id	sid	tid	token	lemma	pos
cet-12770	1	1	pres22_0231.docx	pres22_0231.docx	PROPN
cet-12770	1	2	doi	doi	NOUN
cet-12770	1	3	:	:	PUNCT
cet-12770	1	4	10.3303	10.3303	NUM
cet-12770	1	5	/	/	SYM
cet-12770	1	6	cet2294213	cet2294213	NOUN
cet-12770	1	7	paper	paper	NOUN
cet-12770	1	8	received	receive	VERB
cet-12770	1	9	:	:	PUNCT
cet-12770	1	10	16	16	NUM
cet-12770	1	11	april	april	PROPN
cet-12770	1	12	2022	2022	NUM
cet-12770	1	13	;	;	PUNCT
cet-12770	1	14	revised	revise	VERB
cet-12770	1	15	:	:	PUNCT
cet-12770	1	16	09	09	NUM
cet-12770	1	17	may	may	PROPN
cet-12770	1	18	2022	2022	NUM
cet-12770	1	19	;	;	PUNCT
cet-12770	1	20	accepted	accept	VERB
cet-12770	1	21	:	:	PUNCT
cet-12770	1	22	14	14	NUM
cet-12770	1	23	may	may	AUX
cet-12770	1	24	2022	2022	NUM
cet-12770	1	25	please	please	INTJ
cet-12770	1	26	cite	cite	VERB
cet-12770	1	27	this	this	DET
cet-12770	1	28	article	article	NOUN
cet-12770	1	29	as	as	ADP
cet-12770	1	30	:	:	PUNCT
cet-12770	1	31	ai	ai	INTJ
cet-12770	1	32	j.	j.	PROPN
cet-12770	1	33	,	,	PUNCT
cet-12770	1	34	dai	dai	PROPN
cet-12770	1	35	j.	j.	PROPN
cet-12770	1	36	,	,	PUNCT
cet-12770	1	37	zhai	zhai	PROPN
cet-12770	1	38	c.	c.	PROPN
cet-12770	1	39	,	,	PUNCT
cet-12770	1	40	sun	sun	PROPN
cet-12770	1	41	w.	w.	PROPN
cet-12770	1	42	,	,	PUNCT
cet-12770	1	43	2022	2022	NUM
cet-12770	1	44	,	,	PUNCT
cet-12770	1	45	pulse	pulse	NOUN
cet-12770	1	46	drug	drug	NOUN
cet-12770	1	47	delivery	delivery	NOUN
cet-12770	1	48	strategy	strategy	NOUN
cet-12770	1	49	based	base	VERB
cet-12770	1	50	on	on	ADP
cet-12770	1	51	pharmacokinetic	pharmacokinetic	NOUN
cet-12770	1	52	-	-	PUNCT
cet-12770	1	53	pharmacodynamic	pharmacodynamic	ADJ
cet-12770	1	54	(	(	PUNCT
cet-12770	1	55	pkpd	pkpd	PROPN
cet-12770	1	56	)	)	PUNCT
cet-12770	1	57	model	model	NOUN
cet-12770	1	58	of	of	ADP
cet-12770	1	59	tolerance	tolerance	NOUN
cet-12770	1	60	,	,	PUNCT
cet-12770	1	61	chemical	chemical	NOUN
cet-12770	1	62	engineering	engineering	NOUN
cet-12770	1	63	transactions	transaction	NOUN
cet-12770	1	64	,	,	PUNCT
cet-12770	1	65	94	94	NUM
cet-12770	1	66	,	,	PUNCT
cet-12770	1	67	1279	1279	NUM
cet-12770	1	68	-	-	SYM
cet-12770	1	69	1284	1284	NUM
cet-12770	1	70	doi:10.3303	doi:10.3303	NOUN
cet-12770	1	71	/	/	SYM
cet-12770	1	72	cet2294213	cet2294213	NOUN
cet-12770	1	73	chemical	chemical	PROPN
cet-12770	1	74	engineering	engineering	NOUN
cet-12770	1	75	transactions	transaction	NOUN
cet-12770	1	76	vol	vol	NOUN
cet-12770	1	77	.	.	PROPN
cet-12770	1	78	94	94	NUM
cet-12770	1	79	,	,	PUNCT
cet-12770	1	80	2022	2022	NUM
cet-12770	1	81	a	a	DET
cet-12770	1	82	publication	publication	NOUN
cet-12770	1	83	of	of	ADP
cet-12770	1	84	the	the	DET
cet-12770	1	85	italian	italian	ADJ
cet-12770	1	86	association	association	NOUN
cet-12770	1	87	of	of	ADP
cet-12770	1	88	chemical	chemical	PROPN
cet-12770	1	89	engineering	engineering	NOUN
cet-12770	1	90	online	online	ADV
cet-12770	1	91	at	at	ADP
cet-12770	1	92	www.cetjournal.it	www.cetjournal.it	PROPN
cet-12770	1	93	guest	guest	NOUN
cet-12770	1	94	editors	editor	NOUN
cet-12770	1	95	:	:	PUNCT
cet-12770	1	96	petar	petar	PROPN
cet-12770	1	97	s.	s.	PROPN
cet-12770	1	98	varbanov	varbanov	PROPN
cet-12770	1	99	,	,	PUNCT
cet-12770	1	100	yee	yee	PROPN
cet-12770	1	101	van	van	PROPN
cet-12770	1	102	fan	fan	PROPN
cet-12770	1	103	,	,	PUNCT
cet-12770	1	104	jiří	jiří	NOUN
cet-12770	1	105	j.	j.	PROPN
cet-12770	1	106	klemeš	klemeš	PROPN
cet-12770	1	107	,	,	PUNCT
cet-12770	1	108	sandro	sandro	PROPN
cet-12770	1	109	nižetić	nižetić	PROPN
cet-12770	1	110	copyright	copyright	NOUN
cet-12770	1	111	©	©	PROPN
cet-12770	1	112	2022	2022	NUM
cet-12770	1	113	,	,	PUNCT
cet-12770	1	114	aidic	aidic	ADJ
cet-12770	1	115	servizi	servizi	PROPN
cet-12770	1	116	s.r.l	s.r.l	PROPN
cet-12770	1	117	.	.	PUNCT
cet-12770	2	1	isbn	isbn	ADJ
cet-12770	2	2	978	978	NUM
cet-12770	2	3	-	-	SYM
cet-12770	2	4	88	88	NUM
cet-12770	2	5	-	-	PUNCT
cet-12770	2	6	95608	95608	NUM
cet-12770	2	7	-	-	PUNCT
cet-12770	2	8	93	93	NUM
cet-12770	2	9	-	-	SYM
cet-12770	2	10	8	8	NUM
cet-12770	2	11	;	;	PUNCT
cet-12770	2	12	issn	issn	PROPN
cet-12770	2	13	2283	2283	NUM
cet-12770	2	14	-	-	SYM
cet-12770	2	15	9216	9216	NUM
cet-12770	2	16	pulse	pulse	NOUN
cet-12770	2	17	drug	drug	NOUN
cet-12770	2	18	delivery	delivery	NOUN
cet-12770	2	19	strategy	strategy	NOUN
cet-12770	2	20	based	base	VERB
cet-12770	2	21	on	on	ADP
cet-12770	2	22	pharmacokineticpharmacodynamic	pharmacokineticpharmacodynamic	ADJ
cet-12770	2	23	(	(	PUNCT
cet-12770	2	24	pk	pk	NOUN
cet-12770	2	25	-	-	PUNCT
cet-12770	2	26	pd	pd	NOUN
cet-12770	2	27	)	)	PUNCT
cet-12770	2	28	model	model	NOUN
cet-12770	2	29	of	of	ADP
cet-12770	2	30	tolerance	tolerance	NOUN
cet-12770	2	31	jiali	jiali	ADJ
cet-12770	2	32	aia	aia	PROPN
cet-12770	2	33	,	,	PUNCT
cet-12770	2	34	jindong	jindong	PROPN
cet-12770	2	35	daia	daia	PROPN
cet-12770	2	36	,	,	PUNCT
cet-12770	2	37	chi	chi	PROPN
cet-12770	2	38	zhaib	zhaib	PROPN
cet-12770	2	39	,	,	PUNCT
cet-12770	2	40	*	*	PUNCT
cet-12770	2	41	,	,	PUNCT
cet-12770	2	42	wei	wei	PROPN
cet-12770	2	43	suna	suna	PROPN
cet-12770	2	44	,	,	PUNCT
cet-12770	2	45	*	*	PUNCT
cet-12770	2	46	abeijing	abeijing	PROPN
cet-12770	2	47	university	university	PROPN
cet-12770	2	48	of	of	ADP
cet-12770	2	49	chemical	chemical	PROPN
cet-12770	2	50	technology	technology	PROPN
cet-12770	2	51	,	,	PUNCT
cet-12770	2	52	beijing	beijing	PROPN
cet-12770	2	53	,	,	PUNCT
cet-12770	2	54	china	china	PROPN
cet-12770	2	55	bkunming	bkunming	PROPN
cet-12770	2	56	university	university	PROPN
cet-12770	2	57	of	of	ADP
cet-12770	2	58	science	science	NOUN
cet-12770	2	59	and	and	CCONJ
cet-12770	2	60	technology	technology	NOUN
cet-12770	2	61	,	,	PUNCT
cet-12770	2	62	kunming	kunming	PROPN
cet-12770	2	63	,	,	PUNCT
cet-12770	2	64	china	china	PROPN
cet-12770	2	65	zhaichi@kmust.edu.cn	zhaichi@kmust.edu.cn	PROPN
cet-12770	2	66	and	and	CCONJ
cet-12770	2	67	sunwei@	sunwei@	NOUN
cet-12770	2	68	mail.buct.edu.cn	mail.buct.edu.cn	PROPN
cet-12770	2	69	in	in	ADP
cet-12770	2	70	clinical	clinical	ADJ
cet-12770	2	71	practice	practice	NOUN
cet-12770	2	72	,	,	PUNCT
cet-12770	2	73	the	the	DET
cet-12770	2	74	curative	curative	ADJ
cet-12770	2	75	effect	effect	NOUN
cet-12770	2	76	of	of	ADP
cet-12770	2	77	drugs	drug	NOUN
cet-12770	2	78	will	will	AUX
cet-12770	2	79	decrease	decrease	VERB
cet-12770	2	80	due	due	ADP
cet-12770	2	81	to	to	ADP
cet-12770	2	82	the	the	DET
cet-12770	2	83	increase	increase	NOUN
cet-12770	2	84	of	of	ADP
cet-12770	2	85	drug	drug	NOUN
cet-12770	2	86	resistance	resistance	NOUN
cet-12770	2	87	,	,	PUNCT
cet-12770	2	88	especially	especially	ADV
cet-12770	2	89	in	in	ADP
cet-12770	2	90	stable	stable	ADJ
cet-12770	2	91	long	long	ADJ
cet-12770	2	92	-	-	PUNCT
cet-12770	2	93	term	term	NOUN
cet-12770	2	94	drug	drug	NOUN
cet-12770	2	95	delivery	delivery	NOUN
cet-12770	2	96	systems	system	NOUN
cet-12770	2	97	.	.	PUNCT
cet-12770	3	1	intermittent	intermittent	ADJ
cet-12770	3	2	drug	drug	NOUN
cet-12770	3	3	dosing	dosing	NOUN
cet-12770	3	4	is	be	AUX
cet-12770	3	5	an	an	DET
cet-12770	3	6	effective	effective	ADJ
cet-12770	3	7	method	method	NOUN
cet-12770	3	8	to	to	PART
cet-12770	3	9	reduce	reduce	VERB
cet-12770	3	10	drug	drug	NOUN
cet-12770	3	11	resistance	resistance	NOUN
cet-12770	3	12	and	and	CCONJ
cet-12770	3	13	achieve	achieve	VERB
cet-12770	3	14	a	a	DET
cet-12770	3	15	better	well	ADJ
cet-12770	3	16	effect	effect	NOUN
cet-12770	3	17	comparing	compare	VERB
cet-12770	3	18	with	with	ADP
cet-12770	3	19	consistent	consistent	ADJ
cet-12770	3	20	one	one	NUM
cet-12770	3	21	.	.	PUNCT
cet-12770	4	1	the	the	DET
cet-12770	4	2	relationship	relationship	NOUN
cet-12770	4	3	between	between	ADP
cet-12770	4	4	drug	drug	NOUN
cet-12770	4	5	concentration	concentration	NOUN
cet-12770	4	6	and	and	CCONJ
cet-12770	4	7	effect	effect	NOUN
cet-12770	4	8	can	can	AUX
cet-12770	4	9	be	be	AUX
cet-12770	4	10	described	describe	VERB
cet-12770	4	11	by	by	ADP
cet-12770	4	12	pharmacokinetics	pharmacokinetic	NOUN
cet-12770	4	13	-	-	PUNCT
cet-12770	4	14	pharmacodynamics	pharmacodynamic	NOUN
cet-12770	4	15	(	(	PUNCT
cet-12770	4	16	pk	pk	NOUN
cet-12770	4	17	-	-	PUNCT
cet-12770	4	18	pd	pd	NOUN
cet-12770	4	19	)	)	PUNCT
cet-12770	4	20	model	model	NOUN
cet-12770	4	21	,	,	PUNCT
cet-12770	4	22	and	and	CCONJ
cet-12770	4	23	a	a	DET
cet-12770	4	24	more	more	ADV
cet-12770	4	25	suitable	suitable	ADJ
cet-12770	4	26	drug	drug	NOUN
cet-12770	4	27	delivery	delivery	NOUN
cet-12770	4	28	strategy	strategy	NOUN
cet-12770	4	29	can	can	AUX
cet-12770	4	30	be	be	AUX
cet-12770	4	31	obtained	obtain	VERB
cet-12770	4	32	through	through	ADP
cet-12770	4	33	analysis	analysis	NOUN
cet-12770	4	34	.	.	PUNCT
cet-12770	5	1	in	in	ADP
cet-12770	5	2	this	this	DET
cet-12770	5	3	paper	paper	NOUN
cet-12770	5	4	,	,	PUNCT
cet-12770	5	5	a	a	DET
cet-12770	5	6	periodic	periodic	ADJ
cet-12770	5	7	dosing	dose	VERB
cet-12770	5	8	strategy	strategy	NOUN
cet-12770	5	9	is	be	AUX
cet-12770	5	10	proposed	propose	VERB
cet-12770	5	11	based	base	VERB
cet-12770	5	12	on	on	ADP
cet-12770	5	13	a	a	DET
cet-12770	5	14	simple	simple	ADJ
cet-12770	5	15	pk	pk	ADJ
cet-12770	5	16	-	-	PUNCT
cet-12770	5	17	pd	pd	NOUN
cet-12770	5	18	model	model	NOUN
cet-12770	5	19	of	of	ADP
cet-12770	5	20	tolerance	tolerance	NOUN
cet-12770	5	21	.	.	PUNCT
cet-12770	6	1	through	through	ADP
cet-12770	6	2	the	the	DET
cet-12770	6	3	analysis	analysis	NOUN
cet-12770	6	4	of	of	ADP
cet-12770	6	5	this	this	DET
cet-12770	6	6	model	model	NOUN
cet-12770	6	7	,	,	PUNCT
cet-12770	6	8	a	a	DET
cet-12770	6	9	pulse	pulse	NOUN
cet-12770	6	10	drug	drug	NOUN
cet-12770	6	11	delivery	delivery	NOUN
cet-12770	6	12	strategy	strategy	NOUN
cet-12770	6	13	is	be	AUX
cet-12770	6	14	established	establish	VERB
cet-12770	6	15	,	,	PUNCT
cet-12770	6	16	which	which	PRON
cet-12770	6	17	is	be	AUX
cet-12770	6	18	corresponding	correspond	VERB
cet-12770	6	19	to	to	ADP
cet-12770	6	20	the	the	DET
cet-12770	6	21	rhythm	rhythm	NOUN
cet-12770	6	22	of	of	ADP
cet-12770	6	23	human	human	ADJ
cet-12770	6	24	body	body	NOUN
cet-12770	6	25	and	and	CCONJ
cet-12770	6	26	easy	easy	ADJ
cet-12770	6	27	for	for	ADP
cet-12770	6	28	drug	drug	NOUN
cet-12770	6	29	design	design	NOUN
cet-12770	6	30	.	.	PUNCT
cet-12770	7	1	by	by	ADP
cet-12770	7	2	discretizing	discretize	VERB
cet-12770	7	3	the	the	DET
cet-12770	7	4	differential	differential	ADJ
cet-12770	7	5	equations	equation	NOUN
cet-12770	7	6	into	into	ADP
cet-12770	7	7	algebraic	algebraic	ADJ
cet-12770	7	8	equations	equation	NOUN
cet-12770	7	9	based	base	VERB
cet-12770	7	10	on	on	ADP
cet-12770	7	11	the	the	DET
cet-12770	7	12	collocation	collocation	NOUN
cet-12770	7	13	method	method	NOUN
cet-12770	7	14	,	,	PUNCT
cet-12770	7	15	the	the	DET
cet-12770	7	16	drug	drug	NOUN
cet-12770	7	17	delivery	delivery	NOUN
cet-12770	7	18	strategy	strategy	NOUN
cet-12770	7	19	is	be	AUX
cet-12770	7	20	optimized	optimize	VERB
cet-12770	7	21	.	.	PUNCT
cet-12770	8	1	then	then	ADV
cet-12770	8	2	,	,	PUNCT
cet-12770	8	3	the	the	DET
cet-12770	8	4	optimized	optimize	VERB
cet-12770	8	5	drug	drug	NOUN
cet-12770	8	6	delivery	delivery	NOUN
cet-12770	8	7	system	system	NOUN
cet-12770	8	8	is	be	AUX
cet-12770	8	9	simulated	simulate	VERB
cet-12770	8	10	by	by	ADP
cet-12770	8	11	the	the	DET
cet-12770	8	12	fourth	fourth	ADJ
cet-12770	8	13	-	-	PUNCT
cet-12770	8	14	order	order	NOUN
cet-12770	8	15	runge	runge	NOUN
cet-12770	8	16	-	-	PUNCT
cet-12770	8	17	kutta	kutta	NOUN
cet-12770	8	18	method	method	NOUN
cet-12770	8	19	.	.	PUNCT
cet-12770	9	1	based	base	VERB
cet-12770	9	2	on	on	ADP
cet-12770	9	3	this	this	DET
cet-12770	9	4	method	method	NOUN
cet-12770	9	5	,	,	PUNCT
cet-12770	9	6	a	a	DET
cet-12770	9	7	reference	reference	NOUN
cet-12770	9	8	for	for	ADP
cet-12770	9	9	designing	design	VERB
cet-12770	9	10	a	a	DET
cet-12770	9	11	drug	drug	NOUN
cet-12770	9	12	delivery	delivery	NOUN
cet-12770	9	13	system	system	NOUN
cet-12770	9	14	can	can	AUX
cet-12770	9	15	be	be	AUX
cet-12770	9	16	provided	provide	VERB
cet-12770	9	17	to	to	PART
cet-12770	9	18	reduce	reduce	VERB
cet-12770	9	19	unnecessary	unnecessary	ADJ
cet-12770	9	20	dosage	dosage	NOUN
cet-12770	9	21	and	and	CCONJ
cet-12770	9	22	improve	improve	VERB
cet-12770	9	23	drug	drug	NOUN
cet-12770	9	24	efficacy	efficacy	NOUN
cet-12770	9	25	.	.	PUNCT
cet-12770	10	1	1	1	X
cet-12770	10	2	.	.	X
cet-12770	10	3	introduction	introduction	NOUN
cet-12770	10	4	it	it	PRON
cet-12770	10	5	is	be	AUX
cet-12770	10	6	critical	critical	ADJ
cet-12770	10	7	for	for	SCONJ
cet-12770	10	8	clinic	clinic	ADJ
cet-12770	10	9	treatment	treatment	NOUN
cet-12770	10	10	to	to	PART
cet-12770	10	11	deliver	deliver	VERB
cet-12770	10	12	drugs	drug	NOUN
cet-12770	10	13	in	in	ADP
cet-12770	10	14	a	a	DET
cet-12770	10	15	way	way	NOUN
cet-12770	10	16	that	that	PRON
cet-12770	10	17	rationally	rationally	ADV
cet-12770	10	18	matches	match	VERB
cet-12770	10	19	the	the	DET
cet-12770	10	20	pharmacokineticpharmacodynamic	pharmacokineticpharmacodynamic	ADJ
cet-12770	10	21	(	(	PUNCT
cet-12770	10	22	pk	pk	NOUN
cet-12770	10	23	-	-	PUNCT
cet-12770	10	24	pd	pd	NOUN
cet-12770	10	25	)	)	PUNCT
cet-12770	10	26	model	model	NOUN
cet-12770	10	27	.	.	PUNCT
cet-12770	11	1	for	for	ADP
cet-12770	11	2	many	many	ADJ
cet-12770	11	3	drugs	drug	NOUN
cet-12770	11	4	,	,	PUNCT
cet-12770	11	5	their	their	PRON
cet-12770	11	6	effect	effect	NOUN
cet-12770	11	7	depends	depend	VERB
cet-12770	11	8	not	not	PART
cet-12770	11	9	only	only	ADV
cet-12770	11	10	on	on	ADP
cet-12770	11	11	current	current	ADJ
cet-12770	11	12	concentration	concentration	NOUN
cet-12770	11	13	but	but	CCONJ
cet-12770	11	14	also	also	ADV
cet-12770	11	15	on	on	ADP
cet-12770	11	16	exposure	exposure	NOUN
cet-12770	11	17	history	history	NOUN
cet-12770	11	18	.	.	PUNCT
cet-12770	12	1	when	when	SCONJ
cet-12770	12	2	the	the	DET
cet-12770	12	3	effect	effect	NOUN
cet-12770	12	4	of	of	ADP
cet-12770	12	5	the	the	DET
cet-12770	12	6	drug	drug	NOUN
cet-12770	12	7	is	be	AUX
cet-12770	12	8	weakened	weaken	VERB
cet-12770	12	9	due	due	ADJ
cet-12770	12	10	to	to	ADP
cet-12770	12	11	continuous	continuous	ADJ
cet-12770	12	12	exposure	exposure	NOUN
cet-12770	12	13	,	,	PUNCT
cet-12770	12	14	patients	patient	NOUN
cet-12770	12	15	are	be	AUX
cet-12770	12	16	considered	consider	VERB
cet-12770	12	17	to	to	PART
cet-12770	12	18	have	have	AUX
cet-12770	12	19	developed	develop	VERB
cet-12770	12	20	tolerance	tolerance	NOUN
cet-12770	12	21	to	to	ADP
cet-12770	12	22	the	the	DET
cet-12770	12	23	drug	drug	NOUN
cet-12770	12	24	.	.	PUNCT
cet-12770	13	1	pochett	pochett	PROPN
cet-12770	13	2	et.al	et.al	PROPN
cet-12770	13	3	.	.	PUNCT
cet-12770	14	1	(	(	PUNCT
cet-12770	14	2	1988	1988	NUM
cet-12770	14	3	)	)	PUNCT
cet-12770	14	4	proposed	propose	VERB
cet-12770	14	5	a	a	DET
cet-12770	14	6	pk	pk	PROPN
cet-12770	14	7	-	-	PUNCT
cet-12770	14	8	pd	pd	NOUN
cet-12770	14	9	model	model	NOUN
cet-12770	14	10	that	that	PRON
cet-12770	14	11	can	can	AUX
cet-12770	14	12	be	be	AUX
cet-12770	14	13	utilized	utilize	VERB
cet-12770	14	14	to	to	PART
cet-12770	14	15	describe	describe	VERB
cet-12770	14	16	the	the	DET
cet-12770	14	17	development	development	NOUN
cet-12770	14	18	of	of	ADP
cet-12770	14	19	tolerance	tolerance	NOUN
cet-12770	14	20	.	.	PUNCT
cet-12770	15	1	in	in	ADP
cet-12770	15	2	this	this	DET
cet-12770	15	3	model	model	NOUN
cet-12770	15	4	,	,	PUNCT
cet-12770	15	5	tolerance	tolerance	NOUN
cet-12770	15	6	is	be	AUX
cet-12770	15	7	attributed	attribute	VERB
cet-12770	15	8	to	to	ADP
cet-12770	15	9	the	the	DET
cet-12770	15	10	accumulation	accumulation	NOUN
cet-12770	15	11	of	of	ADP
cet-12770	15	12	drug	drug	NOUN
cet-12770	15	13	metabolites	metabolite	NOUN
cet-12770	15	14	as	as	ADP
cet-12770	15	15	drug	drug	NOUN
cet-12770	15	16	antagonists	antagonist	NOUN
cet-12770	15	17	,	,	PUNCT
cet-12770	15	18	which	which	PRON
cet-12770	15	19	leads	lead	VERB
cet-12770	15	20	to	to	ADP
cet-12770	15	21	the	the	DET
cet-12770	15	22	decrease	decrease	NOUN
cet-12770	15	23	of	of	ADP
cet-12770	15	24	drug	drug	NOUN
cet-12770	15	25	effects	effect	NOUN
cet-12770	15	26	over	over	ADP
cet-12770	15	27	time	time	NOUN
cet-12770	15	28	.	.	PUNCT
cet-12770	16	1	on	on	ADP
cet-12770	16	2	this	this	DET
cet-12770	16	3	basis	basis	NOUN
cet-12770	16	4	,	,	PUNCT
cet-12770	16	5	varigonda	varigonda	NOUN
cet-12770	16	6	et.al	et.al	PROPN
cet-12770	16	7	.	.	PUNCT
cet-12770	17	1	(	(	PUNCT
cet-12770	17	2	2004	2004	NUM
cet-12770	17	3	)	)	PUNCT
cet-12770	17	4	proposed	propose	VERB
cet-12770	17	5	a	a	DET
cet-12770	17	6	dimensionless	dimensionless	NOUN
cet-12770	17	7	model	model	NOUN
cet-12770	17	8	in	in	ADP
cet-12770	17	9	which	which	PRON
cet-12770	17	10	all	all	DET
cet-12770	17	11	variables	variable	NOUN
cet-12770	17	12	and	and	CCONJ
cet-12770	17	13	drug	drug	NOUN
cet-12770	17	14	inputs	input	NOUN
cet-12770	17	15	are	be	AUX
cet-12770	17	16	non	non	ADJ
cet-12770	17	17	-	-	ADJ
cet-12770	17	18	negative	negative	ADJ
cet-12770	17	19	.	.	PUNCT
cet-12770	18	1	the	the	DET
cet-12770	18	2	(	(	PUNCT
cet-12770	18	3	dimensionless	dimensionless	NOUN
cet-12770	18	4	)	)	PUNCT
cet-12770	18	5	drug	drug	NOUN
cet-12770	18	6	concentration	concentration	NOUN
cet-12770	18	7	and	and	CCONJ
cet-12770	18	8	metabolite	metabolite	NOUN
cet-12770	18	9	(	(	PUNCT
cet-12770	18	10	antagonist	antagonist	NOUN
cet-12770	18	11	)	)	PUNCT
cet-12770	18	12	concentrations	concentration	NOUN
cet-12770	18	13	are	be	AUX
cet-12770	18	14	denoted	denote	VERB
cet-12770	18	15	as	as	ADP
cet-12770	18	16	𝑐𝑐(0	𝑐𝑐(0	PROPN
cet-12770	18	17	≤	≤	NUM
cet-12770	18	18	c	c	NOUN
cet-12770	18	19	≤	≤	NUM
cet-12770	18	20	10	10	NUM
cet-12770	18	21	)	)	PUNCT
cet-12770	18	22	and	and	CCONJ
cet-12770	18	23	𝑎𝑎(0	𝑎𝑎(0	PROPN
cet-12770	18	24	≤	≤	PROPN
cet-12770	18	25	a	a	DET
cet-12770	18	26	≤	≤	NUM
cet-12770	18	27	10	10	NUM
cet-12770	18	28	)	)	PUNCT
cet-12770	18	29	.	.	PUNCT
cet-12770	19	1	the	the	DET
cet-12770	19	2	pharmacokinetic	pharmacokinetic	ADJ
cet-12770	19	3	model	model	NOUN
cet-12770	19	4	is	be	AUX
cet-12770	19	5	shown	show	VERB
cet-12770	19	6	in	in	ADP
cet-12770	19	7	eq(1	eq(1	NOUN
cet-12770	19	8	)	)	PUNCT
cet-12770	19	9	.	.	PUNCT
cet-12770	20	1	�	�	PROPN
cet-12770	20	2	𝑑𝑑𝑑𝑑	𝑑𝑑𝑑𝑑	PROPN
cet-12770	20	3	𝑑𝑑𝑑𝑑	𝑑𝑑𝑑𝑑	NOUN
cet-12770	21	1	=	=	PUNCT
cet-12770	22	1	𝑢𝑢	𝑢𝑢	INTJ
cet-12770	22	2	−	−	NOUN
cet-12770	23	1	𝑐𝑐	𝑐𝑐	PROPN
cet-12770	23	2	𝑑𝑑𝑑𝑑	𝑑𝑑𝑑𝑑	NOUN
cet-12770	23	3	𝑑𝑑𝑑𝑑	𝑑𝑑𝑑𝑑	NOUN
cet-12770	24	1	=	=	PUNCT
cet-12770	25	1	𝑘𝑘(𝑐𝑐	𝑘𝑘(𝑐𝑐	NOUN
cet-12770	25	2	−	−	NOUN
cet-12770	25	3	𝑎𝑎	𝑎𝑎	NOUN
cet-12770	25	4	)	)	PUNCT
cet-12770	25	5	(	(	PUNCT
cet-12770	25	6	1	1	X
cet-12770	25	7	)	)	PUNCT
cet-12770	25	8	where	where	SCONJ
cet-12770	25	9	𝑢𝑢(0	𝑢𝑢(0	PROPN
cet-12770	25	10	≤	≤	X
cet-12770	25	11	𝑢𝑢	𝑢𝑢	INTJ
cet-12770	25	12	≤	≤	NUM
cet-12770	25	13	10	10	NUM
cet-12770	25	14	)	)	PUNCT
cet-12770	25	15	represents	represent	VERB
cet-12770	25	16	the	the	DET
cet-12770	25	17	dosing	dose	VERB
cet-12770	25	18	rate	rate	NOUN
cet-12770	25	19	,	,	PUNCT
cet-12770	25	20	𝑘𝑘	𝑘𝑘	PROPN
cet-12770	25	21	is	be	AUX
cet-12770	25	22	a	a	DET
cet-12770	25	23	constant	constant	ADJ
cet-12770	25	24	(	(	PUNCT
cet-12770	25	25	usually	usually	ADV
cet-12770	25	26	𝑘𝑘	𝑘𝑘	X
cet-12770	25	27	=	=	NOUN
cet-12770	25	28	0.1	0.1	NUM
cet-12770	25	29	)	)	PUNCT
cet-12770	25	30	that	that	PRON
cet-12770	25	31	represents	represent	VERB
cet-12770	25	32	antagonist	antagonist	NOUN
cet-12770	25	33	elimination	elimination	NOUN
cet-12770	25	34	rate	rate	NOUN
cet-12770	25	35	.	.	PUNCT
cet-12770	26	1	the	the	DET
cet-12770	26	2	drug	drug	NOUN
cet-12770	26	3	effect	effect	NOUN
cet-12770	26	4	is	be	AUX
cet-12770	26	5	represented	represent	VERB
cet-12770	26	6	by	by	ADP
cet-12770	26	7	𝐸𝐸	𝐸𝐸	PROPN
cet-12770	26	8	and	and	CCONJ
cet-12770	26	9	is	be	AUX
cet-12770	26	10	given	give	VERB
cet-12770	26	11	by	by	ADP
cet-12770	26	12	eq(2	eq(2	PROPN
cet-12770	26	13	)	)	PUNCT
cet-12770	26	14	.	.	PUNCT
cet-12770	27	1	𝐸𝐸	𝐸𝐸	PROPN
cet-12770	27	2	=	=	SYM
cet-12770	27	3	𝑑𝑑	𝑑𝑑	X
cet-12770	27	4	(	(	PUNCT
cet-12770	27	5	1+𝑑𝑑)(1+𝑑𝑑	1+𝑑𝑑)(1+𝑑𝑑	NUM
cet-12770	27	6	𝑑𝑑∗⁄	𝑑𝑑∗⁄	NOUN
cet-12770	27	7	)	)	PUNCT
cet-12770	27	8	(	(	PUNCT
cet-12770	28	1	2	2	X
cet-12770	28	2	)	)	PUNCT
cet-12770	28	3	there	there	PRON
cet-12770	28	4	is	be	VERB
cet-12770	28	5	an	an	DET
cet-12770	28	6	optimal	optimal	ADJ
cet-12770	28	7	stable	stable	ADJ
cet-12770	28	8	solution	solution	NOUN
cet-12770	28	9	which	which	PRON
cet-12770	28	10	is	be	AUX
cet-12770	28	11	given	give	VERB
cet-12770	28	12	as	as	ADP
cet-12770	28	13	𝑢𝑢	𝑢𝑢	PROPN
cet-12770	28	14	=	=	SYM
cet-12770	28	15	𝑐𝑐	𝑐𝑐	NOUN
cet-12770	28	16	=	=	NOUN
cet-12770	28	17	𝑎𝑎	𝑎𝑎	NOUN
cet-12770	28	18	=	=	SYM
cet-12770	28	19	𝑎𝑎∗	𝑎𝑎∗	NOUN
cet-12770	28	20	=	=	NOUN
cet-12770	28	21	1	1	X
cet-12770	28	22	.	.	PUNCT
cet-12770	29	1	the	the	DET
cet-12770	29	2	optimal	optimal	ADJ
cet-12770	29	3	drug	drug	NOUN
cet-12770	29	4	effect	effect	NOUN
cet-12770	29	5	is	be	AUX
cet-12770	29	6	given	give	VERB
cet-12770	29	7	as	as	ADP
cet-12770	29	8	𝐸𝐸	𝐸𝐸	PROPN
cet-12770	29	9	=	=	NUM
cet-12770	29	10	0.25	0.25	NUM
cet-12770	29	11	,	,	PUNCT
cet-12770	29	12	as	as	SCONJ
cet-12770	29	13	shown	show	VERB
cet-12770	29	14	in	in	ADP
cet-12770	29	15	figure	figure	NOUN
cet-12770	29	16	1	1	NUM
cet-12770	29	17	.	.	PUNCT
cet-12770	30	1	however	however	ADV
cet-12770	30	2	,	,	PUNCT
cet-12770	30	3	according	accord	VERB
cet-12770	30	4	to	to	ADP
cet-12770	30	5	pharmacodynamic	pharmacodynamic	ADJ
cet-12770	30	6	,	,	PUNCT
cet-12770	30	7	the	the	DET
cet-12770	30	8	drug	drug	NOUN
cet-12770	30	9	's	's	PART
cet-12770	30	10	effective	effective	ADJ
cet-12770	30	11	interval	interval	NOUN
cet-12770	30	12	is	be	AUX
cet-12770	30	13	0.3	0.3	NUM
cet-12770	30	14	<	<	X
cet-12770	30	15	𝐸𝐸	𝐸𝐸	PROPN
cet-12770	30	16	<	<	X
cet-12770	30	17	0.6	0.6	NUM
cet-12770	30	18	in	in	ADP
cet-12770	30	19	this	this	DET
cet-12770	30	20	model	model	NOUN
cet-12770	30	21	.	.	PUNCT
cet-12770	31	1	stable	stable	ADJ
cet-12770	31	2	input	input	NOUN
cet-12770	31	3	can	can	AUX
cet-12770	31	4	not	not	PART
cet-12770	31	5	meet	meet	VERB
cet-12770	31	6	the	the	DET
cet-12770	31	7	therapeutic	therapeutic	ADJ
cet-12770	31	8	effect	effect	NOUN
cet-12770	31	9	for	for	ADP
cet-12770	31	10	a	a	DET
cet-12770	31	11	long	long	ADJ
cet-12770	31	12	time	time	NOUN
cet-12770	31	13	,	,	PUNCT
cet-12770	31	14	which	which	PRON
cet-12770	31	15	is	be	AUX
cet-12770	31	16	unfavourable	unfavourable	ADJ
cet-12770	31	17	for	for	ADP
cet-12770	31	18	some	some	DET
cet-12770	31	19	chronic	chronic	ADJ
cet-12770	31	20	diseases	disease	NOUN
cet-12770	31	21	that	that	PRON
cet-12770	31	22	require	require	VERB
cet-12770	31	23	long	long	ADJ
cet-12770	31	24	-	-	PUNCT
cet-12770	31	25	term	term	NOUN
cet-12770	31	26	medication	medication	NOUN
cet-12770	31	27	.	.	PUNCT
cet-12770	32	1	a	a	DET
cet-12770	32	2	classic	classic	ADJ
cet-12770	32	3	example	example	NOUN
cet-12770	32	4	is	be	AUX
cet-12770	32	5	nitroglycerin	nitroglycerin	ADJ
cet-12770	32	6	patch	patch	NOUN
cet-12770	32	7	used	use	VERB
cet-12770	32	8	to	to	PART
cet-12770	32	9	prevent	prevent	VERB
cet-12770	32	10	angina	angina	PROPN
cet-12770	32	11	pectoris	pectoris	PROPN
cet-12770	32	12	.	.	PUNCT
cet-12770	33	1	these	these	DET
cet-12770	33	2	patches	patch	NOUN
cet-12770	33	3	should	should	AUX
cet-12770	33	4	be	be	AUX
cet-12770	33	5	worn	wear	VERB
cet-12770	33	6	24	24	NUM
cet-12770	33	7	h	h	NOUN
cet-12770	33	8	/	/	SYM
cet-12770	33	9	d	d	PROPN
cet-12770	33	10	and	and	CCONJ
cet-12770	33	11	replaced	replace	VERB
cet-12770	33	12	with	with	ADP
cet-12770	33	13	new	new	ADJ
cet-12770	33	14	patches	patch	NOUN
cet-12770	33	15	daily	daily	ADV
cet-12770	33	16	.	.	PUNCT
cet-12770	34	1	however	however	ADV
cet-12770	34	2	,	,	PUNCT
cet-12770	34	3	studies	study	NOUN
cet-12770	34	4	found	find	VERB
cet-12770	34	5	that	that	SCONJ
cet-12770	34	6	this	this	DET
cet-12770	34	7	protective	protective	ADJ
cet-12770	34	8	effect	effect	NOUN
cet-12770	34	9	diminished	diminish	VERB
cet-12770	34	10	after	after	ADP
cet-12770	34	11	about	about	ADV
cet-12770	34	12	12	12	NUM
cet-12770	34	13	h	h	NOUN
cet-12770	34	14	due	due	ADP
cet-12770	34	15	to	to	ADP
cet-12770	34	16	the	the	DET
cet-12770	34	17	development	development	NOUN
cet-12770	34	18	of	of	ADP
cet-12770	34	19	drug	drug	NOUN
cet-12770	34	20	resistance	resistance	NOUN
cet-12770	34	21	.	.	PUNCT
cet-12770	35	1	the	the	DET
cet-12770	35	2	current	current	ADJ
cet-12770	35	3	dosing	dose	VERB
cet-12770	35	4	strategy	strategy	NOUN
cet-12770	35	5	1279	1279	NUM
cet-12770	35	6	recommends	recommend	VERB
cet-12770	35	7	that	that	SCONJ
cet-12770	35	8	the	the	DET
cet-12770	35	9	patient	patient	NOUN
cet-12770	35	10	wear	wear	VERB
cet-12770	35	11	the	the	DET
cet-12770	35	12	patch	patch	NOUN
cet-12770	35	13	for	for	ADP
cet-12770	35	14	only	only	ADV
cet-12770	35	15	1/2	1/2	NUM
cet-12770	35	16	d	d	NOUN
cet-12770	35	17	and	and	CCONJ
cet-12770	35	18	wait	wait	VERB
cet-12770	35	19	for	for	SCONJ
cet-12770	35	20	resistance	resistance	NOUN
cet-12770	35	21	to	to	PART
cet-12770	35	22	recover	recover	VERB
cet-12770	35	23	(	(	PUNCT
cet-12770	35	24	parker	parker	PROPN
cet-12770	35	25	et.al	et.al	PROPN
cet-12770	35	26	.	.	PROPN
cet-12770	35	27	,	,	PUNCT
cet-12770	35	28	1995	1995	NUM
cet-12770	35	29	)	)	PUNCT
cet-12770	35	30	.	.	PUNCT
cet-12770	36	1	this	this	DET
cet-12770	36	2	therapy	therapy	NOUN
cet-12770	36	3	increases	increase	VERB
cet-12770	36	4	exercise	exercise	NOUN
cet-12770	36	5	duration	duration	NOUN
cet-12770	36	6	without	without	ADP
cet-12770	36	7	significant	significant	ADJ
cet-12770	36	8	evidence	evidence	NOUN
cet-12770	36	9	of	of	ADP
cet-12770	36	10	nitrate	nitrate	NOUN
cet-12770	36	11	tolerance	tolerance	NOUN
cet-12770	36	12	or	or	CCONJ
cet-12770	36	13	rebound	rebound	VERB
cet-12770	36	14	phenomena	phenomenon	NOUN
cet-12770	36	15	for	for	ADP
cet-12770	36	16	long	long	ADJ
cet-12770	36	17	time	time	NOUN
cet-12770	36	18	.	.	PUNCT
cet-12770	37	1	taking	take	VERB
cet-12770	37	2	this	this	DET
cet-12770	37	3	case	case	NOUN
cet-12770	37	4	as	as	ADP
cet-12770	37	5	an	an	DET
cet-12770	37	6	example	example	NOUN
cet-12770	37	7	,	,	PUNCT
cet-12770	37	8	the	the	DET
cet-12770	37	9	simulation	simulation	NOUN
cet-12770	37	10	results	result	NOUN
cet-12770	37	11	of	of	ADP
cet-12770	37	12	its	its	PRON
cet-12770	37	13	drug	drug	NOUN
cet-12770	37	14	concentration	concentration	NOUN
cet-12770	37	15	and	and	CCONJ
cet-12770	37	16	drug	drug	NOUN
cet-12770	37	17	effect	effect	NOUN
cet-12770	37	18	are	be	AUX
cet-12770	37	19	shown	show	VERB
cet-12770	37	20	in	in	ADP
cet-12770	37	21	the	the	DET
cet-12770	37	22	figure	figure	NOUN
cet-12770	37	23	2	2	NUM
cet-12770	37	24	,	,	PUNCT
cet-12770	37	25	and	and	CCONJ
cet-12770	37	26	it	it	PRON
cet-12770	37	27	can	can	AUX
cet-12770	37	28	provide	provide	VERB
cet-12770	37	29	effective	effective	ADJ
cet-12770	37	30	drug	drug	NOUN
cet-12770	37	31	effect	effect	NOUN
cet-12770	37	32	within	within	ADP
cet-12770	37	33	a	a	DET
cet-12770	37	34	certain	certain	ADJ
cet-12770	37	35	period	period	NOUN
cet-12770	37	36	of	of	ADP
cet-12770	37	37	time	time	NOUN
cet-12770	37	38	in	in	ADP
cet-12770	37	39	each	each	DET
cet-12770	37	40	cycle	cycle	NOUN
cet-12770	37	41	.	.	PUNCT
cet-12770	38	1	a	a	DET
cet-12770	38	2	b	b	NUM
cet-12770	38	3	figure	figure	NOUN
cet-12770	38	4	1	1	NUM
cet-12770	38	5	:	:	PUNCT
cet-12770	38	6	optimal	optimal	ADJ
cet-12770	38	7	stable	stable	ADJ
cet-12770	38	8	solution	solution	NOUN
cet-12770	38	9	drug	drug	NOUN
cet-12770	38	10	input	input	NOUN
cet-12770	38	11	strategy	strategy	NOUN
cet-12770	38	12	:	:	PUNCT
cet-12770	38	13	(	(	PUNCT
cet-12770	38	14	a	a	X
cet-12770	38	15	)	)	PUNCT
cet-12770	38	16	drug	drug	NOUN
cet-12770	38	17	input	input	NOUN
cet-12770	38	18	rate	rate	NOUN
cet-12770	38	19	and	and	CCONJ
cet-12770	38	20	concentration	concentration	NOUN
cet-12770	38	21	changing	change	VERB
cet-12770	38	22	,	,	PUNCT
cet-12770	38	23	(	(	PUNCT
cet-12770	38	24	b	b	X
cet-12770	38	25	)	)	PUNCT
cet-12770	38	26	drug	drug	NOUN
cet-12770	38	27	effect	effect	NOUN
cet-12770	38	28	.	.	PUNCT
cet-12770	39	1	a	a	DET
cet-12770	39	2	b	b	NOUN
cet-12770	39	3	c	c	X
cet-12770	39	4	figure	figure	NOUN
cet-12770	39	5	2	2	NUM
cet-12770	39	6	:	:	PUNCT
cet-12770	39	7	park	park	NOUN
cet-12770	39	8	input	input	NOUN
cet-12770	39	9	strategy	strategy	NOUN
cet-12770	39	10	:	:	PUNCT
cet-12770	39	11	(	(	PUNCT
cet-12770	39	12	a	a	X
cet-12770	39	13	)	)	PUNCT
cet-12770	39	14	drug	drug	NOUN
cet-12770	39	15	input	input	NOUN
cet-12770	39	16	rate	rate	NOUN
cet-12770	39	17	and	and	CCONJ
cet-12770	39	18	concentration	concentration	NOUN
cet-12770	39	19	change	change	NOUN
cet-12770	39	20	,	,	PUNCT
cet-12770	39	21	(	(	PUNCT
cet-12770	39	22	b	b	X
cet-12770	39	23	)	)	PUNCT
cet-12770	39	24	drug	drug	NOUN
cet-12770	39	25	effect	effect	NOUN
cet-12770	39	26	,	,	PUNCT
cet-12770	39	27	(	(	PUNCT
cet-12770	39	28	c	c	NOUN
cet-12770	39	29	)	)	PUNCT
cet-12770	39	30	concentration	concentration	NOUN
cet-12770	39	31	phase	phase	NOUN
cet-12770	39	32	diagram	diagram	NOUN
cet-12770	39	33	.	.	PUNCT
cet-12770	40	1	this	this	PRON
cet-12770	40	2	is	be	AUX
cet-12770	40	3	based	base	VERB
cet-12770	40	4	on	on	ADP
cet-12770	40	5	experimental	experimental	ADJ
cet-12770	40	6	observations	observation	NOUN
cet-12770	40	7	,	,	PUNCT
cet-12770	40	8	but	but	CCONJ
cet-12770	40	9	if	if	SCONJ
cet-12770	40	10	the	the	DET
cet-12770	40	11	pk	pk	PROPN
cet-12770	40	12	-	-	PUNCT
cet-12770	40	13	pd	pd	NOUN
cet-12770	40	14	model	model	NOUN
cet-12770	40	15	is	be	AUX
cet-12770	40	16	analysed	analyse	VERB
cet-12770	40	17	,	,	PUNCT
cet-12770	40	18	there	there	PRON
cet-12770	40	19	are	be	VERB
cet-12770	40	20	better	well	ADJ
cet-12770	40	21	drug	drug	NOUN
cet-12770	40	22	delivery	delivery	NOUN
cet-12770	40	23	strategies	strategy	NOUN
cet-12770	40	24	.	.	PUNCT
cet-12770	41	1	in	in	ADP
cet-12770	41	2	order	order	NOUN
cet-12770	41	3	to	to	PART
cet-12770	41	4	find	find	VERB
cet-12770	41	5	the	the	DET
cet-12770	41	6	optimal	optimal	ADJ
cet-12770	41	7	dosing	dosing	NOUN
cet-12770	41	8	trajectory	trajectory	NOUN
cet-12770	41	9	,	,	PUNCT
cet-12770	41	10	this	this	DET
cet-12770	41	11	problem	problem	NOUN
cet-12770	41	12	is	be	AUX
cet-12770	41	13	usually	usually	ADV
cet-12770	41	14	solved	solve	VERB
cet-12770	41	15	as	as	ADP
cet-12770	41	16	an	an	DET
cet-12770	41	17	optimal	optimal	ADJ
cet-12770	41	18	period	period	NOUN
cet-12770	41	19	control	control	NOUN
cet-12770	41	20	problem	problem	NOUN
cet-12770	41	21	with	with	ADP
cet-12770	41	22	uncertain	uncertain	ADJ
cet-12770	41	23	periods	period	NOUN
cet-12770	41	24	and	and	CCONJ
cet-12770	41	25	waveforms	waveform	NOUN
cet-12770	41	26	.	.	PUNCT
cet-12770	42	1	it	it	PRON
cet-12770	42	2	is	be	AUX
cet-12770	42	3	necessary	necessary	ADJ
cet-12770	42	4	to	to	PART
cet-12770	42	5	establish	establish	VERB
cet-12770	42	6	a	a	DET
cet-12770	42	7	performance	performance	NOUN
cet-12770	42	8	index	index	NOUN
cet-12770	42	9	and	and	CCONJ
cet-12770	42	10	then	then	ADV
cet-12770	42	11	find	find	VERB
cet-12770	42	12	out	out	ADP
cet-12770	42	13	the	the	DET
cet-12770	42	14	maximum	maximum	ADJ
cet-12770	42	15	value	value	NOUN
cet-12770	42	16	of	of	ADP
cet-12770	42	17	this	this	DET
cet-12770	42	18	index	index	NOUN
cet-12770	42	19	in	in	ADP
cet-12770	42	20	this	this	DET
cet-12770	42	21	case	case	NOUN
cet-12770	42	22	.	.	PUNCT
cet-12770	43	1	varigonda	varigonda	PROPN
cet-12770	43	2	et.al	et.al	PROPN
cet-12770	43	3	.	.	PUNCT
cet-12770	44	1	(	(	PUNCT
cet-12770	44	2	2004	2004	NUM
cet-12770	44	3	)	)	PUNCT
cet-12770	44	4	defines	define	VERB
cet-12770	44	5	such	such	DET
cet-12770	44	6	an	an	DET
cet-12770	44	7	index	index	NOUN
cet-12770	44	8	function	function	NOUN
cet-12770	44	9	in	in	ADP
cet-12770	44	10	eq(3	eq(3	PROPN
cet-12770	44	11	)	)	PUNCT
cet-12770	44	12	,	,	PUNCT
cet-12770	44	13	and	and	CCONJ
cet-12770	44	14	the	the	DET
cet-12770	44	15	optimal	optimal	ADJ
cet-12770	44	16	object	object	NOUN
cet-12770	44	17	𝐽𝐽	𝐽𝐽	PROPN
cet-12770	44	18	in	in	ADP
cet-12770	44	19	eq(4	eq(4	PROPN
cet-12770	44	20	)	)	PUNCT
cet-12770	44	21	.	.	PUNCT
cet-12770	45	1	they	they	PRON
cet-12770	45	2	used	use	VERB
cet-12770	45	3	fourier	fourier	NOUN
cet-12770	45	4	basis	basis	NOUN
cet-12770	45	5	functions	function	NOUN
cet-12770	45	6	to	to	PART
cet-12770	45	7	parameterize	parameterize	VERB
cet-12770	45	8	the	the	DET
cet-12770	45	9	input	input	NOUN
cet-12770	45	10	waveform	waveform	NOUN
cet-12770	45	11	.	.	PUNCT
cet-12770	46	1	the	the	DET
cet-12770	46	2	optimal	optimal	ADJ
cet-12770	46	3	periodic	periodic	ADJ
cet-12770	46	4	dosing	dose	VERB
cet-12770	46	5	strategy	strategy	NOUN
cet-12770	46	6	was	be	AUX
cet-12770	46	7	calculated	calculate	VERB
cet-12770	46	8	using	use	VERB
cet-12770	46	9	a	a	DET
cet-12770	46	10	flatness	flatness	NOUN
cet-12770	46	11	-	-	PUNCT
cet-12770	46	12	based	base	VERB
cet-12770	46	13	method	method	NOUN
cet-12770	46	14	and	and	CCONJ
cet-12770	46	15	a	a	DET
cet-12770	46	16	shooting	shooting	NOUN
cet-12770	46	17	method	method	NOUN
cet-12770	46	18	.	.	PUNCT
cet-12770	47	1	compared	compare	VERB
cet-12770	47	2	with	with	ADP
cet-12770	47	3	the	the	DET
cet-12770	47	4	current	current	ADJ
cet-12770	47	5	recommended	recommend	VERB
cet-12770	47	6	periodic	periodic	ADJ
cet-12770	47	7	operation	operation	NOUN
cet-12770	47	8	index	index	NOUN
cet-12770	47	9	about	about	ADP
cet-12770	47	10	j	j	PROPN
cet-12770	47	11	=	=	SYM
cet-12770	47	12	0.3052	0.3052	PROPN
cet-12770	47	13	,	,	PUNCT
cet-12770	47	14	the	the	DET
cet-12770	47	15	optimized	optimize	VERB
cet-12770	47	16	periodic	periodic	ADJ
cet-12770	47	17	operation	operation	NOUN
cet-12770	47	18	index	index	NOUN
cet-12770	47	19	is	be	AUX
cet-12770	47	20	about	about	ADP
cet-12770	47	21	j	j	PROPN
cet-12770	47	22	=	=	SYM
cet-12770	47	23	0.3537	0.3537	NUM
cet-12770	47	24	,	,	PUNCT
cet-12770	47	25	which	which	PRON
cet-12770	47	26	improves	improve	VERB
cet-12770	47	27	the	the	DET
cet-12770	47	28	average	average	ADJ
cet-12770	47	29	therapeutic	therapeutic	ADJ
cet-12770	47	30	effect	effect	NOUN
cet-12770	47	31	.	.	PUNCT
cet-12770	48	1	ghanaatpishe	ghanaatpishe	PROPN
cet-12770	48	2	et.al	et.al	PROPN
cet-12770	48	3	.	.	PUNCT
cet-12770	49	1	(	(	PUNCT
cet-12770	49	2	2017	2017	NUM
cet-12770	49	3	)	)	PUNCT
cet-12770	49	4	discussed	discuss	VERB
cet-12770	49	5	the	the	DET
cet-12770	49	6	online	online	ADJ
cet-12770	49	7	periodic	periodic	ADJ
cet-12770	49	8	optimization	optimization	NOUN
cet-12770	49	9	method	method	NOUN
cet-12770	49	10	in	in	ADP
cet-12770	49	11	the	the	DET
cet-12770	49	12	case	case	NOUN
cet-12770	49	13	of	of	ADP
cet-12770	49	14	parameter	parameter	NOUN
cet-12770	49	15	uncertainty	uncertainty	NOUN
cet-12770	49	16	,	,	PUNCT
cet-12770	49	17	and	and	CCONJ
cet-12770	49	18	the	the	DET
cet-12770	49	19	optimized	optimize	VERB
cet-12770	49	20	periodic	periodic	ADJ
cet-12770	49	21	operation	operation	NOUN
cet-12770	49	22	index	index	NOUN
cet-12770	49	23	was	be	AUX
cet-12770	49	24	also	also	ADV
cet-12770	49	25	improved	improve	VERB
cet-12770	49	26	relative	relative	ADJ
cet-12770	49	27	to	to	ADP
cet-12770	49	28	the	the	DET
cet-12770	49	29	recommended	recommend	VERB
cet-12770	49	30	periodic	periodic	ADJ
cet-12770	49	31	operation	operation	NOUN
cet-12770	49	32	index	index	NOUN
cet-12770	49	33	.	.	PUNCT
cet-12770	50	1	𝐼𝐼	𝐼𝐼	PROPN
cet-12770	50	2	=	=	PRON
cet-12770	50	3	(	(	PUNCT
cet-12770	50	4	𝐸𝐸	𝐸𝐸	PROPN
cet-12770	50	5	𝐸𝐸1⁄	𝐸𝐸1⁄	PROPN
cet-12770	50	6	)	)	PUNCT
cet-12770	50	7	𝛾𝛾	𝛾𝛾	ADV
cet-12770	50	8	(	(	PUNCT
cet-12770	50	9	1+(𝐸𝐸	1+(𝐸𝐸	NUM
cet-12770	50	10	𝐸𝐸1⁄	𝐸𝐸1⁄	NOUN
cet-12770	50	11	)	)	PUNCT
cet-12770	50	12	𝛾𝛾)(1+(𝐸𝐸	𝛾𝛾)(1+(𝐸𝐸	NOUN
cet-12770	50	13	𝐸𝐸2⁄	𝐸𝐸2⁄	NOUN
cet-12770	50	14	)	)	PUNCT
cet-12770	50	15	2𝛾𝛾	2𝛾𝛾	NOUN
cet-12770	50	16	)	)	PUNCT
cet-12770	50	17	(	(	PUNCT
cet-12770	50	18	3	3	X
cet-12770	50	19	)	)	PUNCT
cet-12770	50	20	𝐽𝐽	𝐽𝐽	NOUN
cet-12770	50	21	=	=	SYM
cet-12770	50	22	1	1	NUM
cet-12770	50	23	𝑇𝑇	𝑇𝑇	PROPN
cet-12770	50	24	∫	∫	NOUN
cet-12770	50	25	𝐼𝐼𝑇𝑇0	𝐼𝐼𝑇𝑇0	PROPN
cet-12770	50	26	𝑑𝑑𝑑𝑑	𝑑𝑑𝑑𝑑	NOUN
cet-12770	50	27	(	(	PUNCT
cet-12770	50	28	4	4	NUM
cet-12770	50	29	)	)	PUNCT
cet-12770	50	30	as	as	ADP
cet-12770	50	31	an	an	DET
cet-12770	50	32	optimal	optimal	ADJ
cet-12770	50	33	control	control	NOUN
cet-12770	50	34	problem	problem	NOUN
cet-12770	50	35	,	,	PUNCT
cet-12770	50	36	these	these	DET
cet-12770	50	37	methods	method	NOUN
cet-12770	50	38	provide	provide	VERB
cet-12770	50	39	a	a	DET
cet-12770	50	40	better	well	ADV
cet-12770	50	41	therapeutic	therapeutic	ADJ
cet-12770	50	42	effect	effect	NOUN
cet-12770	50	43	than	than	ADP
cet-12770	50	44	the	the	DET
cet-12770	50	45	periodic	periodic	ADJ
cet-12770	50	46	strategy	strategy	NOUN
cet-12770	50	47	observed	observe	VERB
cet-12770	50	48	in	in	ADP
cet-12770	50	49	the	the	DET
cet-12770	50	50	experiment	experiment	NOUN
cet-12770	50	51	,	,	PUNCT
cet-12770	50	52	but	but	CCONJ
cet-12770	50	53	the	the	DET
cet-12770	50	54	rhythm	rhythm	NOUN
cet-12770	50	55	of	of	ADP
cet-12770	50	56	the	the	DET
cet-12770	50	57	human	human	ADJ
cet-12770	50	58	body	body	NOUN
cet-12770	50	59	is	be	AUX
cet-12770	50	60	ignored	ignore	VERB
cet-12770	50	61	in	in	ADP
cet-12770	50	62	the	the	DET
cet-12770	50	63	established	establish	VERB
cet-12770	50	64	drug	drug	NOUN
cet-12770	50	65	delivery	delivery	NOUN
cet-12770	50	66	system	system	NOUN
cet-12770	50	67	.	.	PUNCT
cet-12770	51	1	the	the	DET
cet-12770	51	2	administration	administration	NOUN
cet-12770	51	3	cycle	cycle	NOUN
cet-12770	51	4	that	that	PRON
cet-12770	51	5	does	do	AUX
cet-12770	51	6	not	not	PART
cet-12770	51	7	conform	conform	VERB
cet-12770	51	8	to	to	ADP
cet-12770	51	9	the	the	DET
cet-12770	51	10	rhythm	rhythm	NOUN
cet-12770	51	11	of	of	ADP
cet-12770	51	12	the	the	DET
cet-12770	51	13	human	human	ADJ
cet-12770	51	14	body	body	NOUN
cet-12770	51	15	may	may	AUX
cet-12770	51	16	lead	lead	VERB
cet-12770	51	17	to	to	ADP
cet-12770	51	18	the	the	DET
cet-12770	51	19	change	change	NOUN
cet-12770	51	20	of	of	ADP
cet-12770	51	21	pharmacodynamic	pharmacodynamic	ADJ
cet-12770	51	22	relationship	relationship	NOUN
cet-12770	51	23	and	and	CCONJ
cet-12770	51	24	the	the	DET
cet-12770	51	25	rejection	rejection	NOUN
cet-12770	51	26	of	of	ADP
cet-12770	51	27	the	the	DET
cet-12770	51	28	patient	patient	NOUN
cet-12770	51	29	.	.	PUNCT
cet-12770	52	1	moreover	moreover	ADV
cet-12770	52	2	,	,	PUNCT
cet-12770	52	3	this	this	DET
cet-12770	52	4	optimal	optimal	ADJ
cet-12770	52	5	dosing	dose	VERB
cet-12770	52	6	scheme	scheme	NOUN
cet-12770	52	7	obtained	obtain	VERB
cet-12770	52	8	by	by	ADP
cet-12770	52	9	the	the	DET
cet-12770	52	10	fourier	fourier	ADJ
cet-12770	52	11	basis	basis	NOUN
cet-12770	52	12	function	function	NOUN
cet-12770	52	13	has	have	VERB
cet-12770	52	14	a	a	DET
cet-12770	52	15	large	large	ADJ
cet-12770	52	16	number	number	NOUN
cet-12770	52	17	of	of	ADP
cet-12770	52	18	complex	complex	ADJ
cet-12770	52	19	oscillations	oscillation	NOUN
cet-12770	52	20	,	,	PUNCT
cet-12770	52	21	which	which	PRON
cet-12770	52	22	is	be	AUX
cet-12770	52	23	difficult	difficult	ADJ
cet-12770	52	24	to	to	PART
cet-12770	52	25	achieve	achieve	VERB
cet-12770	52	26	through	through	ADP
cet-12770	52	27	drug	drug	NOUN
cet-12770	52	28	design	design	NOUN
cet-12770	52	29	(	(	PUNCT
cet-12770	52	30	mclean	mclean	NOUN
cet-12770	52	31	and	and	CCONJ
cet-12770	52	32	zhan	zhan	PROPN
cet-12770	52	33	,	,	PUNCT
cet-12770	52	34	2021	2021	NUM
cet-12770	52	35	)	)	PUNCT
cet-12770	52	36	.	.	PUNCT
cet-12770	53	1	this	this	DET
cet-12770	53	2	administration	administration	NOUN
cet-12770	53	3	trajectory	trajectory	NOUN
cet-12770	53	4	requires	require	VERB
cet-12770	53	5	complex	complex	ADJ
cet-12770	53	6	control	control	NOUN
cet-12770	53	7	equipment	equipment	NOUN
cet-12770	53	8	and	and	CCONJ
cet-12770	53	9	can	can	AUX
cet-12770	53	10	not	not	PART
cet-12770	53	11	be	be	AUX
cet-12770	53	12	achieved	achieve	VERB
cet-12770	53	13	using	use	VERB
cet-12770	53	14	currently	currently	ADV
cet-12770	53	15	commonly	commonly	ADV
cet-12770	53	16	used	use	VERB
cet-12770	53	17	sustained	sustain	VERB
cet-12770	53	18	-	-	PUNCT
cet-12770	53	19	release	release	NOUN
cet-12770	53	20	methods	method	NOUN
cet-12770	53	21	.	.	PUNCT
cet-12770	54	1	therefore	therefore	ADV
cet-12770	54	2	,	,	PUNCT
cet-12770	54	3	this	this	DET
cet-12770	54	4	problem	problem	NOUN
cet-12770	54	5	is	be	AUX
cet-12770	54	6	not	not	PART
cet-12770	54	7	an	an	DET
cet-12770	54	8	optimal	optimal	ADJ
cet-12770	54	9	period	period	NOUN
cet-12770	54	10	control	control	NOUN
cet-12770	54	11	problem	problem	NOUN
cet-12770	54	12	with	with	ADP
cet-12770	54	13	uncertain	uncertain	ADJ
cet-12770	54	14	periods	period	NOUN
cet-12770	54	15	and	and	CCONJ
cet-12770	54	16	waveform	waveform	VERB
cet-12770	54	17	.	.	PUNCT
cet-12770	55	1	in	in	ADP
cet-12770	55	2	this	this	DET
cet-12770	55	3	paper	paper	NOUN
cet-12770	55	4	,	,	PUNCT
cet-12770	55	5	the	the	DET
cet-12770	55	6	problem	problem	NOUN
cet-12770	55	7	of	of	ADP
cet-12770	55	8	optimal	optimal	ADJ
cet-12770	55	9	periodic	periodic	ADJ
cet-12770	55	10	operation	operation	NOUN
cet-12770	55	11	with	with	ADP
cet-12770	55	12	piecewise	piecewise	NOUN
cet-12770	55	13	function	function	NOUN
cet-12770	55	14	as	as	SCONJ
cet-12770	55	15	the	the	DET
cet-12770	55	16	optimal	optimal	ADJ
cet-12770	55	17	input	input	NOUN
cet-12770	55	18	is	be	AUX
cet-12770	55	19	presented	present	VERB
cet-12770	55	20	.	.	PUNCT
cet-12770	56	1	the	the	DET
cet-12770	56	2	paper	paper	NOUN
cet-12770	56	3	is	be	AUX
cet-12770	56	4	organized	organize	VERB
cet-12770	56	5	as	as	SCONJ
cet-12770	56	6	follows	follow	VERB
cet-12770	56	7	:	:	PUNCT
cet-12770	56	8	a	a	DET
cet-12770	56	9	pulse	pulse	NOUN
cet-12770	56	10	drug	drug	NOUN
cet-12770	56	11	delivery	delivery	NOUN
cet-12770	56	12	system	system	NOUN
cet-12770	56	13	is	be	AUX
cet-12770	56	14	introduced	introduce	VERB
cet-12770	56	15	in	in	ADP
cet-12770	56	16	the	the	DET
cet-12770	56	17	second	second	ADJ
cet-12770	56	18	section	section	NOUN
cet-12770	56	19	.	.	PUNCT
cet-12770	57	1	the	the	DET
cet-12770	57	2	system	system	NOUN
cet-12770	57	3	1280	1280	NUM
cet-12770	57	4	is	be	AUX
cet-12770	57	5	solved	solve	VERB
cet-12770	57	6	by	by	ADP
cet-12770	57	7	collocation	collocation	NOUN
cet-12770	57	8	method	method	NOUN
cet-12770	57	9	and	and	CCONJ
cet-12770	57	10	simulated	simulate	VERB
cet-12770	57	11	by	by	ADP
cet-12770	57	12	matlab	matlab	PROPN
cet-12770	57	13	in	in	ADP
cet-12770	57	14	the	the	DET
cet-12770	57	15	third	third	ADJ
cet-12770	57	16	section	section	NOUN
cet-12770	57	17	.	.	PUNCT
cet-12770	58	1	the	the	DET
cet-12770	58	2	fourth	fourth	ADJ
cet-12770	58	3	part	part	NOUN
cet-12770	58	4	is	be	AUX
cet-12770	58	5	the	the	DET
cet-12770	58	6	conclusion	conclusion	NOUN
cet-12770	58	7	of	of	ADP
cet-12770	58	8	this	this	DET
cet-12770	58	9	paper	paper	NOUN
cet-12770	58	10	.	.	PUNCT
cet-12770	59	1	2	2	X
cet-12770	59	2	.	.	X
cet-12770	59	3	establishment	establishment	NOUN
cet-12770	59	4	of	of	ADP
cet-12770	59	5	optimal	optimal	ADJ
cet-12770	59	6	pulse	pulse	NOUN
cet-12770	59	7	dosing	dose	VERB
cet-12770	59	8	strategy	strategy	NOUN
cet-12770	59	9	problems	problem	NOUN
cet-12770	59	10	as	as	ADP
cet-12770	59	11	a	a	DET
cet-12770	59	12	drug	drug	NOUN
cet-12770	59	13	delivery	delivery	NOUN
cet-12770	59	14	system	system	NOUN
cet-12770	59	15	,	,	PUNCT
cet-12770	59	16	its	its	PRON
cet-12770	59	17	periodic	periodic	ADJ
cet-12770	59	18	changes	change	NOUN
cet-12770	59	19	should	should	AUX
cet-12770	59	20	conform	conform	VERB
cet-12770	59	21	to	to	ADP
cet-12770	59	22	the	the	DET
cet-12770	59	23	human	human	ADJ
cet-12770	59	24	rhythm	rhythm	NOUN
cet-12770	59	25	.	.	PUNCT
cet-12770	60	1	this	this	PRON
cet-12770	60	2	means	mean	VERB
cet-12770	60	3	that	that	SCONJ
cet-12770	60	4	when	when	SCONJ
cet-12770	60	5	the	the	DET
cet-12770	60	6	system	system	NOUN
cet-12770	60	7	cycle	cycle	NOUN
cet-12770	60	8	is	be	AUX
cet-12770	60	9	t	t	NOUN
cet-12770	60	10	=	=	NUM
cet-12770	60	11	24	24	NUM
cet-12770	60	12	h	h	NOUN
cet-12770	60	13	,	,	PUNCT
cet-12770	60	14	it	it	PRON
cet-12770	60	15	is	be	AUX
cet-12770	60	16	most	most	ADV
cet-12770	60	17	suitable	suitable	ADJ
cet-12770	60	18	.	.	PUNCT
cet-12770	61	1	in	in	ADP
cet-12770	61	2	order	order	NOUN
cet-12770	61	3	to	to	PART
cet-12770	61	4	facilitate	facilitate	VERB
cet-12770	61	5	drug	drug	NOUN
cet-12770	61	6	design	design	NOUN
cet-12770	61	7	,	,	PUNCT
cet-12770	61	8	the	the	DET
cet-12770	61	9	input	input	NOUN
cet-12770	61	10	drug	drug	NOUN
cet-12770	61	11	concentration	concentration	NOUN
cet-12770	61	12	should	should	AUX
cet-12770	61	13	be	be	AUX
cet-12770	61	14	kept	keep	VERB
cet-12770	61	15	as	as	ADV
cet-12770	61	16	stable	stable	ADJ
cet-12770	61	17	as	as	ADP
cet-12770	61	18	possible	possible	ADJ
cet-12770	61	19	.	.	PUNCT
cet-12770	62	1	therefore	therefore	ADV
cet-12770	62	2	,	,	PUNCT
cet-12770	62	3	a	a	DET
cet-12770	62	4	drug	drug	NOUN
cet-12770	62	5	delivery	delivery	NOUN
cet-12770	62	6	system	system	NOUN
cet-12770	62	7	with	with	ADP
cet-12770	62	8	a	a	DET
cet-12770	62	9	24	24	NUM
cet-12770	62	10	h	h	NOUN
cet-12770	62	11	period	period	NOUN
cet-12770	62	12	of	of	ADP
cet-12770	62	13	pulsed	pulse	VERB
cet-12770	62	14	drug	drug	NOUN
cet-12770	62	15	trajectory	trajectory	NOUN
cet-12770	62	16	will	will	AUX
cet-12770	62	17	be	be	AUX
cet-12770	62	18	introduced	introduce	VERB
cet-12770	62	19	next	next	ADV
cet-12770	62	20	.	.	PUNCT
cet-12770	63	1	2.1	2.1	NUM
cet-12770	63	2	waveforms	waveform	NOUN
cet-12770	63	3	for	for	ADP
cet-12770	63	4	periodic	periodic	ADJ
cet-12770	63	5	dosing	dosing	NOUN
cet-12770	63	6	for	for	ADP
cet-12770	63	7	the	the	DET
cet-12770	63	8	system	system	NOUN
cet-12770	63	9	proposed	propose	VERB
cet-12770	63	10	by	by	ADP
cet-12770	63	11	eq(1	eq(1	PROPN
cet-12770	63	12	)	)	PUNCT
cet-12770	63	13	and	and	CCONJ
cet-12770	63	14	eq(2	eq(2	PROPN
cet-12770	63	15	)	)	PUNCT
cet-12770	63	16	,	,	PUNCT
cet-12770	63	17	steady	steady	ADJ
cet-12770	63	18	dosing	dosing	NOUN
cet-12770	63	19	will	will	AUX
cet-12770	63	20	lead	lead	VERB
cet-12770	63	21	to	to	ADP
cet-12770	63	22	an	an	DET
cet-12770	63	23	increase	increase	NOUN
cet-12770	63	24	in	in	ADP
cet-12770	63	25	drug	drug	NOUN
cet-12770	63	26	resistance	resistance	NOUN
cet-12770	63	27	and	and	CCONJ
cet-12770	63	28	thus	thus	ADV
cet-12770	63	29	fail	fail	VERB
cet-12770	63	30	to	to	PART
cet-12770	63	31	achieve	achieve	VERB
cet-12770	63	32	the	the	DET
cet-12770	63	33	minimum	minimum	ADJ
cet-12770	63	34	active	active	ADJ
cet-12770	63	35	drug	drug	NOUN
cet-12770	63	36	effect	effect	NOUN
cet-12770	63	37	.	.	PUNCT
cet-12770	64	1	it	it	PRON
cet-12770	64	2	is	be	AUX
cet-12770	64	3	necessary	necessary	ADJ
cet-12770	64	4	to	to	PART
cet-12770	64	5	analyze	analyze	VERB
cet-12770	64	6	the	the	DET
cet-12770	64	7	relation	relation	NOUN
cet-12770	64	8	of	of	ADP
cet-12770	64	9	𝑐𝑐	𝑐𝑐	NOUN
cet-12770	64	10	and	and	CCONJ
cet-12770	64	11	𝑎𝑎	𝑎𝑎	VERB
cet-12770	64	12	within	within	ADP
cet-12770	64	13	the	the	DET
cet-12770	64	14	effective	effective	ADJ
cet-12770	64	15	range	range	NOUN
cet-12770	64	16	of	of	ADP
cet-12770	64	17	the	the	DET
cet-12770	64	18	drug	drug	NOUN
cet-12770	64	19	,	,	PUNCT
cet-12770	64	20	as	as	SCONJ
cet-12770	64	21	shown	show	VERB
cet-12770	64	22	in	in	ADP
cet-12770	64	23	figure	figure	NOUN
cet-12770	64	24	3	3	NUM
cet-12770	64	25	.	.	PUNCT
cet-12770	65	1	a	a	DET
cet-12770	65	2	b	b	NUM
cet-12770	65	3	figure	figure	NOUN
cet-12770	65	4	3	3	NUM
cet-12770	65	5	.	.	X
cet-12770	65	6	relationship	relationship	NOUN
cet-12770	65	7	of	of	ADP
cet-12770	65	8	𝑐𝑐	𝑐𝑐	PROPN
cet-12770	65	9	,	,	PUNCT
cet-12770	65	10	𝑎𝑎	𝑎𝑎	NOUN
cet-12770	65	11	,	,	PUNCT
cet-12770	65	12	𝐸𝐸.	𝐸𝐸.	PRON
cet-12770	65	13	a.	a.	NOUN
cet-12770	65	14	three	three	NUM
cet-12770	65	15	-	-	PUNCT
cet-12770	65	16	dimensional	dimensional	ADJ
cet-12770	65	17	plot	plot	NOUN
cet-12770	65	18	,	,	PUNCT
cet-12770	65	19	b	b	NOUN
cet-12770	65	20	contour	contour	NOUN
cet-12770	65	21	plot	plot	NOUN
cet-12770	65	22	,	,	PUNCT
cet-12770	65	23	where	where	SCONJ
cet-12770	65	24	yellow	yellow	NOUN
cet-12770	65	25	represents	represent	VERB
cet-12770	65	26	the	the	DET
cet-12770	65	27	effective	effective	ADJ
cet-12770	65	28	concentration	concentration	NOUN
cet-12770	65	29	range	range	NOUN
cet-12770	65	30	.	.	PUNCT
cet-12770	66	1	it	it	PRON
cet-12770	66	2	can	can	AUX
cet-12770	66	3	be	be	AUX
cet-12770	66	4	seen	see	VERB
cet-12770	66	5	from	from	ADP
cet-12770	66	6	figure	figure	NOUN
cet-12770	66	7	3a	3a	NUM
cet-12770	66	8	that	that	SCONJ
cet-12770	66	9	when	when	SCONJ
cet-12770	66	10	antagonist	antagonist	NOUN
cet-12770	66	11	concentration	concentration	NOUN
cet-12770	66	12	is	be	AUX
cet-12770	66	13	high	high	ADJ
cet-12770	66	14	,	,	PUNCT
cet-12770	66	15	the	the	DET
cet-12770	66	16	drug	drug	NOUN
cet-12770	66	17	concentration	concentration	NOUN
cet-12770	66	18	has	have	VERB
cet-12770	66	19	less	less	ADJ
cet-12770	66	20	influence	influence	NOUN
cet-12770	66	21	on	on	ADP
cet-12770	66	22	drug	drug	NOUN
cet-12770	66	23	effect	effect	NOUN
cet-12770	66	24	.	.	PUNCT
cet-12770	67	1	this	this	PRON
cet-12770	67	2	means	mean	VERB
cet-12770	67	3	that	that	SCONJ
cet-12770	67	4	if	if	SCONJ
cet-12770	67	5	the	the	DET
cet-12770	67	6	antagonist	antagonist	NOUN
cet-12770	67	7	concentration	concentration	NOUN
cet-12770	67	8	is	be	AUX
cet-12770	67	9	within	within	ADP
cet-12770	67	10	a	a	DET
cet-12770	67	11	certain	certain	ADJ
cet-12770	67	12	range	range	NOUN
cet-12770	67	13	,	,	PUNCT
cet-12770	67	14	a	a	DET
cet-12770	67	15	particularly	particularly	ADV
cet-12770	67	16	high	high	ADJ
cet-12770	67	17	drug	drug	NOUN
cet-12770	67	18	concentration	concentration	NOUN
cet-12770	67	19	is	be	AUX
cet-12770	67	20	required	require	VERB
cet-12770	67	21	to	to	PART
cet-12770	67	22	produce	produce	VERB
cet-12770	67	23	an	an	DET
cet-12770	67	24	effective	effective	ADJ
cet-12770	67	25	drug	drug	NOUN
cet-12770	67	26	effect	effect	NOUN
cet-12770	67	27	.	.	PUNCT
cet-12770	68	1	the	the	DET
cet-12770	68	2	concentration	concentration	NOUN
cet-12770	68	3	of	of	ADP
cet-12770	68	4	the	the	DET
cet-12770	68	5	antagonist	antagonist	NOUN
cet-12770	68	6	should	should	AUX
cet-12770	68	7	be	be	AUX
cet-12770	68	8	controlled	control	VERB
cet-12770	68	9	as	as	ADV
cet-12770	68	10	low	low	ADJ
cet-12770	68	11	as	as	ADP
cet-12770	68	12	possible	possible	ADJ
cet-12770	68	13	from	from	ADP
cet-12770	68	14	the	the	DET
cet-12770	68	15	viewpoint	viewpoint	NOUN
cet-12770	68	16	of	of	ADP
cet-12770	68	17	reducing	reduce	VERB
cet-12770	68	18	drug	drug	NOUN
cet-12770	68	19	input	input	NOUN
cet-12770	68	20	.	.	PUNCT
cet-12770	69	1	it	it	PRON
cet-12770	69	2	can	can	AUX
cet-12770	69	3	be	be	AUX
cet-12770	69	4	seen	see	VERB
cet-12770	69	5	from	from	ADP
cet-12770	69	6	figure	figure	NOUN
cet-12770	69	7	3b	3b	NOUN
cet-12770	69	8	that	that	SCONJ
cet-12770	69	9	when	when	SCONJ
cet-12770	69	10	𝑐𝑐	𝑐𝑐	PROPN
cet-12770	69	11	∈	∈	PROPN
cet-12770	70	1	[	[	X
cet-12770	70	2	3/7,10	3/7,10	X
cet-12770	70	3	]	]	PUNCT
cet-12770	70	4	and	and	CCONJ
cet-12770	70	5	𝑎𝑎	𝑎𝑎	NOUN
cet-12770	70	6	∈	∈	PROPN
cet-12770	71	1	[	[	X
cet-12770	71	2	0,67/33	0,67/33	NOUN
cet-12770	71	3	]	]	X
cet-12770	71	4	,	,	PUNCT
cet-12770	71	5	the	the	DET
cet-12770	71	6	drug	drug	NOUN
cet-12770	71	7	is	be	AUX
cet-12770	71	8	in	in	ADP
cet-12770	71	9	the	the	DET
cet-12770	71	10	effective	effective	ADJ
cet-12770	71	11	range	range	NOUN
cet-12770	71	12	(	(	PUNCT
cet-12770	71	13	yellow	yellow	ADJ
cet-12770	71	14	interval	interval	NOUN
cet-12770	71	15	)	)	PUNCT
cet-12770	71	16	.	.	PUNCT
cet-12770	72	1	therefore	therefore	ADV
cet-12770	72	2	,	,	PUNCT
cet-12770	72	3	the	the	DET
cet-12770	72	4	concentration	concentration	NOUN
cet-12770	72	5	of	of	ADP
cet-12770	72	6	the	the	DET
cet-12770	72	7	antagonist	antagonist	NOUN
cet-12770	72	8	should	should	AUX
cet-12770	72	9	not	not	PART
cet-12770	72	10	exceed	exceed	VERB
cet-12770	72	11	the	the	DET
cet-12770	72	12	effective	effective	ADJ
cet-12770	72	13	control	control	NOUN
cet-12770	72	14	range	range	NOUN
cet-12770	72	15	during	during	ADP
cet-12770	72	16	the	the	DET
cet-12770	72	17	administration	administration	NOUN
cet-12770	72	18	process	process	NOUN
cet-12770	72	19	eq(5	eq(5	NOUN
cet-12770	72	20	)	)	PUNCT
cet-12770	72	21	.	.	PUNCT
cet-12770	73	1	𝑐𝑐	𝑐𝑐	NOUN
cet-12770	73	2	0.6(1	0.6(1	NUM
cet-12770	74	1	+	+	CCONJ
cet-12770	74	2	𝑐𝑐	𝑐𝑐	NOUN
cet-12770	74	3	)	)	PUNCT
cet-12770	75	1	−	−	PROPN
cet-12770	75	2	1	1	NUM
cet-12770	75	3	≤	≤	NOUN
cet-12770	75	4	a	a	DET
cet-12770	75	5	≤	≤	NOUN
cet-12770	76	1	𝑐𝑐	𝑐𝑐	ADP
cet-12770	76	2	0.3(1	0.3(1	PUNCT
cet-12770	77	1	+	+	NUM
cet-12770	77	2	𝑐𝑐	𝑐𝑐	NOUN
cet-12770	77	3	)	)	PUNCT
cet-12770	78	1	−	−	PROPN
cet-12770	78	2	1	1	NUM
cet-12770	78	3	(	(	PUNCT
cet-12770	78	4	5	5	NUM
cet-12770	78	5	)	)	PUNCT
cet-12770	78	6	according	accord	VERB
cet-12770	78	7	to	to	ADP
cet-12770	78	8	eq(1	eq(1	PROPN
cet-12770	78	9	)	)	PUNCT
cet-12770	78	10	,	,	PUNCT
cet-12770	78	11	𝑎𝑎	𝑎𝑎	VERB
cet-12770	78	12	tends	tend	VERB
cet-12770	78	13	to	to	ADP
cet-12770	78	14	𝑐𝑐	𝑐𝑐	NOUN
cet-12770	78	15	at	at	ADP
cet-12770	78	16	a	a	DET
cet-12770	78	17	slower	slow	ADJ
cet-12770	78	18	rate	rate	NOUN
cet-12770	78	19	than	than	ADP
cet-12770	78	20	𝑐𝑐.	𝑐𝑐.	NOUN
cet-12770	78	21	in	in	ADP
cet-12770	78	22	order	order	NOUN
cet-12770	78	23	to	to	PART
cet-12770	78	24	keep	keep	VERB
cet-12770	78	25	𝑎𝑎	𝑎𝑎	NOUN
cet-12770	78	26	within	within	ADP
cet-12770	78	27	the	the	DET
cet-12770	78	28	range	range	NOUN
cet-12770	78	29	,	,	PUNCT
cet-12770	78	30	it	it	PRON
cet-12770	78	31	is	be	AUX
cet-12770	78	32	necessary	necessary	ADJ
cet-12770	78	33	to	to	PART
cet-12770	78	34	reduce	reduce	VERB
cet-12770	78	35	𝑐𝑐	𝑐𝑐	NOUN
cet-12770	78	36	to	to	PART
cet-12770	78	37	restore	restore	VERB
cet-12770	78	38	𝑎𝑎	𝑎𝑎	NOUN
cet-12770	78	39	and	and	CCONJ
cet-12770	78	40	make	make	VERB
cet-12770	78	41	it	it	PRON
cet-12770	78	42	at	at	ADP
cet-12770	78	43	a	a	DET
cet-12770	78	44	smaller	small	ADJ
cet-12770	78	45	value	value	NOUN
cet-12770	78	46	,	,	PUNCT
cet-12770	78	47	so	so	SCONJ
cet-12770	78	48	that	that	SCONJ
cet-12770	78	49	𝐸𝐸	𝐸𝐸	PROPN
cet-12770	78	50	can	can	AUX
cet-12770	78	51	reach	reach	VERB
cet-12770	78	52	the	the	DET
cet-12770	78	53	effective	effective	ADJ
cet-12770	78	54	range	range	NOUN
cet-12770	78	55	within	within	ADP
cet-12770	78	56	a	a	DET
cet-12770	78	57	period	period	NOUN
cet-12770	78	58	of	of	ADP
cet-12770	78	59	time	time	NOUN
cet-12770	78	60	.	.	PUNCT
cet-12770	79	1	in	in	ADP
cet-12770	79	2	order	order	NOUN
cet-12770	79	3	to	to	PART
cet-12770	79	4	make	make	VERB
cet-12770	79	5	𝑎𝑎	𝑎𝑎	ADJ
cet-12770	79	6	decrease	decrease	NOUN
cet-12770	79	7	as	as	ADV
cet-12770	79	8	fast	fast	ADV
cet-12770	79	9	as	as	ADP
cet-12770	79	10	possible	possible	ADJ
cet-12770	79	11	to	to	PART
cet-12770	79	12	enter	enter	VERB
cet-12770	79	13	the	the	DET
cet-12770	79	14	next	next	ADJ
cet-12770	79	15	period	period	NOUN
cet-12770	79	16	,	,	PUNCT
cet-12770	79	17	𝑐𝑐	𝑐𝑐	PRON
cet-12770	79	18	should	should	AUX
cet-12770	79	19	be	be	AUX
cet-12770	79	20	decreased	decrease	VERB
cet-12770	79	21	as	as	ADV
cet-12770	79	22	soon	soon	ADV
cet-12770	79	23	as	as	ADP
cet-12770	79	24	possible	possible	ADJ
cet-12770	79	25	at	at	ADP
cet-12770	79	26	this	this	DET
cet-12770	79	27	time	time	NOUN
cet-12770	79	28	.	.	PUNCT
cet-12770	80	1	when	when	SCONJ
cet-12770	80	2	𝑢𝑢	𝑢𝑢	ADV
cet-12770	80	3	=	=	SYM
cet-12770	80	4	0	0	NUM
cet-12770	80	5	,	,	PUNCT
cet-12770	80	6	𝑐𝑐	𝑐𝑐	PRON
cet-12770	80	7	decreases	decrease	VERB
cet-12770	80	8	the	the	DET
cet-12770	80	9	fastest	fast	ADJ
cet-12770	80	10	.	.	PUNCT
cet-12770	81	1	therefore	therefore	ADV
cet-12770	81	2	,	,	PUNCT
cet-12770	81	3	the	the	DET
cet-12770	81	4	waveform	waveform	NOUN
cet-12770	81	5	of	of	ADP
cet-12770	81	6	the	the	DET
cet-12770	81	7	periodic	periodic	ADJ
cet-12770	81	8	dosing	dosing	NOUN
cet-12770	81	9	of	of	ADP
cet-12770	81	10	the	the	DET
cet-12770	81	11	drug	drug	NOUN
cet-12770	81	12	is	be	AUX
cet-12770	81	13	as	as	SCONJ
cet-12770	81	14	shown	show	VERB
cet-12770	81	15	in	in	ADP
cet-12770	81	16	eq(6	eq(6	PROPN
cet-12770	81	17	)	)	PUNCT
cet-12770	81	18	.	.	PUNCT
cet-12770	82	1	𝑢𝑢	𝑢𝑢	PRON
cet-12770	82	2	=	=	SYM
cet-12770	82	3	�	�	PROPN
cet-12770	82	4	𝑥𝑥	𝑥𝑥	ADP
cet-12770	82	5	,	,	PUNCT
cet-12770	82	6	0	0	NUM
cet-12770	82	7	<	<	X
cet-12770	82	8	𝑑𝑑	𝑑𝑑	PROPN
cet-12770	82	9	≤	≤	NUM
cet-12770	82	10	𝜏𝜏	𝜏𝜏	ADP
cet-12770	82	11	0	0	NUM
cet-12770	82	12	,	,	PUNCT
cet-12770	82	13	24	24	NUM
cet-12770	82	14	≥	≥	NOUN
cet-12770	82	15	𝑑𝑑	𝑑𝑑	VERB
cet-12770	82	16	>	>	PUNCT
cet-12770	82	17	𝜏𝜏	𝜏𝜏	PROPN
cet-12770	82	18	(	(	PUNCT
cet-12770	82	19	6	6	NUM
cet-12770	82	20	)	)	PUNCT
cet-12770	82	21	this	this	PRON
cet-12770	82	22	is	be	AUX
cet-12770	82	23	a	a	DET
cet-12770	82	24	drug	drug	NOUN
cet-12770	82	25	delivery	delivery	NOUN
cet-12770	82	26	system	system	NOUN
cet-12770	82	27	with	with	ADP
cet-12770	82	28	a	a	DET
cet-12770	82	29	pulsatile	pulsatile	NOUN
cet-12770	82	30	dosing	dosing	NOUN
cet-12770	82	31	strategy	strategy	NOUN
cet-12770	82	32	.	.	PUNCT
cet-12770	83	1	the	the	DET
cet-12770	83	2	system	system	NOUN
cet-12770	83	3	can	can	AUX
cet-12770	83	4	be	be	AUX
cet-12770	83	5	described	describe	VERB
cet-12770	83	6	as	as	ADP
cet-12770	83	7	eq(7	eq(7	NOUN
cet-12770	83	8	)	)	PUNCT
cet-12770	83	9	�	�	PROPN
cet-12770	83	10	𝑑𝑑𝑐𝑐1	𝑑𝑑𝑐𝑐1	NOUN
cet-12770	83	11	𝑑𝑑𝑑𝑑	𝑑𝑑𝑑𝑑	NOUN
cet-12770	84	1	=	=	PUNCT
cet-12770	85	1	𝑢𝑢	𝑢𝑢	INTJ
cet-12770	85	2	−	−	PROPN
cet-12770	86	1	𝑐𝑐	𝑐𝑐	PROPN
cet-12770	86	2	𝑑𝑑𝑎𝑎1	𝑑𝑑𝑎𝑎1	NOUN
cet-12770	86	3	𝑑𝑑𝑑𝑑	𝑑𝑑𝑑𝑑	NOUN
cet-12770	87	1	=	=	PUNCT
cet-12770	88	1	𝑘𝑘(𝑐𝑐	𝑘𝑘(𝑐𝑐	NOUN
cet-12770	88	2	−	−	NOUN
cet-12770	88	3	𝑎𝑎	𝑎𝑎	NOUN
cet-12770	88	4	)	)	PUNCT
cet-12770	88	5	，	，	PROPN
cet-12770	88	6	0	0	PUNCT
cet-12770	88	7	<	<	X
cet-12770	88	8	𝑑𝑑	𝑑𝑑	PROPN
cet-12770	88	9	≤	≤	NOUN
cet-12770	88	10	𝜏𝜏	𝜏𝜏	PROPN
cet-12770	88	11	；	；	PROPN
cet-12770	88	12	�	�	PROPN
cet-12770	88	13	𝑑𝑑𝑐𝑐2	𝑑𝑑𝑐𝑐2	PROPN
cet-12770	88	14	𝑑𝑑𝑑𝑑	𝑑𝑑𝑑𝑑	NOUN
cet-12770	88	15	=	=	SYM
cet-12770	88	16	−𝑐𝑐	−𝑐𝑐	NUM
cet-12770	88	17	𝑑𝑑𝑎𝑎2	𝑑𝑑𝑎𝑎2	NOUN
cet-12770	88	18	𝑑𝑑𝑑𝑑	𝑑𝑑𝑑𝑑	NOUN
cet-12770	89	1	=	=	PUNCT
cet-12770	90	1	𝑘𝑘(𝑐𝑐	𝑘𝑘(𝑐𝑐	NOUN
cet-12770	90	2	−	−	NOUN
cet-12770	90	3	𝑎𝑎	𝑎𝑎	NOUN
cet-12770	90	4	)	)	PUNCT
cet-12770	91	1	，	，	ADJ
cet-12770	91	2	𝜏𝜏	𝜏𝜏	VERB
cet-12770	91	3	<	<	X
cet-12770	91	4	𝑑𝑑	𝑑𝑑	X
cet-12770	91	5	≤	≤	NUM
cet-12770	91	6	24	24	NUM
cet-12770	91	7	(	(	PUNCT
cet-12770	91	8	7	7	NUM
cet-12770	91	9	)	)	SYM
cet-12770	91	10	2.2	2.2	NUM
cet-12770	91	11	establishment	establishment	NOUN
cet-12770	91	12	of	of	ADP
cet-12770	91	13	periodic	periodic	ADJ
cet-12770	91	14	system	system	NOUN
cet-12770	91	15	of	of	ADP
cet-12770	91	16	drug	drug	NOUN
cet-12770	91	17	delivery	delivery	NOUN
cet-12770	91	18	the	the	DET
cet-12770	91	19	system	system	NOUN
cet-12770	91	20	needs	need	VERB
cet-12770	91	21	to	to	PART
cet-12770	91	22	meet	meet	VERB
cet-12770	91	23	the	the	DET
cet-12770	91	24	effective	effective	ADJ
cet-12770	91	25	requirements	requirement	NOUN
cet-12770	91	26	,	,	PUNCT
cet-12770	91	27	that	that	PRON
cet-12770	91	28	means	mean	VERB
cet-12770	91	29	𝐸𝐸𝑚𝑚𝑑𝑑𝑚𝑚	𝐸𝐸𝑚𝑚𝑑𝑑𝑚𝑚	PROPN
cet-12770	91	30	>	>	X
cet-12770	91	31	0.3	0.3	NUM
cet-12770	91	32	.	.	PUNCT
cet-12770	92	1	according	accord	VERB
cet-12770	92	2	to	to	ADP
cet-12770	92	3	eq(6	eq(6	PROPN
cet-12770	92	4	)	)	PUNCT
cet-12770	92	5	,	,	PUNCT
cet-12770	92	6	𝐸𝐸(𝑑𝑑	𝐸𝐸(𝑑𝑑	NOUN
cet-12770	92	7	)	)	PUNCT
cet-12770	92	8	=	=	PUNCT
cet-12770	92	9	0.3	0.3	PRON
cet-12770	92	10	should	should	AUX
cet-12770	92	11	only	only	ADV
cet-12770	92	12	have	have	VERB
cet-12770	92	13	two	two	NUM
cet-12770	92	14	solutions	solution	NOUN
cet-12770	92	15	in	in	ADP
cet-12770	92	16	a	a	DET
cet-12770	92	17	period	period	NOUN
cet-12770	92	18	.	.	PUNCT
cet-12770	93	1	𝛼𝛼	𝛼𝛼	INTJ
cet-12770	93	2	and	and	CCONJ
cet-12770	93	3	𝛽𝛽	𝛽𝛽	ADV
cet-12770	93	4	should	should	AUX
cet-12770	93	5	satisfy	satisfy	VERB
cet-12770	93	6	eq(9	eq(9	PROPN
cet-12770	93	7	)	)	PUNCT
cet-12770	93	8	.	.	PUNCT
cet-12770	94	1	the	the	DET
cet-12770	94	2	certification	certification	NOUN
cet-12770	94	3	process	process	NOUN
cet-12770	94	4	is	be	AUX
cet-12770	94	5	in	in	ADP
cet-12770	94	6	the	the	DET
cet-12770	94	7	appendix	appendix	NOUN
cet-12770	94	8	.	.	PUNCT
cet-12770	95	1	e(α	e(α	NUM
cet-12770	95	2	)	)	PUNCT
cet-12770	95	3	=	=	SYM
cet-12770	95	4	e(𝛽𝛽	e(𝛽𝛽	PROPN
cet-12770	95	5	)	)	PUNCT
cet-12770	95	6	=	=	SYM
cet-12770	95	7	0.3，∆𝑑𝑑	0.3，∆𝑑𝑑	NOUN
cet-12770	95	8	=	=	PUNCT
cet-12770	95	9	𝛽𝛽	𝛽𝛽	ADP
cet-12770	95	10	−	−	PROPN
cet-12770	95	11	α	α	PROPN
cet-12770	95	12	(	(	PUNCT
cet-12770	95	13	8)	8)	NUM
cet-12770	95	14	α	α	NOUN
cet-12770	95	15	<	<	X
cet-12770	95	16	β	β	X
cet-12770	95	17	and	and	CCONJ
cet-12770	95	18	β	β	X
cet-12770	95	19	=	=	VERB
cet-12770	95	20	𝜏𝜏	𝜏𝜏	X
cet-12770	95	21	(	(	PUNCT
cet-12770	95	22	9	9	NUM
cet-12770	95	23	)	)	PUNCT
cet-12770	95	24	although	although	SCONJ
cet-12770	95	25	𝑢𝑢	𝑢𝑢	PRON
cet-12770	95	26	is	be	AUX
cet-12770	95	27	a	a	DET
cet-12770	95	28	piecewise	piecewise	NOUN
cet-12770	95	29	function	function	NOUN
cet-12770	95	30	,	,	PUNCT
cet-12770	95	31	𝑎𝑎	𝑎𝑎	NOUN
cet-12770	95	32	and	and	CCONJ
cet-12770	95	33	𝑐𝑐	𝑐𝑐	NOUN
cet-12770	95	34	are	be	AUX
cet-12770	95	35	continuous	continuous	ADJ
cet-12770	95	36	functions	function	NOUN
cet-12770	95	37	,	,	PUNCT
cet-12770	95	38	there	there	PRON
cet-12770	95	39	should	should	AUX
cet-12770	95	40	be	be	AUX
cet-12770	95	41	eq(10	eq(10	VERB
cet-12770	95	42	)	)	PUNCT
cet-12770	95	43	1281	1281	NUM
cet-12770	95	44	𝑐𝑐1(𝜏𝜏	𝑐𝑐1(𝜏𝜏	PUNCT
cet-12770	95	45	)	)	PUNCT
cet-12770	95	46	=	=	SYM
cet-12770	96	1	𝑐𝑐2(𝜏𝜏	𝑐𝑐2(𝜏𝜏	PROPN
cet-12770	96	2	)	)	PUNCT
cet-12770	96	3	;	;	PUNCT
cet-12770	96	4	𝑎𝑎1(𝜏𝜏	𝑎𝑎1(𝜏𝜏	X
cet-12770	96	5	)	)	PUNCT
cet-12770	96	6	=	=	SYM
cet-12770	96	7	𝑎𝑎2(𝜏𝜏	𝑎𝑎2(𝜏𝜏	NOUN
cet-12770	96	8	)	)	PUNCT
cet-12770	96	9	(	(	PUNCT
cet-12770	96	10	10	10	NUM
cet-12770	96	11	)	)	PUNCT
cet-12770	96	12	according	accord	VERB
cet-12770	96	13	to	to	ADP
cet-12770	96	14	eq(9	eq(9	PROPN
cet-12770	96	15	)	)	PUNCT
cet-12770	96	16	,	,	PUNCT
cet-12770	96	17	at	at	ADP
cet-12770	96	18	time	time	NOUN
cet-12770	96	19	𝜏𝜏	𝜏𝜏	ADJ
cet-12770	96	20	,	,	PUNCT
cet-12770	96	21	𝑎𝑎	𝑎𝑎	NOUN
cet-12770	96	22	and	and	CCONJ
cet-12770	96	23	𝑐𝑐	𝑐𝑐	PROPN
cet-12770	96	24	should	should	AUX
cet-12770	96	25	meet	meet	VERB
cet-12770	96	26	eq(11	eq(11	PROPN
cet-12770	96	27	)	)	PUNCT
cet-12770	96	28	𝑎𝑎(𝜏𝜏	𝑎𝑎(𝜏𝜏	PROPN
cet-12770	96	29	)	)	PUNCT
cet-12770	97	1	=	=	SYM
cet-12770	97	2	𝑐𝑐(𝜏𝜏	𝑐𝑐(𝜏𝜏	PROPN
cet-12770	97	3	)	)	PUNCT
cet-12770	97	4	0.3	0.3	NUM
cet-12770	97	5	�	�	PROPN
cet-12770	97	6	1	1	NUM
cet-12770	97	7	+	+	NUM
cet-12770	97	8	𝑐𝑐(𝜏𝜏	𝑐𝑐(𝜏𝜏	PROPN
cet-12770	97	9	)	)	PUNCT
cet-12770	97	10	�	�	PROPN
cet-12770	97	11	−	−	PROPN
cet-12770	97	12	1	1	NUM
cet-12770	97	13	(	(	PUNCT
cet-12770	97	14	11	11	NUM
cet-12770	97	15	)	)	PUNCT
cet-12770	97	16	although	although	SCONJ
cet-12770	97	17	the	the	DET
cet-12770	97	18	performance	performance	NOUN
cet-12770	97	19	index	index	NOUN
cet-12770	97	20	eq	eq	NOUN
cet-12770	97	21	(	(	PUNCT
cet-12770	97	22	3	3	NUM
cet-12770	97	23	)	)	PUNCT
cet-12770	97	24	proposed	propose	VERB
cet-12770	97	25	by	by	ADP
cet-12770	97	26	varigonda	varigonda	NOUN
cet-12770	97	27	et.al	et.al	PROPN
cet-12770	97	28	.	.	PUNCT
cet-12770	98	1	(	(	PUNCT
cet-12770	98	2	2004	2004	NUM
cet-12770	98	3	)	)	PUNCT
cet-12770	98	4	provides	provide	VERB
cet-12770	98	5	a	a	DET
cet-12770	98	6	method	method	NOUN
cet-12770	98	7	to	to	PART
cet-12770	98	8	solve	solve	VERB
cet-12770	98	9	the	the	DET
cet-12770	98	10	optimal	optimal	ADJ
cet-12770	98	11	cycle	cycle	NOUN
cet-12770	98	12	control	control	NOUN
cet-12770	98	13	under	under	ADP
cet-12770	98	14	the	the	DET
cet-12770	98	15	condition	condition	NOUN
cet-12770	98	16	of	of	ADP
cet-12770	98	17	cycle	cycle	NOUN
cet-12770	98	18	uncertainty	uncertainty	NOUN
cet-12770	98	19	,	,	PUNCT
cet-12770	98	20	and	and	CCONJ
cet-12770	98	21	has	have	AUX
cet-12770	98	22	achieved	achieve	VERB
cet-12770	98	23	appropriate	appropriate	ADJ
cet-12770	98	24	results	result	NOUN
cet-12770	98	25	,	,	PUNCT
cet-12770	98	26	it	it	PRON
cet-12770	98	27	is	be	AUX
cet-12770	98	28	not	not	PART
cet-12770	98	29	the	the	DET
cet-12770	98	30	ideal	ideal	ADJ
cet-12770	98	31	optimal	optimal	ADJ
cet-12770	98	32	parameter	parameter	NOUN
cet-12770	98	33	in	in	ADP
cet-12770	98	34	practice	practice	NOUN
cet-12770	98	35	.	.	PUNCT
cet-12770	99	1	∆𝑑𝑑	∆𝑑𝑑	PRON
cet-12770	99	2	is	be	AUX
cet-12770	99	3	chosen	choose	VERB
cet-12770	99	4	as	as	ADP
cet-12770	99	5	the	the	DET
cet-12770	99	6	optimal	optimal	ADJ
cet-12770	99	7	parameter	parameter	NOUN
cet-12770	99	8	,	,	PUNCT
cet-12770	99	9	the	the	DET
cet-12770	99	10	periodic	periodic	ADJ
cet-12770	99	11	optimization	optimization	NOUN
cet-12770	99	12	problem	problem	NOUN
cet-12770	99	13	can	can	AUX
cet-12770	99	14	be	be	AUX
cet-12770	99	15	described	describe	VERB
cet-12770	99	16	as	as	ADP
cet-12770	99	17	eq(12	eq(12	PROPN
cet-12770	99	18	)	)	PUNCT
cet-12770	99	19	.	.	PUNCT
cet-12770	100	1	𝑚𝑚𝑎𝑎𝑥𝑥	𝑚𝑚𝑎𝑎𝑥𝑥	VERB
cet-12770	100	2	𝐽𝐽	𝐽𝐽	PROPN
cet-12770	101	1	=	=	PRON
cet-12770	101	2	∆𝑑𝑑	∆𝑑𝑑	PROPN
cet-12770	101	3	𝑠𝑠.	𝑠𝑠.	VERB
cet-12770	101	4	𝑑𝑑.	𝑑𝑑.	NUM
cet-12770	101	5	𝑑𝑑𝑐𝑐1	𝑑𝑑𝑐𝑐1	NOUN
cet-12770	101	6	𝑑𝑑𝑑𝑑	𝑑𝑑𝑑𝑑	NOUN
cet-12770	102	1	=	=	PUNCT
cet-12770	103	1	𝑢𝑢	𝑢𝑢	INTJ
cet-12770	103	2	−	−	PROPN
cet-12770	104	1	𝑐𝑐	𝑐𝑐	PROPN
cet-12770	104	2	;	;	PUNCT
cet-12770	104	3	𝑑𝑑𝑎𝑎1	𝑑𝑑𝑎𝑎1	NOUN
cet-12770	104	4	𝑑𝑑𝑑𝑑	𝑑𝑑𝑑𝑑	NOUN
cet-12770	105	1	=	=	PUNCT
cet-12770	106	1	𝑘𝑘(𝑐𝑐	𝑘𝑘(𝑐𝑐	NOUN
cet-12770	106	2	−	−	NOUN
cet-12770	106	3	𝑎𝑎	𝑎𝑎	NOUN
cet-12770	106	4	)	)	PUNCT
cet-12770	106	5	;	;	PUNCT
cet-12770	106	6	𝑐𝑐(0	𝑐𝑐(0	NOUN
cet-12770	106	7	)	)	PUNCT
cet-12770	106	8	=	=	SYM
cet-12770	107	1	𝑐𝑐(𝑇𝑇);𝑎𝑎(0	𝑐𝑐(𝑇𝑇);𝑎𝑎(0	X
cet-12770	107	2	)	)	PUNCT
cet-12770	107	3	=	=	PUNCT
cet-12770	107	4	𝑎𝑎(𝑇𝑇	𝑎𝑎(𝑇𝑇	NOUN
cet-12770	107	5	)	)	PUNCT
cet-12770	107	6	(	(	PUNCT
cet-12770	107	7	12	12	NUM
cet-12770	107	8	)	)	PUNCT
cet-12770	107	9	3	3	NUM
cet-12770	107	10	.	.	PUNCT
cet-12770	107	11	numerical	numerical	ADJ
cet-12770	107	12	result	result	NOUN
cet-12770	107	13	for	for	ADP
cet-12770	107	14	periodic	periodic	ADJ
cet-12770	107	15	dosing	dose	VERB
cet-12770	107	16	strategy	strategy	NOUN
cet-12770	107	17	the	the	DET
cet-12770	107	18	optimal	optimal	ADJ
cet-12770	107	19	periodic	periodic	ADJ
cet-12770	107	20	control	control	NOUN
cet-12770	107	21	problem	problem	NOUN
cet-12770	107	22	needs	need	VERB
cet-12770	107	23	to	to	PART
cet-12770	107	24	be	be	AUX
cet-12770	107	25	determined	determine	VERB
cet-12770	107	26	by	by	ADP
cet-12770	107	27	the	the	DET
cet-12770	107	28	π	π	NOUN
cet-12770	107	29	-	-	NOUN
cet-12770	107	30	test	test	NOUN
cet-12770	107	31	.	.	PUNCT
cet-12770	108	1	however	however	ADV
cet-12770	108	2	,	,	PUNCT
cet-12770	108	3	the	the	DET
cet-12770	108	4	π	π	NOUN
cet-12770	108	5	-	-	NOUN
cet-12770	108	6	test	test	NOUN
cet-12770	108	7	considers	consider	VERB
cet-12770	108	8	the	the	DET
cet-12770	108	9	case	case	NOUN
cet-12770	108	10	of	of	ADP
cet-12770	108	11	a	a	DET
cet-12770	108	12	continuous	continuous	ADJ
cet-12770	108	13	function	function	NOUN
cet-12770	108	14	,	,	PUNCT
cet-12770	108	15	and	and	CCONJ
cet-12770	108	16	this	this	DET
cet-12770	108	17	part	part	NOUN
cet-12770	108	18	needs	need	VERB
cet-12770	108	19	to	to	PART
cet-12770	108	20	find	find	VERB
cet-12770	108	21	the	the	DET
cet-12770	108	22	best	good	ADJ
cet-12770	108	23	value	value	NOUN
cet-12770	108	24	of	of	ADP
cet-12770	108	25	the	the	DET
cet-12770	108	26	pulse	pulse	NOUN
cet-12770	108	27	period	period	NOUN
cet-12770	108	28	problem	problem	NOUN
cet-12770	108	29	.	.	PUNCT
cet-12770	109	1	therefore	therefore	ADV
cet-12770	109	2	,	,	PUNCT
cet-12770	109	3	it	it	PRON
cet-12770	109	4	can	can	AUX
cet-12770	109	5	not	not	PART
cet-12770	109	6	directly	directly	ADV
cet-12770	109	7	use	use	VERB
cet-12770	109	8	the	the	DET
cet-12770	109	9	optimal	optimal	ADJ
cet-12770	109	10	periodic	periodic	ADJ
cet-12770	109	11	control	control	NOUN
cet-12770	109	12	method	method	NOUN
cet-12770	109	13	to	to	PART
cet-12770	109	14	solve	solve	VERB
cet-12770	109	15	this	this	DET
cet-12770	109	16	problem	problem	NOUN
cet-12770	109	17	,	,	PUNCT
cet-12770	109	18	and	and	CCONJ
cet-12770	109	19	the	the	DET
cet-12770	109	20	periodic	periodic	ADJ
cet-12770	109	21	dosing	dose	VERB
cet-12770	109	22	strategy	strategy	NOUN
cet-12770	109	23	will	will	AUX
cet-12770	109	24	be	be	AUX
cet-12770	109	25	discussed	discuss	VERB
cet-12770	109	26	below	below	ADV
cet-12770	109	27	through	through	ADP
cet-12770	109	28	the	the	DET
cet-12770	109	29	collocation	collocation	NOUN
cet-12770	109	30	method	method	NOUN
cet-12770	109	31	.	.	PUNCT
cet-12770	110	1	3.1	3.1	NUM
cet-12770	110	2	theory	theory	NOUN
cet-12770	110	3	of	of	ADP
cet-12770	110	4	calculating	calculate	VERB
cet-12770	110	5	periodic	periodic	ADJ
cet-12770	110	6	solutions	solution	NOUN
cet-12770	110	7	by	by	ADP
cet-12770	110	8	collocation	collocation	NOUN
cet-12770	110	9	method	method	NOUN
cet-12770	110	10	it	it	PRON
cet-12770	110	11	is	be	AUX
cet-12770	110	12	assumed	assume	VERB
cet-12770	110	13	that	that	SCONJ
cet-12770	110	14	the	the	DET
cet-12770	110	15	general	general	ADJ
cet-12770	110	16	autonomous	autonomous	ADJ
cet-12770	110	17	system	system	NOUN
cet-12770	110	18	has	have	VERB
cet-12770	110	19	periodic	periodic	ADJ
cet-12770	110	20	solutions	solution	NOUN
cet-12770	110	21	with	with	ADP
cet-12770	110	22	period	period	NOUN
cet-12770	110	23	𝑇𝑇	𝑇𝑇	PROPN
cet-12770	110	24	,	,	PUNCT
cet-12770	110	25	and	and	CCONJ
cet-12770	110	26	its	its	PRON
cet-12770	110	27	mathematical	mathematical	ADJ
cet-12770	110	28	problem	problem	NOUN
cet-12770	110	29	is	be	AUX
cet-12770	110	30	shown	show	VERB
cet-12770	110	31	in	in	ADP
cet-12770	110	32	eq(13	eq(13	NOUN
cet-12770	110	33	)	)	PUNCT
cet-12770	110	34	.	.	PUNCT
cet-12770	111	1	𝑑𝑑𝑥𝑥	𝑑𝑑𝑥𝑥	NOUN
cet-12770	111	2	𝑑𝑑𝑑𝑑	𝑑𝑑𝑑𝑑	NOUN
cet-12770	112	1	=	=	SYM
cet-12770	112	2	𝑓𝑓(𝑥𝑥	𝑓𝑓(𝑥𝑥	PROPN
cet-12770	112	3	)	)	PUNCT
cet-12770	112	4	𝑥𝑥|𝑑𝑑=0	𝑥𝑥|𝑑𝑑=0	NOUN
cet-12770	112	5	=	=	NOUN
cet-12770	112	6	𝑥𝑥|𝑑𝑑=𝑇𝑇	𝑥𝑥|𝑑𝑑=𝑇𝑇	X
cet-12770	112	7	(	(	PUNCT
cet-12770	112	8	13	13	NUM
cet-12770	112	9	)	)	PUNCT
cet-12770	112	10	where	where	SCONJ
cet-12770	112	11	𝑥𝑥	𝑥𝑥	ADP
cet-12770	112	12	∈	∈	PROPN
cet-12770	112	13	𝑅𝑅𝑛𝑛	𝑅𝑅𝑛𝑛	ADV
cet-12770	112	14	is	be	AUX
cet-12770	112	15	an	an	DET
cet-12770	112	16	n	n	ADV
cet-12770	112	17	-	-	PUNCT
cet-12770	112	18	dimensional	dimensional	ADJ
cet-12770	112	19	variable	variable	ADJ
cet-12770	112	20	matrix	matrix	NOUN
cet-12770	112	21	,	,	PUNCT
cet-12770	112	22	𝑓𝑓(𝑥𝑥	𝑓𝑓(𝑥𝑥	PROPN
cet-12770	112	23	):	):	PUNCT
cet-12770	112	24	𝑅𝑅𝑛𝑛	𝑅𝑅𝑛𝑛	PROPN
cet-12770	112	25	→	→	PUNCT
cet-12770	112	26	𝑅𝑅𝑛𝑛	𝑅𝑅𝑛𝑛	SCONJ
cet-12770	112	27	is	be	AUX
cet-12770	112	28	a	a	DET
cet-12770	112	29	nonlinear	nonlinear	ADJ
cet-12770	112	30	mapping	mapping	NOUN
cet-12770	112	31	.	.	PUNCT
cet-12770	113	1	it	it	PRON
cet-12770	113	2	can	can	AUX
cet-12770	113	3	become	become	VERB
cet-12770	113	4	a	a	DET
cet-12770	113	5	boundary	boundary	ADJ
cet-12770	113	6	value	value	NOUN
cet-12770	113	7	problem	problem	NOUN
cet-12770	113	8	(	(	PUNCT
cet-12770	113	9	bvp	bvp	PROPN
cet-12770	113	10	)	)	PUNCT
cet-12770	113	11	as	as	ADP
cet-12770	113	12	eq(14	eq(14	NOUN
cet-12770	113	13	)	)	PUNCT
cet-12770	113	14	.	.	PUNCT
cet-12770	114	1	�	�	PROPN
cet-12770	114	2	𝑑𝑑𝑥𝑥	𝑑𝑑𝑥𝑥	NOUN
cet-12770	114	3	𝑑𝑑𝜏𝜏	𝑑𝑑𝜏𝜏	NOUN
cet-12770	114	4	=	=	SYM
cet-12770	114	5	𝑇𝑇𝑓𝑓(𝑥𝑥	𝑇𝑇𝑓𝑓(𝑥𝑥	PROPN
cet-12770	114	6	)	)	PUNCT
cet-12770	114	7	𝑥𝑥|𝜏𝜏=0	𝑥𝑥|𝜏𝜏=0	NOUN
cet-12770	114	8	=	=	SYM
cet-12770	114	9	𝑥𝑥|𝜏𝜏=1	𝑥𝑥|𝜏𝜏=1	PROPN
cet-12770	114	10	,	,	PUNCT
cet-12770	114	11	𝜏𝜏	𝜏𝜏	ADJ
cet-12770	114	12	=	=	ADJ
cet-12770	114	13	𝑑𝑑/𝑇𝑇	𝑑𝑑/𝑇𝑇	X
cet-12770	114	14	∈	∈	PROPN
cet-12770	115	1	[	[	X
cet-12770	115	2	0	0	NUM
cet-12770	115	3	,	,	PUNCT
cet-12770	115	4	1	1	NUM
cet-12770	115	5	]	]	PUNCT
cet-12770	115	6	(	(	PUNCT
cet-12770	115	7	14	14	NUM
cet-12770	115	8	)	)	PUNCT
cet-12770	115	9	due	due	ADP
cet-12770	115	10	to	to	ADP
cet-12770	115	11	the	the	DET
cet-12770	115	12	piecewise	piecewise	NOUN
cet-12770	115	13	input	input	NOUN
cet-12770	115	14	function	function	NOUN
cet-12770	115	15	,	,	PUNCT
cet-12770	115	16	the	the	DET
cet-12770	115	17	model	model	NOUN
cet-12770	115	18	can	can	AUX
cet-12770	115	19	not	not	PART
cet-12770	115	20	obtain	obtain	VERB
cet-12770	115	21	a	a	DET
cet-12770	115	22	numerically	numerically	ADV
cet-12770	115	23	unique	unique	ADJ
cet-12770	115	24	solution	solution	NOUN
cet-12770	115	25	.	.	PUNCT
cet-12770	116	1	shooting	shoot	VERB
cet-12770	116	2	method	method	NOUN
cet-12770	116	3	and	and	CCONJ
cet-12770	116	4	finite	finite	ADJ
cet-12770	116	5	difference	difference	NOUN
cet-12770	116	6	method	method	NOUN
cet-12770	116	7	are	be	AUX
cet-12770	116	8	the	the	DET
cet-12770	116	9	common	common	ADJ
cet-12770	116	10	methods	method	NOUN
cet-12770	116	11	for	for	ADP
cet-12770	116	12	calculating	calculate	VERB
cet-12770	116	13	bvp	bvp	PROPN
cet-12770	116	14	problem	problem	NOUN
cet-12770	116	15	.	.	PUNCT
cet-12770	117	1	but	but	CCONJ
cet-12770	117	2	considering	consider	VERB
cet-12770	117	3	the	the	DET
cet-12770	117	4	periodic	periodic	ADJ
cet-12770	117	5	solution	solution	NOUN
cet-12770	117	6	of	of	ADP
cet-12770	117	7	initial	initial	ADJ
cet-12770	117	8	value	value	NOUN
cet-12770	117	9	sensitivity	sensitivity	NOUN
cet-12770	117	10	,	,	PUNCT
cet-12770	117	11	this	this	DET
cet-12770	117	12	paper	paper	NOUN
cet-12770	117	13	discusses	discuss	VERB
cet-12770	117	14	the	the	DET
cet-12770	117	15	application	application	NOUN
cet-12770	117	16	of	of	ADP
cet-12770	117	17	collocation	collocation	NOUN
cet-12770	117	18	method	method	NOUN
cet-12770	117	19	.	.	PUNCT
cet-12770	118	1	the	the	DET
cet-12770	118	2	idea	idea	NOUN
cet-12770	118	3	is	be	AUX
cet-12770	118	4	to	to	PART
cet-12770	118	5	approximate	approximate	VERB
cet-12770	118	6	the	the	DET
cet-12770	118	7	ode	ode	NOUN
cet-12770	118	8	in	in	ADP
cet-12770	118	9	eq(13	eq(13	NOUN
cet-12770	118	10	)	)	PUNCT
cet-12770	118	11	at	at	ADP
cet-12770	118	12	a	a	DET
cet-12770	118	13	specific	specific	ADJ
cet-12770	118	14	collocation	collocation	NOUN
cet-12770	118	15	point	point	NOUN
cet-12770	118	16	,	,	PUNCT
cet-12770	118	17	thus	thus	ADV
cet-12770	118	18	discretizing	discretize	VERB
cet-12770	118	19	the	the	DET
cet-12770	118	20	original	original	ADJ
cet-12770	118	21	problem	problem	NOUN
cet-12770	118	22	.	.	PUNCT
cet-12770	119	1	for	for	ADP
cet-12770	119	2	the	the	DET
cet-12770	119	3	bvp	bvp	PROPN
cet-12770	119	4	model	model	NOUN
cet-12770	119	5	of	of	ADP
cet-12770	119	6	a	a	DET
cet-12770	119	7	given	give	VERB
cet-12770	119	8	autonomous	autonomous	ADJ
cet-12770	119	9	system	system	NOUN
cet-12770	119	10	,	,	PUNCT
cet-12770	119	11	the	the	DET
cet-12770	119	12	optimal	optimal	ADJ
cet-12770	119	13	approximation	approximation	NOUN
cet-12770	119	14	method	method	NOUN
cet-12770	119	15	is	be	AUX
cet-12770	119	16	used	use	VERB
cet-12770	119	17	to	to	PART
cet-12770	119	18	obtain	obtain	VERB
cet-12770	119	19	the	the	DET
cet-12770	119	20	optimal	optimal	ADJ
cet-12770	119	21	numerical	numerical	ADJ
cet-12770	119	22	approximation	approximation	NOUN
cet-12770	119	23	under	under	ADP
cet-12770	119	24	the	the	DET
cet-12770	119	25	given	give	VERB
cet-12770	119	26	calculation	calculation	NOUN
cet-12770	119	27	amount	amount	NOUN
cet-12770	119	28	.	.	PUNCT
cet-12770	120	1	figure	figure	NOUN
cet-12770	120	2	4	4	NUM
cet-12770	120	3	.	.	PUNCT
cet-12770	120	4	location	location	NOUN
cet-12770	120	5	intervals	interval	NOUN
cet-12770	120	6	and	and	CCONJ
cet-12770	120	7	collocation	collocation	NOUN
cet-12770	120	8	points	point	NOUN
cet-12770	120	9	as	as	SCONJ
cet-12770	120	10	shown	show	VERB
cet-12770	120	11	in	in	ADP
cet-12770	120	12	figure	figure	NOUN
cet-12770	120	13	4	4	NUM
cet-12770	120	14	,	,	PUNCT
cet-12770	120	15	assuming	assume	VERB
cet-12770	120	16	at	at	ADP
cet-12770	120	17	a	a	DET
cet-12770	120	18	≤	≤	NUM
cet-12770	120	19	t	t	NOUN
cet-12770	120	20	≤	≤	NUM
cet-12770	120	21	b	b	NOUN
cet-12770	120	22	,	,	PUNCT
cet-12770	120	23	there	there	PRON
cet-12770	120	24	are	be	VERB
cet-12770	120	25	n	n	DET
cet-12770	120	26	collocation	collocation	NOUN
cet-12770	120	27	points	point	NOUN
cet-12770	120	28	,	,	PUNCT
cet-12770	120	29	in	in	ADP
cet-12770	120	30	which	which	PRON
cet-12770	120	31	the	the	DET
cet-12770	120	32	𝑖𝑖	𝑖𝑖	X
cet-12770	120	33	discrete	discrete	ADJ
cet-12770	120	34	interval	interval	NOUN
cet-12770	120	35	[	[	X
cet-12770	120	36	𝑑𝑑𝑖𝑖	𝑑𝑑𝑖𝑖	NOUN
cet-12770	120	37	,	,	PUNCT
cet-12770	120	38	𝑑𝑑𝑖𝑖	𝑑𝑑𝑖𝑖	NOUN
cet-12770	120	39	+	+	CCONJ
cet-12770	120	40	1	1	NUM
cet-12770	120	41	]	]	PUNCT
cet-12770	120	42	with	with	ADP
cet-12770	120	43	𝑘𝑘	𝑘𝑘	PROPN
cet-12770	120	44	−	−	NUM
cet-12770	120	45	1	1	NUM
cet-12770	120	46	order	order	NOUN
cet-12770	120	47	polynomial	polynomial	ADJ
cet-12770	120	48	𝑥𝑥𝜋𝜋	𝑥𝑥𝜋𝜋	NOUN
cet-12770	120	49	interpolation	interpolation	NOUN
cet-12770	120	50	conditions	condition	NOUN
cet-12770	120	51	(	(	PUNCT
cet-12770	120	52	eq(15	eq(15	NOUN
cet-12770	120	53	)	)	PUNCT
cet-12770	120	54	)	)	PUNCT
cet-12770	120	55	.	.	PUNCT
cet-12770	121	1	𝑥𝑥𝜋𝜋(𝑑𝑑𝑖𝑖	𝑥𝑥𝜋𝜋(𝑑𝑑𝑖𝑖	X
cet-12770	121	2	)	)	PUNCT
cet-12770	122	1	=	=	SYM
cet-12770	122	2	𝑥𝑥𝑖𝑖	𝑥𝑥𝑖𝑖	NOUN
cet-12770	122	3	,	,	PUNCT
cet-12770	122	4	𝑥𝑥𝜋𝜋′(𝑑𝑑𝑖𝑖	𝑥𝑥𝜋𝜋′(𝑑𝑑𝑖𝑖	PROPN
cet-12770	122	5	)	)	PUNCT
cet-12770	122	6	=	=	SYM
cet-12770	123	1	𝑓𝑓	𝑓𝑓	PROPN
cet-12770	123	2	�	�	PROPN
cet-12770	123	3	𝑥𝑥𝑖𝑖,𝑗𝑗	𝑥𝑥𝑖𝑖,𝑗𝑗	PUNCT
cet-12770	123	4	,	,	PUNCT
cet-12770	123	5	𝑢𝑢	𝑢𝑢	PROPN
cet-12770	123	6	�	�	PROPN
cet-12770	123	7	,	,	PUNCT
cet-12770	123	8	1	1	NUM
cet-12770	123	9	≤	≤	NUM
cet-12770	123	10	𝑖𝑖	𝑖𝑖	NOUN
cet-12770	123	11	≤	≤	NUM
cet-12770	123	12	𝑚𝑚	𝑚𝑚	ADP
cet-12770	123	13	,	,	PUNCT
cet-12770	123	14	1	1	NUM
cet-12770	123	15	≤	≤	NUM
cet-12770	123	16	𝑗𝑗	𝑗𝑗	ADP
cet-12770	123	17	≤	≤	ADJ
cet-12770	123	18	𝑛𝑛	𝑛𝑛	NOUN
cet-12770	123	19	(	(	PUNCT
cet-12770	123	20	15	15	NUM
cet-12770	123	21	)	)	PUNCT
cet-12770	123	22	𝑥𝑥𝜋𝜋(𝑑𝑑	𝑥𝑥𝜋𝜋(𝑑𝑑	NOUN
cet-12770	123	23	)	)	PUNCT
cet-12770	123	24	approximate	approximate	ADJ
cet-12770	123	25	solution	solution	NOUN
cet-12770	123	26	can	can	AUX
cet-12770	123	27	be	be	AUX
cet-12770	123	28	through	through	ADP
cet-12770	123	29	the	the	DET
cet-12770	123	30	initial	initial	ADJ
cet-12770	123	31	value	value	NOUN
cet-12770	123	32	for	for	ADP
cet-12770	123	33	𝑥𝑥𝜋𝜋(𝑑𝑑𝑖𝑖	𝑥𝑥𝜋𝜋(𝑑𝑑𝑖𝑖	NOUN
cet-12770	123	34	)	)	PUNCT
cet-12770	123	35	numerical	numerical	ADJ
cet-12770	123	36	description	description	NOUN
cet-12770	123	37	(	(	PUNCT
cet-12770	123	38	eq(16	eq(16	PROPN
cet-12770	123	39	)	)	PUNCT
cet-12770	123	40	)	)	PUNCT
cet-12770	123	41	.	.	PUNCT
cet-12770	124	1	𝑥𝑥𝜋𝜋(𝑑𝑑	𝑥𝑥𝜋𝜋(𝑑𝑑	NOUN
cet-12770	124	2	)	)	PUNCT
cet-12770	124	3	=	=	SYM
cet-12770	124	4	𝑥𝑥𝜋𝜋(𝑑𝑑𝑖𝑖	𝑥𝑥𝜋𝜋(𝑑𝑑𝑖𝑖	PROPN
cet-12770	124	5	)	)	PUNCT
cet-12770	125	1	+	+	NUM
cet-12770	125	2	∫	∫	PROPN
cet-12770	125	3	∑	∑	PROPN
cet-12770	125	4	𝑓𝑓	𝑓𝑓	PROPN
cet-12770	125	5	�	�	PROPN
cet-12770	125	6	𝑥𝑥𝑖𝑖,𝑗𝑗	𝑥𝑥𝑖𝑖,𝑗𝑗	PUNCT
cet-12770	125	7	,	,	PUNCT
cet-12770	125	8	𝑢𝑢𝑖𝑖,𝑗𝑗	𝑢𝑢𝑖𝑖,𝑗𝑗	NOUN
cet-12770	125	9	�	�	PROPN
cet-12770	125	10	𝑛𝑛	𝑛𝑛	PART
cet-12770	125	11	𝑗𝑗=1	𝑗𝑗=1	PROPN
cet-12770	125	12	𝐿𝐿𝑗𝑗(𝜉𝜉)𝑑𝑑	𝐿𝐿𝑗𝑗(𝜉𝜉)𝑑𝑑	NOUN
cet-12770	125	13	𝑑𝑑𝑖𝑖	𝑑𝑑𝑖𝑖	NOUN
cet-12770	125	14	𝑑𝑑𝜉𝜉	𝑑𝑑𝜉𝜉	NOUN
cet-12770	125	15	(	(	PUNCT
cet-12770	125	16	16	16	NUM
cet-12770	125	17	)	)	PUNCT
cet-12770	125	18	where	where	SCONJ
cet-12770	125	19	𝑥𝑥𝑖𝑖,𝑗𝑗	𝑥𝑥𝑖𝑖,𝑗𝑗	VERB
cet-12770	125	20	=	=	PRON
cet-12770	125	21	𝑥𝑥𝜋𝜋	𝑥𝑥𝜋𝜋	VERB
cet-12770	125	22	�	�	PROPN
cet-12770	125	23	𝑑𝑑𝑖𝑖，𝑗𝑗	𝑑𝑑𝑖𝑖，𝑗𝑗	PROPN
cet-12770	125	24	�	�	PROPN
cet-12770	125	25	,	,	PUNCT
cet-12770	125	26	𝐿𝐿𝑗𝑗(𝜉𝜉	𝐿𝐿𝑗𝑗(𝜉𝜉	NOUN
cet-12770	125	27	)	)	PUNCT
cet-12770	125	28	=	=	SYM
cet-12770	125	29	∏	∏	PROPN
cet-12770	125	30	𝜉𝜉−𝜉𝜉𝑘𝑘	𝜉𝜉−𝜉𝜉𝑘𝑘	PROPN
cet-12770	125	31	𝜉𝜉𝑗𝑗−𝜉𝜉𝑘𝑘	𝜉𝜉𝑗𝑗−𝜉𝜉𝑘𝑘	NOUN
cet-12770	125	32	𝑛𝑛	𝑛𝑛	VERB
cet-12770	125	33	𝑘𝑘=1,𝑘𝑘≠𝑗𝑗	𝑘𝑘=1,𝑘𝑘≠𝑗𝑗	ADV
cet-12770	125	34	,	,	PUNCT
cet-12770	125	35	𝜉𝜉	𝜉𝜉	PROPN
cet-12770	125	36	=	=	SYM
cet-12770	125	37	𝑑𝑑−𝑑𝑑𝑖𝑖	𝑑𝑑−𝑑𝑑𝑖𝑖	PROPN
cet-12770	125	38	ℎ𝑖𝑖	ℎ𝑖𝑖	NOUN
cet-12770	125	39	,	,	PUNCT
cet-12770	125	40	𝜉𝜉	𝜉𝜉	PROPN
cet-12770	125	41	∈	∈	PROPN
cet-12770	126	1	[	[	X
cet-12770	126	2	0,1	0,1	NUM
cet-12770	126	3	]	]	PUNCT
cet-12770	126	4	,	,	PUNCT
cet-12770	126	5	𝜉𝜉𝑗𝑗	𝜉𝜉𝑗𝑗	NOUN
cet-12770	126	6	=	=	SYM
cet-12770	126	7	𝑑𝑑𝑖𝑖,𝑗𝑗−𝑑𝑑𝑖𝑖	𝑑𝑑𝑖𝑖,𝑗𝑗−𝑑𝑑𝑖𝑖	NOUN
cet-12770	126	8	ℎ𝑖𝑖	ℎ𝑖𝑖	NOUN
cet-12770	126	9	,	,	PUNCT
cet-12770	126	10	ℎ𝑖𝑖	ℎ𝑖𝑖	PROPN
cet-12770	126	11	=	=	SYM
cet-12770	126	12	𝑑𝑑𝑖𝑖+1	𝑑𝑑𝑖𝑖+1	PROPN
cet-12770	126	13	−	−	PROPN
cet-12770	126	14	𝑑𝑑𝑖𝑖	𝑑𝑑𝑖𝑖	NOUN
cet-12770	126	15	(	(	PUNCT
cet-12770	126	16	17	17	NUM
cet-12770	126	17	)	)	PUNCT
cet-12770	126	18	the	the	DET
cet-12770	126	19	gaussian	gaussian	ADJ
cet-12770	126	20	integral	integral	NOUN
cet-12770	126	21	is	be	AUX
cet-12770	126	22	taken	take	VERB
cet-12770	126	23	as	as	ADP
cet-12770	126	24	the	the	DET
cet-12770	126	25	integral	integral	NOUN
cet-12770	126	26	of	of	ADP
cet-12770	126	27	[	[	X
cet-12770	126	28	0	0	NUM
cet-12770	126	29	,	,	PUNCT
cet-12770	126	30	1	1	NUM
cet-12770	126	31	]	]	PUNCT
cet-12770	126	32	,	,	PUNCT
cet-12770	126	33	and	and	CCONJ
cet-12770	126	34	the	the	DET
cet-12770	126	35	integral	integral	ADJ
cet-12770	126	36	point	point	NOUN
cet-12770	126	37	is	be	AUX
cet-12770	126	38	taken	take	VERB
cet-12770	126	39	as	as	ADP
cet-12770	126	40	the	the	DET
cet-12770	126	41	collocation	collocation	NOUN
cet-12770	126	42	point	point	NOUN
cet-12770	126	43	.	.	PUNCT
cet-12770	127	1	two	two	NUM
cet-12770	127	2	sets	set	NOUN
cet-12770	127	3	of	of	ADP
cet-12770	127	4	discrete	discrete	ADJ
cet-12770	127	5	equations	equation	NOUN
cet-12770	127	6	(	(	PUNCT
cet-12770	127	7	eq(18	eq(18	PROPN
cet-12770	127	8	)	)	PUNCT
cet-12770	127	9	)	)	PUNCT
cet-12770	127	10	are	be	AUX
cet-12770	127	11	obtained	obtain	VERB
cet-12770	127	12	.	.	PUNCT
cet-12770	128	1	𝑥𝑥𝜋𝜋	𝑥𝑥𝜋𝜋	PROPN
cet-12770	128	2	�	�	PROPN
cet-12770	128	3	𝑑𝑑𝑖𝑖,𝑗𝑗	𝑑𝑑𝑖𝑖,𝑗𝑗	NOUN
cet-12770	128	4	�	�	PROPN
cet-12770	128	5	=	=	PUNCT
cet-12770	128	6	𝑥𝑥𝑖𝑖	𝑥𝑥𝑖𝑖	NOUN
cet-12770	128	7	+	+	CCONJ
cet-12770	128	8	ℎ𝑖𝑖	ℎ𝑖𝑖	NOUN
cet-12770	128	9	∑	∑	PUNCT
cet-12770	128	10	𝛼𝛼𝑗𝑗𝑘𝑘𝑓𝑓(𝑥𝑥𝑖𝑖𝑘𝑘)𝑛𝑛	𝛼𝛼𝑗𝑗𝑘𝑘𝑓𝑓(𝑥𝑥𝑖𝑖𝑘𝑘)𝑛𝑛	PROPN
cet-12770	128	11	𝑘𝑘=1	𝑘𝑘=1	PROPN
cet-12770	128	12	(	(	PUNCT
cet-12770	128	13	18	18	NUM
cet-12770	128	14	)	)	PUNCT
cet-12770	128	15	𝑥𝑥𝜋𝜋(𝑑𝑑𝑖𝑖+1	𝑥𝑥𝜋𝜋(𝑑𝑑𝑖𝑖+1	PROPN
cet-12770	128	16	)	)	PUNCT
cet-12770	128	17	=	=	SYM
cet-12770	128	18	𝑥𝑥𝑖𝑖	𝑥𝑥𝑖𝑖	NOUN
cet-12770	128	19	+	+	CCONJ
cet-12770	128	20	ℎ𝑖𝑖	ℎ𝑖𝑖	NOUN
cet-12770	128	21	∑	∑	PUNCT
cet-12770	128	22	𝛽𝛽𝑗𝑗𝑘𝑘𝑓𝑓(𝑥𝑥𝑖𝑖𝑘𝑘)𝑛𝑛	𝛽𝛽𝑗𝑗𝑘𝑘𝑓𝑓(𝑥𝑥𝑖𝑖𝑘𝑘)𝑛𝑛	PROPN
cet-12770	128	23	𝑘𝑘=1	𝑘𝑘=1	NUM
cet-12770	128	24	where	where	SCONJ
cet-12770	128	25	1282	1282	NUM
cet-12770	128	26	𝛼𝛼𝑗𝑗𝑘𝑘	𝛼𝛼𝑗𝑗𝑘𝑘	NOUN
cet-12770	128	27	=	=	SYM
cet-12770	128	28	∫	∫	PROPN
cet-12770	128	29	𝐿𝐿𝑗𝑗(𝜉𝜉)𝑑𝑑𝜉𝜉𝜉𝜉𝑘𝑘	𝐿𝐿𝑗𝑗(𝜉𝜉)𝑑𝑑𝜉𝜉𝜉𝜉𝑘𝑘	PROPN
cet-12770	128	30	0	0	NUM
cet-12770	128	31	,	,	PUNCT
cet-12770	128	32	𝛽𝛽𝑗𝑗𝑘𝑘	𝛽𝛽𝑗𝑗𝑘𝑘	PROPN
cet-12770	128	33	=	=	SYM
cet-12770	128	34	∫	∫	PROPN
cet-12770	128	35	𝐿𝐿𝑗𝑗(𝜉𝜉)𝑑𝑑𝜉𝜉1	𝐿𝐿𝑗𝑗(𝜉𝜉)𝑑𝑑𝜉𝜉1	PROPN
cet-12770	128	36	0	0	NUM
cet-12770	128	37	(	(	PUNCT
cet-12770	128	38	19	19	NUM
cet-12770	128	39	)	)	PUNCT
cet-12770	128	40	by	by	ADP
cet-12770	128	41	choosing	choose	VERB
cet-12770	128	42	the	the	DET
cet-12770	128	43	orthogonal	orthogonal	ADJ
cet-12770	128	44	configuration	configuration	NOUN
cet-12770	128	45	,	,	PUNCT
cet-12770	128	46	eq(18	eq(18	PROPN
cet-12770	128	47	)	)	PUNCT
cet-12770	128	48	can	can	AUX
cet-12770	128	49	have	have	VERB
cet-12770	128	50	the	the	DET
cet-12770	128	51	same	same	ADJ
cet-12770	128	52	matrix	matrix	NOUN
cet-12770	128	53	form	form	NOUN
cet-12770	128	54	as	as	ADP
cet-12770	128	55	runge	runge	NOUN
cet-12770	128	56	-	-	PUNCT
cet-12770	128	57	kutta	kutta	NOUN
cet-12770	128	58	algorithm	algorithm	NOUN
cet-12770	128	59	.	.	PUNCT
cet-12770	129	1	the	the	DET
cet-12770	129	2	𝛼𝛼𝑗𝑗𝑘𝑘	𝛼𝛼𝑗𝑗𝑘𝑘	PROPN
cet-12770	129	3	and	and	CCONJ
cet-12770	129	4	𝛽𝛽𝑗𝑗𝑘𝑘	𝛽𝛽𝑗𝑗𝑘𝑘	PROPN
cet-12770	129	5	in	in	ADP
cet-12770	129	6	eq(21	eq(21	PROPN
cet-12770	129	7	)	)	PUNCT
cet-12770	129	8	and	and	CCONJ
cet-12770	129	9	the	the	DET
cet-12770	129	10	collocation	collocation	NOUN
cet-12770	129	11	point	point	NOUN
cet-12770	129	12	𝜉𝜉	𝜉𝜉	PROPN
cet-12770	129	13	can	can	AUX
cet-12770	129	14	be	be	AUX
cet-12770	129	15	calculated	calculate	VERB
cet-12770	129	16	by	by	ADP
cet-12770	129	17	using	use	VERB
cet-12770	129	18	eq(19	eq(19	PROPN
cet-12770	129	19	)	)	PUNCT
cet-12770	129	20	.	.	PUNCT
cet-12770	130	1	to	to	PART
cet-12770	130	2	compute	compute	VERB
cet-12770	130	3	periodic	periodic	ADJ
cet-12770	130	4	solutions	solution	NOUN
cet-12770	130	5	for	for	ADP
cet-12770	130	6	a	a	DET
cet-12770	130	7	wide	wide	ADJ
cet-12770	130	8	range	range	NOUN
cet-12770	130	9	of	of	ADP
cet-12770	130	10	parameter	parameter	NOUN
cet-12770	130	11	values	value	NOUN
cet-12770	130	12	,	,	PUNCT
cet-12770	130	13	the	the	DET
cet-12770	130	14	largest	large	ADJ
cet-12770	130	15	possible	possible	ADJ
cet-12770	130	16	step	step	NOUN
cet-12770	130	17	size	size	NOUN
cet-12770	130	18	is	be	AUX
cet-12770	130	19	employed	employ	VERB
cet-12770	130	20	.	.	PUNCT
cet-12770	131	1	the	the	DET
cet-12770	131	2	simulation	simulation	NOUN
cet-12770	131	3	method	method	NOUN
cet-12770	131	4	is	be	AUX
cet-12770	131	5	fourth	fourth	ADJ
cet-12770	131	6	-	-	PUNCT
cet-12770	131	7	order	order	NOUN
cet-12770	131	8	runge	runge	NOUN
cet-12770	131	9	-	-	PUNCT
cet-12770	131	10	kutta	kutta	NOUN
cet-12770	131	11	method	method	NOUN
cet-12770	131	12	.	.	PUNCT
cet-12770	132	1	it	it	PRON
cet-12770	132	2	is	be	AUX
cet-12770	132	3	given	give	VERB
cet-12770	132	4	by	by	ADP
cet-12770	132	5	eq(20	eq(20	NOUN
cet-12770	132	6	)	)	PUNCT
cet-12770	132	7	.	.	PUNCT
cet-12770	133	1	𝑥𝑥𝑛𝑛+1	𝑥𝑥𝑛𝑛+1	PROPN
cet-12770	133	2	=	=	PUNCT
cet-12770	134	1	𝑥𝑥𝑛𝑛	𝑥𝑥𝑛𝑛	NOUN
cet-12770	135	1	+	+	CCONJ
cet-12770	135	2	ℎ	ℎ	X
cet-12770	135	3	6	6	NUM
cet-12770	135	4	(	(	PUNCT
cet-12770	135	5	𝑘𝑘1	𝑘𝑘1	X
cet-12770	135	6	+	+	PUNCT
cet-12770	135	7	2𝑘𝑘2	2𝑘𝑘2	NUM
cet-12770	135	8	+	+	CCONJ
cet-12770	135	9	2𝑘𝑘3	2𝑘𝑘3	NUM
cet-12770	135	10	+	+	CCONJ
cet-12770	135	11	𝑘𝑘4	𝑘𝑘4	NOUN
cet-12770	135	12	)	)	PUNCT
cet-12770	135	13	(	(	PUNCT
cet-12770	135	14	20	20	NUM
cet-12770	135	15	)	)	PUNCT
cet-12770	135	16	where	where	SCONJ
cet-12770	135	17	𝑘𝑘1	𝑘𝑘1	NOUN
cet-12770	135	18	=	=	SYM
cet-12770	135	19	𝑓𝑓(𝑑𝑑𝑛𝑛	𝑓𝑓(𝑑𝑑𝑛𝑛	PROPN
cet-12770	135	20	,	,	PUNCT
cet-12770	135	21	𝑥𝑥𝑛𝑛	𝑥𝑥𝑛𝑛	NUM
cet-12770	135	22	)	)	PUNCT
cet-12770	135	23	,	,	PUNCT
cet-12770	135	24	𝑘𝑘2	𝑘𝑘2	PROPN
cet-12770	135	25	=	=	PUNCT
cet-12770	135	26	𝑓𝑓	𝑓𝑓	PROPN
cet-12770	135	27	�	�	PROPN
cet-12770	135	28	𝑑𝑑𝑛𝑛	𝑑𝑑𝑛𝑛	NOUN
cet-12770	135	29	+	+	CCONJ
cet-12770	135	30	ℎ	ℎ	PROPN
cet-12770	135	31	2	2	NUM
cet-12770	135	32	,	,	PUNCT
cet-12770	135	33	𝑥𝑥𝑛𝑛	𝑥𝑥𝑛𝑛	NOUN
cet-12770	135	34	+	+	CCONJ
cet-12770	135	35	ℎ	ℎ	PROPN
cet-12770	135	36	2	2	NUM
cet-12770	135	37	𝑘𝑘1	𝑘𝑘1	NOUN
cet-12770	135	38	�	�	PROPN
cet-12770	135	39	,	,	PUNCT
cet-12770	135	40	𝑘𝑘3	𝑘𝑘3	NOUN
cet-12770	135	41	=	=	NOUN
cet-12770	135	42	𝑓𝑓	𝑓𝑓	PROPN
cet-12770	135	43	�	�	PROPN
cet-12770	135	44	𝑑𝑑𝑛𝑛	𝑑𝑑𝑛𝑛	NOUN
cet-12770	135	45	+	+	CCONJ
cet-12770	135	46	ℎ	ℎ	PROPN
cet-12770	135	47	2	2	NUM
cet-12770	135	48	,	,	PUNCT
cet-12770	135	49	𝑥𝑥𝑛𝑛	𝑥𝑥𝑛𝑛	NOUN
cet-12770	135	50	+	+	CCONJ
cet-12770	135	51	ℎ	ℎ	PROPN
cet-12770	135	52	2	2	NUM
cet-12770	135	53	𝑘𝑘2	𝑘𝑘2	PROPN
cet-12770	135	54	�	�	PROPN
cet-12770	135	55	,	,	PUNCT
cet-12770	135	56	𝑘𝑘4	𝑘𝑘4	NOUN
cet-12770	135	57	=	=	SYM
cet-12770	136	1	𝑓𝑓(𝑑𝑑𝑛𝑛	𝑓𝑓(𝑑𝑑𝑛𝑛	PROPN
cet-12770	136	2	+	+	NUM
cet-12770	136	3	ℎ	ℎ	PROPN
cet-12770	136	4	,	,	PUNCT
cet-12770	136	5	𝑥𝑥𝑛𝑛	𝑥𝑥𝑛𝑛	NOUN
cet-12770	136	6	+	+	CCONJ
cet-12770	136	7	ℎ𝑘𝑘3	ℎ𝑘𝑘3	PROPN
cet-12770	136	8	)	)	PUNCT
cet-12770	136	9	(	(	PUNCT
cet-12770	136	10	21	21	NUM
cet-12770	136	11	)	)	PUNCT
cet-12770	136	12	3.2	3.2	NUM
cet-12770	136	13	numerical	numerical	PROPN
cet-12770	136	14	simulation	simulation	PROPN
cet-12770	136	15	results	result	NOUN
cet-12770	136	16	of	of	ADP
cet-12770	136	17	impulsive	impulsive	ADJ
cet-12770	136	18	periodic	periodic	ADJ
cet-12770	136	19	dosing	dose	VERB
cet-12770	136	20	strategy	strategy	NOUN
cet-12770	136	21	according	accord	VERB
cet-12770	136	22	to	to	ADP
cet-12770	136	23	the	the	DET
cet-12770	136	24	collocation	collocation	NOUN
cet-12770	136	25	method	method	NOUN
cet-12770	136	26	,	,	PUNCT
cet-12770	136	27	the	the	DET
cet-12770	136	28	model	model	NOUN
cet-12770	136	29	can	can	AUX
cet-12770	136	30	be	be	AUX
cet-12770	136	31	obtained	obtain	VERB
cet-12770	136	32	to	to	PART
cet-12770	136	33	obtain	obtain	VERB
cet-12770	136	34	a	a	DET
cet-12770	136	35	pulsatile	pulsatile	ADJ
cet-12770	136	36	periodic	periodic	ADJ
cet-12770	136	37	drug	drug	NOUN
cet-12770	136	38	delivery	delivery	NOUN
cet-12770	136	39	strategy	strategy	NOUN
cet-12770	136	40	eq(22	eq(22	PROPN
cet-12770	136	41	)	)	PUNCT
cet-12770	136	42	.	.	PUNCT
cet-12770	137	1	𝑢𝑢	𝑢𝑢	PRON
cet-12770	137	2	=	=	SYM
cet-12770	137	3	�	�	PROPN
cet-12770	137	4	1.2	1.2	NUM
cet-12770	137	5	,	,	PUNCT
cet-12770	137	6	0	0	NUM
cet-12770	137	7	<	<	X
cet-12770	137	8	𝑑𝑑	𝑑𝑑	X
cet-12770	138	1	≤	≤	NUM
cet-12770	138	2	10	10	NUM
cet-12770	138	3	0	0	NUM
cet-12770	138	4	,	,	PUNCT
cet-12770	138	5	24	24	NUM
cet-12770	138	6	≥	≥	NUM
cet-12770	138	7	𝑑𝑑	𝑑𝑑	X
cet-12770	138	8	>	>	X
cet-12770	138	9	10	10	NUM
cet-12770	138	10	(	(	PUNCT
cet-12770	138	11	22	22	NUM
cet-12770	138	12	)	)	PUNCT
cet-12770	138	13	the	the	DET
cet-12770	138	14	numerical	numerical	PROPN
cet-12770	138	15	simulation	simulation	PROPN
cet-12770	138	16	results	result	NOUN
cet-12770	138	17	are	be	AUX
cet-12770	138	18	shown	show	VERB
cet-12770	138	19	in	in	ADP
cet-12770	138	20	figure	figure	NOUN
cet-12770	138	21	5	5	NUM
cet-12770	138	22	.	.	PUNCT
cet-12770	139	1	the	the	DET
cet-12770	139	2	𝑚𝑚𝑎𝑎𝑥𝑥	𝑚𝑚𝑎𝑎𝑥𝑥	ADJ
cet-12770	139	3	𝐽𝐽	𝐽𝐽	PROPN
cet-12770	139	4	=	=	PUNCT
cet-12770	139	5	∆𝑑𝑑	∆𝑑𝑑	PROPN
cet-12770	139	6	=	=	NOUN
cet-12770	139	7	9.43	9.43	NUM
cet-12770	139	8	.	.	PUNCT
cet-12770	140	1	a	a	DET
cet-12770	140	2	b	b	X
cet-12770	140	3	c	c	NOUN
cet-12770	140	4	d	d	NOUN
cet-12770	140	5	figure	figure	NOUN
cet-12770	140	6	5	5	NUM
cet-12770	140	7	:	:	PUNCT
cet-12770	140	8	impulsive	impulsive	ADJ
cet-12770	140	9	periodic	periodic	ADJ
cet-12770	140	10	dosing	dose	VERB
cet-12770	140	11	strateg	strateg	NOUN
cet-12770	140	12	:	:	PUNCT
cet-12770	140	13	(	(	PUNCT
cet-12770	140	14	a	a	X
cet-12770	140	15	)	)	PUNCT
cet-12770	140	16	drug	drug	NOUN
cet-12770	140	17	infusion	infusion	NOUN
cet-12770	140	18	rate	rate	NOUN
cet-12770	140	19	(	(	PUNCT
cet-12770	140	20	b	b	NOUN
cet-12770	140	21	)	)	PUNCT
cet-12770	140	22	𝑐𝑐	𝑐𝑐	NOUN
cet-12770	140	23	and	and	CCONJ
cet-12770	140	24	𝑎𝑎	𝑎𝑎	VERB
cet-12770	140	25	concentration	concentration	NOUN
cet-12770	140	26	changge	changge	NOUN
cet-12770	140	27	,	,	PUNCT
cet-12770	140	28	(	(	PUNCT
cet-12770	140	29	c	c	NOUN
cet-12770	140	30	)	)	PUNCT
cet-12770	140	31	drug	drug	NOUN
cet-12770	140	32	effect	effect	NOUN
cet-12770	140	33	,	,	PUNCT
cet-12770	140	34	(	(	PUNCT
cet-12770	140	35	d	d	NOUN
cet-12770	140	36	)	)	PUNCT
cet-12770	140	37	concentration	concentration	NOUN
cet-12770	140	38	phase	phase	NOUN
cet-12770	140	39	diagram	diagram	NOUN
cet-12770	140	40	.	.	PUNCT
cet-12770	141	1	as	as	SCONJ
cet-12770	141	2	can	can	AUX
cet-12770	141	3	be	be	AUX
cet-12770	141	4	seen	see	VERB
cet-12770	141	5	in	in	ADP
cet-12770	141	6	figure	figure	NOUN
cet-12770	141	7	5	5	NUM
cet-12770	141	8	,	,	PUNCT
cet-12770	141	9	the	the	DET
cet-12770	141	10	effective	effective	ADJ
cet-12770	141	11	concentration	concentration	NOUN
cet-12770	141	12	of	of	ADP
cet-12770	141	13	the	the	DET
cet-12770	141	14	drug	drug	NOUN
cet-12770	141	15	and	and	CCONJ
cet-12770	141	16	the	the	DET
cet-12770	141	17	concentration	concentration	NOUN
cet-12770	141	18	of	of	ADP
cet-12770	141	19	the	the	DET
cet-12770	141	20	antagonist	antagonist	NOUN
cet-12770	141	21	form	form	VERB
cet-12770	141	22	a	a	DET
cet-12770	141	23	limit	limit	NOUN
cet-12770	141	24	cycle	cycle	NOUN
cet-12770	141	25	.	.	PUNCT
cet-12770	142	1	this	this	PRON
cet-12770	142	2	shows	show	VERB
cet-12770	142	3	that	that	SCONJ
cet-12770	142	4	the	the	DET
cet-12770	142	5	scheme	scheme	NOUN
cet-12770	142	6	has	have	AUX
cet-12770	142	7	formed	form	VERB
cet-12770	142	8	a	a	DET
cet-12770	142	9	stable	stable	ADJ
cet-12770	142	10	cycle	cycle	NOUN
cet-12770	142	11	.	.	PUNCT
cet-12770	143	1	meanwhile	meanwhile	ADV
cet-12770	143	2	,	,	PUNCT
cet-12770	143	3	in	in	ADP
cet-12770	143	4	each	each	DET
cet-12770	143	5	cycle	cycle	NOUN
cet-12770	143	6	,	,	PUNCT
cet-12770	143	7	there	there	PRON
cet-12770	143	8	is	be	VERB
cet-12770	143	9	a	a	DET
cet-12770	143	10	9.43	9.43	NUM
cet-12770	143	11	h	h	NOUN
cet-12770	143	12	onset	onset	NOUN
cet-12770	143	13	time	time	NOUN
cet-12770	143	14	.	.	PUNCT
cet-12770	144	1	the	the	DET
cet-12770	144	2	results	result	NOUN
cet-12770	144	3	of	of	ADP
cet-12770	144	4	steady	steady	ADJ
cet-12770	144	5	-	-	PUNCT
cet-12770	144	6	state	state	NOUN
cet-12770	144	7	input	input	NOUN
cet-12770	144	8	are	be	AUX
cet-12770	144	9	not	not	PART
cet-12770	144	10	discussed	discuss	VERB
cet-12770	144	11	here	here	ADV
cet-12770	144	12	,	,	PUNCT
cet-12770	144	13	as	as	SCONJ
cet-12770	144	14	it	it	PRON
cet-12770	144	15	is	be	AUX
cet-12770	144	16	evident	evident	ADJ
cet-12770	144	17	that	that	SCONJ
cet-12770	144	18	there	there	PRON
cet-12770	144	19	is	be	VERB
cet-12770	144	20	no	no	DET
cet-12770	144	21	long	long	ADJ
cet-12770	144	22	-	-	PUNCT
cet-12770	144	23	term	term	NOUN
cet-12770	144	24	stable	stable	ADJ
cet-12770	144	25	periodic	periodic	ADJ
cet-12770	144	26	drug	drug	NOUN
cet-12770	144	27	effect	effect	NOUN
cet-12770	144	28	.	.	PUNCT
cet-12770	145	1	compared	compare	VERB
cet-12770	145	2	with	with	ADP
cet-12770	145	3	the	the	DET
cet-12770	145	4	experimental	experimental	ADJ
cet-12770	145	5	experience	experience	NOUN
cet-12770	145	6	method	method	NOUN
cet-12770	145	7	mentioned	mention	VERB
cet-12770	145	8	in	in	ADP
cet-12770	145	9	the	the	DET
cet-12770	145	10	introduction	introduction	NOUN
cet-12770	145	11	(	(	PUNCT
cet-12770	145	12	figure	figure	NOUN
cet-12770	145	13	2	2	NUM
cet-12770	145	14	)	)	PUNCT
cet-12770	145	15	,	,	PUNCT
cet-12770	145	16	the	the	DET
cet-12770	145	17	𝑚𝑚𝑎𝑎𝑥𝑥	𝑚𝑚𝑎𝑎𝑥𝑥	ADJ
cet-12770	145	18	𝐽𝐽	𝐽𝐽	PROPN
cet-12770	145	19	=	=	PUNCT
cet-12770	145	20	∆𝑑𝑑	∆𝑑𝑑	PROPN
cet-12770	145	21	=	=	NOUN
cet-12770	145	22	8.25	8.25	NUM
cet-12770	145	23	.	.	PUNCT
cet-12770	146	1	after	after	ADP
cet-12770	146	2	analysis	analysis	NOUN
cet-12770	146	3	and	and	CCONJ
cet-12770	146	4	optimization	optimization	NOUN
cet-12770	146	5	,	,	PUNCT
cet-12770	146	6	the	the	DET
cet-12770	146	7	effective	effective	ADJ
cet-12770	146	8	action	action	NOUN
cet-12770	146	9	time	time	NOUN
cet-12770	146	10	of	of	ADP
cet-12770	146	11	the	the	DET
cet-12770	146	12	drug	drug	NOUN
cet-12770	146	13	in	in	ADP
cet-12770	146	14	each	each	DET
cet-12770	146	15	cycle	cycle	NOUN
cet-12770	146	16	(	(	PUNCT
cet-12770	146	17	one	one	NUM
cet-12770	146	18	day	day	NOUN
cet-12770	146	19	)	)	PUNCT
cet-12770	146	20	was	be	AUX
cet-12770	146	21	prolonged	prolong	VERB
cet-12770	146	22	by	by	ADP
cet-12770	146	23	1.18	1.18	NUM
cet-12770	146	24	h.	h.	NOUN
cet-12770	146	25	compared	compare	VERB
cet-12770	146	26	with	with	ADP
cet-12770	146	27	the	the	DET
cet-12770	146	28	optimized	optimize	VERB
cet-12770	146	29	results	result	NOUN
cet-12770	146	30	of	of	ADP
cet-12770	146	31	other	other	ADJ
cet-12770	146	32	literature	literature	NOUN
cet-12770	146	33	,	,	PUNCT
cet-12770	146	34	the	the	DET
cet-12770	146	35	average	average	ADJ
cet-12770	146	36	curative	curative	ADJ
cet-12770	146	37	effect	effect	NOUN
cet-12770	146	38	of	of	ADP
cet-12770	146	39	each	each	DET
cet-12770	146	40	cycle	cycle	NOUN
cet-12770	146	41	is	be	AUX
cet-12770	146	42	relatively	relatively	ADV
cet-12770	146	43	low	low	ADJ
cet-12770	146	44	.	.	PUNCT
cet-12770	147	1	however	however	ADV
cet-12770	147	2	,	,	PUNCT
cet-12770	147	3	from	from	ADP
cet-12770	147	4	the	the	DET
cet-12770	147	5	effective	effective	ADJ
cet-12770	147	6	time	time	NOUN
cet-12770	147	7	of	of	ADP
cet-12770	147	8	each	each	DET
cet-12770	147	9	cycle	cycle	NOUN
cet-12770	147	10	,	,	PUNCT
cet-12770	147	11	the	the	DET
cet-12770	147	12	effective	effective	ADJ
cet-12770	147	13	time	time	NOUN
cet-12770	147	14	of	of	ADP
cet-12770	147	15	other	other	ADJ
cet-12770	147	16	literature	literature	NOUN
cet-12770	147	17	is	be	AUX
cet-12770	147	18	only	only	ADV
cet-12770	147	19	6	6	NUM
cet-12770	147	20	8	8	NUM
cet-12770	147	21	h	h	NOUN
cet-12770	147	22	per	per	ADP
cet-12770	147	23	cycle	cycle	NOUN
cet-12770	147	24	,	,	PUNCT
cet-12770	147	25	which	which	PRON
cet-12770	147	26	is	be	AUX
cet-12770	147	27	lower	low	ADJ
cet-12770	147	28	than	than	ADP
cet-12770	147	29	the	the	DET
cet-12770	147	30	optimization	optimization	NOUN
cet-12770	147	31	result	result	NOUN
cet-12770	147	32	.	.	PUNCT
cet-12770	148	1	the	the	DET
cet-12770	148	2	reason	reason	NOUN
cet-12770	148	3	for	for	ADP
cet-12770	148	4	this	this	DET
cet-12770	148	5	result	result	NOUN
cet-12770	148	6	is	be	AUX
cet-12770	148	7	that	that	SCONJ
cet-12770	148	8	other	other	ADJ
cet-12770	148	9	literature	literature	NOUN
cet-12770	148	10	shorten	shorten	VERB
cet-12770	148	11	the	the	DET
cet-12770	148	12	time	time	NOUN
cet-12770	148	13	of	of	ADP
cet-12770	148	14	each	each	DET
cet-12770	148	15	cycle	cycle	NOUN
cet-12770	148	16	,	,	PUNCT
cet-12770	148	17	so	so	SCONJ
cet-12770	148	18	as	as	SCONJ
cet-12770	148	19	to	to	PART
cet-12770	148	20	improve	improve	VERB
cet-12770	148	21	the	the	DET
cet-12770	148	22	average	average	ADJ
cet-12770	148	23	curative	curative	ADJ
cet-12770	148	24	effect	effect	NOUN
cet-12770	148	25	of	of	ADP
cet-12770	148	26	the	the	DET
cet-12770	148	27	cycle	cycle	NOUN
cet-12770	148	28	.	.	PUNCT
cet-12770	149	1	because	because	SCONJ
cet-12770	149	2	when	when	SCONJ
cet-12770	149	3	the	the	DET
cet-12770	149	4	drug	drug	NOUN
cet-12770	149	5	input	input	NOUN
cet-12770	149	6	rate	rate	NOUN
cet-12770	149	7	is	be	AUX
cet-12770	149	8	greater	great	ADJ
cet-12770	149	9	than	than	ADP
cet-12770	149	10	1	1	NUM
cet-12770	149	11	,	,	PUNCT
cet-12770	149	12	the	the	DET
cet-12770	149	13	drug	drug	NOUN
cet-12770	149	14	effect	effect	NOUN
cet-12770	149	15	will	will	AUX
cet-12770	149	16	reach	reach	VERB
cet-12770	149	17	its	its	PRON
cet-12770	149	18	maximum	maximum	ADJ
cet-12770	149	19	value	value	NOUN
cet-12770	149	20	within	within	ADP
cet-12770	149	21	6	6	NUM
cet-12770	149	22	h.	h.	NOUN
cet-12770	149	23	continuous	continuous	ADJ
cet-12770	149	24	infusion	infusion	NOUN
cet-12770	149	25	will	will	AUX
cet-12770	149	26	only	only	ADV
cet-12770	149	27	lead	lead	VERB
cet-12770	149	28	to	to	ADP
cet-12770	149	29	a	a	DET
cet-12770	149	30	rapid	rapid	ADJ
cet-12770	149	31	increase	increase	NOUN
cet-12770	149	32	in	in	ADP
cet-12770	149	33	antagonist	antagonist	NOUN
cet-12770	149	34	concentration	concentration	NOUN
cet-12770	149	35	,	,	PUNCT
cet-12770	149	36	thus	thus	ADV
cet-12770	149	37	reducing	reduce	VERB
cet-12770	149	38	the	the	DET
cet-12770	149	39	curative	curative	ADJ
cet-12770	149	40	effect	effect	NOUN
cet-12770	149	41	.	.	PUNCT
cet-12770	150	1	their	their	PRON
cet-12770	150	2	period	period	NOUN
cet-12770	150	3	is	be	AUX
cet-12770	150	4	usually	usually	ADV
cet-12770	150	5	15	15	NUM
cet-12770	150	6	18	18	NUM
cet-12770	150	7	h.	h.	NOUN
cet-12770	150	8	this	this	DET
cet-12770	150	9	kind	kind	NOUN
cet-12770	150	10	of	of	ADP
cet-12770	150	11	processing	processing	NOUN
cet-12770	150	12	is	be	AUX
cet-12770	150	13	suitable	suitable	ADJ
cet-12770	150	14	for	for	ADP
cet-12770	150	15	controlling	control	VERB
cet-12770	150	16	the	the	DET
cet-12770	150	17	results	result	NOUN
cet-12770	150	18	.	.	PUNCT
cet-12770	151	1	but	but	CCONJ
cet-12770	151	2	for	for	ADP
cet-12770	151	3	patients	patient	NOUN
cet-12770	151	4	,	,	PUNCT
cet-12770	151	5	the	the	DET
cet-12770	151	6	rapid	rapid	ADJ
cet-12770	151	7	cycles	cycle	NOUN
cet-12770	151	8	turnover	turnover	NOUN
cet-12770	151	9	means	mean	VERB
cet-12770	151	10	that	that	SCONJ
cet-12770	151	11	more	more	ADJ
cet-12770	151	12	operations	operation	NOUN
cet-12770	151	13	are	be	AUX
cet-12770	151	14	needed	need	VERB
cet-12770	151	15	.	.	PUNCT
cet-12770	152	1	for	for	ADP
cet-12770	152	2	systems	system	NOUN
cet-12770	152	3	that	that	PRON
cet-12770	152	4	require	require	VERB
cet-12770	152	5	long	long	ADJ
cet-12770	152	6	-	-	PUNCT
cet-12770	152	7	term	term	NOUN
cet-12770	152	8	medication	medication	NOUN
cet-12770	152	9	,	,	PUNCT
cet-12770	152	10	patients	patient	NOUN
cet-12770	152	11	may	may	AUX
cet-12770	152	12	have	have	VERB
cet-12770	152	13	a	a	DET
cet-12770	152	14	rebellious	rebellious	ADJ
cet-12770	152	15	attitude	attitude	NOUN
cet-12770	152	16	and	and	CCONJ
cet-12770	152	17	refuse	refuse	VERB
cet-12770	152	18	to	to	PART
cet-12770	152	19	treat	treat	VERB
cet-12770	152	20	them	they	PRON
cet-12770	152	21	.	.	PUNCT
cet-12770	153	1	in	in	ADP
cet-12770	153	2	addition	addition	NOUN
cet-12770	153	3	,	,	PUNCT
cet-12770	153	4	no	no	ADV
cet-12770	153	5	matter	matter	ADV
cet-12770	153	6	what	what	PRON
cet-12770	153	7	the	the	DET
cet-12770	153	8	waveform	waveform	NOUN
cet-12770	153	9	of	of	ADP
cet-12770	153	10	the	the	DET
cet-12770	153	11	drug	drug	NOUN
cet-12770	153	12	input	input	NOUN
cet-12770	153	13	is	be	AUX
cet-12770	153	14	,	,	PUNCT
cet-12770	153	15	there	there	PRON
cet-12770	153	16	is	be	VERB
cet-12770	153	17	no	no	DET
cet-12770	153	18	possibility	possibility	NOUN
cet-12770	153	19	of	of	ADP
cet-12770	153	20	long	long	ADJ
cet-12770	153	21	-	-	PUNCT
cet-12770	153	22	term	term	NOUN
cet-12770	153	23	stable	stable	ADJ
cet-12770	153	24	and	and	CCONJ
cet-12770	153	25	effective	effective	ADJ
cet-12770	153	26	drug	drug	NOUN
cet-12770	153	27	effect	effect	NOUN
cet-12770	153	28	.	.	PUNCT
cet-12770	154	1	this	this	PRON
cet-12770	154	2	means	mean	VERB
cet-12770	154	3	that	that	SCONJ
cet-12770	154	4	other	other	ADJ
cet-12770	154	5	drugs	drug	NOUN
cet-12770	154	6	need	need	VERB
cet-12770	154	7	to	to	PART
cet-12770	154	8	make	make	VERB
cet-12770	154	9	up	up	ADP
cet-12770	154	10	for	for	ADP
cet-12770	154	11	the	the	DET
cet-12770	154	12	lack	lack	NOUN
cet-12770	154	13	of	of	ADP
cet-12770	154	14	efficacy	efficacy	NOUN
cet-12770	154	15	during	during	ADP
cet-12770	154	16	the	the	DET
cet-12770	154	17	period	period	NOUN
cet-12770	154	18	when	when	SCONJ
cet-12770	154	19	the	the	DET
cet-12770	154	20	drug	drug	NOUN
cet-12770	154	21	is	be	AUX
cet-12770	154	22	not	not	PART
cet-12770	154	23	working	work	VERB
cet-12770	154	24	.	.	PUNCT
cet-12770	155	1	the	the	DET
cet-12770	155	2	segmented	segment	VERB
cet-12770	155	3	input	input	NOUN
cet-12770	155	4	provided	provide	VERB
cet-12770	155	5	herein	herein	NOUN
cet-12770	155	6	is	be	AUX
cet-12770	155	7	more	more	ADV
cet-12770	155	8	suitable	suitable	ADJ
cet-12770	155	9	for	for	ADP
cet-12770	155	10	co	co	NOUN
cet-12770	155	11	-	-	NOUN
cet-12770	155	12	administration	administration	NOUN
cet-12770	155	13	.	.	PUNCT
cet-12770	156	1	1283	1283	NUM
cet-12770	156	2	4	4	NUM
cet-12770	156	3	.	.	PUNCT
cet-12770	156	4	conclusions	conclusion	NOUN
cet-12770	156	5	in	in	ADP
cet-12770	156	6	this	this	DET
cet-12770	156	7	paper	paper	NOUN
cet-12770	156	8	,	,	PUNCT
cet-12770	156	9	a	a	DET
cet-12770	156	10	pulsatile	pulsatile	NOUN
cet-12770	156	11	drug	drug	NOUN
cet-12770	156	12	delivery	delivery	NOUN
cet-12770	156	13	system	system	NOUN
cet-12770	156	14	is	be	AUX
cet-12770	156	15	proposed	propose	VERB
cet-12770	156	16	based	base	VERB
cet-12770	156	17	on	on	ADP
cet-12770	156	18	a	a	DET
cet-12770	156	19	pk	pk	NOUN
cet-12770	156	20	-	-	PUNCT
cet-12770	156	21	pd	pd	NOUN
cet-12770	156	22	model	model	NOUN
cet-12770	156	23	of	of	ADP
cet-12770	156	24	tolerance	tolerance	NOUN
cet-12770	156	25	.	.	PUNCT
cet-12770	157	1	this	this	PRON
cet-12770	157	2	is	be	AUX
cet-12770	157	3	not	not	PART
cet-12770	157	4	a	a	DET
cet-12770	157	5	cycle	cycle	NOUN
cet-12770	157	6	solution	solution	NOUN
cet-12770	157	7	with	with	ADP
cet-12770	157	8	the	the	DET
cet-12770	157	9	best	good	ADJ
cet-12770	157	10	average	average	ADJ
cet-12770	157	11	efficacy	efficacy	NOUN
cet-12770	157	12	,	,	PUNCT
cet-12770	157	13	but	but	CCONJ
cet-12770	157	14	a	a	DET
cet-12770	157	15	dosing	dose	VERB
cet-12770	157	16	regimen	regiman	NOUN
cet-12770	157	17	that	that	PRON
cet-12770	157	18	conforms	conform	VERB
cet-12770	157	19	to	to	ADP
cet-12770	157	20	the	the	DET
cet-12770	157	21	rhythm	rhythm	NOUN
cet-12770	157	22	of	of	ADP
cet-12770	157	23	the	the	DET
cet-12770	157	24	body	body	NOUN
cet-12770	157	25	.	.	PUNCT
cet-12770	158	1	at	at	ADP
cet-12770	158	2	the	the	DET
cet-12770	158	3	same	same	ADJ
cet-12770	158	4	time	time	NOUN
cet-12770	158	5	,	,	PUNCT
cet-12770	158	6	this	this	PRON
cet-12770	158	7	pulsatile	pulsatile	NOUN
cet-12770	158	8	dosing	dose	VERB
cet-12770	158	9	regimen	regiman	NOUN
cet-12770	158	10	is	be	AUX
cet-12770	158	11	also	also	ADV
cet-12770	158	12	easy	easy	ADJ
cet-12770	158	13	to	to	PART
cet-12770	158	14	achieve	achieve	VERB
cet-12770	158	15	through	through	ADP
cet-12770	158	16	the	the	DET
cet-12770	158	17	design	design	NOUN
cet-12770	158	18	of	of	ADP
cet-12770	158	19	sustained	sustained	ADJ
cet-12770	158	20	drug	drug	NOUN
cet-12770	158	21	delivery	delivery	NOUN
cet-12770	158	22	.	.	PUNCT
cet-12770	159	1	the	the	DET
cet-12770	159	2	specific	specific	ADJ
cet-12770	159	3	optimal	optimal	ADJ
cet-12770	159	4	input	input	NOUN
cet-12770	159	5	result	result	NOUN
cet-12770	159	6	obtained	obtain	VERB
cet-12770	159	7	by	by	ADP
cet-12770	159	8	the	the	DET
cet-12770	159	9	collocation	collocation	NOUN
cet-12770	159	10	method	method	NOUN
cet-12770	159	11	is	be	AUX
cet-12770	159	12	shown	show	VERB
cet-12770	159	13	in	in	ADP
cet-12770	159	14	eq(23	eq(23	NOUN
cet-12770	159	15	)	)	PUNCT
cet-12770	159	16	.	.	PUNCT
cet-12770	160	1	stable	stable	ADJ
cet-12770	160	2	periodic	periodic	ADJ
cet-12770	160	3	results	result	NOUN
cet-12770	160	4	are	be	AUX
cet-12770	160	5	obtained	obtain	VERB
cet-12770	160	6	based	base	VERB
cet-12770	160	7	on	on	ADP
cet-12770	160	8	the	the	DET
cet-12770	160	9	model	model	NOUN
cet-12770	160	10	.	.	PUNCT
cet-12770	161	1	the	the	DET
cet-12770	161	2	results	result	NOUN
cet-12770	161	3	of	of	ADP
cet-12770	161	4	this	this	DET
cet-12770	161	5	study	study	NOUN
cet-12770	161	6	provide	provide	VERB
cet-12770	161	7	an	an	DET
cet-12770	161	8	easy	easy	ADJ
cet-12770	161	9	-	-	PUNCT
cet-12770	161	10	to	to	PART
cet-12770	161	11	-	-	PUNCT
cet-12770	161	12	realize	realize	VERB
cet-12770	161	13	solution	solution	NOUN
cet-12770	161	14	to	to	PART
cet-12770	161	15	solve	solve	VERB
cet-12770	161	16	the	the	DET
cet-12770	161	17	decrease	decrease	NOUN
cet-12770	161	18	of	of	ADP
cet-12770	161	19	clinic	clinic	NOUN
cet-12770	161	20	effectiveness	effectiveness	NOUN
cet-12770	161	21	due	due	ADP
cet-12770	161	22	to	to	ADP
cet-12770	161	23	drug	drug	NOUN
cet-12770	161	24	-	-	PUNCT
cet-12770	161	25	resistance	resistance	NOUN
cet-12770	161	26	,	,	PUNCT
cet-12770	161	27	therefore	therefore	ADV
cet-12770	161	28	keeping	keep	VERB
cet-12770	161	29	relatively	relatively	ADV
cet-12770	161	30	low	low	ADJ
cet-12770	161	31	dosage	dosage	NOUN
cet-12770	161	32	and	and	CCONJ
cet-12770	161	33	control	control	VERB
cet-12770	161	34	potential	potential	ADJ
cet-12770	161	35	side	side	NOUN
cet-12770	161	36	effect	effect	NOUN
cet-12770	161	37	to	to	PART
cet-12770	161	38	patient	patient	VERB
cet-12770	161	39	.	.	PUNCT
cet-12770	162	1	less	less	ADJ
cet-12770	162	2	drug	drug	NOUN
cet-12770	162	3	demand	demand	NOUN
cet-12770	162	4	will	will	AUX
cet-12770	162	5	keep	keep	VERB
cet-12770	162	6	the	the	DET
cet-12770	162	7	capacity	capacity	NOUN
cet-12770	162	8	of	of	ADP
cet-12770	162	9	pharmaceutical	pharmaceutical	ADJ
cet-12770	162	10	production	production	NOUN
cet-12770	162	11	and	and	CCONJ
cet-12770	162	12	related	related	ADJ
cet-12770	162	13	emissions	emission	NOUN
cet-12770	162	14	.	.	PUNCT
cet-12770	163	1	it	it	PRON
cet-12770	163	2	is	be	AUX
cet-12770	163	3	also	also	ADV
cet-12770	163	4	a	a	DET
cet-12770	163	5	contribution	contribution	NOUN
cet-12770	163	6	to	to	ADP
cet-12770	163	7	sustainable	sustainable	ADJ
cet-12770	163	8	development	development	NOUN
cet-12770	163	9	of	of	ADP
cet-12770	163	10	our	our	PRON
cet-12770	163	11	society	society	NOUN
cet-12770	163	12	.	.	PUNCT
cet-12770	164	1	appendix	appendix	NOUN
cet-12770	164	2	during	during	ADP
cet-12770	164	3	the	the	DET
cet-12770	164	4	time	time	NOUN
cet-12770	164	5	when	when	SCONJ
cet-12770	164	6	𝑢𝑢	𝑢𝑢	PRON
cet-12770	164	7	is	be	AUX
cet-12770	164	8	steadily	steadily	ADV
cet-12770	164	9	inputting	inputte	VERB
cet-12770	164	10	𝜏𝜏	𝜏𝜏	NOUN
cet-12770	164	11	with	with	ADP
cet-12770	164	12	quantity	quantity	NOUN
cet-12770	164	13	𝑥𝑥	𝑥𝑥	ADP
cet-12770	164	14	,	,	PUNCT
cet-12770	164	15	𝐸𝐸	𝐸𝐸	PROPN
cet-12770	164	16	=	=	SYM
cet-12770	164	17	𝑒𝑒𝑘𝑘𝑑𝑑(−1	𝑒𝑒𝑘𝑘𝑑𝑑(−1	PRON
cet-12770	165	1	+	+	CCONJ
cet-12770	165	2	𝑘𝑘)((−1	𝑘𝑘)((−1	NOUN
cet-12770	165	3	+	+	CCONJ
cet-12770	165	4	𝑒𝑒𝑑𝑑)𝑥𝑥	𝑒𝑒𝑑𝑑)𝑥𝑥	PROPN
cet-12770	165	5	+	+	PUNCT
cet-12770	165	6	𝑐𝑐(0	𝑐𝑐(0	NOUN
cet-12770	165	7	)	)	PUNCT
cet-12770	165	8	)	)	PUNCT
cet-12770	165	9	(	(	PUNCT
cet-12770	165	10	−𝑥𝑥	−𝑥𝑥	VERB
cet-12770	165	11	+	+	CCONJ
cet-12770	165	12	𝑒𝑒𝑑𝑑(1	𝑒𝑒𝑑𝑑(1	ADJ
cet-12770	165	13	+	+	CCONJ
cet-12770	165	14	𝑥𝑥	𝑥𝑥	ADP
cet-12770	165	15	)	)	PUNCT
cet-12770	165	16	+	+	NOUN
cet-12770	166	1	𝑐𝑐(0))(𝑥𝑥	𝑐𝑐(0))(𝑥𝑥	NOUN
cet-12770	167	1	+	+	CCONJ
cet-12770	167	2	𝑒𝑒𝑘𝑘𝑑𝑑(−1	𝑒𝑒𝑘𝑘𝑑𝑑(−1	PRON
cet-12770	168	1	+	+	CCONJ
cet-12770	168	2	𝑘𝑘)(1	𝑘𝑘)(1	ADP
cet-12770	168	3	+	+	CCONJ
cet-12770	168	4	𝑥𝑥	𝑥𝑥	ADP
cet-12770	168	5	)	)	PUNCT
cet-12770	168	6	−	−	PROPN
cet-12770	168	7	𝑒𝑒(−1+𝑘𝑘)𝑑𝑑𝑘𝑘(𝑥𝑥	𝑒𝑒(−1+𝑘𝑘)𝑑𝑑𝑘𝑘(𝑥𝑥	PROPN
cet-12770	168	8	−	−	PROPN
cet-12770	168	9	𝑐𝑐(0	𝑐𝑐(0	PROPN
cet-12770	168	10	)	)	PUNCT
cet-12770	168	11	)	)	PUNCT
cet-12770	169	1	−	−	PROPN
cet-12770	169	2	𝑘𝑘𝑐𝑐(0	𝑘𝑘𝑐𝑐(0	PROPN
cet-12770	169	3	)	)	PUNCT
cet-12770	169	4	)	)	PUNCT
cet-12770	169	5	(	(	PUNCT
cet-12770	169	6	23	23	NUM
cet-12770	169	7	)	)	PUNCT
cet-12770	169	8	𝑑𝑑𝐸𝐸	𝑑𝑑𝐸𝐸	ADP
cet-12770	169	9	𝑑𝑑𝑑𝑑	𝑑𝑑𝑑𝑑	NOUN
cet-12770	169	10	=	=	PUNCT
cet-12770	169	11	𝑒𝑒𝑘𝑘𝑑𝑑(−1	𝑒𝑒𝑘𝑘𝑑𝑑(−1	PRON
cet-12770	170	1	+	+	CCONJ
cet-12770	170	2	𝑘𝑘	𝑘𝑘	NOUN
cet-12770	170	3	)	)	PUNCT
cet-12770	170	4	𝐵𝐵(𝑑𝑑	𝐵𝐵(𝑑𝑑	PROPN
cet-12770	170	5	)	)	PUNCT
cet-12770	170	6	−	−	PROPN
cet-12770	170	7	𝐶𝐶(𝑑𝑑	𝐶𝐶(𝑑𝑑	PROPN
cet-12770	170	8	)	)	PUNCT
cet-12770	170	9	𝐴𝐴2	𝐴𝐴2	PROPN
cet-12770	170	10	(	(	PUNCT
cet-12770	170	11	24	24	NUM
cet-12770	170	12	)	)	PUNCT
cet-12770	170	13	where	where	SCONJ
cet-12770	170	14	𝐴𝐴	𝐴𝐴	PROPN
cet-12770	170	15	=	=	SYM
cet-12770	170	16	(	(	PUNCT
cet-12770	170	17	−𝑥𝑥	−𝑥𝑥	X
cet-12770	170	18	+	+	CCONJ
cet-12770	170	19	𝑒𝑒𝑑𝑑(1	𝑒𝑒𝑑𝑑(1	ADJ
cet-12770	170	20	+	+	CCONJ
cet-12770	170	21	𝑥𝑥	𝑥𝑥	ADP
cet-12770	170	22	)	)	PUNCT
cet-12770	170	23	+	+	NOUN
cet-12770	170	24	𝑐𝑐(0))2(𝑥𝑥	𝑐𝑐(0))2(𝑥𝑥	PROPN
cet-12770	171	1	+	+	X
cet-12770	171	2	𝑒𝑒𝑘𝑘𝑑𝑑(−1	𝑒𝑒𝑘𝑘𝑑𝑑(−1	PRON
cet-12770	172	1	+	+	CCONJ
cet-12770	172	2	𝑘𝑘)(1	𝑘𝑘)(1	ADP
cet-12770	172	3	+	+	CCONJ
cet-12770	172	4	𝑥𝑥	𝑥𝑥	ADP
cet-12770	172	5	)	)	PUNCT
cet-12770	172	6	−	−	PROPN
cet-12770	172	7	𝑒𝑒(−1+𝑘𝑘)𝑑𝑑𝑘𝑘(𝑥𝑥	𝑒𝑒(−1+𝑘𝑘)𝑑𝑑𝑘𝑘(𝑥𝑥	PROPN
cet-12770	172	8	−	−	PROPN
cet-12770	172	9	𝑐𝑐(0	𝑐𝑐(0	PROPN
cet-12770	172	10	)	)	PUNCT
cet-12770	172	11	)	)	PUNCT
cet-12770	173	1	−	−	PROPN
cet-12770	174	1	𝑘𝑘𝑐𝑐(0))2	𝑘𝑘𝑐𝑐(0))2	NUM
cet-12770	174	2	𝐵𝐵(𝑑𝑑	𝐵𝐵(𝑑𝑑	PROPN
cet-12770	174	3	)	)	PUNCT
cet-12770	174	4	=	=	SYM
cet-12770	174	5	2𝑒𝑒𝑘𝑘𝑑𝑑𝑘𝑘𝑥𝑥(𝑥𝑥	2𝑒𝑒𝑘𝑘𝑑𝑑𝑘𝑘𝑥𝑥(𝑥𝑥	NUM
cet-12770	174	6	−	−	NOUN
cet-12770	174	7	𝑐𝑐(0))2	𝑐𝑐(0))2	NOUN
cet-12770	174	8	+	+	CCONJ
cet-12770	174	9	𝑘𝑘(𝑥𝑥	𝑘𝑘(𝑥𝑥	PROPN
cet-12770	174	10	−	−	PROPN
cet-12770	174	11	𝑐𝑐(0))2(𝑥𝑥	𝑐𝑐(0))2(𝑥𝑥	PRON
cet-12770	174	12	−	−	NOUN
cet-12770	175	1	𝑘𝑘𝑐𝑐(0	𝑘𝑘𝑐𝑐(0	PROPN
cet-12770	175	2	)	)	PUNCT
cet-12770	175	3	)	)	PUNCT
cet-12770	176	1	+	+	CCONJ
cet-12770	176	2	𝑒𝑒2𝑑𝑑𝑘𝑘𝑥𝑥(1	𝑒𝑒2𝑑𝑑𝑘𝑘𝑥𝑥(1	NUM
cet-12770	176	3	+	+	NUM
cet-12770	176	4	𝑥𝑥)(𝑥𝑥	𝑥𝑥)(𝑥𝑥	NUM
cet-12770	176	5	−	−	NOUN
cet-12770	176	6	𝑘𝑘𝑐𝑐(0	𝑘𝑘𝑐𝑐(0	PROPN
cet-12770	176	7	)	)	PUNCT
cet-12770	176	8	)	)	PUNCT
cet-12770	177	1	+	+	CCONJ
cet-12770	177	2	𝑒𝑒𝑑𝑑(1	𝑒𝑒𝑑𝑑(1	ADJ
cet-12770	177	3	−	−	NOUN
cet-12770	177	4	𝑘𝑘	𝑘𝑘	NOUN
cet-12770	177	5	−	−	PROPN
cet-12770	177	6	2𝑘𝑘𝑥𝑥)(𝑥𝑥	2𝑘𝑘𝑥𝑥)(𝑥𝑥	NUM
cet-12770	177	7	−	−	PROPN
cet-12770	178	1	𝑐𝑐(0))(𝑥𝑥	𝑐𝑐(0))(𝑥𝑥	NOUN
cet-12770	178	2	−	−	PROPN
cet-12770	178	3	𝑘𝑘𝑐𝑐(0	𝑘𝑘𝑐𝑐(0	PROPN
cet-12770	178	4	)	)	PUNCT
cet-12770	178	5	)	)	PUNCT
cet-12770	178	6	𝐶𝐶(𝑑𝑑	𝐶𝐶(𝑑𝑑	NOUN
cet-12770	178	7	)	)	PUNCT
cet-12770	178	8	=	=	PUNCT
cet-12770	179	1	𝑒𝑒𝑑𝑑+𝑘𝑘𝑑𝑑(1	𝑒𝑒𝑑𝑑+𝑘𝑘𝑑𝑑(1	X
cet-12770	180	1	+	+	X
cet-12770	180	2	𝑘𝑘(−1	𝑘𝑘(−1	NOUN
cet-12770	181	1	+	+	CCONJ
cet-12770	181	2	𝑥𝑥))(1	𝑥𝑥))(1	X
cet-12770	181	3	+	+	CCONJ
cet-12770	181	4	𝑥𝑥)(𝑥𝑥	𝑥𝑥)(𝑥𝑥	PUNCT
cet-12770	181	5	−	−	PROPN
cet-12770	181	6	𝑐𝑐(0	𝑐𝑐(0	NOUN
cet-12770	181	7	)	)	PUNCT
cet-12770	181	8	)	)	PUNCT
cet-12770	182	1	+	+	CCONJ
cet-12770	182	2	𝑒𝑒(−1+𝑘𝑘)𝑑𝑑𝑘𝑘(𝑥𝑥	𝑒𝑒(−1+𝑘𝑘)𝑑𝑑𝑘𝑘(𝑥𝑥	PROPN
cet-12770	182	3	−	−	PROPN
cet-12770	182	4	𝑐𝑐(0))3	𝑐𝑐(0))3	INTJ
cet-12770	182	5	(	(	PUNCT
cet-12770	182	6	25	25	NUM
cet-12770	182	7	)	)	PUNCT
cet-12770	182	8	it	it	PRON
cet-12770	182	9	can	can	AUX
cet-12770	182	10	be	be	AUX
cet-12770	182	11	seen	see	VERB
cet-12770	182	12	that	that	SCONJ
cet-12770	182	13	when	when	SCONJ
cet-12770	182	14	𝐵𝐵(𝑑𝑑	𝐵𝐵(𝑑𝑑	PROPN
cet-12770	182	15	)	)	PUNCT
cet-12770	182	16	>	>	X
cet-12770	182	17	𝐶𝐶(𝑑𝑑	𝐶𝐶(𝑑𝑑	PROPN
cet-12770	182	18	)	)	PUNCT
cet-12770	182	19	,	,	PUNCT
cet-12770	182	20	e	e	PROPN
cet-12770	182	21	is	be	AUX
cet-12770	182	22	a	a	DET
cet-12770	182	23	monotonically	monotonically	ADV
cet-12770	182	24	increasing	increase	VERB
cet-12770	182	25	function	function	NOUN
cet-12770	182	26	.	.	PUNCT
cet-12770	183	1	when	when	SCONJ
cet-12770	183	2	𝐴𝐴	𝐴𝐴	PROPN
cet-12770	183	3	≠	≠	PROPN
cet-12770	183	4	0	0	NUM
cet-12770	183	5	and	and	CCONJ
cet-12770	183	6	𝐵𝐵(𝑑𝑑	𝐵𝐵(𝑑𝑑	PROPN
cet-12770	183	7	)	)	PUNCT
cet-12770	183	8	=	=	SYM
cet-12770	183	9	𝐶𝐶(𝑑𝑑	𝐶𝐶(𝑑𝑑	NOUN
cet-12770	183	10	)	)	PUNCT
cet-12770	183	11	,	,	PUNCT
cet-12770	183	12	𝐸𝐸	𝐸𝐸	PROPN
cet-12770	183	13	takes	take	VERB
cet-12770	183	14	the	the	DET
cet-12770	183	15	most	most	ADV
cet-12770	183	16	extreme	extreme	ADJ
cet-12770	183	17	value	value	NOUN
cet-12770	183	18	.	.	PUNCT
cet-12770	184	1	the	the	DET
cet-12770	184	2	problem	problem	NOUN
cet-12770	184	3	becomes	become	VERB
cet-12770	184	4	a	a	DET
cet-12770	184	5	problem	problem	NOUN
cet-12770	184	6	analyzing	analyze	VERB
cet-12770	184	7	𝐵𝐵(𝑑𝑑	𝐵𝐵(𝑑𝑑	PROPN
cet-12770	184	8	)	)	PUNCT
cet-12770	184	9	and	and	CCONJ
cet-12770	184	10	𝐶𝐶(𝑑𝑑	𝐶𝐶(𝑑𝑑	NOUN
cet-12770	184	11	)	)	PUNCT
cet-12770	184	12	.	.	PUNCT
cet-12770	185	1	as	as	SCONJ
cet-12770	185	2	shown	show	VERB
cet-12770	185	3	in	in	ADP
cet-12770	185	4	figure	figure	NOUN
cet-12770	185	5	6	6	NUM
cet-12770	185	6	,	,	PUNCT
cet-12770	185	7	when	when	SCONJ
cet-12770	185	8	𝑥𝑥	𝑥𝑥	ADP
cet-12770	185	9	∈	∈	PRON
cet-12770	185	10	[	[	X
cet-12770	185	11	1,2	1,2	NUM
cet-12770	185	12	]	]	PUNCT
cet-12770	185	13	,	,	PUNCT
cet-12770	185	14	𝑐𝑐(0	𝑐𝑐(0	NOUN
cet-12770	185	15	)	)	PUNCT
cet-12770	185	16	∈	∈	NOUN
cet-12770	186	1	[	[	X
cet-12770	186	2	0,1	0,1	NUM
cet-12770	186	3	]	]	PUNCT
cet-12770	186	4	,	,	PUNCT
cet-12770	186	5	𝐵𝐵(𝑑𝑑	𝐵𝐵(𝑑𝑑	PROPN
cet-12770	186	6	)	)	PUNCT
cet-12770	186	7	and	and	CCONJ
cet-12770	186	8	𝐶𝐶(𝑑𝑑	𝐶𝐶(𝑑𝑑	NOUN
cet-12770	186	9	)	)	PUNCT
cet-12770	186	10	is	be	AUX
cet-12770	186	11	a	a	DET
cet-12770	186	12	monotonically	monotonically	ADV
cet-12770	186	13	increasing	increase	VERB
cet-12770	186	14	function	function	NOUN
cet-12770	186	15	and	and	CCONJ
cet-12770	186	16	e	e	NOUN
cet-12770	186	17	has	have	VERB
cet-12770	186	18	one	one	NUM
cet-12770	186	19	and	and	CCONJ
cet-12770	186	20	only	only	ADV
cet-12770	186	21	one	one	NUM
cet-12770	186	22	extreme	extreme	ADJ
cet-12770	186	23	point	point	NOUN
cet-12770	186	24	.	.	PUNCT
cet-12770	187	1	a	a	DET
cet-12770	187	2	b	b	NOUN
cet-12770	187	3	c	c	NOUN
cet-12770	187	4	figure	figure	NOUN
cet-12770	187	5	6	6	NUM
cet-12770	187	6	:	:	PUNCT
cet-12770	187	7	schematic	schematic	ADJ
cet-12770	187	8	diagram	diagram	NOUN
cet-12770	187	9	of	of	ADP
cet-12770	187	10	the	the	DET
cet-12770	187	11	change	change	NOUN
cet-12770	187	12	of	of	ADP
cet-12770	187	13	𝐵𝐵(𝑑𝑑	𝐵𝐵(𝑑𝑑	PROPN
cet-12770	187	14	)	)	PUNCT
cet-12770	187	15	and	and	CCONJ
cet-12770	187	16	𝐶𝐶(𝑑𝑑	𝐶𝐶(𝑑𝑑	NOUN
cet-12770	187	17	)	)	PUNCT
cet-12770	187	18	with	with	ADP
cet-12770	187	19	time	time	NOUN
cet-12770	187	20	.	.	PUNCT
cet-12770	188	1	u=1	u=1	PROPN
cet-12770	188	2	,	,	PUNCT
cet-12770	188	3	𝑐𝑐(0	𝑐𝑐(0	PROPN
cet-12770	188	4	)	)	PUNCT
cet-12770	188	5	=	=	SYM
cet-12770	188	6	𝑎𝑎(0	𝑎𝑎(0	PROPN
cet-12770	188	7	)	)	PUNCT
cet-12770	188	8	=	=	SYM
cet-12770	188	9	0	0	NUM
cet-12770	188	10	to	to	PART
cet-12770	188	11	maximize	maximize	VERB
cet-12770	188	12	the	the	DET
cet-12770	188	13	optimization	optimization	NOUN
cet-12770	188	14	objective	objective	NOUN
cet-12770	188	15	∆𝑑𝑑	∆𝑑𝑑	PROPN
cet-12770	188	16	,	,	PUNCT
cet-12770	188	17	𝑚𝑚𝑎𝑎𝑥𝑥	𝑚𝑚𝑎𝑎𝑥𝑥	VERB
cet-12770	188	18	𝐸𝐸	𝐸𝐸	PROPN
cet-12770	188	19	must	must	AUX
cet-12770	188	20	be	be	AUX
cet-12770	188	21	greater	great	ADJ
cet-12770	188	22	than	than	ADP
cet-12770	188	23	0.3	0.3	NUM
cet-12770	188	24	.	.	PUNCT
cet-12770	189	1	this	this	PRON
cet-12770	189	2	means	mean	VERB
cet-12770	189	3	that	that	SCONJ
cet-12770	189	4	e(𝛽𝛽	e(𝛽𝛽	NUM
cet-12770	189	5	)	)	PUNCT
cet-12770	189	6	=	=	PUNCT
cet-12770	189	7	0.3	0.3	NUM
cet-12770	189	8	is	be	AUX
cet-12770	189	9	in	in	ADP
cet-12770	189	10	the	the	DET
cet-12770	189	11	monotonically	monotonically	ADV
cet-12770	189	12	decreasing	decrease	VERB
cet-12770	189	13	part	part	NOUN
cet-12770	189	14	.	.	PUNCT
cet-12770	190	1	the	the	DET
cet-12770	190	2	continued	continue	VERB
cet-12770	190	3	input	input	NOUN
cet-12770	190	4	of	of	ADP
cet-12770	190	5	𝑢𝑢	𝑢𝑢	PRON
cet-12770	190	6	will	will	AUX
cet-12770	190	7	decrease	decrease	VERB
cet-12770	190	8	drug	drug	NOUN
cet-12770	190	9	effect	effect	NOUN
cet-12770	190	10	due	due	ADP
cet-12770	190	11	to	to	ADP
cet-12770	190	12	the	the	DET
cet-12770	190	13	continuous	continuous	ADJ
cet-12770	190	14	increase	increase	NOUN
cet-12770	190	15	of	of	ADP
cet-12770	190	16	𝑎𝑎.	𝑎𝑎.	NOUN
cet-12770	190	17	it	it	PRON
cet-12770	190	18	is	be	AUX
cet-12770	190	19	better	well	ADJ
cet-12770	190	20	to	to	PART
cet-12770	190	21	stop	stop	VERB
cet-12770	190	22	the	the	DET
cet-12770	190	23	input	input	NOUN
cet-12770	190	24	and	and	CCONJ
cet-12770	190	25	let	let	VERB
cet-12770	190	26	𝑎𝑎	𝑎𝑎	NOUN
cet-12770	190	27	to	to	PART
cet-12770	190	28	recover	recover	VERB
cet-12770	190	29	.	.	PUNCT
cet-12770	191	1	acknowledgments	acknowledgment	NOUN
cet-12770	191	2	the	the	DET
cet-12770	191	3	national	national	ADJ
cet-12770	191	4	natural	natural	PROPN
cet-12770	191	5	science	science	PROPN
cet-12770	191	6	foundation	foundation	PROPN
cet-12770	191	7	of	of	ADP
cet-12770	191	8	china	china	PROPN
cet-12770	191	9	(	(	PUNCT
cet-12770	191	10	grant	grant	VERB
cet-12770	191	11	no	no	NOUN
cet-12770	191	12	.	.	NOUN
cet-12770	191	13	21878012	21878012	NUM
cet-12770	191	14	)	)	PUNCT
cet-12770	191	15	.	.	PUNCT
cet-12770	192	1	references	reference	NOUN
cet-12770	192	2	ghanaatpishe	ghanaatpishe	PROPN
cet-12770	192	3	m.	m.	PROPN
cet-12770	192	4	,	,	PUNCT
cet-12770	192	5	kehs	kehs	PROPN
cet-12770	192	6	m.a	m.a	PROPN
cet-12770	192	7	.	.	PROPN
cet-12770	192	8	,	,	PUNCT
cet-12770	192	9	fathy	fathy	PROPN
cet-12770	192	10	h.k	h.k	PROPN
cet-12770	192	11	.	.	PROPN
cet-12770	192	12	,	,	PUNCT
cet-12770	192	13	2017	2017	NUM
cet-12770	192	14	,	,	PUNCT
cet-12770	192	15	online	online	ADJ
cet-12770	192	16	shaping	shaping	NOUN
cet-12770	192	17	of	of	ADP
cet-12770	192	18	a	a	DET
cet-12770	192	19	drug	drug	NOUN
cet-12770	192	20	's	's	PART
cet-12770	192	21	periodic	periodic	ADJ
cet-12770	192	22	administration	administration	NOUN
cet-12770	192	23	trajectory	trajectory	NOUN
cet-12770	192	24	for	for	ADP
cet-12770	192	25	efficacy	efficacy	NOUN
cet-12770	192	26	maximization	maximization	NOUN
cet-12770	192	27	,	,	PUNCT
cet-12770	192	28	ieee	ieee	NOUN
cet-12770	192	29	transactions	transaction	NOUN
cet-12770	192	30	on	on	ADP
cet-12770	192	31	control	control	NOUN
cet-12770	192	32	systems	system	NOUN
cet-12770	192	33	technology	technology	NOUN
cet-12770	192	34	,	,	PUNCT
cet-12770	192	35	25(6),1989	25(6),1989	NUM
cet-12770	192	36	-	-	SYM
cet-12770	192	37	1999	1999	NUM
cet-12770	192	38	.	.	PUNCT
cet-12770	193	1	mclean	mclean	PROPN
cet-12770	193	2	k.	k.	PROPN
cet-12770	193	3	,	,	PUNCT
cet-12770	193	4	zhan	zhan	PROPN
cet-12770	193	5	w.	w.	PROPN
cet-12770	193	6	,	,	PUNCT
cet-12770	193	7	2021	2021	NUM
cet-12770	193	8	,	,	PUNCT
cet-12770	193	9	mathematical	mathematical	ADJ
cet-12770	193	10	modelling	modelling	NOUN
cet-12770	193	11	of	of	ADP
cet-12770	193	12	nanoparticle	nanoparticle	NOUN
cet-12770	193	13	-	-	PUNCT
cet-12770	193	14	mediated	mediate	VERB
cet-12770	193	15	topical	topical	ADJ
cet-12770	193	16	drug	drug	NOUN
cet-12770	193	17	delivery	delivery	NOUN
cet-12770	193	18	to	to	ADP
cet-12770	193	19	skin	skin	NOUN
cet-12770	193	20	tissue	tissue	NOUN
cet-12770	193	21	,	,	PUNCT
cet-12770	193	22	international	international	ADJ
cet-12770	193	23	journal	journal	NOUN
cet-12770	193	24	of	of	ADP
cet-12770	193	25	pharmaceutics	pharmaceutic	NOUN
cet-12770	193	26	,	,	PUNCT
cet-12770	193	27	611	611	NUM
cet-12770	193	28	,	,	PUNCT
cet-12770	193	29	121322	121322	NUM
cet-12770	193	30	parker	parker	PROPN
cet-12770	193	31	j.o	j.o	PROPN
cet-12770	193	32	.	.	PROPN
cet-12770	193	33	,	,	PUNCT
cet-12770	193	34	amies	amies	PROPN
cet-12770	193	35	m.h	m.h	PROPN
cet-12770	193	36	.	.	PROPN
cet-12770	193	37	,hawkinson	,hawkinson	PUNCT
cet-12770	193	38	r.w	r.w	PROPN
cet-12770	193	39	.	.	PROPN
cet-12770	193	40	,	,	PUNCT
cet-12770	193	41	heilman	heilman	PROPN
cet-12770	193	42	j.m	j.m	PROPN
cet-12770	193	43	.	.	PROPN
cet-12770	193	44	,	,	PUNCT
cet-12770	193	45	hougham	hougham	PROPN
cet-12770	193	46	a.j	a.j	PROPN
cet-12770	193	47	.	.	PROPN
cet-12770	193	48	,	,	PUNCT
cet-12770	193	49	vollmer	vollmer	PROPN
cet-12770	193	50	m.c	m.c	PROPN
cet-12770	193	51	.	.	PROPN
cet-12770	193	52	,	,	PUNCT
cet-12770	193	53	wilson	wilson	PROPN
cet-12770	193	54	r.r	r.r	PROPN
cet-12770	193	55	.	.	PROPN
cet-12770	193	56	,	,	PUNCT
cet-12770	193	57	1995	1995	NUM
cet-12770	193	58	,	,	PUNCT
cet-12770	193	59	intermittent	intermittent	ADJ
cet-12770	193	60	transdermal	transdermal	ADJ
cet-12770	193	61	nitroglycerin	nitroglycerin	NOUN
cet-12770	193	62	therapy	therapy	NOUN
cet-12770	193	63	in	in	ADP
cet-12770	193	64	angina	angina	PROPN
cet-12770	193	65	pectoris	pectoris	PROPN
cet-12770	193	66	,	,	PUNCT
cet-12770	193	67	clinically	clinically	ADV
cet-12770	193	68	effective	effective	ADJ
cet-12770	193	69	without	without	ADP
cet-12770	193	70	tolerance	tolerance	NOUN
cet-12770	193	71	or	or	CCONJ
cet-12770	193	72	rebound	rebound	NOUN
cet-12770	193	73	,	,	PUNCT
cet-12770	193	74	circulation	circulation	NOUN
cet-12770	193	75	,	,	PUNCT
cet-12770	193	76	91(5	91(5	NUM
cet-12770	193	77	)	)	PUNCT
cet-12770	193	78	,	,	PUNCT
cet-12770	193	79	1368	1368	NUM
cet-12770	193	80	-	-	SYM
cet-12770	193	81	1374	1374	NUM
cet-12770	193	82	porchet	porchet	NOUN
cet-12770	193	83	h.c	h.c	PROPN
cet-12770	193	84	.	.	PROPN
cet-12770	193	85	,	,	PUNCT
cet-12770	193	86	benowitz	benowitz	PROPN
cet-12770	193	87	n.l	n.l	PROPN
cet-12770	193	88	.	.	PROPN
cet-12770	193	89	,	,	PUNCT
cet-12770	193	90	sheiner	sheiner	NOUN
cet-12770	194	1	l.b	l.b	PROPN
cet-12770	194	2	.	.	PROPN
cet-12770	194	3	,	,	PUNCT
cet-12770	194	4	1988	1988	NUM
cet-12770	194	5	,	,	PUNCT
cet-12770	194	6	pharmacodynamic	pharmacodynamic	ADJ
cet-12770	194	7	model	model	NOUN
cet-12770	194	8	of	of	ADP
cet-12770	194	9	tolerance	tolerance	NOUN
cet-12770	194	10	:	:	PUNCT
cet-12770	194	11	application	application	NOUN
cet-12770	194	12	to	to	ADP
cet-12770	194	13	nicotine	nicotine	NOUN
cet-12770	194	14	,	,	PUNCT
cet-12770	194	15	journal	journal	NOUN
cet-12770	194	16	of	of	ADP
cet-12770	194	17	pharmacology	pharmacology	NOUN
cet-12770	194	18	and	and	CCONJ
cet-12770	194	19	experimental	experimental	ADJ
cet-12770	194	20	therapeutics	therapeutic	NOUN
cet-12770	194	21	,	,	PUNCT
cet-12770	194	22	244(1	244(1	NUM
cet-12770	194	23	)	)	PUNCT
cet-12770	194	24	,	,	PUNCT
cet-12770	194	25	231	231	NUM
cet-12770	194	26	-	-	SYM
cet-12770	194	27	236	236	NUM
cet-12770	194	28	.	.	PUNCT
cet-12770	195	1	varigonda	varigonda	PROPN
cet-12770	195	2	s.	s.	PROPN
cet-12770	195	3	,	,	PUNCT
cet-12770	195	4	georgiou	georgiou	PROPN
cet-12770	195	5	t.t	t.t	PROPN
cet-12770	195	6	.	.	PROPN
cet-12770	195	7	,	,	PUNCT
cet-12770	195	8	siegel	siegel	PROPN
cet-12770	195	9	r.a	r.a	PROPN
cet-12770	195	10	.	.	PROPN
cet-12770	195	11	,	,	PUNCT
cet-12770	195	12	daoutidis	daoutidis	PROPN
cet-12770	195	13	p.	p.	PROPN
cet-12770	195	14	,	,	PUNCT
cet-12770	195	15	2008	2008	NUM
cet-12770	195	16	,	,	PUNCT
cet-12770	195	17	optimal	optimal	ADJ
cet-12770	195	18	periodic	periodic	ADJ
cet-12770	195	19	control	control	NOUN
cet-12770	195	20	of	of	ADP
cet-12770	195	21	a	a	DET
cet-12770	195	22	drug	drug	NOUN
cet-12770	195	23	delivery	delivery	NOUN
cet-12770	195	24	system	system	NOUN
cet-12770	195	25	,	,	PUNCT
cet-12770	195	26	computers	computer	NOUN
cet-12770	195	27	&	&	CCONJ
cet-12770	195	28	chemical	chemical	PROPN
cet-12770	195	29	engineering	engineering	PROPN
cet-12770	195	30	,	,	PUNCT
cet-12770	195	31	32(10	32(10	NUM
cet-12770	195	32	)	)	PUNCT
cet-12770	195	33	,	,	PUNCT
cet-12770	195	34	2256	2256	NUM
cet-12770	195	35	-	-	SYM
cet-12770	195	36	2262	2262	NUM
cet-12770	195	37	.	.	PUNCT
cet-12770	196	1	1284	1284	NUM
cet-12770	196	2	pres22_0491.pdf	pres22_0491.pdf	NOUN
cet-12770	196	3	pulse	pulse	NOUN
cet-12770	196	4	drug	drug	NOUN
cet-12770	196	5	delivery	delivery	NOUN
cet-12770	196	6	strategy	strategy	NOUN
cet-12770	196	7	based	base	VERB
cet-12770	196	8	on	on	ADP
cet-12770	196	9	pharmacokinetic	pharmacokinetic	NOUN
cet-12770	196	10	-	-	PUNCT
cet-12770	196	11	pharmacodynamic	pharmacodynamic	ADJ
cet-12770	196	12	(	(	PUNCT
cet-12770	196	13	pk	pk	NOUN
cet-12770	196	14	-	-	PUNCT
cet-12770	196	15	pd	pd	NOUN
cet-12770	196	16	)	)	PUNCT
cet-12770	196	17	model	model	NOUN
cet-12770	196	18	of	of	ADP
cet-12770	196	19	tolerance	tolerance	NOUN