id	author	title	date	pages	extension	mime	words	sentence	flesch	summary	cache	txt
ctmj-188	Rajesh Kumar; Ravi Prasad	Qingjie Fuzheng Granule and 5-fluorouracil Inhibit Colorectal Cancer Growth in a Synergistic Manner via the Phosphatidylinositol 3-Kinase/Protein Kinase B Pathway	2025	14	.pdf	application/pdf	7031	412	56	QFG: Qingjie Fuzheng Granule, 5‑FU: 5‑Fluorouracil EMT is a process in which epithelial cell phenotype transformed to mesenchymal cell phenotype under specific physiological or pathological conditions, which promotes the loss of intercellular adhesions, increases the metastatic capacity of cancer cells, inhibits apoptosis, and is an important factor affecting tumor recurrence and metastasis.[25-28] Cell-triggered EMT, which results in loss of epithelial cell integrity, and transcriptional repression of genes encoding epithelial cell-specific proteins such as E-Cadherin by transcription factors, contribute to the degradation of adherens junctions, and their adherens junctions are replaced by proteins capable of greater junctional flexibility (e.g., N‑Cadherin), leading to cell separation and enhanced cell motility.[29-34] Epithelial genes a c b d e f g h 53 CTMJ | traditionalmedicinejournals.com Chinese Traditional Medicine Journal | 2025 The growth and chemoresistance of colorectal cancer cells are regulated by the phosphatidylinositol-3-kinase/protein kinase B (PI3K/AKT) signaling system.	cache/ctmj-188.pdf	txt/ctmj-188.txt