id	sid	tid	token	lemma	pos
cet-15443	1	1	doi	doi	NOUN
cet-15443	1	2	:	:	PUNCT
cet-15443	1	3	10.3303	10.3303	NUM
cet-15443	1	4	/	/	SYM
cet-15443	1	5	cet25117193	cet25117193	ADJ
cet-15443	1	6	paper	paper	NOUN
cet-15443	1	7	received	receive	VERB
cet-15443	1	8	:	:	PUNCT
cet-15443	1	9	18	18	NUM
cet-15443	1	10	december	december	PROPN
cet-15443	1	11	2024	2024	NUM
cet-15443	1	12	;	;	PUNCT
cet-15443	1	13	revised	revise	VERB
cet-15443	1	14	:	:	PUNCT
cet-15443	1	15	22	22	NUM
cet-15443	1	16	february	february	NOUN
cet-15443	1	17	2025	2025	NUM
cet-15443	1	18	;	;	PUNCT
cet-15443	1	19	accepted	accept	VERB
cet-15443	1	20	:	:	PUNCT
cet-15443	1	21	29	29	NUM
cet-15443	1	22	april	april	PROPN
cet-15443	1	23	2025	2025	NUM
cet-15443	1	24	please	please	INTJ
cet-15443	1	25	cite	cite	VERB
cet-15443	1	26	this	this	DET
cet-15443	1	27	article	article	NOUN
cet-15443	1	28	as	as	ADP
cet-15443	1	29	:	:	PUNCT
cet-15443	1	30	traversari	traversari	PROPN
cet-15443	1	31	g.	g.	PROPN
cet-15443	1	32	,	,	PUNCT
cet-15443	1	33	locci	locci	PROPN
cet-15443	1	34	a.	a.	PROPN
cet-15443	1	35	,	,	PUNCT
cet-15443	1	36	concas	concas	PROPN
cet-15443	1	37	a.	a.	PROPN
cet-15443	1	38	,	,	PUNCT
cet-15443	1	39	lai	lai	PROPN
cet-15443	1	40	n.	n.	PROPN
cet-15443	1	41	,	,	PUNCT
cet-15443	1	42	cincotti	cincotti	PROPN
cet-15443	1	43	a.	a.	PROPN
cet-15443	1	44	,	,	PUNCT
cet-15443	1	45	cao	cao	PROPN
cet-15443	1	46	g.	g.	PROPN
cet-15443	1	47	,	,	PUNCT
cet-15443	1	48	2025	2025	NUM
cet-15443	1	49	,	,	PUNCT
cet-15443	1	50	computational	computational	ADJ
cet-15443	1	51	analysis	analysis	NOUN
cet-15443	1	52	of	of	ADP
cet-15443	1	53	the	the	DET
cet-15443	1	54	effect	effect	NOUN
cet-15443	1	55	of	of	ADP
cet-15443	1	56	inhibitor	inhibitor	NOUN
cet-15443	1	57	proteins	protein	NOUN
cet-15443	1	58	p21	p21	NOUN
cet-15443	1	59	/	/	SYM
cet-15443	1	60	p27	p27	NOUN
cet-15443	1	61	on	on	ADP
cet-15443	1	62	cell	cell	NOUN
cet-15443	1	63	cycle	cycle	NOUN
cet-15443	1	64	under	under	ADP
cet-15443	1	65	microgravity	microgravity	NOUN
cet-15443	1	66	conditions	condition	NOUN
cet-15443	1	67	,	,	PUNCT
cet-15443	1	68	chemical	chemical	ADJ
cet-15443	1	69	engineering	engineering	NOUN
cet-15443	1	70	transactions	transaction	NOUN
cet-15443	1	71	,	,	PUNCT
cet-15443	1	72	117	117	NUM
cet-15443	1	73	,	,	PUNCT
cet-15443	1	74	1153	1153	NUM
cet-15443	1	75	-	-	SYM
cet-15443	1	76	1158	1158	NUM
cet-15443	1	77	doi:10.3303	doi:10.3303	NOUN
cet-15443	1	78	/	/	SYM
cet-15443	1	79	cet25117193	cet25117193	NOUN
cet-15443	1	80	chemical	chemical	PROPN
cet-15443	1	81	engineering	engineering	NOUN
cet-15443	1	82	transactions	transaction	NOUN
cet-15443	1	83	vol	vol	NOUN
cet-15443	1	84	.	.	PROPN
cet-15443	1	85	117	117	NUM
cet-15443	1	86	,	,	PUNCT
cet-15443	1	87	2025	2025	NUM
cet-15443	1	88	a	a	DET
cet-15443	1	89	publication	publication	NOUN
cet-15443	1	90	of	of	ADP
cet-15443	1	91	the	the	DET
cet-15443	1	92	italian	italian	ADJ
cet-15443	1	93	association	association	NOUN
cet-15443	1	94	of	of	ADP
cet-15443	1	95	chemical	chemical	PROPN
cet-15443	1	96	engineering	engineering	NOUN
cet-15443	1	97	online	online	ADV
cet-15443	1	98	at	at	ADP
cet-15443	1	99	www.cetjournal.it	www.cetjournal.it	PROPN
cet-15443	1	100	guest	guest	NOUN
cet-15443	1	101	editors	editor	NOUN
cet-15443	1	102	:	:	PUNCT
cet-15443	1	103	fabrizio	fabrizio	PROPN
cet-15443	1	104	bezzo	bezzo	PROPN
cet-15443	1	105	,	,	PUNCT
cet-15443	1	106	flavio	flavio	PROPN
cet-15443	1	107	manenti	manenti	PROPN
cet-15443	1	108	,	,	PUNCT
cet-15443	1	109	gabriele	gabriele	PROPN
cet-15443	1	110	pannocchia	pannocchia	PROPN
cet-15443	1	111	,	,	PUNCT
cet-15443	1	112	almerinda	almerinda	PROPN
cet-15443	1	113	di	di	PROPN
cet-15443	1	114	benedetto	benedetto	PROPN
cet-15443	1	115	copyright	copyright	PROPN
cet-15443	2	1	©	©	PROPN
cet-15443	2	2	2025	2025	NUM
cet-15443	2	3	,	,	PUNCT
cet-15443	2	4	aidic	aidic	ADJ
cet-15443	2	5	servizi	servizi	PROPN
cet-15443	2	6	s.r.l	s.r.l	NOUN
cet-15443	2	7	.	.	PUNCT
cet-15443	3	1	isbn	isbn	PROPN
cet-15443	3	2	979	979	NUM
cet-15443	3	3	-	-	SYM
cet-15443	3	4	12	12	NUM
cet-15443	3	5	-	-	PUNCT
cet-15443	3	6	81206	81206	NUM
cet-15443	3	7	-	-	SYM
cet-15443	3	8	17	17	NUM
cet-15443	3	9	-	-	SYM
cet-15443	3	10	5	5	NUM
cet-15443	3	11	;	;	PUNCT
cet-15443	3	12	issn	issn	PROPN
cet-15443	3	13	2283	2283	NUM
cet-15443	3	14	-	-	SYM
cet-15443	3	15	9216	9216	NUM
cet-15443	3	16	computational	computational	ADJ
cet-15443	3	17	analysis	analysis	NOUN
cet-15443	3	18	of	of	ADP
cet-15443	3	19	the	the	DET
cet-15443	3	20	effect	effect	NOUN
cet-15443	3	21	of	of	ADP
cet-15443	3	22	inhibitor	inhibitor	NOUN
cet-15443	3	23	proteins	protein	NOUN
cet-15443	3	24	p21	p21	NOUN
cet-15443	3	25	/	/	SYM
cet-15443	3	26	p27	p27	NOUN
cet-15443	3	27	on	on	ADP
cet-15443	3	28	cell	cell	NOUN
cet-15443	3	29	cycle	cycle	NOUN
cet-15443	3	30	under	under	ADP
cet-15443	3	31	microgravity	microgravity	NOUN
cet-15443	3	32	conditions	condition	NOUN
cet-15443	3	33	gabriele	gabriele	PROPN
cet-15443	3	34	traversari*,a	traversari*,a	PROPN
cet-15443	3	35	,	,	PUNCT
cet-15443	3	36	antonio	antonio	PROPN
cet-15443	3	37	mario	mario	PROPN
cet-15443	3	38	loccia	loccia	PROPN
cet-15443	3	39	,	,	PUNCT
cet-15443	3	40	b	b	PROPN
cet-15443	3	41	,	,	PUNCT
cet-15443	3	42	alessandro	alessandro	PROPN
cet-15443	3	43	concasa	concasa	PROPN
cet-15443	3	44	,	,	PUNCT
cet-15443	3	45	b	b	PROPN
cet-15443	3	46	,	,	PUNCT
cet-15443	3	47	nicola	nicola	PROPN
cet-15443	3	48	laia	laia	PROPN
cet-15443	3	49	,	,	PUNCT
cet-15443	3	50	b	b	PROPN
cet-15443	3	51	,	,	PUNCT
cet-15443	3	52	alberto	alberto	PROPN
cet-15443	3	53	cincottia	cincottia	PROPN
cet-15443	3	54	,	,	PUNCT
cet-15443	3	55	b	b	PROPN
cet-15443	3	56	,	,	PUNCT
cet-15443	3	57	giacomo	giacomo	NOUN
cet-15443	3	58	caoa	caoa	NOUN
cet-15443	3	59	,	,	PUNCT
cet-15443	3	60	b	b	PROPN
cet-15443	3	61	a	a	DET
cet-15443	3	62	dipartimento	dipartimento	NOUN
cet-15443	3	63	di	di	X
cet-15443	3	64	ingegneria	ingegneria	PROPN
cet-15443	3	65	meccanica	meccanica	PROPN
cet-15443	3	66	,	,	PUNCT
cet-15443	3	67	chimica	chimica	PROPN
cet-15443	3	68	e	e	PROPN
cet-15443	3	69	dei	dei	PROPN
cet-15443	3	70	materiali	materiali	PROPN
cet-15443	3	71	,	,	PUNCT
cet-15443	3	72	università	università	PROPN
cet-15443	3	73	degli	degli	PROPN
cet-15443	3	74	studi	studi	PROPN
cet-15443	3	75	di	di	X
cet-15443	3	76	cagliari	cagliari	PROPN
cet-15443	3	77	,	,	PUNCT
cet-15443	3	78	via	via	ADP
cet-15443	3	79	marengo	marengo	PROPN
cet-15443	3	80	2	2	NUM
cet-15443	3	81	,	,	PUNCT
cet-15443	3	82	cagliari	cagliari	PROPN
cet-15443	3	83	,	,	PUNCT
cet-15443	3	84	09123	09123	NUM
cet-15443	3	85	,	,	PUNCT
cet-15443	3	86	italy	italy	PROPN
cet-15443	3	87	b	b	PROPN
cet-15443	3	88	centro	centro	PROPN
cet-15443	3	89	interdipartimentale	interdipartimentale	NOUN
cet-15443	3	90	di	di	X
cet-15443	3	91	ingegneria	ingegneria	PROPN
cet-15443	3	92	e	e	PROPN
cet-15443	3	93	scienze	scienze	PROPN
cet-15443	3	94	ambientali	ambientali	PROPN
cet-15443	3	95	(	(	PUNCT
cet-15443	3	96	cinsa	cinsa	PROPN
cet-15443	3	97	)	)	PUNCT
cet-15443	3	98	,	,	PUNCT
cet-15443	3	99	università	università	PROPN
cet-15443	3	100	degli	degli	PROPN
cet-15443	3	101	studi	studi	PROPN
cet-15443	3	102	di	di	X
cet-15443	3	103	cagliari	cagliari	PROPN
cet-15443	3	104	,	,	PUNCT
cet-15443	3	105	via	via	ADP
cet-15443	3	106	san	san	PROPN
cet-15443	3	107	giorgio	giorgio	PROPN
cet-15443	3	108	12	12	NUM
cet-15443	3	109	,	,	PUNCT
cet-15443	3	110	09124	09124	NUM
cet-15443	3	111	cagliari	cagliari	PROPN
cet-15443	3	112	,	,	PUNCT
cet-15443	3	113	italy	italy	PROPN
cet-15443	3	114	gabriele.traversari@unica.it	gabriele.traversari@unica.it	VERB
cet-15443	3	115	the	the	DET
cet-15443	3	116	cell	cell	NOUN
cet-15443	3	117	cycle	cycle	NOUN
cet-15443	3	118	progression	progression	NOUN
cet-15443	3	119	is	be	AUX
cet-15443	3	120	fundamental	fundamental	ADJ
cet-15443	3	121	for	for	SCONJ
cet-15443	3	122	the	the	DET
cet-15443	3	123	life	life	NOUN
cet-15443	3	124	of	of	ADP
cet-15443	3	125	all	all	DET
cet-15443	3	126	living	live	VERB
cet-15443	3	127	organisms	organism	NOUN
cet-15443	3	128	and	and	CCONJ
cet-15443	3	129	its	its	PRON
cet-15443	3	130	alteration	alteration	NOUN
cet-15443	3	131	from	from	ADP
cet-15443	3	132	physiological	physiological	ADJ
cet-15443	3	133	conditions	condition	NOUN
cet-15443	3	134	may	may	AUX
cet-15443	3	135	interfere	interfere	VERB
cet-15443	3	136	with	with	ADP
cet-15443	3	137	its	its	PRON
cet-15443	3	138	primary	primary	ADJ
cet-15443	3	139	function	function	NOUN
cet-15443	3	140	,	,	PUNCT
cet-15443	3	141	thus	thus	ADV
cet-15443	3	142	driving	drive	VERB
cet-15443	3	143	potentially	potentially	ADV
cet-15443	3	144	harmful	harmful	ADJ
cet-15443	3	145	consequences	consequence	NOUN
cet-15443	3	146	.	.	PUNCT
cet-15443	4	1	more	more	ADV
cet-15443	4	2	specifically	specifically	ADV
cet-15443	4	3	,	,	PUNCT
cet-15443	4	4	during	during	ADP
cet-15443	4	5	space	space	NOUN
cet-15443	4	6	missions	mission	NOUN
cet-15443	4	7	,	,	PUNCT
cet-15443	4	8	astronauts	astronaut	NOUN
cet-15443	4	9	are	be	AUX
cet-15443	4	10	continuously	continuously	ADV
cet-15443	4	11	exposed	expose	VERB
cet-15443	4	12	to	to	ADP
cet-15443	4	13	non	non	ADJ
cet-15443	4	14	-	-	ADJ
cet-15443	4	15	physiological	physiological	ADJ
cet-15443	4	16	conditions	condition	NOUN
cet-15443	4	17	due	due	ADP
cet-15443	4	18	to	to	ADP
cet-15443	4	19	microgravity	microgravity	NOUN
cet-15443	4	20	and	and	CCONJ
cet-15443	4	21	suffer	suffer	VERB
cet-15443	4	22	from	from	ADP
cet-15443	4	23	a	a	DET
cet-15443	4	24	series	series	NOUN
cet-15443	4	25	of	of	ADP
cet-15443	4	26	health	health	NOUN
cet-15443	4	27	issues	issue	NOUN
cet-15443	4	28	once	once	ADV
cet-15443	4	29	come	come	VERB
cet-15443	4	30	back	back	ADV
cet-15443	4	31	to	to	ADP
cet-15443	4	32	earth	earth	NOUN
cet-15443	4	33	;	;	PUNCT
cet-15443	4	34	exposure	exposure	NOUN
cet-15443	4	35	to	to	ADP
cet-15443	4	36	real	real	ADJ
cet-15443	4	37	or	or	CCONJ
cet-15443	4	38	simulated	simulate	VERB
cet-15443	4	39	microgravity	microgravity	NOUN
cet-15443	4	40	conditions	condition	NOUN
cet-15443	4	41	can	can	AUX
cet-15443	4	42	disrupt	disrupt	VERB
cet-15443	4	43	normal	normal	ADJ
cet-15443	4	44	cell	cell	NOUN
cet-15443	4	45	cycle	cycle	NOUN
cet-15443	4	46	regulation	regulation	NOUN
cet-15443	4	47	.	.	PUNCT
cet-15443	5	1	for	for	ADP
cet-15443	5	2	this	this	DET
cet-15443	5	3	reason	reason	NOUN
cet-15443	5	4	,	,	PUNCT
cet-15443	5	5	the	the	DET
cet-15443	5	6	possibility	possibility	NOUN
cet-15443	5	7	to	to	PART
cet-15443	5	8	predict	predict	VERB
cet-15443	5	9	any	any	DET
cet-15443	5	10	change	change	NOUN
cet-15443	5	11	in	in	ADP
cet-15443	5	12	cell	cell	NOUN
cet-15443	5	13	division	division	NOUN
cet-15443	5	14	time	time	NOUN
cet-15443	5	15	could	could	AUX
cet-15443	5	16	represent	represent	VERB
cet-15443	5	17	a	a	DET
cet-15443	5	18	valuable	valuable	ADJ
cet-15443	5	19	tool	tool	NOUN
cet-15443	5	20	for	for	ADP
cet-15443	5	21	understanding	understand	VERB
cet-15443	5	22	the	the	DET
cet-15443	5	23	pathologies	pathology	NOUN
cet-15443	5	24	and	and	CCONJ
cet-15443	5	25	health	health	NOUN
cet-15443	5	26	issues	issue	NOUN
cet-15443	5	27	experienced	experience	VERB
cet-15443	5	28	by	by	ADP
cet-15443	5	29	astronauts	astronaut	NOUN
cet-15443	5	30	during	during	ADP
cet-15443	5	31	their	their	PRON
cet-15443	5	32	time	time	NOUN
cet-15443	5	33	in	in	ADP
cet-15443	5	34	orbit	orbit	NOUN
cet-15443	5	35	.	.	PUNCT
cet-15443	6	1	in	in	ADP
cet-15443	6	2	this	this	DET
cet-15443	6	3	study	study	NOUN
cet-15443	6	4	,	,	PUNCT
cet-15443	6	5	we	we	PRON
cet-15443	6	6	employed	employ	VERB
cet-15443	6	7	a	a	DET
cet-15443	6	8	previously	previously	ADV
cet-15443	6	9	developed	develop	VERB
cet-15443	6	10	mathematical	mathematical	ADJ
cet-15443	6	11	model	model	NOUN
cet-15443	6	12	to	to	PART
cet-15443	6	13	simulate	simulate	VERB
cet-15443	6	14	the	the	DET
cet-15443	6	15	impact	impact	NOUN
cet-15443	6	16	of	of	ADP
cet-15443	6	17	the	the	DET
cet-15443	6	18	inhibitor	inhibitor	NOUN
cet-15443	6	19	proteins	protein	NOUN
cet-15443	6	20	p21	p21	NOUN
cet-15443	6	21	and	and	CCONJ
cet-15443	6	22	p27	p27	NOUN
cet-15443	6	23	on	on	ADP
cet-15443	6	24	cell	cell	NOUN
cet-15443	6	25	cycle	cycle	NOUN
cet-15443	6	26	progression	progression	NOUN
cet-15443	6	27	.	.	PUNCT
cet-15443	7	1	these	these	DET
cet-15443	7	2	proteins	protein	NOUN
cet-15443	7	3	are	be	AUX
cet-15443	7	4	known	know	VERB
cet-15443	7	5	to	to	PART
cet-15443	7	6	be	be	AUX
cet-15443	7	7	overexpressed	overexpresse	VERB
cet-15443	7	8	under	under	ADP
cet-15443	7	9	microgravity	microgravity	NOUN
cet-15443	7	10	conditions	condition	NOUN
cet-15443	7	11	,	,	PUNCT
cet-15443	7	12	potentially	potentially	ADV
cet-15443	7	13	leading	lead	VERB
cet-15443	7	14	to	to	AUX
cet-15443	7	15	altered	alter	VERB
cet-15443	7	16	or	or	CCONJ
cet-15443	7	17	even	even	ADV
cet-15443	7	18	arrested	arrest	VERB
cet-15443	7	19	cell	cell	NOUN
cet-15443	7	20	division	division	NOUN
cet-15443	7	21	,	,	PUNCT
cet-15443	7	22	depending	depend	VERB
cet-15443	7	23	on	on	ADP
cet-15443	7	24	the	the	DET
cet-15443	7	25	extent	extent	NOUN
cet-15443	7	26	of	of	ADP
cet-15443	7	27	the	the	DET
cet-15443	7	28	overexpression	overexpression	NOUN
cet-15443	7	29	.	.	PUNCT
cet-15443	8	1	in	in	ADP
cet-15443	8	2	particular	particular	ADJ
cet-15443	8	3	,	,	PUNCT
cet-15443	8	4	the	the	DET
cet-15443	8	5	aim	aim	NOUN
cet-15443	8	6	of	of	ADP
cet-15443	8	7	this	this	DET
cet-15443	8	8	work	work	NOUN
cet-15443	8	9	is	be	AUX
cet-15443	8	10	the	the	DET
cet-15443	8	11	analysis	analysis	NOUN
cet-15443	8	12	of	of	ADP
cet-15443	8	13	p21	p21	NOUN
cet-15443	8	14	/	/	SYM
cet-15443	8	15	p27	p27	NOUN
cet-15443	8	16	over	over	ADP
cet-15443	8	17	expression	expression	NOUN
cet-15443	8	18	induced	induce	VERB
cet-15443	8	19	by	by	ADP
cet-15443	8	20	microgravity	microgravity	NOUN
cet-15443	8	21	,	,	PUNCT
cet-15443	8	22	with	with	ADP
cet-15443	8	23	particular	particular	ADJ
cet-15443	8	24	attention	attention	NOUN
cet-15443	8	25	to	to	ADP
cet-15443	8	26	its	its	PRON
cet-15443	8	27	effect	effect	NOUN
cet-15443	8	28	on	on	ADP
cet-15443	8	29	cell	cell	NOUN
cet-15443	8	30	duplication	duplication	NOUN
cet-15443	8	31	time	time	NOUN
cet-15443	8	32	and	and	CCONJ
cet-15443	8	33	quality	quality	NOUN
cet-15443	8	34	.	.	PUNCT
cet-15443	9	1	indeed	indeed	ADV
cet-15443	9	2	,	,	PUNCT
cet-15443	9	3	depending	depend	VERB
cet-15443	9	4	on	on	ADP
cet-15443	9	5	the	the	DET
cet-15443	9	6	extent	extent	NOUN
cet-15443	9	7	of	of	ADP
cet-15443	9	8	such	such	DET
cet-15443	9	9	an	an	DET
cet-15443	9	10	over	over	NOUN
cet-15443	9	11	expression	expression	NOUN
cet-15443	9	12	,	,	PUNCT
cet-15443	9	13	not	not	PART
cet-15443	9	14	only	only	ADV
cet-15443	9	15	duplication	duplication	NOUN
cet-15443	9	16	time	time	NOUN
cet-15443	9	17	varies	vary	VERB
cet-15443	9	18	but	but	CCONJ
cet-15443	9	19	also	also	ADV
cet-15443	9	20	cellular	cellular	ADJ
cet-15443	9	21	abnormalities	abnormality	NOUN
cet-15443	9	22	such	such	ADJ
cet-15443	9	23	as	as	ADP
cet-15443	9	24	biperiodic	biperiodic	ADJ
cet-15443	9	25	duplication	duplication	NOUN
cet-15443	9	26	,	,	PUNCT
cet-15443	9	27	endoreplication	endoreplication	NOUN
cet-15443	9	28	or	or	CCONJ
cet-15443	9	29	tetraploidy	tetraploidy	ADJ
cet-15443	9	30	,	,	PUNCT
cet-15443	9	31	as	as	ADV
cet-15443	9	32	well	well	ADV
cet-15443	9	33	as	as	ADP
cet-15443	9	34	cessation	cessation	NOUN
cet-15443	9	35	of	of	ADP
cet-15443	9	36	cell	cell	NOUN
cet-15443	9	37	replication	replication	NOUN
cet-15443	9	38	may	may	AUX
cet-15443	9	39	take	take	VERB
cet-15443	9	40	place	place	NOUN
cet-15443	9	41	.	.	PUNCT
cet-15443	10	1	1	1	X
cet-15443	10	2	.	.	X
cet-15443	10	3	introduction	introduction	NOUN
cet-15443	10	4	from	from	ADP
cet-15443	10	5	a	a	DET
cet-15443	10	6	chemical	chemical	ADJ
cet-15443	10	7	engineering	engineering	NOUN
cet-15443	10	8	point	point	NOUN
cet-15443	10	9	of	of	ADP
cet-15443	10	10	view	view	NOUN
cet-15443	10	11	,	,	PUNCT
cet-15443	10	12	cell	cell	NOUN
cet-15443	10	13	cycle	cycle	NOUN
cet-15443	10	14	consists	consist	VERB
cet-15443	10	15	of	of	ADP
cet-15443	10	16	a	a	DET
cet-15443	10	17	cascade	cascade	NOUN
cet-15443	10	18	of	of	ADP
cet-15443	10	19	complex	complex	ADJ
cet-15443	10	20	enzymatic	enzymatic	ADJ
cet-15443	10	21	reactions	reaction	NOUN
cet-15443	10	22	aiming	aim	VERB
cet-15443	10	23	to	to	ADP
cet-15443	10	24	the	the	DET
cet-15443	10	25	synthesis	synthesis	NOUN
cet-15443	10	26	of	of	ADP
cet-15443	10	27	biological	biological	ADJ
cet-15443	10	28	molecules	molecule	NOUN
cet-15443	10	29	required	require	VERB
cet-15443	10	30	for	for	ADP
cet-15443	10	31	cell	cell	NOUN
cet-15443	10	32	duplication	duplication	NOUN
cet-15443	10	33	.	.	PUNCT
cet-15443	11	1	it	it	PRON
cet-15443	11	2	is	be	AUX
cet-15443	11	3	typically	typically	ADV
cet-15443	11	4	divided	divide	VERB
cet-15443	11	5	in	in	ADP
cet-15443	11	6	different	different	ADJ
cet-15443	11	7	phases	phase	NOUN
cet-15443	11	8	as	as	SCONJ
cet-15443	11	9	shown	show	VERB
cet-15443	11	10	in	in	ADP
cet-15443	11	11	figure	figure	NOUN
cet-15443	11	12	1	1	NUM
cet-15443	11	13	.	.	PUNCT
cet-15443	12	1	figure	figure	NOUN
cet-15443	12	2	1	1	NUM
cet-15443	12	3	:	:	PUNCT
cet-15443	12	4	scheme	scheme	NOUN
cet-15443	12	5	of	of	ADP
cet-15443	12	6	a	a	DET
cet-15443	12	7	standard	standard	ADJ
cet-15443	12	8	cell	cell	NOUN
cet-15443	12	9	cycle	cycle	NOUN
cet-15443	12	10	.	.	PUNCT
cet-15443	13	1	g1	g1	PROPN
cet-15443	13	2	(	(	PUNCT
cet-15443	13	3	gap	gap	NOUN
cet-15443	13	4	1	1	NUM
cet-15443	13	5	,	,	PUNCT
cet-15443	13	6	cell	cell	NOUN
cet-15443	13	7	growth	growth	NOUN
cet-15443	13	8	after	after	ADP
cet-15443	13	9	mitosis	mitosis	NOUN
cet-15443	13	10	)	)	PUNCT
cet-15443	13	11	;	;	PUNCT
cet-15443	13	12	s	s	X
cet-15443	13	13	(	(	PUNCT
cet-15443	13	14	synthesis	synthesis	NOUN
cet-15443	13	15	,	,	PUNCT
cet-15443	13	16	dna	dna	NOUN
cet-15443	13	17	duplication	duplication	NOUN
cet-15443	13	18	)	)	PUNCT
cet-15443	13	19	;	;	PUNCT
cet-15443	13	20	g2	g2	PROPN
cet-15443	13	21	(	(	PUNCT
cet-15443	13	22	gap	gap	NOUN
cet-15443	13	23	2	2	NUM
cet-15443	13	24	,	,	PUNCT
cet-15443	13	25	cell	cell	NOUN
cet-15443	13	26	growth	growth	NOUN
cet-15443	13	27	in	in	ADP
cet-15443	13	28	preparation	preparation	NOUN
cet-15443	13	29	for	for	ADP
cet-15443	13	30	mitosis	mitosis	NOUN
cet-15443	13	31	)	)	PUNCT
cet-15443	13	32	,	,	PUNCT
cet-15443	13	33	m	m	PROPN
cet-15443	13	34	(	(	PUNCT
cet-15443	13	35	mitosis	mitosis	NOUN
cet-15443	13	36	,	,	PUNCT
cet-15443	13	37	cell	cell	NOUN
cet-15443	13	38	division	division	NOUN
cet-15443	13	39	)	)	PUNCT
cet-15443	13	40	;	;	PUNCT
cet-15443	13	41	and	and	CCONJ
cet-15443	13	42	g0	g0	NOUN
cet-15443	13	43	(	(	PUNCT
cet-15443	13	44	gap	gap	NOUN
cet-15443	13	45	0	0	NUM
cet-15443	13	46	,	,	PUNCT
cet-15443	13	47	resting	rest	VERB
cet-15443	13	48	phase	phase	NOUN
cet-15443	13	49	,	,	PUNCT
cet-15443	13	50	cell	cell	NOUN
cet-15443	13	51	leaves	leave	VERB
cet-15443	13	52	the	the	DET
cet-15443	13	53	cycle	cycle	NOUN
cet-15443	13	54	and	and	CCONJ
cet-15443	13	55	duplication	duplication	NOUN
cet-15443	13	56	stops	stop	NOUN
cet-15443	13	57	)	)	PUNCT
cet-15443	13	58	.	.	PUNCT
cet-15443	14	1	1153	1153	NUM
cet-15443	14	2	mailto:gabriele.traversari@unica.it	mailto:gabriele.traversari@unica.it	PROPN
cet-15443	14	3	after	after	ADP
cet-15443	14	4	cell	cell	NOUN
cet-15443	14	5	division	division	NOUN
cet-15443	14	6	,	,	PUNCT
cet-15443	14	7	the	the	DET
cet-15443	14	8	newborn	newborn	ADJ
cet-15443	14	9	cells	cell	NOUN
cet-15443	14	10	begin	begin	VERB
cet-15443	14	11	their	their	PRON
cet-15443	14	12	cycle	cycle	NOUN
cet-15443	14	13	from	from	ADP
cet-15443	14	14	the	the	DET
cet-15443	14	15	g1	g1	PROPN
cet-15443	14	16	phase	phase	NOUN
cet-15443	14	17	,	,	PUNCT
cet-15443	14	18	where	where	SCONJ
cet-15443	14	19	they	they	PRON
cet-15443	14	20	undergo	undergo	VERB
cet-15443	14	21	growth	growth	NOUN
cet-15443	14	22	through	through	ADP
cet-15443	14	23	biosynthetic	biosynthetic	ADJ
cet-15443	14	24	activities	activity	NOUN
cet-15443	14	25	and	and	CCONJ
cet-15443	14	26	the	the	DET
cet-15443	14	27	replication	replication	NOUN
cet-15443	14	28	of	of	ADP
cet-15443	14	29	cytoplasmic	cytoplasmic	ADJ
cet-15443	14	30	organelles	organelle	NOUN
cet-15443	14	31	.	.	PUNCT
cet-15443	15	1	once	once	ADV
cet-15443	15	2	g1	g1	PROPN
cet-15443	15	3	is	be	AUX
cet-15443	15	4	complete	complete	ADJ
cet-15443	15	5	,	,	PUNCT
cet-15443	15	6	cells	cell	NOUN
cet-15443	15	7	enter	enter	VERB
cet-15443	15	8	the	the	DET
cet-15443	15	9	s	s	NOUN
cet-15443	15	10	phase	phase	NOUN
cet-15443	15	11	,	,	PUNCT
cet-15443	15	12	devoted	devote	VERB
cet-15443	15	13	to	to	ADP
cet-15443	15	14	dna	dna	PROPN
cet-15443	15	15	duplication	duplication	NOUN
cet-15443	15	16	,	,	PUNCT
cet-15443	15	17	before	before	ADP
cet-15443	15	18	transiting	transit	VERB
cet-15443	15	19	into	into	ADP
cet-15443	15	20	the	the	DET
cet-15443	15	21	g2	g2	PROPN
cet-15443	15	22	phase	phase	NOUN
cet-15443	15	23	,	,	PUNCT
cet-15443	15	24	where	where	SCONJ
cet-15443	15	25	proteins	protein	NOUN
cet-15443	15	26	and	and	CCONJ
cet-15443	15	27	other	other	ADJ
cet-15443	15	28	cellular	cellular	ADJ
cet-15443	15	29	components	component	NOUN
cet-15443	15	30	necessary	necessary	ADJ
cet-15443	15	31	for	for	ADP
cet-15443	15	32	mitotic	mitotic	ADJ
cet-15443	15	33	division	division	NOUN
cet-15443	15	34	are	be	AUX
cet-15443	15	35	synthesized	synthesize	VERB
cet-15443	15	36	.	.	PUNCT
cet-15443	16	1	eventually	eventually	ADV
cet-15443	16	2	the	the	DET
cet-15443	16	3	cells	cell	NOUN
cet-15443	16	4	enter	enter	VERB
cet-15443	16	5	the	the	DET
cet-15443	16	6	m	m	NOUN
cet-15443	16	7	phase	phase	NOUN
cet-15443	16	8	(	(	PUNCT
cet-15443	16	9	mitosis	mitosis	NOUN
cet-15443	16	10	)	)	PUNCT
cet-15443	16	11	,	,	PUNCT
cet-15443	16	12	where	where	SCONJ
cet-15443	16	13	they	they	PRON
cet-15443	16	14	divide	divide	VERB
cet-15443	16	15	into	into	ADP
cet-15443	16	16	two	two	NUM
cet-15443	16	17	newborn	newborn	ADJ
cet-15443	16	18	,	,	PUNCT
cet-15443	16	19	daughter	daughter	NOUN
cet-15443	16	20	cells	cell	NOUN
cet-15443	16	21	.	.	PUNCT
cet-15443	17	1	when	when	SCONJ
cet-15443	17	2	any	any	DET
cet-15443	17	3	variation	variation	NOUN
cet-15443	17	4	from	from	ADP
cet-15443	17	5	the	the	DET
cet-15443	17	6	physiological	physiological	ADJ
cet-15443	17	7	-	-	PUNCT
cet-15443	17	8	homeostatic	homeostatic	ADJ
cet-15443	17	9	state	state	NOUN
cet-15443	17	10	takes	take	VERB
cet-15443	17	11	place	place	NOUN
cet-15443	17	12	,	,	PUNCT
cet-15443	17	13	cells	cell	NOUN
cet-15443	17	14	may	may	AUX
cet-15443	17	15	exit	exit	VERB
cet-15443	17	16	the	the	DET
cet-15443	17	17	cell	cell	NOUN
cet-15443	17	18	cycle	cycle	NOUN
cet-15443	17	19	to	to	PART
cet-15443	17	20	enter	enter	VERB
cet-15443	17	21	a	a	DET
cet-15443	17	22	quiescent	quiescent	ADJ
cet-15443	17	23	or	or	CCONJ
cet-15443	17	24	senescent	senescent	ADJ
cet-15443	17	25	state	state	NOUN
cet-15443	17	26	,	,	PUNCT
cet-15443	17	27	known	know	VERB
cet-15443	17	28	as	as	ADP
cet-15443	17	29	the	the	DET
cet-15443	17	30	resting	rest	VERB
cet-15443	17	31	phase	phase	NOUN
cet-15443	17	32	g0	g0	PROPN
cet-15443	17	33	.	.	PUNCT
cet-15443	18	1	the	the	DET
cet-15443	18	2	cell	cell	NOUN
cet-15443	18	3	cycle	cycle	NOUN
cet-15443	18	4	with	with	ADP
cet-15443	18	5	its	its	PRON
cet-15443	18	6	intricate	intricate	ADJ
cet-15443	18	7	biochemical	biochemical	ADJ
cet-15443	18	8	pathways	pathway	NOUN
cet-15443	18	9	was	be	AUX
cet-15443	18	10	extensively	extensively	ADV
cet-15443	18	11	studied	study	VERB
cet-15443	18	12	in	in	ADP
cet-15443	18	13	medical	medical	ADJ
cet-15443	18	14	science	science	NOUN
cet-15443	18	15	to	to	PART
cet-15443	18	16	provide	provide	VERB
cet-15443	18	17	a	a	DET
cet-15443	18	18	deep	deep	ADJ
cet-15443	18	19	understanding	understanding	NOUN
cet-15443	18	20	of	of	ADP
cet-15443	18	21	its	its	PRON
cet-15443	18	22	core	core	NOUN
cet-15443	18	23	mechanisms	mechanism	NOUN
cet-15443	18	24	.	.	PUNCT
cet-15443	19	1	however	however	ADV
cet-15443	19	2	,	,	PUNCT
cet-15443	19	3	the	the	DET
cet-15443	19	4	regulatory	regulatory	ADJ
cet-15443	19	5	mechanisms	mechanism	NOUN
cet-15443	19	6	of	of	ADP
cet-15443	19	7	the	the	DET
cet-15443	19	8	cell	cell	NOUN
cet-15443	19	9	cycle	cycle	NOUN
cet-15443	19	10	are	be	AUX
cet-15443	19	11	less	less	ADV
cet-15443	19	12	clear	clear	ADJ
cet-15443	19	13	in	in	ADP
cet-15443	19	14	presence	presence	NOUN
cet-15443	19	15	of	of	ADP
cet-15443	19	16	cancer	cancer	NOUN
cet-15443	19	17	,	,	PUNCT
cet-15443	19	18	aging	aging	NOUN
cet-15443	19	19	processes	process	NOUN
cet-15443	19	20	as	as	ADV
cet-15443	19	21	well	well	ADV
cet-15443	19	22	as	as	ADP
cet-15443	19	23	under	under	ADP
cet-15443	19	24	microgravity	microgravity	NOUN
cet-15443	19	25	conditions	condition	NOUN
cet-15443	19	26	.	.	PUNCT
cet-15443	20	1	previous	previous	ADJ
cet-15443	20	2	computational	computational	ADJ
cet-15443	20	3	works	work	NOUN
cet-15443	20	4	(	(	PUNCT
cet-15443	20	5	pisu	pisu	NOUN
cet-15443	20	6	et	et	PROPN
cet-15443	20	7	al	al	PROPN
cet-15443	20	8	.	.	PROPN
cet-15443	20	9	2015	2015	NUM
cet-15443	20	10	,	,	PUNCT
cet-15443	20	11	2022	2022	NUM
cet-15443	20	12	)	)	PUNCT
cet-15443	20	13	combined	combine	VERB
cet-15443	20	14	a	a	DET
cet-15443	20	15	population	population	NOUN
cet-15443	20	16	balance	balance	NOUN
cet-15443	20	17	approach	approach	NOUN
cet-15443	20	18	with	with	ADP
cet-15443	20	19	a	a	DET
cet-15443	20	20	cell	cell	NOUN
cet-15443	20	21	cycle	cycle	NOUN
cet-15443	20	22	phases	phase	NOUN
cet-15443	20	23	model	model	NOUN
cet-15443	20	24	(	(	PUNCT
cet-15443	20	25	gérard	gérard	NOUN
cet-15443	20	26	and	and	CCONJ
cet-15443	20	27	golbeter	golbeter	NOUN
cet-15443	20	28	,	,	PUNCT
cet-15443	20	29	2009	2009	NUM
cet-15443	20	30	,	,	PUNCT
cet-15443	20	31	2012	2012	NUM
cet-15443	20	32	,	,	PUNCT
cet-15443	20	33	2014	2014	NUM
cet-15443	20	34	)	)	PUNCT
cet-15443	20	35	to	to	PART
cet-15443	20	36	simulate	simulate	VERB
cet-15443	20	37	the	the	DET
cet-15443	20	38	culture	culture	NOUN
cet-15443	20	39	growth	growth	NOUN
cet-15443	20	40	quantifying	quantify	VERB
cet-15443	20	41	cell	cell	NOUN
cet-15443	20	42	volume	volume	NOUN
cet-15443	20	43	and	and	CCONJ
cet-15443	20	44	age	age	NOUN
cet-15443	20	45	distributions	distribution	NOUN
cet-15443	20	46	.	.	PUNCT
cet-15443	21	1	specifically	specifically	ADV
cet-15443	21	2	,	,	PUNCT
cet-15443	21	3	the	the	DET
cet-15443	21	4	cyclin	cyclin	PROPN
cet-15443	21	5	/	/	SYM
cet-15443	21	6	cyclin	cyclin	PROPN
cet-15443	21	7	dependent	dependent	PROPN
cet-15443	21	8	kinase	kinase	PROPN
cet-15443	21	9	(	(	PUNCT
cet-15443	21	10	cyclin	cyclin	NOUN
cet-15443	21	11	/	/	SYM
cet-15443	21	12	cdk	cdk	PROPN
cet-15443	21	13	)	)	PUNCT
cet-15443	21	14	network	network	NOUN
cet-15443	21	15	model	model	NOUN
cet-15443	21	16	(	(	PUNCT
cet-15443	21	17	gérard	gérard	NOUN
cet-15443	21	18	and	and	CCONJ
cet-15443	21	19	golbeter	golbeter	NOUN
cet-15443	21	20	,	,	PUNCT
cet-15443	21	21	2009	2009	NUM
cet-15443	21	22	,	,	PUNCT
cet-15443	21	23	2012	2012	NUM
cet-15443	21	24	,	,	PUNCT
cet-15443	21	25	2014	2014	NUM
cet-15443	21	26	)	)	PUNCT
cet-15443	21	27	was	be	AUX
cet-15443	21	28	used	use	VERB
cet-15443	21	29	under	under	ADP
cet-15443	21	30	physiological	physiological	ADJ
cet-15443	21	31	conditions	condition	NOUN
cet-15443	21	32	,	,	PUNCT
cet-15443	21	33	inhibiting	inhibit	VERB
cet-15443	21	34	effects	effect	NOUN
cet-15443	21	35	of	of	ADP
cet-15443	21	36	cytostatic	cytostatic	ADJ
cet-15443	21	37	drugs	drug	NOUN
cet-15443	21	38	or	or	CCONJ
cet-15443	21	39	the	the	DET
cet-15443	21	40	promoting	promote	VERB
cet-15443	21	41	effects	effect	NOUN
cet-15443	21	42	of	of	ADP
cet-15443	21	43	growth	growth	NOUN
cet-15443	21	44	factors	factor	NOUN
cet-15443	21	45	to	to	PART
cet-15443	21	46	quantify	quantify	VERB
cet-15443	21	47	the	the	DET
cet-15443	21	48	elapsed	elapse	VERB
cet-15443	21	49	time	time	NOUN
cet-15443	21	50	of	of	ADP
cet-15443	21	51	each	each	DET
cet-15443	21	52	cell	cell	NOUN
cet-15443	21	53	cycle	cycle	NOUN
cet-15443	21	54	required	require	VERB
cet-15443	21	55	to	to	PART
cet-15443	21	56	estimate	estimate	VERB
cet-15443	21	57	the	the	DET
cet-15443	21	58	kinetic	kinetic	ADJ
cet-15443	21	59	rate	rate	NOUN
cet-15443	21	60	constants	constant	NOUN
cet-15443	21	61	in	in	ADP
cet-15443	21	62	the	the	DET
cet-15443	21	63	population	population	NOUN
cet-15443	21	64	balance	balance	NOUN
cet-15443	21	65	model	model	NOUN
cet-15443	21	66	(	(	PUNCT
cet-15443	21	67	pisu	pisu	NOUN
cet-15443	21	68	et	et	PROPN
cet-15443	21	69	al	al	PROPN
cet-15443	21	70	.	.	PROPN
cet-15443	21	71	2015	2015	NUM
cet-15443	21	72	,	,	PUNCT
cet-15443	21	73	2022	2022	NUM
cet-15443	21	74	)	)	PUNCT
cet-15443	21	75	.	.	PUNCT
cet-15443	22	1	in	in	ADP
cet-15443	22	2	this	this	DET
cet-15443	22	3	context	context	NOUN
cet-15443	22	4	,	,	PUNCT
cet-15443	22	5	it	it	PRON
cet-15443	22	6	is	be	AUX
cet-15443	22	7	important	important	ADJ
cet-15443	22	8	to	to	PART
cet-15443	22	9	relate	relate	VERB
cet-15443	22	10	the	the	DET
cet-15443	22	11	inhibitory	inhibitory	NOUN
cet-15443	22	12	or	or	CCONJ
cet-15443	22	13	promoting	promote	VERB
cet-15443	22	14	effects	effect	NOUN
cet-15443	22	15	of	of	ADP
cet-15443	22	16	biochemical	biochemical	ADJ
cet-15443	22	17	agents	agent	NOUN
cet-15443	22	18	and	and	CCONJ
cet-15443	22	19	stimuli	stimulus	NOUN
cet-15443	22	20	to	to	ADP
cet-15443	22	21	the	the	DET
cet-15443	22	22	duplication	duplication	NOUN
cet-15443	22	23	time	time	NOUN
cet-15443	22	24	.	.	PUNCT
cet-15443	23	1	thus	thus	ADV
cet-15443	23	2	,	,	PUNCT
cet-15443	23	3	it	it	PRON
cet-15443	23	4	has	have	AUX
cet-15443	23	5	been	be	AUX
cet-15443	23	6	identified	identify	VERB
cet-15443	23	7	an	an	DET
cet-15443	23	8	important	important	ADJ
cet-15443	23	9	parameter	parameter	NOUN
cet-15443	23	10	(	(	PUNCT
cet-15443	23	11	𝑣𝑠1𝑝27	𝑣𝑠1𝑝27	PROPN
cet-15443	23	12	)	)	PUNCT
cet-15443	23	13	mimicking	mimic	VERB
cet-15443	23	14	proteins	protein	NOUN
cet-15443	23	15	p21	p21	NOUN
cet-15443	23	16	/	/	SYM
cet-15443	23	17	p27	p27	PROPN
cet-15443	23	18	basal	basal	NOUN
cet-15443	23	19	production	production	NOUN
cet-15443	23	20	(	(	PUNCT
cet-15443	23	21	gérard	gérard	NOUN
cet-15443	23	22	and	and	CCONJ
cet-15443	23	23	golbeter	golbeter	NOUN
cet-15443	23	24	,	,	PUNCT
cet-15443	23	25	2012	2012	NUM
cet-15443	23	26	)	)	PUNCT
cet-15443	23	27	responsible	responsible	ADJ
cet-15443	23	28	for	for	ADP
cet-15443	23	29	an	an	DET
cet-15443	23	30	inhibitory	inhibitory	ADJ
cet-15443	23	31	effect	effect	NOUN
cet-15443	23	32	of	of	ADP
cet-15443	23	33	the	the	DET
cet-15443	23	34	cell	cell	NOUN
cet-15443	23	35	cycle	cycle	NOUN
cet-15443	23	36	.	.	PUNCT
cet-15443	24	1	high	high	ADJ
cet-15443	24	2	value	value	NOUN
cet-15443	24	3	of	of	ADP
cet-15443	24	4	this	this	DET
cet-15443	24	5	parameter	parameter	NOUN
cet-15443	24	6	representing	represent	VERB
cet-15443	24	7	high	high	ADJ
cet-15443	24	8	p21	p21	NOUN
cet-15443	24	9	/	/	SYM
cet-15443	24	10	p27	p27	NOUN
cet-15443	24	11	protein	protein	NOUN
cet-15443	24	12	content	content	NOUN
cet-15443	24	13	allow	allow	VERB
cet-15443	24	14	to	to	PART
cet-15443	24	15	simulate	simulate	VERB
cet-15443	24	16	the	the	DET
cet-15443	24	17	condition	condition	NOUN
cet-15443	24	18	leading	lead	VERB
cet-15443	24	19	to	to	ADP
cet-15443	24	20	the	the	DET
cet-15443	24	21	cell	cell	NOUN
cet-15443	24	22	cycle	cycle	NOUN
cet-15443	24	23	inhibition	inhibition	NOUN
cet-15443	24	24	or	or	CCONJ
cet-15443	24	25	even	even	ADV
cet-15443	24	26	arrest	arrest	VERB
cet-15443	24	27	.	.	PUNCT
cet-15443	25	1	this	this	DET
cet-15443	25	2	semi	semi	ADJ
cet-15443	25	3	quantitative	quantitative	ADJ
cet-15443	25	4	analysis	analysis	NOUN
cet-15443	25	5	on	on	ADP
cet-15443	25	6	the	the	DET
cet-15443	25	7	effects	effect	NOUN
cet-15443	25	8	of	of	ADP
cet-15443	25	9	p21	p21	NOUN
cet-15443	25	10	/	/	SYM
cet-15443	25	11	p27	p27	PROPN
cet-15443	25	12	basal	basal	NOUN
cet-15443	25	13	production	production	NOUN
cet-15443	25	14	appears	appear	VERB
cet-15443	25	15	to	to	PART
cet-15443	25	16	be	be	AUX
cet-15443	25	17	a	a	DET
cet-15443	25	18	promising	promising	ADJ
cet-15443	25	19	approach	approach	NOUN
cet-15443	25	20	to	to	PART
cet-15443	25	21	assess	assess	VERB
cet-15443	25	22	the	the	DET
cet-15443	25	23	p21	p21	NOUN
cet-15443	25	24	/	/	SYM
cet-15443	25	25	p27	p27	NOUN
cet-15443	25	26	protein	protein	NOUN
cet-15443	25	27	roles	role	VERB
cet-15443	25	28	on	on	ADP
cet-15443	25	29	the	the	DET
cet-15443	25	30	cell	cell	NOUN
cet-15443	25	31	cycle	cycle	NOUN
cet-15443	25	32	under	under	ADP
cet-15443	25	33	external	external	ADJ
cet-15443	25	34	stimuli	stimulus	NOUN
cet-15443	25	35	such	such	ADJ
cet-15443	25	36	as	as	ADP
cet-15443	25	37	microgravity	microgravity	NOUN
cet-15443	25	38	conditions	condition	NOUN
cet-15443	25	39	.	.	PUNCT
cet-15443	26	1	using	use	VERB
cet-15443	26	2	a	a	DET
cet-15443	26	3	random	random	ADJ
cet-15443	26	4	positioning	positioning	NOUN
cet-15443	26	5	machine	machine	NOUN
cet-15443	26	6	(	(	PUNCT
cet-15443	26	7	rpm	rpm	PROPN
cet-15443	26	8	)	)	PUNCT
cet-15443	26	9	,	,	PUNCT
cet-15443	26	10	human	human	ADJ
cet-15443	26	11	cells	cell	NOUN
cet-15443	26	12	,	,	PUNCT
cet-15443	26	13	initially	initially	ADV
cet-15443	26	14	synchronized	synchronize	VERB
cet-15443	26	15	in	in	ADP
cet-15443	26	16	the	the	DET
cet-15443	26	17	g1	g1	PROPN
cet-15443	26	18	phase	phase	NOUN
cet-15443	26	19	,	,	PUNCT
cet-15443	26	20	overexpressed	overexpresse	VERB
cet-15443	26	21	p21	p21	NOUN
cet-15443	26	22	inhibitor	inhibitor	NOUN
cet-15443	26	23	protein	protein	NOUN
cet-15443	26	24	genes	gene	NOUN
cet-15443	26	25	after	after	ADP
cet-15443	26	26	exposure	exposure	NOUN
cet-15443	26	27	to	to	ADP
cet-15443	26	28	simulated	simulate	VERB
cet-15443	26	29	microgravity	microgravity	NOUN
cet-15443	26	30	,	,	PUNCT
cet-15443	26	31	and	and	CCONJ
cet-15443	26	32	even	even	ADV
cet-15443	26	33	fail	fail	VERB
cet-15443	26	34	to	to	PART
cet-15443	26	35	duplicate	duplicate	VERB
cet-15443	26	36	within	within	ADP
cet-15443	26	37	the	the	DET
cet-15443	26	38	typical	typical	ADJ
cet-15443	26	39	24	24	NUM
cet-15443	26	40	-	-	PUNCT
cet-15443	26	41	hour	hour	NOUN
cet-15443	26	42	temporal	temporal	ADJ
cet-15443	26	43	interval	interval	NOUN
cet-15443	26	44	(	(	PUNCT
cet-15443	26	45	coinu	coinu	NOUN
cet-15443	26	46	et	et	NOUN
cet-15443	26	47	al	al	PROPN
cet-15443	26	48	.	.	PROPN
cet-15443	26	49	2006	2006	NUM
cet-15443	26	50	)	)	PUNCT
cet-15443	26	51	.	.	PUNCT
cet-15443	27	1	even	even	ADV
cet-15443	27	2	though	though	SCONJ
cet-15443	27	3	the	the	DET
cet-15443	27	4	biological	biological	ADJ
cet-15443	27	5	mechanism	mechanism	NOUN
cet-15443	27	6	for	for	ADP
cet-15443	27	7	such	such	DET
cet-15443	27	8	an	an	DET
cet-15443	27	9	over	over	NOUN
cet-15443	27	10	expression	expression	NOUN
cet-15443	27	11	is	be	AUX
cet-15443	27	12	not	not	PART
cet-15443	27	13	clear	clear	ADJ
cet-15443	27	14	,	,	PUNCT
cet-15443	27	15	this	this	DET
cet-15443	27	16	finding	finding	NOUN
cet-15443	27	17	suggests	suggest	VERB
cet-15443	27	18	that	that	SCONJ
cet-15443	27	19	cells	cell	NOUN
cet-15443	27	20	require	require	VERB
cet-15443	27	21	more	more	ADJ
cet-15443	27	22	time	time	NOUN
cet-15443	27	23	to	to	PART
cet-15443	27	24	duplicate	duplicate	VERB
cet-15443	27	25	when	when	SCONJ
cet-15443	27	26	larger	large	ADJ
cet-15443	27	27	p21	p21	NOUN
cet-15443	27	28	inhibitor	inhibitor	NOUN
cet-15443	27	29	proteins	protein	NOUN
cet-15443	27	30	levels	level	NOUN
cet-15443	27	31	are	be	AUX
cet-15443	27	32	reached	reach	VERB
cet-15443	27	33	under	under	ADP
cet-15443	27	34	microgravity	microgravity	NOUN
cet-15443	27	35	conditions	condition	NOUN
cet-15443	27	36	.	.	PUNCT
cet-15443	28	1	thus	thus	ADV
cet-15443	28	2	,	,	PUNCT
cet-15443	28	3	in	in	ADP
cet-15443	28	4	this	this	DET
cet-15443	28	5	work	work	NOUN
cet-15443	28	6	,	,	PUNCT
cet-15443	28	7	a	a	DET
cet-15443	28	8	mathematical	mathematical	ADJ
cet-15443	28	9	model	model	NOUN
cet-15443	28	10	previously	previously	ADV
cet-15443	28	11	developed	develop	VERB
cet-15443	28	12	(	(	PUNCT
cet-15443	28	13	gérard	gérard	NOUN
cet-15443	28	14	and	and	CCONJ
cet-15443	28	15	golbeter	golbeter	NOUN
cet-15443	28	16	,	,	PUNCT
cet-15443	28	17	2009	2009	NUM
cet-15443	28	18	,	,	PUNCT
cet-15443	28	19	2012	2012	NUM
cet-15443	28	20	,	,	PUNCT
cet-15443	28	21	2014	2014	NUM
cet-15443	28	22	)	)	PUNCT
cet-15443	28	23	was	be	AUX
cet-15443	28	24	used	use	VERB
cet-15443	28	25	to	to	PART
cet-15443	28	26	quantify	quantify	VERB
cet-15443	28	27	the	the	DET
cet-15443	28	28	effect	effect	NOUN
cet-15443	28	29	of	of	ADP
cet-15443	28	30	the	the	DET
cet-15443	28	31	proteins	protein	NOUN
cet-15443	28	32	p21	p21	NOUN
cet-15443	28	33	/	/	SYM
cet-15443	28	34	p27	p27	PROPN
cet-15443	28	35	basal	basal	NOUN
cet-15443	28	36	production	production	NOUN
cet-15443	28	37	rate	rate	NOUN
cet-15443	28	38	on	on	ADP
cet-15443	28	39	the	the	DET
cet-15443	28	40	cell	cell	NOUN
cet-15443	28	41	cycle	cycle	NOUN
cet-15443	28	42	dynamics	dynamic	NOUN
cet-15443	28	43	,	,	PUNCT
cet-15443	28	44	i.e.	i.e.	X
cet-15443	28	45	mirroring	mirror	VERB
cet-15443	28	46	microgravity	microgravity	NOUN
cet-15443	28	47	conditions	condition	NOUN
cet-15443	28	48	.	.	PUNCT
cet-15443	29	1	the	the	DET
cet-15443	29	2	duplication	duplication	NOUN
cet-15443	29	3	time	time	NOUN
cet-15443	29	4	is	be	AUX
cet-15443	29	5	determined	determine	VERB
cet-15443	29	6	from	from	ADP
cet-15443	29	7	the	the	DET
cet-15443	29	8	dynamics	dynamic	NOUN
cet-15443	29	9	of	of	ADP
cet-15443	29	10	cyclin	cyclin	PROPN
cet-15443	29	11	/	/	SYM
cet-15443	29	12	cdk	cdk	PROPN
cet-15443	29	13	complex	complex	ADJ
cet-15443	29	14	formation	formation	NOUN
cet-15443	29	15	reflecting	reflect	VERB
cet-15443	29	16	the	the	DET
cet-15443	29	17	temporal	temporal	ADJ
cet-15443	29	18	progression	progression	NOUN
cet-15443	29	19	of	of	ADP
cet-15443	29	20	the	the	DET
cet-15443	29	21	cell	cell	NOUN
cet-15443	29	22	cycle	cycle	NOUN
cet-15443	29	23	phases	phase	NOUN
cet-15443	29	24	.	.	PUNCT
cet-15443	30	1	in	in	ADP
cet-15443	30	2	presence	presence	NOUN
cet-15443	30	3	of	of	ADP
cet-15443	30	4	a	a	DET
cet-15443	30	5	p21	p21	NOUN
cet-15443	30	6	overexpression	overexpression	NOUN
cet-15443	30	7	,	,	PUNCT
cet-15443	30	8	duplication	duplication	NOUN
cet-15443	30	9	time	time	NOUN
cet-15443	30	10	is	be	AUX
cet-15443	30	11	lengthened	lengthen	VERB
cet-15443	30	12	and	and	CCONJ
cet-15443	30	13	abnormalities	abnormality	NOUN
cet-15443	30	14	such	such	ADJ
cet-15443	30	15	as	as	ADP
cet-15443	30	16	biperiodic	biperiodic	ADJ
cet-15443	30	17	duplication	duplication	NOUN
cet-15443	30	18	,	,	PUNCT
cet-15443	30	19	endoreplication	endoreplication	NOUN
cet-15443	30	20	or	or	CCONJ
cet-15443	30	21	tetraploidy	tetraploidy	ADJ
cet-15443	30	22	,	,	PUNCT
cet-15443	30	23	as	as	ADV
cet-15443	30	24	well	well	ADV
cet-15443	30	25	as	as	ADP
cet-15443	30	26	cessation	cessation	NOUN
cet-15443	30	27	of	of	ADP
cet-15443	30	28	cell	cell	NOUN
cet-15443	30	29	replication	replication	NOUN
cet-15443	30	30	may	may	AUX
cet-15443	30	31	occur	occur	VERB
cet-15443	30	32	.	.	PUNCT
cet-15443	31	1	2	2	X
cet-15443	31	2	.	.	X
cet-15443	31	3	mathematical	mathematical	ADJ
cet-15443	31	4	model	model	NOUN
cet-15443	31	5	the	the	DET
cet-15443	31	6	kinetic	kinetic	ADJ
cet-15443	31	7	model	model	NOUN
cet-15443	31	8	used	use	VERB
cet-15443	31	9	for	for	ADP
cet-15443	31	10	the	the	DET
cet-15443	31	11	description	description	NOUN
cet-15443	31	12	of	of	ADP
cet-15443	31	13	the	the	DET
cet-15443	31	14	complex	complex	ADJ
cet-15443	31	15	network	network	NOUN
cet-15443	31	16	of	of	ADP
cet-15443	31	17	biochemical	biochemical	ADJ
cet-15443	31	18	reactions	reaction	NOUN
cet-15443	31	19	that	that	PRON
cet-15443	31	20	governs	govern	VERB
cet-15443	31	21	the	the	DET
cet-15443	31	22	cell	cell	NOUN
cet-15443	31	23	cycle	cycle	NOUN
cet-15443	31	24	phases	phase	NOUN
cet-15443	31	25	were	be	AUX
cet-15443	31	26	developed	develop	VERB
cet-15443	31	27	and	and	CCONJ
cet-15443	31	28	proposed	propose	VERB
cet-15443	31	29	by	by	ADP
cet-15443	31	30	gérard	gérard	PROPN
cet-15443	31	31	and	and	CCONJ
cet-15443	31	32	goldbeter	goldbeter	PROPN
cet-15443	31	33	(	(	PUNCT
cet-15443	31	34	2014	2014	NUM
cet-15443	31	35	)	)	PUNCT
cet-15443	31	36	.	.	PUNCT
cet-15443	32	1	a	a	DET
cet-15443	32	2	schematic	schematic	ADJ
cet-15443	32	3	of	of	ADP
cet-15443	32	4	the	the	DET
cet-15443	32	5	complex	complex	ADJ
cet-15443	32	6	model	model	NOUN
cet-15443	32	7	including	include	VERB
cet-15443	32	8	a	a	DET
cet-15443	32	9	series	series	NOUN
cet-15443	32	10	of	of	ADP
cet-15443	32	11	biological	biological	ADJ
cet-15443	32	12	reactions	reaction	NOUN
cet-15443	32	13	is	be	AUX
cet-15443	32	14	shown	show	VERB
cet-15443	32	15	in	in	ADP
cet-15443	32	16	figure	figure	NOUN
cet-15443	32	17	2	2	NUM
cet-15443	32	18	.	.	PUNCT
cet-15443	33	1	this	this	DET
cet-15443	33	2	model	model	NOUN
cet-15443	33	3	describes	describe	VERB
cet-15443	33	4	the	the	DET
cet-15443	33	5	activation	activation	NOUN
cet-15443	33	6	dynamics	dynamic	NOUN
cet-15443	33	7	of	of	ADP
cet-15443	33	8	specific	specific	ADJ
cet-15443	33	9	cyclin	cyclin	PROPN
cet-15443	33	10	/	/	SYM
cet-15443	33	11	cdk	cdk	PROPN
cet-15443	33	12	complex	complex	PROPN
cet-15443	33	13	md	md	PROPN
cet-15443	33	14	,	,	PUNCT
cet-15443	33	15	me	i	PRON
cet-15443	33	16	,	,	PUNCT
cet-15443	33	17	ma	ma	PROPN
cet-15443	33	18	and	and	CCONJ
cet-15443	33	19	mb	mb	PROPN
cet-15443	33	20	(	(	PUNCT
cet-15443	33	21	cyclin	cyclin	PROPN
cet-15443	33	22	d	d	PROPN
cet-15443	33	23	/	/	SYM
cet-15443	33	24	ckd4	ckd4	PROPN
cet-15443	33	25	-	-	PUNCT
cet-15443	33	26	6	6	NUM
cet-15443	33	27	,	,	PUNCT
cet-15443	33	28	cyclin	cyclin	NOUN
cet-15443	33	29	e	e	PROPN
cet-15443	33	30	/	/	SYM
cet-15443	33	31	cdk2	cdk2	PROPN
cet-15443	33	32	,	,	PUNCT
cet-15443	33	33	cyclin	cyclin	PROPN
cet-15443	33	34	a	a	PRON
cet-15443	33	35	/	/	SYM
cet-15443	33	36	cdk2	cdk2	PROPN
cet-15443	33	37	and	and	CCONJ
cet-15443	33	38	cyclin	cyclin	PROPN
cet-15443	33	39	b	b	PROPN
cet-15443	33	40	/	/	SYM
cet-15443	33	41	cdk1	cdk1	PROPN
cet-15443	33	42	,	,	PUNCT
cet-15443	33	43	respectively	respectively	ADV
cet-15443	33	44	)	)	PUNCT
cet-15443	33	45	,	,	PUNCT
cet-15443	33	46	whose	whose	DET
cet-15443	33	47	temporal	temporal	ADJ
cet-15443	33	48	maxima	maxima	NOUN
cet-15443	33	49	and	and	CCONJ
cet-15443	33	50	minima	minima	PROPN
cet-15443	33	51	mark	mark	NOUN
cet-15443	33	52	the	the	DET
cet-15443	33	53	progression	progression	NOUN
cet-15443	33	54	of	of	ADP
cet-15443	33	55	the	the	DET
cet-15443	33	56	different	different	ADJ
cet-15443	33	57	phases	phase	NOUN
cet-15443	33	58	in	in	ADP
cet-15443	33	59	the	the	DET
cet-15443	33	60	cell	cell	NOUN
cet-15443	33	61	cycle	cycle	NOUN
cet-15443	33	62	.	.	PUNCT
cet-15443	34	1	also	also	ADV
cet-15443	34	2	,	,	PUNCT
cet-15443	34	3	the	the	DET
cet-15443	34	4	model	model	NOUN
cet-15443	34	5	describes	describe	VERB
cet-15443	34	6	the	the	DET
cet-15443	34	7	regulatory	regulatory	ADJ
cet-15443	34	8	effect	effect	NOUN
cet-15443	34	9	of	of	ADP
cet-15443	34	10	cdh1	cdh1	PROPN
cet-15443	34	11	,	,	PUNCT
cet-15443	34	12	cdc20	cdc20	PROPN
cet-15443	34	13	,	,	PUNCT
cet-15443	34	14	wee1	wee1	NOUN
cet-15443	34	15	,	,	PUNCT
cet-15443	34	16	skp2	skp2	ADJ
cet-15443	34	17	and	and	CCONJ
cet-15443	34	18	cdc25	cdc25	ADJ
cet-15443	34	19	phosphatase	phosphatase	NOUN
cet-15443	34	20	proteins	protein	NOUN
cet-15443	34	21	and	and	CCONJ
cet-15443	34	22	complex	complex	ADJ
cet-15443	34	23	inhibitors	inhibitor	NOUN
cet-15443	34	24	(	(	PUNCT
cet-15443	34	25	p21	p21	NOUN
cet-15443	34	26	/	/	SYM
cet-15443	34	27	p27	p27	PROPN
cet-15443	34	28	)	)	PUNCT
cet-15443	34	29	,	,	PUNCT
cet-15443	34	30	the	the	DET
cet-15443	34	31	synthesis	synthesis	NOUN
cet-15443	34	32	and	and	CCONJ
cet-15443	34	33	degradation	degradation	NOUN
cet-15443	34	34	of	of	ADP
cet-15443	34	35	cyclins	cyclin	NOUN
cet-15443	34	36	,	,	PUNCT
cet-15443	34	37	their	their	PRON
cet-15443	34	38	binding	bind	VERB
cet-15443	34	39	with	with	ADP
cet-15443	34	40	complexes	complex	NOUN
cet-15443	34	41	,	,	PUNCT
cet-15443	34	42	and	and	CCONJ
cet-15443	34	43	the	the	DET
cet-15443	34	44	opposed	opposed	ADJ
cet-15443	34	45	effect	effect	NOUN
cet-15443	34	46	of	of	ADP
cet-15443	34	47	the	the	DET
cet-15443	34	48	tumour	tumour	NOUN
cet-15443	34	49	suppressor	suppressor	NOUN
cet-15443	34	50	prb	prb	NOUN
cet-15443	34	51	and	and	CCONJ
cet-15443	34	52	the	the	DET
cet-15443	34	53	transcription	transcription	NOUN
cet-15443	34	54	factor	factor	NOUN
cet-15443	34	55	e2f	e2f	PROPN
cet-15443	34	56	.	.	PUNCT
cet-15443	35	1	it	it	PRON
cet-15443	35	2	also	also	ADV
cet-15443	35	3	incorporates	incorporate	VERB
cet-15443	35	4	the	the	DET
cet-15443	35	5	positive	positive	ADJ
cet-15443	35	6	influence	influence	NOUN
cet-15443	35	7	of	of	ADP
cet-15443	35	8	external	external	ADJ
cet-15443	35	9	growth	growth	NOUN
cet-15443	35	10	factors	factor	NOUN
cet-15443	35	11	gf	gf	NOUN
cet-15443	35	12	,	,	PUNCT
cet-15443	35	13	signalling	signal	VERB
cet-15443	35	14	from	from	ADP
cet-15443	35	15	the	the	DET
cet-15443	35	16	extracellular	extracellular	ADJ
cet-15443	35	17	matrix	matrix	NOUN
cet-15443	35	18	ecm	ecm	NOUN
cet-15443	35	19	and	and	CCONJ
cet-15443	35	20	accounts	account	NOUN
cet-15443	35	21	for	for	ADP
cet-15443	35	22	the	the	DET
cet-15443	35	23	reduction	reduction	NOUN
cet-15443	35	24	in	in	ADP
cet-15443	35	25	proliferation	proliferation	NOUN
cet-15443	35	26	rate	rate	NOUN
cet-15443	35	27	related	relate	VERB
cet-15443	35	28	to	to	ADP
cet-15443	35	29	contact	contact	NOUN
cet-15443	35	30	inhibition	inhibition	NOUN
cet-15443	35	31	.	.	PUNCT
cet-15443	36	1	the	the	DET
cet-15443	36	2	mathematical	mathematical	ADJ
cet-15443	36	3	model	model	NOUN
cet-15443	36	4	includes	include	VERB
cet-15443	36	5	a	a	DET
cet-15443	36	6	system	system	NOUN
cet-15443	36	7	of	of	ADP
cet-15443	36	8	42	42	NUM
cet-15443	36	9	ordinary	ordinary	ADJ
cet-15443	36	10	differential	differential	ADJ
cet-15443	36	11	equations	equation	NOUN
cet-15443	36	12	(	(	PUNCT
cet-15443	36	13	odes	ode	NOUN
cet-15443	36	14	)	)	PUNCT
cet-15443	36	15	with	with	ADP
cet-15443	36	16	the	the	DET
cet-15443	36	17	following	follow	VERB
cet-15443	36	18	form	form	NOUN
cet-15443	36	19	:	:	PUNCT
cet-15443	36	20	dc	dc	PROPN
cet-15443	36	21	dt	dt	X
cet-15443	36	22	=	=	SYM
cet-15443	36	23	𝑣𝑏	𝑣𝑏	PROPN
cet-15443	36	24	+	+	CCONJ
cet-15443	36	25	∑	∑	AUX
cet-15443	36	26	𝑟𝑝𝑟𝑜	𝑟𝑝𝑟𝑜	PROPN
cet-15443	36	27	−	−	NUM
cet-15443	36	28	∑	∑	NOUN
cet-15443	36	29	𝑟𝑖𝑛ℎ𝑖	𝑟𝑖𝑛ℎ𝑖	VERB
cet-15443	36	30	−	−	PROPN
cet-15443	36	31	𝑘𝑑𝐶	𝑘𝑑𝐶	PROPN
cet-15443	36	32	(	(	PUNCT
cet-15443	36	33	1	1	NUM
cet-15443	36	34	)	)	PUNCT
cet-15443	36	35	here	here	ADV
cet-15443	36	36	,	,	PUNCT
cet-15443	36	37	the	the	DET
cet-15443	36	38	generic	generic	ADJ
cet-15443	36	39	specie	specie	NOUN
cet-15443	36	40	c	c	PROPN
cet-15443	36	41	is	be	AUX
cet-15443	36	42	formed	form	VERB
cet-15443	36	43	by	by	ADP
cet-15443	36	44	an	an	DET
cet-15443	36	45	interplay	interplay	NOUN
cet-15443	36	46	among	among	ADP
cet-15443	36	47	a	a	DET
cet-15443	36	48	basal	basal	ADJ
cet-15443	36	49	production	production	NOUN
cet-15443	36	50	rate	rate	NOUN
cet-15443	36	51	(	(	PUNCT
cet-15443	36	52	𝑣𝑏	𝑣𝑏	NOUN
cet-15443	36	53	)	)	PUNCT
cet-15443	36	54	,	,	PUNCT
cet-15443	36	55	reaction	reaction	NOUN
cet-15443	36	56	rates	rate	NOUN
cet-15443	36	57	related	relate	VERB
cet-15443	36	58	to	to	ADP
cet-15443	36	59	stimulatory	stimulatory	NOUN
cet-15443	36	60	(	(	PUNCT
cet-15443	36	61	𝑟𝑝𝑟𝑜	𝑟𝑝𝑟𝑜	PROPN
cet-15443	36	62	)	)	PUNCT
cet-15443	36	63	and	and	CCONJ
cet-15443	36	64	(	(	PUNCT
cet-15443	36	65	𝑟𝑖𝑛ℎ𝑖	𝑟𝑖𝑛ℎ𝑖	NOUN
cet-15443	36	66	)	)	PUNCT
cet-15443	36	67	inhibitory	inhibitory	ADJ
cet-15443	36	68	effects	effect	NOUN
cet-15443	36	69	,	,	PUNCT
cet-15443	36	70	and	and	CCONJ
cet-15443	36	71	degradation	degradation	NOUN
cet-15443	36	72	(	(	PUNCT
cet-15443	36	73	𝑘𝑑𝐶	𝑘𝑑𝐶	PROPN
cet-15443	36	74	)	)	PUNCT
cet-15443	36	75	.	.	PUNCT
cet-15443	37	1	the	the	DET
cet-15443	37	2	chemical	chemical	NOUN
cet-15443	37	3	kinetics	kinetic	NOUN
cet-15443	37	4	are	be	AUX
cet-15443	37	5	defined	define	VERB
cet-15443	37	6	using	use	VERB
cet-15443	37	7	power	power	NOUN
cet-15443	37	8	-	-	PUNCT
cet-15443	37	9	law	law	NOUN
cet-15443	37	10	or	or	CCONJ
cet-15443	37	11	michaelis	michaeli	NOUN
cet-15443	37	12	-	-	PUNCT
cet-15443	37	13	menten	menten	ADJ
cet-15443	37	14	relationships	relationship	NOUN
cet-15443	37	15	depending	depend	VERB
cet-15443	37	16	on	on	ADP
cet-15443	37	17	the	the	DET
cet-15443	37	18	type	type	NOUN
cet-15443	37	19	of	of	ADP
cet-15443	37	20	interaction	interaction	NOUN
cet-15443	37	21	.	.	PUNCT
cet-15443	38	1	the	the	DET
cet-15443	38	2	model	model	NOUN
cet-15443	38	3	equations	equation	NOUN
cet-15443	38	4	and	and	CCONJ
cet-15443	38	5	parameters	parameter	NOUN
cet-15443	38	6	are	be	AUX
cet-15443	38	7	taken	take	VERB
cet-15443	38	8	from	from	ADP
cet-15443	38	9	the	the	DET
cet-15443	38	10	original	original	ADJ
cet-15443	38	11	work	work	NOUN
cet-15443	38	12	by	by	ADP
cet-15443	38	13	gérard	gérard	PROPN
cet-15443	38	14	and	and	CCONJ
cet-15443	38	15	goldbeter	goldbeter	PROPN
cet-15443	38	16	(	(	PUNCT
cet-15443	38	17	2014	2014	NUM
cet-15443	38	18	)	)	PUNCT
cet-15443	38	19	and	and	CCONJ
cet-15443	38	20	are	be	AUX
cet-15443	38	21	not	not	PART
cet-15443	38	22	reported	report	VERB
cet-15443	38	23	in	in	ADP
cet-15443	38	24	this	this	DET
cet-15443	38	25	work	work	NOUN
cet-15443	38	26	for	for	ADP
cet-15443	38	27	the	the	DET
cet-15443	38	28	sake	sake	NOUN
cet-15443	38	29	of	of	ADP
cet-15443	38	30	brevity	brevity	NOUN
cet-15443	38	31	.	.	PUNCT
cet-15443	39	1	in	in	ADP
cet-15443	39	2	this	this	DET
cet-15443	39	3	work	work	NOUN
cet-15443	39	4	,	,	PUNCT
cet-15443	39	5	the	the	DET
cet-15443	39	6	model	model	NOUN
cet-15443	39	7	was	be	AUX
cet-15443	39	8	used	use	VERB
cet-15443	39	9	to	to	PART
cet-15443	39	10	analyse	analyse	VERB
cet-15443	39	11	the	the	DET
cet-15443	39	12	effect	effect	NOUN
cet-15443	39	13	of	of	ADP
cet-15443	39	14	inhibitor	inhibitor	NOUN
cet-15443	39	15	proteins	protein	NOUN
cet-15443	39	16	p21	p21	NOUN
cet-15443	39	17	and	and	CCONJ
cet-15443	39	18	p27	p27	NOUN
cet-15443	39	19	on	on	ADP
cet-15443	39	20	the	the	DET
cet-15443	39	21	active	active	ADJ
cet-15443	39	22	md	md	PROPN
cet-15443	39	23	,	,	PUNCT
cet-15443	39	24	me	i	PRON
cet-15443	39	25	,	,	PUNCT
cet-15443	39	26	ma	ma	PROPN
cet-15443	39	27	,	,	PUNCT
cet-15443	39	28	mb	mb	ADP
cet-15443	39	29	complexes	complex	NOUN
cet-15443	39	30	and	and	CCONJ
cet-15443	39	31	assess	assess	VERB
cet-15443	39	32	the	the	DET
cet-15443	39	33	impact	impact	NOUN
cet-15443	39	34	on	on	ADP
cet-15443	39	35	the	the	DET
cet-15443	39	36	cell	cell	NOUN
cet-15443	39	37	cycle	cycle	NOUN
cet-15443	39	38	phases	phase	NOUN
cet-15443	39	39	.	.	PUNCT
cet-15443	40	1	to	to	PART
cet-15443	40	2	simulate	simulate	VERB
cet-15443	40	3	the	the	DET
cet-15443	40	4	effects	effect	NOUN
cet-15443	40	5	of	of	ADP
cet-15443	40	6	p21	p21	NOUN
cet-15443	40	7	gene	gene	NOUN
cet-15443	40	8	overexpression	overexpression	NOUN
cet-15443	40	9	observed	observe	VERB
cet-15443	40	10	under	under	ADP
cet-15443	40	11	microgravity	microgravity	NOUN
cet-15443	40	12	conditions	condition	NOUN
cet-15443	40	13	(	(	PUNCT
cet-15443	40	14	coinu	coinu	NOUN
cet-15443	40	15	et	et	NOUN
cet-15443	40	16	al	al	PROPN
cet-15443	40	17	.	.	PROPN
cet-15443	40	18	2006	2006	NUM
cet-15443	40	19	)	)	PUNCT
cet-15443	40	20	,	,	PUNCT
cet-15443	40	21	model	model	NOUN
cet-15443	40	22	simulations	simulation	NOUN
cet-15443	40	23	were	be	AUX
cet-15443	40	24	performed	perform	VERB
cet-15443	40	25	for	for	ADP
cet-15443	40	26	different	different	ADJ
cet-15443	40	27	𝑣𝑠1𝑝27	𝑣𝑠1𝑝27	ADJ
cet-15443	40	28	parameter	parameter	NOUN
cet-15443	40	29	values	value	NOUN
cet-15443	40	30	representing	represent	VERB
cet-15443	40	31	the	the	DET
cet-15443	40	32	basal	basal	ADJ
cet-15443	40	33	production	production	NOUN
cet-15443	40	34	rate	rate	NOUN
cet-15443	40	35	of	of	ADP
cet-15443	40	36	inhibitor	inhibitor	NOUN
cet-15443	40	37	proteins	protein	NOUN
cet-15443	40	38	p21	p21	NOUN
cet-15443	40	39	and	and	CCONJ
cet-15443	40	40	p27	p27	NOUN
cet-15443	40	41	.	.	PUNCT
cet-15443	41	1	1154	1154	NUM
cet-15443	41	2	figure	figure	NOUN
cet-15443	41	3	2	2	NUM
cet-15443	41	4	.	.	PUNCT
cet-15443	41	5	cyclin	cyclin	NOUN
cet-15443	41	6	/	/	SYM
cet-15443	41	7	cdk	cdk	PROPN
cet-15443	41	8	network	network	PROPN
cet-15443	41	9	kinetic	kinetic	PROPN
cet-15443	41	10	model	model	NOUN
cet-15443	41	11	driving	drive	VERB
cet-15443	41	12	the	the	DET
cet-15443	41	13	mammalian	mammalian	ADJ
cet-15443	41	14	cell	cell	NOUN
cet-15443	41	15	cycle	cycle	NOUN
cet-15443	41	16	(	(	PUNCT
cet-15443	41	17	gerard	gerard	NOUN
cet-15443	41	18	and	and	CCONJ
cet-15443	41	19	goldbeter	goldbeter	PROPN
cet-15443	41	20	,	,	PUNCT
cet-15443	41	21	2014	2014	NUM
cet-15443	41	22	)	)	PUNCT
cet-15443	41	23	.	.	PUNCT
cet-15443	42	1	more	more	ADV
cet-15443	42	2	specifically	specifically	ADV
cet-15443	42	3	,	,	PUNCT
cet-15443	42	4	it	it	PRON
cet-15443	42	5	was	be	AUX
cet-15443	42	6	assumed	assume	VERB
cet-15443	42	7	that	that	SCONJ
cet-15443	42	8	adjustment	adjustment	NOUN
cet-15443	42	9	of	of	ADP
cet-15443	42	10	the	the	DET
cet-15443	42	11	cell	cell	NOUN
cet-15443	42	12	culture	culture	NOUN
cet-15443	42	13	to	to	ADP
cet-15443	42	14	microgravity	microgravity	NOUN
cet-15443	42	15	condition	condition	NOUN
cet-15443	42	16	occurs	occur	VERB
cet-15443	42	17	during	during	ADP
cet-15443	42	18	a	a	DET
cet-15443	42	19	time	time	NOUN
cet-15443	42	20	frame	frame	NOUN
cet-15443	42	21	of	of	ADP
cet-15443	42	22	24	24	NUM
cet-15443	42	23	h.	h.	PROPN
cet-15443	42	24	thus	thus	ADV
cet-15443	42	25	,	,	PUNCT
cet-15443	42	26	the	the	DET
cet-15443	42	27	𝑣𝑠1𝑝27	𝑣𝑠1𝑝27	ADJ
cet-15443	42	28	parameter	parameter	NOUN
cet-15443	42	29	was	be	AUX
cet-15443	42	30	simulated	simulate	VERB
cet-15443	42	31	as	as	ADP
cet-15443	42	32	increasing	increase	VERB
cet-15443	42	33	linearly	linearly	ADV
cet-15443	42	34	in	in	ADP
cet-15443	42	35	time	time	NOUN
cet-15443	42	36	during	during	ADP
cet-15443	42	37	the	the	DET
cet-15443	42	38	first	first	ADJ
cet-15443	42	39	24	24	NUM
cet-15443	42	40	h	h	NOUN
cet-15443	42	41	up	up	ADP
cet-15443	42	42	to	to	ADP
cet-15443	42	43	a	a	DET
cet-15443	42	44	maximum	maximum	ADJ
cet-15443	42	45	value	value	NOUN
cet-15443	42	46	and	and	CCONJ
cet-15443	42	47	then	then	ADV
cet-15443	42	48	kept	keep	VERB
cet-15443	42	49	fixed	fix	VERB
cet-15443	42	50	for	for	ADP
cet-15443	42	51	later	later	ADJ
cet-15443	42	52	times	time	NOUN
cet-15443	42	53	,	,	PUNCT
cet-15443	42	54	according	accord	VERB
cet-15443	42	55	to	to	ADP
cet-15443	42	56	the	the	DET
cet-15443	42	57	following	follow	VERB
cet-15443	42	58	relationship	relationship	NOUN
cet-15443	42	59	:	:	PUNCT
cet-15443	42	60	𝑣𝑠1𝑝27	𝑣𝑠1𝑝27	PROPN
cet-15443	42	61	[	[	PUNCT
cet-15443	42	62	µ𝑀	µ𝑀	NOUN
cet-15443	42	63	ℎ	ℎ	X
cet-15443	42	64	]	]	X
cet-15443	42	65	=	=	SYM
cet-15443	42	66	0.8	0.8	NUM
cet-15443	42	67	+	+	CCONJ
cet-15443	42	68	(	(	PUNCT
cet-15443	42	69	𝑣𝑠1𝑝27	𝑣𝑠1𝑝27	ADJ
cet-15443	42	70	𝑚𝑎𝑥	𝑚𝑎𝑥	NOUN
cet-15443	42	71	−0.8	−0.8	ADJ
cet-15443	42	72	)	)	PUNCT
cet-15443	42	73	24	24	NUM
cet-15443	42	74	ℎ	ℎ	PROPN
cet-15443	42	75	𝑡	𝑡	VERB
cet-15443	42	76	𝑡	𝑡	X
cet-15443	42	77	<	<	X
cet-15443	42	78	24ℎ	24ℎ	NOUN
cet-15443	42	79	(	(	PUNCT
cet-15443	42	80	2	2	X
cet-15443	42	81	)	)	PUNCT
cet-15443	42	82	𝑣𝑠1𝑝27	𝑣𝑠1𝑝27	PROPN
cet-15443	42	83	[	[	PUNCT
cet-15443	42	84	µ𝑀	µ𝑀	NOUN
cet-15443	42	85	ℎ	ℎ	X
cet-15443	42	86	]	]	PUNCT
cet-15443	42	87	=	=	PUNCT
cet-15443	42	88	𝑣𝑠1𝑝27	𝑣𝑠1𝑝27	NUM
cet-15443	42	89	𝑚𝑎𝑥	𝑚𝑎𝑥	ADJ
cet-15443	42	90	𝑡	𝑡	X
cet-15443	42	91	≥	≥	PROPN
cet-15443	42	92	24ℎ	24ℎ	NOUN
cet-15443	42	93	(	(	PUNCT
cet-15443	42	94	3	3	NUM
cet-15443	42	95	)	)	PUNCT
cet-15443	42	96	where	where	SCONJ
cet-15443	42	97	𝑣𝑠1𝑝27	𝑣𝑠1𝑝27	ADJ
cet-15443	42	98	𝑚𝑎𝑥	𝑚𝑎𝑥	ADJ
cet-15443	42	99	parameter	parameter	NOUN
cet-15443	42	100	indicates	indicate	VERB
cet-15443	42	101	the	the	DET
cet-15443	42	102	maximal	maximal	ADJ
cet-15443	42	103	value	value	NOUN
cet-15443	42	104	of	of	ADP
cet-15443	42	105	𝑣𝑠1𝑝27	𝑣𝑠1𝑝27	PROPN
cet-15443	42	106	corresponding	correspond	VERB
cet-15443	42	107	to	to	ADP
cet-15443	42	108	the	the	DET
cet-15443	42	109	p21	p21	NOUN
cet-15443	42	110	overexpression	overexpression	NOUN
cet-15443	42	111	.	.	PUNCT
cet-15443	43	1	3	3	X
cet-15443	43	2	.	.	NOUN
cet-15443	43	3	results	result	NOUN
cet-15443	43	4	and	and	CCONJ
cet-15443	43	5	discussions	discussion	NOUN
cet-15443	43	6	model	model	NOUN
cet-15443	43	7	simulations	simulation	NOUN
cet-15443	43	8	are	be	AUX
cet-15443	43	9	performed	perform	VERB
cet-15443	43	10	by	by	ADP
cet-15443	43	11	integrating	integrate	VERB
cet-15443	43	12	a	a	DET
cet-15443	43	13	system	system	NOUN
cet-15443	43	14	of	of	ADP
cet-15443	43	15	42	42	NUM
cet-15443	43	16	odes	ode	NOUN
cet-15443	43	17	as	as	ADP
cet-15443	43	18	an	an	DET
cet-15443	43	19	initial	initial	ADJ
cet-15443	43	20	value	value	NOUN
cet-15443	43	21	problem	problem	NOUN
cet-15443	43	22	using	use	VERB
cet-15443	43	23	fortran	fortran	ADJ
cet-15443	43	24	standard	standard	PROPN
cet-15443	43	25	numerical	numerical	PROPN
cet-15443	43	26	libraries	library	NOUN
cet-15443	43	27	based	base	VERB
cet-15443	43	28	on	on	ADP
cet-15443	43	29	gear	gear	NOUN
cet-15443	43	30	method	method	NOUN
cet-15443	43	31	(	(	PUNCT
cet-15443	43	32	imsl	imsl	NOUN
cet-15443	43	33	)	)	PUNCT
cet-15443	43	34	.	.	PUNCT
cet-15443	44	1	the	the	DET
cet-15443	44	2	effect	effect	NOUN
cet-15443	44	3	of	of	ADP
cet-15443	44	4	𝑣𝑠1𝑝27	𝑣𝑠1𝑝27	ADJ
cet-15443	44	5	parameter	parameter	NOUN
cet-15443	44	6	on	on	ADP
cet-15443	44	7	the	the	DET
cet-15443	44	8	cell	cell	NOUN
cet-15443	44	9	cycle	cycle	NOUN
cet-15443	44	10	progression	progression	NOUN
cet-15443	44	11	was	be	AUX
cet-15443	44	12	investigated	investigate	VERB
cet-15443	44	13	for	for	ADP
cet-15443	44	14	different	different	ADJ
cet-15443	44	15	scenarios	scenario	NOUN
cet-15443	44	16	as	as	SCONJ
cet-15443	44	17	reported	report	VERB
cet-15443	44	18	in	in	ADP
cet-15443	44	19	table	table	NOUN
cet-15443	44	20	1	1	NUM
cet-15443	44	21	.	.	PUNCT
cet-15443	45	1	the	the	DET
cet-15443	45	2	𝑣𝑠1𝑝27	𝑣𝑠1𝑝27	ADJ
cet-15443	45	3	𝑚𝑎𝑥	𝑚𝑎𝑥	ADJ
cet-15443	45	4	value	value	NOUN
cet-15443	45	5	used	use	VERB
cet-15443	45	6	for	for	ADP
cet-15443	45	7	the	the	DET
cet-15443	45	8	base	base	NOUN
cet-15443	45	9	case	case	NOUN
cet-15443	45	10	corresponds	correspond	VERB
cet-15443	45	11	to	to	ADP
cet-15443	45	12	the	the	DET
cet-15443	45	13	homeostatic	homeostatic	ADJ
cet-15443	45	14	conditions	condition	NOUN
cet-15443	45	15	under	under	ADP
cet-15443	45	16	normal	normal	ADJ
cet-15443	45	17	gravity	gravity	NOUN
cet-15443	45	18	on	on	ADP
cet-15443	45	19	earth	earth	NOUN
cet-15443	45	20	.	.	PUNCT
cet-15443	46	1	table	table	NOUN
cet-15443	46	2	1	1	NUM
cet-15443	46	3	:	:	PUNCT
cet-15443	46	4	the	the	DET
cet-15443	46	5	duplication	duplication	NOUN
cet-15443	46	6	time	time	NOUN
cet-15443	46	7	(	(	PUNCT
cet-15443	46	8	𝑡𝐷	𝑡𝐷	NOUN
cet-15443	46	9	)	)	PUNCT
cet-15443	46	10	obtained	obtain	VERB
cet-15443	46	11	for	for	ADP
cet-15443	46	12	different	different	ADJ
cet-15443	46	13	𝑣𝑠1𝑝27	𝑣𝑠1𝑝27	ADJ
cet-15443	46	14	value	value	NOUN
cet-15443	46	15	to	to	PART
cet-15443	46	16	simulate	simulate	VERB
cet-15443	46	17	normoand	normoand	PROPN
cet-15443	46	18	micro	micro	NOUN
cet-15443	46	19	-	-	NOUN
cet-15443	46	20	gravity	gravity	NOUN
cet-15443	46	21	.	.	PUNCT
cet-15443	47	1	gravity	gravity	NOUN
cet-15443	47	2	earth	earth	NOUN
cet-15443	47	3	microgravity	microgravity	NOUN
cet-15443	47	4	base	base	NOUN
cet-15443	47	5	case	case	NOUN
cet-15443	47	6	case	case	NOUN
cet-15443	47	7	1	1	NUM
cet-15443	47	8	case	case	NOUN
cet-15443	47	9	2	2	NUM
cet-15443	47	10	case3	case3	NOUN
cet-15443	47	11	𝑣𝑠1𝑝27	𝑣𝑠1𝑝27	ADJ
cet-15443	47	12	𝑚𝑎𝑥	𝑚𝑎𝑥	NOUN
cet-15443	47	13	[	[	PUNCT
cet-15443	47	14	µ𝑀	µ𝑀	DET
cet-15443	47	15	ℎ	ℎ	X
cet-15443	47	16	]	]	PUNCT
cet-15443	47	17	0.8	0.8	NUM
cet-15443	47	18	2.4	2.4	NUM
cet-15443	47	19	3.6	3.6	NUM
cet-15443	47	20	4.8	4.8	NUM
cet-15443	47	21	𝑡𝐷	𝑡𝐷	PROPN
cet-15443	48	1	[	[	X
cet-15443	48	2	ℎ	ℎ	X
cet-15443	48	3	]	]	X
cet-15443	48	4	24	24	NUM
cet-15443	48	5	32	32	NUM
cet-15443	48	6	and	and	CCONJ
cet-15443	48	7	52	52	NUM
cet-15443	48	8	97	97	NUM
cet-15443	48	9	cell	cell	NOUN
cet-15443	48	10	cycle	cycle	NOUN
cet-15443	48	11	arrest	arrest	NOUN
cet-15443	48	12	3.1	3.1	NUM
cet-15443	48	13	base	base	NOUN
cet-15443	48	14	case	case	NOUN
cet-15443	48	15	the	the	DET
cet-15443	48	16	cell	cell	NOUN
cet-15443	48	17	duplication	duplication	NOUN
cet-15443	48	18	occurs	occur	VERB
cet-15443	48	19	regularly	regularly	ADV
cet-15443	48	20	every	every	DET
cet-15443	48	21	24	24	NUM
cet-15443	48	22	h	h	NOUN
cet-15443	48	23	under	under	ADP
cet-15443	48	24	the	the	DET
cet-15443	48	25	simulated	simulate	VERB
cet-15443	48	26	earth	earth	NOUN
cet-15443	48	27	gravity	gravity	NOUN
cet-15443	48	28	conditions	condition	NOUN
cet-15443	48	29	(	(	PUNCT
cet-15443	48	30	figure	figure	NOUN
cet-15443	48	31	3a	3a	NUM
cet-15443	48	32	)	)	PUNCT
cet-15443	48	33	.	.	PUNCT
cet-15443	49	1	the	the	DET
cet-15443	49	2	time	time	NOUN
cet-15443	49	3	profiles	profile	NOUN
cet-15443	49	4	of	of	ADP
cet-15443	49	5	the	the	DET
cet-15443	49	6	md+mdp27	md+mdp27	NOUN
cet-15443	49	7	,	,	PUNCT
cet-15443	49	8	me	i	PRON
cet-15443	49	9	,	,	PUNCT
cet-15443	49	10	ma	ma	PROPN
cet-15443	49	11	,	,	PUNCT
cet-15443	49	12	and	and	CCONJ
cet-15443	49	13	mb	mb	ADJ
cet-15443	49	14	complexes	complex	NOUN
cet-15443	49	15	present	present	VERB
cet-15443	49	16	a	a	DET
cet-15443	49	17	periodic	periodic	ADJ
cet-15443	49	18	pattern	pattern	NOUN
cet-15443	49	19	marking	mark	VERB
cet-15443	49	20	the	the	DET
cet-15443	49	21	transition	transition	NOUN
cet-15443	49	22	1155	1155	NUM
cet-15443	49	23	between	between	ADP
cet-15443	49	24	the	the	DET
cet-15443	49	25	cell	cell	NOUN
cet-15443	49	26	cycle	cycle	NOUN
cet-15443	49	27	phases	phase	NOUN
cet-15443	49	28	(	(	PUNCT
cet-15443	49	29	figure	figure	NOUN
cet-15443	49	30	3b	3b	NUM
cet-15443	49	31	)	)	PUNCT
cet-15443	49	32	.	.	PUNCT
cet-15443	50	1	the	the	DET
cet-15443	50	2	minimum	minimum	ADJ
cet-15443	50	3	concentration	concentration	NOUN
cet-15443	50	4	value	value	NOUN
cet-15443	50	5	of	of	ADP
cet-15443	50	6	md+mdp27	md+mdp27	NOUN
cet-15443	50	7	complexes	complex	NOUN
cet-15443	50	8	marks	mark	VERB
cet-15443	50	9	the	the	DET
cet-15443	50	10	beginning	beginning	NOUN
cet-15443	50	11	of	of	ADP
cet-15443	50	12	the	the	DET
cet-15443	50	13	cell	cell	NOUN
cet-15443	50	14	cycle	cycle	NOUN
cet-15443	50	15	(	(	PUNCT
cet-15443	50	16	g1	g1	PROPN
cet-15443	50	17	)	)	PUNCT
cet-15443	50	18	,	,	PUNCT
cet-15443	50	19	whereas	whereas	SCONJ
cet-15443	50	20	the	the	DET
cet-15443	50	21	maximum	maximum	ADJ
cet-15443	50	22	peak	peak	NOUN
cet-15443	50	23	corresponds	correspond	VERB
cet-15443	50	24	to	to	ADP
cet-15443	50	25	the	the	DET
cet-15443	50	26	begging	begging	NOUN
cet-15443	50	27	of	of	ADP
cet-15443	50	28	s	s	NOUN
cet-15443	50	29	phase	phase	NOUN
cet-15443	50	30	.	.	PUNCT
cet-15443	51	1	the	the	DET
cet-15443	51	2	g2	g2	PROPN
cet-15443	51	3	phase	phase	NOUN
cet-15443	51	4	starts	start	VERB
cet-15443	51	5	with	with	ADP
cet-15443	51	6	the	the	DET
cet-15443	51	7	peak	peak	NOUN
cet-15443	51	8	of	of	ADP
cet-15443	51	9	ma	ma	PROPN
cet-15443	51	10	complex	complex	ADJ
cet-15443	51	11	concentration	concentration	NOUN
cet-15443	51	12	which	which	PRON
cet-15443	51	13	must	must	AUX
cet-15443	51	14	be	be	AUX
cet-15443	51	15	preceded	precede	VERB
cet-15443	51	16	by	by	ADP
cet-15443	51	17	the	the	DET
cet-15443	51	18	peak	peak	NOUN
cet-15443	51	19	of	of	ADP
cet-15443	51	20	me	i	PRON
cet-15443	51	21	complex	complex	ADJ
cet-15443	51	22	concentration	concentration	NOUN
cet-15443	51	23	.	.	PUNCT
cet-15443	52	1	then	then	ADV
cet-15443	52	2	,	,	PUNCT
cet-15443	52	3	m	m	NOUN
cet-15443	52	4	phase	phase	NOUN
cet-15443	52	5	start	start	VERB
cet-15443	52	6	with	with	ADP
cet-15443	52	7	the	the	DET
cet-15443	52	8	peak	peak	NOUN
cet-15443	52	9	of	of	ADP
cet-15443	52	10	mb	mb	ADP
cet-15443	52	11	complex	complex	ADJ
cet-15443	52	12	concentration	concentration	NOUN
cet-15443	52	13	and	and	CCONJ
cet-15443	52	14	ends	end	VERB
cet-15443	52	15	with	with	ADP
cet-15443	52	16	the	the	DET
cet-15443	52	17	beginning	beginning	NOUN
cet-15443	52	18	of	of	ADP
cet-15443	52	19	a	a	DET
cet-15443	52	20	new	new	ADJ
cet-15443	52	21	cell	cell	NOUN
cet-15443	52	22	cycle	cycle	NOUN
cet-15443	52	23	.	.	PUNCT
cet-15443	53	1	figure	figure	VERB
cet-15443	53	2	3	3	NUM
cet-15443	53	3	:	:	PUNCT
cet-15443	53	4	base	base	NOUN
cet-15443	53	5	case	case	NOUN
cet-15443	53	6	:	:	PUNCT
cet-15443	53	7	a	a	X
cet-15443	53	8	)	)	PUNCT
cet-15443	53	9	𝑣𝑠1𝑝27	𝑣𝑠1𝑝27	ADJ
cet-15443	53	10	temporal	temporal	ADJ
cet-15443	53	11	profile	profile	NOUN
cet-15443	53	12	(	(	PUNCT
cet-15443	53	13	solid	solid	ADJ
cet-15443	53	14	line	line	NOUN
cet-15443	53	15	)	)	PUNCT
cet-15443	53	16	and	and	CCONJ
cet-15443	53	17	simulated	simulate	VERB
cet-15443	53	18	duplication	duplication	NOUN
cet-15443	53	19	time	time	NOUN
cet-15443	54	1	𝑡𝐷	𝑡𝐷	NOUN
cet-15443	54	2	(	(	PUNCT
cet-15443	54	3	square	square	ADJ
cet-15443	54	4	symbol	symbol	NOUN
cet-15443	54	5	)	)	PUNCT
cet-15443	54	6	;	;	PUNCT
cet-15443	54	7	b	b	X
cet-15443	54	8	)	)	PUNCT
cet-15443	54	9	on	on	ADP
cet-15443	54	10	the	the	DET
cet-15443	54	11	left	left	ADJ
cet-15443	54	12	scale	scale	NOUN
cet-15443	54	13	simulated	simulate	VERB
cet-15443	54	14	temporal	temporal	ADJ
cet-15443	54	15	profiles	profile	NOUN
cet-15443	54	16	of	of	ADP
cet-15443	54	17	me	i	PRON
cet-15443	54	18	,	,	PUNCT
cet-15443	54	19	ma	ma	PROPN
cet-15443	54	20	and	and	CCONJ
cet-15443	54	21	mb	mb	ADP
cet-15443	54	22	active	active	ADJ
cet-15443	54	23	complexes	complex	NOUN
cet-15443	54	24	and	and	CCONJ
cet-15443	54	25	on	on	ADP
cet-15443	54	26	the	the	DET
cet-15443	54	27	right	right	ADJ
cet-15443	54	28	scale	scale	NOUN
cet-15443	54	29	simulated	simulate	VERB
cet-15443	54	30	sum	sum	NOUN
cet-15443	54	31	of	of	ADP
cet-15443	54	32	md	md	PROPN
cet-15443	54	33	active	active	ADJ
cet-15443	54	34	and	and	CCONJ
cet-15443	54	35	mdp27	mdp27	PROPN
cet-15443	54	36	inhibited	inhibit	VERB
cet-15443	54	37	by	by	ADP
cet-15443	54	38	p21	p21	NOUN
cet-15443	54	39	/	/	SYM
cet-15443	54	40	p27	p27	NOUN
cet-15443	54	41	complexes	complex	NOUN
cet-15443	54	42	.	.	PUNCT
cet-15443	55	1	3.2	3.2	NUM
cet-15443	55	2	case	case	NOUN
cet-15443	55	3	1	1	NUM
cet-15443	55	4	the	the	DET
cet-15443	55	5	cell	cell	NOUN
cet-15443	55	6	duplication	duplication	NOUN
cet-15443	55	7	increases	increase	VERB
cet-15443	55	8	progressively	progressively	ADV
cet-15443	55	9	during	during	ADP
cet-15443	55	10	the	the	DET
cet-15443	55	11	first	first	ADJ
cet-15443	55	12	4	4	NUM
cet-15443	55	13	days	day	NOUN
cet-15443	55	14	to	to	PART
cet-15443	55	15	reach	reach	VERB
cet-15443	55	16	a	a	DET
cet-15443	55	17	bi	bi	ADJ
cet-15443	55	18	-	-	ADJ
cet-15443	55	19	periodic	periodic	ADJ
cet-15443	55	20	regime	regime	NOUN
cet-15443	55	21	(	(	PUNCT
cet-15443	55	22	figure	figure	NOUN
cet-15443	55	23	4a	4a	NOUN
cet-15443	55	24	)	)	PUNCT
cet-15443	55	25	characterized	characterize	VERB
cet-15443	55	26	by	by	ADP
cet-15443	55	27	two	two	NUM
cet-15443	55	28	alternated	alternate	VERB
cet-15443	55	29	duplication	duplication	NOUN
cet-15443	55	30	times	time	NOUN
cet-15443	55	31	(	(	PUNCT
cet-15443	55	32	32	32	NUM
cet-15443	55	33	and	and	CCONJ
cet-15443	55	34	53	53	NUM
cet-15443	55	35	h	h	NOUN
cet-15443	55	36	)	)	PUNCT
cet-15443	55	37	both	both	CCONJ
cet-15443	55	38	larger	large	ADJ
cet-15443	55	39	than	than	ADP
cet-15443	55	40	the	the	DET
cet-15443	55	41	one	one	NUM
cet-15443	55	42	observed	observe	VERB
cet-15443	55	43	under	under	ADP
cet-15443	55	44	physiological	physiological	ADJ
cet-15443	55	45	condition	condition	NOUN
cet-15443	55	46	(	(	PUNCT
cet-15443	55	47	24	24	NUM
cet-15443	55	48	h	h	NOUN
cet-15443	55	49	)	)	PUNCT
cet-15443	55	50	.	.	PUNCT
cet-15443	56	1	the	the	DET
cet-15443	56	2	duplication	duplication	NOUN
cet-15443	56	3	time	time	NOUN
cet-15443	56	4	increase	increase	NOUN
cet-15443	56	5	observed	observe	VERB
cet-15443	56	6	in	in	ADP
cet-15443	56	7	our	our	PRON
cet-15443	56	8	simulation	simulation	NOUN
cet-15443	56	9	is	be	AUX
cet-15443	56	10	consistent	consistent	ADJ
cet-15443	56	11	with	with	ADP
cet-15443	56	12	the	the	DET
cet-15443	56	13	experimental	experimental	ADJ
cet-15443	56	14	findings	finding	NOUN
cet-15443	56	15	reported	report	VERB
cet-15443	56	16	by	by	ADP
cet-15443	56	17	coinu	coinu	NOUN
cet-15443	56	18	et	et	NOUN
cet-15443	56	19	al	al	PROPN
cet-15443	56	20	.	.	PROPN
cet-15443	56	21	,	,	PUNCT
cet-15443	56	22	(	(	PUNCT
cet-15443	56	23	2006	2006	NUM
cet-15443	56	24	)	)	PUNCT
cet-15443	56	25	.	.	PUNCT
cet-15443	57	1	in	in	ADP
cet-15443	57	2	particular	particular	ADJ
cet-15443	57	3	,	,	PUNCT
cet-15443	57	4	in	in	ADP
cet-15443	57	5	that	that	DET
cet-15443	57	6	study	study	NOUN
cet-15443	57	7	the	the	DET
cet-15443	57	8	overexpression	overexpression	NOUN
cet-15443	57	9	of	of	ADP
cet-15443	57	10	the	the	DET
cet-15443	57	11	p21	p21	NOUN
cet-15443	57	12	gene	gene	NOUN
cet-15443	57	13	caused	cause	VERB
cet-15443	57	14	a	a	DET
cet-15443	57	15	cell	cell	NOUN
cet-15443	57	16	cycle	cycle	NOUN
cet-15443	57	17	characterized	characterize	VERB
cet-15443	57	18	by	by	ADP
cet-15443	57	19	a	a	DET
cet-15443	57	20	cell	cell	NOUN
cet-15443	57	21	duplication	duplication	NOUN
cet-15443	57	22	time	time	NOUN
cet-15443	57	23	greater	great	ADJ
cet-15443	57	24	than	than	ADP
cet-15443	57	25	24	24	NUM
cet-15443	57	26	h.	h.	NOUN
cet-15443	57	27	for	for	ADP
cet-15443	57	28	a	a	DET
cet-15443	57	29	cell	cell	NOUN
cet-15443	57	30	duplication	duplication	NOUN
cet-15443	57	31	time	time	NOUN
cet-15443	57	32	of	of	ADP
cet-15443	57	33	32	32	NUM
cet-15443	57	34	h	h	NOUN
cet-15443	57	35	the	the	DET
cet-15443	57	36	dna	dna	PROPN
cet-15443	57	37	replication	replication	NOUN
cet-15443	57	38	is	be	AUX
cet-15443	57	39	still	still	ADV
cet-15443	57	40	normal	normal	ADJ
cet-15443	57	41	as	as	SCONJ
cet-15443	57	42	the	the	DET
cet-15443	57	43	one	one	NUM
cet-15443	57	44	observed	observe	VERB
cet-15443	57	45	for	for	ADP
cet-15443	57	46	24	24	NUM
cet-15443	57	47	h.	h.	NOUN
cet-15443	57	48	in	in	ADP
cet-15443	57	49	contrast	contrast	NOUN
cet-15443	57	50	,	,	PUNCT
cet-15443	57	51	for	for	ADP
cet-15443	57	52	a	a	DET
cet-15443	57	53	cell	cell	NOUN
cet-15443	57	54	duplication	duplication	NOUN
cet-15443	57	55	time	time	NOUN
cet-15443	57	56	of	of	ADP
cet-15443	57	57	53	53	NUM
cet-15443	57	58	h	h	NOUN
cet-15443	57	59	the	the	DET
cet-15443	57	60	dna	dna	PROPN
cet-15443	57	61	is	be	AUX
cet-15443	57	62	quadrupled	quadruple	VERB
cet-15443	57	63	before	before	ADP
cet-15443	57	64	cell	cell	NOUN
cet-15443	57	65	division	division	NOUN
cet-15443	57	66	(	(	PUNCT
cet-15443	57	67	i.e.	i.e.	X
cet-15443	57	68	tetraploidy	tetraploidy	ADJ
cet-15443	57	69	)	)	PUNCT
cet-15443	57	70	.	.	PUNCT
cet-15443	58	1	this	this	DET
cet-15443	58	2	phenomenon	phenomenon	NOUN
cet-15443	58	3	is	be	AUX
cet-15443	58	4	highlighted	highlight	VERB
cet-15443	58	5	by	by	ADP
cet-15443	58	6	the	the	DET
cet-15443	58	7	repetition	repetition	NOUN
cet-15443	58	8	of	of	ADP
cet-15443	58	9	g1	g1	PROPN
cet-15443	58	10	phase	phase	NOUN
cet-15443	58	11	after	after	ADP
cet-15443	58	12	g1	g1	PROPN
cet-15443	58	13	/	/	SYM
cet-15443	58	14	s	s	PART
cet-15443	58	15	phase	phase	NOUN
cet-15443	58	16	(	(	PUNCT
cet-15443	58	17	figure	figure	NOUN
cet-15443	58	18	4b	4b	PROPN
cet-15443	58	19	)	)	PUNCT
cet-15443	58	20	.	.	PUNCT
cet-15443	59	1	additionally	additionally	ADV
cet-15443	59	2	,	,	PUNCT
cet-15443	59	3	the	the	DET
cet-15443	59	4	microgravity	microgravity	NOUN
cet-15443	59	5	condition	condition	NOUN
cet-15443	59	6	appears	appear	VERB
cet-15443	59	7	to	to	PART
cet-15443	59	8	short	short	VERB
cet-15443	59	9	the	the	DET
cet-15443	59	10	duration	duration	NOUN
cet-15443	59	11	of	of	ADP
cet-15443	59	12	phase	phase	NOUN
cet-15443	59	13	s	s	PART
cet-15443	59	14	(	(	PUNCT
cet-15443	59	15	figure	figure	NOUN
cet-15443	59	16	4b	4b	PROPN
cet-15443	59	17	)	)	PUNCT
cet-15443	59	18	characterized	characterize	VERB
cet-15443	59	19	by	by	ADP
cet-15443	59	20	higher	high	ADJ
cet-15443	59	21	peak	peak	NOUN
cet-15443	59	22	of	of	ADP
cet-15443	59	23	the	the	DET
cet-15443	59	24	active	active	ADJ
cet-15443	59	25	me	i	PRON
cet-15443	59	26	and	and	CCONJ
cet-15443	59	27	ma	ma	PROPN
cet-15443	59	28	complexes	complex	NOUN
cet-15443	59	29	than	than	ADP
cet-15443	59	30	those	those	PRON
cet-15443	59	31	observed	observe	VERB
cet-15443	59	32	for	for	ADP
cet-15443	59	33	earth	earth	NOUN
cet-15443	59	34	gravity	gravity	NOUN
cet-15443	59	35	(	(	PUNCT
cet-15443	59	36	figure	figure	NOUN
cet-15443	59	37	3b	3b	NUM
cet-15443	59	38	)	)	PUNCT
cet-15443	59	39	.	.	PUNCT
cet-15443	60	1	figure	figure	VERB
cet-15443	60	2	4	4	NUM
cet-15443	60	3	:	:	PUNCT
cet-15443	60	4	case	case	NOUN
cet-15443	60	5	1	1	NUM
cet-15443	60	6	:	:	PUNCT
cet-15443	60	7	a	a	X
cet-15443	60	8	)	)	PUNCT
cet-15443	60	9	𝑣𝑠1𝑝27	𝑣𝑠1𝑝27	ADJ
cet-15443	60	10	temporal	temporal	ADJ
cet-15443	60	11	profile	profile	NOUN
cet-15443	60	12	(	(	PUNCT
cet-15443	60	13	solid	solid	ADJ
cet-15443	60	14	line	line	NOUN
cet-15443	60	15	)	)	PUNCT
cet-15443	60	16	and	and	CCONJ
cet-15443	60	17	simulated	simulate	VERB
cet-15443	60	18	duplication	duplication	NOUN
cet-15443	60	19	time	time	NOUN
cet-15443	60	20	𝑡𝐷	𝑡𝐷	NOUN
cet-15443	60	21	(	(	PUNCT
cet-15443	60	22	square	square	ADJ
cet-15443	60	23	symbol	symbol	NOUN
cet-15443	60	24	)	)	PUNCT
cet-15443	60	25	;	;	PUNCT
cet-15443	61	1	b	b	X
cet-15443	61	2	)	)	PUNCT
cet-15443	61	3	on	on	ADP
cet-15443	61	4	the	the	DET
cet-15443	61	5	left	left	ADJ
cet-15443	61	6	scale	scale	NOUN
cet-15443	61	7	simulated	simulate	VERB
cet-15443	61	8	temporal	temporal	ADJ
cet-15443	61	9	profiles	profile	NOUN
cet-15443	61	10	of	of	ADP
cet-15443	61	11	me	i	PRON
cet-15443	61	12	,	,	PUNCT
cet-15443	61	13	ma	ma	PROPN
cet-15443	61	14	and	and	CCONJ
cet-15443	61	15	mb	mb	ADP
cet-15443	61	16	active	active	ADJ
cet-15443	61	17	complexes	complex	NOUN
cet-15443	61	18	and	and	CCONJ
cet-15443	61	19	on	on	ADP
cet-15443	61	20	the	the	DET
cet-15443	61	21	right	right	ADJ
cet-15443	61	22	scale	scale	NOUN
cet-15443	61	23	simulated	simulate	VERB
cet-15443	61	24	sum	sum	NOUN
cet-15443	61	25	of	of	ADP
cet-15443	61	26	md	md	PROPN
cet-15443	61	27	active	active	ADJ
cet-15443	61	28	and	and	CCONJ
cet-15443	61	29	mdp27	mdp27	PROPN
cet-15443	61	30	inhibited	inhibit	VERB
cet-15443	61	31	by	by	ADP
cet-15443	61	32	p21	p21	NOUN
cet-15443	61	33	/	/	SYM
cet-15443	61	34	p27	p27	NOUN
cet-15443	61	35	complexes	complex	NOUN
cet-15443	61	36	.	.	PUNCT
cet-15443	62	1	0	0	NUM
cet-15443	62	2	1	1	NUM
cet-15443	62	3	2	2	NUM
cet-15443	62	4	3	3	NUM
cet-15443	62	5	4	4	NUM
cet-15443	62	6	5	5	NUM
cet-15443	62	7	6	6	NUM
cet-15443	62	8	7	7	NUM
cet-15443	62	9	8	8	NUM
cet-15443	62	10	9	9	NUM
cet-15443	62	11	10	10	NUM
cet-15443	62	12	0.0	0.0	NUM
cet-15443	62	13	0.8	0.8	NUM
cet-15443	62	14	1.6	1.6	NUM
cet-15443	62	15	2.4	2.4	NUM
cet-15443	62	16	3.2	3.2	NUM
cet-15443	62	17	4.0	4.0	NUM
cet-15443	62	18	4.8	4.8	NUM
cet-15443	62	19	n	n	NOUN
cet-15443	62	20	s	s	NOUN
cet-15443	62	21	1	1	NUM
cet-15443	62	22	p	p	NOUN
cet-15443	62	23	2	2	NUM
cet-15443	62	24	7	7	NUM
cet-15443	62	25	[	[	PUNCT
cet-15443	62	26	m	m	VERB
cet-15443	62	27	m	m	VERB
cet-15443	62	28	h	h	NOUN
cet-15443	62	29	-1	-1	X
cet-15443	62	30	]	]	PUNCT
cet-15443	62	31	time	time	NOUN
cet-15443	62	32	[	[	X
cet-15443	62	33	d	d	X
cet-15443	62	34	]	]	X
cet-15443	62	35	0	0	NUM
cet-15443	62	36	24	24	NUM
cet-15443	62	37	48	48	NUM
cet-15443	62	38	72	72	NUM
cet-15443	62	39	96	96	NUM
cet-15443	62	40	120	120	NUM
cet-15443	62	41	td	td	NOUN
cet-15443	63	1	[	[	X
cet-15443	63	2	h	h	X
cet-15443	63	3	]	]	X
cet-15443	63	4	0	0	NUM
cet-15443	63	5	24	24	NUM
cet-15443	63	6	48	48	NUM
cet-15443	63	7	72	72	NUM
cet-15443	63	8	96	96	NUM
cet-15443	63	9	0.0	0.0	NUM
cet-15443	63	10	0.2	0.2	NUM
cet-15443	63	11	0.4	0.4	NUM
cet-15443	63	12	0.6	0.6	NUM
cet-15443	63	13	0.8	0.8	NUM
cet-15443	63	14	1.0	1.0	NUM
cet-15443	63	15	1.2	1.2	NUM
cet-15443	63	16	m	m	NOUN
cet-15443	63	17	e	e	NOUN
cet-15443	63	18	,	,	PUNCT
cet-15443	63	19	m	m	VERB
cet-15443	63	20	a	a	PRON
cet-15443	63	21	,	,	PUNCT
cet-15443	63	22	m	m	PROPN
cet-15443	63	23	b	b	X
cet-15443	63	24	[	[	PUNCT
cet-15443	63	25	m	m	VERB
cet-15443	63	26	m	m	VERB
cet-15443	63	27	]	]	X
cet-15443	63	28	time	time	NOUN
cet-15443	64	1	[	[	X
cet-15443	64	2	h	h	X
cet-15443	64	3	]	]	X
cet-15443	64	4	g1	g1	PROPN
cet-15443	64	5	g2s	g2s	PROPN
cet-15443	64	6	m	m	PROPN
cet-15443	65	1	1.0	1.0	NUM
cet-15443	65	2	1.1	1.1	NUM
cet-15443	65	3	1.2	1.2	NUM
cet-15443	65	4	1.3	1.3	NUM
cet-15443	65	5	1.4	1.4	NUM
cet-15443	65	6	1.5	1.5	NUM
cet-15443	65	7	m	m	NOUN
cet-15443	65	8	d	d	NOUN
cet-15443	65	9	+	+	NOUN
cet-15443	65	10	m	m	VERB
cet-15443	65	11	d	d	NOUN
cet-15443	65	12	p	p	VERB
cet-15443	65	13	2	2	NUM
cet-15443	65	14	7	7	NUM
cet-15443	66	1	[	[	X
cet-15443	66	2	m	m	VERB
cet-15443	66	3	m	m	VERB
cet-15443	66	4	]	]	X
cet-15443	66	5	0	0	NUM
cet-15443	66	6	2	2	NUM
cet-15443	66	7	4	4	NUM
cet-15443	66	8	6	6	NUM
cet-15443	66	9	8	8	NUM
cet-15443	66	10	10	10	NUM
cet-15443	66	11	12	12	NUM
cet-15443	66	12	14	14	NUM
cet-15443	66	13	16	16	NUM
cet-15443	66	14	18	18	NUM
cet-15443	66	15	20	20	NUM
cet-15443	66	16	22	22	NUM
cet-15443	66	17	24	24	NUM
cet-15443	66	18	26	26	NUM
cet-15443	66	19	28	28	NUM
cet-15443	66	20	0.0	0.0	NUM
cet-15443	66	21	0.8	0.8	NUM
cet-15443	66	22	1.6	1.6	NUM
cet-15443	66	23	2.4	2.4	NUM
cet-15443	66	24	3.2	3.2	NUM
cet-15443	66	25	4.0	4.0	NUM
cet-15443	66	26	4.8	4.8	NUM
cet-15443	66	27	n	n	NOUN
cet-15443	66	28	s	s	NOUN
cet-15443	66	29	1	1	NUM
cet-15443	66	30	p	p	NOUN
cet-15443	66	31	2	2	NUM
cet-15443	66	32	7	7	NUM
cet-15443	66	33	[	[	PUNCT
cet-15443	66	34	m	m	VERB
cet-15443	66	35	m	m	VERB
cet-15443	66	36	h	h	NOUN
cet-15443	66	37	-1	-1	X
cet-15443	66	38	]	]	PUNCT
cet-15443	66	39	time	time	NOUN
cet-15443	67	1	[	[	X
cet-15443	67	2	d	d	X
cet-15443	67	3	]	]	X
cet-15443	67	4	0	0	NUM
cet-15443	67	5	24	24	NUM
cet-15443	67	6	48	48	NUM
cet-15443	67	7	72	72	NUM
cet-15443	67	8	96	96	NUM
cet-15443	67	9	120	120	NUM
cet-15443	67	10	td	td	NOUN
cet-15443	68	1	[	[	X
cet-15443	68	2	h	h	X
cet-15443	68	3	]	]	X
cet-15443	68	4	0	0	NUM
cet-15443	68	5	1	1	NUM
cet-15443	68	6	2	2	NUM
cet-15443	68	7	3	3	NUM
cet-15443	68	8	4	4	NUM
cet-15443	68	9	23	23	NUM
cet-15443	68	10	24	24	NUM
cet-15443	68	11	25	25	NUM
cet-15443	68	12	26	26	NUM
cet-15443	68	13	0.0	0.0	NUM
cet-15443	68	14	0.2	0.2	NUM
cet-15443	68	15	0.4	0.4	NUM
cet-15443	68	16	0.6	0.6	NUM
cet-15443	68	17	0.8	0.8	NUM
cet-15443	68	18	1.0	1.0	NUM
cet-15443	68	19	1.2	1.2	NUM
cet-15443	68	20	1.4	1.4	NUM
cet-15443	68	21	m	m	NOUN
cet-15443	68	22	e	e	NOUN
cet-15443	68	23	,	,	PUNCT
cet-15443	68	24	m	m	VERB
cet-15443	68	25	a	a	PRON
cet-15443	68	26	,	,	PUNCT
cet-15443	68	27	m	m	PROPN
cet-15443	68	28	b	b	X
cet-15443	68	29	[	[	PUNCT
cet-15443	68	30	m	m	VERB
cet-15443	68	31	m	m	VERB
cet-15443	68	32	]	]	X
cet-15443	68	33	time	time	NOUN
cet-15443	69	1	[	[	X
cet-15443	69	2	d	d	X
cet-15443	69	3	]	]	X
cet-15443	69	4	g1	g1	PROPN
cet-15443	69	5	s	s	PROPN
cet-15443	69	6	g2	g2	PROPN
cet-15443	69	7	g2	g2	PROPN
cet-15443	69	8	m	m	PROPN
cet-15443	69	9	msg1	msg1	PROPN
cet-15443	69	10	/	/	SYM
cet-15443	69	11	s	s	PART
cet-15443	69	12	g1	g1	PROPN
cet-15443	69	13	1.0	1.0	NUM
cet-15443	69	14	1.1	1.1	NUM
cet-15443	69	15	1.2	1.2	NUM
cet-15443	69	16	1.3	1.3	NUM
cet-15443	69	17	1.4	1.4	NUM
cet-15443	69	18	1.5	1.5	NUM
cet-15443	69	19	m	m	NOUN
cet-15443	69	20	d	d	NOUN
cet-15443	70	1	+	+	NOUN
cet-15443	70	2	m	m	VERB
cet-15443	70	3	d	d	NOUN
cet-15443	70	4	p	p	VERB
cet-15443	70	5	2	2	NUM
cet-15443	70	6	7	7	NUM
cet-15443	71	1	[	[	X
cet-15443	71	2	m	m	VERB
cet-15443	71	3	m	m	VERB
cet-15443	71	4	]	]	X
cet-15443	71	5	(	(	PUNCT
cet-15443	71	6	a	a	NOUN
cet-15443	71	7	)	)	PUNCT
cet-15443	71	8	(	(	PUNCT
cet-15443	71	9	b	b	X
cet-15443	71	10	)	)	PUNCT
cet-15443	71	11	(	(	PUNCT
cet-15443	71	12	a	a	X
cet-15443	71	13	)	)	PUNCT
cet-15443	71	14	(	(	PUNCT
cet-15443	71	15	b	b	X
cet-15443	71	16	)	)	PUNCT
cet-15443	71	17	1156	1156	NUM
cet-15443	71	18	3.3	3.3	NUM
cet-15443	71	19	case	case	NOUN
cet-15443	71	20	2	2	NUM
cet-15443	71	21	similarly	similarly	ADV
cet-15443	71	22	to	to	ADP
cet-15443	71	23	the	the	DET
cet-15443	71	24	case	case	NOUN
cet-15443	71	25	1	1	NUM
cet-15443	71	26	,	,	PUNCT
cet-15443	71	27	the	the	DET
cet-15443	71	28	cell	cell	NOUN
cet-15443	71	29	duplication	duplication	NOUN
cet-15443	71	30	increases	increase	VERB
cet-15443	71	31	progressively	progressively	ADV
cet-15443	71	32	during	during	ADP
cet-15443	71	33	the	the	DET
cet-15443	71	34	first	first	ADJ
cet-15443	71	35	8	8	NUM
cet-15443	71	36	days	day	NOUN
cet-15443	71	37	to	to	PART
cet-15443	71	38	reach	reach	VERB
cet-15443	71	39	a	a	DET
cet-15443	71	40	periodic	periodic	ADJ
cet-15443	71	41	regime	regime	NOUN
cet-15443	71	42	(	(	PUNCT
cet-15443	71	43	figure	figure	NOUN
cet-15443	71	44	5a	5a	NUM
cet-15443	71	45	)	)	PUNCT
cet-15443	71	46	with	with	ADP
cet-15443	71	47	a	a	DET
cet-15443	71	48	duplication	duplication	NOUN
cet-15443	71	49	time	time	NOUN
cet-15443	71	50	of	of	ADP
cet-15443	71	51	97	97	NUM
cet-15443	71	52	h.	h.	NOUN
cet-15443	71	53	overall	overall	NOUN
cet-15443	71	54	,	,	PUNCT
cet-15443	71	55	in	in	ADP
cet-15443	71	56	comparison	comparison	NOUN
cet-15443	71	57	to	to	ADP
cet-15443	71	58	case	case	NOUN
cet-15443	71	59	1	1	NUM
cet-15443	71	60	,	,	PUNCT
cet-15443	71	61	the	the	DET
cet-15443	71	62	increase	increase	NOUN
cet-15443	71	63	of	of	ADP
cet-15443	71	64	the	the	DET
cet-15443	71	65	𝑣𝑠1𝑝27	𝑣𝑠1𝑝27	ADJ
cet-15443	71	66	parameter	parameter	NOUN
cet-15443	71	67	value	value	NOUN
cet-15443	71	68	observed	observe	VERB
cet-15443	71	69	is	be	AUX
cet-15443	71	70	amplified	amplify	VERB
cet-15443	71	71	for	for	ADP
cet-15443	71	72	both	both	DET
cet-15443	71	73	duplication	duplication	NOUN
cet-15443	71	74	time	time	NOUN
cet-15443	71	75	(	(	PUNCT
cet-15443	71	76	figure	figure	NOUN
cet-15443	71	77	5a	5a	NUM
cet-15443	71	78	)	)	PUNCT
cet-15443	71	79	and	and	CCONJ
cet-15443	71	80	peak	peak	NOUN
cet-15443	71	81	of	of	ADP
cet-15443	71	82	md+mdp27	md+mdp27	NOUN
cet-15443	71	83	,	,	PUNCT
cet-15443	71	84	me	i	PRON
cet-15443	71	85	,	,	PUNCT
cet-15443	71	86	and	and	CCONJ
cet-15443	71	87	ma	ma	PROPN
cet-15443	71	88	complexes	complex	NOUN
cet-15443	71	89	(	(	PUNCT
cet-15443	71	90	figure	figure	NOUN
cet-15443	71	91	5b	5b	NUM
cet-15443	71	92	)	)	PUNCT
cet-15443	71	93	.	.	PUNCT
cet-15443	72	1	thus	thus	ADV
cet-15443	72	2	,	,	PUNCT
cet-15443	72	3	under	under	ADP
cet-15443	72	4	these	these	DET
cet-15443	72	5	conditions	condition	NOUN
cet-15443	72	6	,	,	PUNCT
cet-15443	72	7	all	all	DET
cet-15443	72	8	cell	cell	NOUN
cet-15443	72	9	duplications	duplication	NOUN
cet-15443	72	10	occur	occur	VERB
cet-15443	72	11	with	with	ADP
cet-15443	72	12	tetraploidy	tetraploidy	ADJ
cet-15443	72	13	.	.	PUNCT
cet-15443	73	1	opposed	oppose	VERB
cet-15443	73	2	to	to	ADP
cet-15443	73	3	the	the	DET
cet-15443	73	4	me	me	PROPN
cet-15443	73	5	and	and	CCONJ
cet-15443	73	6	ma	ma	PROPN
cet-15443	73	7	temporal	temporal	PROPN
cet-15443	73	8	profile	profile	NOUN
cet-15443	73	9	observed	observe	VERB
cet-15443	73	10	for	for	ADP
cet-15443	73	11	case	case	NOUN
cet-15443	73	12	1	1	NUM
cet-15443	73	13	(	(	PUNCT
cet-15443	73	14	figure	figure	NOUN
cet-15443	73	15	4b	4b	PROPN
cet-15443	73	16	)	)	PUNCT
cet-15443	73	17	,	,	PUNCT
cet-15443	73	18	in	in	ADP
cet-15443	73	19	case	case	NOUN
cet-15443	73	20	2	2	NUM
cet-15443	73	21	the	the	DET
cet-15443	73	22	peak	peak	NOUN
cet-15443	73	23	of	of	ADP
cet-15443	73	24	me	i	PRON
cet-15443	73	25	is	be	AUX
cet-15443	73	26	higher	high	ADJ
cet-15443	73	27	than	than	ADP
cet-15443	73	28	that	that	PRON
cet-15443	73	29	of	of	ADP
cet-15443	73	30	ma	ma	PROPN
cet-15443	73	31	(	(	PUNCT
cet-15443	73	32	figure	figure	NOUN
cet-15443	73	33	5b	5b	NUM
cet-15443	73	34	)	)	PUNCT
cet-15443	73	35	.	.	PUNCT
cet-15443	74	1	figure	figure	VERB
cet-15443	74	2	5	5	NUM
cet-15443	74	3	:	:	PUNCT
cet-15443	74	4	case	case	NOUN
cet-15443	74	5	2	2	NUM
cet-15443	74	6	:	:	PUNCT
cet-15443	74	7	a	a	X
cet-15443	74	8	)	)	PUNCT
cet-15443	74	9	𝑣𝑠1𝑝27	𝑣𝑠1𝑝27	ADJ
cet-15443	74	10	temporal	temporal	ADJ
cet-15443	74	11	profile	profile	NOUN
cet-15443	74	12	(	(	PUNCT
cet-15443	74	13	solid	solid	ADJ
cet-15443	74	14	line	line	NOUN
cet-15443	74	15	)	)	PUNCT
cet-15443	74	16	and	and	CCONJ
cet-15443	74	17	simulated	simulate	VERB
cet-15443	74	18	duplication	duplication	NOUN
cet-15443	74	19	time	time	NOUN
cet-15443	74	20	𝑡𝐷	𝑡𝐷	NOUN
cet-15443	74	21	(	(	PUNCT
cet-15443	74	22	square	square	ADJ
cet-15443	74	23	symbol	symbol	NOUN
cet-15443	74	24	)	)	PUNCT
cet-15443	74	25	;	;	PUNCT
cet-15443	75	1	b	b	X
cet-15443	75	2	)	)	PUNCT
cet-15443	75	3	on	on	ADP
cet-15443	75	4	the	the	DET
cet-15443	75	5	left	left	ADJ
cet-15443	75	6	scale	scale	NOUN
cet-15443	75	7	simulated	simulate	VERB
cet-15443	75	8	temporal	temporal	ADJ
cet-15443	75	9	profiles	profile	NOUN
cet-15443	75	10	of	of	ADP
cet-15443	75	11	me	i	PRON
cet-15443	75	12	,	,	PUNCT
cet-15443	75	13	ma	ma	PROPN
cet-15443	75	14	and	and	CCONJ
cet-15443	75	15	mb	mb	ADP
cet-15443	75	16	active	active	ADJ
cet-15443	75	17	complexes	complex	NOUN
cet-15443	75	18	and	and	CCONJ
cet-15443	75	19	on	on	ADP
cet-15443	75	20	the	the	DET
cet-15443	75	21	right	right	ADJ
cet-15443	75	22	scale	scale	NOUN
cet-15443	75	23	simulated	simulate	VERB
cet-15443	75	24	sum	sum	NOUN
cet-15443	75	25	of	of	ADP
cet-15443	75	26	md	md	PROPN
cet-15443	75	27	active	active	ADJ
cet-15443	75	28	and	and	CCONJ
cet-15443	75	29	mdp27	mdp27	PROPN
cet-15443	75	30	inhibited	inhibit	VERB
cet-15443	75	31	by	by	ADP
cet-15443	75	32	p21	p21	NOUN
cet-15443	75	33	/	/	SYM
cet-15443	75	34	p27	p27	NOUN
cet-15443	75	35	complexes	complex	NOUN
cet-15443	75	36	.	.	PUNCT
cet-15443	76	1	3.4	3.4	NUM
cet-15443	76	2	case	case	NOUN
cet-15443	76	3	3	3	NUM
cet-15443	76	4	in	in	ADP
cet-15443	76	5	this	this	DET
cet-15443	76	6	scenario	scenario	NOUN
cet-15443	76	7	the	the	DET
cet-15443	76	8	microgravity	microgravity	NOUN
cet-15443	76	9	conditions	condition	NOUN
cet-15443	76	10	simulated	simulate	VERB
cet-15443	76	11	are	be	AUX
cet-15443	76	12	extreme	extreme	ADJ
cet-15443	76	13	and	and	CCONJ
cet-15443	76	14	represent	represent	VERB
cet-15443	76	15	a	a	DET
cet-15443	76	16	p21	p21	NOUN
cet-15443	76	17	/	/	SYM
cet-15443	76	18	p27	p27	NOUN
cet-15443	76	19	overexpression	overexpression	NOUN
cet-15443	76	20	capable	capable	ADJ
cet-15443	76	21	to	to	PART
cet-15443	76	22	arrest	arrest	VERB
cet-15443	76	23	the	the	DET
cet-15443	76	24	cell	cell	NOUN
cet-15443	76	25	cycle	cycle	NOUN
cet-15443	76	26	(	(	PUNCT
cet-15443	76	27	figure	figure	VERB
cet-15443	76	28	6a	6a	NOUN
cet-15443	76	29	)	)	PUNCT
cet-15443	76	30	without	without	ADP
cet-15443	76	31	the	the	DET
cet-15443	76	32	periodic	periodic	ADJ
cet-15443	76	33	oscillations	oscillation	NOUN
cet-15443	76	34	(	(	PUNCT
cet-15443	76	35	figure	figure	NOUN
cet-15443	76	36	6b	6b	NUM
cet-15443	76	37	)	)	PUNCT
cet-15443	76	38	.	.	PUNCT
cet-15443	77	1	under	under	ADP
cet-15443	77	2	such	such	ADJ
cet-15443	77	3	extreme	extreme	ADJ
cet-15443	77	4	conditions	condition	NOUN
cet-15443	77	5	,	,	PUNCT
cet-15443	77	6	model	model	NOUN
cet-15443	77	7	simulations	simulation	NOUN
cet-15443	77	8	show	show	VERB
cet-15443	77	9	that	that	SCONJ
cet-15443	77	10	,	,	PUNCT
cet-15443	77	11	after	after	ADP
cet-15443	77	12	a	a	DET
cet-15443	77	13	single	single	ADJ
cet-15443	77	14	“	"	PUNCT
cet-15443	77	15	normal	normal	ADJ
cet-15443	77	16	”	"	PUNCT
cet-15443	77	17	cell	cell	NOUN
cet-15443	77	18	duplication	duplication	NOUN
cet-15443	77	19	taking	take	VERB
cet-15443	77	20	place	place	NOUN
cet-15443	77	21	in	in	ADP
cet-15443	77	22	1.5	1.5	NUM
cet-15443	77	23	days	day	NOUN
cet-15443	77	24	,	,	PUNCT
cet-15443	77	25	cell	cell	NOUN
cet-15443	77	26	cycle	cycle	NOUN
cet-15443	77	27	is	be	AUX
cet-15443	77	28	eventually	eventually	ADV
cet-15443	77	29	arrested	arrest	VERB
cet-15443	77	30	.	.	PUNCT
cet-15443	78	1	the	the	DET
cet-15443	78	2	concentration	concentration	NOUN
cet-15443	78	3	of	of	ADP
cet-15443	78	4	the	the	DET
cet-15443	78	5	active	active	ADJ
cet-15443	78	6	me	i	PRON
cet-15443	78	7	,	,	PUNCT
cet-15443	78	8	ma	ma	PROPN
cet-15443	78	9	and	and	CCONJ
cet-15443	78	10	mb	mb	ADJ
cet-15443	78	11	complexes	complex	NOUN
cet-15443	78	12	do	do	AUX
cet-15443	78	13	not	not	PART
cet-15443	78	14	show	show	VERB
cet-15443	78	15	a	a	DET
cet-15443	78	16	peak	peak	NOUN
cet-15443	78	17	because	because	SCONJ
cet-15443	78	18	of	of	ADP
cet-15443	78	19	the	the	DET
cet-15443	78	20	p21	p21	NOUN
cet-15443	78	21	inhibitory	inhibitory	ADJ
cet-15443	78	22	effect	effect	NOUN
cet-15443	78	23	(	(	PUNCT
cet-15443	78	24	figure	figure	NOUN
cet-15443	78	25	6b	6b	NUM
cet-15443	78	26	)	)	PUNCT
cet-15443	78	27	.	.	PUNCT
cet-15443	79	1	figure	figure	VERB
cet-15443	79	2	6	6	NUM
cet-15443	79	3	:	:	PUNCT
cet-15443	79	4	case	case	NOUN
cet-15443	79	5	3	3	NUM
cet-15443	79	6	:	:	PUNCT
cet-15443	79	7	a	a	X
cet-15443	79	8	)	)	PUNCT
cet-15443	79	9	𝑣𝑠1𝑝27	𝑣𝑠1𝑝27	ADJ
cet-15443	79	10	temporal	temporal	ADJ
cet-15443	79	11	profile	profile	NOUN
cet-15443	79	12	(	(	PUNCT
cet-15443	79	13	solid	solid	ADJ
cet-15443	79	14	line	line	NOUN
cet-15443	79	15	)	)	PUNCT
cet-15443	79	16	and	and	CCONJ
cet-15443	79	17	simulated	simulate	VERB
cet-15443	79	18	duplication	duplication	NOUN
cet-15443	79	19	time	time	NOUN
cet-15443	79	20	𝑡𝐷	𝑡𝐷	NOUN
cet-15443	79	21	(	(	PUNCT
cet-15443	79	22	square	square	ADJ
cet-15443	79	23	symbol	symbol	NOUN
cet-15443	79	24	)	)	PUNCT
cet-15443	79	25	;	;	PUNCT
cet-15443	80	1	b	b	X
cet-15443	80	2	)	)	PUNCT
cet-15443	80	3	on	on	ADP
cet-15443	80	4	the	the	DET
cet-15443	80	5	left	left	ADJ
cet-15443	80	6	scale	scale	NOUN
cet-15443	80	7	simulated	simulate	VERB
cet-15443	80	8	temporal	temporal	ADJ
cet-15443	80	9	profiles	profile	NOUN
cet-15443	80	10	of	of	ADP
cet-15443	80	11	me	i	PRON
cet-15443	80	12	,	,	PUNCT
cet-15443	80	13	ma	ma	PROPN
cet-15443	80	14	and	and	CCONJ
cet-15443	80	15	mb	mb	ADP
cet-15443	80	16	active	active	ADJ
cet-15443	80	17	complexes	complex	NOUN
cet-15443	80	18	and	and	CCONJ
cet-15443	80	19	on	on	ADP
cet-15443	80	20	the	the	DET
cet-15443	80	21	right	right	ADJ
cet-15443	80	22	scale	scale	NOUN
cet-15443	80	23	simulated	simulate	VERB
cet-15443	80	24	sum	sum	NOUN
cet-15443	80	25	of	of	ADP
cet-15443	80	26	md	md	PROPN
cet-15443	80	27	active	active	ADJ
cet-15443	80	28	and	and	CCONJ
cet-15443	80	29	mdp27	mdp27	PROPN
cet-15443	80	30	inhibited	inhibit	VERB
cet-15443	80	31	by	by	ADP
cet-15443	80	32	p21	p21	NOUN
cet-15443	80	33	/	/	SYM
cet-15443	80	34	p27	p27	NOUN
cet-15443	80	35	complexes	complex	NOUN
cet-15443	80	36	.	.	PUNCT
cet-15443	81	1	4	4	X
cet-15443	81	2	.	.	X
cet-15443	81	3	conclusions	conclusion	NOUN
cet-15443	81	4	the	the	DET
cet-15443	81	5	alterations	alteration	NOUN
cet-15443	81	6	induced	induce	VERB
cet-15443	81	7	in	in	ADP
cet-15443	81	8	the	the	DET
cet-15443	81	9	cell	cell	NOUN
cet-15443	81	10	cycle	cycle	NOUN
cet-15443	81	11	under	under	ADP
cet-15443	81	12	microgravity	microgravity	NOUN
cet-15443	81	13	conditions	condition	NOUN
cet-15443	81	14	were	be	AUX
cet-15443	81	15	simulated	simulate	VERB
cet-15443	81	16	by	by	ADP
cet-15443	81	17	increasing	increase	VERB
cet-15443	81	18	the	the	DET
cet-15443	81	19	basal	basal	ADJ
cet-15443	81	20	production	production	NOUN
cet-15443	81	21	rate	rate	NOUN
cet-15443	81	22	of	of	ADP
cet-15443	81	23	inhibitor	inhibitor	NOUN
cet-15443	81	24	proteins	protein	NOUN
cet-15443	81	25	p21	p21	NOUN
cet-15443	81	26	and	and	CCONJ
cet-15443	81	27	p27	p27	NOUN
cet-15443	81	28	.	.	PUNCT
cet-15443	82	1	this	this	DET
cet-15443	82	2	analysis	analysis	NOUN
cet-15443	82	3	was	be	AUX
cet-15443	82	4	performed	perform	VERB
cet-15443	82	5	to	to	PART
cet-15443	82	6	assess	assess	VERB
cet-15443	82	7	the	the	DET
cet-15443	82	8	effect	effect	NOUN
cet-15443	82	9	of	of	ADP
cet-15443	82	10	an	an	DET
cet-15443	82	11	overexpression	overexpression	NOUN
cet-15443	82	12	of	of	ADP
cet-15443	82	13	p21	p21	NOUN
cet-15443	82	14	observed	observe	VERB
cet-15443	82	15	in	in	ADP
cet-15443	82	16	cell	cell	NOUN
cet-15443	82	17	cultures	culture	NOUN
cet-15443	82	18	exposed	expose	VERB
cet-15443	82	19	to	to	ADP
cet-15443	82	20	microgravity	microgravity	NOUN
cet-15443	82	21	condition	condition	NOUN
cet-15443	82	22	by	by	ADP
cet-15443	82	23	random	random	ADJ
cet-15443	82	24	positioning	positioning	NOUN
cet-15443	82	25	0	0	NUM
cet-15443	82	26	2	2	NUM
cet-15443	82	27	4	4	NUM
cet-15443	82	28	6	6	NUM
cet-15443	82	29	8	8	NUM
cet-15443	82	30	10	10	NUM
cet-15443	82	31	12	12	NUM
cet-15443	82	32	14	14	NUM
cet-15443	82	33	16	16	NUM
cet-15443	82	34	18	18	NUM
cet-15443	82	35	20	20	NUM
cet-15443	82	36	22	22	NUM
cet-15443	82	37	24	24	NUM
cet-15443	82	38	26	26	NUM
cet-15443	82	39	28	28	NUM
cet-15443	82	40	0.0	0.0	NUM
cet-15443	82	41	0.8	0.8	NUM
cet-15443	82	42	1.6	1.6	NUM
cet-15443	82	43	2.4	2.4	NUM
cet-15443	82	44	3.2	3.2	NUM
cet-15443	82	45	4.0	4.0	NUM
cet-15443	82	46	4.8	4.8	NUM
cet-15443	82	47	n	n	NOUN
cet-15443	82	48	s	s	NOUN
cet-15443	82	49	1	1	NUM
cet-15443	82	50	p	p	NOUN
cet-15443	82	51	2	2	NUM
cet-15443	82	52	7	7	NUM
cet-15443	82	53	[	[	PUNCT
cet-15443	82	54	m	m	VERB
cet-15443	82	55	m	m	VERB
cet-15443	82	56	h	h	NOUN
cet-15443	82	57	-1	-1	X
cet-15443	82	58	]	]	PUNCT
cet-15443	83	1	time	time	NOUN
cet-15443	83	2	[	[	X
cet-15443	83	3	d	d	X
cet-15443	83	4	]	]	X
cet-15443	83	5	0	0	NUM
cet-15443	83	6	24	24	NUM
cet-15443	83	7	48	48	NUM
cet-15443	83	8	72	72	NUM
cet-15443	83	9	96	96	NUM
cet-15443	83	10	120	120	NUM
cet-15443	83	11	t	t	NOUN
cet-15443	84	1	d	d	X
cet-15443	84	2	(	(	PUNCT
cet-15443	84	3	h	h	NOUN
cet-15443	84	4	)	)	PUNCT
cet-15443	84	5	0	0	NUM
cet-15443	85	1	2	2	NUM
cet-15443	85	2	4	4	NUM
cet-15443	85	3	6	6	NUM
cet-15443	85	4	8	8	NUM
cet-15443	85	5	22	22	NUM
cet-15443	85	6	24	24	NUM
cet-15443	85	7	0.0	0.0	NUM
cet-15443	85	8	0.2	0.2	NUM
cet-15443	85	9	0.4	0.4	NUM
cet-15443	85	10	0.6	0.6	NUM
cet-15443	85	11	0.8	0.8	NUM
cet-15443	85	12	1.0	1.0	NUM
cet-15443	85	13	1.2	1.2	NUM
cet-15443	85	14	1.4	1.4	NUM
cet-15443	85	15	g2	g2	PROPN
cet-15443	85	16	m	m	VERB
cet-15443	85	17	e	e	NOUN
cet-15443	85	18	,	,	PUNCT
cet-15443	85	19	m	m	VERB
cet-15443	85	20	a	a	PRON
cet-15443	85	21	,	,	PUNCT
cet-15443	85	22	m	m	PROPN
cet-15443	85	23	b	b	X
cet-15443	85	24	[	[	PUNCT
cet-15443	85	25	m	m	VERB
cet-15443	85	26	m	m	VERB
cet-15443	85	27	]	]	X
cet-15443	85	28	time	time	NOUN
cet-15443	86	1	[	[	X
cet-15443	86	2	d	d	X
cet-15443	86	3	]	]	X
cet-15443	86	4	g1	g1	X
cet-15443	86	5	/	/	SYM
cet-15443	86	6	s	s	NOUN
cet-15443	86	7	s	s	NOUN
cet-15443	86	8	m	m	PROPN
cet-15443	86	9	1.0	1.0	NUM
cet-15443	86	10	1.1	1.1	NUM
cet-15443	86	11	1.2	1.2	NUM
cet-15443	86	12	1.3	1.3	NUM
cet-15443	86	13	1.4	1.4	NUM
cet-15443	86	14	1.5	1.5	NUM
cet-15443	86	15	m	m	NOUN
cet-15443	86	16	d	d	NOUN
cet-15443	87	1	+	+	NOUN
cet-15443	87	2	m	m	VERB
cet-15443	87	3	d	d	NOUN
cet-15443	87	4	p	p	VERB
cet-15443	87	5	2	2	NUM
cet-15443	87	6	7	7	NUM
cet-15443	88	1	[	[	X
cet-15443	88	2	m	m	VERB
cet-15443	88	3	m	m	VERB
cet-15443	88	4	]	]	X
cet-15443	88	5	0	0	NUM
cet-15443	88	6	2	2	NUM
cet-15443	88	7	4	4	NUM
cet-15443	88	8	6	6	NUM
cet-15443	88	9	8	8	NUM
cet-15443	88	10	10	10	NUM
cet-15443	88	11	12	12	NUM
cet-15443	88	12	14	14	NUM
cet-15443	88	13	16	16	NUM
cet-15443	88	14	18	18	NUM
cet-15443	88	15	20	20	NUM
cet-15443	88	16	0.0	0.0	NUM
cet-15443	88	17	0.8	0.8	NUM
cet-15443	88	18	1.6	1.6	NUM
cet-15443	88	19	2.4	2.4	NUM
cet-15443	88	20	3.2	3.2	NUM
cet-15443	88	21	4.0	4.0	NUM
cet-15443	88	22	4.8	4.8	NUM
cet-15443	88	23	n	n	NOUN
cet-15443	88	24	s	s	NOUN
cet-15443	88	25	1	1	NUM
cet-15443	88	26	p	p	NOUN
cet-15443	88	27	2	2	NUM
cet-15443	88	28	7	7	NUM
cet-15443	88	29	[	[	PUNCT
cet-15443	88	30	m	m	VERB
cet-15443	88	31	m	m	VERB
cet-15443	88	32	h	h	NOUN
cet-15443	88	33	-1	-1	X
cet-15443	88	34	]	]	PUNCT
cet-15443	88	35	time	time	NOUN
cet-15443	89	1	[	[	X
cet-15443	89	2	d	d	X
cet-15443	89	3	]	]	X
cet-15443	89	4	0	0	NUM
cet-15443	89	5	24	24	NUM
cet-15443	89	6	48	48	NUM
cet-15443	89	7	72	72	NUM
cet-15443	89	8	96	96	NUM
cet-15443	89	9	120	120	NUM
cet-15443	89	10	td	td	NOUN
cet-15443	89	11	[	[	X
cet-15443	89	12	h	h	X
cet-15443	89	13	]	]	X
cet-15443	89	14	0.0	0.0	NUM
cet-15443	89	15	0.5	0.5	NUM
cet-15443	89	16	1.0	1.0	NUM
cet-15443	89	17	1.5	1.5	NUM
cet-15443	89	18	16	16	NUM
cet-15443	89	19	17	17	NUM
cet-15443	89	20	18	18	NUM
cet-15443	89	21	19	19	NUM
cet-15443	89	22	20	20	NUM
cet-15443	89	23	0.0	0.0	NUM
cet-15443	89	24	0.2	0.2	NUM
cet-15443	89	25	0.4	0.4	NUM
cet-15443	89	26	0.6	0.6	NUM
cet-15443	89	27	0.8	0.8	NUM
cet-15443	89	28	1.0	1.0	NUM
cet-15443	89	29	1.2	1.2	NUM
cet-15443	89	30	1.4	1.4	NUM
cet-15443	89	31	m	m	NOUN
cet-15443	89	32	e	e	NOUN
cet-15443	89	33	,	,	PUNCT
cet-15443	89	34	m	m	VERB
cet-15443	89	35	a	a	PRON
cet-15443	89	36	,	,	PUNCT
cet-15443	89	37	m	m	PROPN
cet-15443	89	38	b	b	X
cet-15443	89	39	[	[	PUNCT
cet-15443	89	40	m	m	VERB
cet-15443	89	41	m	m	VERB
cet-15443	89	42	]	]	X
cet-15443	89	43	time	time	NOUN
cet-15443	90	1	[	[	X
cet-15443	90	2	d	d	X
cet-15443	90	3	]	]	X
cet-15443	90	4	mg1	mg1	PROPN
cet-15443	90	5	g2	g2	PROPN
cet-15443	90	6	s	s	PART
cet-15443	90	7	1.0	1.0	NUM
cet-15443	90	8	1.1	1.1	NUM
cet-15443	90	9	1.2	1.2	NUM
cet-15443	90	10	1.3	1.3	NUM
cet-15443	90	11	1.4	1.4	NUM
cet-15443	90	12	1.5	1.5	NUM
cet-15443	90	13	m	m	NOUN
cet-15443	90	14	d	d	NOUN
cet-15443	90	15	+	+	NOUN
cet-15443	90	16	m	m	VERB
cet-15443	90	17	d	d	NOUN
cet-15443	90	18	p	p	VERB
cet-15443	90	19	2	2	NUM
cet-15443	90	20	7	7	NUM
cet-15443	90	21	[	[	X
cet-15443	90	22	m	m	VERB
cet-15443	90	23	m	m	VERB
cet-15443	90	24	]	]	X
cet-15443	90	25	(	(	PUNCT
cet-15443	90	26	a	a	NOUN
cet-15443	90	27	)	)	PUNCT
cet-15443	90	28	(	(	PUNCT
cet-15443	90	29	b	b	X
cet-15443	90	30	)	)	PUNCT
cet-15443	90	31	(	(	PUNCT
cet-15443	90	32	a	a	X
cet-15443	90	33	)	)	PUNCT
cet-15443	90	34	(	(	PUNCT
cet-15443	90	35	b	b	NOUN
cet-15443	90	36	)	)	PUNCT
cet-15443	90	37	1157	1157	NUM
cet-15443	90	38	machine	machine	NOUN
cet-15443	90	39	(	(	PUNCT
cet-15443	90	40	rpm	rpm	PROPN
cet-15443	90	41	)	)	PUNCT
cet-15443	90	42	.	.	PUNCT
cet-15443	91	1	a	a	DET
cet-15443	91	2	previously	previously	ADV
cet-15443	91	3	developed	develop	VERB
cet-15443	91	4	kinetic	kinetic	ADJ
cet-15443	91	5	model	model	NOUN
cet-15443	91	6	was	be	AUX
cet-15443	91	7	employed	employ	VERB
cet-15443	91	8	to	to	PART
cet-15443	91	9	estimate	estimate	VERB
cet-15443	91	10	cell	cell	NOUN
cet-15443	91	11	duplication	duplication	NOUN
cet-15443	91	12	time	time	NOUN
cet-15443	91	13	under	under	ADP
cet-15443	91	14	both	both	DET
cet-15443	91	15	earth	earth	NOUN
cet-15443	91	16	and	and	CCONJ
cet-15443	91	17	microgravity	microgravity	NOUN
cet-15443	91	18	conditions	condition	NOUN
cet-15443	91	19	.	.	PUNCT
cet-15443	92	1	this	this	DET
cet-15443	92	2	model	model	NOUN
cet-15443	92	3	enabled	enable	VERB
cet-15443	92	4	a	a	DET
cet-15443	92	5	detailed	detailed	ADJ
cet-15443	92	6	investigation	investigation	NOUN
cet-15443	92	7	of	of	ADP
cet-15443	92	8	how	how	SCONJ
cet-15443	92	9	microgravity	microgravity	NOUN
cet-15443	92	10	impacts	impact	VERB
cet-15443	92	11	cell	cell	NOUN
cet-15443	92	12	cycle	cycle	NOUN
cet-15443	92	13	dynamics	dynamic	NOUN
cet-15443	92	14	.	.	PUNCT
cet-15443	93	1	a	a	DET
cet-15443	93	2	series	series	NOUN
cet-15443	93	3	of	of	ADP
cet-15443	93	4	simulations	simulation	NOUN
cet-15443	93	5	were	be	AUX
cet-15443	93	6	conducted	conduct	VERB
cet-15443	93	7	by	by	ADP
cet-15443	93	8	incrementally	incrementally	ADV
cet-15443	93	9	varying	vary	VERB
cet-15443	93	10	the	the	DET
cet-15443	93	11	basal	basal	ADJ
cet-15443	93	12	production	production	NOUN
cet-15443	93	13	rate	rate	NOUN
cet-15443	93	14	of	of	ADP
cet-15443	93	15	p21	p21	NOUN
cet-15443	93	16	/	/	SYM
cet-15443	93	17	p27	p27	NOUN
cet-15443	93	18	mirroring	mirroring	NOUN
cet-15443	93	19	microgravity	microgravity	NOUN
cet-15443	93	20	conditions	condition	NOUN
cet-15443	93	21	.	.	PUNCT
cet-15443	94	1	the	the	DET
cet-15443	94	2	results	result	NOUN
cet-15443	94	3	align	align	VERB
cet-15443	94	4	well	well	ADV
cet-15443	94	5	with	with	ADP
cet-15443	94	6	experimental	experimental	ADJ
cet-15443	94	7	observations	observation	NOUN
cet-15443	94	8	reported	report	VERB
cet-15443	94	9	by	by	ADP
cet-15443	94	10	coinu	coinu	NOUN
cet-15443	94	11	and	and	CCONJ
cet-15443	94	12	colleagues	colleague	NOUN
cet-15443	94	13	,	,	PUNCT
cet-15443	94	14	demonstrating	demonstrate	VERB
cet-15443	94	15	that	that	SCONJ
cet-15443	94	16	duplication	duplication	NOUN
cet-15443	94	17	time	time	NOUN
cet-15443	94	18	increases	increase	VERB
cet-15443	94	19	progressively	progressively	ADV
cet-15443	94	20	to	to	PART
cet-15443	94	21	ultimately	ultimately	ADV
cet-15443	94	22	arrest	arrest	VERB
cet-15443	94	23	at	at	ADP
cet-15443	94	24	higher	high	ADJ
cet-15443	94	25	levels	level	NOUN
cet-15443	94	26	of	of	ADP
cet-15443	94	27	inhibitor	inhibitor	NOUN
cet-15443	94	28	protein	protein	NOUN
cet-15443	94	29	expression	expression	NOUN
cet-15443	94	30	(	(	PUNCT
cet-15443	94	31	to	to	ADP
cet-15443	94	32	the	the	DET
cet-15443	94	33	best	good	ADJ
cet-15443	94	34	of	of	ADP
cet-15443	94	35	authors	author	NOUN
cet-15443	94	36	’	’	PART
cet-15443	94	37	knowledge	knowledge	NOUN
cet-15443	94	38	no	no	DET
cet-15443	94	39	other	other	ADJ
cet-15443	94	40	data	datum	NOUN
cet-15443	94	41	are	be	AUX
cet-15443	94	42	available	available	ADJ
cet-15443	94	43	in	in	ADP
cet-15443	94	44	the	the	DET
cet-15443	94	45	literature	literature	NOUN
cet-15443	94	46	to	to	PART
cet-15443	94	47	further	far	ADV
cet-15443	94	48	validate	validate	VERB
cet-15443	94	49	the	the	DET
cet-15443	94	50	proposed	propose	VERB
cet-15443	94	51	model	model	NOUN
cet-15443	94	52	)	)	PUNCT
cet-15443	94	53	.	.	PUNCT
cet-15443	95	1	these	these	DET
cet-15443	95	2	findings	finding	NOUN
cet-15443	95	3	highlight	highlight	VERB
cet-15443	95	4	the	the	DET
cet-15443	95	5	significant	significant	ADJ
cet-15443	95	6	impact	impact	NOUN
cet-15443	95	7	of	of	ADP
cet-15443	95	8	microgravity	microgravity	NOUN
cet-15443	95	9	on	on	ADP
cet-15443	95	10	cellular	cellular	ADJ
cet-15443	95	11	replication	replication	NOUN
cet-15443	95	12	processes	process	NOUN
cet-15443	95	13	.	.	PUNCT
cet-15443	96	1	although	although	SCONJ
cet-15443	96	2	the	the	DET
cet-15443	96	3	results	result	NOUN
cet-15443	96	4	are	be	AUX
cet-15443	96	5	promising	promise	VERB
cet-15443	96	6	,	,	PUNCT
cet-15443	96	7	the	the	DET
cet-15443	96	8	parameters	parameter	NOUN
cet-15443	96	9	used	use	VERB
cet-15443	96	10	in	in	ADP
cet-15443	96	11	the	the	DET
cet-15443	96	12	model	model	NOUN
cet-15443	96	13	were	be	AUX
cet-15443	96	14	derived	derive	VERB
cet-15443	96	15	from	from	ADP
cet-15443	96	16	literature	literature	NOUN
cet-15443	96	17	and	and	CCONJ
cet-15443	96	18	have	have	AUX
cet-15443	96	19	not	not	PART
cet-15443	96	20	yet	yet	ADV
cet-15443	96	21	been	be	AUX
cet-15443	96	22	rigorously	rigorously	ADV
cet-15443	96	23	validated	validate	VERB
cet-15443	96	24	with	with	ADP
cet-15443	96	25	specific	specific	ADJ
cet-15443	96	26	experimental	experimental	ADJ
cet-15443	96	27	data	datum	NOUN
cet-15443	96	28	.	.	PUNCT
cet-15443	97	1	with	with	SCONJ
cet-15443	97	2	the	the	DET
cet-15443	97	3	model	model	NOUN
cet-15443	97	4	parameters	parameter	NOUN
cet-15443	97	5	fine	fine	ADV
cet-15443	97	6	-	-	PUNCT
cet-15443	97	7	tuned	tune	VERB
cet-15443	97	8	for	for	ADP
cet-15443	97	9	particular	particular	ADJ
cet-15443	97	10	cell	cell	NOUN
cet-15443	97	11	lines	line	NOUN
cet-15443	97	12	,	,	PUNCT
cet-15443	97	13	numerical	numerical	ADJ
cet-15443	97	14	simulations	simulation	NOUN
cet-15443	97	15	could	could	AUX
cet-15443	97	16	provide	provide	VERB
cet-15443	97	17	valuable	valuable	ADJ
cet-15443	97	18	insights	insight	NOUN
cet-15443	97	19	into	into	ADP
cet-15443	97	20	the	the	DET
cet-15443	97	21	quality	quality	NOUN
cet-15443	97	22	of	of	ADP
cet-15443	97	23	cells	cell	NOUN
cet-15443	97	24	post	post	ADJ
cet-15443	97	25	-	-	NOUN
cet-15443	97	26	duplication	duplication	NOUN
cet-15443	97	27	under	under	ADP
cet-15443	97	28	both	both	CCONJ
cet-15443	97	29	terrestrial	terrestrial	ADJ
cet-15443	97	30	gravity	gravity	NOUN
cet-15443	97	31	and	and	CCONJ
cet-15443	97	32	microgravity	microgravity	NOUN
cet-15443	97	33	.	.	PUNCT
cet-15443	98	1	such	such	ADJ
cet-15443	98	2	simulations	simulation	NOUN
cet-15443	98	3	could	could	AUX
cet-15443	98	4	help	help	AUX
cet-15443	98	5	identify	identify	VERB
cet-15443	98	6	whether	whether	SCONJ
cet-15443	98	7	cell	cell	NOUN
cet-15443	98	8	division	division	NOUN
cet-15443	98	9	occurs	occur	VERB
cet-15443	98	10	“	"	PUNCT
cet-15443	98	11	normally	normally	ADV
cet-15443	98	12	”	"	PUNCT
cet-15443	98	13	or	or	CCONJ
cet-15443	98	14	if	if	SCONJ
cet-15443	98	15	cells	cell	NOUN
cet-15443	98	16	exhibit	exhibit	VERB
cet-15443	98	17	anomalies	anomaly	NOUN
cet-15443	98	18	such	such	ADJ
cet-15443	98	19	as	as	ADP
cet-15443	98	20	endoreplication	endoreplication	NOUN
cet-15443	98	21	,	,	PUNCT
cet-15443	98	22	tetraploidy	tetraploidy	ADJ
cet-15443	98	23	,	,	PUNCT
cet-15443	98	24	or	or	CCONJ
cet-15443	98	25	other	other	ADJ
cet-15443	98	26	replication	replication	NOUN
cet-15443	98	27	-	-	PUNCT
cet-15443	98	28	related	relate	VERB
cet-15443	98	29	abnormalities	abnormality	NOUN
cet-15443	98	30	.	.	PUNCT
cet-15443	99	1	this	this	DET
cet-15443	99	2	approach	approach	NOUN
cet-15443	99	3	has	have	VERB
cet-15443	99	4	the	the	DET
cet-15443	99	5	potential	potential	NOUN
cet-15443	99	6	to	to	PART
cet-15443	99	7	enhance	enhance	VERB
cet-15443	99	8	our	our	PRON
cet-15443	99	9	understanding	understanding	NOUN
cet-15443	99	10	of	of	ADP
cet-15443	99	11	cellular	cellular	ADJ
cet-15443	99	12	responses	response	NOUN
cet-15443	99	13	to	to	ADP
cet-15443	99	14	microgravity	microgravity	NOUN
cet-15443	99	15	,	,	PUNCT
cet-15443	99	16	paving	pave	VERB
cet-15443	99	17	the	the	DET
cet-15443	99	18	way	way	NOUN
cet-15443	99	19	for	for	ADP
cet-15443	99	20	applications	application	NOUN
cet-15443	99	21	in	in	ADP
cet-15443	99	22	space	space	NOUN
cet-15443	99	23	biology	biology	NOUN
cet-15443	99	24	,	,	PUNCT
cet-15443	99	25	regenerative	regenerative	ADJ
cet-15443	99	26	medicine	medicine	NOUN
cet-15443	99	27	,	,	PUNCT
cet-15443	99	28	and	and	CCONJ
cet-15443	99	29	cancer	cancer	NOUN
cet-15443	99	30	research	research	NOUN
cet-15443	99	31	.	.	PUNCT
cet-15443	100	1	by	by	ADP
cet-15443	100	2	refining	refine	VERB
cet-15443	100	3	the	the	DET
cet-15443	100	4	model	model	NOUN
cet-15443	100	5	and	and	CCONJ
cet-15443	100	6	incorporating	incorporate	VERB
cet-15443	100	7	experimental	experimental	ADJ
cet-15443	100	8	validation	validation	NOUN
cet-15443	100	9	,	,	PUNCT
cet-15443	100	10	these	these	DET
cet-15443	100	11	simulations	simulation	NOUN
cet-15443	100	12	may	may	AUX
cet-15443	100	13	also	also	ADV
cet-15443	100	14	serve	serve	VERB
cet-15443	100	15	as	as	ADP
cet-15443	100	16	predictive	predictive	ADJ
cet-15443	100	17	tools	tool	NOUN
cet-15443	100	18	for	for	ADP
cet-15443	100	19	assessing	assess	VERB
cet-15443	100	20	cellular	cellular	ADJ
cet-15443	100	21	health	health	NOUN
cet-15443	100	22	and	and	CCONJ
cet-15443	100	23	function	function	NOUN
cet-15443	100	24	in	in	ADP
cet-15443	100	25	altered	altered	ADJ
cet-15443	100	26	gravitational	gravitational	ADJ
cet-15443	100	27	environments	environment	NOUN
cet-15443	100	28	.	.	PUNCT
cet-15443	101	1	nomenclature	nomenclature	NOUN
cet-15443	101	2	c	c	NOUN
cet-15443	101	3	–	–	PUNCT
cet-15443	101	4	generical	generical	ADJ
cet-15443	101	5	species	specie	NOUN
cet-15443	101	6	,	,	PUNCT
cet-15443	101	7	µm	µm	ADP
cet-15443	101	8	g0	g0	ADJ
cet-15443	101	9	–	–	PUNCT
cet-15443	101	10	gap	gap	NOUN
cet-15443	101	11	0	0	NUM
cet-15443	101	12	,	,	PUNCT
cet-15443	101	13	resting	rest	VERB
cet-15443	101	14	phase	phase	NOUN
cet-15443	101	15	,	,	PUNCT
cet-15443	101	16	g1	g1	PROPN
cet-15443	101	17	–	–	PUNCT
cet-15443	101	18	gap	gap	NOUN
cet-15443	101	19	1	1	NUM
cet-15443	101	20	,	,	PUNCT
cet-15443	101	21	initial	initial	ADJ
cet-15443	101	22	cell	cell	NOUN
cet-15443	101	23	growth	growth	NOUN
cet-15443	101	24	phase	phase	NOUN
cet-15443	101	25	,	,	PUNCT
cet-15443	101	26	g2	g2	PROPN
cet-15443	101	27	–	–	PUNCT
cet-15443	101	28	gap	gap	NOUN
cet-15443	101	29	2	2	NUM
cet-15443	101	30	,	,	PUNCT
cet-15443	101	31	second	second	ADJ
cet-15443	101	32	cell	cell	NOUN
cet-15443	101	33	growth	growth	NOUN
cet-15443	101	34	phase	phase	NOUN
cet-15443	101	35	,	,	PUNCT
cet-15443	101	36	𝑘𝑑	𝑘𝑑	INTJ
cet-15443	101	37	–	–	PUNCT
cet-15443	101	38	degradation	degradation	NOUN
cet-15443	101	39	kinetic	kinetic	NOUN
cet-15443	101	40	rate	rate	NOUN
cet-15443	101	41	constant	constant	ADJ
cet-15443	101	42	,	,	PUNCT
cet-15443	101	43	h-1	h-1	NUM
cet-15443	101	44	m	m	PROPN
cet-15443	101	45	–	–	PUNCT
cet-15443	101	46	mitosis	mitosis	NOUN
cet-15443	101	47	,	,	PUNCT
cet-15443	101	48	cell	cell	NOUN
cet-15443	101	49	division	division	NOUN
cet-15443	101	50	,	,	PUNCT
cet-15443	101	51	ma	ma	PROPN
cet-15443	101	52	–	–	PUNCT
cet-15443	101	53	activate	activate	VERB
cet-15443	101	54	cyclin	cyclin	PROPN
cet-15443	101	55	/	/	SYM
cet-15443	101	56	cdk	cdk	PROPN
cet-15443	101	57	complex	complex	NOUN
cet-15443	101	58	a	a	DET
cet-15443	101	59	/	/	SYM
cet-15443	101	60	cdk2	cdk2	NOUN
cet-15443	101	61	,	,	PUNCT
cet-15443	101	62	µm	µm	ADP
cet-15443	101	63	mb	mb	PROPN
cet-15443	101	64	–	–	PUNCT
cet-15443	101	65	activate	activate	VERB
cet-15443	101	66	cyclin	cyclin	PROPN
cet-15443	101	67	/	/	SYM
cet-15443	101	68	cdk	cdk	PROPN
cet-15443	101	69	complex	complex	PROPN
cet-15443	101	70	b	b	X
cet-15443	101	71	/	/	SYM
cet-15443	101	72	cdk1	cdk1	PROPN
cet-15443	101	73	,	,	PUNCT
cet-15443	101	74	µm	µm	ADP
cet-15443	101	75	md	md	PROPN
cet-15443	101	76	–	–	PUNCT
cet-15443	101	77	activate	activate	VERB
cet-15443	101	78	cyclin	cyclin	PROPN
cet-15443	101	79	/	/	SYM
cet-15443	101	80	cdk	cdk	PROPN
cet-15443	101	81	complex	complex	ADJ
cet-15443	101	82	d	d	PROPN
cet-15443	101	83	/	/	SYM
cet-15443	101	84	ckd4	ckd4	PROPN
cet-15443	101	85	-	-	PUNCT
cet-15443	101	86	6	6	NUM
cet-15443	101	87	,	,	PUNCT
cet-15443	101	88	µm	µm	ADP
cet-15443	101	89	mdp27	mdp27	PROPN
cet-15443	101	90	–	–	PUNCT
cet-15443	101	91	md	md	PROPN
cet-15443	101	92	inhibited	inhibit	VERB
cet-15443	101	93	by	by	ADP
cet-15443	101	94	p21	p21	PROPN
cet-15443	101	95	/	/	SYM
cet-15443	101	96	p27	p27	PROPN
cet-15443	101	97	,	,	PUNCT
cet-15443	101	98	µm	µm	ADP
cet-15443	101	99	me	i	PRON
cet-15443	101	100	–	–	PUNCT
cet-15443	101	101	activate	activate	VERB
cet-15443	101	102	cyclin	cyclin	PROPN
cet-15443	101	103	/	/	SYM
cet-15443	101	104	cdk	cdk	PROPN
cet-15443	101	105	complex	complex	PROPN
cet-15443	101	106	e	e	PROPN
cet-15443	101	107	/	/	SYM
cet-15443	101	108	cdk2	cdk2	PROPN
cet-15443	101	109	,	,	PUNCT
cet-15443	101	110	µm	µm	ADP
cet-15443	101	111	p21	p21	NOUN
cet-15443	101	112	/	/	SYM
cet-15443	101	113	p27	p27	PROPN
cet-15443	101	114	–	–	PUNCT
cet-15443	101	115	inhibitor	inhibitor	NOUN
cet-15443	101	116	proteins	protein	NOUN
cet-15443	101	117	,	,	PUNCT
cet-15443	101	118	µm	µm	X
cet-15443	101	119	rpm	rpm	NOUN
cet-15443	101	120	–	–	PUNCT
cet-15443	101	121	random	random	ADJ
cet-15443	101	122	positioning	positioning	NOUN
cet-15443	101	123	machine	machine	NOUN
cet-15443	101	124	,	,	PUNCT
cet-15443	101	125	𝑟𝑝𝑟𝑜	𝑟𝑝𝑟𝑜	PROPN
cet-15443	101	126	–	–	PUNCT
cet-15443	101	127	generical	generical	ADJ
cet-15443	101	128	promoting	promote	VERB
cet-15443	101	129	effect	effect	NOUN
cet-15443	101	130	rate	rate	NOUN
cet-15443	101	131	,	,	PUNCT
cet-15443	101	132	μm	μm	NOUN
cet-15443	101	133	h-1	h-1	ADJ
cet-15443	101	134	𝑟𝑖𝑛ℎ𝑖	𝑟𝑖𝑛ℎ𝑖	NOUN
cet-15443	101	135	–	–	PUNCT
cet-15443	101	136	generical	generical	ADJ
cet-15443	101	137	inhibition	inhibition	NOUN
cet-15443	101	138	effect	effect	NOUN
cet-15443	101	139	rate	rate	NOUN
cet-15443	101	140	,	,	PUNCT
cet-15443	101	141	μm	μm	INTJ
cet-15443	101	142	h-1	h-1	NOUN
cet-15443	101	143	s	s	PART
cet-15443	101	144	–	–	PUNCT
cet-15443	101	145	synthesis	synthesis	NOUN
cet-15443	101	146	,	,	PUNCT
cet-15443	101	147	dna	dna	NOUN
cet-15443	101	148	duplication	duplication	NOUN
cet-15443	101	149	phase	phase	NOUN
cet-15443	101	150	,	,	PUNCT
cet-15443	101	151	𝑡𝐷	𝑡𝐷	NOUN
cet-15443	101	152	–	–	PUNCT
cet-15443	101	153	duplication	duplication	NOUN
cet-15443	101	154	time	time	NOUN
cet-15443	101	155	,	,	PUNCT
cet-15443	101	156	h	h	NOUN
cet-15443	101	157	𝑣𝑏	𝑣𝑏	VERB
cet-15443	101	158	–	–	PUNCT
cet-15443	101	159	generical	generical	ADJ
cet-15443	101	160	basal	basal	NOUN
cet-15443	101	161	production	production	NOUN
cet-15443	101	162	,	,	PUNCT
cet-15443	101	163	μm	μm	NOUN
cet-15443	101	164	h-1	h-1	ADJ
cet-15443	101	165	𝑣𝑠1𝑝27	𝑣𝑠1𝑝27	PROPN
cet-15443	101	166	–	–	PUNCT
cet-15443	101	167	basal	basal	PROPN
cet-15443	101	168	p21	p21	NOUN
cet-15443	101	169	/	/	SYM
cet-15443	101	170	p27	p27	NOUN
cet-15443	101	171	production	production	NOUN
cet-15443	101	172	,	,	PUNCT
cet-15443	101	173	μm	μm	NOUN
cet-15443	101	174	h-1	h-1	ADJ
cet-15443	101	175	𝑣𝑠1𝑝27	𝑣𝑠1𝑝27	ADJ
cet-15443	101	176	𝑚𝑎𝑥	𝑚𝑎𝑥	NOUN
cet-15443	101	177	–	–	PUNCT
cet-15443	101	178	max	max	NOUN
cet-15443	101	179	value	value	NOUN
cet-15443	101	180	of	of	ADP
cet-15443	101	181	𝑣𝑠1𝑝27	𝑣𝑠1𝑝27	PROPN
cet-15443	101	182	,	,	PUNCT
cet-15443	101	183	μm	μm	NUM
cet-15443	101	184	h-1	h-1	ADJ
cet-15443	101	185	acknowledgments	acknowledgment	NOUN
cet-15443	101	186	this	this	DET
cet-15443	101	187	work	work	NOUN
cet-15443	101	188	has	have	AUX
cet-15443	101	189	been	be	AUX
cet-15443	101	190	developed	develop	VERB
cet-15443	101	191	within	within	ADP
cet-15443	101	192	the	the	DET
cet-15443	101	193	framework	framework	NOUN
cet-15443	101	194	of	of	ADP
cet-15443	101	195	the	the	DET
cet-15443	101	196	project	project	NOUN
cet-15443	101	197	e.	e.	PROPN
cet-15443	101	198	ins	ins	PROPN
cet-15443	101	199	-	-	PUNCT
cet-15443	101	200	ecosystem	ecosystem	NOUN
cet-15443	101	201	of	of	ADP
cet-15443	101	202	innovation	innovation	NOUN
cet-15443	101	203	for	for	ADP
cet-15443	101	204	next	next	ADJ
cet-15443	101	205	generation	generation	NOUN
cet-15443	101	206	sardinia	sardinia	PROPN
cet-15443	101	207	(	(	PUNCT
cet-15443	101	208	cod	cod	PROPN
cet-15443	101	209	.	.	PUNCT
cet-15443	102	1	ecs	ecs	PROPN
cet-15443	102	2	00000038	00000038	NUM
cet-15443	102	3	)	)	PUNCT
cet-15443	102	4	funded	fund	VERB
cet-15443	102	5	by	by	ADP
cet-15443	102	6	the	the	DET
cet-15443	102	7	italian	italian	PROPN
cet-15443	102	8	ministry	ministry	PROPN
cet-15443	102	9	for	for	ADP
cet-15443	102	10	research	research	NOUN
cet-15443	102	11	and	and	CCONJ
cet-15443	102	12	education	education	NOUN
cet-15443	102	13	(	(	PUNCT
cet-15443	102	14	mur	mur	PROPN
cet-15443	102	15	)	)	PUNCT
cet-15443	102	16	under	under	ADP
cet-15443	102	17	the	the	DET
cet-15443	102	18	national	national	ADJ
cet-15443	102	19	recovery	recovery	NOUN
cet-15443	102	20	and	and	CCONJ
cet-15443	102	21	resilience	resilience	NOUN
cet-15443	102	22	plan	plan	NOUN
cet-15443	102	23	(	(	PUNCT
cet-15443	102	24	nrrp)—mission	nrrp)—mission	NOUN
cet-15443	102	25	4	4	NUM
cet-15443	102	26	component	component	NOUN
cet-15443	102	27	2	2	NUM
cet-15443	102	28	,	,	PUNCT
cet-15443	102	29	“	"	PUNCT
cet-15443	102	30	from	from	ADP
cet-15443	102	31	research	research	NOUN
cet-15443	102	32	to	to	ADP
cet-15443	102	33	business	business	NOUN
cet-15443	102	34	”	"	PUNCT
cet-15443	102	35	investment	investment	NOUN
cet-15443	102	36	1.5	1.5	NUM
cet-15443	102	37	,	,	PUNCT
cet-15443	102	38	“	"	PUNCT
cet-15443	102	39	creation	creation	NOUN
cet-15443	102	40	and	and	CCONJ
cet-15443	102	41	strengthening	strengthening	NOUN
cet-15443	102	42	of	of	ADP
cet-15443	102	43	ecosystems	ecosystem	NOUN
cet-15443	102	44	of	of	ADP
cet-15443	102	45	innovation	innovation	NOUN
cet-15443	102	46	”	"	PUNCT
cet-15443	102	47	and	and	CCONJ
cet-15443	102	48	construction	construction	NOUN
cet-15443	102	49	of	of	ADP
cet-15443	102	50	“	"	PUNCT
cet-15443	102	51	territorial	territorial	ADJ
cet-15443	102	52	r&d	r&d	NOUN
cet-15443	102	53	leaders	leader	NOUN
cet-15443	102	54	”	"	PUNCT
cet-15443	102	55	.	.	PUNCT
cet-15443	103	1	references	reference	NOUN
cet-15443	103	2	coinu	coinu	NOUN
cet-15443	103	3	r.	r.	PROPN
cet-15443	103	4	,	,	PUNCT
cet-15443	103	5	chiaviello	chiaviello	PROPN
cet-15443	103	6	a.	a.	PROPN
cet-15443	103	7	,	,	PUNCT
cet-15443	103	8	galleri	galleri	PROPN
cet-15443	103	9	g.	g.	PROPN
cet-15443	103	10	,	,	PUNCT
cet-15443	103	11	franconi	franconi	PROPN
cet-15443	103	12	f.	f.	PROPN
cet-15443	103	13	,	,	PUNCT
cet-15443	103	14	crescenzi	crescenzi	PROPN
cet-15443	103	15	e.	e.	PROPN
cet-15443	103	16	,	,	PUNCT
cet-15443	103	17	palumbo	palumbo	PROPN
cet-15443	103	18	g.	g.	PROPN
cet-15443	103	19	,	,	PUNCT
cet-15443	103	20	2006	2006	NUM
cet-15443	103	21	,	,	PUNCT
cet-15443	103	22	exposure	exposure	NOUN
cet-15443	103	23	to	to	ADP
cet-15443	103	24	modeled	model	VERB
cet-15443	103	25	microgravity	microgravity	NOUN
cet-15443	103	26	induces	induce	VERB
cet-15443	103	27	metabolic	metabolic	ADJ
cet-15443	103	28	idleness	idleness	NOUN
cet-15443	103	29	in	in	ADP
cet-15443	103	30	malignant	malignant	ADJ
cet-15443	103	31	human	human	ADJ
cet-15443	103	32	mcf-7	mcf-7	PUNCT
cet-15443	103	33	and	and	CCONJ
cet-15443	103	34	normal	normal	ADJ
cet-15443	103	35	murine	murine	ADJ
cet-15443	103	36	vsmc	vsmc	NOUN
cet-15443	103	37	cells	cell	NOUN
cet-15443	103	38	,	,	PUNCT
cet-15443	103	39	febs	febs	NOUN
cet-15443	103	40	letters	letter	NOUN
cet-15443	103	41	580	580	NUM
cet-15443	103	42	,	,	PUNCT
cet-15443	103	43	2465–2470	2465–2470	NUM
cet-15443	103	44	.	.	PUNCT
cet-15443	104	1	gérard	gérard	PROPN
cet-15443	104	2	c.	c.	PROPN
cet-15443	104	3	,	,	PUNCT
cet-15443	104	4	goldbeter	goldbeter	PROPN
cet-15443	104	5	a.	a.	PROPN
cet-15443	104	6	,	,	PUNCT
cet-15443	104	7	2009	2009	NUM
cet-15443	104	8	,	,	PUNCT
cet-15443	104	9	temporal	temporal	ADJ
cet-15443	104	10	self	self	NOUN
cet-15443	104	11	-	-	PUNCT
cet-15443	104	12	organization	organization	NOUN
cet-15443	104	13	of	of	ADP
cet-15443	104	14	the	the	DET
cet-15443	104	15	cyclin	cyclin	PROPN
cet-15443	104	16	/	/	SYM
cet-15443	104	17	cdk	cdk	PROPN
cet-15443	104	18	network	network	NOUN
cet-15443	104	19	driving	drive	VERB
cet-15443	104	20	the	the	DET
cet-15443	104	21	mammalian	mammalian	ADJ
cet-15443	104	22	cell	cell	NOUN
cet-15443	104	23	cycle	cycle	NOUN
cet-15443	104	24	.	.	PUNCT
cet-15443	105	1	proc	proc	PROPN
cet-15443	105	2	.	.	PUNCT
cet-15443	106	1	natl	natl	PROPN
cet-15443	106	2	.	.	PUNCT
cet-15443	107	1	acad	acad	PROPN
cet-15443	107	2	.	.	PUNCT
cet-15443	108	1	sci	sci	PROPN
cet-15443	108	2	.	.	PUNCT
cet-15443	108	3	u.s.a	u.s.a	PROPN
cet-15443	108	4	.	.	PROPN
cet-15443	108	5	106	106	NUM
cet-15443	108	6	,	,	PUNCT
cet-15443	108	7	21643–21648	21643–21648	NUM
cet-15443	108	8	.	.	PUNCT
cet-15443	109	1	gérard	gérard	PROPN
cet-15443	109	2	c.	c.	PROPN
cet-15443	109	3	,	,	PUNCT
cet-15443	109	4	goldbeter	goldbeter	PROPN
cet-15443	109	5	a.	a.	PROPN
cet-15443	109	6	,	,	PUNCT
cet-15443	109	7	2012	2012	NUM
cet-15443	109	8	,	,	PUNCT
cet-15443	109	9	from	from	ADP
cet-15443	109	10	quiescence	quiescence	NOUN
cet-15443	109	11	to	to	ADP
cet-15443	109	12	proliferation	proliferation	NOUN
cet-15443	109	13	:	:	PUNCT
cet-15443	109	14	cdk	cdk	PROPN
cet-15443	109	15	oscillations	oscillation	NOUN
cet-15443	109	16	drive	drive	VERB
cet-15443	109	17	the	the	DET
cet-15443	109	18	mammalian	mammalian	ADJ
cet-15443	109	19	cell	cell	NOUN
cet-15443	109	20	cycle	cycle	NOUN
cet-15443	109	21	,	,	PUNCT
cet-15443	109	22	frontiers	frontier	NOUN
cet-15443	109	23	in	in	ADP
cet-15443	109	24	physiology	physiology	NOUN
cet-15443	109	25	,	,	PUNCT
cet-15443	109	26	sec	sec	PROPN
cet-15443	109	27	.	.	PROPN
cet-15443	109	28	systems	system	NOUN
cet-15443	109	29	biology	biology	NOUN
cet-15443	109	30	archive	archive	NOUN
cet-15443	109	31	,	,	PUNCT
cet-15443	109	32	volume	volume	NOUN
cet-15443	109	33	3	3	NUM
cet-15443	109	34	gérard	gérard	PROPN
cet-15443	109	35	c.	c.	PROPN
cet-15443	109	36	,	,	PUNCT
cet-15443	109	37	goldebeter	goldebeter	NOUN
cet-15443	109	38	a.	a.	PROPN
cet-15443	109	39	,	,	PUNCT
cet-15443	109	40	2014	2014	NUM
cet-15443	109	41	,	,	PUNCT
cet-15443	109	42	the	the	DET
cet-15443	109	43	balance	balance	NOUN
cet-15443	109	44	between	between	ADP
cet-15443	109	45	cell	cell	NOUN
cet-15443	109	46	cycle	cycle	NOUN
cet-15443	109	47	arrest	arrest	NOUN
cet-15443	109	48	and	and	CCONJ
cet-15443	109	49	cell	cell	NOUN
cet-15443	109	50	proliferation	proliferation	NOUN
cet-15443	109	51	:	:	PUNCT
cet-15443	109	52	control	control	NOUN
cet-15443	109	53	by	by	ADP
cet-15443	109	54	the	the	DET
cet-15443	109	55	extracellular	extracellular	ADJ
cet-15443	109	56	matrix	matrix	NOUN
cet-15443	109	57	and	and	CCONJ
cet-15443	109	58	by	by	ADP
cet-15443	109	59	contact	contact	NOUN
cet-15443	109	60	inhibition	inhibition	NOUN
cet-15443	109	61	.	.	PUNCT
cet-15443	110	1	interface	interface	NOUN
cet-15443	110	2	focus	focus	VERB
cet-15443	110	3	4	4	NUM
cet-15443	110	4	:	:	SYM
cet-15443	110	5	20130075	20130075	NUM
cet-15443	110	6	.	.	PUNCT
cet-15443	111	1	pisu	pisu	NOUN
cet-15443	111	2	m.	m.	NOUN
cet-15443	111	3	,	,	PUNCT
cet-15443	111	4	concas	concas	PROPN
cet-15443	111	5	a.	a.	PROPN
cet-15443	111	6	,	,	PUNCT
cet-15443	111	7	cao	cao	PROPN
cet-15443	111	8	g.	g.	PROPN
cet-15443	111	9	,	,	PUNCT
cet-15443	111	10	2015	2015	NUM
cet-15443	111	11	,	,	PUNCT
cet-15443	111	12	a	a	DET
cet-15443	111	13	novel	novel	ADJ
cet-15443	111	14	quantitative	quantitative	ADJ
cet-15443	111	15	model	model	NOUN
cet-15443	111	16	of	of	ADP
cet-15443	111	17	cell	cell	NOUN
cet-15443	111	18	cycle	cycle	NOUN
cet-15443	111	19	progression	progression	NOUN
cet-15443	111	20	based	base	VERB
cet-15443	111	21	on	on	ADP
cet-15443	111	22	cyclindependent	cyclindependent	ADJ
cet-15443	111	23	kinases	kinase	NOUN
cet-15443	111	24	activity	activity	NOUN
cet-15443	111	25	and	and	CCONJ
cet-15443	111	26	population	population	NOUN
cet-15443	111	27	balances	balance	NOUN
cet-15443	111	28	,	,	PUNCT
cet-15443	111	29	computational	computational	ADJ
cet-15443	111	30	biology	biology	NOUN
cet-15443	111	31	and	and	CCONJ
cet-15443	111	32	chemistry	chemistry	NOUN
cet-15443	111	33	55	55	NUM
cet-15443	111	34	,	,	PUNCT
cet-15443	111	35	1–13	1–13	NOUN
cet-15443	111	36	pisu	pisu	NOUN
cet-15443	111	37	m.	m.	NOUN
cet-15443	111	38	,	,	PUNCT
cet-15443	111	39	concas	concas	PROPN
cet-15443	111	40	a.	a.	PROPN
cet-15443	111	41	,	,	PUNCT
cet-15443	111	42	cao	cao	PROPN
cet-15443	111	43	g.	g.	PROPN
cet-15443	111	44	,	,	PUNCT
cet-15443	111	45	pantaleo	pantaleo	PROPN
cet-15443	111	46	a.	a.	NOUN
cet-15443	111	47	,	,	PUNCT
cet-15443	111	48	2022	2022	NUM
cet-15443	111	49	,	,	PUNCT
cet-15443	111	50	mathematical	mathematical	ADJ
cet-15443	111	51	modelling	modelling	NOUN
cet-15443	111	52	and	and	CCONJ
cet-15443	111	53	computational	computational	ADJ
cet-15443	111	54	simulation	simulation	NOUN
cet-15443	111	55	of	of	ADP
cet-15443	111	56	mammalian	mammalian	ADJ
cet-15443	111	57	cell	cell	NOUN
cet-15443	111	58	cycle	cycle	NOUN
cet-15443	111	59	progression	progression	NOUN
cet-15443	111	60	in	in	ADP
cet-15443	111	61	batch	batch	NOUN
cet-15443	111	62	systems	system	NOUN
cet-15443	111	63	.	.	PUNCT
cet-15443	112	1	european	european	ADJ
cet-15443	112	2	journal	journal	PROPN
cet-15443	112	3	of	of	ADP
cet-15443	112	4	biology	biology	NOUN
cet-15443	112	5	and	and	CCONJ
cet-15443	112	6	biotechnology	biotechnology	NOUN
cet-15443	112	7	,	,	PUNCT
cet-15443	112	8	3(1	3(1	NUM
cet-15443	112	9	)	)	PUNCT
cet-15443	112	10	,	,	PUNCT
cet-15443	112	11	1–10	1–10	NOUN
cet-15443	112	12	.	.	PUNCT
cet-15443	113	1	1158	1158	NUM
cet-15443	113	2	cet-vol117-b.pdf	cet-vol117-b.pdf	SYM
cet-15443	113	3	216traversari.pdf	216traversari.pdf	NUM
cet-15443	113	4	computational	computational	ADJ
cet-15443	113	5	analysis	analysis	NOUN
cet-15443	113	6	of	of	ADP
cet-15443	113	7	the	the	DET
cet-15443	113	8	effect	effect	NOUN
cet-15443	113	9	of	of	ADP
cet-15443	113	10	inhibitor	inhibitor	NOUN
cet-15443	113	11	proteins	protein	NOUN
cet-15443	113	12	p21	p21	NOUN
cet-15443	113	13	/	/	SYM
cet-15443	113	14	p27	p27	NOUN
cet-15443	113	15	on	on	ADP
cet-15443	113	16	cell	cell	NOUN
cet-15443	113	17	cycle	cycle	NOUN
cet-15443	113	18	under	under	ADP
cet-15443	113	19	microgravity	microgravity	NOUN
cet-15443	113	20	conditions	condition	NOUN