUN
can-1683	203	21	the	the	DET
can-1683	203	22	dosage	dosage	NOUN
can-1683	203	23	decrease	decrease	NOUN
can-1683	203	24	than	than	ADP
can-1683	203	25	the	the	DET
can-1683	203	26	standard	standard	NOUN
can-1683	203	27	dose	dose	VERB
can-1683	203	28	group[47	group[47	PROPN
can-1683	203	29	]	]	PUNCT
can-1683	203	30	.	.	PUNCT
can-1683	204	1	6.3	6.3	NUM
can-1683	204	2	the	the	DET
can-1683	204	3	nddss	nddss	NOUN
can-1683	204	4	in	in	ADP
can-1683	204	5	pulmonary	pulmonary	ADJ
can-1683	204	6	hypertension	hypertension	NOUN
can-1683	204	7	increased	increase	VERB
can-1683	204	8	pulmonary	pulmonary	ADJ
can-1683	204	9	vascular	vascular	NOUN
can-1683	204	10	resistance	resistance	NOUN
can-1683	204	11	and	and	CCONJ
can-1683	204	12	raised	raise	VERB
can-1683	204	13	pulmonary	pulmonary	ADJ
can-1683	204	14	artery	artery	NOUN
can-1683	204	15	pressure	pressure	NOUN
can-1683	204	16	are	be	AUX
can-1683	204	17	the	the	DET
can-1683	204	18	hallmarks	hallmark	NOUN
can-1683	204	19	of	of	ADP
can-1683	204	20	pulmonary	pulmonary	ADJ
can-1683	204	21	hypertension	hypertension	NOUN
can-1683	204	22	.	.	PUNCT
can-1683	205	1	pulmonary	pulmonary	ADJ
can-1683	205	2	hypertension	hypertension	NOUN
can-1683	205	3	is	be	AUX
can-1683	205	4	commonly	commonly	ADV
can-1683	205	5	treated	treat	VERB
can-1683	205	6	with	with	ADP
can-1683	205	7	vasodilators	vasodilator	NOUN
can-1683	205	8	such	such	ADJ
can-1683	205	9	as	as	ADP
can-1683	205	10	prostaglandin	prostaglandin	PROPN
can-1683	205	11	i	i	PROPN
can-1683	205	12	,	,	PUNCT
can-1683	205	13	endothelin	endothelin	PROPN
can-1683	205	14	receptor	receptor	NOUN
can-1683	205	15	antagonist	antagonist	NOUN
can-1683	205	16	,	,	PUNCT
can-1683	205	17	type	type	NOUN
can-1683	205	18	5	5	NUM
can-1683	205	19	phosphodiesterase	phosphodiesterase	NOUN
can-1683	205	20	inhibitor	inhibitor	NOUN
can-1683	205	21	,	,	PUNCT
can-1683	205	22	and	and	CCONJ
can-1683	205	23	others	other	NOUN
can-1683	205	24	.	.	PUNCT
can-1683	206	1	the	the	DET
can-1683	206	2	therapeutic	therapeutic	ADJ
can-1683	206	3	potential	potential	NOUN
can-1683	206	4	of	of	ADP
can-1683	206	5	these	these	DET
can-1683	206	6	vasodilators	vasodilator	NOUN
can-1683	206	7	is	be	AUX
can-1683	206	8	limited	limit	VERB
can-1683	206	9	,	,	PUNCT
can-1683	206	10	however	however	ADV
can-1683	206	11	they	they	PRON
can-1683	206	12	have	have	AUX
can-1683	206	13	demonstrated	demonstrate	VERB
can-1683	206	14	some	some	DET
can-1683	206	15	results	result	NOUN
can-1683	206	16	.	.	PUNCT
can-1683	207	1	in	in	ADP
can-1683	207	2	order	order	NOUN
can-1683	207	3	to	to	PART
can-1683	207	4	address	address	VERB
can-1683	207	5	this	this	DET
can-1683	207	6	issue	issue	NOUN
can-1683	207	7	,	,	PUNCT
can-1683	207	8	nano	nano	NOUN
can-1683	207	9	-	-	PUNCT
can-1683	207	10	mediated	mediate	VERB
can-1683	207	11	drug	drug	NOUN
can-1683	207	12	delivery	delivery	NOUN
can-1683	207	13	systems	system	NOUN
can-1683	207	14	have	have	AUX
can-1683	207	15	become	become	VERB
can-1683	207	16	increasingly	increasingly	ADV
can-1683	207	17	relevant	relevant	ADJ
can-1683	207	18	.	.	PUNCT
can-1683	208	1	in	in	ADP
can-1683	208	2	nanoparticle	nanoparticle	NOUN
can-1683	208	3	form	form	NOUN
can-1683	208	4	,	,	PUNCT
can-1683	208	5	bosentan	bosentan	PROPN
can-1683	208	6	is	be	AUX
can-1683	208	7	an	an	DET
can-1683	208	8	endothelin	endothelin	PROPN
can-1683	208	9	receptor	receptor	NOUN
can-1683	208	10	antagonist	antagonist	NOUN
can-1683	208	11	that	that	PRON
can-1683	208	12	is	be	AUX
can-1683	208	13	seven	seven	NUM
can-1683	208	14	times	time	NOUN
can-1683	208	15	more	more	ADV
can-1683	208	16	soluble	soluble	ADJ
can-1683	208	17	than	than	ADP
can-1683	208	18	bosentan	bosentan	ADJ
can-1683	208	19	that	that	PRON
can-1683	208	20	has	have	AUX
can-1683	208	21	n’t	not	PART
can-1683	208	22	been	be	AUX
can-1683	208	23	treated[48	treated[48	NOUN
can-1683	208	24	]	]	X
can-1683	208	25	.	.	PUNCT
can-1683	209	1	6.4	6.4	NUM
can-1683	209	2	the	the	DET
can-1683	209	3	nddss	nddss	NOUN
can-1683	209	4	in	in	ADP
can-1683	209	5	myocardial	myocardial	ADJ
can-1683	209	6	infarction	infarction	NOUN
can-1683	209	7	apoptosis	apoptosis	NOUN
can-1683	209	8	,	,	PUNCT
can-1683	209	9	calcium	calcium	NOUN
can-1683	209	10	overload	overload	NOUN
can-1683	209	11	,	,	PUNCT
can-1683	209	12	and	and	CCONJ
can-1683	209	13	reactive	reactive	ADJ
can-1683	209	14	oxygen	oxygen	NOUN
can-1683	209	15	species	specie	NOUN
can-1683	209	16	have	have	AUX
can-1683	209	17	all	all	PRON
can-1683	209	18	been	be	AUX
can-1683	209	19	linked	link	VERB
can-1683	209	20	to	to	ADP
can-1683	209	21	reperfusion	reperfusion	NOUN
can-1683	209	22	therapy	therapy	NOUN
can-1683	209	23	,	,	PUNCT
can-1683	209	24	which	which	PRON
can-1683	209	25	is	be	AUX
can-1683	209	26	most	most	ADV
can-1683	209	27	commonly	commonly	ADV
can-1683	209	28	employed	employ	VERB
can-1683	209	29	in	in	ADP
can-1683	209	30	the	the	DET
can-1683	209	31	early	early	ADJ
can-1683	209	32	stages	stage	NOUN
can-1683	209	33	of	of	ADP
can-1683	209	34	a	a	DET
can-1683	209	35	myocardial	myocardial	ADJ
can-1683	209	36	infarction	infarction	NOUN
can-1683	209	37	.	.	PUNCT
can-1683	210	1	apoptosis	apoptosis	NOUN
can-1683	210	2	and	and	CCONJ
can-1683	210	3	necrosis	necrosis	NOUN
can-1683	210	4	of	of	ADP
can-1683	210	5	cardiomyocytes	cardiomyocyte	NOUN
can-1683	210	6	are	be	AUX
can-1683	210	7	promoted	promote	VERB
can-1683	210	8	by	by	ADP
can-1683	210	9	the	the	DET
can-1683	210	10	opening	opening	NOUN
can-1683	210	11	of	of	ADP
can-1683	210	12	the	the	DET
can-1683	210	13	mptp	mptp	NOUN
can-1683	210	14	and	and	CCONJ
can-1683	210	15	the	the	DET
can-1683	210	16	rise	rise	NOUN
can-1683	210	17	in	in	ADP
can-1683	210	18	mitochondrial	mitochondrial	ADJ
can-1683	210	19	outer	outer	ADJ
can-1683	210	20	membrane	membrane	NOUN
can-1683	210	21	permeability	permeability	NOUN
can-1683	210	22	as	as	ADP
can-1683	210	23	a	a	DET
can-1683	210	24	result	result	NOUN
can-1683	210	25	of	of	ADP
can-1683	210	26	these	these	PRON
can-1683	210	27	factors[49	factors[49	PROPN
can-1683	210	28	]	]	PUNCT
can-1683	210	29	.	.	PUNCT
can-1683	211	1	growth	growth	NOUN
can-1683	211	2	factors	factor	NOUN
can-1683	211	3	,	,	PUNCT
can-1683	211	4	cytokines	cytokine	NOUN
can-1683	211	5	,	,	PUNCT
can-1683	211	6	and	and	CCONJ
can-1683	211	7	other	other	ADJ
can-1683	211	8	small	small	ADJ
can-1683	211	9	molecular	molecular	ADJ
can-1683	211	10	substances	substance	NOUN
can-1683	211	11	are	be	AUX
can-1683	211	12	mostly	mostly	ADV
can-1683	211	13	used	use	VERB
can-1683	211	14	in	in	ADP
can-1683	211	15	clinical	clinical	ADJ
can-1683	211	16	practice	practice	NOUN
can-1683	211	17	to	to	PART
can-1683	211	18	treat	treat	VERB
can-1683	211	19	myocardial	myocardial	ADJ
can-1683	211	20	ischemia	ischemia	NOUN
can-1683	211	21	.	.	PUNCT
can-1683	212	1	the	the	DET
can-1683	212	2	drawbacks	drawback	NOUN
can-1683	212	3	of	of	ADP
can-1683	212	4	these	these	DET
can-1683	212	5	pharmaceuticals	pharmaceutical	NOUN
can-1683	212	6	are	be	AUX
can-1683	212	7	the	the	DET
can-1683	212	8	same	same	ADJ
can-1683	212	9	as	as	ADP
can-1683	212	10	those	those	PRON
can-1683	212	11	of	of	ADP
can-1683	212	12	the	the	DET
can-1683	212	13	standard	standard	ADJ
can-1683	212	14	medications	medication	NOUN
can-1683	212	15	listed	list	VERB
can-1683	212	16	above	above	ADV
can-1683	212	17	.	.	PUNCT
can-1683	213	1	in	in	ADP
can-1683	213	2	ischemic	ischemic	ADJ
can-1683	213	3	heart	heart	NOUN
can-1683	213	4	disease	disease	NOUN
can-1683	213	5	,	,	PUNCT
can-1683	213	6	high	high	ADJ
can-1683	213	7	blood	blood	NOUN
can-1683	213	8	permeability	permeability	NOUN
can-1683	213	9	and	and	CCONJ
can-1683	213	10	an	an	DET
can-1683	213	11	abundance	abundance	NOUN
can-1683	213	12	of	of	ADP
can-1683	213	13	monocytes	monocyte	NOUN
can-1683	213	14	can	can	AUX
can-1683	213	15	be	be	AUX
can-1683	213	16	utilized	utilize	VERB
can-1683	213	17	to	to	PART
can-1683	213	18	deliver	deliver	VERB
can-1683	213	19	medications	medication	NOUN
can-1683	213	20	through	through	ADP
can-1683	213	21	the	the	DET
can-1683	213	22	targeting	targeting	NOUN
can-1683	213	23	ability	ability	NOUN
can-1683	213	24	of	of	ADP
can-1683	213	25	nano	nano	NOUN
can-1683	213	26	-	-	PUNCT
can-1683	213	27	carriers	carrier	NOUN
can-1683	213	28	.	.	PUNCT
can-1683	214	1	6.5	6.5	NUM
can-1683	214	2	the	the	DET
can-1683	214	3	nddss	nddss	NOUN
can-1683	214	4	in	in	ADP
can-1683	214	5	other	other	ADJ
can-1683	214	6	cvds	cvds	NOUN
can-1683	214	7	additionally	additionally	ADV
can-1683	214	8	,	,	PUNCT
can-1683	214	9	the	the	DET
can-1683	214	10	nano	nano	NOUN
can-1683	214	11	-	-	PUNCT
can-1683	214	12	drug	drug	NOUN
can-1683	214	13	delivery	delivery	NOUN
can-1683	214	14	method	method	NOUN
can-1683	214	15	works	work	VERB
can-1683	214	16	effectively	effectively	ADV
can-1683	214	17	in	in	ADP
can-1683	214	18	the	the	DET
can-1683	214	19	treatment	treatment	NOUN
can-1683	214	20	of	of	ADP
can-1683	214	21	various	various	ADJ
can-1683	214	22	cardiovascular	cardiovascular	ADJ
can-1683	214	23	diseases	disease	NOUN
can-1683	214	24	.	.	PUNCT
can-1683	215	1	allogeneic	allogeneic	VERB
can-1683	215	2	angiopathy	angiopathy	ADJ
can-1683	215	3	of	of	ADP
can-1683	215	4	the	the	DET
can-1683	215	5	coronary	coronary	ADJ
can-1683	215	6	arteries	artery	NOUN
can-1683	215	7	is	be	AUX
can-1683	215	8	an	an	DET
can-1683	215	9	inflammatory	inflammatory	ADJ
can-1683	215	10	process	process	NOUN
can-1683	215	11	of	of	ADP
can-1683	215	12	proliferation	proliferation	NOUN
can-1683	215	13	that	that	PRON
can-1683	215	14	threatens	threaten	VERB
can-1683	215	15	the	the	DET
can-1683	215	16	long	long	ADJ
can-1683	215	17	-	-	PUNCT
can-1683	215	18	term	term	NOUN
can-1683	215	19	effectiveness	effectiveness	NOUN
can-1683	215	20	of	of	ADP
can-1683	215	21	heart	heart	NOUN
can-1683	215	22	transplantation	transplantation	NOUN
can-1683	215	23	.	.	PUNCT
can-1683	216	1	using	use	VERB
can-1683	216	2	methotrexate	methotrexate	NOUN
can-1683	216	3	or	or	CCONJ
can-1683	216	4	paclitaxel	paclitaxel	NOUN
can-1683	216	5	-	-	PUNCT
can-1683	216	6	coated	coat	VERB
can-1683	216	7	lipid	lipid	NOUN
can-1683	216	8	nanoparticles	nanoparticle	NOUN
can-1683	216	9	,	,	PUNCT
can-1683	216	10	researchers	researcher	NOUN
can-1683	216	11	administered	administer	VERB
can-1683	216	12	them	they	PRON
can-1683	216	13	intravenously	intravenously	ADV
can-1683	216	14	to	to	ADP
can-1683	216	15	rabbits	rabbit	NOUN
can-1683	216	16	receiving	receive	VERB
can-1683	216	17	an	an	DET
can-1683	216	18	ectopic	ectopic	ADJ
can-1683	216	19	heart	heart	NOUN
can-1683	216	20	transplant	transplant	NOUN
can-1683	216	21	and	and	CCONJ
can-1683	216	22	fed	feed	VERB
can-1683	216	23	them	they	PRON
can-1683	216	24	a	a	DET
can-1683	216	25	cholesterol	cholesterol	NOUN
can-1683	216	26	-	-	PUNCT
can-1683	216	27	rich	rich	ADJ
can-1683	216	28	diet[50	diet[50	NOUN
can-1683	216	29	]	]	PUNCT
can-1683	216	30	.	.	PUNCT
can-1683	217	1	insufficient	insufficient	ADJ
can-1683	217	2	oxygen	oxygen	NOUN
can-1683	217	3	supply	supply	NOUN
can-1683	217	4	and	and	CCONJ
can-1683	217	5	unstable	unstable	ADJ
can-1683	217	6	myocardial	myocardial	ADJ
can-1683	217	7	energy	energy	NOUN
can-1683	217	8	metabolism	metabolism	NOUN
can-1683	217	9	are	be	AUX
can-1683	217	10	the	the	DET
can-1683	217	11	primary	primary	ADJ
can-1683	217	12	causes	cause	NOUN
can-1683	217	13	of	of	ADP
can-1683	217	14	myocardial	myocardial	ADJ
can-1683	217	15	ischemia	ischemia	NOUN
can-1683	217	16	,	,	PUNCT
can-1683	217	17	a	a	DET
can-1683	217	18	condition	condition	NOUN
can-1683	217	19	that	that	PRON
can-1683	217	20	ca	can	AUX
can-1683	217	21	n’t	not	PART
can-1683	217	22	sustain	sustain	VERB
can-1683	217	23	the	the	DET
can-1683	217	24	heart	heart	NOUN
can-1683	217	25	’s	’s	PART
can-1683	217	26	regular	regular	ADJ
can-1683	217	27	functions	function	NOUN
can-1683	217	28	.	.	PUNCT
can-1683	218	1	thin	thin	ADJ
can-1683	218	2	film	film	NOUN
can-1683	218	3	dispersion	dispersion	NOUN
can-1683	218	4	was	be	AUX
can-1683	218	5	used	use	VERB
can-1683	218	6	to	to	PART
can-1683	218	7	make	make	VERB
can-1683	218	8	liposomes	liposome	NOUN
can-1683	218	9	coated	coat	VERB
can-1683	218	10	with	with	ADP
can-1683	218	11	phenytoin	phenytoin	PROPN
can-1683	218	12	(	(	PUNCT
can-1683	218	13	pht	pht	PROPN
can-1683	218	14	,	,	PUNCT
can-1683	218	15	a	a	DET
can-1683	218	16	non	non	ADJ
can-1683	218	17	-	-	ADJ
can-1683	218	18	selective	selective	ADJ
can-1683	218	19	vgsc	vgsc	ADJ
can-1683	218	20	inhibitor	inhibitor	NOUN
can-1683	218	21	)	)	PUNCT
can-1683	218	22	.	.	PUNCT
can-1683	219	1	pht	pht	PROPN
can-1683	219	2	-	-	PUNCT
can-1683	219	3	encapsulated	encapsulate	VERB
can-1683	219	4	liposomes	liposome	NOUN
can-1683	219	5	partly	partly	ADV
can-1683	219	6	suppressed	suppress	VERB
can-1683	219	7	i	i	PRON
can-1683	219	8	/	/	SYM
can-1683	219	9	r	r	NOUN
can-1683	219	10	injury	injury	NOUN
can-1683	219	11	-	-	PUNCT
can-1683	219	12	induced	induce	VERB
can-1683	219	13	cd43	cd43	PROPN
can-1683	219	14	+	+	CCONJ
can-1683	219	15	inflammatory	inflammatory	ADJ
can-1683	219	16	monocyte	monocyte	NOUN
can-1683	219	17	growth	growth	NOUN
can-1683	219	18	and	and	CCONJ
can-1683	219	19	decreased	decrease	VERB
can-1683	219	20	infarct	infarct	NOUN
can-1683	219	21	size	size	NOUN
can-1683	219	22	and	and	CCONJ
can-1683	219	23	left	leave	VERB
can-1683	219	24	ventricular	ventricular	ADJ
can-1683	219	25	fibrosis	fibrosis	NOUN
can-1683	219	26	after	after	ADP
can-1683	219	27	intravenous	intravenous	ADJ
can-1683	219	28	injection	injection	NOUN
can-1683	219	29	of	of	ADP
can-1683	219	30	the	the	DET
can-1683	219	31	rat	rat	NOUN
can-1683	219	32	myocardial	myocardial	NOUN
can-1683	219	33	i	i	PROPN
can-1683	219	34	/	/	SYM
can-1683	219	35	r	r	NOUN
can-1683	219	36	injury	injury	NOUN
can-1683	219	37	model[51	model[51	PROPN
can-1683	219	38	]	]	PUNCT
can-1683	219	39	.	.	PUNCT
can-1683	220	1	after	after	ADP
can-1683	220	2	an	an	DET
can-1683	220	3	angioplasty	angioplasty	NOUN
can-1683	220	4	,	,	PUNCT
can-1683	220	5	an	an	DET
can-1683	220	6	arteriotomy	arteriotomy	NOUN
can-1683	220	7	,	,	PUNCT
can-1683	220	8	or	or	CCONJ
can-1683	220	9	the	the	DET
can-1683	220	10	implantation	implantation	NOUN
can-1683	220	11	of	of	ADP
can-1683	220	12	an	an	DET
can-1683	220	13	endovascular	endovascular	ADJ
can-1683	220	14	stent	stent	NOUN
can-1683	220	15	,	,	PUNCT
can-1683	220	16	the	the	DET
can-1683	220	17	blood	blood	NOUN
can-1683	220	18	arteries	artery	NOUN
can-1683	220	19	might	might	AUX
can-1683	220	20	become	become	VERB
can-1683	220	21	stenotic	stenotic	ADJ
can-1683	220	22	and	and	CCONJ
can-1683	220	23	blocked	block	VERB
can-1683	220	24	again	again	ADV
can-1683	220	25	,	,	PUNCT
can-1683	220	26	a	a	DET
can-1683	220	27	condition	condition	NOUN
can-1683	220	28	known	know	VERB
can-1683	220	29	as	as	ADP
can-1683	220	30	vascular	vascular	ADJ
can-1683	220	31	restenosis	restenosis	NOUN
can-1683	220	32	.	.	PUNCT
can-1683	221	1	catheter	catheter	NOUN
can-1683	221	2	-	-	PUNCT
can-1683	221	3	intervention	intervention	NOUN
can-1683	221	4	methods	method	NOUN
can-1683	221	5	may	may	AUX
can-1683	221	6	be	be	AUX
can-1683	221	7	employed	employ	VERB
can-1683	221	8	to	to	PART
can-1683	221	9	pump	pump	VERB
can-1683	221	10	18	18	NUM
can-1683	221	11	drug	drug	NOUN
can-1683	221	12	-	-	PUNCT
can-1683	221	13	loaded	load	VERB
can-1683	221	14	nanoparticles	nanoparticle	NOUN
can-1683	221	15	into	into	ADP
can-1683	221	16	the	the	DET
can-1683	221	17	damage	damage	NOUN
can-1683	221	18	site	site	NOUN
can-1683	221	19	to	to	PART
can-1683	221	20	enable	enable	VERB
can-1683	221	21	angioplasty	angioplasty	NOUN
can-1683	221	22	and	and	CCONJ
can-1683	221	23	topical	topical	ADJ
can-1683	221	24	delivery	delivery	NOUN
can-1683	221	25	in	in	ADP
can-1683	221	26	one	one	NUM
can-1683	221	27	step	step	NOUN
can-1683	221	28	.	.	PUNCT
can-1683	222	1	through	through	ADP
can-1683	222	2	the	the	DET
can-1683	222	3	compromised	compromised	ADJ
can-1683	222	4	endothelium	endothelium	NOUN
can-1683	222	5	,	,	PUNCT
can-1683	222	6	the	the	DET
can-1683	222	7	nanoparticles	nanoparticle	NOUN
can-1683	222	8	can	can	AUX
can-1683	222	9	infiltrate	infiltrate	VERB
can-1683	222	10	the	the	DET
can-1683	222	11	artery	artery	NOUN
can-1683	222	12	wall	wall	NOUN
can-1683	222	13	,	,	PUNCT
can-1683	222	14	locate	locate	VERB
can-1683	222	15	,	,	PUNCT
can-1683	222	16	and	and	CCONJ
can-1683	222	17	then	then	ADV
can-1683	222	18	slowly	slowly	ADV
can-1683	222	19	release	release	VERB
can-1683	222	20	the	the	DET
can-1683	222	21	medicine[52	medicine[52	NOUN
can-1683	222	22	]	]	X
can-1683	222	23	.	.	PUNCT
can-1683	223	1	a	a	DET
can-1683	223	2	high	high	ADJ
can-1683	223	3	concentration	concentration	NOUN
can-1683	223	4	of	of	ADP
can-1683	223	5	medicine	medicine	NOUN
can-1683	223	6	in	in	ADP
can-1683	223	7	the	the	DET
can-1683	223	8	lesion	lesion	NOUN
can-1683	223	9	vessel	vessel	NOUN
can-1683	223	10	may	may	AUX
can-1683	223	11	be	be	AUX
can-1683	223	12	maintained	maintain	VERB
can-1683	223	13	for	for	ADP
can-1683	223	14	a	a	DET
can-1683	223	15	long	long	ADJ
can-1683	223	16	length	length	NOUN
can-1683	223	17	of	of	ADP
can-1683	223	18	time	time	NOUN
can-1683	223	19	,	,	PUNCT
can-1683	223	20	which	which	PRON
can-1683	223	21	is	be	AUX
can-1683	223	22	advantageous	advantageous	ADJ
can-1683	223	23	to	to	ADP
can-1683	223	24	maximizing	maximize	VERB
can-1683	223	25	the	the	DET
can-1683	223	26	drug	drug	NOUN
can-1683	223	27	’s	’s	PART
can-1683	223	28	action	action	NOUN
can-1683	223	29	and	and	CCONJ
can-1683	223	30	preventing	prevent	VERB
can-1683	223	31	vascular	vascular	ADJ
can-1683	223	32	restenosis	restenosis	NOUN
can-1683	223	33	as	as	ADV
can-1683	223	34	well	well	ADV
can-1683	223	35	.	.	PUNCT
can-1683	224	1	7	7	X
can-1683	224	2	.	.	X
can-1683	224	3	application	application	NOUN
can-1683	224	4	of	of	ADP
can-1683	224	5	the	the	DET
can-1683	224	6	co	co	ADJ
can-1683	224	7	-	-	ADJ
can-1683	224	8	loaded	load	VERB
can-1683	224	9	nano	nano	NOUN
can-1683	224	10	-	-	PUNCT
can-1683	224	11	system	system	NOUN
can-1683	224	12	in	in	ADP
can-1683	224	13	the	the	DET
can-1683	224	14	cvds	cvds	NOUN
can-1683	224	15	when	when	SCONJ
can-1683	224	16	two	two	NUM
can-1683	224	17	or	or	CCONJ
can-1683	224	18	more	more	ADJ
can-1683	224	19	medications	medication	NOUN
can-1683	224	20	are	be	AUX
can-1683	224	21	administered	administer	VERB
can-1683	224	22	to	to	ADP
can-1683	224	23	a	a	DET
can-1683	224	24	patient	patient	NOUN
can-1683	224	25	at	at	ADP
can-1683	224	26	the	the	DET
can-1683	224	27	same	same	ADJ
can-1683	224	28	time	time	NOUN
can-1683	224	29	,	,	PUNCT
can-1683	224	30	we	we	PRON
can-1683	224	31	say	say	VERB
can-1683	224	32	that	that	SCONJ
can-1683	224	33	we	we	PRON
can-1683	224	34	are	be	AUX
can-1683	224	35	using	use	VERB
can-1683	224	36	drug	drug	NOUN
can-1683	224	37	combination	combination	NOUN
can-1683	224	38	therapy	therapy	NOUN
can-1683	224	39	.	.	PUNCT
can-1683	225	1	this	this	DET
can-1683	225	2	treatment	treatment	NOUN
can-1683	225	3	has	have	AUX
can-1683	225	4	been	be	AUX
can-1683	225	5	widely	widely	ADV
can-1683	225	6	utilized	utilize	VERB
can-1683	225	7	in	in	ADP
can-1683	225	8	the	the	DET
can-1683	225	9	medical	medical	ADJ
can-1683	225	10	community	community	NOUN
can-1683	225	11	to	to	PART
can-1683	225	12	treat	treat	VERB
can-1683	225	13	a	a	DET
can-1683	225	14	variety	variety	NOUN
can-1683	225	15	of	of	ADP
can-1683	225	16	diseases	disease	NOUN
can-1683	225	17	.	.	PUNCT
can-1683	226	1	the	the	DET
can-1683	226	2	synergistic	synergistic	ADJ
can-1683	226	3	effect	effect	NOUN
can-1683	226	4	of	of	ADP
can-1683	226	5	medications	medication	NOUN
can-1683	226	6	,	,	PUNCT
can-1683	226	7	or	or	CCONJ
can-1683	226	8	the	the	DET
can-1683	226	9	therapeutic	therapeutic	ADJ
can-1683	226	10	benefit	benefit	NOUN
can-1683	226	11	of	of	ADP
can-1683	226	12	numerous	numerous	ADJ
can-1683	226	13	drugs	drug	NOUN
can-1683	226	14	which	which	PRON
can-1683	226	15	is	be	AUX
can-1683	226	16	larger	large	ADJ
can-1683	226	17	than	than	ADP
can-1683	226	18	that	that	PRON
can-1683	226	19	of	of	ADP
can-1683	226	20	a	a	DET
can-1683	226	21	single	single	ADJ
can-1683	226	22	drug	drug	NOUN
can-1683	226	23	,	,	PUNCT
can-1683	226	24	is	be	AUX
can-1683	226	25	typically	typically	ADV
can-1683	226	26	a	a	DET
can-1683	226	27	factor	factor	NOUN
can-1683	226	28	in	in	ADP
can-1683	226	29	the	the	DET
can-1683	226	30	use	use	NOUN
can-1683	226	31	of	of	ADP
can-1683	226	32	this	this	DET
can-1683	226	33	combination	combination	NOUN
can-1683	226	34	treatment	treatment	NOUN
can-1683	226	35	.	.	PUNCT
can-1683	227	1	recent	recent	ADJ
can-1683	227	2	years	year	NOUN
can-1683	227	3	have	have	AUX
can-1683	227	4	seen	see	VERB
can-1683	227	5	the	the	DET
can-1683	227	6	development	development	NOUN
can-1683	227	7	of	of	ADP
can-1683	227	8	several	several	ADJ
can-1683	227	9	co	co	VERB
can-1683	227	10	-	-	ADJ
can-1683	227	11	loaded	load	VERB
can-1683	227	12	nano	nano	NOUN
can-1683	227	13	-	-	PUNCT
can-1683	227	14	systems	system	NOUN
can-1683	227	15	that	that	PRON
can-1683	227	16	carry	carry	VERB
can-1683	227	17	medications	medication	NOUN
can-1683	227	18	and/or	and/or	CCONJ
can-1683	227	19	genes	gene	NOUN
can-1683	227	20	,	,	PUNCT
can-1683	227	21	particularly	particularly	ADV
can-1683	227	22	sirna	sirna	PROPN
can-1683	227	23	,	,	PUNCT
can-1683	227	24	for	for	ADP
can-1683	227	25	the	the	DET
can-1683	227	26	treatment	treatment	NOUN
can-1683	227	27	of	of	ADP
can-1683	227	28	cardiovascular	cardiovascular	ADJ
can-1683	227	29	disease	disease	NOUN
can-1683	227	30	.	.	PUNCT
can-1683	228	1	8	8	X
can-1683	228	2	.	.	X
can-1683	228	3	application	application	NOUN
can-1683	228	4	of	of	ADP
can-1683	228	5	rnai	rnai	PROPN
can-1683	228	6	in	in	ADP
can-1683	228	7	the	the	DET
can-1683	228	8	treatment	treatment	NOUN
can-1683	228	9	of	of	ADP
can-1683	228	10	cvds	cvds	PROPN
can-1683	228	11	rna	rna	PROPN
can-1683	228	12	interference	interference	NOUN
can-1683	228	13	(	(	PUNCT
can-1683	228	14	rnai	rnai	PROPN
can-1683	228	15	)	)	PUNCT
can-1683	228	16	is	be	AUX
can-1683	228	17	a	a	DET
can-1683	228	18	gene	gene	NOUN
can-1683	228	19	-	-	PUNCT
can-1683	228	20	specific	specific	ADJ
can-1683	228	21	silencing	silencing	NOUN
can-1683	228	22	process	process	NOUN
can-1683	228	23	that	that	PRON
can-1683	228	24	is	be	AUX
can-1683	228	25	present	present	ADJ
can-1683	228	26	in	in	ADP
can-1683	228	27	eukaryotic	eukaryotic	ADJ
can-1683	228	28	cells	cell	NOUN
can-1683	228	29	and	and	CCONJ
can-1683	228	30	an	an	DET
can-1683	228	31	essential	essential	ADJ
can-1683	228	32	tool	tool	NOUN
can-1683	228	33	for	for	ADP
can-1683	228	34	preventing	prevent	VERB
can-1683	228	35	the	the	DET
can-1683	228	36	spread	spread	NOUN
can-1683	228	37	of	of	ADP
can-1683	228	38	alien	alien	ADJ
can-1683	228	39	genes	gene	NOUN
can-1683	228	40	and	and	CCONJ
can-1683	228	41	viruses	virus	NOUN
can-1683	228	42	.	.	PUNCT
can-1683	229	1	when	when	SCONJ
can-1683	229	2	rnai	rnai	PROPN
can-1683	229	3	was	be	AUX
can-1683	229	4	initially	initially	ADV
can-1683	229	5	identified	identify	VERB
can-1683	229	6	in	in	ADP
can-1683	229	7	c.	c.	PROPN
can-1683	229	8	elegans	elegan	NOUN
can-1683	229	9	,	,	PUNCT
can-1683	229	10	it	it	PRON
can-1683	229	11	was	be	AUX
can-1683	229	12	later	later	ADV
can-1683	229	13	shown	show	VERB
can-1683	229	14	to	to	PART
can-1683	229	15	be	be	AUX
can-1683	229	16	present	present	ADJ
can-1683	229	17	in	in	ADP
can-1683	229	18	human	human	ADJ
can-1683	229	19	cells[53	cells[53	PROPN
can-1683	229	20	]	]	PUNCT
can-1683	229	21	.	.	PUNCT
can-1683	230	1	a	a	DET
can-1683	230	2	variety	variety	NOUN
can-1683	230	3	of	of	ADP
can-1683	230	4	rna	rna	NOUN
can-1683	230	5	interference	interference	NOUN
can-1683	230	6	mechanisms	mechanism	NOUN
can-1683	230	7	exist	exist	VERB
can-1683	230	8	,	,	PUNCT
can-1683	230	9	including	include	VERB
can-1683	230	10	mirna	mirna	PROPN
can-1683	230	11	,	,	PUNCT
can-1683	230	12	sirna	sirna	PROPN
can-1683	230	13	,	,	PUNCT
can-1683	230	14	piwi	piwi	NOUN
can-1683	230	15	-	-	PUNCT
can-1683	230	16	interacting	interact	VERB
can-1683	230	17	rna	rna	NOUN
can-1683	230	18	,	,	PUNCT
can-1683	230	19	and	and	CCONJ
can-1683	230	20	long	long	ADJ
can-1683	230	21	non	non	ADJ
can-1683	230	22	-	-	ADJ
can-1683	230	23	coding	coding	ADJ
can-1683	230	24	rna	rna	NOUN
can-1683	230	25	(	(	PUNCT
can-1683	230	26	lncrna	lncrna	NOUN
can-1683	230	27	)	)	PUNCT
can-1683	230	28	(	(	PUNCT
can-1683	230	29	lncrna	lncrna	NOUN
can-1683	230	30	)	)	PUNCT
can-1683	230	31	.	.	PUNCT
can-1683	231	1	cell	cell	NOUN
can-1683	231	2	-	-	PUNCT
can-1683	231	3	specific	specific	ADJ
can-1683	231	4	genes	gene	NOUN
can-1683	231	5	may	may	AUX
can-1683	231	6	be	be	AUX
can-1683	231	7	silenced	silence	VERB
can-1683	231	8	using	use	VERB
can-1683	231	9	rnai	rnai	PROPN
can-1683	231	10	technology	technology	PROPN
can-1683	231	11	,	,	PUNCT
can-1683	231	12	which	which	PRON
can-1683	231	13	involves	involve	VERB
can-1683	231	14	introducing	introduce	VERB
can-1683	231	15	double	double	ADJ
can-1683	231	16	-	-	PUNCT
can-1683	231	17	stranded	strand	VERB
can-1683	231	18	rna	rna	NOUN
can-1683	231	19	(	(	PUNCT
can-1683	231	20	dsrna	dsrna	NOUN
can-1683	231	21	)	)	PUNCT
can-1683	231	22	into	into	ADP
can-1683	231	23	cells	cell	NOUN
can-1683	231	24	,	,	PUNCT
can-1683	231	25	degrading	degrade	VERB
can-1683	231	26	mrna	mrna	NOUN
can-1683	231	27	homologously	homologously	ADV
can-1683	231	28	complementary	complementary	ADJ
can-1683	231	29	to	to	ADP
can-1683	231	30	the	the	DET
can-1683	231	31	dsrna	dsrna	NOUN
can-1683	231	32	and	and	CCONJ
can-1683	231	33	limiting	limit	VERB
can-1683	231	34	its	its	PRON
can-1683	231	35	expression	expression	NOUN
can-1683	231	36	.	.	PUNCT
can-1683	232	1	development	development	NOUN
can-1683	232	2	of	of	ADP
can-1683	232	3	rnai	rnai	PROPN
can-1683	232	4	research	research	PROPN
can-1683	232	5	has	have	AUX
can-1683	232	6	led	lead	VERB
can-1683	232	7	to	to	ADP
can-1683	232	8	it	it	PRON
can-1683	232	9	becoming	become	VERB
can-1683	232	10	a	a	DET
can-1683	232	11	therapeutic	therapeutic	ADJ
can-1683	232	12	development	development	NOUN
can-1683	232	13	tool	tool	NOUN
can-1683	232	14	for	for	ADP
can-1683	232	15	the	the	DET
can-1683	232	16	treatment	treatment	NOUN
can-1683	232	17	of	of	ADP
can-1683	232	18	cvds[54	cvds[54	NOUN
can-1683	232	19	]	]	PUNCT
can-1683	232	20	.	.	PUNCT
can-1683	233	1	additionally	additionally	ADV
can-1683	233	2	,	,	PUNCT
can-1683	233	3	rna	rna	NOUN
can-1683	233	4	interference	interference	NOUN
can-1683	233	5	therapy	therapy	NOUN
can-1683	233	6	for	for	ADP
can-1683	233	7	the	the	DET
can-1683	233	8	treatment	treatment	NOUN
can-1683	233	9	of	of	ADP
can-1683	233	10	cvd	cvd	PROPN
can-1683	233	11	has	have	VERB
can-1683	233	12	its	its	PRON
can-1683	233	13	own	own	ADJ
can-1683	233	14	set	set	NOUN
can-1683	233	15	of	of	ADP
can-1683	233	16	obstacles	obstacle	NOUN
can-1683	233	17	,	,	PUNCT
can-1683	233	18	including	include	VERB
can-1683	233	19	toxicity	toxicity	NOUN
can-1683	233	20	,	,	PUNCT
can-1683	233	21	targeting	targeting	NOUN
can-1683	233	22	,	,	PUNCT
can-1683	233	23	temporal	temporal	ADJ
can-1683	233	24	impact	impact	NOUN
can-1683	233	25	,	,	PUNCT
can-1683	233	26	and	and	CCONJ
can-1683	233	27	effective	effective	ADJ
can-1683	233	28	delivery	delivery	NOUN
can-1683	233	29	method	method	NOUN
can-1683	233	30	,	,	PUNCT
can-1683	233	31	which	which	PRON
can-1683	233	32	restrict	restrict	VERB
can-1683	233	33	its	its	PRON
can-1683	233	34	broad	broad	ADJ
can-1683	233	35	usage	usage	NOUN
can-1683	233	36	in	in	ADP
can-1683	233	37	the	the	DET
can-1683	233	38	clinic	clinic	NOUN
can-1683	233	39	and	and	CCONJ
can-1683	233	40	are	be	AUX
can-1683	233	41	urgently	urgently	ADV
can-1683	233	42	needed	need	VERB
can-1683	233	43	to	to	PART
can-1683	233	44	be	be	AUX
can-1683	233	45	resolved	resolve	VERB
can-1683	233	46	and	and	CCONJ
can-1683	233	47	improved[55	improved[55	NOUN
can-1683	233	48	]	]	PUNCT
can-1683	233	49	.	.	PUNCT
can-1683	234	1	rna	rna	NOUN
can-1683	234	2	interference	interference	NOUN
can-1683	234	3	in	in	ADP
can-1683	234	4	the	the	DET
can-1683	234	5	cardiovascular	cardiovascular	ADJ
can-1683	234	6	system	system	NOUN
can-1683	234	7	is	be	AUX
can-1683	234	8	expected	expect	VERB
can-1683	234	9	to	to	PART
can-1683	234	10	take	take	VERB
can-1683	234	11	a	a	DET
can-1683	234	12	new	new	ADJ
can-1683	234	13	turn	turn	NOUN
can-1683	234	14	.	.	PUNCT
can-1683	235	1	9	9	X
can-1683	235	2	.	.	X
can-1683	235	3	co	co	VERB
can-1683	235	4	-	-	VERB
can-1683	235	5	loaded	load	VERB
can-1683	235	6	gene	gene	NOUN
can-1683	235	7	and	and	CCONJ
can-1683	235	8	drug	drug	NOUN
can-1683	235	9	nano	nano	NOUN
can-1683	235	10	-	-	PUNCT
can-1683	235	11	system	system	NOUN
can-1683	235	12	in	in	ADP
can-1683	235	13	order	order	NOUN
can-1683	235	14	to	to	PART
can-1683	235	15	overcome	overcome	VERB
can-1683	235	16	the	the	DET
can-1683	235	17	difficulties	difficulty	NOUN
can-1683	235	18	in	in	ADP
can-1683	235	19	the	the	DET
can-1683	235	20	delivery	delivery	NOUN
can-1683	235	21	process	process	NOUN
can-1683	235	22	and	and	CCONJ
can-1683	235	23	realise	realise	VERB
can-1683	235	24	the	the	DET
can-1683	235	25	full	full	ADJ
can-1683	235	26	potential	potential	NOUN
can-1683	235	27	of	of	ADP
can-1683	235	28	rnai	rnai	PROPN
can-1683	235	29	-	-	PUNCT
can-1683	235	30	based	base	VERB
can-1683	235	31	therapies	therapy	NOUN
can-1683	235	32	,	,	PUNCT
can-1683	235	33	safe	safe	ADJ
can-1683	235	34	and	and	CCONJ
can-1683	235	35	effective	effective	ADJ
can-1683	235	36	nano	nano	NOUN
can-1683	235	37	delivery	delivery	NOUN
can-1683	235	38	devices	device	NOUN
can-1683	235	39	are	be	AUX
can-1683	235	40	essential	essential	ADJ
can-1683	235	41	.	.	PUNCT
can-1683	236	1	the	the	DET
can-1683	236	2	liposome	liposome	NOUN
can-1683	236	3	vector	vector	NOUN
can-1683	236	4	was	be	AUX
can-1683	236	5	used	use	VERB
can-1683	236	6	to	to	PART
can-1683	236	7	contain	contain	VERB
can-1683	236	8	the	the	DET
can-1683	236	9	apolipoprotein	apolipoprotein	ADJ
can-1683	236	10	b	b	PROPN
can-1683	236	11	(	(	PUNCT
can-1683	236	12	apob	apob	PROPN
can-1683	236	13	)	)	PUNCT
can-1683	236	14	sirna	sirna	PROPN
can-1683	236	15	.	.	PUNCT
can-1683	237	1	when	when	SCONJ
can-1683	237	2	the	the	DET
can-1683	237	3	liver	liver	NOUN
can-1683	237	4	apob	apob	PROPN
can-1683	237	5	mrna	mrna	PROPN
can-1683	237	6	was	be	AUX
can-1683	237	7	tested	test	VERB
can-1683	237	8	after	after	ADP
can-1683	237	9	48	48	NUM
can-1683	237	10	hours	hour	NOUN
can-1683	237	11	,	,	PUNCT
can-1683	237	12	the	the	DET
can-1683	237	13	silencing	silence	VERB
can-1683	237	14	rate	rate	NOUN
can-1683	237	15	was	be	AUX
can-1683	237	16	over	over	ADP
can-1683	237	17	90	90	NUM
can-1683	237	18	%	%	NOUN
can-1683	237	19	.	.	PUNCT
can-1683	238	1	when	when	SCONJ
can-1683	238	2	apob	apob	ADJ
can-1683	238	3	protein	protein	NOUN
can-1683	238	4	and	and	CCONJ
can-1683	238	5	blood	blood	NOUN
can-1683	238	6	cholesterol	cholesterol	NOUN
can-1683	238	7	levels	level	NOUN
can-1683	238	8	began	begin	VERB
can-1683	238	9	to	to	PART
can-1683	238	10	fall	fall	VERB
can-1683	238	11	24	24	NUM
can-1683	238	12	hours	hour	NOUN
can-1683	238	13	after	after	ADP
can-1683	238	14	therapy	therapy	NOUN
can-1683	238	15	,	,	PUNCT
can-1683	238	16	the	the	DET
can-1683	238	17	effects	effect	NOUN
can-1683	238	18	lasted	last	VERB
can-1683	238	19	until	until	ADP
can-1683	238	20	day	day	NOUN
can-1683	238	21	11	11	NUM
can-1683	238	22	of	of	ADP
can-1683	238	23	treatment[56	treatment[56	NOUN
can-1683	238	24	]	]	PUNCT
can-1683	238	25	.	.	PUNCT
can-1683	239	1	researchers	researcher	NOUN
can-1683	239	2	have	have	AUX
can-1683	239	3	created	create	VERB
can-1683	239	4	and	and	CCONJ
can-1683	239	5	packaged	package	VERB
can-1683	239	6	small	small	ADJ
can-1683	239	7	interfering	interfere	VERB
can-1683	239	8	rna	rna	NOUN
can-1683	239	9	(	(	PUNCT
can-1683	239	10	sirna	sirna	PROPN
can-1683	239	11	)	)	PUNCT
can-1683	239	12	against	against	ADP
can-1683	239	13	the	the	DET
can-1683	239	14	pdgf	pdgf	ADJ
can-1683	239	15	-	-	PUNCT
can-1683	239	16	b	b	NOUN
can-1683	239	17	mrna	mrna	NOUN
can-1683	239	18	expression	expression	NOUN
can-1683	239	19	vector	vector	NOUN
can-1683	239	20	using	use	VERB
can-1683	239	21	chitosan	chitosan	ADJ
can-1683	239	22	nanoparticles	nanoparticle	NOUN
can-1683	239	23	,	,	PUNCT
can-1683	239	24	and	and	CCONJ
can-1683	239	25	then	then	ADV
can-1683	239	26	employed	employ	VERB
can-1683	239	27	therapeutic	therapeutic	ADJ
can-1683	239	28	ultrasound	ultrasound	NOUN
can-1683	239	29	to	to	ADP
can-1683	239	30	transfect	transfect	VERB
can-1683	239	31	the	the	DET
can-1683	239	32	vascular	vascular	ADJ
can-1683	239	33	smooth	smooth	ADJ
can-1683	239	34	muscle	muscle	NOUN
can-1683	239	35	cells	cell	NOUN
can-1683	239	36	(	(	PUNCT
can-1683	239	37	vsmc	vsmc	NOUN
can-1683	239	38	)	)	PUNCT
can-1683	239	39	of	of	ADP
can-1683	239	40	rabbit	rabbit	NOUN
can-1683	239	41	artery	artery	NOUN
can-1683	239	42	wall	wall	NOUN
can-1683	239	43	injured	injure	VERB
can-1683	239	44	by	by	ADP
can-1683	239	45	balloon	balloon	NOUN
can-1683	239	46	catheter	catheter	NOUN
can-1683	239	47	.	.	PUNCT
can-1683	240	1	according	accord	VERB
can-1683	240	2	to	to	ADP
can-1683	240	3	the	the	DET
can-1683	240	4	findings	finding	NOUN
can-1683	240	5	,	,	PUNCT
can-1683	240	6	the	the	DET
can-1683	240	7	nanoparticles	nanoparticle	NOUN
can-1683	240	8	dramatically	dramatically	ADV
can-1683	240	9	decreased	decrease	VERB
can-1683	240	10	intimal	intimal	ADJ
can-1683	240	11	vsmc	vsmc	NOUN
can-1683	240	12	pcna	pcna	NOUN
can-1683	240	13	and	and	CCONJ
can-1683	240	14	pdgf	pdgf	ADJ
can-1683	240	15	-	-	PUNCT
can-1683	240	16	b	b	NOUN
can-1683	240	17	mrna	mrna	NOUN
can-1683	240	18	expressions	expression	NOUN
can-1683	240	19	as	as	ADV
can-1683	240	20	well	well	ADV
can-1683	240	21	as	as	ADP
can-1683	240	22	local	local	ADJ
can-1683	240	23	intimal	intimal	ADJ
can-1683	240	24	thickness	thickness	NOUN
can-1683	240	25	and	and	CCONJ
can-1683	240	26	area	area	NOUN
can-1683	240	27	when	when	SCONJ
can-1683	240	28	applied	apply	VERB
can-1683	240	29	to	to	ADP
can-1683	240	30	cells	cell	NOUN
can-1683	240	31	.	.	PUNCT
can-1683	241	1	the	the	DET
can-1683	241	2	infarcted	infarcted	ADJ
can-1683	241	3	myocardium	myocardium	NOUN
can-1683	241	4	expresses	express	VERB
can-1683	241	5	considerably	considerably	ADV
can-1683	241	6	more	more	ADV
can-1683	241	7	nox2	nox2	NOUN
can-1683	241	8	-	-	PUNCT
can-1683	241	9	nadph	nadph	ADJ
can-1683	241	10	.	.	PUNCT
can-1683	242	1	nox2	nox2	PROPN
can-1683	242	2	-	-	PUNCT
can-1683	242	3	sirna	sirna	PROPN
can-1683	242	4	was	be	AUX
can-1683	242	5	delivered	deliver	VERB
can-1683	242	6	to	to	ADP
can-1683	242	7	the	the	DET
can-1683	242	8	post	post	ADJ
can-1683	242	9	-	-	ADJ
can-1683	242	10	mi	mi	ADJ
can-1683	242	11	heart	heart	NOUN
can-1683	242	12	via	via	ADP
can-1683	242	13	acid	acid	NOUN
can-1683	242	14	-	-	PUNCT
can-1683	242	15	degradable	degradable	NOUN
can-1683	242	16	polyketal	polyketal	ADJ
can-1683	242	17	particles[57	particles[57	NOUN
can-1683	242	18	]	]	PUNCT
can-1683	242	19	,	,	PUNCT
can-1683	242	20	which	which	PRON
can-1683	242	21	decreased	decrease	VERB
can-1683	242	22	both	both	DET
can-1683	242	23	sirna	sirna	PROPN
can-1683	242	24	degradation	degradation	NOUN
can-1683	242	25	and	and	CCONJ
can-1683	242	26	inflammation	inflammation	NOUN
can-1683	242	27	.	.	PUNCT
can-1683	243	1	sirna	sirna	PROPN
can-1683	243	2	can	can	AUX
can-1683	243	3	be	be	AUX
can-1683	243	4	delivered	deliver	VERB
can-1683	243	5	to	to	ADP
can-1683	243	6	the	the	DET
can-1683	243	7	proper	proper	ADJ
can-1683	243	8	cells	cell	NOUN
can-1683	243	9	at	at	ADP
can-1683	243	10	the	the	DET
can-1683	243	11	right	right	ADJ
can-1683	243	12	time	time	NOUN
can-1683	243	13	in	in	ADP
can-1683	243	14	nano	nano	NOUN
can-1683	243	15	-	-	PUNCT
can-1683	243	16	doses	dose	NOUN
can-1683	243	17	created	create	VERB
can-1683	243	18	by	by	ADP
can-1683	243	19	several	several	ADJ
can-1683	243	20	pharmaceutical	pharmaceutical	ADJ
can-1683	243	21	firms	firm	NOUN
can-1683	243	22	.	.	PUNCT
can-1683	244	1	alnylam	alnylam	PROPN
can-1683	244	2	pharmaceuticals	pharmaceuticals	PROPN
can-1683	244	3	’	'	PUNCT
can-1683	244	4	aln	aln	PROPN
can-1683	244	5	-	-	PUNCT
can-1683	244	6	pcs	pc	NOUN
can-1683	244	7	or	or	CCONJ
can-1683	244	8	placebo	placebo	NOUN
can-1683	244	9	were	be	AUX
can-1683	244	10	given	give	VERB
can-1683	244	11	intravenously	intravenously	ADV
can-1683	244	12	into	into	ADP
can-1683	244	13	healthy	healthy	ADJ
can-1683	244	14	individuals	individual	NOUN
can-1683	244	15	with	with	ADP
can-1683	244	16	serum	serum	NOUN
can-1683	244	17	ldl	ldl	NOUN
can-1683	244	18	values	value	NOUN
can-1683	244	19	of	of	ADP
can-1683	244	20	3	3	NUM
can-1683	244	21	mmol	mmol	NOUN
can-1683	244	22	/	/	SYM
can-1683	244	23	l	l	NOUN
can-1683	244	24	or	or	CCONJ
can-1683	244	25	higher[58	higher[58	NOUN
can-1683	244	26	]	]	PUNCT
can-1683	244	27	.	.	PUNCT
can-1683	245	1	a	a	DET
can-1683	245	2	sirna	sirna	PROPN
can-1683	245	3	,	,	PUNCT
can-1683	245	4	aln	aln	PROPN
can-1683	245	5	-	-	PUNCT
can-1683	245	6	pcs	pcs	PROPN
can-1683	245	7	,	,	PUNCT
can-1683	245	8	is	be	AUX
can-1683	245	9	integrated	integrate	VERB
can-1683	245	10	in	in	ADP
can-1683	245	11	lipid	lipid	NOUN
can-1683	245	12	nanoparticles	nanoparticle	NOUN
can-1683	245	13	to	to	PART
can-1683	245	14	block	block	VERB
can-1683	245	15	pcsk9	pcsk9	PROPN
can-1683	245	16	production	production	NOUN
can-1683	245	17	.	.	PUNCT
can-1683	246	1	a	a	DET
can-1683	246	2	single	single	ADJ
can-1683	246	3	intravenous	intravenous	ADJ
can-1683	246	4	injection	injection	NOUN
can-1683	246	5	of	of	ADP
can-1683	246	6	aln	aln	PROPN
can-1683	246	7	-	-	PUNCT
can-1683	246	8	pcs	pc	NOUN
can-1683	246	9	decreased	decrease	VERB
can-1683	246	10	human	human	ADJ
can-1683	246	11	pcsk9	pcsk9	NOUN
can-1683	246	12	protein	protein	NOUN
can-1683	246	13	levels	level	NOUN
can-1683	246	14	by	by	ADP
can-1683	246	15	70	70	NUM
can-1683	246	16	%	%	NOUN
can-1683	246	17	,	,	PUNCT
can-1683	246	18	while	while	SCONJ
can-1683	246	19	ldl	ldl	NOUN
can-1683	246	20	was	be	AUX
can-1683	246	21	lowered	lower	VERB
can-1683	246	22	by	by	ADP
can-1683	246	23	40	40	NUM
can-1683	246	24	%	%	NOUN
can-1683	246	25	.	.	PUNCT
can-1683	247	1	using	use	VERB
can-1683	247	2	a	a	DET
can-1683	247	3	combination	combination	NOUN
can-1683	247	4	of	of	ADP
can-1683	247	5	nanotechnology	nanotechnology	NOUN
can-1683	247	6	,	,	PUNCT
can-1683	247	7	gene	gene	NOUN
can-1683	247	8	interference	interference	NOUN
can-1683	247	9	technology	technology	NOUN
can-1683	247	10	,	,	PUNCT
can-1683	247	11	and	and	CCONJ
can-1683	247	12	the	the	DET
can-1683	247	13	packaged	package	VERB
can-1683	247	14	chemicals	chemical	NOUN
can-1683	247	15	,	,	PUNCT
can-1683	247	16	the	the	DET
can-1683	247	17	therapeutic	therapeutic	ADJ
can-1683	247	18	impact	impact	NOUN
can-1683	247	19	is	be	AUX
can-1683	247	20	far	far	ADV
can-1683	247	21	superior	superior	ADJ
can-1683	247	22	than	than	ADP
can-1683	247	23	a	a	DET
can-1683	247	24	single	single	ADJ
can-1683	247	25	therapy	therapy	NOUN
can-1683	247	26	due	due	ADP
can-1683	247	27	to	to	ADP
can-1683	247	28	the	the	DET
can-1683	247	29	synergistic	synergistic	ADJ
can-1683	247	30	effect	effect	NOUN
can-1683	247	31	.	.	PUNCT
can-1683	248	1	a	a	DET
can-1683	248	2	medicine	medicine	NOUN
can-1683	248	3	called	call	VERB
can-1683	248	4	carvedilol	carvedilol	PROPN
can-1683	248	5	,	,	PUNCT
can-1683	248	6	which	which	PRON
can-1683	248	7	inhibits	inhibit	VERB
can-1683	248	8	adrenergic	adrenergic	ADJ
can-1683	248	9	19	19	NUM
can-1683	248	10	receptors	receptor	NOUN
can-1683	248	11	in	in	ADP
can-1683	248	12	several	several	ADJ
can-1683	248	13	organs	organ	NOUN
can-1683	248	14	concurrently	concurrently	ADV
can-1683	248	15	,	,	PUNCT
can-1683	248	16	is	be	AUX
can-1683	248	17	extensively	extensively	ADV
can-1683	248	18	used	use	VERB
can-1683	248	19	and	and	CCONJ
can-1683	248	20	effective	effective	ADJ
can-1683	248	21	.	.	PUNCT
can-1683	249	1	cardiovascular	cardiovascular	ADJ
can-1683	249	2	hypertrophy	hypertrophy	NOUN
can-1683	249	3	can	can	AUX
can-1683	249	4	be	be	AUX
can-1683	249	5	effectively	effectively	ADV
can-1683	249	6	prevented	prevent	VERB
can-1683	249	7	by	by	ADP
can-1683	249	8	silencing	silence	VERB
can-1683	249	9	p53	p53	NOUN
can-1683	249	10	in	in	ADP
can-1683	249	11	the	the	DET
can-1683	249	12	dna	dna	NOUN
can-1683	249	13	.	.	PUNCT
can-1683	250	1	however	however	ADV
can-1683	250	2	,	,	PUNCT
can-1683	250	3	cancer	cancer	NOUN
can-1683	250	4	can	can	AUX
can-1683	250	5	spread	spread	VERB
can-1683	250	6	to	to	ADP
can-1683	250	7	other	other	ADJ
can-1683	250	8	organs	organ	NOUN
can-1683	250	9	as	as	ADP
can-1683	250	10	a	a	DET
can-1683	250	11	result	result	NOUN
can-1683	250	12	.	.	PUNCT
can-1683	251	1	these	these	DET
can-1683	251	2	bioactive	bioactive	ADJ
can-1683	251	3	compounds	compound	NOUN
can-1683	251	4	were	be	AUX
can-1683	251	5	successfully	successfully	ADV
can-1683	251	6	encapsulated	encapsulate	VERB
can-1683	251	7	with	with	ADP
can-1683	251	8	stearic	stearic	ADJ
can-1683	251	9	acid	acid	NOUN
can-1683	251	10	modified	modify	VERB
can-1683	251	11	carboxymethyl	carboxymethyl	NOUN
can-1683	251	12	chitosan	chitosan	NOUN
can-1683	251	13	(	(	PUNCT
can-1683	251	14	cmc	cmc	NOUN
can-1683	251	15	)	)	PUNCT
can-1683	251	16	nanopolymers	nanopolymer	NOUN
can-1683	251	17	linked	link	VERB
can-1683	251	18	to	to	ADP
can-1683	251	19	a	a	DET
can-1683	251	20	homing	homing	NOUN
can-1683	251	21	peptide	peptide	NOUN
can-1683	251	22	for	for	ADP
can-1683	251	23	distribution	distribution	NOUN
can-1683	251	24	in	in	ADP
can-1683	251	25	vivo	vivo	NOUN
can-1683	251	26	to	to	ADP
can-1683	251	27	hypertrophied	hypertrophied	ADJ
can-1683	251	28	cardiomyocytes	cardiomyocyte	NOUN
can-1683	251	29	.	.	PUNCT
can-1683	252	1	10	10	NUM
can-1683	252	2	.	.	PUNCT
can-1683	253	1	safety	safety	NOUN
can-1683	253	2	of	of	ADP
can-1683	253	3	the	the	DET
can-1683	253	4	nddss	nddss	NOUN
can-1683	253	5	although	although	SCONJ
can-1683	253	6	nanomaterial	nanomaterial	ADJ
can-1683	253	7	nddss	nddss	NOUN
can-1683	253	8	are	be	AUX
can-1683	253	9	becoming	become	VERB
can-1683	253	10	more	more	ADV
can-1683	253	11	common	common	ADJ
can-1683	253	12	,	,	PUNCT
can-1683	253	13	their	their	PRON
can-1683	253	14	unknown	unknown	ADJ
can-1683	253	15	toxicity	toxicity	NOUN
can-1683	253	16	and	and	CCONJ
can-1683	253	17	lack	lack	NOUN
can-1683	253	18	of	of	ADP
can-1683	253	19	systematic	systematic	ADJ
can-1683	253	20	research	research	NOUN
can-1683	253	21	into	into	ADP
can-1683	253	22	the	the	DET
can-1683	253	23	materials	material	NOUN
can-1683	253	24	themselves	themselves	PRON
can-1683	253	25	limit	limit	VERB
can-1683	253	26	their	their	PRON
can-1683	253	27	continued	continue	VERB
can-1683	253	28	use	use	NOUN
can-1683	253	29	.	.	PUNCT
can-1683	254	1	the	the	DET
can-1683	254	2	surface	surface	NOUN
can-1683	254	3	effect	effect	NOUN
can-1683	254	4	,	,	PUNCT
can-1683	254	5	small	small	ADJ
can-1683	254	6	scale	scale	NOUN
can-1683	254	7	effect	effect	NOUN
can-1683	254	8	,	,	PUNCT
can-1683	254	9	quantum	quantum	ADJ
can-1683	254	10	scale	scale	NOUN
can-1683	254	11	effect	effect	NOUN
can-1683	254	12	,	,	PUNCT
can-1683	254	13	and	and	CCONJ
can-1683	254	14	macroscopical	macroscopical	ADJ
can-1683	254	15	quantum	quantum	ADJ
can-1683	254	16	tunnelling	tunnelling	NOUN
can-1683	254	17	effect	effect	NOUN
can-1683	254	18	will	will	AUX
can-1683	254	19	all	all	PRON
can-1683	254	20	become	become	VERB
can-1683	254	21	apparent	apparent	ADJ
can-1683	254	22	when	when	SCONJ
can-1683	254	23	the	the	DET
can-1683	254	24	particle	particle	NOUN
can-1683	254	25	size	size	NOUN
can-1683	254	26	reaches	reach	VERB
can-1683	254	27	the	the	DET
can-1683	254	28	nanoscale	nanoscale	NOUN
can-1683	254	29	scale[59	scale[59	PROPN
can-1683	254	30	]	]	PUNCT
can-1683	254	31	.	.	PUNCT
can-1683	255	1	only	only	ADV
can-1683	255	2	a	a	DET
can-1683	255	3	few	few	ADJ
can-1683	255	4	research	research	NOUN
can-1683	255	5	have	have	AUX
can-1683	255	6	looked	look	VERB
can-1683	255	7	at	at	ADP
can-1683	255	8	the	the	DET
can-1683	255	9	potential	potential	ADJ
can-1683	255	10	dangers	danger	NOUN
can-1683	255	11	of	of	ADP
can-1683	255	12	ndds	ndd	NOUN
can-1683	255	13	on	on	ADP
can-1683	255	14	the	the	DET
can-1683	255	15	cardiovascular	cardiovascular	ADJ
can-1683	255	16	system	system	NOUN
can-1683	255	17	.	.	PUNCT
can-1683	256	1	because	because	SCONJ
can-1683	256	2	of	of	ADP
can-1683	256	3	this	this	PRON
can-1683	256	4	,	,	PUNCT
can-1683	256	5	cardiovascular	cardiovascular	ADJ
can-1683	256	6	system	system	NOUN
can-1683	256	7	tissue	tissue	NOUN
can-1683	256	8	has	have	AUX
can-1683	256	9	been	be	AUX
can-1683	256	10	identified	identify	VERB
can-1683	256	11	as	as	ADP
can-1683	256	12	a	a	DET
can-1683	256	13	primary	primary	ADJ
can-1683	256	14	nddss	nddss	NOUN
can-1683	256	15	target	target	NOUN
can-1683	256	16	,	,	PUNCT
can-1683	256	17	which	which	PRON
can-1683	256	18	can	can	AUX
can-1683	256	19	have	have	VERB
can-1683	256	20	a	a	DET
can-1683	256	21	significant	significant	ADJ
can-1683	256	22	influence	influence	NOUN
can-1683	256	23	on	on	ADP
can-1683	256	24	illness	illness	NOUN
can-1683	256	25	prognosis	prognosis	NOUN
can-1683	256	26	.	.	PUNCT
can-1683	257	1	nanomaterials	nanomaterial	NOUN
can-1683	257	2	have	have	AUX
can-1683	257	3	been	be	AUX
can-1683	257	4	shown	show	VERB
can-1683	257	5	to	to	PART
can-1683	257	6	enter	enter	VERB
can-1683	257	7	the	the	DET
can-1683	257	8	bloodstream	bloodstream	NOUN
can-1683	257	9	via	via	ADP
can-1683	257	10	the	the	DET
can-1683	257	11	respiratory	respiratory	ADJ
can-1683	257	12	,	,	PUNCT
can-1683	257	13	digestive	digestive	ADJ
can-1683	257	14	,	,	PUNCT
can-1683	257	15	skin	skin	NOUN
can-1683	257	16	,	,	PUNCT
can-1683	257	17	and	and	CCONJ
can-1683	257	18	other	other	ADJ
can-1683	257	19	mucous	mucous	ADJ
can-1683	257	20	membranes	membrane	NOUN
can-1683	257	21	,	,	PUNCT
can-1683	257	22	where	where	SCONJ
can-1683	257	23	they	they	PRON
can-1683	257	24	interact	interact	VERB
can-1683	257	25	with	with	ADP
can-1683	257	26	the	the	DET
can-1683	257	27	blood	blood	NOUN
can-1683	257	28	,	,	PUNCT
can-1683	257	29	immune	immune	ADJ
can-1683	257	30	system	system	NOUN
can-1683	257	31	,	,	PUNCT
can-1683	257	32	and	and	CCONJ
can-1683	257	33	other	other	ADJ
can-1683	257	34	tissues	tissue	NOUN
can-1683	257	35	,	,	PUNCT
can-1683	257	36	including	include	VERB
can-1683	257	37	plasma	plasma	NOUN
can-1683	257	38	proteins	protein	NOUN
can-1683	257	39	and	and	CCONJ
can-1683	257	40	immune	immune	ADJ
can-1683	257	41	proteins	protein	NOUN
can-1683	257	42	,	,	PUNCT
can-1683	257	43	blood	blood	NOUN
can-1683	257	44	cells	cell	NOUN
can-1683	257	45	and	and	CCONJ
can-1683	257	46	immune	immune	ADJ
can-1683	257	47	cells	cell	NOUN
can-1683	257	48	,	,	PUNCT
can-1683	257	49	and	and	CCONJ
can-1683	257	50	so	so	ADV
can-1683	257	51	on	on	ADV
can-1683	257	52	.	.	PUNCT
can-1683	258	1	toxicological	toxicological	ADJ
can-1683	258	2	studies	study	NOUN
can-1683	258	3	of	of	ADP
can-1683	258	4	the	the	DET
can-1683	258	5	health	health	NOUN
can-1683	258	6	effects	effect	NOUN
can-1683	258	7	are	be	AUX
can-1683	258	8	the	the	DET
can-1683	258	9	primary	primary	ADJ
can-1683	258	10	focus	focus	NOUN
can-1683	258	11	of	of	ADP
can-1683	258	12	the	the	DET
can-1683	258	13	ndds	ndd	NOUN
can-1683	258	14	safety	safety	NOUN
can-1683	258	15	evaluation	evaluation	NOUN
can-1683	258	16	.	.	PUNCT
can-1683	259	1	nanomaterials	nanomaterial	NOUN
can-1683	259	2	’	'	PUNCT
can-1683	259	3	cardiovascular	cardiovascular	ADJ
can-1683	259	4	toxicity	toxicity	NOUN
can-1683	259	5	has	have	AUX
can-1683	259	6	been	be	AUX
can-1683	259	7	linked	link	VERB
can-1683	259	8	to	to	ADP
can-1683	259	9	a	a	DET
can-1683	259	10	number	number	NOUN
can-1683	259	11	of	of	ADP
can-1683	259	12	adverse	adverse	ADJ
can-1683	259	13	consequences	consequence	NOUN
can-1683	259	14	,	,	PUNCT
can-1683	259	15	including	include	VERB
can-1683	259	16	oxidative	oxidative	ADJ
can-1683	259	17	stress	stress	NOUN
can-1683	259	18	,	,	PUNCT
can-1683	259	19	inflammation	inflammation	NOUN
can-1683	259	20	,	,	PUNCT
can-1683	259	21	apoptosis	apoptosis	NOUN
can-1683	259	22	,	,	PUNCT
can-1683	259	23	blood	blood	NOUN
can-1683	259	24	aggregation	aggregation	NOUN
can-1683	259	25	,	,	PUNCT
can-1683	259	26	and	and	CCONJ
can-1683	259	27	cardiac	cardiac	ADJ
can-1683	259	28	signal	signal	NOUN
can-1683	259	29	transduction	transduction	NOUN
can-1683	259	30	,	,	PUNCT
can-1683	259	31	in	in	ADP
can-1683	259	32	animal	animal	NOUN
can-1683	259	33	and	and	CCONJ
can-1683	259	34	cell	cell	NOUN
can-1683	259	35	studies[60	studies[60	NOUN
can-1683	259	36	]	]	PUNCT
can-1683	259	37	.	.	PUNCT
can-1683	260	1	inflammation	inflammation	NOUN
can-1683	260	2	and	and	CCONJ
can-1683	260	3	oxidative	oxidative	ADJ
can-1683	260	4	stress	stress	NOUN
can-1683	260	5	are	be	AUX
can-1683	260	6	two	two	NUM
can-1683	260	7	of	of	ADP
can-1683	260	8	the	the	DET
can-1683	260	9	most	most	ADV
can-1683	260	10	important	important	ADJ
can-1683	260	11	pathways	pathway	NOUN
can-1683	260	12	for	for	ADP
can-1683	260	13	cardiovascular	cardiovascular	ADJ
can-1683	260	14	damage	damage	NOUN
can-1683	260	15	caused	cause	VERB
can-1683	260	16	by	by	ADP
can-1683	260	17	nanomaterials	nanomaterial	NOUN
can-1683	260	18	,	,	PUNCT
can-1683	260	19	according	accord	VERB
can-1683	260	20	to	to	ADP
can-1683	260	21	this	this	DET
can-1683	260	22	research	research	NOUN
can-1683	260	23	.	.	PUNCT
can-1683	261	1	hypertension	hypertension	NOUN
can-1683	261	2	,	,	PUNCT
can-1683	261	3	myocarditis	myocarditis	PROPN
can-1683	261	4	,	,	PUNCT
can-1683	261	5	as	as	ADP
can-1683	261	6	,	,	PUNCT
can-1683	261	7	acute	acute	ADJ
can-1683	261	8	myocardial	myocardial	ADJ
can-1683	261	9	infarction	infarction	NOUN
can-1683	261	10	,	,	PUNCT
can-1683	261	11	and	and	CCONJ
can-1683	261	12	heart	heart	NOUN
can-1683	261	13	failure	failure	NOUN
can-1683	261	14	can	can	AUX
can-1683	261	15	all	all	PRON
can-1683	261	16	be	be	AUX
can-1683	261	17	exacerbated	exacerbate	VERB
can-1683	261	18	by	by	ADP
can-1683	261	19	an	an	DET
can-1683	261	20	inflammatory	inflammatory	ADJ
can-1683	261	21	response	response	NOUN
can-1683	261	22	to	to	ADP
can-1683	261	23	a	a	DET
can-1683	261	24	variety	variety	NOUN
can-1683	261	25	of	of	ADP
can-1683	261	26	factors	factor	NOUN
can-1683	261	27	.	.	PUNCT
can-1683	262	1	when	when	SCONJ
can-1683	262	2	nano	nano	NOUN
can-1683	262	3	-	-	PUNCT
can-1683	262	4	carriers	carrier	NOUN
can-1683	262	5	are	be	AUX
can-1683	262	6	not	not	PART
can-1683	262	7	removed	remove	VERB
can-1683	262	8	in	in	ADP
can-1683	262	9	a	a	DET
can-1683	262	10	timely	timely	ADJ
can-1683	262	11	manner	manner	NOUN
can-1683	262	12	,	,	PUNCT
can-1683	262	13	they	they	PRON
can-1683	262	14	can	can	AUX
can-1683	262	15	reach	reach	VERB
can-1683	262	16	all	all	DET
can-1683	262	17	organs	organ	NOUN
can-1683	262	18	via	via	ADP
can-1683	262	19	blood	blood	NOUN
can-1683	262	20	,	,	PUNCT
can-1683	262	21	triggering	trigger	VERB
can-1683	262	22	a	a	DET
can-1683	262	23	sequence	sequence	NOUN
can-1683	262	24	of	of	ADP
can-1683	262	25	cytokines	cytokine	NOUN
can-1683	262	26	,	,	PUNCT
can-1683	262	27	which	which	PRON
can-1683	262	28	in	in	ADP
can-1683	262	29	turn	turn	NOUN
can-1683	262	30	raises	raise	VERB
can-1683	262	31	the	the	DET
can-1683	262	32	risk	risk	NOUN
can-1683	262	33	of	of	ADP
can-1683	262	34	cardiovascular	cardiovascular	ADJ
can-1683	262	35	events	event	NOUN
can-1683	262	36	if	if	SCONJ
can-1683	262	37	they	they	PRON
can-1683	262	38	are	be	AUX
can-1683	262	39	n’t	not	PART
can-1683	262	40	eliminated[61	eliminated[61	PROPN
can-1683	262	41	]	]	X
can-1683	262	42	.	.	PUNCT
can-1683	263	1	as	as	ADP
can-1683	263	2	a	a	DET
can-1683	263	3	result	result	NOUN
can-1683	263	4	of	of	ADP
can-1683	263	5	nanomaterials	nanomaterial	NOUN
can-1683	263	6	’	'	PUNCT
can-1683	263	7	many	many	ADJ
can-1683	263	8	surface	surface	NOUN
can-1683	263	9	atoms	atom	NOUN
can-1683	263	10	and	and	CCONJ
can-1683	263	11	high	high	ADJ
can-1683	263	12	reactivity	reactivity	NOUN
can-1683	263	13	,	,	PUNCT
can-1683	263	14	free	free	ADJ
can-1683	263	15	radicals	radical	NOUN
can-1683	263	16	and	and	CCONJ
can-1683	263	17	reactive	reactive	ADJ
can-1683	263	18	oxygen	oxygen	NOUN
can-1683	263	19	species	specie	NOUN
can-1683	263	20	(	(	PUNCT
can-1683	263	21	ros	ros	PROPN
can-1683	263	22	)	)	PUNCT
can-1683	263	23	can	can	AUX
can-1683	263	24	be	be	AUX
can-1683	263	25	generated	generate	VERB
can-1683	263	26	,	,	PUNCT
can-1683	263	27	posing	pose	VERB
can-1683	263	28	a	a	DET
can-1683	263	29	threat	threat	NOUN
can-1683	263	30	to	to	PART
can-1683	263	31	antioxidant	antioxidant	VERB
can-1683	263	32	systems[62	systems[62	NOUN
can-1683	263	33	]	]	PUNCT
can-1683	263	34	.	.	PUNCT
can-1683	264	1	dna	dna	PROPN
can-1683	264	2	and	and	CCONJ
can-1683	264	3	proteins	protein	NOUN
can-1683	264	4	,	,	PUNCT
can-1683	264	5	which	which	PRON
can-1683	264	6	are	be	AUX
can-1683	264	7	macromolecular	macromolecular	ADJ
can-1683	264	8	molecules	molecule	NOUN
can-1683	264	9	,	,	PUNCT
can-1683	264	10	can	can	AUX
can-1683	264	11	be	be	AUX
can-1683	264	12	damaged	damage	VERB
can-1683	264	13	by	by	ADP
can-1683	264	14	oxidative	oxidative	ADJ
can-1683	264	15	stress	stress	NOUN
can-1683	264	16	,	,	PUNCT
can-1683	264	17	resulting	result	VERB
can-1683	264	18	in	in	ADP
can-1683	264	19	decreased	decrease	VERB
can-1683	264	20	cell	cell	NOUN
can-1683	264	21	development	development	NOUN
can-1683	264	22	,	,	PUNCT
can-1683	264	23	irregularities	irregularity	NOUN
can-1683	264	24	in	in	ADP
can-1683	264	25	the	the	DET
can-1683	264	26	cell	cell	NOUN
can-1683	264	27	cycle	cycle	NOUN
can-1683	264	28	,	,	PUNCT
can-1683	264	29	and	and	CCONJ
can-1683	264	30	even	even	ADV
can-1683	264	31	cell	cell	NOUN
can-1683	264	32	death	death	NOUN
can-1683	264	33	.	.	PUNCT
can-1683	265	1	caenorhabditis	caenorhabditis	PROPN
can-1683	265	2	elegans	elegans	PROPN
can-1683	265	3	was	be	AUX
can-1683	265	4	used	use	VERB
can-1683	265	5	to	to	PART
can-1683	265	6	test	test	VERB
can-1683	265	7	the	the	DET
can-1683	265	8	biological	biological	ADJ
can-1683	265	9	safety	safety	NOUN
can-1683	265	10	of	of	ADP
can-1683	265	11	ph	ph	ADJ
can-1683	265	12	-	-	PUNCT
can-1683	265	13	responsive	responsive	ADJ
can-1683	265	14	carrier	carrier	NOUN
can-1683	265	15	system	system	NOUN
can-1683	265	16	(	(	PUNCT
can-1683	265	17	ffpff	ffpff	ADV
can-1683	265	18	self	self	NOUN
can-1683	265	19	-	-	PUNCT
can-1683	265	20	assembling	assembling	NOUN
can-1683	265	21	into	into	ADP
can-1683	265	22	a	a	DET
can-1683	265	23	nanosphere	nanosphere	NOUN
can-1683	265	24	structure	structure	NOUN
can-1683	265	25	,	,	PUNCT
can-1683	265	26	ffpff	ffpff	PROPN
can-1683	265	27	nps	nps	PROPN
can-1683	265	28	)	)	PUNCT
can-1683	265	29	,	,	PUNCT
can-1683	265	30	which	which	PRON
can-1683	265	31	was	be	AUX
can-1683	265	32	designed	design	VERB
can-1683	265	33	for	for	ADP
can-1683	265	34	anti	anti	ADJ
can-1683	265	35	-	-	ADJ
can-1683	265	36	tumor	tumor	ADJ
can-1683	265	37	drug	drug	NOUN
can-1683	265	38	delivery	delivery	NOUN
can-1683	265	39	and	and	CCONJ
can-1683	265	40	the	the	DET
can-1683	265	41	results	result	NOUN
can-1683	265	42	showed	show	VERB
can-1683	265	43	that	that	DET
can-1683	265	44	exposure	exposure	NOUN
can-1683	265	45	to	to	ADP
can-1683	265	46	high	high	ADJ
can-1683	265	47	doses	dose	NOUN
can-1683	265	48	of	of	ADP
can-1683	265	49	ffpff	ffpff	PROPN
can-1683	265	50	nps	nps	PROPN
can-1683	265	51	did	do	AUX
can-1683	265	52	not	not	PART
can-1683	265	53	have	have	VERB
can-1683	265	54	a	a	DET
can-1683	265	55	significant	significant	ADJ
can-1683	265	56	impact	impact	NOUN
can-1683	265	57	on	on	ADP
can-1683	265	58	the	the	DET
can-1683	265	59	survival	survival	NOUN
can-1683	265	60	rate	rate	NOUN
can-1683	265	61	,	,	PUNCT
can-1683	265	62	growth	growth	NOUN
can-1683	265	63	,	,	PUNCT
can-1683	265	64	development	development	NOUN
can-1683	265	65	,	,	PUNCT
can-1683	265	66	movement	movement	NOUN
can-1683	265	67	,	,	PUNCT
can-1683	265	68	and	and	CCONJ
can-1683	265	69	reproduction	reproduction	NOUN
can-1683	265	70	of	of	ADP
can-1683	265	71	caenorhabditis	caenorhabditis	PROPN
can-1683	265	72	elegans	elegan	NOUN
can-1683	265	73	.	.	PUNCT
can-1683	266	1	the	the	DET
can-1683	266	2	preliminary	preliminary	ADJ
can-1683	266	3	evaluation	evaluation	NOUN
can-1683	266	4	of	of	ADP
can-1683	266	5	the	the	DET
can-1683	266	6	overall	overall	ADJ
can-1683	266	7	biological	biological	ADJ
can-1683	266	8	model	model	NOUN
can-1683	266	9	of	of	ADP
can-1683	266	10	caenorhabditis	caenorhabditis	PROPN
can-1683	266	11	elegans	elegans	PROPN
can-1683	266	12	shows	show	VERB
can-1683	266	13	that	that	SCONJ
can-1683	266	14	ffpff	ffpff	PROPN
can-1683	266	15	nps	nps	PROPN
can-1683	266	16	has	have	VERB
can-1683	266	17	good	good	ADJ
can-1683	266	18	biological	biological	ADJ
can-1683	266	19	safety[63	safety[63	NOUN
can-1683	266	20	]	]	PUNCT
can-1683	266	21	.	.	PUNCT
can-1683	267	1	potential	potential	ADJ
can-1683	267	2	toxicities	toxicity	NOUN
can-1683	267	3	that	that	PRON
can-1683	267	4	are	be	AUX
can-1683	267	5	associated	associate	VERB
can-1683	267	6	with	with	ADP
can-1683	267	7	nanocarriers	nanocarrier	NOUN
can-1683	267	8	,	,	PUNCT
can-1683	267	9	mechanisms	mechanism	NOUN
can-1683	267	10	of	of	ADP
can-1683	267	11	toxicity	toxicity	NOUN
can-1683	267	12	,	,	PUNCT
can-1683	267	13	major	major	ADJ
can-1683	267	14	target	target	NOUN
can-1683	267	15	organs	organ	NOUN
can-1683	267	16	,	,	PUNCT
can-1683	267	17	and	and	CCONJ
can-1683	267	18	factors	factor	NOUN
can-1683	267	19	influencing	influence	VERB
can-1683	267	20	these	these	DET
can-1683	267	21	toxicities	toxicity	NOUN
can-1683	267	22	have	have	AUX
can-1683	267	23	also	also	ADV
can-1683	267	24	been	be	AUX
can-1683	267	25	discussed[64	discussed[64	ADV
can-1683	267	26	]	]	X
can-1683	267	27	.	.	PUNCT
can-1683	268	1	nanoparticles	nanoparticle	NOUN
can-1683	268	2	,	,	PUNCT
can-1683	268	3	due	due	ADP
can-1683	268	4	to	to	ADP
can-1683	268	5	their	their	PRON
can-1683	268	6	nanosize	nanosize	NOUN
can-1683	268	7	,	,	PUNCT
can-1683	268	8	easily	easily	ADV
can-1683	268	9	traverse	traverse	VERB
can-1683	268	10	through	through	ADP
can-1683	268	11	biological	biological	ADJ
can-1683	268	12	barriers	barrier	NOUN
can-1683	268	13	and	and	CCONJ
can-1683	268	14	may	may	AUX
can-1683	268	15	be	be	AUX
can-1683	268	16	accumulated	accumulate	VERB
can-1683	268	17	in	in	ADP
can-1683	268	18	the	the	DET
can-1683	268	19	body	body	NOUN
can-1683	268	20	,	,	PUNCT
can-1683	268	21	where	where	SCONJ
can-1683	268	22	the	the	DET
can-1683	268	23	ingredients	ingredient	NOUN
can-1683	268	24	incorporated	incorporate	VERB
can-1683	268	25	in	in	ADP
can-1683	268	26	the	the	DET
can-1683	268	27	formulation	formulation	NOUN
can-1683	268	28	development	development	NOUN
can-1683	268	29	might	might	AUX
can-1683	268	30	accumulate	accumulate	VERB
can-1683	268	31	and/or	and/or	CCONJ
can-1683	268	32	produce	produce	VERB
can-1683	268	33	toxic	toxic	ADJ
can-1683	268	34	manifestation	manifestation	NOUN
can-1683	268	35	,	,	PUNCT
can-1683	268	36	leading	lead	VERB
can-1683	268	37	to	to	PART
can-1683	268	38	cause	cause	VERB
can-1683	268	39	severe	severe	ADJ
can-1683	268	40	health	health	NOUN
can-1683	268	41	hazards	hazard	NOUN
can-1683	268	42	.	.	PUNCT
can-1683	269	1	therefore	therefore	ADV
can-1683	269	2	,	,	PUNCT
can-1683	269	3	the	the	DET
can-1683	269	4	toxic	toxic	ADJ
can-1683	269	5	profile	profile	NOUN
can-1683	269	6	of	of	ADP
can-1683	269	7	these	these	DET
can-1683	269	8	delivery	delivery	NOUN
can-1683	269	9	systems	system	NOUN
can-1683	269	10	needs	need	VERB
can-1683	269	11	to	to	PART
can-1683	269	12	be	be	AUX
can-1683	269	13	evaluated	evaluate	VERB
can-1683	269	14	at	at	ADP
can-1683	269	15	the	the	DET
can-1683	269	16	molecular	molecular	ADJ
can-1683	269	17	,	,	PUNCT
can-1683	269	18	cellular	cellular	ADJ
can-1683	269	19	,	,	PUNCT
can-1683	269	20	tissue	tissue	NOUN
can-1683	269	21	and	and	CCONJ
can-1683	269	22	organ	organ	NOUN
can-1683	269	23	level[65	level[65	PROPN
can-1683	269	24	]	]	PUNCT
can-1683	269	25	.	.	PUNCT
can-1683	270	1	the	the	DET
can-1683	270	2	research	research	NOUN
can-1683	270	3	of	of	ADP
can-1683	270	4	nanomaterial	nanomaterial	NOUN
can-1683	270	5	-	-	PUNCT
can-1683	270	6	induced	induce	VERB
can-1683	270	7	cardiovascular	cardiovascular	ADJ
can-1683	270	8	system	system	NOUN
can-1683	270	9	injury	injury	NOUN
can-1683	270	10	is	be	AUX
can-1683	270	11	still	still	ADV
can-1683	270	12	in	in	ADP
can-1683	270	13	its	its	PRON
can-1683	270	14	infancy	infancy	NOUN
can-1683	270	15	across	across	ADP
can-1683	270	16	the	the	DET
can-1683	270	17	world	world	NOUN
can-1683	270	18	.	.	PUNCT
can-1683	271	1	nanoparticle	nanoparticle	NOUN
can-1683	271	2	physicochemical	physicochemical	ADJ
can-1683	271	3	factors	factor	NOUN
can-1683	271	4	(	(	PUNCT
can-1683	271	5	shape	shape	NOUN
can-1683	271	6	,	,	PUNCT
can-1683	271	7	size	size	NOUN
can-1683	271	8	,	,	PUNCT
can-1683	271	9	size	size	NOUN
can-1683	271	10	distribution	distribution	NOUN
can-1683	271	11	,	,	PUNCT
can-1683	271	12	surface	surface	NOUN
can-1683	271	13	structure	structure	NOUN
can-1683	271	14	,	,	PUNCT
can-1683	271	15	electrochemical	electrochemical	ADJ
can-1683	271	16	properties	property	NOUN
can-1683	271	17	)	)	PUNCT
can-1683	271	18	and	and	CCONJ
can-1683	271	19	the	the	DET
can-1683	271	20	toxic	toxic	ADJ
can-1683	271	21	effects	effect	NOUN
can-1683	271	22	of	of	ADP
can-1683	271	23	the	the	DET
can-1683	271	24	cardiovascular	cardiovascular	ADJ
can-1683	271	25	system	system	NOUN
can-1683	271	26	are	be	AUX
can-1683	271	27	poorly	poorly	ADV
can-1683	271	28	understood	understand	VERB
can-1683	271	29	in	in	ADP
can-1683	271	30	terms	term	NOUN
can-1683	271	31	of	of	ADP
can-1683	271	32	their	their	PRON
can-1683	271	33	link	link	NOUN
can-1683	271	34	to	to	ADP
can-1683	271	35	the	the	DET
can-1683	271	36	physiochemical	physiochemical	ADJ
can-1683	271	37	parameters	parameter	NOUN
can-1683	271	38	.	.	PUNCT
can-1683	272	1	more	more	ADJ
can-1683	272	2	study	study	NOUN
can-1683	272	3	into	into	ADP
can-1683	272	4	the	the	DET
can-1683	272	5	cardiovascular	cardiovascular	ADJ
can-1683	272	6	system	system	NOUN
can-1683	272	7	hazardous	hazardous	ADJ
can-1683	272	8	effects	effect	NOUN
can-1683	272	9	and	and	CCONJ
can-1683	272	10	processes	process	NOUN
can-1683	272	11	of	of	ADP
can-1683	272	12	ordinary	ordinary	ADJ
can-1683	272	13	nanomaterial	nanomaterial	ADJ
can-1683	272	14	exposure	exposure	NOUN
can-1683	272	15	is	be	AUX
can-1683	272	16	therefore	therefore	ADV
can-1683	272	17	needed	need	VERB
can-1683	272	18	by	by	ADP
can-1683	272	19	scientists	scientist	NOUN
can-1683	272	20	in	in	ADP
can-1683	272	21	order	order	NOUN
can-1683	272	22	to	to	PART
can-1683	272	23	better	well	ADV
can-1683	272	24	utilise	utilise	VERB
can-1683	272	25	nanomaterials	nanomaterial	NOUN
can-1683	272	26	’	'	PUNCT
can-1683	272	27	good	good	ADJ
can-1683	272	28	properties	property	NOUN
can-1683	272	29	to	to	PART
can-1683	272	30	avoid	avoid	VERB
can-1683	272	31	,	,	PUNCT
can-1683	272	32	mitigate	mitigate	ADJ
can-1683	272	33	,	,	PUNCT
can-1683	272	34	or	or	CCONJ
can-1683	272	35	eliminate	eliminate	VERB
can-1683	272	36	potential	potential	ADJ
can-1683	272	37	detrimental	detrimental	ADJ
can-1683	272	38	health	health	NOUN
can-1683	272	39	consequences	consequence	NOUN
can-1683	272	40	.	.	PUNCT
can-1683	273	1	nanomaterial	nanomaterial	ADJ
can-1683	273	2	safety	safety	NOUN
can-1683	273	3	evalua	evalua	VERB
can-1683	273	4	20	20	NUM
can-1683	273	5	tion	tion	NOUN
can-1683	273	6	technologies	technology	NOUN
can-1683	273	7	and	and	CCONJ
can-1683	273	8	standards	standard	NOUN
can-1683	273	9	would	would	AUX
can-1683	273	10	also	also	ADV
can-1683	273	11	have	have	VERB
can-1683	273	12	theoretical	theoretical	ADJ
can-1683	273	13	and	and	CCONJ
can-1683	273	14	technological	technological	ADJ
can-1683	273	15	foundations	foundation	NOUN
can-1683	273	16	provided	provide	VERB
can-1683	273	17	by	by	ADP
can-1683	273	18	this	this	DET
can-1683	273	19	study	study	NOUN
can-1683	273	20	.	.	PUNCT
can-1683	274	1	11	11	NUM
can-1683	274	2	.	.	PUNCT
can-1683	275	1	conclusion	conclusion	NOUN
can-1683	275	2	in	in	ADP
can-1683	275	3	conclusion	conclusion	NOUN
can-1683	275	4	,	,	PUNCT
can-1683	275	5	the	the	DET
can-1683	275	6	nano	nano	NOUN
can-1683	275	7	-	-	PUNCT
can-1683	275	8	carrier	carrier	NOUN
can-1683	275	9	,	,	PUNCT
can-1683	275	10	as	as	ADP
can-1683	275	11	an	an	DET
can-1683	275	12	efficient	efficient	ADJ
can-1683	275	13	,	,	PUNCT
can-1683	275	14	specific	specific	ADJ
can-1683	275	15	and	and	CCONJ
can-1683	275	16	controllable	controllable	ADJ
can-1683	275	17	intracellular	intracellular	ADJ
can-1683	275	18	drug	drug	NOUN
can-1683	275	19	delivery	delivery	NOUN
can-1683	275	20	method	method	NOUN
can-1683	275	21	,	,	PUNCT
can-1683	275	22	has	have	AUX
can-1683	275	23	shown	show	VERB
can-1683	275	24	unique	unique	ADJ
can-1683	275	25	advantages	advantage	NOUN
can-1683	275	26	in	in	ADP
can-1683	275	27	the	the	DET
can-1683	275	28	diagnosis	diagnosis	NOUN
can-1683	275	29	and	and	CCONJ
can-1683	275	30	therapy	therapy	NOUN
can-1683	275	31	of	of	ADP
can-1683	275	32	cvds	cvds	PROPN
can-1683	275	33	.	.	PUNCT
can-1683	276	1	it	it	PRON
can-1683	276	2	can	can	AUX
can-1683	276	3	effectively	effectively	ADV
can-1683	276	4	solve	solve	VERB
can-1683	276	5	the	the	DET
can-1683	276	6	problems	problem	NOUN
can-1683	276	7	of	of	ADP
can-1683	276	8	targeting	target	VERB
can-1683	276	9	,	,	PUNCT
can-1683	276	10	local	local	ADJ
can-1683	276	11	drug	drug	NOUN
can-1683	276	12	delivery	delivery	NOUN
can-1683	276	13	,	,	PUNCT
can-1683	276	14	controlled	control	VERB
can-1683	276	15	release	release	NOUN
can-1683	276	16	,	,	PUNCT
can-1683	276	17	sustained	sustained	ADJ
can-1683	276	18	release	release	NOUN
can-1683	276	19	,	,	PUNCT
can-1683	276	20	and	and	CCONJ
can-1683	276	21	reducing	reduce	VERB
can-1683	276	22	toxicity	toxicity	NOUN
can-1683	276	23	while	while	SCONJ
can-1683	276	24	it	it	PRON
can-1683	276	25	is	be	AUX
can-1683	276	26	developing	develop	VERB
can-1683	276	27	toward	toward	ADP
can-1683	276	28	the	the	DET
can-1683	276	29	multifunctional	multifunctional	ADJ
can-1683	276	30	and	and	CCONJ
can-1683	276	31	integrated	integrated	ADJ
can-1683	276	32	direction	direction	NOUN
can-1683	276	33	of	of	ADP
can-1683	276	34	diagnosis	diagnosis	NOUN
can-1683	276	35	and	and	CCONJ
can-1683	276	36	therapy	therapy	NOUN
can-1683	276	37	.	.	PUNCT
can-1683	277	1	with	with	ADP
can-1683	277	2	the	the	DET
can-1683	277	3	innovation	innovation	NOUN
can-1683	277	4	of	of	ADP
can-1683	277	5	nanotechnology	nanotechnology	NOUN
can-1683	277	6	and	and	CCONJ
can-1683	277	7	the	the	DET
can-1683	277	8	deepening	deepen	VERB
can-1683	277	9	studies	study	NOUN
can-1683	277	10	on	on	ADP
can-1683	277	11	molecular	molecular	ADJ
can-1683	277	12	pathological	pathological	ADJ
can-1683	277	13	mechanism	mechanism	NOUN
can-1683	277	14	of	of	ADP
can-1683	277	15	cvds	cvds	PROPN
can-1683	277	16	,	,	PUNCT
can-1683	277	17	the	the	DET
can-1683	277	18	application	application	NOUN
can-1683	277	19	of	of	ADP
can-1683	277	20	nddss	nddss	NOUN
can-1683	277	21	will	will	AUX
can-1683	277	22	be	be	AUX
can-1683	277	23	promoted	promote	VERB
can-1683	277	24	,	,	PUNCT
can-1683	277	25	and	and	CCONJ
can-1683	277	26	new	new	ADJ
can-1683	277	27	techniques	technique	NOUN
can-1683	277	28	and	and	CCONJ
can-1683	277	29	methods	method	NOUN
can-1683	277	30	will	will	AUX
can-1683	277	31	be	be	AUX
can-1683	277	32	provided	provide	VERB
can-1683	277	33	for	for	ADP
can-1683	277	34	clinical	clinical	ADJ
can-1683	277	35	diagnosis	diagnosis	NOUN
can-1683	277	36	and	and	CCONJ
can-1683	277	37	therapy	therapy	NOUN
can-1683	277	38	.	.	PUNCT
can-1683	278	1	in	in	ADP
can-1683	278	2	addition	addition	NOUN
can-1683	278	3	,	,	PUNCT
can-1683	278	4	since	since	SCONJ
can-1683	278	5	the	the	DET
can-1683	278	6	study	study	NOUN
can-1683	278	7	on	on	ADP
can-1683	278	8	these	these	DET
can-1683	278	9	nano	nano	NOUN
can-1683	278	10	-	-	PUNCT
can-1683	278	11	carriers	carrier	NOUN
can-1683	278	12	is	be	AUX
can-1683	278	13	in	in	ADP
can-1683	278	14	its	its	PRON
can-1683	278	15	infancy	infancy	NOUN
can-1683	278	16	,	,	PUNCT
can-1683	278	17	many	many	ADJ
can-1683	278	18	problems	problem	NOUN
can-1683	278	19	still	still	ADV
can-1683	278	20	remain	remain	VERB
can-1683	278	21	unclear	unclear	ADJ
can-1683	278	22	.	.	PUNCT
can-1683	279	1	the	the	DET
can-1683	279	2	main	main	ADJ
can-1683	279	3	challenge	challenge	NOUN
can-1683	279	4	is	be	AUX
can-1683	279	5	how	how	SCONJ
can-1683	279	6	to	to	PART
can-1683	279	7	solve	solve	VERB
can-1683	279	8	the	the	DET
can-1683	279	9	biocompatibility	biocompatibility	NOUN
can-1683	279	10	of	of	ADP
can-1683	279	11	nano	nano	NOUN
can-1683	279	12	-	-	PUNCT
can-1683	279	13	drug	drug	NOUN
can-1683	279	14	-	-	PUNCT
can-1683	279	15	loaded	load	VERB
can-1683	279	16	particles	particle	NOUN
can-1683	279	17	themselves	themselves	PRON
can-1683	279	18	or	or	CCONJ
can-1683	279	19	their	their	PRON
can-1683	279	20	degradation	degradation	NOUN
can-1683	279	21	products	product	NOUN
can-1683	279	22	,	,	PUNCT
can-1683	279	23	which	which	PRON
can-1683	279	24	is	be	AUX
can-1683	279	25	need	need	ADJ
can-1683	279	26	to	to	PART
can-1683	279	27	be	be	AUX
can-1683	279	28	solved	solve	VERB
can-1683	279	29	in	in	ADP
can-1683	279	30	the	the	DET
can-1683	279	31	field	field	NOUN
can-1683	279	32	of	of	ADP
can-1683	279	33	nano	nano	NOUN
can-1683	279	34	-	-	PUNCT
can-1683	279	35	biomedicine	biomedicine	NOUN
can-1683	279	36	in	in	ADP
can-1683	279	37	the	the	DET
can-1683	279	38	future	future	NOUN
can-1683	279	39	.	.	PUNCT
can-1683	280	1	conflict	conflict	NOUN
can-1683	280	2	of	of	ADP
can-1683	280	3	interest	interest	NOUN
can-1683	280	4	the	the	DET
can-1683	280	5	authors	author	NOUN
can-1683	280	6	declared	declare	VERB
can-1683	280	7	no	no	DET
can-1683	280	8	conflict	conflict	NOUN
can-1683	280	9	of	of	ADP
can-1683	280	10	interest	interest	NOUN
can-1683	280	11	.	.	PUNCT
can-1683	281	1	references	reference	NOUN
can-1683	281	2	1	1	NUM
can-1683	281	3	.	.	PUNCT
can-1683	282	1	gaurav	gaurav	PROPN
can-1683	282	2	c	c	PROPN
can-1683	282	3	,	,	PUNCT
can-1683	282	4	saurav	saurav	PROPN
can-1683	282	5	b	b	NOUN
can-1683	282	6	,	,	PUNCT
can-1683	282	7	goutam	goutam	VERB
can-1683	282	8	r	r	NOUN
can-1683	282	9	,	,	PUNCT
can-1683	282	10	et	et	PROPN
can-1683	282	11	al	al	PROPN
can-1683	282	12	.	.	PUNCT
can-1683	283	1	nano	nano	NOUN
can-1683	283	2	-	-	PUNCT
can-1683	283	3	systems	system	NOUN
can-1683	283	4	for	for	ADP
can-1683	283	5	advanced	advanced	ADJ
can-1683	283	6	therapeutics	therapeutic	NOUN
can-1683	283	7	and	and	CCONJ
can-1683	283	8	diagnosis	diagnosis	NOUN
can-1683	283	9	of	of	ADP
can-1683	283	10	atherosclerosis	atherosclerosis	NOUN
can-1683	283	11	.	.	PUNCT
can-1683	284	1	current	current	ADJ
can-1683	284	2	pharmaceutical	pharmaceutical	ADJ
can-1683	284	3	design	design	NOUN
can-1683	284	4	2015	2015	NUM
can-1683	284	5	;	;	PUNCT
can-1683	284	6	21(30	21(30	NOUN
can-1683	284	7	):	):	PUNCT
can-1683	284	8	4498–4508	4498–4508	NUM
can-1683	284	9	.	.	PUNCT
can-1683	285	1	doi	doi	NOUN
can-1683	285	2	:	:	PUNCT
can-1683	285	3	10.2174/1381612821666150917094215	10.2174/1381612821666150917094215	NUM
can-1683	285	4	.	.	NOUN
can-1683	285	5	2	2	NUM
can-1683	285	6	.	.	X
can-1683	285	7	quan	quan	PROPN
can-1683	286	1	x	x	PROPN
can-1683	286	2	,	,	PUNCT
can-1683	286	3	rang	ring	VERB
can-1683	286	4	l	l	NOUN
can-1683	286	5	,	,	PUNCT
can-1683	286	6	yin	yin	PROPN
can-1683	286	7	x	x	X
can-1683	286	8	,	,	PUNCT
can-1683	286	9	et	et	PROPN
can-1683	286	10	al	al	PROPN
can-1683	286	11	.	.	PUNCT
can-1683	287	1	synthesis	synthesis	NOUN
can-1683	287	2	of	of	ADP
can-1683	287	3	pegylated	pegylate	VERB
can-1683	287	4	hyaluronic	hyaluronic	ADJ
can-1683	287	5	acid	acid	NOUN
can-1683	287	6	for	for	ADP
can-1683	287	7	loading	loading	NOUN
can-1683	287	8	dichloro(1,2	dichloro(1,2	NOUN
can-1683	287	9	-	-	PUNCT
can-1683	287	10	diaminocyclohexane)platinum(ii	diaminocyclohexane)platinum(ii	NOUN
can-1683	287	11	)	)	PUNCT
can-1683	287	12	(	(	PUNCT
can-1683	287	13	dachpt	dachpt	PROPN
can-1683	287	14	)	)	PUNCT
can-1683	287	15	in	in	ADP
can-1683	287	16	nanoparticles	nanoparticle	NOUN
can-1683	287	17	for	for	ADP
can-1683	287	18	cancer	cancer	NOUN
can-1683	287	19	treatment	treatment	NOUN
can-1683	287	20	.	.	PUNCT
can-1683	288	1	chinese	chinese	ADJ
can-1683	288	2	chemical	chemical	PROPN
can-1683	288	3	letters	letter	NOUN
can-1683	288	4	2015	2015	NUM
can-1683	288	5	;	;	PUNCT
can-1683	288	6	26(6	26(6	NUM
can-1683	288	7	):	):	PUNCT
can-1683	289	1	695–699	695–699	NUM
can-1683	289	2	.	.	PUNCT
can-1683	290	1	doi	doi	NOUN
can-1683	290	2	:	:	PUNCT
can-1683	290	3	10.1016	10.1016	NUM
can-1683	290	4	/	/	SYM
can-1683	290	5	j.cclet.2015.04.024	j.cclet.2015.04.024	PROPN
can-1683	290	6	.	.	NOUN
can-1683	291	1	3	3	X
can-1683	291	2	.	.	X
can-1683	291	3	landesman	landesman	ADJ
can-1683	291	4	-	-	PUNCT
can-1683	291	5	milo	milo	PROPN
can-1683	291	6	d	d	PROPN
can-1683	291	7	,	,	PUNCT
can-1683	291	8	goldsmith	goldsmith	PROPN
can-1683	291	9	m	m	PROPN
can-1683	291	10	,	,	PUNCT
can-1683	291	11	leviatan	leviatan	ADJ
can-1683	291	12	bs	bs	NOUN
can-1683	291	13	,	,	PUNCT
can-1683	292	1	et	et	PROPN
can-1683	292	2	al	al	PROPN
can-1683	292	3	.	.	PROPN
can-1683	292	4	hyaluronan	hyaluronan	PROPN
can-1683	292	5	grafted	graft	VERB
can-1683	292	6	lipid	lipid	NOUN
can-1683	292	7	-	-	PUNCT
can-1683	292	8	based	base	VERB
can-1683	292	9	nanoparticles	nanoparticle	NOUN
can-1683	292	10	as	as	ADP
can-1683	292	11	rnai	rnai	NOUN
can-1683	292	12	carriers	carrier	NOUN
can-1683	292	13	for	for	ADP
can-1683	292	14	cancer	cancer	NOUN
can-1683	292	15	cells	cell	NOUN
can-1683	292	16	.	.	PUNCT
can-1683	293	1	cancer	cancer	NOUN
can-1683	293	2	letters	letter	NOUN
can-1683	293	3	2013	2013	NUM
can-1683	293	4	;	;	PUNCT
can-1683	293	5	334(2	334(2	NUM
can-1683	293	6	):	):	PUNCT
can-1683	294	1	221–227	221–227	NUM
can-1683	294	2	.	.	PUNCT
can-1683	294	3	doi	doi	NOUN
can-1683	294	4	:	:	PUNCT
can-1683	294	5	10.1016	10.1016	NUM
can-1683	294	6	/	/	SYM
can-1683	294	7	j.canlet.2012.08.024	j.canlet.2012.08.024	NOUN
can-1683	294	8	.	.	PROPN
can-1683	294	9	4	4	NUM
can-1683	294	10	.	.	X
can-1683	294	11	chandrasekaran	chandrasekaran	PROPN
can-1683	294	12	s	s	PROPN
can-1683	294	13	,	,	PUNCT
can-1683	294	14	king	king	PROPN
can-1683	294	15	mr	mr	PROPN
can-1683	294	16	.	.	PROPN
can-1683	294	17	microenvironment	microenvironment	PROPN
can-1683	294	18	of	of	ADP
can-1683	294	19	tumor	tumor	NOUN
can-1683	294	20	-	-	PUNCT
can-1683	294	21	draining	drain	VERB
can-1683	294	22	lymph	lymph	NOUN
can-1683	294	23	nodes	node	NOUN
can-1683	294	24	:	:	PUNCT
can-1683	294	25	opportunities	opportunity	NOUN
can-1683	294	26	for	for	ADP
can-1683	294	27	liposome	liposome	NOUN
can-1683	294	28	-	-	PUNCT
can-1683	294	29	based	base	VERB
can-1683	294	30	targeted	target	VERB
can-1683	294	31	therapy	therapy	NOUN
can-1683	294	32	.	.	PUNCT
can-1683	295	1	international	international	ADJ
can-1683	295	2	journal	journal	NOUN
can-1683	295	3	of	of	ADP
can-1683	295	4	molecular	molecular	ADJ
can-1683	295	5	sciences	science	NOUN
can-1683	295	6	2014	2014	NUM
can-1683	295	7	;	;	PUNCT
can-1683	295	8	15(11	15(11	NUM
can-1683	295	9	):	):	PUNCT
can-1683	295	10	20209–20239	20209–20239	NUM
can-1683	295	11	.	.	PUNCT
can-1683	295	12	doi	doi	NOUN
can-1683	295	13	:	:	PUNCT
can-1683	295	14	10.3390	10.3390	NUM
can-1683	295	15	/	/	SYM
can-1683	295	16	ijms151120209	ijms151120209	NOUN
can-1683	295	17	.	.	PUNCT
can-1683	296	1	5	5	NUM
can-1683	296	2	.	.	PUNCT
can-1683	296	3	fan	fan	PROPN
can-1683	296	4	y	y	PROPN
can-1683	296	5	,	,	PUNCT
can-1683	296	6	chen	chen	PROPN
can-1683	296	7	c	c	PROPN
can-1683	296	8	,	,	PUNCT
can-1683	296	9	huang	huang	PROPN
can-1683	296	10	y	y	PROPN
can-1683	296	11	,	,	PUNCT
can-1683	297	1	et	et	PROPN
can-1683	297	2	al	al	PROPN
can-1683	297	3	.	.	PROPN
can-1683	297	4	study	study	NOUN
can-1683	297	5	of	of	ADP
can-1683	297	6	the	the	DET
can-1683	297	7	ph	ph	ADJ
can-1683	297	8	-	-	ADJ
can-1683	297	9	sensitive	sensitive	ADJ
can-1683	297	10	mechanism	mechanism	NOUN
can-1683	297	11	of	of	ADP
can-1683	297	12	tumor	tumor	NOUN
can-1683	297	13	-	-	PUNCT
can-1683	297	14	targeting	target	VERB
can-1683	297	15	liposomes	liposome	NOUN
can-1683	297	16	.	.	PUNCT
can-1683	298	1	colloids	colloid	NOUN
can-1683	298	2	and	and	CCONJ
can-1683	298	3	surfaces	surface	NOUN
can-1683	298	4	b	b	NUM
can-1683	298	5	:	:	PUNCT
can-1683	298	6	biointerfaces	biointerface	NOUN
can-1683	298	7	2017	2017	NUM
can-1683	298	8	;	;	PUNCT
can-1683	298	9	151	151	NUM
can-1683	298	10	:	:	PUNCT
can-1683	298	11	19–25	19–25	NUM
can-1683	298	12	.	.	PUNCT
can-1683	299	1	doi	doi	NOUN
can-1683	299	2	:	:	PUNCT
can-1683	299	3	10.1016	10.1016	NUM
can-1683	299	4	/	/	SYM
can-1683	299	5	j.colsurfb.2016.11.042	j.colsurfb.2016.11.042	NOUN
can-1683	299	6	.	.	PROPN
can-1683	300	1	6	6	NUM
can-1683	300	2	.	.	PUNCT
can-1683	301	1	li	li	PROPN
can-1683	301	2	z	z	PROPN
can-1683	301	3	,	,	PUNCT
can-1683	301	4	ding	ding	PROPN
can-1683	301	5	j	j	PROPN
can-1683	301	6	,	,	PUNCT
can-1683	301	7	xiao	xiao	PROPN
can-1683	301	8	c	c	PROPN
can-1683	301	9	,	,	PUNCT
can-1683	301	10	et	et	PROPN
can-1683	301	11	al	al	PROPN
can-1683	301	12	.	.	PUNCT
can-1683	301	13	glucose	glucose	NOUN
can-1683	301	14	-	-	PUNCT
can-1683	301	15	sensitive	sensitive	ADJ
can-1683	301	16	polypeptide	polypeptide	ADJ
can-1683	301	17	micelles	micelle	NOUN
can-1683	301	18	for	for	ADP
can-1683	301	19	self	self	NOUN
can-1683	301	20	-	-	PUNCT
can-1683	301	21	regulated	regulate	VERB
can-1683	301	22	insulin	insulin	NOUN
can-1683	301	23	release	release	NOUN
can-1683	301	24	at	at	ADP
can-1683	301	25	physiological	physiological	ADJ
can-1683	301	26	ph	ph	PROPN
can-1683	301	27	.	.	PROPN
can-1683	301	28	journal	journal	PROPN
can-1683	301	29	of	of	ADP
can-1683	301	30	materials	material	NOUN
can-1683	301	31	chemistry	chemistry	NOUN
can-1683	301	32	2012	2012	NUM
can-1683	301	33	;	;	PUNCT
can-1683	301	34	22(24	22(24	NUM
can-1683	301	35	):	):	PUNCT
can-1683	301	36	12319–12328	12319–12328	NUM
can-1683	301	37	.	.	PUNCT
can-1683	302	1	doi	doi	NOUN
can-1683	302	2	:	:	PUNCT
can-1683	302	3	10.1039	10.1039	NUM
can-1683	302	4	/	/	SYM
can-1683	302	5	c2jm31040f	c2jm31040f	PROPN
can-1683	302	6	.	.	PUNCT
can-1683	303	1	7	7	X
can-1683	303	2	.	.	X
can-1683	303	3	afsharzadeh	afsharzadeh	PROPN
can-1683	303	4	m	m	PROPN
can-1683	303	5	,	,	PUNCT
can-1683	303	6	hashemi	hashemi	PROPN
can-1683	303	7	m	m	PROPN
can-1683	303	8	,	,	PUNCT
can-1683	303	9	mokhtarzadeh	mokhtarzadeh	NOUN
can-1683	303	10	a	a	X
can-1683	303	11	,	,	PUNCT
can-1683	303	12	et	et	PROPN
can-1683	303	13	al	al	PROPN
can-1683	303	14	.	.	PUNCT
can-1683	304	1	recent	recent	ADJ
can-1683	304	2	advances	advance	NOUN
can-1683	304	3	in	in	ADP
can-1683	304	4	co	co	ADJ
can-1683	304	5	-	-	NOUN
can-1683	304	6	delivery	delivery	NOUN
can-1683	304	7	systems	system	NOUN
can-1683	304	8	based	base	VERB
can-1683	304	9	on	on	ADP
can-1683	304	10	polymeric	polymeric	ADJ
can-1683	304	11	nanoparticle	nanoparticle	NOUN
can-1683	304	12	for	for	ADP
can-1683	304	13	cancer	cancer	NOUN
can-1683	304	14	treatment	treatment	NOUN
can-1683	304	15	.	.	PUNCT
can-1683	305	1	artificial	artificial	ADJ
can-1683	305	2	cells	cell	NOUN
can-1683	305	3	,	,	PUNCT
can-1683	305	4	nanomedicine	nanomedicine	NOUN
can-1683	305	5	,	,	PUNCT
can-1683	305	6	and	and	CCONJ
can-1683	305	7	biotechnology	biotechnology	NOUN
can-1683	305	8	2018	2018	NUM
can-1683	305	9	;	;	PUNCT
can-1683	305	10	46(6	46(6	ADV
can-1683	305	11	):	):	PUNCT
can-1683	306	1	1095–1110	1095–1110	NUM
can-1683	306	2	.	.	PUNCT
can-1683	306	3	doi	doi	NOUN
can-1683	306	4	:	:	PUNCT
can-1683	306	5	10.1080/21691401.2017.1376675	10.1080/21691401.2017.1376675	NUM
can-1683	306	6	.	.	NOUN
can-1683	306	7	8	8	NUM
can-1683	306	8	.	.	PUNCT
can-1683	307	1	wang	wang	PROPN
can-1683	307	2	w	w	PROPN
can-1683	307	3	,	,	PUNCT
can-1683	307	4	ding	ding	PROPN
can-1683	307	5	j	j	PROPN
can-1683	307	6	,	,	PUNCT
can-1683	307	7	xiao	xiao	PROPN
can-1683	307	8	c	c	PROPN
can-1683	307	9	,	,	PUNCT
can-1683	307	10	et	et	PROPN
can-1683	307	11	al	al	PROPN
can-1683	307	12	.	.	PUNCT
can-1683	307	13	synthesis	synthesis	NOUN
can-1683	307	14	of	of	ADP
can-1683	307	15	amphiphilic	amphiphilic	ADJ
can-1683	307	16	alternating	alternate	VERB
can-1683	307	17	polyesters	polyester	NOUN
can-1683	307	18	with	with	ADP
can-1683	307	19	oligo(ethylene	oligo(ethylene	ADJ
can-1683	307	20	glycol	glycol	NOUN
can-1683	307	21	)	)	PUNCT
can-1683	307	22	side	side	NOUN
can-1683	307	23	chains	chain	NOUN
can-1683	307	24	and	and	CCONJ
can-1683	307	25	potential	potential	ADJ
can-1683	307	26	use	use	NOUN
can-1683	307	27	for	for	ADP
can-1683	307	28	sustained	sustained	ADJ
can-1683	307	29	release	release	NOUN
can-1683	307	30	drug	drug	NOUN
can-1683	307	31	delivery	delivery	NOUN
can-1683	307	32	.	.	PUNCT
can-1683	308	1	biomacromolecules	biomacromolecule	NOUN
can-1683	308	2	2011	2011	NUM
can-1683	308	3	;	;	PUNCT
can-1683	308	4	12(7	12(7	NUM
can-1683	308	5	):	):	PUNCT
can-1683	308	6	2466–2474	2466–2474	NUM
can-1683	308	7	.	.	PUNCT
can-1683	309	1	doi	doi	NOUN
can-1683	309	2	:	:	PUNCT
can-1683	309	3	10.1021	10.1021	NUM
can-1683	309	4	/	/	SYM
can-1683	309	5	bm200668n	bm200668n	PROPN
can-1683	309	6	.	.	PROPN
can-1683	310	1	9	9	NUM
can-1683	310	2	.	.	X
can-1683	310	3	ping	ping	PROPN
can-1683	310	4	s	s	PROPN
can-1683	310	5	,	,	PUNCT
can-1683	310	6	wei	wei	PROPN
can-1683	310	7	h	h	PROPN
can-1683	310	8	,	,	PUNCT
can-1683	310	9	lin	lin	PROPN
can-1683	310	10	k	k	PROPN
can-1683	310	11	,	,	PUNCT
can-1683	310	12	et	et	PROPN
can-1683	310	13	al	al	PROPN
can-1683	310	14	.	.	PUNCT
can-1683	311	1	sirna	sirna	PROPN
can-1683	311	2	-	-	PUNCT
can-1683	311	3	loaded	load	VERB
can-1683	311	4	poly(histidine	poly(histidine	NOUN
can-1683	311	5	-	-	PUNCT
can-1683	311	6	arginine)6	arginine)6	NOUN
can-1683	311	7	-	-	ADJ
can-1683	311	8	modified	modify	VERB
can-1683	311	9	chitosan	chitosan	NOUN
can-1683	311	10	nanoparticle	nanoparticle	NOUN
can-1683	311	11	with	with	ADP
can-1683	311	12	enhanced	enhanced	ADJ
can-1683	311	13	cell	cell	NOUN
can-1683	311	14	-	-	PUNCT
can-1683	311	15	penetrating	penetrate	VERB
can-1683	311	16	and	and	CCONJ
can-1683	311	17	endosomal	endosomal	ADJ
can-1683	311	18	escape	escape	NOUN
can-1683	311	19	capacities	capacity	NOUN
can-1683	311	20	for	for	ADP
can-1683	311	21	suppressing	suppress	VERB
can-1683	311	22	breast	breast	NOUN
can-1683	311	23	tumor	tumor	NOUN
can-1683	311	24	metastasis	metastasis	NOUN
can-1683	311	25	.	.	PUNCT
can-1683	312	1	international	international	ADJ
can-1683	312	2	journal	journal	NOUN
can-1683	312	3	of	of	ADP
can-1683	312	4	nanomedicine	nanomedicine	PROPN
can-1683	312	5	2017	2017	NUM
can-1683	312	6	;	;	PUNCT
can-1683	312	7	12	12	NUM
can-1683	312	8	:	:	SYM
can-1683	312	9	3221–3234	3221–3234	NUM
can-1683	312	10	.	.	PUNCT
can-1683	312	11	doi	doi	NOUN
can-1683	312	12	:	:	PUNCT
can-1683	312	13	10.2147	10.2147	NUM
can-1683	312	14	/	/	SYM
can-1683	312	15	ijn.s129436	ijn.s129436	NOUN
can-1683	312	16	.	.	PUNCT
can-1683	313	1	10	10	NUM
can-1683	313	2	.	.	PUNCT
can-1683	314	1	kesharwani	kesharwani	PROPN
can-1683	314	2	p	p	PROPN
can-1683	314	3	,	,	PUNCT
can-1683	314	4	gajbhiye	gajbhiye	ADJ
can-1683	314	5	v	v	NOUN
can-1683	314	6	,	,	PUNCT
can-1683	314	7	jain	jain	PROPN
can-1683	314	8	nk	nk	PROPN
can-1683	314	9	.	.	PUNCT
can-1683	315	1	a	a	DET
can-1683	315	2	review	review	NOUN
can-1683	315	3	of	of	ADP
can-1683	315	4	nanocarriers	nanocarrier	NOUN
can-1683	315	5	for	for	ADP
can-1683	315	6	the	the	DET
can-1683	315	7	delivery	delivery	NOUN
can-1683	315	8	of	of	ADP
can-1683	315	9	small	small	ADJ
can-1683	315	10	interfering	interfere	VERB
can-1683	315	11	rna	rna	NOUN
can-1683	315	12	.	.	PUNCT
can-1683	316	1	biomaterials	biomaterial	NOUN
can-1683	316	2	2012	2012	NUM
can-1683	316	3	;	;	PUNCT
can-1683	316	4	33(29	33(29	NUM
can-1683	316	5	):	):	PUNCT
can-1683	316	6	7138–7150	7138–7150	NUM
can-1683	316	7	.	.	PUNCT
can-1683	317	1	doi	doi	NOUN
can-1683	317	2	:	:	PUNCT
can-1683	317	3	10.1016	10.1016	NUM
can-1683	317	4	/	/	SYM
can-1683	317	5	j.biomaterials.2012.06.068	j.biomaterials.2012.06.068	PROPN
can-1683	317	6	.	.	PUNCT
can-1683	318	1	11	11	NUM
can-1683	318	2	.	.	PUNCT
can-1683	319	1	baeza	baeza	PROPN
can-1683	319	2	a	a	PROPN
can-1683	319	3	,	,	PUNCT
can-1683	319	4	ruiz	ruiz	NOUN
can-1683	319	5	-	-	PUNCT
can-1683	319	6	molina	molina	PROPN
can-1683	319	7	d	d	PROPN
can-1683	319	8	,	,	PUNCT
can-1683	319	9	vallet	vallet	PROPN
can-1683	319	10	-	-	PUNCT
can-1683	319	11	regi	regi	PROPN
can-1683	319	12	m.	m.	PROPN
can-1683	319	13	recent	recent	ADJ
can-1683	319	14	advances	advance	NOUN
can-1683	319	15	in	in	ADP
can-1683	319	16	porous	porous	ADJ
can-1683	319	17	nanoparticles	nanoparticle	NOUN
can-1683	319	18	for	for	ADP
can-1683	319	19	drug	drug	NOUN
can-1683	319	20	delivery	delivery	NOUN
can-1683	319	21	in	in	ADP
can-1683	319	22	antitumoral	antitumoral	ADJ
can-1683	319	23	applications	application	NOUN
can-1683	319	24	:	:	PUNCT
can-1683	319	25	inorganic	inorganic	ADJ
can-1683	319	26	nanoparticles	nanoparticle	NOUN
can-1683	319	27	and	and	CCONJ
can-1683	319	28	nanoscale	nanoscale	NOUN
can-1683	319	29	metal	metal	NOUN
can-1683	319	30	-	-	PUNCT
can-1683	319	31	organic	organic	ADJ
can-1683	319	32	frameworks	framework	NOUN
can-1683	319	33	.	.	PUNCT
can-1683	320	1	expert	expert	ADJ
can-1683	320	2	opinion	opinion	NOUN
can-1683	320	3	on	on	ADP
can-1683	320	4	drug	drug	NOUN
can-1683	320	5	delivery	delivery	NOUN
can-1683	320	6	2017	2017	NUM
can-1683	320	7	;	;	PUNCT
can-1683	320	8	14(6	14(6	NUM
can-1683	320	9	):	):	PUNCT
can-1683	321	1	783–796	783–796	NUM
can-1683	321	2	.	.	PUNCT
can-1683	321	3	doi	doi	NOUN
can-1683	321	4	:	:	PUNCT
can-1683	321	5	10.1080/17425247.2016.1229298	10.1080/17425247.2016.1229298	NUM
can-1683	321	6	12	12	NUM
can-1683	321	7	.	.	PUNCT
can-1683	322	1	liang	liang	PROPN
can-1683	322	2	jj	jj	PROPN
can-1683	322	3	,	,	PUNCT
can-1683	322	4	zhou	zhou	PROPN
can-1683	322	5	yy	yy	PROPN
can-1683	322	6	,	,	PUNCT
can-1683	322	7	wu	wu	PROPN
can-1683	322	8	j	j	PROPN
can-1683	322	9	,	,	PUNCT
can-1683	322	10	et	et	PROPN
can-1683	322	11	al	al	PROPN
can-1683	322	12	.	.	PUNCT
can-1683	322	13	gold	gold	NOUN
can-1683	322	14	nanoparticle	nanoparticle	NOUN
can-1683	322	15	-	-	PUNCT
can-1683	322	16	based	base	VERB
can-1683	322	17	drug	drug	NOUN
can-1683	322	18	delivery	delivery	NOUN
can-1683	322	19	platform	platform	NOUN
can-1683	322	20	for	for	ADP
can-1683	322	21	antineoplastic	antineoplastic	ADJ
can-1683	322	22	chemotherapy	chemotherapy	NOUN
can-1683	322	23	.	.	PUNCT
can-1683	323	1	current	current	ADJ
can-1683	323	2	drug	drug	NOUN
can-1683	323	3	metabolism	metabolism	NOUN
can-1683	323	4	2014	2014	NUM
can-1683	323	5	;	;	PUNCT
can-1683	323	6	15(6	15(6	NUM
can-1683	323	7	):	):	PUNCT
can-1683	324	1	620–631	620–631	NUM
can-1683	324	2	.	.	PUNCT
can-1683	325	1	doi	doi	NOUN
can-1683	325	2	:	:	PUNCT
can-1683	325	3	10.2174/1389200215666140605131427	10.2174/1389200215666140605131427	NUM
can-1683	325	4	.	.	NOUN
can-1683	325	5	13	13	NUM
can-1683	325	6	.	.	X
can-1683	326	1	khafaji	khafaji	PROPN
can-1683	326	2	m	m	PROPN
can-1683	326	3	,	,	PUNCT
can-1683	326	4	zamani	zamani	PROPN
can-1683	326	5	m	m	PROPN
can-1683	326	6	,	,	PUNCT
can-1683	326	7	golizadeh	golizadeh	NOUN
can-1683	326	8	m	m	PROPN
can-1683	326	9	,	,	PUNCT
can-1683	326	10	et	et	PROPN
can-1683	326	11	al	al	PROPN
can-1683	326	12	.	.	PROPN
can-1683	326	13	inorganic	inorganic	ADJ
can-1683	326	14	nanomaterials	nanomaterial	NOUN
can-1683	326	15	for	for	ADP
can-1683	326	16	chemo	chemo	NOUN
can-1683	326	17	/	/	SYM
can-1683	326	18	photothermal	photothermal	ADJ
can-1683	326	19	therapy	therapy	NOUN
can-1683	326	20	:	:	PUNCT
can-1683	326	21	a	a	DET
can-1683	326	22	promising	promising	ADJ
can-1683	326	23	horizon	horizon	NOUN
can-1683	326	24	on	on	ADP
can-1683	326	25	effective	effective	ADJ
can-1683	326	26	cancer	cancer	NOUN
can-1683	326	27	treatment	treatment	NOUN
can-1683	326	28	.	.	PUNCT
can-1683	327	1	biophysical	biophysical	ADJ
can-1683	327	2	reviews	review	NOUN
can-1683	327	3	2019	2019	NUM
can-1683	327	4	;	;	PUNCT
can-1683	327	5	11(3	11(3	NUM
can-1683	327	6	):	):	PUNCT
can-1683	328	1	335–352	335–352	NUM
can-1683	328	2	.	.	PUNCT
can-1683	329	1	doi	doi	NOUN
can-1683	329	2	:	:	PUNCT
can-1683	329	3	10.1007	10.1007	NUM
can-1683	329	4	/	/	SYM
can-1683	329	5	s12551	s12551	NOUN
can-1683	329	6	-	-	PUNCT
can-1683	329	7	019	019	NUM
can-1683	329	8	-	-	PUNCT
can-1683	329	9	00532	00532	NUM
can-1683	329	10	-	-	SYM
can-1683	329	11	3	3	NUM
can-1683	329	12	14	14	NUM
can-1683	329	13	.	.	PUNCT
can-1683	330	1	perioli	perioli	PROPN
can-1683	330	2	l	l	NOUN
can-1683	330	3	,	,	PUNCT
can-1683	330	4	pagano	pagano	PROPN
can-1683	330	5	c	c	PROPN
can-1683	330	6	,	,	PUNCT
can-1683	330	7	ceccarini	ceccarini	PROPN
can-1683	330	8	mr	mr	PROPN
can-1683	330	9	.	.	PROPN
can-1683	330	10	current	current	ADJ
can-1683	330	11	highlights	highlight	NOUN
can-1683	330	12	about	about	ADP
can-1683	330	13	the	the	DET
can-1683	330	14	safety	safety	NOUN
can-1683	330	15	of	of	ADP
can-1683	330	16	inorganic	inorganic	ADJ
can-1683	330	17	nanomaterials	nanomaterial	NOUN
can-1683	330	18	in	in	ADP
can-1683	330	19	healthcare	healthcare	PROPN
can-1683	330	20	.	.	PUNCT
can-1683	331	1	current	current	ADJ
can-1683	331	2	medicinal	medicinal	ADJ
can-1683	331	3	chemistry	chemistry	NOUN
can-1683	331	4	2019	2019	NUM
can-1683	331	5	;	;	PUNCT
can-1683	331	6	26(12	26(12	NUM
can-1683	331	7	):	):	PUNCT
can-1683	331	8	2147–2165	2147–2165	NUM
can-1683	331	9	.	.	PUNCT
can-1683	332	1	doi	doi	NOUN
can-1683	332	2	:	:	PUNCT
can-1683	332	3	10.2174/0929867325666180723121804	10.2174/0929867325666180723121804	NUM
can-1683	332	4	.	.	PUNCT
can-1683	333	1	15	15	NUM
can-1683	333	2	.	.	PUNCT
can-1683	334	1	zhang	zhang	PROPN
can-1683	334	2	z	z	PROPN
can-1683	334	3	,	,	PUNCT
can-1683	334	4	runa	runa	PROPN
can-1683	334	5	a	a	PROPN
can-1683	334	6	,	,	PUNCT
can-1683	334	7	wu	wu	PROPN
can-1683	334	8	j	j	PROPN
can-1683	334	9	,	,	PUNCT
can-1683	334	10	et	et	PROPN
can-1683	334	11	al	al	PROPN
can-1683	334	12	.	.	PROPN
can-1683	334	13	bioresponsive	bioresponsive	PROPN
can-1683	334	14	nanogated	nanogate	VERB
can-1683	334	15	ensemble	ensemble	ADJ
can-1683	334	16	based	base	VERB
can-1683	334	17	on	on	ADP
can-1683	334	18	structure	structure	NOUN
can-1683	334	19	-	-	PUNCT
can-1683	334	20	switchable	switchable	NOUN
can-1683	334	21	aptamer	aptamer	NOUN
can-1683	334	22	directed	direct	VERB
can-1683	334	23	assembly	assembly	NOUN
can-1683	334	24	and	and	CCONJ
can-1683	334	25	disassembly	disassembly	NOUN
can-1683	334	26	of	of	ADP
can-1683	334	27	gold	gold	ADJ
can-1683	334	28	nanoparticles	nanoparticle	NOUN
can-1683	334	29	from	from	ADP
can-1683	334	30	mesoporous	mesoporous	ADJ
can-1683	334	31	silica	silica	NOUN
can-1683	334	32	supports	support	NOUN
can-1683	334	33	.	.	PUNCT
can-1683	335	1	chinese	chinese	ADJ
can-1683	335	2	chemical	chemical	NOUN
can-1683	335	3	letters	letter	NOUN
can-1683	335	4	2019	2019	NUM
can-1683	335	5	;	;	PUNCT
can-1683	335	6	30(3	30(3	NUM
can-1683	335	7	):	):	PUNCT
can-1683	335	8	267–270	267–270	NUM
can-1683	335	9	.	.	PUNCT
can-1683	336	1	doi	doi	NOUN
can-1683	336	2	:	:	PUNCT
can-1683	336	3	10.1016	10.1016	NUM
can-1683	336	4	/	/	SYM
can-1683	336	5	j.cclet.2018.10.019	j.cclet.2018.10.019	PROPN
can-1683	336	6	.	.	PUNCT
can-1683	337	1	16	16	NUM
can-1683	337	2	.	.	PUNCT
can-1683	338	1	holback	holback	PROPN
can-1683	338	2	h	h	PROPN
can-1683	338	3	,	,	PUNCT
can-1683	338	4	yeo	yeo	PROPN
can-1683	338	5	y.	y.	PROPN
can-1683	338	6	intratumoral	intratumoral	PROPN
can-1683	338	7	drug	drug	NOUN
can-1683	338	8	delivery	delivery	NOUN
can-1683	338	9	with	with	ADP
can-1683	338	10	nanoparticulate	nanoparticulate	ADJ
can-1683	338	11	carriers	carrier	NOUN
can-1683	338	12	.	.	PUNCT
can-1683	339	1	pharmaceutical	pharmaceutical	ADJ
can-1683	339	2	research	research	NOUN
can-1683	339	3	2011	2011	NUM
can-1683	339	4	;	;	PUNCT
can-1683	339	5	28(8	28(8	NUM
can-1683	339	6	):	):	PUNCT
can-1683	339	7	1819–1830	1819–1830	NUM
can-1683	339	8	.	.	PUNCT
can-1683	340	1	21	21	NUM
can-1683	340	2	doi	doi	NOUN
can-1683	340	3	:	:	PUNCT
can-1683	340	4	10.1007	10.1007	NUM
can-1683	340	5	/	/	SYM
can-1683	340	6	s11095	s11095	NOUN
can-1683	340	7	-	-	PUNCT
can-1683	340	8	010	010	NUM
can-1683	340	9	-	-	PUNCT
can-1683	340	10	0360	0360	NUM
can-1683	340	11	-	-	PUNCT
can-1683	340	12	y.	y.	NOUN
can-1683	340	13	17	17	NUM
can-1683	340	14	.	.	PUNCT
can-1683	341	1	maeda	maeda	PROPN
can-1683	341	2	h	h	PROPN
can-1683	341	3	,	,	PUNCT
can-1683	341	4	nakamura	nakamura	PROPN
can-1683	341	5	h	h	PROPN
can-1683	341	6	,	,	PUNCT
can-1683	341	7	fang	fang	PROPN
can-1683	341	8	j.	j.	PROPN
can-1683	341	9	the	the	DET
can-1683	341	10	epr	epr	PROPN
can-1683	341	11	effect	effect	NOUN
can-1683	341	12	for	for	ADP
can-1683	341	13	macromolecular	macromolecular	ADJ
can-1683	341	14	drug	drug	NOUN
can-1683	341	15	delivery	delivery	NOUN
can-1683	341	16	to	to	ADP
can-1683	341	17	solid	solid	ADJ
can-1683	341	18	tumors	tumor	NOUN
can-1683	341	19	:	:	PUNCT
can-1683	341	20	improvement	improvement	NOUN
can-1683	341	21	of	of	ADP
can-1683	341	22	tumor	tumor	NOUN
can-1683	341	23	uptake	uptake	NOUN
can-1683	341	24	,	,	PUNCT
can-1683	341	25	lowering	lower	VERB
can-1683	341	26	of	of	ADP
can-1683	341	27	systemic	systemic	ADJ
can-1683	341	28	toxicity	toxicity	NOUN
can-1683	341	29	,	,	PUNCT
can-1683	341	30	and	and	CCONJ
can-1683	341	31	distinct	distinct	ADJ
can-1683	341	32	tumor	tumor	NOUN
can-1683	341	33	imaging	imaging	NOUN
can-1683	341	34	in	in	ADP
can-1683	341	35	vivo	vivo	NOUN
can-1683	341	36	.	.	PUNCT
can-1683	342	1	advanced	advanced	ADJ
can-1683	342	2	drug	drug	NOUN
can-1683	342	3	delivery	delivery	NOUN
can-1683	342	4	reviews	review	NOUN
can-1683	342	5	2013	2013	NUM
can-1683	342	6	;	;	PUNCT
can-1683	342	7	65(1	65(1	NOUN
can-1683	342	8	):	):	PUNCT
can-1683	342	9	71–79	71–79	ADV
can-1683	342	10	.	.	PUNCT
can-1683	343	1	doi	doi	NOUN
can-1683	343	2	:	:	PUNCT
can-1683	343	3	10.1016	10.1016	NUM
can-1683	343	4	/	/	SYM
can-1683	343	5	j.addr.2012.10.002	j.addr.2012.10.002	PROPN
can-1683	343	6	.	.	PROPN
can-1683	344	1	18	18	NUM
can-1683	344	2	.	.	PUNCT
can-1683	344	3	flogel	flogel	PROPN
can-1683	344	4	u	u	PROPN
can-1683	344	5	,	,	PUNCT
can-1683	344	6	ding	de	VERB
can-1683	344	7	z	z	PROPN
can-1683	344	8	,	,	PUNCT
can-1683	344	9	hardung	hardung	PROPN
can-1683	344	10	h	h	PROPN
can-1683	344	11	,	,	PUNCT
can-1683	344	12	et	et	PROPN
can-1683	344	13	al	al	PROPN
can-1683	344	14	.	.	PROPN
can-1683	345	1	in	in	ADP
can-1683	345	2	vivo	vivo	ADJ
can-1683	345	3	monitoring	monitoring	NOUN
can-1683	345	4	of	of	ADP
can-1683	345	5	inflammation	inflammation	NOUN
can-1683	345	6	after	after	ADP
can-1683	345	7	cardiac	cardiac	ADJ
can-1683	345	8	and	and	CCONJ
can-1683	345	9	cerebral	cerebral	ADJ
can-1683	345	10	ischemia	ischemia	NOUN
can-1683	345	11	by	by	ADP
can-1683	345	12	fluorine	fluorine	NOUN
can-1683	345	13	magnetic	magnetic	ADJ
can-1683	345	14	resonance	resonance	NOUN
can-1683	345	15	imaging	imaging	NOUN
can-1683	345	16	.	.	PUNCT
can-1683	346	1	circulation	circulation	NOUN
can-1683	346	2	2008	2008	NUM
can-1683	346	3	;	;	PUNCT
can-1683	346	4	118(2	118(2	NUM
can-1683	346	5	):	):	PUNCT
can-1683	346	6	140–148	140–148	NUM
can-1683	346	7	.	.	PUNCT
can-1683	347	1	doi	doi	NOUN
can-1683	347	2	:	:	PUNCT
can-1683	347	3	10.1161	10.1161	NUM
can-1683	347	4	/	/	SYM
can-1683	347	5	circulationaha.107.737890	circulationaha.107.737890	NOUN
can-1683	347	6	.	.	NOUN
can-1683	348	1	19	19	NUM
can-1683	348	2	.	.	PUNCT
can-1683	349	1	hemmati	hemmati	PROPN
can-1683	349	2	k	k	PROPN
can-1683	349	3	,	,	PUNCT
can-1683	349	4	ghaemy	ghaemy	NOUN
can-1683	349	5	m.	m.	NOUN
can-1683	349	6	synthesis	synthesis	NOUN
can-1683	349	7	of	of	ADP
can-1683	349	8	new	new	ADJ
can-1683	349	9	thermo	thermo	NOUN
can-1683	349	10	/	/	SYM
can-1683	349	11	ph	ph	ADJ
can-1683	349	12	sensitive	sensitive	ADJ
can-1683	349	13	drug	drug	NOUN
can-1683	349	14	delivery	delivery	NOUN
can-1683	349	15	systems	system	NOUN
can-1683	349	16	based	base	VERB
can-1683	349	17	on	on	ADP
can-1683	349	18	tragacanth	tragacanth	ADJ
can-1683	349	19	gum	gum	NOUN
can-1683	349	20	polysaccharide	polysaccharide	NOUN
can-1683	349	21	.	.	PUNCT
can-1683	350	1	international	international	ADJ
can-1683	350	2	journal	journal	NOUN
can-1683	350	3	of	of	ADP
can-1683	350	4	biological	biological	ADJ
can-1683	350	5	macromolecules	macromolecule	NOUN
can-1683	350	6	2016	2016	NUM
can-1683	350	7	;	;	PUNCT
can-1683	350	8	87	87	NUM
can-1683	350	9	:	:	SYM
can-1683	350	10	415	415	NUM
can-1683	350	11	–	–	PUNCT
can-1683	350	12	425	425	NUM
can-1683	350	13	.	.	PUNCT
can-1683	351	1	doi	doi	NOUN
can-1683	351	2	:	:	PUNCT
can-1683	351	3	10.1016	10.1016	NUM
can-1683	351	4	/	/	SYM
can-1683	351	5	j.ijbiomac.2016.03.005	j.ijbiomac.2016.03.005	PROPN
can-1683	351	6	.	.	PROPN
can-1683	352	1	20	20	NUM
can-1683	352	2	.	.	PUNCT
can-1683	353	1	korin	korin	PROPN
can-1683	353	2	n	n	PART
can-1683	353	3	,	,	PUNCT
can-1683	353	4	kanapathipillai	kanapathipillai	PROPN
can-1683	353	5	m	m	PROPN
can-1683	353	6	,	,	PUNCT
can-1683	353	7	matthews	matthews	PROPN
can-1683	353	8	bd	bd	PROPN
can-1683	353	9	,	,	PUNCT
can-1683	353	10	et	et	PROPN
can-1683	353	11	al	al	PROPN
can-1683	353	12	.	.	PROPN
can-1683	353	13	shear	shear	NOUN
can-1683	353	14	-	-	PUNCT
can-1683	353	15	activated	activate	VERB
can-1683	353	16	nanotherapeutics	nanotherapeutic	NOUN
can-1683	353	17	for	for	ADP
can-1683	353	18	drug	drug	NOUN
can-1683	353	19	targeting	target	VERB
can-1683	353	20	to	to	PART
can-1683	353	21	obstructed	obstruct	VERB
can-1683	353	22	blood	blood	NOUN
can-1683	353	23	vessels	vessel	NOUN
can-1683	353	24	.	.	PUNCT
can-1683	354	1	science	science	NOUN
can-1683	354	2	2012	2012	NUM
can-1683	354	3	;	;	PUNCT
can-1683	354	4	337(6095	337(6095	NUM
can-1683	354	5	):	):	PUNCT
can-1683	354	6	738–742	738–742	NUM
can-1683	354	7	.	.	PUNCT
can-1683	354	8	doi	doi	NOUN
can-1683	354	9	:	:	PUNCT
can-1683	354	10	10.1126	10.1126	NUM
can-1683	354	11	/	/	SYM
can-1683	354	12	science.1217815	science.1217815	NOUN
can-1683	354	13	.	.	NOUN
can-1683	354	14	21	21	NUM
can-1683	354	15	.	.	PUNCT
can-1683	355	1	tan	tan	PROPN
can-1683	355	2	j	j	PROPN
can-1683	355	3	,	,	PUNCT
can-1683	355	4	thomas	thomas	PROPN
can-1683	355	5	a	a	PROPN
can-1683	355	6	,	,	PUNCT
can-1683	355	7	liu	liu	PROPN
can-1683	355	8	y.	y.	PROPN
can-1683	355	9	influence	influence	PROPN
can-1683	355	10	of	of	ADP
can-1683	355	11	red	red	ADJ
can-1683	355	12	blood	blood	NOUN
can-1683	355	13	cells	cell	NOUN
can-1683	355	14	on	on	ADP
can-1683	355	15	nanoparticle	nanoparticle	NOUN
can-1683	355	16	targeted	target	VERB
can-1683	355	17	delivery	delivery	NOUN
can-1683	355	18	in	in	ADP
can-1683	355	19	microcirculation	microcirculation	NOUN
can-1683	355	20	.	.	PUNCT
can-1683	356	1	soft	soft	ADJ
can-1683	356	2	matter	matter	NOUN
can-1683	356	3	2011	2011	NUM
can-1683	356	4	;	;	PUNCT
can-1683	356	5	8	8	NUM
can-1683	356	6	:	:	SYM
can-1683	356	7	1934–1946	1934–1946	NUM
can-1683	356	8	.	.	PUNCT
can-1683	357	1	doi	doi	NOUN
can-1683	357	2	:	:	PUNCT
can-1683	357	3	10.1039	10.1039	NUM
can-1683	357	4	/	/	SYM
can-1683	357	5	c2sm06391c	c2sm06391c	PROPN
can-1683	357	6	.	.	PUNCT
can-1683	358	1	22	22	NUM
can-1683	358	2	.	.	PUNCT
can-1683	359	1	alam	alam	PROPN
can-1683	359	2	sr	sr	PROPN
can-1683	359	3	,	,	PUNCT
can-1683	359	4	stirrat	stirrat	PROPN
can-1683	359	5	c	c	PROPN
can-1683	359	6	,	,	PUNCT
can-1683	359	7	richards	richards	PROPN
can-1683	359	8	j	j	PROPN
can-1683	359	9	,	,	PUNCT
can-1683	359	10	et	et	PROPN
can-1683	359	11	al	al	PROPN
can-1683	359	12	.	.	PROPN
can-1683	359	13	vascular	vascular	NOUN
can-1683	359	14	and	and	CCONJ
can-1683	359	15	plaque	plaque	NOUN
can-1683	359	16	imaging	imaging	NOUN
can-1683	359	17	with	with	ADP
can-1683	359	18	ultrasmall	ultrasmall	PROPN
can-1683	359	19	superparamagnetic	superparamagnetic	ADJ
can-1683	359	20	particles	particle	NOUN
can-1683	359	21	of	of	ADP
can-1683	359	22	iron	iron	NOUN
can-1683	359	23	oxide	oxide	NOUN
can-1683	359	24	.	.	PUNCT
can-1683	360	1	journal	journal	NOUN
can-1683	360	2	of	of	ADP
can-1683	360	3	cardiovascular	cardiovascular	ADJ
can-1683	360	4	magnetic	magnetic	ADJ
can-1683	360	5	resonance	resonance	NOUN
can-1683	360	6	2015	2015	NUM
can-1683	360	7	;	;	PUNCT
can-1683	360	8	17	17	NUM
can-1683	360	9	:	:	SYM
can-1683	360	10	83	83	NUM
can-1683	360	11	.	.	PUNCT
can-1683	361	1	doi	doi	NOUN
can-1683	361	2	:	:	PUNCT
can-1683	361	3	10.1186	10.1186	NUM
can-1683	361	4	/	/	SYM
can-1683	361	5	s12968	s12968	NOUN
can-1683	361	6	-	-	PUNCT
can-1683	361	7	015	015	NUM
can-1683	361	8	-	-	PUNCT
can-1683	361	9	0183	0183	NUM
can-1683	361	10	-	-	PUNCT
can-1683	361	11	4	4	NUM
can-1683	361	12	.	.	NOUN
can-1683	361	13	23	23	NUM
can-1683	361	14	.	.	PUNCT
can-1683	362	1	freund	freund	PROPN
can-1683	362	2	b	b	PROPN
can-1683	362	3	,	,	PUNCT
can-1683	362	4	shapiro	shapiro	PROPN
can-1683	362	5	b.	b.	PROPN
can-1683	362	6	transport	transport	PROPN
can-1683	362	7	of	of	ADP
can-1683	362	8	particles	particle	NOUN
can-1683	362	9	by	by	ADP
can-1683	362	10	magnetic	magnetic	ADJ
can-1683	362	11	forces	force	NOUN
can-1683	362	12	and	and	CCONJ
can-1683	362	13	cellular	cellular	ADJ
can-1683	362	14	blood	blood	NOUN
can-1683	362	15	flow	flow	NOUN
can-1683	362	16	in	in	ADP
can-1683	362	17	a	a	DET
can-1683	362	18	model	model	NOUN
can-1683	362	19	microvessel	microvessel	NOUN
can-1683	362	20	.	.	PUNCT
can-1683	363	1	physics	physics	NOUN
can-1683	363	2	of	of	ADP
can-1683	363	3	fluids	fluid	NOUN
can-1683	363	4	2012	2012	NUM
can-1683	363	5	;	;	PUNCT
can-1683	363	6	24(5	24(5	NUM
can-1683	363	7	)	)	PUNCT
can-1683	363	8	.	.	PUNCT
can-1683	364	1	doi	doi	NOUN
can-1683	364	2	:	:	PUNCT
can-1683	364	3	10.1063/1.4718752	10.1063/1.4718752	NUM
can-1683	364	4	.	.	PUNCT
can-1683	365	1	24	24	NUM
can-1683	365	2	.	.	PUNCT
can-1683	366	1	matoba	matoba	PROPN
can-1683	366	2	t	t	PROPN
can-1683	366	3	,	,	PUNCT
can-1683	366	4	egashira	egashira	PROPN
can-1683	366	5	k.	k.	PROPN
can-1683	366	6	nanoparticle	nanoparticle	PROPN
can-1683	366	7	-	-	PUNCT
can-1683	366	8	mediated	mediate	VERB
can-1683	366	9	drug	drug	NOUN
can-1683	366	10	delivery	delivery	NOUN
can-1683	366	11	system	system	NOUN
can-1683	366	12	for	for	ADP
can-1683	366	13	cardiovascular	cardiovascular	ADJ
can-1683	366	14	disease	disease	NOUN
can-1683	366	15	.	.	PUNCT
can-1683	367	1	international	international	ADJ
can-1683	367	2	heart	heart	PROPN
can-1683	367	3	journal	journal	NOUN
can-1683	367	4	2014	2014	NUM
can-1683	367	5	;	;	PUNCT
can-1683	367	6	55	55	NUM
can-1683	367	7	:	:	PUNCT
can-1683	367	8	281–286	281–286	NUM
can-1683	367	9	.	.	PUNCT
can-1683	368	1	doi	doi	NOUN
can-1683	368	2	:	:	PUNCT
can-1683	368	3	10.1536	10.1536	NUM
can-1683	368	4	/	/	SYM
can-1683	368	5	ihj.14	ihj.14	NOUN
can-1683	368	6	-	-	ADJ
can-1683	368	7	150	150	NUM
can-1683	368	8	.	.	PUNCT
can-1683	369	1	25	25	NUM
can-1683	369	2	.	.	PUNCT
can-1683	370	1	glass	glass	PROPN
can-1683	370	2	ck	ck	PROPN
can-1683	370	3	,	,	PUNCT
can-1683	370	4	witztum	witztum	PROPN
can-1683	370	5	jl	jl	PROPN
can-1683	370	6	.	.	PUNCT
can-1683	370	7	atherosclerosis	atherosclerosis	NOUN
can-1683	370	8	.	.	PUNCT
can-1683	371	1	the	the	DET
can-1683	371	2	road	road	NOUN
can-1683	371	3	ahead	ahead	ADV
can-1683	371	4	.	.	PUNCT
can-1683	372	1	cell	cell	NOUN
can-1683	372	2	2001	2001	NUM
can-1683	372	3	;	;	PUNCT
can-1683	372	4	104(4	104(4	NUM
can-1683	372	5	):	):	PUNCT
can-1683	372	6	503–516	503–516	NUM
can-1683	372	7	.	.	PUNCT
can-1683	373	1	doi	doi	NOUN
can-1683	373	2	:	:	PUNCT
can-1683	373	3	10.1016	10.1016	NUM
can-1683	373	4	/	/	SYM
can-1683	373	5	s0092	s0092	PROPN
can-1683	373	6	-	-	PUNCT
can-1683	373	7	8674(01)00238	8674(01)00238	NUM
can-1683	373	8	-	-	SYM
can-1683	373	9	0	0	NUM
can-1683	373	10	.	.	NOUN
can-1683	373	11	26	26	NUM
can-1683	373	12	.	.	PUNCT
can-1683	374	1	hood	hood	PROPN
can-1683	374	2	ed	ed	NOUN
can-1683	374	3	,	,	PUNCT
can-1683	374	4	greineder	greineder	NOUN
can-1683	374	5	cf	cf	NOUN
can-1683	374	6	,	,	PUNCT
can-1683	374	7	shuvaeva	shuvaeva	PROPN
can-1683	374	8	t	t	PROPN
can-1683	374	9	,	,	PUNCT
can-1683	374	10	et	et	PROPN
can-1683	374	11	al	al	PROPN
can-1683	374	12	.	.	PROPN
can-1683	374	13	vascular	vascular	ADJ
can-1683	374	14	targeting	targeting	NOUN
can-1683	374	15	of	of	ADP
can-1683	374	16	radiolabeled	radiolabele	VERB
can-1683	374	17	liposomes	liposome	NOUN
can-1683	374	18	with	with	ADP
can-1683	374	19	bio	bio	NOUN
can-1683	374	20	-	-	ADJ
can-1683	374	21	orthogonally	orthogonally	ADV
can-1683	374	22	conjugated	conjugate	VERB
can-1683	374	23	ligands	ligand	NOUN
can-1683	374	24	:	:	PUNCT
can-1683	374	25	single	single	ADJ
can-1683	374	26	chain	chain	NOUN
can-1683	374	27	fragments	fragment	NOUN
can-1683	374	28	provide	provide	VERB
can-1683	374	29	higher	high	ADJ
can-1683	374	30	specificity	specificity	NOUN
can-1683	374	31	than	than	ADP
can-1683	374	32	antibodies	antibody	NOUN
can-1683	374	33	.	.	PUNCT
can-1683	375	1	bioconjugate	bioconjugate	NOUN
can-1683	375	2	chemistry	chemistry	NOUN
can-1683	375	3	29(11	29(11	NUM
can-1683	375	4	):	):	PUNCT
can-1683	375	5	3626	3626	NUM
can-1683	375	6	–	–	PUNCT
can-1683	375	7	3637	3637	NUM
can-1683	375	8	.	.	PUNCT
can-1683	376	1	doi	doi	NOUN
can-1683	376	2	:	:	PUNCT
can-1683	376	3	10.1021	10.1021	NUM
can-1683	376	4	/	/	SYM
can-1683	376	5	acs.bioconjchem.8b00564	acs.bioconjchem.8b00564	NOUN
can-1683	376	6	.	.	PUNCT
can-1683	377	1	27	27	NUM
can-1683	377	2	.	.	PUNCT
can-1683	378	1	paulis	paulis	PROPN
can-1683	378	2	le	le	PROPN
can-1683	378	3	,	,	PUNCT
can-1683	378	4	jacobs	jacobs	PROPN
can-1683	378	5	i	i	PRON
can-1683	378	6	,	,	PUNCT
can-1683	378	7	van	van	PROPN
can-1683	378	8	den	den	PROPN
can-1683	378	9	akker	akker	PROPN
can-1683	378	10	nm	nm	PROPN
can-1683	378	11	,	,	PUNCT
can-1683	378	12	et	et	PROPN
can-1683	378	13	al	al	PROPN
can-1683	378	14	.	.	PUNCT
can-1683	379	1	targeting	target	VERB
can-1683	379	2	of	of	ADP
can-1683	379	3	icam-1	icam-1	NUM
can-1683	379	4	on	on	ADP
can-1683	379	5	vascular	vascular	ADJ
can-1683	379	6	endothelium	endothelium	NOUN
can-1683	379	7	under	under	ADP
can-1683	379	8	static	static	ADJ
can-1683	379	9	and	and	CCONJ
can-1683	379	10	shear	shear	ADJ
can-1683	379	11	stress	stress	NOUN
can-1683	379	12	conditions	condition	NOUN
can-1683	379	13	using	use	VERB
can-1683	379	14	a	a	DET
can-1683	379	15	liposomal	liposomal	ADJ
can-1683	379	16	gd	gd	NOUN
can-1683	379	17	-	-	PUNCT
can-1683	379	18	based	base	VERB
can-1683	379	19	mri	mri	NOUN
can-1683	379	20	contrast	contrast	NOUN
can-1683	379	21	agent	agent	NOUN
can-1683	379	22	.	.	PUNCT
can-1683	380	1	journal	journal	NOUN
can-1683	380	2	of	of	ADP
can-1683	380	3	nanobiotechnology	nanobiotechnology	NOUN
can-1683	380	4	2012	2012	NUM
can-1683	380	5	;	;	PUNCT
can-1683	380	6	10	10	NUM
can-1683	380	7	:	:	SYM
can-1683	380	8	25	25	NUM
can-1683	380	9	.	.	PUNCT
can-1683	381	1	doi	doi	NOUN
can-1683	381	2	:	:	PUNCT
can-1683	381	3	10.1186/1477	10.1186/1477	NUM
can-1683	381	4	-	-	SYM
can-1683	381	5	3155	3155	NUM
can-1683	381	6	-	-	SYM
can-1683	381	7	10	10	NUM
can-1683	381	8	-	-	SYM
can-1683	381	9	25	25	NUM
can-1683	381	10	.	.	PUNCT
can-1683	382	1	28	28	NUM
can-1683	382	2	.	.	PUNCT
can-1683	383	1	ma	ma	PROPN
can-1683	383	2	s	s	PROPN
can-1683	383	3	,	,	PUNCT
can-1683	383	4	tian	tian	PROPN
can-1683	383	5	xy	xy	PROPN
can-1683	383	6	,	,	PUNCT
can-1683	383	7	zhang	zhang	PROPN
can-1683	383	8	y	y	PROPN
can-1683	383	9	,	,	PUNCT
can-1683	383	10	et	et	PROPN
can-1683	383	11	al	al	PROPN
can-1683	383	12	.	.	PUNCT
can-1683	384	1	e	e	X
can-1683	384	2	-	-	NOUN
can-1683	384	3	selectin	selectin	ADV
can-1683	384	4	-	-	PUNCT
can-1683	384	5	targeting	target	VERB
can-1683	384	6	delivery	delivery	NOUN
can-1683	384	7	of	of	ADP
can-1683	384	8	micrornas	microrna	NOUN
can-1683	384	9	by	by	ADP
can-1683	384	10	microparticles	microparticle	NOUN
can-1683	384	11	ameliorates	ameliorate	VERB
can-1683	384	12	endothelial	endothelial	ADJ
can-1683	384	13	inflammation	inflammation	NOUN
can-1683	384	14	and	and	CCONJ
can-1683	384	15	atherosclerosis	atherosclerosis	NOUN
can-1683	384	16	.	.	PUNCT
can-1683	385	1	scientific	scientific	ADJ
can-1683	385	2	reports	report	NOUN
can-1683	385	3	2016	2016	NUM
can-1683	385	4	;	;	PUNCT
can-1683	385	5	6	6	NUM
can-1683	385	6	:	:	SYM
can-1683	385	7	22910	22910	NUM
can-1683	385	8	.	.	PUNCT
can-1683	386	1	doi	doi	NOUN
can-1683	386	2	:	:	PUNCT
can-1683	386	3	10.1038	10.1038	NUM
can-1683	386	4	/	/	SYM
can-1683	386	5	srep22910	srep22910	PROPN
can-1683	386	6	.	.	PUNCT
can-1683	387	1	29	29	NUM
can-1683	387	2	.	.	X
can-1683	387	3	flaht	flaht	NOUN
can-1683	387	4	-	-	PUNCT
can-1683	387	5	zabost	zabost	NOUN
can-1683	387	6	a	a	NOUN
can-1683	387	7	,	,	PUNCT
can-1683	387	8	gula	gula	PROPN
can-1683	387	9	g	g	PROPN
can-1683	387	10	,	,	PUNCT
can-1683	387	11	ciszek	ciszek	ADJ
can-1683	387	12	b	b	NOUN
can-1683	387	13	,	,	PUNCT
can-1683	387	14	et	et	PROPN
can-1683	388	1	al	al	PROPN
can-1683	388	2	.	.	PUNCT
can-1683	388	3	cardiac	cardiac	PROPN
can-1683	388	4	mouse	mouse	PROPN
can-1683	388	5	lymphatics	lymphatic	NOUN
can-1683	388	6	:	:	PUNCT
can-1683	388	7	developmental	developmental	ADJ
can-1683	388	8	and	and	CCONJ
can-1683	388	9	anatomical	anatomical	ADJ
can-1683	388	10	update	update	NOUN
can-1683	388	11	.	.	PUNCT
can-1683	389	1	anatomical	anatomical	ADJ
can-1683	389	2	record	record	NOUN
can-1683	389	3	2014	2014	NUM
can-1683	389	4	;	;	PUNCT
can-1683	389	5	297(6	297(6	NUM
can-1683	389	6	):	):	PUNCT
can-1683	389	7	1115	1115	NUM
can-1683	389	8	–	–	PUNCT
can-1683	389	9	1130	1130	NUM
can-1683	389	10	.	.	PUNCT
can-1683	390	1	doi	doi	NOUN
can-1683	390	2	:	:	PUNCT
can-1683	390	3	10.1002	10.1002	NUM
can-1683	390	4	/	/	SYM
can-1683	390	5	ar.22912	ar.22912	PROPN
can-1683	390	6	.	.	PUNCT
can-1683	391	1	30	30	NUM
can-1683	391	2	.	.	PUNCT
can-1683	392	1	dvir	dvir	PROPN
can-1683	392	2	t	t	PROPN
can-1683	392	3	,	,	PUNCT
can-1683	392	4	bauer	bauer	PROPN
can-1683	392	5	m	m	PROPN
can-1683	392	6	,	,	PUNCT
can-1683	392	7	schroeder	schroeder	PROPN
can-1683	392	8	a	a	PROPN
can-1683	392	9	,	,	PUNCT
can-1683	392	10	et	et	PROPN
can-1683	392	11	al	al	PROPN
can-1683	392	12	.	.	PROPN
can-1683	393	1	nanoparticles	nanoparticle	NOUN
can-1683	393	2	targeting	target	VERB
can-1683	393	3	the	the	DET
can-1683	393	4	infarcted	infarcted	ADJ
can-1683	393	5	heart	heart	NOUN
can-1683	393	6	.	.	PUNCT
can-1683	394	1	nano	nano	NOUN
can-1683	394	2	letters	letter	NOUN
can-1683	394	3	2011	2011	NUM
can-1683	394	4	;	;	PUNCT
can-1683	394	5	11(10	11(10	NUM
can-1683	394	6	):	):	PUNCT
can-1683	394	7	4411–4414	4411–4414	NUM
can-1683	394	8	.	.	PUNCT
can-1683	394	9	doi	doi	NOUN
can-1683	394	10	:	:	PUNCT
can-1683	394	11	10.1021	10.1021	NUM
can-1683	394	12	/	/	SYM
can-1683	394	13	nl2025882	nl2025882	PROPN
can-1683	394	14	.	.	PUNCT
can-1683	395	1	31	31	NUM
can-1683	395	2	.	.	PUNCT
can-1683	396	1	lee	lee	PROPN
can-1683	396	2	gy	gy	PROPN
can-1683	396	3	,	,	PUNCT
can-1683	396	4	kim	kim	PROPN
can-1683	396	5	jh	jh	PROPN
can-1683	396	6	,	,	PUNCT
can-1683	396	7	choi	choi	PROPN
can-1683	396	8	ky	ky	PROPN
can-1683	396	9	,	,	PUNCT
can-1683	396	10	et	et	PROPN
can-1683	396	11	al	al	PROPN
can-1683	396	12	.	.	PROPN
can-1683	396	13	hyaluronic	hyaluronic	ADJ
can-1683	396	14	acid	acid	NOUN
can-1683	396	15	nanoparticles	nanoparticle	NOUN
can-1683	396	16	for	for	ADP
can-1683	396	17	active	active	ADJ
can-1683	396	18	targeting	targeting	NOUN
can-1683	396	19	atherosclerosis	atherosclerosis	NOUN
can-1683	396	20	.	.	PUNCT
can-1683	397	1	biomaterials	biomaterial	NOUN
can-1683	397	2	2015	2015	NUM
can-1683	397	3	;	;	PUNCT
can-1683	398	1	53	53	NUM
can-1683	398	2	:	:	PUNCT
can-1683	398	3	341–348	341–348	NUM
can-1683	398	4	.	.	PUNCT
can-1683	398	5	doi	doi	NOUN
can-1683	398	6	:	:	PUNCT
can-1683	398	7	10.1016	10.1016	NUM
can-1683	398	8	/	/	SYM
can-1683	398	9	j.biomaterials.2015.02.089	j.biomaterials.2015.02.089	NOUN
can-1683	398	10	.	.	PROPN
can-1683	399	1	32	32	NUM
can-1683	399	2	.	.	PUNCT
can-1683	400	1	kamaly	kamaly	PROPN
can-1683	400	2	n	n	PROPN
can-1683	400	3	,	,	PUNCT
can-1683	400	4	fredman	fredman	PROPN
can-1683	400	5	g	g	PROPN
can-1683	400	6	,	,	PUNCT
can-1683	400	7	fojas	fojas	PROPN
can-1683	400	8	jj	jj	PROPN
can-1683	400	9	,	,	PUNCT
can-1683	400	10	et	et	PROPN
can-1683	400	11	al	al	PROPN
can-1683	400	12	.	.	PROPN
can-1683	400	13	targeted	target	VERB
can-1683	400	14	interleukin-10	interleukin-10	ADJ
can-1683	400	15	nanotherapeutics	nanotherapeutic	NOUN
can-1683	400	16	developed	develop	VERB
can-1683	400	17	with	with	ADP
can-1683	400	18	a	a	DET
can-1683	400	19	microfluidic	microfluidic	ADJ
can-1683	400	20	chip	chip	NOUN
can-1683	400	21	enhance	enhance	NOUN
can-1683	400	22	resolution	resolution	NOUN
can-1683	400	23	of	of	ADP
can-1683	400	24	inflammation	inflammation	NOUN
can-1683	400	25	in	in	ADP
can-1683	400	26	advanced	advanced	ADJ
can-1683	400	27	atherosclerosis	atherosclerosis	NOUN
can-1683	400	28	.	.	PUNCT
can-1683	401	1	acs	acs	PROPN
can-1683	401	2	nano	nano	PROPN
can-1683	401	3	2016	2016	NUM
can-1683	401	4	;	;	PUNCT
can-1683	401	5	10(5	10(5	NUM
can-1683	401	6	):	):	PUNCT
can-1683	401	7	5280–5292	5280–5292	NUM
can-1683	401	8	.	.	PUNCT
can-1683	402	1	doi	doi	NOUN
can-1683	402	2	:	:	PUNCT
can-1683	402	3	10.1021	10.1021	NUM
can-1683	402	4	/	/	SYM
can-1683	402	5	acsnano.6b01114	acsnano.6b01114	PROPN
can-1683	402	6	.	.	PUNCT
can-1683	403	1	33	33	NUM
can-1683	403	2	.	.	PUNCT
can-1683	403	3	anselmo	anselmo	VERB
can-1683	403	4	ac	ac	PROPN
can-1683	403	5	,	,	PUNCT
can-1683	403	6	modery	modery	NOUN
can-1683	403	7	-	-	PUNCT
can-1683	403	8	pawlowski	pawlowski	NOUN
can-1683	403	9	cl	cl	NOUN
can-1683	403	10	,	,	PUNCT
can-1683	403	11	menegatti	menegatti	NOUN
can-1683	403	12	s	s	PROPN
can-1683	403	13	,	,	PUNCT
can-1683	403	14	et	et	PROPN
can-1683	403	15	al	al	PROPN
can-1683	403	16	.	.	PUNCT
can-1683	404	1	platelet	platelet	NOUN
can-1683	404	2	-	-	PUNCT
can-1683	404	3	like	like	ADJ
can-1683	404	4	nanoparticles	nanoparticle	NOUN
can-1683	404	5	:	:	PUNCT
can-1683	404	6	mimicking	mimic	VERB
can-1683	404	7	shape	shape	NOUN
can-1683	404	8	,	,	PUNCT
can-1683	404	9	flexibility	flexibility	NOUN
can-1683	404	10	,	,	PUNCT
can-1683	404	11	and	and	CCONJ
can-1683	404	12	surface	surface	NOUN
can-1683	404	13	biology	biology	NOUN
can-1683	404	14	of	of	ADP
can-1683	404	15	platelets	platelet	NOUN
can-1683	404	16	to	to	PART
can-1683	404	17	target	target	VERB
can-1683	404	18	vascular	vascular	ADJ
can-1683	404	19	injuries	injury	NOUN
can-1683	404	20	.	.	PUNCT
can-1683	405	1	acs	acs	PROPN
can-1683	405	2	nano	nano	PROPN
can-1683	405	3	2014	2014	NUM
can-1683	405	4	;	;	PUNCT
can-1683	405	5	8(11	8(11	NUM
can-1683	405	6	):	):	PUNCT
can-1683	405	7	11243	11243	NUM
can-1683	405	8	–	–	PUNCT
can-1683	405	9	11253	11253	NUM
can-1683	405	10	.	.	PUNCT
can-1683	406	1	doi	doi	NOUN
can-1683	406	2	:	:	PUNCT
can-1683	406	3	10.1021	10.1021	NUM
can-1683	406	4	/	/	SYM
can-1683	406	5	nn503732	nn503732	PROPN
can-1683	406	6	m.	m.	NOUN
can-1683	406	7	34	34	NUM
can-1683	406	8	.	.	PUNCT
can-1683	407	1	charoenphol	charoenphol	PROPN
can-1683	407	2	p	p	X
can-1683	407	3	,	,	PUNCT
can-1683	407	4	mocherla	mocherla	PROPN
can-1683	407	5	s	s	PROPN
can-1683	407	6	,	,	PUNCT
can-1683	407	7	bouis	bouis	PROPN
can-1683	408	1	d	d	NOUN
can-1683	408	2	,	,	PUNCT
can-1683	408	3	et	et	PROPN
can-1683	408	4	al	al	PROPN
can-1683	408	5	.	.	PUNCT
can-1683	408	6	targeting	target	VERB
can-1683	408	7	therapeutics	therapeutic	NOUN
can-1683	408	8	to	to	ADP
can-1683	408	9	the	the	DET
can-1683	408	10	vascular	vascular	ADJ
can-1683	408	11	wall	wall	NOUN
can-1683	408	12	in	in	ADP
can-1683	408	13	atherosclerosis	atherosclerosis	NOUN
can-1683	408	14	—	—	PUNCT
can-1683	408	15	carrier	carrier	NOUN
can-1683	408	16	size	size	NOUN
can-1683	408	17	matters	matter	NOUN
can-1683	408	18	.	.	PUNCT
can-1683	409	1	atherosclerosis	atherosclerosis	NOUN
can-1683	409	2	2011	2011	NUM
can-1683	409	3	;	;	PUNCT
can-1683	409	4	217(2	217(2	NUM
can-1683	409	5	):	):	PUNCT
can-1683	409	6	364–370	364–370	NUM
can-1683	409	7	.	.	PUNCT
can-1683	410	1	doi	doi	NOUN
can-1683	410	2	:	:	PUNCT
can-1683	410	3	10.1016	10.1016	NUM
can-1683	410	4	/	/	SYM
can-1683	410	5	j.atherosclerosis.2011.04.016	j.atherosclerosis.2011.04.016	PROPN
can-1683	410	6	.	.	PUNCT
can-1683	411	1	35	35	NUM
can-1683	411	2	.	.	PUNCT
can-1683	412	1	corot	corot	PROPN
can-1683	412	2	c	c	X
can-1683	412	3	,	,	PUNCT
can-1683	412	4	robert	robert	PROPN
can-1683	412	5	p	p	PROPN
can-1683	412	6	,	,	PUNCT
can-1683	412	7	idee	idee	PROPN
can-1683	412	8	jm	jm	PROPN
can-1683	412	9	,	,	PUNCT
can-1683	412	10	et	et	PROPN
can-1683	412	11	al	al	PROPN
can-1683	412	12	.	.	PUNCT
can-1683	413	1	recent	recent	ADJ
can-1683	413	2	advances	advance	NOUN
can-1683	413	3	in	in	ADP
can-1683	413	4	iron	iron	NOUN
can-1683	413	5	oxide	oxide	NOUN
can-1683	413	6	nanocrystal	nanocrystal	ADJ
can-1683	413	7	technology	technology	NOUN
can-1683	413	8	for	for	ADP
can-1683	413	9	medical	medical	ADJ
can-1683	413	10	imaging	imaging	NOUN
can-1683	413	11	.	.	PUNCT
can-1683	414	1	advanced	advanced	ADJ
can-1683	414	2	drug	drug	NOUN
can-1683	414	3	delivery	delivery	NOUN
can-1683	414	4	reviews	review	NOUN
can-1683	414	5	2006	2006	NUM
can-1683	414	6	;	;	PUNCT
can-1683	414	7	58(14	58(14	NOUN
can-1683	414	8	):	):	PUNCT
can-1683	414	9	1471–1504	1471–1504	NUM
can-1683	414	10	.	.	PUNCT
can-1683	415	1	doi	doi	NOUN
can-1683	415	2	:	:	PUNCT
can-1683	415	3	10.1016	10.1016	NUM
can-1683	415	4	/	/	SYM
can-1683	415	5	j.addr.2006.09.013	j.addr.2006.09.013	PROPN
can-1683	415	6	.	.	PUNCT
can-1683	416	1	36	36	NUM
can-1683	416	2	.	.	X
can-1683	417	1	yoo	yoo	PROPN
can-1683	417	2	sp	sp	PROPN
can-1683	417	3	,	,	PUNCT
can-1683	417	4	pineda	pineda	PROPN
can-1683	417	5	f	f	PROPN
can-1683	417	6	,	,	PUNCT
can-1683	417	7	barrett	barrett	PROPN
can-1683	417	8	jc	jc	PROPN
can-1683	417	9	,	,	PUNCT
can-1683	417	10	et	et	PROPN
can-1683	417	11	al	al	PROPN
can-1683	417	12	.	.	PUNCT
can-1683	417	13	gadolinium	gadolinium	NOUN
can-1683	417	14	-	-	PUNCT
can-1683	417	15	functionalized	functionalize	VERB
can-1683	417	16	peptide	peptide	NOUN
can-1683	417	17	amphiphile	amphiphile	ADP
can-1683	417	18	micelles	micelle	NOUN
can-1683	417	19	for	for	ADP
can-1683	417	20	multimodal	multimodal	ADJ
can-1683	417	21	imaging	imaging	NOUN
can-1683	417	22	of	of	ADP
can-1683	417	23	atherosclerotic	atherosclerotic	ADJ
can-1683	417	24	lesions	lesion	NOUN
can-1683	417	25	.	.	PUNCT
can-1683	418	1	acs	acs	PROPN
can-1683	418	2	omega	omega	NOUN
can-1683	418	3	2016	2016	NUM
can-1683	418	4	;	;	PUNCT
can-1683	418	5	1(5	1(5	NUM
can-1683	418	6	):	):	PUNCT
can-1683	418	7	996–1003	996–1003	NUM
can-1683	418	8	.	.	PUNCT
can-1683	419	1	doi	doi	NOUN
can-1683	419	2	:	:	PUNCT
can-1683	419	3	10.1021	10.1021	NUM
can-1683	419	4	/	/	SYM
can-1683	419	5	acsomega.6b00210	acsomega.6b00210	NOUN
can-1683	419	6	.	.	PUNCT
can-1683	420	1	37	37	NUM
can-1683	420	2	.	.	PUNCT
can-1683	420	3	winter	winter	NOUN
can-1683	420	4	pm	pm	PROPN
can-1683	420	5	,	,	PUNCT
can-1683	420	6	caruthers	caruther	NOUN
can-1683	420	7	sd	sd	PROPN
can-1683	420	8	,	,	PUNCT
can-1683	420	9	zhang	zhang	PROPN
can-1683	420	10	h	h	PROPN
can-1683	420	11	,	,	PUNCT
can-1683	420	12	et	et	PROPN
can-1683	420	13	al	al	PROPN
can-1683	420	14	.	.	PUNCT
can-1683	420	15	antiangiogenic	antiangiogenic	ADJ
can-1683	420	16	synergism	synergism	NOUN
can-1683	420	17	of	of	ADP
can-1683	420	18	integrin	integrin	NOUN
can-1683	420	19	-	-	PUNCT
can-1683	420	20	targeted	target	VERB
can-1683	420	21	fumagillin	fumagillin	NOUN
can-1683	420	22	nanoparticles	nanoparticle	NOUN
can-1683	420	23	and	and	CCONJ
can-1683	420	24	atorvastatin	atorvastatin	NOUN
can-1683	420	25	in	in	ADP
can-1683	420	26	atherosclerosis	atherosclerosis	NOUN
can-1683	420	27	.	.	PUNCT
can-1683	421	1	jacc	jacc	VERB
can-1683	421	2	:	:	PUNCT
can-1683	421	3	cardiovascular	cardiovascular	ADJ
can-1683	421	4	imaging	imaging	NOUN
can-1683	421	5	2008	2008	NUM
can-1683	421	6	;	;	PUNCT
can-1683	421	7	1(5	1(5	NUM
can-1683	421	8	):	):	PUNCT
can-1683	421	9	624–634	624–634	NUM
can-1683	421	10	.	.	PUNCT
can-1683	422	1	doi	doi	NOUN
can-1683	422	2	:	:	PUNCT
can-1683	422	3	10.1016	10.1016	NUM
can-1683	422	4	/	/	SYM
can-1683	422	5	j.jcmg.2008.06.003	j.jcmg.2008.06.003	PROPN
can-1683	422	6	.	.	PROPN
can-1683	422	7	38	38	NUM
can-1683	422	8	.	.	PUNCT
can-1683	423	1	mottu	mottu	PROPN
can-1683	423	2	f	f	NOUN
can-1683	423	3	,	,	PUNCT
can-1683	423	4	rüfenacht	rüfenacht	NOUN
can-1683	423	5	da	da	PROPN
can-1683	423	6	,	,	PUNCT
can-1683	423	7	laurent	laurent	NOUN
can-1683	423	8	a	a	PROPN
can-1683	423	9	,	,	PUNCT
can-1683	423	10	et	et	PROPN
can-1683	423	11	al	al	PROPN
can-1683	423	12	.	.	PROPN
can-1683	423	13	iodine	iodine	NOUN
can-1683	423	14	-	-	PUNCT
can-1683	423	15	containing	contain	VERB
can-1683	423	16	cellulose	cellulose	NOUN
can-1683	423	17	mixed	mixed	ADJ
can-1683	423	18	esters	ester	NOUN
can-1683	423	19	as	as	ADP
can-1683	423	20	radiopaque	radiopaque	NOUN
can-1683	423	21	polymers	polymer	NOUN
can-1683	423	22	for	for	ADP
can-1683	423	23	direct	direct	ADJ
can-1683	423	24	embolization	embolization	NOUN
can-1683	423	25	of	of	ADP
can-1683	423	26	cerebral	cerebral	ADJ
can-1683	423	27	aneurysms	aneurysm	NOUN
can-1683	423	28	and	and	CCONJ
can-1683	423	29	arteriovenous	arteriovenous	ADJ
can-1683	423	30	malformations	malformation	NOUN
can-1683	423	31	.	.	PUNCT
can-1683	424	1	biomaterials	biomaterial	NOUN
can-1683	424	2	2002	2002	NUM
can-1683	424	3	;	;	PUNCT
can-1683	424	4	23(1	23(1	NUM
can-1683	424	5	):	):	PUNCT
can-1683	424	6	121–131	121–131	NUM
can-1683	424	7	.	.	PUNCT
can-1683	425	1	doi	doi	NOUN
can-1683	425	2	:	:	PUNCT
can-1683	425	3	10.1016	10.1016	NUM
can-1683	425	4	/	/	SYM
can-1683	425	5	s0142	s0142	PROPN
can-1683	425	6	-	-	PUNCT
can-1683	425	7	9612(01)00087	9612(01)00087	NUM
can-1683	425	8	-	-	PUNCT
can-1683	425	9	4	4	NUM
can-1683	425	10	.	.	NOUN
can-1683	425	11	39	39	NUM
can-1683	425	12	.	.	PUNCT
can-1683	426	1	alie	alie	PROPN
can-1683	426	2	n	n	CCONJ
can-1683	426	3	,	,	PUNCT
can-1683	426	4	eldib	eldib	NOUN
can-1683	426	5	m	m	PROPN
can-1683	426	6	,	,	PUNCT
can-1683	426	7	fayad	fayad	PROPN
can-1683	426	8	za	za	PROPN
can-1683	426	9	,	,	PUNCT
can-1683	426	10	et	et	PROPN
can-1683	426	11	al	al	PROPN
can-1683	426	12	.	.	PROPN
can-1683	426	13	inflammation	inflammation	NOUN
can-1683	426	14	,	,	PUNCT
can-1683	426	15	atherosclerosis	atherosclerosis	NOUN
can-1683	426	16	,	,	PUNCT
can-1683	426	17	and	and	CCONJ
can-1683	426	18	coronary	coronary	ADJ
can-1683	426	19	artery	artery	NOUN
can-1683	426	20	disease	disease	NOUN
can-1683	426	21	:	:	PUNCT
can-1683	426	22	pet	pet	NOUN
can-1683	426	23	/	/	SYM
can-1683	426	24	ct	ct	PROPN
can-1683	426	25	for	for	ADP
can-1683	426	26	the	the	DET
can-1683	426	27	evaluation	evaluation	NOUN
can-1683	426	28	of	of	ADP
can-1683	426	29	atherosclerosis	atherosclerosis	NOUN
can-1683	426	30	and	and	CCONJ
can-1683	426	31	inflammation	inflammation	NOUN
can-1683	426	32	.	.	PUNCT
can-1683	427	1	clinical	clinical	ADJ
can-1683	427	2	medicine	medicine	NOUN
can-1683	427	3	insights	insight	NOUN
can-1683	427	4	:	:	PUNCT
can-1683	427	5	cardiology	cardiology	NOUN
can-1683	427	6	2015	2015	NUM
can-1683	427	7	;	;	PUNCT
can-1683	427	8	8(suppl	8(suppl	PROPN
can-1683	427	9	3	3	NUM
can-1683	427	10	):	):	PUNCT
can-1683	428	1	13–21	13–21	NUM
can-1683	428	2	.	.	PUNCT
can-1683	428	3	doi	doi	NOUN
can-1683	428	4	:	:	PUNCT
can-1683	428	5	10.4137	10.4137	NUM
can-1683	428	6	/	/	SYM
can-1683	428	7	cmc.s17063	cmc.s17063	NOUN
can-1683	428	8	.	.	PUNCT
can-1683	429	1	40	40	NUM
can-1683	429	2	.	.	PUNCT
can-1683	430	1	chhour	chhour	NOUN
can-1683	430	2	p	p	X
can-1683	430	3	,	,	PUNCT
can-1683	430	4	naha	naha	NOUN
can-1683	430	5	pc	pc	NOUN
can-1683	430	6	,	,	PUNCT
can-1683	430	7	o’neill	o’neill	PROPN
can-1683	430	8	sm	sm	PROPN
can-1683	430	9	,	,	PUNCT
can-1683	430	10	et	et	PROPN
can-1683	430	11	al	al	PROPN
can-1683	430	12	.	.	PROPN
can-1683	430	13	labeling	labeling	NOUN
can-1683	430	14	monocytes	monocyte	VERB
can-1683	430	15	with	with	ADP
can-1683	430	16	gold	gold	ADJ
can-1683	430	17	nanoparticles	nanoparticle	NOUN
can-1683	430	18	to	to	PART
can-1683	430	19	track	track	VERB
can-1683	430	20	their	their	PRON
can-1683	430	21	recruitment	recruitment	NOUN
can-1683	430	22	in	in	ADP
can-1683	430	23	atherosclerosis	atherosclerosis	NOUN
can-1683	430	24	with	with	ADP
can-1683	430	25	computed	compute	VERB
can-1683	430	26	tomography	tomography	NOUN
can-1683	430	27	.	.	PUNCT
can-1683	431	1	biomaterials	biomaterial	NOUN
can-1683	431	2	2016	2016	NUM
can-1683	431	3	;	;	PUNCT
can-1683	431	4	87	87	NUM
can-1683	431	5	:	:	PUNCT
can-1683	431	6	93–103	93–103	X
can-1683	431	7	.	.	PUNCT
can-1683	431	8	doi	doi	NOUN
can-1683	431	9	:	:	PUNCT
can-1683	431	10	10.1016	10.1016	NUM
can-1683	431	11	/	/	SYM
can-1683	431	12	j.biomaterials.2016.02.009	j.biomaterials.2016.02.009	PROPN
can-1683	431	13	.	.	PROPN
can-1683	431	14	41	41	NUM
can-1683	431	15	.	.	PUNCT
can-1683	432	1	wang	wang	PROPN
can-1683	432	2	y	y	PROPN
can-1683	432	3	,	,	PUNCT
can-1683	432	4	chen	chen	PROPN
can-1683	432	5	j	j	PROPN
can-1683	432	6	,	,	PUNCT
can-1683	432	7	yang	yang	PROPN
can-1683	432	8	b	b	PROPN
can-1683	432	9	,	,	PUNCT
can-1683	432	10	et	et	PROPN
can-1683	432	11	al	al	PROPN
can-1683	432	12	.	.	PROPN
can-1683	433	1	in	in	ADP
can-1683	433	2	vivo	vivo	NOUN
can-1683	433	3	mr	mr	PROPN
can-1683	433	4	and	and	CCONJ
can-1683	433	5	fluorescence	fluorescence	ADJ
can-1683	433	6	dual	dual	ADJ
can-1683	433	7	-	-	PUNCT
can-1683	433	8	modality	modality	NOUN
can-1683	433	9	imaging	imaging	NOUN
can-1683	433	10	of	of	ADP
can-1683	433	11	atherosclerosis	atherosclerosis	NOUN
can-1683	433	12	characteristics	characteristic	NOUN
can-1683	433	13	in	in	ADP
can-1683	433	14	mice	mouse	NOUN
can-1683	433	15	using	use	VERB
can-1683	433	16	profilin-1	profilin-1	NUM
can-1683	433	17	targeted	target	VERB
can-1683	433	18	magnetic	magnetic	ADJ
can-1683	433	19	nanoparticles	nanoparticle	NOUN
can-1683	433	20	.	.	PUNCT
can-1683	434	1	theranostics	theranostic	NOUN
can-1683	434	2	2016	2016	NUM
can-1683	434	3	;	;	PUNCT
can-1683	434	4	6(2	6(2	NUM
can-1683	434	5	):	):	PUNCT
can-1683	434	6	22	22	NUM
can-1683	434	7	272–286	272–286	NUM
can-1683	434	8	.	.	PUNCT
can-1683	435	1	doi	doi	NOUN
can-1683	435	2	:	:	PUNCT
can-1683	435	3	10.7150	10.7150	NUM
can-1683	435	4	/	/	SYM
can-1683	435	5	thno.13350	thno.13350	PROPN
can-1683	435	6	.	.	PROPN
can-1683	435	7	42	42	NUM
can-1683	435	8	.	.	PUNCT
can-1683	436	1	marsh	marsh	PROPN
can-1683	436	2	jn	jn	PROPN
can-1683	436	3	,	,	PUNCT
can-1683	436	4	senpan	senpan	VERB
can-1683	436	5	a	a	PRON
can-1683	436	6	,	,	PUNCT
can-1683	436	7	hu	hu	PROPN
can-1683	436	8	g	g	PROPN
can-1683	436	9	,	,	PUNCT
can-1683	436	10	et	et	PROPN
can-1683	437	1	al	al	PROPN
can-1683	437	2	.	.	PROPN
can-1683	437	3	fibrin	fibrin	NOUN
can-1683	437	4	-	-	PUNCT
can-1683	437	5	targeted	target	VERB
can-1683	437	6	perfluorocarbon	perfluorocarbon	NOUN
can-1683	437	7	nanoparticles	nanoparticle	NOUN
can-1683	437	8	for	for	ADP
can-1683	437	9	targeted	target	VERB
can-1683	437	10	thrombolysis	thrombolysis	NOUN
can-1683	437	11	.	.	PUNCT
can-1683	438	1	nanomedicine	nanomedicine	NOUN
can-1683	438	2	2007	2007	NUM
can-1683	438	3	;	;	PUNCT
can-1683	438	4	2(4	2(4	NUM
can-1683	438	5	):	):	PUNCT
can-1683	438	6	533–543	533–543	NUM
can-1683	438	7	.	.	PUNCT
can-1683	438	8	doi	doi	NOUN
can-1683	438	9	:	:	PUNCT
can-1683	438	10	10.2217/17435889.2.4.533	10.2217/17435889.2.4.533	NUM
can-1683	438	11	.	.	PUNCT
can-1683	439	1	43	43	NUM
can-1683	439	2	.	.	PUNCT
can-1683	440	1	yang	yang	PROPN
can-1683	440	2	x	x	PROPN
can-1683	440	3	,	,	PUNCT
can-1683	440	4	hong	hong	PROPN
can-1683	440	5	h	h	NOUN
can-1683	440	6	,	,	PUNCT
can-1683	440	7	grailer	grailer	PROPN
can-1683	440	8	jj	jj	PROPN
can-1683	440	9	,	,	PUNCT
can-1683	440	10	et	et	PROPN
can-1683	440	11	al	al	PROPN
can-1683	440	12	.	.	PUNCT
can-1683	440	13	crgd	crgd	NOUN
can-1683	440	14	-	-	PUNCT
can-1683	440	15	functionalized	functionalize	VERB
can-1683	440	16	,	,	PUNCT
can-1683	440	17	dox	dox	NOUN
can-1683	440	18	-	-	PUNCT
can-1683	440	19	conjugated	conjugate	VERB
can-1683	440	20	,	,	PUNCT
can-1683	440	21	and	and	CCONJ
can-1683	440	22	64cu	64cu	ADV
can-1683	440	23	-	-	PUNCT
can-1683	440	24	labeled	label	VERB
can-1683	440	25	superparamagnetic	superparamagnetic	ADJ
can-1683	440	26	iron	iron	NOUN
can-1683	440	27	oxide	oxide	NOUN
can-1683	440	28	nanoparticles	nanoparticle	NOUN
can-1683	440	29	for	for	ADP
can-1683	440	30	targeted	target	VERB
can-1683	440	31	anticancer	anticancer	NOUN
can-1683	440	32	drug	drug	NOUN
can-1683	440	33	delivery	delivery	NOUN
can-1683	440	34	and	and	CCONJ
can-1683	440	35	pet	pet	NOUN
can-1683	440	36	/	/	SYM
can-1683	440	37	mr	mr	PROPN
can-1683	440	38	imaging	imaging	PROPN
can-1683	440	39	.	.	PUNCT
can-1683	441	1	biomaterials	biomaterial	NOUN
can-1683	441	2	2011	2011	NUM
can-1683	441	3	;	;	PUNCT
can-1683	441	4	32(17	32(17	NUM
can-1683	441	5	):	):	PUNCT
can-1683	441	6	4151	4151	NUM
can-1683	441	7	–	–	PUNCT
can-1683	441	8	4160	4160	NUM
can-1683	441	9	.	.	PUNCT
can-1683	442	1	doi	doi	NOUN
can-1683	442	2	:	:	PUNCT
can-1683	442	3	10.1016	10.1016	NUM
can-1683	442	4	/	/	SYM
can-1683	442	5	j.biomaterials.2011.02.006	j.biomaterials.2011.02.006	PROPN
can-1683	442	6	.	.	PROPN
can-1683	443	1	44	44	NUM
can-1683	443	2	.	.	PUNCT
can-1683	444	1	chen	chen	PROPN
can-1683	444	2	j	j	PROPN
can-1683	444	3	,	,	PUNCT
can-1683	444	4	sun	sun	PROPN
can-1683	444	5	y	y	PROPN
can-1683	444	6	,	,	PUNCT
can-1683	444	7	chen	chen	PROPN
can-1683	444	8	q	q	PROPN
can-1683	444	9	,	,	PUNCT
can-1683	444	10	et	et	PROPN
can-1683	444	11	al	al	PROPN
can-1683	444	12	.	.	PUNCT
can-1683	444	13	multifunctional	multifunctional	ADJ
can-1683	444	14	gold	gold	NOUN
can-1683	444	15	nanocomposites	nanocomposite	NOUN
can-1683	444	16	designed	design	VERB
can-1683	444	17	for	for	ADP
can-1683	444	18	targeted	target	VERB
can-1683	444	19	ct	ct	PROPN
can-1683	444	20	/	/	SYM
can-1683	444	21	mr	mr	PROPN
can-1683	444	22	/	/	SYM
can-1683	444	23	optical	optical	ADJ
can-1683	444	24	trimodal	trimodal	NOUN
can-1683	444	25	imaging	imaging	NOUN
can-1683	444	26	of	of	ADP
can-1683	444	27	human	human	ADJ
can-1683	444	28	non	non	ADJ
can-1683	444	29	-	-	ADJ
can-1683	444	30	small	small	ADJ
can-1683	444	31	cell	cell	NOUN
can-1683	444	32	lung	lung	NOUN
can-1683	444	33	cancer	cancer	NOUN
can-1683	444	34	cells	cell	NOUN
can-1683	444	35	.	.	PUNCT
can-1683	445	1	nanoscale	nanoscale	PROPN
can-1683	445	2	2016	2016	NUM
can-1683	445	3	;	;	PUNCT
can-1683	445	4	8(28	8(28	NUM
can-1683	445	5	):	):	PUNCT
can-1683	445	6	13568–13573	13568–13573	NUM
can-1683	445	7	.	.	PUNCT
can-1683	445	8	doi	doi	NOUN
can-1683	445	9	:	:	PUNCT
can-1683	445	10	10.1039	10.1039	NUM
can-1683	445	11	/	/	SYM
can-1683	445	12	c6nr03143a	c6nr03143a	PROPN
can-1683	445	13	.	.	PROPN
can-1683	446	1	45	45	NUM
can-1683	446	2	.	.	PUNCT
can-1683	446	3	bejarano	bejarano	PROPN
can-1683	446	4	j	j	PROPN
can-1683	446	5	,	,	PUNCT
can-1683	446	6	navarro	navarro	PROPN
can-1683	446	7	-	-	PUNCT
can-1683	446	8	marquez	marquez	PROPN
can-1683	446	9	m	m	PROPN
can-1683	446	10	,	,	PUNCT
can-1683	446	11	morales	morale	NOUN
can-1683	446	12	-	-	PUNCT
can-1683	446	13	zavala	zavala	NOUN
can-1683	446	14	f	f	PROPN
can-1683	446	15	,	,	PUNCT
can-1683	446	16	et	et	PROPN
can-1683	446	17	al	al	PROPN
can-1683	446	18	.	.	PROPN
can-1683	446	19	nanoparticles	nanoparticle	NOUN
can-1683	446	20	for	for	ADP
can-1683	446	21	diagnosis	diagnosis	NOUN
can-1683	446	22	and	and	CCONJ
can-1683	446	23	therapy	therapy	NOUN
can-1683	446	24	of	of	ADP
can-1683	446	25	atherosclerosis	atherosclerosis	NOUN
can-1683	446	26	and	and	CCONJ
can-1683	446	27	myocardial	myocardial	ADJ
can-1683	446	28	infarction	infarction	NOUN
can-1683	446	29	:	:	PUNCT
can-1683	446	30	evolution	evolution	NOUN
can-1683	446	31	toward	toward	ADP
can-1683	446	32	prospective	prospective	ADJ
can-1683	446	33	theranostic	theranostic	ADJ
can-1683	446	34	approaches	approach	NOUN
can-1683	446	35	.	.	PUNCT
can-1683	447	1	theranostics	theranostic	NOUN
can-1683	447	2	2018	2018	NUM
can-1683	447	3	;	;	PUNCT
can-1683	447	4	8(17	8(17	NUM
can-1683	447	5	):	):	PUNCT
can-1683	447	6	4710–4732	4710–4732	NUM
can-1683	447	7	.	.	PUNCT
can-1683	448	1	doi	doi	NOUN
can-1683	448	2	:	:	PUNCT
can-1683	448	3	10.7150	10.7150	NUM
can-1683	448	4	/	/	SYM
can-1683	448	5	thno.26284	thno.26284	NOUN
can-1683	448	6	.	.	NOUN
can-1683	448	7	46	46	NUM
can-1683	448	8	.	.	PUNCT
can-1683	449	1	sharma	sharma	PROPN
can-1683	449	2	m	m	PROPN
can-1683	449	3	,	,	PUNCT
can-1683	449	4	sharma	sharma	PROPN
can-1683	449	5	r	r	PROPN
can-1683	449	6	,	,	PUNCT
can-1683	449	7	jain	jain	PROPN
can-1683	449	8	dk	dk	PROPN
can-1683	449	9	.	.	PROPN
can-1683	449	10	nanotechnology	nanotechnology	PROPN
can-1683	449	11	based	base	VERB
can-1683	449	12	approaches	approach	NOUN
can-1683	449	13	for	for	ADP
can-1683	449	14	enhancing	enhance	VERB
can-1683	449	15	oral	oral	ADJ
can-1683	449	16	bioavailability	bioavailability	NOUN
can-1683	449	17	of	of	ADP
can-1683	449	18	poorly	poorly	ADV
can-1683	449	19	water	water	NOUN
can-1683	449	20	soluble	soluble	ADJ
can-1683	449	21	antihypertensive	antihypertensive	ADJ
can-1683	449	22	drugs	drug	NOUN
can-1683	449	23	.	.	PUNCT
can-1683	450	1	scientifica	scientifica	PROPN
can-1683	450	2	2016	2016	NUM
can-1683	450	3	;	;	PUNCT
can-1683	450	4	2016	2016	NUM
can-1683	450	5	:	:	PUNCT
can-1683	450	6	8525679	8525679	NUM
can-1683	450	7	.	.	PUNCT
can-1683	451	1	doi	doi	NOUN
can-1683	451	2	:	:	PUNCT
can-1683	451	3	10.1155/2016/8525679	10.1155/2016/8525679	NUM
can-1683	451	4	.	.	PUNCT
can-1683	452	1	47	47	NUM
can-1683	452	2	.	.	PUNCT
can-1683	453	1	alam	alam	PROPN
can-1683	453	2	t	t	PROPN
can-1683	453	3	,	,	PUNCT
can-1683	453	4	khan	khan	PROPN
can-1683	453	5	s	s	PROPN
can-1683	453	6	,	,	PUNCT
can-1683	453	7	gaba	gaba	PROPN
can-1683	453	8	b	b	PROPN
can-1683	453	9	,	,	PUNCT
can-1683	453	10	et	et	PROPN
can-1683	453	11	al	al	PROPN
can-1683	453	12	.	.	PROPN
can-1683	453	13	nanocarriers	nanocarrier	NOUN
can-1683	453	14	as	as	ADP
can-1683	453	15	treatment	treatment	NOUN
can-1683	453	16	modalities	modality	NOUN
can-1683	453	17	for	for	ADP
can-1683	453	18	hypertension	hypertension	NOUN
can-1683	453	19	.	.	PUNCT
can-1683	454	1	drug	drug	NOUN
can-1683	454	2	delivery	delivery	PROPN
can-1683	454	3	2017	2017	NUM
can-1683	454	4	;	;	PUNCT
can-1683	454	5	24(1	24(1	NUM
can-1683	454	6	):	):	PUNCT
can-1683	454	7	358–369	358–369	NUM
can-1683	454	8	.	.	PUNCT
can-1683	455	1	doi	doi	NOUN
can-1683	455	2	:	:	PUNCT
can-1683	455	3	10.1080/10717544.2016.12	10.1080/10717544.2016.12	NUM
can-1683	455	4	55999	55999	NUM
can-1683	455	5	.	.	PUNCT
can-1683	456	1	48	48	NUM
can-1683	456	2	.	.	PUNCT
can-1683	457	1	ghasemian	ghasemian	PROPN
can-1683	457	2	e	e	PROPN
can-1683	457	3	,	,	PUNCT
can-1683	457	4	motaghian	motaghian	PROPN
can-1683	457	5	p	p	X
can-1683	457	6	,	,	PUNCT
can-1683	457	7	vatanara	vatanara	PROPN
can-1683	457	8	a.	a.	NOUN
can-1683	457	9	d	d	ADJ
can-1683	457	10	-	-	ADJ
can-1683	457	11	optimal	optimal	ADJ
can-1683	457	12	design	design	NOUN
can-1683	457	13	for	for	ADP
can-1683	457	14	preparation	preparation	NOUN
can-1683	457	15	and	and	CCONJ
can-1683	457	16	optimization	optimization	NOUN
can-1683	457	17	of	of	ADP
can-1683	457	18	fast	fast	ADJ
can-1683	457	19	dissolving	dissolve	VERB
can-1683	457	20	bosentan	bosentan	ADJ
can-1683	457	21	nanosuspension	nanosuspension	NOUN
can-1683	457	22	.	.	PUNCT
can-1683	458	1	advanced	advanced	ADJ
can-1683	458	2	pharmaceutical	pharmaceutical	ADJ
can-1683	458	3	bulletin	bulletin	NOUN
can-1683	458	4	2016	2016	NUM
can-1683	458	5	;	;	PUNCT
can-1683	458	6	6(2	6(2	NUM
can-1683	458	7	):	):	PUNCT
can-1683	458	8	211	211	NUM
can-1683	458	9	.	.	PUNCT
can-1683	459	1	doi	doi	NOUN
can-1683	459	2	:	:	PUNCT
can-1683	459	3	10.15171	10.15171	NUM
can-1683	459	4	/	/	SYM
can-1683	459	5	apb.2016.029	apb.2016.029	NOUN
can-1683	459	6	.	.	PUNCT
can-1683	460	1	49	49	NUM
can-1683	460	2	.	.	PUNCT
can-1683	461	1	hausenloy	hausenloy	NOUN
can-1683	461	2	dj	dj	PROPN
can-1683	461	3	,	,	PUNCT
can-1683	461	4	yellon	yellon	PROPN
can-1683	461	5	dm	dm	PROPN
can-1683	461	6	.	.	PROPN
can-1683	461	7	myocardial	myocardial	ADJ
can-1683	461	8	ischemia	ischemia	NOUN
can-1683	461	9	-	-	PUNCT
can-1683	461	10	reperfusion	reperfusion	NOUN
can-1683	461	11	injury	injury	NOUN
can-1683	461	12	:	:	PUNCT
can-1683	461	13	a	a	DET
can-1683	461	14	neglected	neglect	VERB
can-1683	461	15	therapeutic	therapeutic	ADJ
can-1683	461	16	target	target	NOUN
can-1683	461	17	.	.	PUNCT
can-1683	462	1	journal	journal	NOUN
can-1683	462	2	of	of	ADP
can-1683	462	3	clinical	clinical	ADJ
can-1683	462	4	investigation	investigation	NOUN
can-1683	462	5	2013	2013	NUM
can-1683	462	6	;	;	PUNCT
can-1683	462	7	123(1	123(1	NUM
can-1683	462	8	):	):	PUNCT
can-1683	462	9	92–100	92–100	NUM
can-1683	462	10	.	.	PUNCT
can-1683	463	1	doi	doi	NOUN
can-1683	463	2	:	:	PUNCT
can-1683	463	3	10.1172	10.1172	NUM
can-1683	463	4	/	/	SYM
can-1683	463	5	jci62874	jci62874	NOUN
can-1683	463	6	.	.	PUNCT
can-1683	464	1	50	50	NUM
can-1683	464	2	.	.	X
can-1683	465	1	barbieri	barbieri	PROPN
can-1683	465	2	lr	lr	PROPN
can-1683	465	3	,	,	PUNCT
can-1683	465	4	lourenço	lourenço	ADJ
can-1683	465	5	-	-	PUNCT
can-1683	465	6	filho	filho	NOUN
can-1683	465	7	dd	dd	NOUN
can-1683	465	8	,	,	PUNCT
can-1683	465	9	tavares	tavare	NOUN
can-1683	465	10	er	er	INTJ
can-1683	465	11	,	,	PUNCT
can-1683	465	12	et	et	PROPN
can-1683	465	13	al	al	PROPN
can-1683	465	14	.	.	PUNCT
can-1683	465	15	influence	influence	NOUN
can-1683	465	16	of	of	ADP
can-1683	465	17	drugs	drug	NOUN
can-1683	465	18	carried	carry	VERB
can-1683	465	19	in	in	ADP
can-1683	465	20	lipid	lipid	ADJ
can-1683	465	21	nanoparticles	nanoparticle	NOUN
can-1683	465	22	in	in	ADP
can-1683	465	23	coronary	coronary	ADJ
can-1683	465	24	disease	disease	NOUN
can-1683	465	25	of	of	ADP
can-1683	465	26	rabbit	rabbit	NOUN
can-1683	465	27	transplanted	transplant	VERB
can-1683	465	28	heart	heart	NOUN
can-1683	465	29	.	.	PUNCT
can-1683	466	1	annals	annal	NOUN
can-1683	466	2	of	of	ADP
can-1683	466	3	thoracic	thoracic	NOUN
can-1683	466	4	surgery	surgery	NOUN
can-1683	466	5	2017	2017	NUM
can-1683	466	6	;	;	PUNCT
can-1683	466	7	104(2	104(2	NUM
can-1683	466	8	):	):	PUNCT
can-1683	466	9	577–583	577–583	NUM
can-1683	466	10	.	.	PUNCT
can-1683	467	1	doi	doi	NOUN
can-1683	467	2	:	:	PUNCT
can-1683	467	3	10.1016	10.1016	NUM
can-1683	467	4	/	/	SYM
can-1683	467	5	j.athoracsur.2016.12.044	j.athoracsur.2016.12.044	PROPN
can-1683	467	6	.	.	PROPN
can-1683	468	1	51	51	NUM
can-1683	468	2	.	.	PUNCT
can-1683	469	1	zhou	zhou	PROPN
can-1683	469	2	x	x	PROPN
can-1683	469	3	,	,	PUNCT
can-1683	469	4	luo	luo	PROPN
can-1683	469	5	yc	yc	PROPN
can-1683	469	6	,	,	PUNCT
can-1683	469	7	ji	ji	PROPN
can-1683	469	8	wj	wj	PROPN
can-1683	469	9	,	,	PUNCT
can-1683	469	10	et	et	PROPN
can-1683	469	11	al	al	PROPN
can-1683	469	12	.	.	PROPN
can-1683	469	13	modulation	modulation	NOUN
can-1683	469	14	of	of	ADP
can-1683	469	15	mononuclear	mononuclear	ADJ
can-1683	469	16	phagocyte	phagocyte	NOUN
can-1683	469	17	inflammatory	inflammatory	ADJ
can-1683	469	18	response	response	NOUN
can-1683	469	19	by	by	ADP
can-1683	469	20	liposome	liposome	NOUN
can-1683	469	21	-	-	PUNCT
can-1683	469	22	encapsulated	encapsulate	VERB
can-1683	469	23	voltage	voltage	NOUN
can-1683	469	24	gated	gate	VERB
can-1683	469	25	sodium	sodium	NOUN
can-1683	469	26	channel	channel	NOUN
can-1683	469	27	inhibitor	inhibitor	NOUN
can-1683	469	28	ameliorates	ameliorate	VERB
can-1683	469	29	myocardial	myocardial	ADJ
can-1683	469	30	ischemia	ischemia	NOUN
can-1683	469	31	/	/	SYM
can-1683	469	32	reperfusion	reperfusion	NOUN
can-1683	469	33	injury	injury	NOUN
can-1683	469	34	in	in	ADP
can-1683	469	35	rats	rat	NOUN
can-1683	469	36	.	.	PUNCT
can-1683	470	1	plos	plos	PROPN
can-1683	470	2	one	one	NUM
can-1683	470	3	2013	2013	NUM
can-1683	470	4	;	;	PUNCT
can-1683	470	5	8(9	8(9	NUM
can-1683	470	6	):	):	PUNCT
can-1683	470	7	e0074390	e0074390	PROPN
can-1683	470	8	.	.	PUNCT
can-1683	471	1	doi	doi	NOUN
can-1683	471	2	:	:	PUNCT
can-1683	471	3	10.1371	10.1371	NUM
can-1683	471	4	/	/	SYM
can-1683	471	5	journal.pone.00	journal.pone.00	NOUN
can-1683	471	6	74390	74390	NUM
can-1683	471	7	.	.	PUNCT
can-1683	472	1	52	52	NUM
can-1683	472	2	.	.	PUNCT
can-1683	473	1	wu	wu	PROPN
can-1683	473	2	t	t	PROPN
can-1683	473	3	,	,	PUNCT
can-1683	473	4	ding	ding	NOUN
can-1683	473	5	m	m	PROPN
can-1683	473	6	,	,	PUNCT
can-1683	473	7	shi	shi	PROPN
can-1683	473	8	c	c	PROPN
can-1683	473	9	,	,	PUNCT
can-1683	473	10	et	et	PROPN
can-1683	473	11	al	al	PROPN
can-1683	473	12	.	.	PROPN
can-1683	473	13	resorbable	resorbable	ADJ
can-1683	473	14	polymer	polymer	NOUN
can-1683	473	15	electrospun	electrospun	NOUN
can-1683	473	16	nanofibers	nanofiber	NOUN
can-1683	473	17	:	:	PUNCT
can-1683	473	18	history	history	NOUN
can-1683	473	19	,	,	PUNCT
can-1683	473	20	shapes	shape	NOUN
can-1683	473	21	and	and	CCONJ
can-1683	473	22	application	application	NOUN
can-1683	473	23	for	for	ADP
can-1683	473	24	tissue	tissue	NOUN
can-1683	473	25	engineering	engineering	NOUN
can-1683	473	26	.	.	PUNCT
can-1683	474	1	chinese	chinese	ADJ
can-1683	474	2	chemical	chemical	NOUN
can-1683	474	3	letters	letter	NOUN
can-1683	474	4	2020	2020	NUM
can-1683	474	5	;	;	PUNCT
can-1683	474	6	31(3	31(3	NUM
can-1683	474	7	):	):	PUNCT
can-1683	474	8	617–625	617–625	NUM
can-1683	474	9	.	.	PUNCT
can-1683	475	1	doi	doi	NOUN
can-1683	475	2	:	:	PUNCT
can-1683	475	3	10.1016	10.1016	NUM
can-1683	475	4	/	/	SYM
can-1683	475	5	j.cclet.2019.07.033	j.cclet.2019.07.033	PROPN
can-1683	475	6	.	.	PROPN
can-1683	476	1	53	53	NUM
can-1683	476	2	.	.	PUNCT
can-1683	477	1	braukmann	braukmann	PROPN
can-1683	477	2	f	f	PROPN
can-1683	477	3	,	,	PUNCT
can-1683	477	4	jordan	jordan	PROPN
can-1683	477	5	d	d	PROPN
can-1683	477	6	,	,	PUNCT
can-1683	477	7	miska	miska	PROPN
can-1683	477	8	e.	e.	PROPN
can-1683	477	9	artificial	artificial	PROPN
can-1683	477	10	and	and	CCONJ
can-1683	477	11	natural	natural	ADJ
can-1683	477	12	rna	rna	NOUN
can-1683	477	13	interactions	interaction	NOUN
can-1683	477	14	between	between	ADP
can-1683	477	15	bacteria	bacteria	NOUN
can-1683	477	16	and	and	CCONJ
can-1683	477	17	c.	c.	PROPN
can-1683	477	18	elegans	elegans	PROPN
can-1683	477	19	.	.	PUNCT
can-1683	478	1	rna	rna	NOUN
can-1683	478	2	biology	biology	NOUN
can-1683	478	3	2017	2017	NUM
can-1683	478	4	;	;	PUNCT
can-1683	478	5	14(4	14(4	NUM
can-1683	478	6	):	):	PUNCT
can-1683	478	7	415–420	415–420	NUM
can-1683	478	8	.	.	PUNCT
can-1683	479	1	doi	doi	NOUN
can-1683	479	2	:	:	PUNCT
can-1683	479	3	10.1080/15476286.2017.1297912	10.1080/15476286.2017.1297912	NUM
can-1683	479	4	.	.	PUNCT
can-1683	480	1	54	54	NUM
can-1683	480	2	.	.	PUNCT
can-1683	480	3	katyayani	katyayani	PROPN
can-1683	480	4	t	t	PROPN
can-1683	480	5	,	,	PUNCT
can-1683	480	6	samaresh	samaresh	PROPN
can-1683	480	7	s	s	PROPN
can-1683	480	8	,	,	PUNCT
can-1683	480	9	sushil	sushil	PROPN
can-1683	480	10	k	k	PROPN
can-1683	480	11	,	,	PUNCT
can-1683	480	12	et	et	PROPN
can-1683	480	13	al	al	PROPN
can-1683	480	14	.	.	PUNCT
can-1683	481	1	sirna	sirna	PROPN
can-1683	481	2	delivery	delivery	NOUN
can-1683	481	3	strategies	strategy	NOUN
can-1683	481	4	:	:	PUNCT
can-1683	481	5	a	a	DET
can-1683	481	6	comprehensive	comprehensive	ADJ
can-1683	481	7	review	review	NOUN
can-1683	481	8	of	of	ADP
can-1683	481	9	recent	recent	ADJ
can-1683	481	10	developments	development	NOUN
can-1683	481	11	.	.	PUNCT
can-1683	482	1	nanomaterials	nanomaterial	NOUN
can-1683	482	2	2017	2017	NUM
can-1683	482	3	;	;	PUNCT
can-1683	482	4	7(4	7(4	NUM
can-1683	482	5	):	):	PUNCT
can-1683	482	6	77	77	NUM
can-1683	482	7	.	.	PUNCT
can-1683	483	1	doi	doi	NOUN
can-1683	483	2	:	:	PUNCT
can-1683	483	3	10.3390	10.3390	NUM
can-1683	483	4	/	/	SYM
can-1683	483	5	nano7040077	nano7040077	PROPN
can-1683	483	6	.	.	PUNCT
can-1683	484	1	55	55	NUM
can-1683	484	2	.	.	PUNCT
can-1683	485	1	cotten	cotten	PROPN
can-1683	485	2	m	m	PROPN
can-1683	485	3	,	,	PUNCT
can-1683	485	4	wagner	wagner	PROPN
can-1683	485	5	e	e	PROPN
can-1683	485	6	,	,	PUNCT
can-1683	485	7	zatloukal	zatloukal	PROPN
can-1683	485	8	k	k	PROPN
can-1683	485	9	,	,	PUNCT
can-1683	485	10	et	et	PROPN
can-1683	485	11	al	al	PROPN
can-1683	485	12	.	.	PROPN
can-1683	485	13	high	high	ADJ
can-1683	485	14	-	-	PUNCT
can-1683	485	15	efficiency	efficiency	NOUN
can-1683	485	16	receptor	receptor	NOUN
can-1683	485	17	-	-	PUNCT
can-1683	485	18	mediated	mediate	VERB
can-1683	485	19	delivery	delivery	NOUN
can-1683	485	20	of	of	ADP
can-1683	485	21	small	small	ADJ
can-1683	485	22	and	and	CCONJ
can-1683	485	23	large	large	ADJ
can-1683	485	24	(	(	PUNCT
can-1683	485	25	48	48	NUM
can-1683	485	26	kilobase	kilobase	NOUN
can-1683	485	27	gene	gene	NOUN
can-1683	485	28	constructs	construct	NOUN
can-1683	485	29	using	use	VERB
can-1683	485	30	the	the	DET
can-1683	485	31	endosome	endosome	NOUN
can-1683	485	32	-	-	PUNCT
can-1683	485	33	disruption	disruption	NOUN
can-1683	485	34	activity	activity	NOUN
can-1683	485	35	of	of	ADP
can-1683	485	36	defective	defective	ADJ
can-1683	485	37	or	or	CCONJ
can-1683	485	38	chemically	chemically	ADV
can-1683	485	39	inactivated	inactivate	VERB
can-1683	485	40	adenovirus	adenovirus	NOUN
can-1683	485	41	particles	particle	NOUN
can-1683	485	42	.	.	PUNCT
can-1683	486	1	proceedings	proceeding	NOUN
can-1683	486	2	of	of	ADP
can-1683	486	3	the	the	DET
can-1683	486	4	national	national	PROPN
can-1683	486	5	academy	academy	PROPN
can-1683	486	6	of	of	ADP
can-1683	486	7	sciences	sciences	PROPN
can-1683	486	8	of	of	ADP
can-1683	486	9	the	the	DET
can-1683	486	10	united	united	PROPN
can-1683	486	11	states	states	PROPN
can-1683	486	12	of	of	ADP
can-1683	486	13	america	america	PROPN
can-1683	486	14	1992	1992	NUM
can-1683	486	15	;	;	PUNCT
can-1683	486	16	89(13	89(13	NUM
can-1683	486	17	):	):	PUNCT
can-1683	486	18	6094–6098	6094–6098	NOUN
can-1683	486	19	.	.	PUNCT
can-1683	487	1	doi	doi	NOUN
can-1683	487	2	:	:	PUNCT
can-1683	487	3	10.1073	10.1073	NUM
can-1683	487	4	/	/	SYM
can-1683	487	5	pnas.89.13.6094	pnas.89.13.6094	NOUN
can-1683	487	6	.	.	PUNCT
can-1683	488	1	56	56	NUM
can-1683	488	2	.	.	PUNCT
can-1683	489	1	zimmermann	zimmermann	PROPN
can-1683	489	2	ts	ts	PROPN
can-1683	489	3	,	,	PUNCT
can-1683	489	4	lee	lee	PROPN
can-1683	489	5	ach	ach	PROPN
can-1683	489	6	,	,	PUNCT
can-1683	489	7	akinc	akinc	PROPN
can-1683	489	8	a	a	PROPN
can-1683	489	9	,	,	PUNCT
can-1683	489	10	et	et	PROPN
can-1683	489	11	al	al	PROPN
can-1683	489	12	.	.	PROPN
can-1683	489	13	rnai	rnai	PROPN
can-1683	489	14	-	-	PUNCT
can-1683	489	15	mediated	mediate	VERB
can-1683	489	16	gene	gene	NOUN
can-1683	489	17	silencing	silence	VERB
can-1683	489	18	in	in	ADP
can-1683	489	19	non	non	ADJ
can-1683	489	20	-	-	ADJ
can-1683	489	21	human	human	ADJ
can-1683	489	22	primates	primate	NOUN
can-1683	489	23	.	.	PUNCT
can-1683	490	1	nature	nature	NOUN
can-1683	490	2	2006	2006	NUM
can-1683	490	3	;	;	PUNCT
can-1683	490	4	441(7089	441(7089	NUM
can-1683	490	5	):	):	PUNCT
can-1683	490	6	111–114	111–114	NUM
can-1683	490	7	.	.	PUNCT
can-1683	491	1	doi	doi	NOUN
can-1683	491	2	:	:	PUNCT
can-1683	491	3	10.1038	10.1038	NUM
can-1683	491	4	/	/	SYM
can-1683	491	5	nature04688	nature04688	PROPN
can-1683	491	6	.	.	PUNCT
can-1683	492	1	57	57	NUM
can-1683	492	2	.	.	PUNCT
can-1683	493	1	somasuntharam	somasuntharam	PROPN
can-1683	494	1	i	i	PRON
can-1683	494	2	,	,	PUNCT
can-1683	494	3	boopathy	boopathy	PROPN
can-1683	494	4	av	av	PROPN
can-1683	494	5	,	,	PUNCT
can-1683	494	6	khan	khan	PROPN
can-1683	494	7	rs	rs	PROPN
can-1683	494	8	,	,	PUNCT
can-1683	494	9	et	et	PROPN
can-1683	494	10	al	al	PROPN
can-1683	494	11	.	.	PUNCT
can-1683	494	12	delivery	delivery	NOUN
can-1683	494	13	of	of	ADP
can-1683	494	14	nox2	nox2	PROPN
can-1683	494	15	-	-	PUNCT
can-1683	494	16	nadph	nadph	ADJ
can-1683	494	17	oxidase	oxidase	NOUN
can-1683	494	18	sirna	sirna	PROPN
can-1683	494	19	with	with	ADP
can-1683	494	20	polyketal	polyketal	ADJ
can-1683	494	21	nanoparticles	nanoparticle	NOUN
can-1683	494	22	for	for	ADP
can-1683	494	23	improving	improve	VERB
can-1683	494	24	cardiac	cardiac	ADJ
can-1683	494	25	function	function	NOUN
can-1683	494	26	following	follow	VERB
can-1683	494	27	myocardial	myocardial	ADJ
can-1683	494	28	infarction	infarction	NOUN
can-1683	494	29	.	.	PUNCT
can-1683	495	1	biomaterials	biomaterial	NOUN
can-1683	495	2	2013	2013	NUM
can-1683	495	3	;	;	PUNCT
can-1683	495	4	34(31	34(31	NUM
can-1683	495	5	):	):	PUNCT
can-1683	495	6	7790–7798	7790–7798	NOUN
can-1683	495	7	.	.	PUNCT
can-1683	496	1	doi	doi	NOUN
can-1683	496	2	:	:	PUNCT
can-1683	496	3	10.1016	10.1016	NUM
can-1683	496	4	/	/	SYM
can-1683	496	5	j.biomaterials.2013.06.051	j.biomaterials.2013.06.051	PROPN
can-1683	496	6	.	.	PROPN
can-1683	497	1	58	58	NUM
can-1683	497	2	.	.	PUNCT
can-1683	498	1	fitzgerald	fitzgerald	PROPN
can-1683	498	2	k	k	PROPN
can-1683	498	3	,	,	PUNCT
can-1683	498	4	frank	frank	ADJ
can-1683	498	5	-	-	PUNCT
can-1683	498	6	kamenetsky	kamenetsky	PROPN
can-1683	498	7	m	m	PROPN
can-1683	498	8	,	,	PUNCT
can-1683	498	9	shulga	shulga	PROPN
can-1683	498	10	-	-	PUNCT
can-1683	498	11	morskaya	morskaya	PROPN
can-1683	498	12	s	s	PROPN
can-1683	498	13	,	,	PUNCT
can-1683	498	14	et	et	PROPN
can-1683	498	15	al	al	PROPN
can-1683	498	16	.	.	PROPN
can-1683	499	1	effect	effect	NOUN
can-1683	499	2	of	of	ADP
can-1683	499	3	an	an	DET
can-1683	499	4	rna	rna	NOUN
can-1683	499	5	interference	interference	NOUN
can-1683	499	6	drug	drug	NOUN
can-1683	499	7	on	on	ADP
can-1683	499	8	the	the	DET
can-1683	499	9	synthesis	synthesis	NOUN
can-1683	499	10	of	of	ADP
can-1683	499	11	proprotein	proprotein	PROPN
can-1683	499	12	convertase	convertase	PROPN
can-1683	499	13	subtilisin	subtilisin	PROPN
can-1683	499	14	/	/	SYM
can-1683	499	15	kexin	kexin	NOUN
can-1683	499	16	type	type	NOUN
can-1683	499	17	9	9	NUM
can-1683	499	18	(	(	PUNCT
can-1683	499	19	pcsk9	pcsk9	NOUN
can-1683	499	20	)	)	PUNCT
can-1683	499	21	and	and	CCONJ
can-1683	499	22	the	the	DET
can-1683	499	23	concentration	concentration	NOUN
can-1683	499	24	of	of	ADP
can-1683	499	25	serum	serum	NOUN
can-1683	499	26	ldl	ldl	NOUN
can-1683	499	27	cholesterol	cholesterol	NOUN
can-1683	499	28	in	in	ADP
can-1683	499	29	healthy	healthy	ADJ
can-1683	499	30	volunteers	volunteer	NOUN
can-1683	499	31	:	:	PUNCT
can-1683	499	32	a	a	DET
can-1683	499	33	randomised	randomised	ADJ
can-1683	499	34	,	,	PUNCT
can-1683	499	35	single	single	ADJ
can-1683	499	36	-	-	PUNCT
can-1683	499	37	blind	blind	ADJ
can-1683	499	38	,	,	PUNCT
can-1683	499	39	placebo	placebo	NOUN
can-1683	499	40	-	-	PUNCT
can-1683	499	41	controlled	control	VERB
can-1683	499	42	,	,	PUNCT
can-1683	499	43	phase	phase	NOUN
can-1683	499	44	1	1	NUM
can-1683	499	45	trial	trial	NOUN
can-1683	499	46	.	.	PUNCT
can-1683	500	1	lancet	lancet	PROPN
can-1683	500	2	2014	2014	NUM
can-1683	500	3	;	;	PUNCT
can-1683	501	1	383(9911	383(9911	NUM
can-1683	501	2	):	):	PUNCT
can-1683	501	3	60–68	60–68	PROPN
can-1683	501	4	.	.	PUNCT
can-1683	501	5	doi	doi	PROPN
can-1683	501	6	:	:	PUNCT
can-1683	501	7	10.1016	10.1016	NUM
can-1683	501	8	/	/	SYM
can-1683	501	9	s0140	s0140	PROPN
can-1683	501	10	-	-	PUNCT
can-1683	501	11	6736(13)61914	6736(13)61914	NUM
can-1683	501	12	-	-	PUNCT
can-1683	501	13	5	5	NUM
can-1683	501	14	.	.	NOUN
can-1683	501	15	59	59	NUM
can-1683	501	16	.	.	PUNCT
can-1683	501	17	gatoo	gatoo	PROPN
can-1683	501	18	ma	ma	PROPN
can-1683	501	19	,	,	PUNCT
can-1683	501	20	naseem	naseem	PROPN
can-1683	501	21	s	s	PROPN
can-1683	501	22	,	,	PUNCT
can-1683	501	23	arfat	arfat	VERB
can-1683	501	24	my	my	PRON
can-1683	501	25	,	,	PUNCT
can-1683	501	26	et	et	PROPN
can-1683	501	27	al	al	PROPN
can-1683	501	28	.	.	PUNCT
can-1683	501	29	physicochemical	physicochemical	ADJ
can-1683	501	30	properties	property	NOUN
can-1683	501	31	of	of	ADP
can-1683	501	32	nanomaterials	nanomaterial	NOUN
can-1683	501	33	:	:	PUNCT
can-1683	501	34	implication	implication	NOUN
can-1683	501	35	in	in	ADP
can-1683	501	36	associated	associated	ADJ
can-1683	501	37	toxic	toxic	ADJ
can-1683	501	38	manifestations	manifestation	NOUN
can-1683	501	39	.	.	PUNCT
can-1683	502	1	biomed	biome	VERB
can-1683	502	2	research	research	NOUN
can-1683	502	3	international	international	ADJ
can-1683	502	4	2014	2014	NUM
can-1683	502	5	;	;	PUNCT
can-1683	502	6	2014	2014	NUM
can-1683	502	7	:	:	PUNCT
can-1683	502	8	498420	498420	NUM
can-1683	502	9	.	.	PUNCT
can-1683	503	1	doi	doi	NOUN
can-1683	503	2	:	:	PUNCT
can-1683	503	3	10.1155/2014/498420	10.1155/2014/498420	NUM
can-1683	503	4	.	.	NOUN
can-1683	503	5	60	60	NUM
can-1683	503	6	.	.	PUNCT
can-1683	504	1	donnini	donnini	PROPN
can-1683	504	2	d	d	NOUN
can-1683	504	3	,	,	PUNCT
can-1683	504	4	perrella	perrella	NOUN
can-1683	504	5	g	g	NOUN
can-1683	504	6	,	,	PUNCT
can-1683	504	7	stel	stel	NOUN
can-1683	504	8	g	g	PROPN
can-1683	504	9	,	,	PUNCT
can-1683	504	10	et	et	PROPN
can-1683	504	11	al	al	PROPN
can-1683	504	12	.	.	PUNCT
can-1683	505	1	a	a	DET
can-1683	505	2	new	new	ADJ
can-1683	505	3	model	model	NOUN
can-1683	505	4	of	of	ADP
can-1683	505	5	human	human	ADJ
can-1683	505	6	aortic	aortic	ADJ
can-1683	505	7	endothelial	endothelial	NOUN
can-1683	505	8	cells	cell	NOUN
can-1683	505	9	in	in	ADP
can-1683	505	10	vitro	vitro	X
can-1683	505	11	.	.	PUNCT
can-1683	506	1	biochimie	biochimie	ADP
can-1683	506	2	2000	2000	NUM
can-1683	506	3	;	;	PUNCT
can-1683	506	4	82(12	82(12	NUM
can-1683	506	5	):	):	PUNCT
can-1683	506	6	1107–1114	1107–1114	NUM
can-1683	506	7	.	.	PUNCT
can-1683	507	1	doi	doi	NOUN
can-1683	507	2	:	:	PUNCT
can-1683	507	3	10.1016	10.1016	NUM
can-1683	507	4	/	/	SYM
can-1683	507	5	s0300	s0300	PROPN
can-1683	507	6	-	-	PUNCT
can-1683	507	7	9084(00)01195	9084(00)01195	NUM
can-1683	507	8	-	-	PUNCT
can-1683	507	9	0	0	NUM
can-1683	507	10	.	.	NOUN
can-1683	507	11	61	61	NUM
can-1683	507	12	.	.	PUNCT
can-1683	508	1	suwa	suwa	PROPN
can-1683	508	2	t	t	PROPN
can-1683	508	3	,	,	PUNCT
can-1683	508	4	hogg	hogg	PROPN
can-1683	508	5	jc	jc	PROPN
can-1683	508	6	,	,	PUNCT
can-1683	508	7	quinlan	quinlan	PROPN
can-1683	508	8	kb	kb	PROPN
can-1683	508	9	,	,	PUNCT
can-1683	508	10	et	et	PROPN
can-1683	508	11	al	al	PROPN
can-1683	508	12	.	.	PUNCT
can-1683	508	13	particulate	particulate	NOUN
can-1683	508	14	air	air	NOUN
can-1683	508	15	pollution	pollution	NOUN
can-1683	508	16	induces	induce	VERB
can-1683	508	17	progression	progression	NOUN
can-1683	508	18	of	of	ADP
can-1683	508	19	atherosclerosis	atherosclerosis	NOUN
can-1683	508	20	.	.	PUNCT
can-1683	509	1	journal	journal	NOUN
can-1683	509	2	of	of	ADP
can-1683	509	3	the	the	DET
can-1683	509	4	american	american	PROPN
can-1683	509	5	college	college	PROPN
can-1683	509	6	of	of	ADP
can-1683	509	7	cardiology	cardiology	NOUN
can-1683	509	8	2002	2002	NUM
can-1683	509	9	;	;	PUNCT
can-1683	509	10	39(6	39(6	NUM
can-1683	509	11	):	):	PUNCT
can-1683	509	12	935–942	935–942	NUM
can-1683	509	13	.	.	PUNCT
can-1683	510	1	doi	doi	NOUN
can-1683	510	2	:	:	PUNCT
can-1683	510	3	10.1016	10.1016	NUM
can-1683	510	4	/	/	SYM
can-1683	510	5	s0735	s0735	NUM
can-1683	510	6	-	-	PUNCT
can-1683	510	7	1097(02)01715	1097(02)01715	NUM
can-1683	510	8	-	-	SYM
can-1683	510	9	1	1	NUM
can-1683	510	10	.	.	NUM
can-1683	510	11	62	62	NUM
can-1683	510	12	.	.	PUNCT
can-1683	511	1	chen	chen	PROPN
can-1683	511	2	m	m	PROPN
can-1683	511	3	,	,	PUNCT
can-1683	511	4	von	von	PROPN
can-1683	511	5	ma	ma	PROPN
can-1683	511	6	.	.	PROPN
can-1683	511	7	formation	formation	NOUN
can-1683	511	8	of	of	ADP
can-1683	511	9	nucleoplasmic	nucleoplasmic	ADJ
can-1683	511	10	protein	protein	NOUN
can-1683	511	11	aggregates	aggregate	NOUN
can-1683	511	12	impairs	impair	VERB
can-1683	511	13	nuclear	nuclear	ADJ
can-1683	511	14	function	function	NOUN
can-1683	511	15	in	in	ADP
can-1683	511	16	response	response	NOUN
can-1683	511	17	to	to	ADP
can-1683	511	18	sio2	sio2	VERB
can-1683	511	19	nanoparticles	nanoparticle	NOUN
can-1683	511	20	.	.	PUNCT
can-1683	512	1	experimental	experimental	ADJ
can-1683	512	2	cell	cell	NOUN
can-1683	512	3	research	research	NOUN
can-1683	512	4	2005	2005	NUM
can-1683	512	5	;	;	PUNCT
can-1683	512	6	305(1	305(1	NUM
can-1683	512	7	):	):	PUNCT
can-1683	512	8	51–62	51–62	NUM
can-1683	512	9	.	.	PUNCT
can-1683	513	1	doi	doi	NOUN
can-1683	513	2	:	:	PUNCT
can-1683	513	3	10.1016	10.1016	NUM
can-1683	513	4	/	/	SYM
can-1683	513	5	j.yexcr.2004.12.021	j.yexcr.2004.12.021	NOUN
can-1683	513	6	.	.	PROPN
can-1683	514	1	63	63	NUM
can-1683	514	2	.	.	PUNCT
can-1683	514	3	han	han	PROPN
can-1683	514	4	w	w	PROPN
can-1683	514	5	,	,	PUNCT
can-1683	514	6	li	li	PROPN
can-1683	514	7	h	h	PROPN
can-1683	514	8	,	,	PUNCT
can-1683	514	9	yu	yu	PROPN
can-1683	514	10	x	x	PROPN
can-1683	514	11	,	,	PUNCT
can-1683	514	12	et	et	PROPN
can-1683	514	13	al	al	PROPN
can-1683	514	14	.	.	PROPN
can-1683	515	1	in	in	ADP
can-1683	515	2	vivo	vivo	ADJ
can-1683	515	3	toxicity	toxicity	NOUN
can-1683	515	4	evaluation	evaluation	NOUN
can-1683	515	5	of	of	ADP
can-1683	515	6	a	a	DET
can-1683	515	7	nano	nano	NOUN
can-1683	515	8	-	-	PUNCT
can-1683	515	9	drug	drug	NOUN
can-1683	515	10	delivery	delivery	NOUN
can-1683	515	11	system	system	NOUN
can-1683	515	12	using	use	VERB
can-1683	515	13	a	a	DET
can-1683	515	14	caenorhabditis	caenorhabditis	ADJ
can-1683	515	15	elegans	elegan	NOUN
can-1683	515	16	model	model	NOUN
can-1683	515	17	system	system	NOUN
can-1683	515	18	.	.	PUNCT
can-1683	516	1	chemical	chemical	ADJ
can-1683	516	2	research	research	NOUN
can-1683	516	3	in	in	ADP
can-1683	516	4	chinese	chinese	ADJ
can-1683	516	5	universities	university	NOUN
can-1683	516	6	2021	2021	NUM
can-1683	516	7	;	;	PUNCT
can-1683	516	8	38	38	NUM
can-1683	516	9	:	:	SYM
can-1683	516	10	1018–1024	1018–1024	NUM
can-1683	516	11	.	.	PUNCT
can-1683	517	1	64	64	NUM
can-1683	517	2	.	.	PUNCT
can-1683	517	3	tedla	tedla	NOUN
can-1683	517	4	n	n	CCONJ
can-1683	517	5	,	,	PUNCT
can-1683	517	6	jose	jose	PROPN
can-1683	517	7	r	r	PROPN
can-1683	517	8	,	,	PUNCT
can-1683	517	9	vicky	vicky	PROPN
can-1683	517	10	m	m	PROPN
can-1683	517	11	,	,	PUNCT
can-1683	517	12	et	et	PROPN
can-1683	517	13	al	al	PROPN
can-1683	517	14	.	.	PUNCT
can-1683	517	15	synthesis	synthesis	PROPN
can-1683	517	16	,	,	PUNCT
can-1683	517	17	pharmacokinetics	pharmacokinetic	NOUN
can-1683	517	18	,	,	PUNCT
can-1683	517	19	and	and	CCONJ
can-1683	517	20	toxicity	toxicity	NOUN
can-1683	517	21	of	of	ADP
can-1683	517	22	nano	nano	NOUN
can-1683	517	23	-	-	PUNCT
can-1683	517	24	drug	drug	NOUN
can-1683	517	25	carriers	carrier	NOUN
can-1683	517	26	.	.	PUNCT
can-1683	518	1	in	in	ADP
can-1683	518	2	:	:	PUNCT
can-1683	518	3	nanocarriers	nanocarrier	NOUN
can-1683	518	4	:	:	PUNCT
can-1683	518	5	drug	drug	NOUN
can-1683	518	6	delivery	delivery	NOUN
can-1683	518	7	system	system	NOUN
can-1683	518	8	.	.	PUNCT
can-1683	519	1	singapore	singapore	PROPN
can-1683	519	2	:	:	PUNCT
can-1683	519	3	springer	springer	NOUN
can-1683	519	4	;	;	PUNCT
can-1683	519	5	2021	2021	NUM
can-1683	519	6	.	.	PUNCT
can-1683	520	1	p.	p.	NOUN
can-1683	520	2	63–106	63–106	NUM
can-1683	520	3	.	.	PUNCT
can-1683	521	1	65	65	NUM
can-1683	521	2	.	.	PUNCT
can-1683	522	1	patnaik	patnaik	PROPN
can-1683	522	2	s	s	PROPN
can-1683	522	3	,	,	PUNCT
can-1683	522	4	gorain	gorain	NOUN
can-1683	522	5	b	b	NOUN
can-1683	522	6	,	,	PUNCT
can-1683	522	7	padhi	padhi	VERB
can-1683	522	8	s	s	PROPN
can-1683	522	9	,	,	PUNCT
can-1683	522	10	et	et	PROPN
can-1683	522	11	al	al	PROPN
can-1683	522	12	.	.	PUNCT
can-1683	523	1	recent	recent	ADJ
can-1683	523	2	update	update	NOUN
can-1683	523	3	of	of	ADP
can-1683	523	4	toxicity	toxicity	NOUN
can-1683	523	5	aspects	aspect	NOUN
can-1683	523	6	of	of	ADP
can-1683	523	7	nanoparticulate	nanoparticulate	ADJ
can-1683	523	8	systems	system	NOUN
can-1683	523	9	for	for	ADP
can-1683	523	10	drug	drug	NOUN
can-1683	523	11	delivery	delivery	NOUN
can-1683	523	12	.	.	PUNCT
can-1683	524	1	european	european	ADJ
can-1683	524	2	journal	journal	PROPN
can-1683	524	3	of	of	ADP
can-1683	524	4	pharmaceutics	pharmaceutic	NOUN
can-1683	524	5	and	and	CCONJ
can-1683	524	6	23	23	NUM
can-1683	524	7	biopharmaceutics	biopharmaceutic	NOUN
can-1683	524	8	2021	2021	NUM
can-1683	524	9	;	;	PUNCT
can-1683	524	10	161	161	NUM
can-1683	524	11	:	:	PUNCT
can-1683	524	12	100–119	100–119	NUM
can-1683	524	13	.	.	PUNCT