id	author	title	date	pages	extension	mime	words	sentence	flesch	summary	cache	txt
cet-12770		cet-12770		6	.pdf	application/pdf	3300	185	61	Taking this case as an example, the simulation results of its drug concentration and drug effect are shown in the Figure 2, and it can provide effective drug effect within a certain period of time in each cycle. In this model, tolerance is attributed to the accumulation of drug metabolites as drug antagonists, which leads to the decrease of drug effects over time.	cache/cet-12770.pdf	txt/cet-12770.txt