id	sid	tid	token	lemma	pos
can-1768	1	1	characterization	characterization	NOUN
can-1768	1	2	and	and	CCONJ
can-1768	1	3	application	application	NOUN
can-1768	1	4	of	of	ADP
can-1768	1	5	nanomaterials	nanomaterial	NOUN
can-1768	1	6	(	(	PUNCT
can-1768	1	7	2022	2022	NUM
can-1768	1	8	)	)	PUNCT
can-1768	1	9	volume	volume	NOUN
can-1768	1	10	5	5	NUM
can-1768	1	11	issue	issue	NOUN
can-1768	1	12	2	2	NUM
can-1768	1	13	doi:10.24294	doi:10.24294	NOUN
can-1768	1	14	/	/	SYM
can-1768	1	15	can.v5i2.1768	can.v5i2.1768	PROPN
can-1768	1	16	99	99	NUM
can-1768	1	17	original	original	ADJ
can-1768	1	18	research	research	NOUN
can-1768	1	19	article	article	NOUN
can-1768	1	20	development	development	NOUN
can-1768	1	21	,	,	PUNCT
can-1768	1	22	optimization	optimization	NOUN
can-1768	1	23	,	,	PUNCT
can-1768	1	24	and	and	CCONJ
can-1768	1	25	evaluation	evaluation	NOUN
can-1768	1	26	of	of	ADP
can-1768	1	27	cisplatin	cisplatin	NOUN
can-1768	1	28	-	-	PUNCT
can-1768	1	29	loaded	load	VERB
can-1768	1	30	plga	plga	NOUN
can-1768	1	31	nanoparticles	nanoparticle	NOUN
can-1768	1	32	purushothaman	purushothaman	NOUN
can-1768	1	33	bhuvaneshwaran	bhuvaneshwaran	VERB
can-1768	1	34	,	,	PUNCT
can-1768	1	35	ramaiyan	ramaiyan	ADJ
can-1768	1	36	velmurugan	velmurugan	NOUN
can-1768	1	37	*	*	PUNCT
can-1768	1	38	faculty	faculty	NOUN
can-1768	1	39	of	of	ADP
can-1768	1	40	pharmaceutical	pharmaceutical	ADJ
can-1768	1	41	sciences	science	NOUN
can-1768	1	42	,	,	PUNCT
can-1768	1	43	saveetha	saveetha	PROPN
can-1768	1	44	institute	institute	PROPN
can-1768	1	45	of	of	ADP
can-1768	1	46	medical	medical	ADJ
can-1768	1	47	and	and	CCONJ
can-1768	1	48	technical	technical	ADJ
can-1768	1	49	sciences	science	NOUN
can-1768	1	50	,	,	PUNCT
can-1768	1	51	chennai	chennai	PROPN
can-1768	1	52	,	,	PUNCT
can-1768	1	53	tamil	tamil	PROPN
can-1768	1	54	nadu	nadu	PROPN
can-1768	1	55	602105	602105	NUM
can-1768	1	56	,	,	PUNCT
can-1768	1	57	india	india	PROPN
can-1768	1	58	.	.	PUNCT
can-1768	2	1	e	e	X
can-1768	2	2	-	-	NOUN
can-1768	2	3	mail	mail	NOUN
can-1768	2	4	:	:	PUNCT
can-1768	2	5	ramaiyan.dr@gmail.com	ramaiyan.dr@gmail.com	PROPN
can-1768	2	6	abstract	abstract	ADJ
can-1768	2	7	nanoparticle	nanoparticle	NOUN
can-1768	2	8	drug	drug	NOUN
can-1768	2	9	delivery	delivery	NOUN
can-1768	2	10	systems	system	NOUN
can-1768	2	11	are	be	AUX
can-1768	2	12	engineered	engineer	VERB
can-1768	2	13	technologies	technology	NOUN
can-1768	2	14	that	that	PRON
can-1768	2	15	use	use	VERB
can-1768	2	16	nanoparticles	nanoparticle	NOUN
can-1768	2	17	for	for	ADP
can-1768	2	18	the	the	DET
can-1768	2	19	targeted	target	VERB
can-1768	2	20	delivery	delivery	NOUN
can-1768	2	21	and	and	CCONJ
can-1768	2	22	controlled	control	VERB
can-1768	2	23	release	release	NOUN
can-1768	2	24	of	of	ADP
can-1768	2	25	therapeutic	therapeutic	ADJ
can-1768	2	26	agents	agent	NOUN
can-1768	2	27	.	.	PUNCT
can-1768	3	1	cisplatin	cisplatin	NOUN
can-1768	3	2	-	-	PUNCT
can-1768	3	3	loaded	load	VERB
can-1768	3	4	nanoparticle	nanoparticle	NOUN
can-1768	3	5	formulations	formulation	NOUN
can-1768	3	6	were	be	AUX
can-1768	3	7	optimized	optimize	VERB
can-1768	3	8	utilizing	utilize	VERB
can-1768	3	9	response	response	NOUN
can-1768	3	10	surface	surface	NOUN
can-1768	3	11	methods	method	NOUN
can-1768	3	12	and	and	CCONJ
can-1768	3	13	the	the	DET
can-1768	3	14	central	central	ADJ
can-1768	3	15	composite	composite	ADJ
can-1768	3	16	rotating	rotating	NOUN
can-1768	3	17	design	design	NOUN
can-1768	3	18	model	model	NOUN
can-1768	3	19	.	.	PUNCT
can-1768	4	1	this	this	DET
can-1768	4	2	study	study	NOUN
can-1768	4	3	employed	employ	VERB
can-1768	4	4	a	a	DET
can-1768	4	5	central	central	ADJ
can-1768	4	6	composite	composite	ADJ
can-1768	4	7	rotatable	rotatable	ADJ
can-1768	4	8	design	design	NOUN
can-1768	4	9	with	with	ADP
can-1768	4	10	a	a	DET
can-1768	4	11	three	three	NUM
can-1768	4	12	-	-	PUNCT
can-1768	4	13	factored	factor	VERB
can-1768	4	14	factorial	factorial	NOUN
can-1768	4	15	design	design	NOUN
can-1768	4	16	with	with	ADP
can-1768	4	17	three	three	NUM
can-1768	4	18	tiers	tier	NOUN
can-1768	4	19	.	.	PUNCT
can-1768	5	1	three	three	NUM
can-1768	5	2	independent	independent	ADJ
can-1768	5	3	variables	variable	NOUN
can-1768	5	4	namely	namely	ADV
can-1768	5	5	drug	drug	NOUN
can-1768	5	6	polymer	polymer	NOUN
can-1768	5	7	ratio	ratio	NOUN
can-1768	5	8	,	,	PUNCT
can-1768	5	9	aqueous	aqueous	ADJ
can-1768	5	10	organic	organic	ADJ
can-1768	5	11	phase	phase	NOUN
can-1768	5	12	ration	ration	NOUN
can-1768	5	13	,	,	PUNCT
can-1768	5	14	and	and	CCONJ
can-1768	5	15	stabilizer	stabilizer	NOUN
can-1768	5	16	concentration	concentration	NOUN
can-1768	5	17	were	be	AUX
can-1768	5	18	used	use	VERB
can-1768	5	19	to	to	PART
can-1768	5	20	examine	examine	VERB
can-1768	5	21	the	the	DET
can-1768	5	22	particle	particle	NOUN
can-1768	5	23	size	size	NOUN
can-1768	5	24	,	,	PUNCT
can-1768	5	25	entrapment	entrapment	ADJ
can-1768	5	26	efficiency	efficiency	NOUN
can-1768	5	27	,	,	PUNCT
can-1768	5	28	and	and	CCONJ
can-1768	5	29	drug	drug	NOUN
can-1768	5	30	loading	loading	NOUN
can-1768	5	31	of	of	ADP
can-1768	5	32	cisplatin	cisplatin	NOUN
can-1768	5	33	plga	plga	NOUN
can-1768	5	34	nanoparticles	nanoparticle	NOUN
can-1768	5	35	as	as	ADP
can-1768	5	36	responses	response	NOUN
can-1768	5	37	.	.	PUNCT
can-1768	6	1	the	the	DET
can-1768	6	2	results	result	NOUN
can-1768	6	3	revealed	reveal	VERB
can-1768	6	4	that	that	SCONJ
can-1768	6	5	this	this	DET
can-1768	6	6	response	response	NOUN
can-1768	6	7	surface	surface	NOUN
can-1768	6	8	approach	approach	NOUN
can-1768	6	9	might	might	AUX
can-1768	6	10	be	be	AUX
can-1768	6	11	able	able	ADJ
can-1768	6	12	to	to	PART
can-1768	6	13	be	be	AUX
can-1768	6	14	used	use	VERB
can-1768	6	15	to	to	PART
can-1768	6	16	find	find	VERB
can-1768	6	17	the	the	DET
can-1768	6	18	best	good	ADJ
can-1768	6	19	formulation	formulation	NOUN
can-1768	6	20	for	for	ADP
can-1768	6	21	the	the	DET
can-1768	6	22	cisplatin	cisplatin	NOUN
can-1768	6	23	plga	plga	NOUN
can-1768	6	24	nanoparticles	nanoparticle	NOUN
can-1768	6	25	.	.	PUNCT
can-1768	7	1	a	a	DET
can-1768	7	2	polymer	polymer	NOUN
can-1768	7	3	ratio	ratio	NOUN
can-1768	7	4	of	of	ADP
can-1768	7	5	1:8.27	1:8.27	NUM
can-1768	7	6	,	,	PUNCT
can-1768	7	7	organic	organic	ADJ
can-1768	7	8	phase	phase	NOUN
can-1768	7	9	ratio	ratio	NOUN
can-1768	7	10	of	of	ADP
can-1768	7	11	1:6	1:6	NUM
can-1768	7	12	,	,	PUNCT
can-1768	7	13	and	and	CCONJ
can-1768	7	14	stabilizer	stabilizer	NOUN
can-1768	7	15	concentration	concentration	NOUN
can-1768	7	16	of	of	ADP
can-1768	7	17	0.15	0.15	NUM
can-1768	7	18	were	be	AUX
can-1768	7	19	found	find	VERB
can-1768	7	20	to	to	PART
can-1768	7	21	be	be	AUX
can-1768	7	22	optimum	optimum	ADJ
can-1768	7	23	for	for	ADP
can-1768	7	24	cisplatin	cisplatin	NOUN
can-1768	7	25	plga	plga	NOUN
can-1768	7	26	nanoparticles	nanoparticle	NOUN
can-1768	7	27	.	.	PUNCT
can-1768	8	1	nanoparticles	nanoparticle	NOUN
can-1768	8	2	made	make	VERB
can-1768	8	3	under	under	ADP
can-1768	8	4	the	the	DET
can-1768	8	5	optimal	optimal	ADJ
can-1768	8	6	conditions	condition	NOUN
can-1768	8	7	found	find	VERB
can-1768	8	8	yielded	yield	VERB
can-1768	8	9	a	a	DET
can-1768	8	10	112	112	NUM
can-1768	8	11	nm	nm	ADJ
can-1768	8	12	particle	particle	NOUN
can-1768	8	13	size	size	NOUN
can-1768	8	14	and	and	CCONJ
can-1768	8	15	a	a	DET
can-1768	8	16	95.4	95.4	NUM
can-1768	8	17	percent	percent	NOUN
can-1768	8	18	entrapment	entrapment	ADJ
can-1768	8	19	efficiency	efficiency	NOUN
can-1768	8	20	,	,	PUNCT
can-1768	8	21	as	as	ADV
can-1768	8	22	well	well	ADV
can-1768	8	23	as	as	ADP
can-1768	8	24	a	a	DET
can-1768	8	25	drug	drug	NOUN
can-1768	8	26	loading	loading	NOUN
can-1768	8	27	of	of	ADP
can-1768	8	28	9	9	NUM
can-1768	8	29	percent	percent	NOUN
can-1768	8	30	.	.	PUNCT
can-1768	9	1	the	the	DET
can-1768	9	2	cisplatin	cisplatin	NOUN
can-1768	9	3	plga	plga	NOUN
can-1768	9	4	nanoparticles	nanoparticle	NOUN
can-1768	9	5	tailored	tailor	VERB
can-1768	9	6	for	for	ADP
can-1768	9	7	scanning	scan	VERB
can-1768	9	8	electon	electon	PROPN
can-1768	9	9	microscopy	microscopy	NOUN
can-1768	9	10	displayed	display	VERB
can-1768	9	11	a	a	DET
can-1768	9	12	spherical	spherical	ADJ
can-1768	9	13	form	form	NOUN
can-1768	9	14	.	.	PUNCT
can-1768	10	1	a	a	DET
can-1768	10	2	series	series	NOUN
can-1768	10	3	of	of	ADP
can-1768	10	4	in	in	ADP
can-1768	10	5	vitro	vitro	X
can-1768	10	6	tests	test	NOUN
can-1768	10	7	showed	show	VERB
can-1768	10	8	that	that	SCONJ
can-1768	10	9	the	the	DET
can-1768	10	10	nanoparticle	nanoparticle	NOUN
can-1768	10	11	delivered	deliver	VERB
can-1768	10	12	cisplatin	cisplatin	NOUN
can-1768	10	13	progressively	progressively	ADV
can-1768	10	14	over	over	ADP
can-1768	10	15	time	time	NOUN
can-1768	10	16	.	.	PUNCT
can-1768	11	1	according	accord	VERB
can-1768	11	2	to	to	ADP
can-1768	11	3	this	this	DET
can-1768	11	4	work	work	NOUN
can-1768	11	5	,	,	PUNCT
can-1768	11	6	the	the	DET
can-1768	11	7	response	response	NOUN
can-1768	11	8	surface	surface	NOUN
can-1768	11	9	methodology	methodology	NOUN
can-1768	11	10	(	(	PUNCT
can-1768	11	11	rsm	rsm	PROPN
can-1768	11	12	)	)	PUNCT
can-1768	11	13	employing	employ	VERB
can-1768	11	14	the	the	DET
can-1768	11	15	central	central	ADJ
can-1768	11	16	composite	composite	ADJ
can-1768	11	17	rotatable	rotatable	ADJ
can-1768	11	18	design	design	NOUN
can-1768	11	19	may	may	AUX
can-1768	11	20	be	be	AUX
can-1768	11	21	successfully	successfully	ADV
can-1768	11	22	used	use	VERB
can-1768	11	23	to	to	PART
can-1768	11	24	simulate	simulate	VERB
can-1768	11	25	cisplatin	cisplatin	NOUN
can-1768	11	26	-	-	PUNCT
can-1768	11	27	plga	plga	NOUN
can-1768	11	28	nanoparticles	nanoparticle	NOUN
can-1768	11	29	.	.	PUNCT
can-1768	12	1	keywords	keyword	NOUN
can-1768	12	2	:	:	PUNCT
can-1768	12	3	cisplatin	cisplatin	NOUN
can-1768	12	4	;	;	PUNCT
can-1768	12	5	plga	plga	NOUN
can-1768	12	6	;	;	PUNCT
can-1768	12	7	nanoparticles	nanoparticle	NOUN
can-1768	12	8	;	;	PUNCT
can-1768	12	9	response	response	NOUN
can-1768	12	10	surface	surface	NOUN
can-1768	12	11	methodology	methodology	NOUN
can-1768	12	12	;	;	PUNCT
can-1768	12	13	central	central	ADJ
can-1768	12	14	composite	composite	ADJ
can-1768	12	15	rotatable	rotatable	ADJ
can-1768	12	16	design	design	NOUN
can-1768	12	17	article	article	NOUN
can-1768	12	18	info	info	NOUN
can-1768	12	19	received	receive	VERB
can-1768	12	20	:	:	PUNCT
can-1768	12	21	2	2	NUM
can-1768	12	22	august	august	PROPN
can-1768	12	23	2022	2022	NUM
can-1768	12	24	accepted	accept	VERB
can-1768	12	25	:	:	PUNCT
can-1768	12	26	28	28	NUM
can-1768	12	27	september	september	PROPN
can-1768	12	28	2022	2022	NUM
can-1768	12	29	available	available	ADJ
can-1768	12	30	online	online	ADV
can-1768	12	31	:	:	PUNCT
can-1768	12	32	12	12	NUM
can-1768	12	33	october	october	PROPN
can-1768	12	34	2022	2022	NUM
can-1768	12	35	copyright	copyright	NOUN
can-1768	12	36	copyright	copyright	NOUN
can-1768	12	37	©	©	ADP
can-1768	12	38	2022	2022	NUM
can-1768	12	39	by	by	ADP
can-1768	12	40	purushothaman	purushothaman	NOUN
can-1768	12	41	bhuvaneshwaran	bhuvaneshwaran	VERB
can-1768	12	42	,	,	PUNCT
can-1768	12	43	et	et	PROPN
can-1768	12	44	al	al	PROPN
can-1768	12	45	.	.	PROPN
can-1768	12	46	enpress	enpress	PROPN
can-1768	12	47	publisher	publisher	PROPN
can-1768	12	48	llc	llc	PROPN
can-1768	12	49	.	.	PUNCT
can-1768	13	1	this	this	DET
can-1768	13	2	work	work	NOUN
can-1768	13	3	is	be	AUX
can-1768	13	4	licensed	license	VERB
can-1768	13	5	under	under	ADP
can-1768	13	6	the	the	DET
can-1768	13	7	creative	creative	ADJ
can-1768	13	8	commons	common	NOUN
can-1768	13	9	attribution	attribution	NOUN
can-1768	13	10	-	-	PUNCT
can-1768	13	11	noncommercial	noncommercial	ADJ
can-1768	13	12	4.0	4.0	NUM
can-1768	13	13	international	international	ADJ
can-1768	13	14	license	license	NOUN
can-1768	13	15	(	(	PUNCT
can-1768	13	16	cc	cc	NOUN
can-1768	13	17	by	by	ADP
can-1768	13	18	-	-	PUNCT
can-1768	13	19	nc	nc	PROPN
can-1768	13	20	4.0	4.0	NUM
can-1768	13	21	)	)	PUNCT
can-1768	13	22	.	.	PUNCT
can-1768	14	1	https://creativecommons.org/licenses/bync/4.0/	https://creativecommons.org/licenses/bync/4.0/	PROPN
can-1768	14	2	1	1	X
can-1768	14	3	.	.	X
can-1768	15	1	introduction	introduction	NOUN
can-1768	15	2	tumors	tumor	NOUN
can-1768	15	3	form	form	VERB
can-1768	15	4	when	when	SCONJ
can-1768	15	5	cells	cell	NOUN
can-1768	15	6	grow	grow	VERB
can-1768	15	7	and	and	CCONJ
can-1768	15	8	divide	divide	VERB
can-1768	15	9	improperly	improperly	ADV
can-1768	15	10	and	and	CCONJ
can-1768	15	11	uncontrollably	uncontrollably	ADV
can-1768	15	12	,	,	PUNCT
can-1768	15	13	which	which	PRON
can-1768	15	14	is	be	AUX
can-1768	15	15	the	the	DET
can-1768	15	16	hallmark	hallmark	NOUN
can-1768	15	17	of	of	ADP
can-1768	15	18	the	the	DET
can-1768	15	19	cancerous	cancerous	ADJ
can-1768	15	20	condition	condition	NOUN
can-1768	15	21	.	.	PUNCT
can-1768	16	1	new	new	ADJ
can-1768	16	2	technologies	technology	NOUN
can-1768	16	3	that	that	PRON
can-1768	16	4	can	can	AUX
can-1768	16	5	distinguish	distinguish	VERB
can-1768	16	6	between	between	ADP
can-1768	16	7	healthy	healthy	ADJ
can-1768	16	8	and	and	CCONJ
can-1768	16	9	cancerous	cancerous	ADJ
can-1768	16	10	cells	cell	NOUN
can-1768	16	11	followed	follow	VERB
can-1768	16	12	by	by	ADP
can-1768	16	13	the	the	DET
can-1768	16	14	targeting	targeting	NOUN
can-1768	16	15	of	of	ADP
can-1768	16	16	the	the	DET
can-1768	16	17	tumor	tumor	NOUN
can-1768	16	18	with	with	ADP
can-1768	16	19	precision	precision	NOUN
can-1768	16	20	are	be	AUX
can-1768	16	21	attracting	attract	VERB
can-1768	16	22	a	a	DET
can-1768	16	23	lot	lot	NOUN
can-1768	16	24	of	of	ADP
can-1768	16	25	attention	attention	NOUN
can-1768	16	26	.	.	PUNCT
can-1768	17	1	with	with	ADP
can-1768	17	2	(	(	PUNCT
can-1768	17	3	transdermal	transdermal	ADJ
can-1768	17	4	drug	drug	NOUN
can-1768	17	5	delivery	delivery	NOUN
can-1768	17	6	)	)	PUNCT
can-1768	17	7	tdd	tdd	NOUN
can-1768	17	8	,	,	PUNCT
can-1768	17	9	the	the	DET
can-1768	17	10	medicine	medicine	NOUN
can-1768	17	11	is	be	AUX
can-1768	17	12	encapsulated	encapsulate	VERB
can-1768	17	13	inside	inside	ADV
can-1768	17	14	of	of	ADP
can-1768	17	15	a	a	DET
can-1768	17	16	nanocarrier	nanocarrier	NOUN
can-1768	17	17	like	like	ADP
can-1768	17	18	liposomes	liposome	NOUN
can-1768	17	19	or	or	CCONJ
can-1768	17	20	liposomal	liposomal	ADJ
can-1768	17	21	particles	particle	NOUN
can-1768	17	22	to	to	PART
can-1768	17	23	transport	transport	VERB
can-1768	17	24	it	it	PRON
can-1768	17	25	directly	directly	ADV
can-1768	17	26	to	to	ADP
can-1768	17	27	the	the	DET
can-1768	17	28	patient	patient	NOUN
can-1768	17	29	.	.	PUNCT
can-1768	18	1	both	both	CCONJ
can-1768	18	2	the	the	DET
can-1768	18	3	effectiveness	effectiveness	NOUN
can-1768	18	4	and	and	CCONJ
can-1768	18	5	toxicity	toxicity	NOUN
can-1768	18	6	of	of	ADP
can-1768	18	7	the	the	DET
can-1768	18	8	medicine	medicine	NOUN
can-1768	18	9	may	may	AUX
can-1768	18	10	be	be	AUX
can-1768	18	11	improved	improve	VERB
can-1768	18	12	by	by	ADP
can-1768	18	13	tdd	tdd	NOUN
can-1768	18	14	,	,	PUNCT
can-1768	18	15	and	and	CCONJ
can-1768	18	16	it	it	PRON
can-1768	18	17	can	can	AUX
can-1768	18	18	overcome	overcome	VERB
can-1768	18	19	a	a	DET
can-1768	18	20	broad	broad	ADJ
can-1768	18	21	variety	variety	NOUN
can-1768	18	22	of	of	ADP
can-1768	18	23	difficulties	difficulty	NOUN
can-1768	18	24	,	,	PUNCT
can-1768	18	25	such	such	ADJ
can-1768	18	26	as	as	ADP
can-1768	18	27	drug	drug	NOUN
can-1768	18	28	solubility	solubility	NOUN
can-1768	18	29	and	and	CCONJ
can-1768	18	30	instability	instability	NOUN
can-1768	18	31	,	,	PUNCT
can-1768	18	32	and	and	CCONJ
can-1768	18	33	the	the	DET
can-1768	18	34	ease	ease	NOUN
can-1768	18	35	of	of	ADP
can-1768	18	36	delivery	delivery	NOUN
can-1768	18	37	to	to	ADP
can-1768	18	38	the	the	DET
can-1768	18	39	target	target	NOUN
can-1768	18	40	cells	cell	NOUN
can-1768	18	41	.	.	PUNCT
can-1768	19	1	passive	passive	ADJ
can-1768	19	2	and	and	CCONJ
can-1768	19	3	active	active	ADJ
can-1768	19	4	medication	medication	NOUN
can-1768	19	5	targeting	target	VERB
can-1768	19	6	methods	method	NOUN
can-1768	19	7	are	be	AUX
can-1768	19	8	available[1	available[1	NOUN
can-1768	19	9	]	]	X
can-1768	19	10	.	.	PUNCT
can-1768	20	1	on	on	ADP
can-1768	20	2	the	the	DET
can-1768	20	3	basis	basis	NOUN
can-1768	20	4	of	of	ADP
can-1768	20	5	the	the	DET
can-1768	20	6	enhanced	enhanced	ADJ
can-1768	20	7	permeability	permeability	NOUN
can-1768	20	8	and	and	CCONJ
can-1768	20	9	retention	retention	NOUN
can-1768	20	10	(	(	PUNCT
can-1768	20	11	epr	epr	ADJ
can-1768	20	12	)	)	PUNCT
can-1768	20	13	effect	effect	NOUN
can-1768	20	14	,	,	PUNCT
can-1768	20	15	which	which	PRON
can-1768	20	16	occurs	occur	VERB
can-1768	20	17	in	in	ADP
can-1768	20	18	most	most	ADV
can-1768	20	19	solid	solid	ADJ
can-1768	20	20	tumors	tumor	NOUN
can-1768	20	21	,	,	PUNCT
can-1768	20	22	passive	passive	ADJ
can-1768	20	23	targeting	targeting	NOUN
can-1768	20	24	relies	relie	NOUN
can-1768	20	25	on	on	ADP
can-1768	20	26	molecules	molecule	NOUN
can-1768	20	27	of	of	ADP
can-1768	20	28	specific	specific	ADJ
can-1768	20	29	sizes	size	NOUN
can-1768	20	30	being	be	AUX
can-1768	20	31	preferentially	preferentially	ADV
can-1768	20	32	taken	take	VERB
can-1768	20	33	up	up	ADP
can-1768	20	34	and	and	CCONJ
can-1768	20	35	retained	retain	VERB
can-1768	20	36	by	by	ADP
can-1768	20	37	the	the	DET
can-1768	20	38	tumors[2	tumors[2	PROPN
can-1768	20	39	]	]	PUNCT
can-1768	20	40	.	.	PUNCT
can-1768	21	1	however	however	ADV
can-1768	21	2	,	,	PUNCT
can-1768	21	3	the	the	DET
can-1768	21	4	reticuloendothelial	reticuloendothelial	ADJ
can-1768	21	5	system	system	NOUN
can-1768	21	6	(	(	PUNCT
can-1768	21	7	res	re	NOUN
can-1768	21	8	)	)	PUNCT
can-1768	21	9	rapidly	rapidly	ADV
can-1768	21	10	removes	remove	VERB
can-1768	21	11	intravenously	intravenously	ADV
can-1768	21	12	delivered	deliver	VERB
can-1768	21	13	nanocarriers	nanocarrier	NOUN
can-1768	21	14	containing	contain	VERB
can-1768	21	15	anticancer	anticancer	NOUN
can-1768	21	16	medicines	medicine	NOUN
can-1768	21	17	from	from	ADP
can-1768	21	18	circulation	circulation	NOUN
can-1768	21	19	.	.	PUNCT
can-1768	22	1	these	these	DET
can-1768	22	2	nanocarriers	nanocarrier	NOUN
can-1768	22	3	have	have	VERB
can-1768	22	4	a	a	DET
can-1768	22	5	hydrophilic	hydrophilic	ADJ
can-1768	22	6	polymer	polymer	NOUN
can-1768	22	7	,	,	PUNCT
can-1768	22	8	for	for	ADP
can-1768	22	9	example	example	NOUN
can-1768	22	10	,	,	PUNCT
can-1768	22	11	polyethylene	polyethylene	NOUN
can-1768	22	12	glycol	glycol	NOUN
can-1768	22	13	(	(	PUNCT
can-1768	22	14	peg	peg	NOUN
can-1768	22	15	)	)	PUNCT
can-1768	22	16	coating	coating	NOUN
can-1768	22	17	applied	apply	VERB
can-1768	22	18	on	on	ADP
can-1768	22	19	top	top	NOUN
can-1768	22	20	of	of	ADP
can-1768	22	21	them	they	PRON
can-1768	22	22	to	to	PART
can-1768	22	23	increase	increase	VERB
can-1768	22	24	their	their	PRON
can-1768	22	25	circulation	circulation	NOUN
can-1768	22	26	duration	duration	NOUN
can-1768	22	27	and	and	CCONJ
can-1768	22	28	consequently	consequently	ADV
can-1768	22	29	100	100	NUM
can-1768	22	30	their	their	PRON
can-1768	22	31	targeting	targeting	NOUN
can-1768	22	32	of	of	ADP
can-1768	22	33	tumor	tumor	NOUN
can-1768	22	34	tissue[3	tissue[3	NOUN
can-1768	22	35	]	]	PUNCT
can-1768	22	36	.	.	PUNCT
can-1768	23	1	the	the	DET
can-1768	23	2	adsorption	adsorption	NOUN
can-1768	23	3	of	of	ADP
can-1768	23	4	plasma	plasma	NOUN
can-1768	23	5	proteins	protein	NOUN
can-1768	23	6	(	(	PUNCT
can-1768	23	7	opsonin	opsonin	NOUN
can-1768	23	8	)	)	PUNCT
can-1768	23	9	,	,	PUNCT
can-1768	23	10	which	which	PRON
can-1768	23	11	is	be	AUX
can-1768	23	12	critical	critical	ADJ
can-1768	23	13	for	for	ADP
can-1768	23	14	phagocytosis	phagocytosis	NOUN
can-1768	23	15	,	,	PUNCT
can-1768	23	16	would	would	AUX
can-1768	23	17	be	be	AUX
can-1768	23	18	prevented	prevent	VERB
can-1768	23	19	,	,	PUNCT
can-1768	23	20	resulting	result	VERB
can-1768	23	21	in	in	ADP
can-1768	23	22	a	a	DET
can-1768	23	23	longer	long	ADJ
can-1768	23	24	period	period	NOUN
can-1768	23	25	for	for	ADP
can-1768	23	26	blood	blood	NOUN
can-1768	23	27	to	to	ADP
can-1768	23	28	circulate[4,5	circulate[4,5	NOUN
can-1768	23	29	]	]	PUNCT
can-1768	23	30	.	.	PUNCT
can-1768	24	1	nanoparticles	nanoparticle	NOUN
can-1768	24	2	(	(	PUNCT
can-1768	24	3	nps	nps	PROPN
can-1768	24	4	)	)	PUNCT
can-1768	24	5	are	be	AUX
can-1768	24	6	regarded	regard	VERB
can-1768	24	7	as	as	ADP
can-1768	24	8	drug	drug	NOUN
can-1768	24	9	delivery	delivery	NOUN
can-1768	24	10	mechanism	mechanism	NOUN
can-1768	24	11	that	that	PRON
can-1768	24	12	allows	allow	VERB
can-1768	24	13	for	for	ADP
can-1768	24	14	novel	novel	ADJ
can-1768	24	15	approaches	approach	NOUN
can-1768	24	16	to	to	ADP
can-1768	24	17	cancer	cancer	NOUN
can-1768	24	18	therapy	therapy	NOUN
can-1768	24	19	,	,	PUNCT
can-1768	24	20	and	and	CCONJ
can-1768	24	21	one	one	NUM
can-1768	24	22	of	of	ADP
can-1768	24	23	the	the	DET
can-1768	24	24	most	most	ADV
can-1768	24	25	important	important	ADJ
can-1768	24	26	methods	method	NOUN
can-1768	24	27	used	use	VERB
can-1768	24	28	in	in	ADP
can-1768	24	29	nanomedicine	nanomedicine	NOUN
can-1768	24	30	.	.	PUNCT
can-1768	25	1	there	there	PRON
can-1768	25	2	are	be	VERB
can-1768	25	3	several	several	ADJ
can-1768	25	4	np	np	NOUN
can-1768	25	5	delivery	delivery	NOUN
can-1768	25	6	techniques	technique	NOUN
can-1768	25	7	,	,	PUNCT
can-1768	25	8	in	in	ADP
can-1768	25	9	which	which	PRON
can-1768	25	10	the	the	DET
can-1768	25	11	medication	medication	NOUN
can-1768	25	12	is	be	AUX
can-1768	25	13	dissolved	dissolve	VERB
can-1768	25	14	,	,	PUNCT
can-1768	25	15	encapsulated	encapsulate	VERB
can-1768	25	16	,	,	PUNCT
can-1768	25	17	and	and	CCONJ
can-1768	25	18	entrapped	entrap	VERB
can-1768	25	19	inside	inside	ADP
can-1768	25	20	the	the	DET
can-1768	25	21	matrix[6	matrix[6	NOUN
can-1768	25	22	]	]	X
can-1768	25	23	.	.	PUNCT
can-1768	26	1	the	the	DET
can-1768	26	2	potential	potential	NOUN
can-1768	26	3	of	of	ADP
can-1768	26	4	nps	nps	PROPN
can-1768	26	5	coupled	couple	VERB
can-1768	26	6	with	with	ADP
can-1768	26	7	biodegradable	biodegradable	ADJ
can-1768	26	8	polymers	polymer	NOUN
can-1768	26	9	such	such	ADJ
can-1768	26	10	as	as	ADP
can-1768	26	11	plga	plga	NOUN
can-1768	26	12	to	to	PART
can-1768	26	13	actively	actively	ADV
can-1768	26	14	and	and	CCONJ
can-1768	26	15	passively	passively	ADV
can-1768	26	16	target	target	NOUN
can-1768	26	17	tumors	tumor	NOUN
can-1768	26	18	has	have	AUX
can-1768	26	19	drawn	draw	VERB
can-1768	26	20	considerable	considerable	ADJ
can-1768	26	21	interest[7	interest[7	NOUN
can-1768	26	22	]	]	PUNCT
can-1768	26	23	.	.	PUNCT
can-1768	27	1	the	the	DET
can-1768	27	2	exterior	exterior	ADJ
can-1768	27	3	diameters	diameter	NOUN
can-1768	27	4	of	of	ADP
can-1768	27	5	nps	nps	PROPN
can-1768	27	6	can	can	AUX
can-1768	27	7	range	range	VERB
can-1768	27	8	from	from	ADP
can-1768	27	9	a	a	DET
can-1768	27	10	few	few	ADJ
can-1768	27	11	nanometers	nanometer	NOUN
can-1768	27	12	to	to	ADP
can-1768	27	13	over	over	ADP
can-1768	27	14	1,000	1,000	NUM
can-1768	27	15	nanometers	nanometer	NOUN
can-1768	27	16	in	in	ADP
can-1768	27	17	length	length	NOUN
can-1768	27	18	.	.	PUNCT
can-1768	28	1	due	due	ADP
can-1768	28	2	to	to	ADP
can-1768	28	3	the	the	DET
can-1768	28	4	epr	epr	PROPN
can-1768	28	5	effect	effect	NOUN
can-1768	28	6	,	,	PUNCT
can-1768	28	7	nps	nps	PROPN
can-1768	28	8	coated	coat	VERB
can-1768	28	9	with	with	ADP
can-1768	28	10	peg	peg	NOUN
can-1768	28	11	can	can	AUX
can-1768	28	12	accumulate	accumulate	VERB
can-1768	28	13	in	in	ADP
can-1768	28	14	a	a	DET
can-1768	28	15	variety	variety	NOUN
can-1768	28	16	of	of	ADP
can-1768	28	17	solid	solid	ADJ
can-1768	28	18	tumors	tumor	NOUN
can-1768	28	19	,	,	PUNCT
can-1768	28	20	making	make	VERB
can-1768	28	21	them	they	PRON
can-1768	28	22	ideal	ideal	ADJ
can-1768	28	23	carriers	carrier	NOUN
can-1768	28	24	for	for	ADP
can-1768	28	25	hydrophobic	hydrophobic	NOUN
can-1768	28	26	medicines	medicine	NOUN
can-1768	28	27	,	,	PUNCT
can-1768	28	28	which	which	PRON
can-1768	28	29	can	can	AUX
can-1768	28	30	provide	provide	VERB
can-1768	28	31	effective	effective	ADJ
can-1768	28	32	tumor	tumor	NOUN
can-1768	28	33	targeting	target	VERB
can-1768	28	34	with	with	ADP
can-1768	28	35	the	the	DET
can-1768	28	36	fewest	few	ADJ
can-1768	28	37	adverse	adverse	ADJ
can-1768	28	38	responses[8,9	responses[8,9	NOUN
can-1768	28	39	]	]	PUNCT
can-1768	28	40	.	.	PUNCT
can-1768	29	1	nanoprecipitation[10	nanoprecipitation[10	PRON
can-1768	29	2	]	]	PUNCT
can-1768	29	3	,	,	PUNCT
can-1768	29	4	solvent	solvent	NOUN
can-1768	29	5	evaporation[11	evaporation[11	NOUN
can-1768	29	6	]	]	X
can-1768	29	7	,	,	PUNCT
can-1768	29	8	dialysis[12	dialysis[12	NOUN
can-1768	29	9	]	]	PUNCT
can-1768	29	10	,	,	PUNCT
can-1768	29	11	and	and	CCONJ
can-1768	29	12	salting	salt	VERB
can-1768	29	13	out[13	out[13	PROPN
can-1768	29	14	]	]	PUNCT
can-1768	29	15	have	have	AUX
can-1768	29	16	all	all	PRON
can-1768	29	17	been	be	AUX
can-1768	29	18	used	use	VERB
can-1768	29	19	for	for	ADP
can-1768	29	20	the	the	DET
can-1768	29	21	formation	formation	NOUN
can-1768	29	22	of	of	ADP
can-1768	29	23	nps	nps	PROPN
can-1768	29	24	.	.	PUNCT
can-1768	30	1	for	for	ADP
can-1768	30	2	the	the	DET
can-1768	30	3	treatment	treatment	NOUN
can-1768	30	4	of	of	ADP
can-1768	30	5	a	a	DET
can-1768	30	6	wide	wide	ADJ
can-1768	30	7	range	range	NOUN
can-1768	30	8	of	of	ADP
can-1768	30	9	solid	solid	ADJ
can-1768	30	10	malignancies	malignancy	NOUN
can-1768	30	11	,	,	PUNCT
can-1768	30	12	including	include	VERB
can-1768	30	13	cervical	cervical	ADJ
can-1768	30	14	cancer	cancer	NOUN
can-1768	30	15	,	,	PUNCT
can-1768	30	16	cisplatin	cisplatin	NOUN
can-1768	30	17	is	be	AUX
can-1768	30	18	a	a	DET
can-1768	30	19	powerful	powerful	ADJ
can-1768	30	20	anticancer	anticancer	NOUN
can-1768	30	21	drug[14	drug[14	PROPN
can-1768	30	22	]	]	PUNCT
can-1768	30	23	.	.	PUNCT
can-1768	31	1	in	in	ADP
can-1768	31	2	order	order	NOUN
can-1768	31	3	to	to	PART
can-1768	31	4	eliminate	eliminate	VERB
can-1768	31	5	cancer	cancer	NOUN
can-1768	31	6	cells	cell	NOUN
can-1768	31	7	,	,	PUNCT
can-1768	31	8	cisplatin	cisplatin	NOUN
can-1768	31	9	causes	cause	VERB
can-1768	31	10	cross	cross	ADJ
can-1768	31	11	-	-	ADJ
can-1768	31	12	linking	linking	NOUN
can-1768	31	13	of	of	ADP
can-1768	31	14	dna	dna	PROPN
can-1768	31	15	,	,	PUNCT
can-1768	31	16	which	which	PRON
can-1768	31	17	leads	lead	VERB
can-1768	31	18	to	to	ADP
can-1768	31	19	cell	cell	NOUN
can-1768	31	20	death	death	NOUN
can-1768	31	21	.	.	PUNCT
can-1768	32	1	although	although	SCONJ
can-1768	32	2	cisplatin	cisplatin	NOUN
can-1768	32	3	has	have	VERB
can-1768	32	4	a	a	DET
can-1768	32	5	powerful	powerful	ADJ
can-1768	32	6	anticancer	anticancer	NOUN
can-1768	32	7	impact	impact	NOUN
can-1768	32	8	,	,	PUNCT
can-1768	32	9	its	its	PRON
can-1768	32	10	severe	severe	ADJ
can-1768	32	11	side	side	NOUN
can-1768	32	12	effects	effect	NOUN
can-1768	32	13	such	such	ADJ
can-1768	32	14	as	as	ADP
can-1768	32	15	nephrological	nephrological	ADJ
can-1768	32	16	and	and	CCONJ
can-1768	32	17	neurological	neurological	ADJ
can-1768	32	18	toxicities[15	toxicities[15	NOUN
can-1768	32	19	]	]	PUNCT
can-1768	32	20	limit	limit	VERB
can-1768	32	21	its	its	PRON
can-1768	32	22	effectiveness	effectiveness	NOUN
can-1768	32	23	.	.	PUNCT
can-1768	33	1	chronic	chronic	ADJ
can-1768	33	2	and	and	CCONJ
can-1768	33	3	acute	acute	PROPN
can-1768	33	4	kidney	kidney	NOUN
can-1768	33	5	damage	damage	NOUN
can-1768	33	6	are	be	AUX
can-1768	33	7	common	common	ADJ
can-1768	33	8	side	side	NOUN
can-1768	33	9	effects	effect	NOUN
can-1768	33	10	of	of	ADP
can-1768	33	11	cisplatin	cisplatin	NOUN
can-1768	33	12	,	,	PUNCT
can-1768	33	13	while	while	SCONJ
can-1768	33	14	neurotoxicity	neurotoxicity	NOUN
can-1768	33	15	is	be	AUX
can-1768	33	16	cumulative	cumulative	ADJ
can-1768	33	17	-	-	PUNCT
can-1768	33	18	dose	dose	VERB
can-1768	33	19	dependent	dependent	NOUN
can-1768	33	20	.	.	PUNCT
can-1768	34	1	cisplatin	cisplatin	NOUN
can-1768	34	2	’s	’s	PART
can-1768	34	3	immediate	immediate	ADJ
can-1768	34	4	inactivation	inactivation	NOUN
can-1768	34	5	in	in	ADP
can-1768	34	6	the	the	DET
can-1768	34	7	systemic	systemic	ADJ
can-1768	34	8	circulation	circulation	NOUN
can-1768	34	9	is	be	AUX
can-1768	34	10	one	one	NUM
can-1768	34	11	of	of	ADP
can-1768	34	12	the	the	DET
can-1768	34	13	greatest	great	ADJ
can-1768	34	14	concerns[16,17	concerns[16,17	PROPN
can-1768	34	15	]	]	PUNCT
can-1768	34	16	.	.	PUNCT
can-1768	35	1	as	as	ADP
can-1768	35	2	a	a	DET
can-1768	35	3	result	result	NOUN
can-1768	35	4	,	,	PUNCT
can-1768	35	5	cis	cis	NOUN
can-1768	35	6	-	-	PUNCT
can-1768	35	7	dichlorodiammineplatinum	dichlorodiammineplatinum	ADJ
can-1768	35	8	(	(	PUNCT
can-1768	35	9	ii	ii	NOUN
can-1768	35	10	)	)	PUNCT
can-1768	35	11	(	(	PUNCT
can-1768	35	12	cis-[ptcl2(nh3)2	cis-[ptcl2(nh3)2	PROPN
can-1768	35	13	]	]	X
can-1768	35	14	,	,	PUNCT
can-1768	35	15	cisplatin	cisplatin	NOUN
can-1768	35	16	(	(	PUNCT
can-1768	35	17	cddp	cddp	PROPN
can-1768	35	18	’s	’s	PART
can-1768	35	19	)	)	PUNCT
can-1768	35	20	pharmacological	pharmacological	ADJ
can-1768	35	21	effect	effect	NOUN
can-1768	35	22	must	must	AUX
can-1768	35	23	be	be	AUX
can-1768	35	24	protected	protect	VERB
can-1768	35	25	and	and	CCONJ
can-1768	35	26	its	its	PRON
can-1768	35	27	systemic	systemic	ADJ
can-1768	35	28	circulation	circulation	NOUN
can-1768	35	29	must	must	AUX
can-1768	35	30	be	be	AUX
can-1768	35	31	prolonged	prolong	VERB
can-1768	35	32	.	.	PUNCT
can-1768	36	1	drug	drug	NOUN
can-1768	36	2	must	must	AUX
can-1768	36	3	be	be	AUX
can-1768	36	4	delivered	deliver	VERB
can-1768	36	5	over	over	ADP
can-1768	36	6	an	an	DET
can-1768	36	7	extended	extended	ADJ
can-1768	36	8	period	period	NOUN
can-1768	36	9	of	of	ADP
can-1768	36	10	time	time	NOUN
can-1768	36	11	in	in	ADP
can-1768	36	12	order	order	NOUN
can-1768	36	13	to	to	PART
can-1768	36	14	maximise	maximise	VERB
can-1768	36	15	its	its	PRON
can-1768	36	16	anticancer	anticancer	NOUN
can-1768	36	17	properties	property	NOUN
can-1768	36	18	and	and	CCONJ
can-1768	36	19	minimise	minimise	VERB
can-1768	36	20	its	its	PRON
can-1768	36	21	negative	negative	ADJ
can-1768	36	22	effects	effect	NOUN
can-1768	36	23	.	.	PUNCT
can-1768	37	1	for	for	ADP
can-1768	37	2	passive	passive	ADJ
can-1768	37	3	targeting	targeting	NOUN
can-1768	37	4	following	follow	VERB
can-1768	37	5	intravenous	intravenous	ADJ
can-1768	37	6	delivery	delivery	NOUN
can-1768	37	7	,	,	PUNCT
can-1768	37	8	researchers	researcher	NOUN
can-1768	37	9	are	be	AUX
can-1768	37	10	trying	try	VERB
can-1768	37	11	to	to	PART
can-1768	37	12	integrate	integrate	VERB
can-1768	37	13	cisplatin	cisplatin	NOUN
can-1768	37	14	into	into	ADP
can-1768	37	15	poly	poly	ADJ
can-1768	37	16	(	(	PUNCT
can-1768	37	17	lactic	lactic	ADJ
can-1768	37	18	-	-	PUNCT
can-1768	37	19	coglycolic	coglycolic	NOUN
can-1768	37	20	acid	acid	NOUN
can-1768	37	21	)	)	PUNCT
can-1768	37	22	(	(	PUNCT
can-1768	37	23	plga	plga	NOUN
can-1768	37	24	)	)	PUNCT
can-1768	37	25	nps	nps	PROPN
can-1768	37	26	.	.	PUNCT
can-1768	38	1	response	response	NOUN
can-1768	38	2	surface	surface	PROPN
can-1768	38	3	methodology	methodology	NOUN
can-1768	38	4	central	central	ADJ
can-1768	38	5	composite	composite	ADJ
can-1768	38	6	rotatable	rotatable	ADJ
can-1768	38	7	design	design	NOUN
can-1768	38	8	will	will	AUX
can-1768	38	9	be	be	AUX
can-1768	38	10	used	use	VERB
can-1768	38	11	to	to	PART
can-1768	38	12	optimise	optimise	VERB
can-1768	38	13	the	the	DET
can-1768	38	14	nanoparticles	nanoparticle	NOUN
can-1768	38	15	created	create	VERB
can-1768	38	16	.	.	PUNCT
can-1768	39	1	after	after	ADP
can-1768	39	2	optimizing	optimize	VERB
can-1768	39	3	cisplatin	cisplatin	NOUN
can-1768	39	4	loading	loading	NOUN
can-1768	39	5	,	,	PUNCT
can-1768	39	6	we	we	PRON
can-1768	39	7	will	will	AUX
can-1768	39	8	conduct	conduct	VERB
can-1768	39	9	in	in	ADP
can-1768	39	10	vitro	vitro	X
can-1768	39	11	drug	drug	NOUN
can-1768	39	12	release	release	NOUN
can-1768	39	13	and	and	CCONJ
can-1768	39	14	physicochemical	physicochemical	ADJ
can-1768	39	15	evaluations	evaluation	NOUN
can-1768	39	16	of	of	ADP
can-1768	39	17	the	the	DET
can-1768	39	18	plga	plga	NOUN
can-1768	39	19	nps	nps	PROPN
can-1768	39	20	.	.	PROPN
can-1768	40	1	2	2	NUM
can-1768	40	2	.	.	X
can-1768	40	3	materials	material	NOUN
can-1768	40	4	and	and	CCONJ
can-1768	40	5	method	method	ADJ
can-1768	40	6	dichloromethane	dichloromethane	NOUN
can-1768	40	7	and	and	CCONJ
can-1768	40	8	sodium	sodium	NOUN
can-1768	40	9	cholate	cholate	NOUN
can-1768	40	10	were	be	AUX
can-1768	40	11	provided	provide	VERB
can-1768	40	12	by	by	ADP
can-1768	40	13	madras	madra	NOUN
can-1768	40	14	pharmaceuticals	pharmaceuticals	PROPN
can-1768	40	15	,	,	PUNCT
can-1768	40	16	india	india	PROPN
can-1768	40	17	.	.	PUNCT
can-1768	40	18	cisplatin	cisplatin	NOUN
can-1768	40	19	and	and	CCONJ
can-1768	40	20	plga	plga	NOUN
can-1768	40	21	was	be	AUX
can-1768	40	22	purchased	purchase	VERB
can-1768	40	23	from	from	ADP
can-1768	40	24	sigma	sigma	PROPN
can-1768	40	25	-	-	PUNCT
can-1768	40	26	aldrich	aldrich	PROPN
can-1768	40	27	,	,	PUNCT
can-1768	40	28	india	india	PROPN
can-1768	40	29	.	.	PUNCT
can-1768	41	1	all	all	DET
can-1768	41	2	other	other	ADJ
can-1768	41	3	chemicals	chemical	NOUN
can-1768	41	4	were	be	AUX
can-1768	41	5	of	of	ADP
can-1768	41	6	analytical	analytical	ADJ
can-1768	41	7	grade	grade	NOUN
can-1768	41	8	and	and	CCONJ
can-1768	41	9	used	use	VERB
can-1768	41	10	as	as	ADP
can-1768	41	11	such	such	ADJ
can-1768	41	12	.	.	PUNCT
can-1768	42	1	2.1	2.1	NUM
can-1768	42	2	preparation	preparation	NOUN
can-1768	42	3	of	of	ADP
can-1768	42	4	cisplatin	cisplatin	NOUN
can-1768	42	5	nanoparticles	nanoparticle	NOUN
can-1768	42	6	in	in	ADP
can-1768	42	7	order	order	NOUN
can-1768	42	8	to	to	PART
can-1768	42	9	create	create	VERB
can-1768	42	10	nanoparticles	nanoparticle	NOUN
can-1768	42	11	,	,	PUNCT
can-1768	42	12	a	a	DET
can-1768	42	13	solvent	solvent	ADJ
can-1768	42	14	evaporation	evaporation	NOUN
can-1768	42	15	approach	approach	NOUN
can-1768	42	16	was	be	AUX
can-1768	42	17	used[18	used[18	PROPN
can-1768	42	18	]	]	PUNCT
can-1768	42	19	.	.	PUNCT
can-1768	43	1	sonication	sonication	NOUN
can-1768	43	2	was	be	AUX
can-1768	43	3	used	use	VERB
can-1768	43	4	for	for	ADP
can-1768	43	5	5	5	NUM
can-1768	43	6	min	min	NOUN
can-1768	43	7	to	to	PART
can-1768	43	8	create	create	VERB
can-1768	43	9	an	an	DET
can-1768	43	10	emulsion	emulsion	NOUN
can-1768	43	11	between	between	ADP
can-1768	43	12	an	an	DET
can-1768	43	13	organic	organic	ADJ
can-1768	43	14	polymer	polymer	NOUN
can-1768	43	15	solution	solution	NOUN
can-1768	43	16	(	(	PUNCT
can-1768	43	17	o	o	NOUN
can-1768	43	18	)	)	PUNCT
can-1768	43	19	and	and	CCONJ
can-1768	43	20	an	an	DET
can-1768	43	21	aqueous	aqueous	ADJ
can-1768	43	22	solution	solution	NOUN
can-1768	43	23	(	(	PUNCT
can-1768	43	24	w	w	NOUN
can-1768	43	25	)	)	PUNCT
can-1768	43	26	containing	contain	VERB
can-1768	43	27	the	the	DET
can-1768	43	28	medication	medication	NOUN
can-1768	43	29	(	(	PUNCT
can-1768	43	30	5	5	NUM
can-1768	43	31	mg	mg	NOUN
can-1768	43	32	of	of	ADP
can-1768	43	33	cisplatin	cisplatin	NOUN
can-1768	43	34	in	in	ADP
can-1768	43	35	2	2	NUM
can-1768	43	36	ml	ml	NOUN
can-1768	43	37	distilled	distil	VERB
can-1768	43	38	water	water	NOUN
can-1768	43	39	)	)	PUNCT
can-1768	43	40	.	.	PUNCT
can-1768	44	1	it	it	PRON
can-1768	44	2	was	be	AUX
can-1768	44	3	then	then	ADV
can-1768	44	4	mixed	mix	VERB
can-1768	44	5	with	with	ADP
can-1768	44	6	50	50	NUM
can-1768	44	7	ml	ml	NOUN
can-1768	44	8	of	of	ADP
can-1768	44	9	water	water	NOUN
can-1768	44	10	and	and	CCONJ
can-1768	44	11	sonicated	sonicate	VERB
can-1768	44	12	to	to	PART
can-1768	44	13	create	create	VERB
can-1768	44	14	the	the	DET
can-1768	44	15	double	double	ADJ
can-1768	44	16	-	-	PUNCT
can-1768	44	17	emulsion	emulsion	NOUN
can-1768	44	18	,	,	PUNCT
can-1768	44	19	which	which	PRON
can-1768	44	20	was	be	AUX
can-1768	44	21	then	then	ADV
can-1768	44	22	dissolved	dissolve	VERB
can-1768	44	23	in	in	ADP
can-1768	44	24	an	an	DET
can-1768	44	25	equal	equal	ADJ
can-1768	44	26	amount	amount	NOUN
can-1768	44	27	of	of	ADP
can-1768	44	28	water	water	NOUN
can-1768	44	29	.	.	PUNCT
can-1768	45	1	a	a	DET
can-1768	45	2	mild	mild	ADJ
can-1768	45	3	magnetic	magnetic	ADJ
can-1768	45	4	stirring	stirring	NOUN
can-1768	45	5	at	at	ADP
can-1768	45	6	room	room	NOUN
can-1768	45	7	temperature	temperature	NOUN
can-1768	45	8	was	be	AUX
can-1768	45	9	used	use	VERB
can-1768	45	10	to	to	PART
can-1768	45	11	evaporate	evaporate	VERB
can-1768	45	12	the	the	DET
can-1768	45	13	solvent	solvent	NOUN
can-1768	45	14	.	.	PUNCT
can-1768	46	1	recovered	recover	VERB
can-1768	46	2	nanoparticles	nanoparticle	NOUN
can-1768	46	3	were	be	AUX
can-1768	46	4	rinsed	rinse	VERB
can-1768	46	5	with	with	ADP
can-1768	46	6	distilled	distil	VERB
can-1768	46	7	water	water	NOUN
can-1768	46	8	,	,	PUNCT
can-1768	46	9	dried	dry	VERB
can-1768	46	10	,	,	PUNCT
can-1768	46	11	and	and	CCONJ
can-1768	46	12	kept	keep	VERB
can-1768	46	13	in	in	ADP
can-1768	46	14	cold	cold	ADJ
can-1768	46	15	temperatures	temperature	NOUN
can-1768	46	16	(	(	PUNCT
can-1768	46	17	2–8	2–8	PROPN
can-1768	46	18	°	°	SYM
can-1768	46	19	c	c	NOUN
can-1768	46	20	)	)	PUNCT
can-1768	46	21	for	for	ADP
can-1768	46	22	future	future	ADJ
can-1768	46	23	use	use	NOUN
can-1768	46	24	.	.	PUNCT
can-1768	47	1	2.2	2.2	NUM
can-1768	47	2	experimental	experimental	ADJ
can-1768	47	3	design	design	NOUN
can-1768	47	4	according	accord	VERB
can-1768	47	5	to	to	ADP
can-1768	47	6	preliminary	preliminary	ADJ
can-1768	47	7	investigations	investigation	NOUN
can-1768	47	8	,	,	PUNCT
can-1768	47	9	the	the	DET
can-1768	47	10	variables	variable	NOUN
can-1768	47	11	including	include	VERB
can-1768	47	12	drug	drug	NOUN
can-1768	47	13	polymer	polymer	NOUN
can-1768	47	14	ratio	ratio	NOUN
can-1768	47	15	,	,	PUNCT
can-1768	47	16	water	water	NOUN
can-1768	47	17	to	to	ADP
can-1768	47	18	organic	organic	ADJ
can-1768	47	19	phase	phase	NOUN
can-1768	47	20	ratio	ratio	NOUN
can-1768	47	21	,	,	PUNCT
can-1768	47	22	and	and	CCONJ
can-1768	47	23	stabilizer	stabilizer	NOUN
can-1768	47	24	concentration	concentration	NOUN
can-1768	47	25	during	during	ADP
can-1768	47	26	synthesis	synthesis	NOUN
can-1768	47	27	of	of	ADP
can-1768	47	28	the	the	DET
can-1768	47	29	cisplatin	cisplatin	NOUN
can-1768	47	30	nanoparticles	nanoparticle	NOUN
can-1768	47	31	,	,	PUNCT
can-1768	47	32	had	have	VERB
can-1768	47	33	the	the	DET
can-1768	47	34	greatest	great	ADJ
can-1768	47	35	impact	impact	NOUN
can-1768	47	36	on	on	ADP
can-1768	47	37	particle	particle	NOUN
can-1768	47	38	size	size	NOUN
can-1768	47	39	,	,	PUNCT
can-1768	47	40	distribution	distribution	NOUN
can-1768	47	41	,	,	PUNCT
can-1768	47	42	entrapment	entrapment	ADJ
can-1768	47	43	,	,	PUNCT
can-1768	47	44	and	and	CCONJ
can-1768	47	45	drug	drug	NOUN
can-1768	47	46	loading	loading	NOUN
can-1768	47	47	efficiency	efficiency	NOUN
can-1768	47	48	.	.	PUNCT
can-1768	48	1	these	these	DET
can-1768	48	2	responses	response	NOUN
can-1768	48	3	were	be	AUX
can-1768	48	4	considered	consider	VERB
can-1768	48	5	for	for	ADP
can-1768	48	6	optimization	optimization	NOUN
can-1768	48	7	as	as	SCONJ
can-1768	48	8	they	they	PRON
can-1768	48	9	accounts	account	VERB
can-1768	48	10	very	very	ADV
can-1768	48	11	much	much	ADV
can-1768	48	12	for	for	ADP
can-1768	48	13	rapid	rapid	ADJ
can-1768	48	14	drug	drug	NOUN
can-1768	48	15	absorption	absorption	NOUN
can-1768	48	16	and	and	CCONJ
can-1768	48	17	drug	drug	NOUN
can-1768	48	18	availability	availability	NOUN
can-1768	48	19	.	.	PUNCT
can-1768	49	1	in	in	ADP
can-1768	49	2	order	order	NOUN
can-1768	49	3	to	to	PART
can-1768	49	4	study	study	VERB
can-1768	49	5	the	the	DET
can-1768	49	6	impact	impact	NOUN
can-1768	49	7	of	of	ADP
can-1768	49	8	these	these	DET
can-1768	49	9	three	three	NUM
can-1768	49	10	essential	essential	ADJ
can-1768	49	11	formulation	formulation	NOUN
can-1768	49	12	factors	factor	NOUN
can-1768	49	13	on	on	ADP
can-1768	49	14	particle	particle	NOUN
can-1768	49	15	size	size	NOUN
can-1768	49	16	,	,	PUNCT
can-1768	49	17	entrapment	entrapment	ADJ
can-1768	49	18	efficiency	efficiency	NOUN
can-1768	49	19	,	,	PUNCT
can-1768	49	20	and	and	CCONJ
can-1768	49	21	drug	drug	NOUN
can-1768	49	22	loading	loading	NOUN
can-1768	49	23	efficiency	efficiency	NOUN
can-1768	49	24	,	,	PUNCT
can-1768	49	25	a	a	DET
can-1768	49	26	central	central	ADJ
can-1768	49	27	composite	composite	ADJ
can-1768	49	28	rotatable	rotatable	ADJ
can-1768	49	29	design	design	NOUN
can-1768	49	30	–	–	PUNCT
can-1768	49	31	response	response	NOUN
can-1768	49	32	surface	surface	NOUN
can-1768	49	33	methodology	methodology	NOUN
can-1768	49	34	(	(	PUNCT
can-1768	49	35	ccrd	ccrd	NOUN
can-1768	49	36	–	–	PUNCT
can-1768	49	37	rsm	rsm	PROPN
can-1768	49	38	)	)	PUNCT
can-1768	49	39	was	be	AUX
can-1768	49	40	adopted[19	adopted[19	NOUN
can-1768	49	41	]	]	PUNCT
can-1768	49	42	.	.	PUNCT
can-1768	50	1	table	table	NOUN
can-1768	50	2	1	1	NUM
can-1768	50	3	lists	list	VERB
can-1768	50	4	the	the	DET
can-1768	50	5	design	design	NOUN
can-1768	50	6	specifications	specification	NOUN
can-1768	50	7	.	.	PUNCT
can-1768	51	1	preliminary	preliminary	ADJ
can-1768	51	2	tests	test	NOUN
can-1768	51	3	and	and	CCONJ
can-1768	51	4	the	the	DET
can-1768	51	5	possibility	possibility	NOUN
can-1768	51	6	of	of	ADP
can-1768	51	7	making	make	VERB
can-1768	51	8	nanoparticles	nanoparticle	NOUN
can-1768	51	9	at	at	ADP
can-1768	51	10	extreme	extreme	ADJ
can-1768	51	11	levels	level	NOUN
can-1768	51	12	were	be	AUX
can-1768	51	13	used	use	VERB
can-1768	51	14	to	to	PART
can-1768	51	15	select	select	VERB
can-1768	51	16	the	the	DET
can-1768	51	17	experimental	experimental	ADJ
can-1768	51	18	ranges	range	NOUN
can-1768	51	19	for	for	ADP
can-1768	51	20	each	each	DET
can-1768	51	21	component	component	NOUN
can-1768	51	22	.	.	PUNCT
can-1768	52	1	for	for	ADP
can-1768	52	2	the	the	DET
can-1768	52	3	drug	drug	NOUN
can-1768	52	4	polymer	polymer	NOUN
can-1768	52	5	ratio	ratio	NOUN
can-1768	52	6	(	(	PUNCT
can-1768	52	7	x1	x1	PROPN
can-1768	52	8	)	)	PUNCT
can-1768	52	9	,	,	PUNCT
can-1768	52	10	the	the	DET
can-1768	52	11	range	range	NOUN
can-1768	52	12	was	be	AUX
can-1768	52	13	1:1–1:7	1:1–1:7	ADJ
can-1768	52	14	;	;	PUNCT
can-1768	52	15	for	for	ADP
can-1768	52	16	the	the	DET
can-1768	52	17	aqueous	aqueous	ADJ
can-1768	52	18	-	-	PUNCT
can-1768	52	19	to	to	ADP
can-1768	52	20	-	-	PUNCT
can-1768	52	21	organic	organic	ADJ
can-1768	52	22	phase	phase	NOUN
can-1768	52	23	ratio	ratio	NOUN
can-1768	52	24	(	(	PUNCT
can-1768	52	25	x2	x2	PROPN
can-1768	52	26	)	)	PUNCT
can-1768	52	27	,	,	PUNCT
can-1768	52	28	it	it	PRON
can-1768	52	29	was	be	AUX
can-1768	52	30	1:1–1:5	1:1–1:5	NUM
can-1768	52	31	,	,	PUNCT
can-1768	52	32	and	and	CCONJ
can-1768	52	33	for	for	ADP
can-1768	52	34	the	the	DET
can-1768	52	35	stabilizer	stabilizer	NOUN
can-1768	52	36	concentration	concentration	NOUN
can-1768	52	37	(	(	PUNCT
can-1768	52	38	x3	x3	ADJ
can-1768	52	39	)	)	PUNCT
can-1768	52	40	,	,	PUNCT
can-1768	52	41	it	it	PRON
can-1768	52	42	was	be	AUX
can-1768	52	43	0.1–0.5	0.1–0.5	X
can-1768	52	44	%	%	NOUN
can-1768	52	45	.	.	PUNCT
can-1768	53	1	there	there	PRON
can-1768	53	2	were	be	VERB
can-1768	53	3	a	a	DET
can-1768	53	4	101	101	NUM
can-1768	53	5	total	total	NOUN
can-1768	53	6	of	of	ADP
can-1768	53	7	20	20	NUM
can-1768	53	8	tests	test	NOUN
can-1768	53	9	carried	carry	VERB
can-1768	53	10	out	out	ADP
can-1768	53	11	.	.	PUNCT
can-1768	54	1	in	in	ADP
can-1768	54	2	these	these	DET
can-1768	54	3	tests	test	NOUN
can-1768	54	4	,	,	PUNCT
can-1768	54	5	every	every	DET
can-1768	54	6	formulation	formulation	NOUN
can-1768	54	7	was	be	AUX
can-1768	54	8	made	make	VERB
can-1768	54	9	in	in	ADP
can-1768	54	10	two	two	NUM
can-1768	54	11	separate	separate	ADJ
can-1768	54	12	batches	batch	NOUN
can-1768	54	13	.	.	PUNCT
can-1768	55	1	since	since	SCONJ
can-1768	55	2	it	it	PRON
can-1768	55	3	may	may	AUX
can-1768	55	4	investigate	investigate	VERB
can-1768	55	5	many	many	ADJ
can-1768	55	6	variables	variable	NOUN
can-1768	55	7	at	at	ADP
can-1768	55	8	multiple	multiple	ADJ
can-1768	55	9	levels	level	NOUN
can-1768	55	10	with	with	ADP
can-1768	55	11	a	a	DET
can-1768	55	12	small	small	ADJ
can-1768	55	13	number	number	NOUN
can-1768	55	14	of	of	ADP
can-1768	55	15	tests	test	NOUN
can-1768	55	16	,	,	PUNCT
can-1768	55	17	the	the	DET
can-1768	55	18	central	central	ADJ
can-1768	55	19	composite	composite	ADJ
can-1768	55	20	rotating	rotating	NOUN
can-1768	55	21	design	design	NOUN
can-1768	55	22	–	–	PUNCT
can-1768	55	23	response	response	NOUN
can-1768	55	24	surface	surface	NOUN
can-1768	55	25	methodology	methodology	NOUN
can-1768	55	26	(	(	PUNCT
can-1768	55	27	ccrd	ccrd	NOUN
can-1768	55	28	–	–	PUNCT
can-1768	55	29	rsm	rsm	PROPN
can-1768	55	30	)	)	PUNCT
can-1768	55	31	is	be	AUX
can-1768	55	32	an	an	DET
can-1768	55	33	excellent	excellent	ADJ
can-1768	55	34	alternative	alternative	ADJ
can-1768	55	35	strategy	strategy	NOUN
can-1768	55	36	.	.	PUNCT
can-1768	56	1	after	after	ADP
can-1768	56	2	conducting	conduct	VERB
can-1768	56	3	exploratory	exploratory	ADJ
can-1768	56	4	trials	trial	NOUN
can-1768	56	5	,	,	PUNCT
can-1768	56	6	we	we	PRON
can-1768	56	7	came	come	VERB
can-1768	56	8	up	up	ADP
can-1768	56	9	with	with	ADP
can-1768	56	10	the	the	DET
can-1768	56	11	factors	factor	NOUN
can-1768	56	12	in	in	ADP
can-1768	56	13	table	table	NOUN
can-1768	56	14	1	1	NUM
can-1768	56	15	.	.	PUNCT
can-1768	56	16	particle	particle	NOUN
can-1768	56	17	size	size	NOUN
can-1768	56	18	distribution	distribution	NOUN
can-1768	56	19	,	,	PUNCT
can-1768	56	20	drug	drug	NOUN
can-1768	56	21	loading	loading	NOUN
can-1768	56	22	,	,	PUNCT
can-1768	56	23	and	and	CCONJ
can-1768	56	24	entrapment	entrapment	ADJ
can-1768	56	25	efficiency	efficiency	NOUN
can-1768	56	26	were	be	AUX
can-1768	56	27	all	all	PRON
can-1768	56	28	examined	examine	VERB
can-1768	56	29	in	in	ADP
can-1768	56	30	table	table	NOUN
can-1768	56	31	2	2	NUM
can-1768	56	32	of	of	ADP
can-1768	56	33	the	the	DET
can-1768	56	34	experiments	experiment	NOUN
can-1768	56	35	.	.	PUNCT
can-1768	57	1	94–104	94–104	NUM
can-1768	57	2	nm	nm	PROPN
can-1768	57	3	,	,	PUNCT
can-1768	57	4	75	75	NUM
can-1768	57	5	–	–	SYM
can-1768	57	6	94	94	NUM
can-1768	57	7	%	%	NOUN
can-1768	57	8	,	,	PUNCT
can-1768	57	9	and	and	CCONJ
can-1768	57	10	4–13	4–13	PROPN
can-1768	57	11	%	%	NOUN
can-1768	57	12	were	be	AUX
can-1768	57	13	the	the	DET
can-1768	57	14	three	three	NUM
can-1768	57	15	dependent	dependent	ADJ
can-1768	57	16	variables	variable	NOUN
can-1768	57	17	.	.	PUNCT
can-1768	58	1	design	design	NOUN
can-1768	58	2	-	-	PUNCT
can-1768	58	3	expert	expert	NOUN
can-1768	58	4	®	®	NOUN
can-1768	58	5	7.0	7.0	NUM
can-1768	58	6	software	software	NOUN
can-1768	58	7	was	be	AUX
can-1768	58	8	used	use	VERB
can-1768	58	9	to	to	PART
can-1768	58	10	perform	perform	VERB
can-1768	58	11	response	response	NOUN
can-1768	58	12	surface	surface	NOUN
can-1768	58	13	regression	regression	NOUN
can-1768	58	14	analysis	analysis	NOUN
can-1768	58	15	on	on	ADP
can-1768	58	16	variables	variable	NOUN
can-1768	58	17	and	and	CCONJ
can-1768	58	18	parameters	parameter	NOUN
can-1768	58	19	.	.	PUNCT
can-1768	59	1	table	table	NOUN
can-1768	59	2	1	1	NUM
can-1768	59	3	.	.	PUNCT
can-1768	60	1	independent	independent	ADJ
can-1768	60	2	variables	variable	NOUN
can-1768	60	3	and	and	CCONJ
can-1768	60	4	their	their	PRON
can-1768	60	5	corresponding	corresponding	ADJ
can-1768	60	6	levels	level	NOUN
can-1768	60	7	of	of	ADP
can-1768	60	8	nanoparticle	nanoparticle	NOUN
can-1768	60	9	preparation	preparation	NOUN
can-1768	60	10	for	for	ADP
can-1768	60	11	ccrd	ccrd	PROPN
can-1768	60	12	independent	independent	ADJ
can-1768	60	13	variables	variable	NOUN
can-1768	60	14	levels	level	NOUN
can-1768	60	15	−1	−1	VERB
can-1768	60	16	0	0	PUNCT
can-1768	61	1	+1	+1	ADJ
can-1768	61	2	drug	drug	NOUN
can-1768	61	3	/	/	SYM
can-1768	61	4	polymer	polymer	NOUN
can-1768	61	5	ratio	ratio	NOUN
can-1768	61	6	1:1	1:1	NUM
can-1768	61	7	1:5	1:5	NUM
can-1768	61	8	1:9	1:9	NUM
can-1768	61	9	aqueous	aqueous	ADJ
can-1768	61	10	to	to	ADP
can-1768	61	11	organic	organic	ADJ
can-1768	61	12	phase	phase	NOUN
can-1768	61	13	ratio	ratio	NOUN
can-1768	61	14	1:1	1:1	NUM
can-1768	61	15	1:3.5	1:3.5	NUM
can-1768	61	16	1:6	1:6	NUM
can-1768	61	17	stabilizer	stabilizer	NOUN
can-1768	61	18	concentration	concentration	NOUN
can-1768	61	19	0.1	0.1	NUM
can-1768	61	20	0.55	0.55	NUM
can-1768	61	21	1.0	1.0	NUM
can-1768	61	22	table	table	NOUN
can-1768	61	23	2	2	NUM
can-1768	61	24	.	.	PUNCT
can-1768	61	25	central	central	ADJ
can-1768	61	26	composite	composite	ADJ
can-1768	61	27	design	design	NOUN
can-1768	61	28	consisting	consist	VERB
can-1768	61	29	of	of	ADP
can-1768	61	30	experiments	experiment	NOUN
can-1768	61	31	for	for	ADP
can-1768	61	32	the	the	DET
can-1768	61	33	study	study	NOUN
can-1768	61	34	of	of	ADP
can-1768	61	35	three	three	NUM
can-1768	61	36	experimental	experimental	ADJ
can-1768	61	37	factors	factor	NOUN
can-1768	61	38	in	in	ADP
can-1768	61	39	coded	code	VERB
can-1768	61	40	and	and	CCONJ
can-1768	61	41	actual	actual	ADJ
can-1768	61	42	levels	level	NOUN
can-1768	61	43	with	with	ADP
can-1768	61	44	experimental	experimental	ADJ
can-1768	61	45	results	result	NOUN
can-1768	61	46	s.	s.	PROPN
can-1768	61	47	no	no	DET
can-1768	61	48	trial	trial	NOUN
can-1768	61	49	drug	drug	NOUN
can-1768	61	50	polymer	polymer	NOUN
can-1768	61	51	ratio	ratio	NOUN
can-1768	61	52	aqueous	aqueous	ADJ
can-1768	61	53	organic	organic	ADJ
can-1768	61	54	phase	phase	NOUN
can-1768	61	55	ratio	ratio	NOUN
can-1768	61	56	conc	conc	NOUN
can-1768	61	57	.	.	PUNCT
can-1768	62	1	of	of	ADP
can-1768	62	2	stabilizer	stabilizer	NOUN
can-1768	62	3	particle	particle	NOUN
can-1768	62	4	size	size	NOUN
can-1768	62	5	entrapment	entrapment	NOUN
can-1768	62	6	efficiency	efficiency	NOUN
can-1768	62	7	drug	drug	NOUN
can-1768	62	8	loading	loading	NOUN
can-1768	62	9	1	1	NUM
can-1768	62	10	1	1	NUM
can-1768	62	11	1	1	NUM
can-1768	62	12	1	1	NUM
can-1768	62	13	0.1	0.1	NUM
can-1768	62	14	100.335	100.335	NUM
can-1768	62	15	84.076	84.076	NUM
can-1768	62	16	7.231	7.231	NUM
can-1768	62	17	2	2	NUM
can-1768	62	18	2	2	NUM
can-1768	62	19	9	9	NUM
can-1768	62	20	1	1	NUM
can-1768	62	21	0.1	0.1	NUM
can-1768	62	22	99.3895	99.3895	NUM
can-1768	62	23	83.012	83.012	NUM
can-1768	62	24	8.254	8.254	NUM
can-1768	62	25	3	3	NUM
can-1768	62	26	3	3	NUM
can-1768	62	27	1	1	NUM
can-1768	62	28	6	6	NUM
can-1768	62	29	0.1	0.1	NUM
can-1768	62	30	96.8928	96.8928	NUM
can-1768	62	31	81.123	81.123	NUM
can-1768	62	32	9.014	9.014	NUM
can-1768	62	33	4	4	NUM
can-1768	62	34	4	4	NUM
can-1768	62	35	9	9	NUM
can-1768	62	36	6	6	NUM
can-1768	62	37	0.1	0.1	NUM
can-1768	62	38	96.3544	96.3544	NUM
can-1768	62	39	79.089	79.089	NUM
can-1768	62	40	8.543	8.543	NUM
can-1768	62	41	5	5	NUM
can-1768	62	42	5	5	NUM
can-1768	63	1	1	1	NUM
can-1768	63	2	1	1	NUM
can-1768	63	3	1	1	NUM
can-1768	63	4	97.9656	97.9656	NUM
can-1768	63	5	87.12	87.12	NUM
can-1768	63	6	11.239	11.239	NUM
can-1768	63	7	6	6	NUM
can-1768	63	8	6	6	NUM
can-1768	63	9	9	9	NUM
can-1768	63	10	1	1	NUM
can-1768	63	11	1	1	NUM
can-1768	63	12	95.3729	95.3729	NUM
can-1768	63	13	75.13	75.13	NUM
can-1768	63	14	13.231	13.231	NUM
can-1768	63	15	7	7	NUM
can-1768	63	16	7	7	NUM
can-1768	63	17	1	1	NUM
can-1768	63	18	6	6	NUM
can-1768	63	19	1	1	NUM
can-1768	63	20	103.267	103.267	NUM
can-1768	63	21	85.065	85.065	NUM
can-1768	63	22	10.123	10.123	NUM
can-1768	63	23	8	8	NUM
can-1768	63	24	8	8	NUM
can-1768	63	25	9	9	NUM
can-1768	63	26	6	6	NUM
can-1768	63	27	1	1	NUM
can-1768	63	28	102.642	102.642	NUM
can-1768	63	29	89.87	89.87	NUM
can-1768	63	30	11.435	11.435	NUM
can-1768	63	31	9	9	NUM
can-1768	63	32	9	9	NUM
can-1768	63	33	−1.72717	−1.72717	NOUN
can-1768	63	34	3.5	3.5	NUM
can-1768	63	35	0.55	0.55	NUM
can-1768	63	36	102.176	102.176	NUM
can-1768	63	37	92.1009	92.1009	NUM
can-1768	63	38	5.098	5.098	NUM
can-1768	63	39	10	10	NUM
can-1768	63	40	10	10	NUM
can-1768	63	41	11.7272	11.7272	NUM
can-1768	63	42	3.5	3.5	NUM
can-1768	63	43	0.55	0.55	NUM
can-1768	63	44	104.079	104.079	NUM
can-1768	63	45	79.34	79.34	NUM
can-1768	63	46	11.675	11.675	NUM
can-1768	63	47	11	11	NUM
can-1768	63	48	11	11	NUM
can-1768	63	49	5	5	NUM
can-1768	63	50	−0.704482	−0.704482	NUM
can-1768	63	51	0.55	0.55	NUM
can-1768	63	52	102.726	102.726	NUM
can-1768	63	53	84.012	84.012	NUM
can-1768	63	54	9.233	9.233	NUM
can-1768	63	55	12	12	NUM
can-1768	63	56	12	12	NUM
can-1768	63	57	5	5	NUM
can-1768	63	58	7.70448	7.70448	NUM
can-1768	63	59	0.55	0.55	NUM
can-1768	63	60	94.2578	94.2578	NUM
can-1768	63	61	90.012	90.012	NUM
can-1768	63	62	5.987	5.987	NUM
can-1768	63	63	13	13	NUM
can-1768	63	64	13	13	NUM
can-1768	63	65	5	5	NUM
can-1768	63	66	3.5	3.5	NUM
can-1768	63	67	−0.206807	−0.206807	NUM
can-1768	63	68	96.3522	96.3522	NUM
can-1768	63	69	89.122	89.122	NUM
can-1768	63	70	9.234	9.234	NUM
can-1768	63	71	14	14	NUM
can-1768	63	72	14	14	NUM
can-1768	63	73	5	5	NUM
can-1768	63	74	3.5	3.5	NUM
can-1768	63	75	1.30681	1.30681	NUM
can-1768	63	76	104.532	104.532	NUM
can-1768	63	77	93.9741	93.9741	NUM
can-1768	63	78	5.123	5.123	NUM
can-1768	63	79	15	15	NUM
can-1768	63	80	15	15	NUM
can-1768	63	81	5	5	NUM
can-1768	63	82	3.5	3.5	NUM
can-1768	63	83	0.55	0.55	NUM
can-1768	63	84	98.5098	98.5098	NUM
can-1768	63	85	91.012	91.012	NUM
can-1768	63	86	4.098	4.098	NUM
can-1768	63	87	2.2.1	2.2.1	NUM
can-1768	63	88	particle	particle	NOUN
can-1768	63	89	size	size	NOUN
can-1768	63	90	analysis	analysis	NOUN
can-1768	63	91	a	a	DET
can-1768	63	92	malvern	malvern	ADJ
can-1768	63	93	zetasizer	zetasizer	NOUN
can-1768	63	94	3000	3000	NUM
can-1768	63	95	hsa	hsa	NOUN
can-1768	63	96	was	be	AUX
can-1768	63	97	used	use	VERB
can-1768	63	98	to	to	PART
can-1768	63	99	measure	measure	VERB
can-1768	63	100	particle	particle	NOUN
can-1768	63	101	size	size	NOUN
can-1768	63	102	using	use	VERB
can-1768	63	103	dynamic	dynamic	ADJ
can-1768	63	104	light	light	NOUN
can-1768	63	105	scattering	scattering	NOUN
can-1768	63	106	(	(	PUNCT
can-1768	63	107	dls	dls	PROPN
can-1768	63	108	)	)	PUNCT
can-1768	63	109	(	(	PUNCT
can-1768	63	110	malvern	malvern	PROPN
can-1768	63	111	instruments	instrument	NOUN
can-1768	63	112	,	,	PUNCT
can-1768	63	113	uk	uk	PROPN
can-1768	63	114	)	)	PUNCT
can-1768	63	115	.	.	PUNCT
can-1768	64	1	the	the	DET
can-1768	64	2	polydispersity	polydispersity	NOUN
can-1768	64	3	index	index	NOUN
can-1768	64	4	(	(	PUNCT
can-1768	64	5	pi	pi	NOUN
can-1768	64	6	)	)	PUNCT
can-1768	64	7	,	,	PUNCT
can-1768	64	8	a	a	DET
can-1768	64	9	measure	measure	NOUN
can-1768	64	10	of	of	ADP
can-1768	64	11	the	the	DET
can-1768	64	12	breadth	breadth	NOUN
can-1768	64	13	of	of	ADP
can-1768	64	14	the	the	DET
can-1768	64	15	size	size	NOUN
can-1768	64	16	distribution	distribution	NOUN
can-1768	64	17	,	,	PUNCT
can-1768	64	18	and	and	CCONJ
can-1768	64	19	the	the	DET
can-1768	64	20	mean	mean	ADJ
can-1768	64	21	diameter	diameter	NOUN
can-1768	64	22	are	be	AUX
can-1768	64	23	both	both	PRON
can-1768	64	24	obtained	obtain	VERB
can-1768	64	25	using	use	VERB
can-1768	64	26	dls	dls	PROPN
can-1768	64	27	.	.	PUNCT
can-1768	65	1	temperatures	temperature	NOUN
can-1768	65	2	of	of	ADP
can-1768	65	3	25	25	NUM
can-1768	65	4	°	°	NOUN
can-1768	65	5	c	c	NOUN
can-1768	65	6	were	be	AUX
can-1768	65	7	used	use	VERB
can-1768	65	8	to	to	PART
can-1768	65	9	measure	measure	VERB
can-1768	65	10	the	the	DET
can-1768	65	11	mean	mean	ADJ
can-1768	65	12	diameter	diameter	NOUN
can-1768	65	13	and	and	CCONJ
can-1768	65	14	the	the	DET
can-1768	65	15	proportional	proportional	ADJ
can-1768	65	16	index	index	NOUN
can-1768	65	17	(	(	PUNCT
can-1768	65	18	pi	pi	NOUN
can-1768	65	19	)	)	PUNCT
can-1768	65	20	.	.	PUNCT
can-1768	66	1	an	an	DET
can-1768	66	2	acceptable	acceptable	ADJ
can-1768	66	3	scattering	scattering	NOUN
can-1768	66	4	intensity	intensity	NOUN
can-1768	66	5	was	be	AUX
can-1768	66	6	achieved	achieve	VERB
can-1768	66	7	by	by	ADP
can-1768	66	8	diluting	dilute	VERB
can-1768	66	9	all	all	DET
can-1768	66	10	samples	sample	NOUN
can-1768	66	11	with	with	ADP
can-1768	66	12	double	double	ADJ
can-1768	66	13	-	-	PUNCT
can-1768	66	14	distilled	distil	VERB
can-1768	66	15	water	water	NOUN
can-1768	66	16	prior	prior	ADV
can-1768	66	17	to	to	ADP
can-1768	66	18	testing	testing	NOUN
can-1768	66	19	.	.	PUNCT
can-1768	67	1	2.2.2	2.2.2	NUM
can-1768	67	2	zeta	zeta	PROPN
can-1768	67	3	potential	potential	ADJ
can-1768	67	4	zeta	zeta	NOUN
can-1768	67	5	potential	potential	NOUN
can-1768	67	6	,	,	PUNCT
can-1768	67	7	which	which	PRON
can-1768	67	8	reflects	reflect	VERB
can-1768	67	9	the	the	DET
can-1768	67	10	electric	electric	ADJ
can-1768	67	11	charge	charge	NOUN
can-1768	67	12	on	on	ADP
can-1768	67	13	a	a	DET
can-1768	67	14	particle	particle	NOUN
can-1768	67	15	’s	’s	PART
can-1768	67	16	surface	surface	NOUN
can-1768	67	17	and	and	CCONJ
can-1768	67	18	indicates	indicate	VERB
can-1768	67	19	its	its	PRON
can-1768	67	20	physical	physical	ADJ
can-1768	67	21	stability	stability	NOUN
can-1768	67	22	,	,	PUNCT
can-1768	67	23	was	be	AUX
can-1768	67	24	determined	determine	VERB
can-1768	67	25	by	by	ADP
can-1768	67	26	measuring	measure	VERB
can-1768	67	27	electrophoretic	electrophoretic	ADJ
can-1768	67	28	mobility	mobility	NOUN
can-1768	67	29	using	use	VERB
can-1768	67	30	the	the	DET
can-1768	67	31	malvern	malvern	ADJ
can-1768	67	32	zetasizer	zetasizer	NOUN
can-1768	67	33	3000	3000	NUM
can-1768	67	34	hsa	hsa	NOUN
can-1768	67	35	(	(	PUNCT
can-1768	67	36	figure	figure	NOUN
can-1768	67	37	9	9	NUM
can-1768	67	38	)	)	PUNCT
can-1768	67	39	(	(	PUNCT
can-1768	67	40	malvern	malvern	PROPN
can-1768	67	41	instruments	instrument	NOUN
can-1768	67	42	,	,	PUNCT
can-1768	67	43	uk	uk	PROPN
can-1768	67	44	)	)	PUNCT
can-1768	67	45	.	.	PUNCT
can-1768	68	1	sodium	sodium	NOUN
can-1768	68	2	chloride	chloride	NOUN
can-1768	68	3	solution	solution	NOUN
can-1768	68	4	(	(	PUNCT
can-1768	68	5	0.9	0.9	NUM
can-1768	68	6	%	%	NOUN
can-1768	68	7	w	w	PROPN
can-1768	68	8	/	/	SYM
can-1768	68	9	v	v	NOUN
can-1768	68	10	)	)	PUNCT
can-1768	68	11	was	be	AUX
can-1768	68	12	used	use	VERB
can-1768	68	13	to	to	PART
can-1768	68	14	modify	modify	VERB
can-1768	68	15	the	the	DET
can-1768	68	16	conductivity	conductivity	NOUN
can-1768	68	17	of	of	ADP
can-1768	68	18	the	the	DET
can-1768	68	19	sample	sample	NOUN
can-1768	68	20	to	to	ADP
can-1768	68	21	50	50	NUM
can-1768	68	22	is	be	AUX
can-1768	68	23	/	/	SYM
can-1768	68	24	cm	cm	NOUN
can-1768	68	25	in	in	ADP
can-1768	68	26	double	double	ADJ
can-1768	68	27	distilled	distil	VERB
can-1768	68	28	water	water	NOUN
can-1768	68	29	.	.	PUNCT
can-1768	69	1	the	the	DET
can-1768	69	2	applied	apply	VERB
can-1768	69	3	field	field	NOUN
can-1768	69	4	strength	strength	NOUN
can-1768	69	5	was	be	AUX
can-1768	69	6	20	20	NUM
can-1768	69	7	v	v	NOUN
can-1768	69	8	/	/	SYM
can-1768	69	9	cm	cm	NOUN
can-1768	69	10	and	and	CCONJ
can-1768	69	11	the	the	DET
can-1768	69	12	ph	ph	NOUN
can-1768	69	13	ranged	range	VERB
can-1768	69	14	between	between	ADP
can-1768	69	15	5.5	5.5	NUM
can-1768	69	16	and	and	CCONJ
can-1768	69	17	7.5	7.5	NUM
can-1768	69	18	.	.	PUNCT
can-1768	70	1	2.2.3	2.2.3	NUM
can-1768	70	2	scanning	scan	VERB
can-1768	70	3	electron	electron	NOUN
can-1768	70	4	microscopy	microscopy	NOUN
can-1768	70	5	(	(	PUNCT
can-1768	70	6	sem	sem	NOUN
can-1768	70	7	)	)	PUNCT
can-1768	70	8	measurement	measurement	NOUN
can-1768	70	9	using	use	VERB
can-1768	70	10	a	a	DET
can-1768	70	11	hitachi	hitachi	ADJ
can-1768	70	12	s4800	s4800	NOUN
can-1768	70	13	field	field	NOUN
can-1768	70	14	emission	emission	NOUN
can-1768	70	15	scanning	scan	VERB
can-1768	70	16	electron	electron	NOUN
can-1768	70	17	microscope	microscope	NOUN
can-1768	70	18	(	(	PUNCT
can-1768	70	19	fesem	fesem	NOUN
can-1768	70	20	)	)	PUNCT
can-1768	70	21	,	,	PUNCT
can-1768	70	22	the	the	DET
can-1768	70	23	surface	surface	NOUN
can-1768	70	24	and	and	CCONJ
can-1768	70	25	surface	surface	NOUN
can-1768	70	26	morphology	morphology	NOUN
can-1768	70	27	of	of	ADP
can-1768	70	28	the	the	DET
can-1768	70	29	particles	particle	NOUN
can-1768	70	30	were	be	AUX
can-1768	70	31	analyzed	analyze	VERB
can-1768	70	32	in	in	ADP
can-1768	70	33	detail	detail	NOUN
can-1768	70	34	(	(	PUNCT
can-1768	70	35	hitachi	hitachi	PROPN
can-1768	70	36	,	,	PUNCT
can-1768	70	37	gaithersburg	gaithersburg	PROPN
can-1768	70	38	,	,	PUNCT
can-1768	70	39	102	102	NUM
can-1768	70	40	md	md	PROPN
can-1768	70	41	,	,	PUNCT
can-1768	70	42	usa	usa	PROPN
can-1768	70	43	)	)	PUNCT
can-1768	70	44	.	.	PUNCT
can-1768	71	1	analysis	analysis	NOUN
can-1768	71	2	settings	setting	NOUN
can-1768	71	3	comprised	comprise	VERB
can-1768	71	4	a	a	DET
can-1768	71	5	vacuum	vacuum	NOUN
can-1768	71	6	pressure	pressure	NOUN
can-1768	71	7	of	of	ADP
can-1768	71	8	40	40	NUM
can-1768	71	9	pascals	pascal	NOUN
can-1768	71	10	,	,	PUNCT
can-1768	71	11	an	an	DET
can-1768	71	12	accelerating	accelerate	VERB
can-1768	71	13	voltage	voltage	NOUN
can-1768	71	14	of	of	ADP
can-1768	71	15	10	10	NUM
can-1768	71	16	kev	kev	NOUN
can-1768	71	17	,	,	PUNCT
can-1768	71	18	and	and	CCONJ
can-1768	71	19	a	a	DET
can-1768	71	20	working	work	VERB
can-1768	71	21	distance	distance	NOUN
can-1768	71	22	of	of	ADP
can-1768	71	23	13.5	13.5	NUM
can-1768	71	24	mm	mm	NUM
can-1768	71	25	2.2.4	2.2.4	NUM
can-1768	71	26	differential	differential	NOUN
can-1768	71	27	scanning	scan	VERB
can-1768	71	28	calorimetry	calorimetry	NOUN
can-1768	71	29	(	(	PUNCT
can-1768	71	30	dsc	dsc	NOUN
can-1768	71	31	)	)	PUNCT
can-1768	71	32	analysis	analysis	NOUN
can-1768	71	33	pure	pure	ADJ
can-1768	71	34	cisplatin	cisplatin	NOUN
can-1768	71	35	,	,	PUNCT
can-1768	71	36	plga	plga	NOUN
can-1768	71	37	,	,	PUNCT
can-1768	71	38	physical	physical	ADJ
can-1768	71	39	mixtures	mixture	NOUN
can-1768	71	40	,	,	PUNCT
can-1768	71	41	and	and	CCONJ
can-1768	71	42	cisplatin	cisplatin	NOUN
can-1768	71	43	nanoparticles	nanoparticle	NOUN
can-1768	71	44	were	be	AUX
can-1768	71	45	all	all	PRON
can-1768	71	46	examined	examine	VERB
can-1768	71	47	using	use	VERB
can-1768	71	48	a	a	DET
can-1768	71	49	differential	differential	ADJ
can-1768	71	50	scanning	scan	VERB
can-1768	71	51	calorimeter	calorimeter	NOUN
can-1768	71	52	(	(	PUNCT
can-1768	71	53	dsc	dsc	NOUN
can-1768	71	54	)	)	PUNCT
can-1768	71	55	(	(	PUNCT
can-1768	71	56	shimadzu	shimadzu	PROPN
can-1768	71	57	dsc-60	dsc-60	PROPN
can-1768	71	58	,	,	PUNCT
can-1768	71	59	columbia	columbia	PROPN
can-1768	71	60	,	,	PUNCT
can-1768	71	61	md	md	PROPN
can-1768	71	62	,	,	PUNCT
can-1768	71	63	usa	usa	PROPN
can-1768	71	64	)	)	PUNCT
can-1768	71	65	.	.	PUNCT
can-1768	72	1	it	it	PRON
can-1768	72	2	was	be	AUX
can-1768	72	3	crimped	crimp	VERB
can-1768	72	4	non	non	ADJ
can-1768	72	5	-	-	NOUN
can-1768	72	6	hermetically	hermetically	NOUN
can-1768	72	7	in	in	ADP
can-1768	72	8	an	an	DET
can-1768	72	9	aluminum	aluminum	NOUN
can-1768	72	10	pan	pan	NOUN
can-1768	72	11	and	and	CCONJ
can-1768	72	12	heated	heated	ADJ
can-1768	72	13	at	at	ADP
can-1768	72	14	a	a	DET
can-1768	72	15	rate	rate	NOUN
can-1768	72	16	of	of	ADP
can-1768	72	17	10	10	NUM
can-1768	72	18	°	°	NOUN
can-1768	72	19	c	c	NOUN
can-1768	72	20	/	/	SYM
can-1768	72	21	min	min	NOUN
can-1768	72	22	from	from	ADP
can-1768	72	23	23	23	NUM
can-1768	72	24	°	°	ADP
can-1768	72	25	c	c	NOUN
can-1768	72	26	to	to	ADP
can-1768	72	27	300	300	NUM
can-1768	72	28	°	°	NOUN
can-1768	72	29	c	c	NOUN
can-1768	72	30	under	under	ADP
can-1768	72	31	a	a	DET
can-1768	72	32	nitrogen	nitrogen	NOUN
can-1768	72	33	purge	purge	NOUN
can-1768	72	34	for	for	ADP
can-1768	72	35	dsc	dsc	NOUN
can-1768	72	36	analysis	analysis	NOUN
can-1768	72	37	(	(	PUNCT
can-1768	72	38	3–5	3–5	NUM
can-1768	72	39	mg	mg	NUM
can-1768	72	40	)	)	PUNCT
can-1768	72	41	.	.	PUNCT
can-1768	73	1	2.2.5	2.2.5	NUM
can-1768	73	2	fourier	fourier	NOUN
can-1768	73	3	transform	transform	VERB
can-1768	73	4	infrared	infrared	ADJ
can-1768	73	5	spectroscopy	spectroscopy	NOUN
can-1768	73	6	(	(	PUNCT
can-1768	73	7	ftir	ftir	PROPN
can-1768	73	8	)	)	PUNCT
can-1768	73	9	analysis	analysis	NOUN
can-1768	73	10	ftir	ftir	NOUN
can-1768	73	11	analyses	analysis	NOUN
can-1768	73	12	of	of	ADP
can-1768	73	13	cisplatin	cisplatin	NOUN
can-1768	73	14	,	,	PUNCT
can-1768	73	15	plga	plga	NOUN
can-1768	73	16	,	,	PUNCT
can-1768	73	17	physical	physical	ADJ
can-1768	73	18	mixture	mixture	NOUN
can-1768	73	19	and	and	CCONJ
can-1768	73	20	cisplatin	cisplatin	NOUN
can-1768	73	21	nanoparticles	nanoparticle	NOUN
can-1768	73	22	were	be	AUX
can-1768	73	23	carried	carry	VERB
can-1768	73	24	out	out	ADP
can-1768	73	25	using	use	VERB
can-1768	73	26	ir	ir	PROPN
can-1768	73	27	prestige-21	prestige-21	PROPN
can-1768	73	28	(	(	PUNCT
can-1768	73	29	shimadzu	shimadzu	PROPN
can-1768	73	30	,	,	PUNCT
can-1768	73	31	columbia	columbia	PROPN
can-1768	73	32	,	,	PUNCT
can-1768	73	33	md	md	PROPN
can-1768	73	34	,	,	PUNCT
can-1768	73	35	usa	usa	PROPN
can-1768	73	36	)	)	PUNCT
can-1768	73	37	.	.	PUNCT
can-1768	74	1	the	the	DET
can-1768	74	2	sample	sample	NOUN
can-1768	74	3	was	be	AUX
can-1768	74	4	placed	place	VERB
can-1768	74	5	in	in	ADP
can-1768	74	6	direct	direct	ADJ
can-1768	74	7	contact	contact	NOUN
can-1768	74	8	with	with	ADP
can-1768	74	9	atr	atr	PROPN
can-1768	74	10	crystal	crystal	PROPN
can-1768	74	11	ensuring	ensure	VERB
can-1768	74	12	good	good	ADJ
can-1768	74	13	contact	contact	NOUN
can-1768	74	14	.	.	PUNCT
can-1768	75	1	all	all	DET
can-1768	75	2	the	the	DET
can-1768	75	3	spectra	spectra	NOUN
can-1768	75	4	were	be	AUX
can-1768	75	5	recorded	record	VERB
can-1768	75	6	as	as	ADP
can-1768	75	7	a	a	DET
can-1768	75	8	mean	mean	NOUN
can-1768	75	9	of	of	ADP
can-1768	75	10	20	20	NUM
can-1768	75	11	scans	scan	NOUN
can-1768	75	12	,	,	PUNCT
can-1768	75	13	with	with	ADP
can-1768	75	14	a	a	DET
can-1768	75	15	resolution	resolution	NOUN
can-1768	75	16	of	of	ADP
can-1768	75	17	4	4	NUM
can-1768	75	18	cm−1	cm−1	NOUN
can-1768	75	19	and	and	CCONJ
can-1768	75	20	in	in	ADP
can-1768	75	21	the	the	DET
can-1768	75	22	range	range	NOUN
can-1768	75	23	of	of	ADP
can-1768	75	24	800	800	NUM
can-1768	75	25	to	to	PART
can-1768	75	26	4,000	4,000	NUM
can-1768	75	27	cm−1	cm−1	NOUN
can-1768	75	28	.	.	PUNCT
can-1768	76	1	2.2.6	2.2.6	NUM
can-1768	76	2	chromatographic	chromatographic	ADJ
can-1768	76	3	conditions	condition	NOUN
can-1768	76	4	chromolith	chromolith	VERB
can-1768	76	5	rp-18e	rp-18e	NOUN
can-1768	76	6	(	(	PUNCT
can-1768	76	7	e	e	NOUN
can-1768	76	8	-	-	NOUN
can-1768	76	9	merk	merk	NOUN
can-1768	76	10	,	,	PUNCT
can-1768	76	11	4.6	4.6	NUM
can-1768	76	12	×	×	NOUN
can-1768	76	13	50	50	NUM
can-1768	76	14	mm	mm	NOUN
can-1768	76	15	)	)	PUNCT
can-1768	76	16	column	column	NOUN
can-1768	76	17	was	be	AUX
can-1768	76	18	used	use	VERB
can-1768	76	19	to	to	PART
can-1768	76	20	measure	measure	VERB
can-1768	76	21	the	the	DET
can-1768	76	22	cisplatin	cisplatin	NOUN
can-1768	76	23	concentration	concentration	NOUN
can-1768	76	24	in	in	ADP
can-1768	76	25	the	the	DET
can-1768	76	26	hplc	hplc	NOUN
can-1768	76	27	system[20	system[20	NOUN
can-1768	76	28	]	]	PUNCT
can-1768	76	29	.	.	PUNCT
can-1768	77	1	an	an	DET
can-1768	77	2	acetonitrile	acetonitrile	ADJ
can-1768	77	3	-	-	PUNCT
can-1768	77	4	water	water	NOUN
can-1768	77	5	mixture	mixture	NOUN
can-1768	77	6	containing	contain	VERB
can-1768	77	7	0.1	0.1	NUM
can-1768	77	8	%	%	NOUN
can-1768	77	9	formic	formic	ADJ
can-1768	77	10	acid	acid	NOUN
can-1768	77	11	(	(	PUNCT
can-1768	77	12	40:60	40:60	NUM
can-1768	77	13	)	)	PUNCT
can-1768	77	14	was	be	AUX
can-1768	77	15	utilized	utilize	VERB
can-1768	77	16	as	as	ADP
can-1768	77	17	the	the	DET
can-1768	77	18	mobile	mobile	ADJ
can-1768	77	19	phase	phase	NOUN
can-1768	77	20	.	.	PUNCT
can-1768	78	1	a	a	DET
can-1768	78	2	flow	flow	NOUN
can-1768	78	3	rate	rate	NOUN
can-1768	78	4	of	of	ADP
can-1768	78	5	0.5	0.5	NUM
can-1768	78	6	ml	ml	NOUN
can-1768	78	7	/	/	SYM
can-1768	78	8	min	min	NOUN
can-1768	78	9	was	be	AUX
can-1768	78	10	measured	measure	VERB
can-1768	78	11	.	.	PUNCT
can-1768	79	1	10	10	NUM
can-1768	79	2	µl	µl	NOUN
can-1768	79	3	of	of	ADP
can-1768	79	4	injection	injection	NOUN
can-1768	79	5	was	be	AUX
can-1768	79	6	used	use	VERB
can-1768	79	7	with	with	ADP
can-1768	79	8	a	a	DET
can-1768	79	9	490	490	NUM
can-1768	79	10	nm	nm	ADJ
can-1768	79	11	laser	laser	NOUN
can-1768	79	12	and	and	CCONJ
can-1768	79	13	a	a	DET
can-1768	79	14	wavelength	wavelength	NOUN
can-1768	79	15	of	of	ADP
can-1768	79	16	10	10	NUM
can-1768	79	17	nm	nm	NOUN
can-1768	79	18	.	.	PUNCT
can-1768	80	1	2.2.7	2.2.7	NUM
can-1768	80	2	determination	determination	NOUN
can-1768	80	3	of	of	ADP
can-1768	80	4	drug	drug	NOUN
can-1768	80	5	entrapment	entrapment	NOUN
can-1768	80	6	efficiency	efficiency	NOUN
can-1768	80	7	(	(	PUNCT
can-1768	80	8	ee	ee	PROPN
can-1768	80	9	)	)	PUNCT
can-1768	80	10	and	and	CCONJ
can-1768	80	11	drug	drug	NOUN
can-1768	80	12	loading	loading	NOUN
can-1768	80	13	(	(	PUNCT
can-1768	80	14	dl	dl	NOUN
can-1768	80	15	)	)	PUNCT
can-1768	80	16	centrifuged	centrifuged	ADJ
can-1768	80	17	nanoformulations	nanoformulation	NOUN
can-1768	80	18	were	be	AUX
can-1768	80	19	evaluated	evaluate	VERB
can-1768	80	20	by	by	ADP
can-1768	80	21	hplc[21	hplc[21	PROPN
can-1768	80	22	]	]	X
can-1768	80	23	,	,	PUNCT
can-1768	80	24	and	and	CCONJ
can-1768	80	25	the	the	DET
can-1768	80	26	supernatant	supernatant	NOUN
can-1768	80	27	containing	contain	VERB
can-1768	80	28	the	the	DET
can-1768	80	29	free	free	ADJ
can-1768	80	30	drug	drug	NOUN
can-1768	80	31	,	,	PUNCT
can-1768	80	32	which	which	PRON
can-1768	80	33	was	be	AUX
can-1768	80	34	recovered	recover	VERB
can-1768	80	35	,	,	PUNCT
can-1768	80	36	was	be	AUX
can-1768	80	37	further	far	ADV
can-1768	80	38	studied	study	VERB
can-1768	80	39	.	.	PUNCT
can-1768	81	1	unentrapped	unentrappe	VERB
can-1768	81	2	nanoparticles	nanoparticle	NOUN
can-1768	81	3	of	of	ADP
can-1768	81	4	drug	drug	NOUN
can-1768	81	5	may	may	AUX
can-1768	81	6	be	be	AUX
can-1768	81	7	determined	determine	VERB
can-1768	81	8	using	use	VERB
can-1768	81	9	this	this	DET
can-1768	81	10	method	method	NOUN
can-1768	81	11	.	.	PUNCT
can-1768	82	1	in	in	ADP
can-1768	82	2	order	order	NOUN
can-1768	82	3	to	to	PART
can-1768	82	4	determine	determine	VERB
can-1768	82	5	the	the	DET
can-1768	82	6	amount	amount	NOUN
can-1768	82	7	of	of	ADP
can-1768	82	8	drug	drug	NOUN
can-1768	82	9	encapsulated	encapsulate	VERB
can-1768	82	10	in	in	ADP
can-1768	82	11	nanoparticles	nanoparticle	NOUN
can-1768	82	12	,	,	PUNCT
can-1768	82	13	a	a	DET
can-1768	82	14	subtraction	subtraction	NOUN
can-1768	82	15	was	be	AUX
can-1768	82	16	made	make	VERB
can-1768	82	17	from	from	ADP
can-1768	82	18	the	the	DET
can-1768	82	19	total	total	ADJ
can-1768	82	20	amount	amount	NOUN
can-1768	82	21	of	of	ADP
can-1768	82	22	drug	drug	NOUN
can-1768	82	23	added	add	VERB
can-1768	82	24	to	to	ADP
can-1768	82	25	the	the	DET
can-1768	82	26	formulation	formulation	NOUN
can-1768	82	27	.	.	PUNCT
can-1768	83	1	for	for	ADP
can-1768	83	2	the	the	DET
can-1768	83	3	evaluation	evaluation	NOUN
can-1768	83	4	of	of	ADP
can-1768	83	5	the	the	DET
can-1768	83	6	formulations	formulation	NOUN
can-1768	83	7	,	,	PUNCT
can-1768	83	8	the	the	DET
can-1768	83	9	following	follow	VERB
can-1768	83	10	formula	formula	NOUN
can-1768	83	11	was	be	AUX
can-1768	83	12	used	use	VERB
can-1768	83	13	:	:	PUNCT
can-1768	84	1	𝐸𝐸𝐸𝐸	𝐸𝐸𝐸𝐸	PROPN
can-1768	84	2	=	=	PRON
can-1768	84	3	𝐴𝐴𝐴𝐴𝐴𝐴𝐴𝐴𝐴𝐴𝐴𝐴	𝐴𝐴𝐴𝐴𝐴𝐴𝐴𝐴𝐴𝐴𝐴𝐴	PROPN
can-1768	84	4	𝐴𝐴𝑜𝑜	𝐴𝐴𝑜𝑜	NOUN
can-1768	84	5	𝑑𝑑𝑑𝑑𝐴𝐴𝑑𝑑	𝑑𝑑𝑑𝑑𝐴𝐴𝑑𝑑	VERB
can-1768	84	6	𝑖𝑖𝐴𝐴	𝑖𝑖𝐴𝐴	NUM
can-1768	84	7	𝐴𝐴𝑛𝑛𝐴𝐴𝐴𝐴𝑛𝑛𝑛𝑛𝑑𝑑𝐴𝐴𝑖𝑖𝑛𝑛𝑛𝑛𝑛𝑛	𝐴𝐴𝑛𝑛𝐴𝐴𝐴𝐴𝑛𝑛𝑛𝑛𝑑𝑑𝐴𝐴𝑖𝑖𝑛𝑛𝑛𝑛𝑛𝑛	ADJ
can-1768	84	8	𝐴𝐴𝐴𝐴𝐴𝐴𝐴𝐴𝐴𝐴𝐴𝐴	𝐴𝐴𝐴𝐴𝐴𝐴𝐴𝐴𝐴𝐴𝐴𝐴	PROPN
can-1768	84	9	𝐴𝐴𝑜𝑜	𝐴𝐴𝑜𝑜	PROPN
can-1768	84	10	𝑑𝑑𝑑𝑑𝐴𝐴𝑑𝑑	𝑑𝑑𝑑𝑑𝐴𝐴𝑑𝑑	VERB
can-1768	84	11	−	−	PROPN
can-1768	84	12	𝐿𝐿𝐴𝐴𝑛𝑛𝑑𝑑𝑛𝑛𝑑𝑑	𝐿𝐿𝐴𝐴𝑛𝑛𝑑𝑑𝑛𝑛𝑑𝑑	PROPN
can-1768	84	13	𝐴𝐴𝑛𝑛𝐴𝐴𝐴𝐴𝑛𝑛𝑛𝑛𝑑𝑑𝐴𝐴𝑖𝑖𝑛𝑛𝑛𝑛𝑛𝑛	𝐴𝐴𝑛𝑛𝐴𝐴𝐴𝐴𝑛𝑛𝑛𝑛𝑑𝑑𝐴𝐴𝑖𝑖𝑛𝑛𝑛𝑛𝑛𝑛	NOUN
can-1768	84	14	×	×	PROPN
can-1768	84	15	100	100	NUM
can-1768	84	16	𝐷𝐷𝐿𝐿	𝐷𝐷𝐿𝐿	PROPN
can-1768	84	17	=	=	PUNCT
can-1768	84	18	𝐴𝐴𝐴𝐴𝐴𝐴𝐴𝐴𝐴𝐴𝐴𝐴	𝐴𝐴𝐴𝐴𝐴𝐴𝐴𝐴𝐴𝐴𝐴𝐴	PROPN
can-1768	84	19	𝐴𝐴𝑜𝑜	𝐴𝐴𝑜𝑜	NOUN
can-1768	84	20	𝑑𝑑𝑑𝑑𝐴𝐴𝑑𝑑	𝑑𝑑𝑑𝑑𝐴𝐴𝑑𝑑	VERB
can-1768	84	21	𝑖𝑖𝐴𝐴	𝑖𝑖𝐴𝐴	NUM
can-1768	84	22	𝐴𝐴𝑛𝑛𝐴𝐴𝐴𝐴𝑛𝑛𝑛𝑛𝑑𝑑𝐴𝐴𝑖𝑖𝑛𝑛𝑛𝑛𝑛𝑛	𝐴𝐴𝑛𝑛𝐴𝐴𝐴𝐴𝑛𝑛𝑛𝑛𝑑𝑑𝐴𝐴𝑖𝑖𝑛𝑛𝑛𝑛𝑛𝑛	ADJ
can-1768	84	23	𝐴𝐴𝐴𝐴𝐴𝐴𝐴𝐴𝐴𝐴𝐴𝐴	𝐴𝐴𝐴𝐴𝐴𝐴𝐴𝐴𝐴𝐴𝐴𝐴	PROPN
can-1768	84	24	𝐴𝐴𝑜𝑜	𝐴𝐴𝑜𝑜	PROPN
can-1768	84	25	𝑑𝑑𝑑𝑑𝐴𝐴𝑑𝑑	𝑑𝑑𝑑𝑑𝐴𝐴𝑑𝑑	NOUN
can-1768	84	26	𝑜𝑜𝐴𝐴𝑑𝑑	𝑜𝑜𝐴𝐴𝑑𝑑	PUNCT
can-1768	84	27	𝑛𝑛𝐴𝐴𝑛𝑛𝑑𝑑𝑖𝑖𝐴𝐴𝑑𝑑	𝑛𝑛𝐴𝐴𝑛𝑛𝑑𝑑𝑖𝑖𝐴𝐴𝑑𝑑	PRON
can-1768	84	28	×	×	PROPN
can-1768	84	29	100	100	NUM
can-1768	84	30	2.2.8	2.2.8	NUM
can-1768	84	31	in	in	ADP
can-1768	84	32	vitro	vitro	X
can-1768	84	33	release	release	NOUN
can-1768	84	34	study	study	NOUN
can-1768	84	35	dialysis	dialysis	NOUN
can-1768	84	36	bags	bag	NOUN
can-1768	84	37	(	(	PUNCT
can-1768	84	38	cellulose	cellulose	NOUN
can-1768	84	39	membrane	membrane	NOUN
can-1768	84	40	,	,	PUNCT
can-1768	84	41	12400mw	12400mw	NOUN
can-1768	84	42	,	,	PUNCT
can-1768	84	43	sigma	sigma	PROPN
can-1768	84	44	)	)	PUNCT
can-1768	84	45	were	be	AUX
can-1768	84	46	used	use	VERB
can-1768	84	47	to	to	PART
can-1768	84	48	contain	contain	VERB
can-1768	84	49	nanoparticle	nanoparticle	NOUN
can-1768	84	50	samples	sample	NOUN
can-1768	84	51	,	,	PUNCT
can-1768	84	52	which	which	PRON
can-1768	84	53	were	be	AUX
can-1768	84	54	incubated	incubate	VERB
can-1768	84	55	in	in	ADP
can-1768	84	56	30	30	NUM
can-1768	84	57	ml	ml	NOUN
can-1768	84	58	of	of	ADP
can-1768	84	59	pbs	pbs	PROPN
can-1768	84	60	(	(	PUNCT
can-1768	84	61	ph	ph	NOUN
can-1768	84	62	7.4	7.4	NUM
can-1768	84	63	)	)	PUNCT
can-1768	84	64	at	at	ADP
can-1768	84	65	37	37	NUM
can-1768	84	66	°	°	NOUN
can-1768	84	67	c	c	NOUN
can-1768	84	68	under	under	ADP
can-1768	84	69	gentle	gentle	ADJ
can-1768	84	70	agitation	agitation	NOUN
can-1768	84	71	in	in	ADP
can-1768	84	72	a	a	DET
can-1768	84	73	water	water	NOUN
can-1768	84	74	bath	bath	NOUN
can-1768	84	75	at	at	ADP
can-1768	84	76	37	37	NUM
can-1768	84	77	°	°	NOUN
can-1768	84	78	c	c	X
can-1768	84	79	(	(	PUNCT
can-1768	84	80	20	20	NUM
can-1768	84	81	)	)	PUNCT
can-1768	84	82	.	.	PUNCT
can-1768	85	1	samples	sample	NOUN
can-1768	85	2	were	be	AUX
can-1768	85	3	taken	take	VERB
can-1768	85	4	from	from	ADP
can-1768	85	5	the	the	DET
can-1768	85	6	incubation	incubation	NOUN
can-1768	85	7	mixture	mixture	NOUN
can-1768	85	8	at	at	ADP
can-1768	85	9	predefined	predefine	VERB
can-1768	85	10	intervals	interval	NOUN
can-1768	85	11	and	and	CCONJ
can-1768	85	12	tested	test	VERB
can-1768	85	13	for	for	ADP
can-1768	85	14	cisplatin	cisplatin	NOUN
can-1768	85	15	using	use	VERB
can-1768	85	16	the	the	DET
can-1768	85	17	hplc	hplc	NOUN
can-1768	85	18	technique	technique	NOUN
can-1768	85	19	as	as	SCONJ
can-1768	85	20	described	describe	VERB
can-1768	85	21	above	above	ADV
can-1768	85	22	.	.	PUNCT
can-1768	86	1	every	every	DET
can-1768	86	2	time	time	NOUN
can-1768	86	3	a	a	DET
can-1768	86	4	sample	sample	NOUN
can-1768	86	5	was	be	AUX
can-1768	86	6	taken	take	VERB
can-1768	86	7	,	,	PUNCT
can-1768	86	8	the	the	DET
can-1768	86	9	incubation	incubation	NOUN
can-1768	86	10	media	medium	NOUN
can-1768	86	11	was	be	AUX
can-1768	86	12	changed	change	VERB
can-1768	86	13	with	with	ADP
can-1768	86	14	new	new	ADJ
can-1768	86	15	pbs	pbs	PROPN
can-1768	86	16	.	.	PUNCT
can-1768	87	1	in	in	ADP
can-1768	87	2	addition	addition	NOUN
can-1768	87	3	,	,	PUNCT
can-1768	87	4	a	a	DET
can-1768	87	5	control	control	NOUN
can-1768	87	6	experiment	experiment	NOUN
can-1768	87	7	was	be	AUX
can-1768	87	8	conducted	conduct	VERB
can-1768	87	9	to	to	PART
can-1768	87	10	assess	assess	VERB
can-1768	87	11	the	the	DET
can-1768	87	12	free	free	ADJ
can-1768	87	13	drug	drug	NOUN
can-1768	87	14	’s	’s	PART
can-1768	87	15	release	release	NOUN
can-1768	87	16	behavior	behavior	NOUN
can-1768	87	17	.	.	PUNCT
can-1768	88	1	dialysis	dialysis	NOUN
can-1768	88	2	bags	bag	NOUN
can-1768	88	3	were	be	AUX
can-1768	88	4	filled	fill	VERB
can-1768	88	5	with	with	ADP
can-1768	88	6	pbs	pbs	PROPN
can-1768	88	7	,	,	PUNCT
can-1768	88	8	pbs	pbs	PROPN
can-1768	88	9	at	at	ADP
can-1768	88	10	37	37	NUM
can-1768	88	11	°	°	NOUN
can-1768	88	12	c	c	NOUN
can-1768	88	13	,	,	PUNCT
can-1768	88	14	and	and	CCONJ
can-1768	88	15	dissolved	dissolve	VERB
can-1768	88	16	cisplatin	cisplatin	NOUN
can-1768	88	17	in	in	ADP
can-1768	88	18	1	1	NUM
can-1768	88	19	ml	ml	NOUN
can-1768	88	20	of	of	ADP
can-1768	88	21	this	this	DET
can-1768	88	22	solution	solution	NOUN
can-1768	88	23	,	,	PUNCT
can-1768	88	24	which	which	PRON
can-1768	88	25	was	be	AUX
can-1768	88	26	deposited	deposit	VERB
can-1768	88	27	in	in	ADP
can-1768	88	28	30	30	NUM
can-1768	88	29	ml	ml	NOUN
can-1768	88	30	of	of	ADP
can-1768	88	31	pbs	pbs	PROPN
can-1768	88	32	.	.	PUNCT
can-1768	89	1	it	it	PRON
can-1768	89	2	was	be	AUX
can-1768	89	3	determined	determine	VERB
can-1768	89	4	that	that	SCONJ
can-1768	89	5	cisplatin	cisplatin	NOUN
can-1768	89	6	was	be	AUX
can-1768	89	7	released	release	VERB
can-1768	89	8	in	in	ADP
can-1768	89	9	the	the	DET
can-1768	89	10	manner	manner	NOUN
can-1768	89	11	stated	state	VERB
can-1768	89	12	above	above	ADV
can-1768	89	13	.	.	PUNCT
can-1768	90	1	2.3	2.3	NUM
can-1768	90	2	data	datum	NOUN
can-1768	90	3	analysis	analysis	NOUN
can-1768	90	4	design	design	NOUN
can-1768	90	5	-	-	PUNCT
can-1768	90	6	expert	expert	NOUN
can-1768	90	7	®	®	NOUN
can-1768	90	8	software	software	NOUN
can-1768	90	9	was	be	AUX
can-1768	90	10	used	use	VERB
can-1768	90	11	to	to	PART
can-1768	90	12	analyze	analyze	VERB
can-1768	90	13	the	the	DET
can-1768	90	14	connections	connection	NOUN
can-1768	90	15	between	between	ADP
can-1768	90	16	model	model	NOUN
can-1768	90	17	responses	response	NOUN
can-1768	90	18	and	and	CCONJ
can-1768	90	19	their	their	PRON
can-1768	90	20	corresponding	correspond	VERB
can-1768	90	21	formulation	formulation	NOUN
can-1768	90	22	factors	factor	NOUN
can-1768	90	23	.	.	PUNCT
can-1768	91	1	stepwise	stepwise	PROPN
can-1768	91	2	linear	linear	PROPN
can-1768	91	3	regression	regression	PROPN
can-1768	91	4	and	and	CCONJ
can-1768	91	5	response	response	NOUN
can-1768	91	6	surface	surface	NOUN
can-1768	91	7	analysis	analysis	NOUN
can-1768	91	8	were	be	AUX
can-1768	91	9	used	use	VERB
can-1768	91	10	in	in	ADP
can-1768	91	11	the	the	DET
can-1768	91	12	statistical	statistical	ADJ
can-1768	91	13	study	study	NOUN
can-1768	91	14	.	.	PUNCT
can-1768	92	1	in	in	ADP
can-1768	92	2	the	the	DET
can-1768	92	3	final	final	ADJ
can-1768	92	4	equations	equation	NOUN
can-1768	92	5	,	,	PUNCT
can-1768	92	6	only	only	ADV
can-1768	92	7	significant	significant	ADJ
can-1768	92	8	terms	term	NOUN
can-1768	92	9	(	(	PUNCT
can-1768	92	10	p	p	X
can-1768	92	11	<	<	X
can-1768	92	12	0.05	0.05	NUM
can-1768	92	13	)	)	PUNCT
can-1768	92	14	were	be	AUX
can-1768	92	15	used	use	VERB
can-1768	92	16	.	.	PUNCT
can-1768	93	1	linear	linear	ADJ
can-1768	93	2	,	,	PUNCT
can-1768	93	3	quadratic	quadratic	ADJ
can-1768	93	4	,	,	PUNCT
can-1768	93	5	and	and	CCONJ
can-1768	93	6	special	special	ADJ
can-1768	93	7	cubic	cubic	ADJ
can-1768	93	8	models	model	NOUN
can-1768	93	9	are	be	AUX
can-1768	93	10	all	all	ADV
can-1768	93	11	suitable	suitable	ADJ
can-1768	93	12	for	for	ADP
can-1768	93	13	three	three	NUM
can-1768	93	14	-	-	PUNCT
can-1768	93	15	component	component	NOUN
can-1768	93	16	models	model	NOUN
can-1768	93	17	.	.	PUNCT
can-1768	94	1	on	on	ADP
can-1768	94	2	the	the	DET
can-1768	94	3	basis	basis	NOUN
can-1768	94	4	of	of	ADP
can-1768	94	5	statistical	statistical	ADJ
can-1768	94	6	comparisons	comparison	NOUN
can-1768	94	7	of	of	ADP
can-1768	94	8	a	a	DET
can-1768	94	9	number	number	NOUN
can-1768	94	10	of	of	ADP
can-1768	94	11	statistical	statistical	ADJ
can-1768	94	12	parameters	parameter	NOUN
can-1768	94	13	,	,	PUNCT
can-1768	94	14	including	include	VERB
can-1768	94	15	the	the	DET
can-1768	94	16	coefficient	coefficient	NOUN
can-1768	94	17	of	of	ADP
can-1768	94	18	variation	variation	NOUN
can-1768	94	19	(	(	PUNCT
can-1768	94	20	cv	cv	PROPN
can-1768	94	21	)	)	PUNCT
can-1768	94	22	,	,	PUNCT
can-1768	94	23	the	the	DET
can-1768	94	24	multiple	multiple	ADJ
can-1768	94	25	correlation	correlation	NOUN
can-1768	94	26	coefficient	coefficient	NOUN
can-1768	94	27	(	(	PUNCT
can-1768	94	28	r2	r2	PROPN
can-1768	94	29	)	)	PUNCT
can-1768	94	30	,	,	PUNCT
can-1768	94	31	and	and	CCONJ
can-1768	94	32	an	an	DET
can-1768	94	33	adjusted	adjust	VERB
can-1768	94	34	multiple	multiple	ADJ
can-1768	94	35	correlation	correlation	NOUN
can-1768	94	36	coefficient	coefficient	NOUN
can-1768	94	37	(	(	PUNCT
can-1768	94	38	adjusted	adjusted	ADJ
can-1768	94	39	r2	r2	NOUN
can-1768	94	40	)	)	PUNCT
can-1768	94	41	proved	prove	VERB
can-1768	94	42	by	by	ADP
can-1768	94	43	design	design	NOUN
can-1768	94	44	-	-	PUNCT
can-1768	94	45	expert	expert	NOUN
can-1768	94	46	software	software	NOUN
can-1768	94	47	,	,	PUNCT
can-1768	94	48	the	the	DET
can-1768	94	49	best	well	ADV
can-1768	94	50	fitting	fitting	ADJ
can-1768	94	51	mathematical	mathematical	ADJ
can-1768	94	52	model	model	NOUN
can-1768	94	53	was	be	AUX
can-1768	94	54	selected	select	VERB
can-1768	94	55	.	.	PUNCT
can-1768	95	1	student	student	NOUN
can-1768	95	2	’s	’s	PART
can-1768	95	3	t	t	PROPN
can-1768	95	4	-	-	PUNCT
can-1768	95	5	test	test	NOUN
can-1768	95	6	and	and	CCONJ
can-1768	95	7	one	one	NUM
can-1768	95	8	-	-	PUNCT
can-1768	95	9	way	way	NOUN
can-1768	95	10	anova	anova	PROPN
can-1768	95	11	were	be	AUX
can-1768	95	12	used	use	VERB
can-1768	95	13	to	to	PART
can-1768	95	14	determine	determine	VERB
can-1768	95	15	the	the	DET
can-1768	95	16	significance	significance	NOUN
can-1768	95	17	of	of	ADP
can-1768	95	18	differences	difference	NOUN
can-1768	95	19	at	at	ADP
can-1768	95	20	a	a	DET
can-1768	95	21	0.05	0.05	NUM
can-1768	95	22	significance	significance	NOUN
can-1768	95	23	level	level	NOUN
can-1768	95	24	.	.	PUNCT
can-1768	96	1	103	103	NUM
can-1768	96	2	3	3	NUM
can-1768	96	3	.	.	PUNCT
can-1768	96	4	results	result	NOUN
can-1768	96	5	and	and	CCONJ
can-1768	96	6	discussion	discussion	NOUN
can-1768	96	7	3.1	3.1	NUM
can-1768	96	8	optimization	optimization	NOUN
can-1768	96	9	of	of	ADP
can-1768	96	10	formulas	formula	NOUN
can-1768	96	11	according	accord	VERB
can-1768	96	12	to	to	ADP
can-1768	96	13	the	the	DET
can-1768	96	14	most	most	ADV
can-1768	96	15	statistically	statistically	ADV
can-1768	96	16	significant	significant	ADJ
can-1768	96	17	factors	factor	NOUN
can-1768	96	18	on	on	ADP
can-1768	96	19	the	the	DET
can-1768	96	20	examined	examine	VERB
can-1768	96	21	parameters	parameter	NOUN
can-1768	96	22	,	,	PUNCT
can-1768	96	23	3d	3d	NUM
can-1768	96	24	response	response	NOUN
can-1768	96	25	surface	surface	NOUN
can-1768	96	26	graphs	graph	NOUN
can-1768	96	27	are	be	AUX
can-1768	96	28	provided	provide	VERB
can-1768	96	29	in	in	ADP
can-1768	96	30	figures	figure	NOUN
can-1768	96	31	1–3	1–3	NUM
can-1768	96	32	.	.	PUNCT
can-1768	97	1	the	the	DET
can-1768	97	2	experiment	experiment	NOUN
can-1768	97	3	yielded	yield	VERB
can-1768	97	4	a	a	DET
can-1768	97	5	desirability	desirability	NOUN
can-1768	97	6	of	of	ADP
can-1768	97	7	0.542	0.542	NUM
can-1768	97	8	(	(	PUNCT
can-1768	97	9	figure	figure	NOUN
can-1768	97	10	4	4	NUM
can-1768	97	11	)	)	PUNCT
can-1768	97	12	.	.	PUNCT
can-1768	98	1	particle	particle	NOUN
can-1768	98	2	size	size	NOUN
can-1768	98	3	and	and	CCONJ
can-1768	98	4	entrapment	entrapment	ADJ
can-1768	98	5	efficiency	efficiency	NOUN
can-1768	98	6	improve	improve	VERB
can-1768	98	7	with	with	ADP
can-1768	98	8	a	a	DET
can-1768	98	9	rise	rise	NOUN
can-1768	98	10	in	in	ADP
can-1768	98	11	polymer	polymer	NOUN
can-1768	98	12	content	content	NOUN
can-1768	98	13	and	and	CCONJ
can-1768	98	14	the	the	DET
can-1768	98	15	aqueous	aqueous	ADJ
can-1768	98	16	to	to	ADP
can-1768	98	17	organic	organic	ADJ
can-1768	98	18	phase	phase	NOUN
can-1768	98	19	ratio	ratio	NOUN
can-1768	98	20	.	.	PUNCT
can-1768	99	1	polymer	polymer	NOUN
can-1768	99	2	concentration	concentration	NOUN
can-1768	99	3	and	and	CCONJ
can-1768	99	4	aqueous	aqueous	ADJ
can-1768	99	5	to	to	ADP
can-1768	99	6	organic	organic	ADJ
can-1768	99	7	phase	phase	NOUN
can-1768	99	8	ratio	ratio	NOUN
can-1768	99	9	both	both	PRON
can-1768	99	10	reduce	reduce	VERB
can-1768	99	11	drug	drug	NOUN
can-1768	99	12	loading	loading	NOUN
can-1768	99	13	.	.	PUNCT
can-1768	100	1	the	the	DET
can-1768	100	2	correlation	correlation	NOUN
can-1768	100	3	coefficients	coefficient	NOUN
can-1768	100	4	(	(	PUNCT
can-1768	100	5	r	r	NOUN
can-1768	100	6	)	)	PUNCT
can-1768	100	7	of	of	ADP
can-1768	100	8	the	the	DET
can-1768	100	9	optimized	optimize	VERB
can-1768	100	10	variables	variable	NOUN
can-1768	100	11	were	be	AUX
can-1768	100	12	0.9365	0.9365	NUM
can-1768	100	13	,	,	PUNCT
can-1768	100	14	0.9289	0.9289	NUM
can-1768	100	15	,	,	PUNCT
can-1768	100	16	and	and	CCONJ
can-1768	100	17	0.9698	0.9698	NUM
can-1768	100	18	,	,	PUNCT
can-1768	100	19	respectively	respectively	ADV
can-1768	100	20	,	,	PUNCT
can-1768	100	21	for	for	ADP
can-1768	100	22	the	the	DET
can-1768	100	23	second	second	ADJ
can-1768	100	24	-	-	PUNCT
can-1768	100	25	order	order	NOUN
can-1768	100	26	polynomial	polynomial	ADJ
can-1768	100	27	equation	equation	NOUN
can-1768	100	28	.	.	PUNCT
can-1768	101	1	the	the	DET
can-1768	101	2	r	r	NOUN
can-1768	101	3	value	value	NOUN
can-1768	101	4	reduced	reduce	VERB
can-1768	101	5	significantly	significantly	ADV
can-1768	101	6	to	to	ADP
can-1768	101	7	0.9112	0.9112	NUM
can-1768	101	8	,	,	PUNCT
can-1768	101	9	0.2089	0.2089	NUM
can-1768	101	10	,	,	PUNCT
can-1768	101	11	and	and	CCONJ
can-1768	101	12	0.9312	0.9312	NUM
can-1768	101	13	after	after	ADP
can-1768	101	14	model	model	NOUN
can-1768	101	15	simplification	simplification	NOUN
can-1768	101	16	with	with	ADP
can-1768	101	17	backward	backward	ADJ
can-1768	101	18	stepwise	stepwise	ADJ
can-1768	101	19	solution	solution	NOUN
can-1768	101	20	.	.	PUNCT
can-1768	102	1	at	at	ADP
can-1768	102	2	a	a	DET
can-1768	102	3	95	95	NUM
can-1768	102	4	%	%	NOUN
can-1768	102	5	confidence	confidence	NOUN
can-1768	102	6	level	level	NOUN
can-1768	102	7	,	,	PUNCT
can-1768	102	8	there	there	PRON
can-1768	102	9	was	be	VERB
can-1768	102	10	a	a	DET
can-1768	102	11	substantial	substantial	ADJ
can-1768	102	12	lack	lack	NOUN
can-1768	102	13	of	of	ADP
can-1768	102	14	fit	fit	NOUN
can-1768	102	15	.	.	PUNCT
can-1768	103	1	at	at	ADP
can-1768	103	2	p	p	X
can-1768	103	3	<	<	X
can-1768	103	4	0.05	0.05	NUM
can-1768	103	5	,	,	PUNCT
can-1768	103	6	all	all	PRON
can-1768	103	7	of	of	ADP
can-1768	103	8	the	the	DET
can-1768	103	9	remaining	remain	VERB
can-1768	103	10	variables	variable	NOUN
can-1768	103	11	were	be	AUX
can-1768	103	12	significant	significant	ADJ
can-1768	103	13	.	.	PUNCT
can-1768	104	1	the	the	DET
can-1768	104	2	best	well	ADV
can-1768	104	3	-	-	PUNCT
can-1768	104	4	fitting	fit	VERB
can-1768	104	5	model	model	NOUN
can-1768	104	6	was	be	AUX
can-1768	104	7	the	the	DET
can-1768	104	8	quadratic	quadratic	ADJ
can-1768	104	9	model	model	NOUN
can-1768	104	10	,	,	PUNCT
can-1768	104	11	and	and	CCONJ
can-1768	104	12	the	the	DET
can-1768	104	13	comparative	comparative	ADJ
can-1768	104	14	values	value	NOUN
can-1768	104	15	of	of	ADP
can-1768	104	16	r	r	NOUN
can-1768	104	17	,	,	PUNCT
can-1768	104	18	sd	sd	NOUN
can-1768	104	19	,	,	PUNCT
can-1768	104	20	and	and	CCONJ
can-1768	104	21	percent	percent	NOUN
can-1768	104	22	cv	cv	PROPN
can-1768	104	23	along	along	ADP
can-1768	104	24	with	with	ADP
can-1768	104	25	the	the	DET
can-1768	104	26	regression	regression	NOUN
can-1768	104	27	equation	equation	NOUN
can-1768	104	28	developed	develop	VERB
can-1768	104	29	for	for	ADP
can-1768	104	30	the	the	DET
can-1768	104	31	selected	select	VERB
can-1768	104	32	answers	answer	NOUN
can-1768	104	33	are	be	AUX
can-1768	104	34	shown	show	VERB
can-1768	104	35	in	in	ADP
can-1768	104	36	table	table	NOUN
can-1768	104	37	3	3	NUM
can-1768	104	38	.	.	PUNCT
can-1768	105	1	the	the	DET
can-1768	105	2	following	follow	VERB
can-1768	105	3	polynomial	polynomial	ADJ
can-1768	105	4	equations	equation	NOUN
can-1768	105	5	were	be	AUX
can-1768	105	6	derived	derive	VERB
can-1768	105	7	from	from	ADP
can-1768	105	8	the	the	DET
can-1768	105	9	statistical	statistical	ADJ
can-1768	105	10	analysis	analysis	NOUN
can-1768	105	11	of	of	ADP
can-1768	105	12	the	the	DET
can-1768	105	13	results	result	NOUN
can-1768	105	14	:	:	PUNCT
can-1768	105	15	ps	ps	PROPN
can-1768	105	16	=	=	SYM
can-1768	105	17	+98.57	+98.57	ADJ
can-1768	105	18	–	–	PUNCT
can-1768	105	19	0.1099a	0.1099a	NOUN
can-1768	105	20	–	–	PUNCT
can-1768	105	21	0.5967b	0.5967b	NOUN
can-1768	106	1	+	+	NUM
can-1768	106	2	1.47c	1.47c	NUM
can-1768	106	3	+	+	CCONJ
can-1768	106	4	0.2968ab	0.2968ab	NUM
can-1768	106	5	–	–	PUNCT
can-1768	107	1	0.2167ac	0.2167ac	X
can-1768	108	1	+	+	NUM
can-1768	108	2	2.38bc	2.38bc	NUM
can-1768	108	3	+	+	CCONJ
can-1768	108	4	1.25a2	1.25a2	NUM
can-1768	108	5	–	–	PUNCT
can-1768	108	6	0.3845b2	0.3845b2	NUM
can-1768	109	1	+	+	CCONJ
can-1768	109	2	0.3050c2	0.3050c2	NUM
can-1768	109	3	ee	ee	NOUN
can-1768	109	4	=	=	PUNCT
can-1768	109	5	+91.17	+91.17	PROPN
can-1768	109	6	–	–	PUNCT
can-1768	109	7	2.32a	2.32a	PROPN
can-1768	110	1	+	+	CCONJ
can-1768	111	1	1.16b	1.16b	NUM
can-1768	111	2	+	+	CCONJ
can-1768	111	3	1.32c	1.32c	NUM
can-1768	111	4	+	+	CCONJ
can-1768	111	5	1.98ab	1.98ab	NUM
can-1768	111	6	–	–	PUNCT
can-1768	111	7	0.5109ac	0.5109ac	NUM
can-1768	112	1	+	+	CCONJ
can-1768	112	2	2.45bc	2.45bc	NUM
can-1768	112	3	–	–	PUNCT
can-1768	112	4	2.90a2	2.90a2	NUM
can-1768	112	5	–	–	PUNCT
can-1768	112	6	2,44b2	2,44b2	NUM
can-1768	112	7	–	–	SYM
can-1768	112	8	0.8352c2	0.8352c2	NUM
can-1768	112	9	dl	dl	X
can-1768	112	10	=	=	SYM
can-1768	112	11	+4.04	+4.04	PROPN
can-1768	112	12	+1.09a	+1.09a	NUM
can-1768	112	13	–	–	PUNCT
can-1768	112	14	0.4612b	0.4612b	PUNCT
can-1768	112	15	+	+	CCONJ
can-1768	113	1	0.4446c	0.4446c	ADJ
can-1768	113	2	–	–	PUNCT
can-1768	113	3	0.2717ab	0.2717ab	PROPN
can-1768	114	1	+	+	CCONJ
can-1768	114	2	0.3440ac	0.3440ac	X
can-1768	114	3	–	–	PUNCT
can-1768	114	4	0.6230bc	0.6230bc	NUM
can-1768	115	1	+	+	NUM
can-1768	115	2	1.93a2	1.93a2	NUM
can-1768	115	3	+	+	CCONJ
can-1768	115	4	1.65b2	1.65b2	NUM
can-1768	115	5	+	+	CCONJ
can-1768	115	6	1.50c2	1.50c2	NUM
can-1768	115	7	figure	figure	NOUN
can-1768	115	8	1	1	NUM
can-1768	115	9	.	.	PUNCT
can-1768	115	10	three	three	NUM
can-1768	115	11	-	-	PUNCT
can-1768	115	12	dimensional	dimensional	ADJ
can-1768	115	13	(	(	PUNCT
can-1768	115	14	3d	3d	NUM
can-1768	115	15	)	)	PUNCT
can-1768	115	16	response	response	NOUN
can-1768	115	17	surface	surface	NOUN
can-1768	115	18	plots	plot	NOUN
can-1768	115	19	showing	show	VERB
can-1768	115	20	the	the	DET
can-1768	115	21	effect	effect	NOUN
can-1768	115	22	of	of	ADP
can-1768	115	23	drug	drug	NOUN
can-1768	115	24	/	/	SYM
can-1768	115	25	polymer	polymer	NOUN
can-1768	115	26	ratio	ratio	NOUN
can-1768	115	27	and	and	CCONJ
can-1768	115	28	aqueous	aqueous	ADJ
can-1768	115	29	to	to	ADP
can-1768	115	30	organic	organic	ADJ
can-1768	115	31	phase	phase	NOUN
can-1768	115	32	ratio	ratio	NOUN
can-1768	115	33	on	on	ADP
can-1768	115	34	particle	particle	NOUN
can-1768	115	35	size	size	NOUN
can-1768	115	36	.	.	PUNCT
can-1768	116	1	104	104	NUM
can-1768	116	2	figure	figure	NOUN
can-1768	116	3	2	2	NUM
can-1768	116	4	.	.	PUNCT
can-1768	116	5	three	three	NUM
can-1768	116	6	-	-	PUNCT
can-1768	116	7	dimensional	dimensional	ADJ
can-1768	116	8	(	(	PUNCT
can-1768	116	9	3d	3d	NUM
can-1768	116	10	)	)	PUNCT
can-1768	116	11	response	response	NOUN
can-1768	116	12	surface	surface	NOUN
can-1768	116	13	plots	plot	NOUN
can-1768	116	14	showing	show	VERB
can-1768	116	15	the	the	DET
can-1768	116	16	effect	effect	NOUN
can-1768	116	17	of	of	ADP
can-1768	116	18	drug	drug	NOUN
can-1768	116	19	/	/	SYM
can-1768	116	20	polymer	polymer	NOUN
can-1768	116	21	ratio	ratio	NOUN
can-1768	116	22	and	and	CCONJ
can-1768	116	23	aqueous	aqueous	ADJ
can-1768	116	24	to	to	ADP
can-1768	116	25	organic	organic	ADJ
can-1768	116	26	phase	phase	NOUN
can-1768	116	27	ratio	ratio	NOUN
can-1768	116	28	on	on	ADP
can-1768	116	29	entrapment	entrapment	ADJ
can-1768	116	30	efficiency	efficiency	NOUN
can-1768	116	31	.	.	PUNCT
can-1768	117	1	figure	figure	VERB
can-1768	117	2	3	3	NUM
can-1768	117	3	.	.	PUNCT
can-1768	117	4	three	three	NUM
can-1768	117	5	-	-	PUNCT
can-1768	117	6	dimensional	dimensional	ADJ
can-1768	117	7	(	(	PUNCT
can-1768	117	8	3d	3d	NUM
can-1768	117	9	)	)	PUNCT
can-1768	117	10	response	response	NOUN
can-1768	117	11	surface	surface	NOUN
can-1768	117	12	plots	plot	NOUN
can-1768	117	13	showing	show	VERB
can-1768	117	14	the	the	DET
can-1768	117	15	effect	effect	NOUN
can-1768	117	16	of	of	ADP
can-1768	117	17	drug	drug	NOUN
can-1768	117	18	/	/	SYM
can-1768	117	19	polymer	polymer	NOUN
can-1768	117	20	ratio	ratio	NOUN
can-1768	117	21	and	and	CCONJ
can-1768	117	22	aqueous	aqueous	ADJ
can-1768	117	23	to	to	ADP
can-1768	117	24	organic	organic	ADJ
can-1768	117	25	phase	phase	NOUN
can-1768	117	26	ratio	ratio	NOUN
can-1768	117	27	on	on	ADP
can-1768	117	28	drug	drug	NOUN
can-1768	117	29	loading	loading	NOUN
can-1768	117	30	.	.	PUNCT
can-1768	118	1	105	105	NUM
can-1768	118	2	figure	figure	NOUN
can-1768	118	3	4	4	NUM
can-1768	118	4	.	.	PUNCT
can-1768	118	5	contour	contour	NOUN
can-1768	118	6	plot	plot	NOUN
can-1768	118	7	showing	show	VERB
can-1768	118	8	the	the	DET
can-1768	118	9	desirability	desirability	NOUN
can-1768	118	10	with	with	ADP
can-1768	118	11	a	a	DET
can-1768	118	12	value	value	NOUN
can-1768	118	13	of	of	ADP
can-1768	118	14	0.542	0.542	NUM
can-1768	118	15	.	.	PUNCT
can-1768	119	1	table	table	NOUN
can-1768	119	2	3	3	NUM
can-1768	119	3	.	.	PUNCT
can-1768	119	4	reduced	reduce	VERB
can-1768	119	5	response	response	NOUN
can-1768	119	6	models	model	NOUN
can-1768	119	7	and	and	CCONJ
can-1768	119	8	statistical	statistical	ADJ
can-1768	119	9	parameters	parameter	NOUN
can-1768	119	10	obtained	obtain	VERB
can-1768	119	11	from	from	ADP
can-1768	119	12	anova	anova	PROPN
can-1768	119	13	responses	responses	PROPN
can-1768	119	14	regression	regression	NOUN
can-1768	119	15	model	model	NOUN
can-1768	119	16	adjusted	adjust	VERB
can-1768	119	17	r2	r2	PROPN
can-1768	119	18	model	model	NOUN
can-1768	119	19	p	p	PROPN
can-1768	119	20	value	value	NOUN
can-1768	120	1	%	%	NOUN
can-1768	120	2	cv	cv	PROPN
can-1768	120	3	adequate	adequate	ADJ
can-1768	120	4	precision	precision	NOUN
can-1768	120	5	particle	particle	NOUN
can-1768	120	6	size	size	NOUN
can-1768	120	7	ps	ps	PROPN
can-1768	120	8	=	=	SYM
can-1768	120	9	+98.57	+98.57	ADJ
can-1768	120	10	–	–	PUNCT
can-1768	120	11	0.1099a	0.1099a	NOUN
can-1768	120	12	–	–	PUNCT
can-1768	120	13	0.5967b	0.5967b	NOUN
can-1768	121	1	+	+	NUM
can-1768	121	2	1.47c	1.47c	NUM
can-1768	121	3	+	+	CCONJ
can-1768	121	4	0.2968ab	0.2968ab	NUM
can-1768	121	5	–	–	PUNCT
can-1768	122	1	0.2167ac	0.2167ac	X
can-1768	123	1	+	+	NUM
can-1768	123	2	2.38bc	2.38bc	NUM
can-1768	123	3	+	+	CCONJ
can-1768	123	4	1.25a2	1.25a2	NUM
can-1768	123	5	–	–	PUNCT
can-1768	123	6	0.3845b2	0.3845b2	NUM
can-1768	124	1	+	+	CCONJ
can-1768	124	2	0.3050c2	0.3050c2	NUM
can-1768	124	3	0.9365	0.9365	NUM
can-1768	124	4	0.0001	0.0001	NUM
can-1768	124	5	2.86	2.86	NUM
can-1768	124	6	6.47	6.47	NUM
can-1768	124	7	entrapment	entrapment	ADJ
can-1768	124	8	efficiency	efficiency	NOUN
can-1768	124	9	ee	ee	ADP
can-1768	124	10	=	=	PUNCT
can-1768	124	11	+91.17	+91.17	PROPN
can-1768	124	12	–	–	PUNCT
can-1768	124	13	2.32a	2.32a	PROPN
can-1768	125	1	+	+	CCONJ
can-1768	126	1	1.16b	1.16b	NUM
can-1768	126	2	+	+	CCONJ
can-1768	126	3	1.32c	1.32c	NUM
can-1768	126	4	+	+	CCONJ
can-1768	126	5	1.98ab	1.98ab	NUM
can-1768	126	6	–	–	PUNCT
can-1768	126	7	0.5109ac	0.5109ac	NUM
can-1768	127	1	+	+	CCONJ
can-1768	127	2	2.45bc	2.45bc	NUM
can-1768	127	3	–	–	PUNCT
can-1768	127	4	2.90a2	2.90a2	NUM
can-1768	127	5	–	–	PUNCT
can-1768	127	6	2,44b2	2,44b2	NUM
can-1768	127	7	–	–	SYM
can-1768	127	8	0.8352c2	0.8352c2	NUM
can-1768	127	9	0.9289	0.9289	NUM
can-1768	127	10	0.0001	0.0001	NUM
can-1768	127	11	3.12	3.12	NUM
can-1768	127	12	9.10	9.10	NUM
can-1768	127	13	drug	drug	NOUN
can-1768	127	14	loading	loading	NOUN
can-1768	127	15	dl	dl	PROPN
can-1768	127	16	=	=	NOUN
can-1768	127	17	+4.04	+4.04	PROPN
can-1768	127	18	+1.09a	+1.09a	NUM
can-1768	127	19	–	–	PUNCT
can-1768	127	20	0.4612b	0.4612b	PUNCT
can-1768	127	21	+	+	CCONJ
can-1768	128	1	0.4446c	0.4446c	ADJ
can-1768	128	2	–	–	PUNCT
can-1768	128	3	0.2717	0.2717	NUM
can-1768	128	4	ab	ab	NOUN
can-1768	129	1	+	+	CCONJ
can-1768	129	2	0.3440ac	0.3440ac	NUM
can-1768	129	3	–	–	PUNCT
can-1768	129	4	0.6230bc	0.6230bc	NUM
can-1768	130	1	+	+	NUM
can-1768	130	2	1.93a2	1.93a2	NUM
can-1768	130	3	+	+	SYM
can-1768	130	4	1.65b2	1.65b2	NUM
can-1768	130	5	+	+	CCONJ
can-1768	130	6	1.50c2	1.50c2	NUM
can-1768	130	7	0.9698	0.9698	NUM
can-1768	130	8	0.0001	0.0001	NUM
can-1768	130	9	3.98	3.98	NUM
can-1768	130	10	11.28	11.28	NUM
can-1768	130	11	acceptance	acceptance	NOUN
can-1768	130	12	criteria	criterion	NOUN
can-1768	130	13	1	1	NUM
can-1768	130	14	<	<	X
can-1768	130	15	0.05	0.05	NUM
can-1768	130	16	<	<	X
can-1768	130	17	4	4	NUM
can-1768	130	18	>	>	SYM
can-1768	130	19	4	4	NUM
can-1768	130	20	a	a	DET
can-1768	130	21	drug	drug	NOUN
can-1768	130	22	polymer	polymer	NOUN
can-1768	130	23	to	to	ADP
can-1768	130	24	aqueous	aqueous	ADJ
can-1768	130	25	/	/	SYM
can-1768	130	26	organic	organic	ADJ
can-1768	130	27	phase	phase	NOUN
can-1768	130	28	ratio	ratio	NOUN
can-1768	130	29	of	of	ADP
can-1768	130	30	1:6	1:6	NUM
can-1768	130	31	and	and	CCONJ
can-1768	130	32	a	a	DET
can-1768	130	33	stabilizer	stabilizer	NOUN
can-1768	130	34	concentration	concentration	NOUN
can-1768	130	35	of	of	ADP
can-1768	130	36	0.1	0.1	NUM
can-1768	130	37	%	%	NOUN
can-1768	130	38	produced	produce	VERB
can-1768	130	39	nanoparticles	nanoparticle	NOUN
can-1768	130	40	with	with	ADP
can-1768	130	41	high	high	ADJ
can-1768	130	42	ee	ee	PROPN
can-1768	130	43	,	,	PUNCT
can-1768	130	44	high	high	ADJ
can-1768	130	45	dl	dl	PROPN
can-1768	130	46	,	,	PUNCT
can-1768	130	47	and	and	CCONJ
can-1768	130	48	a	a	DET
can-1768	130	49	small	small	ADJ
can-1768	130	50	mean	mean	ADJ
can-1768	130	51	diameter	diameter	NOUN
can-1768	130	52	,	,	PUNCT
can-1768	130	53	according	accord	VERB
can-1768	130	54	to	to	ADP
can-1768	130	55	the	the	DET
can-1768	130	56	fitting	fitting	ADJ
can-1768	130	57	findings	finding	NOUN
can-1768	130	58	.	.	PUNCT
can-1768	131	1	data	datum	NOUN
can-1768	131	2	from	from	ADP
can-1768	131	3	the	the	DET
can-1768	131	4	two	two	NUM
can-1768	131	5	batches	batch	NOUN
can-1768	131	6	that	that	PRON
can-1768	131	7	were	be	AUX
can-1768	131	8	created	create	VERB
can-1768	131	9	in	in	ADP
can-1768	131	10	optimal	optimal	ADJ
can-1768	131	11	ranges	range	NOUN
can-1768	131	12	were	be	AUX
can-1768	131	13	extremely	extremely	ADV
can-1768	131	14	near	near	ADJ
can-1768	131	15	to	to	ADP
can-1768	131	16	the	the	DET
can-1768	131	17	projected	project	VERB
can-1768	131	18	values	value	NOUN
can-1768	131	19	,	,	PUNCT
can-1768	131	20	with	with	ADP
can-1768	131	21	a	a	DET
can-1768	131	22	minimal	minimal	ADJ
can-1768	131	23	percentage	percentage	NOUN
can-1768	131	24	bias	bias	NOUN
can-1768	131	25	.	.	PUNCT
can-1768	132	1	this	this	PRON
can-1768	132	2	indicates	indicate	VERB
can-1768	132	3	that	that	SCONJ
can-1768	132	4	the	the	DET
can-1768	132	5	optimized	optimize	VERB
can-1768	132	6	formulation	formulation	NOUN
can-1768	132	7	was	be	AUX
can-1768	132	8	trustworthy	trustworthy	ADJ
can-1768	132	9	and	and	CCONJ
can-1768	132	10	reasonable	reasonable	ADJ
can-1768	132	11	.	.	PUNCT
can-1768	133	1	figures	figure	VERB
can-1768	133	2	5–7	5–7	NUM
can-1768	133	3	show	show	VERB
can-1768	133	4	the	the	DET
can-1768	133	5	effect	effect	NOUN
can-1768	133	6	of	of	ADP
can-1768	133	7	an	an	DET
can-1768	133	8	independent	independent	ADJ
can-1768	133	9	factor	factor	NOUN
can-1768	133	10	on	on	ADP
can-1768	133	11	a	a	DET
can-1768	133	12	specific	specific	ADJ
can-1768	133	13	response	response	NOUN
can-1768	133	14	,	,	PUNCT
can-1768	133	15	with	with	SCONJ
can-1768	133	16	all	all	DET
can-1768	133	17	other	other	ADJ
can-1768	133	18	characteristics	characteristic	NOUN
can-1768	133	19	maintained	maintain	VERB
can-1768	133	20	constant	constant	ADJ
can-1768	133	21	at	at	ADP
can-1768	133	22	a	a	DET
can-1768	133	23	reference	reference	NOUN
can-1768	133	24	factor	factor	NOUN
can-1768	133	25	.	.	PUNCT
can-1768	134	1	a	a	DET
can-1768	134	2	high	high	ADJ
can-1768	134	3	inclination	inclination	NOUN
can-1768	134	4	or	or	CCONJ
can-1768	134	5	curve	curve	NOUN
can-1768	134	6	indicates	indicate	VERB
can-1768	134	7	that	that	SCONJ
can-1768	134	8	the	the	DET
can-1768	134	9	reaction	reaction	NOUN
can-1768	134	10	to	to	ADP
can-1768	134	11	a	a	DET
can-1768	134	12	given	give	VERB
can-1768	134	13	element	element	NOUN
can-1768	134	14	is	be	AUX
can-1768	134	15	very	very	ADV
can-1768	134	16	sensitive	sensitive	ADJ
can-1768	134	17	.	.	PUNCT
can-1768	135	1	the	the	DET
can-1768	135	2	aqueous	aqueous	ADJ
can-1768	135	3	-	-	PUNCT
can-1768	135	4	to	to	ADP
can-1768	135	5	-	-	PUNCT
can-1768	135	6	organic	organic	ADJ
can-1768	135	7	phase	phase	NOUN
can-1768	135	8	ratio	ratio	NOUN
can-1768	135	9	,	,	PUNCT
can-1768	135	10	drug	drug	NOUN
can-1768	135	11	polymer	polymer	NOUN
can-1768	135	12	ratio	ratio	NOUN
can-1768	135	13	,	,	PUNCT
can-1768	135	14	and	and	CCONJ
can-1768	135	15	stabilizer	stabilizer	NOUN
can-1768	135	16	concentration	concentration	NOUN
can-1768	135	17	are	be	AUX
can-1768	135	18	all	all	PRON
can-1768	135	19	shown	show	VERB
can-1768	135	20	to	to	PART
can-1768	135	21	have	have	VERB
can-1768	135	22	significant	significant	ADJ
can-1768	135	23	effects	effect	NOUN
can-1768	135	24	on	on	ADP
can-1768	135	25	particle	particle	NOUN
can-1768	135	26	size	size	NOUN
can-1768	135	27	in	in	ADP
can-1768	135	28	figure	figure	NOUN
can-1768	135	29	5	5	NUM
can-1768	135	30	.	.	PUNCT
can-1768	135	31	following	follow	VERB
can-1768	135	32	stabilizer	stabilizer	NOUN
can-1768	135	33	concentration	concentration	NOUN
can-1768	135	34	and	and	CCONJ
can-1768	135	35	drug	drug	NOUN
can-1768	135	36	polymer	polymer	NOUN
can-1768	135	37	ratio	ratio	NOUN
can-1768	135	38	,	,	PUNCT
can-1768	135	39	the	the	DET
can-1768	135	40	aqueous	aqueous	ADJ
can-1768	135	41	to	to	ADP
can-1768	135	42	organic	organic	ADJ
can-1768	135	43	phase	phase	NOUN
can-1768	135	44	ratio	ratio	NOUN
can-1768	135	45	had	have	VERB
can-1768	135	46	the	the	DET
can-1768	135	47	most	most	ADV
can-1768	135	48	significant	significant	ADJ
can-1768	135	49	influence	influence	NOUN
can-1768	135	50	on	on	ADP
can-1768	135	51	entrapment	entrapment	ADJ
can-1768	135	52	efficiency	efficiency	NOUN
can-1768	135	53	,	,	PUNCT
can-1768	135	54	as	as	SCONJ
can-1768	135	55	shown	show	VERB
can-1768	135	56	in	in	ADP
can-1768	135	57	figure	figure	NOUN
can-1768	135	58	6	6	NUM
can-1768	135	59	.	.	PUNCT
can-1768	135	60	drug	drug	NOUN
can-1768	135	61	polymer	polymer	NOUN
can-1768	135	62	ratio	ratio	NOUN
can-1768	135	63	,	,	PUNCT
can-1768	135	64	stabilizer	stabilizer	NOUN
can-1768	135	65	concentration	concentration	NOUN
can-1768	135	66	,	,	PUNCT
can-1768	135	67	and	and	CCONJ
can-1768	135	68	aqueous	aqueous	ADJ
can-1768	135	69	-	-	PUNCT
can-1768	135	70	to	to	ADP
can-1768	135	71	-	-	PUNCT
can-1768	135	72	organic	organic	ADJ
can-1768	135	73	phase	phase	NOUN
can-1768	135	74	ratio	ratio	NOUN
can-1768	135	75	are	be	AUX
can-1768	135	76	shown	show	VERB
can-1768	135	77	in	in	ADP
can-1768	135	78	figure	figure	NOUN
can-1768	135	79	7	7	NUM
can-1768	135	80	to	to	PART
can-1768	135	81	have	have	VERB
can-1768	135	82	the	the	DET
can-1768	135	83	most	most	ADV
can-1768	135	84	significant	significant	ADJ
can-1768	135	85	effect	effect	NOUN
can-1768	135	86	on	on	ADP
can-1768	135	87	drug	drug	NOUN
can-1768	135	88	loading	loading	NOUN
can-1768	135	89	.	.	PUNCT
can-1768	136	1	response	response	NOUN
can-1768	136	2	surface	surface	NOUN
can-1768	136	3	methodology	methodology	NOUN
can-1768	136	4	(	(	PUNCT
can-1768	136	5	rsm	rsm	NOUN
can-1768	136	6	)	)	PUNCT
can-1768	136	7	using	use	VERB
can-1768	136	8	the	the	DET
can-1768	136	9	central	central	ADJ
can-1768	136	10	composite	composite	ADJ
can-1768	136	11	rotatable	rotatable	ADJ
can-1768	136	12	106	106	NUM
can-1768	136	13	design	design	NOUN
can-1768	136	14	model	model	NOUN
can-1768	136	15	was	be	AUX
can-1768	136	16	used	use	VERB
can-1768	136	17	to	to	PART
can-1768	136	18	optimize	optimize	VERB
can-1768	136	19	formulations	formulation	NOUN
can-1768	136	20	of	of	ADP
can-1768	136	21	dihydroartemisinin	dihydroartemisinin	NOUN
can-1768	136	22	nanostructured	nanostructure	VERB
can-1768	136	23	lipid	lipid	NOUN
can-1768	136	24	carrier	carrier	NOUN
can-1768	136	25	.	.	PUNCT
can-1768	137	1	the	the	DET
can-1768	137	2	experimental	experimental	ADJ
can-1768	137	3	values	value	NOUN
can-1768	137	4	of	of	ADP
can-1768	137	5	the	the	DET
can-1768	137	6	nanoparticles	nanoparticle	NOUN
can-1768	137	7	prepared	prepare	VERB
can-1768	137	8	under	under	ADP
can-1768	137	9	the	the	DET
can-1768	137	10	optimum	optimum	ADJ
can-1768	137	11	conditions	condition	NOUN
can-1768	137	12	were	be	AUX
can-1768	137	13	mostly	mostly	ADV
can-1768	137	14	close	close	ADJ
can-1768	137	15	to	to	ADP
can-1768	137	16	the	the	DET
can-1768	137	17	predicted	predict	VERB
can-1768	137	18	values	value	NOUN
can-1768	137	19	(	(	PUNCT
can-1768	137	20	table	table	NOUN
can-1768	137	21	4)[22	4)[22	ADJ
can-1768	137	22	]	]	PUNCT
can-1768	137	23	.	.	PUNCT
can-1768	138	1	the	the	DET
can-1768	138	2	ansamycin	ansamycin	PROPN
can-1768	138	3	-	-	PUNCT
can-1768	138	4	loaded	load	VERB
can-1768	138	5	polymeric	polymeric	ADJ
can-1768	138	6	nanoparticles	nanoparticle	NOUN
can-1768	138	7	were	be	AUX
can-1768	138	8	optimized	optimize	VERB
can-1768	138	9	using	use	VERB
can-1768	138	10	the	the	DET
can-1768	138	11	central	central	ADJ
can-1768	138	12	composite	composite	ADJ
can-1768	138	13	rotatable	rotatable	ADJ
can-1768	138	14	design	design	NOUN
can-1768	138	15	–	–	PUNCT
can-1768	138	16	response	response	NOUN
can-1768	138	17	surface	surface	NOUN
can-1768	138	18	methodology	methodology	NOUN
can-1768	138	19	by	by	ADP
can-1768	138	20	fitting	fit	VERB
can-1768	138	21	a	a	DET
can-1768	138	22	second	second	ADJ
can-1768	138	23	-	-	PUNCT
can-1768	138	24	order	order	NOUN
can-1768	138	25	model	model	NOUN
can-1768	138	26	to	to	ADP
can-1768	138	27	the	the	DET
can-1768	138	28	response	response	NOUN
can-1768	138	29	data	datum	NOUN
can-1768	138	30	and	and	CCONJ
can-1768	138	31	the	the	DET
can-1768	138	32	experimental	experimental	ADJ
can-1768	138	33	values	value	NOUN
can-1768	138	34	of	of	ADP
can-1768	138	35	the	the	DET
can-1768	138	36	nanoparticles	nanoparticle	NOUN
can-1768	138	37	shows	show	VERB
can-1768	138	38	that	that	SCONJ
can-1768	138	39	it	it	PRON
can-1768	138	40	deliver	deliver	VERB
can-1768	138	41	the	the	DET
can-1768	138	42	encapsulated	encapsulate	VERB
can-1768	138	43	drug	drug	NOUN
can-1768	138	44	well	well	NOUN
can-1768	138	45	to	to	ADP
can-1768	138	46	the	the	DET
can-1768	138	47	target	target	NOUN
can-1768	138	48	site[23	site[23	NOUN
can-1768	138	49	]	]	PUNCT
can-1768	138	50	.	.	PUNCT
can-1768	139	1	figure	figure	NOUN
can-1768	139	2	5	5	NUM
can-1768	139	3	.	.	PUNCT
can-1768	139	4	perturbation	perturbation	NOUN
can-1768	139	5	plot	plot	NOUN
can-1768	139	6	showing	show	VERB
can-1768	139	7	the	the	DET
can-1768	139	8	effect	effect	NOUN
can-1768	139	9	of	of	ADP
can-1768	139	10	independent	independent	ADJ
can-1768	139	11	variables	variable	NOUN
can-1768	139	12	on	on	ADP
can-1768	139	13	particle	particle	NOUN
can-1768	139	14	size	size	NOUN
can-1768	139	15	where	where	SCONJ
can-1768	139	16	a	a	DET
can-1768	139	17	,	,	PUNCT
can-1768	139	18	b	b	NOUN
can-1768	139	19	and	and	CCONJ
can-1768	139	20	c	c	PROPN
can-1768	139	21	are	be	AUX
can-1768	139	22	drug	drug	NOUN
can-1768	139	23	/	/	SYM
can-1768	139	24	polymer	polymer	NOUN
can-1768	139	25	ratio	ratio	NOUN
can-1768	139	26	,	,	PUNCT
can-1768	139	27	aqueous	aqueous	ADJ
can-1768	139	28	to	to	ADP
can-1768	139	29	organic	organic	ADJ
can-1768	139	30	phase	phase	NOUN
can-1768	139	31	ratio	ratio	NOUN
can-1768	139	32	and	and	CCONJ
can-1768	139	33	stabilizer	stabilizer	NOUN
can-1768	139	34	concentration	concentration	NOUN
can-1768	139	35	respectively	respectively	ADV
can-1768	139	36	.	.	PUNCT
can-1768	140	1	figure	figure	VERB
can-1768	140	2	6	6	NUM
can-1768	140	3	.	.	PUNCT
can-1768	140	4	perturbation	perturbation	NOUN
can-1768	140	5	plot	plot	NOUN
can-1768	140	6	showing	show	VERB
can-1768	140	7	the	the	DET
can-1768	140	8	effect	effect	NOUN
can-1768	140	9	of	of	ADP
can-1768	140	10	independent	independent	ADJ
can-1768	140	11	variables	variable	NOUN
can-1768	140	12	on	on	ADP
can-1768	140	13	entrapment	entrapment	ADJ
can-1768	140	14	efficiency	efficiency	NOUN
can-1768	140	15	where	where	SCONJ
can-1768	140	16	a	a	DET
can-1768	140	17	,	,	PUNCT
can-1768	140	18	b	b	NOUN
can-1768	140	19	and	and	CCONJ
can-1768	140	20	c	c	PROPN
can-1768	140	21	are	be	AUX
can-1768	140	22	drug	drug	NOUN
can-1768	140	23	/	/	SYM
can-1768	140	24	polymer	polymer	NOUN
can-1768	140	25	ratio	ratio	NOUN
can-1768	140	26	,	,	PUNCT
can-1768	140	27	aqueous	aqueous	ADJ
can-1768	140	28	to	to	ADP
can-1768	140	29	organic	organic	ADJ
can-1768	140	30	phase	phase	NOUN
can-1768	140	31	ratio	ratio	NOUN
can-1768	140	32	and	and	CCONJ
can-1768	140	33	stabilizer	stabilizer	NOUN
can-1768	140	34	concentration	concentration	NOUN
can-1768	140	35	respectively	respectively	ADV
can-1768	140	36	.	.	PUNCT
can-1768	141	1	107	107	NUM
can-1768	141	2	figure	figure	NOUN
can-1768	141	3	7	7	NUM
can-1768	141	4	.	.	PUNCT
can-1768	141	5	perturbation	perturbation	NOUN
can-1768	141	6	plot	plot	NOUN
can-1768	141	7	showing	show	VERB
can-1768	141	8	the	the	DET
can-1768	141	9	effect	effect	NOUN
can-1768	141	10	of	of	ADP
can-1768	141	11	independent	independent	ADJ
can-1768	141	12	variables	variable	NOUN
can-1768	141	13	on	on	ADP
can-1768	141	14	drug	drug	NOUN
can-1768	141	15	loading	loading	NOUN
can-1768	141	16	where	where	SCONJ
can-1768	141	17	a	a	DET
can-1768	141	18	,	,	PUNCT
can-1768	141	19	b	b	NOUN
can-1768	141	20	and	and	CCONJ
can-1768	141	21	c	c	PROPN
can-1768	141	22	are	be	AUX
can-1768	141	23	drug	drug	NOUN
can-1768	141	24	/	/	SYM
can-1768	141	25	polymer	polymer	NOUN
can-1768	141	26	ratio	ratio	NOUN
can-1768	141	27	,	,	PUNCT
can-1768	141	28	aqueous	aqueous	ADJ
can-1768	141	29	to	to	ADP
can-1768	141	30	organic	organic	ADJ
can-1768	141	31	phase	phase	NOUN
can-1768	141	32	ratio	ratio	NOUN
can-1768	141	33	and	and	CCONJ
can-1768	141	34	stabilizer	stabilizer	NOUN
can-1768	141	35	concentration	concentration	NOUN
can-1768	141	36	respectively	respectively	ADV
can-1768	141	37	.	.	PUNCT
can-1768	141	38	table	table	NOUN
can-1768	141	39	4	4	NUM
can-1768	141	40	.	.	NUM
can-1768	141	41	predicted	predict	VERB
can-1768	141	42	and	and	CCONJ
can-1768	141	43	experimental	experimental	ADJ
can-1768	141	44	values	value	NOUN
can-1768	141	45	under	under	ADP
can-1768	141	46	predicted	predict	VERB
can-1768	141	47	optimal	optimal	ADJ
can-1768	141	48	conditions	condition	NOUN
can-1768	141	49	drug	drug	NOUN
can-1768	141	50	/	/	SYM
can-1768	141	51	polymer	polymer	NOUN
can-1768	141	52	ratio	ratio	NOUN
can-1768	141	53	aqueous	aqueous	ADJ
can-1768	141	54	to	to	ADP
can-1768	141	55	organic	organic	ADJ
can-1768	141	56	phase	phase	NOUN
can-1768	141	57	ratio	ratio	NOUN
can-1768	141	58	stabilizer	stabilizer	NOUN
can-1768	141	59	concentration	concentration	NOUN
can-1768	141	60	(	(	PUNCT
can-1768	141	61	%	%	INTJ
can-1768	141	62	)	)	PUNCT
can-1768	141	63	particle	particle	NOUN
can-1768	141	64	size	size	NOUN
can-1768	141	65	(	(	PUNCT
can-1768	141	66	nm	nm	NOUN
can-1768	141	67	)	)	PUNCT
can-1768	141	68	entrapment	entrapment	ADJ
can-1768	141	69	efficiency	efficiency	NOUN
can-1768	141	70	(	(	PUNCT
can-1768	141	71	%	%	INTJ
can-1768	141	72	)	)	PUNCT
can-1768	141	73	drug	drug	NOUN
can-1768	141	74	loading	loading	NOUN
can-1768	141	75	(	(	PUNCT
can-1768	141	76	%	%	NOUN
can-1768	141	77	)	)	PUNCT
can-1768	141	78	1:8.27	1:8.27	NUM
can-1768	141	79	1:6	1:6	NUM
can-1768	141	80	0.1	0.1	NUM
can-1768	141	81	predicted	predict	VERB
can-1768	141	82	114	114	NUM
can-1768	141	83	83.5	83.5	NUM
can-1768	141	84	8.6	8.6	NUM
can-1768	141	85	experimental	experimental	ADJ
can-1768	141	86	112	112	NUM
can-1768	141	87	85.4	85.4	NUM
can-1768	141	88	9.0	9.0	NUM
can-1768	141	89	bias	bias	NOUN
can-1768	141	90	%	%	NOUN
can-1768	141	91	1.75	1.75	NUM
can-1768	141	92	%	%	NOUN
can-1768	141	93	2.27	2.27	NUM
can-1768	141	94	%	%	NOUN
can-1768	141	95	4.6	4.6	NUM
can-1768	141	96	%	%	NOUN
can-1768	141	97	acceptance	acceptance	NOUN
can-1768	141	98	criteria	criterion	NOUN
can-1768	141	99	6	6	NUM
can-1768	141	100	%	%	NOUN
can-1768	141	101	bias	bias	NOUN
can-1768	141	102	was	be	AUX
can-1768	141	103	calculated	calculate	VERB
can-1768	141	104	as	as	SCONJ
can-1768	141	105	(	(	PUNCT
can-1768	141	106	predicted	predict	VERB
can-1768	141	107	value	value	NOUN
can-1768	141	108	experimental	experimental	ADJ
can-1768	141	109	value)/predicted	value)/predicte	VERB
can-1768	141	110	value	value	NOUN
can-1768	141	111	×	×	NOUN
can-1768	141	112	100	100	NUM
can-1768	141	113	3.2	3.2	NUM
can-1768	141	114	particle	particle	NOUN
can-1768	141	115	size	size	NOUN
can-1768	141	116	,	,	PUNCT
can-1768	141	117	zeta	zeta	NOUN
can-1768	141	118	potential	potential	NOUN
can-1768	141	119	and	and	CCONJ
can-1768	141	120	sem	sem	NOUN
can-1768	141	121	measurement	measurement	NOUN
can-1768	141	122	it	it	PRON
can-1768	141	123	was	be	AUX
can-1768	141	124	discovered	discover	VERB
can-1768	141	125	that	that	SCONJ
can-1768	141	126	the	the	DET
can-1768	141	127	average	average	ADJ
can-1768	141	128	cisplatin	cisplatin	NOUN
can-1768	141	129	nanoparticle	nanoparticle	NOUN
can-1768	141	130	particle	particle	NOUN
can-1768	141	131	size	size	NOUN
can-1768	141	132	was	be	AUX
can-1768	141	133	112	112	NUM
can-1768	141	134	nm	nm	NOUN
can-1768	141	135	(	(	PUNCT
can-1768	141	136	figure	figure	NOUN
can-1768	141	137	8)	8)	NUM
can-1768	141	138	.	.	PUNCT
can-1768	142	1	as	as	SCONJ
can-1768	142	2	shown	show	VERB
can-1768	142	3	in	in	ADP
can-1768	142	4	figure	figure	NOUN
can-1768	142	5	9	9	NUM
can-1768	142	6	,	,	PUNCT
can-1768	142	7	the	the	DET
can-1768	142	8	zeta	zeta	NOUN
can-1768	142	9	potential	potential	NOUN
can-1768	142	10	of	of	ADP
can-1768	142	11	this	this	DET
can-1768	142	12	compound	compound	NOUN
can-1768	142	13	is	be	AUX
can-1768	142	14	high	high	ADJ
can-1768	142	15	enough	enough	ADV
can-1768	142	16	to	to	PART
can-1768	142	17	allow	allow	VERB
can-1768	142	18	for	for	ADP
can-1768	142	19	the	the	DET
can-1768	142	20	creation	creation	NOUN
can-1768	142	21	of	of	ADP
can-1768	142	22	a	a	DET
can-1768	142	23	stable	stable	ADJ
can-1768	142	24	pharmaceutical	pharmaceutical	NOUN
can-1768	142	25	formulation	formulation	NOUN
can-1768	142	26	.	.	PUNCT
can-1768	143	1	figure	figure	NOUN
can-1768	143	2	10	10	NUM
can-1768	143	3	shows	show	VERB
can-1768	143	4	the	the	DET
can-1768	143	5	sem	sem	NOUN
can-1768	143	6	images	image	NOUN
can-1768	143	7	taken	take	VERB
can-1768	143	8	of	of	ADP
can-1768	143	9	the	the	DET
can-1768	143	10	improved	improved	ADJ
can-1768	143	11	cisplatin	cisplatin	NOUN
can-1768	143	12	nanoparticles	nanoparticle	NOUN
can-1768	143	13	to	to	PART
can-1768	143	14	offer	offer	VERB
can-1768	143	15	information	information	NOUN
can-1768	143	16	on	on	ADP
can-1768	143	17	their	their	PRON
can-1768	143	18	shape	shape	NOUN
can-1768	143	19	.	.	PUNCT
can-1768	144	1	these	these	DET
can-1768	144	2	nanoparticles	nanoparticle	NOUN
can-1768	144	3	have	have	AUX
can-1768	144	4	been	be	AUX
can-1768	144	5	fine	fine	ADV
can-1768	144	6	-	-	PUNCT
can-1768	144	7	tuned	tune	VERB
can-1768	144	8	to	to	PART
can-1768	144	9	be	be	AUX
can-1768	144	10	spherical	spherical	ADJ
can-1768	144	11	.	.	PUNCT
can-1768	145	1	the	the	DET
can-1768	145	2	nanoparticles	nanoparticle	NOUN
can-1768	145	3	had	have	VERB
can-1768	145	4	the	the	DET
can-1768	145	5	higher	high	ADJ
can-1768	145	6	absolute	absolute	ADJ
can-1768	145	7	values	value	NOUN
can-1768	145	8	of	of	ADP
can-1768	145	9	zeta	zeta	PROPN
can-1768	145	10	potential	potential	NOUN
can-1768	145	11	,	,	PUNCT
can-1768	145	12	indicating	indicate	VERB
can-1768	145	13	a	a	DET
can-1768	145	14	better	well	ADJ
can-1768	145	15	stability	stability	NOUN
can-1768	145	16	of	of	ADP
can-1768	145	17	this	this	DET
can-1768	145	18	colloid	colloid	NOUN
can-1768	145	19	system[24	system[24	NOUN
can-1768	145	20	]	]	PUNCT
can-1768	145	21	.	.	PUNCT
can-1768	146	1	zeta	zeta	PROPN
can-1768	146	2	potential	potential	NOUN
can-1768	146	3	under	under	ADP
can-1768	146	4	−30	−30	NOUN
can-1768	146	5	mv	mv	PROPN
can-1768	146	6	showed	show	VERB
can-1768	146	7	good	good	ADJ
can-1768	146	8	physical	physical	ADJ
can-1768	146	9	stability[25	stability[25	PROPN
can-1768	146	10	]	]	PUNCT
can-1768	146	11	.	.	PUNCT
can-1768	147	1	figure	figure	NOUN
can-1768	147	2	8	8	NUM
can-1768	147	3	.	.	NOUN
can-1768	147	4	size	size	NOUN
can-1768	147	5	distribution	distribution	NOUN
can-1768	147	6	of	of	ADP
can-1768	147	7	cisplatin	cisplatin	NOUN
can-1768	147	8	plga	plga	NOUN
can-1768	147	9	np	np	INTJ
can-1768	147	10	.	.	PROPN
can-1768	147	11	108	108	NUM
can-1768	147	12	figure	figure	NOUN
can-1768	147	13	9	9	NUM
can-1768	147	14	.	.	PUNCT
can-1768	147	15	zeta	zeta	PROPN
can-1768	147	16	potential	potential	NOUN
can-1768	147	17	of	of	ADP
can-1768	147	18	cisplatin	cisplatin	NOUN
can-1768	147	19	plga	plga	NOUN
can-1768	147	20	np	np	INTJ
can-1768	147	21	.	.	PROPN
can-1768	147	22	figure	figure	NOUN
can-1768	147	23	10	10	NUM
can-1768	147	24	.	.	PUNCT
can-1768	148	1	scanning	scan	VERB
can-1768	148	2	electron	electron	NOUN
can-1768	148	3	microscopy	microscopy	NOUN
can-1768	148	4	of	of	ADP
can-1768	148	5	cisplatin	cisplatin	NOUN
can-1768	148	6	plga	plga	NOUN
can-1768	148	7	np	np	INTJ
can-1768	148	8	.	.	PROPN
can-1768	148	9	3.3	3.3	NUM
can-1768	148	10	differential	differential	NOUN
can-1768	148	11	scanning	scan	VERB
can-1768	148	12	calorimetry	calorimetry	NOUN
can-1768	148	13	(	(	PUNCT
can-1768	148	14	dsc	dsc	NOUN
can-1768	148	15	)	)	PUNCT
can-1768	148	16	analysis	analysis	NOUN
can-1768	148	17	after	after	ADP
can-1768	148	18	the	the	DET
can-1768	148	19	preparation	preparation	NOUN
can-1768	148	20	,	,	PUNCT
can-1768	148	21	dsc	dsc	PROPN
can-1768	148	22	was	be	AUX
can-1768	148	23	used	use	VERB
can-1768	148	24	to	to	PART
can-1768	148	25	examine	examine	VERB
can-1768	148	26	the	the	DET
can-1768	148	27	cisplatin	cisplatin	NOUN
can-1768	148	28	’s	’s	PART
can-1768	148	29	physical	physical	ADJ
can-1768	148	30	condition	condition	NOUN
can-1768	148	31	within	within	ADP
can-1768	148	32	the	the	DET
can-1768	148	33	plga	plga	NOUN
can-1768	148	34	particles	particle	NOUN
can-1768	148	35	.	.	PUNCT
can-1768	149	1	drug	drug	NOUN
can-1768	149	2	-	-	PUNCT
can-1768	149	3	loaded	load	VERB
can-1768	149	4	nanoparticles	nanoparticle	NOUN
can-1768	149	5	did	do	AUX
can-1768	149	6	not	not	PART
can-1768	149	7	exhibit	exhibit	VERB
can-1768	149	8	the	the	DET
can-1768	149	9	glass	glass	NOUN
can-1768	149	10	transition	transition	NOUN
can-1768	149	11	peak	peak	NOUN
can-1768	149	12	seen	see	VERB
can-1768	149	13	in	in	ADP
can-1768	149	14	the	the	DET
can-1768	149	15	dsc	dsc	NOUN
can-1768	149	16	thermogram	thermogram	NOUN
can-1768	149	17	of	of	ADP
can-1768	149	18	plga	plga	NOUN
can-1768	149	19	(	(	PUNCT
can-1768	149	20	figure	figure	NOUN
can-1768	149	21	11	11	NUM
can-1768	149	22	)	)	PUNCT
can-1768	149	23	.	.	PUNCT
can-1768	150	1	the	the	DET
can-1768	150	2	cisplatin	cisplatin	PROPN
can-1768	150	3	thermogram	thermogram	PROPN
can-1768	150	4	revealed	reveal	VERB
can-1768	150	5	an	an	DET
can-1768	150	6	exothermic	exothermic	ADJ
can-1768	150	7	peak	peak	NOUN
can-1768	150	8	at	at	ADP
can-1768	150	9	280–285	280–285	NUM
can-1768	150	10	°	°	ADP
can-1768	150	11	c	c	NOUN
can-1768	150	12	.	.	PUNCT
can-1768	151	1	it	it	PRON
can-1768	151	2	is	be	AUX
can-1768	151	3	possible	possible	ADJ
can-1768	151	4	that	that	SCONJ
can-1768	151	5	the	the	DET
can-1768	151	6	drug	drug	NOUN
can-1768	151	7	is	be	AUX
can-1768	151	8	scattered	scatter	VERB
can-1768	151	9	in	in	ADP
can-1768	151	10	an	an	DET
can-1768	151	11	amorphous	amorphous	ADJ
can-1768	151	12	form	form	NOUN
can-1768	151	13	due	due	ADP
can-1768	151	14	to	to	ADP
can-1768	151	15	its	its	PRON
can-1768	151	16	lack	lack	NOUN
can-1768	151	17	of	of	ADP
can-1768	151	18	this	this	DET
can-1768	151	19	characteristic	characteristic	ADJ
can-1768	151	20	peak	peak	NOUN
can-1768	151	21	.	.	PUNCT
can-1768	152	1	3.4	3.4	NUM
can-1768	152	2	fourier	fourier	NOUN
can-1768	152	3	transform	transform	VERB
can-1768	152	4	infrared	infrared	ADJ
can-1768	152	5	spectroscopy	spectroscopy	NOUN
can-1768	152	6	(	(	PUNCT
can-1768	152	7	ftir	ftir	PROPN
can-1768	152	8	)	)	PUNCT
can-1768	152	9	analysis	analysis	NOUN
can-1768	152	10	ftir	ftir	NOUN
can-1768	152	11	analysis	analysis	NOUN
can-1768	152	12	is	be	AUX
can-1768	152	13	used	use	VERB
can-1768	152	14	to	to	PART
can-1768	152	15	study	study	VERB
can-1768	152	16	the	the	DET
can-1768	152	17	interactions	interaction	NOUN
can-1768	152	18	between	between	ADP
can-1768	152	19	cisplatin	cisplatin	NOUN
can-1768	152	20	and	and	CCONJ
can-1768	152	21	plga	plga	NOUN
can-1768	152	22	during	during	ADP
can-1768	152	23	the	the	DET
can-1768	152	24	entrapment	entrapment	ADJ
can-1768	152	25	procedure	procedure	NOUN
can-1768	152	26	and	and	CCONJ
can-1768	152	27	the	the	DET
can-1768	152	28	ftir	ftir	PROPN
can-1768	152	29	spectrum	spectrum	PROPN
can-1768	152	30	obtained	obtain	VERB
can-1768	152	31	for	for	ADP
can-1768	152	32	cisplatin	cisplatin	NOUN
can-1768	152	33	,	,	PUNCT
can-1768	152	34	plga	plga	NOUN
can-1768	152	35	,	,	PUNCT
can-1768	152	36	physical	physical	ADJ
can-1768	152	37	mixture	mixture	NOUN
can-1768	152	38	and	and	CCONJ
can-1768	152	39	the	the	DET
can-1768	152	40	drug	drug	NOUN
can-1768	152	41	loaded	load	VERB
can-1768	152	42	nanoparticle	nanoparticle	NOUN
can-1768	152	43	is	be	AUX
can-1768	152	44	presented	present	VERB
can-1768	152	45	in	in	ADP
can-1768	152	46	figure	figure	NOUN
can-1768	152	47	12	12	NUM
can-1768	152	48	.	.	PUNCT
can-1768	153	1	figure	figure	NOUN
can-1768	153	2	11	11	NUM
can-1768	153	3	.	.	PUNCT
can-1768	154	1	dsc	dsc	NOUN
can-1768	154	2	thermogram	thermogram	NOUN
can-1768	154	3	of	of	ADP
can-1768	154	4	plga	plga	NOUN
can-1768	154	5	(	(	PUNCT
can-1768	154	6	polymer	polymer	NOUN
can-1768	154	7	)	)	PUNCT
can-1768	154	8	,	,	PUNCT
can-1768	154	9	cisplatin	cisplatin	NOUN
can-1768	154	10	(	(	PUNCT
can-1768	154	11	drug	drug	NOUN
can-1768	154	12	)	)	PUNCT
can-1768	154	13	,	,	PUNCT
can-1768	154	14	plga	plga	VERB
can-1768	154	15	cisplatin	cisplatin	NOUN
can-1768	154	16	mixture	mixture	NOUN
can-1768	154	17	,	,	PUNCT
can-1768	154	18	cisplatin	cisplatin	NOUN
can-1768	154	19	plga	plga	NOUN
can-1768	154	20	np	np	INTJ
can-1768	154	21	.	.	PROPN
can-1768	154	22	figure	figure	NOUN
can-1768	154	23	12	12	NUM
can-1768	154	24	.	.	PUNCT
can-1768	155	1	ftir	ftir	PROPN
can-1768	155	2	spectra	spectra	PROPN
can-1768	155	3	of	of	ADP
can-1768	155	4	plga	plga	NOUN
can-1768	155	5	(	(	PUNCT
can-1768	155	6	polymer	polymer	NOUN
can-1768	155	7	)	)	PUNCT
can-1768	155	8	,	,	PUNCT
can-1768	155	9	cisplatin	cisplatin	NOUN
can-1768	155	10	(	(	PUNCT
can-1768	155	11	drug	drug	NOUN
can-1768	155	12	)	)	PUNCT
can-1768	155	13	,	,	PUNCT
can-1768	155	14	plga	plga	VERB
can-1768	155	15	cisplatin	cisplatin	NOUN
can-1768	155	16	mixture	mixture	NOUN
can-1768	155	17	,	,	PUNCT
can-1768	155	18	cisplatin	cisplatin	NOUN
can-1768	155	19	plga	plga	NOUN
can-1768	155	20	np	np	INTJ
can-1768	155	21	.	.	PUNCT
can-1768	156	1	the	the	DET
can-1768	156	2	pure	pure	ADJ
can-1768	156	3	cisplatin	cisplatin	NOUN
can-1768	156	4	obtained	obtain	VERB
can-1768	156	5	the	the	DET
can-1768	156	6	characteristic	characteristic	ADJ
can-1768	156	7	peaks	peak	NOUN
can-1768	156	8	that	that	PRON
can-1768	156	9	includes	include	VERB
can-1768	156	10	amine	amine	ADJ
can-1768	156	11	stretching	stretching	NOUN
can-1768	156	12	(	(	PUNCT
can-1768	156	13	3,208	3,208	NUM
can-1768	156	14	cm−1	cm−1	NOUN
can-1768	156	15	)	)	PUNCT
can-1768	156	16	,	,	PUNCT
can-1768	156	17	symmetric	symmetric	ADJ
can-1768	156	18	amine	amine	ADJ
can-1768	156	19	bending	bending	NOUN
can-1768	156	20	(	(	PUNCT
can-1768	156	21	1,302	1,302	NUM
can-1768	156	22	cm−1	cm−1	NOUN
can-1768	156	23	)	)	PUNCT
can-1768	156	24	and	and	CCONJ
can-1768	156	25	chloride	chloride	NOUN
can-1768	156	26	stretching	stretching	NOUN
can-1768	156	27	(	(	PUNCT
can-1768	156	28	766	766	NUM
can-1768	156	29	cm−1	cm−1	NOUN
can-1768	156	30	)	)	PUNCT
can-1768	156	31	.	.	PUNCT
can-1768	157	1	plga	plga	NOUN
can-1768	157	2	nanoparticles	nanoparticle	NOUN
can-1768	157	3	obtained	obtain	VERB
can-1768	157	4	its	its	PRON
can-1768	157	5	characteristic	characteristic	ADJ
can-1768	157	6	peaks	peak	NOUN
can-1768	157	7	that	that	PRON
can-1768	157	8	include	include	VERB
can-1768	157	9	c	c	NOUN
can-1768	157	10	=	=	SYM
can-1768	157	11	o	o	NOUN
can-1768	157	12	stretching	stretching	NOUN
can-1768	157	13	(	(	PUNCT
can-1768	157	14	1,728	1,728	NUM
can-1768	157	15	cm−1	cm−1	NOUN
can-1768	157	16	)	)	PUNCT
can-1768	157	17	and	and	CCONJ
can-1768	157	18	c	c	X
can-1768	157	19	-	-	PUNCT
can-1768	157	20	o	o	NOUN
can-1768	157	21	stretching	stretching	NOUN
can-1768	157	22	(	(	PUNCT
can-1768	157	23	1,020–1,280	1,020–1,280	NUM
can-1768	157	24	cm−1	cm−1	NOUN
can-1768	157	25	)	)	PUNCT
can-1768	157	26	.	.	PUNCT
can-1768	158	1	the	the	DET
can-1768	158	2	ftir	ftir	PROPN
can-1768	158	3	spectra	spectra	PROPN
can-1768	158	4	of	of	ADP
can-1768	158	5	the	the	DET
can-1768	158	6	cisplatin	cisplatin	NOUN
can-1768	158	7	loaded	load	VERB
can-1768	158	8	nanoparticles	nanoparticle	NOUN
can-1768	158	9	obtained	obtain	VERB
can-1768	158	10	a	a	DET
can-1768	158	11	peak	peak	NOUN
can-1768	158	12	for	for	ADP
can-1768	158	13	amine	amine	ADJ
can-1768	158	14	stretching	stretching	NOUN
can-1768	158	15	(	(	PUNCT
can-1768	158	16	3,279	3,279	NUM
can-1768	158	17	cm−1	cm−1	NOUN
can-1768	158	18	)	)	PUNCT
can-1768	158	19	,	,	PUNCT
can-1768	158	20	indicating	indicate	VERB
can-1768	158	21	the	the	DET
can-1768	158	22	presence	presence	NOUN
can-1768	158	23	of	of	ADP
can-1768	158	24	cisplatin	cisplatin	NOUN
can-1768	158	25	in	in	ADP
can-1768	158	26	the	the	DET
can-1768	158	27	formulation	formulation	NOUN
can-1768	158	28	.	.	PUNCT
can-1768	159	1	the	the	DET
can-1768	159	2	ftir	ftir	PROPN
can-1768	159	3	data	data	PROPN
can-1768	159	4	obtained	obtain	VERB
can-1768	159	5	indicates	indicate	VERB
can-1768	159	6	that	that	SCONJ
can-1768	159	7	there	there	PRON
can-1768	159	8	were	be	VERB
can-1768	159	9	no	no	DET
can-1768	159	10	chemical	chemical	ADJ
can-1768	159	11	interactions	interaction	NOUN
can-1768	159	12	between	between	ADP
can-1768	159	13	plga	plga	NOUN
can-1768	159	14	and	and	CCONJ
can-1768	159	15	the	the	DET
can-1768	159	16	study	study	NOUN
can-1768	159	17	drug	drug	NOUN
can-1768	159	18	cisplatin	cisplatin	NOUN
can-1768	159	19	.	.	PUNCT
can-1768	160	1	3.5	3.5	NUM
can-1768	160	2	in	in	ADP
can-1768	160	3	vitro	vitro	X
can-1768	160	4	drug	drug	NOUN
can-1768	160	5	release	release	NOUN
can-1768	160	6	study	study	NOUN
can-1768	160	7	in	in	ADP
can-1768	160	8	vitro	vitro	X
can-1768	160	9	cisplatin	cisplatin	NOUN
can-1768	160	10	release	release	NOUN
can-1768	160	11	from	from	ADP
can-1768	160	12	plga	plga	NOUN
can-1768	160	13	nanoparticles	nanoparticle	NOUN
can-1768	160	14	is	be	AUX
can-1768	160	15	presented	present	VERB
can-1768	160	16	in	in	ADP
can-1768	160	17	figure	figure	NOUN
can-1768	160	18	13	13	NUM
can-1768	160	19	.	.	PUNCT
can-1768	161	1	biphasic	biphasic	ADJ
can-1768	161	2	109	109	NUM
can-1768	161	3	release	release	NOUN
can-1768	161	4	pattern	pattern	NOUN
can-1768	161	5	with	with	ADP
can-1768	161	6	an	an	DET
can-1768	161	7	initial	initial	ADJ
can-1768	161	8	fast	fast	ADJ
can-1768	161	9	release	release	NOUN
can-1768	161	10	for	for	ADP
can-1768	161	11	the	the	DET
can-1768	161	12	first	first	ADJ
can-1768	161	13	48	48	NUM
can-1768	161	14	hrs	hrs	NOUN
can-1768	161	15	,	,	PUNCT
can-1768	161	16	followed	follow	VERB
can-1768	161	17	by	by	ADP
can-1768	161	18	a	a	DET
can-1768	161	19	steady	steady	ADJ
can-1768	161	20	release	release	NOUN
can-1768	161	21	for	for	ADP
can-1768	161	22	six	six	NUM
can-1768	161	23	days	day	NOUN
can-1768	161	24	is	be	AUX
can-1768	161	25	observed	observe	VERB
can-1768	161	26	.	.	PUNCT
can-1768	162	1	the	the	DET
can-1768	162	2	drug	drug	NOUN
can-1768	162	3	may	may	AUX
can-1768	162	4	have	have	AUX
can-1768	162	5	accumulated	accumulate	VERB
can-1768	162	6	on	on	ADP
can-1768	162	7	the	the	DET
can-1768	162	8	nanoparticle	nanoparticle	NOUN
can-1768	162	9	surface	surface	NOUN
can-1768	162	10	during	during	ADP
can-1768	162	11	manufacturing	manufacturing	NOUN
can-1768	162	12	,	,	PUNCT
can-1768	162	13	resulting	result	VERB
can-1768	162	14	in	in	ADP
can-1768	162	15	a	a	DET
can-1768	162	16	fast	fast	ADJ
can-1768	162	17	release	release	NOUN
can-1768	162	18	.	.	PUNCT
can-1768	163	1	comparison	comparison	NOUN
can-1768	163	2	of	of	ADP
can-1768	163	3	cisplatin	cisplatin	NOUN
can-1768	163	4	release	release	NOUN
can-1768	163	5	profiles	profile	NOUN
can-1768	163	6	with	with	ADP
can-1768	163	7	those	those	PRON
can-1768	163	8	of	of	ADP
can-1768	163	9	cisplatin	cisplatin	NOUN
can-1768	163	10	solution	solution	NOUN
can-1768	163	11	demonstrates	demonstrate	VERB
can-1768	163	12	that	that	SCONJ
can-1768	163	13	nanoparticle	nanoparticle	NOUN
can-1768	163	14	entrapment	entrapment	NOUN
can-1768	163	15	greatly	greatly	ADV
can-1768	163	16	slowed	slow	VERB
can-1768	163	17	cisplatin	cisplatin	NOUN
can-1768	163	18	’s	’s	PART
can-1768	163	19	release	release	NOUN
can-1768	163	20	from	from	ADP
can-1768	163	21	the	the	DET
can-1768	163	22	solution	solution	NOUN
can-1768	163	23	.	.	PUNCT
can-1768	164	1	according	accord	VERB
can-1768	164	2	to	to	ADP
can-1768	164	3	the	the	DET
can-1768	164	4	data	datum	NOUN
can-1768	164	5	(	(	PUNCT
can-1768	164	6	figure	figure	NOUN
can-1768	164	7	13	13	NUM
can-1768	164	8	)	)	PUNCT
can-1768	164	9	,	,	PUNCT
can-1768	164	10	roughly	roughly	ADV
can-1768	164	11	90	90	NUM
can-1768	164	12	%	%	NOUN
can-1768	164	13	of	of	ADP
can-1768	164	14	cisplatin	cisplatin	NOUN
can-1768	164	15	in	in	ADP
can-1768	164	16	phosphate	phosphate	ADJ
can-1768	164	17	buffer	buffer	NOUN
can-1768	164	18	solution	solution	NOUN
can-1768	164	19	was	be	AUX
can-1768	164	20	released	release	VERB
can-1768	164	21	in	in	ADP
can-1768	164	22	24	24	NUM
can-1768	164	23	hours	hour	NOUN
can-1768	164	24	.	.	PUNCT
can-1768	165	1	for	for	ADP
can-1768	165	2	the	the	DET
can-1768	165	3	next	next	ADJ
can-1768	165	4	six	six	NUM
can-1768	165	5	days	day	NOUN
can-1768	165	6	,	,	PUNCT
can-1768	165	7	the	the	DET
can-1768	165	8	cisplatin	cisplatin	NOUN
can-1768	165	9	nanoparticles	nanoparticle	NOUN
can-1768	165	10	released	release	VERB
can-1768	165	11	at	at	ADP
can-1768	165	12	a	a	DET
can-1768	165	13	consistent	consistent	ADJ
can-1768	165	14	and	and	CCONJ
can-1768	165	15	modest	modest	ADJ
can-1768	165	16	rate	rate	NOUN
can-1768	165	17	.	.	PUNCT
can-1768	166	1	in	in	ADP
can-1768	166	2	vitro	vitro	X
can-1768	166	3	,	,	PUNCT
can-1768	166	4	the	the	DET
can-1768	166	5	cisplatin	cisplatin	NOUN
can-1768	166	6	nanoparticles	nanoparticle	NOUN
can-1768	166	7	showed	show	VERB
can-1768	166	8	a	a	DET
can-1768	166	9	clear	clear	ADJ
can-1768	166	10	sustained	sustain	VERB
can-1768	166	11	-	-	PUNCT
can-1768	166	12	release	release	NOUN
can-1768	166	13	impact	impact	NOUN
can-1768	166	14	as	as	SCONJ
can-1768	166	15	compared	compare	VERB
can-1768	166	16	to	to	ADP
can-1768	166	17	cisplatin	cisplatin	NOUN
can-1768	166	18	.	.	PUNCT
can-1768	167	1	the	the	DET
can-1768	167	2	decreased	decrease	VERB
can-1768	167	3	percentage	percentage	NOUN
can-1768	167	4	of	of	ADP
can-1768	167	5	cumulative	cumulative	ADJ
can-1768	167	6	drug	drug	NOUN
can-1768	167	7	release	release	NOUN
can-1768	167	8	may	may	AUX
can-1768	167	9	be	be	AUX
can-1768	167	10	due	due	ADJ
can-1768	167	11	to	to	ADP
can-1768	167	12	the	the	DET
can-1768	167	13	enhanced	enhance	VERB
can-1768	167	14	particle	particle	NOUN
can-1768	167	15	size	size	NOUN
can-1768	167	16	and	and	CCONJ
can-1768	167	17	also	also	ADV
can-1768	167	18	hence	hence	ADV
can-1768	167	19	smaller	small	ADJ
can-1768	167	20	sized	sized	ADJ
can-1768	167	21	surface	surface	NOUN
can-1768	167	22	area	area	NOUN
can-1768	167	23	at	at	ADP
can-1768	167	24	greater	great	ADJ
can-1768	167	25	polymer	polymer	NOUN
can-1768	167	26	concentration	concentration	NOUN
can-1768	167	27	.	.	PUNCT
can-1768	168	1	an	an	DET
can-1768	168	2	additional	additional	ADJ
can-1768	168	3	description	description	NOUN
can-1768	168	4	for	for	ADP
can-1768	168	5	reduced	reduce	VERB
can-1768	168	6	cumulative	cumulative	ADJ
can-1768	168	7	drug	drug	NOUN
can-1768	168	8	release	release	NOUN
can-1768	168	9	at	at	ADP
can-1768	168	10	greater	great	ADJ
can-1768	168	11	polymer	polymer	NOUN
can-1768	168	12	concentration	concentration	NOUN
can-1768	168	13	might	might	AUX
can-1768	168	14	be	be	AUX
can-1768	168	15	the	the	DET
can-1768	168	16	enhanced	enhanced	ADJ
can-1768	168	17	concentration	concentration	NOUN
can-1768	168	18	of	of	ADP
can-1768	168	19	the	the	DET
can-1768	168	20	polymer	polymer	NOUN
can-1768	168	21	existing	exist	VERB
can-1768	168	22	which	which	PRON
can-1768	168	23	impedes	impede	VERB
can-1768	168	24	the	the	DET
can-1768	168	25	drug	drug	NOUN
can-1768	168	26	release	release	NOUN
can-1768	168	27	by	by	ADP
can-1768	168	28	diffusion[26	diffusion[26	NOUN
can-1768	168	29	]	]	PUNCT
can-1768	168	30	.	.	PUNCT
can-1768	169	1	figure	figure	NOUN
can-1768	169	2	13	13	NUM
can-1768	169	3	.	.	PUNCT
can-1768	170	1	in	in	ADP
can-1768	170	2	-	-	PUNCT
can-1768	170	3	vitro	vitro	X
can-1768	170	4	drug	drug	NOUN
can-1768	170	5	release	release	NOUN
can-1768	170	6	study	study	NOUN
can-1768	170	7	of	of	ADP
can-1768	170	8	pure	pure	ADJ
can-1768	170	9	cisplatin	cisplatin	NOUN
can-1768	170	10	and	and	CCONJ
can-1768	170	11	cisplatin	cisplatin	NOUN
can-1768	170	12	plga	plga	PROPN
can-1768	170	13	nps	nps	PROPN
can-1768	170	14	in	in	ADP
can-1768	170	15	pbs	pbs	PROPN
can-1768	170	16	(	(	PUNCT
can-1768	170	17	ph	ph	PROPN
can-1768	170	18	7.4	7.4	NUM
can-1768	170	19	)	)	PUNCT
can-1768	170	20	.	.	PUNCT
can-1768	171	1	4	4	X
can-1768	171	2	.	.	X
can-1768	171	3	conclusion	conclusion	VERB
can-1768	171	4	the	the	DET
can-1768	171	5	cisplatin	cisplatin	NOUN
can-1768	171	6	-	-	PUNCT
can-1768	171	7	loaded	load	VERB
can-1768	171	8	plga	plga	NOUN
can-1768	171	9	nanoparticles	nanoparticle	NOUN
can-1768	171	10	were	be	AUX
can-1768	171	11	made	make	VERB
can-1768	171	12	using	use	VERB
can-1768	171	13	the	the	DET
can-1768	171	14	double	double	ADJ
can-1768	171	15	emulsion	emulsion	NOUN
can-1768	171	16	solvent	solvent	NOUN
can-1768	171	17	evaporation	evaporation	NOUN
can-1768	171	18	process	process	NOUN
can-1768	171	19	.	.	PUNCT
can-1768	172	1	a	a	DET
can-1768	172	2	second	second	ADJ
can-1768	172	3	-	-	PUNCT
can-1768	172	4	order	order	NOUN
can-1768	172	5	model	model	NOUN
can-1768	172	6	was	be	AUX
can-1768	172	7	fitted	fit	VERB
can-1768	172	8	to	to	ADP
can-1768	172	9	the	the	DET
can-1768	172	10	response	response	NOUN
can-1768	172	11	data	datum	NOUN
can-1768	172	12	of	of	ADP
can-1768	172	13	the	the	DET
can-1768	172	14	cisplatin	cisplatin	NOUN
can-1768	172	15	plga	plga	NOUN
can-1768	172	16	nanoparticles	nanoparticle	NOUN
can-1768	172	17	using	use	VERB
can-1768	172	18	the	the	DET
can-1768	172	19	central	central	ADJ
can-1768	172	20	composite	composite	ADJ
can-1768	172	21	rotatable	rotatable	ADJ
can-1768	172	22	design	design	NOUN
can-1768	172	23	–	–	PUNCT
can-1768	172	24	responsive	responsive	ADJ
can-1768	172	25	surface	surface	NOUN
can-1768	172	26	approach	approach	NOUN
can-1768	172	27	.	.	PUNCT
can-1768	173	1	most	most	ADJ
can-1768	173	2	of	of	ADP
can-1768	173	3	the	the	DET
can-1768	173	4	nanoparticles	nanoparticle	NOUN
can-1768	173	5	’	'	PUNCT
can-1768	173	6	experimental	experimental	ADJ
can-1768	173	7	values	value	NOUN
can-1768	173	8	were	be	AUX
can-1768	173	9	in	in	ADP
can-1768	173	10	line	line	NOUN
can-1768	173	11	with	with	ADP
can-1768	173	12	their	their	PRON
can-1768	173	13	projected	project	VERB
can-1768	173	14	values	value	NOUN
can-1768	173	15	.	.	PUNCT
can-1768	174	1	the	the	DET
can-1768	174	2	obtained	obtain	VERB
can-1768	174	3	nanoparticles	nanoparticle	NOUN
can-1768	174	4	were	be	AUX
can-1768	174	5	found	find	VERB
can-1768	174	6	to	to	PART
can-1768	174	7	be	be	AUX
can-1768	174	8	spherical	spherical	ADJ
can-1768	174	9	in	in	ADP
can-1768	174	10	shape	shape	NOUN
can-1768	174	11	confirmed	confirm	VERB
can-1768	174	12	by	by	ADP
can-1768	174	13	scanning	scan	VERB
can-1768	174	14	electron	electron	NOUN
can-1768	174	15	microscopy	microscopy	NOUN
can-1768	174	16	.	.	PUNCT
can-1768	175	1	nanoparticle	nanoparticle	NOUN
can-1768	175	2	-	-	PUNCT
can-1768	175	3	mediated	mediate	VERB
can-1768	175	4	drug	drug	NOUN
can-1768	175	5	release	release	NOUN
can-1768	175	6	followed	follow	VERB
can-1768	175	7	a	a	DET
can-1768	175	8	biphasic	biphasic	ADJ
can-1768	175	9	pattern	pattern	NOUN
can-1768	175	10	,	,	PUNCT
can-1768	175	11	with	with	ADP
can-1768	175	12	early	early	ADJ
can-1768	175	13	burst	burst	ADJ
can-1768	175	14	releases	release	NOUN
can-1768	175	15	followed	follow	VERB
can-1768	175	16	by	by	ADP
can-1768	175	17	a	a	DET
can-1768	175	18	sustained	sustained	ADJ
can-1768	175	19	release	release	NOUN
can-1768	175	20	.	.	PUNCT
can-1768	176	1	in	in	ADP
can-1768	176	2	vitro	vitro	X
can-1768	176	3	drug	drug	NOUN
can-1768	176	4	release	release	NOUN
can-1768	176	5	trials	trial	NOUN
can-1768	176	6	using	use	VERB
can-1768	176	7	nanoparticles	nanoparticle	NOUN
can-1768	176	8	showed	show	VERB
can-1768	176	9	a	a	DET
can-1768	176	10	long	long	ADJ
can-1768	176	11	-	-	PUNCT
can-1768	176	12	term	term	NOUN
can-1768	176	13	effect	effect	NOUN
can-1768	176	14	.	.	PUNCT
can-1768	177	1	according	accord	VERB
can-1768	177	2	to	to	ADP
can-1768	177	3	these	these	DET
can-1768	177	4	findings	finding	NOUN
can-1768	177	5	,	,	PUNCT
can-1768	177	6	the	the	DET
can-1768	177	7	nanoparticles	nanoparticle	NOUN
can-1768	177	8	developed	develop	VERB
can-1768	177	9	in	in	ADP
can-1768	177	10	this	this	DET
can-1768	177	11	work	work	NOUN
can-1768	177	12	might	might	AUX
can-1768	177	13	be	be	AUX
can-1768	177	14	used	use	VERB
can-1768	177	15	therapeutically	therapeutically	ADV
can-1768	177	16	as	as	ADP
can-1768	177	17	a	a	DET
can-1768	177	18	carrier	carrier	NOUN
can-1768	177	19	with	with	ADP
can-1768	177	20	an	an	DET
can-1768	177	21	initial	initial	ADJ
can-1768	177	22	dosage	dosage	NOUN
can-1768	177	23	and	and	CCONJ
can-1768	177	24	a	a	DET
can-1768	177	25	sustained	sustained	ADJ
can-1768	177	26	plasma	plasma	NOUN
can-1768	177	27	level	level	NOUN
can-1768	177	28	in	in	ADP
can-1768	177	29	vivo	vivo	NOUN
can-1768	177	30	.	.	PUNCT
can-1768	178	1	conflict	conflict	NOUN
can-1768	178	2	of	of	ADP
can-1768	178	3	interest	interest	NOUN
can-1768	178	4	the	the	DET
can-1768	178	5	authors	author	NOUN
can-1768	178	6	declare	declare	VERB
can-1768	178	7	that	that	SCONJ
can-1768	178	8	they	they	PRON
can-1768	178	9	have	have	VERB
can-1768	178	10	no	no	DET
can-1768	178	11	conflict	conflict	NOUN
can-1768	178	12	of	of	ADP
can-1768	178	13	interest	interest	NOUN
can-1768	178	14	.	.	PUNCT
can-1768	179	1	references	reference	NOUN
can-1768	179	2	1	1	NUM
can-1768	179	3	.	.	PROPN
can-1768	179	4	attia	attia	PROPN
can-1768	179	5	mf	mf	PROPN
can-1768	179	6	,	,	PUNCT
can-1768	179	7	anton	anton	PROPN
can-1768	179	8	n	n	CCONJ
can-1768	179	9	,	,	PUNCT
can-1768	179	10	wallyn	wallyn	PROPN
can-1768	179	11	j	j	PROPN
can-1768	179	12	,	,	PUNCT
can-1768	179	13	et	et	PROPN
can-1768	179	14	al	al	PROPN
can-1768	179	15	.	.	PUNCT
can-1768	180	1	an	an	DET
can-1768	180	2	overview	overview	NOUN
can-1768	180	3	of	of	ADP
can-1768	180	4	active	active	ADJ
can-1768	180	5	and	and	CCONJ
can-1768	180	6	passive	passive	ADJ
can-1768	180	7	targeting	targeting	NOUN
can-1768	180	8	strategies	strategy	NOUN
can-1768	180	9	to	to	PART
can-1768	180	10	improve	improve	VERB
can-1768	180	11	the	the	DET
can-1768	180	12	nanocarriers	nanocarrier	NOUN
can-1768	180	13	efficiency	efficiency	NOUN
can-1768	180	14	to	to	ADP
can-1768	180	15	tumor	tumor	NOUN
can-1768	180	16	sites	site	NOUN
can-1768	180	17	.	.	PUNCT
can-1768	181	1	journal	journal	NOUN
can-1768	181	2	of	of	ADP
can-1768	181	3	pharmacy	pharmacy	NOUN
can-1768	181	4	and	and	CCONJ
can-1768	181	5	pharmacology	pharmacology	NOUN
can-1768	181	6	2019	2019	NUM
can-1768	181	7	;	;	PUNCT
can-1768	181	8	71(8	71(8	NUM
can-1768	181	9	):	):	PUNCT
can-1768	181	10	1185	1185	NUM
can-1768	181	11	–	–	PUNCT
can-1768	181	12	1198	1198	NUM
can-1768	181	13	.	.	PUNCT
can-1768	182	1	2	2	X
can-1768	182	2	.	.	X
can-1768	182	3	danaei	danaei	PROPN
can-1768	182	4	m	m	PROPN
can-1768	182	5	,	,	PUNCT
can-1768	182	6	dehghankhold	dehghankhold	VERB
can-1768	182	7	m	m	PRON
can-1768	182	8	,	,	PUNCT
can-1768	182	9	ataei	ataei	PROPN
can-1768	182	10	s	s	PART
can-1768	182	11	,	,	PUNCT
can-1768	183	1	et	et	PROPN
can-1768	183	2	al	al	PROPN
can-1768	183	3	.	.	PROPN
can-1768	183	4	impact	impact	NOUN
can-1768	183	5	of	of	ADP
can-1768	183	6	particle	particle	NOUN
can-1768	183	7	size	size	NOUN
can-1768	183	8	and	and	CCONJ
can-1768	183	9	polydispersity	polydispersity	NOUN
can-1768	183	10	index	index	NOUN
can-1768	183	11	on	on	ADP
can-1768	183	12	the	the	DET
can-1768	183	13	clinical	clinical	ADJ
can-1768	183	14	applications	application	NOUN
can-1768	183	15	of	of	ADP
can-1768	183	16	lipidic	lipidic	ADJ
can-1768	183	17	nanocarrier	nanocarrier	PROPN
can-1768	183	18	systems	systems	PROPN
can-1768	183	19	.	.	PUNCT
can-1768	184	1	pharmaceutics	pharmaceutic	NOUN
can-1768	184	2	2018	2018	NUM
can-1768	184	3	;	;	PUNCT
can-1768	184	4	10(2	10(2	NUM
can-1768	184	5	):	):	PUNCT
can-1768	184	6	57	57	NUM
can-1768	184	7	.	.	X
can-1768	184	8	3	3	X
can-1768	184	9	.	.	X
can-1768	184	10	shehata	shehata	PROPN
can-1768	184	11	t	t	PROPN
can-1768	184	12	,	,	PUNCT
can-1768	184	13	kimura	kimura	PROPN
can-1768	184	14	t	t	PROPN
can-1768	184	15	,	,	PUNCT
can-1768	184	16	higaki	higaki	PROPN
can-1768	184	17	k	k	PROPN
can-1768	184	18	,	,	PUNCT
can-1768	184	19	et	et	PROPN
can-1768	184	20	al	al	PROPN
can-1768	184	21	.	.	PROPN
can-1768	184	22	in	in	ADP
can-1768	184	23	-	-	PUNCT
can-1768	184	24	vivo	vivo	NOUN
can-1768	184	25	disposition	disposition	NOUN
can-1768	184	26	characteristics	characteristic	NOUN
can-1768	184	27	of	of	ADP
can-1768	184	28	peg	peg	NOUN
can-1768	184	29	niosome	niosome	NOUN
can-1768	184	30	and	and	CCONJ
can-1768	184	31	its	its	PRON
can-1768	184	32	interaction	interaction	NOUN
can-1768	184	33	with	with	ADP
can-1768	184	34	serum	serum	NOUN
can-1768	184	35	proteins	protein	NOUN
can-1768	184	36	.	.	PUNCT
can-1768	185	1	international	international	ADJ
can-1768	185	2	journal	journal	PROPN
can-1768	185	3	of	of	ADP
can-1768	185	4	pharmaceutics	pharmaceutic	NOUN
can-1768	185	5	2016	2016	NUM
can-1768	185	6	;	;	PUNCT
can-1768	185	7	512(1	512(1	NUM
can-1768	185	8	):	):	PUNCT
can-1768	185	9	322–328	322–328	NUM
can-1768	185	10	.	.	PUNCT
can-1768	186	1	4	4	X
can-1768	186	2	.	.	X
can-1768	186	3	kreuter	kreuter	PROPN
can-1768	186	4	j	j	PROPN
can-1768	186	5	,	,	PUNCT
can-1768	186	6	hekmatara	hekmatara	PROPN
can-1768	186	7	t	t	PROPN
can-1768	186	8	,	,	PUNCT
can-1768	186	9	dreis	dreis	PROPN
can-1768	186	10	s	s	PROPN
can-1768	186	11	,	,	PUNCT
can-1768	186	12	et	et	PROPN
can-1768	186	13	al	al	PROPN
can-1768	186	14	.	.	PROPN
can-1768	186	15	covalent	covalent	ADJ
can-1768	186	16	attachment	attachment	NOUN
can-1768	186	17	of	of	ADP
can-1768	186	18	apolipoprotein	apolipoprotein	ADJ
can-1768	186	19	ai	ai	PROPN
can-1768	186	20	and	and	CCONJ
can-1768	186	21	apolipoprotein	apolipoprotein	ADJ
can-1768	186	22	b-100	b-100	ADP
can-1768	186	23	to	to	ADP
can-1768	186	24	albumin	albumin	ADJ
can-1768	186	25	nanoparticles	nanoparticle	NOUN
can-1768	186	26	enables	enable	VERB
can-1768	186	27	drug	drug	NOUN
can-1768	186	28	transport	transport	NOUN
can-1768	186	29	into	into	ADP
can-1768	186	30	the	the	DET
can-1768	186	31	brain	brain	NOUN
can-1768	186	32	.	.	PUNCT
can-1768	187	1	journal	journal	PROPN
can-1768	187	2	of	of	ADP
can-1768	187	3	controlled	control	VERB
can-1768	187	4	release	release	NOUN
can-1768	187	5	2007	2007	NUM
can-1768	187	6	;	;	PUNCT
can-1768	187	7	118(1	118(1	NUM
can-1768	187	8	):	):	PUNCT
can-1768	187	9	54–58	54–58	NUM
can-1768	187	10	.	.	PUNCT
can-1768	188	1	5	5	NUM
can-1768	188	2	.	.	X
can-1768	188	3	jiang	jiang	PROPN
can-1768	188	4	w	w	PROPN
can-1768	188	5	,	,	PUNCT
can-1768	188	6	kim	kim	PROPN
can-1768	188	7	bys	bys	PROPN
can-1768	188	8	,	,	PUNCT
can-1768	188	9	rutka	rutka	PROPN
can-1768	188	10	jt	jt	PROPN
can-1768	188	11	,	,	PUNCT
can-1768	188	12	et	et	PROPN
can-1768	188	13	al	al	PROPN
can-1768	188	14	.	.	PROPN
can-1768	188	15	advances	advance	NOUN
can-1768	188	16	and	and	CCONJ
can-1768	188	17	challenges	challenge	NOUN
can-1768	188	18	of	of	ADP
can-1768	188	19	nanotechnology	nanotechnology	NOUN
can-1768	188	20	-	-	PUNCT
can-1768	188	21	based	base	VERB
can-1768	188	22	drug	drug	NOUN
can-1768	188	23	delivery	delivery	NOUN
can-1768	188	24	systems	system	NOUN
can-1768	188	25	.	.	PUNCT
can-1768	189	1	expert	expert	ADJ
can-1768	189	2	opinion	opinion	NOUN
can-1768	189	3	on	on	ADP
can-1768	189	4	drug	drug	NOUN
can-1768	189	5	delivery	delivery	NOUN
can-1768	189	6	2007	2007	NUM
can-1768	189	7	;	;	PUNCT
can-1768	189	8	4(6	4(6	NUM
can-1768	189	9	):	):	PUNCT
can-1768	189	10	621–633	621–633	NUM
can-1768	189	11	.	.	PUNCT
can-1768	190	1	6	6	NUM
can-1768	190	2	.	.	X
can-1768	190	3	lövestam	lövestam	NOUN
can-1768	190	4	g	g	PROPN
can-1768	190	5	,	,	PUNCT
can-1768	190	6	rauscher	rauscher	NOUN
can-1768	190	7	h	h	NOUN
can-1768	190	8	,	,	PUNCT
can-1768	190	9	roebben	roebben	VERB
can-1768	190	10	g	g	PROPN
can-1768	190	11	,	,	PUNCT
can-1768	190	12	et	et	PROPN
can-1768	190	13	al	al	PROPN
can-1768	190	14	.	.	PUNCT
can-1768	191	1	considerations	consideration	NOUN
can-1768	191	2	on	on	ADP
can-1768	191	3	a	a	DET
can-1768	191	4	definition	definition	NOUN
can-1768	191	5	of	of	ADP
can-1768	191	6	nanomaterial	nanomaterial	NOUN
can-1768	191	7	for	for	ADP
can-1768	191	8	regulatory	regulatory	ADJ
can-1768	191	9	purposes	purpose	NOUN
can-1768	191	10	.	.	PUNCT
can-1768	192	1	joint	joint	ADJ
can-1768	192	2	research	research	NOUN
can-1768	192	3	centre	centre	PROPN
can-1768	192	4	(	(	PUNCT
can-1768	192	5	jrc	jrc	PROPN
can-1768	192	6	)	)	PUNCT
can-1768	192	7	reference	reference	NOUN
can-1768	192	8	reports	report	VERB
can-1768	192	9	.	.	PUNCT
can-1768	193	1	luxembourg	luxembourg	PROPN
can-1768	193	2	:	:	PUNCT
can-1768	193	3	publications	publication	NOUN
can-1768	193	4	office	office	NOUN
can-1768	193	5	of	of	ADP
can-1768	193	6	the	the	DET
can-1768	193	7	european	european	PROPN
can-1768	193	8	union	union	PROPN
can-1768	193	9	;	;	PUNCT
can-1768	193	10	2010	2010	NUM
can-1768	193	11	.	.	PUNCT
can-1768	194	1	p.	p.	NOUN
can-1768	194	2	00–41	00–41	NUM
can-1768	194	3	.	.	PUNCT
can-1768	195	1	7	7	X
can-1768	195	2	.	.	X
can-1768	195	3	zeng	zeng	PROPN
can-1768	195	4	x	x	PROPN
can-1768	195	5	,	,	PUNCT
can-1768	195	6	tao	tao	PROPN
can-1768	195	7	w	w	PROPN
can-1768	195	8	,	,	PUNCT
can-1768	195	9	wang	wang	PROPN
can-1768	195	10	z	z	PROPN
can-1768	195	11	,	,	PUNCT
can-1768	195	12	et	et	PROPN
can-1768	195	13	al	al	PROPN
can-1768	195	14	.	.	PROPN
can-1768	195	15	docetaxel	docetaxel	PROPN
can-1768	195	16	-	-	PUNCT
can-1768	195	17	loaded	load	VERB
can-1768	195	18	nanoparticles	nanoparticle	NOUN
can-1768	195	19	of	of	ADP
can-1768	195	20	dendritic	dendritic	ADJ
can-1768	195	21	amphiphilic	amphiphilic	ADJ
can-1768	195	22	block	block	NOUN
can-1768	195	23	copolymer	copolymer	NOUN
can-1768	195	24	h40	h40	PROPN
can-1768	195	25	-	-	PUNCT
can-1768	195	26	pla	pla	NOUN
can-1768	195	27	-	-	PUNCT
can-1768	195	28	b	b	NOUN
can-1768	195	29	-	-	PUNCT
can-1768	195	30	tpgs	tpgs	NOUN
can-1768	195	31	for	for	ADP
can-1768	195	32	cancer	cancer	NOUN
can-1768	195	33	treatment	treatment	NOUN
can-1768	195	34	.	.	PUNCT
can-1768	196	1	particle	particle	PROPN
can-1768	196	2	&	&	CCONJ
can-1768	196	3	particle	particle	NOUN
can-1768	196	4	systems	system	NOUN
can-1768	196	5	characterization	characterization	NOUN
can-1768	196	6	2015	2015	NUM
can-1768	196	7	;	;	PUNCT
can-1768	196	8	32(1	32(1	NUM
can-1768	196	9	):	):	PUNCT
can-1768	196	10	112–122	112–122	NUM
can-1768	196	11	.	.	NOUN
can-1768	196	12	8	8	NUM
can-1768	196	13	.	.	NOUN
can-1768	196	14	venkatasubbu	venkatasubbu	NOUN
can-1768	196	15	gd	gd	PROPN
can-1768	196	16	,	,	PUNCT
can-1768	196	17	ramasamy	ramasamy	NOUN
can-1768	196	18	s	s	PROPN
can-1768	196	19	,	,	PUNCT
can-1768	196	20	avadhani	avadhani	PROPN
can-1768	196	21	gs	gs	PROPN
can-1768	196	22	,	,	PUNCT
can-1768	196	23	et	et	PROPN
can-1768	196	24	al	al	PROPN
can-1768	196	25	.	.	PROPN
can-1768	196	26	surface	surface	PROPN
can-1768	196	27	modification	modification	NOUN
can-1768	196	28	and	and	CCONJ
can-1768	196	29	paclitaxel	paclitaxel	VERB
can-1768	196	30	drug	drug	NOUN
can-1768	196	31	delivery	delivery	NOUN
can-1768	196	32	of	of	ADP
can-1768	196	33	folic	folic	ADJ
can-1768	196	34	acid	acid	NOUN
can-1768	196	35	modified	modify	VERB
can-1768	196	36	polyethylene	polyethylene	NOUN
can-1768	196	37	glycol	glycol	NOUN
can-1768	196	38	functionalized	functionalize	VERB
can-1768	196	39	hydroxyapatite	hydroxyapatite	NOUN
can-1768	196	40	nanoparticles	nanoparticle	NOUN
can-1768	196	41	.	.	PUNCT
can-1768	197	1	powder	powder	NOUN
can-1768	197	2	technology	technology	NOUN
can-1768	197	3	2013	2013	NUM
can-1768	197	4	;	;	PUNCT
can-1768	197	5	235	235	NUM
can-1768	197	6	:	:	PUNCT
can-1768	197	7	437–442	437–442	NUM
can-1768	197	8	.	.	PUNCT
can-1768	198	1	9	9	NUM
can-1768	198	2	.	.	X
can-1768	198	3	yang	yang	PROPN
can-1768	198	4	s	s	PROPN
can-1768	198	5	,	,	PUNCT
can-1768	198	6	zhou	zhou	PROPN
can-1768	198	7	l	l	PROPN
can-1768	198	8	,	,	PUNCT
can-1768	198	9	su	su	PROPN
can-1768	198	10	y	y	PROPN
can-1768	198	11	,	,	PUNCT
can-1768	198	12	et	et	PROPN
can-1768	198	13	al	al	PROPN
can-1768	198	14	.	.	PROPN
can-1768	199	1	one	one	NUM
can-1768	199	2	-	-	PUNCT
can-1768	199	3	pot	pot	NOUN
can-1768	199	4	photoreduction	photoreduction	NOUN
can-1768	199	5	to	to	PART
can-1768	199	6	prepare	prepare	VERB
can-1768	199	7	nir	nir	ADJ
can-1768	199	8	-	-	PUNCT
can-1768	199	9	absorbing	absorbing	ADJ
can-1768	199	10	plasmonic	plasmonic	NOUN
can-1768	199	11	gold	gold	NOUN
can-1768	199	12	nanoparticles	nanoparticle	NOUN
can-1768	199	13	tethered	tether	VERB
can-1768	199	14	by	by	ADP
can-1768	199	15	amphiphilic	amphiphilic	ADJ
can-1768	199	16	polypeptide	polypeptide	ADJ
can-1768	199	17	copolymer	copolymer	NOUN
can-1768	199	18	for	for	ADP
can-1768	199	19	synergistic	synergistic	ADJ
can-1768	199	20	photothermalchemotherapy	photothermalchemotherapy	NOUN
can-1768	199	21	.	.	PUNCT
can-1768	200	1	chinese	chinese	ADJ
can-1768	200	2	chemical	chemical	ADJ
can-1768	200	3	letters	letter	NOUN
can-1768	200	4	2019	2019	NUM
can-1768	200	5	;	;	PUNCT
can-1768	200	6	30(1	30(1	NUM
can-1768	200	7	):	):	PUNCT
can-1768	200	8	187–191	187–191	NUM
can-1768	200	9	.	.	PUNCT
can-1768	201	1	110	110	NUM
can-1768	201	2	10	10	NUM
can-1768	201	3	.	.	PUNCT
can-1768	202	1	peng	peng	PROPN
can-1768	202	2	y	y	PROPN
can-1768	202	3	,	,	PUNCT
can-1768	202	4	nie	nie	PROPN
can-1768	202	5	j	j	PROPN
can-1768	202	6	,	,	PUNCT
can-1768	202	7	cheng	cheng	PROPN
can-1768	202	8	w	w	PROPN
can-1768	202	9	,	,	PUNCT
can-1768	202	10	et	et	PROPN
can-1768	202	11	al	al	PROPN
can-1768	202	12	.	.	PUNCT
can-1768	203	1	a	a	DET
can-1768	203	2	multifunctional	multifunctional	ADJ
can-1768	203	3	nanoplatform	nanoplatform	NOUN
can-1768	203	4	for	for	ADP
can-1768	203	5	cancer	cancer	NOUN
can-1768	203	6	chemo	chemo	NOUN
can-1768	203	7	-	-	PUNCT
can-1768	203	8	photothermal	photothermal	ADJ
can-1768	203	9	synergistic	synergistic	ADJ
can-1768	203	10	therapy	therapy	NOUN
can-1768	203	11	and	and	CCONJ
can-1768	203	12	overcoming	overcome	VERB
can-1768	203	13	multidrug	multidrug	NOUN
can-1768	203	14	resistance	resistance	NOUN
can-1768	203	15	.	.	PUNCT
can-1768	204	1	biomaterials	biomaterial	NOUN
can-1768	204	2	science	science	NOUN
can-1768	204	3	2018	2018	NUM
can-1768	204	4	;	;	PUNCT
can-1768	204	5	6(5	6(5	NUM
can-1768	204	6	):	):	PUNCT
can-1768	204	7	1084–1098	1084–1098	NUM
can-1768	204	8	.	.	PUNCT
can-1768	204	9	11	11	NUM
can-1768	204	10	.	.	X
can-1768	205	1	reis	reis	NOUN
can-1768	205	2	cp	cp	PROPN
can-1768	205	3	,	,	PUNCT
can-1768	205	4	neufeld	neufeld	PROPN
can-1768	205	5	rj	rj	PROPN
can-1768	205	6	,	,	PUNCT
can-1768	205	7	ribeiro	ribeiro	PROPN
can-1768	205	8	aj	aj	PROPN
can-1768	205	9	,	,	PUNCT
can-1768	205	10	et	et	PROPN
can-1768	205	11	al	al	PROPN
can-1768	205	12	.	.	PUNCT
can-1768	206	1	nanoencapsulation	nanoencapsulation	NOUN
can-1768	207	1	i	i	PRON
can-1768	207	2	:	:	PUNCT
can-1768	207	3	methods	method	NOUN
can-1768	207	4	for	for	ADP
can-1768	207	5	preparation	preparation	NOUN
can-1768	207	6	of	of	ADP
can-1768	207	7	drug	drug	NOUN
can-1768	207	8	-	-	PUNCT
can-1768	207	9	loaded	load	VERB
can-1768	207	10	polymeric	polymeric	ADJ
can-1768	207	11	nanoparticles	nanoparticle	NOUN
can-1768	207	12	.	.	PUNCT
can-1768	208	1	nanomedicine	nanomedicine	NOUN
can-1768	208	2	:	:	PUNCT
can-1768	208	3	nanotechnology	nanotechnology	NOUN
can-1768	208	4	,	,	PUNCT
can-1768	208	5	biology	biology	NOUN
can-1768	208	6	and	and	CCONJ
can-1768	208	7	medicine	medicine	NOUN
can-1768	208	8	2006	2006	NUM
can-1768	208	9	;	;	PUNCT
can-1768	208	10	2(1	2(1	NUM
can-1768	208	11	):	):	PUNCT
can-1768	208	12	8–21	8–21	NOUN
can-1768	208	13	.	.	PUNCT
can-1768	209	1	12	12	NUM
can-1768	209	2	.	.	PUNCT
can-1768	210	1	rao	rao	PROPN
can-1768	210	2	jp	jp	PROPN
can-1768	210	3	,	,	PUNCT
can-1768	210	4	geckeler	geckeler	PROPN
can-1768	210	5	ke	ke	PROPN
can-1768	210	6	.	.	PUNCT
can-1768	211	1	polymer	polymer	NOUN
can-1768	211	2	nanoparticles	nanoparticle	NOUN
can-1768	211	3	:	:	PUNCT
can-1768	211	4	preparation	preparation	NOUN
can-1768	211	5	techniques	technique	NOUN
can-1768	211	6	and	and	CCONJ
can-1768	211	7	size	size	NOUN
can-1768	211	8	-	-	PUNCT
can-1768	211	9	control	control	NOUN
can-1768	211	10	parameters	parameter	NOUN
can-1768	211	11	.	.	PUNCT
can-1768	212	1	progress	progress	NOUN
can-1768	212	2	in	in	ADP
can-1768	212	3	polymer	polymer	NOUN
can-1768	212	4	science	science	NOUN
can-1768	212	5	2011	2011	NUM
can-1768	212	6	;	;	PUNCT
can-1768	212	7	36(7	36(7	NUM
can-1768	212	8	):	):	PUNCT
can-1768	212	9	887–913	887–913	NUM
can-1768	212	10	.	.	PUNCT
can-1768	213	1	13	13	NUM
can-1768	213	2	.	.	PUNCT
can-1768	213	3	pal	pal	PROPN
can-1768	213	4	sl	sl	PROPN
can-1768	213	5	,	,	PUNCT
can-1768	213	6	jana	jana	PROPN
can-1768	213	7	u	u	PROPN
can-1768	213	8	,	,	PUNCT
can-1768	213	9	manna	manna	PROPN
can-1768	213	10	pk	pk	PROPN
can-1768	213	11	,	,	PUNCT
can-1768	213	12	et	et	PROPN
can-1768	213	13	al	al	PROPN
can-1768	213	14	.	.	PROPN
can-1768	213	15	nanoparticle	nanoparticle	PROPN
can-1768	213	16	:	:	PUNCT
can-1768	213	17	an	an	DET
can-1768	213	18	overview	overview	NOUN
can-1768	213	19	of	of	ADP
can-1768	213	20	preparation	preparation	NOUN
can-1768	213	21	and	and	CCONJ
can-1768	213	22	characterization	characterization	NOUN
can-1768	213	23	.	.	PUNCT
can-1768	214	1	journal	journal	NOUN
can-1768	214	2	of	of	ADP
can-1768	214	3	applied	apply	VERB
can-1768	214	4	pharmaceutical	pharmaceutical	ADJ
can-1768	214	5	science	science	NOUN
can-1768	214	6	2011	2011	NUM
can-1768	214	7	;	;	PUNCT
can-1768	214	8	1(6	1(6	NUM
can-1768	214	9	):	):	PUNCT
can-1768	214	10	228–234	228–234	NUM
can-1768	214	11	.	.	PUNCT
can-1768	214	12	14	14	NUM
can-1768	214	13	.	.	PUNCT
can-1768	215	1	vaughn	vaughn	PROPN
can-1768	215	2	dj	dj	PROPN
can-1768	215	3	.	.	PROPN
can-1768	215	4	paclitaxel	paclitaxel	PROPN
can-1768	215	5	and	and	CCONJ
can-1768	215	6	carboplatin	carboplatin	NOUN
can-1768	215	7	in	in	ADP
can-1768	215	8	bladder	bladder	NOUN
can-1768	215	9	cancer	cancer	NOUN
can-1768	215	10	:	:	PUNCT
can-1768	215	11	recent	recent	ADJ
can-1768	215	12	developments	development	NOUN
can-1768	215	13	.	.	PUNCT
can-1768	216	1	european	european	ADJ
can-1768	216	2	journal	journal	PROPN
can-1768	216	3	of	of	ADP
can-1768	216	4	cancer	cancer	NOUN
can-1768	216	5	2000	2000	NUM
can-1768	216	6	;	;	PUNCT
can-1768	216	7	36	36	NUM
can-1768	216	8	:	:	PUNCT
can-1768	216	9	7–12	7–12	NUM
can-1768	216	10	.	.	PUNCT
can-1768	217	1	15	15	NUM
can-1768	217	2	.	.	PUNCT
can-1768	217	3	yan	yan	PROPN
can-1768	218	1	x	x	SYM
can-1768	218	2	,	,	PUNCT
can-1768	218	3	gemeinhart	gemeinhart	PROPN
can-1768	218	4	r	r	NOUN
can-1768	218	5	a.	a.	NOUN
can-1768	218	6	cisplatin	cisplatin	NOUN
can-1768	218	7	delivery	delivery	NOUN
can-1768	218	8	from	from	ADP
can-1768	218	9	poly	poly	ADJ
can-1768	218	10	(	(	PUNCT
can-1768	218	11	acrylic	acrylic	NOUN
can-1768	218	12	acid	acid	NOUN
can-1768	218	13	-	-	PUNCT
can-1768	218	14	co	co	NOUN
can-1768	218	15	-	-	ADJ
can-1768	218	16	methyl	methyl	ADJ
can-1768	218	17	methacrylate	methacrylate	NOUN
can-1768	218	18	)	)	PUNCT
can-1768	218	19	microparticles	microparticle	NOUN
can-1768	218	20	.	.	PUNCT
can-1768	219	1	journal	journal	PROPN
can-1768	219	2	of	of	ADP
can-1768	219	3	controlled	control	VERB
can-1768	219	4	release	release	NOUN
can-1768	219	5	2005	2005	NUM
can-1768	219	6	;	;	PUNCT
can-1768	219	7	106(1–2	106(1–2	NUM
can-1768	219	8	):	):	PUNCT
can-1768	219	9	198–208	198–208	NUM
can-1768	219	10	.	.	PUNCT
can-1768	219	11	16	16	NUM
can-1768	219	12	.	.	PUNCT
can-1768	220	1	cvitkovic	cvitkovic	PROPN
can-1768	220	2	e.	e.	PROPN
can-1768	220	3	cumulative	cumulative	PROPN
can-1768	220	4	toxicities	toxicity	NOUN
can-1768	220	5	from	from	ADP
can-1768	220	6	cisplatin	cisplatin	NOUN
can-1768	220	7	therapy	therapy	NOUN
can-1768	220	8	and	and	CCONJ
can-1768	220	9	current	current	ADJ
can-1768	220	10	cytoprotective	cytoprotective	ADJ
can-1768	220	11	measures	measure	NOUN
can-1768	220	12	.	.	PUNCT
can-1768	221	1	cancer	cancer	NOUN
can-1768	221	2	treatment	treatment	NOUN
can-1768	221	3	reviews	review	NOUN
can-1768	221	4	1998	1998	NUM
can-1768	221	5	;	;	PUNCT
can-1768	221	6	24(4	24(4	NUM
can-1768	221	7	):	):	PUNCT
can-1768	221	8	265–281	265–281	NUM
can-1768	221	9	.	.	PUNCT
can-1768	222	1	17	17	NUM
can-1768	222	2	.	.	PUNCT
can-1768	223	1	van	van	PROPN
can-1768	223	2	leeuwen	leeuwen	PROPN
can-1768	223	3	bl	bl	PROPN
can-1768	223	4	,	,	PUNCT
can-1768	223	5	kamps	kamps	PROPN
can-1768	223	6	wa	wa	PROPN
can-1768	223	7	,	,	PUNCT
can-1768	223	8	jansen	jansen	PROPN
can-1768	223	9	hwb	hwb	PROPN
can-1768	223	10	,	,	PUNCT
can-1768	223	11	et	et	PROPN
can-1768	223	12	al	al	PROPN
can-1768	223	13	.	.	PUNCT
can-1768	224	1	the	the	DET
can-1768	224	2	effect	effect	NOUN
can-1768	224	3	of	of	ADP
can-1768	224	4	chemotherapy	chemotherapy	NOUN
can-1768	224	5	on	on	ADP
can-1768	224	6	the	the	DET
can-1768	224	7	growing	grow	VERB
can-1768	224	8	skeleton	skeleton	NOUN
can-1768	224	9	.	.	PUNCT
can-1768	225	1	cancer	cancer	NOUN
can-1768	225	2	treatment	treatment	NOUN
can-1768	225	3	reviews	review	NOUN
can-1768	225	4	2000	2000	NUM
can-1768	225	5	;	;	PUNCT
can-1768	225	6	26(5	26(5	NUM
can-1768	225	7	):	):	PUNCT
can-1768	225	8	363	363	NUM
can-1768	225	9	–	–	PUNCT
can-1768	225	10	376	376	NUM
can-1768	225	11	.	.	PUNCT
can-1768	225	12	18	18	NUM
can-1768	225	13	.	.	PUNCT
can-1768	226	1	gamal	gamal	PROPN
can-1768	226	2	eid	eid	PROPN
can-1768	226	3	a	a	PROPN
can-1768	226	4	,	,	PUNCT
can-1768	226	5	uddin	uddin	PROPN
can-1768	226	6	n	n	CCONJ
can-1768	226	7	,	,	PUNCT
can-1768	226	8	girgis	girgis	ADJ
can-1768	226	9	s.	s.	PROPN
can-1768	226	10	formulation	formulation	NOUN
can-1768	226	11	and	and	CCONJ
can-1768	226	12	optimization	optimization	NOUN
can-1768	226	13	of	of	ADP
can-1768	226	14	biodegradable	biodegradable	ADJ
can-1768	226	15	insulin	insulin	NOUN
can-1768	226	16	loaded	load	VERB
can-1768	226	17	nanoparticles	nanoparticle	NOUN
can-1768	226	18	.	.	PUNCT
can-1768	227	1	european	european	ADJ
can-1768	227	2	journal	journal	PROPN
can-1768	227	3	of	of	ADP
can-1768	227	4	biotechnology	biotechnology	NOUN
can-1768	227	5	and	and	CCONJ
can-1768	227	6	bioscience	bioscience	NOUN
can-1768	227	7	2019	2019	NUM
can-1768	227	8	;	;	PUNCT
can-1768	227	9	7(4	7(4	NUM
can-1768	227	10	):	):	PUNCT
can-1768	227	11	10–21	10–21	NUM
can-1768	227	12	.	.	PUNCT
can-1768	228	1	19	19	NUM
can-1768	228	2	.	.	PUNCT
can-1768	229	1	zhang	zhang	PROPN
can-1768	229	2	x	x	PROPN
can-1768	229	3	,	,	PUNCT
can-1768	229	4	liu	liu	PROPN
can-1768	229	5	j	j	PROPN
can-1768	229	6	,	,	PUNCT
can-1768	229	7	qiao	qiao	PROPN
can-1768	229	8	h	h	PROPN
can-1768	229	9	,	,	PUNCT
can-1768	229	10	et	et	PROPN
can-1768	229	11	al	al	PROPN
can-1768	229	12	.	.	PUNCT
can-1768	229	13	formulation	formulation	NOUN
can-1768	229	14	optimization	optimization	NOUN
can-1768	229	15	of	of	ADP
can-1768	229	16	dihydroartemisinin	dihydroartemisinin	NOUN
can-1768	229	17	nanostructured	nanostructure	VERB
can-1768	229	18	lipid	lipid	NOUN
can-1768	229	19	carrier	carrier	NOUN
can-1768	229	20	using	use	VERB
can-1768	229	21	response	response	NOUN
can-1768	229	22	surface	surface	NOUN
can-1768	229	23	methodology	methodology	NOUN
can-1768	229	24	.	.	PUNCT
can-1768	230	1	powder	powder	NOUN
can-1768	230	2	technology	technology	NOUN
can-1768	230	3	2010	2010	NUM
can-1768	230	4	;	;	PUNCT
can-1768	230	5	197(1–2	197(1–2	NUM
can-1768	230	6	):	):	PUNCT
can-1768	230	7	120–128	120–128	NUM
can-1768	230	8	.	.	PUNCT
can-1768	231	1	20	20	NUM
can-1768	231	2	.	.	PUNCT
can-1768	232	1	avgoustakis	avgoustaki	NOUN
can-1768	232	2	k	k	PROPN
can-1768	232	3	,	,	PUNCT
can-1768	232	4	beletsi	beletsi	PROPN
can-1768	232	5	a	a	PRON
can-1768	232	6	,	,	PUNCT
can-1768	232	7	panagi	panagi	PROPN
can-1768	232	8	z	z	PROPN
can-1768	232	9	,	,	PUNCT
can-1768	232	10	et	et	PROPN
can-1768	232	11	al	al	PROPN
can-1768	232	12	.	.	PROPN
can-1768	232	13	plga	plga	PROPN
can-1768	232	14	–	–	PUNCT
can-1768	232	15	mpeg	mpeg	NOUN
can-1768	232	16	nanoparticles	nanoparticle	NOUN
can-1768	232	17	of	of	ADP
can-1768	232	18	cisplatin	cisplatin	NOUN
can-1768	232	19	:	:	PUNCT
can-1768	232	20	in	in	ADP
can-1768	232	21	vitro	vitro	X
can-1768	232	22	nanoparticle	nanoparticle	NOUN
can-1768	232	23	degradation	degradation	NOUN
can-1768	232	24	,	,	PUNCT
can-1768	232	25	in	in	ADP
can-1768	232	26	vitro	vitro	X
can-1768	232	27	drug	drug	NOUN
can-1768	232	28	release	release	NOUN
can-1768	232	29	and	and	CCONJ
can-1768	232	30	in	in	ADP
can-1768	232	31	vivo	vivo	ADJ
can-1768	232	32	drug	drug	NOUN
can-1768	232	33	residence	residence	NOUN
can-1768	232	34	in	in	ADP
can-1768	232	35	blood	blood	NOUN
can-1768	232	36	properties	property	NOUN
can-1768	232	37	.	.	PUNCT
can-1768	233	1	journal	journal	PROPN
can-1768	233	2	of	of	ADP
can-1768	233	3	controlled	control	VERB
can-1768	233	4	release	release	NOUN
can-1768	233	5	2002	2002	NUM
can-1768	233	6	;	;	PUNCT
can-1768	233	7	79(1–3	79(1–3	NUM
can-1768	233	8	):	):	PUNCT
can-1768	233	9	123–135	123–135	NUM
can-1768	233	10	.	.	PUNCT
can-1768	234	1	21	21	NUM
can-1768	234	2	.	.	PUNCT
can-1768	235	1	agrahari	agrahari	PROPN
can-1768	235	2	v	v	PROPN
can-1768	235	3	,	,	PUNCT
can-1768	235	4	kabra	kabra	NOUN
can-1768	235	5	v	v	NOUN
can-1768	235	6	,	,	PUNCT
can-1768	235	7	trivedi	trivedi	PROPN
can-1768	235	8	p.	p.	PROPN
can-1768	235	9	development	development	PROPN
can-1768	235	10	,	,	PUNCT
can-1768	235	11	optimization	optimization	NOUN
can-1768	235	12	and	and	CCONJ
can-1768	235	13	characterization	characterization	NOUN
can-1768	235	14	of	of	ADP
can-1768	235	15	nanoparticle	nanoparticle	NOUN
can-1768	235	16	drug	drug	NOUN
can-1768	235	17	delivery	delivery	NOUN
can-1768	235	18	system	system	NOUN
can-1768	235	19	of	of	ADP
can-1768	235	20	cisplatin	cisplatin	NOUN
can-1768	235	21	.	.	PUNCT
can-1768	236	1	13th	13th	ADJ
can-1768	236	2	international	international	ADJ
can-1768	236	3	conference	conference	NOUN
can-1768	236	4	on	on	ADP
can-1768	236	5	biomedical	biomedical	ADJ
can-1768	236	6	engineering	engineering	NOUN
can-1768	236	7	;	;	PUNCT
can-1768	236	8	2008	2008	NUM
can-1768	236	9	dec	dec	PROPN
can-1768	236	10	3–6	3–6	NUM
can-1768	236	11	;	;	PUNCT
can-1768	236	12	singapore	singapore	PROPN
can-1768	236	13	.	.	PUNCT
can-1768	237	1	heidelberg	heidelberg	PROPN
can-1768	237	2	:	:	PUNCT
can-1768	237	3	springer	springer	NOUN
can-1768	237	4	;	;	PUNCT
can-1768	237	5	2009	2009	NUM
can-1768	237	6	.	.	PUNCT
can-1768	238	1	p.	p.	NOUN
can-1768	238	2	1325–1328	1325–1328	NUM
can-1768	238	3	.	.	PUNCT
can-1768	239	1	22	22	NUM
can-1768	239	2	.	.	PUNCT
can-1768	240	1	zhang	zhang	PROPN
can-1768	240	2	x	x	PROPN
can-1768	240	3	,	,	PUNCT
can-1768	240	4	liu	liu	PROPN
can-1768	240	5	j	j	PROPN
can-1768	240	6	,	,	PUNCT
can-1768	240	7	qiao	qiao	PROPN
can-1768	240	8	h	h	PROPN
can-1768	240	9	,	,	PUNCT
can-1768	240	10	et	et	PROPN
can-1768	240	11	al	al	PROPN
can-1768	240	12	.	.	PUNCT
can-1768	240	13	formulation	formulation	NOUN
can-1768	240	14	optimization	optimization	NOUN
can-1768	240	15	of	of	ADP
can-1768	240	16	dihydroartemisinin	dihydroartemisinin	NOUN
can-1768	240	17	nanostructured	nanostructure	VERB
can-1768	240	18	lipid	lipid	NOUN
can-1768	240	19	carrier	carrier	NOUN
can-1768	240	20	using	use	VERB
can-1768	240	21	response	response	NOUN
can-1768	240	22	surface	surface	NOUN
can-1768	240	23	methodology	methodology	NOUN
can-1768	240	24	.	.	PUNCT
can-1768	241	1	powder	powder	NOUN
can-1768	241	2	technology	technology	NOUN
can-1768	241	3	2010	2010	NUM
can-1768	241	4	;	;	PUNCT
can-1768	241	5	197(1–2	197(1–2	NUM
can-1768	241	6	):	):	PUNCT
can-1768	241	7	120–128	120–128	NUM
can-1768	241	8	.	.	PUNCT
can-1768	242	1	23	23	NUM
can-1768	242	2	.	.	PUNCT
can-1768	242	3	nair	nair	PROPN
can-1768	242	4	kgs	kgs	PROPN
can-1768	242	5	,	,	PUNCT
can-1768	242	6	velmurugan	velmurugan	ADJ
can-1768	242	7	r	r	NOUN
can-1768	242	8	,	,	PUNCT
can-1768	242	9	sukumaran	sukumaran	VERB
can-1768	242	10	sk	sk	NOUN
can-1768	242	11	.	.	PROPN
can-1768	242	12	formulation	formulation	NOUN
can-1768	242	13	and	and	CCONJ
can-1768	242	14	optimization	optimization	NOUN
can-1768	242	15	of	of	ADP
can-1768	242	16	ansamycin	ansamycin	PROPN
can-1768	242	17	-	-	PUNCT
can-1768	242	18	loaded	load	VERB
can-1768	242	19	polymeric	polymeric	ADJ
can-1768	242	20	nanoparticles	nanoparticle	NOUN
can-1768	242	21	using	use	VERB
can-1768	242	22	response	response	NOUN
can-1768	242	23	surface	surface	NOUN
can-1768	242	24	methodology	methodology	NOUN
can-1768	242	25	for	for	ADP
can-1768	242	26	bacterial	bacterial	ADJ
can-1768	242	27	meningitis	meningitis	NOUN
can-1768	242	28	.	.	PUNCT
can-1768	243	1	bionanoscience	bionanoscience	NOUN
can-1768	243	2	2020	2020	NUM
can-1768	243	3	;	;	PUNCT
can-1768	243	4	10(1	10(1	NUM
can-1768	243	5	):	):	PUNCT
can-1768	243	6	279–291	279–291	NUM
can-1768	243	7	.	.	PUNCT
can-1768	244	1	24	24	NUM
can-1768	244	2	.	.	PUNCT
can-1768	245	1	mehnert	mehnert	PROPN
can-1768	245	2	w	w	PROPN
can-1768	245	3	,	,	PUNCT
can-1768	245	4	mäder	mäder	PROPN
can-1768	245	5	k.	k.	PROPN
can-1768	245	6	solid	solid	PROPN
can-1768	245	7	lipid	lipid	ADJ
can-1768	245	8	nanoparticles	nanoparticle	NOUN
can-1768	245	9	:	:	PUNCT
can-1768	245	10	production	production	NOUN
can-1768	245	11	,	,	PUNCT
can-1768	245	12	characterization	characterization	NOUN
can-1768	245	13	and	and	CCONJ
can-1768	245	14	applications	application	NOUN
can-1768	245	15	.	.	PUNCT
can-1768	246	1	advanced	advanced	ADJ
can-1768	246	2	drug	drug	NOUN
can-1768	246	3	delivery	delivery	NOUN
can-1768	246	4	reviews	review	NOUN
can-1768	246	5	2012	2012	NUM
can-1768	246	6	;	;	PUNCT
can-1768	246	7	64	64	NUM
can-1768	246	8	:	:	PUNCT
can-1768	246	9	83–101	83–101	NUM
can-1768	246	10	.	.	PUNCT
can-1768	247	1	25	25	NUM
can-1768	247	2	.	.	PUNCT
can-1768	248	1	tadros	tadros	PROPN
can-1768	248	2	tf	tf	PROPN
can-1768	248	3	,	,	PUNCT
can-1768	248	4	vincent	vincent	PROPN
can-1768	248	5	b.	b.	PROPN
can-1768	248	6	influence	influence	NOUN
can-1768	248	7	of	of	ADP
can-1768	248	8	temperature	temperature	NOUN
can-1768	248	9	and	and	CCONJ
can-1768	248	10	electrolytes	electrolyte	NOUN
can-1768	248	11	on	on	ADP
can-1768	248	12	the	the	DET
can-1768	248	13	adsorption	adsorption	NOUN
can-1768	248	14	of	of	ADP
can-1768	248	15	poly	poly	ADJ
can-1768	248	16	(	(	PUNCT
can-1768	248	17	ethylene	ethylene	NOUN
can-1768	248	18	oxide)-poly	oxide)-poly	PROPN
can-1768	248	19	(	(	PUNCT
can-1768	248	20	propylene	propylene	NOUN
can-1768	248	21	oxide	oxide	NOUN
can-1768	248	22	)	)	PUNCT
can-1768	248	23	block	block	NOUN
can-1768	248	24	copolymer	copolymer	NOUN
can-1768	248	25	on	on	ADP
can-1768	248	26	polystyrene	polystyrene	NOUN
can-1768	248	27	latex	latex	NOUN
can-1768	248	28	and	and	CCONJ
can-1768	248	29	on	on	ADP
can-1768	248	30	the	the	DET
can-1768	248	31	stability	stability	NOUN
can-1768	248	32	of	of	ADP
can-1768	248	33	the	the	DET
can-1768	248	34	polymer	polymer	NOUN
can-1768	248	35	-	-	PUNCT
can-1768	248	36	coated	coat	VERB
can-1768	248	37	particles	particle	NOUN
can-1768	248	38	.	.	PUNCT
can-1768	249	1	the	the	DET
can-1768	249	2	journal	journal	NOUN
can-1768	249	3	of	of	ADP
can-1768	249	4	physical	physical	ADJ
can-1768	249	5	chemistry	chemistry	NOUN
can-1768	249	6	1980	1980	NUM
can-1768	249	7	;	;	PUNCT
can-1768	249	8	84(12	84(12	NUM
can-1768	249	9	):	):	PUNCT
can-1768	249	10	1575	1575	NUM
can-1768	249	11	-	-	SYM
can-1768	249	12	1580	1580	NUM
can-1768	249	13	.	.	PUNCT
can-1768	250	1	26	26	NUM
can-1768	250	2	.	.	PUNCT
can-1768	251	1	krishnamachari	krishnamachari	PROPN
can-1768	251	2	y	y	PROPN
can-1768	251	3	,	,	PUNCT
can-1768	251	4	madan	madan	PROPN
can-1768	251	5	p	p	X
can-1768	251	6	,	,	PUNCT
can-1768	251	7	lin	lin	PROPN
can-1768	251	8	s.	s.	PROPN
can-1768	251	9	development	development	PROPN
can-1768	251	10	of	of	ADP
can-1768	251	11	phand	phand	PROPN
can-1768	251	12	time	time	NOUN
can-1768	251	13	-	-	PUNCT
can-1768	251	14	dependent	dependent	ADJ
can-1768	251	15	oral	oral	ADJ
can-1768	251	16	microparticles	microparticle	NOUN
can-1768	251	17	to	to	PART
can-1768	251	18	optimize	optimize	VERB
can-1768	251	19	budesonide	budesonide	NOUN
can-1768	251	20	delivery	delivery	NOUN
can-1768	251	21	to	to	ADP
can-1768	251	22	ileum	ileum	NOUN
can-1768	251	23	and	and	CCONJ
can-1768	251	24	colon	colon	NOUN
can-1768	251	25	.	.	PUNCT
can-1768	252	1	international	international	ADJ
can-1768	252	2	journal	journal	PROPN
can-1768	252	3	of	of	ADP
can-1768	252	4	pharmaceutics	pharmaceutic	NOUN
can-1768	252	5	2007	2007	NUM
can-1768	252	6	;	;	PUNCT
can-1768	252	7	338(1–2	338(1–2	NUM
can-1768	252	8	):	):	PUNCT
can-1768	252	9	238–247	238–247	NUM
can-1768	252	10	.	.	PUNCT