id	sid	tid	token	lemma	pos
cet-13158	1	1	cet	cet	PROPN
cet-13158	1	2	vol	vol	NOUN
cet-13158	1	3	99	99	NUM
cet-13158	1	4	doi	doi	NOUN
cet-13158	1	5	:	:	PUNCT
cet-13158	1	6	10.3303	10.3303	NUM
cet-13158	1	7	/	/	SYM
cet-13158	1	8	cet2399080	cet2399080	NOUN
cet-13158	1	9	paper	paper	NOUN
cet-13158	1	10	received	receive	VERB
cet-13158	1	11	:	:	PUNCT
cet-13158	1	12	30	30	NUM
cet-13158	1	13	november	november	NOUN
cet-13158	1	14	2022	2022	NUM
cet-13158	1	15	;	;	PUNCT
cet-13158	1	16	revised	revise	VERB
cet-13158	1	17	:	:	PUNCT
cet-13158	1	18	9	9	NUM
cet-13158	1	19	march	march	NOUN
cet-13158	1	20	2023	2023	NUM
cet-13158	1	21	;	;	PUNCT
cet-13158	1	22	accepted	accept	VERB
cet-13158	1	23	:	:	PUNCT
cet-13158	1	24	29	29	NUM
cet-13158	1	25	april	april	PROPN
cet-13158	1	26	2023	2023	NUM
cet-13158	1	27	please	please	INTJ
cet-13158	1	28	cite	cite	VERB
cet-13158	1	29	this	this	DET
cet-13158	1	30	article	article	NOUN
cet-13158	1	31	as	as	ADP
cet-13158	1	32	:	:	PUNCT
cet-13158	1	33	schaare	schaare	PROPN
cet-13158	1	34	l.	l.	PROPN
cet-13158	1	35	,	,	PUNCT
cet-13158	1	36	kuwertz	kuwertz	PROPN
cet-13158	1	37	r.	r.	PROPN
cet-13158	1	38	,	,	PUNCT
cet-13158	1	39	heck	heck	INTJ
cet-13158	1	40	j.	j.	PROPN
cet-13158	1	41	,	,	PUNCT
cet-13158	1	42	skiborowski	skiborowski	PROPN
cet-13158	1	43	m.	m.	NOUN
cet-13158	1	44	,	,	PUNCT
cet-13158	1	45	2023	2023	NUM
cet-13158	1	46	,	,	PUNCT
cet-13158	1	47	intensification	intensification	NOUN
cet-13158	1	48	of	of	ADP
cet-13158	1	49	kinetic	kinetic	ADJ
cet-13158	1	50	studies	study	NOUN
cet-13158	1	51	for	for	ADP
cet-13158	1	52	a	a	DET
cet-13158	1	53	multi	multi	ADJ
cet-13158	1	54	-	-	ADJ
cet-13158	1	55	step	step	ADJ
cet-13158	1	56	reaction	reaction	NOUN
cet-13158	1	57	in	in	ADP
cet-13158	1	58	a	a	DET
cet-13158	1	59	milli	milli	ADJ
cet-13158	1	60	-	-	PUNCT
cet-13158	1	61	structured	structured	ADJ
cet-13158	1	62	plate	plate	NOUN
cet-13158	1	63	reactor	reactor	NOUN
cet-13158	1	64	by	by	ADP
cet-13158	1	65	using	use	VERB
cet-13158	1	66	model	model	NOUN
cet-13158	1	67	-	-	PUNCT
cet-13158	1	68	based	base	VERB
cet-13158	1	69	design	design	NOUN
cet-13158	1	70	of	of	ADP
cet-13158	1	71	experiments	experiment	NOUN
cet-13158	1	72	,	,	PUNCT
cet-13158	1	73	chemical	chemical	ADJ
cet-13158	1	74	engineering	engineering	NOUN
cet-13158	1	75	transactions	transaction	NOUN
cet-13158	1	76	,	,	PUNCT
cet-13158	1	77	99	99	NUM
cet-13158	1	78	,	,	PUNCT
cet-13158	1	79	475	475	NUM
cet-13158	1	80	-	-	SYM
cet-13158	1	81	480	480	NUM
cet-13158	1	82	doi:10.3303	doi:10.3303	NOUN
cet-13158	1	83	/	/	SYM
cet-13158	1	84	cet2399080	cet2399080	NOUN
cet-13158	1	85	chemical	chemical	PROPN
cet-13158	1	86	engineering	engineering	NOUN
cet-13158	1	87	transactions	transaction	NOUN
cet-13158	1	88	vol	vol	NOUN
cet-13158	1	89	.	.	PROPN
cet-13158	1	90	99	99	NUM
cet-13158	1	91	,	,	PUNCT
cet-13158	1	92	2023	2023	NUM
cet-13158	1	93	a	a	DET
cet-13158	1	94	publication	publication	NOUN
cet-13158	1	95	of	of	ADP
cet-13158	1	96	the	the	DET
cet-13158	1	97	italian	italian	ADJ
cet-13158	1	98	association	association	NOUN
cet-13158	1	99	of	of	ADP
cet-13158	1	100	chemical	chemical	PROPN
cet-13158	1	101	engineering	engineering	NOUN
cet-13158	1	102	online	online	ADV
cet-13158	1	103	at	at	ADP
cet-13158	1	104	www.cetjournal.it	www.cetjournal.it	PROPN
cet-13158	1	105	guest	guest	NOUN
cet-13158	1	106	editors	editor	NOUN
cet-13158	1	107	:	:	PUNCT
cet-13158	1	108	sauro	sauro	PROPN
cet-13158	1	109	pierucci	pierucci	PROPN
cet-13158	1	110	,	,	PUNCT
cet-13158	1	111	flavio	flavio	PROPN
cet-13158	1	112	manenti	manenti	VERB
cet-13158	1	113	copyright	copyright	NOUN
cet-13158	1	114	©	©	PROPN
cet-13158	1	115	2023	2023	NUM
cet-13158	1	116	,	,	PUNCT
cet-13158	1	117	aidic	aidic	ADJ
cet-13158	1	118	servizi	servizi	PROPN
cet-13158	1	119	s.r.l	s.r.l	PROPN
cet-13158	1	120	.	.	PUNCT
cet-13158	2	1	isbn	isbn	ADJ
cet-13158	2	2	978	978	NUM
cet-13158	2	3	-	-	SYM
cet-13158	2	4	88	88	NUM
cet-13158	2	5	-	-	PUNCT
cet-13158	2	6	95608	95608	NUM
cet-13158	2	7	-	-	PUNCT
cet-13158	2	8	98	98	NUM
cet-13158	2	9	-	-	SYM
cet-13158	2	10	3	3	NUM
cet-13158	2	11	;	;	PUNCT
cet-13158	2	12	issn	issn	PROPN
cet-13158	2	13	2283	2283	NUM
cet-13158	2	14	-	-	SYM
cet-13158	2	15	9216	9216	NUM
cet-13158	2	16	intensification	intensification	NOUN
cet-13158	2	17	of	of	ADP
cet-13158	2	18	kinetic	kinetic	ADJ
cet-13158	2	19	studies	study	NOUN
cet-13158	2	20	for	for	ADP
cet-13158	2	21	a	a	DET
cet-13158	2	22	multi	multi	ADJ
cet-13158	2	23	-	-	ADJ
cet-13158	2	24	step	step	ADJ
cet-13158	2	25	reaction	reaction	NOUN
cet-13158	2	26	in	in	ADP
cet-13158	2	27	a	a	DET
cet-13158	2	28	milli	milli	ADJ
cet-13158	2	29	-	-	PUNCT
cet-13158	2	30	structured	structured	ADJ
cet-13158	2	31	plate	plate	NOUN
cet-13158	2	32	reactor	reactor	NOUN
cet-13158	2	33	by	by	ADP
cet-13158	2	34	using	use	VERB
cet-13158	2	35	model	model	NOUN
cet-13158	2	36	-	-	PUNCT
cet-13158	2	37	based	base	VERB
cet-13158	2	38	design	design	NOUN
cet-13158	2	39	of	of	ADP
cet-13158	2	40	experiments	experiment	NOUN
cet-13158	2	41	lucas	lucas	PROPN
cet-13158	2	42	schaareab	schaareab	PROPN
cet-13158	2	43	*	*	PROPN
cet-13158	2	44	,	,	PUNCT
cet-13158	2	45	rafael	rafael	PROPN
cet-13158	2	46	kuwertzb	kuwertzb	PROPN
cet-13158	2	47	,	,	PUNCT
cet-13158	2	48	joachim	joachim	PROPN
cet-13158	2	49	heckb	heckb	PROPN
cet-13158	2	50	,	,	PUNCT
cet-13158	2	51	mirko	mirko	PROPN
cet-13158	2	52	skiborowskia	skiborowskia	PROPN
cet-13158	2	53	ahamburg	ahamburg	PROPN
cet-13158	2	54	university	university	PROPN
cet-13158	2	55	of	of	ADP
cet-13158	2	56	technology	technology	PROPN
cet-13158	2	57	,	,	PUNCT
cet-13158	2	58	institute	institute	NOUN
cet-13158	2	59	of	of	ADP
cet-13158	2	60	process	process	NOUN
cet-13158	2	61	systems	system	NOUN
cet-13158	2	62	engineering	engineering	NOUN
cet-13158	2	63	,	,	PUNCT
cet-13158	2	64	am	be	AUX
cet-13158	2	65	schwarzenberg	schwarzenberg	NOUN
cet-13158	2	66	-	-	PUNCT
cet-13158	2	67	campus	campus	NOUN
cet-13158	2	68	4	4	NUM
cet-13158	2	69	,	,	PUNCT
cet-13158	2	70	21073	21073	NUM
cet-13158	2	71	hamburg	hamburg	PROPN
cet-13158	2	72	,	,	PUNCT
cet-13158	2	73	germany	germany	PROPN
cet-13158	2	74	behrfeld	behrfeld	VERB
cet-13158	2	75	mikrotechnik	mikrotechnik	PROPN
cet-13158	2	76	gmbh	gmbh	PROPN
cet-13158	2	77	,	,	PUNCT
cet-13158	2	78	mikro	mikro	PROPN
cet-13158	2	79	-	-	PUNCT
cet-13158	2	80	forum	forum	PROPN
cet-13158	2	81	-	-	PUNCT
cet-13158	2	82	ring	ring	NOUN
cet-13158	2	83	1	1	NUM
cet-13158	2	84	,	,	PUNCT
cet-13158	2	85	55234	55234	NUM
cet-13158	2	86	wendelsheim	wendelsheim	NOUN
cet-13158	2	87	,	,	PUNCT
cet-13158	2	88	germany	germany	PROPN
cet-13158	2	89	lucas.schaare@tuhh.de	lucas.schaare@tuhh.de	PROPN
cet-13158	2	90	in	in	ADP
cet-13158	2	91	the	the	DET
cet-13158	2	92	context	context	NOUN
cet-13158	2	93	of	of	ADP
cet-13158	2	94	process	process	NOUN
cet-13158	2	95	intensification	intensification	NOUN
cet-13158	2	96	,	,	PUNCT
cet-13158	2	97	milli	milli	ADJ
cet-13158	2	98	-	-	PUNCT
cet-13158	2	99	structured	structured	ADJ
cet-13158	2	100	plate	plate	NOUN
cet-13158	2	101	reactors	reactor	NOUN
cet-13158	2	102	provide	provide	VERB
cet-13158	2	103	significant	significant	ADJ
cet-13158	2	104	advantages	advantage	NOUN
cet-13158	2	105	over	over	ADP
cet-13158	2	106	conventional	conventional	ADJ
cet-13158	2	107	reactors	reactor	NOUN
cet-13158	2	108	in	in	ADP
cet-13158	2	109	terms	term	NOUN
cet-13158	2	110	of	of	ADP
cet-13158	2	111	heat	heat	NOUN
cet-13158	2	112	and	and	CCONJ
cet-13158	2	113	mass	mass	NOUN
cet-13158	2	114	transfer	transfer	NOUN
cet-13158	2	115	as	as	ADV
cet-13158	2	116	well	well	ADV
cet-13158	2	117	as	as	ADP
cet-13158	2	118	process	process	NOUN
cet-13158	2	119	safety	safety	NOUN
cet-13158	2	120	.	.	PUNCT
cet-13158	3	1	the	the	DET
cet-13158	3	2	art	art	NOUN
cet-13158	3	3	®	®	NOUN
cet-13158	3	4	plate	plate	NOUN
cet-13158	3	5	reactor	reactor	NOUN
cet-13158	3	6	pr37	pr37	PROPN
cet-13158	3	7	of	of	ADP
cet-13158	3	8	ehrfeld	ehrfeld	VERB
cet-13158	3	9	mikrotechnik	mikrotechnik	PROPN
cet-13158	3	10	gmbh	gmbh	PROPN
cet-13158	3	11	offers	offer	VERB
cet-13158	3	12	excellent	excellent	ADJ
cet-13158	3	13	heat	heat	NOUN
cet-13158	3	14	transfer	transfer	NOUN
cet-13158	3	15	,	,	PUNCT
cet-13158	3	16	narrow	narrow	ADJ
cet-13158	3	17	residence	residence	NOUN
cet-13158	3	18	time	time	NOUN
cet-13158	3	19	distributions	distribution	NOUN
cet-13158	3	20	and	and	CCONJ
cet-13158	3	21	high	high	ADJ
cet-13158	3	22	mixing	mixing	NOUN
cet-13158	3	23	efficiency	efficiency	NOUN
cet-13158	3	24	,	,	PUNCT
cet-13158	3	25	while	while	SCONJ
cet-13158	3	26	simultaneously	simultaneously	ADV
cet-13158	3	27	allowing	allow	VERB
cet-13158	3	28	an	an	DET
cet-13158	3	29	effective	effective	ADJ
cet-13158	3	30	scale	scale	NOUN
cet-13158	3	31	-	-	PUNCT
cet-13158	3	32	up	up	NOUN
cet-13158	3	33	to	to	ADP
cet-13158	3	34	industrial	industrial	ADJ
cet-13158	3	35	applications	application	NOUN
cet-13158	3	36	due	due	ADP
cet-13158	3	37	to	to	ADP
cet-13158	3	38	its	its	PRON
cet-13158	3	39	modular	modular	NOUN
cet-13158	3	40	set	set	VERB
cet-13158	3	41	up	up	ADP
cet-13158	3	42	.	.	PUNCT
cet-13158	4	1	this	this	PRON
cet-13158	4	2	does	do	AUX
cet-13158	4	3	not	not	PART
cet-13158	4	4	only	only	ADV
cet-13158	4	5	enable	enable	VERB
cet-13158	4	6	the	the	DET
cet-13158	4	7	realization	realization	NOUN
cet-13158	4	8	of	of	ADP
cet-13158	4	9	novel	novel	ADJ
cet-13158	4	10	process	process	NOUN
cet-13158	4	11	windows	window	NOUN
cet-13158	4	12	exceeding	exceed	VERB
cet-13158	4	13	the	the	DET
cet-13158	4	14	limits	limit	NOUN
cet-13158	4	15	of	of	ADP
cet-13158	4	16	conventional	conventional	ADJ
cet-13158	4	17	reactors	reactor	NOUN
cet-13158	4	18	,	,	PUNCT
cet-13158	4	19	but	but	CCONJ
cet-13158	4	20	also	also	ADV
cet-13158	4	21	provides	provide	VERB
cet-13158	4	22	optimal	optimal	ADJ
cet-13158	4	23	prerequisites	prerequisite	NOUN
cet-13158	4	24	for	for	ADP
cet-13158	4	25	kinetic	kinetic	ADJ
cet-13158	4	26	modelling	modelling	NOUN
cet-13158	4	27	due	due	ADP
cet-13158	4	28	to	to	ADP
cet-13158	4	29	the	the	DET
cet-13158	4	30	well	well	ADV
cet-13158	4	31	-	-	PUNCT
cet-13158	4	32	defined	define	VERB
cet-13158	4	33	process	process	NOUN
cet-13158	4	34	conditions	condition	NOUN
cet-13158	4	35	,	,	PUNCT
cet-13158	4	36	providing	provide	VERB
cet-13158	4	37	key	key	ADJ
cet-13158	4	38	information	information	NOUN
cet-13158	4	39	regarding	regard	VERB
cet-13158	4	40	process	process	NOUN
cet-13158	4	41	design	design	NOUN
cet-13158	4	42	and	and	CCONJ
cet-13158	4	43	optimization	optimization	NOUN
cet-13158	4	44	.	.	PUNCT
cet-13158	5	1	the	the	DET
cet-13158	5	2	integration	integration	NOUN
cet-13158	5	3	of	of	ADP
cet-13158	5	4	the	the	DET
cet-13158	5	5	art	art	NOUN
cet-13158	5	6	pr37	pr37	PROPN
cet-13158	5	7	with	with	ADP
cet-13158	5	8	model	model	NOUN
cet-13158	5	9	-	-	PUNCT
cet-13158	5	10	based	base	VERB
cet-13158	5	11	design	design	NOUN
cet-13158	5	12	of	of	ADP
cet-13158	5	13	experiments	experiment	NOUN
cet-13158	5	14	(	(	PUNCT
cet-13158	5	15	mbdoe	mbdoe	NOUN
cet-13158	5	16	)	)	PUNCT
cet-13158	5	17	allows	allow	VERB
cet-13158	5	18	for	for	ADP
cet-13158	5	19	an	an	DET
cet-13158	5	20	intensification	intensification	NOUN
cet-13158	5	21	of	of	ADP
cet-13158	5	22	kinetic	kinetic	ADJ
cet-13158	5	23	studies	study	NOUN
cet-13158	5	24	,	,	PUNCT
cet-13158	5	25	combining	combine	VERB
cet-13158	5	26	the	the	DET
cet-13158	5	27	well	well	ADV
cet-13158	5	28	-	-	PUNCT
cet-13158	5	29	defined	define	VERB
cet-13158	5	30	operating	operating	NOUN
cet-13158	5	31	conditions	condition	NOUN
cet-13158	5	32	with	with	ADP
cet-13158	5	33	a	a	DET
cet-13158	5	34	rapid	rapid	ADJ
cet-13158	5	35	and	and	CCONJ
cet-13158	5	36	targeted	target	VERB
cet-13158	5	37	identification	identification	NOUN
cet-13158	5	38	of	of	ADP
cet-13158	5	39	kinetic	kinetic	ADJ
cet-13158	5	40	models	model	NOUN
cet-13158	5	41	.	.	PUNCT
cet-13158	6	1	in	in	ADP
cet-13158	6	2	the	the	DET
cet-13158	6	3	current	current	ADJ
cet-13158	6	4	study	study	NOUN
cet-13158	6	5	this	this	DET
cet-13158	6	6	combination	combination	NOUN
cet-13158	6	7	is	be	AUX
cet-13158	6	8	applied	apply	VERB
cet-13158	6	9	to	to	PART
cet-13158	6	10	successfully	successfully	ADV
cet-13158	6	11	identify	identify	VERB
cet-13158	6	12	the	the	DET
cet-13158	6	13	kinetics	kinetic	NOUN
cet-13158	6	14	of	of	ADP
cet-13158	6	15	a	a	DET
cet-13158	6	16	multistep	multistep	ADJ
cet-13158	6	17	aromatic	aromatic	ADJ
cet-13158	6	18	nucleophilic	nucleophilic	ADJ
cet-13158	6	19	substitution	substitution	NOUN
cet-13158	6	20	reaction	reaction	NOUN
cet-13158	6	21	with	with	ADP
cet-13158	6	22	low	low	ADJ
cet-13158	6	23	experimental	experimental	ADJ
cet-13158	6	24	effort	effort	NOUN
cet-13158	6	25	,	,	PUNCT
cet-13158	6	26	saving	save	VERB
cet-13158	6	27	time	time	NOUN
cet-13158	6	28	and	and	CCONJ
cet-13158	6	29	resources	resource	NOUN
cet-13158	6	30	compared	compare	VERB
cet-13158	6	31	to	to	ADP
cet-13158	6	32	conventional	conventional	ADJ
cet-13158	6	33	factorial	factorial	ADJ
cet-13158	6	34	design	design	NOUN
cet-13158	6	35	of	of	ADP
cet-13158	6	36	experiments	experiment	NOUN
cet-13158	6	37	.	.	PUNCT
cet-13158	7	1	1	1	X
cet-13158	7	2	.	.	X
cet-13158	7	3	introduction	introduction	NOUN
cet-13158	7	4	the	the	DET
cet-13158	7	5	optimal	optimal	ADJ
cet-13158	7	6	design	design	NOUN
cet-13158	7	7	of	of	ADP
cet-13158	7	8	experiments	experiment	NOUN
cet-13158	7	9	(	(	PUNCT
cet-13158	7	10	doe	doe	NOUN
cet-13158	7	11	)	)	PUNCT
cet-13158	7	12	is	be	AUX
cet-13158	7	13	a	a	DET
cet-13158	7	14	non	non	ADJ
cet-13158	7	15	-	-	ADJ
cet-13158	7	16	trivial	trivial	ADJ
cet-13158	7	17	task	task	NOUN
cet-13158	7	18	,	,	PUNCT
cet-13158	7	19	especially	especially	ADV
cet-13158	7	20	for	for	ADP
cet-13158	7	21	complex	complex	ADJ
cet-13158	7	22	systems	system	NOUN
cet-13158	7	23	with	with	ADP
cet-13158	7	24	nonlinear	nonlinear	ADJ
cet-13158	7	25	dynamics	dynamic	NOUN
cet-13158	7	26	.	.	PUNCT
cet-13158	8	1	poorly	poorly	ADV
cet-13158	8	2	designed	design	VERB
cet-13158	8	3	experiments	experiment	NOUN
cet-13158	8	4	may	may	AUX
cet-13158	8	5	yield	yield	VERB
cet-13158	8	6	inadequate	inadequate	ADJ
cet-13158	8	7	information	information	NOUN
cet-13158	8	8	and	and	CCONJ
cet-13158	8	9	can	can	AUX
cet-13158	8	10	cause	cause	VERB
cet-13158	8	11	a	a	DET
cet-13158	8	12	waste	waste	NOUN
cet-13158	8	13	of	of	ADP
cet-13158	8	14	time	time	NOUN
cet-13158	8	15	and	and	CCONJ
cet-13158	8	16	resources	resource	NOUN
cet-13158	8	17	,	,	PUNCT
cet-13158	8	18	and	and	CCONJ
cet-13158	8	19	even	even	ADV
cet-13158	8	20	misleading	misleading	ADJ
cet-13158	8	21	or	or	CCONJ
cet-13158	8	22	wrong	wrong	ADJ
cet-13158	8	23	conclusions	conclusion	NOUN
cet-13158	8	24	.	.	PUNCT
cet-13158	9	1	therefore	therefore	ADV
cet-13158	9	2	,	,	PUNCT
cet-13158	9	3	it	it	PRON
cet-13158	9	4	is	be	AUX
cet-13158	9	5	crucial	crucial	ADJ
cet-13158	9	6	to	to	PART
cet-13158	9	7	purposefully	purposefully	ADV
cet-13158	9	8	plan	plan	VERB
cet-13158	9	9	experiments	experiment	NOUN
cet-13158	9	10	in	in	ADP
cet-13158	9	11	order	order	NOUN
cet-13158	9	12	to	to	PART
cet-13158	9	13	get	get	VERB
cet-13158	9	14	high	high	ADJ
cet-13158	9	15	quality	quality	NOUN
cet-13158	9	16	experimental	experimental	ADJ
cet-13158	9	17	data	datum	NOUN
cet-13158	9	18	with	with	ADP
cet-13158	9	19	a	a	DET
cet-13158	9	20	maximum	maximum	NOUN
cet-13158	9	21	of	of	ADP
cet-13158	9	22	information	information	NOUN
cet-13158	9	23	.	.	PUNCT
cet-13158	10	1	statistical	statistical	ADJ
cet-13158	10	2	doe	doe	NOUN
cet-13158	10	3	methods	method	NOUN
cet-13158	10	4	such	such	ADJ
cet-13158	10	5	as	as	ADP
cet-13158	10	6	full	full	ADJ
cet-13158	10	7	or	or	CCONJ
cet-13158	10	8	fractional	fractional	ADJ
cet-13158	10	9	factorial	factorial	NOUN
cet-13158	10	10	designs	design	NOUN
cet-13158	10	11	are	be	AUX
cet-13158	10	12	regularly	regularly	ADV
cet-13158	10	13	used	use	VERB
cet-13158	10	14	in	in	ADP
cet-13158	10	15	industrial	industrial	ADJ
cet-13158	10	16	r&d	r&d	NOUN
cet-13158	10	17	processes	process	NOUN
cet-13158	10	18	and	and	CCONJ
cet-13158	10	19	familiar	familiar	ADJ
cet-13158	10	20	to	to	ADP
cet-13158	10	21	most	most	ADJ
cet-13158	10	22	experimental	experimental	ADJ
cet-13158	10	23	chemists	chemist	NOUN
cet-13158	10	24	.	.	PUNCT
cet-13158	11	1	doe	doe	NOUN
cet-13158	11	2	uses	use	VERB
cet-13158	11	3	relatively	relatively	ADV
cet-13158	11	4	simple	simple	ADJ
cet-13158	11	5	correlations	correlation	NOUN
cet-13158	11	6	and	and	CCONJ
cet-13158	11	7	linear	linear	ADJ
cet-13158	11	8	regression	regression	NOUN
cet-13158	11	9	to	to	PART
cet-13158	11	10	model	model	VERB
cet-13158	11	11	the	the	DET
cet-13158	11	12	effects	effect	NOUN
cet-13158	11	13	of	of	ADP
cet-13158	11	14	single	single	ADJ
cet-13158	11	15	factors	factor	NOUN
cet-13158	11	16	and	and	CCONJ
cet-13158	11	17	their	their	PRON
cet-13158	11	18	combinations	combination	NOUN
cet-13158	11	19	on	on	ADP
cet-13158	11	20	dependent	dependent	ADJ
cet-13158	11	21	variables	variable	NOUN
cet-13158	11	22	,	,	PUNCT
cet-13158	11	23	such	such	ADJ
cet-13158	11	24	as	as	ADP
cet-13158	11	25	conversion	conversion	NOUN
cet-13158	11	26	or	or	CCONJ
cet-13158	11	27	yield	yield	NOUN
cet-13158	11	28	.	.	PUNCT
cet-13158	12	1	while	while	SCONJ
cet-13158	12	2	the	the	DET
cet-13158	12	3	resulting	result	VERB
cet-13158	12	4	information	information	NOUN
cet-13158	12	5	allows	allow	VERB
cet-13158	12	6	for	for	ADP
cet-13158	12	7	a	a	DET
cet-13158	12	8	simple	simple	ADJ
cet-13158	12	9	characterization	characterization	NOUN
cet-13158	12	10	of	of	ADP
cet-13158	12	11	the	the	DET
cet-13158	12	12	response	response	NOUN
cet-13158	12	13	surfaces	surface	NOUN
cet-13158	12	14	,	,	PUNCT
cet-13158	12	15	the	the	DET
cet-13158	12	16	nonlinear	nonlinear	ADJ
cet-13158	12	17	behavior	behavior	NOUN
cet-13158	12	18	that	that	PRON
cet-13158	12	19	is	be	AUX
cet-13158	12	20	underlying	underlie	VERB
cet-13158	12	21	most	most	ADJ
cet-13158	12	22	chemical	chemical	ADJ
cet-13158	12	23	or	or	CCONJ
cet-13158	12	24	biochemical	biochemical	ADJ
cet-13158	12	25	reaction	reaction	NOUN
cet-13158	12	26	networks	network	NOUN
cet-13158	12	27	is	be	AUX
cet-13158	12	28	not	not	PART
cet-13158	12	29	necessarily	necessarily	ADV
cet-13158	12	30	well	well	ADV
cet-13158	12	31	presented	present	VERB
cet-13158	12	32	.	.	PUNCT
cet-13158	13	1	optimal	optimal	ADJ
cet-13158	13	2	modelbased	modelbase	VERB
cet-13158	13	3	design	design	NOUN
cet-13158	13	4	of	of	ADP
cet-13158	13	5	experiment	experiment	NOUN
cet-13158	13	6	(	(	PUNCT
cet-13158	13	7	mbdoe	mbdoe	NOUN
cet-13158	13	8	)	)	PUNCT
cet-13158	13	9	methods	method	NOUN
cet-13158	13	10	are	be	AUX
cet-13158	13	11	explicitly	explicitly	ADV
cet-13158	13	12	developed	develop	VERB
cet-13158	13	13	to	to	PART
cet-13158	13	14	exploit	exploit	VERB
cet-13158	13	15	the	the	DET
cet-13158	13	16	structure	structure	NOUN
cet-13158	13	17	of	of	ADP
cet-13158	13	18	mechanistic	mechanistic	ADJ
cet-13158	13	19	nonlinear	nonlinear	ADJ
cet-13158	13	20	and	and	CCONJ
cet-13158	13	21	dynamic	dynamic	ADJ
cet-13158	13	22	process	process	NOUN
cet-13158	13	23	models	model	NOUN
cet-13158	13	24	.	.	PUNCT
cet-13158	14	1	these	these	DET
cet-13158	14	2	methods	method	NOUN
cet-13158	14	3	have	have	AUX
cet-13158	14	4	secured	secure	VERB
cet-13158	14	5	huge	huge	ADJ
cet-13158	14	6	attention	attention	NOUN
cet-13158	14	7	in	in	ADP
cet-13158	14	8	almost	almost	ADV
cet-13158	14	9	all	all	PRON
cet-13158	14	10	fields	field	NOUN
cet-13158	14	11	of	of	ADP
cet-13158	14	12	studies	study	NOUN
cet-13158	14	13	,	,	PUNCT
cet-13158	14	14	particularly	particularly	ADV
cet-13158	14	15	in	in	ADP
cet-13158	14	16	biochemical	biochemical	ADJ
cet-13158	14	17	disciplines	discipline	NOUN
cet-13158	14	18	(	(	PUNCT
cet-13158	14	19	franceschini	franceschini	NOUN
cet-13158	14	20	and	and	CCONJ
cet-13158	14	21	macchietto	macchietto	ADJ
cet-13158	14	22	,	,	PUNCT
cet-13158	14	23	2008	2008	NUM
cet-13158	14	24	)	)	PUNCT
cet-13158	14	25	.	.	PUNCT
cet-13158	15	1	the	the	DET
cet-13158	15	2	application	application	NOUN
cet-13158	15	3	of	of	ADP
cet-13158	15	4	mbdoe	mbdoe	NOUN
cet-13158	15	5	is	be	AUX
cet-13158	15	6	especially	especially	ADV
cet-13158	15	7	suitable	suitable	ADJ
cet-13158	15	8	for	for	ADP
cet-13158	15	9	continuous	continuous	ADJ
cet-13158	15	10	flow	flow	NOUN
cet-13158	15	11	reactors	reactor	NOUN
cet-13158	15	12	which	which	PRON
cet-13158	15	13	offer	offer	VERB
cet-13158	15	14	excellent	excellent	ADJ
cet-13158	15	15	prerequisites	prerequisite	NOUN
cet-13158	15	16	for	for	ADP
cet-13158	15	17	fast	fast	ADJ
cet-13158	15	18	and	and	CCONJ
cet-13158	15	19	efficient	efficient	ADJ
cet-13158	15	20	experiments	experiment	NOUN
cet-13158	15	21	under	under	ADP
cet-13158	15	22	well	well	ADV
cet-13158	15	23	-	-	PUNCT
cet-13158	15	24	defined	define	VERB
cet-13158	15	25	process	process	NOUN
cet-13158	15	26	conditions	condition	NOUN
cet-13158	15	27	enabled	enable	VERB
cet-13158	15	28	by	by	ADP
cet-13158	15	29	an	an	DET
cet-13158	15	30	enhanced	enhanced	ADJ
cet-13158	15	31	heat	heat	NOUN
cet-13158	15	32	and	and	CCONJ
cet-13158	15	33	mass	mass	NOUN
cet-13158	15	34	transfer	transfer	NOUN
cet-13158	15	35	(	(	PUNCT
cet-13158	15	36	fath	fath	PROPN
cet-13158	15	37	et	et	PROPN
cet-13158	15	38	al	al	PROPN
cet-13158	15	39	.	.	PROPN
cet-13158	15	40	,	,	PUNCT
cet-13158	15	41	2020	2020	NUM
cet-13158	15	42	)	)	PUNCT
cet-13158	15	43	.	.	PUNCT
cet-13158	16	1	the	the	DET
cet-13158	16	2	combination	combination	NOUN
cet-13158	16	3	of	of	ADP
cet-13158	16	4	mbdoe	mbdoe	NOUN
cet-13158	16	5	with	with	ADP
cet-13158	16	6	flow	flow	NOUN
cet-13158	16	7	reactors	reactor	NOUN
cet-13158	16	8	supports	support	VERB
cet-13158	16	9	quick	quick	ADJ
cet-13158	16	10	development	development	NOUN
cet-13158	16	11	,	,	PUNCT
cet-13158	16	12	modification	modification	NOUN
cet-13158	16	13	and	and	CCONJ
cet-13158	16	14	statistical	statistical	ADJ
cet-13158	16	15	validation	validation	NOUN
cet-13158	16	16	of	of	ADP
cet-13158	16	17	linear	linear	PROPN
cet-13158	16	18	or	or	CCONJ
cet-13158	16	19	nonlinear	nonlinear	ADJ
cet-13158	16	20	,	,	PUNCT
cet-13158	16	21	and	and	CCONJ
cet-13158	16	22	static	static	ADJ
cet-13158	16	23	or	or	CCONJ
cet-13158	16	24	dynamic	dynamic	ADJ
cet-13158	16	25	models	model	NOUN
cet-13158	16	26	.	.	PUNCT
cet-13158	17	1	the	the	DET
cet-13158	17	2	main	main	ADJ
cet-13158	17	3	benefits	benefit	NOUN
cet-13158	17	4	of	of	ADP
cet-13158	17	5	mbdoe	mbdoe	NOUN
cet-13158	17	6	in	in	ADP
cet-13158	17	7	comparison	comparison	NOUN
cet-13158	17	8	to	to	ADP
cet-13158	17	9	statistical	statistical	ADJ
cet-13158	17	10	design	design	NOUN
cet-13158	17	11	methods	method	NOUN
cet-13158	17	12	are	be	AUX
cet-13158	17	13	the	the	DET
cet-13158	17	14	use	use	NOUN
cet-13158	17	15	of	of	ADP
cet-13158	17	16	prior	prior	ADJ
cet-13158	17	17	model	model	NOUN
cet-13158	17	18	information	information	NOUN
cet-13158	17	19	,	,	PUNCT
cet-13158	17	20	especially	especially	ADV
cet-13158	17	21	exploiting	exploit	VERB
cet-13158	17	22	known	know	VERB
cet-13158	17	23	model	model	NOUN
cet-13158	17	24	structure	structure	NOUN
cet-13158	17	25	,	,	PUNCT
cet-13158	17	26	the	the	DET
cet-13158	17	27	possible	possible	ADJ
cet-13158	17	28	application	application	NOUN
cet-13158	17	29	to	to	ADP
cet-13158	17	30	complex	complex	ADJ
cet-13158	17	31	systems	system	NOUN
cet-13158	17	32	,	,	PUNCT
cet-13158	17	33	i.e.	i.e.	X
cet-13158	17	34	nonlinear	nonlinear	ADJ
cet-13158	17	35	,	,	PUNCT
cet-13158	17	36	dynamic	dynamic	ADJ
cet-13158	17	37	and	and	CCONJ
cet-13158	17	38	multi	multi	ADJ
cet-13158	17	39	-	-	ADJ
cet-13158	17	40	dimensional	dimensional	ADJ
cet-13158	17	41	systems	system	NOUN
cet-13158	17	42	,	,	PUNCT
cet-13158	17	43	as	as	ADV
cet-13158	17	44	well	well	ADV
cet-13158	17	45	as	as	ADP
cet-13158	17	46	the	the	DET
cet-13158	17	47	consideration	consideration	NOUN
cet-13158	17	48	of	of	ADP
cet-13158	17	49	different	different	ADJ
cet-13158	17	50	objective	objective	ADJ
cet-13158	17	51	functions	function	NOUN
cet-13158	17	52	,	,	PUNCT
cet-13158	17	53	e.g.	e.g.	ADV
cet-13158	17	54	for	for	ADP
cet-13158	17	55	model	model	NOUN
cet-13158	17	56	discrimination	discrimination	NOUN
cet-13158	17	57	and	and	CCONJ
cet-13158	17	58	parameter	parameter	NOUN
cet-13158	17	59	estimation	estimation	NOUN
cet-13158	17	60	,	,	PUNCT
cet-13158	17	61	which	which	PRON
cet-13158	17	62	enable	enable	VERB
cet-13158	17	63	numerical	numerical	ADJ
cet-13158	17	64	optimisation	optimisation	NOUN
cet-13158	17	65	frameworks	framework	NOUN
cet-13158	17	66	(	(	PUNCT
cet-13158	17	67	yu	yu	NOUN
cet-13158	17	68	,	,	PUNCT
cet-13158	17	69	2018	2018	NUM
cet-13158	17	70	)	)	PUNCT
cet-13158	17	71	.	.	PUNCT
cet-13158	18	1	475	475	NUM
cet-13158	18	2	in	in	ADP
cet-13158	18	3	any	any	DET
cet-13158	18	4	case	case	NOUN
cet-13158	18	5	,	,	PUNCT
cet-13158	18	6	the	the	DET
cet-13158	18	7	main	main	ADJ
cet-13158	18	8	purpose	purpose	NOUN
cet-13158	18	9	of	of	ADP
cet-13158	18	10	mbdoe	mbdoe	NOUN
cet-13158	18	11	is	be	AUX
cet-13158	18	12	to	to	PART
cet-13158	18	13	optimally	optimally	ADV
cet-13158	18	14	design	design	VERB
cet-13158	18	15	experiments	experiment	NOUN
cet-13158	18	16	that	that	PRON
cet-13158	18	17	return	return	VERB
cet-13158	18	18	the	the	DET
cet-13158	18	19	highest	high	ADJ
cet-13158	18	20	information	information	NOUN
cet-13158	18	21	content	content	NOUN
cet-13158	18	22	for	for	ADP
cet-13158	18	23	the	the	DET
cet-13158	18	24	identification	identification	NOUN
cet-13158	18	25	of	of	ADP
cet-13158	18	26	a	a	DET
cet-13158	18	27	suitable	suitable	ADJ
cet-13158	18	28	model	model	NOUN
cet-13158	18	29	.	.	PUNCT
cet-13158	19	1	in	in	ADP
cet-13158	19	2	the	the	DET
cet-13158	19	3	context	context	NOUN
cet-13158	19	4	of	of	ADP
cet-13158	19	5	reaction	reaction	NOUN
cet-13158	19	6	kinetics	kinetic	NOUN
cet-13158	19	7	,	,	PUNCT
cet-13158	19	8	mbdoe	mbdoe	NOUN
cet-13158	19	9	is	be	AUX
cet-13158	19	10	manly	manly	ADV
cet-13158	19	11	applied	apply	VERB
cet-13158	19	12	for	for	ADP
cet-13158	19	13	model	model	NOUN
cet-13158	19	14	discrimination	discrimination	NOUN
cet-13158	19	15	and	and	CCONJ
cet-13158	19	16	parameter	parameter	NOUN
cet-13158	19	17	estimation	estimation	NOUN
cet-13158	19	18	.	.	PUNCT
cet-13158	20	1	the	the	DET
cet-13158	20	2	aim	aim	NOUN
cet-13158	20	3	of	of	ADP
cet-13158	20	4	model	model	NOUN
cet-13158	20	5	discrimination	discrimination	NOUN
cet-13158	20	6	is	be	AUX
cet-13158	20	7	to	to	PART
cet-13158	20	8	distinguish	distinguish	VERB
cet-13158	20	9	between	between	ADP
cet-13158	20	10	different	different	ADJ
cet-13158	20	11	model	model	NOUN
cet-13158	20	12	structures	structure	NOUN
cet-13158	20	13	and	and	CCONJ
cet-13158	20	14	select	select	VERB
cet-13158	20	15	the	the	DET
cet-13158	20	16	most	most	ADV
cet-13158	20	17	suitable	suitable	ADJ
cet-13158	20	18	model	model	NOUN
cet-13158	20	19	.	.	PUNCT
cet-13158	21	1	design	design	NOUN
cet-13158	21	2	criteria	criterion	NOUN
cet-13158	21	3	for	for	ADP
cet-13158	21	4	parameter	parameter	NOUN
cet-13158	21	5	estimation	estimation	NOUN
cet-13158	21	6	aim	aim	VERB
cet-13158	21	7	to	to	PART
cet-13158	21	8	improve	improve	VERB
cet-13158	21	9	the	the	DET
cet-13158	21	10	accuracy	accuracy	NOUN
cet-13158	21	11	for	for	ADP
cet-13158	21	12	the	the	DET
cet-13158	21	13	parameter	parameter	NOUN
cet-13158	21	14	estimation	estimation	NOUN
cet-13158	21	15	of	of	ADP
cet-13158	21	16	a	a	DET
cet-13158	21	17	given	give	VERB
cet-13158	21	18	model	model	NOUN
cet-13158	21	19	.	.	PUNCT
cet-13158	22	1	due	due	ADP
cet-13158	22	2	to	to	ADP
cet-13158	22	3	the	the	DET
cet-13158	22	4	fact	fact	NOUN
cet-13158	22	5	,	,	PUNCT
cet-13158	22	6	that	that	SCONJ
cet-13158	22	7	prior	prior	ADJ
cet-13158	22	8	information	information	NOUN
cet-13158	22	9	is	be	AUX
cet-13158	22	10	given	give	VERB
cet-13158	22	11	about	about	ADP
cet-13158	22	12	the	the	DET
cet-13158	22	13	reaction	reaction	NOUN
cet-13158	22	14	order	order	NOUN
cet-13158	22	15	of	of	ADP
cet-13158	22	16	the	the	DET
cet-13158	22	17	kinetic	kinetic	ADJ
cet-13158	22	18	model	model	NOUN
cet-13158	22	19	to	to	PART
cet-13158	22	20	be	be	AUX
cet-13158	22	21	dealt	deal	VERB
cet-13158	22	22	with	with	ADP
cet-13158	22	23	in	in	ADP
cet-13158	22	24	this	this	DET
cet-13158	22	25	study	study	NOUN
cet-13158	22	26	,	,	PUNCT
cet-13158	22	27	the	the	DET
cet-13158	22	28	focus	focus	NOUN
cet-13158	22	29	is	be	AUX
cet-13158	22	30	to	to	PART
cet-13158	22	31	design	design	VERB
cet-13158	22	32	experiments	experiment	NOUN
cet-13158	22	33	which	which	PRON
cet-13158	22	34	help	help	VERB
cet-13158	22	35	to	to	PART
cet-13158	22	36	precise	precise	VERB
cet-13158	22	37	the	the	DET
cet-13158	22	38	accuracy	accuracy	NOUN
cet-13158	22	39	of	of	ADP
cet-13158	22	40	the	the	DET
cet-13158	22	41	parameter	parameter	NOUN
cet-13158	22	42	estimation	estimation	NOUN
cet-13158	22	43	.	.	PUNCT
cet-13158	23	1	the	the	DET
cet-13158	23	2	objective	objective	ADJ
cet-13158	23	3	criteria	criterion	NOUN
cet-13158	23	4	for	for	ADP
cet-13158	23	5	designing	design	VERB
cet-13158	23	6	optimal	optimal	ADJ
cet-13158	23	7	experiments	experiment	NOUN
cet-13158	23	8	to	to	PART
cet-13158	23	9	improve	improve	VERB
cet-13158	23	10	the	the	DET
cet-13158	23	11	parameter	parameter	NOUN
cet-13158	23	12	estimation	estimation	NOUN
cet-13158	23	13	is	be	AUX
cet-13158	23	14	mostly	mostly	ADV
cet-13158	23	15	based	base	VERB
cet-13158	23	16	on	on	ADP
cet-13158	23	17	the	the	DET
cet-13158	23	18	fisher	fisher	PROPN
cet-13158	23	19	information	information	NOUN
cet-13158	23	20	matrix	matrix	NOUN
cet-13158	23	21	(	(	PUNCT
cet-13158	23	22	fim	fim	NOUN
cet-13158	23	23	)	)	PUNCT
cet-13158	23	24	,	,	PUNCT
cet-13158	23	25	which	which	PRON
cet-13158	23	26	is	be	AUX
cet-13158	23	27	derived	derive	VERB
cet-13158	23	28	from	from	ADP
cet-13158	23	29	the	the	DET
cet-13158	23	30	sensitivity	sensitivity	NOUN
cet-13158	23	31	matrix	matrix	NOUN
cet-13158	23	32	taking	take	VERB
cet-13158	23	33	into	into	ADP
cet-13158	23	34	account	account	NOUN
cet-13158	23	35	the	the	DET
cet-13158	23	36	partial	partial	ADJ
cet-13158	23	37	derivatives	derivative	NOUN
cet-13158	23	38	of	of	ADP
cet-13158	23	39	the	the	DET
cet-13158	23	40	model	model	NOUN
cet-13158	23	41	response	response	NOUN
cet-13158	23	42	with	with	ADP
cet-13158	23	43	respect	respect	NOUN
cet-13158	23	44	to	to	ADP
cet-13158	23	45	the	the	DET
cet-13158	23	46	model	model	NOUN
cet-13158	23	47	parameters	parameter	NOUN
cet-13158	23	48	.	.	PUNCT
cet-13158	24	1	in	in	ADP
cet-13158	24	2	case	case	NOUN
cet-13158	24	3	no	no	DET
cet-13158	24	4	explicit	explicit	ADJ
cet-13158	24	5	solution	solution	NOUN
cet-13158	24	6	of	of	ADP
cet-13158	24	7	the	the	DET
cet-13158	24	8	derivative	derivative	NOUN
cet-13158	24	9	is	be	AUX
cet-13158	24	10	obtainable	obtainable	ADJ
cet-13158	24	11	,	,	PUNCT
cet-13158	24	12	the	the	DET
cet-13158	24	13	parameter	parameter	NOUN
cet-13158	24	14	sensitives	sensitive	NOUN
cet-13158	24	15	can	can	AUX
cet-13158	24	16	be	be	AUX
cet-13158	24	17	calculated	calculate	VERB
cet-13158	24	18	numerically	numerically	ADV
cet-13158	24	19	,	,	PUNCT
cet-13158	24	20	e.g.	e.g.	ADV
cet-13158	24	21	with	with	ADP
cet-13158	24	22	the	the	DET
cet-13158	24	23	complex	complex	ADJ
cet-13158	24	24	step	step	NOUN
cet-13158	24	25	approximation	approximation	NOUN
cet-13158	24	26	(	(	PUNCT
cet-13158	24	27	martins	martin	NOUN
cet-13158	24	28	et	et	NOUN
cet-13158	24	29	al	al	PROPN
cet-13158	24	30	.	.	PROPN
cet-13158	24	31	,	,	PUNCT
cet-13158	24	32	2003	2003	NUM
cet-13158	24	33	)	)	PUNCT
cet-13158	24	34	.	.	PUNCT
cet-13158	25	1	in	in	ADP
cet-13158	25	2	the	the	DET
cet-13158	25	3	current	current	ADJ
cet-13158	25	4	work	work	NOUN
cet-13158	25	5	,	,	PUNCT
cet-13158	25	6	a	a	DET
cet-13158	25	7	mbdoe	mbdoe	NOUN
cet-13158	25	8	based	base	VERB
cet-13158	25	9	on	on	ADP
cet-13158	25	10	the	the	DET
cet-13158	25	11	d	d	NOUN
cet-13158	25	12	-	-	PUNCT
cet-13158	25	13	optimality	optimality	NOUN
cet-13158	25	14	criteria	criterion	NOUN
cet-13158	25	15	is	be	AUX
cet-13158	25	16	applied	apply	VERB
cet-13158	25	17	for	for	ADP
cet-13158	25	18	parameter	parameter	NOUN
cet-13158	25	19	estimation	estimation	NOUN
cet-13158	25	20	,	,	PUNCT
cet-13158	25	21	aiming	aim	VERB
cet-13158	25	22	to	to	PART
cet-13158	25	23	minimize	minimize	VERB
cet-13158	25	24	the	the	DET
cet-13158	25	25	volume	volume	NOUN
cet-13158	25	26	of	of	ADP
cet-13158	25	27	the	the	DET
cet-13158	25	28	confidence	confidence	NOUN
cet-13158	25	29	ellipsoid	ellipsoid	NOUN
cet-13158	25	30	for	for	ADP
cet-13158	25	31	the	the	DET
cet-13158	25	32	estimated	estimate	VERB
cet-13158	25	33	parameter	parameter	NOUN
cet-13158	25	34	errors	error	NOUN
cet-13158	25	35	.	.	PUNCT
cet-13158	26	1	2	2	X
cet-13158	26	2	.	.	X
cet-13158	26	3	materials	material	NOUN
cet-13158	26	4	and	and	CCONJ
cet-13158	26	5	methods	method	NOUN
cet-13158	26	6	2.1	2.1	NUM
cet-13158	26	7	art	art	NOUN
cet-13158	26	8	plate	plate	NOUN
cet-13158	26	9	reactor	reactor	NOUN
cet-13158	26	10	pr37	pr37	PROPN
cet-13158	26	11	in	in	ADP
cet-13158	26	12	order	order	NOUN
cet-13158	26	13	to	to	PART
cet-13158	26	14	combine	combine	VERB
cet-13158	26	15	intensified	intensify	VERB
cet-13158	26	16	reactor	reactor	NOUN
cet-13158	26	17	equipment	equipment	NOUN
cet-13158	26	18	and	and	CCONJ
cet-13158	26	19	experimental	experimental	ADJ
cet-13158	26	20	design	design	NOUN
cet-13158	26	21	,	,	PUNCT
cet-13158	26	22	the	the	DET
cet-13158	26	23	current	current	ADJ
cet-13158	26	24	work	work	NOUN
cet-13158	26	25	focuses	focus	VERB
cet-13158	26	26	on	on	ADP
cet-13158	26	27	the	the	DET
cet-13158	26	28	kinetic	kinetic	ADJ
cet-13158	26	29	investigation	investigation	NOUN
cet-13158	26	30	of	of	ADP
cet-13158	26	31	a	a	DET
cet-13158	26	32	multi	multi	ADJ
cet-13158	26	33	-	-	ADJ
cet-13158	26	34	step	step	ADJ
cet-13158	26	35	reaction	reaction	NOUN
cet-13158	26	36	in	in	ADP
cet-13158	26	37	the	the	DET
cet-13158	26	38	art	art	NOUN
cet-13158	26	39	plate	plate	NOUN
cet-13158	26	40	reactor	reactor	NOUN
cet-13158	26	41	pr37	pr37	PROPN
cet-13158	26	42	from	from	ADP
cet-13158	26	43	ehrfeld	ehrfeld	VERB
cet-13158	26	44	mikrotechnik	mikrotechnik	ADJ
cet-13158	26	45	gmbh	gmbh	PROPN
cet-13158	26	46	,	,	PUNCT
cet-13158	26	47	which	which	PRON
cet-13158	26	48	is	be	AUX
cet-13158	26	49	designed	design	VERB
cet-13158	26	50	as	as	ADP
cet-13158	26	51	an	an	DET
cet-13158	26	52	integrated	integrated	ADJ
cet-13158	26	53	heat	heat	NOUN
cet-13158	26	54	exchanger	exchanger	NOUN
cet-13158	26	55	and	and	CCONJ
cet-13158	26	56	reactor	reactor	NOUN
cet-13158	26	57	.	.	PUNCT
cet-13158	27	1	the	the	DET
cet-13158	27	2	art	art	NOUN
cet-13158	27	3	pr37	pr37	PROPN
cet-13158	27	4	has	have	VERB
cet-13158	27	5	a	a	DET
cet-13158	27	6	modular	modular	ADJ
cet-13158	27	7	design	design	NOUN
cet-13158	27	8	and	and	CCONJ
cet-13158	27	9	can	can	AUX
cet-13158	27	10	integrate	integrate	VERB
cet-13158	27	11	up	up	ADP
cet-13158	27	12	to	to	PART
cet-13158	27	13	10	10	NUM
cet-13158	27	14	reactor	reactor	NOUN
cet-13158	27	15	plates	plate	NOUN
cet-13158	27	16	.	.	PUNCT
cet-13158	28	1	the	the	DET
cet-13158	28	2	process	process	NOUN
cet-13158	28	3	channel	channel	NOUN
cet-13158	28	4	is	be	AUX
cet-13158	28	5	characterized	characterize	VERB
cet-13158	28	6	by	by	ADP
cet-13158	28	7	a	a	DET
cet-13158	28	8	meandering	meandering	NOUN
cet-13158	28	9	,	,	PUNCT
cet-13158	28	10	periodically	periodically	ADV
cet-13158	28	11	diverging/	diverging/	NUM
cet-13158	28	12	converging	converge	VERB
cet-13158	28	13	structure	structure	NOUN
cet-13158	28	14	which	which	PRON
cet-13158	28	15	promotes	promote	VERB
cet-13158	28	16	the	the	DET
cet-13158	28	17	formation	formation	NOUN
cet-13158	28	18	of	of	ADP
cet-13158	28	19	secondary	secondary	ADJ
cet-13158	28	20	flows	flow	NOUN
cet-13158	28	21	leading	lead	VERB
cet-13158	28	22	to	to	ADP
cet-13158	28	23	an	an	DET
cet-13158	28	24	intensification	intensification	NOUN
cet-13158	28	25	of	of	ADP
cet-13158	28	26	transport	transport	NOUN
cet-13158	28	27	processes	process	NOUN
cet-13158	28	28	.	.	PUNCT
cet-13158	29	1	the	the	DET
cet-13158	29	2	utility	utility	NOUN
cet-13158	29	3	channel	channel	NOUN
cet-13158	29	4	is	be	AUX
cet-13158	29	5	located	locate	VERB
cet-13158	29	6	below	below	ADV
cet-13158	29	7	and	and	CCONJ
cet-13158	29	8	contains	contain	VERB
cet-13158	29	9	a	a	DET
cet-13158	29	10	tubular	tubular	ADJ
cet-13158	29	11	grid	grid	NOUN
cet-13158	29	12	that	that	PRON
cet-13158	29	13	improves	improve	VERB
cet-13158	29	14	the	the	DET
cet-13158	29	15	cross	cross	NOUN
cet-13158	29	16	-	-	ADJ
cet-13158	29	17	mixing	mixing	NOUN
cet-13158	29	18	of	of	ADP
cet-13158	29	19	the	the	DET
cet-13158	29	20	tempering	temper	VERB
cet-13158	29	21	medium	medium	NOUN
cet-13158	29	22	and	and	CCONJ
cet-13158	29	23	thus	thus	ADV
cet-13158	29	24	the	the	DET
cet-13158	29	25	heat	heat	NOUN
cet-13158	29	26	transfer	transfer	NOUN
cet-13158	29	27	.	.	PUNCT
cet-13158	30	1	four	four	NUM
cet-13158	30	2	different	different	ADJ
cet-13158	30	3	type	type	NOUN
cet-13158	30	4	of	of	ADP
cet-13158	30	5	plates	plate	NOUN
cet-13158	30	6	are	be	AUX
cet-13158	30	7	available	available	ADJ
cet-13158	30	8	(	(	PUNCT
cet-13158	30	9	pl37	pl37	PROPN
cet-13158	30	10	-	-	PUNCT
cet-13158	30	11	08	08	PROPN
cet-13158	30	12	,	,	PUNCT
cet-13158	30	13	pl37	pl37	PROPN
cet-13158	30	14	-	-	PUNCT
cet-13158	30	15	3	3	PROPN
cet-13158	30	16	,	,	PUNCT
cet-13158	30	17	pl37	pl37	PROPN
cet-13158	30	18	-	-	PUNCT
cet-13158	30	19	6	6	NUM
cet-13158	30	20	and	and	CCONJ
cet-13158	30	21	pl37	pl37	PROPN
cet-13158	30	22	-	-	PUNCT
cet-13158	30	23	12	12	NUM
cet-13158	30	24	)	)	PUNCT
cet-13158	30	25	which	which	PRON
cet-13158	30	26	have	have	VERB
cet-13158	30	27	similar	similar	ADJ
cet-13158	30	28	geometry	geometry	NOUN
cet-13158	30	29	and	and	CCONJ
cet-13158	30	30	only	only	ADV
cet-13158	30	31	differ	differ	VERB
cet-13158	30	32	in	in	ADP
cet-13158	30	33	the	the	DET
cet-13158	30	34	depth	depth	NOUN
cet-13158	30	35	of	of	ADP
cet-13158	30	36	the	the	DET
cet-13158	30	37	process	process	NOUN
cet-13158	30	38	channel	channel	NOUN
cet-13158	30	39	and	and	CCONJ
cet-13158	30	40	the	the	DET
cet-13158	30	41	respective	respective	ADJ
cet-13158	30	42	cross	cross	ADJ
cet-13158	30	43	-	-	ADJ
cet-13158	30	44	sectional	sectional	ADJ
cet-13158	30	45	area	area	NOUN
cet-13158	30	46	.	.	PUNCT
cet-13158	31	1	this	this	PRON
cet-13158	31	2	allows	allow	VERB
cet-13158	31	3	a	a	DET
cet-13158	31	4	straight	straight	ADJ
cet-13158	31	5	forward	forward	ADJ
cet-13158	31	6	scale	scale	NOUN
cet-13158	31	7	-	-	PUNCT
cet-13158	31	8	up	up	NOUN
cet-13158	31	9	of	of	ADP
cet-13158	31	10	the	the	DET
cet-13158	31	11	process	process	NOUN
cet-13158	31	12	,	,	PUNCT
cet-13158	31	13	which	which	PRON
cet-13158	31	14	is	be	AUX
cet-13158	31	15	even	even	ADV
cet-13158	31	16	transferable	transferable	ADJ
cet-13158	31	17	to	to	ADP
cet-13158	31	18	the	the	DET
cet-13158	31	19	production	production	NOUN
cet-13158	31	20	scale	scale	NOUN
cet-13158	31	21	art	art	NOUN
cet-13158	31	22	plate	plate	NOUN
cet-13158	31	23	reactor	reactor	NOUN
cet-13158	31	24	pr49	pr49	PROPN
cet-13158	31	25	(	(	PUNCT
cet-13158	31	26	rave	rave	VERB
cet-13158	31	27	et	et	PROPN
cet-13158	31	28	al	al	PROPN
cet-13158	31	29	.	.	PROPN
cet-13158	31	30	,	,	PUNCT
cet-13158	31	31	2019	2019	NUM
cet-13158	31	32	)	)	PUNCT
cet-13158	31	33	.	.	PUNCT
cet-13158	32	1	the	the	DET
cet-13158	32	2	reactor	reactor	NOUN
cet-13158	32	3	plates	plate	NOUN
cet-13158	32	4	are	be	AUX
cet-13158	32	5	stacked	stack	VERB
cet-13158	32	6	up	up	ADP
cet-13158	32	7	in	in	ADP
cet-13158	32	8	a	a	DET
cet-13158	32	9	frame	frame	NOUN
cet-13158	32	10	and	and	CCONJ
cet-13158	32	11	braced	brace	VERB
cet-13158	32	12	by	by	ADP
cet-13158	32	13	tension	tension	NOUN
cet-13158	32	14	rods	rod	NOUN
cet-13158	32	15	.	.	PUNCT
cet-13158	33	1	due	due	ADP
cet-13158	33	2	to	to	ADP
cet-13158	33	3	its	its	PRON
cet-13158	33	4	robust	robust	ADJ
cet-13158	33	5	design	design	NOUN
cet-13158	33	6	made	make	VERB
cet-13158	33	7	of	of	ADP
cet-13158	33	8	stainless	stainless	ADJ
cet-13158	33	9	steel	steel	NOUN
cet-13158	33	10	(	(	PUNCT
cet-13158	33	11	ss	ss	NOUN
cet-13158	33	12	316	316	NUM
cet-13158	33	13	l	l	NOUN
cet-13158	33	14	)	)	PUNCT
cet-13158	33	15	or	or	CCONJ
cet-13158	33	16	hastelloy	hastelloy	PROPN
cet-13158	33	17	(	(	PUNCT
cet-13158	33	18	c-22	c-22	PROPN
cet-13158	33	19	)	)	PUNCT
cet-13158	33	20	,	,	PUNCT
cet-13158	33	21	the	the	DET
cet-13158	33	22	reactor	reactor	NOUN
cet-13158	33	23	is	be	AUX
cet-13158	33	24	suitable	suitable	ADJ
cet-13158	33	25	for	for	ADP
cet-13158	33	26	the	the	DET
cet-13158	33	27	processing	processing	NOUN
cet-13158	33	28	of	of	ADP
cet-13158	33	29	aggressive	aggressive	ADJ
cet-13158	33	30	media	medium	NOUN
cet-13158	33	31	with	with	ADP
cet-13158	33	32	pressures	pressure	NOUN
cet-13158	33	33	up	up	ADP
cet-13158	33	34	to	to	PART
cet-13158	33	35	20	20	NUM
cet-13158	33	36	bar	bar	NOUN
cet-13158	33	37	on	on	ADP
cet-13158	33	38	the	the	DET
cet-13158	33	39	process	process	NOUN
cet-13158	33	40	side	side	NOUN
cet-13158	33	41	and	and	CCONJ
cet-13158	33	42	to	to	ADP
cet-13158	33	43	10	10	NUM
cet-13158	33	44	bar	bar	NOUN
cet-13158	33	45	on	on	ADP
cet-13158	33	46	the	the	DET
cet-13158	33	47	utility	utility	NOUN
cet-13158	33	48	side	side	NOUN
cet-13158	33	49	,	,	PUNCT
cet-13158	33	50	as	as	ADV
cet-13158	33	51	well	well	ADV
cet-13158	33	52	as	as	ADP
cet-13158	33	53	temperatures	temperature	NOUN
cet-13158	33	54	between	between	ADP
cet-13158	33	55	-60	-60	PUNCT
cet-13158	33	56	and	and	CCONJ
cet-13158	33	57	200	200	NUM
cet-13158	33	58	°	°	NOUN
cet-13158	33	59	c	c	NOUN
cet-13158	33	60	.	.	PUNCT
cet-13158	34	1	the	the	DET
cet-13158	34	2	reactor	reactor	NOUN
cet-13158	34	3	has	have	AUX
cet-13158	34	4	been	be	AUX
cet-13158	34	5	investigated	investigate	VERB
cet-13158	34	6	systematically	systematically	ADV
cet-13158	34	7	in	in	ADP
cet-13158	34	8	terms	term	NOUN
cet-13158	34	9	of	of	ADP
cet-13158	34	10	heat	heat	NOUN
cet-13158	34	11	and	and	CCONJ
cet-13158	34	12	mass	mass	NOUN
cet-13158	34	13	transfer	transfer	NOUN
cet-13158	34	14	,	,	PUNCT
cet-13158	34	15	demonstrating	demonstrate	VERB
cet-13158	34	16	high	high	ADJ
cet-13158	34	17	heat	heat	NOUN
cet-13158	34	18	transfer	transfer	NOUN
cet-13158	34	19	coefficients	coefficient	NOUN
cet-13158	34	20	of	of	ADP
cet-13158	34	21	about	about	ADV
cet-13158	34	22	5	5	NUM
cet-13158	34	23	kw	kw	NOUN
cet-13158	34	24	m-2	m-2	NOUN
cet-13158	34	25	k-1	k-1	PROPN
cet-13158	34	26	at	at	ADP
cet-13158	34	27	moderate	moderate	ADJ
cet-13158	34	28	reynolds	reynolds	PROPN
cet-13158	34	29	numbers	number	NOUN
cet-13158	34	30	(	(	PUNCT
cet-13158	34	31	rave	rave	NOUN
cet-13158	34	32	et	et	PROPN
cet-13158	34	33	al	al	PROPN
cet-13158	34	34	.	.	PROPN
cet-13158	34	35	,	,	PUNCT
cet-13158	34	36	2020	2020	NUM
cet-13158	34	37	)	)	PUNCT
cet-13158	34	38	and	and	CCONJ
cet-13158	34	39	micromixing	micromixing	NOUN
cet-13158	34	40	times	time	NOUN
cet-13158	34	41	below	below	ADP
cet-13158	34	42	0,1	0,1	NUM
cet-13158	34	43	s	s	PART
cet-13158	34	44	for	for	ADP
cet-13158	34	45	reynolds	reynold	NOUN
cet-13158	34	46	numbers	number	NOUN
cet-13158	34	47	higher	high	ADJ
cet-13158	34	48	150	150	NUM
cet-13158	34	49	(	(	PUNCT
cet-13158	34	50	rave	rave	NOUN
cet-13158	34	51	et	et	PROPN
cet-13158	34	52	al	al	PROPN
cet-13158	34	53	.	.	PROPN
cet-13158	34	54	,	,	PUNCT
cet-13158	34	55	2022	2022	NUM
cet-13158	34	56	)	)	PUNCT
cet-13158	34	57	.	.	PUNCT
cet-13158	35	1	this	this	PRON
cet-13158	35	2	demonstrates	demonstrate	VERB
cet-13158	35	3	the	the	DET
cet-13158	35	4	excellent	excellent	ADJ
cet-13158	35	5	suitability	suitability	NOUN
cet-13158	35	6	of	of	ADP
cet-13158	35	7	the	the	DET
cet-13158	35	8	art	art	NOUN
cet-13158	35	9	reactor	reactor	NOUN
cet-13158	35	10	for	for	ADP
cet-13158	35	11	strongly	strongly	ADV
cet-13158	35	12	exothermic	exothermic	ADJ
cet-13158	35	13	reactions	reaction	NOUN
cet-13158	35	14	and	and	CCONJ
cet-13158	35	15	fast	fast	ADJ
cet-13158	35	16	,	,	PUNCT
cet-13158	35	17	mixing	mix	VERB
cet-13158	35	18	-	-	PUNCT
cet-13158	35	19	sensitive	sensitive	ADJ
cet-13158	35	20	reactions	reaction	NOUN
cet-13158	35	21	.	.	PUNCT
cet-13158	36	1	moreover	moreover	ADV
cet-13158	36	2	,	,	PUNCT
cet-13158	36	3	it	it	PRON
cet-13158	36	4	was	be	AUX
cet-13158	36	5	found	find	VERB
cet-13158	36	6	,	,	PUNCT
cet-13158	36	7	that	that	DET
cet-13158	36	8	narrow	narrow	ADJ
cet-13158	36	9	residence	residence	NOUN
cet-13158	36	10	time	time	NOUN
cet-13158	36	11	distributions	distribution	NOUN
cet-13158	36	12	close	close	ADJ
cet-13158	36	13	to	to	ADP
cet-13158	36	14	an	an	DET
cet-13158	36	15	ideal	ideal	ADJ
cet-13158	36	16	plug	plug	NOUN
cet-13158	36	17	flow	flow	NOUN
cet-13158	36	18	are	be	AUX
cet-13158	36	19	achieved	achieve	VERB
cet-13158	36	20	for	for	ADP
cet-13158	36	21	reynolds	reynold	NOUN
cet-13158	36	22	numbers	number	NOUN
cet-13158	36	23	above	above	ADP
cet-13158	36	24	100	100	NUM
cet-13158	36	25	(	(	PUNCT
cet-13158	36	26	schaare	schaare	VERB
cet-13158	36	27	et	et	PROPN
cet-13158	36	28	al	al	PROPN
cet-13158	36	29	.	.	PROPN
cet-13158	36	30	,	,	PUNCT
cet-13158	36	31	2021	2021	NUM
cet-13158	36	32	)	)	PUNCT
cet-13158	36	33	,	,	PUNCT
cet-13158	36	34	providing	provide	VERB
cet-13158	36	35	the	the	DET
cet-13158	36	36	basis	basis	NOUN
cet-13158	36	37	for	for	ADP
cet-13158	36	38	the	the	DET
cet-13158	36	39	kinetic	kinetic	ADJ
cet-13158	36	40	study	study	NOUN
cet-13158	36	41	in	in	ADP
cet-13158	36	42	this	this	DET
cet-13158	36	43	work	work	NOUN
cet-13158	36	44	.	.	PUNCT
cet-13158	37	1	2.2	2.2	NUM
cet-13158	37	2	reaction	reaction	NOUN
cet-13158	37	3	system	system	NOUN
cet-13158	37	4	in	in	ADP
cet-13158	37	5	order	order	NOUN
cet-13158	37	6	to	to	PART
cet-13158	37	7	analyse	analyse	VERB
cet-13158	37	8	the	the	DET
cet-13158	37	9	proposed	propose	VERB
cet-13158	37	10	combination	combination	NOUN
cet-13158	37	11	of	of	ADP
cet-13158	37	12	the	the	DET
cet-13158	37	13	milli	milli	ADJ
cet-13158	37	14	-	-	PUNCT
cet-13158	37	15	structured	structured	ADJ
cet-13158	37	16	plate	plate	NOUN
cet-13158	37	17	reactor	reactor	NOUN
cet-13158	37	18	and	and	CCONJ
cet-13158	37	19	mbdoe	mbdoe	NOUN
cet-13158	37	20	,	,	PUNCT
cet-13158	37	21	kinetic	kinetic	ADJ
cet-13158	37	22	studies	study	NOUN
cet-13158	37	23	are	be	AUX
cet-13158	37	24	performed	perform	VERB
cet-13158	37	25	in	in	ADP
cet-13158	37	26	the	the	DET
cet-13158	37	27	art	art	NOUN
cet-13158	37	28	pr37	pr37	PROPN
cet-13158	37	29	for	for	ADP
cet-13158	37	30	the	the	DET
cet-13158	37	31	nucleophilic	nucleophilic	ADJ
cet-13158	37	32	aromatic	aromatic	ADJ
cet-13158	37	33	substitution	substitution	NOUN
cet-13158	37	34	reaction	reaction	NOUN
cet-13158	37	35	(	(	PUNCT
cet-13158	37	36	snar	snar	PROPN
cet-13158	37	37	reaction	reaction	NOUN
cet-13158	37	38	)	)	PUNCT
cet-13158	37	39	between	between	ADP
cet-13158	37	40	2,4difluoronitrobenzene	2,4difluoronitrobenzene	PROPN
cet-13158	37	41	(	(	PUNCT
cet-13158	37	42	component	component	NOUN
cet-13158	37	43	1	1	NUM
cet-13158	37	44	)	)	PUNCT
cet-13158	37	45	with	with	ADP
cet-13158	37	46	pyrrolidine	pyrrolidine	ADJ
cet-13158	37	47	(	(	PUNCT
cet-13158	37	48	component	component	NOUN
cet-13158	37	49	2	2	NUM
cet-13158	37	50	)	)	PUNCT
cet-13158	37	51	in	in	ADP
cet-13158	37	52	ethanol	ethanol	NOUN
cet-13158	37	53	.	.	PUNCT
cet-13158	38	1	this	this	DET
cet-13158	38	2	multistep	multistep	ADJ
cet-13158	38	3	reaction	reaction	NOUN
cet-13158	38	4	consists	consist	VERB
cet-13158	38	5	of	of	ADP
cet-13158	38	6	two	two	NUM
cet-13158	38	7	parallel	parallel	ADJ
cet-13158	38	8	and	and	CCONJ
cet-13158	38	9	consecutive	consecutive	ADJ
cet-13158	38	10	reactions	reaction	NOUN
cet-13158	38	11	.	.	PUNCT
cet-13158	39	1	the	the	DET
cet-13158	39	2	reaction	reaction	NOUN
cet-13158	39	3	scheme	scheme	NOUN
cet-13158	39	4	is	be	AUX
cet-13158	39	5	shown	show	VERB
cet-13158	39	6	in	in	ADP
cet-13158	39	7	figure	figure	NOUN
cet-13158	39	8	1	1	NUM
cet-13158	39	9	.	.	PUNCT
cet-13158	39	10	figure	figure	NOUN
cet-13158	39	11	1	1	NUM
cet-13158	39	12	:	:	PUNCT
cet-13158	39	13	nucleophilic	nucleophilic	ADJ
cet-13158	39	14	aromatic	aromatic	ADJ
cet-13158	39	15	substitution	substitution	NOUN
cet-13158	39	16	reaction	reaction	NOUN
cet-13158	39	17	of	of	ADP
cet-13158	39	18	2,4	2,4	NUM
cet-13158	39	19	-	-	PUNCT
cet-13158	39	20	difluoronitrobenzene	difluoronitrobenzene	NOUN
cet-13158	39	21	(	(	PUNCT
cet-13158	39	22	1	1	NUM
cet-13158	39	23	)	)	PUNCT
cet-13158	39	24	with	with	ADP
cet-13158	39	25	pyrrolidine	pyrrolidine	ADJ
cet-13158	39	26	(	(	PUNCT
cet-13158	39	27	2	2	NUM
cet-13158	39	28	)	)	PUNCT
cet-13158	39	29	.	.	PUNCT
cet-13158	40	1	during	during	ADP
cet-13158	40	2	the	the	DET
cet-13158	40	3	reaction	reaction	NOUN
cet-13158	40	4	,	,	PUNCT
cet-13158	40	5	the	the	DET
cet-13158	40	6	fluorine	fluorine	NOUN
cet-13158	40	7	atoms	atom	NOUN
cet-13158	40	8	of	of	ADP
cet-13158	40	9	the	the	DET
cet-13158	40	10	2,4	2,4	NUM
cet-13158	40	11	-	-	PUNCT
cet-13158	40	12	diflouronitrobenzene	diflouronitrobenzene	NOUN
cet-13158	40	13	(	(	PUNCT
cet-13158	40	14	1	1	X
cet-13158	40	15	)	)	PUNCT
cet-13158	40	16	are	be	AUX
cet-13158	40	17	substituted	substitute	VERB
cet-13158	40	18	by	by	ADP
cet-13158	40	19	pyrrolidine	pyrrolidine	NOUN
cet-13158	40	20	(	(	PUNCT
cet-13158	40	21	2	2	NUM
cet-13158	40	22	)	)	PUNCT
cet-13158	40	23	forming	form	VERB
cet-13158	40	24	hydrogen	hydrogen	NOUN
cet-13158	40	25	fluoride	fluoride	NOUN
cet-13158	40	26	as	as	ADP
cet-13158	40	27	side	side	NOUN
cet-13158	40	28	product	product	NOUN
cet-13158	40	29	.	.	PUNCT
cet-13158	41	1	in	in	ADP
cet-13158	41	2	the	the	DET
cet-13158	41	3	first	first	ADJ
cet-13158	41	4	substitution	substitution	NOUN
cet-13158	41	5	steps	step	NOUN
cet-13158	41	6	,	,	PUNCT
cet-13158	41	7	ortho(3	ortho(3	PROPN
cet-13158	41	8	)	)	PUNCT
cet-13158	41	9	and	and	CCONJ
cet-13158	41	10	para	para	NOUN
cet-13158	41	11	-	-	PUNCT
cet-13158	41	12	substituted	substitute	VERB
cet-13158	41	13	(	(	PUNCT
cet-13158	41	14	4	4	NUM
cet-13158	41	15	)	)	PUNCT
cet-13158	41	16	intermediates	intermediate	NOUN
cet-13158	41	17	are	be	AUX
cet-13158	41	18	formed	form	VERB
cet-13158	41	19	,	,	PUNCT
cet-13158	41	20	which	which	PRON
cet-13158	41	21	react	react	VERB
cet-13158	41	22	in	in	ADP
cet-13158	41	23	another	another	DET
cet-13158	41	24	substitution	substitution	NOUN
cet-13158	41	25	of	of	ADP
cet-13158	41	26	pyrrolidine	pyrrolidine	NOUN
cet-13158	41	27	to	to	ADP
cet-13158	41	28	the	the	DET
cet-13158	41	29	final	final	ADJ
cet-13158	41	30	bi	bi	ADJ
cet-13158	41	31	-	-	ADJ
cet-13158	41	32	substituted	substitute	VERB
cet-13158	41	33	product	product	NOUN
cet-13158	41	34	(	(	PUNCT
cet-13158	41	35	5	5	NUM
cet-13158	41	36	)	)	PUNCT
cet-13158	41	37	.	.	PUNCT
cet-13158	42	1	according	accord	VERB
cet-13158	42	2	to	to	ADP
cet-13158	42	3	the	the	DET
cet-13158	42	4	kinetic	kinetic	ADJ
cet-13158	42	5	investigations	investigation	NOUN
cet-13158	42	6	of	of	ADP
cet-13158	42	7	hone	hone	NOUN
cet-13158	42	8	et	et	PROPN
cet-13158	42	9	al	al	PROPN
cet-13158	42	10	.	.	PROPN
cet-13158	43	1	(	(	PUNCT
cet-13158	43	2	2017	2017	NUM
cet-13158	43	3	)	)	PUNCT
cet-13158	43	4	,	,	PUNCT
cet-13158	43	5	all	all	DET
cet-13158	43	6	four	four	NUM
cet-13158	43	7	reaction	reaction	NOUN
cet-13158	43	8	steps	step	NOUN
cet-13158	43	9	of	of	ADP
cet-13158	43	10	the	the	DET
cet-13158	43	11	snar	snar	PROPN
cet-13158	43	12	reaction	reaction	NOUN
cet-13158	43	13	can	can	AUX
cet-13158	43	14	be	be	AUX
cet-13158	43	15	assumed	assume	VERB
cet-13158	43	16	as	as	ADP
cet-13158	43	17	second	second	ADJ
cet-13158	43	18	order	order	NOUN
cet-13158	43	19	kinetics	kinetic	NOUN
cet-13158	43	20	.	.	PUNCT
cet-13158	44	1	based	base	VERB
cet-13158	44	2	on	on	ADP
cet-13158	44	3	the	the	DET
cet-13158	44	4	previous	previous	ADJ
cet-13158	44	5	characterization	characterization	NOUN
cet-13158	44	6	of	of	ADP
cet-13158	44	7	the	the	DET
cet-13158	44	8	art	art	NOUN
cet-13158	44	9	reactor	reactor	NOUN
cet-13158	44	10	(	(	PUNCT
cet-13158	44	11	rave	rave	NOUN
cet-13158	44	12	et	et	PROPN
cet-13158	44	13	al	al	PROPN
cet-13158	44	14	.	.	PROPN
cet-13158	44	15	,	,	PUNCT
cet-13158	44	16	476	476	NUM
cet-13158	44	17	2022	2022	NUM
cet-13158	44	18	)	)	PUNCT
cet-13158	44	19	,	,	PUNCT
cet-13158	44	20	an	an	DET
cet-13158	44	21	ideal	ideal	ADJ
cet-13158	44	22	plug	plug	NOUN
cet-13158	44	23	flow	flow	NOUN
cet-13158	44	24	can	can	AUX
cet-13158	44	25	be	be	AUX
cet-13158	44	26	assumed	assume	VERB
cet-13158	44	27	for	for	ADP
cet-13158	44	28	the	the	DET
cet-13158	44	29	reactor	reactor	NOUN
cet-13158	44	30	in	in	ADP
cet-13158	44	31	the	the	DET
cet-13158	44	32	considered	consider	VERB
cet-13158	44	33	operating	operating	NOUN
cet-13158	44	34	window	window	NOUN
cet-13158	44	35	allowing	allow	VERB
cet-13158	44	36	for	for	ADP
cet-13158	44	37	a	a	DET
cet-13158	44	38	direct	direct	ADJ
cet-13158	44	39	modelling	modelling	NOUN
cet-13158	44	40	of	of	ADP
cet-13158	44	41	the	the	DET
cet-13158	44	42	reaction	reaction	NOUN
cet-13158	44	43	kinetics	kinetic	NOUN
cet-13158	44	44	.	.	PUNCT
cet-13158	45	1	the	the	DET
cet-13158	45	2	two	two	NUM
cet-13158	45	3	reactants	reactant	NOUN
cet-13158	45	4	2,4	2,4	NUM
cet-13158	45	5	-	-	PUNCT
cet-13158	45	6	difluoronitrobenzene	difluoronitrobenzene	NOUN
cet-13158	45	7	(	(	PUNCT
cet-13158	45	8	99	99	NUM
cet-13158	45	9	%	%	NOUN
cet-13158	45	10	)	)	PUNCT
cet-13158	45	11	and	and	CCONJ
cet-13158	45	12	pyrrolidine	pyrrolidine	NOUN
cet-13158	45	13	(	(	PUNCT
cet-13158	45	14	99	99	NUM
cet-13158	45	15	%	%	NOUN
cet-13158	45	16	)	)	PUNCT
cet-13158	45	17	are	be	AUX
cet-13158	45	18	purchased	purchase	VERB
cet-13158	45	19	from	from	ADP
cet-13158	45	20	sigma	sigma	PROPN
cet-13158	45	21	-	-	PUNCT
cet-13158	45	22	aldrich	aldrich	PROPN
cet-13158	45	23	as	as	ADV
cet-13158	45	24	well	well	ADV
cet-13158	45	25	as	as	ADP
cet-13158	45	26	the	the	DET
cet-13158	45	27	base	base	NOUN
cet-13158	45	28	triethylamine	triethylamine	NOUN
cet-13158	45	29	(	(	PUNCT
cet-13158	45	30	99,5	99,5	NUM
cet-13158	45	31	%	%	NOUN
cet-13158	45	32	)	)	PUNCT
cet-13158	45	33	and	and	CCONJ
cet-13158	45	34	the	the	DET
cet-13158	45	35	internal	internal	ADJ
cet-13158	45	36	standard	standard	NOUN
cet-13158	45	37	for	for	ADP
cet-13158	45	38	the	the	DET
cet-13158	45	39	hplc	hplc	NOUN
cet-13158	45	40	-	-	PUNCT
cet-13158	45	41	analysis	analysis	NOUN
cet-13158	45	42	n	n	CCONJ
cet-13158	45	43	,	,	PUNCT
cet-13158	45	44	n	n	CCONJ
cet-13158	45	45	-	-	PUNCT
cet-13158	45	46	dimethylbenzamide	dimethylbenzamide	NOUN
cet-13158	45	47	(	(	PUNCT
cet-13158	45	48	99	99	NUM
cet-13158	45	49	%	%	NOUN
cet-13158	45	50	)	)	PUNCT
cet-13158	45	51	.	.	PUNCT
cet-13158	46	1	the	the	DET
cet-13158	46	2	solvent	solvent	NOUN
cet-13158	46	3	ethanol	ethanol	NOUN
cet-13158	46	4	(	(	PUNCT
cet-13158	46	5	99,8	99,8	NUM
cet-13158	46	6	%	%	NOUN
cet-13158	46	7	,	,	PUNCT
cet-13158	46	8	denatured	denature	VERB
cet-13158	46	9	)	)	PUNCT
cet-13158	46	10	and	and	CCONJ
cet-13158	46	11	hydrochloric	hydrochloric	ADJ
cet-13158	46	12	acid	acid	NOUN
cet-13158	46	13	(	(	PUNCT
cet-13158	46	14	1	1	NUM
cet-13158	46	15	n	n	PRON
cet-13158	46	16	standard	standard	ADJ
cet-13158	46	17	solution	solution	NOUN
cet-13158	46	18	)	)	PUNCT
cet-13158	46	19	,	,	PUNCT
cet-13158	46	20	which	which	PRON
cet-13158	46	21	is	be	AUX
cet-13158	46	22	used	use	VERB
cet-13158	46	23	as	as	ADP
cet-13158	46	24	quench	quench	NOUN
cet-13158	46	25	,	,	PUNCT
cet-13158	46	26	are	be	AUX
cet-13158	46	27	purchased	purchase	VERB
cet-13158	46	28	by	by	ADP
cet-13158	46	29	carl	carl	PROPN
cet-13158	46	30	roth	roth	PROPN
cet-13158	46	31	.	.	PUNCT
cet-13158	47	1	2.3	2.3	NUM
cet-13158	47	2	experimental	experimental	ADJ
cet-13158	47	3	setup	setup	NOUN
cet-13158	47	4	and	and	CCONJ
cet-13158	47	5	procedure	procedure	NOUN
cet-13158	47	6	the	the	DET
cet-13158	47	7	experimental	experimental	ADJ
cet-13158	47	8	set	set	VERB
cet-13158	47	9	up	up	ADP
cet-13158	47	10	of	of	ADP
cet-13158	47	11	the	the	DET
cet-13158	47	12	art	art	NOUN
cet-13158	47	13	pr37	pr37	PROPN
cet-13158	47	14	for	for	ADP
cet-13158	47	15	the	the	DET
cet-13158	47	16	kinetic	kinetic	ADJ
cet-13158	47	17	studies	study	NOUN
cet-13158	47	18	is	be	AUX
cet-13158	47	19	divided	divide	VERB
cet-13158	47	20	into	into	ADP
cet-13158	47	21	a	a	DET
cet-13158	47	22	reaction	reaction	NOUN
cet-13158	47	23	and	and	CCONJ
cet-13158	47	24	a	a	DET
cet-13158	47	25	cooling	cool	VERB
cet-13158	47	26	sequence	sequence	NOUN
cet-13158	47	27	.	.	PUNCT
cet-13158	48	1	the	the	DET
cet-13158	48	2	reaction	reaction	NOUN
cet-13158	48	3	sequence	sequence	NOUN
cet-13158	48	4	consists	consist	VERB
cet-13158	48	5	of	of	ADP
cet-13158	48	6	a	a	DET
cet-13158	48	7	series	series	NOUN
cet-13158	48	8	connection	connection	NOUN
cet-13158	48	9	between	between	ADP
cet-13158	48	10	plate	plate	NOUN
cet-13158	48	11	pl37	pl37	PROPN
cet-13158	48	12	-	-	PUNCT
cet-13158	48	13	3	3	NUM
cet-13158	48	14	and	and	CCONJ
cet-13158	48	15	pl37	pl37	PROPN
cet-13158	48	16	-	-	PUNCT
cet-13158	48	17	6	6	NUM
cet-13158	48	18	resulting	result	VERB
cet-13158	48	19	in	in	ADP
cet-13158	48	20	a	a	DET
cet-13158	48	21	reaction	reaction	NOUN
cet-13158	48	22	volume	volume	NOUN
cet-13158	48	23	of	of	ADP
cet-13158	48	24	approximately	approximately	ADV
cet-13158	48	25	40	40	NUM
cet-13158	48	26	ml	ml	NOUN
cet-13158	48	27	.	.	PUNCT
cet-13158	49	1	below	below	ADP
cet-13158	49	2	these	these	DET
cet-13158	49	3	two	two	NUM
cet-13158	49	4	plates	plate	NOUN
cet-13158	49	5	an	an	DET
cet-13158	49	6	insulation	insulation	NOUN
cet-13158	49	7	plate	plate	NOUN
cet-13158	49	8	is	be	AUX
cet-13158	49	9	installed	instal	VERB
cet-13158	49	10	.	.	PUNCT
cet-13158	50	1	this	this	DET
cet-13158	50	2	insulation	insulation	NOUN
cet-13158	50	3	plate	plate	NOUN
cet-13158	50	4	separates	separate	VERB
cet-13158	50	5	the	the	DET
cet-13158	50	6	reaction	reaction	NOUN
cet-13158	50	7	plates	plate	NOUN
cet-13158	50	8	from	from	ADP
cet-13158	50	9	an	an	DET
cet-13158	50	10	additional	additional	ADJ
cet-13158	50	11	plate	plate	NOUN
cet-13158	50	12	pl37	pl37	PROPN
cet-13158	50	13	-	-	PUNCT
cet-13158	50	14	3	3	NUM
cet-13158	50	15	which	which	PRON
cet-13158	50	16	is	be	AUX
cet-13158	50	17	used	use	VERB
cet-13158	50	18	as	as	ADP
cet-13158	50	19	cooling	cool	VERB
cet-13158	50	20	plate	plate	NOUN
cet-13158	50	21	in	in	ADP
cet-13158	50	22	order	order	NOUN
cet-13158	50	23	to	to	PART
cet-13158	50	24	quench	quench	VERB
cet-13158	50	25	the	the	DET
cet-13158	50	26	reaction	reaction	NOUN
cet-13158	50	27	.	.	PUNCT
cet-13158	51	1	with	with	ADP
cet-13158	51	2	the	the	DET
cet-13158	51	3	help	help	NOUN
cet-13158	51	4	of	of	ADP
cet-13158	51	5	the	the	DET
cet-13158	51	6	insulation	insulation	NOUN
cet-13158	51	7	plate	plate	NOUN
cet-13158	51	8	,	,	PUNCT
cet-13158	51	9	two	two	NUM
cet-13158	51	10	thermally	thermally	ADV
cet-13158	51	11	-	-	PUNCT
cet-13158	51	12	decoupled	decouple	VERB
cet-13158	51	13	zones	zone	NOUN
cet-13158	51	14	are	be	AUX
cet-13158	51	15	realized	realize	VERB
cet-13158	51	16	.	.	PUNCT
cet-13158	52	1	the	the	DET
cet-13158	52	2	schematic	schematic	ADJ
cet-13158	52	3	setup	setup	NOUN
cet-13158	52	4	of	of	ADP
cet-13158	52	5	the	the	DET
cet-13158	52	6	pilot	pilot	NOUN
cet-13158	52	7	plant	plant	NOUN
cet-13158	52	8	is	be	AUX
cet-13158	52	9	shown	show	VERB
cet-13158	52	10	in	in	ADP
cet-13158	52	11	figure	figure	NOUN
cet-13158	52	12	2	2	NUM
cet-13158	52	13	.	.	PUNCT
cet-13158	52	14	figure	figure	NOUN
cet-13158	52	15	2	2	NUM
cet-13158	52	16	:	:	PUNCT
cet-13158	52	17	schematic	schematic	ADJ
cet-13158	52	18	scheme	scheme	NOUN
cet-13158	52	19	from	from	ADP
cet-13158	52	20	the	the	DET
cet-13158	52	21	pilot	pilot	NOUN
cet-13158	52	22	plant	plant	NOUN
cet-13158	52	23	of	of	ADP
cet-13158	52	24	the	the	DET
cet-13158	52	25	art	art	NOUN
cet-13158	52	26	plate	plate	NOUN
cet-13158	52	27	reactor	reactor	NOUN
cet-13158	52	28	pr37	pr37	PROPN
cet-13158	52	29	.	.	PUNCT
cet-13158	53	1	the	the	DET
cet-13158	53	2	two	two	NUM
cet-13158	53	3	reactant	reactant	NOUN
cet-13158	53	4	solutions	solution	NOUN
cet-13158	53	5	,	,	PUNCT
cet-13158	53	6	introduced	introduce	VERB
cet-13158	53	7	in	in	ADP
cet-13158	53	8	section	section	NOUN
cet-13158	53	9	2.2	2.2	NUM
cet-13158	53	10	,	,	PUNCT
cet-13158	53	11	are	be	AUX
cet-13158	53	12	fed	feed	VERB
cet-13158	53	13	into	into	ADP
cet-13158	53	14	the	the	DET
cet-13158	53	15	reactor	reactor	NOUN
cet-13158	53	16	using	use	VERB
cet-13158	53	17	gear	gear	NOUN
cet-13158	53	18	pumps	pump	NOUN
cet-13158	53	19	.	.	PUNCT
cet-13158	54	1	the	the	DET
cet-13158	54	2	mass	mass	ADJ
cet-13158	54	3	flow	flow	NOUN
cet-13158	54	4	and	and	CCONJ
cet-13158	54	5	density	density	NOUN
cet-13158	54	6	of	of	ADP
cet-13158	54	7	the	the	DET
cet-13158	54	8	streams	stream	NOUN
cet-13158	54	9	are	be	AUX
cet-13158	54	10	measured	measure	VERB
cet-13158	54	11	using	use	VERB
cet-13158	54	12	a	a	DET
cet-13158	54	13	coriolis	corioli	NOUN
cet-13158	54	14	mass	mass	NOUN
cet-13158	54	15	flow	flow	NOUN
cet-13158	54	16	meter	meter	NOUN
cet-13158	54	17	.	.	PUNCT
cet-13158	55	1	the	the	DET
cet-13158	55	2	utility	utility	NOUN
cet-13158	55	3	for	for	ADP
cet-13158	55	4	the	the	DET
cet-13158	55	5	reaction	reaction	NOUN
cet-13158	55	6	sequence	sequence	NOUN
cet-13158	55	7	is	be	AUX
cet-13158	55	8	controlled	control	VERB
cet-13158	55	9	by	by	ADP
cet-13158	55	10	a	a	DET
cet-13158	55	11	heating	heating	NOUN
cet-13158	55	12	circulator	circulator	NOUN
cet-13158	55	13	supplied	supply	VERB
cet-13158	55	14	with	with	ADP
cet-13158	55	15	thermal	thermal	ADJ
cet-13158	55	16	oil	oil	NOUN
cet-13158	55	17	.	.	PUNCT
cet-13158	56	1	a	a	DET
cet-13158	56	2	centrifugal	centrifugal	ADJ
cet-13158	56	3	pump	pump	NOUN
cet-13158	56	4	is	be	AUX
cet-13158	56	5	used	use	VERB
cet-13158	56	6	to	to	PART
cet-13158	56	7	enhance	enhance	VERB
cet-13158	56	8	the	the	DET
cet-13158	56	9	utility	utility	NOUN
cet-13158	56	10	flow	flow	NOUN
cet-13158	56	11	rates	rate	NOUN
cet-13158	56	12	for	for	ADP
cet-13158	56	13	an	an	DET
cet-13158	56	14	improved	improved	ADJ
cet-13158	56	15	heat	heat	NOUN
cet-13158	56	16	transfer	transfer	NOUN
cet-13158	56	17	.	.	PUNCT
cet-13158	57	1	the	the	DET
cet-13158	57	2	utility	utility	NOUN
cet-13158	57	3	stream	stream	NOUN
cet-13158	57	4	for	for	ADP
cet-13158	57	5	the	the	DET
cet-13158	57	6	cooling	cool	VERB
cet-13158	57	7	plate	plate	NOUN
cet-13158	57	8	is	be	AUX
cet-13158	57	9	supplied	supply	VERB
cet-13158	57	10	with	with	ADP
cet-13158	57	11	tap	tap	NOUN
cet-13158	57	12	water	water	NOUN
cet-13158	57	13	with	with	ADP
cet-13158	57	14	a	a	DET
cet-13158	57	15	temperature	temperature	NOUN
cet-13158	57	16	of	of	ADP
cet-13158	57	17	approximately	approximately	ADV
cet-13158	57	18	16	16	NUM
cet-13158	57	19	°	°	NOUN
cet-13158	57	20	c	c	NOUN
cet-13158	57	21	.	.	PUNCT
cet-13158	58	1	in	in	ADP
cet-13158	58	2	this	this	DET
cet-13158	58	3	way	way	NOUN
cet-13158	58	4	an	an	DET
cet-13158	58	5	efficient	efficient	ADJ
cet-13158	58	6	thermal	thermal	ADJ
cet-13158	58	7	quench	quench	NOUN
cet-13158	58	8	of	of	ADP
cet-13158	58	9	the	the	DET
cet-13158	58	10	reaction	reaction	NOUN
cet-13158	58	11	is	be	AUX
cet-13158	58	12	achieved	achieve	VERB
cet-13158	58	13	in	in	ADP
cet-13158	58	14	the	the	DET
cet-13158	58	15	thermally	thermally	ADV
cet-13158	58	16	-	-	PUNCT
cet-13158	58	17	decoupled	decouple	VERB
cet-13158	58	18	cooling	cool	VERB
cet-13158	58	19	plate	plate	NOUN
cet-13158	58	20	after	after	ADP
cet-13158	58	21	the	the	DET
cet-13158	58	22	two	two	NUM
cet-13158	58	23	reaction	reaction	NOUN
cet-13158	58	24	plates	plate	NOUN
cet-13158	58	25	.	.	PUNCT
cet-13158	59	1	additionally	additionally	ADV
cet-13158	59	2	,	,	PUNCT
cet-13158	59	3	a	a	DET
cet-13158	59	4	back	back	ADJ
cet-13158	59	5	-	-	PUNCT
cet-13158	59	6	pressure	pressure	NOUN
cet-13158	59	7	regulator	regulator	NOUN
cet-13158	59	8	is	be	AUX
cet-13158	59	9	used	use	VERB
cet-13158	59	10	at	at	ADP
cet-13158	59	11	the	the	DET
cet-13158	59	12	reactor	reactor	NOUN
cet-13158	59	13	outlet	outlet	NOUN
cet-13158	59	14	allowing	allow	VERB
cet-13158	59	15	to	to	PART
cet-13158	59	16	keep	keep	VERB
cet-13158	59	17	ethanol	ethanol	NOUN
cet-13158	59	18	,	,	PUNCT
cet-13158	59	19	which	which	PRON
cet-13158	59	20	is	be	AUX
cet-13158	59	21	used	use	VERB
cet-13158	59	22	as	as	ADP
cet-13158	59	23	solvent	solvent	NOUN
cet-13158	59	24	,	,	PUNCT
cet-13158	59	25	in	in	ADP
cet-13158	59	26	liquid	liquid	ADJ
cet-13158	59	27	state	state	NOUN
cet-13158	59	28	at	at	ADP
cet-13158	59	29	temperatures	temperature	NOUN
cet-13158	59	30	above	above	ADP
cet-13158	59	31	boiling	boiling	NOUN
cet-13158	59	32	point	point	NOUN
cet-13158	59	33	.	.	PUNCT
cet-13158	60	1	the	the	DET
cet-13158	60	2	process	process	NOUN
cet-13158	60	3	and	and	CCONJ
cet-13158	60	4	utility	utility	NOUN
cet-13158	60	5	channels	channel	NOUN
cet-13158	60	6	are	be	AUX
cet-13158	60	7	equipped	equip	VERB
cet-13158	60	8	in	in	ADP
cet-13158	60	9	total	total	NOUN
cet-13158	60	10	with	with	ADP
cet-13158	60	11	12	12	NUM
cet-13158	60	12	thermocouples	thermocouple	NOUN
cet-13158	60	13	.	.	PUNCT
cet-13158	61	1	all	all	DET
cet-13158	61	2	measured	measured	ADJ
cet-13158	61	3	values	value	NOUN
cet-13158	61	4	are	be	AUX
cet-13158	61	5	continuously	continuously	ADV
cet-13158	61	6	monitored	monitor	VERB
cet-13158	61	7	on	on	ADP
cet-13158	61	8	a	a	DET
cet-13158	61	9	computer	computer	NOUN
cet-13158	61	10	using	use	VERB
cet-13158	61	11	fieldpoint	fieldpoint	NOUN
cet-13158	61	12	modules	module	NOUN
cet-13158	61	13	and	and	CCONJ
cet-13158	61	14	labview	labview	NOUN
cet-13158	61	15	providing	provide	VERB
cet-13158	61	16	a	a	DET
cet-13158	61	17	full	full	ADJ
cet-13158	61	18	insight	insight	NOUN
cet-13158	61	19	into	into	ADP
cet-13158	61	20	the	the	DET
cet-13158	61	21	process	process	NOUN
cet-13158	61	22	.	.	PUNCT
cet-13158	62	1	the	the	DET
cet-13158	62	2	sampling	sampling	NOUN
cet-13158	62	3	is	be	AUX
cet-13158	62	4	done	do	VERB
cet-13158	62	5	at	at	ADP
cet-13158	62	6	the	the	DET
cet-13158	62	7	outlet	outlet	NOUN
cet-13158	62	8	of	of	ADP
cet-13158	62	9	the	the	DET
cet-13158	62	10	cooling	cool	VERB
cet-13158	62	11	plate	plate	NOUN
cet-13158	62	12	with	with	ADP
cet-13158	62	13	hplc	hplc	NOUN
cet-13158	62	14	vials	vial	NOUN
cet-13158	62	15	and	and	CCONJ
cet-13158	62	16	an	an	DET
cet-13158	62	17	additional	additional	ADJ
cet-13158	62	18	chemical	chemical	NOUN
cet-13158	62	19	quench	quench	NOUN
cet-13158	62	20	with	with	ADP
cet-13158	62	21	hydrochloric	hydrochloric	ADJ
cet-13158	62	22	acid	acid	NOUN
cet-13158	62	23	.	.	PUNCT
cet-13158	63	1	the	the	DET
cet-13158	63	2	experiments	experiment	NOUN
cet-13158	63	3	are	be	AUX
cet-13158	63	4	conducted	conduct	VERB
cet-13158	63	5	according	accord	VERB
cet-13158	63	6	to	to	ADP
cet-13158	63	7	two	two	NUM
cet-13158	63	8	different	different	ADJ
cet-13158	63	9	experimental	experimental	ADJ
cet-13158	63	10	plans	plan	NOUN
cet-13158	63	11	.	.	PUNCT
cet-13158	64	1	three	three	NUM
cet-13158	64	2	factors	factor	NOUN
cet-13158	64	3	are	be	AUX
cet-13158	64	4	varied	varied	ADJ
cet-13158	64	5	in	in	ADP
cet-13158	64	6	the	the	DET
cet-13158	64	7	experiments	experiment	NOUN
cet-13158	64	8	:	:	PUNCT
cet-13158	64	9	temperature	temperature	NOUN
cet-13158	64	10	,	,	PUNCT
cet-13158	64	11	pyrrolidine	pyrrolidine	ADJ
cet-13158	64	12	concentration	concentration	NOUN
cet-13158	64	13	and	and	CCONJ
cet-13158	64	14	residence	residence	NOUN
cet-13158	64	15	time	time	NOUN
cet-13158	64	16	.	.	PUNCT
cet-13158	65	1	the	the	DET
cet-13158	65	2	concentrations	concentration	NOUN
cet-13158	65	3	of	of	ADP
cet-13158	65	4	2,4difluoronitrobenzene	2,4difluoronitrobenzene	PROPN
cet-13158	65	5	is	be	AUX
cet-13158	65	6	kept	keep	VERB
cet-13158	65	7	constant	constant	ADJ
cet-13158	65	8	as	as	ADV
cet-13158	65	9	well	well	ADV
cet-13158	65	10	as	as	ADP
cet-13158	65	11	the	the	DET
cet-13158	65	12	concentration	concentration	NOUN
cet-13158	65	13	of	of	ADP
cet-13158	65	14	triethylamine	triethylamine	NOUN
cet-13158	65	15	and	and	CCONJ
cet-13158	65	16	the	the	DET
cet-13158	65	17	internal	internal	ADJ
cet-13158	65	18	standard	standard	PROPN
cet-13158	65	19	n	n	CCONJ
cet-13158	65	20	,	,	PUNCT
cet-13158	65	21	n	n	CCONJ
cet-13158	65	22	-	-	PUNCT
cet-13158	65	23	dimethylbenzamide	dimethylbenzamide	NOUN
cet-13158	65	24	.	.	PUNCT
cet-13158	66	1	in	in	ADP
cet-13158	66	2	the	the	DET
cet-13158	66	3	first	first	ADJ
cet-13158	66	4	set	set	NOUN
cet-13158	66	5	of	of	ADP
cet-13158	66	6	experiments	experiment	NOUN
cet-13158	66	7	,	,	PUNCT
cet-13158	66	8	a	a	DET
cet-13158	66	9	face	face	NOUN
cet-13158	66	10	-	-	PUNCT
cet-13158	66	11	centered	center	VERB
cet-13158	66	12	central	central	ADJ
cet-13158	66	13	composite	composite	NOUN
cet-13158	66	14	(	(	PUNCT
cet-13158	66	15	ccf	ccf	PROPN
cet-13158	66	16	)	)	PUNCT
cet-13158	66	17	design	design	NOUN
cet-13158	66	18	of	of	ADP
cet-13158	66	19	these	these	DET
cet-13158	66	20	three	three	NUM
cet-13158	66	21	factors	factor	NOUN
cet-13158	66	22	is	be	AUX
cet-13158	66	23	used	use	VERB
cet-13158	66	24	.	.	PUNCT
cet-13158	67	1	the	the	DET
cet-13158	67	2	temperature	temperature	NOUN
cet-13158	67	3	for	for	ADP
cet-13158	67	4	this	this	DET
cet-13158	67	5	design	design	NOUN
cet-13158	67	6	plan	plan	NOUN
cet-13158	67	7	is	be	AUX
cet-13158	67	8	set	set	VERB
cet-13158	67	9	between	between	ADP
cet-13158	67	10	50	50	NUM
cet-13158	67	11	,	,	PUNCT
cet-13158	67	12	75	75	NUM
cet-13158	67	13	and	and	CCONJ
cet-13158	67	14	100	100	NUM
cet-13158	67	15	°	°	NOUN
cet-13158	67	16	c	c	NOUN
cet-13158	67	17	.	.	PUNCT
cet-13158	68	1	the	the	DET
cet-13158	68	2	pyrrolidine	pyrrolidine	ADJ
cet-13158	68	3	concentration	concentration	NOUN
cet-13158	68	4	is	be	AUX
cet-13158	68	5	varied	vary	VERB
cet-13158	68	6	between	between	ADP
cet-13158	68	7	0.05	0.05	NUM
cet-13158	68	8	,	,	PUNCT
cet-13158	68	9	0.25	0.25	NUM
cet-13158	68	10	and	and	CCONJ
cet-13158	68	11	0.5	0.5	NUM
cet-13158	68	12	m.	m.	NOUN
cet-13158	68	13	the	the	DET
cet-13158	68	14	minimum	minimum	ADJ
cet-13158	68	15	residence	residence	NOUN
cet-13158	68	16	time	time	NOUN
cet-13158	68	17	is	be	AUX
cet-13158	68	18	0.5	0.5	NUM
cet-13158	68	19	min	min	NOUN
cet-13158	68	20	.	.	PUNCT
cet-13158	69	1	the	the	DET
cet-13158	69	2	maximum	maximum	ADJ
cet-13158	69	3	residence	residence	NOUN
cet-13158	69	4	time	time	NOUN
cet-13158	69	5	depends	depend	VERB
cet-13158	69	6	on	on	ADP
cet-13158	69	7	the	the	DET
cet-13158	69	8	minimum	minimum	NOUN
cet-13158	69	9	required	require	VERB
cet-13158	69	10	reynolds	reynold	NOUN
cet-13158	69	11	number	number	NOUN
cet-13158	69	12	of	of	ADP
cet-13158	69	13	100	100	NUM
cet-13158	69	14	allowing	allow	VERB
cet-13158	69	15	an	an	DET
cet-13158	69	16	ideal	ideal	ADJ
cet-13158	69	17	plug	plug	NOUN
cet-13158	69	18	flow	flow	NOUN
cet-13158	69	19	to	to	PART
cet-13158	69	20	be	be	AUX
cet-13158	69	21	assumed	assume	VERB
cet-13158	69	22	in	in	ADP
cet-13158	69	23	the	the	DET
cet-13158	69	24	art	art	NOUN
cet-13158	69	25	reactor	reactor	NOUN
cet-13158	69	26	,	,	PUNCT
cet-13158	69	27	which	which	PRON
cet-13158	69	28	means	mean	VERB
cet-13158	69	29	that	that	SCONJ
cet-13158	69	30	the	the	DET
cet-13158	69	31	maximum	maximum	ADJ
cet-13158	69	32	residence	residence	NOUN
cet-13158	69	33	time	time	NOUN
cet-13158	69	34	depends	depend	VERB
cet-13158	69	35	on	on	ADP
cet-13158	69	36	the	the	DET
cet-13158	69	37	density	density	NOUN
cet-13158	69	38	and	and	CCONJ
cet-13158	69	39	the	the	DET
cet-13158	69	40	operating	operating	NOUN
cet-13158	69	41	temperature	temperature	NOUN
cet-13158	69	42	,	,	PUNCT
cet-13158	69	43	respectively	respectively	ADV
cet-13158	69	44	.	.	PUNCT
cet-13158	70	1	therefore	therefore	ADV
cet-13158	70	2	,	,	PUNCT
cet-13158	70	3	the	the	DET
cet-13158	70	4	maximum	maximum	ADJ
cet-13158	70	5	residence	residence	NOUN
cet-13158	70	6	time	time	NOUN
cet-13158	70	7	is	be	AUX
cet-13158	70	8	identified	identify	VERB
cet-13158	70	9	individually	individually	ADV
cet-13158	70	10	by	by	ADP
cet-13158	70	11	means	mean	NOUN
cet-13158	70	12	of	of	ADP
cet-13158	70	13	the	the	DET
cet-13158	70	14	developed	develop	VERB
cet-13158	70	15	correlation	correlation	NOUN
cet-13158	70	16	for	for	ADP
cet-13158	70	17	the	the	DET
cet-13158	70	18	residence	residence	NOUN
cet-13158	70	19	time	time	NOUN
cet-13158	70	20	distribution	distribution	NOUN
cet-13158	70	21	(	(	PUNCT
cet-13158	70	22	schaare	schaare	VERB
cet-13158	70	23	et	et	PROPN
cet-13158	70	24	al	al	PROPN
cet-13158	70	25	.	.	PROPN
cet-13158	70	26	,	,	PUNCT
cet-13158	70	27	2021	2021	NUM
cet-13158	70	28	)	)	PUNCT
cet-13158	70	29	and	and	CCONJ
cet-13158	70	30	ranges	range	NOUN
cet-13158	70	31	between	between	ADP
cet-13158	70	32	2	2	NUM
cet-13158	70	33	and	and	CCONJ
cet-13158	70	34	3	3	NUM
cet-13158	70	35	min	min	NOUN
cet-13158	70	36	.	.	PUNCT
cet-13158	71	1	the	the	DET
cet-13158	71	2	ccf	ccf	PROPN
cet-13158	71	3	design	design	NOUN
cet-13158	71	4	plan	plan	NOUN
cet-13158	71	5	consists	consist	VERB
cet-13158	71	6	of	of	ADP
cet-13158	71	7	15	15	NUM
cet-13158	71	8	experiments	experiment	NOUN
cet-13158	71	9	in	in	ADP
cet-13158	71	10	total	total	NOUN
cet-13158	71	11	.	.	PUNCT
cet-13158	72	1	in	in	ADP
cet-13158	72	2	the	the	DET
cet-13158	72	3	second	second	ADJ
cet-13158	72	4	set	set	NOUN
cet-13158	72	5	of	of	ADP
cet-13158	72	6	experiments	experiment	NOUN
cet-13158	72	7	,	,	PUNCT
cet-13158	72	8	a	a	DET
cet-13158	72	9	mbdoe	mbdoe	NOUN
cet-13158	72	10	is	be	AUX
cet-13158	72	11	applied	apply	VERB
cet-13158	72	12	based	base	VERB
cet-13158	72	13	on	on	ADP
cet-13158	72	14	four	four	NUM
cet-13158	72	15	initial	initial	ADJ
cet-13158	72	16	experiments	experiment	NOUN
cet-13158	72	17	from	from	ADP
cet-13158	72	18	the	the	DET
cet-13158	72	19	ccf	ccf	PROPN
cet-13158	72	20	design	design	NOUN
cet-13158	72	21	plan	plan	NOUN
cet-13158	72	22	.	.	PUNCT
cet-13158	73	1	the	the	DET
cet-13158	73	2	subsequent	subsequent	ADJ
cet-13158	73	3	experiments	experiment	NOUN
cet-13158	73	4	are	be	AUX
cet-13158	73	5	determined	determine	VERB
cet-13158	73	6	in	in	ADP
cet-13158	73	7	an	an	DET
cet-13158	73	8	iterative	iterative	NOUN
cet-13158	73	9	mbdoe	mbdoe	NOUN
cet-13158	73	10	approach	approach	NOUN
cet-13158	73	11	with	with	ADP
cet-13158	73	12	successive	successive	ADJ
cet-13158	73	13	refinement	refinement	NOUN
cet-13158	73	14	of	of	ADP
cet-13158	73	15	the	the	DET
cet-13158	73	16	kinetic	kinetic	ADJ
cet-13158	73	17	parameters	parameter	NOUN
cet-13158	73	18	after	after	ADP
cet-13158	73	19	each	each	DET
cet-13158	73	20	experiment	experiment	NOUN
cet-13158	73	21	,	,	PUNCT
cet-13158	73	22	due	due	ADP
cet-13158	73	23	to	to	ADP
cet-13158	73	24	the	the	DET
cet-13158	73	25	nonlinearity	nonlinearity	NOUN
cet-13158	73	26	of	of	ADP
cet-13158	73	27	the	the	DET
cet-13158	73	28	reaction	reaction	NOUN
cet-13158	73	29	kinetic	kinetic	NOUN
cet-13158	73	30	model	model	NOUN
cet-13158	73	31	.	.	PUNCT
cet-13158	74	1	the	the	DET
cet-13158	74	2	initial	initial	ADJ
cet-13158	74	3	set	set	NOUN
cet-13158	74	4	of	of	ADP
cet-13158	74	5	experiments	experiment	NOUN
cet-13158	74	6	includes	include	VERB
cet-13158	74	7	two	two	NUM
cet-13158	74	8	experiments	experiment	NOUN
cet-13158	74	9	under	under	ADP
cet-13158	74	10	moderate	moderate	ADJ
cet-13158	74	11	conditions	condition	NOUN
cet-13158	74	12	at	at	ADP
cet-13158	74	13	low	low	ADJ
cet-13158	74	14	concentration	concentration	NOUN
cet-13158	74	15	and	and	CCONJ
cet-13158	74	16	temperature	temperature	NOUN
cet-13158	74	17	and	and	CCONJ
cet-13158	74	18	two	two	NUM
cet-13158	74	19	experiments	experiment	NOUN
cet-13158	74	20	under	under	ADP
cet-13158	74	21	extreme	extreme	ADJ
cet-13158	74	22	conditions	condition	NOUN
cet-13158	74	23	at	at	ADP
cet-13158	74	24	high	high	ADJ
cet-13158	74	25	concentration	concentration	NOUN
cet-13158	74	26	and	and	CCONJ
cet-13158	74	27	temperature	temperature	NOUN
cet-13158	74	28	.	.	PUNCT
cet-13158	75	1	p1n2	p1n2	NOUN
cet-13158	75	2	p2n2	p2n2	NOUN
cet-13158	75	3	n3	n3	PROPN
cet-13158	75	4	n4	n4	PROPN
cet-13158	75	5	n5	n5	PROPN
cet-13158	75	6	n6	n6	PROPN
cet-13158	75	7	n7	n7	PROPN
cet-13158	75	8	n8	n8	PROPN
cet-13158	75	9	p2n2	p2n2	PROPN
cet-13158	75	10	n3	n3	PROPN
cet-13158	75	11	n4	n4	PROPN
cet-13158	75	12	n5	n5	PROPN
cet-13158	75	13	n6	n6	PROPN
cet-13158	75	14	n7	n7	PROPN
cet-13158	75	15	n8	n8	PROPN
cet-13158	75	16	p2n2	p2n2	PROPN
cet-13158	75	17	n3	n3	PROPN
cet-13158	75	18	n4	n4	PROPN
cet-13158	75	19	n5	n5	PROPN
cet-13158	75	20	n6	n6	PROPN
cet-13158	75	21	n7	n7	PROPN
cet-13158	75	22	n8	n8	PROPN
cet-13158	75	23	p1n2	p1n2	PROPN
cet-13158	75	24	tir	tir	PROPN
cet-13158	75	25	tir	tir	X
cet-13158	75	26	…	…	X
cet-13158	75	27	tir	tir	PROPN
cet-13158	75	28	pir	pir	PROPN
cet-13158	75	29	pir	pir	PROPN
cet-13158	75	30	tir	tir	PROPN
cet-13158	75	31	tir	tir	PROPN
cet-13158	75	32	fir	fir	PROPN
cet-13158	75	33	pir	pir	PROPN
cet-13158	75	34	fir	fir	PROPN
cet-13158	75	35	bpr	bpr	PROPN
cet-13158	75	36	477	477	NUM
cet-13158	75	37	subsequent	subsequent	ADJ
cet-13158	75	38	experimental	experimental	ADJ
cet-13158	75	39	conditions	condition	NOUN
cet-13158	75	40	are	be	AUX
cet-13158	75	41	determined	determine	VERB
cet-13158	75	42	by	by	ADP
cet-13158	75	43	the	the	DET
cet-13158	75	44	mbdoe	mbdoe	NOUN
cet-13158	75	45	considering	consider	VERB
cet-13158	75	46	the	the	DET
cet-13158	75	47	d	d	ADJ
cet-13158	75	48	-	-	ADJ
cet-13158	75	49	optimal	optimal	ADJ
cet-13158	75	50	criteria	criterion	NOUN
cet-13158	75	51	.	.	PUNCT
cet-13158	76	1	after	after	ADP
cet-13158	76	2	each	each	DET
cet-13158	76	3	additional	additional	ADJ
cet-13158	76	4	experiment	experiment	NOUN
cet-13158	76	5	,	,	PUNCT
cet-13158	76	6	a	a	DET
cet-13158	76	7	nonlinear	nonlinear	ADJ
cet-13158	76	8	regression	regression	NOUN
cet-13158	76	9	is	be	AUX
cet-13158	76	10	performed	perform	VERB
cet-13158	76	11	to	to	PART
cet-13158	76	12	update	update	VERB
cet-13158	76	13	the	the	DET
cet-13158	76	14	parameter	parameter	NOUN
cet-13158	76	15	estimates	estimate	NOUN
cet-13158	76	16	,	,	PUNCT
cet-13158	76	17	before	before	ADP
cet-13158	76	18	repeating	repeat	VERB
cet-13158	76	19	the	the	DET
cet-13158	76	20	cycle	cycle	NOUN
cet-13158	76	21	again	again	ADV
cet-13158	76	22	,	,	PUNCT
cet-13158	76	23	until	until	SCONJ
cet-13158	76	24	a	a	DET
cet-13158	76	25	satisfactory	satisfactory	ADJ
cet-13158	76	26	parameter	parameter	NOUN
cet-13158	76	27	accuracy	accuracy	NOUN
cet-13158	76	28	is	be	AUX
cet-13158	76	29	achieved	achieve	VERB
cet-13158	76	30	.	.	PUNCT
cet-13158	77	1	the	the	DET
cet-13158	77	2	latter	latter	ADJ
cet-13158	77	3	is	be	AUX
cet-13158	77	4	quantified	quantify	VERB
cet-13158	77	5	by	by	ADP
cet-13158	77	6	the	the	DET
cet-13158	77	7	95	95	NUM
cet-13158	77	8	%	%	NOUN
cet-13158	77	9	confidence	confidence	NOUN
cet-13158	77	10	intervals	interval	NOUN
cet-13158	77	11	of	of	ADP
cet-13158	77	12	the	the	DET
cet-13158	77	13	respective	respective	ADJ
cet-13158	77	14	parameters	parameter	NOUN
cet-13158	77	15	.	.	PUNCT
cet-13158	78	1	the	the	DET
cet-13158	78	2	experiments	experiment	NOUN
cet-13158	78	3	designed	design	VERB
cet-13158	78	4	based	base	VERB
cet-13158	78	5	on	on	ADP
cet-13158	78	6	this	this	DET
cet-13158	78	7	method	method	NOUN
cet-13158	78	8	are	be	AUX
cet-13158	78	9	described	describe	VERB
cet-13158	78	10	in	in	ADP
cet-13158	78	11	detail	detail	NOUN
cet-13158	78	12	in	in	ADP
cet-13158	78	13	section	section	NOUN
cet-13158	78	14	3.2	3.2	NUM
cet-13158	78	15	.	.	PUNCT
cet-13158	79	1	3	3	X
cet-13158	79	2	.	.	NOUN
cet-13158	79	3	results	result	NOUN
cet-13158	79	4	and	and	CCONJ
cet-13158	79	5	discussion	discussion	NOUN
cet-13158	79	6	3.1	3.1	NUM
cet-13158	79	7	factorial	factorial	NOUN
cet-13158	79	8	design	design	NOUN
cet-13158	79	9	of	of	ADP
cet-13158	79	10	experiments	experiment	NOUN
cet-13158	79	11	the	the	DET
cet-13158	79	12	experimental	experimental	ADJ
cet-13158	79	13	data	datum	NOUN
cet-13158	79	14	of	of	ADP
cet-13158	79	15	the	the	DET
cet-13158	79	16	ccf	ccf	PROPN
cet-13158	79	17	design	design	NOUN
cet-13158	79	18	plan	plan	NOUN
cet-13158	79	19	is	be	AUX
cet-13158	79	20	fitted	fit	VERB
cet-13158	79	21	to	to	ADP
cet-13158	79	22	the	the	DET
cet-13158	79	23	kinetic	kinetic	ADJ
cet-13158	79	24	parameter	parameter	NOUN
cet-13158	79	25	of	of	ADP
cet-13158	79	26	the	the	DET
cet-13158	79	27	reaction	reaction	NOUN
cet-13158	79	28	scheme	scheme	NOUN
cet-13158	79	29	shown	show	VERB
cet-13158	79	30	in	in	ADP
cet-13158	79	31	figure	figure	NOUN
cet-13158	79	32	1	1	NUM
cet-13158	79	33	.	.	PUNCT
cet-13158	80	1	the	the	DET
cet-13158	80	2	nonlinear	nonlinear	ADJ
cet-13158	80	3	regression	regression	NOUN
cet-13158	80	4	is	be	AUX
cet-13158	80	5	performed	perform	VERB
cet-13158	80	6	as	as	ADP
cet-13158	80	7	non	non	ADJ
cet-13158	80	8	-	-	ADJ
cet-13158	80	9	linear	linear	ADJ
cet-13158	80	10	curve	curve	NOUN
cet-13158	80	11	-	-	PUNCT
cet-13158	80	12	fitting	fit	VERB
cet-13158	80	13	problem	problem	NOUN
cet-13158	80	14	using	use	VERB
cet-13158	80	15	lsqcurvefit	lsqcurvefit	NOUN
cet-13158	80	16	in	in	ADP
cet-13158	80	17	matlab	matlab	PROPN
cet-13158	80	18	,	,	PUNCT
cet-13158	80	19	with	with	ADP
cet-13158	80	20	the	the	DET
cet-13158	80	21	trust	trust	NOUN
cet-13158	80	22	-	-	PUNCT
cet-13158	80	23	region	region	NOUN
cet-13158	80	24	-	-	PUNCT
cet-13158	80	25	reflective	reflective	ADJ
cet-13158	80	26	algorithm	algorithm	NOUN
cet-13158	80	27	.	.	PUNCT
cet-13158	81	1	the	the	DET
cet-13158	81	2	estimated	estimate	VERB
cet-13158	81	3	rate	rate	NOUN
cet-13158	81	4	constants	constant	NOUN
cet-13158	81	5	and	and	CCONJ
cet-13158	81	6	the	the	DET
cet-13158	81	7	corresponding	corresponding	ADJ
cet-13158	81	8	95	95	NUM
cet-13158	81	9	%	%	NOUN
cet-13158	81	10	confidence	confidence	NOUN
cet-13158	81	11	intervals	interval	NOUN
cet-13158	81	12	based	base	VERB
cet-13158	81	13	on	on	ADP
cet-13158	81	14	the	the	DET
cet-13158	81	15	experiments	experiment	NOUN
cet-13158	81	16	from	from	ADP
cet-13158	81	17	the	the	DET
cet-13158	81	18	doe	doe	NOUN
cet-13158	81	19	are	be	AUX
cet-13158	81	20	given	give	VERB
cet-13158	81	21	in	in	ADP
cet-13158	81	22	table	table	NOUN
cet-13158	81	23	1	1	NUM
cet-13158	81	24	.	.	PUNCT
cet-13158	81	25	table	table	NOUN
cet-13158	81	26	1	1	NUM
cet-13158	81	27	:	:	PUNCT
cet-13158	81	28	kinetic	kinetic	ADJ
cet-13158	81	29	parameter	parameter	NOUN
cet-13158	81	30	estimation	estimation	NOUN
cet-13158	81	31	for	for	ADP
cet-13158	81	32	the	the	DET
cet-13158	81	33	factorial	factorial	ADJ
cet-13158	81	34	design	design	NOUN
cet-13158	81	35	plan	plan	NOUN
cet-13158	81	36	rate	rate	NOUN
cet-13158	81	37	step	step	NOUN
cet-13158	81	38	k0	k0	PROPN
cet-13158	81	39	[	[	X
cet-13158	81	40	l	l	NOUN
cet-13158	81	41	/	/	SYM
cet-13158	81	42	mol	mol	PROPN
cet-13158	81	43	/	/	SYM
cet-13158	81	44	s	s	PART
cet-13158	81	45	]	]	PUNCT
cet-13158	81	46	ea	ea	NOUN
cet-13158	82	1	[	[	X
cet-13158	82	2	kj	kj	PROPN
cet-13158	82	3	/	/	SYM
cet-13158	82	4	mol	mol	NOUN
cet-13158	82	5	]	]	SYM
cet-13158	82	6	1	1	NUM
cet-13158	82	7	0.158	0.158	NUM
cet-13158	82	8	±	±	NUM
cet-13158	82	9	5	5	NUM
cet-13158	82	10	%	%	NOUN
cet-13158	82	11	49.5	49.5	NUM
cet-13158	82	12	±	±	NUM
cet-13158	82	13	5.3	5.3	NUM
cet-13158	82	14	%	%	NOUN
cet-13158	82	15	2	2	NUM
cet-13158	82	16	0.0242	0.0242	NUM
cet-13158	82	17	±	±	NUM
cet-13158	82	18	14	14	NUM
cet-13158	82	19	%	%	NOUN
cet-13158	82	20	48.9	48.9	NUM
cet-13158	82	21	±	±	NUM
cet-13158	82	22	11	11	NUM
cet-13158	82	23	%	%	NOUN
cet-13158	82	24	3	3	NUM
cet-13158	82	25	1.55·10	1.55·10	NUM
cet-13158	82	26	-	-	SYM
cet-13158	82	27	6	6	NUM
cet-13158	82	28	±	±	NOUN
cet-13158	82	29	6900	6900	NUM
cet-13158	82	30	%	%	NOUN
cet-13158	82	31	76.2	76.2	NUM
cet-13158	82	32	±	±	NOUN
cet-13158	82	33	2100	2100	NUM
cet-13158	82	34	%	%	NOUN
cet-13158	82	35	4	4	NUM
cet-13158	82	36	4.36·10	4.36·10	NUM
cet-13158	82	37	-	-	SYM
cet-13158	82	38	4	4	NUM
cet-13158	82	39	±	±	NUM
cet-13158	82	40	370	370	NUM
cet-13158	82	41	%	%	NOUN
cet-13158	82	42	62.6	62.6	NUM
cet-13158	82	43	±	±	NUM
cet-13158	82	44	140	140	NUM
cet-13158	82	45	%	%	NOUN
cet-13158	82	46	the	the	DET
cet-13158	82	47	kinetic	kinetic	ADJ
cet-13158	82	48	parameters	parameter	NOUN
cet-13158	82	49	for	for	ADP
cet-13158	82	50	the	the	DET
cet-13158	82	51	first	first	ADJ
cet-13158	82	52	two	two	NUM
cet-13158	82	53	rate	rate	NOUN
cet-13158	82	54	steps	step	NOUN
cet-13158	82	55	are	be	AUX
cet-13158	82	56	estimated	estimate	VERB
cet-13158	82	57	with	with	ADP
cet-13158	82	58	a	a	DET
cet-13158	82	59	high	high	ADJ
cet-13158	82	60	accuracy	accuracy	NOUN
cet-13158	82	61	and	and	CCONJ
cet-13158	82	62	confidence	confidence	NOUN
cet-13158	82	63	intervals	interval	NOUN
cet-13158	82	64	below	below	ADP
cet-13158	82	65	15	15	NUM
cet-13158	82	66	%	%	NOUN
cet-13158	82	67	.	.	PUNCT
cet-13158	83	1	it	it	PRON
cet-13158	83	2	is	be	AUX
cet-13158	83	3	noticeable	noticeable	ADJ
cet-13158	83	4	that	that	SCONJ
cet-13158	83	5	the	the	DET
cet-13158	83	6	rate	rate	NOUN
cet-13158	83	7	constant	constant	ADJ
cet-13158	83	8	for	for	ADP
cet-13158	83	9	reaction	reaction	NOUN
cet-13158	83	10	step	step	NOUN
cet-13158	83	11	1	1	NUM
cet-13158	83	12	is	be	AUX
cet-13158	83	13	significantly	significantly	ADV
cet-13158	83	14	higher	high	ADJ
cet-13158	83	15	than	than	ADP
cet-13158	83	16	for	for	ADP
cet-13158	83	17	step	step	NOUN
cet-13158	83	18	2	2	NUM
cet-13158	83	19	,	,	PUNCT
cet-13158	83	20	while	while	SCONJ
cet-13158	83	21	the	the	DET
cet-13158	83	22	activation	activation	NOUN
cet-13158	83	23	energies	energy	NOUN
cet-13158	83	24	are	be	AUX
cet-13158	83	25	approximately	approximately	ADV
cet-13158	83	26	the	the	DET
cet-13158	83	27	same	same	ADJ
cet-13158	83	28	.	.	PUNCT
cet-13158	84	1	this	this	PRON
cet-13158	84	2	implies	imply	VERB
cet-13158	84	3	that	that	PRON
cet-13158	84	4	component	component	NOUN
cet-13158	84	5	3	3	NUM
cet-13158	84	6	is	be	AUX
cet-13158	84	7	formed	form	VERB
cet-13158	84	8	significantly	significantly	ADV
cet-13158	84	9	faster	fast	ADV
cet-13158	84	10	than	than	ADP
cet-13158	84	11	component	component	NOUN
cet-13158	84	12	4	4	NUM
cet-13158	84	13	.	.	PUNCT
cet-13158	85	1	unlike	unlike	ADP
cet-13158	85	2	the	the	DET
cet-13158	85	3	first	first	ADJ
cet-13158	85	4	two	two	NUM
cet-13158	85	5	rate	rate	NOUN
cet-13158	85	6	steps	step	NOUN
cet-13158	85	7	,	,	PUNCT
cet-13158	85	8	the	the	DET
cet-13158	85	9	kinetic	kinetic	ADJ
cet-13158	85	10	parameters	parameter	NOUN
cet-13158	85	11	of	of	ADP
cet-13158	85	12	the	the	DET
cet-13158	85	13	two	two	NUM
cet-13158	85	14	consecutive	consecutive	ADJ
cet-13158	85	15	reactions	reaction	NOUN
cet-13158	85	16	to	to	PART
cet-13158	85	17	form	form	VERB
cet-13158	85	18	the	the	DET
cet-13158	85	19	bi	bi	ADJ
cet-13158	85	20	-	-	ADJ
cet-13158	85	21	substituted	substitute	VERB
cet-13158	85	22	product	product	NOUN
cet-13158	85	23	are	be	AUX
cet-13158	85	24	practically	practically	ADV
cet-13158	85	25	not	not	PART
cet-13158	85	26	identifiable	identifiable	ADJ
cet-13158	85	27	,	,	PUNCT
cet-13158	85	28	indicated	indicate	VERB
cet-13158	85	29	by	by	ADP
cet-13158	85	30	the	the	DET
cet-13158	85	31	large	large	ADJ
cet-13158	85	32	confidence	confidence	NOUN
cet-13158	85	33	intervals	interval	NOUN
cet-13158	85	34	.	.	PUNCT
cet-13158	86	1	in	in	ADP
cet-13158	86	2	order	order	NOUN
cet-13158	86	3	to	to	PART
cet-13158	86	4	analyze	analyze	VERB
cet-13158	86	5	the	the	DET
cet-13158	86	6	kinetic	kinetic	ADJ
cet-13158	86	7	parameter	parameter	NOUN
cet-13158	86	8	estimation	estimation	NOUN
cet-13158	86	9	in	in	ADP
cet-13158	86	10	more	more	ADJ
cet-13158	86	11	detail	detail	NOUN
cet-13158	86	12	,	,	PUNCT
cet-13158	86	13	figure	figure	NOUN
cet-13158	86	14	3	3	NUM
cet-13158	86	15	(	(	PUNCT
cet-13158	86	16	a	a	NOUN
cet-13158	86	17	)	)	PUNCT
cet-13158	86	18	shows	show	VERB
cet-13158	86	19	the	the	DET
cet-13158	86	20	molar	molar	ADJ
cet-13158	86	21	composition	composition	NOUN
cet-13158	86	22	of	of	ADP
cet-13158	86	23	the	the	DET
cet-13158	86	24	outlet	outlet	NOUN
cet-13158	86	25	concentration	concentration	NOUN
cet-13158	86	26	for	for	ADP
cet-13158	86	27	the	the	DET
cet-13158	86	28	experiments	experiment	NOUN
cet-13158	86	29	in	in	ADP
cet-13158	86	30	dependency	dependency	NOUN
cet-13158	86	31	of	of	ADP
cet-13158	86	32	the	the	DET
cet-13158	86	33	damköhler	damköhler	NOUN
cet-13158	86	34	number	number	NOUN
cet-13158	86	35	da	da	PROPN
cet-13158	86	36	.	.	PUNCT
cet-13158	87	1	the	the	DET
cet-13158	87	2	damköhler	damköhler	NOUN
cet-13158	87	3	number	number	NOUN
cet-13158	87	4	is	be	AUX
cet-13158	87	5	a	a	DET
cet-13158	87	6	function	function	NOUN
cet-13158	87	7	of	of	ADP
cet-13158	87	8	the	the	DET
cet-13158	87	9	input	input	NOUN
cet-13158	87	10	design	design	NOUN
cet-13158	87	11	parameters	parameter	NOUN
cet-13158	87	12	and	and	CCONJ
cet-13158	87	13	represents	represent	VERB
cet-13158	87	14	a	a	DET
cet-13158	87	15	measure	measure	NOUN
cet-13158	87	16	for	for	ADP
cet-13158	87	17	the	the	DET
cet-13158	87	18	relative	relative	ADJ
cet-13158	87	19	reactivity	reactivity	NOUN
cet-13158	87	20	.	.	PUNCT
cet-13158	88	1	figure	figure	VERB
cet-13158	88	2	3	3	NUM
cet-13158	88	3	:	:	PUNCT
cet-13158	88	4	(	(	PUNCT
cet-13158	88	5	a	a	X
cet-13158	88	6	)	)	PUNCT
cet-13158	88	7	molar	molar	ADJ
cet-13158	88	8	composition	composition	NOUN
cet-13158	88	9	for	for	ADP
cet-13158	88	10	the	the	DET
cet-13158	88	11	reactor	reactor	NOUN
cet-13158	88	12	outlet	outlet	NOUN
cet-13158	88	13	concentration	concentration	NOUN
cet-13158	88	14	of	of	ADP
cet-13158	88	15	component	component	NOUN
cet-13158	88	16	(	(	PUNCT
cet-13158	88	17	1	1	NUM
cet-13158	88	18	)	)	PUNCT
cet-13158	88	19	,	,	PUNCT
cet-13158	88	20	(	(	PUNCT
cet-13158	88	21	3	3	NUM
cet-13158	88	22	)	)	PUNCT
cet-13158	88	23	,	,	PUNCT
cet-13158	88	24	(	(	PUNCT
cet-13158	88	25	4	4	NUM
cet-13158	88	26	)	)	PUNCT
cet-13158	88	27	and	and	CCONJ
cet-13158	88	28	(	(	PUNCT
cet-13158	88	29	5	5	NUM
cet-13158	88	30	)	)	PUNCT
cet-13158	88	31	as	as	ADP
cet-13158	88	32	function	function	NOUN
cet-13158	88	33	of	of	ADP
cet-13158	88	34	the	the	DET
cet-13158	88	35	damköhler	damköhler	NOUN
cet-13158	88	36	number	number	NOUN
cet-13158	88	37	and	and	CCONJ
cet-13158	88	38	(	(	PUNCT
cet-13158	88	39	b	b	NOUN
cet-13158	88	40	)	)	PUNCT
cet-13158	88	41	parity	parity	NOUN
cet-13158	88	42	plot	plot	NOUN
cet-13158	88	43	showing	show	VERB
cet-13158	88	44	experimental	experimental	ADJ
cet-13158	88	45	vs.	vs.	ADP
cet-13158	88	46	modelled	model	VERB
cet-13158	88	47	molar	molar	ADJ
cet-13158	88	48	composition	composition	NOUN
cet-13158	88	49	.	.	PUNCT
cet-13158	89	1	figure	figure	NOUN
cet-13158	89	2	3	3	NUM
cet-13158	89	3	(	(	PUNCT
cet-13158	89	4	a	a	NOUN
cet-13158	89	5	)	)	PUNCT
cet-13158	89	6	shows	show	VERB
cet-13158	89	7	that	that	SCONJ
cet-13158	89	8	component	component	NOUN
cet-13158	89	9	3	3	NUM
cet-13158	89	10	is	be	AUX
cet-13158	89	11	formed	form	VERB
cet-13158	89	12	in	in	ADP
cet-13158	89	13	excess	excess	NOUN
cet-13158	89	14	compared	compare	VERB
cet-13158	89	15	to	to	PART
cet-13158	89	16	component	component	VERB
cet-13158	89	17	4	4	NUM
cet-13158	89	18	reaching	reach	VERB
cet-13158	89	19	a	a	DET
cet-13158	89	20	maximum	maximum	ADJ
cet-13158	89	21	selectivity	selectivity	NOUN
cet-13158	89	22	of	of	ADP
cet-13158	89	23	about	about	ADV
cet-13158	89	24	90	90	NUM
cet-13158	89	25	%	%	NOUN
cet-13158	89	26	at	at	ADP
cet-13158	89	27	low	low	ADJ
cet-13158	89	28	da	da	PROPN
cet-13158	89	29	.	.	PUNCT
cet-13158	90	1	this	this	PRON
cet-13158	90	2	confirms	confirm	VERB
cet-13158	90	3	the	the	DET
cet-13158	90	4	estimated	estimate	VERB
cet-13158	90	5	rate	rate	NOUN
cet-13158	90	6	constants	constant	NOUN
cet-13158	90	7	for	for	ADP
cet-13158	90	8	step	step	NOUN
cet-13158	90	9	1	1	NUM
cet-13158	90	10	and	and	CCONJ
cet-13158	90	11	2	2	NUM
cet-13158	90	12	.	.	NOUN
cet-13158	90	13	while	while	SCONJ
cet-13158	90	14	the	the	DET
cet-13158	90	15	molar	molar	ADJ
cet-13158	90	16	composition	composition	NOUN
cet-13158	90	17	of	of	ADP
cet-13158	90	18	component	component	NOUN
cet-13158	90	19	3	3	NUM
cet-13158	90	20	remains	remain	VERB
cet-13158	90	21	approximately	approximately	ADV
cet-13158	90	22	constant	constant	ADJ
cet-13158	90	23	with	with	ADP
cet-13158	90	24	increasing	increase	VERB
cet-13158	90	25	da	da	NOUN
cet-13158	90	26	,	,	PUNCT
cet-13158	90	27	component	component	NOUN
cet-13158	90	28	4	4	NUM
cet-13158	90	29	is	be	AUX
cet-13158	90	30	reduced	reduce	VERB
cet-13158	90	31	under	under	ADP
cet-13158	90	32	extreme	extreme	ADJ
cet-13158	90	33	conditions	condition	NOUN
cet-13158	90	34	resulting	result	VERB
cet-13158	90	35	in	in	ADP
cet-13158	90	36	a	a	DET
cet-13158	90	37	formation	formation	NOUN
cet-13158	90	38	of	of	ADP
cet-13158	90	39	component	component	NOUN
cet-13158	90	40	5	5	NUM
cet-13158	90	41	.	.	PUNCT
cet-13158	91	1	this	this	PRON
cet-13158	91	2	indicates	indicate	VERB
cet-13158	91	3	that	that	SCONJ
cet-13158	91	4	rate	rate	NOUN
cet-13158	91	5	step	step	NOUN
cet-13158	91	6	4	4	NUM
cet-13158	91	7	is	be	AUX
cet-13158	91	8	significantly	significantly	ADV
cet-13158	91	9	faster	fast	ADJ
cet-13158	91	10	than	than	ADP
cet-13158	91	11	rate	rate	NOUN
cet-13158	91	12	step	step	NOUN
cet-13158	91	13	3	3	NUM
cet-13158	91	14	which	which	PRON
cet-13158	91	15	is	be	AUX
cet-13158	91	16	negligible	negligible	ADJ
cet-13158	91	17	small	small	ADJ
cet-13158	91	18	under	under	ADP
cet-13158	91	19	the	the	DET
cet-13158	91	20	given	give	VERB
cet-13158	91	21	conditions	condition	NOUN
cet-13158	91	22	.	.	PUNCT
cet-13158	92	1	the	the	DET
cet-13158	92	2	high	high	ADJ
cet-13158	92	3	uncertainties	uncertainty	NOUN
cet-13158	92	4	for	for	ADP
cet-13158	92	5	the	the	DET
cet-13158	92	6	estimation	estimation	NOUN
cet-13158	92	7	of	of	ADP
cet-13158	92	8	these	these	DET
cet-13158	92	9	rate	rate	NOUN
cet-13158	92	10	steps	step	NOUN
cet-13158	92	11	are	be	AUX
cet-13158	92	12	caused	cause	VERB
cet-13158	92	13	by	by	ADP
cet-13158	92	14	the	the	DET
cet-13158	92	15	fact	fact	NOUN
cet-13158	92	16	that	that	SCONJ
cet-13158	92	17	the	the	DET
cet-13158	92	18	formation	formation	NOUN
cet-13158	92	19	of	of	ADP
cet-13158	92	20	component	component	NOUN
cet-13158	92	21	5	5	NUM
cet-13158	92	22	is	be	AUX
cet-13158	92	23	very	very	ADV
cet-13158	92	24	small	small	ADJ
cet-13158	92	25	and	and	CCONJ
cet-13158	92	26	only	only	ADV
cet-13158	92	27	in	in	ADP
cet-13158	92	28	one	one	NUM
cet-13158	92	29	experiment	experiment	NOUN
cet-13158	92	30	at	at	ADP
cet-13158	92	31	the	the	DET
cet-13158	92	32	highest	high	ADJ
cet-13158	92	33	da	da	NOUN
cet-13158	92	34	a	a	DET
cet-13158	92	35	selectivity	selectivity	NOUN
cet-13158	92	36	of	of	ADP
cet-13158	92	37	close	close	ADJ
cet-13158	92	38	to	to	PART
cet-13158	92	39	10	10	NUM
cet-13158	92	40	%	%	NOUN
cet-13158	92	41	is	be	AUX
cet-13158	92	42	reached	reach	VERB
cet-13158	92	43	.	.	PUNCT
cet-13158	93	1	it	it	PRON
cet-13158	93	2	is	be	AUX
cet-13158	93	3	important	important	ADJ
cet-13158	93	4	to	to	PART
cet-13158	93	5	note	note	VERB
cet-13158	93	6	that	that	SCONJ
cet-13158	93	7	despite	despite	SCONJ
cet-13158	93	8	the	the	DET
cet-13158	93	9	high	high	ADJ
cet-13158	93	10	uncertainty	uncertainty	NOUN
cet-13158	93	11	,	,	PUNCT
cet-13158	93	12	the	the	DET
cet-13158	93	13	model	model	NOUN
cet-13158	93	14	provides	provide	VERB
cet-13158	93	15	a	a	DET
cet-13158	93	16	good	good	ADJ
cet-13158	93	17	approximation	approximation	NOUN
cet-13158	93	18	of	of	ADP
cet-13158	93	19	the	the	DET
cet-13158	93	20	experimental	experimental	ADJ
cet-13158	93	21	values	value	NOUN
cet-13158	93	22	as	as	SCONJ
cet-13158	93	23	indicated	indicate	VERB
cet-13158	93	24	in	in	ADP
cet-13158	93	25	the	the	DET
cet-13158	93	26	parity	parity	NOUN
cet-13158	93	27	plot	plot	NOUN
cet-13158	93	28	in	in	ADP
cet-13158	93	29	figure	figure	NOUN
cet-13158	93	30	3	3	NUM
cet-13158	93	31	(	(	PUNCT
cet-13158	93	32	b	b	NOUN
cet-13158	93	33	)	)	PUNCT
cet-13158	93	34	.	.	PUNCT
cet-13158	94	1	only	only	ADV
cet-13158	94	2	at	at	ADP
cet-13158	94	3	low	low	ADJ
cet-13158	94	4	composition	composition	NOUN
cet-13158	94	5	of	of	ADP
cet-13158	94	6	component	component	NOUN
cet-13158	94	7	1	1	NUM
cet-13158	94	8	noticeable	noticeable	ADJ
cet-13158	94	9	deviations	deviation	NOUN
cet-13158	94	10	above	above	ADP
cet-13158	94	11	the	the	DET
cet-13158	94	12	20	20	NUM
cet-13158	94	13	%	%	NOUN
cet-13158	94	14	lines	line	NOUN
cet-13158	94	15	are	be	AUX
cet-13158	94	16	found	find	VERB
cet-13158	94	17	,	,	PUNCT
cet-13158	94	18	which	which	PRON
cet-13158	94	19	relate	relate	VERB
cet-13158	94	20	to	to	ADP
cet-13158	94	21	higher	high	ADJ
cet-13158	94	22	inaccuracies	inaccuracy	NOUN
cet-13158	94	23	of	of	ADP
cet-13158	94	24	the	the	DET
cet-13158	94	25	hplc	hplc	NOUN
cet-13158	94	26	at	at	ADP
cet-13158	94	27	these	these	DET
cet-13158	94	28	concentrations	concentration	NOUN
cet-13158	94	29	.	.	PUNCT
cet-13158	95	1	however	however	ADV
cet-13158	95	2	,	,	PUNCT
cet-13158	95	3	due	due	ADP
cet-13158	95	4	to	to	ADP
cet-13158	95	5	the	the	DET
cet-13158	95	6	limited	limited	ADJ
cet-13158	95	7	data	datum	NOUN
cet-13158	95	8	on	on	ADP
cet-13158	95	9	the	the	DET
cet-13158	95	10	consecutive	consecutive	ADJ
cet-13158	95	11	reactions	reaction	NOUN
cet-13158	95	12	it	it	PRON
cet-13158	95	13	can	can	AUX
cet-13158	95	14	be	be	AUX
cet-13158	95	15	concluded	conclude	VERB
cet-13158	95	16	that	that	SCONJ
cet-13158	95	17	the	the	DET
cet-13158	95	18	estimated	estimate	VERB
cet-13158	95	19	kinetic	kinetic	ADJ
cet-13158	95	20	model	model	NOUN
cet-13158	95	21	is	be	AUX
cet-13158	95	22	capable	capable	ADJ
cet-13158	95	23	to	to	PART
cet-13158	95	24	accurately	accurately	ADV
cet-13158	95	25	predict	predict	VERB
cet-13158	95	26	the	the	DET
cet-13158	95	27	first	first	ADJ
cet-13158	95	28	two	two	NUM
cet-13158	95	29	rate	rate	NOUN
cet-13158	95	30	steps	step	NOUN
cet-13158	95	31	,	,	PUNCT
cet-13158	95	32	while	while	SCONJ
cet-13158	95	33	the	the	DET
cet-13158	95	34	prediction	prediction	NOUN
cet-13158	95	35	of	of	ADP
cet-13158	95	36	the	the	DET
cet-13158	95	37	consecutive	consecutive	ADJ
cet-13158	95	38	reactions	reaction	NOUN
cet-13158	95	39	is	be	AUX
cet-13158	95	40	highly	highly	ADV
cet-13158	95	41	uncertain	uncertain	ADJ
cet-13158	95	42	,	,	PUNCT
cet-13158	95	43	limiting	limit	VERB
cet-13158	95	44	the	the	DET
cet-13158	95	45	extrapolability	extrapolability	NOUN
cet-13158	95	46	of	of	ADP
cet-13158	95	47	the	the	DET
cet-13158	95	48	model	model	NOUN
cet-13158	95	49	.	.	PUNCT
cet-13158	96	1	therefore	therefore	ADV
cet-13158	96	2	,	,	PUNCT
cet-13158	96	3	in	in	ADP
cet-13158	96	4	the	the	DET
cet-13158	96	5	next	next	ADJ
cet-13158	96	6	step	step	NOUN
cet-13158	96	7	the	the	DET
cet-13158	96	8	design	design	NOUN
cet-13158	96	9	concept	concept	NOUN
cet-13158	96	10	of	of	ADP
cet-13158	96	11	mbdoe	mbdoe	NOUN
cet-13158	96	12	is	be	AUX
cet-13158	96	13	used	use	VERB
cet-13158	96	14	to	to	PART
cet-13158	96	15	improve	improve	VERB
cet-13158	96	16	the	the	DET
cet-13158	96	17	quality	quality	NOUN
cet-13158	96	18	of	of	ADP
cet-13158	96	19	the	the	DET
cet-13158	96	20	kinetic	kinetic	ADJ
cet-13158	96	21	model	model	NOUN
cet-13158	96	22	especially	especially	ADV
cet-13158	96	23	in	in	ADP
cet-13158	96	24	regards	regard	NOUN
cet-13158	96	25	of	of	ADP
cet-13158	96	26	the	the	DET
cet-13158	96	27	consecutive	consecutive	ADJ
cet-13158	96	28	reactions	reaction	NOUN
cet-13158	96	29	.	.	PUNCT
cet-13158	97	1	+20	+20	NUM
cet-13158	97	2	%	%	NOUN
cet-13158	97	3	-20	-20	NUM
cet-13158	97	4	%	%	NOUN
cet-13158	97	5	478	478	NUM
cet-13158	97	6	3.2	3.2	NUM
cet-13158	97	7	model	model	NOUN
cet-13158	97	8	-	-	PUNCT
cet-13158	97	9	based	base	VERB
cet-13158	97	10	design	design	NOUN
cet-13158	97	11	of	of	ADP
cet-13158	97	12	experiments	experiment	NOUN
cet-13158	97	13	based	base	VERB
cet-13158	97	14	on	on	ADP
cet-13158	97	15	the	the	DET
cet-13158	97	16	initial	initial	ADJ
cet-13158	97	17	four	four	NUM
cet-13158	97	18	experiments	experiment	NOUN
cet-13158	97	19	extracted	extract	VERB
cet-13158	97	20	from	from	ADP
cet-13158	97	21	the	the	DET
cet-13158	97	22	ccf	ccf	NOUN
cet-13158	97	23	,	,	PUNCT
cet-13158	97	24	a	a	DET
cet-13158	97	25	first	first	ADJ
cet-13158	97	26	estimation	estimation	NOUN
cet-13158	97	27	of	of	ADP
cet-13158	97	28	the	the	DET
cet-13158	97	29	kinetic	kinetic	ADJ
cet-13158	97	30	parameters	parameter	NOUN
cet-13158	97	31	is	be	AUX
cet-13158	97	32	performed	perform	VERB
cet-13158	97	33	.	.	PUNCT
cet-13158	98	1	next	next	ADJ
cet-13158	98	2	a	a	DET
cet-13158	98	3	d	d	ADJ
cet-13158	98	4	-	-	ADJ
cet-13158	98	5	optimal	optimal	ADJ
cet-13158	98	6	mbdoe	mbdoe	NOUN
cet-13158	98	7	is	be	AUX
cet-13158	98	8	performed	perform	VERB
cet-13158	98	9	in	in	ADP
cet-13158	98	10	order	order	NOUN
cet-13158	98	11	to	to	PART
cet-13158	98	12	find	find	VERB
cet-13158	98	13	the	the	DET
cet-13158	98	14	next	next	ADJ
cet-13158	98	15	best	good	ADJ
cet-13158	98	16	experimental	experimental	ADJ
cet-13158	98	17	conditions	condition	NOUN
cet-13158	98	18	providing	provide	VERB
cet-13158	98	19	a	a	DET
cet-13158	98	20	high	high	ADJ
cet-13158	98	21	level	level	NOUN
cet-13158	98	22	of	of	ADP
cet-13158	98	23	information	information	NOUN
cet-13158	98	24	.	.	PUNCT
cet-13158	99	1	since	since	SCONJ
cet-13158	99	2	the	the	DET
cet-13158	99	3	inlet	inlet	ADJ
cet-13158	99	4	concentration	concentration	NOUN
cet-13158	99	5	can	can	AUX
cet-13158	99	6	not	not	PART
cet-13158	99	7	be	be	AUX
cet-13158	99	8	adjusted	adjust	VERB
cet-13158	99	9	continuously	continuously	ADV
cet-13158	99	10	during	during	ADP
cet-13158	99	11	operation	operation	NOUN
cet-13158	99	12	and	and	CCONJ
cet-13158	99	13	the	the	DET
cet-13158	99	14	feed	feed	NOUN
cet-13158	99	15	solutions	solution	NOUN
cet-13158	99	16	need	need	VERB
cet-13158	99	17	to	to	PART
cet-13158	99	18	be	be	AUX
cet-13158	99	19	prepared	prepare	VERB
cet-13158	99	20	in	in	ADP
cet-13158	99	21	advance	advance	NOUN
cet-13158	99	22	,	,	PUNCT
cet-13158	99	23	only	only	ADV
cet-13158	99	24	residence	residence	NOUN
cet-13158	99	25	time	time	NOUN
cet-13158	99	26	and	and	CCONJ
cet-13158	99	27	temperature	temperature	NOUN
cet-13158	99	28	are	be	AUX
cet-13158	99	29	considered	consider	VERB
cet-13158	99	30	as	as	ADP
cet-13158	99	31	variables	variable	NOUN
cet-13158	99	32	,	,	PUNCT
cet-13158	99	33	determining	determine	VERB
cet-13158	99	34	d	d	ADJ
cet-13158	99	35	-	-	ADJ
cet-13158	99	36	optimal	optimal	ADJ
cet-13158	99	37	experiments	experiment	NOUN
cet-13158	99	38	for	for	ADP
cet-13158	99	39	low	low	ADJ
cet-13158	99	40	concentration	concentration	NOUN
cet-13158	99	41	of	of	ADP
cet-13158	99	42	pyrrolidine	pyrrolidine	NOUN
cet-13158	99	43	at	at	ADP
cet-13158	99	44	0.05	0.05	NUM
cet-13158	99	45	mol	mol	ADP
cet-13158	99	46	/	/	SYM
cet-13158	99	47	l	l	NOUN
cet-13158	99	48	and	and	CCONJ
cet-13158	99	49	at	at	ADP
cet-13158	99	50	high	high	ADJ
cet-13158	99	51	concentration	concentration	NOUN
cet-13158	99	52	of	of	ADP
cet-13158	99	53	0.5	0.5	NUM
cet-13158	99	54	mol	mol	NOUN
cet-13158	99	55	/	/	SYM
cet-13158	99	56	l.	l.	NOUN
cet-13158	99	57	these	these	DET
cet-13158	99	58	two	two	NUM
cet-13158	99	59	respective	respective	ADJ
cet-13158	99	60	experiments	experiment	NOUN
cet-13158	99	61	are	be	AUX
cet-13158	99	62	performed	perform	VERB
cet-13158	99	63	in	in	ADP
cet-13158	99	64	each	each	DET
cet-13158	99	65	mbdoe	mbdoe	NOUN
cet-13158	99	66	iteration	iteration	NOUN
cet-13158	99	67	with	with	ADP
cet-13158	99	68	a	a	DET
cet-13158	99	69	successive	successive	ADJ
cet-13158	99	70	refinement	refinement	NOUN
cet-13158	99	71	of	of	ADP
cet-13158	99	72	the	the	DET
cet-13158	99	73	kinetic	kinetic	ADJ
cet-13158	99	74	parameters	parameter	NOUN
cet-13158	99	75	by	by	ADP
cet-13158	99	76	nonlinear	nonlinear	ADJ
cet-13158	99	77	regression	regression	NOUN
cet-13158	99	78	.	.	PUNCT
cet-13158	100	1	figure	figure	VERB
cet-13158	100	2	4	4	NUM
cet-13158	100	3	:	:	PUNCT
cet-13158	100	4	d	d	ADJ
cet-13158	100	5	-	-	ADJ
cet-13158	100	6	optimal	optimal	ADJ
cet-13158	100	7	design	design	NOUN
cet-13158	100	8	criteria	criterion	NOUN
cet-13158	100	9	determined	determine	VERB
cet-13158	100	10	from	from	ADP
cet-13158	100	11	the	the	DET
cet-13158	100	12	initial	initial	ADJ
cet-13158	100	13	experiments	experiment	NOUN
cet-13158	100	14	as	as	ADP
cet-13158	100	15	function	function	NOUN
cet-13158	100	16	of	of	ADP
cet-13158	100	17	the	the	DET
cet-13158	100	18	residence	residence	NOUN
cet-13158	100	19	time	time	NOUN
cet-13158	100	20	and	and	CCONJ
cet-13158	100	21	the	the	DET
cet-13158	100	22	temperature	temperature	NOUN
cet-13158	100	23	at	at	ADP
cet-13158	100	24	constant	constant	ADJ
cet-13158	100	25	inlet	inlet	NOUN
cet-13158	100	26	concentration	concentration	NOUN
cet-13158	100	27	of	of	ADP
cet-13158	100	28	component	component	NOUN
cet-13158	100	29	(	(	PUNCT
cet-13158	100	30	2	2	NUM
cet-13158	100	31	)	)	PUNCT
cet-13158	100	32	for	for	ADP
cet-13158	100	33	(	(	PUNCT
cet-13158	100	34	a	a	X
cet-13158	100	35	)	)	PUNCT
cet-13158	100	36	0.05	0.05	NUM
cet-13158	100	37	mol	mol	ADP
cet-13158	100	38	/	/	SYM
cet-13158	100	39	l	l	NOUN
cet-13158	100	40	and	and	CCONJ
cet-13158	100	41	(	(	PUNCT
cet-13158	100	42	b	b	NOUN
cet-13158	100	43	)	)	PUNCT
cet-13158	100	44	0.5	0.5	NUM
cet-13158	100	45	mol	mol	PROPN
cet-13158	100	46	/	/	SYM
cet-13158	100	47	l.	l.	PROPN
cet-13158	100	48	figure	figure	NOUN
cet-13158	100	49	4	4	NUM
cet-13158	100	50	exemplarily	exemplarily	ADV
cet-13158	100	51	illustrates	illustrate	VERB
cet-13158	100	52	the	the	DET
cet-13158	100	53	objective	objective	ADJ
cet-13158	100	54	function	function	NOUN
cet-13158	100	55	of	of	ADP
cet-13158	100	56	the	the	DET
cet-13158	100	57	d	d	ADJ
cet-13158	100	58	-	-	ADJ
cet-13158	100	59	optimal	optimal	ADJ
cet-13158	100	60	criterion	criterion	NOUN
cet-13158	100	61	objective	objective	NOUN
cet-13158	100	62	for	for	ADP
cet-13158	100	63	the	the	DET
cet-13158	100	64	first	first	ADJ
cet-13158	100	65	optimally	optimally	ADV
cet-13158	100	66	planned	plan	VERB
cet-13158	100	67	experiment	experiment	NOUN
cet-13158	100	68	,	,	PUNCT
cet-13158	100	69	based	base	VERB
cet-13158	100	70	on	on	ADP
cet-13158	100	71	the	the	DET
cet-13158	100	72	initial	initial	ADJ
cet-13158	100	73	experiments	experiment	NOUN
cet-13158	100	74	,	,	PUNCT
cet-13158	100	75	evaluated	evaluate	VERB
cet-13158	100	76	for	for	ADP
cet-13158	100	77	varying	vary	VERB
cet-13158	100	78	residence	residence	NOUN
cet-13158	100	79	time	time	NOUN
cet-13158	100	80	and	and	CCONJ
cet-13158	100	81	temperature	temperature	NOUN
cet-13158	100	82	for	for	ADP
cet-13158	100	83	(	(	PUNCT
cet-13158	100	84	a	a	PRON
cet-13158	100	85	)	)	PUNCT
cet-13158	100	86	low	low	ADJ
cet-13158	100	87	and	and	CCONJ
cet-13158	100	88	(	(	PUNCT
cet-13158	100	89	b	b	NOUN
cet-13158	100	90	)	)	PUNCT
cet-13158	100	91	high	high	ADJ
cet-13158	100	92	pyrrolidine	pyrrolidine	ADJ
cet-13158	100	93	concentration	concentration	NOUN
cet-13158	100	94	.	.	PUNCT
cet-13158	101	1	for	for	ADP
cet-13158	101	2	low	low	ADJ
cet-13158	101	3	pyrrolidine	pyrrolidine	ADJ
cet-13158	101	4	concentration	concentration	NOUN
cet-13158	101	5	a	a	DET
cet-13158	101	6	local	local	ADJ
cet-13158	101	7	optimum	optimum	NOUN
cet-13158	101	8	occurs	occur	VERB
cet-13158	101	9	at	at	ADP
cet-13158	101	10	low	low	ADJ
cet-13158	101	11	residence	residence	NOUN
cet-13158	101	12	time	time	NOUN
cet-13158	101	13	and	and	CCONJ
cet-13158	101	14	high	high	ADJ
cet-13158	101	15	temperature	temperature	NOUN
cet-13158	101	16	,	,	PUNCT
cet-13158	101	17	while	while	SCONJ
cet-13158	101	18	at	at	ADP
cet-13158	101	19	high	high	ADJ
cet-13158	101	20	pyrrolidine	pyrrolidine	ADJ
cet-13158	101	21	concentration	concentration	NOUN
cet-13158	101	22	,	,	PUNCT
cet-13158	101	23	the	the	DET
cet-13158	101	24	optimum	optimum	NOUN
cet-13158	101	25	occurs	occur	VERB
cet-13158	101	26	at	at	ADP
cet-13158	101	27	high	high	ADJ
cet-13158	101	28	residence	residence	NOUN
cet-13158	101	29	time	time	NOUN
cet-13158	101	30	and	and	CCONJ
cet-13158	101	31	a	a	DET
cet-13158	101	32	temperature	temperature	NOUN
cet-13158	101	33	of	of	ADP
cet-13158	101	34	60	60	NUM
cet-13158	101	35	°	°	NOUN
cet-13158	101	36	c	c	NOUN
cet-13158	101	37	.	.	PUNCT
cet-13158	102	1	consequently	consequently	ADV
cet-13158	102	2	,	,	PUNCT
cet-13158	102	3	these	these	DET
cet-13158	102	4	two	two	NUM
cet-13158	102	5	experiments	experiment	NOUN
cet-13158	102	6	are	be	AUX
cet-13158	102	7	performed	perform	VERB
cet-13158	102	8	during	during	ADP
cet-13158	102	9	the	the	DET
cet-13158	102	10	first	first	ADJ
cet-13158	102	11	mbdoe	mbdoe	NOUN
cet-13158	102	12	iteration	iteration	NOUN
cet-13158	102	13	.	.	PUNCT
cet-13158	103	1	three	three	NUM
cet-13158	103	2	mbdoe	mbdoe	NOUN
cet-13158	103	3	iterations	iteration	NOUN
cet-13158	103	4	are	be	AUX
cet-13158	103	5	performed	perform	VERB
cet-13158	103	6	,	,	PUNCT
cet-13158	103	7	resulting	result	VERB
cet-13158	103	8	in	in	ADP
cet-13158	103	9	a	a	DET
cet-13158	103	10	total	total	NOUN
cet-13158	103	11	of	of	ADP
cet-13158	103	12	ten	ten	NUM
cet-13158	103	13	experiments	experiment	NOUN
cet-13158	103	14	,	,	PUNCT
cet-13158	103	15	including	include	VERB
cet-13158	103	16	the	the	DET
cet-13158	103	17	initial	initial	ADJ
cet-13158	103	18	four	four	NUM
cet-13158	103	19	ccf	ccf	NOUN
cet-13158	103	20	experiments	experiment	NOUN
cet-13158	103	21	.	.	PUNCT
cet-13158	104	1	thus	thus	ADV
cet-13158	104	2	,	,	PUNCT
cet-13158	104	3	the	the	DET
cet-13158	104	4	mbdoe	mbdoe	NOUN
cet-13158	104	5	approach	approach	NOUN
cet-13158	104	6	is	be	AUX
cet-13158	104	7	conducted	conduct	VERB
cet-13158	104	8	with	with	ADP
cet-13158	104	9	1/3	1/3	NUM
cet-13158	104	10	less	less	ADJ
cet-13158	104	11	experiments	experiment	NOUN
cet-13158	104	12	compared	compare	VERB
cet-13158	104	13	to	to	ADP
cet-13158	104	14	the	the	DET
cet-13158	104	15	full	full	ADJ
cet-13158	104	16	ccf	ccf	NOUN
cet-13158	104	17	design	design	NOUN
cet-13158	104	18	.	.	PUNCT
cet-13158	105	1	figure	figure	NOUN
cet-13158	105	2	5	5	NUM
cet-13158	105	3	shows	show	VERB
cet-13158	105	4	the	the	DET
cet-13158	105	5	estimated	estimate	VERB
cet-13158	105	6	kinetic	kinetic	ADJ
cet-13158	105	7	parameters	parameter	NOUN
cet-13158	105	8	and	and	CCONJ
cet-13158	105	9	the	the	DET
cet-13158	105	10	corresponding	correspond	VERB
cet-13158	105	11	confidence	confidence	NOUN
cet-13158	105	12	interval	interval	NOUN
cet-13158	105	13	for	for	ADP
cet-13158	105	14	each	each	DET
cet-13158	105	15	iteration	iteration	NOUN
cet-13158	105	16	.	.	PUNCT
cet-13158	106	1	figure	figure	NOUN
cet-13158	106	2	5	5	NUM
cet-13158	106	3	:	:	PUNCT
cet-13158	106	4	kinetic	kinetic	ADJ
cet-13158	106	5	constants	constant	NOUN
cet-13158	106	6	and	and	CCONJ
cet-13158	106	7	their	their	PRON
cet-13158	106	8	corresponding	correspond	VERB
cet-13158	106	9	confidence	confidence	NOUN
cet-13158	106	10	interval	interval	NOUN
cet-13158	106	11	as	as	ADP
cet-13158	106	12	function	function	NOUN
cet-13158	106	13	of	of	ADP
cet-13158	106	14	the	the	DET
cet-13158	106	15	iteration	iteration	NOUN
cet-13158	106	16	for	for	ADP
cet-13158	106	17	modelbased	modelbase	VERB
cet-13158	106	18	design	design	NOUN
cet-13158	106	19	of	of	ADP
cet-13158	106	20	experiments	experiment	NOUN
cet-13158	106	21	.	.	PUNCT
cet-13158	107	1	apparently	apparently	ADV
cet-13158	107	2	,	,	PUNCT
cet-13158	107	3	the	the	DET
cet-13158	107	4	confidence	confidence	NOUN
cet-13158	107	5	intervals	interval	NOUN
cet-13158	107	6	are	be	AUX
cet-13158	107	7	effectively	effectively	ADV
cet-13158	107	8	reduced	reduce	VERB
cet-13158	107	9	in	in	ADP
cet-13158	107	10	each	each	DET
cet-13158	107	11	iteration	iteration	NOUN
cet-13158	107	12	of	of	ADP
cet-13158	107	13	the	the	DET
cet-13158	107	14	mbdoe	mbdoe	NOUN
cet-13158	107	15	.	.	PUNCT
cet-13158	108	1	for	for	ADP
cet-13158	108	2	example	example	NOUN
cet-13158	108	3	,	,	PUNCT
cet-13158	108	4	the	the	DET
cet-13158	108	5	confidence	confidence	NOUN
cet-13158	108	6	interval	interval	NOUN
cet-13158	108	7	for	for	ADP
cet-13158	108	8	rate	rate	NOUN
cet-13158	108	9	constant	constant	ADJ
cet-13158	108	10	k0,2	k0,2	PROPN
cet-13158	108	11	is	be	AUX
cet-13158	108	12	improved	improve	VERB
cet-13158	108	13	from	from	ADP
cet-13158	108	14	40	40	NUM
cet-13158	108	15	%	%	NOUN
cet-13158	108	16	for	for	ADP
cet-13158	108	17	the	the	DET
cet-13158	108	18	initial	initial	ADJ
cet-13158	108	19	experiments	experiment	NOUN
cet-13158	108	20	to	to	ADP
cet-13158	108	21	5.5	5.5	NUM
cet-13158	108	22	%	%	NOUN
cet-13158	108	23	with	with	ADP
cet-13158	108	24	the	the	DET
cet-13158	108	25	additional	additional	ADJ
cet-13158	108	26	three	three	NUM
cet-13158	108	27	experiments	experiment	NOUN
cet-13158	108	28	,	,	PUNCT
cet-13158	108	29	while	while	SCONJ
cet-13158	108	30	an	an	DET
cet-13158	108	31	accurate	accurate	ADJ
cet-13158	108	32	estimate	estimate	NOUN
cet-13158	108	33	of	of	ADP
cet-13158	108	34	rate	rate	NOUN
cet-13158	108	35	constant	constant	ADJ
cet-13158	108	36	k0,1	k0,1	NOUN
cet-13158	108	37	is	be	AUX
cet-13158	108	38	determined	determine	VERB
cet-13158	108	39	after	after	ADP
cet-13158	108	40	the	the	DET
cet-13158	108	41	first	first	ADJ
cet-13158	108	42	iteration	iteration	NOUN
cet-13158	108	43	.	.	PUNCT
cet-13158	109	1	also	also	ADV
cet-13158	109	2	,	,	PUNCT
cet-13158	109	3	k0,3	k0,3	PROPN
cet-13158	109	4	and	and	CCONJ
cet-13158	109	5	k0,4	k0,4	PROPN
cet-13158	109	6	,	,	PUNCT
cet-13158	109	7	which	which	PRON
cet-13158	109	8	are	be	AUX
cet-13158	109	9	practically	practically	ADV
cet-13158	109	10	unidentifiable	unidentifiable	ADJ
cet-13158	109	11	with	with	ADP
cet-13158	109	12	the	the	DET
cet-13158	109	13	ccf	ccf	PROPN
cet-13158	109	14	design	design	NOUN
cet-13158	109	15	,	,	PUNCT
cet-13158	109	16	are	be	AUX
cet-13158	109	17	determined	determine	VERB
cet-13158	109	18	with	with	ADP
cet-13158	109	19	confidence	confidence	NOUN
cet-13158	109	20	intervals	interval	NOUN
cet-13158	109	21	below	below	ADP
cet-13158	109	22	100	100	NUM
cet-13158	109	23	%	%	NOUN
cet-13158	109	24	.	.	PUNCT
cet-13158	110	1	the	the	DET
cet-13158	110	2	estimated	estimate	VERB
cet-13158	110	3	rate	rate	NOUN
cet-13158	110	4	constants	constant	NOUN
cet-13158	110	5	after	after	SCONJ
cet-13158	110	6	the	the	DET
cet-13158	110	7	last	last	ADJ
cet-13158	110	8	mbdoe	mbdoe	NOUN
cet-13158	110	9	iteration	iteration	NOUN
cet-13158	110	10	are	be	AUX
cet-13158	110	11	summarized	summarize	VERB
cet-13158	110	12	in	in	ADP
cet-13158	110	13	table	table	NOUN
cet-13158	110	14	2	2	NUM
cet-13158	110	15	.	.	PUNCT
cet-13158	110	16	table	table	NOUN
cet-13158	110	17	2	2	NUM
cet-13158	110	18	:	:	PUNCT
cet-13158	110	19	kinetic	kinetic	ADJ
cet-13158	110	20	parameter	parameter	NOUN
cet-13158	110	21	estimation	estimation	NOUN
cet-13158	110	22	for	for	ADP
cet-13158	110	23	the	the	DET
cet-13158	110	24	model	model	NOUN
cet-13158	110	25	-	-	PUNCT
cet-13158	110	26	based	base	VERB
cet-13158	110	27	design	design	NOUN
cet-13158	110	28	of	of	ADP
cet-13158	110	29	experiments	experiment	NOUN
cet-13158	110	30	rate	rate	NOUN
cet-13158	110	31	step	step	NOUN
cet-13158	110	32	k0	k0	PROPN
cet-13158	111	1	[	[	X
cet-13158	111	2	l	l	NOUN
cet-13158	111	3	/	/	SYM
cet-13158	111	4	mol	mol	PROPN
cet-13158	111	5	/	/	SYM
cet-13158	111	6	s	s	PART
cet-13158	111	7	]	]	PUNCT
cet-13158	111	8	ea	ea	NOUN
cet-13158	112	1	[	[	X
cet-13158	112	2	kj	kj	PROPN
cet-13158	112	3	/	/	SYM
cet-13158	112	4	mol	mol	NOUN
cet-13158	112	5	]	]	SYM
cet-13158	112	6	1	1	NUM
cet-13158	112	7	0.204	0.204	NUM
cet-13158	112	8	±	±	NUM
cet-13158	112	9	1.7	1.7	NUM
cet-13158	112	10	%	%	NOUN
cet-13158	112	11	50.5	50.5	NUM
cet-13158	112	12	±	±	NUM
cet-13158	112	13	1	1	NUM
cet-13158	112	14	%	%	NOUN
cet-13158	112	15	2	2	NUM
cet-13158	112	16	0.0245	0.0245	NUM
cet-13158	112	17	±	±	NUM
cet-13158	112	18	5.5	5.5	NUM
cet-13158	112	19	%	%	NOUN
cet-13158	112	20	53.2	53.2	NUM
cet-13158	112	21	±	±	NUM
cet-13158	112	22	2.8	2.8	NUM
cet-13158	112	23	%	%	NOUN
cet-13158	112	24	3	3	NUM
cet-13158	112	25	1.86·10	1.86·10	NUM
cet-13158	112	26	-	-	SYM
cet-13158	112	27	5	5	NUM
cet-13158	112	28	±	±	NUM
cet-13158	112	29	98	98	NUM
cet-13158	112	30	%	%	NOUN
cet-13158	112	31	67.8	67.8	NUM
cet-13158	112	32	±	±	NUM
cet-13158	112	33	34	34	NUM
cet-13158	112	34	%	%	NOUN
cet-13158	112	35	4	4	NUM
cet-13158	112	36	1.42·10	1.42·10	NUM
cet-13158	112	37	-	-	SYM
cet-13158	112	38	3	3	NUM
cet-13158	112	39	±	±	NUM
cet-13158	112	40	38	38	NUM
cet-13158	112	41	%	%	NOUN
cet-13158	112	42	45.0	45.0	NUM
cet-13158	112	43	±	±	NUM
cet-13158	112	44	21	21	NUM
cet-13158	112	45	%	%	NOUN
cet-13158	112	46	compared	compare	VERB
cet-13158	112	47	to	to	ADP
cet-13158	112	48	the	the	DET
cet-13158	112	49	rate	rate	NOUN
cet-13158	112	50	constants	constant	NOUN
cet-13158	112	51	calculated	calculate	VERB
cet-13158	112	52	with	with	ADP
cet-13158	112	53	the	the	DET
cet-13158	112	54	ccf	ccf	PROPN
cet-13158	112	55	design	design	NOUN
cet-13158	112	56	(	(	PUNCT
cet-13158	112	57	table	table	NOUN
cet-13158	112	58	1	1	NUM
cet-13158	112	59	)	)	PUNCT
cet-13158	112	60	,	,	PUNCT
cet-13158	112	61	especially	especially	ADV
cet-13158	112	62	the	the	DET
cet-13158	112	63	reaction	reaction	NOUN
cet-13158	112	64	constants	constant	NOUN
cet-13158	112	65	for	for	ADP
cet-13158	112	66	the	the	DET
cet-13158	112	67	consecutive	consecutive	ADJ
cet-13158	112	68	reactions	reaction	NOUN
cet-13158	112	69	are	be	AUX
cet-13158	112	70	determined	determine	VERB
cet-13158	112	71	with	with	ADP
cet-13158	112	72	significantly	significantly	ADV
cet-13158	112	73	higher	high	ADJ
cet-13158	112	74	accuracy	accuracy	NOUN
cet-13158	112	75	,	,	PUNCT
cet-13158	112	76	despite	despite	SCONJ
cet-13158	112	77	the	the	DET
cet-13158	112	78	fact	fact	NOUN
cet-13158	112	79	that	that	SCONJ
cet-13158	112	80	considerably	considerably	ADV
cet-13158	112	81	fewer	few	ADJ
cet-13158	112	82	experiments	experiment	NOUN
cet-13158	112	83	are	be	AUX
cet-13158	112	84	carried	carry	VERB
cet-13158	112	85	out	out	ADP
cet-13158	112	86	.	.	PUNCT
cet-13158	113	1	nevertheless	nevertheless	ADV
cet-13158	113	2	,	,	PUNCT
cet-13158	113	3	rate	rate	NOUN
cet-13158	113	4	step	step	NOUN
cet-13158	113	5	3	3	NUM
cet-13158	113	6	is	be	AUX
cet-13158	113	7	significantly	significantly	ADV
cet-13158	113	8	slower	slow	ADJ
cet-13158	113	9	than	than	ADP
cet-13158	113	10	rate	rate	NOUN
cet-13158	113	11	step	step	NOUN
cet-13158	113	12	4	4	NUM
cet-13158	113	13	with	with	ADP
cet-13158	113	14	a	a	DET
cet-13158	113	15	high	high	ADJ
cet-13158	113	16	activation	activation	NOUN
cet-13158	113	17	energy	energy	NOUN
cet-13158	113	18	and	and	CCONJ
cet-13158	113	19	therefore	therefore	ADV
cet-13158	113	20	almost	almost	ADV
cet-13158	113	21	negligible	negligible	ADJ
cet-13158	113	22	in	in	ADP
cet-13158	113	23	the	the	DET
cet-13158	113	24	studied	study	VERB
cet-13158	113	25	temperature	temperature	NOUN
cet-13158	113	26	range	range	NOUN
cet-13158	113	27	.	.	PUNCT
cet-13158	114	1	this	this	DET
cet-13158	114	2	results	result	VERB
cet-13158	114	3	in	in	ADP
cet-13158	114	4	the	the	DET
cet-13158	114	5	remaining	remain	VERB
cet-13158	114	6	high	high	ADJ
cet-13158	114	7	uncertainty	uncertainty	NOUN
cet-13158	114	8	for	for	ADP
cet-13158	114	9	the	the	DET
cet-13158	114	10	kinetic	kinetic	ADJ
cet-13158	114	11	parameters	parameter	NOUN
cet-13158	114	12	for	for	ADP
cet-13158	114	13	rate	rate	NOUN
cet-13158	114	14	step	step	NOUN
cet-13158	114	15	3	3	NUM
cet-13158	114	16	.	.	PUNCT
cet-13158	115	1	the	the	DET
cet-13158	115	2	effect	effect	NOUN
cet-13158	115	3	of	of	ADP
cet-13158	115	4	the	the	DET
cet-13158	115	5	improved	improve	VERB
cet-13158	115	6	experimental	experimental	ADJ
cet-13158	115	7	design	design	NOUN
cet-13158	115	8	is	be	AUX
cet-13158	115	9	479	479	NUM
cet-13158	115	10	illustrated	illustrate	VERB
cet-13158	115	11	best	good	ADJ
cet-13158	115	12	by	by	ADP
cet-13158	115	13	means	mean	NOUN
cet-13158	115	14	of	of	ADP
cet-13158	115	15	the	the	DET
cet-13158	115	16	(	(	PUNCT
cet-13158	115	17	pointwise	pointwise	PROPN
cet-13158	115	18	95	95	NUM
cet-13158	115	19	%	%	NOUN
cet-13158	115	20	)	)	PUNCT
cet-13158	115	21	confidence	confidence	NOUN
cet-13158	115	22	bands	band	NOUN
cet-13158	115	23	of	of	ADP
cet-13158	115	24	reaction	reaction	NOUN
cet-13158	115	25	step	step	NOUN
cet-13158	115	26	2	2	NUM
cet-13158	115	27	and	and	CCONJ
cet-13158	115	28	4	4	NUM
cet-13158	115	29	in	in	ADP
cet-13158	115	30	figure	figure	NOUN
cet-13158	115	31	6	6	NUM
cet-13158	115	32	.	.	PUNCT
cet-13158	116	1	the	the	DET
cet-13158	116	2	reaction	reaction	NOUN
cet-13158	116	3	rates	rate	NOUN
cet-13158	116	4	k2	k2	NOUN
cet-13158	116	5	and	and	CCONJ
cet-13158	116	6	k4	k4	NOUN
cet-13158	116	7	as	as	ADV
cet-13158	116	8	well	well	ADV
cet-13158	116	9	as	as	ADP
cet-13158	116	10	the	the	DET
cet-13158	116	11	respective	respective	ADJ
cet-13158	116	12	confidence	confidence	NOUN
cet-13158	116	13	bands	band	NOUN
cet-13158	116	14	are	be	AUX
cet-13158	116	15	plotted	plot	VERB
cet-13158	116	16	as	as	ADP
cet-13158	116	17	function	function	NOUN
cet-13158	116	18	of	of	ADP
cet-13158	116	19	the	the	DET
cet-13158	116	20	temperature	temperature	NOUN
cet-13158	116	21	for	for	ADP
cet-13158	116	22	the	the	DET
cet-13158	116	23	kinetic	kinetic	ADJ
cet-13158	116	24	models	model	NOUN
cet-13158	116	25	,	,	PUNCT
cet-13158	116	26	as	as	SCONJ
cet-13158	116	27	derived	derive	VERB
cet-13158	116	28	from	from	ADP
cet-13158	116	29	the	the	DET
cet-13158	116	30	ccf	ccf	NOUN
cet-13158	116	31	,	,	PUNCT
cet-13158	116	32	the	the	DET
cet-13158	116	33	mbdoe	mbdoe	NOUN
cet-13158	116	34	and	and	CCONJ
cet-13158	116	35	a	a	DET
cet-13158	116	36	simple	simple	ADJ
cet-13158	116	37	intuitive	intuitive	ADJ
cet-13158	116	38	study	study	NOUN
cet-13158	116	39	,	,	PUNCT
cet-13158	116	40	where	where	SCONJ
cet-13158	116	41	one	one	NUM
cet-13158	116	42	-	-	PUNCT
cet-13158	116	43	factor	factor	NOUN
cet-13158	116	44	-	-	PUNCT
cet-13158	116	45	ata	ata	NOUN
cet-13158	116	46	-	-	PUNCT
cet-13158	116	47	time	time	NOUN
cet-13158	116	48	(	(	PUNCT
cet-13158	116	49	ofat	ofat	PROPN
cet-13158	116	50	)	)	PUNCT
cet-13158	116	51	is	be	AUX
cet-13158	116	52	investigated	investigate	VERB
cet-13158	116	53	in	in	ADP
cet-13158	116	54	20	20	NUM
cet-13158	116	55	experiments	experiment	NOUN
cet-13158	116	56	.	.	PUNCT
cet-13158	117	1	in	in	ADP
cet-13158	117	2	the	the	DET
cet-13158	117	3	ofat	ofat	NOUN
cet-13158	117	4	approach	approach	NOUN
cet-13158	117	5	,	,	PUNCT
cet-13158	117	6	the	the	DET
cet-13158	117	7	residence	residence	NOUN
cet-13158	117	8	time	time	NOUN
cet-13158	117	9	is	be	AUX
cet-13158	117	10	varied	varied	ADJ
cet-13158	117	11	during	during	ADP
cet-13158	117	12	the	the	DET
cet-13158	117	13	experiments	experiment	NOUN
cet-13158	117	14	while	while	SCONJ
cet-13158	117	15	the	the	DET
cet-13158	117	16	concentration	concentration	NOUN
cet-13158	117	17	and	and	CCONJ
cet-13158	117	18	temperature	temperature	NOUN
cet-13158	117	19	are	be	AUX
cet-13158	117	20	kept	keep	VERB
cet-13158	117	21	constant	constant	ADJ
cet-13158	117	22	.	.	PUNCT
cet-13158	118	1	figure	figure	VERB
cet-13158	118	2	6	6	NUM
cet-13158	118	3	:	:	PUNCT
cet-13158	118	4	reaction	reaction	NOUN
cet-13158	118	5	rate	rate	NOUN
cet-13158	118	6	(	(	PUNCT
cet-13158	118	7	a	a	NOUN
cet-13158	118	8	)	)	PUNCT
cet-13158	118	9	k2	k2	NOUN
cet-13158	118	10	and	and	CCONJ
cet-13158	118	11	(	(	PUNCT
cet-13158	118	12	b	b	NOUN
cet-13158	118	13	)	)	PUNCT
cet-13158	118	14	k4	k4	NOUN
cet-13158	118	15	as	as	ADP
cet-13158	118	16	function	function	NOUN
cet-13158	118	17	of	of	ADP
cet-13158	118	18	the	the	DET
cet-13158	118	19	temperature	temperature	NOUN
cet-13158	118	20	for	for	ADP
cet-13158	118	21	a	a	DET
cet-13158	118	22	simple	simple	ADJ
cet-13158	118	23	design	design	NOUN
cet-13158	118	24	plan	plan	NOUN
cet-13158	118	25	,	,	PUNCT
cet-13158	118	26	the	the	DET
cet-13158	118	27	factorial	factorial	ADJ
cet-13158	118	28	design	design	NOUN
cet-13158	118	29	of	of	ADP
cet-13158	118	30	experiments	experiment	NOUN
cet-13158	118	31	and	and	CCONJ
cet-13158	118	32	the	the	DET
cet-13158	118	33	model	model	NOUN
cet-13158	118	34	-	-	PUNCT
cet-13158	118	35	based	base	VERB
cet-13158	118	36	design	design	NOUN
cet-13158	118	37	of	of	ADP
cet-13158	118	38	experiments	experiment	NOUN
cet-13158	118	39	.	.	PUNCT
cet-13158	119	1	while	while	SCONJ
cet-13158	119	2	there	there	PRON
cet-13158	119	3	are	be	VERB
cet-13158	119	4	only	only	ADV
cet-13158	119	5	little	little	ADJ
cet-13158	119	6	differences	difference	NOUN
cet-13158	119	7	between	between	ADP
cet-13158	119	8	the	the	DET
cet-13158	119	9	model	model	NOUN
cet-13158	119	10	results	result	NOUN
cet-13158	119	11	,	,	PUNCT
cet-13158	119	12	with	with	ADP
cet-13158	119	13	a	a	DET
cet-13158	119	14	noticeably	noticeably	ADV
cet-13158	119	15	smaller	small	ADJ
cet-13158	119	16	confidence	confidence	NOUN
cet-13158	119	17	band	band	NOUN
cet-13158	119	18	for	for	ADP
cet-13158	119	19	the	the	DET
cet-13158	119	20	mbdoe	mbdoe	NOUN
cet-13158	119	21	,	,	PUNCT
cet-13158	119	22	for	for	ADP
cet-13158	119	23	reaction	reaction	NOUN
cet-13158	119	24	rate	rate	NOUN
cet-13158	119	25	k2	k2	PROPN
cet-13158	119	26	,	,	PUNCT
cet-13158	119	27	the	the	DET
cet-13158	119	28	advantage	advantage	NOUN
cet-13158	119	29	of	of	ADP
cet-13158	119	30	the	the	DET
cet-13158	119	31	mbdoe	mbdoe	NOUN
cet-13158	119	32	becomes	become	VERB
cet-13158	119	33	significant	significant	ADJ
cet-13158	119	34	for	for	ADP
cet-13158	119	35	modelling	model	VERB
cet-13158	119	36	k4	k4	NOUN
cet-13158	119	37	.	.	PUNCT
cet-13158	120	1	only	only	ADV
cet-13158	120	2	the	the	DET
cet-13158	120	3	mbdoe	mbdoe	NOUN
cet-13158	120	4	provides	provide	VERB
cet-13158	120	5	a	a	DET
cet-13158	120	6	confined	confine	VERB
cet-13158	120	7	confidence	confidence	NOUN
cet-13158	120	8	band	band	NOUN
cet-13158	120	9	,	,	PUNCT
cet-13158	120	10	while	while	SCONJ
cet-13158	120	11	the	the	DET
cet-13158	120	12	confidence	confidence	NOUN
cet-13158	120	13	bands	band	NOUN
cet-13158	120	14	for	for	ADP
cet-13158	120	15	the	the	DET
cet-13158	120	16	other	other	ADJ
cet-13158	120	17	experimental	experimental	ADJ
cet-13158	120	18	plans	plan	NOUN
cet-13158	120	19	extend	extend	VERB
cet-13158	120	20	largely	largely	ADV
cet-13158	120	21	,	,	PUNCT
cet-13158	120	22	demonstrating	demonstrate	VERB
cet-13158	120	23	the	the	DET
cet-13158	120	24	improved	improved	ADJ
cet-13158	120	25	parameter	parameter	NOUN
cet-13158	120	26	identifiability	identifiability	NOUN
cet-13158	120	27	using	use	VERB
cet-13158	120	28	mbdoe	mbdoe	NOUN
cet-13158	120	29	.	.	PUNCT
cet-13158	121	1	4	4	X
cet-13158	121	2	.	.	X
cet-13158	121	3	conclusions	conclusion	NOUN
cet-13158	121	4	this	this	DET
cet-13158	121	5	work	work	NOUN
cet-13158	121	6	illustrates	illustrate	VERB
cet-13158	121	7	that	that	SCONJ
cet-13158	121	8	the	the	DET
cet-13158	121	9	integration	integration	NOUN
cet-13158	121	10	of	of	ADP
cet-13158	121	11	mbdoe	mbdoe	NOUN
cet-13158	121	12	with	with	ADP
cet-13158	121	13	the	the	DET
cet-13158	121	14	well	well	ADV
cet-13158	121	15	-	-	PUNCT
cet-13158	121	16	defined	define	VERB
cet-13158	121	17	art	art	NOUN
cet-13158	121	18	reactor	reactor	NOUN
cet-13158	121	19	allows	allow	VERB
cet-13158	121	20	to	to	PART
cet-13158	121	21	identify	identify	VERB
cet-13158	121	22	the	the	DET
cet-13158	121	23	kinetics	kinetic	NOUN
cet-13158	121	24	of	of	ADP
cet-13158	121	25	a	a	DET
cet-13158	121	26	multi	multi	ADJ
cet-13158	121	27	-	-	ADJ
cet-13158	121	28	step	step	ADJ
cet-13158	121	29	reaction	reaction	NOUN
cet-13158	121	30	with	with	ADP
cet-13158	121	31	less	less	ADJ
cet-13158	121	32	experimental	experimental	ADJ
cet-13158	121	33	effort	effort	NOUN
cet-13158	121	34	comparing	compare	VERB
cet-13158	121	35	to	to	ADP
cet-13158	121	36	a	a	DET
cet-13158	121	37	static	static	ADJ
cet-13158	121	38	doe	doe	NOUN
cet-13158	121	39	.	.	PUNCT
cet-13158	122	1	especially	especially	ADV
cet-13158	122	2	,	,	PUNCT
cet-13158	122	3	the	the	DET
cet-13158	122	4	rate	rate	NOUN
cet-13158	122	5	constants	constant	NOUN
cet-13158	122	6	for	for	ADP
cet-13158	122	7	the	the	DET
cet-13158	122	8	consecutive	consecutive	ADJ
cet-13158	122	9	reactions	reaction	NOUN
cet-13158	122	10	are	be	AUX
cet-13158	122	11	determined	determine	VERB
cet-13158	122	12	with	with	ADP
cet-13158	122	13	significantly	significantly	ADV
cet-13158	122	14	improved	improve	VERB
cet-13158	122	15	accuracy	accuracy	NOUN
cet-13158	122	16	despite	despite	SCONJ
cet-13158	122	17	a	a	DET
cet-13158	122	18	smaller	small	ADJ
cet-13158	122	19	number	number	NOUN
cet-13158	122	20	of	of	ADP
cet-13158	122	21	experiments	experiment	NOUN
cet-13158	122	22	.	.	PUNCT
cet-13158	123	1	after	after	ADP
cet-13158	123	2	showing	show	VERB
cet-13158	123	3	the	the	DET
cet-13158	123	4	high	high	ADJ
cet-13158	123	5	potential	potential	NOUN
cet-13158	123	6	of	of	ADP
cet-13158	123	7	applying	apply	VERB
cet-13158	123	8	mbdoe	mbdoe	NOUN
cet-13158	123	9	in	in	ADP
cet-13158	123	10	the	the	DET
cet-13158	123	11	art	art	NOUN
cet-13158	123	12	reactor	reactor	NOUN
cet-13158	123	13	for	for	ADP
cet-13158	123	14	the	the	DET
cet-13158	123	15	efficient	efficient	ADJ
cet-13158	123	16	identification	identification	NOUN
cet-13158	123	17	of	of	ADP
cet-13158	123	18	kinetic	kinetic	ADJ
cet-13158	123	19	models	model	NOUN
cet-13158	123	20	via	via	ADP
cet-13158	123	21	offline	offline	ADJ
cet-13158	123	22	experiments	experiment	NOUN
cet-13158	123	23	,	,	PUNCT
cet-13158	123	24	future	future	ADJ
cet-13158	123	25	work	work	NOUN
cet-13158	123	26	aims	aim	VERB
cet-13158	123	27	at	at	ADP
cet-13158	123	28	the	the	DET
cet-13158	123	29	realization	realization	NOUN
cet-13158	123	30	of	of	ADP
cet-13158	123	31	a	a	DET
cet-13158	123	32	closed	closed	ADJ
cet-13158	123	33	-	-	PUNCT
cet-13158	123	34	loop	loop	NOUN
cet-13158	123	35	system	system	NOUN
cet-13158	123	36	,	,	PUNCT
cet-13158	123	37	in	in	ADP
cet-13158	123	38	which	which	PRON
cet-13158	123	39	the	the	DET
cet-13158	123	40	reactor	reactor	NOUN
cet-13158	123	41	is	be	AUX
cet-13158	123	42	linked	link	VERB
cet-13158	123	43	with	with	ADP
cet-13158	123	44	online	online	ADJ
cet-13158	123	45	analytics	analytic	NOUN
cet-13158	123	46	and	and	CCONJ
cet-13158	123	47	an	an	DET
cet-13158	123	48	automated	automate	VERB
cet-13158	123	49	process	process	NOUN
cet-13158	123	50	control	control	NOUN
cet-13158	123	51	system	system	NOUN
cet-13158	123	52	.	.	PUNCT
cet-13158	124	1	with	with	ADP
cet-13158	124	2	this	this	DET
cet-13158	124	3	setting	setting	NOUN
cet-13158	124	4	,	,	PUNCT
cet-13158	124	5	mbdoe	mbdoe	NOUN
cet-13158	124	6	will	will	AUX
cet-13158	124	7	enable	enable	VERB
cet-13158	124	8	a	a	DET
cet-13158	124	9	fully	fully	ADV
cet-13158	124	10	automated	automate	VERB
cet-13158	124	11	platform	platform	NOUN
cet-13158	124	12	for	for	ADP
cet-13158	124	13	model	model	NOUN
cet-13158	124	14	identification	identification	NOUN
cet-13158	124	15	.	.	PUNCT
cet-13158	125	1	references	reference	NOUN
cet-13158	125	2	fath	fath	PROPN
cet-13158	125	3	v.	v.	PROPN
cet-13158	125	4	,	,	PUNCT
cet-13158	125	5	lau	lau	PROPN
cet-13158	125	6	p.	p.	PROPN
cet-13158	125	7	,	,	PUNCT
cet-13158	125	8	greve	greve	PROPN
cet-13158	125	9	c.	c.	PROPN
cet-13158	125	10	,	,	PUNCT
cet-13158	125	11	kockmann	kockmann	PROPN
cet-13158	125	12	n.	n.	PROPN
cet-13158	125	13	,	,	PUNCT
cet-13158	125	14	röder	röder	NOUN
cet-13158	125	15	t.	t.	PROPN
cet-13158	125	16	,	,	PUNCT
cet-13158	125	17	2020	2020	NUM
cet-13158	125	18	,	,	PUNCT
cet-13158	125	19	efficient	efficient	ADJ
cet-13158	125	20	kinetic	kinetic	ADJ
cet-13158	125	21	data	datum	NOUN
cet-13158	125	22	acquisition	acquisition	NOUN
cet-13158	125	23	and	and	CCONJ
cet-13158	125	24	model	model	NOUN
cet-13158	125	25	prediction	prediction	NOUN
cet-13158	125	26	:	:	PUNCT
cet-13158	125	27	continuous	continuous	ADJ
cet-13158	125	28	flow	flow	NOUN
cet-13158	125	29	microreactors	microreactor	NOUN
cet-13158	125	30	,	,	PUNCT
cet-13158	125	31	inline	inline	VERB
cet-13158	125	32	fourier	fourier	NOUN
cet-13158	125	33	transform	transform	VERB
cet-13158	125	34	infrared	infrared	ADJ
cet-13158	125	35	spectroscopy	spectroscopy	NOUN
cet-13158	125	36	,	,	PUNCT
cet-13158	125	37	and	and	CCONJ
cet-13158	125	38	self	self	NOUN
cet-13158	125	39	-	-	PUNCT
cet-13158	125	40	modeling	model	VERB
cet-13158	125	41	curve	curve	NOUN
cet-13158	125	42	resolution	resolution	NOUN
cet-13158	125	43	,	,	PUNCT
cet-13158	125	44	organic	organic	ADJ
cet-13158	125	45	process	process	NOUN
cet-13158	125	46	research	research	NOUN
cet-13158	125	47	&	&	CCONJ
cet-13158	125	48	development	development	PROPN
cet-13158	125	49	,	,	PUNCT
cet-13158	125	50	24	24	NUM
cet-13158	125	51	,	,	PUNCT
cet-13158	125	52	1955–1968	1955–1968	NUM
cet-13158	125	53	.	.	PUNCT
cet-13158	126	1	franceschini	franceschini	PROPN
cet-13158	126	2	g.	g.	PROPN
cet-13158	126	3	,	,	PUNCT
cet-13158	126	4	macchietto	macchietto	PROPN
cet-13158	126	5	s.	s.	PROPN
cet-13158	126	6	,	,	PUNCT
cet-13158	126	7	2008	2008	NUM
cet-13158	126	8	,	,	PUNCT
cet-13158	126	9	model	model	NOUN
cet-13158	126	10	-	-	PUNCT
cet-13158	126	11	based	base	VERB
cet-13158	126	12	design	design	NOUN
cet-13158	126	13	of	of	ADP
cet-13158	126	14	experiments	experiment	NOUN
cet-13158	126	15	for	for	ADP
cet-13158	126	16	parameter	parameter	NOUN
cet-13158	126	17	precision	precision	NOUN
cet-13158	126	18	:	:	PUNCT
cet-13158	126	19	state	state	NOUN
cet-13158	126	20	of	of	ADP
cet-13158	126	21	the	the	DET
cet-13158	126	22	art	art	NOUN
cet-13158	126	23	,	,	PUNCT
cet-13158	126	24	chemical	chemical	NOUN
cet-13158	126	25	engineering	engineering	NOUN
cet-13158	126	26	science	science	NOUN
cet-13158	126	27	,	,	PUNCT
cet-13158	126	28	63	63	NUM
cet-13158	126	29	,	,	PUNCT
cet-13158	126	30	4846–4872	4846–4872	NUM
cet-13158	126	31	.	.	PUNCT
cet-13158	127	1	hone	hone	PROPN
cet-13158	127	2	c.a	c.a	PROPN
cet-13158	127	3	.	.	PROPN
cet-13158	127	4	,	,	PUNCT
cet-13158	127	5	holmes	holmes	PROPN
cet-13158	127	6	n.	n.	PROPN
cet-13158	127	7	,	,	PUNCT
cet-13158	127	8	akien	akien	PROPN
cet-13158	127	9	g.r	g.r	PROPN
cet-13158	127	10	.	.	PROPN
cet-13158	127	11	,	,	PUNCT
cet-13158	127	12	bourne	bourne	PROPN
cet-13158	127	13	r.a	r.a	PROPN
cet-13158	127	14	.	.	PROPN
cet-13158	127	15	,	,	PUNCT
cet-13158	127	16	muller	muller	PROPN
cet-13158	127	17	f.l	f.l	PROPN
cet-13158	127	18	.	.	PROPN
cet-13158	127	19	,	,	PUNCT
cet-13158	127	20	2017	2017	NUM
cet-13158	127	21	,	,	PUNCT
cet-13158	127	22	rapid	rapid	ADJ
cet-13158	127	23	multistep	multistep	ADJ
cet-13158	127	24	kinetic	kinetic	NOUN
cet-13158	127	25	model	model	NOUN
cet-13158	127	26	generation	generation	NOUN
cet-13158	127	27	from	from	ADP
cet-13158	127	28	transient	transient	ADJ
cet-13158	127	29	flow	flow	NOUN
cet-13158	127	30	data	datum	NOUN
cet-13158	127	31	,	,	PUNCT
cet-13158	127	32	reaction	reaction	NOUN
cet-13158	127	33	chemistry	chemistry	NOUN
cet-13158	127	34	&	&	CCONJ
cet-13158	127	35	engineering	engineering	PROPN
cet-13158	127	36	,	,	PUNCT
cet-13158	127	37	2	2	NUM
cet-13158	127	38	,	,	PUNCT
cet-13158	127	39	103–108	103–108	NUM
cet-13158	127	40	.	.	PUNCT
cet-13158	128	1	martins	martin	VERB
cet-13158	128	2	j.r.r.a	j.r.r.a	PROPN
cet-13158	128	3	.	.	PROPN
cet-13158	128	4	,	,	PUNCT
cet-13158	128	5	sturdza	sturdza	PROPN
cet-13158	128	6	p.	p.	PROPN
cet-13158	128	7	,	,	PUNCT
cet-13158	128	8	alonso	alonso	PROPN
cet-13158	128	9	j.j	j.j	PROPN
cet-13158	128	10	.	.	PROPN
cet-13158	128	11	,	,	PUNCT
cet-13158	128	12	2003	2003	NUM
cet-13158	128	13	,	,	PUNCT
cet-13158	128	14	the	the	DET
cet-13158	128	15	complex	complex	ADJ
cet-13158	128	16	-	-	PUNCT
cet-13158	128	17	step	step	NOUN
cet-13158	128	18	derivative	derivative	ADJ
cet-13158	128	19	approximation	approximation	NOUN
cet-13158	128	20	,	,	PUNCT
cet-13158	128	21	acm	acm	NOUN
cet-13158	128	22	transactions	transaction	NOUN
cet-13158	128	23	on	on	ADP
cet-13158	128	24	mathematical	mathematical	ADJ
cet-13158	128	25	software	software	NOUN
cet-13158	128	26	,	,	PUNCT
cet-13158	128	27	29	29	NUM
cet-13158	128	28	,	,	PUNCT
cet-13158	128	29	245–262	245–262	NUM
cet-13158	128	30	.	.	PUNCT
cet-13158	129	1	rave	rave	PROPN
cet-13158	129	2	a.	a.	PROPN
cet-13158	129	3	,	,	PUNCT
cet-13158	129	4	kuwertz	kuwertz	PROPN
cet-13158	129	5	r.	r.	PROPN
cet-13158	129	6	,	,	PUNCT
cet-13158	129	7	fieg	fieg	PROPN
cet-13158	129	8	g.	g.	PROPN
cet-13158	129	9	,	,	PUNCT
cet-13158	129	10	heck	heck	INTJ
cet-13158	129	11	j.	j.	PROPN
cet-13158	129	12	,	,	PUNCT
cet-13158	129	13	2019	2019	NUM
cet-13158	129	14	,	,	PUNCT
cet-13158	129	15	characterization	characterization	NOUN
cet-13158	129	16	of	of	ADP
cet-13158	129	17	a	a	DET
cet-13158	129	18	modular	modular	ADJ
cet-13158	129	19	,	,	PUNCT
cet-13158	129	20	scalable	scalable	ADJ
cet-13158	129	21	millistructured	millistructured	ADJ
cet-13158	129	22	plate	plate	NOUN
cet-13158	129	23	reactor	reactor	NOUN
cet-13158	129	24	,	,	PUNCT
cet-13158	129	25	chemie	chemie	PROPN
cet-13158	129	26	ingenieur	ingenieur	PROPN
cet-13158	129	27	technik	technik	PROPN
cet-13158	129	28	,	,	PUNCT
cet-13158	129	29	91	91	NUM
cet-13158	129	30	,	,	PUNCT
cet-13158	129	31	602–606	602–606	NUM
cet-13158	129	32	.	.	PUNCT
cet-13158	130	1	rave	rave	PROPN
cet-13158	130	2	a.	a.	PROPN
cet-13158	130	3	,	,	PUNCT
cet-13158	130	4	kuwertz	kuwertz	PROPN
cet-13158	130	5	r.	r.	PROPN
cet-13158	130	6	,	,	PUNCT
cet-13158	130	7	fieg	fieg	PROPN
cet-13158	130	8	g.	g.	PROPN
cet-13158	130	9	,	,	PUNCT
cet-13158	130	10	heck	heck	INTJ
cet-13158	130	11	j.	j.	PROPN
cet-13158	130	12	,	,	PUNCT
cet-13158	130	13	2020	2020	NUM
cet-13158	130	14	,	,	PUNCT
cet-13158	130	15	modeling	modeling	NOUN
cet-13158	130	16	and	and	CCONJ
cet-13158	130	17	experimental	experimental	ADJ
cet-13158	130	18	investigation	investigation	NOUN
cet-13158	130	19	of	of	ADP
cet-13158	130	20	the	the	DET
cet-13158	130	21	spatial	spatial	ADJ
cet-13158	130	22	heat	heat	NOUN
cet-13158	130	23	transfer	transfer	NOUN
cet-13158	130	24	in	in	ADP
cet-13158	130	25	a	a	DET
cet-13158	130	26	plate	plate	NOUN
cet-13158	130	27	reactor	reactor	NOUN
cet-13158	130	28	with	with	ADP
cet-13158	130	29	meandering	meander	VERB
cet-13158	130	30	millichannels	millichannel	NOUN
cet-13158	130	31	,	,	PUNCT
cet-13158	130	32	chemical	chemical	NOUN
cet-13158	130	33	engineering	engineering	NOUN
cet-13158	130	34	and	and	CCONJ
cet-13158	130	35	processing	processing	NOUN
cet-13158	130	36	process	process	NOUN
cet-13158	130	37	intensification	intensification	NOUN
cet-13158	130	38	,	,	PUNCT
cet-13158	130	39	150	150	NUM
cet-13158	130	40	,	,	PUNCT
cet-13158	130	41	107860	107860	NUM
cet-13158	130	42	.	.	PUNCT
cet-13158	131	1	rave	rave	PROPN
cet-13158	131	2	a.	a.	PROPN
cet-13158	131	3	,	,	PUNCT
cet-13158	131	4	schaare	schaare	VERB
cet-13158	131	5	l.	l.	PROPN
cet-13158	131	6	,	,	PUNCT
cet-13158	131	7	fieg	fieg	PROPN
cet-13158	131	8	g.	g.	PROPN
cet-13158	131	9	,	,	PUNCT
cet-13158	131	10	2022	2022	NUM
cet-13158	131	11	,	,	PUNCT
cet-13158	131	12	investigation	investigation	NOUN
cet-13158	131	13	of	of	ADP
cet-13158	131	14	micromixing	micromixe	VERB
cet-13158	131	15	in	in	ADP
cet-13158	131	16	the	the	DET
cet-13158	131	17	art	art	NOUN
cet-13158	131	18	plate	plate	NOUN
cet-13158	131	19	reactor	reactor	NOUN
cet-13158	131	20	pr37	pr37	PROPN
cet-13158	131	21	using	use	VERB
cet-13158	131	22	the	the	DET
cet-13158	131	23	acetal	acetal	ADJ
cet-13158	131	24	cleavage	cleavage	NOUN
cet-13158	131	25	method	method	NOUN
cet-13158	131	26	and	and	CCONJ
cet-13158	131	27	different	different	ADJ
cet-13158	131	28	mixing	mixing	NOUN
cet-13158	131	29	models	model	NOUN
cet-13158	131	30	,	,	PUNCT
cet-13158	131	31	chemical	chemical	NOUN
cet-13158	131	32	engineering	engineering	NOUN
cet-13158	131	33	and	and	CCONJ
cet-13158	131	34	processing	processing	NOUN
cet-13158	131	35	process	process	NOUN
cet-13158	131	36	intensification	intensification	NOUN
cet-13158	131	37	,	,	PUNCT
cet-13158	131	38	181	181	NUM
cet-13158	131	39	,	,	PUNCT
cet-13158	131	40	109134	109134	NUM
cet-13158	131	41	.	.	PUNCT
cet-13158	132	1	schaare	schaare	PROPN
cet-13158	132	2	l.	l.	PROPN
cet-13158	132	3	,	,	PUNCT
cet-13158	132	4	rave	rave	ADJ
cet-13158	132	5	a.	a.	NOUN
cet-13158	132	6	,	,	PUNCT
cet-13158	132	7	kuwertz	kuwertz	PROPN
cet-13158	132	8	r.	r.	PROPN
cet-13158	132	9	,	,	PUNCT
cet-13158	132	10	heck	heck	INTJ
cet-13158	132	11	j.	j.	PROPN
cet-13158	132	12	,	,	PUNCT
cet-13158	132	13	fieg	fieg	PROPN
cet-13158	132	14	g.	g.	PROPN
cet-13158	132	15	,	,	PUNCT
cet-13158	132	16	skiborowski	skiborowski	NOUN
cet-13158	132	17	m.	m.	NOUN
cet-13158	132	18	,	,	PUNCT
cet-13158	132	19	2021	2021	NUM
cet-13158	132	20	,	,	PUNCT
cet-13158	132	21	hydrodynamics	hydrodynamic	NOUN
cet-13158	132	22	,	,	PUNCT
cet-13158	132	23	heat	heat	NOUN
cet-13158	132	24	transfer	transfer	NOUN
cet-13158	132	25	,	,	PUNCT
cet-13158	132	26	and	and	CCONJ
cet-13158	132	27	mixing	mix	VERB
cet-13158	132	28	in	in	ADP
cet-13158	132	29	a	a	DET
cet-13158	132	30	millistructured	millistructured	ADJ
cet-13158	132	31	plate	plate	NOUN
cet-13158	132	32	reactor	reactor	NOUN
cet-13158	132	33	,	,	PUNCT
cet-13158	132	34	15th	15th	ADJ
cet-13158	132	35	international	international	ADJ
cet-13158	132	36	conference	conference	NOUN
cet-13158	132	37	on	on	ADP
cet-13158	132	38	chemical	chemical	NOUN
cet-13158	132	39	and	and	CCONJ
cet-13158	132	40	process	process	NOUN
cet-13158	132	41	engineering	engineering	NOUN
cet-13158	132	42	,	,	PUNCT
cet-13158	132	43	2021	2021	NUM
cet-13158	132	44	yu	yu	PROPN
cet-13158	132	45	h.	h.	PROPN
cet-13158	132	46	,	,	PUNCT
cet-13158	132	47	2018	2018	NUM
cet-13158	132	48	,	,	PUNCT
cet-13158	132	49	optimal	optimal	ADJ
cet-13158	132	50	experimental	experimental	ADJ
cet-13158	132	51	design	design	NOUN
cet-13158	132	52	and	and	CCONJ
cet-13158	132	53	its	its	PRON
cet-13158	132	54	applications	application	NOUN
cet-13158	132	55	to	to	ADP
cet-13158	132	56	biochemical	biochemical	ADJ
cet-13158	132	57	engineering	engineering	NOUN
cet-13158	132	58	systems	system	NOUN
cet-13158	132	59	,	,	PUNCT
cet-13158	132	60	phd	phd	NOUN
cet-13158	132	61	thesis	thesis	NOUN
cet-13158	132	62	,	,	PUNCT
cet-13158	132	63	university	university	NOUN
cet-13158	132	64	of	of	ADP
cet-13158	132	65	strathclyde	strathclyde	PROPN
cet-13158	132	66	.	.	PUNCT
cet-13158	133	1	480	480	NUM
cet-13158	133	2	117schaare.pdf	117schaare.pdf	NUM
cet-13158	133	3	intensification	intensification	NOUN
cet-13158	133	4	of	of	ADP
cet-13158	133	5	kinetic	kinetic	ADJ
cet-13158	133	6	studies	study	NOUN
cet-13158	133	7	for	for	ADP
cet-13158	133	8	a	a	DET
cet-13158	133	9	multi	multi	ADJ
cet-13158	133	10	-	-	ADJ
cet-13158	133	11	step	step	ADJ
cet-13158	133	12	reaction	reaction	NOUN
cet-13158	133	13	in	in	ADP
cet-13158	133	14	a	a	DET
cet-13158	133	15	milli	milli	ADJ
cet-13158	133	16	-	-	PUNCT
cet-13158	133	17	structured	structured	ADJ
cet-13158	133	18	plate	plate	NOUN
cet-13158	133	19	reactor	reactor	NOUN
cet-13158	133	20	by	by	ADP
cet-13158	133	21	using	use	VERB
cet-13158	133	22	model	model	NOUN
cet-13158	133	23	-	-	PUNCT
cet-13158	133	24	based	base	VERB
cet-13158	133	25	design	design	NOUN
cet-13158	133	26	of	of	ADP
cet-13158	133	27	experiments	experiment	NOUN