id	author	title	date	pages	extension	mime	words	sentence	flesch	summary	cache	txt
ctmj-146	Christian; Jihong	A new horizon for the steroidal alkaloid cyclovirobuxine D (huangyangning) and analogues: Anticancer activities and mechanism of action	2023	15	.pdf	application/pdf	7456	449	50	The ability of an acetonic B. sempervirens extract to suppress the growth of cancer cells and to induce apoptosis and autophagy in cancer cells is particularly noteworthy.33 While alkaloids and cyclovirobuxines are present in these extracts, they are far from the only natural compounds they contain. Buxmicrophylline B and N-acetyldihydrocyclomicrophylline F, both derived from B. microphylla, have shown cytotoxic effects on cancer cells, such as HL60 leukemia cells and human tumor HepG2 cells (with sub-micromolar activity against both types of cells).5 Not all Buxus alkaloids are cytotoxic; nevertheless, those that are either mildly or Additional beneficial characteristics may be shown by non-cytotoxic chemicals.	cache/ctmj-146.pdf	txt/ctmj-146.txt