id	sid	tid	token	lemma	pos
cet-13799	1	1	cet	cet	PROPN
cet-13799	1	2	-	-	ADJ
cet-13799	1	3	vol	vol	NOUN
cet-13799	1	4	105	105	NUM
cet-13799	1	5	doi	doi	NOUN
cet-13799	1	6	:	:	PUNCT
cet-13799	1	7	10.3303	10.3303	NUM
cet-13799	1	8	/	/	SYM
cet-13799	1	9	cet23105061	cet23105061	NOUN
cet-13799	1	10	paper	paper	NOUN
cet-13799	1	11	received	receive	VERB
cet-13799	1	12	:	:	PUNCT
cet-13799	1	13	5	5	NUM
cet-13799	1	14	march	march	NOUN
cet-13799	1	15	2023	2023	NUM
cet-13799	1	16	;	;	PUNCT
cet-13799	1	17	revised	revise	VERB
cet-13799	1	18	:	:	PUNCT
cet-13799	1	19	5	5	NUM
cet-13799	1	20	may	may	PROPN
cet-13799	1	21	2023	2023	NUM
cet-13799	1	22	;	;	PUNCT
cet-13799	1	23	accepted	accept	VERB
cet-13799	1	24	:	:	PUNCT
cet-13799	1	25	9	9	NUM
cet-13799	1	26	july	july	PROPN
cet-13799	1	27	2023	2023	NUM
cet-13799	1	28	please	please	INTJ
cet-13799	1	29	cite	cite	VERB
cet-13799	1	30	this	this	DET
cet-13799	1	31	article	article	NOUN
cet-13799	1	32	as	as	ADP
cet-13799	1	33	:	:	PUNCT
cet-13799	1	34	imran	imran	PROPN
cet-13799	1	35	f.	f.	PROPN
cet-13799	1	36	,	,	PUNCT
cet-13799	1	37	lueck	lueck	PROPN
cet-13799	1	38	r.	r.	PROPN
cet-13799	1	39	,	,	PUNCT
cet-13799	1	40	jordan	jordan	PROPN
cet-13799	1	41	c.	c.	PROPN
cet-13799	1	42	,	,	PUNCT
cet-13799	1	43	herwig	herwig	PROPN
cet-13799	1	44	c.	c.	PROPN
cet-13799	1	45	,	,	PUNCT
cet-13799	1	46	harasek	harasek	PROPN
cet-13799	1	47	m.	m.	NOUN
cet-13799	1	48	,	,	PUNCT
cet-13799	1	49	2023	2023	NUM
cet-13799	1	50	,	,	PUNCT
cet-13799	1	51	a	a	DET
cet-13799	1	52	perspective	perspective	NOUN
cet-13799	1	53	on	on	ADP
cet-13799	1	54	the	the	DET
cet-13799	1	55	role	role	NOUN
cet-13799	1	56	of	of	ADP
cet-13799	1	57	digitalization	digitalization	NOUN
cet-13799	1	58	enablers	enabler	NOUN
cet-13799	1	59	in	in	ADP
cet-13799	1	60	sustainable	sustainable	ADJ
cet-13799	1	61	pharmaceutical	pharmaceutical	ADJ
cet-13799	1	62	manufacturing	manufacturing	NOUN
cet-13799	1	63	,	,	PUNCT
cet-13799	1	64	chemical	chemical	NOUN
cet-13799	1	65	engineering	engineering	NOUN
cet-13799	1	66	transactions	transaction	NOUN
cet-13799	1	67	,	,	PUNCT
cet-13799	1	68	105	105	NUM
cet-13799	1	69	,	,	PUNCT
cet-13799	1	70	361	361	NUM
cet-13799	1	71	-	-	SYM
cet-13799	1	72	366	366	NUM
cet-13799	1	73	doi:10.3303	doi:10.3303	NOUN
cet-13799	1	74	/	/	SYM
cet-13799	1	75	cet23105061	cet23105061	NOUN
cet-13799	1	76	chemical	chemical	NOUN
cet-13799	1	77	engineering	engineering	NOUN
cet-13799	1	78	transactions	transaction	NOUN
cet-13799	1	79	vol	vol	NOUN
cet-13799	1	80	.	.	PROPN
cet-13799	1	81	105	105	NUM
cet-13799	1	82	,	,	PUNCT
cet-13799	1	83	2023	2023	NUM
cet-13799	1	84	a	a	DET
cet-13799	1	85	publication	publication	NOUN
cet-13799	1	86	of	of	ADP
cet-13799	1	87	the	the	DET
cet-13799	1	88	italian	italian	ADJ
cet-13799	1	89	association	association	NOUN
cet-13799	1	90	of	of	ADP
cet-13799	1	91	chemical	chemical	PROPN
cet-13799	1	92	engineering	engineering	NOUN
cet-13799	1	93	online	online	ADV
cet-13799	1	94	at	at	ADP
cet-13799	1	95	www.cetjournal.it	www.cetjournal.it	PROPN
cet-13799	1	96	guest	guest	NOUN
cet-13799	1	97	editors	editor	NOUN
cet-13799	1	98	:	:	PUNCT
cet-13799	1	99	david	david	PROPN
cet-13799	1	100	bogle	bogle	PROPN
cet-13799	1	101	,	,	PUNCT
cet-13799	1	102	flavio	flavio	PROPN
cet-13799	1	103	manenti	manenti	PROPN
cet-13799	1	104	,	,	PUNCT
cet-13799	1	105	piero	piero	PROPN
cet-13799	1	106	salatino	salatino	PROPN
cet-13799	1	107	copyright	copyright	NOUN
cet-13799	1	108	©	©	PROPN
cet-13799	1	109	2023	2023	NUM
cet-13799	1	110	,	,	PUNCT
cet-13799	1	111	aidic	aidic	ADJ
cet-13799	1	112	servizi	servizi	PROPN
cet-13799	1	113	s.r.l	s.r.l	NOUN
cet-13799	1	114	.	.	PUNCT
cet-13799	2	1	isbn	isbn	PROPN
cet-13799	2	2	979	979	NUM
cet-13799	2	3	-	-	SYM
cet-13799	2	4	12	12	NUM
cet-13799	2	5	-	-	PUNCT
cet-13799	2	6	81206	81206	NUM
cet-13799	2	7	-	-	PUNCT
cet-13799	2	8	04	04	NUM
cet-13799	2	9	-	-	PUNCT
cet-13799	2	10	5	5	NUM
cet-13799	2	11	;	;	PUNCT
cet-13799	2	12	issn	issn	PROPN
cet-13799	2	13	2283	2283	NUM
cet-13799	2	14	-	-	SYM
cet-13799	2	15	9216	9216	NUM
cet-13799	2	16	a	a	DET
cet-13799	2	17	perspective	perspective	NOUN
cet-13799	2	18	on	on	ADP
cet-13799	2	19	the	the	DET
cet-13799	2	20	role	role	NOUN
cet-13799	2	21	of	of	ADP
cet-13799	2	22	digitalization	digitalization	NOUN
cet-13799	2	23	enablers	enabler	NOUN
cet-13799	2	24	in	in	ADP
cet-13799	2	25	sustainable	sustainable	ADJ
cet-13799	2	26	pharmaceutical	pharmaceutical	NOUN
cet-13799	2	27	manufacturing	manufacturing	NOUN
cet-13799	2	28	fatima	fatima	PROPN
cet-13799	2	29	imran	imran	PROPN
cet-13799	2	30	*	*	PROPN
cet-13799	2	31	,	,	PUNCT
cet-13799	2	32	rüdiger	rüdiger	ADJ
cet-13799	2	33	lück	lück	PROPN
cet-13799	2	34	,	,	PUNCT
cet-13799	2	35	christian	christian	PROPN
cet-13799	2	36	jordan	jordan	PROPN
cet-13799	2	37	,	,	PUNCT
cet-13799	2	38	christoph	christoph	PROPN
cet-13799	2	39	herwig	herwig	PROPN
cet-13799	2	40	,	,	PUNCT
cet-13799	2	41	michael	michael	PROPN
cet-13799	2	42	harasek	harasek	PROPN
cet-13799	2	43	institute	institute	PROPN
cet-13799	2	44	of	of	ADP
cet-13799	2	45	chemical	chemical	PROPN
cet-13799	2	46	,	,	PUNCT
cet-13799	2	47	environmental	environmental	ADJ
cet-13799	2	48	and	and	CCONJ
cet-13799	2	49	bioscience	bioscience	PROPN
cet-13799	2	50	engineering	engineering	NOUN
cet-13799	2	51	,	,	PUNCT
cet-13799	2	52	tu	tu	PROPN
cet-13799	2	53	wien	wien	PROPN
cet-13799	2	54	,	,	PUNCT
cet-13799	2	55	vienna	vienna	PROPN
cet-13799	2	56	,	,	PUNCT
cet-13799	2	57	austria	austria	PROPN
cet-13799	2	58	fatima.imran@tuwien.ac.at	fatima.imran@tuwien.ac.at	PROPN
cet-13799	2	59	due	due	ADP
cet-13799	2	60	to	to	ADP
cet-13799	2	61	the	the	DET
cet-13799	2	62	steady	steady	ADJ
cet-13799	2	63	rise	rise	NOUN
cet-13799	2	64	in	in	ADP
cet-13799	2	65	the	the	DET
cet-13799	2	66	implementation	implementation	NOUN
cet-13799	2	67	of	of	ADP
cet-13799	2	68	industry	industry	NOUN
cet-13799	2	69	4.0	4.0	NUM
cet-13799	2	70	concepts	concept	NOUN
cet-13799	2	71	in	in	ADP
cet-13799	2	72	chemical	chemical	NOUN
cet-13799	2	73	and	and	CCONJ
cet-13799	2	74	(	(	PUNCT
cet-13799	2	75	bio)pharmaceutical	bio)pharmaceutical	ADJ
cet-13799	2	76	industries	industry	NOUN
cet-13799	2	77	,	,	PUNCT
cet-13799	2	78	an	an	DET
cet-13799	2	79	essential	essential	ADJ
cet-13799	2	80	aspect	aspect	NOUN
cet-13799	2	81	of	of	ADP
cet-13799	2	82	transitioning	transition	VERB
cet-13799	2	83	pharmaceutical	pharmaceutical	ADJ
cet-13799	2	84	production	production	NOUN
cet-13799	2	85	towards	towards	ADP
cet-13799	2	86	sustainable	sustainable	ADJ
cet-13799	2	87	pharmaceutical	pharmaceutical	NOUN
cet-13799	2	88	manufacturing	manufacturing	NOUN
cet-13799	2	89	(	(	PUNCT
cet-13799	2	90	spm	spm	PROPN
cet-13799	2	91	)	)	PUNCT
cet-13799	2	92	is	be	AUX
cet-13799	2	93	the	the	DET
cet-13799	2	94	utilization	utilization	NOUN
cet-13799	2	95	of	of	ADP
cet-13799	2	96	digitalization	digitalization	NOUN
cet-13799	2	97	technologies	technology	NOUN
cet-13799	2	98	.	.	PUNCT
cet-13799	3	1	spm	spm	PROPN
cet-13799	3	2	involves	involve	VERB
cet-13799	3	3	the	the	DET
cet-13799	3	4	collaboration	collaboration	NOUN
cet-13799	3	5	of	of	ADP
cet-13799	3	6	a	a	DET
cet-13799	3	7	multitude	multitude	NOUN
cet-13799	3	8	of	of	ADP
cet-13799	3	9	different	different	ADJ
cet-13799	3	10	process	process	NOUN
cet-13799	3	11	engineering	engineering	NOUN
cet-13799	3	12	and	and	CCONJ
cet-13799	3	13	sustainability	sustainability	NOUN
cet-13799	3	14	-	-	PUNCT
cet-13799	3	15	oriented	orient	VERB
cet-13799	3	16	systems	system	NOUN
cet-13799	3	17	methodologies	methodology	NOUN
cet-13799	3	18	like	like	ADP
cet-13799	3	19	lifecycle	lifecycle	NOUN
cet-13799	3	20	assessment	assessment	NOUN
cet-13799	3	21	and	and	CCONJ
cet-13799	3	22	green	green	ADJ
cet-13799	3	23	metrics	metric	NOUN
cet-13799	3	24	.	.	PUNCT
cet-13799	4	1	keeping	keep	VERB
cet-13799	4	2	this	this	PRON
cet-13799	4	3	in	in	ADP
cet-13799	4	4	mind	mind	NOUN
cet-13799	4	5	,	,	PUNCT
cet-13799	4	6	this	this	DET
cet-13799	4	7	paper	paper	NOUN
cet-13799	4	8	aims	aim	VERB
cet-13799	4	9	to	to	PART
cet-13799	4	10	provide	provide	VERB
cet-13799	4	11	a	a	DET
cet-13799	4	12	concise	concise	ADJ
cet-13799	4	13	review	review	NOUN
cet-13799	4	14	of	of	ADP
cet-13799	4	15	critical	critical	ADJ
cet-13799	4	16	areas	area	NOUN
cet-13799	4	17	of	of	ADP
cet-13799	4	18	digitalization	digitalization	NOUN
cet-13799	4	19	aspects	aspect	NOUN
cet-13799	4	20	to	to	ADP
cet-13799	4	21	overcoming	overcome	VERB
cet-13799	4	22	the	the	DET
cet-13799	4	23	hurdles	hurdle	NOUN
cet-13799	4	24	towards	towards	ADP
cet-13799	4	25	sustainability	sustainability	NOUN
cet-13799	4	26	of	of	ADP
cet-13799	4	27	pharmaceutical	pharmaceutical	NOUN
cet-13799	4	28	processes	process	NOUN
cet-13799	4	29	:	:	PUNCT
cet-13799	4	30	process	process	NOUN
cet-13799	4	31	analytical	analytical	ADJ
cet-13799	4	32	technologies	technology	NOUN
cet-13799	4	33	(	(	PUNCT
cet-13799	4	34	pats	pat	NOUN
cet-13799	4	35	)	)	PUNCT
cet-13799	4	36	,	,	PUNCT
cet-13799	4	37	soft	soft	ADJ
cet-13799	4	38	sensors	sensor	NOUN
cet-13799	4	39	and	and	CCONJ
cet-13799	4	40	digital	digital	ADJ
cet-13799	4	41	twins	twin	NOUN
cet-13799	4	42	(	(	PUNCT
cet-13799	4	43	dts	dts	NOUN
cet-13799	4	44	)	)	PUNCT
cet-13799	4	45	.	.	PUNCT
cet-13799	5	1	these	these	DET
cet-13799	5	2	tools	tool	NOUN
cet-13799	5	3	enable	enable	VERB
cet-13799	5	4	manufacturing	manufacturing	NOUN
cet-13799	5	5	under	under	ADP
cet-13799	5	6	the	the	DET
cet-13799	5	7	quality	quality	NOUN
cet-13799	5	8	-	-	PUNCT
cet-13799	5	9	by	by	ADP
cet-13799	5	10	-	-	PUNCT
cet-13799	5	11	design	design	NOUN
cet-13799	5	12	(	(	PUNCT
cet-13799	5	13	qbd	qbd	NOUN
cet-13799	5	14	)	)	PUNCT
cet-13799	5	15	paradigm	paradigm	NOUN
cet-13799	5	16	,	,	PUNCT
cet-13799	5	17	prioritizing	prioritize	VERB
cet-13799	5	18	process	process	NOUN
cet-13799	5	19	and	and	CCONJ
cet-13799	5	20	product	product	NOUN
cet-13799	5	21	understanding	understanding	NOUN
cet-13799	5	22	and	and	CCONJ
cet-13799	5	23	yield	yield	NOUN
cet-13799	5	24	to	to	PART
cet-13799	5	25	reduce	reduce	VERB
cet-13799	5	26	the	the	DET
cet-13799	5	27	number	number	NOUN
cet-13799	5	28	of	of	ADP
cet-13799	5	29	tests	test	NOUN
cet-13799	5	30	,	,	PUNCT
cet-13799	5	31	resources	resource	NOUN
cet-13799	5	32	,	,	PUNCT
cet-13799	5	33	and	and	CCONJ
cet-13799	5	34	costs	cost	NOUN
cet-13799	5	35	in	in	ADP
cet-13799	5	36	the	the	DET
cet-13799	5	37	long	long	ADJ
cet-13799	5	38	run	run	NOUN
cet-13799	5	39	.	.	PUNCT
cet-13799	6	1	modernization	modernization	NOUN
cet-13799	6	2	through	through	ADP
cet-13799	6	3	dts	dt	NOUN
cet-13799	6	4	and	and	CCONJ
cet-13799	6	5	pat	pat	PROPN
cet-13799	6	6	requires	require	VERB
cet-13799	6	7	significant	significant	ADJ
cet-13799	6	8	data	datum	NOUN
cet-13799	6	9	exchange	exchange	NOUN
cet-13799	6	10	and	and	CCONJ
cet-13799	6	11	a	a	DET
cet-13799	6	12	fully	fully	ADV
cet-13799	6	13	realized	realize	VERB
cet-13799	6	14	data	datum	NOUN
cet-13799	6	15	management	management	NOUN
cet-13799	6	16	system	system	NOUN
cet-13799	6	17	.	.	PUNCT
cet-13799	7	1	successful	successful	ADJ
cet-13799	7	2	integration	integration	NOUN
cet-13799	7	3	of	of	ADP
cet-13799	7	4	digitalization	digitalization	NOUN
cet-13799	7	5	,	,	PUNCT
cet-13799	7	6	i4.0	i4.0	PROPN
cet-13799	7	7	,	,	PUNCT
cet-13799	7	8	and	and	CCONJ
cet-13799	7	9	lean	lean	ADJ
cet-13799	7	10	manufacturing	manufacturing	NOUN
cet-13799	7	11	concepts	concept	NOUN
cet-13799	7	12	have	have	AUX
cet-13799	7	13	been	be	AUX
cet-13799	7	14	found	find	VERB
cet-13799	7	15	to	to	PART
cet-13799	7	16	be	be	AUX
cet-13799	7	17	of	of	ADP
cet-13799	7	18	substantial	substantial	ADJ
cet-13799	7	19	advantage	advantage	NOUN
cet-13799	7	20	for	for	ADP
cet-13799	7	21	flexible	flexible	ADJ
cet-13799	7	22	supply	supply	NOUN
cet-13799	7	23	chains	chain	NOUN
cet-13799	7	24	and	and	CCONJ
cet-13799	7	25	continuous	continuous	ADJ
cet-13799	7	26	manufacturing	manufacturing	NOUN
cet-13799	7	27	,	,	PUNCT
cet-13799	7	28	higher	high	ADJ
cet-13799	7	29	efficiencies	efficiency	NOUN
cet-13799	7	30	,	,	PUNCT
cet-13799	7	31	and	and	CCONJ
cet-13799	7	32	productivity	productivity	NOUN
cet-13799	7	33	with	with	ADP
cet-13799	7	34	minimal	minimal	ADJ
cet-13799	7	35	waste	waste	NOUN
cet-13799	7	36	production	production	NOUN
cet-13799	7	37	.	.	PUNCT
cet-13799	8	1	the	the	DET
cet-13799	8	2	path	path	NOUN
cet-13799	8	3	to	to	ADP
cet-13799	8	4	utilizing	utilize	VERB
cet-13799	8	5	these	these	DET
cet-13799	8	6	tools	tool	NOUN
cet-13799	8	7	to	to	ADP
cet-13799	8	8	their	their	PRON
cet-13799	8	9	full	full	ADJ
cet-13799	8	10	potential	potential	NOUN
cet-13799	8	11	in	in	ADP
cet-13799	8	12	the	the	DET
cet-13799	8	13	pharmaceutical	pharmaceutical	NOUN
cet-13799	8	14	industry	industry	NOUN
cet-13799	8	15	is	be	AUX
cet-13799	8	16	closely	closely	ADV
cet-13799	8	17	examined	examine	VERB
cet-13799	8	18	for	for	ADP
cet-13799	8	19	application	application	NOUN
cet-13799	8	20	in	in	ADP
cet-13799	8	21	specific	specific	ADJ
cet-13799	8	22	processes	process	NOUN
cet-13799	8	23	and	and	CCONJ
cet-13799	8	24	products	product	NOUN
cet-13799	8	25	in	in	ADP
cet-13799	8	26	the	the	DET
cet-13799	8	27	future	future	NOUN
cet-13799	8	28	.	.	PUNCT
cet-13799	9	1	1	1	X
cet-13799	9	2	.	.	X
cet-13799	9	3	introduction	introduction	NOUN
cet-13799	9	4	industry	industry	NOUN
cet-13799	9	5	4.0	4.0	NUM
cet-13799	9	6	(	(	PUNCT
cet-13799	9	7	i4.0	i4.0	PROPN
cet-13799	9	8	)	)	PUNCT
cet-13799	9	9	,	,	PUNCT
cet-13799	9	10	and	and	CCONJ
cet-13799	9	11	its	its	PRON
cet-13799	9	12	concepts	concept	NOUN
cet-13799	9	13	applied	apply	VERB
cet-13799	9	14	to	to	ADP
cet-13799	9	15	the	the	DET
cet-13799	9	16	pharmaceutical	pharmaceutical	NOUN
cet-13799	9	17	sector	sector	NOUN
cet-13799	9	18	,	,	PUNCT
cet-13799	9	19	pharma	pharma	PROPN
cet-13799	9	20	4.0	4.0	NUM
cet-13799	9	21	,	,	PUNCT
cet-13799	9	22	is	be	AUX
cet-13799	9	23	considered	consider	VERB
cet-13799	9	24	the	the	DET
cet-13799	9	25	next	next	ADJ
cet-13799	9	26	stage	stage	NOUN
cet-13799	9	27	of	of	ADP
cet-13799	9	28	the	the	DET
cet-13799	9	29	continuing	continue	VERB
cet-13799	9	30	industrial	industrial	ADJ
cet-13799	9	31	revolution	revolution	NOUN
cet-13799	9	32	that	that	PRON
cet-13799	9	33	started	start	VERB
cet-13799	9	34	with	with	ADP
cet-13799	9	35	mechanical	mechanical	ADJ
cet-13799	9	36	production	production	NOUN
cet-13799	9	37	in	in	ADP
cet-13799	9	38	the	the	DET
cet-13799	9	39	19th	19th	ADJ
cet-13799	9	40	century	century	NOUN
cet-13799	9	41	.	.	PUNCT
cet-13799	10	1	it	it	PRON
cet-13799	10	2	was	be	AUX
cet-13799	10	3	coined	coin	VERB
cet-13799	10	4	in	in	ADP
cet-13799	10	5	2011	2011	NUM
cet-13799	10	6	by	by	ADP
cet-13799	10	7	a	a	DET
cet-13799	10	8	german	german	ADJ
cet-13799	10	9	initiative	initiative	NOUN
cet-13799	10	10	with	with	ADP
cet-13799	10	11	the	the	DET
cet-13799	10	12	express	express	ADJ
cet-13799	10	13	aim	aim	NOUN
cet-13799	10	14	of	of	ADP
cet-13799	10	15	improving	improve	VERB
cet-13799	10	16	the	the	DET
cet-13799	10	17	capabilities	capability	NOUN
cet-13799	10	18	and	and	CCONJ
cet-13799	10	19	competitiveness	competitiveness	NOUN
cet-13799	10	20	of	of	ADP
cet-13799	10	21	production	production	NOUN
cet-13799	10	22	and	and	CCONJ
cet-13799	10	23	manufacturing	manufacturing	NOUN
cet-13799	10	24	in	in	ADP
cet-13799	10	25	germany	germany	PROPN
cet-13799	10	26	(	(	PUNCT
cet-13799	10	27	bmbf	bmbf	NOUN
cet-13799	10	28	,	,	PUNCT
cet-13799	10	29	2016	2016	NUM
cet-13799	10	30	)	)	PUNCT
cet-13799	10	31	.	.	PUNCT
cet-13799	11	1	industry	industry	NOUN
cet-13799	11	2	3.0	3.0	NUM
cet-13799	11	3	(	(	PUNCT
cet-13799	11	4	i3.0	i3.0	NOUN
cet-13799	11	5	)	)	PUNCT
cet-13799	11	6	is	be	AUX
cet-13799	11	7	driven	drive	VERB
cet-13799	11	8	by	by	ADP
cet-13799	11	9	the	the	DET
cet-13799	11	10	deployment	deployment	NOUN
cet-13799	11	11	of	of	ADP
cet-13799	11	12	rapid	rapid	ADJ
cet-13799	11	13	communication	communication	NOUN
cet-13799	11	14	technologies	technology	NOUN
cet-13799	11	15	,	,	PUNCT
cet-13799	11	16	wireless	wireless	ADJ
cet-13799	11	17	data	datum	NOUN
cet-13799	11	18	exchange	exchange	NOUN
cet-13799	11	19	,	,	PUNCT
cet-13799	11	20	networked	networked	ADJ
cet-13799	11	21	computing	computing	NOUN
cet-13799	11	22	,	,	PUNCT
cet-13799	11	23	and	and	CCONJ
cet-13799	11	24	new	new	ADJ
cet-13799	11	25	sensing	sense	VERB
cet-13799	11	26	technologies	technology	NOUN
cet-13799	11	27	.	.	PUNCT
cet-13799	12	1	while	while	SCONJ
cet-13799	12	2	generating	generate	VERB
cet-13799	12	3	large	large	ADJ
cet-13799	12	4	amounts	amount	NOUN
cet-13799	12	5	of	of	ADP
cet-13799	12	6	data	datum	NOUN
cet-13799	12	7	and	and	CCONJ
cet-13799	12	8	using	use	VERB
cet-13799	12	9	model	model	NOUN
cet-13799	12	10	-	-	PUNCT
cet-13799	12	11	based	base	VERB
cet-13799	12	12	methods	method	NOUN
cet-13799	12	13	in	in	ADP
cet-13799	12	14	production	production	NOUN
cet-13799	12	15	to	to	PART
cet-13799	12	16	assure	assure	VERB
cet-13799	12	17	product	product	NOUN
cet-13799	12	18	quality	quality	NOUN
cet-13799	12	19	,	,	PUNCT
cet-13799	12	20	the	the	DET
cet-13799	12	21	following	follow	VERB
cet-13799	12	22	steps	step	NOUN
cet-13799	12	23	towards	towards	ADP
cet-13799	12	24	i4.0	i4.0	PROPN
cet-13799	12	25	go	go	VERB
cet-13799	12	26	beyond	beyond	ADP
cet-13799	12	27	the	the	DET
cet-13799	12	28	pure	pure	ADJ
cet-13799	12	29	availability	availability	NOUN
cet-13799	12	30	of	of	ADP
cet-13799	12	31	complex	complex	ADJ
cet-13799	12	32	data	datum	NOUN
cet-13799	12	33	sets	set	NOUN
cet-13799	12	34	in	in	ADP
cet-13799	12	35	real	real	ADJ
cet-13799	12	36	-	-	PUNCT
cet-13799	12	37	time	time	NOUN
cet-13799	12	38	environments	environment	NOUN
cet-13799	12	39	.	.	PUNCT
cet-13799	13	1	i4.0	i4.0	PROPN
cet-13799	13	2	is	be	AUX
cet-13799	13	3	the	the	DET
cet-13799	13	4	imagination	imagination	NOUN
cet-13799	13	5	of	of	ADP
cet-13799	13	6	smart	smart	ADJ
cet-13799	13	7	factories	factory	NOUN
cet-13799	13	8	with	with	ADP
cet-13799	13	9	digital	digital	ADJ
cet-13799	13	10	twin	twin	NOUN
cet-13799	13	11	(	(	PUNCT
cet-13799	13	12	dt)-based	dt)-base	VERB
cet-13799	13	13	operational	operational	ADJ
cet-13799	13	14	decisions	decision	NOUN
cet-13799	13	15	along	along	ADP
cet-13799	13	16	the	the	DET
cet-13799	13	17	horizontal	horizontal	ADJ
cet-13799	13	18	and	and	CCONJ
cet-13799	13	19	vertical	vertical	ADJ
cet-13799	13	20	production	production	NOUN
cet-13799	13	21	chain	chain	NOUN
cet-13799	13	22	.	.	PUNCT
cet-13799	14	1	i4.0	i4.0	PROPN
cet-13799	14	2	encompasses	encompass	VERB
cet-13799	14	3	concepts	concept	NOUN
cet-13799	14	4	such	such	ADJ
cet-13799	14	5	as	as	ADP
cet-13799	14	6	the	the	DET
cet-13799	14	7	internet	internet	NOUN
cet-13799	14	8	of	of	ADP
cet-13799	14	9	things	thing	NOUN
cet-13799	14	10	(	(	PUNCT
cet-13799	14	11	iot	iot	NOUN
cet-13799	14	12	)	)	PUNCT
cet-13799	14	13	,	,	PUNCT
cet-13799	14	14	cyber	cyber	NOUN
cet-13799	14	15	-	-	PUNCT
cet-13799	14	16	physical	physical	ADJ
cet-13799	14	17	systems	system	NOUN
cet-13799	14	18	(	(	PUNCT
cet-13799	14	19	cps	cps	PROPN
cet-13799	14	20	)	)	PUNCT
cet-13799	14	21	(	(	PUNCT
cet-13799	14	22	arden	arden	PROPN
cet-13799	14	23	et	et	PROPN
cet-13799	14	24	al	al	PROPN
cet-13799	14	25	.	.	PROPN
cet-13799	14	26	,	,	PUNCT
cet-13799	14	27	2021	2021	NUM
cet-13799	14	28	)	)	PUNCT
cet-13799	14	29	,	,	PUNCT
cet-13799	14	30	and	and	CCONJ
cet-13799	14	31	cloud	cloud	NOUN
cet-13799	14	32	computing	computing	NOUN
cet-13799	14	33	to	to	PART
cet-13799	14	34	improve	improve	VERB
cet-13799	14	35	the	the	DET
cet-13799	14	36	economic	economic	ADJ
cet-13799	14	37	and	and	CCONJ
cet-13799	14	38	environmental	environmental	ADJ
cet-13799	14	39	sustainability	sustainability	NOUN
cet-13799	14	40	of	of	ADP
cet-13799	14	41	production	production	NOUN
cet-13799	14	42	processes	process	NOUN
cet-13799	14	43	(	(	PUNCT
cet-13799	14	44	steinwandter	steinwandter	NOUN
cet-13799	14	45	et	et	PROPN
cet-13799	14	46	al	al	PROPN
cet-13799	14	47	.	.	PROPN
cet-13799	14	48	,	,	PUNCT
cet-13799	14	49	2019	2019	NUM
cet-13799	14	50	)	)	PUNCT
cet-13799	14	51	.	.	PUNCT
cet-13799	15	1	technology	technology	NOUN
cet-13799	15	2	introduced	introduce	VERB
cet-13799	15	3	and	and	CCONJ
cet-13799	15	4	applied	apply	VERB
cet-13799	15	5	based	base	VERB
cet-13799	15	6	on	on	ADP
cet-13799	15	7	such	such	ADJ
cet-13799	15	8	concepts	concept	NOUN
cet-13799	15	9	requires	require	VERB
cet-13799	15	10	the	the	DET
cet-13799	15	11	integration	integration	NOUN
cet-13799	15	12	of	of	ADP
cet-13799	15	13	machinery	machinery	NOUN
cet-13799	15	14	essential	essential	ADJ
cet-13799	15	15	for	for	ADP
cet-13799	15	16	manufacturing	manufacture	VERB
cet-13799	15	17	into	into	ADP
cet-13799	15	18	a	a	DET
cet-13799	15	19	processing	processing	NOUN
cet-13799	15	20	unit	unit	NOUN
cet-13799	15	21	.	.	PUNCT
cet-13799	16	1	this	this	PRON
cet-13799	16	2	leads	lead	VERB
cet-13799	16	3	to	to	ADP
cet-13799	16	4	several	several	ADJ
cet-13799	16	5	favourable	favourable	ADJ
cet-13799	16	6	qualities	quality	NOUN
cet-13799	16	7	such	such	ADJ
cet-13799	16	8	as	as	ADP
cet-13799	16	9	high	high	ADJ
cet-13799	16	10	adaptability	adaptability	NOUN
cet-13799	16	11	and	and	CCONJ
cet-13799	16	12	accessibility	accessibility	NOUN
cet-13799	16	13	,	,	PUNCT
cet-13799	16	14	high	high	ADJ
cet-13799	16	15	accuracy	accuracy	NOUN
cet-13799	16	16	and	and	CCONJ
cet-13799	16	17	efficiency	efficiency	NOUN
cet-13799	16	18	of	of	ADP
cet-13799	16	19	the	the	DET
cet-13799	16	20	controlled	control	VERB
cet-13799	16	21	machines	machine	NOUN
cet-13799	16	22	and	and	CCONJ
cet-13799	16	23	operations	operation	NOUN
cet-13799	16	24	(	(	PUNCT
cet-13799	16	25	kamble	kamble	PROPN
cet-13799	16	26	et	et	PROPN
cet-13799	16	27	al	al	PROPN
cet-13799	16	28	.	.	PROPN
cet-13799	16	29	,	,	PUNCT
cet-13799	16	30	2018	2018	NUM
cet-13799	16	31	)	)	PUNCT
cet-13799	16	32	,	,	PUNCT
cet-13799	16	33	higher	high	ADJ
cet-13799	16	34	and	and	CCONJ
cet-13799	16	35	more	more	ADV
cet-13799	16	36	consistent	consistent	ADJ
cet-13799	16	37	product	product	NOUN
cet-13799	16	38	qualities	quality	NOUN
cet-13799	16	39	,	,	PUNCT
cet-13799	16	40	and	and	CCONJ
cet-13799	16	41	a	a	DET
cet-13799	16	42	more	more	ADV
cet-13799	16	43	efficient	efficient	ADJ
cet-13799	16	44	method	method	NOUN
cet-13799	16	45	towards	towards	ADP
cet-13799	16	46	scale	scale	NOUN
cet-13799	16	47	-	-	PUNCT
cet-13799	16	48	up	up	NOUN
cet-13799	16	49	and	and	CCONJ
cet-13799	16	50	a	a	DET
cet-13799	16	51	larger	large	ADJ
cet-13799	16	52	scale	scale	NOUN
cet-13799	16	53	of	of	ADP
cet-13799	16	54	operations	operation	NOUN
cet-13799	16	55	(	(	PUNCT
cet-13799	16	56	destro	destro	NOUN
cet-13799	16	57	and	and	CCONJ
cet-13799	16	58	barolo	barolo	NOUN
cet-13799	16	59	,	,	PUNCT
cet-13799	16	60	2022	2022	NUM
cet-13799	16	61	)	)	PUNCT
cet-13799	16	62	.	.	PUNCT
cet-13799	17	1	implementing	implement	VERB
cet-13799	17	2	i3.0	i3.0	ADJ
cet-13799	17	3	concepts	concept	NOUN
cet-13799	17	4	such	such	ADJ
cet-13799	17	5	as	as	ADP
cet-13799	17	6	continuous	continuous	ADJ
cet-13799	17	7	manufacturing	manufacturing	NOUN
cet-13799	17	8	,	,	PUNCT
cet-13799	17	9	quality	quality	NOUN
cet-13799	17	10	-	-	PUNCT
cet-13799	17	11	by	by	ADP
cet-13799	17	12	-	-	PUNCT
cet-13799	17	13	design	design	NOUN
cet-13799	17	14	(	(	PUNCT
cet-13799	17	15	qbd	qbd	NOUN
cet-13799	17	16	)	)	PUNCT
cet-13799	17	17	strategies	strategy	NOUN
cet-13799	17	18	,	,	PUNCT
cet-13799	17	19	process	process	NOUN
cet-13799	17	20	analytical	analytical	ADJ
cet-13799	17	21	technologies	technology	NOUN
cet-13799	17	22	(	(	PUNCT
cet-13799	17	23	pat	pat	NOUN
cet-13799	17	24	)	)	PUNCT
cet-13799	17	25	tools	tool	NOUN
cet-13799	17	26	,	,	PUNCT
cet-13799	17	27	and	and	CCONJ
cet-13799	17	28	dts	dts	NOUN
cet-13799	17	29	(	(	PUNCT
cet-13799	17	30	arden	arden	PROPN
cet-13799	17	31	et	et	PROPN
cet-13799	17	32	al	al	PROPN
cet-13799	17	33	.	.	PROPN
cet-13799	17	34	,	,	PUNCT
cet-13799	17	35	2021	2021	NUM
cet-13799	17	36	)	)	PUNCT
cet-13799	17	37	,	,	PUNCT
cet-13799	17	38	together	together	ADV
cet-13799	17	39	with	with	ADP
cet-13799	17	40	data	datum	NOUN
cet-13799	17	41	storage	storage	NOUN
cet-13799	17	42	technology	technology	NOUN
cet-13799	17	43	,	,	PUNCT
cet-13799	17	44	will	will	AUX
cet-13799	17	45	enable	enable	VERB
cet-13799	17	46	the	the	DET
cet-13799	17	47	pharmaceutical	pharmaceutical	ADJ
cet-13799	17	48	industry	industry	NOUN
cet-13799	17	49	to	to	PART
cet-13799	17	50	evolve	evolve	VERB
cet-13799	17	51	towards	towards	ADP
cet-13799	17	52	the	the	DET
cet-13799	17	53	widespread	widespread	ADJ
cet-13799	17	54	implementation	implementation	NOUN
cet-13799	17	55	of	of	ADP
cet-13799	17	56	i4.0	i4.0	PROPN
cet-13799	17	57	.	.	PUNCT
cet-13799	18	1	it	it	PRON
cet-13799	18	2	is	be	AUX
cet-13799	18	3	also	also	ADV
cet-13799	18	4	,	,	PUNCT
cet-13799	18	5	however	however	ADV
cet-13799	18	6	,	,	PUNCT
cet-13799	18	7	necessary	necessary	ADJ
cet-13799	18	8	to	to	PART
cet-13799	18	9	provide	provide	VERB
cet-13799	18	10	context	context	NOUN
cet-13799	18	11	to	to	ADP
cet-13799	18	12	the	the	DET
cet-13799	18	13	application	application	NOUN
cet-13799	18	14	of	of	ADP
cet-13799	18	15	such	such	ADJ
cet-13799	18	16	concepts	concept	NOUN
cet-13799	18	17	and	and	CCONJ
cet-13799	18	18	technologies	technology	NOUN
cet-13799	18	19	.	.	PUNCT
cet-13799	19	1	this	this	DET
cet-13799	19	2	paper	paper	NOUN
cet-13799	19	3	aims	aim	VERB
cet-13799	19	4	to	to	PART
cet-13799	19	5	examine	examine	VERB
cet-13799	19	6	these	these	DET
cet-13799	19	7	concepts	concept	NOUN
cet-13799	19	8	regarding	regard	VERB
cet-13799	19	9	the	the	DET
cet-13799	19	10	sustainability	sustainability	NOUN
cet-13799	19	11	of	of	ADP
cet-13799	19	12	pharmaceutical	pharmaceutical	ADJ
cet-13799	19	13	production	production	NOUN
cet-13799	19	14	.	.	PUNCT
cet-13799	20	1	over	over	ADP
cet-13799	20	2	the	the	DET
cet-13799	20	3	years	year	NOUN
cet-13799	20	4	,	,	PUNCT
cet-13799	20	5	there	there	PRON
cet-13799	20	6	has	have	AUX
cet-13799	20	7	been	be	AUX
cet-13799	20	8	a	a	DET
cet-13799	20	9	significant	significant	ADJ
cet-13799	20	10	trend	trend	NOUN
cet-13799	20	11	toward	toward	ADP
cet-13799	20	12	the	the	DET
cet-13799	20	13	investigation	investigation	NOUN
cet-13799	20	14	of	of	ADP
cet-13799	20	15	how	how	SCONJ
cet-13799	20	16	sustainable	sustainable	ADJ
cet-13799	20	17	a	a	DET
cet-13799	20	18	production	production	NOUN
cet-13799	20	19	process	process	NOUN
cet-13799	20	20	is	be	AUX
cet-13799	20	21	.	.	PUNCT
cet-13799	21	1	this	this	DET
cet-13799	21	2	trend	trend	NOUN
cet-13799	21	3	is	be	AUX
cet-13799	21	4	the	the	DET
cet-13799	21	5	catalyst	catalyst	NOUN
cet-13799	21	6	for	for	ADP
cet-13799	21	7	a	a	DET
cet-13799	21	8	‘	'	PUNCT
cet-13799	21	9	greener	green	ADJ
cet-13799	21	10	’	'	PUNCT
cet-13799	21	11	mindset	mindset	NOUN
cet-13799	21	12	and	and	CCONJ
cet-13799	21	13	a	a	DET
cet-13799	21	14	lifecycle	lifecycle	NOUN
cet-13799	21	15	analysis	analysis	NOUN
cet-13799	21	16	approach	approach	NOUN
cet-13799	21	17	toward	toward	ADP
cet-13799	21	18	producing	produce	VERB
cet-13799	21	19	active	active	ADJ
cet-13799	21	20	361	361	NUM
cet-13799	21	21	pharmacological	pharmacological	ADJ
cet-13799	21	22	ingredients	ingredient	NOUN
cet-13799	21	23	.	.	PUNCT
cet-13799	22	1	this	this	DET
cet-13799	22	2	review	review	NOUN
cet-13799	22	3	examined	examine	VERB
cet-13799	22	4	the	the	DET
cet-13799	22	5	combination	combination	NOUN
cet-13799	22	6	of	of	ADP
cet-13799	22	7	i3.0	i3.0	NOUN
cet-13799	22	8	and	and	CCONJ
cet-13799	22	9	i4.0	i4.0	ADJ
cet-13799	22	10	concepts	concept	NOUN
cet-13799	22	11	in	in	ADP
cet-13799	22	12	the	the	DET
cet-13799	22	13	broader	broad	ADJ
cet-13799	22	14	context	context	NOUN
cet-13799	22	15	of	of	ADP
cet-13799	22	16	sustainability	sustainability	NOUN
cet-13799	22	17	.	.	PUNCT
cet-13799	23	1	additionally	additionally	ADV
cet-13799	23	2	,	,	PUNCT
cet-13799	23	3	the	the	DET
cet-13799	23	4	challenges	challenge	NOUN
cet-13799	23	5	and	and	CCONJ
cet-13799	23	6	hurdles	hurdle	NOUN
cet-13799	23	7	of	of	ADP
cet-13799	23	8	adopting	adopt	VERB
cet-13799	23	9	the	the	DET
cet-13799	23	10	concepts	concept	NOUN
cet-13799	23	11	listed	list	VERB
cet-13799	23	12	above	above	ADV
cet-13799	23	13	by	by	ADP
cet-13799	23	14	the	the	DET
cet-13799	23	15	industries	industry	NOUN
cet-13799	23	16	in	in	ADP
cet-13799	23	17	the	the	DET
cet-13799	23	18	pharmaceutical	pharmaceutical	ADJ
cet-13799	23	19	sector	sector	NOUN
cet-13799	23	20	are	be	AUX
cet-13799	23	21	discussed	discuss	VERB
cet-13799	23	22	.	.	PUNCT
cet-13799	24	1	2	2	X
cet-13799	24	2	.	.	X
cet-13799	24	3	review	review	NOUN
cet-13799	24	4	methods	method	NOUN
cet-13799	24	5	a	a	DET
cet-13799	24	6	keyword	keyword	NOUN
cet-13799	24	7	search	search	NOUN
cet-13799	24	8	of	of	ADP
cet-13799	24	9	the	the	DET
cet-13799	24	10	following	following	NOUN
cet-13799	24	11	was	be	AUX
cet-13799	24	12	carried	carry	VERB
cet-13799	24	13	out	out	ADP
cet-13799	24	14	on	on	ADP
cet-13799	24	15	the	the	DET
cet-13799	24	16	scopus	scopus	NOUN
cet-13799	24	17	and	and	CCONJ
cet-13799	24	18	elsevier	elsevier	NOUN
cet-13799	24	19	databases	database	NOUN
cet-13799	24	20	:	:	PUNCT
cet-13799	24	21	sustainable	sustainable	ADJ
cet-13799	24	22	pharmaceutical	pharmaceutical	NOUN
cet-13799	24	23	manufacturing	manufacturing	NOUN
cet-13799	24	24	(	(	PUNCT
cet-13799	24	25	spm	spm	PROPN
cet-13799	24	26	)	)	PUNCT
cet-13799	24	27	,	,	PUNCT
cet-13799	24	28	process	process	NOUN
cet-13799	24	29	intensification	intensification	NOUN
cet-13799	24	30	,	,	PUNCT
cet-13799	24	31	green	green	ADJ
cet-13799	24	32	metrics	metric	NOUN
cet-13799	24	33	,	,	PUNCT
cet-13799	24	34	continuous	continuous	ADJ
cet-13799	24	35	biomanufacturing	biomanufacturing	NOUN
cet-13799	24	36	(	(	PUNCT
cet-13799	24	37	cbm	cbm	PROPN
cet-13799	24	38	)	)	PUNCT
cet-13799	24	39	,	,	PUNCT
cet-13799	24	40	digitalization	digitalization	NOUN
cet-13799	24	41	&	&	CCONJ
cet-13799	24	42	i4.0	i4.0	PROPN
cet-13799	24	43	,	,	PUNCT
cet-13799	24	44	batch	batch	NOUN
cet-13799	24	45	-	-	PUNCT
cet-13799	24	46	to	to	ADP
cet-13799	24	47	-	-	PUNCT
cet-13799	24	48	continuous	continuous	ADJ
cet-13799	24	49	process	process	NOUN
cet-13799	24	50	operation	operation	NOUN
cet-13799	24	51	,	,	PUNCT
cet-13799	24	52	dt	dt	PUNCT
cet-13799	24	53	lifecycle	lifecycle	NOUN
cet-13799	24	54	,	,	PUNCT
cet-13799	24	55	model	model	NOUN
cet-13799	24	56	-	-	PUNCT
cet-13799	24	57	assisted	assist	VERB
cet-13799	24	58	design	design	NOUN
cet-13799	24	59	of	of	ADP
cet-13799	24	60	experiments	experiment	NOUN
cet-13799	24	61	(	(	PUNCT
cet-13799	24	62	doe	doe	NOUN
cet-13799	24	63	)	)	PUNCT
cet-13799	24	64	,	,	PUNCT
cet-13799	24	65	advanced	advanced	ADJ
cet-13799	24	66	process	process	NOUN
cet-13799	24	67	control	control	NOUN
cet-13799	24	68	,	,	PUNCT
cet-13799	24	69	process	process	NOUN
cet-13799	24	70	monitoring	monitoring	NOUN
cet-13799	24	71	&	&	CCONJ
cet-13799	24	72	control	control	PROPN
cet-13799	24	73	.	.	PUNCT
cet-13799	25	1	this	this	DET
cet-13799	25	2	research	research	NOUN
cet-13799	25	3	illustrated	illustrate	VERB
cet-13799	25	4	the	the	DET
cet-13799	25	5	most	most	ADV
cet-13799	25	6	important	important	ADJ
cet-13799	25	7	themes	theme	NOUN
cet-13799	25	8	that	that	PRON
cet-13799	25	9	are	be	AUX
cet-13799	25	10	outlined	outline	VERB
cet-13799	25	11	below	below	ADV
cet-13799	25	12	.	.	PUNCT
cet-13799	26	1	3	3	X
cet-13799	26	2	.	.	X
cet-13799	26	3	green	green	ADJ
cet-13799	26	4	metrics	metric	NOUN
cet-13799	26	5	for	for	ADP
cet-13799	26	6	sustainability	sustainability	NOUN
cet-13799	26	7	evaluation	evaluation	NOUN
cet-13799	26	8	to	to	PART
cet-13799	26	9	quantify	quantify	VERB
cet-13799	26	10	the	the	DET
cet-13799	26	11	‘	'	PUNCT
cet-13799	26	12	greenness	greenness	NOUN
cet-13799	26	13	’	'	PUNCT
cet-13799	26	14	or	or	CCONJ
cet-13799	26	15	the	the	DET
cet-13799	26	16	sustainability	sustainability	NOUN
cet-13799	26	17	of	of	ADP
cet-13799	26	18	spm	spm	PROPN
cet-13799	26	19	processes	process	NOUN
cet-13799	26	20	(	(	PUNCT
cet-13799	26	21	or	or	CCONJ
cet-13799	26	22	processes	process	NOUN
cet-13799	26	23	in	in	ADP
cet-13799	26	24	general	general	ADJ
cet-13799	26	25	)	)	PUNCT
cet-13799	26	26	,	,	PUNCT
cet-13799	26	27	various	various	ADJ
cet-13799	26	28	metrics	metric	NOUN
cet-13799	26	29	/	/	SYM
cet-13799	26	30	assessments	assessment	NOUN
cet-13799	26	31	are	be	AUX
cet-13799	26	32	necessary	necessary	ADJ
cet-13799	26	33	.	.	PUNCT
cet-13799	27	1	these	these	DET
cet-13799	27	2	metrics	metric	NOUN
cet-13799	27	3	must	must	AUX
cet-13799	27	4	be	be	AUX
cet-13799	27	5	simple	simple	ADJ
cet-13799	27	6	to	to	AUX
cet-13799	27	7	use	use	VERB
cet-13799	27	8	and	and	CCONJ
cet-13799	27	9	apply	apply	VERB
cet-13799	27	10	,	,	PUNCT
cet-13799	27	11	clearly	clearly	ADV
cet-13799	27	12	defined	define	VERB
cet-13799	27	13	,	,	PUNCT
cet-13799	27	14	and	and	CCONJ
cet-13799	27	15	integral	integral	ADJ
cet-13799	27	16	to	to	ADP
cet-13799	27	17	the	the	DET
cet-13799	27	18	decision	decision	NOUN
cet-13799	27	19	-	-	PUNCT
cet-13799	27	20	making	making	NOUN
cet-13799	27	21	of	of	ADP
cet-13799	27	22	the	the	DET
cet-13799	27	23	project	project	NOUN
cet-13799	27	24	and	and	CCONJ
cet-13799	27	25	manufacturing	manufacturing	NOUN
cet-13799	27	26	process	process	NOUN
cet-13799	27	27	.	.	PUNCT
cet-13799	28	1	many	many	ADJ
cet-13799	28	2	different	different	ADJ
cet-13799	28	3	metrics	metric	NOUN
cet-13799	28	4	have	have	AUX
cet-13799	28	5	been	be	AUX
cet-13799	28	6	developed	develop	VERB
cet-13799	28	7	to	to	PART
cet-13799	28	8	be	be	AUX
cet-13799	28	9	able	able	ADJ
cet-13799	28	10	to	to	PART
cet-13799	28	11	measure	measure	VERB
cet-13799	28	12	the	the	DET
cet-13799	28	13	‘	'	PUNCT
cet-13799	28	14	greenness	greenness	NOUN
cet-13799	28	15	’	'	PUNCT
cet-13799	28	16	of	of	ADP
cet-13799	28	17	a	a	DET
cet-13799	28	18	process	process	NOUN
cet-13799	28	19	.	.	PUNCT
cet-13799	29	1	different	different	ADJ
cet-13799	29	2	metrics	metric	NOUN
cet-13799	29	3	consider	consider	VERB
cet-13799	29	4	other	other	ADJ
cet-13799	29	5	aspects	aspect	NOUN
cet-13799	29	6	of	of	ADP
cet-13799	29	7	a	a	DET
cet-13799	29	8	process	process	NOUN
cet-13799	29	9	,	,	PUNCT
cet-13799	29	10	whether	whether	SCONJ
cet-13799	29	11	it	it	PRON
cet-13799	29	12	be	be	VERB
cet-13799	29	13	the	the	DET
cet-13799	29	14	amount	amount	NOUN
cet-13799	29	15	of	of	ADP
cet-13799	29	16	water	water	NOUN
cet-13799	29	17	,	,	PUNCT
cet-13799	29	18	solvents	solvent	NOUN
cet-13799	29	19	,	,	PUNCT
cet-13799	29	20	or	or	CCONJ
cet-13799	29	21	reagents	reagent	NOUN
cet-13799	29	22	used	use	VERB
cet-13799	29	23	or	or	CCONJ
cet-13799	29	24	energy	energy	NOUN
cet-13799	29	25	consumption	consumption	NOUN
cet-13799	29	26	,	,	PUNCT
cet-13799	29	27	or	or	CCONJ
cet-13799	29	28	greenhouse	greenhouse	NOUN
cet-13799	29	29	gas	gas	NOUN
cet-13799	29	30	emissions	emission	NOUN
cet-13799	29	31	.	.	PUNCT
cet-13799	30	1	the	the	DET
cet-13799	30	2	sustainability	sustainability	NOUN
cet-13799	30	3	of	of	ADP
cet-13799	30	4	an	an	DET
cet-13799	30	5	spm	spm	NOUN
cet-13799	30	6	process	process	NOUN
cet-13799	30	7	is	be	AUX
cet-13799	30	8	evaluated	evaluate	VERB
cet-13799	30	9	by	by	ADP
cet-13799	30	10	analyzing	analyze	VERB
cet-13799	30	11	its	its	PRON
cet-13799	30	12	environmental	environmental	ADJ
cet-13799	30	13	footprint	footprint	NOUN
cet-13799	30	14	.	.	PUNCT
cet-13799	31	1	to	to	PART
cet-13799	31	2	compare	compare	VERB
cet-13799	31	3	different	different	ADJ
cet-13799	31	4	processes	process	NOUN
cet-13799	31	5	,	,	PUNCT
cet-13799	31	6	green	green	ADJ
cet-13799	31	7	metrics	metric	NOUN
cet-13799	31	8	have	have	AUX
cet-13799	31	9	been	be	AUX
cet-13799	31	10	introduced	introduce	VERB
cet-13799	31	11	to	to	PART
cet-13799	31	12	assess	assess	VERB
cet-13799	31	13	sustainability	sustainability	NOUN
cet-13799	31	14	in	in	ADP
cet-13799	31	15	numerical	numerical	ADJ
cet-13799	31	16	terms	term	NOUN
cet-13799	31	17	(	(	PUNCT
cet-13799	31	18	jimenez	jimenez	PROPN
cet-13799	31	19	-	-	PUNCT
cet-13799	31	20	gonzalez	gonzalez	PROPN
cet-13799	31	21	and	and	CCONJ
cet-13799	31	22	lund	lund	PROPN
cet-13799	31	23	,	,	PUNCT
cet-13799	31	24	2022	2022	NUM
cet-13799	31	25	)	)	PUNCT
cet-13799	31	26	.	.	PUNCT
cet-13799	32	1	standard	standard	ADJ
cet-13799	32	2	green	green	ADJ
cet-13799	32	3	metrics	metric	NOUN
cet-13799	32	4	include	include	VERB
cet-13799	32	5	the	the	DET
cet-13799	32	6	water	water	NOUN
cet-13799	32	7	related	relate	VERB
cet-13799	32	8	impact	impact	NOUN
cet-13799	32	9	of	of	ADP
cet-13799	32	10	energy	energy	NOUN
cet-13799	32	11	(	(	PUNCT
cet-13799	32	12	warien	warien	NOUN
cet-13799	32	13	)	)	PUNCT
cet-13799	32	14	(	(	PUNCT
cet-13799	32	15	cataldo	cataldo	PROPN
cet-13799	32	16	et	et	PROPN
cet-13799	32	17	al	al	PROPN
cet-13799	32	18	.	.	PROPN
cet-13799	32	19	,	,	PUNCT
cet-13799	32	20	2020	2020	NUM
cet-13799	32	21	)	)	PUNCT
cet-13799	32	22	,	,	PUNCT
cet-13799	32	23	environmental	environmental	ADJ
cet-13799	32	24	factor	factor	NOUN
cet-13799	32	25	(	(	PUNCT
cet-13799	32	26	e	e	NOUN
cet-13799	32	27	-	-	NOUN
cet-13799	32	28	factor	factor	NOUN
cet-13799	32	29	)	)	PUNCT
cet-13799	32	30	(	(	PUNCT
cet-13799	32	31	jimenez	jimenez	PROPN
cet-13799	32	32	-	-	PUNCT
cet-13799	32	33	gonzalez	gonzalez	PROPN
cet-13799	32	34	and	and	CCONJ
cet-13799	32	35	lund	lund	PROPN
cet-13799	32	36	,	,	PUNCT
cet-13799	32	37	2022	2022	NUM
cet-13799	32	38	)	)	PUNCT
cet-13799	32	39	and	and	CCONJ
cet-13799	32	40	process	process	NOUN
cet-13799	32	41	mass	mass	NOUN
cet-13799	32	42	intensity	intensity	NOUN
cet-13799	32	43	(	(	PUNCT
cet-13799	32	44	pmi	pmi	PROPN
cet-13799	32	45	)	)	PUNCT
cet-13799	32	46	(	(	PUNCT
cet-13799	32	47	jimenez	jimenez	PROPN
cet-13799	32	48	-	-	PUNCT
cet-13799	32	49	gonzalez	gonzalez	PROPN
cet-13799	32	50	and	and	CCONJ
cet-13799	32	51	lund	lund	PROPN
cet-13799	32	52	,	,	PUNCT
cet-13799	32	53	2022	2022	NUM
cet-13799	32	54	)	)	PUNCT
cet-13799	32	55	.	.	PUNCT
cet-13799	33	1	the	the	PRON
cet-13799	33	2	e	e	NOUN
cet-13799	33	3	-	-	NOUN
cet-13799	33	4	factor	factor	NOUN
cet-13799	33	5	is	be	AUX
cet-13799	33	6	defined	define	VERB
cet-13799	33	7	as	as	ADP
cet-13799	33	8	the	the	DET
cet-13799	33	9	mass	mass	NOUN
cet-13799	33	10	ratio	ratio	NOUN
cet-13799	33	11	of	of	ADP
cet-13799	33	12	waste	waste	NOUN
cet-13799	33	13	in	in	ADP
cet-13799	33	14	relation	relation	NOUN
cet-13799	33	15	to	to	ADP
cet-13799	33	16	a	a	DET
cet-13799	33	17	unit	unit	NOUN
cet-13799	33	18	mass	mass	NOUN
cet-13799	33	19	of	of	ADP
cet-13799	33	20	product	product	NOUN
cet-13799	33	21	.	.	PUNCT
cet-13799	34	1	another	another	DET
cet-13799	34	2	green	green	ADJ
cet-13799	34	3	metric	metric	NOUN
cet-13799	34	4	is	be	AUX
cet-13799	34	5	pmi	pmi	PROPN
cet-13799	34	6	,	,	PUNCT
cet-13799	34	7	which	which	PRON
cet-13799	34	8	describes	describe	VERB
cet-13799	34	9	the	the	DET
cet-13799	34	10	ratio	ratio	NOUN
cet-13799	34	11	between	between	ADP
cet-13799	34	12	the	the	DET
cet-13799	34	13	total	total	ADJ
cet-13799	34	14	mass	mass	NOUN
cet-13799	34	15	of	of	ADP
cet-13799	34	16	all	all	DET
cet-13799	34	17	materials	material	NOUN
cet-13799	34	18	processed	process	VERB
cet-13799	34	19	and	and	CCONJ
cet-13799	34	20	the	the	DET
cet-13799	34	21	mass	mass	NOUN
cet-13799	34	22	of	of	ADP
cet-13799	34	23	the	the	DET
cet-13799	34	24	product	product	NOUN
cet-13799	34	25	.	.	PUNCT
cet-13799	35	1	an	an	DET
cet-13799	35	2	extension	extension	NOUN
cet-13799	35	3	is	be	AUX
cet-13799	35	4	the	the	DET
cet-13799	35	5	warien	warien	NOUN
cet-13799	35	6	metric	metric	NOUN
cet-13799	35	7	,	,	PUNCT
cet-13799	35	8	which	which	PRON
cet-13799	35	9	relates	relate	VERB
cet-13799	35	10	co2	co2	NOUN
cet-13799	35	11	emissions	emission	NOUN
cet-13799	35	12	to	to	ADP
cet-13799	35	13	the	the	DET
cet-13799	35	14	unit	unit	NOUN
cet-13799	35	15	mass	mass	NOUN
cet-13799	35	16	of	of	ADP
cet-13799	35	17	the	the	DET
cet-13799	35	18	product	product	NOUN
cet-13799	35	19	.	.	PUNCT
cet-13799	36	1	in	in	ADP
cet-13799	36	2	addition	addition	NOUN
cet-13799	36	3	to	to	ADP
cet-13799	36	4	the	the	DET
cet-13799	36	5	actual	actual	ADJ
cet-13799	36	6	process	process	NOUN
cet-13799	36	7	emissions	emission	NOUN
cet-13799	36	8	,	,	PUNCT
cet-13799	36	9	warien	warien	NOUN
cet-13799	36	10	also	also	ADV
cet-13799	36	11	takes	take	VERB
cet-13799	36	12	into	into	ADP
cet-13799	36	13	account	account	NOUN
cet-13799	36	14	emissions	emission	NOUN
cet-13799	36	15	during	during	ADP
cet-13799	36	16	the	the	DET
cet-13799	36	17	production	production	NOUN
cet-13799	36	18	of	of	ADP
cet-13799	36	19	raw	raw	ADJ
cet-13799	36	20	materials	material	NOUN
cet-13799	36	21	(	(	PUNCT
cet-13799	36	22	e.g.	e.g.	ADV
cet-13799	36	23	purified	purified	ADJ
cet-13799	36	24	water	water	NOUN
cet-13799	36	25	)	)	PUNCT
cet-13799	36	26	.	.	PUNCT
cet-13799	37	1	the	the	DET
cet-13799	37	2	concepts	concept	NOUN
cet-13799	37	3	of	of	ADP
cet-13799	37	4	i4.0	i4.0	PROPN
cet-13799	37	5	are	be	AUX
cet-13799	37	6	posed	pose	VERB
cet-13799	37	7	to	to	PART
cet-13799	37	8	minimize	minimize	VERB
cet-13799	37	9	waste	waste	NOUN
cet-13799	37	10	and	and	CCONJ
cet-13799	37	11	prioritize	prioritize	VERB
cet-13799	37	12	resource	resource	NOUN
cet-13799	37	13	efficiency	efficiency	NOUN
cet-13799	37	14	and	and	CCONJ
cet-13799	37	15	thus	thus	ADV
cet-13799	37	16	lead	lead	VERB
cet-13799	37	17	to	to	ADP
cet-13799	37	18	a	a	DET
cet-13799	37	19	more	more	ADV
cet-13799	37	20	sustainable	sustainable	ADJ
cet-13799	37	21	production	production	NOUN
cet-13799	37	22	process	process	NOUN
cet-13799	37	23	and	and	CCONJ
cet-13799	37	24	chain	chain	NOUN
cet-13799	37	25	.	.	PUNCT
cet-13799	38	1	therefore	therefore	ADV
cet-13799	38	2	,	,	PUNCT
cet-13799	38	3	it	it	PRON
cet-13799	38	4	is	be	AUX
cet-13799	38	5	evident	evident	ADJ
cet-13799	38	6	that	that	SCONJ
cet-13799	38	7	an	an	DET
cet-13799	38	8	interdisciplinary	interdisciplinary	ADJ
cet-13799	38	9	connection	connection	NOUN
cet-13799	38	10	exists	exist	VERB
cet-13799	38	11	between	between	ADP
cet-13799	38	12	a	a	DET
cet-13799	38	13	lifecycle	lifecycle	NOUN
cet-13799	38	14	approach	approach	NOUN
cet-13799	38	15	and	and	CCONJ
cet-13799	38	16	the	the	DET
cet-13799	38	17	i4.0	i4.0	PROPN
cet-13799	38	18	concepts	concept	NOUN
cet-13799	38	19	outlined	outline	VERB
cet-13799	38	20	in	in	ADP
cet-13799	38	21	this	this	DET
cet-13799	38	22	paper	paper	NOUN
cet-13799	38	23	.	.	PUNCT
cet-13799	39	1	taking	take	VERB
cet-13799	39	2	this	this	PRON
cet-13799	39	3	into	into	ADP
cet-13799	39	4	account	account	NOUN
cet-13799	39	5	,	,	PUNCT
cet-13799	39	6	several	several	ADJ
cet-13799	39	7	tools	tool	NOUN
cet-13799	39	8	are	be	AUX
cet-13799	39	9	examined	examine	VERB
cet-13799	39	10	within	within	ADP
cet-13799	39	11	the	the	DET
cet-13799	39	12	scope	scope	NOUN
cet-13799	39	13	of	of	ADP
cet-13799	39	14	this	this	DET
cet-13799	39	15	work	work	NOUN
cet-13799	39	16	that	that	PRON
cet-13799	39	17	helps	help	VERB
cet-13799	39	18	pave	pave	VERB
cet-13799	39	19	the	the	DET
cet-13799	39	20	way	way	NOUN
cet-13799	39	21	toward	toward	ADP
cet-13799	39	22	sustainability	sustainability	NOUN
cet-13799	39	23	in	in	ADP
cet-13799	39	24	the	the	DET
cet-13799	39	25	pharmaceutical	pharmaceutical	ADJ
cet-13799	39	26	industry	industry	NOUN
cet-13799	39	27	.	.	PUNCT
cet-13799	40	1	4	4	X
cet-13799	40	2	.	.	X
cet-13799	40	3	the	the	DET
cet-13799	40	4	digitalization	digitalization	NOUN
cet-13799	40	5	enablers	enabler	VERB
cet-13799	40	6	4.1	4.1	NUM
cet-13799	40	7	process	process	NOUN
cet-13799	40	8	analytical	analytical	ADJ
cet-13799	40	9	technologies	technology	NOUN
cet-13799	40	10	(	(	PUNCT
cet-13799	40	11	pats	pat	NOUN
cet-13799	40	12	)	)	PUNCT
cet-13799	40	13	based	base	VERB
cet-13799	40	14	on	on	ADP
cet-13799	40	15	the	the	DET
cet-13799	40	16	review	review	NOUN
cet-13799	40	17	performed	perform	VERB
cet-13799	40	18	while	while	SCONJ
cet-13799	40	19	writing	write	VERB
cet-13799	40	20	and	and	CCONJ
cet-13799	40	21	collecting	collect	VERB
cet-13799	40	22	data	datum	NOUN
cet-13799	40	23	for	for	ADP
cet-13799	40	24	this	this	DET
cet-13799	40	25	work	work	NOUN
cet-13799	40	26	,	,	PUNCT
cet-13799	40	27	the	the	DET
cet-13799	40	28	application	application	NOUN
cet-13799	40	29	of	of	ADP
cet-13799	40	30	pats	pat	NOUN
cet-13799	40	31	was	be	AUX
cet-13799	40	32	found	find	VERB
cet-13799	40	33	to	to	PART
cet-13799	40	34	be	be	AUX
cet-13799	40	35	highly	highly	ADV
cet-13799	40	36	important	important	ADJ
cet-13799	40	37	towards	towards	ADP
cet-13799	40	38	integrating	integrate	VERB
cet-13799	40	39	more	more	ADJ
cet-13799	40	40	sustainability	sustainability	NOUN
cet-13799	40	41	into	into	ADP
cet-13799	40	42	the	the	DET
cet-13799	40	43	manufacture	manufacture	NOUN
cet-13799	40	44	of	of	ADP
cet-13799	40	45	pharmaceutical	pharmaceutical	NOUN
cet-13799	40	46	products	product	NOUN
cet-13799	40	47	.	.	PUNCT
cet-13799	41	1	regardless	regardless	ADV
cet-13799	41	2	of	of	ADP
cet-13799	41	3	whether	whether	SCONJ
cet-13799	41	4	a	a	DET
cet-13799	41	5	batch	batch	NOUN
cet-13799	41	6	or	or	CCONJ
cet-13799	41	7	a	a	DET
cet-13799	41	8	continuous	continuous	ADJ
cet-13799	41	9	mode	mode	NOUN
cet-13799	41	10	of	of	ADP
cet-13799	41	11	operations	operation	NOUN
cet-13799	41	12	is	be	AUX
cet-13799	41	13	applied	apply	VERB
cet-13799	41	14	,	,	PUNCT
cet-13799	41	15	a	a	DET
cet-13799	41	16	sophisticated	sophisticated	ADJ
cet-13799	41	17	method	method	NOUN
cet-13799	41	18	of	of	ADP
cet-13799	41	19	providing	provide	VERB
cet-13799	41	20	real	real	ADJ
cet-13799	41	21	-	-	PUNCT
cet-13799	41	22	time	time	NOUN
cet-13799	41	23	control	control	NOUN
cet-13799	41	24	and	and	CCONJ
cet-13799	41	25	monitoring	monitoring	NOUN
cet-13799	41	26	of	of	ADP
cet-13799	41	27	critical	critical	ADJ
cet-13799	41	28	quality	quality	NOUN
cet-13799	41	29	attributes	attribute	NOUN
cet-13799	41	30	(	(	PUNCT
cet-13799	41	31	cqas	cqas	NOUN
cet-13799	41	32	)	)	PUNCT
cet-13799	41	33	of	of	ADP
cet-13799	41	34	a	a	DET
cet-13799	41	35	product	product	NOUN
cet-13799	41	36	and	and	CCONJ
cet-13799	41	37	raw	raw	ADJ
cet-13799	41	38	material	material	NOUN
cet-13799	41	39	(	(	PUNCT
cet-13799	41	40	critical	critical	ADJ
cet-13799	41	41	raw	raw	ADJ
cet-13799	41	42	material	material	NOUN
cet-13799	41	43	attribute	attribute	NOUN
cet-13799	41	44	,	,	PUNCT
cet-13799	41	45	cma	cma	NOUN
cet-13799	41	46	)	)	PUNCT
cet-13799	41	47	and	and	CCONJ
cet-13799	41	48	critical	critical	ADJ
cet-13799	41	49	process	process	NOUN
cet-13799	41	50	parameters	parameter	NOUN
cet-13799	41	51	(	(	PUNCT
cet-13799	41	52	cpps	cpps	PROPN
cet-13799	41	53	)	)	PUNCT
cet-13799	41	54	that	that	PRON
cet-13799	41	55	directly	directly	ADV
cet-13799	41	56	correspond	correspond	VERB
cet-13799	41	57	with	with	ADP
cet-13799	41	58	a	a	DET
cet-13799	41	59	cqa	cqa	NOUN
cet-13799	41	60	of	of	ADP
cet-13799	41	61	the	the	DET
cet-13799	41	62	desired	desire	VERB
cet-13799	41	63	product	product	NOUN
cet-13799	41	64	(	(	PUNCT
cet-13799	41	65	gerzon	gerzon	PROPN
cet-13799	41	66	et	et	PROPN
cet-13799	41	67	al	al	PROPN
cet-13799	41	68	.	.	PROPN
cet-13799	41	69	,	,	PUNCT
cet-13799	41	70	2022	2022	NUM
cet-13799	41	71	)	)	PUNCT
cet-13799	41	72	are	be	AUX
cet-13799	41	73	necessary	necessary	ADJ
cet-13799	41	74	for	for	ADP
cet-13799	41	75	the	the	DET
cet-13799	41	76	digitalization	digitalization	NOUN
cet-13799	41	77	of	of	ADP
cet-13799	41	78	the	the	DET
cet-13799	41	79	process	process	NOUN
cet-13799	41	80	and	and	CCONJ
cet-13799	41	81	for	for	ADP
cet-13799	41	82	monitoring	monitor	VERB
cet-13799	41	83	product	product	NOUN
cet-13799	41	84	control	control	NOUN
cet-13799	41	85	and	and	CCONJ
cet-13799	41	86	output	output	NOUN
cet-13799	41	87	.	.	PUNCT
cet-13799	42	1	the	the	DET
cet-13799	42	2	properties	property	NOUN
cet-13799	42	3	of	of	ADP
cet-13799	42	4	a	a	DET
cet-13799	42	5	product	product	NOUN
cet-13799	42	6	in	in	ADP
cet-13799	42	7	the	the	DET
cet-13799	42	8	pharmaceutical	pharmaceutical	NOUN
cet-13799	42	9	industry	industry	NOUN
cet-13799	42	10	are	be	AUX
cet-13799	42	11	set	set	VERB
cet-13799	42	12	under	under	ADP
cet-13799	42	13	strict	strict	ADJ
cet-13799	42	14	regulations	regulation	NOUN
cet-13799	42	15	.	.	PUNCT
cet-13799	43	1	therefore	therefore	ADV
cet-13799	43	2	,	,	PUNCT
cet-13799	43	3	the	the	DET
cet-13799	43	4	application	application	NOUN
cet-13799	43	5	of	of	ADP
cet-13799	43	6	pat	pat	NOUN
cet-13799	43	7	tools	tool	NOUN
cet-13799	43	8	can	can	AUX
cet-13799	43	9	be	be	AUX
cet-13799	43	10	an	an	DET
cet-13799	43	11	excellent	excellent	ADJ
cet-13799	43	12	method	method	NOUN
cet-13799	43	13	towards	towards	ADP
cet-13799	43	14	including	include	VERB
cet-13799	43	15	considerations	consideration	NOUN
cet-13799	43	16	about	about	ADP
cet-13799	43	17	the	the	DET
cet-13799	43	18	cqas	cqas	NOUN
cet-13799	43	19	of	of	ADP
cet-13799	43	20	a	a	DET
cet-13799	43	21	product	product	NOUN
cet-13799	43	22	during	during	ADP
cet-13799	43	23	the	the	DET
cet-13799	43	24	design	design	NOUN
cet-13799	43	25	of	of	ADP
cet-13799	43	26	the	the	DET
cet-13799	43	27	product	product	NOUN
cet-13799	43	28	itself	itself	PRON
cet-13799	43	29	.	.	PUNCT
cet-13799	44	1	implementing	implement	VERB
cet-13799	44	2	such	such	ADJ
cet-13799	44	3	technologies	technology	NOUN
cet-13799	44	4	(	(	PUNCT
cet-13799	44	5	figure	figure	NOUN
cet-13799	44	6	1	1	NUM
cet-13799	44	7	)	)	PUNCT
cet-13799	44	8	requires	require	VERB
cet-13799	44	9	not	not	PART
cet-13799	44	10	only	only	ADV
cet-13799	44	11	a	a	DET
cet-13799	44	12	deeper	deep	ADJ
cet-13799	44	13	understanding	understanding	NOUN
cet-13799	44	14	of	of	ADP
cet-13799	44	15	the	the	DET
cet-13799	44	16	process	process	NOUN
cet-13799	44	17	and	and	CCONJ
cet-13799	44	18	the	the	DET
cet-13799	44	19	cpps	cpps	NOUN
cet-13799	44	20	that	that	PRON
cet-13799	44	21	influence	influence	VERB
cet-13799	44	22	the	the	DET
cet-13799	44	23	product	product	NOUN
cet-13799	44	24	’s	’s	PART
cet-13799	44	25	cqas	cqas	NOUN
cet-13799	44	26	but	but	CCONJ
cet-13799	44	27	also	also	ADV
cet-13799	44	28	expedites	expedite	VERB
cet-13799	44	29	further	further	ADJ
cet-13799	44	30	process	process	NOUN
cet-13799	44	31	understanding	understanding	NOUN
cet-13799	44	32	and	and	CCONJ
cet-13799	44	33	the	the	DET
cet-13799	44	34	necessary	necessary	ADJ
cet-13799	44	35	cmas	cma	NOUN
cet-13799	44	36	(	(	PUNCT
cet-13799	44	37	sacher	sacher	NOUN
cet-13799	44	38	et	et	PROPN
cet-13799	44	39	al	al	PROPN
cet-13799	44	40	.	.	PROPN
cet-13799	44	41	,	,	PUNCT
cet-13799	44	42	2022	2022	NUM
cet-13799	44	43	)	)	PUNCT
cet-13799	44	44	.	.	PUNCT
cet-13799	45	1	pat	pat	NOUN
cet-13799	45	2	tools	tool	NOUN
cet-13799	45	3	and	and	CCONJ
cet-13799	45	4	solutions	solution	NOUN
cet-13799	45	5	are	be	AUX
cet-13799	45	6	not	not	PART
cet-13799	45	7	novel	novel	ADJ
cet-13799	45	8	technologies	technology	NOUN
cet-13799	45	9	,	,	PUNCT
cet-13799	45	10	and	and	CCONJ
cet-13799	45	11	the	the	DET
cet-13799	45	12	integration	integration	NOUN
cet-13799	45	13	of	of	ADP
cet-13799	45	14	on	on	ADP
cet-13799	45	15	-	-	PUNCT
cet-13799	45	16	line	line	NOUN
cet-13799	45	17	and	and	CCONJ
cet-13799	45	18	in	in	ADP
cet-13799	45	19	-	-	PUNCT
cet-13799	45	20	line	line	NOUN
cet-13799	45	21	pat	pat	NOUN
cet-13799	45	22	tools	tool	NOUN
cet-13799	45	23	into	into	ADP
cet-13799	45	24	bioprocesses	bioprocesse	NOUN
cet-13799	45	25	has	have	AUX
cet-13799	45	26	steadily	steadily	ADV
cet-13799	45	27	increased	increase	VERB
cet-13799	45	28	over	over	ADP
cet-13799	45	29	the	the	DET
cet-13799	45	30	last	last	ADJ
cet-13799	45	31	couple	couple	NOUN
cet-13799	45	32	of	of	ADP
cet-13799	45	33	decades	decade	NOUN
cet-13799	45	34	in	in	ADP
cet-13799	45	35	many	many	ADJ
cet-13799	45	36	different	different	ADJ
cet-13799	45	37	ways	way	NOUN
cet-13799	45	38	despite	despite	SCONJ
cet-13799	45	39	the	the	DET
cet-13799	45	40	fact	fact	NOUN
cet-13799	45	41	that	that	SCONJ
cet-13799	45	42	such	such	ADJ
cet-13799	45	43	technologies	technology	NOUN
cet-13799	45	44	are	be	AUX
cet-13799	45	45	invasive	invasive	ADJ
cet-13799	45	46	and	and	CCONJ
cet-13799	45	47	need	need	VERB
cet-13799	45	48	to	to	PART
cet-13799	45	49	be	be	AUX
cet-13799	45	50	taken	take	VERB
cet-13799	45	51	into	into	ADP
cet-13799	45	52	account	account	NOUN
cet-13799	45	53	in	in	ADP
cet-13799	45	54	the	the	DET
cet-13799	45	55	process	process	NOUN
cet-13799	45	56	space	space	NOUN
cet-13799	45	57	and	and	CCONJ
cet-13799	45	58	design	design	NOUN
cet-13799	45	59	(	(	PUNCT
cet-13799	45	60	gerzon	gerzon	PROPN
cet-13799	45	61	et	et	PROPN
cet-13799	45	62	al	al	PROPN
cet-13799	45	63	.	.	PROPN
cet-13799	45	64	,	,	PUNCT
cet-13799	45	65	2022	2022	NUM
cet-13799	45	66	)	)	PUNCT
cet-13799	45	67	,	,	PUNCT
cet-13799	45	68	as	as	SCONJ
cet-13799	45	69	seen	see	VERB
cet-13799	45	70	in	in	ADP
cet-13799	45	71	figure	figure	NOUN
cet-13799	45	72	1	1	NUM
cet-13799	45	73	.	.	PUNCT
cet-13799	45	74	product	product	NOUN
cet-13799	45	75	integrity	integrity	NOUN
cet-13799	45	76	must	must	AUX
cet-13799	45	77	also	also	ADV
cet-13799	45	78	be	be	AUX
cet-13799	45	79	considered	consider	VERB
cet-13799	45	80	with	with	ADP
cet-13799	45	81	in	in	ADP
cet-13799	45	82	-	-	PUNCT
cet-13799	45	83	line	line	NOUN
cet-13799	45	84	measurement	measurement	NOUN
cet-13799	45	85	techniques	technique	NOUN
cet-13799	45	86	since	since	SCONJ
cet-13799	45	87	the	the	DET
cet-13799	45	88	quality	quality	NOUN
cet-13799	45	89	requirements	requirement	NOUN
cet-13799	45	90	in	in	ADP
cet-13799	45	91	the	the	DET
cet-13799	45	92	pharmaceutical	pharmaceutical	NOUN
cet-13799	45	93	industry	industry	NOUN
cet-13799	45	94	are	be	AUX
cet-13799	45	95	very	very	ADV
cet-13799	45	96	high	high	ADJ
cet-13799	45	97	.	.	PUNCT
cet-13799	46	1	only	only	ADV
cet-13799	46	2	within	within	ADP
cet-13799	46	3	the	the	DET
cet-13799	46	4	last	last	ADJ
cet-13799	46	5	few	few	ADJ
cet-13799	46	6	years	year	NOUN
cet-13799	46	7	has	have	VERB
cet-13799	46	8	the	the	DET
cet-13799	46	9	technology	technology	NOUN
cet-13799	46	10	really	really	ADV
cet-13799	46	11	been	be	AUX
cet-13799	46	12	used	use	VERB
cet-13799	46	13	for	for	ADP
cet-13799	46	14	real	real	ADJ
cet-13799	46	15	-	-	PUNCT
cet-13799	46	16	time	time	NOUN
cet-13799	46	17	monitoring	monitoring	NOUN
cet-13799	46	18	and	and	CCONJ
cet-13799	46	19	control	control	NOUN
cet-13799	46	20	within	within	ADP
cet-13799	46	21	the	the	DET
cet-13799	46	22	(	(	PUNCT
cet-13799	46	23	bio)pharmaceutical	bio)pharmaceutical	ADJ
cet-13799	46	24	industry	industry	NOUN
cet-13799	46	25	.	.	PUNCT
cet-13799	47	1	due	due	ADP
cet-13799	47	2	to	to	ADP
cet-13799	47	3	the	the	DET
cet-13799	47	4	emphasis	emphasis	NOUN
cet-13799	47	5	on	on	ADP
cet-13799	47	6	i4.0	i4.0	PROPN
cet-13799	47	7	concepts	concept	NOUN
cet-13799	47	8	in	in	ADP
cet-13799	47	9	this	this	DET
cet-13799	47	10	work	work	NOUN
cet-13799	47	11	,	,	PUNCT
cet-13799	47	12	it	it	PRON
cet-13799	47	13	was	be	AUX
cet-13799	47	14	interesting	interesting	ADJ
cet-13799	47	15	to	to	PART
cet-13799	47	16	note	note	VERB
cet-13799	47	17	the	the	DET
cet-13799	47	18	integration	integration	NOUN
cet-13799	47	19	of	of	ADP
cet-13799	47	20	pat	pat	NOUN
cet-13799	47	21	-	-	PUNCT
cet-13799	47	22	based	base	VERB
cet-13799	47	23	monitoring	monitoring	NOUN
cet-13799	47	24	and	and	CCONJ
cet-13799	47	25	control	control	NOUN
cet-13799	47	26	with	with	ADP
cet-13799	47	27	a	a	DET
cet-13799	47	28	cyber	cyber	ADJ
cet-13799	47	29	-	-	PUNCT
cet-13799	47	30	physical	physical	ADJ
cet-13799	47	31	network	network	NOUN
cet-13799	47	32	that	that	PRON
cet-13799	47	33	is	be	AUX
cet-13799	47	34	able	able	ADJ
cet-13799	47	35	to	to	PART
cet-13799	47	36	provide	provide	VERB
cet-13799	47	37	real	real	ADJ
cet-13799	47	38	-	-	PUNCT
cet-13799	47	39	time	time	NOUN
cet-13799	47	40	optimization	optimization	NOUN
cet-13799	47	41	and	and	CCONJ
cet-13799	47	42	predictions	prediction	NOUN
cet-13799	47	43	of	of	ADP
cet-13799	47	44	the	the	DET
cet-13799	47	45	process	process	NOUN
cet-13799	47	46	.	.	PUNCT
cet-13799	48	1	this	this	PRON
cet-13799	48	2	is	be	AUX
cet-13799	48	3	a	a	DET
cet-13799	48	4	relatively	relatively	ADV
cet-13799	48	5	new	new	ADJ
cet-13799	48	6	concept	concept	NOUN
cet-13799	48	7	,	,	PUNCT
cet-13799	48	8	as	as	SCONJ
cet-13799	48	9	few	few	ADJ
cet-13799	48	10	papers	paper	NOUN
cet-13799	48	11	dealt	deal	VERB
cet-13799	48	12	with	with	ADP
cet-13799	48	13	the	the	DET
cet-13799	48	14	review	review	NOUN
cet-13799	48	15	and	and	CCONJ
cet-13799	48	16	concept	concept	NOUN
cet-13799	48	17	of	of	ADP
cet-13799	48	18	such	such	DET
cet-13799	48	19	a	a	DET
cet-13799	48	20	collaboration	collaboration	NOUN
cet-13799	48	21	(	(	PUNCT
cet-13799	48	22	arden	arden	PROPN
cet-13799	48	23	et	et	PROPN
cet-13799	48	24	al	al	PROPN
cet-13799	48	25	.	.	PROPN
cet-13799	48	26	,	,	PUNCT
cet-13799	48	27	2021	2021	NUM
cet-13799	48	28	)	)	PUNCT
cet-13799	48	29	.	.	PUNCT
cet-13799	49	1	long	long	ADJ
cet-13799	49	2	-	-	PUNCT
cet-13799	49	3	term	term	NOUN
cet-13799	49	4	data	datum	NOUN
cet-13799	49	5	storage	storage	NOUN
cet-13799	49	6	from	from	ADP
cet-13799	49	7	pat	pat	NOUN
cet-13799	49	8	tools	tool	NOUN
cet-13799	49	9	(	(	PUNCT
cet-13799	49	10	possible	possible	ADJ
cet-13799	49	11	through	through	ADP
cet-13799	49	12	cloud	cloud	NOUN
cet-13799	49	13	services	service	NOUN
cet-13799	49	14	and	and	CCONJ
cet-13799	49	15	a	a	DET
cet-13799	49	16	working	work	VERB
cet-13799	49	17	network	network	NOUN
cet-13799	49	18	of	of	ADP
cet-13799	49	19	the	the	DET
cet-13799	49	20	equipment	equipment	NOUN
cet-13799	49	21	and	and	CCONJ
cet-13799	49	22	machines	machine	NOUN
cet-13799	49	23	)	)	PUNCT
cet-13799	49	24	facilitates	facilitate	VERB
cet-13799	49	25	the	the	DET
cet-13799	49	26	set	set	NOUN
cet-13799	49	27	-	-	PUNCT
cet-13799	49	28	up	up	NOUN
cet-13799	49	29	of	of	ADP
cet-13799	49	30	dts	dt	NOUN
cet-13799	49	31	and	and	CCONJ
cet-13799	49	32	adaptive	adaptive	ADJ
cet-13799	49	33	control	control	NOUN
cet-13799	49	34	and	and	CCONJ
cet-13799	49	35	362	362	NUM
cet-13799	49	36	prediction	prediction	NOUN
cet-13799	49	37	,	,	PUNCT
cet-13799	49	38	among	among	ADP
cet-13799	49	39	other	other	ADJ
cet-13799	49	40	things	thing	NOUN
cet-13799	49	41	.	.	PUNCT
cet-13799	50	1	if	if	SCONJ
cet-13799	50	2	applied	apply	VERB
cet-13799	50	3	and	and	CCONJ
cet-13799	50	4	used	use	VERB
cet-13799	50	5	correctly	correctly	ADV
cet-13799	50	6	,	,	PUNCT
cet-13799	50	7	such	such	DET
cet-13799	50	8	a	a	DET
cet-13799	50	9	combination	combination	NOUN
cet-13799	50	10	can	can	AUX
cet-13799	50	11	lead	lead	VERB
cet-13799	50	12	to	to	ADP
cet-13799	50	13	a	a	DET
cet-13799	50	14	valid	valid	ADJ
cet-13799	50	15	smart	smart	ADJ
cet-13799	50	16	pharmaceutical	pharmaceutical	NOUN
cet-13799	50	17	process	process	NOUN
cet-13799	50	18	(	(	PUNCT
cet-13799	50	19	barenji	barenji	NOUN
cet-13799	50	20	et	et	PROPN
cet-13799	50	21	al	al	PROPN
cet-13799	50	22	.	.	PROPN
cet-13799	50	23	,	,	PUNCT
cet-13799	50	24	2019	2019	NUM
cet-13799	50	25	)	)	PUNCT
cet-13799	50	26	.	.	PUNCT
cet-13799	51	1	figure	figure	VERB
cet-13799	51	2	1	1	NUM
cet-13799	51	3	:	:	PUNCT
cet-13799	51	4	major	major	ADJ
cet-13799	51	5	goals	goal	NOUN
cet-13799	51	6	of	of	ADP
cet-13799	51	7	pat	pat	NOUN
cet-13799	51	8	utilization	utilization	NOUN
cet-13799	51	9	in	in	ADP
cet-13799	51	10	terms	term	NOUN
cet-13799	51	11	of	of	ADP
cet-13799	51	12	sustainability	sustainability	NOUN
cet-13799	51	13	(	(	PUNCT
cet-13799	51	14	top	top	NOUN
cet-13799	51	15	left	left	ADJ
cet-13799	51	16	)	)	PUNCT
cet-13799	51	17	,	,	PUNCT
cet-13799	51	18	adapted	adapt	VERB
cet-13799	51	19	from	from	ADP
cet-13799	51	20	gerzon	gerzon	PROPN
cet-13799	51	21	et	et	PROPN
cet-13799	51	22	al	al	PROPN
cet-13799	51	23	.	.	PROPN
cet-13799	52	1	(	(	PUNCT
cet-13799	52	2	2022	2022	NUM
cet-13799	52	3	)	)	PUNCT
cet-13799	52	4	;	;	PUNCT
cet-13799	52	5	three	three	NUM
cet-13799	52	6	broad	broad	ADJ
cet-13799	52	7	steps	step	NOUN
cet-13799	52	8	towards	towards	ADP
cet-13799	52	9	pat	pat	NOUN
cet-13799	52	10	implementation	implementation	NOUN
cet-13799	52	11	(	(	PUNCT
cet-13799	52	12	bottom	bottom	NOUN
cet-13799	52	13	left	left	ADJ
cet-13799	52	14	)	)	PUNCT
cet-13799	52	15	,	,	PUNCT
cet-13799	52	16	adapted	adapt	VERB
cet-13799	52	17	from	from	ADP
cet-13799	52	18	sacher	sacher	PROPN
cet-13799	52	19	et	et	PROPN
cet-13799	52	20	al	al	PROPN
cet-13799	52	21	.	.	PROPN
cet-13799	53	1	(	(	PUNCT
cet-13799	53	2	2022	2022	NUM
cet-13799	53	3	)	)	PUNCT
cet-13799	53	4	;	;	PUNCT
cet-13799	53	5	few	few	ADJ
cet-13799	53	6	of	of	ADP
cet-13799	53	7	many	many	ADJ
cet-13799	53	8	different	different	ADJ
cet-13799	53	9	methods	method	NOUN
cet-13799	53	10	of	of	ADP
cet-13799	53	11	pat	pat	NOUN
cet-13799	53	12	employment	employment	NOUN
cet-13799	53	13	in	in	ADP
cet-13799	53	14	the	the	DET
cet-13799	53	15	pharmaceutical	pharmaceutical	NOUN
cet-13799	53	16	industry	industry	NOUN
cet-13799	53	17	;	;	PUNCT
cet-13799	53	18	vcc	vcc	NOUN
cet-13799	53	19	:	:	PUNCT
cet-13799	53	20	viable	viable	ADJ
cet-13799	53	21	cell	cell	NOUN
cet-13799	53	22	count	count	NOUN
cet-13799	53	23	(	(	PUNCT
cet-13799	53	24	right	right	NOUN
cet-13799	53	25	)	)	PUNCT
cet-13799	53	26	;	;	PUNCT
cet-13799	53	27	adapted	adapt	VERB
cet-13799	53	28	from	from	ADP
cet-13799	53	29	kempf	kempf	PROPN
cet-13799	53	30	(	(	PUNCT
cet-13799	53	31	2018	2018	NUM
cet-13799	53	32	)	)	PUNCT
cet-13799	53	33	,	,	PUNCT
cet-13799	53	34	barenji	barenji	NOUN
cet-13799	53	35	et	et	PROPN
cet-13799	53	36	al	al	PROPN
cet-13799	53	37	.	.	PROPN
cet-13799	54	1	(	(	PUNCT
cet-13799	54	2	2019	2019	NUM
cet-13799	54	3	)	)	PUNCT
cet-13799	54	4	,	,	PUNCT
cet-13799	54	5	fung	fung	PROPN
cet-13799	54	6	shek	shek	PROPN
cet-13799	54	7	and	and	CCONJ
cet-13799	54	8	betenbaugh	betenbaugh	ADJ
cet-13799	54	9	(	(	PUNCT
cet-13799	54	10	2021	2021	NUM
cet-13799	54	11	)	)	PUNCT
cet-13799	54	12	and	and	CCONJ
cet-13799	54	13	gerzon	gerzon	PROPN
cet-13799	54	14	et	et	PROPN
cet-13799	54	15	al	al	PROPN
cet-13799	54	16	.	.	PROPN
cet-13799	55	1	(	(	PUNCT
cet-13799	55	2	2022	2022	NUM
cet-13799	55	3	)	)	PUNCT
cet-13799	55	4	lastly	lastly	ADV
cet-13799	55	5	,	,	PUNCT
cet-13799	55	6	it	it	PRON
cet-13799	55	7	is	be	AUX
cet-13799	55	8	crucial	crucial	ADJ
cet-13799	55	9	to	to	PART
cet-13799	55	10	examine	examine	VERB
cet-13799	55	11	the	the	DET
cet-13799	55	12	effect	effect	NOUN
cet-13799	55	13	of	of	ADP
cet-13799	55	14	pat	pat	NOUN
cet-13799	55	15	implementation	implementation	NOUN
cet-13799	55	16	on	on	ADP
cet-13799	55	17	the	the	DET
cet-13799	55	18	green	green	ADJ
cet-13799	55	19	metrics	metric	NOUN
cet-13799	55	20	and	and	CCONJ
cet-13799	55	21	sustainability	sustainability	NOUN
cet-13799	55	22	of	of	ADP
cet-13799	55	23	a	a	DET
cet-13799	55	24	process	process	NOUN
cet-13799	55	25	.	.	PUNCT
cet-13799	56	1	as	as	SCONJ
cet-13799	56	2	the	the	DET
cet-13799	56	3	application	application	NOUN
cet-13799	56	4	of	of	ADP
cet-13799	56	5	pat	pat	PROPN
cet-13799	56	6	requires	require	VERB
cet-13799	56	7	a	a	DET
cet-13799	56	8	comprehensive	comprehensive	ADJ
cet-13799	56	9	process	process	NOUN
cet-13799	56	10	understanding	understanding	NOUN
cet-13799	56	11	and	and	CCONJ
cet-13799	56	12	,	,	PUNCT
cet-13799	56	13	ideally	ideally	ADV
cet-13799	56	14	,	,	PUNCT
cet-13799	56	15	a	a	DET
cet-13799	56	16	real	real	ADJ
cet-13799	56	17	-	-	PUNCT
cet-13799	56	18	time	time	NOUN
cet-13799	56	19	and	and	CCONJ
cet-13799	56	20	in-/on	in-/on	NOUN
cet-13799	56	21	-	-	NOUN
cet-13799	56	22	line	line	NOUN
cet-13799	56	23	monitoring	monitoring	NOUN
cet-13799	56	24	and	and	CCONJ
cet-13799	56	25	control	control	NOUN
cet-13799	56	26	framework	framework	NOUN
cet-13799	56	27	to	to	PART
cet-13799	56	28	function	function	VERB
cet-13799	56	29	properly	properly	ADV
cet-13799	56	30	,	,	PUNCT
cet-13799	56	31	this	this	PRON
cet-13799	56	32	can	can	AUX
cet-13799	56	33	lead	lead	VERB
cet-13799	56	34	to	to	ADP
cet-13799	56	35	a	a	DET
cet-13799	56	36	minimization	minimization	NOUN
cet-13799	56	37	of	of	ADP
cet-13799	56	38	experimentation	experimentation	NOUN
cet-13799	56	39	and	and	CCONJ
cet-13799	56	40	trials	trial	NOUN
cet-13799	56	41	towards	towards	ADP
cet-13799	56	42	the	the	DET
cet-13799	56	43	desired	desire	VERB
cet-13799	56	44	product	product	NOUN
cet-13799	56	45	quality	quality	NOUN
cet-13799	56	46	and	and	CCONJ
cet-13799	56	47	output	output	NOUN
cet-13799	56	48	.	.	PUNCT
cet-13799	57	1	hence	hence	ADV
cet-13799	57	2	,	,	PUNCT
cet-13799	57	3	the	the	DET
cet-13799	57	4	aforementioned	aforementioned	ADJ
cet-13799	57	5	prior	prior	ADJ
cet-13799	57	6	knowledge	knowledge	NOUN
cet-13799	57	7	of	of	ADP
cet-13799	57	8	process	process	NOUN
cet-13799	57	9	and	and	CCONJ
cet-13799	57	10	product	product	NOUN
cet-13799	57	11	design	design	NOUN
cet-13799	57	12	can	can	AUX
cet-13799	57	13	have	have	VERB
cet-13799	57	14	a	a	DET
cet-13799	57	15	waste	waste	NOUN
cet-13799	57	16	and	and	CCONJ
cet-13799	57	17	resource	resource	NOUN
cet-13799	57	18	minimization	minimization	NOUN
cet-13799	57	19	effect	effect	NOUN
cet-13799	57	20	,	,	PUNCT
cet-13799	57	21	thus	thus	ADV
cet-13799	57	22	improving	improve	VERB
cet-13799	57	23	green	green	ADJ
cet-13799	57	24	metrics	metric	NOUN
cet-13799	57	25	.	.	PUNCT
cet-13799	58	1	however	however	ADV
cet-13799	58	2	,	,	PUNCT
cet-13799	58	3	it	it	PRON
cet-13799	58	4	must	must	AUX
cet-13799	58	5	be	be	AUX
cet-13799	58	6	mentioned	mention	VERB
cet-13799	58	7	that	that	SCONJ
cet-13799	58	8	the	the	DET
cet-13799	58	9	effect	effect	NOUN
cet-13799	58	10	of	of	ADP
cet-13799	58	11	power	power	NOUN
cet-13799	58	12	consumption	consumption	NOUN
cet-13799	58	13	due	due	ADP
cet-13799	58	14	to	to	ADP
cet-13799	58	15	such	such	ADJ
cet-13799	58	16	cloud	cloud	NOUN
cet-13799	58	17	technologies	technology	NOUN
cet-13799	58	18	must	must	AUX
cet-13799	58	19	also	also	ADV
cet-13799	58	20	be	be	AUX
cet-13799	58	21	considered	consider	VERB
cet-13799	58	22	(	(	PUNCT
cet-13799	58	23	kaur	kaur	PROPN
cet-13799	58	24	et	et	PROPN
cet-13799	58	25	al	al	PROPN
cet-13799	58	26	.	.	PROPN
cet-13799	58	27	,	,	PUNCT
cet-13799	58	28	2018	2018	NUM
cet-13799	58	29	)	)	PUNCT
cet-13799	58	30	.	.	PUNCT
cet-13799	59	1	4.2	4.2	NUM
cet-13799	59	2	soft	soft	ADJ
cet-13799	59	3	sensors	sensor	NOUN
cet-13799	59	4	monitoring	monitor	VERB
cet-13799	59	5	and	and	CCONJ
cet-13799	59	6	observing	observe	VERB
cet-13799	59	7	critical	critical	ADJ
cet-13799	59	8	parameters	parameter	NOUN
cet-13799	59	9	is	be	AUX
cet-13799	59	10	essential	essential	ADJ
cet-13799	59	11	for	for	ADP
cet-13799	59	12	ensuring	ensure	VERB
cet-13799	59	13	product	product	NOUN
cet-13799	59	14	quality	quality	NOUN
cet-13799	59	15	and	and	CCONJ
cet-13799	59	16	maintaining	maintain	VERB
cet-13799	59	17	the	the	DET
cet-13799	59	18	process	process	NOUN
cet-13799	59	19	in	in	ADP
cet-13799	59	20	a	a	DET
cet-13799	59	21	desired	desire	VERB
cet-13799	59	22	and	and	CCONJ
cet-13799	59	23	robust	robust	ADJ
cet-13799	59	24	state	state	NOUN
cet-13799	59	25	.	.	PUNCT
cet-13799	60	1	process	process	NOUN
cet-13799	60	2	monitoring	monitoring	NOUN
cet-13799	60	3	does	do	AUX
cet-13799	60	4	not	not	PART
cet-13799	60	5	only	only	ADV
cet-13799	60	6	mean	mean	VERB
cet-13799	60	7	measuring	measure	VERB
cet-13799	60	8	certain	certain	ADJ
cet-13799	60	9	cpps	cpps	NOUN
cet-13799	60	10	and	and	CCONJ
cet-13799	60	11	cmas	cma	NOUN
cet-13799	60	12	.	.	PUNCT
cet-13799	61	1	process	process	NOUN
cet-13799	61	2	monitoring	monitoring	NOUN
cet-13799	61	3	refers	refer	VERB
cet-13799	61	4	to	to	ADP
cet-13799	61	5	measuring	measure	VERB
cet-13799	61	6	,	,	PUNCT
cet-13799	61	7	monitoring	monitoring	NOUN
cet-13799	61	8	,	,	PUNCT
cet-13799	61	9	modelling	modelling	NOUN
cet-13799	61	10	and	and	CCONJ
cet-13799	61	11	control	control	NOUN
cet-13799	61	12	(	(	PUNCT
cet-13799	61	13	m3c	m3c	NOUN
cet-13799	61	14	)	)	PUNCT
cet-13799	61	15	(	(	PUNCT
cet-13799	61	16	luttmann	luttmann	PROPN
cet-13799	61	17	et	et	PROPN
cet-13799	61	18	al	al	PROPN
cet-13799	61	19	.	.	PROPN
cet-13799	61	20	,	,	PUNCT
cet-13799	61	21	2012	2012	NUM
cet-13799	61	22	)	)	PUNCT
cet-13799	61	23	.	.	PUNCT
cet-13799	62	1	selected	select	VERB
cet-13799	62	2	process	process	NOUN
cet-13799	62	3	variables	variable	NOUN
cet-13799	62	4	are	be	AUX
cet-13799	62	5	tracked	track	VERB
cet-13799	62	6	over	over	ADP
cet-13799	62	7	time	time	NOUN
cet-13799	62	8	(	(	PUNCT
cet-13799	62	9	measuring	measure	VERB
cet-13799	62	10	)	)	PUNCT
cet-13799	62	11	,	,	PUNCT
cet-13799	62	12	deflections	deflection	NOUN
cet-13799	62	13	from	from	ADP
cet-13799	62	14	setpoints	setpoint	NOUN
cet-13799	62	15	are	be	AUX
cet-13799	62	16	detected	detect	VERB
cet-13799	62	17	(	(	PUNCT
cet-13799	62	18	monitoring	monitoring	NOUN
cet-13799	62	19	)	)	PUNCT
cet-13799	62	20	and	and	CCONJ
cet-13799	62	21	explained	explain	VERB
cet-13799	62	22	or	or	CCONJ
cet-13799	62	23	predicted	predict	VERB
cet-13799	62	24	(	(	PUNCT
cet-13799	62	25	modelling	modelling	NOUN
cet-13799	62	26	)	)	PUNCT
cet-13799	62	27	,	,	PUNCT
cet-13799	62	28	and	and	CCONJ
cet-13799	62	29	possible	possible	ADJ
cet-13799	62	30	actions	action	NOUN
cet-13799	62	31	are	be	AUX
cet-13799	62	32	evaluated	evaluate	VERB
cet-13799	62	33	(	(	PUNCT
cet-13799	62	34	control	control	NOUN
cet-13799	62	35	)	)	PUNCT
cet-13799	62	36	.	.	PUNCT
cet-13799	63	1	as	as	SCONJ
cet-13799	63	2	outlined	outline	VERB
cet-13799	63	3	in	in	ADP
cet-13799	63	4	the	the	DET
cet-13799	63	5	previous	previous	ADJ
cet-13799	63	6	section	section	NOUN
cet-13799	63	7	,	,	PUNCT
cet-13799	63	8	proper	proper	ADJ
cet-13799	63	9	pat	pat	NOUN
cet-13799	63	10	methods	method	NOUN
cet-13799	63	11	are	be	AUX
cet-13799	63	12	required	require	VERB
cet-13799	63	13	to	to	PART
cet-13799	63	14	measure	measure	VERB
cet-13799	63	15	cmas	cma	NOUN
cet-13799	63	16	and	and	CCONJ
cet-13799	63	17	cpps	cpp	NOUN
cet-13799	63	18	.	.	PUNCT
cet-13799	64	1	however	however	ADV
cet-13799	64	2	,	,	PUNCT
cet-13799	64	3	not	not	PART
cet-13799	64	4	all	all	DET
cet-13799	64	5	measurements	measurement	NOUN
cet-13799	64	6	are	be	AUX
cet-13799	64	7	directly	directly	ADV
cet-13799	64	8	accessible	accessible	ADJ
cet-13799	64	9	or	or	CCONJ
cet-13799	64	10	measurable	measurable	ADJ
cet-13799	64	11	at	at	ADP
cet-13799	64	12	a	a	DET
cet-13799	64	13	sufficient	sufficient	ADJ
cet-13799	64	14	frequency	frequency	NOUN
cet-13799	64	15	.	.	PUNCT
cet-13799	65	1	if	if	SCONJ
cet-13799	65	2	specific	specific	ADJ
cet-13799	65	3	off	off	ADP
cet-13799	65	4	-	-	PUNCT
cet-13799	65	5	line	line	NOUN
cet-13799	65	6	or	or	CCONJ
cet-13799	65	7	at	at	ADP
cet-13799	65	8	-	-	PUNCT
cet-13799	65	9	line	line	NOUN
cet-13799	65	10	measurements	measurement	NOUN
cet-13799	65	11	are	be	AUX
cet-13799	65	12	identified	identify	VERB
cet-13799	65	13	as	as	ADP
cet-13799	65	14	being	be	AUX
cet-13799	65	15	critical	critical	ADJ
cet-13799	65	16	,	,	PUNCT
cet-13799	65	17	the	the	DET
cet-13799	65	18	time	time	NOUN
cet-13799	65	19	delay	delay	NOUN
cet-13799	65	20	between	between	ADP
cet-13799	65	21	sampling	sample	VERB
cet-13799	65	22	and	and	CCONJ
cet-13799	65	23	the	the	DET
cet-13799	65	24	availability	availability	NOUN
cet-13799	65	25	of	of	ADP
cet-13799	65	26	results	result	NOUN
cet-13799	65	27	leads	lead	VERB
cet-13799	65	28	to	to	ADP
cet-13799	65	29	delayed	delay	VERB
cet-13799	65	30	quality	quality	NOUN
cet-13799	65	31	checks	check	NOUN
cet-13799	65	32	(	(	PUNCT
cet-13799	65	33	gerzon	gerzon	PROPN
cet-13799	65	34	et	et	PROPN
cet-13799	65	35	al	al	PROPN
cet-13799	65	36	.	.	PROPN
cet-13799	65	37	,	,	PUNCT
cet-13799	65	38	2022	2022	NUM
cet-13799	65	39	)	)	PUNCT
cet-13799	65	40	.	.	PUNCT
cet-13799	66	1	time	time	NOUN
cet-13799	66	2	delay	delay	NOUN
cet-13799	66	3	is	be	AUX
cet-13799	66	4	even	even	ADV
cet-13799	66	5	more	more	ADV
cet-13799	66	6	critical	critical	ADJ
cet-13799	66	7	in	in	ADP
cet-13799	66	8	continuous	continuous	ADJ
cet-13799	66	9	manufacturing	manufacturing	NOUN
cet-13799	66	10	since	since	SCONJ
cet-13799	66	11	missed	miss	VERB
cet-13799	66	12	quality	quality	NOUN
cet-13799	66	13	targets	target	NOUN
cet-13799	66	14	are	be	AUX
cet-13799	66	15	propagated	propagate	VERB
cet-13799	66	16	in	in	ADP
cet-13799	66	17	downstream	downstream	ADJ
cet-13799	66	18	units	unit	NOUN
cet-13799	66	19	.	.	PUNCT
cet-13799	67	1	furthermore	furthermore	ADV
cet-13799	67	2	,	,	PUNCT
cet-13799	67	3	in	in	ADP
cet-13799	67	4	-	-	PUNCT
cet-13799	67	5	line	line	NOUN
cet-13799	67	6	measurements	measurement	NOUN
cet-13799	67	7	with	with	ADP
cet-13799	67	8	hard	hard	ADJ
cet-13799	67	9	sensors	sensor	NOUN
cet-13799	67	10	are	be	AUX
cet-13799	67	11	a	a	DET
cet-13799	67	12	potential	potential	ADJ
cet-13799	67	13	risk	risk	NOUN
cet-13799	67	14	of	of	ADP
cet-13799	67	15	contamination	contamination	NOUN
cet-13799	67	16	due	due	ADP
cet-13799	67	17	to	to	ADP
cet-13799	67	18	their	their	PRON
cet-13799	67	19	invasive	invasive	ADJ
cet-13799	67	20	nature	nature	NOUN
cet-13799	67	21	(	(	PUNCT
cet-13799	67	22	luttmann	luttmann	PROPN
cet-13799	67	23	et	et	PROPN
cet-13799	67	24	al	al	PROPN
cet-13799	67	25	.	.	PROPN
cet-13799	67	26	,	,	PUNCT
cet-13799	67	27	2012	2012	NUM
cet-13799	67	28	)	)	PUNCT
cet-13799	67	29	.	.	PUNCT
cet-13799	68	1	a	a	DET
cet-13799	68	2	model	model	NOUN
cet-13799	68	3	-	-	PUNCT
cet-13799	68	4	based	base	VERB
cet-13799	68	5	tool	tool	NOUN
cet-13799	68	6	established	establish	VERB
cet-13799	68	7	particularly	particularly	ADV
cet-13799	68	8	in	in	ADP
cet-13799	68	9	bioprocess	bioprocess	NOUN
cet-13799	68	10	technology	technology	NOUN
cet-13799	68	11	is	be	AUX
cet-13799	68	12	soft	soft	ADJ
cet-13799	68	13	sensors	sensor	NOUN
cet-13799	68	14	(	(	PUNCT
cet-13799	68	15	software	software	NOUN
cet-13799	68	16	sensors	sensor	NOUN
cet-13799	68	17	)	)	PUNCT
cet-13799	68	18	.	.	PUNCT
cet-13799	69	1	soft	soft	ADJ
cet-13799	69	2	sensors	sensor	NOUN
cet-13799	69	3	combine	combine	VERB
cet-13799	69	4	a	a	DET
cet-13799	69	5	mathematical	mathematical	ADJ
cet-13799	69	6	model	model	NOUN
cet-13799	69	7	with	with	ADP
cet-13799	69	8	indirect	indirect	ADJ
cet-13799	69	9	or	or	CCONJ
cet-13799	69	10	secondary	secondary	ADJ
cet-13799	69	11	measurements	measurement	NOUN
cet-13799	69	12	(	(	PUNCT
cet-13799	69	13	kroll	kroll	PROPN
cet-13799	69	14	et	et	PROPN
cet-13799	69	15	al	al	PROPN
cet-13799	69	16	.	.	PROPN
cet-13799	69	17	,	,	PUNCT
cet-13799	69	18	2017	2017	NUM
cet-13799	69	19	)	)	PUNCT
cet-13799	69	20	.	.	PUNCT
cet-13799	70	1	in	in	ADP
cet-13799	70	2	the	the	DET
cet-13799	70	3	context	context	NOUN
cet-13799	70	4	of	of	ADP
cet-13799	70	5	control	control	NOUN
cet-13799	70	6	theory	theory	NOUN
cet-13799	70	7	,	,	PUNCT
cet-13799	70	8	a	a	DET
cet-13799	70	9	soft	soft	ADJ
cet-13799	70	10	sensor	sensor	NOUN
cet-13799	70	11	is	be	AUX
cet-13799	70	12	a	a	DET
cet-13799	70	13	state	state	NOUN
cet-13799	70	14	observer	observer	NOUN
cet-13799	70	15	predicting	predict	VERB
cet-13799	70	16	input	input	NOUN
cet-13799	70	17	-	-	PUNCT
cet-13799	70	18	output	output	NOUN
cet-13799	70	19	relations	relation	NOUN
cet-13799	70	20	in	in	ADP
cet-13799	70	21	a	a	DET
cet-13799	70	22	finite	finite	ADJ
cet-13799	70	23	time	time	NOUN
cet-13799	70	24	horizon	horizon	NOUN
cet-13799	70	25	(	(	PUNCT
cet-13799	70	26	golabgir	golabgir	PROPN
cet-13799	70	27	et	et	PROPN
cet-13799	70	28	al	al	PROPN
cet-13799	70	29	.	.	PROPN
cet-13799	70	30	,	,	PUNCT
cet-13799	70	31	2015	2015	NUM
cet-13799	70	32	)	)	PUNCT
cet-13799	70	33	.	.	PUNCT
cet-13799	71	1	inputs	input	NOUN
cet-13799	71	2	are	be	AUX
cet-13799	71	3	the	the	DET
cet-13799	71	4	online	online	ADV
cet-13799	71	5	measured	measure	VERB
cet-13799	71	6	,	,	PUNCT
cet-13799	71	7	non	non	ADJ
cet-13799	71	8	-	-	ADJ
cet-13799	71	9	invasive	invasive	ADJ
cet-13799	71	10	363	363	NUM
cet-13799	71	11	process	process	NOUN
cet-13799	71	12	variables	variable	NOUN
cet-13799	71	13	,	,	PUNCT
cet-13799	71	14	while	while	SCONJ
cet-13799	71	15	the	the	DET
cet-13799	71	16	outputs	output	NOUN
cet-13799	71	17	are	be	AUX
cet-13799	71	18	the	the	DET
cet-13799	71	19	predicted	predict	VERB
cet-13799	71	20	process	process	NOUN
cet-13799	71	21	states	state	NOUN
cet-13799	71	22	.	.	PUNCT
cet-13799	72	1	to	to	PART
cet-13799	72	2	ensure	ensure	VERB
cet-13799	72	3	reliability	reliability	NOUN
cet-13799	72	4	and	and	CCONJ
cet-13799	72	5	trust	trust	NOUN
cet-13799	72	6	in	in	ADP
cet-13799	72	7	the	the	DET
cet-13799	72	8	soft	soft	ADJ
cet-13799	72	9	sensor	sensor	NOUN
cet-13799	72	10	,	,	PUNCT
cet-13799	72	11	an	an	DET
cet-13799	72	12	analysis	analysis	NOUN
cet-13799	72	13	of	of	ADP
cet-13799	72	14	the	the	DET
cet-13799	72	15	significance	significance	NOUN
cet-13799	72	16	and	and	CCONJ
cet-13799	72	17	identifiability	identifiability	NOUN
cet-13799	72	18	of	of	ADP
cet-13799	72	19	the	the	DET
cet-13799	72	20	model	model	NOUN
cet-13799	72	21	parameters	parameter	NOUN
cet-13799	72	22	is	be	AUX
cet-13799	72	23	recommended	recommend	VERB
cet-13799	72	24	.	.	PUNCT
cet-13799	73	1	an	an	DET
cet-13799	73	2	observability	observability	NOUN
cet-13799	73	3	analysis	analysis	NOUN
cet-13799	73	4	aids	aid	NOUN
cet-13799	73	5	in	in	ADP
cet-13799	73	6	proving	prove	VERB
cet-13799	73	7	the	the	DET
cet-13799	73	8	appropriateness	appropriateness	NOUN
cet-13799	73	9	of	of	ADP
cet-13799	73	10	the	the	DET
cet-13799	73	11	model	model	NOUN
cet-13799	73	12	structure	structure	NOUN
cet-13799	73	13	with	with	ADP
cet-13799	73	14	respect	respect	NOUN
cet-13799	73	15	to	to	ADP
cet-13799	73	16	the	the	DET
cet-13799	73	17	information	information	NOUN
cet-13799	73	18	content	content	NOUN
cet-13799	73	19	of	of	ADP
cet-13799	73	20	measurements	measurement	NOUN
cet-13799	73	21	(	(	PUNCT
cet-13799	73	22	kroll	kroll	PROPN
cet-13799	73	23	et	et	PROPN
cet-13799	73	24	al	al	PROPN
cet-13799	73	25	.	.	PROPN
cet-13799	73	26	,	,	PUNCT
cet-13799	73	27	2017	2017	NUM
cet-13799	73	28	)	)	PUNCT
cet-13799	73	29	.	.	PUNCT
cet-13799	74	1	soft	soft	ADJ
cet-13799	74	2	sensors	sensor	NOUN
cet-13799	74	3	are	be	AUX
cet-13799	74	4	used	use	VERB
cet-13799	74	5	in	in	ADP
cet-13799	74	6	different	different	ADJ
cet-13799	74	7	scenarios	scenario	NOUN
cet-13799	74	8	.	.	PUNCT
cet-13799	75	1	müller	müller	PROPN
cet-13799	75	2	et	et	PROPN
cet-13799	75	3	al	al	PROPN
cet-13799	75	4	.	.	PROPN
cet-13799	76	1	(	(	PUNCT
cet-13799	76	2	2023	2023	NUM
cet-13799	76	3	)	)	PUNCT
cet-13799	76	4	demonstrated	demonstrate	VERB
cet-13799	76	5	the	the	DET
cet-13799	76	6	applicability	applicability	NOUN
cet-13799	76	7	of	of	ADP
cet-13799	76	8	a	a	DET
cet-13799	76	9	soft	soft	ADJ
cet-13799	76	10	sensor	sensor	NOUN
cet-13799	76	11	for	for	ADP
cet-13799	76	12	estimating	estimate	VERB
cet-13799	76	13	the	the	DET
cet-13799	76	14	maximum	maximum	ADJ
cet-13799	76	15	substrate	substrate	NOUN
cet-13799	76	16	uptake	uptake	ADJ
cet-13799	76	17	capacity	capacity	NOUN
cet-13799	76	18	and	and	CCONJ
cet-13799	76	19	the	the	DET
cet-13799	76	20	yield	yield	NOUN
cet-13799	76	21	coefficient	coefficient	NOUN
cet-13799	76	22	in	in	ADP
cet-13799	76	23	a	a	DET
cet-13799	76	24	fed	feed	VERB
cet-13799	76	25	-	-	PUNCT
cet-13799	76	26	batch	batch	NOUN
cet-13799	76	27	e.	e.	PROPN
cet-13799	76	28	coli	coli	NOUN
cet-13799	76	29	cultivation	cultivation	NOUN
cet-13799	76	30	.	.	PUNCT
cet-13799	77	1	a	a	DET
cet-13799	77	2	soft	soft	ADJ
cet-13799	77	3	sensor	sensor	NOUN
cet-13799	77	4	based	base	VERB
cet-13799	77	5	on	on	ADP
cet-13799	77	6	off	off	ADP
cet-13799	77	7	-	-	PUNCT
cet-13799	77	8	gas	gas	NOUN
cet-13799	77	9	measurements	measurement	NOUN
cet-13799	77	10	was	be	AUX
cet-13799	77	11	utilized	utilize	VERB
cet-13799	77	12	to	to	PART
cet-13799	77	13	prevent	prevent	VERB
cet-13799	77	14	overfeeding	overfeeding	NOUN
cet-13799	77	15	of	of	ADP
cet-13799	77	16	induced	induced	ADJ
cet-13799	77	17	cultures	culture	NOUN
cet-13799	77	18	due	due	ADJ
cet-13799	77	19	to	to	ADP
cet-13799	77	20	changes	change	NOUN
cet-13799	77	21	in	in	ADP
cet-13799	77	22	cell	cell	NOUN
cet-13799	77	23	hunger	hunger	NOUN
cet-13799	77	24	.	.	PUNCT
cet-13799	78	1	sagmeister	sagmeister	ADP
cet-13799	78	2	et	et	PROPN
cet-13799	78	3	al	al	PROPN
cet-13799	78	4	.	.	PROPN
cet-13799	79	1	(	(	PUNCT
cet-13799	79	2	2013	2013	NUM
cet-13799	79	3	)	)	PUNCT
cet-13799	79	4	applied	apply	VERB
cet-13799	79	5	a	a	DET
cet-13799	79	6	soft	soft	ADJ
cet-13799	79	7	sensor	sensor	NOUN
cet-13799	79	8	for	for	ADP
cet-13799	79	9	static	static	ADJ
cet-13799	79	10	and	and	CCONJ
cet-13799	79	11	dynamic	dynamic	ADJ
cet-13799	79	12	control	control	NOUN
cet-13799	79	13	of	of	ADP
cet-13799	79	14	specific	specific	ADJ
cet-13799	79	15	substrate	substrate	NOUN
cet-13799	79	16	update	update	NOUN
cet-13799	79	17	rates	rate	NOUN
cet-13799	79	18	of	of	ADP
cet-13799	79	19	induced	induced	ADJ
cet-13799	79	20	p.	p.	PROPN
cet-13799	79	21	pastoris	pastoris	PROPN
cet-13799	79	22	and	and	CCONJ
cet-13799	79	23	e.	e.	PROPN
cet-13799	79	24	coli	coli	NOUN
cet-13799	79	25	expression	expression	NOUN
cet-13799	79	26	systems	system	NOUN
cet-13799	79	27	.	.	PUNCT
cet-13799	80	1	soft	soft	ADJ
cet-13799	80	2	sensors	sensor	NOUN
cet-13799	80	3	are	be	AUX
cet-13799	80	4	considered	consider	VERB
cet-13799	80	5	to	to	PART
cet-13799	80	6	be	be	AUX
cet-13799	80	7	highly	highly	ADV
cet-13799	80	8	valuable	valuable	ADJ
cet-13799	80	9	tools	tool	NOUN
cet-13799	80	10	for	for	ADP
cet-13799	80	11	continuous	continuous	ADJ
cet-13799	80	12	and	and	CCONJ
cet-13799	80	13	greener	green	ADJ
cet-13799	80	14	bioprocesses	bioprocesse	NOUN
cet-13799	80	15	.	.	PUNCT
cet-13799	81	1	integrating	integrate	VERB
cet-13799	81	2	machine	machine	NOUN
cet-13799	81	3	learning	learning	NOUN
cet-13799	81	4	models	model	NOUN
cet-13799	81	5	(	(	PUNCT
cet-13799	81	6	artificial	artificial	ADJ
cet-13799	81	7	neural	neural	ADJ
cet-13799	81	8	networks	network	NOUN
cet-13799	81	9	,	,	PUNCT
cet-13799	81	10	partial	partial	ADJ
cet-13799	81	11	least	least	ADJ
cet-13799	81	12	squares	square	NOUN
cet-13799	81	13	)	)	PUNCT
cet-13799	81	14	into	into	ADP
cet-13799	81	15	soft	soft	ADJ
cet-13799	81	16	sensor	sensor	NOUN
cet-13799	81	17	models	model	NOUN
cet-13799	81	18	seems	seem	VERB
cet-13799	81	19	to	to	PART
cet-13799	81	20	be	be	AUX
cet-13799	81	21	of	of	ADP
cet-13799	81	22	very	very	ADV
cet-13799	81	23	high	high	ADJ
cet-13799	81	24	interest	interest	NOUN
cet-13799	81	25	.	.	PUNCT
cet-13799	82	1	data	data	NOUN
cet-13799	82	2	-	-	PUNCT
cet-13799	82	3	driven	drive	VERB
cet-13799	82	4	models	model	NOUN
cet-13799	82	5	would	would	AUX
cet-13799	82	6	ease	ease	VERB
cet-13799	82	7	handling	handle	VERB
cet-13799	82	8	large	large	ADJ
cet-13799	82	9	data	datum	NOUN
cet-13799	82	10	sets	set	NOUN
cet-13799	82	11	while	while	SCONJ
cet-13799	82	12	difficult	difficult	ADJ
cet-13799	82	13	-	-	PUNCT
cet-13799	82	14	to	to	ADP
cet-13799	82	15	-	-	PUNCT
cet-13799	82	16	quantify	quantify	ADJ
cet-13799	82	17	parameters	parameter	NOUN
cet-13799	82	18	(	(	PUNCT
cet-13799	82	19	e.g.	e.g.	ADV
cet-13799	82	20	,	,	PUNCT
cet-13799	82	21	ph	ph	VERB
cet-13799	82	22	)	)	PUNCT
cet-13799	82	23	could	could	AUX
cet-13799	82	24	be	be	AUX
cet-13799	82	25	incorporated	incorporate	VERB
cet-13799	82	26	.	.	PUNCT
cet-13799	83	1	apart	apart	ADV
cet-13799	83	2	from	from	ADP
cet-13799	83	3	enabling	enable	VERB
cet-13799	83	4	rapid	rapid	ADJ
cet-13799	83	5	quality	quality	NOUN
cet-13799	83	6	checks	check	NOUN
cet-13799	83	7	,	,	PUNCT
cet-13799	83	8	soft	soft	ADJ
cet-13799	83	9	sensors	sensor	NOUN
cet-13799	83	10	are	be	AUX
cet-13799	83	11	cheaper	cheap	ADJ
cet-13799	83	12	in	in	ADP
cet-13799	83	13	comparison	comparison	NOUN
cet-13799	83	14	to	to	ADP
cet-13799	83	15	hard	hard	ADJ
cet-13799	83	16	sensors	sensor	NOUN
cet-13799	83	17	.	.	PUNCT
cet-13799	84	1	they	they	PRON
cet-13799	84	2	have	have	AUX
cet-13799	84	3	proven	prove	VERB
cet-13799	84	4	to	to	PART
cet-13799	84	5	keep	keep	VERB
cet-13799	84	6	highly	highly	ADV
cet-13799	84	7	nonlinear	nonlinear	ADJ
cet-13799	84	8	bioprocesses	bioprocesse	NOUN
cet-13799	84	9	in	in	ADP
cet-13799	84	10	optimal	optimal	ADJ
cet-13799	84	11	conditions	condition	NOUN
cet-13799	84	12	with	with	ADP
cet-13799	84	13	adaptive	adaptive	ADJ
cet-13799	84	14	control	control	NOUN
cet-13799	84	15	strategies	strategy	NOUN
cet-13799	84	16	(	(	PUNCT
cet-13799	84	17	e.g.	e.g.	ADV
cet-13799	84	18	,	,	PUNCT
cet-13799	84	19	feeding	feed	VERB
cet-13799	84	20	profiles	profile	NOUN
cet-13799	84	21	)	)	PUNCT
cet-13799	84	22	.	.	PUNCT
cet-13799	85	1	regarding	regard	VERB
cet-13799	85	2	spm	spm	PROPN
cet-13799	85	3	,	,	PUNCT
cet-13799	85	4	soft	soft	ADJ
cet-13799	85	5	sensors	sensor	NOUN
cet-13799	85	6	can	can	AUX
cet-13799	85	7	prevent	prevent	VERB
cet-13799	85	8	defects	defect	NOUN
cet-13799	85	9	due	due	ADJ
cet-13799	85	10	to	to	ADP
cet-13799	85	11	contamination	contamination	NOUN
cet-13799	85	12	,	,	PUNCT
cet-13799	85	13	detect	detect	VERB
cet-13799	85	14	changes	change	NOUN
cet-13799	85	15	in	in	ADP
cet-13799	85	16	product	product	NOUN
cet-13799	85	17	quality	quality	NOUN
cet-13799	85	18	in	in	ADP
cet-13799	85	19	real	real	ADJ
cet-13799	85	20	-	-	PUNCT
cet-13799	85	21	time	time	NOUN
cet-13799	85	22	,	,	PUNCT
cet-13799	85	23	and	and	CCONJ
cet-13799	85	24	save	save	VERB
cet-13799	85	25	resources	resource	NOUN
cet-13799	85	26	through	through	ADP
cet-13799	85	27	optimized	optimize	VERB
cet-13799	85	28	process	process	NOUN
cet-13799	85	29	control	control	NOUN
cet-13799	85	30	(	(	PUNCT
cet-13799	85	31	figure	figure	NOUN
cet-13799	85	32	2	2	NUM
cet-13799	85	33	)	)	PUNCT
cet-13799	85	34	.	.	PUNCT
cet-13799	86	1	figure	figure	VERB
cet-13799	86	2	2	2	NUM
cet-13799	86	3	:	:	PUNCT
cet-13799	86	4	digitalization	digitalization	NOUN
cet-13799	86	5	key	key	NOUN
cet-13799	86	6	enablers	enabler	NOUN
cet-13799	86	7	and	and	CCONJ
cet-13799	86	8	their	their	PRON
cet-13799	86	9	effect	effect	NOUN
cet-13799	86	10	on	on	ADP
cet-13799	86	11	green	green	ADJ
cet-13799	86	12	metrics	metric	NOUN
cet-13799	86	13	4.3	4.3	NUM
cet-13799	86	14	predictive	predictive	ADJ
cet-13799	86	15	potential	potential	NOUN
cet-13799	86	16	and	and	CCONJ
cet-13799	86	17	process	process	NOUN
cet-13799	86	18	monitoring	monitoring	NOUN
cet-13799	86	19	of	of	ADP
cet-13799	86	20	digital	digital	ADJ
cet-13799	86	21	twins	twin	NOUN
cet-13799	86	22	(	(	PUNCT
cet-13799	86	23	dts	dts	NOUN
cet-13799	86	24	)	)	PUNCT
cet-13799	86	25	continuous	continuous	ADJ
cet-13799	86	26	manufacturing	manufacturing	NOUN
cet-13799	86	27	is	be	AUX
cet-13799	86	28	a	a	DET
cet-13799	86	29	key	key	ADJ
cet-13799	86	30	enabler	enabler	NOUN
cet-13799	86	31	of	of	ADP
cet-13799	86	32	intensified	intensified	ADJ
cet-13799	86	33	processing	processing	NOUN
cet-13799	86	34	.	.	PUNCT
cet-13799	87	1	intensification	intensification	NOUN
cet-13799	87	2	comprises	comprise	VERB
cet-13799	87	3	concepts	concept	NOUN
cet-13799	87	4	of	of	ADP
cet-13799	87	5	flow	flow	NOUN
cet-13799	87	6	processing	processing	NOUN
cet-13799	87	7	(	(	PUNCT
cet-13799	87	8	continuous	continuous	ADJ
cet-13799	87	9	)	)	PUNCT
cet-13799	87	10	,	,	PUNCT
cet-13799	87	11	process	process	NOUN
cet-13799	87	12	integration	integration	NOUN
cet-13799	87	13	(	(	PUNCT
cet-13799	87	14	cycles	cycle	NOUN
cet-13799	87	15	and	and	CCONJ
cet-13799	87	16	heat	heat	NOUN
cet-13799	87	17	integration	integration	NOUN
cet-13799	87	18	)	)	PUNCT
cet-13799	87	19	and	and	CCONJ
cet-13799	87	20	novel	novel	ADJ
cet-13799	87	21	equipment	equipment	NOUN
cet-13799	87	22	designs	design	NOUN
cet-13799	87	23	(	(	PUNCT
cet-13799	87	24	membrane	membrane	NOUN
cet-13799	87	25	reactors	reactor	NOUN
cet-13799	87	26	)	)	PUNCT
cet-13799	87	27	to	to	PART
cet-13799	87	28	achieve	achieve	VERB
cet-13799	87	29	higher	high	ADJ
cet-13799	87	30	space	space	NOUN
cet-13799	87	31	-	-	PUNCT
cet-13799	87	32	time	time	NOUN
cet-13799	87	33	yields	yield	NOUN
cet-13799	87	34	and	and	CCONJ
cet-13799	87	35	increase	increase	VERB
cet-13799	87	36	overall	overall	ADJ
cet-13799	87	37	efficiencies	efficiency	NOUN
cet-13799	87	38	(	(	PUNCT
cet-13799	87	39	boodhoo	boodhoo	NOUN
cet-13799	87	40	and	and	CCONJ
cet-13799	87	41	harvey	harvey	NOUN
cet-13799	87	42	,	,	PUNCT
cet-13799	87	43	2013	2013	NUM
cet-13799	87	44	)	)	PUNCT
cet-13799	87	45	.	.	PUNCT
cet-13799	88	1	while	while	SCONJ
cet-13799	88	2	cbm	cbm	PROPN
cet-13799	88	3	is	be	AUX
cet-13799	88	4	an	an	DET
cet-13799	88	5	established	establish	VERB
cet-13799	88	6	mode	mode	NOUN
cet-13799	88	7	in	in	ADP
cet-13799	88	8	the	the	DET
cet-13799	88	9	chemical	chemical	NOUN
cet-13799	88	10	industry	industry	NOUN
cet-13799	88	11	,	,	PUNCT
cet-13799	88	12	many	many	ADJ
cet-13799	88	13	pharmaceutical	pharmaceutical	ADJ
cet-13799	88	14	processes	process	NOUN
cet-13799	88	15	still	still	ADV
cet-13799	88	16	run	run	VERB
cet-13799	88	17	in	in	ADP
cet-13799	88	18	batch	batch	NOUN
cet-13799	88	19	mode	mode	NOUN
cet-13799	88	20	despite	despite	SCONJ
cet-13799	88	21	the	the	DET
cet-13799	88	22	benefits	benefit	NOUN
cet-13799	88	23	of	of	ADP
cet-13799	88	24	intensified	intensify	VERB
cet-13799	88	25	continuous	continuous	ADJ
cet-13799	88	26	operation	operation	NOUN
cet-13799	88	27	.	.	PUNCT
cet-13799	89	1	regulatory	regulatory	ADJ
cet-13799	89	2	authorities	authority	NOUN
cet-13799	89	3	(	(	PUNCT
cet-13799	89	4	fda	fda	PROPN
cet-13799	89	5	,	,	PUNCT
cet-13799	89	6	ema	ema	PROPN
cet-13799	89	7	)	)	PUNCT
cet-13799	89	8	set	set	VERB
cet-13799	89	9	high	high	ADJ
cet-13799	89	10	standards	standard	NOUN
cet-13799	89	11	in	in	ADP
cet-13799	89	12	the	the	DET
cet-13799	89	13	pharmaceutical	pharmaceutical	ADJ
cet-13799	89	14	industry	industry	NOUN
cet-13799	89	15	to	to	PART
cet-13799	89	16	guarantee	guarantee	VERB
cet-13799	89	17	the	the	DET
cet-13799	89	18	safety	safety	NOUN
cet-13799	89	19	and	and	CCONJ
cet-13799	89	20	efficacy	efficacy	NOUN
cet-13799	89	21	of	of	ADP
cet-13799	89	22	drugs	drug	NOUN
cet-13799	89	23	but	but	CCONJ
cet-13799	89	24	explicitly	explicitly	ADV
cet-13799	89	25	encourage	encourage	VERB
cet-13799	89	26	enabling	enable	VERB
cet-13799	89	27	continuous	continuous	ADJ
cet-13799	89	28	manufacturing	manufacturing	NOUN
cet-13799	89	29	lines	line	NOUN
cet-13799	89	30	(	(	PUNCT
cet-13799	89	31	sommeregger	sommeregger	PROPN
cet-13799	89	32	et	et	PROPN
cet-13799	89	33	al	al	PROPN
cet-13799	89	34	.	.	PROPN
cet-13799	89	35	,	,	PUNCT
cet-13799	89	36	2017	2017	NUM
cet-13799	89	37	)	)	PUNCT
cet-13799	89	38	.	.	PUNCT
cet-13799	90	1	however	however	ADV
cet-13799	90	2	,	,	PUNCT
cet-13799	90	3	quality	quality	NOUN
cet-13799	90	4	assurance	assurance	NOUN
cet-13799	90	5	can	can	AUX
cet-13799	90	6	not	not	PART
cet-13799	90	7	be	be	AUX
cet-13799	90	8	done	do	VERB
cet-13799	90	9	in	in	ADP
cet-13799	90	10	the	the	DET
cet-13799	90	11	traditional	traditional	ADJ
cet-13799	90	12	approach	approach	NOUN
cet-13799	90	13	by	by	ADP
cet-13799	90	14	testing	test	VERB
cet-13799	90	15	the	the	DET
cet-13799	90	16	batch	batch	NOUN
cet-13799	90	17	quality	quality	NOUN
cet-13799	90	18	of	of	ADP
cet-13799	90	19	products	product	NOUN
cet-13799	90	20	or	or	CCONJ
cet-13799	90	21	intermediates	intermediate	NOUN
cet-13799	90	22	.	.	PUNCT
cet-13799	91	1	instead	instead	ADV
cet-13799	91	2	,	,	PUNCT
cet-13799	91	3	continuous	continuous	ADJ
cet-13799	91	4	monitoring	monitoring	NOUN
cet-13799	91	5	of	of	ADP
cet-13799	91	6	quality	quality	NOUN
cet-13799	91	7	gates	gate	NOUN
cet-13799	91	8	is	be	AUX
cet-13799	91	9	required	require	VERB
cet-13799	91	10	.	.	PUNCT
cet-13799	92	1	since	since	SCONJ
cet-13799	92	2	varying	vary	VERB
cet-13799	92	3	inlet	inlet	ADJ
cet-13799	92	4	streams	stream	NOUN
cet-13799	92	5	(	(	PUNCT
cet-13799	92	6	cmas	cmas	PROPN
cet-13799	92	7	)	)	PUNCT
cet-13799	92	8	might	might	AUX
cet-13799	92	9	cause	cause	VERB
cet-13799	92	10	changes	change	NOUN
cet-13799	92	11	in	in	ADP
cet-13799	92	12	the	the	DET
cet-13799	92	13	cqas	cqas	NOUN
cet-13799	92	14	,	,	PUNCT
cet-13799	92	15	advanced	advanced	ADJ
cet-13799	92	16	control	control	NOUN
cet-13799	92	17	strategies	strategy	NOUN
cet-13799	92	18	must	must	AUX
cet-13799	92	19	be	be	AUX
cet-13799	92	20	applied	apply	VERB
cet-13799	92	21	.	.	PUNCT
cet-13799	93	1	to	to	PART
cet-13799	93	2	combine	combine	VERB
cet-13799	93	3	complex	complex	ADJ
cet-13799	93	4	data	datum	NOUN
cet-13799	93	5	sets	set	NOUN
cet-13799	93	6	,	,	PUNCT
cet-13799	93	7	variable	variable	ADJ
cet-13799	93	8	process	process	NOUN
cet-13799	93	9	input	input	NOUN
cet-13799	93	10	parameters	parameter	NOUN
cet-13799	93	11	,	,	PUNCT
cet-13799	93	12	dynamic	dynamic	ADJ
cet-13799	93	13	models	model	NOUN
cet-13799	93	14	,	,	PUNCT
cet-13799	93	15	advanced	advanced	ADJ
cet-13799	93	16	process	process	NOUN
cet-13799	93	17	control	control	NOUN
cet-13799	93	18	and	and	CCONJ
cet-13799	93	19	green	green	ADJ
cet-13799	93	20	metrics	metric	NOUN
cet-13799	93	21	,	,	PUNCT
cet-13799	93	22	dts	dt	NOUN
cet-13799	93	23	seem	seem	VERB
cet-13799	93	24	to	to	PART
cet-13799	93	25	have	have	VERB
cet-13799	93	26	the	the	DET
cet-13799	93	27	highest	high	ADJ
cet-13799	93	28	potential	potential	NOUN
cet-13799	93	29	as	as	ADP
cet-13799	93	30	a	a	DET
cet-13799	93	31	digital	digital	ADJ
cet-13799	93	32	shadow	shadow	NOUN
cet-13799	93	33	of	of	ADP
cet-13799	93	34	the	the	DET
cet-13799	93	35	entire	entire	ADJ
cet-13799	93	36	manufacturing	manufacturing	NOUN
cet-13799	93	37	(	(	PUNCT
cet-13799	93	38	chen	chen	PROPN
cet-13799	93	39	et	et	PROPN
cet-13799	93	40	al	al	PROPN
cet-13799	93	41	.	.	PROPN
cet-13799	93	42	,	,	PUNCT
cet-13799	93	43	2020	2020	NUM
cet-13799	93	44	)	)	PUNCT
cet-13799	93	45	.	.	PUNCT
cet-13799	94	1	dts	dts	PROPN
cet-13799	94	2	show	show	VERB
cet-13799	94	3	great	great	ADJ
cet-13799	94	4	promise	promise	NOUN
cet-13799	94	5	in	in	ADP
cet-13799	94	6	translating	translate	VERB
cet-13799	94	7	complex	complex	ADJ
cet-13799	94	8	data	datum	NOUN
cet-13799	94	9	sets	set	NOUN
cet-13799	94	10	into	into	ADP
cet-13799	94	11	robust	robust	ADJ
cet-13799	94	12	process	process	NOUN
cet-13799	94	13	knowledge	knowledge	NOUN
cet-13799	94	14	,	,	PUNCT
cet-13799	94	15	enabling	enable	VERB
cet-13799	94	16	consistent	consistent	ADJ
cet-13799	94	17	product	product	NOUN
cet-13799	94	18	quality	quality	NOUN
cet-13799	94	19	with	with	ADP
cet-13799	94	20	variable	variable	ADJ
cet-13799	94	21	process	process	NOUN
cet-13799	94	22	input	input	NOUN
cet-13799	94	23	parameters	parameter	NOUN
cet-13799	94	24	,	,	PUNCT
cet-13799	94	25	transferring	transfer	VERB
cet-13799	94	26	nonlinear	nonlinear	ADJ
cet-13799	94	27	bioprocesses	bioprocesse	NOUN
cet-13799	94	28	into	into	ADP
cet-13799	94	29	dynamic	dynamic	ADJ
cet-13799	94	30	models	model	NOUN
cet-13799	94	31	,	,	PUNCT
cet-13799	94	32	and	and	CCONJ
cet-13799	94	33	combining	combine	VERB
cet-13799	94	34	advanced	advanced	ADJ
cet-13799	94	35	process	process	NOUN
cet-13799	94	36	control	control	NOUN
cet-13799	94	37	and	and	CCONJ
cet-13799	94	38	green	green	ADJ
cet-13799	94	39	metrics	metric	NOUN
cet-13799	94	40	.	.	PUNCT
cet-13799	95	1	dts	dt	NOUN
cet-13799	95	2	are	be	AUX
cet-13799	95	3	data	datum	NOUN
cet-13799	95	4	management	management	NOUN
cet-13799	95	5	,	,	PUNCT
cet-13799	95	6	monitoring	monitoring	NOUN
cet-13799	95	7	and	and	CCONJ
cet-13799	95	8	control	control	NOUN
cet-13799	95	9	,	,	PUNCT
cet-13799	95	10	and	and	CCONJ
cet-13799	95	11	active	active	ADJ
cet-13799	95	12	decision	decision	NOUN
cet-13799	95	13	-	-	PUNCT
cet-13799	95	14	making	making	NOUN
cet-13799	95	15	in	in	ADP
cet-13799	95	16	case	case	NOUN
cet-13799	95	17	of	of	ADP
cet-13799	95	18	failures	failure	NOUN
cet-13799	95	19	(	(	PUNCT
cet-13799	95	20	early	early	ADJ
cet-13799	95	21	failure	failure	NOUN
cet-13799	95	22	detection	detection	NOUN
cet-13799	95	23	)	)	PUNCT
cet-13799	95	24	.	.	PUNCT
cet-13799	96	1	the	the	DET
cet-13799	96	2	digital	digital	ADJ
cet-13799	96	3	maturity	maturity	NOUN
cet-13799	96	4	of	of	ADP
cet-13799	96	5	a	a	DET
cet-13799	96	6	dt	dt	NOUN
cet-13799	96	7	determines	determine	VERB
cet-13799	96	8	the	the	DET
cet-13799	96	9	level	level	NOUN
cet-13799	96	10	of	of	ADP
cet-13799	96	11	integration	integration	NOUN
cet-13799	96	12	and	and	CCONJ
cet-13799	96	13	actionable	actionable	ADJ
cet-13799	96	14	decisions	decision	NOUN
cet-13799	96	15	in	in	ADP
cet-13799	96	16	a	a	DET
cet-13799	96	17	facility	facility	NOUN
cet-13799	96	18	.	.	PUNCT
cet-13799	97	1	the	the	DET
cet-13799	97	2	dt	dt	NOUN
cet-13799	97	3	is	be	AUX
cet-13799	97	4	expected	expect	VERB
cet-13799	97	5	to	to	PART
cet-13799	97	6	interact	interact	VERB
cet-13799	97	7	horizontally	horizontally	ADV
cet-13799	97	8	along	along	ADP
cet-13799	97	9	all	all	DET
cet-13799	97	10	unit	unit	NOUN
cet-13799	97	11	operations	operation	NOUN
cet-13799	97	12	and	and	CCONJ
cet-13799	97	13	vertically	vertically	ADV
cet-13799	97	14	from	from	ADP
cet-13799	97	15	operator	operator	NOUN
cet-13799	97	16	instructions	instruction	NOUN
cet-13799	97	17	to	to	ADP
cet-13799	97	18	global	global	ADJ
cet-13799	97	19	supply	supply	NOUN
cet-13799	97	20	chains	chain	NOUN
cet-13799	97	21	(	(	PUNCT
cet-13799	97	22	arden	arden	PROPN
cet-13799	97	23	et	et	PROPN
cet-13799	97	24	al	al	PROPN
cet-13799	97	25	.	.	PROPN
cet-13799	97	26	,	,	PUNCT
cet-13799	97	27	2021	2021	NUM
cet-13799	97	28	)	)	PUNCT
cet-13799	97	29	.	.	PUNCT
cet-13799	98	1	hereby	hereby	ADV
cet-13799	98	2	,	,	PUNCT
cet-13799	98	3	an	an	DET
cet-13799	98	4	ongoing	ongoing	ADJ
cet-13799	98	5	challenge	challenge	NOUN
cet-13799	98	6	is	be	AUX
cet-13799	98	7	the	the	DET
cet-13799	98	8	full	full	ADJ
cet-13799	98	9	integration	integration	NOUN
cet-13799	98	10	of	of	ADP
cet-13799	98	11	upstream	upstream	ADJ
cet-13799	98	12	and	and	CCONJ
cet-13799	98	13	downstream	downstream	ADJ
cet-13799	98	14	unit	unit	NOUN
cet-13799	98	15	operations	operation	NOUN
cet-13799	98	16	(	(	PUNCT
cet-13799	98	17	hong	hong	NOUN
cet-13799	98	18	et	et	PROPN
cet-13799	98	19	al	al	PROPN
cet-13799	98	20	.	.	PROPN
cet-13799	98	21	,	,	PUNCT
cet-13799	98	22	2018	2018	NUM
cet-13799	98	23	)	)	PUNCT
cet-13799	98	24	.	.	PUNCT
cet-13799	99	1	the	the	DET
cet-13799	99	2	predictive	predictive	ADJ
cet-13799	99	3	potential	potential	NOUN
cet-13799	99	4	of	of	ADP
cet-13799	99	5	a	a	DET
cet-13799	99	6	dt	dt	NOUN
cet-13799	99	7	will	will	AUX
cet-13799	99	8	enhance	enhance	VERB
cet-13799	99	9	the	the	DET
cet-13799	99	10	integration	integration	NOUN
cet-13799	99	11	of	of	ADP
cet-13799	99	12	364	364	NUM
cet-13799	99	13	unit	unit	NOUN
cet-13799	99	14	operations	operation	NOUN
cet-13799	99	15	by	by	ADP
cet-13799	99	16	enabling	enable	VERB
cet-13799	99	17	real	real	ADJ
cet-13799	99	18	-	-	PUNCT
cet-13799	99	19	time	time	NOUN
cet-13799	99	20	tracking	tracking	NOUN
cet-13799	99	21	of	of	ADP
cet-13799	99	22	cpps	cpps	NOUN
cet-13799	99	23	,	,	PUNCT
cet-13799	99	24	observing	observe	VERB
cet-13799	99	25	quality	quality	NOUN
cet-13799	99	26	-	-	PUNCT
cet-13799	99	27	related	relate	VERB
cet-13799	99	28	attributes	attribute	NOUN
cet-13799	99	29	throughout	throughout	ADP
cet-13799	99	30	the	the	DET
cet-13799	99	31	whole	whole	ADJ
cet-13799	99	32	process	process	NOUN
cet-13799	99	33	,	,	PUNCT
cet-13799	99	34	propagating	propagate	VERB
cet-13799	99	35	deviations	deviation	NOUN
cet-13799	99	36	,	,	PUNCT
cet-13799	99	37	and	and	CCONJ
cet-13799	99	38	evaluating	evaluate	VERB
cet-13799	99	39	risks	risk	NOUN
cet-13799	99	40	.	.	PUNCT
cet-13799	100	1	by	by	ADP
cet-13799	100	2	merging	merge	VERB
cet-13799	100	3	the	the	DET
cet-13799	100	4	entire	entire	ADJ
cet-13799	100	5	data	datum	NOUN
cet-13799	100	6	set	set	VERB
cet-13799	100	7	and	and	CCONJ
cet-13799	100	8	smart	smart	ADJ
cet-13799	100	9	data	datum	NOUN
cet-13799	100	10	management	management	NOUN
cet-13799	100	11	in	in	ADP
cet-13799	100	12	the	the	DET
cet-13799	100	13	dt	dt	PROPN
cet-13799	100	14	,	,	PUNCT
cet-13799	100	15	significant	significant	ADJ
cet-13799	100	16	efficiency	efficiency	NOUN
cet-13799	100	17	gains	gain	NOUN
cet-13799	100	18	are	be	AUX
cet-13799	100	19	also	also	ADV
cet-13799	100	20	anticipated	anticipate	VERB
cet-13799	100	21	through	through	ADP
cet-13799	100	22	adaptive	adaptive	ADJ
cet-13799	100	23	process	process	NOUN
cet-13799	100	24	control	control	NOUN
cet-13799	100	25	and	and	CCONJ
cet-13799	100	26	the	the	DET
cet-13799	100	27	incorporation	incorporation	NOUN
cet-13799	100	28	of	of	ADP
cet-13799	100	29	green	green	ADJ
cet-13799	100	30	metrics	metric	NOUN
cet-13799	100	31	.	.	PUNCT
cet-13799	101	1	5	5	X
cet-13799	101	2	.	.	X
cet-13799	101	3	conclusions	conclusion	NOUN
cet-13799	101	4	the	the	DET
cet-13799	101	5	tools	tool	NOUN
cet-13799	101	6	pat	pat	NOUN
cet-13799	101	7	,	,	PUNCT
cet-13799	101	8	soft	soft	ADJ
cet-13799	101	9	sensors	sensor	NOUN
cet-13799	101	10	and	and	CCONJ
cet-13799	101	11	dts	dts	NOUN
cet-13799	101	12	are	be	AUX
cet-13799	101	13	the	the	DET
cet-13799	101	14	primary	primary	ADJ
cet-13799	101	15	enablers	enabler	NOUN
cet-13799	101	16	of	of	ADP
cet-13799	101	17	digitalization	digitalization	NOUN
cet-13799	101	18	in	in	ADP
cet-13799	101	19	the	the	DET
cet-13799	101	20	(	(	PUNCT
cet-13799	101	21	bio-	bio-	ADJ
cet-13799	101	22	)	)	PUNCT
cet-13799	101	23	pharmaceutical	pharmaceutical	NOUN
cet-13799	101	24	industry	industry	NOUN
cet-13799	101	25	.	.	PUNCT
cet-13799	102	1	in	in	ADP
cet-13799	102	2	this	this	DET
cet-13799	102	3	contribution	contribution	NOUN
cet-13799	102	4	,	,	PUNCT
cet-13799	102	5	the	the	DET
cet-13799	102	6	usage	usage	NOUN
cet-13799	102	7	of	of	ADP
cet-13799	102	8	those	those	DET
cet-13799	102	9	enablers	enabler	NOUN
cet-13799	102	10	for	for	ADP
cet-13799	102	11	greener	green	ADJ
cet-13799	102	12	pharmaceutical	pharmaceutical	ADJ
cet-13799	102	13	manufacturing	manufacturing	NOUN
cet-13799	102	14	was	be	AUX
cet-13799	102	15	analyzed	analyze	VERB
cet-13799	102	16	.	.	PUNCT
cet-13799	103	1	green	green	ADJ
cet-13799	103	2	metrics	metric	NOUN
cet-13799	103	3	are	be	AUX
cet-13799	103	4	required	require	VERB
cet-13799	103	5	to	to	PART
cet-13799	103	6	design	design	VERB
cet-13799	103	7	new	new	ADJ
cet-13799	103	8	processes	process	NOUN
cet-13799	103	9	and	and	CCONJ
cet-13799	103	10	benchmark	benchmark	NOUN
cet-13799	103	11	with	with	ADP
cet-13799	103	12	traditional	traditional	ADJ
cet-13799	103	13	manufacturing	manufacturing	NOUN
cet-13799	103	14	.	.	PUNCT
cet-13799	104	1	the	the	DET
cet-13799	104	2	green	green	ADJ
cet-13799	104	3	metrics	metric	NOUN
cet-13799	104	4	pmi	pmi	NOUN
cet-13799	104	5	,	,	PUNCT
cet-13799	104	6	e	e	NOUN
cet-13799	104	7	-	-	NOUN
cet-13799	104	8	factor	factor	NOUN
cet-13799	104	9	and	and	CCONJ
cet-13799	104	10	warien	warien	NOUN
cet-13799	104	11	are	be	AUX
cet-13799	104	12	process	process	NOUN
cet-13799	104	13	-	-	PUNCT
cet-13799	104	14	independent	independent	ADJ
cet-13799	104	15	and	and	CCONJ
cet-13799	104	16	are	be	AUX
cet-13799	104	17	applicable	applicable	ADJ
cet-13799	104	18	for	for	ADP
cet-13799	104	19	characterizing	characterizing	NOUN
cet-13799	104	20	,	,	PUNCT
cet-13799	104	21	evaluating	evaluating	NOUN
cet-13799	104	22	,	,	PUNCT
cet-13799	104	23	or	or	CCONJ
cet-13799	104	24	benchmarking	benchmarke	VERB
cet-13799	104	25	pharmaceutical	pharmaceutical	ADJ
cet-13799	104	26	production	production	NOUN
cet-13799	104	27	.	.	PUNCT
cet-13799	105	1	however	however	ADV
cet-13799	105	2	,	,	PUNCT
cet-13799	105	3	green	green	ADJ
cet-13799	105	4	metrics	metric	NOUN
cet-13799	105	5	is	be	AUX
cet-13799	105	6	an	an	DET
cet-13799	105	7	evolving	evolve	VERB
cet-13799	105	8	field	field	NOUN
cet-13799	105	9	.	.	PUNCT
cet-13799	106	1	new	new	ADJ
cet-13799	106	2	metrics	metric	NOUN
cet-13799	106	3	should	should	AUX
cet-13799	106	4	be	be	AUX
cet-13799	106	5	introduced	introduce	VERB
cet-13799	106	6	for	for	ADP
cet-13799	106	7	a	a	DET
cet-13799	106	8	more	more	ADV
cet-13799	106	9	holistic	holistic	ADJ
cet-13799	106	10	process	process	NOUN
cet-13799	106	11	perspective	perspective	NOUN
cet-13799	106	12	on	on	ADP
cet-13799	106	13	sustainability	sustainability	NOUN
cet-13799	106	14	.	.	PUNCT
cet-13799	107	1	the	the	DET
cet-13799	107	2	consistent	consistent	ADJ
cet-13799	107	3	characterization	characterization	NOUN
cet-13799	107	4	of	of	ADP
cet-13799	107	5	process	process	NOUN
cet-13799	107	6	development	development	NOUN
cet-13799	107	7	and	and	CCONJ
cet-13799	107	8	industrial	industrial	ADJ
cet-13799	107	9	manufacturing	manufacturing	NOUN
cet-13799	107	10	regarding	regard	VERB
cet-13799	107	11	environmental	environmental	ADJ
cet-13799	107	12	impact	impact	NOUN
cet-13799	107	13	reduction	reduction	NOUN
cet-13799	107	14	is	be	AUX
cet-13799	107	15	unavailable	unavailable	ADJ
cet-13799	107	16	.	.	PUNCT
cet-13799	108	1	the	the	DET
cet-13799	108	2	increasing	increase	VERB
cet-13799	108	3	sensitivity	sensitivity	NOUN
cet-13799	108	4	of	of	ADP
cet-13799	108	5	society	society	NOUN
cet-13799	108	6	to	to	ADP
cet-13799	108	7	greener	green	ADJ
cet-13799	108	8	products	product	NOUN
cet-13799	108	9	combined	combine	VERB
cet-13799	108	10	with	with	ADP
cet-13799	108	11	economic	economic	ADJ
cet-13799	108	12	pressure	pressure	NOUN
cet-13799	108	13	due	due	ADP
cet-13799	108	14	to	to	ADP
cet-13799	108	15	higher	high	ADJ
cet-13799	108	16	co2	co2	NOUN
cet-13799	108	17	certificate	certificate	NOUN
cet-13799	108	18	prices	price	NOUN
cet-13799	108	19	will	will	AUX
cet-13799	108	20	lead	lead	VERB
cet-13799	108	21	to	to	ADP
cet-13799	108	22	a	a	DET
cet-13799	108	23	shifted	shift	VERB
cet-13799	108	24	focus	focus	NOUN
cet-13799	108	25	towards	towards	ADP
cet-13799	108	26	sustainable	sustainable	ADJ
cet-13799	108	27	manufacturing	manufacturing	NOUN
cet-13799	108	28	.	.	PUNCT
cet-13799	109	1	nomenclature	nomenclature	ADJ
cet-13799	109	2	cbm	cbm	PROPN
cet-13799	109	3	–	–	PUNCT
cet-13799	109	4	continuous	continuous	ADJ
cet-13799	109	5	biomanufacturing	biomanufacturing	NOUN
cet-13799	109	6	cma	cma	NOUN
cet-13799	109	7	–	–	PUNCT
cet-13799	109	8	critical	critical	ADJ
cet-13799	109	9	raw	raw	ADJ
cet-13799	109	10	material	material	NOUN
cet-13799	109	11	attribute	attribute	NOUN
cet-13799	109	12	cpp	cpp	PROPN
cet-13799	109	13	–	–	PUNCT
cet-13799	109	14	critical	critical	ADJ
cet-13799	109	15	process	process	NOUN
cet-13799	109	16	parameter	parameter	NOUN
cet-13799	109	17	cps	cps	PROPN
cet-13799	109	18	–	–	PUNCT
cet-13799	109	19	cyber	cyber	NOUN
cet-13799	109	20	-	-	PUNCT
cet-13799	109	21	physical	physical	ADJ
cet-13799	109	22	system	system	NOUN
cet-13799	109	23	cqa	cqa	ADV
cet-13799	109	24	–	–	PUNCT
cet-13799	109	25	critical	critical	ADJ
cet-13799	109	26	quality	quality	NOUN
cet-13799	109	27	attribute	attribute	NOUN
cet-13799	109	28	dt	dt	PROPN
cet-13799	109	29	–	–	PUNCT
cet-13799	109	30	digital	digital	ADJ
cet-13799	109	31	twin	twin	ADJ
cet-13799	109	32	e	e	NOUN
cet-13799	109	33	-	-	NOUN
cet-13799	109	34	factor	factor	NOUN
cet-13799	109	35	–	–	PUNCT
cet-13799	109	36	environmental	environmental	ADJ
cet-13799	109	37	factor	factor	NOUN
cet-13799	109	38	ema	ema	PROPN
cet-13799	109	39	–	–	PUNCT
cet-13799	109	40	european	european	PROPN
cet-13799	109	41	medicines	medicine	NOUN
cet-13799	109	42	agency	agency	NOUN
cet-13799	109	43	fda	fda	PROPN
cet-13799	109	44	–	–	PUNCT
cet-13799	109	45	food	food	NOUN
cet-13799	109	46	and	and	CCONJ
cet-13799	109	47	drug	drug	PROPN
cet-13799	109	48	administration	administration	NOUN
cet-13799	109	49	hplc	hplc	PROPN
cet-13799	109	50	–	–	PUNCT
cet-13799	109	51	high	high	ADJ
cet-13799	109	52	-	-	PUNCT
cet-13799	109	53	performance	performance	NOUN
cet-13799	109	54	liquid	liquid	ADJ
cet-13799	109	55	chromatography	chromatography	NOUN
cet-13799	109	56	i3.0	i3.0	NOUN
cet-13799	109	57	–	–	PUNCT
cet-13799	109	58	industry	industry	NOUN
cet-13799	109	59	3.0	3.0	NUM
cet-13799	109	60	i4.0	i4.0	X
cet-13799	109	61	–	–	PUNCT
cet-13799	109	62	industry	industry	NOUN
cet-13799	109	63	4.0	4.0	NUM
cet-13799	109	64	iot	iot	NOUN
cet-13799	109	65	–	–	PUNCT
cet-13799	109	66	internet	internet	NOUN
cet-13799	109	67	of	of	ADP
cet-13799	109	68	things	thing	NOUN
cet-13799	109	69	lca	lca	PROPN
cet-13799	109	70	–	–	PUNCT
cet-13799	109	71	lifecycle	lifecycle	NOUN
cet-13799	109	72	assessment	assessment	NOUN
cet-13799	109	73	m3c	m3c	PROPN
cet-13799	109	74	–	–	PUNCT
cet-13799	109	75	measurement	measurement	NOUN
cet-13799	109	76	,	,	PUNCT
cet-13799	109	77	monitoring	monitoring	NOUN
cet-13799	109	78	,	,	PUNCT
cet-13799	109	79	modeling	modeling	NOUN
cet-13799	109	80	and	and	CCONJ
cet-13799	109	81	control	control	NOUN
cet-13799	109	82	ms	ms	PROPN
cet-13799	109	83	–	–	PUNCT
cet-13799	109	84	mass	mass	NOUN
cet-13799	109	85	spectroscopy	spectroscopy	NOUN
cet-13799	109	86	nir	nir	NOUN
cet-13799	109	87	–	–	PUNCT
cet-13799	109	88	near	near	ADV
cet-13799	109	89	-	-	PUNCT
cet-13799	109	90	infrared	infrared	ADJ
cet-13799	109	91	spectroscopy	spectroscopy	NOUN
cet-13799	109	92	pat	pat	NOUN
cet-13799	109	93	–	–	PUNCT
cet-13799	109	94	process	process	NOUN
cet-13799	109	95	analytical	analytical	ADJ
cet-13799	109	96	technology	technology	NOUN
cet-13799	109	97	pmi	pmi	PROPN
cet-13799	109	98	–	–	PUNCT
cet-13799	109	99	process	process	NOUN
cet-13799	109	100	mass	mass	NOUN
cet-13799	109	101	intensity	intensity	NOUN
cet-13799	109	102	qbd	qbd	INTJ
cet-13799	109	103	–	–	PUNCT
cet-13799	109	104	quality	quality	NOUN
cet-13799	109	105	-	-	PUNCT
cet-13799	109	106	by	by	ADP
cet-13799	109	107	-	-	PUNCT
cet-13799	109	108	design	design	NOUN
cet-13799	109	109	spm	spm	PROPN
cet-13799	109	110	–	–	PUNCT
cet-13799	109	111	sustainable	sustainable	ADJ
cet-13799	109	112	pharmaceutical	pharmaceutical	NOUN
cet-13799	109	113	manufacturing	manufacturing	NOUN
cet-13799	109	114	vcc	vcc	NOUN
cet-13799	109	115	–	–	PUNCT
cet-13799	109	116	viable	viable	ADJ
cet-13799	109	117	cell	cell	NOUN
cet-13799	109	118	count	count	NOUN
cet-13799	109	119	warien	warien	NOUN
cet-13799	109	120	–	–	PUNCT
cet-13799	109	121	water	water	NOUN
cet-13799	109	122	-	-	PUNCT
cet-13799	109	123	related	relate	VERB
cet-13799	109	124	impact	impact	NOUN
cet-13799	109	125	of	of	ADP
cet-13799	109	126	energy	energy	NOUN
cet-13799	109	127	acknowledgements	acknowledgement	NOUN
cet-13799	109	128	the	the	DET
cet-13799	109	129	authors	author	NOUN
cet-13799	109	130	would	would	AUX
cet-13799	109	131	like	like	VERB
cet-13799	109	132	to	to	PART
cet-13799	109	133	acknowledge	acknowledge	VERB
cet-13799	109	134	the	the	DET
cet-13799	109	135	financial	financial	ADJ
cet-13799	109	136	support	support	NOUN
cet-13799	109	137	the	the	DET
cet-13799	109	138	eu	eu	PROPN
cet-13799	109	139	horizon	horizon	PROPN
cet-13799	109	140	project	project	NOUN
cet-13799	109	141	enviromed	envirome	VERB
cet-13799	109	142	provided	provide	VERB
cet-13799	109	143	under	under	ADP
cet-13799	109	144	grant	grant	NOUN
cet-13799	109	145	agreement	agreement	NOUN
cet-13799	109	146	i	i	PRON
cet-13799	109	147	d	d	PROPN
cet-13799	109	148	:	:	PUNCT
cet-13799	109	149	101057844	101057844	NUM
cet-13799	109	150	.	.	PUNCT
cet-13799	110	1	references	reference	NOUN
cet-13799	110	2	arden	arden	PROPN
cet-13799	110	3	n.s	n.s	PROPN
cet-13799	110	4	.	.	PROPN
cet-13799	110	5	,	,	PUNCT
cet-13799	110	6	fisher	fisher	PROPN
cet-13799	110	7	a.c	a.c	PROPN
cet-13799	110	8	.	.	PROPN
cet-13799	110	9	,	,	PUNCT
cet-13799	110	10	tyner	tyner	PROPN
cet-13799	110	11	k.	k.	PROPN
cet-13799	110	12	,	,	PUNCT
cet-13799	110	13	yu	yu	PROPN
cet-13799	110	14	l.x	l.x	PROPN
cet-13799	110	15	.	.	PROPN
cet-13799	110	16	,	,	PUNCT
cet-13799	110	17	lee	lee	PROPN
cet-13799	110	18	s.l	s.l	PROPN
cet-13799	110	19	.	.	PROPN
cet-13799	110	20	and	and	CCONJ
cet-13799	110	21	kopcha	kopcha	PROPN
cet-13799	110	22	m.	m.	NOUN
cet-13799	110	23	,	,	PUNCT
cet-13799	110	24	2021	2021	NUM
cet-13799	110	25	,	,	PUNCT
cet-13799	110	26	industry	industry	NOUN
cet-13799	110	27	4.0	4.0	NUM
cet-13799	110	28	for	for	ADP
cet-13799	110	29	pharmaceutical	pharmaceutical	ADJ
cet-13799	110	30	manufacturing	manufacturing	NOUN
cet-13799	110	31	:	:	PUNCT
cet-13799	110	32	preparing	prepare	VERB
cet-13799	110	33	for	for	ADP
cet-13799	110	34	the	the	DET
cet-13799	110	35	smart	smart	ADJ
cet-13799	110	36	factories	factory	NOUN
cet-13799	110	37	of	of	ADP
cet-13799	110	38	the	the	DET
cet-13799	110	39	future	future	NOUN
cet-13799	110	40	,	,	PUNCT
cet-13799	110	41	international	international	ADJ
cet-13799	110	42	journal	journal	NOUN
cet-13799	110	43	of	of	ADP
cet-13799	110	44	pharmaceutics	pharmaceutic	NOUN
cet-13799	110	45	,	,	PUNCT
cet-13799	110	46	602	602	NUM
cet-13799	110	47	,	,	PUNCT
cet-13799	110	48	p.120554	p.120554	PROPN
cet-13799	110	49	.	.	PUNCT
cet-13799	110	50	barenji	barenji	PROPN
cet-13799	110	51	r.v	r.v	PROPN
cet-13799	110	52	.	.	PROPN
cet-13799	110	53	,	,	PUNCT
cet-13799	110	54	akdag	akdag	PROPN
cet-13799	110	55	y.	y.	PROPN
cet-13799	110	56	,	,	PUNCT
cet-13799	110	57	yet	yet	ADV
cet-13799	110	58	b.	b.	PROPN
cet-13799	110	59	and	and	CCONJ
cet-13799	110	60	oner	oner	VERB
cet-13799	110	61	l.	l.	PROPN
cet-13799	110	62	,	,	PUNCT
cet-13799	110	63	2019	2019	NUM
cet-13799	110	64	,	,	PUNCT
cet-13799	110	65	cyber	cyber	NOUN
cet-13799	110	66	-	-	PUNCT
cet-13799	110	67	physical	physical	NOUN
cet-13799	110	68	-	-	PUNCT
cet-13799	110	69	based	base	VERB
cet-13799	110	70	pat	pat	NOUN
cet-13799	110	71	(	(	PUNCT
cet-13799	110	72	cpbpat	cpbpat	NOUN
cet-13799	110	73	)	)	PUNCT
cet-13799	110	74	framework	framework	NOUN
cet-13799	110	75	for	for	ADP
cet-13799	110	76	pharma	pharma	PROPN
cet-13799	110	77	4.0	4.0	NUM
cet-13799	110	78	,	,	PUNCT
cet-13799	110	79	international	international	ADJ
cet-13799	110	80	journal	journal	NOUN
cet-13799	110	81	of	of	ADP
cet-13799	110	82	pharmaceutics	pharmaceutic	NOUN
cet-13799	110	83	,	,	PUNCT
cet-13799	110	84	567	567	NUM
cet-13799	110	85	,	,	PUNCT
cet-13799	110	86	p.118445	p.118445	NOUN
cet-13799	110	87	.	.	PUNCT
cet-13799	111	1	bmbf	bmbf	NOUN
cet-13799	111	2	,	,	PUNCT
cet-13799	111	3	2016	2016	NUM
cet-13799	111	4	,	,	PUNCT
cet-13799	111	5	industry	industry	NOUN
cet-13799	111	6	4.0	4.0	NUM
cet-13799	111	7	,	,	PUNCT
cet-13799	111	8	bundesministerium	bundesministerium	NOUN
cet-13799	111	9	für	für	NOUN
cet-13799	111	10	bildung	bildung	PROPN
cet-13799	111	11	und	und	PROPN
cet-13799	111	12	forschung	forschung	ADJ
cet-13799	111	13	bmbf	bmbf	NOUN
cet-13799	111	14	.	.	PUNCT
cet-13799	112	1	<	<	X
cet-13799	112	2	https://www.bmbf.de/bmbf/de/forschung/digitale-wirtschaft-und-gesellschaft/industrie-4-0/industrie-40.html	https://www.bmbf.de/bmbf/de/forschung/digitale-wirtschaft-und-gesellschaft/industrie-4-0/industrie-40.html	X
cet-13799	112	3	>	>	X
cet-13799	112	4	accessed	access	VERB
cet-13799	112	5	14.02.2023	14.02.2023	NUM
cet-13799	112	6	.	.	PUNCT
cet-13799	113	1	(	(	PUNCT
cet-13799	113	2	in	in	ADP
cet-13799	113	3	german	german	ADJ
cet-13799	113	4	)	)	PUNCT
cet-13799	113	5	boodhoo	boodhoo	PROPN
cet-13799	113	6	k.	k.	PROPN
cet-13799	113	7	and	and	CCONJ
cet-13799	113	8	harvey	harvey	PROPN
cet-13799	113	9	a.	a.	PROPN
cet-13799	113	10	,	,	PUNCT
cet-13799	113	11	2013	2013	NUM
cet-13799	113	12	,	,	PUNCT
cet-13799	113	13	process	process	NOUN
cet-13799	113	14	intensification	intensification	NOUN
cet-13799	113	15	:	:	PUNCT
cet-13799	113	16	an	an	DET
cet-13799	113	17	overview	overview	NOUN
cet-13799	113	18	of	of	ADP
cet-13799	113	19	principles	principle	NOUN
cet-13799	113	20	and	and	CCONJ
cet-13799	113	21	practice	practice	NOUN
cet-13799	113	22	,	,	PUNCT
cet-13799	113	23	in	in	ADP
cet-13799	113	24	:	:	PUNCT
cet-13799	113	25	k.	k.	PROPN
cet-13799	113	26	boodhoo	boodhoo	PROPN
cet-13799	113	27	and	and	CCONJ
cet-13799	113	28	a.	a.	NOUN
cet-13799	113	29	harvey	harvey	PROPN
cet-13799	113	30	,	,	PUNCT
cet-13799	113	31	(	(	PUNCT
cet-13799	113	32	eds	ed	NOUN
cet-13799	113	33	.	.	PUNCT
cet-13799	113	34	)	)	PUNCT
cet-13799	113	35	,	,	PUNCT
cet-13799	113	36	process	process	NOUN
cet-13799	113	37	intensification	intensification	NOUN
cet-13799	113	38	for	for	ADP
cet-13799	113	39	green	green	ADJ
cet-13799	113	40	chemistry	chemistry	PROPN
cet-13799	113	41	,	,	PUNCT
cet-13799	113	42	chichester	chichester	PROPN
cet-13799	113	43	,	,	PUNCT
cet-13799	113	44	uk	uk	PROPN
cet-13799	113	45	:	:	PUNCT
cet-13799	113	46	john	john	PROPN
cet-13799	113	47	wiley	wiley	PROPN
cet-13799	113	48	&	&	CCONJ
cet-13799	113	49	sons	sons	PROPN
cet-13799	113	50	,	,	PUNCT
cet-13799	113	51	ltd	ltd	PROPN
cet-13799	113	52	.	.	PROPN
cet-13799	113	53	pp.1–31	pp.1–31	PROPN
cet-13799	113	54	.	.	PUNCT
cet-13799	114	1	cataldo	cataldo	PROPN
cet-13799	114	2	a.l	a.l	PROPN
cet-13799	114	3	.	.	PROPN
cet-13799	114	4	,	,	PUNCT
cet-13799	114	5	sissolak	sissolak	PROPN
cet-13799	114	6	b.	b.	PROPN
cet-13799	114	7	,	,	PUNCT
cet-13799	114	8	metzger	metzger	PROPN
cet-13799	114	9	k.	k.	PROPN
cet-13799	114	10	,	,	PUNCT
cet-13799	114	11	budzinski	budzinski	PROPN
cet-13799	114	12	k.	k.	PROPN
cet-13799	114	13	,	,	PUNCT
cet-13799	114	14	shirokizawa	shirokizawa	PROPN
cet-13799	114	15	o.	o.	PROPN
cet-13799	114	16	,	,	PUNCT
cet-13799	114	17	luchner	luchner	ADJ
cet-13799	114	18	m.	m.	NOUN
cet-13799	114	19	,	,	PUNCT
cet-13799	114	20	jungbauer	jungbauer	PROPN
cet-13799	114	21	a.	a.	NOUN
cet-13799	114	22	and	and	CCONJ
cet-13799	114	23	satzer	satzer	PROPN
cet-13799	114	24	p.	p.	PROPN
cet-13799	114	25	,	,	PUNCT
cet-13799	114	26	2020	2020	NUM
cet-13799	114	27	,	,	PUNCT
cet-13799	114	28	water	water	NOUN
cet-13799	114	29	related	relate	VERB
cet-13799	114	30	impact	impact	NOUN
cet-13799	114	31	of	of	ADP
cet-13799	114	32	energy	energy	NOUN
cet-13799	114	33	:	:	PUNCT
cet-13799	114	34	cost	cost	NOUN
cet-13799	114	35	and	and	CCONJ
cet-13799	114	36	carbon	carbon	NOUN
cet-13799	114	37	footprint	footprint	NOUN
cet-13799	114	38	analysis	analysis	NOUN
cet-13799	114	39	of	of	ADP
cet-13799	114	40	water	water	NOUN
cet-13799	114	41	for	for	ADP
cet-13799	114	42	biopharmaceuticals	biopharmaceutical	NOUN
cet-13799	114	43	from	from	ADP
cet-13799	114	44	tap	tap	NOUN
cet-13799	114	45	to	to	PART
cet-13799	114	46	waste	waste	VERB
cet-13799	114	47	,	,	PUNCT
cet-13799	114	48	chemical	chemical	ADJ
cet-13799	114	49	engineering	engineering	NOUN
cet-13799	114	50	science	science	NOUN
cet-13799	114	51	:	:	PUNCT
cet-13799	114	52	x	x	X
cet-13799	114	53	,	,	PUNCT
cet-13799	114	54	8	8	NUM
cet-13799	114	55	,	,	PUNCT
cet-13799	114	56	p.100083	p.100083	NOUN
cet-13799	114	57	.	.	PUNCT
cet-13799	115	1	chen	chen	PROPN
cet-13799	115	2	y.	y.	PROPN
cet-13799	115	3	,	,	PUNCT
cet-13799	115	4	yang	yang	PROPN
cet-13799	115	5	o.	o.	PROPN
cet-13799	115	6	,	,	PUNCT
cet-13799	115	7	sampat	sampat	PROPN
cet-13799	115	8	c.	c.	PROPN
cet-13799	115	9	,	,	PUNCT
cet-13799	115	10	bhalode	bhalode	PROPN
cet-13799	115	11	p.	p.	PROPN
cet-13799	115	12	,	,	PUNCT
cet-13799	115	13	ramachandran	ramachandran	PROPN
cet-13799	115	14	r.	r.	PROPN
cet-13799	115	15	and	and	CCONJ
cet-13799	115	16	ierapetritou	ierapetritou	PROPN
cet-13799	115	17	m.	m.	NOUN
cet-13799	115	18	,	,	PUNCT
cet-13799	115	19	2020	2020	NUM
cet-13799	115	20	,	,	PUNCT
cet-13799	115	21	digital	digital	ADJ
cet-13799	115	22	twins	twin	NOUN
cet-13799	115	23	in	in	ADP
cet-13799	115	24	pharmaceutical	pharmaceutical	NOUN
cet-13799	115	25	and	and	CCONJ
cet-13799	115	26	biopharmaceutical	biopharmaceutical	NOUN
cet-13799	115	27	manufacturing	manufacturing	NOUN
cet-13799	115	28	:	:	PUNCT
cet-13799	115	29	a	a	DET
cet-13799	115	30	literature	literature	PROPN
cet-13799	115	31	review	review	NOUN
cet-13799	115	32	,	,	PUNCT
cet-13799	115	33	processes	process	NOUN
cet-13799	115	34	,	,	PUNCT
cet-13799	115	35	8(9	8(9	NUM
cet-13799	115	36	)	)	PUNCT
cet-13799	115	37	,	,	PUNCT
cet-13799	115	38	p.1088	p.1088	ADP
cet-13799	115	39	.	.	PUNCT
cet-13799	116	1	destro	destro	PROPN
cet-13799	116	2	f.	f.	PROPN
cet-13799	116	3	and	and	CCONJ
cet-13799	116	4	barolo	barolo	ADJ
cet-13799	116	5	m.	m.	NOUN
cet-13799	116	6	,	,	PUNCT
cet-13799	116	7	2022	2022	NUM
cet-13799	116	8	,	,	PUNCT
cet-13799	116	9	a	a	DET
cet-13799	116	10	review	review	NOUN
cet-13799	116	11	on	on	ADP
cet-13799	116	12	the	the	DET
cet-13799	116	13	modernization	modernization	NOUN
cet-13799	116	14	of	of	ADP
cet-13799	116	15	pharmaceutical	pharmaceutical	NOUN
cet-13799	116	16	development	development	NOUN
cet-13799	116	17	and	and	CCONJ
cet-13799	116	18	manufacturing	manufacturing	NOUN
cet-13799	116	19	–	–	PUNCT
cet-13799	116	20	trends	trend	NOUN
cet-13799	116	21	,	,	PUNCT
cet-13799	116	22	perspectives	perspective	NOUN
cet-13799	116	23	,	,	PUNCT
cet-13799	116	24	and	and	CCONJ
cet-13799	116	25	the	the	DET
cet-13799	116	26	role	role	NOUN
cet-13799	116	27	of	of	ADP
cet-13799	116	28	mathematical	mathematical	ADJ
cet-13799	116	29	modeling	modeling	NOUN
cet-13799	116	30	,	,	PUNCT
cet-13799	116	31	international	international	ADJ
cet-13799	116	32	journal	journal	NOUN
cet-13799	116	33	of	of	ADP
cet-13799	116	34	pharmaceutics	pharmaceutic	NOUN
cet-13799	116	35	,	,	PUNCT
cet-13799	116	36	620	620	NUM
cet-13799	116	37	,	,	PUNCT
cet-13799	116	38	p.121715	p.121715	NOUN
cet-13799	116	39	.	.	PROPN
cet-13799	117	1	365	365	NUM
cet-13799	117	2	fung	fung	PROPN
cet-13799	117	3	shek	shek	PROPN
cet-13799	117	4	c.	c.	PROPN
cet-13799	117	5	and	and	CCONJ
cet-13799	117	6	betenbaugh	betenbaugh	ADJ
cet-13799	117	7	m.	m.	NOUN
cet-13799	117	8	,	,	PUNCT
cet-13799	117	9	2021	2021	NUM
cet-13799	117	10	,	,	PUNCT
cet-13799	117	11	taking	take	VERB
cet-13799	117	12	the	the	DET
cet-13799	117	13	pulse	pulse	NOUN
cet-13799	117	14	of	of	ADP
cet-13799	117	15	bioprocesses	bioprocesse	NOUN
cet-13799	117	16	:	:	PUNCT
cet-13799	117	17	at	at	ADP
cet-13799	117	18	-	-	PUNCT
cet-13799	117	19	line	line	NOUN
cet-13799	117	20	and	and	CCONJ
cet-13799	117	21	in	in	ADP
cet-13799	117	22	-	-	PUNCT
cet-13799	117	23	line	line	NOUN
cet-13799	117	24	monitoring	monitoring	NOUN
cet-13799	117	25	of	of	ADP
cet-13799	117	26	mammalian	mammalian	ADJ
cet-13799	117	27	cell	cell	NOUN
cet-13799	117	28	cultures	culture	NOUN
cet-13799	117	29	,	,	PUNCT
cet-13799	117	30	current	current	ADJ
cet-13799	117	31	opinion	opinion	NOUN
cet-13799	117	32	in	in	ADP
cet-13799	117	33	biotechnology	biotechnology	NOUN
cet-13799	117	34	,	,	PUNCT
cet-13799	117	35	71	71	NUM
cet-13799	117	36	,	,	PUNCT
cet-13799	117	37	pp.191–197	pp.191–197	PROPN
cet-13799	117	38	.	.	PUNCT
cet-13799	117	39	gerzon	gerzon	PROPN
cet-13799	117	40	,	,	PUNCT
cet-13799	117	41	g.	g.	PROPN
cet-13799	117	42	,	,	PUNCT
cet-13799	117	43	sheng	sheng	PROPN
cet-13799	117	44	,	,	PUNCT
cet-13799	117	45	y.	y.	PROPN
cet-13799	117	46	and	and	CCONJ
cet-13799	117	47	kirkitadze	kirkitadze	PROPN
cet-13799	117	48	,	,	PUNCT
cet-13799	117	49	m.	m.	NOUN
cet-13799	117	50	,	,	PUNCT
cet-13799	117	51	2022	2022	NUM
cet-13799	117	52	,	,	PUNCT
cet-13799	117	53	process	process	NOUN
cet-13799	117	54	analytical	analytical	ADJ
cet-13799	117	55	technologies	technology	NOUN
cet-13799	117	56	–	–	PUNCT
cet-13799	117	57	advances	advance	NOUN
cet-13799	117	58	in	in	ADP
cet-13799	117	59	bioprocess	bioprocess	NOUN
cet-13799	117	60	integration	integration	NOUN
cet-13799	117	61	and	and	CCONJ
cet-13799	117	62	future	future	ADJ
cet-13799	117	63	perspectives	perspective	NOUN
cet-13799	117	64	,	,	PUNCT
cet-13799	117	65	journal	journal	NOUN
cet-13799	117	66	of	of	ADP
cet-13799	117	67	pharmaceutical	pharmaceutical	NOUN
cet-13799	117	68	and	and	CCONJ
cet-13799	117	69	biomedical	biomedical	ADJ
cet-13799	117	70	analysis	analysis	NOUN
cet-13799	117	71	,	,	PUNCT
cet-13799	117	72	207	207	NUM
cet-13799	117	73	,	,	PUNCT
cet-13799	117	74	p.114379	p.114379	PROPN
cet-13799	117	75	.	.	PUNCT
cet-13799	117	76	golabgir	golabgir	PROPN
cet-13799	117	77	a.	a.	PROPN
cet-13799	117	78	,	,	PUNCT
cet-13799	117	79	hoch	hoch	NOUN
cet-13799	117	80	t.	t.	PROPN
cet-13799	117	81	,	,	PUNCT
cet-13799	117	82	zhariy	zhariy	PROPN
cet-13799	117	83	m.	m.	NOUN
cet-13799	117	84	and	and	CCONJ
cet-13799	117	85	herwig	herwig	PROPN
cet-13799	117	86	c.	c.	PROPN
cet-13799	117	87	,	,	PUNCT
cet-13799	117	88	2015	2015	NUM
cet-13799	117	89	,	,	PUNCT
cet-13799	117	90	observability	observability	NOUN
cet-13799	117	91	analysis	analysis	NOUN
cet-13799	117	92	of	of	ADP
cet-13799	117	93	biochemical	biochemical	ADJ
cet-13799	117	94	process	process	NOUN
cet-13799	117	95	models	model	NOUN
cet-13799	117	96	as	as	ADP
cet-13799	117	97	a	a	DET
cet-13799	117	98	valuable	valuable	ADJ
cet-13799	117	99	tool	tool	NOUN
cet-13799	117	100	for	for	ADP
cet-13799	117	101	the	the	DET
cet-13799	117	102	development	development	NOUN
cet-13799	117	103	of	of	ADP
cet-13799	117	104	mechanistic	mechanistic	ADJ
cet-13799	117	105	soft	soft	ADJ
cet-13799	117	106	sensors	sensor	NOUN
cet-13799	117	107	,	,	PUNCT
cet-13799	117	108	biotechnology	biotechnology	NOUN
cet-13799	117	109	progress	progress	NOUN
cet-13799	117	110	,	,	PUNCT
cet-13799	117	111	31(6	31(6	NUM
cet-13799	117	112	)	)	PUNCT
cet-13799	117	113	,	,	PUNCT
cet-13799	117	114	pp.1703	pp.1703	PROPN
cet-13799	117	115	–	–	PUNCT
cet-13799	117	116	1715	1715	NUM
cet-13799	117	117	.	.	PUNCT
cet-13799	118	1	hong	hong	PROPN
cet-13799	118	2	m.s	m.s	PROPN
cet-13799	118	3	.	.	PROPN
cet-13799	118	4	,	,	PUNCT
cet-13799	118	5	severson	severson	PROPN
cet-13799	118	6	k.a	k.a	PROPN
cet-13799	118	7	.	.	PROPN
cet-13799	118	8	,	,	PUNCT
cet-13799	118	9	jiang	jiang	PROPN
cet-13799	118	10	m.	m.	PROPN
cet-13799	118	11	,	,	PUNCT
cet-13799	118	12	lu	lu	PROPN
cet-13799	118	13	a.e	a.e	PROPN
cet-13799	118	14	.	.	PROPN
cet-13799	118	15	,	,	PUNCT
cet-13799	118	16	love	love	PROPN
cet-13799	118	17	j.c	j.c	PROPN
cet-13799	118	18	.	.	PROPN
cet-13799	118	19	and	and	CCONJ
cet-13799	118	20	braatz	braatz	PROPN
cet-13799	118	21	r.d	r.d	PROPN
cet-13799	118	22	.	.	PROPN
cet-13799	118	23	,	,	PUNCT
cet-13799	118	24	2018	2018	NUM
cet-13799	118	25	,	,	PUNCT
cet-13799	118	26	challenges	challenge	NOUN
cet-13799	118	27	and	and	CCONJ
cet-13799	118	28	opportunities	opportunity	NOUN
cet-13799	118	29	in	in	ADP
cet-13799	118	30	biopharmaceutical	biopharmaceutical	ADJ
cet-13799	118	31	manufacturing	manufacturing	NOUN
cet-13799	118	32	control	control	NOUN
cet-13799	118	33	,	,	PUNCT
cet-13799	118	34	computers	computer	NOUN
cet-13799	118	35	&	&	CCONJ
cet-13799	118	36	chemical	chemical	PROPN
cet-13799	118	37	engineering	engineering	PROPN
cet-13799	118	38	,	,	PUNCT
cet-13799	118	39	110	110	NUM
cet-13799	118	40	,	,	PUNCT
cet-13799	118	41	pp.106–114	pp.106–114	PROPN
cet-13799	118	42	.	.	PUNCT
cet-13799	119	1	jimenez	jimenez	PROPN
cet-13799	119	2	-	-	PUNCT
cet-13799	119	3	gonzalez	gonzalez	PROPN
cet-13799	119	4	c.	c.	PROPN
cet-13799	119	5	“	"	PUNCT
cet-13799	119	6	conchita	conchita	PROPN
cet-13799	119	7	”	"	PUNCT
cet-13799	119	8	and	and	CCONJ
cet-13799	119	9	lund	lund	PROPN
cet-13799	119	10	c.	c.	PROPN
cet-13799	119	11	,	,	PUNCT
cet-13799	119	12	2022	2022	NUM
cet-13799	119	13	,	,	PUNCT
cet-13799	119	14	green	green	ADJ
cet-13799	119	15	metrics	metric	NOUN
cet-13799	119	16	in	in	ADP
cet-13799	119	17	pharmaceutical	pharmaceutical	ADJ
cet-13799	119	18	development	development	NOUN
cet-13799	119	19	,	,	PUNCT
cet-13799	119	20	current	current	ADJ
cet-13799	119	21	opinion	opinion	NOUN
cet-13799	119	22	in	in	ADP
cet-13799	119	23	green	green	ADJ
cet-13799	119	24	and	and	CCONJ
cet-13799	119	25	sustainable	sustainable	ADJ
cet-13799	119	26	chemistry	chemistry	NOUN
cet-13799	119	27	,	,	PUNCT
cet-13799	119	28	33	33	NUM
cet-13799	119	29	,	,	PUNCT
cet-13799	119	30	p.100564	p.100564	ADJ
cet-13799	119	31	.	.	PUNCT
cet-13799	120	1	kamble	kamble	PROPN
cet-13799	120	2	s.s	s.s	PROPN
cet-13799	120	3	.	.	PROPN
cet-13799	120	4	,	,	PUNCT
cet-13799	120	5	gunasekaran	gunasekaran	NOUN
cet-13799	120	6	a.	a.	NOUN
cet-13799	120	7	and	and	CCONJ
cet-13799	120	8	gawankar	gawankar	PROPN
cet-13799	120	9	s.a	s.a	PROPN
cet-13799	120	10	.	.	PROPN
cet-13799	120	11	,	,	PUNCT
cet-13799	120	12	2018	2018	NUM
cet-13799	120	13	,	,	PUNCT
cet-13799	120	14	sustainable	sustainable	ADJ
cet-13799	120	15	industry	industry	NOUN
cet-13799	120	16	4.0	4.0	NUM
cet-13799	120	17	framework	framework	NOUN
cet-13799	120	18	:	:	PUNCT
cet-13799	120	19	a	a	DET
cet-13799	120	20	systematic	systematic	ADJ
cet-13799	120	21	literature	literature	NOUN
cet-13799	120	22	review	review	NOUN
cet-13799	120	23	identifying	identify	VERB
cet-13799	120	24	the	the	DET
cet-13799	120	25	current	current	ADJ
cet-13799	120	26	trends	trend	NOUN
cet-13799	120	27	and	and	CCONJ
cet-13799	120	28	future	future	ADJ
cet-13799	120	29	perspectives	perspective	NOUN
cet-13799	120	30	,	,	PUNCT
cet-13799	120	31	process	process	NOUN
cet-13799	120	32	safety	safety	NOUN
cet-13799	120	33	and	and	CCONJ
cet-13799	120	34	environmental	environmental	ADJ
cet-13799	120	35	protection	protection	NOUN
cet-13799	120	36	,	,	PUNCT
cet-13799	120	37	117	117	NUM
cet-13799	120	38	,	,	PUNCT
cet-13799	120	39	pp.408–425	pp.408–425	NOUN
cet-13799	120	40	.	.	PUNCT
cet-13799	121	1	kaur	kaur	PROPN
cet-13799	121	2	a.	a.	PROPN
cet-13799	121	3	,	,	PUNCT
cet-13799	121	4	singh	singh	PROPN
cet-13799	121	5	v.p	v.p	PROPN
cet-13799	121	6	.	.	PROPN
cet-13799	121	7	and	and	CCONJ
cet-13799	121	8	singh	singh	PROPN
cet-13799	121	9	gill	gill	PROPN
cet-13799	121	10	s.	s.	PROPN
cet-13799	121	11	,	,	PUNCT
cet-13799	121	12	2018	2018	NUM
cet-13799	121	13	,	,	PUNCT
cet-13799	121	14	the	the	DET
cet-13799	121	15	future	future	NOUN
cet-13799	121	16	of	of	ADP
cet-13799	121	17	cloud	cloud	NOUN
cet-13799	121	18	computing	computing	NOUN
cet-13799	121	19	:	:	PUNCT
cet-13799	121	20	opportunities	opportunity	NOUN
cet-13799	121	21	,	,	PUNCT
cet-13799	121	22	challenges	challenge	NOUN
cet-13799	121	23	and	and	CCONJ
cet-13799	121	24	research	research	NOUN
cet-13799	121	25	trends	trend	NOUN
cet-13799	121	26	,	,	PUNCT
cet-13799	121	27	in	in	ADP
cet-13799	121	28	:	:	PUNCT
cet-13799	121	29	2018	2018	NUM
cet-13799	121	30	2nd	2nd	ADJ
cet-13799	121	31	international	international	ADJ
cet-13799	121	32	conference	conference	NOUN
cet-13799	121	33	on	on	ADP
cet-13799	121	34	2018	2018	NUM
cet-13799	121	35	2nd	2nd	ADJ
cet-13799	121	36	international	international	ADJ
cet-13799	121	37	conference	conference	NOUN
cet-13799	121	38	on	on	ADP
cet-13799	121	39	i	i	PROPN
cet-13799	121	40	-	-	PUNCT
cet-13799	121	41	smac	smac	PROPN
cet-13799	121	42	(	(	PUNCT
cet-13799	121	43	iot	iot	PROPN
cet-13799	121	44	in	in	ADP
cet-13799	121	45	social	social	ADJ
cet-13799	121	46	,	,	PUNCT
cet-13799	121	47	mobile	mobile	ADJ
cet-13799	121	48	,	,	PUNCT
cet-13799	121	49	analytics	analytic	NOUN
cet-13799	121	50	and	and	CCONJ
cet-13799	121	51	cloud	cloud	NOUN
cet-13799	121	52	)	)	PUNCT
cet-13799	121	53	(	(	PUNCT
cet-13799	121	54	i	i	NOUN
cet-13799	121	55	-	-	PUNCT
cet-13799	121	56	smac)i	smac)i	NOUN
cet-13799	121	57	-	-	PUNCT
cet-13799	121	58	smac	smac	PROPN
cet-13799	121	59	(	(	PUNCT
cet-13799	121	60	iot	iot	PROPN
cet-13799	121	61	in	in	ADP
cet-13799	121	62	social	social	ADJ
cet-13799	121	63	,	,	PUNCT
cet-13799	121	64	mobile	mobile	ADJ
cet-13799	121	65	,	,	PUNCT
cet-13799	121	66	analytics	analytic	NOUN
cet-13799	121	67	and	and	CCONJ
cet-13799	121	68	cloud	cloud	NOUN
cet-13799	121	69	)	)	PUNCT
cet-13799	121	70	(	(	PUNCT
cet-13799	121	71	ismac	ismac	NOUN
cet-13799	121	72	)	)	PUNCT
cet-13799	121	73	,	,	PUNCT
cet-13799	121	74	2018	2018	NUM
cet-13799	121	75	2nd	2nd	ADJ
cet-13799	121	76	international	international	ADJ
cet-13799	121	77	conference	conference	NOUN
cet-13799	121	78	on	on	ADP
cet-13799	121	79	2018	2018	NUM
cet-13799	121	80	2nd	2nd	ADJ
cet-13799	121	81	international	international	ADJ
cet-13799	121	82	conference	conference	NOUN
cet-13799	121	83	on	on	ADP
cet-13799	121	84	i	i	PROPN
cet-13799	121	85	-	-	PUNCT
cet-13799	121	86	smac	smac	PROPN
cet-13799	121	87	(	(	PUNCT
cet-13799	121	88	iot	iot	PROPN
cet-13799	121	89	in	in	ADP
cet-13799	121	90	social	social	ADJ
cet-13799	121	91	,	,	PUNCT
cet-13799	121	92	mobile	mobile	ADJ
cet-13799	121	93	,	,	PUNCT
cet-13799	121	94	analytics	analytic	NOUN
cet-13799	121	95	and	and	CCONJ
cet-13799	121	96	cloud	cloud	NOUN
cet-13799	121	97	)	)	PUNCT
cet-13799	121	98	(	(	PUNCT
cet-13799	121	99	i	i	NOUN
cet-13799	121	100	-	-	PUNCT
cet-13799	121	101	smac)i	smac)i	NOUN
cet-13799	121	102	-	-	PUNCT
cet-13799	121	103	smac	smac	PROPN
cet-13799	121	104	(	(	PUNCT
cet-13799	121	105	iot	iot	PROPN
cet-13799	121	106	in	in	ADP
cet-13799	121	107	social	social	ADJ
cet-13799	121	108	,	,	PUNCT
cet-13799	121	109	mobile	mobile	ADJ
cet-13799	121	110	,	,	PUNCT
cet-13799	121	111	analytics	analytic	NOUN
cet-13799	121	112	and	and	CCONJ
cet-13799	121	113	cloud	cloud	NOUN
cet-13799	121	114	)	)	PUNCT
cet-13799	121	115	(	(	PUNCT
cet-13799	121	116	i	i	PROPN
cet-13799	121	117	-	-	PUNCT
cet-13799	121	118	smac	smac	PROPN
cet-13799	121	119	)	)	PUNCT
cet-13799	121	120	,	,	PUNCT
cet-13799	121	121	pp.213–219	pp.213–219	PROPN
cet-13799	121	122	.	.	PUNCT
cet-13799	122	1	kempf	kempf	PROPN
cet-13799	122	2	j.	j.	PROPN
cet-13799	122	3	,	,	PUNCT
cet-13799	122	4	2018	2018	NUM
cet-13799	122	5	,	,	PUNCT
cet-13799	122	6	continuous	continuous	ADJ
cet-13799	122	7	online	online	ADJ
cet-13799	122	8	measurement	measurement	NOUN
cet-13799	122	9	of	of	ADP
cet-13799	122	10	viable	viable	ADJ
cet-13799	122	11	cell	cell	NOUN
cet-13799	122	12	density	density	NOUN
cet-13799	122	13	for	for	ADP
cet-13799	122	14	improved	improved	ADJ
cet-13799	122	15	process	process	NOUN
cet-13799	122	16	insight	insight	NOUN
cet-13799	122	17	.	.	PUNCT
cet-13799	123	1	<	<	AUX
cet-13799	123	2	https://www.process-worldwide.com/continuous-online-measurement-of-viable-cell-density-for-improvedprocess-insight-a-722766/	https://www.process-worldwide.com/continuous-online-measurement-of-viable-cell-density-for-improvedprocess-insight-a-722766/	X
cet-13799	123	3	>	>	X
cet-13799	123	4	accessed	access	VERB
cet-13799	123	5	10.03.2023	10.03.2023	PROPN
cet-13799	123	6	.	.	PUNCT
cet-13799	124	1	kroll	kroll	PROPN
cet-13799	124	2	p.	p.	PROPN
cet-13799	124	3	,	,	PUNCT
cet-13799	124	4	hofer	hofer	PROPN
cet-13799	124	5	a.	a.	PROPN
cet-13799	124	6	,	,	PUNCT
cet-13799	124	7	ulonska	ulonska	PROPN
cet-13799	124	8	s.	s.	PROPN
cet-13799	124	9	,	,	PUNCT
cet-13799	124	10	kager	kager	PROPN
cet-13799	124	11	j.	j.	PROPN
cet-13799	124	12	and	and	CCONJ
cet-13799	124	13	herwig	herwig	PROPN
cet-13799	124	14	c.	c.	PROPN
cet-13799	124	15	,	,	PUNCT
cet-13799	124	16	2017	2017	NUM
cet-13799	124	17	,	,	PUNCT
cet-13799	124	18	model	model	NOUN
cet-13799	124	19	-	-	PUNCT
cet-13799	124	20	based	base	VERB
cet-13799	124	21	methods	method	NOUN
cet-13799	124	22	in	in	ADP
cet-13799	124	23	the	the	DET
cet-13799	124	24	biopharmaceutical	biopharmaceutical	ADJ
cet-13799	124	25	process	process	NOUN
cet-13799	124	26	lifecycle	lifecycle	NOUN
cet-13799	124	27	,	,	PUNCT
cet-13799	124	28	pharmaceutical	pharmaceutical	ADJ
cet-13799	124	29	research	research	NOUN
cet-13799	124	30	,	,	PUNCT
cet-13799	124	31	34(12	34(12	NUM
cet-13799	124	32	)	)	PUNCT
cet-13799	124	33	,	,	PUNCT
cet-13799	124	34	pp.2596–2613	pp.2596–2613	PROPN
cet-13799	124	35	.	.	PUNCT
cet-13799	124	36	luttmann	luttmann	PROPN
cet-13799	124	37	r.	r.	PROPN
cet-13799	124	38	,	,	PUNCT
cet-13799	124	39	bracewell	bracewell	PROPN
cet-13799	124	40	d.g	d.g	PROPN
cet-13799	124	41	.	.	PROPN
cet-13799	124	42	,	,	PUNCT
cet-13799	124	43	cornelissen	cornelissen	PROPN
cet-13799	124	44	g.	g.	PROPN
cet-13799	124	45	,	,	PUNCT
cet-13799	124	46	gernaey	gernaey	PROPN
cet-13799	124	47	k.v	k.v	PROPN
cet-13799	124	48	.	.	PROPN
cet-13799	124	49	,	,	PUNCT
cet-13799	124	50	glassey	glassey	NOUN
cet-13799	124	51	j.	j.	PROPN
cet-13799	124	52	,	,	PUNCT
cet-13799	124	53	hass	hass	VERB
cet-13799	124	54	v.c	v.c	PROPN
cet-13799	124	55	.	.	PROPN
cet-13799	124	56	,	,	PUNCT
cet-13799	124	57	kaiser	kaiser	PROPN
cet-13799	124	58	c.	c.	PROPN
cet-13799	124	59	,	,	PUNCT
cet-13799	124	60	preusse	preusse	PROPN
cet-13799	124	61	c.	c.	PROPN
cet-13799	124	62	,	,	PUNCT
cet-13799	124	63	striedner	striedner	NOUN
cet-13799	124	64	g.	g.	PROPN
cet-13799	124	65	and	and	CCONJ
cet-13799	124	66	mandenius	mandenius	ADJ
cet-13799	124	67	c.-f	c.-f	NOUN
cet-13799	124	68	.	.	PUNCT
cet-13799	124	69	,	,	PUNCT
cet-13799	124	70	2012	2012	NUM
cet-13799	124	71	,	,	PUNCT
cet-13799	124	72	soft	soft	ADJ
cet-13799	124	73	sensors	sensor	NOUN
cet-13799	124	74	in	in	ADP
cet-13799	124	75	bioprocessing	bioprocesse	VERB
cet-13799	124	76	:	:	PUNCT
cet-13799	124	77	a	a	DET
cet-13799	124	78	status	status	NOUN
cet-13799	124	79	report	report	NOUN
cet-13799	124	80	and	and	CCONJ
cet-13799	124	81	recommendations	recommendation	NOUN
cet-13799	124	82	,	,	PUNCT
cet-13799	124	83	biotechnology	biotechnology	NOUN
cet-13799	124	84	journal	journal	NOUN
cet-13799	124	85	,	,	PUNCT
cet-13799	124	86	7(8	7(8	NUM
cet-13799	124	87	)	)	PUNCT
cet-13799	124	88	,	,	PUNCT
cet-13799	124	89	pp.1040–1048	pp.1040–1048	PROPN
cet-13799	124	90	.	.	PUNCT
cet-13799	125	1	müller	müller	PROPN
cet-13799	125	2	d.f	d.f	PROPN
cet-13799	125	3	.	.	PROPN
cet-13799	125	4	,	,	PUNCT
cet-13799	125	5	wibbing	wibbe	VERB
cet-13799	125	6	d.	d.	PROPN
cet-13799	125	7	,	,	PUNCT
cet-13799	125	8	herwig	herwig	PROPN
cet-13799	125	9	c.	c.	PROPN
cet-13799	125	10	and	and	CCONJ
cet-13799	125	11	kager	kager	PROPN
cet-13799	125	12	j.	j.	PROPN
cet-13799	125	13	,	,	PUNCT
cet-13799	125	14	2023	2023	NUM
cet-13799	125	15	,	,	PUNCT
cet-13799	125	16	simultaneous	simultaneous	ADJ
cet-13799	125	17	real	real	ADJ
cet-13799	125	18	-	-	PUNCT
cet-13799	125	19	time	time	NOUN
cet-13799	125	20	estimation	estimation	NOUN
cet-13799	125	21	of	of	ADP
cet-13799	125	22	maximum	maximum	ADJ
cet-13799	125	23	substrate	substrate	NOUN
cet-13799	125	24	uptake	uptake	ADJ
cet-13799	125	25	capacity	capacity	NOUN
cet-13799	125	26	and	and	CCONJ
cet-13799	125	27	yield	yield	VERB
cet-13799	125	28	coefficient	coefficient	NOUN
cet-13799	125	29	in	in	ADP
cet-13799	125	30	induced	induced	ADJ
cet-13799	125	31	microbial	microbial	ADJ
cet-13799	125	32	cultures	culture	NOUN
cet-13799	125	33	,	,	PUNCT
cet-13799	125	34	computers	computer	NOUN
cet-13799	125	35	&	&	CCONJ
cet-13799	125	36	chemical	chemical	PROPN
cet-13799	125	37	engineering	engineering	PROPN
cet-13799	125	38	,	,	PUNCT
cet-13799	125	39	173	173	NUM
cet-13799	125	40	,	,	PUNCT
cet-13799	125	41	p.108203	p.108203	AUX
cet-13799	125	42	.	.	PUNCT
cet-13799	126	1	sacher	sacher	PROPN
cet-13799	126	2	s.	s.	PROPN
cet-13799	126	3	,	,	PUNCT
cet-13799	126	4	poms	poms	PROPN
cet-13799	126	5	j.	j.	PROPN
cet-13799	126	6	,	,	PUNCT
cet-13799	126	7	rehrl	rehrl	PROPN
cet-13799	126	8	j.	j.	PROPN
cet-13799	126	9	and	and	CCONJ
cet-13799	126	10	khinast	khinast	VERB
cet-13799	126	11	j.g	j.g	PROPN
cet-13799	126	12	.	.	PROPN
cet-13799	126	13	,	,	PUNCT
cet-13799	126	14	2022	2022	NUM
cet-13799	126	15	,	,	PUNCT
cet-13799	126	16	pat	pat	NOUN
cet-13799	126	17	implementation	implementation	NOUN
cet-13799	126	18	for	for	ADP
cet-13799	126	19	advanced	advanced	ADJ
cet-13799	126	20	process	process	NOUN
cet-13799	126	21	control	control	NOUN
cet-13799	126	22	in	in	ADP
cet-13799	126	23	solid	solid	ADJ
cet-13799	126	24	dosage	dosage	NOUN
cet-13799	126	25	manufacturing	manufacturing	NOUN
cet-13799	126	26	–	–	PUNCT
cet-13799	126	27	a	a	DET
cet-13799	126	28	practical	practical	ADJ
cet-13799	126	29	guide	guide	NOUN
cet-13799	126	30	,	,	PUNCT
cet-13799	126	31	international	international	ADJ
cet-13799	126	32	journal	journal	NOUN
cet-13799	126	33	of	of	ADP
cet-13799	126	34	pharmaceutics	pharmaceutic	NOUN
cet-13799	126	35	,	,	PUNCT
cet-13799	126	36	613	613	NUM
cet-13799	126	37	,	,	PUNCT
cet-13799	126	38	p.121408	p.121408	PROPN
cet-13799	126	39	.	.	PUNCT
cet-13799	127	1	sagmeister	sagmeister	PROPN
cet-13799	127	2	p.	p.	PROPN
cet-13799	127	3	,	,	PUNCT
cet-13799	127	4	wechselberger	wechselberger	NOUN
cet-13799	127	5	p.	p.	NOUN
cet-13799	127	6	,	,	PUNCT
cet-13799	127	7	jazini	jazini	PROPN
cet-13799	127	8	m.	m.	NOUN
cet-13799	127	9	,	,	PUNCT
cet-13799	127	10	meitz	meitz	PROPN
cet-13799	127	11	a.	a.	PROPN
cet-13799	127	12	,	,	PUNCT
cet-13799	127	13	langemann	langemann	PROPN
cet-13799	127	14	t.	t.	PROPN
cet-13799	127	15	and	and	CCONJ
cet-13799	127	16	herwig	herwig	PROPN
cet-13799	127	17	c.	c.	PROPN
cet-13799	127	18	,	,	PUNCT
cet-13799	127	19	2013	2013	NUM
cet-13799	127	20	,	,	PUNCT
cet-13799	127	21	soft	soft	ADJ
cet-13799	127	22	sensor	sensor	NOUN
cet-13799	127	23	assisted	assist	VERB
cet-13799	127	24	dynamic	dynamic	ADJ
cet-13799	127	25	bioprocess	bioprocess	NOUN
cet-13799	127	26	control	control	NOUN
cet-13799	127	27	:	:	PUNCT
cet-13799	127	28	efficient	efficient	ADJ
cet-13799	127	29	tools	tool	NOUN
cet-13799	127	30	for	for	ADP
cet-13799	127	31	bioprocess	bioprocess	NOUN
cet-13799	127	32	development	development	NOUN
cet-13799	127	33	,	,	PUNCT
cet-13799	127	34	chemical	chemical	NOUN
cet-13799	127	35	engineering	engineering	NOUN
cet-13799	127	36	science	science	NOUN
cet-13799	127	37	,	,	PUNCT
cet-13799	127	38	96	96	NUM
cet-13799	127	39	,	,	PUNCT
cet-13799	127	40	pp.190–198	pp.190–198	ADJ
cet-13799	127	41	.	.	PUNCT
cet-13799	128	1	sommeregger	sommeregger	PROPN
cet-13799	128	2	w.	w.	PROPN
cet-13799	128	3	,	,	PUNCT
cet-13799	128	4	sissolak	sissolak	PROPN
cet-13799	128	5	b.	b.	PROPN
cet-13799	128	6	,	,	PUNCT
cet-13799	128	7	kandra	kandra	PROPN
cet-13799	128	8	k.	k.	PROPN
cet-13799	128	9	,	,	PUNCT
cet-13799	128	10	von	von	PROPN
cet-13799	128	11	stosch	stosch	PROPN
cet-13799	128	12	m.	m.	NOUN
cet-13799	128	13	,	,	PUNCT
cet-13799	128	14	mayer	mayer	PROPN
cet-13799	128	15	m.	m.	NOUN
cet-13799	128	16	and	and	CCONJ
cet-13799	128	17	striedner	striedner	PROPN
cet-13799	128	18	g.	g.	PROPN
cet-13799	128	19	,	,	PUNCT
cet-13799	128	20	2017	2017	NUM
cet-13799	128	21	,	,	PUNCT
cet-13799	128	22	quality	quality	NOUN
cet-13799	128	23	by	by	ADP
cet-13799	128	24	control	control	NOUN
cet-13799	128	25	:	:	PUNCT
cet-13799	128	26	towards	towards	ADP
cet-13799	128	27	model	model	NOUN
cet-13799	128	28	predictive	predictive	ADJ
cet-13799	128	29	control	control	NOUN
cet-13799	128	30	of	of	ADP
cet-13799	128	31	mammalian	mammalian	ADJ
cet-13799	128	32	cell	cell	NOUN
cet-13799	128	33	culture	culture	NOUN
cet-13799	128	34	bioprocesses	bioprocesse	NOUN
cet-13799	128	35	,	,	PUNCT
cet-13799	128	36	biotechnology	biotechnology	NOUN
cet-13799	128	37	journal	journal	NOUN
cet-13799	128	38	,	,	PUNCT
cet-13799	128	39	12(7	12(7	NUM
cet-13799	128	40	)	)	PUNCT
cet-13799	128	41	,	,	PUNCT
cet-13799	128	42	p.1600546	p.1600546	PROPN
cet-13799	128	43	.	.	PUNCT
cet-13799	129	1	steinwandter	steinwandter	PROPN
cet-13799	129	2	v.	v.	PROPN
cet-13799	129	3	,	,	PUNCT
cet-13799	129	4	borchert	borchert	PROPN
cet-13799	129	5	d.	d.	PROPN
cet-13799	129	6	and	and	CCONJ
cet-13799	129	7	herwig	herwig	PROPN
cet-13799	129	8	c.	c.	PROPN
cet-13799	129	9	,	,	PUNCT
cet-13799	129	10	2019	2019	NUM
cet-13799	129	11	,	,	PUNCT
cet-13799	129	12	data	datum	NOUN
cet-13799	129	13	science	science	NOUN
cet-13799	129	14	tools	tool	NOUN
cet-13799	129	15	and	and	CCONJ
cet-13799	129	16	applications	application	NOUN
cet-13799	129	17	on	on	ADP
cet-13799	129	18	the	the	DET
cet-13799	129	19	way	way	NOUN
cet-13799	129	20	to	to	ADP
cet-13799	129	21	pharma	pharma	PROPN
cet-13799	129	22	4.0	4.0	NUM
cet-13799	129	23	,	,	PUNCT
cet-13799	129	24	drug	drug	NOUN
cet-13799	129	25	discovery	discovery	NOUN
cet-13799	129	26	today	today	NOUN
cet-13799	129	27	,	,	PUNCT
cet-13799	129	28	24(9	24(9	NUM
cet-13799	129	29	)	)	PUNCT
cet-13799	129	30	,	,	PUNCT
cet-13799	129	31	pp.1795–1805	pp.1795–1805	PROPN
cet-13799	129	32	.	.	PUNCT
cet-13799	130	1	366	366	NUM
cet-13799	130	2	67imran.pdf	67imran.pdf	NUM
cet-13799	130	3	a	a	DET
cet-13799	130	4	perspective	perspective	NOUN
cet-13799	130	5	on	on	ADP
cet-13799	130	6	the	the	DET
cet-13799	130	7	role	role	NOUN
cet-13799	130	8	of	of	ADP
cet-13799	130	9	digitalization	digitalization	NOUN
cet-13799	130	10	enablers	enabler	NOUN
cet-13799	130	11	in	in	ADP
cet-13799	130	12	sustainable	sustainable	ADJ
cet-13799	130	13	pharmaceutical	pharmaceutical	NOUN
cet-13799	130	14	manufacturing	manufacturing	NOUN