id	sid	tid	token	lemma	pos
ctmj-146	1	1	a	a	DET
ctmj-146	1	2	new	new	ADJ
ctmj-146	1	3	horizon	horizon	NOUN
ctmj-146	1	4	for	for	ADP
ctmj-146	1	5	the	the	DET
ctmj-146	1	6	steroidal	steroidal	NOUN
ctmj-146	1	7	alkaloid	alkaloid	PROPN
ctmj-146	1	8	cyclovirobuxine	cyclovirobuxine	PROPN
ctmj-146	1	9	d	d	PROPN
ctmj-146	1	10	(	(	PUNCT
ctmj-146	1	11	huangyangning	huangyangning	NOUN
ctmj-146	1	12	)	)	PUNCT
ctmj-146	1	13	and	and	CCONJ
ctmj-146	1	14	analogues	analogue	NOUN
ctmj-146	1	15	:	:	PUNCT
ctmj-146	1	16	anticancer	anticancer	NOUN
ctmj-146	1	17	activities	activity	NOUN
ctmj-146	1	18	and	and	CCONJ
ctmj-146	1	19	mechanism	mechanism	NOUN
ctmj-146	1	20	of	of	ADP
ctmj-146	1	21	action	action	NOUN
ctmj-146	1	22	ctmj	ctmj	NOUN
ctmj-146	1	23	|	|	ADV
ctmj-146	1	24	traditionalmedicinejournals.com	traditionalmedicinejournals.com	X
ctmj-146	1	25	chinese	chinese	ADJ
ctmj-146	1	26	traditional	traditional	ADJ
ctmj-146	1	27	medicine	medicine	NOUN
ctmj-146	1	28	journal	journal	NOUN
ctmj-146	1	29	|	|	ADV
ctmj-146	1	30	2023	2023	NUM
ctmj-146	1	31	|	|	ADV
ctmj-146	1	32	vol	vol	NOUN
ctmj-146	1	33	6	6	NUM
ctmj-146	1	34	|	|	NOUN
ctmj-146	1	35	issue	issue	VERB
ctmj-146	1	36	3	3	NUM
ctmj-146	1	37	issn	issn	X
ctmj-146	1	38	:	:	PUNCT
ctmj-146	1	39	2693	2693	NUM
ctmj-146	1	40	6356	6356	NUM
ctmj-146	1	41	2023	2023	NUM
ctmj-146	1	42	|	|	ADV
ctmj-146	1	43	vol	vol	NOUN
ctmj-146	1	44	6	6	NUM
ctmj-146	1	45	|	|	NOUN
ctmj-146	1	46	issue	issue	VERB
ctmj-146	1	47	6	6	NUM
ctmj-146	1	48	a	a	DET
ctmj-146	1	49	new	new	ADJ
ctmj-146	1	50	horizon	horizon	NOUN
ctmj-146	1	51	for	for	ADP
ctmj-146	1	52	the	the	DET
ctmj-146	1	53	steroidal	steroidal	NOUN
ctmj-146	1	54	alkaloid	alkaloid	PROPN
ctmj-146	1	55	cyclovirobuxine	cyclovirobuxine	PROPN
ctmj-146	1	56	d	d	PROPN
ctmj-146	1	57	(	(	PUNCT
ctmj-146	1	58	huangyangning	huangyangning	NOUN
ctmj-146	1	59	)	)	PUNCT
ctmj-146	1	60	and	and	CCONJ
ctmj-146	1	61	analogues	analogue	NOUN
ctmj-146	1	62	:	:	PUNCT
ctmj-146	1	63	anticancer	anticancer	NOUN
ctmj-146	1	64	activities	activity	NOUN
ctmj-146	1	65	and	and	CCONJ
ctmj-146	1	66	mechanism	mechanism	NOUN
ctmj-146	1	67	of	of	ADP
ctmj-146	1	68	action	action	NOUN
ctmj-146	1	69	christian	christian	PROPN
ctmj-146	1	70	a	a	X
ctmj-146	1	71	,	,	PUNCT
ctmj-146	1	72	*	*	PROPN
ctmj-146	1	73	,	,	PUNCT
ctmj-146	1	74	jihong	jihong	PROPN
ctmj-146	1	75	b	b	PROPN
ctmj-146	1	76	a	a	DET
ctmj-146	1	77	oncowitan	oncowitan	PROPN
ctmj-146	1	78	,	,	PUNCT
ctmj-146	1	79	lille	lille	X
ctmj-146	1	80	(	(	PUNCT
ctmj-146	1	81	wasquehal	wasquehal	NOUN
ctmj-146	1	82	)	)	PUNCT
ctmj-146	1	83	,	,	PUNCT
ctmj-146	1	84	59290	59290	NUM
ctmj-146	1	85	,	,	PUNCT
ctmj-146	1	86	france	france	PROPN
ctmj-146	1	87	b	b	PROPN
ctmj-146	1	88	medical	medical	ADJ
ctmj-146	1	89	school	school	NOUN
ctmj-146	1	90	,	,	PUNCT
ctmj-146	1	91	kunming	kunming	PROPN
ctmj-146	1	92	university	university	PROPN
ctmj-146	1	93	of	of	ADP
ctmj-146	1	94	science	science	NOUN
ctmj-146	1	95	and	and	CCONJ
ctmj-146	1	96	technology	technology	NOUN
ctmj-146	1	97	,	,	PUNCT
ctmj-146	1	98	kunming	kunming	NOUN
ctmj-146	1	99	,	,	PUNCT
ctmj-146	1	100	650500	650500	NUM
ctmj-146	1	101	,	,	PUNCT
ctmj-146	1	102	china	china	PROPN
ctmj-146	1	103	introduction	introduction	NOUN
ctmj-146	1	104	an	an	DET
ctmj-146	1	105	evergreen	evergreen	NOUN
ctmj-146	1	106	shrub	shrub	NOUN
ctmj-146	1	107	endemic	endemic	ADJ
ctmj-146	1	108	to	to	ADP
ctmj-146	1	109	southern	southern	ADJ
ctmj-146	1	110	china	china	PROPN
ctmj-146	1	111	,	,	PUNCT
ctmj-146	1	112	buxus	buxus	NOUN
ctmj-146	1	113	microphylla	microphylla	PROPN
ctmj-146	1	114	var	var	PROPN
ctmj-146	1	115	.	.	PUNCT
ctmj-146	2	1	sinica	sinica	PROPN
ctmj-146	2	2	(	(	PUNCT
ctmj-146	2	3	chinese	chinese	ADJ
ctmj-146	2	4	boxwood	boxwood	NOUN
ctmj-146	2	5	,	,	PUNCT
ctmj-146	2	6	buxaceae	buxaceae	ADJ
ctmj-146	2	7	,	,	PUNCT
ctmj-146	2	8	小収黄杨	小収黄杨	PROPN
ctmj-146	2	9	)	)	PUNCT
ctmj-146	2	10	is	be	AUX
ctmj-146	2	11	beneficial	beneficial	ADJ
ctmj-146	2	12	for	for	ADP
ctmj-146	2	13	absorbing	absorb	VERB
ctmj-146	2	14	and	and	CCONJ
ctmj-146	2	15	containing	contain	VERB
ctmj-146	2	16	air	air	NOUN
ctmj-146	2	17	pollutants	pollutant	NOUN
ctmj-146	2	18	,	,	PUNCT
ctmj-146	2	19	such	such	ADJ
ctmj-146	2	20	as	as	ADP
ctmj-146	2	21	tiny	tiny	ADJ
ctmj-146	2	22	particulate	particulate	NOUN
ctmj-146	2	23	matter	matter	NOUN
ctmj-146	2	24	pm2.5.1	pm2.5.1	PROPN
ctmj-146	2	25	the	the	PRON
ctmj-146	2	26	aside	aside	ADV
ctmj-146	2	27	from	from	ADP
ctmj-146	2	28	being	be	AUX
ctmj-146	2	29	a	a	DET
ctmj-146	2	30	popular	popular	ADJ
ctmj-146	2	31	decorative	decorative	ADJ
ctmj-146	2	32	tree	tree	NOUN
ctmj-146	2	33	,	,	PUNCT
ctmj-146	2	34	it	it	PRON
ctmj-146	2	35	has	have	VERB
ctmj-146	2	36	a	a	DET
ctmj-146	2	37	long	long	ADJ
ctmj-146	2	38	history	history	NOUN
ctmj-146	2	39	of	of	ADP
ctmj-146	2	40	usage	usage	NOUN
ctmj-146	2	41	in	in	ADP
ctmj-146	2	42	traditional	traditional	ADJ
ctmj-146	2	43	chinese	chinese	ADJ
ctmj-146	2	44	medicine	medicine	NOUN
ctmj-146	2	45	(	(	PUNCT
ctmj-146	2	46	huang	huang	PROPN
ctmj-146	2	47	yang	yang	PROPN
ctmj-146	2	48	mu	mu	PROPN
ctmj-146	2	49	ye	ye	PROPN
ctmj-146	2	50	,	,	PUNCT
ctmj-146	2	51	xiaoyehuangyang	xiaoyehuangyang	PROPN
ctmj-146	2	52	)	)	PUNCT
ctmj-146	2	53	for	for	ADP
ctmj-146	2	54	the	the	DET
ctmj-146	2	55	treatment	treatment	NOUN
ctmj-146	2	56	of	of	ADP
ctmj-146	2	57	cardiovascular	cardiovascular	ADJ
ctmj-146	2	58	diseases	disease	NOUN
ctmj-146	2	59	in	in	ADP
ctmj-146	2	60	china.2	china.2	PROPN
ctmj-146	2	61	the	the	DET
ctmj-146	2	62	buxmicrophyllines	buxmicrophylline	NOUN
ctmj-146	2	63	and	and	CCONJ
ctmj-146	2	64	other	other	ADJ
ctmj-146	2	65	cycloartane	cycloartane	NOUN
ctmj-146	2	66	type	type	NOUN
ctmj-146	2	67	alkaloids	alkaloid	NOUN
ctmj-146	2	68	are	be	AUX
ctmj-146	2	69	present	present	ADJ
ctmj-146	2	70	in	in	ADP
ctmj-146	2	71	b.	b.	PROPN
ctmj-146	2	72	microphylla	microphylla	NOUN
ctmj-146	2	73	extracts	extract	NOUN
ctmj-146	2	74	,	,	PUNCT
ctmj-146	2	75	among	among	ADP
ctmj-146	2	76	other	other	ADJ
ctmj-146	2	77	triterpenoid	triterpenoid	VERB
ctmj-146	2	78	alkaloids.three	alkaloids.three	NUM
ctmj-146	2	79	to	to	PART
ctmj-146	2	80	five	five	NUM
ctmj-146	2	81	different	different	ADJ
ctmj-146	2	82	cancer	cancer	NOUN
ctmj-146	2	83	cell	cell	NOUN
ctmj-146	2	84	lines	line	NOUN
ctmj-146	2	85	have	have	AUX
ctmj-146	2	86	been	be	AUX
ctmj-146	2	87	shown	show	VERB
ctmj-146	2	88	to	to	PART
ctmj-146	2	89	be	be	AUX
ctmj-146	2	90	significantly	significantly	ADV
ctmj-146	2	91	cytotoxic	cytotoxic	ADJ
ctmj-146	2	92	by	by	ADP
ctmj-146	2	93	buxmicrophylline	buxmicrophylline	PROPN
ctmj-146	2	94	b	b	PROPN
ctmj-146	2	95	and	and	CCONJ
ctmj-146	2	96	r.four	r.four	NOUN
ctmj-146	2	97	,	,	PUNCT
ctmj-146	2	98	six	six	NUM
ctmj-146	2	99	other	other	ADJ
ctmj-146	2	100	chemicals	chemical	NOUN
ctmj-146	2	101	have	have	AUX
ctmj-146	2	102	been	be	AUX
ctmj-146	2	103	extracted	extract	VERB
ctmj-146	2	104	from	from	ADP
ctmj-146	2	105	the	the	DET
ctmj-146	2	106	plant	plant	NOUN
ctmj-146	2	107	's	's	PART
ctmj-146	2	108	roots	root	NOUN
ctmj-146	2	109	and	and	CCONJ
ctmj-146	2	110	leaves.as	leaves.as	PRON
ctmj-146	2	111	well	well	INTJ
ctmj-146	2	112	as	as	ADP
ctmj-146	2	113	cyclomicrobuxinine	cyclomicrobuxinine	ADJ
ctmj-146	2	114	and	and	CCONJ
ctmj-146	2	115	buxbodine	buxbodine	PROPN
ctmj-146	2	116	b	b	PROPN
ctmj-146	2	117	found	find	VERB
ctmj-146	2	118	in	in	ADP
ctmj-146	2	119	plants	plant	NOUN
ctmj-146	2	120	.	.	PUNCT
ctmj-146	3	1	however	however	ADV
ctmj-146	3	2	,	,	PUNCT
ctmj-146	3	3	cyclovirobuxine	cyclovirobuxine	PROPN
ctmj-146	3	4	d	d	PROPN
ctmj-146	3	5	(	(	PUNCT
ctmj-146	3	6	cvb	cvb	PROPN
ctmj-146	3	7	-	-	PUNCT
ctmj-146	3	8	d	d	PROPN
ctmj-146	3	9	,	,	PUNCT
ctmj-146	3	10	fig	fig	NOUN
ctmj-146	3	11	.	.	PUNCT
ctmj-146	4	1	1	1	NUM
ctmj-146	4	2	)	)	PUNCT
ctmj-146	4	3	,	,	PUNCT
ctmj-146	4	4	the	the	DET
ctmj-146	4	5	principal	principal	NOUN
ctmj-146	4	6	alkaloid	alkaloid	NOUN
ctmj-146	4	7	derived	derive	VERB
ctmj-146	4	8	from	from	ADP
ctmj-146	4	9	b.	b.	PROPN
ctmj-146	4	10	microphylla	microphylla	PROPN
ctmj-146	4	11	,	,	PUNCT
ctmj-146	4	12	has	have	AUX
ctmj-146	4	13	been	be	AUX
ctmj-146	4	14	in	in	ADP
ctmj-146	4	15	use	use	NOUN
ctmj-146	4	16	for	for	ADP
ctmj-146	4	17	over	over	ADP
ctmj-146	4	18	30	30	NUM
ctmj-146	4	19	years	year	NOUN
ctmj-146	4	20	in	in	ADP
ctmj-146	4	21	abstract	abstract	ADJ
ctmj-146	4	22	—	—	PUNCT
ctmj-146	4	23	for	for	ADP
ctmj-146	4	24	a	a	DET
ctmj-146	4	25	long	long	ADJ
ctmj-146	4	26	time	time	NOUN
ctmj-146	4	27	,	,	PUNCT
ctmj-146	4	28	huangyangning	huangyangne	VERB
ctmj-146	4	29	was	be	AUX
ctmj-146	4	30	a	a	DET
ctmj-146	4	31	standard	standard	ADJ
ctmj-146	4	32	therapy	therapy	NOUN
ctmj-146	4	33	for	for	ADP
ctmj-146	4	34	cardiovascular	cardiovascular	ADJ
ctmj-146	4	35	and	and	CCONJ
ctmj-146	4	36	cerebrovascular	cerebrovascular	ADJ
ctmj-146	4	37	illnesses	illness	NOUN
ctmj-146	4	38	in	in	ADP
ctmj-146	4	39	china	china	PROPN
ctmj-146	4	40	.	.	PUNCT
ctmj-146	5	1	its	its	PRON
ctmj-146	5	2	active	active	ADJ
ctmj-146	5	3	ingredient	ingredient	NOUN
ctmj-146	5	4	is	be	AUX
ctmj-146	5	5	the	the	DET
ctmj-146	5	6	steroidal	steroidal	NOUN
ctmj-146	5	7	alkaloid	alkaloid	NOUN
ctmj-146	5	8	cyclovirobuxine	cyclovirobuxine	PROPN
ctmj-146	5	9	d	d	PROPN
ctmj-146	5	10	(	(	PUNCT
ctmj-146	5	11	cvb	cvb	PROPN
ctmj-146	5	12	-	-	PROPN
ctmj-146	5	13	d	d	NOUN
ctmj-146	5	14	)	)	PUNCT
ctmj-146	5	15	.	.	PUNCT
ctmj-146	6	1	it	it	PRON
ctmj-146	6	2	is	be	AUX
ctmj-146	6	3	on	on	ADP
ctmj-146	6	4	the	the	DET
ctmj-146	6	5	chinese	chinese	ADJ
ctmj-146	6	6	pharmacopeia	pharmacopeia	PROPN
ctmj-146	6	7	list	list	NOUN
ctmj-146	6	8	.	.	PUNCT
ctmj-146	7	1	this	this	DET
ctmj-146	7	2	little	little	ADV
ctmj-146	7	3	-	-	PUNCT
ctmj-146	7	4	known	know	VERB
ctmj-146	7	5	alkaloid	alkaloid	NOUN
ctmj-146	7	6	has	have	AUX
ctmj-146	7	7	recently	recently	ADV
ctmj-146	7	8	come	come	VERB
ctmj-146	7	9	to	to	ADP
ctmj-146	7	10	light	light	NOUN
ctmj-146	7	11	as	as	ADP
ctmj-146	7	12	having	have	VERB
ctmj-146	7	13	anticancer	anticancer	NOUN
ctmj-146	7	14	effects	effect	NOUN
ctmj-146	7	15	in	in	ADP
ctmj-146	7	16	both	both	CCONJ
ctmj-146	7	17	laboratory	laboratory	NOUN
ctmj-146	7	18	and	and	CCONJ
ctmj-146	7	19	animal	animal	NOUN
ctmj-146	7	20	models	model	NOUN
ctmj-146	7	21	.	.	PUNCT
ctmj-146	8	1	the	the	DET
ctmj-146	8	2	medicine	medicine	NOUN
ctmj-146	8	3	inhibits	inhibit	VERB
ctmj-146	8	4	phosphorylation	phosphorylation	NOUN
ctmj-146	8	5	of	of	ADP
ctmj-146	8	6	proteins	protein	NOUN
ctmj-146	8	7	such	such	ADJ
ctmj-146	8	8	as	as	ADP
ctmj-146	8	9	egfr	egfr	NOUN
ctmj-146	8	10	,	,	PUNCT
ctmj-146	8	11	erk	erk	PROPN
ctmj-146	8	12	,	,	PUNCT
ctmj-146	8	13	akt	akt	PROPN
ctmj-146	8	14	,	,	PUNCT
ctmj-146	8	15	and	and	CCONJ
ctmj-146	8	16	mtor	mtor	PROPN
ctmj-146	8	17	,	,	PUNCT
ctmj-146	8	18	among	among	ADP
ctmj-146	8	19	others	other	NOUN
ctmj-146	8	20	,	,	PUNCT
ctmj-146	8	21	by	by	ADP
ctmj-146	8	22	activating	activate	VERB
ctmj-146	8	23	several	several	ADJ
ctmj-146	8	24	signaling	signal	VERB
ctmj-146	8	25	pathways	pathway	NOUN
ctmj-146	8	26	.	.	PUNCT
ctmj-146	9	1	consequently	consequently	ADV
ctmj-146	9	2	,	,	PUNCT
ctmj-146	9	3	cvb	cvb	PROPN
ctmj-146	9	4	-	-	PUNCT
ctmj-146	9	5	d	d	PROPN
ctmj-146	9	6	has	have	VERB
ctmj-146	9	7	anti	anti	ADJ
ctmj-146	9	8	-	-	ADJ
ctmj-146	9	9	metastatic	metastatic	ADJ
ctmj-146	9	10	and	and	CCONJ
ctmj-146	9	11	anti	anti	ADJ
ctmj-146	9	12	-	-	ADJ
ctmj-146	9	13	proliferative	proliferative	ADJ
ctmj-146	9	14	effects	effect	NOUN
ctmj-146	9	15	.	.	PUNCT
ctmj-146	10	1	cvb	cvb	PROPN
ctmj-146	10	2	-	-	PUNCT
ctmj-146	10	3	d	d	PROPN
ctmj-146	10	4	and	and	CCONJ
ctmj-146	10	5	similar	similar	ADJ
ctmj-146	10	6	natural	natural	ADJ
ctmj-146	10	7	compounds	compound	NOUN
ctmj-146	10	8	derived	derive	VERB
ctmj-146	10	9	from	from	ADP
ctmj-146	10	10	buxus	buxus	NOUN
ctmj-146	10	11	species	specie	NOUN
ctmj-146	10	12	have	have	AUX
ctmj-146	10	13	been	be	AUX
ctmj-146	10	14	studied	study	VERB
ctmj-146	10	15	for	for	ADP
ctmj-146	10	16	their	their	PRON
ctmj-146	10	17	potential	potential	ADJ
ctmj-146	10	18	anticancer	anticancer	NOUN
ctmj-146	10	19	properties	property	NOUN
ctmj-146	10	20	in	in	ADP
ctmj-146	10	21	this	this	DET
ctmj-146	10	22	review	review	NOUN
ctmj-146	10	23	.	.	PUNCT
ctmj-146	11	1	current	current	ADJ
ctmj-146	11	2	knowledge	knowledge	NOUN
ctmj-146	11	3	on	on	ADP
ctmj-146	11	4	the	the	DET
ctmj-146	11	5	molecular	molecular	ADJ
ctmj-146	11	6	targets	target	NOUN
ctmj-146	11	7	of	of	ADP
ctmj-146	11	8	cvb	cvb	PROPN
ctmj-146	11	9	-	-	PUNCT
ctmj-146	11	10	d	d	PROPN
ctmj-146	11	11	is	be	AUX
ctmj-146	11	12	limited	limited	ADJ
ctmj-146	11	13	;	;	PUNCT
ctmj-146	11	14	nevertheless	nevertheless	ADV
ctmj-146	11	15	,	,	PUNCT
ctmj-146	11	16	theories	theory	NOUN
ctmj-146	11	17	have	have	AUX
ctmj-146	11	18	been	be	AUX
ctmj-146	11	19	developed	develop	VERB
ctmj-146	11	20	by	by	ADP
ctmj-146	11	21	examining	examine	VERB
ctmj-146	11	22	the	the	DET
ctmj-146	11	23	drug	drug	NOUN
ctmj-146	11	24	's	's	PART
ctmj-146	11	25	effects	effect	NOUN
ctmj-146	11	26	on	on	ADP
ctmj-146	11	27	signaling	signal	VERB
ctmj-146	11	28	pathways	pathway	NOUN
ctmj-146	11	29	and	and	CCONJ
ctmj-146	11	30	drawing	draw	VERB
ctmj-146	11	31	comparisons	comparison	NOUN
ctmj-146	11	32	to	to	ADP
ctmj-146	11	33	other	other	ADJ
ctmj-146	11	34	drugs	drug	NOUN
ctmj-146	11	35	.	.	PUNCT
ctmj-146	12	1	potential	potential	ADJ
ctmj-146	12	2	upstream	upstream	ADJ
ctmj-146	12	3	targets	target	NOUN
ctmj-146	12	4	of	of	ADP
ctmj-146	12	5	cvb	cvb	PROPN
ctmj-146	12	6	-	-	PUNCT
ctmj-146	12	7	d	d	PROPN
ctmj-146	12	8	include	include	VERB
ctmj-146	12	9	the	the	DET
ctmj-146	12	10	proteins	protein	NOUN
ctmj-146	12	11	egfr	egfr	NOUN
ctmj-146	12	12	and	and	CCONJ
ctmj-146	12	13	cthrc1	cthrc1	PROPN
ctmj-146	12	14	,	,	PUNCT
ctmj-146	12	15	which	which	PRON
ctmj-146	12	16	are	be	AUX
ctmj-146	12	17	involved	involve	VERB
ctmj-146	12	18	in	in	ADP
ctmj-146	12	19	its	its	PRON
ctmj-146	12	20	anti	anti	ADJ
ctmj-146	12	21	-	-	ADJ
ctmj-146	12	22	proliferative	proliferative	ADJ
ctmj-146	12	23	effect	effect	NOUN
ctmj-146	12	24	.	.	PUNCT
ctmj-146	13	1	as	as	ADP
ctmj-146	13	2	a	a	DET
ctmj-146	13	3	further	further	ADJ
ctmj-146	13	4	,	,	PUNCT
ctmj-146	13	5	more	more	ADV
ctmj-146	13	6	audacious	audacious	ADJ
ctmj-146	13	7	hypothesis	hypothesis	NOUN
ctmj-146	13	8	,	,	PUNCT
ctmj-146	13	9	the	the	DET
ctmj-146	13	10	metastasis	metastasis	NOUN
ctmj-146	13	11	-	-	PUNCT
ctmj-146	13	12	associated	associate	VERB
ctmj-146	13	13	protein	protein	NOUN
ctmj-146	13	14	s100a4	s100a4	ADV
ctmj-146	13	15	is	be	AUX
ctmj-146	13	16	proposed	propose	VERB
ctmj-146	13	17	as	as	ADP
ctmj-146	13	18	a	a	DET
ctmj-146	13	19	possible	possible	ADJ
ctmj-146	13	20	co	co	NOUN
ctmj-146	13	21	-	-	NOUN
ctmj-146	13	22	target	target	NOUN
ctmj-146	13	23	for	for	ADP
ctmj-146	13	24	cvb	cvb	PROPN
ctmj-146	13	25	-	-	PROPN
ctmj-146	13	26	d.	d.	PROPN
ctmj-146	13	27	with	with	ADP
ctmj-146	13	28	its	its	PRON
ctmj-146	13	29	well	well	ADV
ctmj-146	13	30	-	-	PUNCT
ctmj-146	13	31	established	establish	VERB
ctmj-146	13	32	anti	anti	ADJ
ctmj-146	13	33	-	-	ADJ
ctmj-146	13	34	cardiovascular	cardiovascular	ADJ
ctmj-146	13	35	effectiveness	effectiveness	NOUN
ctmj-146	13	36	and	and	CCONJ
ctmj-146	13	37	promising	promise	VERB
ctmj-146	13	38	safety	safety	NOUN
ctmj-146	13	39	profile	profile	NOUN
ctmj-146	13	40	,	,	PUNCT
ctmj-146	13	41	cvb	cvb	PROPN
ctmj-146	13	42	-	-	PUNCT
ctmj-146	13	43	d	d	PROPN
ctmj-146	13	44	has	have	VERB
ctmj-146	13	45	the	the	DET
ctmj-146	13	46	potential	potential	NOUN
ctmj-146	13	47	to	to	PART
ctmj-146	13	48	be	be	AUX
ctmj-146	13	49	the	the	DET
ctmj-146	13	50	subject	subject	NOUN
ctmj-146	13	51	of	of	ADP
ctmj-146	13	52	more	more	ADV
ctmj-146	13	53	mechanistic	mechanistic	ADJ
ctmj-146	13	54	investigations	investigation	NOUN
ctmj-146	13	55	into	into	ADP
ctmj-146	13	56	its	its	PRON
ctmj-146	13	57	anticancer	anticancer	NOUN
ctmj-146	13	58	effects	effect	NOUN
ctmj-146	13	59	.	.	PUNCT
ctmj-146	14	1	medicine	medicine	NOUN
ctmj-146	14	2	since	since	SCONJ
ctmj-146	14	3	its	its	PRON
ctmj-146	14	4	discovery	discovery	NOUN
ctmj-146	14	5	in	in	ADP
ctmj-146	14	6	1964,7	1964,7	NUM
ctmj-146	14	7	and	and	CCONJ
ctmj-146	14	8	thorough	thorough	ADJ
ctmj-146	14	9	characterization	characterization	NOUN
ctmj-146	14	10	in	in	ADP
ctmj-146	14	11	1979,8.10	1979,8.10	NUM
ctmj-146	14	12	cvb	cvb	PROPN
ctmj-146	14	13	-	-	PUNCT
ctmj-146	14	14	d	d	PROPN
ctmj-146	14	15	is	be	AUX
ctmj-146	14	16	a	a	DET
ctmj-146	14	17	pregnane	pregnane	ADJ
ctmj-146	14	18	-	-	PUNCT
ctmj-146	14	19	derived	derive	VERB
ctmj-146	14	20	steroidal	steroidal	NOUN
ctmj-146	14	21	alkaloid	alkaloid	NOUN
ctmj-146	14	22	that	that	PRON
ctmj-146	14	23	has	have	VERB
ctmj-146	14	24	a	a	DET
ctmj-146	14	25	low	low	ADJ
ctmj-146	14	26	water	water	NOUN
ctmj-146	14	27	solubility	solubility	NOUN
ctmj-146	14	28	but	but	CCONJ
ctmj-146	14	29	a	a	DET
ctmj-146	14	30	satisfactory	satisfactory	ADJ
ctmj-146	14	31	bioavailability	bioavailability	NOUN
ctmj-146	14	32	when	when	SCONJ
ctmj-146	14	33	made	make	VERB
ctmj-146	14	34	into	into	ADP
ctmj-146	14	35	disintegrating	disintegrate	VERB
ctmj-146	14	36	tablets.11	tablets.11	NOUN
ctmj-146	14	37	the	the	DET
ctmj-146	14	38	cfda	cfda	PROPN
ctmj-146	14	39	of	of	ADP
ctmj-146	14	40	china	china	PROPN
ctmj-146	14	41	authorized	authorize	VERB
ctmj-146	14	42	huangyangning	huangyangne	VERB
ctmj-146	14	43	dispersible	dispersible	ADJ
ctmj-146	14	44	tablets	tablet	NOUN
ctmj-146	14	45	(	(	PUNCT
ctmj-146	14	46	fig	fig	NOUN
ctmj-146	14	47	.	.	NOUN
ctmj-146	15	1	1	1	NUM
ctmj-146	15	2	)	)	PUNCT
ctmj-146	15	3	in	in	ADP
ctmj-146	15	4	2009	2009	NUM
ctmj-146	15	5	to	to	PART
ctmj-146	15	6	treat	treat	VERB
ctmj-146	15	7	various	various	ADJ
ctmj-146	15	8	cerebrovascular	cerebrovascular	ADJ
ctmj-146	15	9	and	and	CCONJ
ctmj-146	15	10	cardiovascular	cardiovascular	ADJ
ctmj-146	15	11	diseases	disease	NOUN
ctmj-146	15	12	,	,	PUNCT
ctmj-146	15	13	including	include	VERB
ctmj-146	15	14	coronary	coronary	ADJ
ctmj-146	15	15	heart	heart	NOUN
ctmj-146	15	16	disease	disease	NOUN
ctmj-146	15	17	,	,	PUNCT
ctmj-146	15	18	angina	angina	PROPN
ctmj-146	15	19	pectoris	pectoris	PROPN
ctmj-146	15	20	,	,	PUNCT
ctmj-146	15	21	arrhythmia	arrhythmia	NOUN
ctmj-146	15	22	,	,	PUNCT
ctmj-146	15	23	heart	heart	NOUN
ctmj-146	15	24	failure	failure	NOUN
ctmj-146	15	25	,	,	PUNCT
ctmj-146	15	26	hypertension	hypertension	NOUN
ctmj-146	15	27	,	,	PUNCT
ctmj-146	15	28	and	and	CCONJ
ctmj-146	15	29	cardiac	cardiac	ADJ
ctmj-146	15	30	neurosis	neurosis	NOUN
ctmj-146	15	31	.	.	PUNCT
ctmj-146	16	1	cvb	cvb	PROPN
ctmj-146	16	2	-	-	PUNCT
ctmj-146	16	3	d	d	PROPN
ctmj-146	16	4	is	be	AUX
ctmj-146	16	5	the	the	DET
ctmj-146	16	6	active	active	ADJ
ctmj-146	16	7	ingredient	ingredient	NOUN
ctmj-146	16	8	in	in	ADP
ctmj-146	16	9	these	these	DET
ctmj-146	16	10	tablets.12	tablets.12	NOUN
ctmj-146	16	11	the	the	DET
ctmj-146	16	12	2015	2015	NUM
ctmj-146	16	13	chinese	chinese	ADJ
ctmj-146	16	14	pharmacopoeia	pharmacopoeia	NOUN
ctmj-146	16	15	includes	include	VERB
ctmj-146	16	16	it	it	PRON
ctmj-146	16	17	.	.	PUNCT
ctmj-146	17	1	cvb	cvb	PROPN
ctmj-146	17	2	-	-	PUNCT
ctmj-146	17	3	d	d	NOUN
ctmj-146	17	4	modulates	modulate	NOUN
ctmj-146	17	5	blood	blood	NOUN
ctmj-146	17	6	pressure	pressure	NOUN
ctmj-146	17	7	by	by	ADP
ctmj-146	17	8	expanding	expand	VERB
ctmj-146	17	9	blood	blood	NOUN
ctmj-146	17	10	vessels	vessel	NOUN
ctmj-146	17	11	and	and	CCONJ
ctmj-146	17	12	increasing	increase	VERB
ctmj-146	17	13	coronary	coronary	ADJ
ctmj-146	17	14	flow	flow	NOUN
ctmj-146	17	15	.	.	PUNCT
ctmj-146	18	1	in	in	ADP
ctmj-146	18	2	addition	addition	NOUN
ctmj-146	18	3	to	to	ADP
ctmj-146	18	4	lowering	lower	VERB
ctmj-146	18	5	oxygen	oxygen	NOUN
ctmj-146	18	6	consumption	consumption	NOUN
ctmj-146	18	7	by	by	ADP
ctmj-146	18	8	the	the	DET
ctmj-146	18	9	heart	heart	NOUN
ctmj-146	18	10	,	,	PUNCT
ctmj-146	18	11	it	it	PRON
ctmj-146	18	12	has	have	VERB
ctmj-146	18	13	an	an	DET
ctmj-146	18	14	antiarrhythmic	antiarrhythmic	ADJ
ctmj-146	18	15	action	action	NOUN
ctmj-146	18	16	.	.	PUNCT
ctmj-146	19	1	this	this	DET
ctmj-146	19	2	medicine	medicine	NOUN
ctmj-146	19	3	has	have	VERB
ctmj-146	19	4	a	a	DET
ctmj-146	19	5	lengthy	lengthy	ADJ
ctmj-146	19	6	history	history	NOUN
ctmj-146	19	7	of	of	ADP
ctmj-146	19	8	usage	usage	NOUN
ctmj-146	19	9	in	in	ADP
ctmj-146	19	10	preventing	prevent	VERB
ctmj-146	19	11	acute	acute	ADJ
ctmj-146	19	12	cerebral	cerebral	ADJ
ctmj-146	19	13	ischemia	ischemia	NOUN
ctmj-146	19	14	and	and	CCONJ
ctmj-146	19	15	myocardial	myocardial	ADJ
ctmj-146	19	16	ischemia.multiple	ischemia.multiple	ADJ
ctmj-146	19	17	pharmacological	pharmacological	ADJ
ctmj-146	19	18	investigations	investigation	NOUN
ctmj-146	19	19	in	in	ADP
ctmj-146	19	20	animal	animal	NOUN
ctmj-146	19	21	models	model	NOUN
ctmj-146	19	22	(	(	PUNCT
ctmj-146	19	23	13–15	13–15	NUM
ctmj-146	19	24	)	)	PUNCT
ctmj-146	19	25	and	and	CCONJ
ctmj-146	19	26	clinical	clinical	ADJ
ctmj-146	19	27	trials	trial	NOUN
ctmj-146	19	28	have	have	AUX
ctmj-146	19	29	shown	show	VERB
ctmj-146	19	30	cvb	cvb	PROPN
ctmj-146	19	31	-	-	PUNCT
ctmj-146	19	32	d	d	PROPN
ctmj-146	19	33	's	's	PART
ctmj-146	19	34	therapeutic	therapeutic	ADJ
ctmj-146	19	35	impact	impact	NOUN
ctmj-146	19	36	on	on	ADP
ctmj-146	19	37	heart	heart	NOUN
ctmj-146	19	38	failure	failure	NOUN
ctmj-146	19	39	caused	cause	VERB
ctmj-146	19	40	by	by	ADP
ctmj-146	19	41	myocardial	myocardial	ADJ
ctmj-146	19	42	infarction.2	infarction.2	PROPN
ctmj-146	19	43	the	the	DET
ctmj-146	19	44	compound	compound	NOUN
ctmj-146	19	45	known	know	VERB
ctmj-146	19	46	as	as	ADP
ctmj-146	19	47	jlx001	jlx001	PROPN
ctmj-146	19	48	,	,	PUNCT
ctmj-146	19	49	which	which	PRON
ctmj-146	19	50	is	be	AUX
ctmj-146	19	51	the	the	DET
ctmj-146	19	52	cvb	cvb	PROPN
ctmj-146	19	53	-	-	PUNCT
ctmj-146	19	54	d	d	PROPN
ctmj-146	19	55	dihydrochloride	dihydrochloride	NOUN
ctmj-146	19	56	salt	salt	NOUN
ctmj-146	19	57	the	the	DET
ctmj-146	19	58	drug	drug	NOUN
ctmj-146	19	59	is	be	AUX
ctmj-146	19	60	now	now	ADV
ctmj-146	19	61	in	in	ADP
ctmj-146	19	62	development	development	NOUN
ctmj-146	19	63	by	by	ADP
ctmj-146	19	64	zhejiang	zhejiang	PROPN
ctmj-146	19	65	jingxin	jingxin	PROPN
ctmj-146	19	66	pharmaceutical	pharmaceutical	PROPN
ctmj-146	19	67	co.	co.	PROPN
ctmj-146	19	68	of	of	ADP
ctmj-146	19	69	shaoxing	shaoxing	PROPN
ctmj-146	19	70	,	,	PUNCT
ctmj-146	19	71	china	china	PROPN
ctmj-146	19	72	,	,	PUNCT
ctmj-146	19	73	with	with	ADP
ctmj-146	19	74	the	the	DET
ctmj-146	19	75	goal	goal	NOUN
ctmj-146	19	76	of	of	ADP
ctmj-146	19	77	treating	treat	VERB
ctmj-146	19	78	ischemic	ischemic	ADJ
ctmj-146	19	79	stroke.16	stroke.16	NOUN
ctmj-146	19	80	just	just	ADV
ctmj-146	19	81	recently	recently	ADV
ctmj-146	19	82	,	,	PUNCT
ctmj-146	19	83	research	research	NOUN
ctmj-146	19	84	has	have	AUX
ctmj-146	19	85	shown	show	VERB
ctmj-146	19	86	that	that	SCONJ
ctmj-146	19	87	jlx001	jlx001	PROPN
ctmj-146	19	88	may	may	AUX
ctmj-146	19	89	effectively	effectively	ADV
ctmj-146	19	90	reduce	reduce	VERB
ctmj-146	19	91	cerebral	cerebral	ADJ
ctmj-146	19	92	ischemia	ischemia	NOUN
ctmj-146	19	93	damage	damage	NOUN
ctmj-146	19	94	by	by	ADP
ctmj-146	19	95	blocking	block	VERB
ctmj-146	19	96	platelet	platelet	NOUN
ctmj-146	19	97	activation	activation	NOUN
ctmj-146	19	98	and	and	CCONJ
ctmj-146	19	99	thrombus	thrombus	NOUN
ctmj-146	19	100	formation.17	formation.17	PROPN
ctmj-146	19	101	as	as	ADP
ctmj-146	19	102	its	its	PRON
ctmj-146	19	103	principal	principal	ADJ
ctmj-146	19	104	route	route	NOUN
ctmj-146	19	105	of	of	ADP
ctmj-146	19	106	action	action	NOUN
ctmj-146	19	107	,	,	PUNCT
ctmj-146	19	108	jlx001	jlx001	PROPN
ctmj-146	19	109	inhibited	inhibit	VERB
ctmj-146	19	110	oxidative	oxidative	ADJ
ctmj-146	19	111	stress	stress	NOUN
ctmj-146	19	112	and	and	CCONJ
ctmj-146	19	113	inflammation	inflammation	NOUN
ctmj-146	19	114	in	in	ADP
ctmj-146	19	115	animal	animal	NOUN
ctmj-146	19	116	models	model	NOUN
ctmj-146	19	117	via	via	ADP
ctmj-146	19	118	modulating	modulate	VERB
ctmj-146	19	119	the	the	DET
ctmj-146	19	120	tlr2/4	tlr2/4	NOUN
ctmj-146	19	121	-	-	PUNCT
ctmj-146	19	122	nf	nf	INTJ
ctmj-146	19	123	-	-	PUNCT
ctmj-146	19	124	kb	kb	NOUN
ctmj-146	19	125	and	and	CCONJ
ctmj-146	19	126	ampkulk1	ampkulk1	NOUN
ctmj-146	19	127	signaling	signal	VERB
ctmj-146	19	128	pathways	pathway	NOUN
ctmj-146	19	129	.	.	PUNCT
ctmj-146	20	1	the	the	DET
ctmj-146	20	2	brain	brain	NOUN
ctmj-146	20	3	is	be	AUX
ctmj-146	20	4	protected	protect	VERB
ctmj-146	20	5	against	against	ADP
ctmj-146	20	6	ischemia	ischemia	NOUN
ctmj-146	20	7	damage	damage	NOUN
ctmj-146	20	8	by	by	ADP
ctmj-146	20	9	this	this	DET
ctmj-146	20	10	investigational	investigational	ADJ
ctmj-146	20	11	medication.18	medication.18	NOUN
ctmj-146	20	12	,	,	PUNCT
ctmj-146	20	13	19	19	NUM
ctmj-146	20	14	when	when	SCONJ
ctmj-146	20	15	it	it	PRON
ctmj-146	20	16	comes	come	VERB
ctmj-146	20	17	to	to	ADP
ctmj-146	20	18	human	human	ADJ
ctmj-146	20	19	clinical	clinical	ADJ
ctmj-146	20	20	trials	trial	NOUN
ctmj-146	20	21	,	,	PUNCT
ctmj-146	20	22	jlx001	jlx001	PROPN
ctmj-146	20	23	is	be	AUX
ctmj-146	20	24	an	an	DET
ctmj-146	20	25	intriguing	intriguing	ADJ
ctmj-146	20	26	candidate	candidate	NOUN
ctmj-146	20	27	.	.	PUNCT
ctmj-146	21	1	cancer	cancer	NOUN
ctmj-146	21	2	therapy	therapy	NOUN
ctmj-146	21	3	is	be	AUX
ctmj-146	21	4	one	one	NUM
ctmj-146	21	5	of	of	ADP
ctmj-146	21	6	many	many	ADJ
ctmj-146	21	7	new	new	ADJ
ctmj-146	21	8	possible	possible	ADJ
ctmj-146	21	9	therapeutic	therapeutic	ADJ
ctmj-146	21	10	indications	indication	NOUN
ctmj-146	21	11	for	for	ADP
ctmj-146	21	12	cvb	cvb	PROPN
ctmj-146	21	13	-	-	PROPN
ctmj-146	21	14	d	d	PROPN
ctmj-146	21	15	that	that	PRON
ctmj-146	21	16	has	have	AUX
ctmj-146	21	17	emerged	emerge	VERB
ctmj-146	21	18	in	in	ADP
ctmj-146	21	19	recent	recent	ADJ
ctmj-146	21	20	years	year	NOUN
ctmj-146	21	21	.	.	PUNCT
ctmj-146	22	1	this	this	DET
ctmj-146	22	2	article	article	NOUN
ctmj-146	22	3	provides	provide	VERB
ctmj-146	22	4	a	a	DET
ctmj-146	22	5	summary	summary	NOUN
ctmj-146	22	6	of	of	ADP
ctmj-146	22	7	cvb	cvb	NOUN
ctmj-146	22	8	-	-	NOUN
ctmj-146	22	9	anticancer	anticancer	NOUN
ctmj-146	22	10	d	d	PROPN
ctmj-146	22	11	's	's	PART
ctmj-146	22	12	characteristics	characteristic	NOUN
ctmj-146	22	13	and	and	CCONJ
ctmj-146	22	14	the	the	DET
ctmj-146	22	15	current	current	ADJ
ctmj-146	22	16	understanding	understanding	NOUN
ctmj-146	22	17	of	of	ADP
ctmj-146	22	18	its	its	PRON
ctmj-146	22	19	action	action	NOUN
ctmj-146	22	20	mechanism	mechanism	NOUN
ctmj-146	22	21	.	.	PUNCT
ctmj-146	23	1	anticancer	anticancer	NOUN
ctmj-146	23	2	activity	activity	NOUN
ctmj-146	23	3	of	of	ADP
ctmj-146	23	4	cyclovirobuxine	cyclovirobuxine	PROPN
ctmj-146	23	5	d	d	PROPN
ctmj-146	23	6	human	human	ADJ
ctmj-146	23	7	breast	breast	NOUN
ctmj-146	23	8	cancer	cancer	NOUN
ctmj-146	23	9	cells	cell	NOUN
ctmj-146	23	10	were	be	AUX
ctmj-146	23	11	used	use	VERB
ctmj-146	23	12	in	in	ADP
ctmj-146	23	13	an	an	DET
ctmj-146	23	14	in	in	ADP
ctmj-146	23	15	vitro	vitro	X
ctmj-146	23	16	investigation	investigation	NOUN
ctmj-146	23	17	to	to	PART
ctmj-146	23	18	establish	establish	VERB
ctmj-146	23	19	that	that	SCONJ
ctmj-146	23	20	cvb	cvb	PROPN
ctmj-146	23	21	-	-	PROPN
ctmj-146	23	22	d	d	PROPN
ctmj-146	23	23	had	have	VERB
ctmj-146	23	24	an	an	DET
ctmj-146	23	25	anticancer	anticancer	NOUN
ctmj-146	23	26	impact	impact	NOUN
ctmj-146	23	27	.	.	PUNCT
ctmj-146	24	1	at	at	ADP
ctmj-146	24	2	an	an	DET
ctmj-146	24	3	ic50	ic50	PROPN
ctmj-146	24	4	of	of	ADP
ctmj-146	24	5	10	10	NUM
ctmj-146	24	6	mm	mm	NOUN
ctmj-146	24	7	,	,	PUNCT
ctmj-146	24	8	the	the	DET
ctmj-146	24	9	drug	drug	NOUN
ctmj-146	24	10	was	be	AUX
ctmj-146	24	11	discovered	discover	VERB
ctmj-146	24	12	to	to	PART
ctmj-146	24	13	decrease	decrease	VERB
ctmj-146	24	14	mcf7	mcf7	PROPN
ctmj-146	24	15	cell	cell	NOUN
ctmj-146	24	16	viability	viability	NOUN
ctmj-146	24	17	.	.	PUNCT
ctmj-146	25	1	after	after	ADP
ctmj-146	25	2	24	24	NUM
ctmj-146	25	3	hours	hour	NOUN
ctmj-146	25	4	of	of	ADP
ctmj-146	25	5	treatment	treatment	NOUN
ctmj-146	25	6	,	,	PUNCT
ctmj-146	25	7	it	it	PRON
ctmj-146	25	8	was	be	AUX
ctmj-146	25	9	discovered	discover	VERB
ctmj-146	25	10	to	to	PART
ctmj-146	25	11	induce	induce	VERB
ctmj-146	25	12	autophagy	autophagy	NOUN
ctmj-146	25	13	,	,	PUNCT
ctmj-146	25	14	which	which	PRON
ctmj-146	25	15	is	be	AUX
ctmj-146	25	16	marked	mark	VERB
ctmj-146	25	17	by	by	ADP
ctmj-146	25	18	the	the	DET
ctmj-146	25	19	appearance	appearance	NOUN
ctmj-146	25	20	of	of	ADP
ctmj-146	25	21	autophagosomes	autophagosome	NOUN
ctmj-146	25	22	/	/	SYM
ctmj-146	25	23	autolysosomes	autolysosome	NOUN
ctmj-146	25	24	and	and	CCONJ
ctmj-146	25	25	the	the	DET
ctmj-146	25	26	up	up	NOUN
ctmj-146	25	27	-	-	PUNCT
ctmj-146	25	28	regulation	regulation	NOUN
ctmj-146	25	29	of	of	ADP
ctmj-146	25	30	autophagy	autophagy	ADJ
ctmj-146	25	31	markers	marker	NOUN
ctmj-146	25	32	like	like	ADP
ctmj-146	25	33	microtubule	microtubule	NOUN
ctmj-146	25	34	-	-	PUNCT
ctmj-146	25	35	associated	associate	VERB
ctmj-146	25	36	protein	protein	NOUN
ctmj-146	25	37	lc3	lc3	NOUN
ctmj-146	25	38	-	-	NOUN
ctmj-146	25	39	ii	ii	NOUN
ctmj-146	25	40	and	and	CCONJ
ctmj-146	25	41	autophagy	autophagy	ADJ
ctmj-146	25	42	protein	protein	NOUN
ctmj-146	25	43	atg5.20	atg5.20	PROPN
ctmj-146	25	44	because	because	SCONJ
ctmj-146	25	45	cvb	cvb	PROPN
ctmj-146	25	46	-	-	PROPN
ctmj-146	25	47	d	d	PROPN
ctmj-146	25	48	at	at	ADP
ctmj-146	25	49	low	low	ADJ
ctmj-146	25	50	concentrations	concentration	NOUN
ctmj-146	25	51	(	(	PUNCT
ctmj-146	25	52	1e10	1e10	NUM
ctmj-146	25	53	mm	mm	NOUN
ctmj-146	25	54	)	)	PUNCT
ctmj-146	25	55	reduced	reduce	VERB
ctmj-146	25	56	akt	akt	PROPN
ctmj-146	25	57	phosphorylation	phosphorylation	NOUN
ctmj-146	25	58	and	and	CCONJ
ctmj-146	25	59	suppressed	suppress	VERB
ctmj-146	25	60	mtor	mtor	NOUN
ctmj-146	25	61	phosphorylation	phosphorylation	NOUN
ctmj-146	25	62	without	without	ADP
ctmj-146	25	63	altering	alter	VERB
ctmj-146	25	64	their	their	PRON
ctmj-146	25	65	intracellular	intracellular	ADJ
ctmj-146	25	66	expression	expression	NOUN
ctmj-146	25	67	levels	level	NOUN
ctmj-146	25	68	,	,	PUNCT
ctmj-146	25	69	it	it	PRON
ctmj-146	25	70	was	be	AUX
ctmj-146	25	71	hypothesized	hypothesize	VERB
ctmj-146	25	72	that	that	SCONJ
ctmj-146	25	73	this	this	DET
ctmj-146	25	74	inhibition	inhibition	NOUN
ctmj-146	25	75	of	of	ADP
ctmj-146	25	76	the	the	DET
ctmj-146	25	77	akt	akt	PROPN
ctmj-146	25	78	/	/	SYM
ctmj-146	25	79	mtor	mtor	PROPN
ctmj-146	25	80	axis	axis	NOUN
ctmj-146	25	81	was	be	AUX
ctmj-146	25	82	responsible	responsible	ADJ
ctmj-146	25	83	for	for	ADP
ctmj-146	25	84	autophagic	autophagic	PROPN
ctmj-146	25	85	activation.20	activation.20	PROPN
ctmj-146	25	86	another	another	PRON
ctmj-146	25	87	in	in	ADP
ctmj-146	25	88	vitro	vitro	X
ctmj-146	25	89	investigation	investigation	NOUN
ctmj-146	25	90	using	use	VERB
ctmj-146	25	91	two	two	NUM
ctmj-146	25	92	gastric	gastric	ADJ
ctmj-146	25	93	cancer	cancer	NOUN
ctmj-146	25	94	cell	cell	NOUN
ctmj-146	25	95	lines	line	NOUN
ctmj-146	25	96	found	find	VERB
ctmj-146	25	97	that	that	SCONJ
ctmj-146	25	98	cvb	cvb	PROPN
ctmj-146	25	99	-	-	PUNCT
ctmj-146	25	100	d	d	PROPN
ctmj-146	25	101	doseand	doseand	NOUN
ctmj-146	25	102	time	time	NOUN
ctmj-146	25	103	-	-	PUNCT
ctmj-146	25	104	dependently	dependently	ADV
ctmj-146	25	105	decreased	decrease	VERB
ctmj-146	25	106	cell	cell	NOUN
ctmj-146	25	107	proliferation	proliferation	NOUN
ctmj-146	25	108	of	of	ADP
ctmj-146	25	109	mgc-803	mgc-803	NOUN
ctmj-146	25	110	and	and	CCONJ
ctmj-146	25	111	mkn2	mkn2	NOUN
ctmj-146	25	112	cells	cell	NOUN
ctmj-146	25	113	;	;	PUNCT
ctmj-146	25	114	nevertheless	nevertheless	ADV
ctmj-146	25	115	,	,	PUNCT
ctmj-146	25	116	rather	rather	ADV
ctmj-146	25	117	high	high	ADJ
ctmj-146	25	118	doses	dose	NOUN
ctmj-146	25	119	(	(	PUNCT
ctmj-146	25	120	about	about	ADV
ctmj-146	25	121	50–60	50–60	NUM
ctmj-146	25	122	mm	mm	NOUN
ctmj-146	25	123	at	at	ADP
ctmj-146	25	124	72	72	NUM
ctmj-146	25	125	h	h	NOUN
ctmj-146	25	126	)	)	PUNCT
ctmj-146	25	127	were	be	AUX
ctmj-146	25	128	necessary	necessary	ADJ
ctmj-146	25	129	to	to	PART
ctmj-146	25	130	achieve	achieve	VERB
ctmj-146	25	131	a	a	DET
ctmj-146	25	132	50	50	NUM
ctmj-146	25	133	%	%	NOUN
ctmj-146	25	134	reduction	reduction	NOUN
ctmj-146	25	135	in	in	ADP
ctmj-146	25	136	cell	cell	NOUN
ctmj-146	25	137	growth	growth	NOUN
ctmj-146	25	138	.	.	PUNCT
ctmj-146	26	1	concentrations	concentration	NOUN
ctmj-146	26	2	lower	low	ADJ
ctmj-146	26	3	than	than	ADP
ctmj-146	26	4	10	10	NUM
ctmj-146	26	5	mm	mm	NOUN
ctmj-146	26	6	were	be	AUX
ctmj-146	26	7	more	more	ADV
ctmj-146	26	8	effective	effective	ADJ
ctmj-146	26	9	in	in	ADP
ctmj-146	26	10	inhibiting	inhibit	VERB
ctmj-146	26	11	colony	colony	NOUN
ctmj-146	26	12	development	development	NOUN
ctmj-146	26	13	.	.	PUNCT
ctmj-146	27	1	at	at	ADP
ctmj-146	27	2	very	very	ADV
ctmj-146	27	3	high	high	ADJ
ctmj-146	27	4	doses	dose	NOUN
ctmj-146	27	5	(	(	PUNCT
ctmj-146	27	6	i.e.	i.e.	X
ctmj-146	27	7	,	,	PUNCT
ctmj-146	27	8	30–120	30–120	NUM
ctmj-146	27	9	mm	mm	NOUN
ctmj-146	27	10	)	)	PUNCT
ctmj-146	27	11	,	,	PUNCT
ctmj-146	27	12	the	the	DET
ctmj-146	27	13	effect	effect	NOUN
ctmj-146	27	14	was	be	AUX
ctmj-146	27	15	followed	follow	VERB
ctmj-146	27	16	by	by	ADP
ctmj-146	27	17	a	a	DET
ctmj-146	27	18	disruption	disruption	NOUN
ctmj-146	27	19	of	of	ADP
ctmj-146	27	20	the	the	DET
ctmj-146	27	21	cell	cell	NOUN
ctmj-146	27	22	cycle	cycle	NOUN
ctmj-146	27	23	and	and	CCONJ
ctmj-146	27	24	the	the	DET
ctmj-146	27	25	activation	activation	NOUN
ctmj-146	27	26	of	of	ADP
ctmj-146	27	27	apoptosis	apoptosis	NOUN
ctmj-146	27	28	as	as	SCONJ
ctmj-146	27	29	shown	show	VERB
ctmj-146	27	30	by	by	ADP
ctmj-146	27	31	mitochondrial	mitochondrial	ADJ
ctmj-146	27	32	damages	damage	NOUN
ctmj-146	27	33	,	,	PUNCT
ctmj-146	27	34	caspase-3	caspase-3	NUM
ctmj-146	27	35	cleavage	cleavage	NOUN
ctmj-146	27	36	,	,	PUNCT
ctmj-146	27	37	bcl-2	bcl-2	VERB
ctmj-146	27	38	down	down	ADP
ctmj-146	27	39	-	-	PUNCT
ctmj-146	27	40	regulation	regulation	NOUN
ctmj-146	27	41	,	,	PUNCT
ctmj-146	27	42	and	and	CCONJ
ctmj-146	27	43	bax	bax	PROPN
ctmj-146	27	44	up	up	ADP
ctmj-146	27	45	-	-	PUNCT
ctmj-146	27	46	regulation.21	regulation.21	NOUN
ctmj-146	27	47	in	in	ADP
ctmj-146	27	48	their	their	PRON
ctmj-146	27	49	study	study	NOUN
ctmj-146	27	50	,	,	PUNCT
ctmj-146	27	51	the	the	DET
ctmj-146	27	52	scientists	scientist	NOUN
ctmj-146	27	53	used	use	VERB
ctmj-146	27	54	a	a	DET
ctmj-146	27	55	murine	murine	ADJ
ctmj-146	27	56	macrophage	macrophage	ADJ
ctmj-146	27	57	raw264.7	raw264.7	PROPN
ctmj-146	27	58	cell	cell	NOUN
ctmj-146	27	59	line	line	NOUN
ctmj-146	27	60	—	—	PUNCT
ctmj-146	27	61	which	which	PRON
ctmj-146	27	62	does	do	AUX
ctmj-146	27	63	not	not	PART
ctmj-146	27	64	contain	contain	VERB
ctmj-146	27	65	tumors	tumor	NOUN
ctmj-146	27	66	—	—	PUNCT
ctmj-146	27	67	to	to	PART
ctmj-146	27	68	demonstrate	demonstrate	VERB
ctmj-146	27	69	that	that	SCONJ
ctmj-146	27	70	the	the	DET
ctmj-146	27	71	medication	medication	NOUN
ctmj-146	27	72	blocks	block	VERB
ctmj-146	27	73	the	the	DET
ctmj-146	27	74	jak	jak	PROPN
ctmj-146	27	75	-	-	PUNCT
ctmj-146	27	76	stat	stat	PROPN
ctmj-146	27	77	pathway.22	pathway.22	NOUN
ctmj-146	27	78	there	there	PRON
ctmj-146	27	79	has	have	AUX
ctmj-146	27	80	been	be	AUX
ctmj-146	27	81	an	an	DET
ctmj-146	27	82	analogous	analogous	ADJ
ctmj-146	27	83	in	in	ADP
ctmj-146	27	84	vitro	vitro	X
ctmj-146	27	85	investigation	investigation	NOUN
ctmj-146	27	86	with	with	ADP
ctmj-146	27	87	glioblastoma	glioblastoma	NOUN
ctmj-146	27	88	cell	cell	NOUN
ctmj-146	27	89	lines.23	lines.23	PROPN
ctmj-146	27	90	cvb	cvb	PROPN
ctmj-146	27	91	-	-	PUNCT
ctmj-146	27	92	d	d	PROPN
ctmj-146	27	93	caused	cause	VERB
ctmj-146	27	94	apoptosis	apoptosis	NOUN
ctmj-146	27	95	,	,	PUNCT
ctmj-146	27	96	cell	cell	NOUN
ctmj-146	27	97	cycle	cycle	NOUN
ctmj-146	27	98	arrests	arrest	NOUN
ctmj-146	27	99	(	(	PUNCT
ctmj-146	27	100	in	in	ADP
ctmj-146	27	101	the	the	DET
ctmj-146	27	102	s	s	X
ctmj-146	27	103	and	and	CCONJ
ctmj-146	27	104	g0	g0	ADJ
ctmj-146	27	105	/	/	SYM
ctmj-146	27	106	g1	g1	PROPN
ctmj-146	27	107	phases	phase	NOUN
ctmj-146	27	108	)	)	PUNCT
ctmj-146	27	109	,	,	PUNCT
ctmj-146	27	110	and	and	CCONJ
ctmj-146	27	111	inhibition	inhibition	NOUN
ctmj-146	27	112	of	of	ADP
ctmj-146	27	113	glioma	glioma	NOUN
ctmj-146	27	114	cell	cell	NOUN
ctmj-146	27	115	growth	growth	NOUN
ctmj-146	27	116	in	in	ADP
ctmj-146	27	117	t98	t98	PROPN
ctmj-146	27	118	g	g	PROPN
ctmj-146	27	119	and	and	CCONJ
ctmj-146	27	120	hs683	hs683	NOUN
ctmj-146	27	121	models	model	NOUN
ctmj-146	27	122	.	.	PUNCT
ctmj-146	28	1	however	however	ADV
ctmj-146	28	2	,	,	PUNCT
ctmj-146	28	3	drug	drug	NOUN
ctmj-146	28	4	doses	dose	NOUN
ctmj-146	28	5	ranging	range	VERB
ctmj-146	28	6	from	from	ADP
ctmj-146	28	7	100	100	NUM
ctmj-146	28	8	to	to	PART
ctmj-146	28	9	200	200	NUM
ctmj-146	28	10	mm	mm	NOUN
ctmj-146	28	11	were	be	AUX
ctmj-146	28	12	required	require	VERB
ctmj-146	28	13	to	to	PART
ctmj-146	28	14	induce	induce	VERB
ctmj-146	28	15	a	a	DET
ctmj-146	28	16	significant	significant	ADJ
ctmj-146	28	17	amount	amount	NOUN
ctmj-146	28	18	of	of	ADP
ctmj-146	28	19	apoptosis	apoptosis	NOUN
ctmj-146	28	20	.	.	PUNCT
ctmj-146	29	1	the	the	DET
ctmj-146	29	2	sensitivity	sensitivity	NOUN
ctmj-146	29	3	of	of	ADP
ctmj-146	29	4	these	these	DET
ctmj-146	29	5	glioma	glioma	NOUN
ctmj-146	29	6	cells	cell	NOUN
ctmj-146	29	7	to	to	ADP
ctmj-146	29	8	cvb	cvb	PROPN
ctmj-146	29	9	-	-	PUNCT
ctmj-146	29	10	d	d	PROPN
ctmj-146	29	11	seems	seem	VERB
ctmj-146	29	12	to	to	PART
ctmj-146	29	13	be	be	AUX
ctmj-146	29	14	low	low	ADJ
ctmj-146	29	15	.	.	PUNCT
ctmj-146	30	1	nevertheless	nevertheless	ADV
ctmj-146	30	2	,	,	PUNCT
ctmj-146	30	3	this	this	PRON
ctmj-146	30	4	provides	provide	VERB
ctmj-146	30	5	more	more	ADJ
ctmj-146	30	6	evidence	evidence	NOUN
ctmj-146	30	7	that	that	SCONJ
ctmj-146	30	8	the	the	DET
ctmj-146	30	9	medication	medication	NOUN
ctmj-146	30	10	may	may	AUX
ctmj-146	30	11	inhibit	inhibit	VERB
ctmj-146	30	12	cell	cell	NOUN
ctmj-146	30	13	proliferation	proliferation	NOUN
ctmj-146	30	14	and	and	CCONJ
ctmj-146	30	15	promote	promote	VERB
ctmj-146	30	16	cell	cell	NOUN
ctmj-146	30	17	death	death	NOUN
ctmj-146	30	18	in	in	ADP
ctmj-146	30	19	response	response	NOUN
ctmj-146	30	20	to	to	ADP
ctmj-146	30	21	aggressive	aggressive	ADJ
ctmj-146	30	22	malignant	malignant	ADJ
ctmj-146	30	23	cells	cell	NOUN
ctmj-146	30	24	.	.	PUNCT
ctmj-146	31	1	using	use	VERB
ctmj-146	31	2	hepatocellular	hepatocellular	ADJ
ctmj-146	31	3	carcinoma	carcinoma	NOUN
ctmj-146	31	4	(	(	PUNCT
ctmj-146	31	5	hcc	hcc	NOUN
ctmj-146	31	6	)	)	PUNCT
ctmj-146	31	7	cells	cell	NOUN
ctmj-146	31	8	,	,	PUNCT
ctmj-146	31	9	researchers	researcher	NOUN
ctmj-146	31	10	have	have	AUX
ctmj-146	31	11	recently	recently	ADV
ctmj-146	31	12	shown	show	VERB
ctmj-146	31	13	that	that	SCONJ
ctmj-146	31	14	cvb	cvb	PROPN
ctmj-146	31	15	-	-	PROPN
ctmj-146	31	16	d	d	PROPN
ctmj-146	31	17	may	may	AUX
ctmj-146	31	18	inhibit	inhibit	VERB
ctmj-146	31	19	cell	cell	NOUN
ctmj-146	31	20	proliferation	proliferation	NOUN
ctmj-146	31	21	and	and	CCONJ
ctmj-146	31	22	induce	induce	VERB
ctmj-146	31	23	cell	cell	NOUN
ctmj-146	31	24	death.24	death.24	NOUN
ctmj-146	31	25	with	with	ADP
ctmj-146	31	26	an	an	DET
ctmj-146	31	27	ic50	ic50	PROPN
ctmj-146	31	28	of	of	ADP
ctmj-146	31	29	around	around	ADV
ctmj-146	31	30	15–17	15–17	NUM
ctmj-146	31	31	mm	mm	PROPN
ctmj-146	31	32	,	,	PUNCT
ctmj-146	31	33	cvb	cvb	PROPN
ctmj-146	31	34	-	-	PUNCT
ctmj-146	31	35	d	d	PROPN
ctmj-146	31	36	treatment	treatment	NOUN
ctmj-146	31	37	inhibited	inhibit	VERB
ctmj-146	31	38	the	the	DET
ctmj-146	31	39	proliferation	proliferation	NOUN
ctmj-146	31	40	of	of	ADP
ctmj-146	31	41	hepg2	hepg2	NOUN
ctmj-146	31	42	and	and	CCONJ
ctmj-146	31	43	hcclm3	hcclm3	NOUN
ctmj-146	31	44	cells	cell	NOUN
ctmj-146	31	45	in	in	ADP
ctmj-146	31	46	a	a	DET
ctmj-146	31	47	dose	dose	NOUN
ctmj-146	31	48	-	-	PUNCT
ctmj-146	31	49	dependent	dependent	ADJ
ctmj-146	31	50	manner	manner	NOUN
ctmj-146	31	51	,	,	PUNCT
ctmj-146	31	52	whereas	whereas	SCONJ
ctmj-146	31	53	lower	low	ADJ
ctmj-146	31	54	drug	drug	NOUN
ctmj-146	31	55	concentrations	concentration	NOUN
ctmj-146	31	56	resulted	result	VERB
ctmj-146	31	57	in	in	ADP
ctmj-146	31	58	impaired	impaired	ADJ
ctmj-146	31	59	colony	colony	NOUN
ctmj-146	31	60	formation	formation	NOUN
ctmj-146	31	61	.	.	PUNCT
ctmj-146	32	1	at	at	ADP
ctmj-146	32	2	doses	dose	NOUN
ctmj-146	32	3	ranging	range	VERB
ctmj-146	32	4	from	from	ADP
ctmj-146	32	5	10	10	NUM
ctmj-146	32	6	to	to	PART
ctmj-146	32	7	40	40	NUM
ctmj-146	32	8	mm	mm	NUM
ctmj-146	32	9	,	,	PUNCT
ctmj-146	32	10	cvb	cvb	PROPN
ctmj-146	32	11	-	-	PUNCT
ctmj-146	32	12	d	d	PROPN
ctmj-146	32	13	was	be	AUX
ctmj-146	32	14	seen	see	VERB
ctmj-146	32	15	to	to	PART
ctmj-146	32	16	trigger	trigger	VERB
ctmj-146	32	17	a	a	DET
ctmj-146	32	18	significant	significant	ADJ
ctmj-146	32	19	death	death	NOUN
ctmj-146	32	20	of	of	ADP
ctmj-146	32	21	hcc	hcc	PROPN
ctmj-146	32	22	cells	cell	NOUN
ctmj-146	32	23	,	,	PUNCT
ctmj-146	32	24	just	just	ADV
ctmj-146	32	25	as	as	SCONJ
ctmj-146	32	26	it	it	PRON
ctmj-146	32	27	did	do	VERB
ctmj-146	32	28	in	in	ADP
ctmj-146	32	29	the	the	DET
ctmj-146	32	30	gastric	gastric	ADJ
ctmj-146	32	31	cell	cell	NOUN
ctmj-146	32	32	line	line	NOUN
ctmj-146	32	33	.	.	PUNCT
ctmj-146	33	1	the	the	DET
ctmj-146	33	2	potency	potency	NOUN
ctmj-146	33	3	is	be	AUX
ctmj-146	33	4	moderate	moderate	ADJ
ctmj-146	33	5	.	.	PUNCT
ctmj-146	34	1	however	however	ADV
ctmj-146	34	2	,	,	PUNCT
ctmj-146	34	3	the	the	DET
ctmj-146	34	4	fact	fact	NOUN
ctmj-146	34	5	that	that	SCONJ
ctmj-146	34	6	the	the	DET
ctmj-146	34	7	research	research	NOUN
ctmj-146	34	8	also	also	ADV
ctmj-146	34	9	documented	document	VERB
ctmj-146	34	10	the	the	DET
ctmj-146	34	11	drug	drug	NOUN
ctmj-146	34	12	's	's	PART
ctmj-146	34	13	action	action	NOUN
ctmj-146	34	14	in	in	ADP
ctmj-146	34	15	living	live	VERB
ctmj-146	34	16	organisms	organism	NOUN
ctmj-146	34	17	makes	make	VERB
ctmj-146	34	18	it	it	PRON
ctmj-146	34	19	noteworthy	noteworthy	ADJ
ctmj-146	34	20	.	.	PUNCT
ctmj-146	35	1	mice	mouse	NOUN
ctmj-146	35	2	with	with	ADP
ctmj-146	35	3	hepg2	hepg2	NOUN
ctmj-146	35	4	tumors	tumor	NOUN
ctmj-146	35	5	showed	show	VERB
ctmj-146	35	6	an	an	DET
ctmj-146	35	7	increase	increase	NOUN
ctmj-146	35	8	in	in	ADP
ctmj-146	35	9	the	the	DET
ctmj-146	35	10	rate	rate	NOUN
ctmj-146	35	11	of	of	ADP
ctmj-146	35	12	tumor	tumor	NOUN
ctmj-146	35	13	cell	cell	NOUN
ctmj-146	35	14	death	death	NOUN
ctmj-146	35	15	and	and	CCONJ
ctmj-146	35	16	a	a	DET
ctmj-146	35	17	significant	significant	ADJ
ctmj-146	35	18	decrease	decrease	NOUN
ctmj-146	35	19	in	in	ADP
ctmj-146	35	20	tumor	tumor	NOUN
ctmj-146	35	21	volume	volume	NOUN
ctmj-146	35	22	after	after	ADP
ctmj-146	35	23	receiving	receive	VERB
ctmj-146	35	24	intraperitoneal	intraperitoneal	ADJ
ctmj-146	35	25	administration	administration	NOUN
ctmj-146	35	26	of	of	ADP
ctmj-146	35	27	cvb	cvb	PROPN
ctmj-146	35	28	-	-	PROPN
ctmj-146	35	29	d	d	PROPN
ctmj-146	35	30	(	(	PUNCT
ctmj-146	35	31	10	10	NUM
ctmj-146	35	32	mg	mg	NUM
ctmj-146	35	33	/	/	SYM
ctmj-146	35	34	kg	kg	PROPN
ctmj-146	35	35	,	,	PUNCT
ctmj-146	35	36	every	every	DET
ctmj-146	35	37	two	two	NUM
ctmj-146	35	38	days	day	NOUN
ctmj-146	35	39	,	,	PUNCT
ctmj-146	35	40	for	for	ADP
ctmj-146	35	41	14	14	NUM
ctmj-146	35	42	days	day	NOUN
ctmj-146	35	43	)	)	PUNCT
ctmj-146	35	44	.	.	PUNCT
ctmj-146	36	1	the	the	DET
ctmj-146	36	2	medicine	medicine	NOUN
ctmj-146	36	3	effectively	effectively	ADV
ctmj-146	36	4	reduced	reduce	VERB
ctmj-146	36	5	tumor	tumor	NOUN
ctmj-146	36	6	development	development	NOUN
ctmj-146	36	7	in	in	ADP
ctmj-146	36	8	mice	mouse	NOUN
ctmj-146	36	9	and	and	CCONJ
ctmj-146	36	10	seemed	seem	VERB
ctmj-146	36	11	to	to	PART
ctmj-146	36	12	be	be	AUX
ctmj-146	36	13	well	well	ADV
ctmj-146	36	14	-	-	PUNCT
ctmj-146	36	15	tolerated	tolerate	VERB
ctmj-146	36	16	(	(	PUNCT
ctmj-146	36	17	treated	treat	VERB
ctmj-146	36	18	animals	animal	NOUN
ctmj-146	36	19	did	do	AUX
ctmj-146	36	20	not	not	PART
ctmj-146	36	21	lose	lose	VERB
ctmj-146	36	22	weight	weight	NOUN
ctmj-146	36	23	)	)	PUNCT
ctmj-146	36	24	.	.	PUNCT
ctmj-146	37	1	thus	thus	ADV
ctmj-146	37	2	,	,	PUNCT
ctmj-146	37	3	the	the	DET
ctmj-146	37	4	anticancer	anticancer	NOUN
ctmj-146	37	5	effect	effect	NOUN
ctmj-146	37	6	is	be	AUX
ctmj-146	37	7	associated	associate	VERB
ctmj-146	37	8	with	with	ADP
ctmj-146	37	9	a	a	DET
ctmj-146	37	10	medication	medication	NOUN
ctmj-146	37	11	-	-	PUNCT
ctmj-146	37	12	induced	induce	VERB
ctmj-146	37	13	suppression	suppression	NOUN
ctmj-146	37	14	of	of	ADP
ctmj-146	37	15	the	the	DET
ctmj-146	37	16	egfr	egfr	ADJ
ctmj-146	37	17	-	-	PUNCT
ctmj-146	37	18	fak	fak	PROPN
ctmj-146	37	19	-	-	PUNCT
ctmj-146	37	20	akt	akt	PROPN
ctmj-146	37	21	/	/	SYM
ctmj-146	37	22	erk1/2slug	erk1/2slug	NOUN
ctmj-146	37	23	signaling	signal	VERB
ctmj-146	37	24	pathway	pathway	NOUN
ctmj-146	37	25	,	,	PUNCT
ctmj-146	37	26	as	as	SCONJ
ctmj-146	37	27	shown	show	VERB
ctmj-146	37	28	by	by	ADP
ctmj-146	37	29	biochemical	biochemical	ADJ
ctmj-146	37	30	tests	test	NOUN
ctmj-146	37	31	indicating	indicate	VERB
ctmj-146	37	32	the	the	DET
ctmj-146	37	33	drug	drug	NOUN
ctmj-146	37	34	could	could	AUX
ctmj-146	37	35	diminish	diminish	VERB
ctmj-146	37	36	phosphorylation	phosphorylation	NOUN
ctmj-146	37	37	of	of	ADP
ctmj-146	37	38	egfr	egfr	NOUN
ctmj-146	37	39	,	,	PUNCT
ctmj-146	37	40	akt	akt	PROPN
ctmj-146	37	41	,	,	PUNCT
ctmj-146	37	42	and	and	CCONJ
ctmj-146	37	43	erk1/2	erk1/2	PROPN
ctmj-146	37	44	in	in	ADP
ctmj-146	37	45	hcc	hcc	PROPN
ctmj-146	37	46	cells	cell	NOUN
ctmj-146	37	47	in	in	ADP
ctmj-146	37	48	vitro.24	vitro.24	PROPN
ctmj-146	37	49	a	a	DET
ctmj-146	37	50	comparable	comparable	ADJ
ctmj-146	37	51	study	study	NOUN
ctmj-146	37	52	using	use	VERB
ctmj-146	37	53	cells	cell	NOUN
ctmj-146	37	54	from	from	ADP
ctmj-146	37	55	colorectal	colorectal	ADJ
ctmj-146	37	56	cancer	cancer	NOUN
ctmj-146	37	57	was	be	AUX
ctmj-146	37	58	reported	report	VERB
ctmj-146	37	59	not	not	PART
ctmj-146	37	60	long	long	ADJ
ctmj-146	38	1	ago.cell	ago.cell	ADJ
ctmj-146	38	2	colonies	colony	NOUN
ctmj-146	38	3	are	be	AUX
ctmj-146	38	4	formed	form	VERB
ctmj-146	38	5	and	and	CCONJ
ctmj-146	38	6	dld-1	dld-1	PUNCT
ctmj-146	38	7	and	and	CCONJ
ctmj-146	38	8	lovo	lovo	PROPN
ctmj-146	38	9	cell	cell	NOUN
ctmj-146	38	10	proliferation	proliferation	NOUN
ctmj-146	38	11	is	be	AUX
ctmj-146	38	12	reduced	reduce	VERB
ctmj-146	38	13	by	by	ADP
ctmj-146	38	14	25	25	NUM
ctmj-146	38	15	cvb	cvb	PROPN
ctmj-146	38	16	-	-	PROPN
ctmj-146	38	17	d	d	PROPN
ctmj-146	38	18	with	with	ADP
ctmj-146	38	19	an	an	DET
ctmj-146	38	20	ic50	ic50	PROPN
ctmj-146	38	21	of	of	ADP
ctmj-146	38	22	23–26	23–26	NUM
ctmj-146	38	23	mm	mm	NOUN
ctmj-146	38	24	.	.	PUNCT
ctmj-146	38	25	vimentin	vimentin	PROPN
ctmj-146	38	26	and	and	CCONJ
ctmj-146	38	27	n	n	CCONJ
ctmj-146	38	28	-	-	PUNCT
ctmj-146	38	29	cadherin	cadherin	NOUN
ctmj-146	38	30	are	be	AUX
ctmj-146	38	31	important	important	ADJ
ctmj-146	38	32	indicators	indicator	NOUN
ctmj-146	38	33	of	of	ADP
ctmj-146	38	34	the	the	DET
ctmj-146	38	35	drug	drug	NOUN
ctmj-146	38	36	-	-	PUNCT
ctmj-146	38	37	induced	induce	VERB
ctmj-146	38	38	epithelial	epithelial	ADJ
ctmj-146	38	39	-	-	PUNCT
ctmj-146	38	40	mesenchymal	mesenchymal	NOUN
ctmj-146	38	41	transition	transition	NOUN
ctmj-146	38	42	(	(	PUNCT
ctmj-146	38	43	emt	emt	PROPN
ctmj-146	38	44	)	)	PUNCT
ctmj-146	38	45	,	,	PUNCT
ctmj-146	38	46	and	and	CCONJ
ctmj-146	38	47	the	the	DET
ctmj-146	38	48	medication	medication	NOUN
ctmj-146	38	49	decreased	decrease	VERB
ctmj-146	38	50	their	their	PRON
ctmj-146	38	51	expression	expression	NOUN
ctmj-146	38	52	in	in	ADP
ctmj-146	38	53	both	both	DET
ctmj-146	38	54	cell	cell	NOUN
ctmj-146	38	55	types	type	NOUN
ctmj-146	38	56	in	in	ADP
ctmj-146	38	57	a	a	DET
ctmj-146	38	58	dosedependent	dosedependent	NOUN
ctmj-146	38	59	manner	manner	NOUN
ctmj-146	38	60	while	while	SCONJ
ctmj-146	38	61	boosting	boost	VERB
ctmj-146	38	62	e	e	NOUN
ctmj-146	38	63	-	-	NOUN
ctmj-146	38	64	cadherin	cadherin	NOUN
ctmj-146	38	65	's	's	PART
ctmj-146	38	66	expression	expression	NOUN
ctmj-146	38	67	.	.	PUNCT
ctmj-146	39	1	in	in	ADP
ctmj-146	39	2	order	order	NOUN
ctmj-146	39	3	to	to	PART
ctmj-146	39	4	decrease	decrease	VERB
ctmj-146	39	5	tumor	tumor	NOUN
ctmj-146	39	6	cell	cell	NOUN
ctmj-146	39	7	invasion	invasion	NOUN
ctmj-146	39	8	and	and	CCONJ
ctmj-146	39	9	dissemination	dissemination	NOUN
ctmj-146	39	10	via	via	ADP
ctmj-146	39	11	blood	blood	NOUN
ctmj-146	39	12	and	and	CCONJ
ctmj-146	39	13	lymphatic	lymphatic	ADJ
ctmj-146	39	14	vessels	vessel	NOUN
ctmj-146	39	15	,	,	PUNCT
ctmj-146	39	16	the	the	DET
ctmj-146	39	17	medication	medication	NOUN
ctmj-146	39	18	protects	protect	VERB
ctmj-146	39	19	the	the	DET
ctmj-146	39	20	extracellular	extracellular	ADJ
ctmj-146	39	21	matrix	matrix	NOUN
ctmj-146	39	22	.	.	PUNCT
ctmj-146	40	1	by	by	ADP
ctmj-146	40	2	inhibiting	inhibit	VERB
ctmj-146	40	3	matrix	matrix	NOUN
ctmj-146	40	4	metalloproteinases	metalloproteinase	NOUN
ctmj-146	40	5	mmp2	mmp2	ADJ
ctmj-146	40	6	and	and	CCONJ
ctmj-146	40	7	mmp9	mmp9	VERB
ctmj-146	40	8	and	and	CCONJ
ctmj-146	40	9	downregulating	downregulating	NOUN
ctmj-146	40	10	effector	effector	NOUN
ctmj-146	40	11	proteins	protein	NOUN
ctmj-146	40	12	including	include	VERB
ctmj-146	40	13	snail	snail	NOUN
ctmj-146	40	14	,	,	PUNCT
ctmj-146	40	15	slug	slug	NOUN
ctmj-146	40	16	,	,	PUNCT
ctmj-146	40	17	and	and	CCONJ
ctmj-146	40	18	zeb	zeb	PROPN
ctmj-146	40	19	,	,	PUNCT
ctmj-146	40	20	cvb	cvb	PROPN
ctmj-146	40	21	-	-	PUNCT
ctmj-146	40	22	d	d	PROPN
ctmj-146	40	23	can	can	AUX
ctmj-146	40	24	control	control	VERB
ctmj-146	40	25	emt	emt	PROPN
ctmj-146	40	26	.	.	PUNCT
ctmj-146	41	1	cvb	cvb	PROPN
ctmj-146	41	2	-	-	PUNCT
ctmj-146	41	3	d	d	PROPN
ctmj-146	41	4	also	also	ADV
ctmj-146	41	5	decreased	decrease	VERB
ctmj-146	41	6	cancer	cancer	NOUN
ctmj-146	41	7	cell	cell	NOUN
ctmj-146	41	8	motility	motility	NOUN
ctmj-146	41	9	and	and	CCONJ
ctmj-146	41	10	induced	induce	VERB
ctmj-146	41	11	cell	cell	NOUN
ctmj-146	41	12	death	death	NOUN
ctmj-146	41	13	by	by	ADP
ctmj-146	41	14	changing	change	VERB
ctmj-146	41	15	the	the	DET
ctmj-146	41	16	expression	expression	NOUN
ctmj-146	41	17	of	of	ADP
ctmj-146	41	18	the	the	DET
ctmj-146	41	19	up	up	ADV
ctmj-146	41	20	-	-	PUNCT
ctmj-146	41	21	regulated	regulate	VERB
ctmj-146	41	22	bax	bax	NOUN
ctmj-146	41	23	protein	protein	NOUN
ctmj-146	41	24	and	and	CCONJ
ctmj-146	41	25	the	the	DET
ctmj-146	41	26	downregulated	downregulate	VERB
ctmj-146	41	27	bcl-2	bcl-2	VERB
ctmj-146	41	28	protein	protein	NOUN
ctmj-146	41	29	,	,	PUNCT
ctmj-146	41	30	respectively	respectively	ADV
ctmj-146	41	31	.	.	PUNCT
ctmj-146	42	1	there	there	PRON
ctmj-146	42	2	was	be	VERB
ctmj-146	42	3	a	a	DET
ctmj-146	42	4	clear	clear	ADJ
ctmj-146	42	5	reduction	reduction	NOUN
ctmj-146	42	6	in	in	ADP
ctmj-146	42	7	akt	akt	PROPN
ctmj-146	42	8	and	and	CCONJ
ctmj-146	42	9	erk-1/2	erk-1/2	PROPN
ctmj-146	42	10	phosphorylation	phosphorylation	NOUN
ctmj-146	42	11	,	,	PUNCT
ctmj-146	42	12	which	which	PRON
ctmj-146	42	13	points	point	VERB
ctmj-146	42	14	to	to	ADP
ctmj-146	42	15	the	the	DET
ctmj-146	42	16	pi3k	pi3k	PROPN
ctmj-146	42	17	/	/	SYM
ctmj-146	42	18	akt	akt	PROPN
ctmj-146	42	19	/	/	SYM
ctmj-146	42	20	erk	erk	PROPN
ctmj-146	42	21	signaling	signal	VERB
ctmj-146	42	22	pathway	pathway	NOUN
ctmj-146	42	23	as	as	ADP
ctmj-146	42	24	the	the	DET
ctmj-146	42	25	primary	primary	ADJ
ctmj-146	42	26	mechanism	mechanism	NOUN
ctmj-146	42	27	by	by	ADP
ctmj-146	42	28	which	which	PRON
ctmj-146	42	29	the	the	DET
ctmj-146	42	30	medication	medication	NOUN
ctmj-146	42	31	exerts	exert	VERB
ctmj-146	42	32	its	its	PRON
ctmj-146	42	33	anticancer	anticancer	NOUN
ctmj-146	42	34	effects	effect	NOUN
ctmj-146	42	35	.	.	PUNCT
ctmj-146	43	1	it	it	PRON
ctmj-146	43	2	is	be	AUX
ctmj-146	43	3	worth	worth	ADJ
ctmj-146	43	4	noting	note	VERB
ctmj-146	43	5	that	that	SCONJ
ctmj-146	43	6	a	a	DET
ctmj-146	43	7	key	key	ADJ
ctmj-146	43	8	protein	protein	NOUN
ctmj-146	43	9	involved	involve	VERB
ctmj-146	43	10	in	in	ADP
ctmj-146	43	11	the	the	DET
ctmj-146	43	12	anticancer	anticancer	NOUN
ctmj-146	43	13	effect	effect	NOUN
ctmj-146	43	14	was	be	AUX
ctmj-146	43	15	identified	identify	VERB
ctmj-146	43	16	:	:	PUNCT
ctmj-146	43	17	cthrc1	cthrc1	PROPN
ctmj-146	43	18	,	,	PUNCT
ctmj-146	43	19	which	which	PRON
ctmj-146	43	20	stands	stand	VERB
ctmj-146	43	21	for	for	ADP
ctmj-146	43	22	collagen	collagen	NOUN
ctmj-146	43	23	triple	triple	ADJ
ctmj-146	43	24	helix	helix	ADJ
ctmj-146	43	25	repeat	repeat	NOUN
ctmj-146	43	26	containing	contain	VERB
ctmj-146	43	27	1	1	NUM
ctmj-146	43	28	.	.	PUNCT
ctmj-146	44	1	this	this	DET
ctmj-146	44	2	protein	protein	NOUN
ctmj-146	44	3	is	be	AUX
ctmj-146	44	4	often	often	ADV
ctmj-146	44	5	overexpressed	overexpresse	VERB
ctmj-146	44	6	in	in	ADP
ctmj-146	44	7	cancerous	cancerous	ADJ
ctmj-146	44	8	cells	cell	NOUN
ctmj-146	44	9	.	.	PUNCT
ctmj-146	45	1	cancer	cancer	NOUN
ctmj-146	45	2	cell	cell	NOUN
ctmj-146	45	3	motility	motility	NOUN
ctmj-146	45	4	,	,	PUNCT
ctmj-146	45	5	colony	colony	NOUN
ctmj-146	45	6	formation	formation	NOUN
ctmj-146	45	7	,	,	PUNCT
ctmj-146	45	8	invasion	invasion	NOUN
ctmj-146	45	9	,	,	PUNCT
ctmj-146	45	10	and	and	CCONJ
ctmj-146	45	11	proliferation	proliferation	NOUN
ctmj-146	45	12	are	be	AUX
ctmj-146	45	13	all	all	PRON
ctmj-146	45	14	facilitated	facilitate	VERB
ctmj-146	45	15	by	by	ADP
ctmj-146	45	16	this	this	DET
ctmj-146	45	17	protein	protein	NOUN
ctmj-146	45	18	,	,	PUNCT
ctmj-146	45	19	making	make	VERB
ctmj-146	45	20	it	it	PRON
ctmj-146	45	21	an	an	DET
ctmj-146	45	22	important	important	ADJ
ctmj-146	45	23	mediator	mediator	NOUN
ctmj-146	45	24	of	of	ADP
ctmj-146	45	25	oncogenesis.cvb	oncogenesis.cvb	PROPN
ctmj-146	45	26	-	-	PROPN
ctmj-146	45	27	d	d	NOUN
ctmj-146	45	28	can	can	AUX
ctmj-146	45	29	significantly	significantly	ADV
ctmj-146	45	30	downregulate	downregulate	VERB
ctmj-146	45	31	cthrc1	cthrc1	PROPN
ctmj-146	45	32	expression	expression	NOUN
ctmj-146	45	33	in	in	ADP
ctmj-146	45	34	dld-1	dld-1	PUNCT
ctmj-146	45	35	and	and	CCONJ
ctmj-146	45	36	lovo	lovo	PROPN
ctmj-146	45	37	cells	cell	NOUN
ctmj-146	45	38	,	,	PUNCT
ctmj-146	45	39	which	which	PRON
ctmj-146	45	40	in	in	ADP
ctmj-146	45	41	turn	turn	NOUN
ctmj-146	45	42	causes	cause	VERB
ctmj-146	45	43	phospho	phospho	ADJ
ctmj-146	45	44	-	-	PUNCT
ctmj-146	45	45	akt	akt	NOUN
ctmj-146	45	46	and	and	CCONJ
ctmj-146	45	47	phosphoerk	phosphoerk	VERB
ctmj-146	45	48	to	to	PART
ctmj-146	45	49	disappear	disappear	VERB
ctmj-146	45	50	.	.	PUNCT
ctmj-146	46	1	cvb	cvb	PROPN
ctmj-146	46	2	-	-	PROPN
ctmj-146	46	3	d	d	PROPN
ctmj-146	46	4	may	may	AUX
ctmj-146	46	5	have	have	VERB
ctmj-146	46	6	an	an	DET
ctmj-146	46	7	upstream	upstream	ADJ
ctmj-146	46	8	target	target	NOUN
ctmj-146	46	9	in	in	ADP
ctmj-146	46	10	cthrc1	cthrc1	PROPN
ctmj-146	46	11	,	,	PUNCT
ctmj-146	46	12	according	accord	VERB
ctmj-146	46	13	to	to	ADP
ctmj-146	46	14	the	the	DET
ctmj-146	46	15	authors	author	NOUN
ctmj-146	46	16	'	'	PART
ctmj-146	46	17	findings.25	findings.25	NOUN
ctmj-146	46	18	this	this	DET
ctmj-146	46	19	anticancer	anticancer	NOUN
ctmj-146	46	20	fig	fig	NOUN
ctmj-146	46	21	.	.	PUNCT
ctmj-146	47	1	1	1	X
ctmj-146	47	2	.	.	X
ctmj-146	47	3	structure	structure	NOUN
ctmj-146	47	4	of	of	ADP
ctmj-146	47	5	cyclovirobuxine	cyclovirobuxine	PROPN
ctmj-146	47	6	d	d	PROPN
ctmj-146	47	7	(	(	PUNCT
ctmj-146	47	8	cvb	cvb	PROPN
ctmj-146	47	9	-	-	PUNCT
ctmj-146	47	10	d	d	NOUN
ctmj-146	47	11	)	)	PUNCT
ctmj-146	47	12	isolated	isolate	VERB
ctmj-146	47	13	from	from	ADP
ctmj-146	47	14	buxus	buxus	NOUN
ctmj-146	47	15	microphylla	microphylla	NOUN
ctmj-146	47	16	.	.	PUNCT
ctmj-146	48	1	cvb	cvb	PROPN
ctmj-146	48	2	-	-	PUNCT
ctmj-146	48	3	d	d	PROPN
ctmj-146	48	4	is	be	AUX
ctmj-146	48	5	the	the	DET
ctmj-146	48	6	active	active	ADJ
ctmj-146	48	7	pharmaceutical	pharmaceutical	ADJ
ctmj-146	48	8	ingredient	ingredient	NOUN
ctmj-146	48	9	of	of	ADP
ctmj-146	48	10	the	the	DET
ctmj-146	48	11	drug	drug	NOUN
ctmj-146	48	12	huangyangning	huangyangne	VERB
ctmj-146	48	13	tablets	tablet	NOUN
ctmj-146	48	14	used	use	VERB
ctmj-146	48	15	in	in	ADP
ctmj-146	48	16	china	china	PROPN
ctmj-146	48	17	to	to	PART
ctmj-146	48	18	treat	treat	VERB
ctmj-146	48	19	cardiovascular	cardiovascular	ADJ
ctmj-146	48	20	diseases	disease	NOUN
ctmj-146	48	21	.	.	PUNCT
ctmj-146	49	1	cvb	cvb	PROPN
ctmj-146	49	2	-	-	PUNCT
ctmj-146	49	3	d	d	PROPN
ctmj-146	49	4	is	be	AUX
ctmj-146	49	5	also	also	ADV
ctmj-146	49	6	known	know	VERB
ctmj-146	49	7	as	as	ADP
ctmj-146	49	8	cyclovirobuxinum	cyclovirobuxinum	PROPN
ctmj-146	49	9	d	d	NOUN
ctmj-146	49	10	or	or	CCONJ
ctmj-146	49	11	bebuxine	bebuxine	PROPN
ctmj-146	49	12	(	(	PUNCT
ctmj-146	49	13	c26h46n2o	c26h46n2o	PROPN
ctmj-146	49	14	)	)	PUNCT
ctmj-146	49	15	and	and	CCONJ
ctmj-146	49	16	is	be	AUX
ctmj-146	49	17	listed	list	VERB
ctmj-146	49	18	in	in	ADP
ctmj-146	49	19	the	the	DET
ctmj-146	49	20	pharmacopoeia	pharmacopoeia	NOUN
ctmj-146	49	21	of	of	ADP
ctmj-146	49	22	the	the	DET
ctmj-146	49	23	people	people	NOUN
ctmj-146	49	24	’s	’s	PART
ctmj-146	49	25	republic	republic	PROPN
ctmj-146	49	26	of	of	ADP
ctmj-146	49	27	china	china	PROPN
ctmj-146	49	28	(	(	PUNCT
ctmj-146	49	29	edition	edition	NOUN
ctmj-146	49	30	2015	2015	NUM
ctmj-146	49	31	)	)	PUNCT
ctmj-146	49	32	.	.	PUNCT
ctmj-146	50	1	cvb	cvb	PROPN
ctmj-146	50	2	-	-	PUNCT
ctmj-146	50	3	d	d	PROPN
ctmj-146	50	4	's	's	PART
ctmj-146	50	5	activity	activity	NOUN
ctmj-146	50	6	was	be	AUX
ctmj-146	50	7	studied	study	VERB
ctmj-146	50	8	in	in	ADP
ctmj-146	50	9	vivo	vivo	NOUN
ctmj-146	50	10	by	by	ADP
ctmj-146	50	11	xenografting	xenografte	VERB
ctmj-146	50	12	dld-1	dld-1	PART
ctmj-146	50	13	cancer	cancer	NOUN
ctmj-146	50	14	cells	cell	NOUN
ctmj-146	50	15	into	into	ADP
ctmj-146	50	16	mice	mouse	NOUN
ctmj-146	50	17	.	.	PUNCT
ctmj-146	51	1	the	the	DET
ctmj-146	51	2	tumor	tumor	NOUN
ctmj-146	51	3	volume	volume	NOUN
ctmj-146	51	4	was	be	AUX
ctmj-146	51	5	significantly	significantly	ADV
ctmj-146	51	6	decreased	decrease	VERB
ctmj-146	51	7	and	and	CCONJ
ctmj-146	51	8	the	the	DET
ctmj-146	51	9	residual	residual	ADJ
ctmj-146	51	10	tumor	tumor	NOUN
ctmj-146	51	11	showed	show	VERB
ctmj-146	51	12	evident	evident	ADJ
ctmj-146	51	13	symptoms	symptom	NOUN
ctmj-146	51	14	of	of	ADP
ctmj-146	51	15	drug	drug	NOUN
ctmj-146	51	16	-	-	PUNCT
ctmj-146	51	17	induced	induce	VERB
ctmj-146	51	18	apoptosis	apoptosis	NOUN
ctmj-146	51	19	after	after	ADP
ctmj-146	51	20	four	four	NUM
ctmj-146	51	21	weeks	week	NOUN
ctmj-146	51	22	of	of	ADP
ctmj-146	51	23	intraperitoneal	intraperitoneal	ADJ
ctmj-146	51	24	injection	injection	NOUN
ctmj-146	51	25	of	of	ADP
ctmj-146	51	26	cvb	cvb	PROPN
ctmj-146	51	27	-	-	PROPN
ctmj-146	51	28	d	d	PROPN
ctmj-146	51	29	(	(	PUNCT
ctmj-146	51	30	15	15	NUM
ctmj-146	51	31	mg	mg	PROPN
ctmj-146	51	32	/	/	SYM
ctmj-146	51	33	kg	kg	PROPN
ctmj-146	51	34	/	/	SYM
ctmj-146	51	35	day	day	NOUN
ctmj-146	51	36	)	)	PUNCT
ctmj-146	51	37	.	.	PUNCT
ctmj-146	52	1	this	this	DET
ctmj-146	52	2	new	new	ADJ
ctmj-146	52	3	research	research	NOUN
ctmj-146	52	4	not	not	PART
ctmj-146	52	5	only	only	ADV
ctmj-146	52	6	backs	back	VERB
ctmj-146	52	7	up	up	ADP
ctmj-146	52	8	cvb	cvb	PROPN
ctmj-146	52	9	-	-	PUNCT
ctmj-146	52	10	d	d	PROPN
ctmj-146	52	11	's	's	PART
ctmj-146	52	12	anticancer	anticancer	NOUN
ctmj-146	52	13	claims	claim	NOUN
ctmj-146	52	14	in	in	ADP
ctmj-146	52	15	colon	colon	NOUN
ctmj-146	52	16	cancer	cancer	NOUN
ctmj-146	52	17	,	,	PUNCT
ctmj-146	52	18	but	but	CCONJ
ctmj-146	52	19	it	it	PRON
ctmj-146	52	20	also	also	ADV
ctmj-146	52	21	lays	lay	VERB
ctmj-146	52	22	out	out	ADP
ctmj-146	52	23	crucial	crucial	ADJ
ctmj-146	52	24	molecular	molecular	ADJ
ctmj-146	52	25	details	detail	NOUN
ctmj-146	52	26	,	,	PUNCT
ctmj-146	52	27	such	such	ADJ
ctmj-146	52	28	as	as	ADP
ctmj-146	52	29	how	how	SCONJ
ctmj-146	52	30	the	the	DET
ctmj-146	52	31	secreted	secrete	VERB
ctmj-146	52	32	glycoprotein	glycoprotein	NOUN
ctmj-146	52	33	cthrc1	cthrc1	NOUN
ctmj-146	52	34	is	be	AUX
ctmj-146	52	35	a	a	DET
ctmj-146	52	36	potential	potential	ADJ
ctmj-146	52	37	target	target	NOUN
ctmj-146	52	38	for	for	ADP
ctmj-146	52	39	cvb	cvb	PROPN
ctmj-146	52	40	-	-	PROPN
ctmj-146	52	41	d	d	PROPN
ctmj-146	52	42	and	and	CCONJ
ctmj-146	52	43	a	a	DET
ctmj-146	52	44	major	major	ADJ
ctmj-146	52	45	driver	driver	NOUN
ctmj-146	52	46	of	of	ADP
ctmj-146	52	47	its	its	PRON
ctmj-146	52	48	anticancer	anticancer	NOUN
ctmj-146	52	49	impact	impact	NOUN
ctmj-146	52	50	.	.	PUNCT
ctmj-146	53	1	it	it	PRON
ctmj-146	53	2	may	may	AUX
ctmj-146	53	3	also	also	ADV
ctmj-146	53	4	function	function	VERB
ctmj-146	53	5	as	as	ADP
ctmj-146	53	6	an	an	DET
ctmj-146	53	7	effector	effector	NOUN
ctmj-146	53	8	,	,	PUNCT
ctmj-146	53	9	changing	change	VERB
ctmj-146	53	10	its	its	PRON
ctmj-146	53	11	state	state	NOUN
ctmj-146	53	12	in	in	ADP
ctmj-146	53	13	reaction	reaction	NOUN
ctmj-146	53	14	to	to	ADP
ctmj-146	53	15	cvb	cvb	PROPN
ctmj-146	53	16	-	-	PUNCT
ctmj-146	53	17	d	d	PROPN
ctmj-146	53	18	's	's	PART
ctmj-146	53	19	influence	influence	NOUN
ctmj-146	53	20	on	on	ADP
ctmj-146	53	21	a	a	DET
ctmj-146	53	22	target	target	NOUN
ctmj-146	53	23	farther	far	ADV
ctmj-146	53	24	upstream	upstream	ADJ
ctmj-146	53	25	.	.	PUNCT
ctmj-146	54	1	so	so	ADV
ctmj-146	54	2	far	far	ADV
ctmj-146	54	3	,	,	PUNCT
ctmj-146	54	4	five	five	NUM
ctmj-146	54	5	separate	separate	ADJ
ctmj-146	54	6	investigations	investigation	NOUN
ctmj-146	54	7	have	have	AUX
ctmj-146	54	8	shown	show	VERB
ctmj-146	54	9	that	that	SCONJ
ctmj-146	54	10	cvb	cvb	PROPN
ctmj-146	54	11	-	-	PUNCT
ctmj-146	54	12	d	d	PROPN
ctmj-146	54	13	has	have	VERB
ctmj-146	54	14	anticancer	anticancer	NOUN
ctmj-146	54	15	effects	effect	NOUN
ctmj-146	54	16	in	in	ADP
ctmj-146	54	17	various	various	ADJ
ctmj-146	54	18	animal	animal	NOUN
ctmj-146	54	19	models	model	NOUN
ctmj-146	54	20	(	(	PUNCT
ctmj-146	54	21	table	table	NOUN
ctmj-146	54	22	1	1	NUM
ctmj-146	54	23	)	)	PUNCT
ctmj-146	54	24	.	.	PUNCT
ctmj-146	55	1	two	two	NUM
ctmj-146	55	2	in	in	ADP
ctmj-146	55	3	vitro	vitro	X
ctmj-146	55	4	+	+	CCONJ
ctmj-146	55	5	in	in	ADP
ctmj-146	55	6	vivo	vivo	ADJ
ctmj-146	55	7	investigations	investigation	NOUN
ctmj-146	55	8	with	with	ADP
ctmj-146	55	9	hepatocellular	hepatocellular	NOUN
ctmj-146	55	10	and	and	CCONJ
ctmj-146	55	11	colorectal	colorectal	ADJ
ctmj-146	55	12	cancer	cancer	NOUN
ctmj-146	55	13	cells	cell	NOUN
ctmj-146	55	14	,	,	PUNCT
ctmj-146	55	15	as	as	ADV
ctmj-146	55	16	well	well	ADV
ctmj-146	55	17	as	as	ADP
ctmj-146	55	18	three	three	NUM
ctmj-146	55	19	in	in	ADP
ctmj-146	55	20	vitro	vitro	X
ctmj-146	55	21	investigations	investigation	NOUN
ctmj-146	55	22	with	with	ADP
ctmj-146	55	23	gastric	gastric	ADJ
ctmj-146	55	24	,	,	PUNCT
ctmj-146	55	25	breast	breast	NOUN
ctmj-146	55	26	,	,	PUNCT
ctmj-146	55	27	and	and	CCONJ
ctmj-146	55	28	glioma	glioma	NOUN
ctmj-146	55	29	cell	cell	NOUN
ctmj-146	55	30	lines20,21,23.24,25	lines20,21,23.24,25	PROPN
ctmj-146	55	31	although	although	SCONJ
ctmj-146	55	32	more	more	ADJ
ctmj-146	55	33	research	research	NOUN
ctmj-146	55	34	is	be	AUX
ctmj-146	55	35	needed	need	VERB
ctmj-146	55	36	,	,	PUNCT
ctmj-146	55	37	the	the	DET
ctmj-146	55	38	current	current	ADJ
ctmj-146	55	39	findings	finding	NOUN
ctmj-146	55	40	support	support	VERB
ctmj-146	55	41	the	the	DET
ctmj-146	55	42	idea	idea	NOUN
ctmj-146	55	43	of	of	ADP
ctmj-146	55	44	cvb	cvb	PROPN
ctmj-146	55	45	-	-	PROPN
ctmj-146	55	46	d	d	PROPN
ctmj-146	55	47	as	as	ADP
ctmj-146	55	48	a	a	DET
ctmj-146	55	49	potential	potential	ADJ
ctmj-146	55	50	new	new	ADJ
ctmj-146	55	51	cancer	cancer	NOUN
ctmj-146	55	52	treatment	treatment	NOUN
ctmj-146	55	53	.	.	PUNCT
ctmj-146	56	1	but	but	CCONJ
ctmj-146	56	2	details	detail	NOUN
ctmj-146	56	3	of	of	ADP
ctmj-146	56	4	how	how	SCONJ
ctmj-146	56	5	it	it	PRON
ctmj-146	56	6	works	work	VERB
ctmj-146	56	7	are	be	AUX
ctmj-146	56	8	all	all	ADV
ctmj-146	56	9	over	over	ADP
ctmj-146	56	10	the	the	DET
ctmj-146	56	11	place	place	NOUN
ctmj-146	56	12	.	.	PUNCT
ctmj-146	57	1	specifically	specifically	ADV
ctmj-146	57	2	,	,	PUNCT
ctmj-146	57	3	cvb	cvb	PROPN
ctmj-146	57	4	-	-	PUNCT
ctmj-146	57	5	d	d	PROPN
ctmj-146	57	6	's	's	PART
ctmj-146	57	7	probable	probable	ADJ
ctmj-146	57	8	molecular	molecular	ADJ
ctmj-146	57	9	targets	target	NOUN
ctmj-146	57	10	are	be	AUX
ctmj-146	57	11	still	still	ADV
ctmj-146	57	12	mostly	mostly	ADV
ctmj-146	57	13	unknown	unknown	ADJ
ctmj-146	57	14	(	(	PUNCT
ctmj-146	57	15	see	see	VERB
ctmj-146	57	16	below	below	ADV
ctmj-146	57	17	)	)	PUNCT
ctmj-146	57	18	.	.	PUNCT
ctmj-146	58	1	different	different	ADJ
ctmj-146	58	2	things	thing	NOUN
ctmj-146	58	3	that	that	PRON
ctmj-146	58	4	cvb	cvb	PROPN
ctmj-146	58	5	-	-	PROPN
ctmj-146	58	6	d	d	PROPN
ctmj-146	58	7	does	do	VERB
ctmj-146	58	8	to	to	PART
ctmj-146	58	9	treat	treat	VERB
ctmj-146	58	10	or	or	CCONJ
ctmj-146	58	11	prevent	prevent	VERB
ctmj-146	58	12	many	many	ADJ
ctmj-146	58	13	cardiovascular	cardiovascular	ADJ
ctmj-146	58	14	illnesses	illness	NOUN
ctmj-146	58	15	,	,	PUNCT
ctmj-146	58	16	cvb	cvb	PROPN
ctmj-146	58	17	-	-	PUNCT
ctmj-146	58	18	d	d	PROPN
ctmj-146	58	19	is	be	AUX
ctmj-146	58	20	an	an	DET
ctmj-146	58	21	effective	effective	ADJ
ctmj-146	58	22	medicine	medicine	NOUN
ctmj-146	58	23	.	.	PUNCT
ctmj-146	59	1	cardiomyocytes	cardiomyocyte	NOUN
ctmj-146	59	2	damaged	damage	VERB
ctmj-146	59	3	by	by	ADP
ctmj-146	59	4	oxidation	oxidation	NOUN
ctmj-146	59	5	or	or	CCONJ
ctmj-146	59	6	hypoxia	hypoxia	NOUN
ctmj-146	59	7	are	be	AUX
ctmj-146	59	8	more	more	ADV
ctmj-146	59	9	likely	likely	ADJ
ctmj-146	59	10	to	to	PART
ctmj-146	59	11	survive	survive	VERB
ctmj-146	59	12	after	after	ADP
ctmj-146	59	13	taking	take	VERB
ctmj-146	59	14	this	this	DET
ctmj-146	59	15	medicine.27	medicine.27	NOUN
ctmj-146	59	16	additionally	additionally	ADV
ctmj-146	59	17	,	,	PUNCT
ctmj-146	59	18	it	it	PRON
ctmj-146	59	19	activates	activate	VERB
ctmj-146	59	20	an	an	DET
ctmj-146	59	21	antioxidant	antioxidant	ADJ
ctmj-146	59	22	response	response	NOUN
ctmj-146	59	23	mediated	mediate	VERB
ctmj-146	59	24	by	by	ADP
ctmj-146	59	25	nrf	nrf	PROPN
ctmj-146	59	26	2	2	NUM
ctmj-146	59	27	that	that	PRON
ctmj-146	59	28	protects	protect	VERB
ctmj-146	59	29	against	against	ADP
ctmj-146	59	30	diabetic	diabetic	ADJ
ctmj-146	59	31	cardiomyopathy	cardiomyopathy	ADJ
ctmj-146	59	32	.	.	PUNCT
ctmj-146	60	1	based	base	VERB
ctmj-146	60	2	on	on	ADP
ctmj-146	60	3	a	a	DET
ctmj-146	60	4	molecular	molecular	ADJ
ctmj-146	60	5	modeling	modeling	NOUN
ctmj-146	60	6	investigation	investigation	NOUN
ctmj-146	60	7	,	,	PUNCT
ctmj-146	60	8	it	it	PRON
ctmj-146	60	9	has	have	AUX
ctmj-146	60	10	been	be	AUX
ctmj-146	60	11	suggested	suggest	VERB
ctmj-146	60	12	that	that	SCONJ
ctmj-146	60	13	cvb	cvb	PROPN
ctmj-146	60	14	-	-	PUNCT
ctmj-146	60	15	d	d	PROPN
ctmj-146	60	16	directly	directly	ADV
ctmj-146	60	17	binds	bind	VERB
ctmj-146	60	18	to	to	ADP
ctmj-146	60	19	nrf2	nrf2	PROPN
ctmj-146	60	20	,	,	PUNCT
ctmj-146	60	21	a	a	DET
ctmj-146	60	22	transcription	transcription	NOUN
ctmj-146	60	23	factor	factor	NOUN
ctmj-146	60	24	.	.	PUNCT
ctmj-146	61	1	this	this	PRON
ctmj-146	61	2	might	might	AUX
ctmj-146	61	3	explain	explain	VERB
ctmj-146	61	4	why	why	SCONJ
ctmj-146	61	5	drugs	drug	NOUN
ctmj-146	61	6	can	can	AUX
ctmj-146	61	7	increase	increase	VERB
ctmj-146	61	8	nrf2	nrf2	PROPN
ctmj-146	61	9	's	's	PART
ctmj-146	61	10	nuclear	nuclear	ADJ
ctmj-146	61	11	translocation	translocation	NOUN
ctmj-146	61	12	and	and	CCONJ
ctmj-146	61	13	reduce	reduce	VERB
ctmj-146	61	14	oxidative	oxidative	ADJ
ctmj-146	61	15	stress.28	stress.28	NOUN
ctmj-146	61	16	similarly	similarly	ADV
ctmj-146	61	17	,	,	PUNCT
ctmj-146	61	18	doxorubicin	doxorubicin	PROPN
ctmj-146	61	19	,	,	PUNCT
ctmj-146	61	20	an	an	DET
ctmj-146	61	21	anticancer	anticancer	NOUN
ctmj-146	61	22	medication	medication	NOUN
ctmj-146	61	23	,	,	PUNCT
ctmj-146	61	24	may	may	AUX
ctmj-146	61	25	cause	cause	VERB
ctmj-146	61	26	cardiotoxicity	cardiotoxicity	NOUN
ctmj-146	61	27	;	;	PUNCT
ctmj-146	61	28	however	however	ADV
ctmj-146	61	29	,	,	PUNCT
ctmj-146	61	30	cvb	cvb	PROPN
ctmj-146	61	31	-	-	PUNCT
ctmj-146	61	32	d	d	PROPN
ctmj-146	61	33	can	can	AUX
ctmj-146	61	34	protect	protect	VERB
ctmj-146	61	35	against	against	ADP
ctmj-146	61	36	this	this	PRON
ctmj-146	61	37	.	.	PUNCT
ctmj-146	62	1	in	in	ADP
ctmj-146	62	2	vitro	vitro	X
ctmj-146	62	3	,	,	PUNCT
ctmj-146	62	4	it	it	PRON
ctmj-146	62	5	decreased	decrease	VERB
ctmj-146	62	6	cardiac	cardiac	ADJ
ctmj-146	62	7	oxidative	oxidative	ADJ
ctmj-146	62	8	damages	damage	NOUN
ctmj-146	62	9	and	and	CCONJ
ctmj-146	62	10	mitochondrial	mitochondrial	ADJ
ctmj-146	62	11	biogenesis	biogenesis	NOUN
ctmj-146	62	12	impairment	impairment	NOUN
ctmj-146	62	13	by	by	ADP
ctmj-146	62	14	doxorubicininduced	doxorubicininduce	VERB
ctmj-146	62	15	myocardial	myocardial	ADJ
ctmj-146	62	16	cell	cell	NOUN
ctmj-146	62	17	death.29	death.29	NOUN
ctmj-146	62	18	cvb	cvb	PROPN
ctmj-146	62	19	-	-	PUNCT
ctmj-146	62	20	d	d	PROPN
ctmj-146	62	21	is	be	AUX
ctmj-146	62	22	not	not	PART
ctmj-146	62	23	the	the	DET
ctmj-146	62	24	only	only	ADJ
ctmj-146	62	25	one	one	NUM
ctmj-146	62	26	with	with	ADP
ctmj-146	62	27	this	this	DET
ctmj-146	62	28	quality	quality	NOUN
ctmj-146	62	29	.	.	PUNCT
ctmj-146	63	1	cyclobuxine	cyclobuxine	PROPN
ctmj-146	63	2	and	and	CCONJ
ctmj-146	63	3	buxaustroines	buxaustroine	VERB
ctmj-146	63	4	a	a	PRON
ctmj-146	63	5	-	-	PUNCT
ctmj-146	63	6	n	n	CCONJ
ctmj-146	63	7	,	,	PUNCT
ctmj-146	63	8	two	two	NUM
ctmj-146	63	9	other	other	ADJ
ctmj-146	63	10	alkaloids	alkaloid	NOUN
ctmj-146	63	11	derived	derive	VERB
ctmj-146	63	12	from	from	ADP
ctmj-146	63	13	the	the	DET
ctmj-146	63	14	chinese	chinese	ADJ
ctmj-146	63	15	shrub	shrub	PROPN
ctmj-146	63	16	buxus	buxu	VERB
ctmj-146	63	17	austro	austro	NOUN
ctmj-146	63	18	-	-	PUNCT
ctmj-146	63	19	yunnanensis	yunnanensis	NOUN
ctmj-146	63	20	,	,	PUNCT
ctmj-146	63	21	have	have	AUX
ctmj-146	63	22	shown	show	VERB
ctmj-146	63	23	cardioprotective	cardioprotective	ADJ
ctmj-146	63	24	effects	effect	NOUN
ctmj-146	63	25	(	(	PUNCT
ctmj-146	63	26	fig	fig	NOUN
ctmj-146	63	27	.	.	PUNCT
ctmj-146	64	1	2).30	2).30	NUM
ctmj-146	64	2	other	other	ADJ
ctmj-146	64	3	anticancer	anticancer	NOUN
ctmj-146	64	4	buxus	buxu	VERB
ctmj-146	64	5	natural	natural	ADJ
ctmj-146	64	6	products	product	NOUN
ctmj-146	64	7	in	in	ADP
ctmj-146	64	8	vitro	vitro	X
ctmj-146	64	9	studies	study	NOUN
ctmj-146	64	10	have	have	AUX
ctmj-146	64	11	shown	show	VERB
ctmj-146	64	12	that	that	SCONJ
ctmj-146	64	13	extracts	extract	NOUN
ctmj-146	64	14	from	from	ADP
ctmj-146	64	15	many	many	ADJ
ctmj-146	64	16	buxus	buxus	NOUN
ctmj-146	64	17	plants	plant	NOUN
ctmj-146	64	18	,	,	PUNCT
ctmj-146	64	19	including	include	VERB
ctmj-146	64	20	buxus	buxus	NOUN
ctmj-146	64	21	papillosa	papillosa	NOUN
ctmj-146	64	22	,	,	PUNCT
ctmj-146	64	23	buxus	buxus	NOUN
ctmj-146	64	24	hildebrandtii	hildebrandtii	NOUN
ctmj-146	64	25	,	,	PUNCT
ctmj-146	64	26	and	and	CCONJ
ctmj-146	64	27	buxus	buxus	NOUN
ctmj-146	64	28	sempervirens	semperviren	NOUN
ctmj-146	64	29	,	,	PUNCT
ctmj-146	64	30	have	have	VERB
ctmj-146	64	31	substantial	substantial	ADJ
ctmj-146	64	32	antiproliferative	antiproliferative	ADJ
ctmj-146	64	33	activity	activity	NOUN
ctmj-146	64	34	against	against	ADP
ctmj-146	64	35	various	various	ADJ
ctmj-146	64	36	cancer	cancer	NOUN
ctmj-146	64	37	cells.no	cells.no	PROPN
ctmj-146	64	38	.	.	PROPN
ctmj-146	64	39	31	31	NUM
ctmj-146	64	40	33	33	NUM
ctmj-146	64	41	the	the	DET
ctmj-146	64	42	ability	ability	NOUN
ctmj-146	64	43	of	of	ADP
ctmj-146	64	44	an	an	DET
ctmj-146	64	45	acetonic	acetonic	ADJ
ctmj-146	64	46	b.	b.	PROPN
ctmj-146	64	47	sempervirens	semperviren	NOUN
ctmj-146	64	48	extract	extract	VERB
ctmj-146	64	49	to	to	PART
ctmj-146	64	50	suppress	suppress	VERB
ctmj-146	64	51	the	the	DET
ctmj-146	64	52	growth	growth	NOUN
ctmj-146	64	53	of	of	ADP
ctmj-146	64	54	cancer	cancer	NOUN
ctmj-146	64	55	cells	cell	NOUN
ctmj-146	64	56	and	and	CCONJ
ctmj-146	64	57	to	to	PART
ctmj-146	64	58	induce	induce	VERB
ctmj-146	64	59	apoptosis	apoptosis	NOUN
ctmj-146	64	60	and	and	CCONJ
ctmj-146	64	61	autophagy	autophagy	NOUN
ctmj-146	64	62	in	in	ADP
ctmj-146	64	63	cancer	cancer	NOUN
ctmj-146	64	64	cells	cell	NOUN
ctmj-146	64	65	is	be	AUX
ctmj-146	64	66	particularly	particularly	ADV
ctmj-146	64	67	noteworthy.33	noteworthy.33	ADJ
ctmj-146	64	68	while	while	SCONJ
ctmj-146	64	69	alkaloids	alkaloid	NOUN
ctmj-146	64	70	and	and	CCONJ
ctmj-146	64	71	cyclovirobuxines	cyclovirobuxine	NOUN
ctmj-146	64	72	are	be	AUX
ctmj-146	64	73	present	present	ADJ
ctmj-146	64	74	in	in	ADP
ctmj-146	64	75	these	these	DET
ctmj-146	64	76	extracts	extract	NOUN
ctmj-146	64	77	,	,	PUNCT
ctmj-146	64	78	they	they	PRON
ctmj-146	64	79	are	be	AUX
ctmj-146	64	80	far	far	ADV
ctmj-146	64	81	from	from	ADP
ctmj-146	64	82	the	the	DET
ctmj-146	64	83	only	only	ADJ
ctmj-146	64	84	natural	natural	ADJ
ctmj-146	64	85	compounds	compound	NOUN
ctmj-146	64	86	they	they	PRON
ctmj-146	64	87	contain	contain	VERB
ctmj-146	64	88	.	.	PUNCT
ctmj-146	65	1	more	more	ADJ
ctmj-146	65	2	than	than	ADP
ctmj-146	65	3	250	250	NUM
ctmj-146	65	4	members	member	NOUN
ctmj-146	65	5	make	make	VERB
ctmj-146	65	6	up	up	ADP
ctmj-146	65	7	the	the	DET
ctmj-146	65	8	enormous	enormous	ADJ
ctmj-146	65	9	and	and	CCONJ
ctmj-146	65	10	diverse	diverse	ADJ
ctmj-146	65	11	buxus	buxus	NOUN
ctmj-146	65	12	alkaloid	alkaloid	PROPN
ctmj-146	65	13	family	family	NOUN
ctmj-146	65	14	to	to	PART
ctmj-146	65	15	which	which	PRON
ctmj-146	65	16	cvb	cvb	PROPN
ctmj-146	65	17	-	-	PUNCT
ctmj-146	65	18	d	d	NOUN
ctmj-146	65	19	belongs	belong	VERB
ctmj-146	65	20	;	;	PUNCT
ctmj-146	65	21	these	these	DET
ctmj-146	65	22	members	member	NOUN
ctmj-146	65	23	all	all	PRON
ctmj-146	65	24	have	have	VERB
ctmj-146	65	25	a	a	DET
ctmj-146	65	26	core	core	NOUN
ctmj-146	65	27	structure	structure	NOUN
ctmj-146	65	28	that	that	PRON
ctmj-146	65	29	is	be	AUX
ctmj-146	65	30	triterpenoid	triterpenoid	NOUN
ctmj-146	65	31	-	-	PUNCT
ctmj-146	65	32	steroidal	steroidal	NOUN
ctmj-146	65	33	pregnane	pregnane	ADJ
ctmj-146	65	34	tetracyclic	tetracyclic	NOUN
ctmj-146	65	35	(	(	PUNCT
ctmj-146	65	36	fig	fig	NOUN
ctmj-146	65	37	.	.	PUNCT
ctmj-146	66	1	2).34	2).34	NUM
ctmj-146	67	1	the	the	DET
ctmj-146	67	2	members	member	NOUN
ctmj-146	67	3	of	of	ADP
ctmj-146	67	4	this	this	DET
ctmj-146	67	5	family	family	NOUN
ctmj-146	67	6	may	may	AUX
ctmj-146	67	7	be	be	AUX
ctmj-146	67	8	categorized	categorize	VERB
ctmj-146	67	9	into	into	ADP
ctmj-146	67	10	two	two	NUM
ctmj-146	67	11	groups	group	NOUN
ctmj-146	67	12	based	base	VERB
ctmj-146	67	13	on	on	ADP
ctmj-146	67	14	the	the	DET
ctmj-146	67	15	number	number	NOUN
ctmj-146	67	16	of	of	ADP
ctmj-146	67	17	b	b	NOUN
ctmj-146	67	18	rings	ring	NOUN
ctmj-146	67	19	they	they	PRON
ctmj-146	67	20	contain	contain	VERB
ctmj-146	67	21	:	:	PUNCT
ctmj-146	67	22	those	those	PRON
ctmj-146	67	23	with	with	ADP
ctmj-146	67	24	a	a	DET
ctmj-146	67	25	7	7	NUM
ctmj-146	67	26	-	-	PUNCT
ctmj-146	67	27	membered	membere	VERB
ctmj-146	67	28	ring	ring	NOUN
ctmj-146	67	29	and	and	CCONJ
ctmj-146	67	30	those	those	PRON
ctmj-146	67	31	with	with	ADP
ctmj-146	67	32	a	a	DET
ctmj-146	67	33	6	6	NUM
ctmj-146	67	34	-	-	PUNCT
ctmj-146	67	35	membered	membere	VERB
ctmj-146	67	36	ring	ring	NOUN
ctmj-146	67	37	.	.	PUNCT
ctmj-146	68	1	the	the	DET
ctmj-146	68	2	first	first	ADJ
ctmj-146	68	3	group	group	NOUN
ctmj-146	68	4	consists	consist	VERB
ctmj-146	68	5	of	of	ADP
ctmj-146	68	6	derivatives	derivative	NOUN
ctmj-146	68	7	of	of	ADP
ctmj-146	68	8	the	the	DET
ctmj-146	68	9	9(10e19)-abeo-4,4,14a	9(10e19)-abeo-4,4,14a	NOUN
ctmj-146	68	10	-	-	PUNCT
ctmj-146	68	11	trimethyl-5a	trimethyl-5a	NOUN
ctmj-146	68	12	-	-	PUNCT
ctmj-146	68	13	pregnane	pregnane	NOUN
ctmj-146	68	14	system.similar	system.similar	NOUN
ctmj-146	68	15	to	to	ADP
ctmj-146	68	16	the	the	DET
ctmj-146	68	17	other	other	ADJ
ctmj-146	68	18	natural	natural	ADJ
ctmj-146	68	19	products	product	NOUN
ctmj-146	68	20	shown	show	VERB
ctmj-146	68	21	in	in	ADP
ctmj-146	68	22	figure	figure	NOUN
ctmj-146	68	23	2	2	NUM
ctmj-146	68	24	,	,	PUNCT
ctmj-146	68	25	including	include	VERB
ctmj-146	68	26	cyclovirobuxeine	cyclovirobuxeine	NOUN
ctmj-146	68	27	a	a	PRON
ctmj-146	68	28	,	,	PUNCT
ctmj-146	68	29	buxandrine	buxandrine	NOUN
ctmj-146	68	30	,	,	PUNCT
ctmj-146	68	31	and	and	CCONJ
ctmj-146	68	32	e	e	NOUN
ctmj-146	68	33	-	-	NOUN
ctmj-146	68	34	buxenone	buxenone	ADJ
ctmj-146	68	35	,	,	PUNCT
ctmj-146	68	36	cyclovirobuxines	cyclovirobuxine	VERB
ctmj-146	68	37	a	a	DET
ctmj-146	68	38	–	–	PUNCT
ctmj-146	68	39	d	d	NOUN
ctmj-146	68	40	belong	belong	VERB
ctmj-146	68	41	to	to	ADP
ctmj-146	68	42	the	the	DET
ctmj-146	68	43	second	second	ADJ
ctmj-146	68	44	category	category	NOUN
ctmj-146	68	45	.	.	PUNCT
ctmj-146	69	1	buxmicrophylline	buxmicrophylline	PROPN
ctmj-146	69	2	b	b	PROPN
ctmj-146	69	3	and	and	CCONJ
ctmj-146	69	4	n	n	CCONJ
ctmj-146	69	5	-	-	PUNCT
ctmj-146	69	6	acetyldihydrocyclomicrophylline	acetyldihydrocyclomicrophylline	NOUN
ctmj-146	69	7	f	f	NOUN
ctmj-146	69	8	,	,	PUNCT
ctmj-146	69	9	both	both	PRON
ctmj-146	69	10	derived	derive	VERB
ctmj-146	69	11	from	from	ADP
ctmj-146	69	12	b.	b.	PROPN
ctmj-146	69	13	microphylla	microphylla	PROPN
ctmj-146	69	14	,	,	PUNCT
ctmj-146	69	15	have	have	AUX
ctmj-146	69	16	shown	show	VERB
ctmj-146	69	17	cytotoxic	cytotoxic	ADJ
ctmj-146	69	18	effects	effect	NOUN
ctmj-146	69	19	on	on	ADP
ctmj-146	69	20	cancer	cancer	NOUN
ctmj-146	69	21	cells	cell	NOUN
ctmj-146	69	22	,	,	PUNCT
ctmj-146	69	23	such	such	ADJ
ctmj-146	69	24	as	as	ADP
ctmj-146	69	25	hl60	hl60	PROPN
ctmj-146	69	26	leukemia	leukemia	NOUN
ctmj-146	69	27	cells	cell	NOUN
ctmj-146	69	28	and	and	CCONJ
ctmj-146	69	29	human	human	ADJ
ctmj-146	69	30	tumor	tumor	NOUN
ctmj-146	69	31	hepg2	hepg2	VERB
ctmj-146	69	32	cells	cell	NOUN
ctmj-146	69	33	(	(	PUNCT
ctmj-146	69	34	with	with	ADP
ctmj-146	69	35	sub	sub	ADJ
ctmj-146	69	36	-	-	ADJ
ctmj-146	69	37	micromolar	micromolar	ADJ
ctmj-146	69	38	activity	activity	NOUN
ctmj-146	69	39	against	against	ADP
ctmj-146	69	40	both	both	DET
ctmj-146	69	41	types	type	NOUN
ctmj-146	69	42	of	of	ADP
ctmj-146	69	43	cells).5	cells).5	PROPN
ctmj-146	69	44	not	not	PART
ctmj-146	69	45	all	all	DET
ctmj-146	69	46	buxus	buxus	NOUN
ctmj-146	69	47	alkaloids	alkaloid	NOUN
ctmj-146	69	48	are	be	AUX
ctmj-146	69	49	cytotoxic	cytotoxic	ADJ
ctmj-146	69	50	;	;	PUNCT
ctmj-146	69	51	nevertheless	nevertheless	ADV
ctmj-146	69	52	,	,	PUNCT
ctmj-146	69	53	those	those	PRON
ctmj-146	69	54	that	that	PRON
ctmj-146	69	55	are	be	AUX
ctmj-146	69	56	either	either	CCONJ
ctmj-146	69	57	mildly	mildly	ADV
ctmj-146	69	58	or	or	CCONJ
ctmj-146	69	59	additional	additional	ADJ
ctmj-146	69	60	beneficial	beneficial	ADJ
ctmj-146	69	61	characteristics	characteristic	NOUN
ctmj-146	69	62	may	may	AUX
ctmj-146	69	63	be	be	AUX
ctmj-146	69	64	shown	show	VERB
ctmj-146	69	65	by	by	ADP
ctmj-146	69	66	non	non	ADJ
ctmj-146	69	67	-	-	ADJ
ctmj-146	69	68	cytotoxic	cytotoxic	ADJ
ctmj-146	69	69	chemicals	chemical	NOUN
ctmj-146	69	70	.	.	PUNCT
ctmj-146	70	1	one	one	NUM
ctmj-146	70	2	such	such	ADJ
ctmj-146	70	3	cycloartane	cycloartane	PROPN
ctmj-146	70	4	alkaloid	alkaloid	PROPN
ctmj-146	70	5	is	be	AUX
ctmj-146	70	6	otigloylcyclovirobuxeine	otigloylcyclovirobuxeine	NOUN
ctmj-146	70	7	-	-	PUNCT
ctmj-146	70	8	b	b	NOUN
ctmj-146	70	9	,	,	PUNCT
ctmj-146	70	10	which	which	PRON
ctmj-146	70	11	has	have	VERB
ctmj-146	70	12	a	a	DET
ctmj-146	70	13	strong	strong	ADJ
ctmj-146	70	14	anti	anti	ADJ
ctmj-146	70	15	-	-	ADJ
ctmj-146	70	16	parasitic	parasitic	ADJ
ctmj-146	70	17	action	action	NOUN
ctmj-146	70	18	against	against	ADP
ctmj-146	70	19	the	the	DET
ctmj-146	70	20	malaria	malaria	NOUN
ctmj-146	70	21	parasite	parasite	NOUN
ctmj-146	70	22	plasmodium	plasmodium	NOUN
ctmj-146	70	23	falciparum	falciparum	NOUN
ctmj-146	70	24	but	but	CCONJ
ctmj-146	70	25	very	very	ADV
ctmj-146	70	26	mild	mild	ADJ
ctmj-146	70	27	cytotoxic	cytotoxic	ADJ
ctmj-146	70	28	effects	effect	NOUN
ctmj-146	70	29	on	on	ADP
ctmj-146	70	30	l6	l6	ADJ
ctmj-146	70	31	rat	rat	NOUN
ctmj-146	70	32	cells.36,37	cells.36,37	NOUN
ctmj-146	70	33	it	it	PRON
ctmj-146	70	34	has	have	AUX
ctmj-146	70	35	also	also	ADV
ctmj-146	70	36	been	be	AUX
ctmj-146	70	37	shown	show	VERB
ctmj-146	70	38	to	to	PART
ctmj-146	70	39	have	have	VERB
ctmj-146	70	40	anti	anti	ADJ
ctmj-146	70	41	-	-	ADJ
ctmj-146	70	42	leishmanial	leishmanial	ADJ
ctmj-146	70	43	and	and	CCONJ
ctmj-146	70	44	anti	anti	ADJ
ctmj-146	70	45	-	-	ADJ
ctmj-146	70	46	fungal	fungal	ADJ
ctmj-146	70	47	bioactivities.38	bioactivities.38	NOUN
ctmj-146	70	48	a	a	DET
ctmj-146	70	49	number	number	NOUN
ctmj-146	70	50	of	of	ADP
ctmj-146	70	51	buxus	buxus	NOUN
ctmj-146	70	52	alkaloids	alkaloid	NOUN
ctmj-146	70	53	,	,	PUNCT
ctmj-146	70	54	including	include	VERB
ctmj-146	70	55	buxamine	buxamine	NOUN
ctmj-146	70	56	c	c	NOUN
ctmj-146	70	57	,	,	PUNCT
ctmj-146	70	58	have	have	AUX
ctmj-146	70	59	been	be	AUX
ctmj-146	70	60	shown	show	VERB
ctmj-146	70	61	to	to	PART
ctmj-146	70	62	inhibit	inhibit	VERB
ctmj-146	70	63	acetyl	acetyl	NOUN
ctmj-146	70	64	-	-	PUNCT
ctmj-146	70	65	cholinesterase	cholinesterase	NOUN
ctmj-146	70	66	(	(	PUNCT
ctmj-146	70	67	ache	ache	PROPN
ctmj-146	70	68	)	)	PUNCT
ctmj-146	70	69	,	,	PUNCT
ctmj-146	70	70	an	an	DET
ctmj-146	70	71	enzyme	enzyme	NOUN
ctmj-146	70	72	critical	critical	ADJ
ctmj-146	70	73	to	to	ADP
ctmj-146	70	74	the	the	DET
ctmj-146	70	75	breakdown	breakdown	NOUN
ctmj-146	70	76	of	of	ADP
ctmj-146	70	77	the	the	DET
ctmj-146	70	78	neurotransmitter	neurotransmitter	NOUN
ctmj-146	70	79	acetylcholine	acetylcholine	NOUN
ctmj-146	70	80	.	.	PUNCT
ctmj-146	71	1	molecular	molecular	ADJ
ctmj-146	71	2	modeling	modeling	NOUN
ctmj-146	71	3	has	have	AUX
ctmj-146	71	4	led	lead	VERB
ctmj-146	71	5	to	to	ADP
ctmj-146	71	6	the	the	DET
ctmj-146	71	7	hypothesis	hypothesis	NOUN
ctmj-146	71	8	that	that	PRON
ctmj-146	71	9	the	the	DET
ctmj-146	71	10	drug	drug	NOUN
ctmj-146	71	11	interacts	interact	VERB
ctmj-146	71	12	directly	directly	ADV
ctmj-146	71	13	with	with	ADP
ctmj-146	71	14	this	this	DET
ctmj-146	71	15	enzyme.39	enzyme.39	NOUN
ctmj-146	71	16	however	however	ADV
ctmj-146	71	17	,	,	PUNCT
ctmj-146	71	18	in	in	ADP
ctmj-146	71	19	several	several	ADJ
ctmj-146	71	20	instances	instance	NOUN
ctmj-146	71	21	,	,	PUNCT
ctmj-146	71	22	the	the	DET
ctmj-146	71	23	level	level	NOUN
ctmj-146	71	24	of	of	ADP
ctmj-146	71	25	40ache	40ache	NOUN
ctmj-146	71	26	inhibition	inhibition	NOUN
ctmj-146	71	27	is	be	AUX
ctmj-146	71	28	low	low	ADJ
ctmj-146	71	29	;	;	PUNCT
ctmj-146	71	30	for	for	ADP
ctmj-146	71	31	example	example	NOUN
ctmj-146	71	32	,	,	PUNCT
ctmj-146	71	33	buxidine	buxidine	NOUN
ctmj-146	71	34	and	and	CCONJ
ctmj-146	71	35	buxandrine	buxandrine	NOUN
ctmj-146	71	36	have	have	VERB
ctmj-146	71	37	ic50	ic50	PROPN
ctmj-146	71	38	values	value	NOUN
ctmj-146	71	39	more	more	ADJ
ctmj-146	71	40	than	than	ADP
ctmj-146	71	41	100	100	NUM
ctmj-146	71	42	mm.40	mm.40	NOUN
ctmj-146	71	43	although	although	SCONJ
ctmj-146	71	44	buxmicrophylline	buxmicrophylline	PROPN
ctmj-146	71	45	c	c	PROPN
ctmj-146	71	46	and	and	CCONJ
ctmj-146	71	47	buxbodine	buxbodine	PROPN
ctmj-146	71	48	b	b	PROPN
ctmj-146	71	49	,	,	PUNCT
ctmj-146	71	50	both	both	PRON
ctmj-146	71	51	derived	derive	VERB
ctmj-146	71	52	from	from	ADP
ctmj-146	71	53	buxus	buxus	ADJ
ctmj-146	71	54	macowanii	macowanii	NOUN
ctmj-146	71	55	,	,	PUNCT
ctmj-146	71	56	are	be	AUX
ctmj-146	71	57	more	more	ADV
ctmj-146	71	58	effective	effective	ADJ
ctmj-146	71	59	ache	ache	NOUN
ctmj-146	71	60	inhibitors	inhibitor	NOUN
ctmj-146	71	61	,	,	PUNCT
ctmj-146	71	62	their	their	PRON
ctmj-146	71	63	ic50	ic50	PROPN
ctmj-146	71	64	values	value	NOUN
ctmj-146	71	65	remain	remain	VERB
ctmj-146	71	66	quite	quite	ADV
ctmj-146	71	67	high	high	ADJ
ctmj-146	71	68	,	,	PUNCT
ctmj-146	71	69	exceeding	exceed	VERB
ctmj-146	71	70	10	10	NUM
ctmj-146	71	71	mm.41	mm.41	NOUN
ctmj-146	71	72	two	two	NUM
ctmj-146	71	73	chemicals	chemical	NOUN
ctmj-146	71	74	with	with	ADP
ctmj-146	71	75	anticancer	anticancer	NOUN
ctmj-146	71	76	properties	property	NOUN
ctmj-146	71	77	are	be	AUX
ctmj-146	71	78	isolated	isolate	VERB
ctmj-146	71	79	from	from	ADP
ctmj-146	71	80	the	the	DET
ctmj-146	71	81	compound	compound	NOUN
ctmj-146	71	82	family	family	NOUN
ctmj-146	71	83	.	.	PUNCT
ctmj-146	72	1	one	one	NUM
ctmj-146	72	2	of	of	ADP
ctmj-146	72	3	them	they	PRON
ctmj-146	72	4	is	be	AUX
ctmj-146	72	5	kba01	kba01	NOUN
ctmj-146	72	6	,	,	PUNCT
ctmj-146	72	7	a	a	DET
ctmj-146	72	8	triterpenoid	triterpenoid	NOUN
ctmj-146	72	9	alkaloid	alkaloid	NOUN
ctmj-146	72	10	derived	derive	VERB
ctmj-146	72	11	from	from	ADP
ctmj-146	72	12	b.	b.	PROPN
ctmj-146	72	13	microphylla	microphylla	PROPN
ctmj-146	72	14	that	that	PRON
ctmj-146	72	15	has	have	AUX
ctmj-146	72	16	shown	show	VERB
ctmj-146	72	17	promising	promising	ADJ
ctmj-146	72	18	antiproliferative	antiproliferative	ADJ
ctmj-146	72	19	effects	effect	NOUN
ctmj-146	72	20	against	against	ADP
ctmj-146	72	21	several	several	ADJ
ctmj-146	72	22	cancer	cancer	NOUN
ctmj-146	72	23	cell	cell	NOUN
ctmj-146	72	24	lines	line	NOUN
ctmj-146	72	25	.	.	PUNCT
ctmj-146	73	1	it	it	PRON
ctmj-146	73	2	was	be	AUX
ctmj-146	73	3	much	much	ADV
ctmj-146	73	4	more	more	ADV
ctmj-146	73	5	effective	effective	ADJ
ctmj-146	73	6	than	than	ADP
ctmj-146	73	7	other	other	ADJ
ctmj-146	73	8	cancer	cancer	NOUN
ctmj-146	73	9	cell	cell	NOUN
ctmj-146	73	10	lines	line	NOUN
ctmj-146	73	11	against	against	ADP
ctmj-146	73	12	the	the	DET
ctmj-146	73	13	highly	highly	ADV
ctmj-146	73	14	sensitive	sensitive	ADJ
ctmj-146	73	15	ht29	ht29	PROPN
ctmj-146	73	16	colon	colon	NOUN
ctmj-146	73	17	cancer	cancer	NOUN
ctmj-146	73	18	cells	cell	NOUN
ctmj-146	73	19	(	(	PUNCT
ctmj-146	73	20	crc	crc	NOUN
ctmj-146	73	21	;	;	PUNCT
ctmj-146	73	22	ic50	ic50	PROPN
ctmj-146	73	23	=	=	PROPN
ctmj-146	73	24	5	5	NUM
ctmj-146	73	25	mm).the	mm).the	NOUN
ctmj-146	73	26	p53	p53	NOUN
ctmj-146	73	27	protein	protein	NOUN
ctmj-146	73	28	has	have	VERB
ctmj-146	73	29	an	an	DET
ctmj-146	73	30	oncogenic	oncogenic	ADJ
ctmj-146	73	31	mutation	mutation	NOUN
ctmj-146	73	32	(	(	PUNCT
ctmj-146	73	33	r273h	r273h	PROPN
ctmj-146	73	34	mutation	mutation	NOUN
ctmj-146	73	35	)	)	PUNCT
ctmj-146	73	36	in	in	ADP
ctmj-146	73	37	42	42	NUM
ctmj-146	73	38	ht29	ht29	PROPN
ctmj-146	73	39	cells	cell	NOUN
ctmj-146	73	40	.	.	PUNCT
ctmj-146	74	1	similar	similar	ADJ
ctmj-146	74	2	to	to	ADP
ctmj-146	74	3	cvb	cvb	PROPN
ctmj-146	74	4	-	-	PUNCT
ctmj-146	74	5	d	d	PROPN
ctmj-146	74	6	in	in	ADP
ctmj-146	74	7	structure	structure	NOUN
ctmj-146	74	8	(	(	PUNCT
ctmj-146	74	9	fig	fig	NOUN
ctmj-146	74	10	.	.	PUNCT
ctmj-146	75	1	2	2	NUM
ctmj-146	75	2	)	)	PUNCT
ctmj-146	75	3	,	,	PUNCT
ctmj-146	75	4	kba01	kba01	NOUN
ctmj-146	75	5	was	be	AUX
ctmj-146	75	6	discovered	discover	VERB
ctmj-146	75	7	to	to	PART
ctmj-146	75	8	engage	engage	VERB
ctmj-146	75	9	in	in	ADP
ctmj-146	75	10	a	a	DET
ctmj-146	75	11	chaperonemediated	chaperonemediate	VERB
ctmj-146	75	12	cascade	cascade	NOUN
ctmj-146	75	13	that	that	PRON
ctmj-146	75	14	ultimately	ultimately	ADV
ctmj-146	75	15	leads	lead	VERB
ctmj-146	75	16	to	to	ADP
ctmj-146	75	17	the	the	DET
ctmj-146	75	18	death	death	NOUN
ctmj-146	75	19	of	of	ADP
ctmj-146	75	20	tumor	tumor	NOUN
ctmj-146	75	21	suppressor	suppressor	NOUN
ctmj-146	75	22	protein	protein	NOUN
ctmj-146	75	23	p53	p53	NOUN
ctmj-146	75	24	.	.	PUNCT
ctmj-146	76	1	table	table	NOUN
ctmj-146	76	2	1	1	NUM
ctmj-146	76	3	anticancer	anticancer	NOUN
ctmj-146	76	4	activities	activity	NOUN
ctmj-146	76	5	of	of	ADP
ctmj-146	76	6	cyclovirobuxine	cyclovirobuxine	NOUN
ctmj-146	76	7	d	d	NOUN
ctmj-146	76	8	in	in	ADP
ctmj-146	76	9	different	different	ADJ
ctmj-146	76	10	models	model	NOUN
ctmj-146	76	11	.	.	PUNCT
ctmj-146	77	1	cancer	cancer	NOUN
ctmj-146	77	2	models	model	NOUN
ctmj-146	78	1	[	[	X
ctmj-146	79	1	cell	cell	NOUN
ctmj-146	79	2	lines	line	NOUN
ctmj-146	79	3	]	]	PUNCT
ctmj-146	79	4	cyclovirobuxine	cyclovirobuxine	NOUN
ctmj-146	79	5	d	d	NOUN
ctmj-146	79	6	activities	activity	NOUN
ctmj-146	79	7	references	reference	VERB
ctmj-146	79	8	breast	breast	NOUN
ctmj-146	79	9	cancer	cancer	NOUN
ctmj-146	80	1	[	[	X
ctmj-146	80	2	mcf7	mcf7	NOUN
ctmj-146	80	3	]	]	PUNCT
ctmj-146	80	4	inhibition	inhibition	NOUN
ctmj-146	80	5	of	of	ADP
ctmj-146	80	6	cell	cell	NOUN
ctmj-146	80	7	proliferation	proliferation	NOUN
ctmj-146	80	8	20	20	NUM
ctmj-146	80	9	inhibition	inhibition	NOUN
ctmj-146	80	10	of	of	ADP
ctmj-146	80	11	akt	akt	PROPN
ctmj-146	80	12	/	/	SYM
ctmj-146	80	13	mtor	mtor	PROPN
ctmj-146	80	14	axis	axis	ADJ
ctmj-146	80	15	induction	induction	NOUN
ctmj-146	80	16	of	of	ADP
ctmj-146	80	17	autophagy	autophagy	ADJ
ctmj-146	80	18	gastric	gastric	ADJ
ctmj-146	80	19	cancer	cancer	NOUN
ctmj-146	80	20	[	[	X
ctmj-146	80	21	mgc-803	mgc-803	NOUN
ctmj-146	80	22	,	,	PUNCT
ctmj-146	80	23	mkn2	mkn2	NOUN
ctmj-146	80	24	]	]	PUNCT
ctmj-146	80	25	inhibition	inhibition	NOUN
ctmj-146	80	26	of	of	ADP
ctmj-146	80	27	cell	cell	NOUN
ctmj-146	80	28	proliferation	proliferation	NOUN
ctmj-146	80	29	and	and	CCONJ
ctmj-146	80	30	colony	colony	NOUN
ctmj-146	80	31	formation	formation	NOUN
ctmj-146	80	32	21	21	NUM
ctmj-146	80	33	blockade	blockade	NOUN
ctmj-146	80	34	of	of	ADP
ctmj-146	80	35	the	the	DET
ctmj-146	80	36	jak	jak	PROPN
ctmj-146	80	37	-	-	PUNCT
ctmj-146	80	38	stat	stat	PROPN
ctmj-146	80	39	pathway	pathway	NOUN
ctmj-146	80	40	cell	cell	NOUN
ctmj-146	80	41	cycle	cycle	NOUN
ctmj-146	80	42	arrest	arrest	NOUN
ctmj-146	80	43	and	and	CCONJ
ctmj-146	80	44	induction	induction	NOUN
ctmj-146	80	45	of	of	ADP
ctmj-146	80	46	apoptosis	apoptosis	NOUN
ctmj-146	80	47	glioblastoma	glioblastoma	NOUN
ctmj-146	80	48	[	[	X
ctmj-146	80	49	t98	t98	NOUN
ctmj-146	80	50	g	g	NOUN
ctmj-146	80	51	,	,	PUNCT
ctmj-146	80	52	hs683	hs683	PROPN
ctmj-146	80	53	]	]	PUNCT
ctmj-146	80	54	inhibition	inhibition	NOUN
ctmj-146	80	55	of	of	ADP
ctmj-146	80	56	cell	cell	NOUN
ctmj-146	80	57	proliferation	proliferation	NOUN
ctmj-146	80	58	23	23	NUM
ctmj-146	80	59	cell	cell	NOUN
ctmj-146	80	60	cycle	cycle	NOUN
ctmj-146	80	61	block	block	NOUN
ctmj-146	80	62	and	and	CCONJ
ctmj-146	80	63	induction	induction	NOUN
ctmj-146	80	64	of	of	ADP
ctmj-146	80	65	apoptosis	apoptosis	NOUN
ctmj-146	80	66	hepatocellular	hepatocellular	ADJ
ctmj-146	80	67	carcinoma	carcinoma	NOUN
ctmj-146	80	68	[	[	X
ctmj-146	80	69	hepg2	hepg2	ADV
ctmj-146	80	70	,	,	PUNCT
ctmj-146	80	71	hcclm3	hcclm3	NOUN
ctmj-146	80	72	]	]	PUNCT
ctmj-146	80	73	inhibition	inhibition	NOUN
ctmj-146	80	74	of	of	ADP
ctmj-146	80	75	cell	cell	NOUN
ctmj-146	80	76	proliferation	proliferation	NOUN
ctmj-146	80	77	and	and	CCONJ
ctmj-146	80	78	colony	colony	NOUN
ctmj-146	80	79	formation	formation	NOUN
ctmj-146	80	80	24	24	NUM
ctmj-146	80	81	inhibition	inhibition	NOUN
ctmj-146	80	82	of	of	ADP
ctmj-146	80	83	the	the	DET
ctmj-146	80	84	egfr	egfr	PROPN
ctmj-146	80	85	/	/	SYM
ctmj-146	80	86	akt	akt	PROPN
ctmj-146	80	87	/	/	SYM
ctmj-146	80	88	erk1/2	erk1/2	PROPN
ctmj-146	80	89	signaling	signal	VERB
ctmj-146	80	90	pathway	pathway	NOUN
ctmj-146	80	91	cell	cell	NOUN
ctmj-146	80	92	cycle	cycle	NOUN
ctmj-146	80	93	arrest	arrest	NOUN
ctmj-146	80	94	and	and	CCONJ
ctmj-146	80	95	induction	induction	NOUN
ctmj-146	80	96	of	of	ADP
ctmj-146	80	97	apoptosis	apoptosis	NOUN
ctmj-146	80	98	reduction	reduction	NOUN
ctmj-146	80	99	of	of	ADP
ctmj-146	80	100	tumor	tumor	NOUN
ctmj-146	80	101	in	in	ADP
ctmj-146	80	102	vivo	vivo	ADJ
ctmj-146	80	103	colorectal	colorectal	ADJ
ctmj-146	80	104	cancer	cancer	NOUN
ctmj-146	80	105	[	[	X
ctmj-146	80	106	dld-1	dld-1	SYM
ctmj-146	80	107	,	,	PUNCT
ctmj-146	80	108	lovo	lovo	PROPN
ctmj-146	80	109	]	]	PUNCT
ctmj-146	80	110	inhibition	inhibition	NOUN
ctmj-146	80	111	of	of	ADP
ctmj-146	80	112	cell	cell	NOUN
ctmj-146	80	113	proliferation	proliferation	NOUN
ctmj-146	80	114	and	and	CCONJ
ctmj-146	80	115	colony	colony	NOUN
ctmj-146	80	116	formation	formation	NOUN
ctmj-146	80	117	25	25	NUM
ctmj-146	80	118	regulation	regulation	NOUN
ctmj-146	80	119	of	of	ADP
ctmj-146	80	120	the	the	DET
ctmj-146	80	121	epithelial	epithelial	ADJ
ctmj-146	80	122	-	-	PUNCT
ctmj-146	80	123	mesenchymal	mesenchymal	NOUN
ctmj-146	80	124	transition	transition	NOUN
ctmj-146	80	125	reduction	reduction	NOUN
ctmj-146	80	126	of	of	ADP
ctmj-146	80	127	cancer	cancer	NOUN
ctmj-146	80	128	cell	cell	NOUN
ctmj-146	80	129	mobility	mobility	NOUN
ctmj-146	80	130	(	(	PUNCT
ctmj-146	80	131	with	with	ADP
ctmj-146	80	132	reduced	reduced	ADJ
ctmj-146	80	133	expression	expression	NOUN
ctmj-146	80	134	of	of	ADP
ctmj-146	80	135	cthrc1	cthrc1	NOUN
ctmj-146	80	136	)	)	PUNCT
ctmj-146	80	137	induction	induction	NOUN
ctmj-146	80	138	of	of	ADP
ctmj-146	80	139	apoptosis	apoptosis	NOUN
ctmj-146	80	140	in	in	ADP
ctmj-146	80	141	vitro	vitro	X
ctmj-146	80	142	and	and	CCONJ
ctmj-146	80	143	in	in	ADP
ctmj-146	80	144	vivo	vivo	ADJ
ctmj-146	80	145	inhibition	inhibition	NOUN
ctmj-146	80	146	of	of	ADP
ctmj-146	80	147	tumor	tumor	NOUN
ctmj-146	80	148	growth	growth	NOUN
ctmj-146	80	149	in	in	ADP
ctmj-146	80	150	vivo	vivo	ADJ
ctmj-146	80	151	fig	fig	NOUN
ctmj-146	80	152	.	.	PUNCT
ctmj-146	81	1	2	2	X
ctmj-146	81	2	.	.	X
ctmj-146	81	3	structures	structure	NOUN
ctmj-146	81	4	of	of	ADP
ctmj-146	81	5	several	several	ADJ
ctmj-146	81	6	buxus	buxus	NOUN
ctmj-146	81	7	alkaloids	alkaloid	NOUN
ctmj-146	81	8	and	and	CCONJ
ctmj-146	81	9	other	other	ADJ
ctmj-146	81	10	natural	natural	ADJ
ctmj-146	81	11	products	product	NOUN
ctmj-146	81	12	cited	cite	VERB
ctmj-146	81	13	in	in	ADP
ctmj-146	81	14	this	this	DET
ctmj-146	81	15	review	review	NOUN
ctmj-146	81	16	.	.	PUNCT
ctmj-146	82	1	drug	drug	NOUN
ctmj-146	82	2	-	-	PUNCT
ctmj-146	82	3	induced	induce	VERB
ctmj-146	82	4	degradation	degradation	NOUN
ctmj-146	82	5	of	of	ADP
ctmj-146	82	6	the	the	DET
ctmj-146	82	7	mutant	mutant	ADJ
ctmj-146	82	8	p53	p53	NOUN
ctmj-146	82	9	protein	protein	NOUN
ctmj-146	82	10	was	be	AUX
ctmj-146	82	11	not	not	PART
ctmj-146	82	12	seen	see	VERB
ctmj-146	82	13	,	,	PUNCT
ctmj-146	82	14	despite	despite	SCONJ
ctmj-146	82	15	the	the	DET
ctmj-146	82	16	aided	aid	VERB
ctmj-146	82	17	mechanism	mechanism	NOUN
ctmj-146	82	18	.	.	PUNCT
ctmj-146	83	1	an	an	DET
ctmj-146	83	2	attractive	attractive	ADJ
ctmj-146	83	3	anticancer	anticancer	NOUN
ctmj-146	83	4	strategy	strategy	NOUN
ctmj-146	83	5	that	that	PRON
ctmj-146	83	6	works	work	VERB
ctmj-146	83	7	in	in	ADP
ctmj-146	83	8	tandem	tandem	NOUN
ctmj-146	83	9	with	with	ADP
ctmj-146	83	10	existing	exist	VERB
ctmj-146	83	11	medications	medication	NOUN
ctmj-146	83	12	is	be	AUX
ctmj-146	83	13	to	to	PART
ctmj-146	83	14	target	target	VERB
ctmj-146	83	15	the	the	DET
ctmj-146	83	16	proteasomal	proteasomal	ADJ
ctmj-146	83	17	degradation	degradation	NOUN
ctmj-146	83	18	of	of	ADP
ctmj-146	83	19	the	the	DET
ctmj-146	83	20	tumor	tumor	NOUN
ctmj-146	83	21	suppressor	suppressor	NOUN
ctmj-146	83	22	protein	protein	NOUN
ctmj-146	83	23	p53	p53	NOUN
ctmj-146	83	24	.	.	PUNCT
ctmj-146	84	1	when	when	SCONJ
ctmj-146	84	2	combined	combine	VERB
ctmj-146	84	3	with	with	ADP
ctmj-146	84	4	anticancer	anticancer	NOUN
ctmj-146	84	5	drugs	drug	NOUN
ctmj-146	84	6	like	like	ADP
ctmj-146	84	7	doxorubicin	doxorubicin	PROPN
ctmj-146	84	8	and	and	CCONJ
ctmj-146	84	9	5	5	NUM
ctmj-146	84	10	-	-	PUNCT
ctmj-146	84	11	fluorouracil	fluorouracil	NOUN
ctmj-146	84	12	,	,	PUNCT
ctmj-146	84	13	the	the	DET
ctmj-146	84	14	natural	natural	ADJ
ctmj-146	84	15	product	product	NOUN
ctmj-146	84	16	lipoic	lipoic	NOUN
ctmj-146	84	17	acid	acid	NOUN
ctmj-146	84	18	leads	lead	VERB
ctmj-146	84	19	to	to	ADP
ctmj-146	84	20	the	the	DET
ctmj-146	84	21	synergistic	synergistic	ADJ
ctmj-146	84	22	killing	killing	NOUN
ctmj-146	84	23	of	of	ADP
ctmj-146	84	24	colorectal	colorectal	ADJ
ctmj-146	84	25	cancer	cancer	NOUN
ctmj-146	84	26	cells	cell	NOUN
ctmj-146	84	27	in	in	ADP
ctmj-146	84	28	a	a	DET
ctmj-146	84	29	p53	p53	NOUN
ctmj-146	84	30	-	-	PUNCT
ctmj-146	84	31	dependent	dependent	ADJ
ctmj-146	84	32	manner	manner	NOUN
ctmj-146	84	33	.	.	PUNCT
ctmj-146	85	1	it	it	PRON
ctmj-146	85	2	also	also	ADV
ctmj-146	85	3	induces	induce	VERB
ctmj-146	85	4	ubiquitination	ubiquitination	NOUN
ctmj-146	85	5	and	and	CCONJ
ctmj-146	85	6	proteasomal	proteasomal	ADJ
ctmj-146	85	7	degradation	degradation	NOUN
ctmj-146	85	8	of	of	ADP
ctmj-146	85	9	p53	p53	NOUN
ctmj-146	85	10	in	in	ADP
ctmj-146	85	11	various	various	ADJ
ctmj-146	85	12	colorectal	colorectal	ADJ
ctmj-146	85	13	cancer	cancer	NOUN
ctmj-146	85	14	cell	cell	NOUN
ctmj-146	85	15	lines.43	lines.43	VERB
ctmj-146	85	16	the	the	DET
ctmj-146	85	17	anticancer	anticancer	NOUN
ctmj-146	85	18	effects	effect	NOUN
ctmj-146	85	19	of	of	ADP
ctmj-146	85	20	other	other	ADJ
ctmj-146	85	21	medications	medication	NOUN
ctmj-146	85	22	that	that	PRON
ctmj-146	85	23	may	may	AUX
ctmj-146	85	24	cause	cause	VERB
ctmj-146	85	25	the	the	DET
ctmj-146	85	26	mutant	mutant	ADJ
ctmj-146	85	27	p53	p53	NOUN
ctmj-146	85	28	protein	protein	NOUN
ctmj-146	85	29	to	to	PART
ctmj-146	85	30	degrade	degrade	VERB
ctmj-146	85	31	are	be	AUX
ctmj-146	85	32	encouraging.44	encouraging.44	NOUN
ctmj-146	85	33	a	a	DET
ctmj-146	85	34	number	number	NOUN
ctmj-146	85	35	of	of	ADP
ctmj-146	85	36	malignancies	malignancy	NOUN
ctmj-146	85	37	,	,	PUNCT
ctmj-146	85	38	including	include	VERB
ctmj-146	85	39	colorectal	colorectal	NOUN
ctmj-146	85	40	and	and	CCONJ
ctmj-146	85	41	osteosarcoma	osteosarcoma	ADJ
ctmj-146	85	42	,	,	PUNCT
ctmj-146	85	43	have	have	AUX
ctmj-146	85	44	shown	show	VERB
ctmj-146	85	45	promise	promise	NOUN
ctmj-146	85	46	when	when	SCONJ
ctmj-146	85	47	treated	treat	VERB
ctmj-146	85	48	with	with	ADP
ctmj-146	85	49	therapeutic	therapeutic	ADJ
ctmj-146	85	50	strategies	strategy	NOUN
ctmj-146	85	51	that	that	PRON
ctmj-146	85	52	target	target	VERB
ctmj-146	85	53	mutant	mutant	ADJ
ctmj-146	85	54	p53.45	p53.45	NOUN
ctmj-146	85	55	another	another	DET
ctmj-146	85	56	alkaloid	alkaloid	NOUN
ctmj-146	85	57	from	from	ADP
ctmj-146	85	58	buxus	buxus	PROPN
ctmj-146	85	59	that	that	PRON
ctmj-146	85	60	deserves	deserve	VERB
ctmj-146	85	61	particular	particular	ADJ
ctmj-146	85	62	notice	notice	NOUN
ctmj-146	85	63	for	for	ADP
ctmj-146	85	64	its	its	PRON
ctmj-146	85	65	biological	biological	ADJ
ctmj-146	85	66	activities	activity	NOUN
ctmj-146	85	67	is	be	AUX
ctmj-146	85	68	ebuxenone	ebuxenone	NOUN
ctmj-146	85	69	,	,	PUNCT
ctmj-146	85	70	which	which	PRON
ctmj-146	85	71	is	be	AUX
ctmj-146	85	72	derived	derive	VERB
ctmj-146	85	73	from	from	ADP
ctmj-146	85	74	buxus	buxus	PROPN
ctmj-146	85	75	hyrcana	hyrcana	PROPN
ctmj-146	85	76	.	.	PUNCT
ctmj-146	86	1	it	it	PRON
ctmj-146	86	2	has	have	AUX
ctmj-146	86	3	been	be	AUX
ctmj-146	86	4	shown	show	VERB
ctmj-146	86	5	to	to	PART
ctmj-146	86	6	inhibit	inhibit	VERB
ctmj-146	86	7	the	the	DET
ctmj-146	86	8	proliferation	proliferation	NOUN
ctmj-146	86	9	of	of	ADP
ctmj-146	86	10	t	t	NOUN
ctmj-146	86	11	cells	cell	NOUN
ctmj-146	86	12	triggered	trigger	VERB
ctmj-146	86	13	by	by	ADP
ctmj-146	86	14	phytohemagglutinin	phytohemagglutinin	NOUN
ctmj-146	86	15	.	.	PUNCT
ctmj-146	87	1	curiously	curiously	ADV
ctmj-146	87	2	,	,	PUNCT
ctmj-146	87	3	a	a	DET
ctmj-146	87	4	molecular	molecular	ADJ
ctmj-146	87	5	modeling	modeling	NOUN
ctmj-146	87	6	research	research	NOUN
ctmj-146	87	7	suggested	suggest	VERB
ctmj-146	87	8	that	that	SCONJ
ctmj-146	87	9	ebuxenone	ebuxenone	NOUN
ctmj-146	87	10	and	and	CCONJ
ctmj-146	87	11	its	its	PRON
ctmj-146	87	12	analog	analog	NOUN
ctmj-146	87	13	buxidin	buxidin	VERB
ctmj-146	87	14	directly	directly	ADV
ctmj-146	87	15	interact	interact	VERB
ctmj-146	87	16	with	with	ADP
ctmj-146	87	17	il-2	il-2	NUM
ctmj-146	87	18	,	,	PUNCT
ctmj-146	87	19	and	and	CCONJ
ctmj-146	87	20	both	both	DET
ctmj-146	87	21	compounds	compound	NOUN
ctmj-146	87	22	were	be	AUX
ctmj-146	87	23	discovered	discover	VERB
ctmj-146	87	24	to	to	PART
ctmj-146	87	25	reduce	reduce	VERB
ctmj-146	87	26	il-2	il-2	NUM
ctmj-146	87	27	and	and	CCONJ
ctmj-146	87	28	il-4	il-4	NOUN
ctmj-146	87	29	production	production	NOUN
ctmj-146	87	30	in	in	ADP
ctmj-146	87	31	a	a	DET
ctmj-146	87	32	dosedependent	dosedependent	NOUN
ctmj-146	87	33	manner	manner	NOUN
ctmj-146	87	34	(	(	PUNCT
ctmj-146	87	35	fig	fig	NOUN
ctmj-146	87	36	.	.	PUNCT
ctmj-146	88	1	2).46	2).46	NUM
ctmj-146	88	2	although	although	SCONJ
ctmj-146	88	3	experimental	experimental	ADJ
ctmj-146	88	4	confirmation	confirmation	NOUN
ctmj-146	88	5	of	of	ADP
ctmj-146	88	6	this	this	PRON
ctmj-146	88	7	in	in	ADP
ctmj-146	88	8	silico	silico	NOUN
ctmj-146	88	9	prediction	prediction	NOUN
ctmj-146	88	10	is	be	AUX
ctmj-146	88	11	still	still	ADV
ctmj-146	88	12	pending	pende	VERB
ctmj-146	88	13	,	,	PUNCT
ctmj-146	88	14	e	e	NOUN
ctmj-146	88	15	-	-	NOUN
ctmj-146	88	16	buxenone	buxenone	NOUN
ctmj-146	88	17	and	and	CCONJ
ctmj-146	88	18	buxidin	buxidin	NOUN
ctmj-146	88	19	's	's	PART
ctmj-146	88	20	immunosuppressive	immunosuppressive	ADJ
ctmj-146	88	21	characteristics	characteristic	NOUN
ctmj-146	88	22	may	may	AUX
ctmj-146	88	23	be	be	AUX
ctmj-146	88	24	therapeutic	therapeutic	ADJ
ctmj-146	88	25	in	in	ADP
ctmj-146	88	26	a	a	DET
ctmj-146	88	27	variety	variety	NOUN
ctmj-146	88	28	of	of	ADP
ctmj-146	88	29	diseases	disease	NOUN
ctmj-146	88	30	.	.	PUNCT
ctmj-146	89	1	cvb	cvb	VERB
ctmj-146	89	2	-	-	PUNCT
ctmj-146	89	3	d	d	ADJ
ctmj-146	89	4	molecular	molecular	ADJ
ctmj-146	89	5	targets	target	NOUN
ctmj-146	89	6	?	?	PUNCT
ctmj-146	90	1	the	the	DET
ctmj-146	90	2	cyclovirobuxine	cyclovirobuxine	PROPN
ctmj-146	90	3	literature	literature	PROPN
ctmj-146	90	4	review	review	PROPN
ctmj-146	90	5	and	and	CCONJ
ctmj-146	90	6	associated	associated	ADJ
ctmj-146	90	7	product	product	NOUN
ctmj-146	90	8	brought	bring	VERB
ctmj-146	90	9	attention	attention	NOUN
ctmj-146	90	10	to	to	ADP
ctmj-146	90	11	an	an	DET
ctmj-146	90	12	underappreciated	underappreciated	ADJ
ctmj-146	90	13	category	category	NOUN
ctmj-146	90	14	of	of	ADP
ctmj-146	90	15	all	all	DET
ctmj-146	90	16	-	-	PUNCT
ctmj-146	90	17	natural	natural	ADJ
ctmj-146	90	18	goods	good	NOUN
ctmj-146	90	19	.	.	PUNCT
ctmj-146	91	1	cvb	cvb	PROPN
ctmj-146	91	2	-	-	PUNCT
ctmj-146	91	3	d	d	PROPN
ctmj-146	91	4	seems	seem	VERB
ctmj-146	91	5	to	to	PART
ctmj-146	91	6	have	have	VERB
ctmj-146	91	7	helpful	helpful	ADJ
ctmj-146	91	8	anticancer	anticancer	NOUN
ctmj-146	91	9	characteristics	characteristic	NOUN
ctmj-146	91	10	in	in	ADP
ctmj-146	91	11	addition	addition	NOUN
ctmj-146	91	12	to	to	ADP
ctmj-146	91	13	its	its	PRON
ctmj-146	91	14	well	well	ADV
ctmj-146	91	15	-	-	PUNCT
ctmj-146	91	16	known	know	VERB
ctmj-146	91	17	vascular	vascular	ADJ
ctmj-146	91	18	protective	protective	ADJ
ctmj-146	91	19	benefits	benefit	NOUN
ctmj-146	91	20	.	.	PUNCT
ctmj-146	92	1	several	several	ADJ
ctmj-146	92	2	supplementary	supplementary	ADJ
ctmj-146	92	3	in	in	ADP
ctmj-146	92	4	vitro	vitro	X
ctmj-146	92	5	and	and	CCONJ
ctmj-146	92	6	in	in	ADP
ctmj-146	92	7	vivo	vivo	ADJ
ctmj-146	92	8	experimental	experimental	ADJ
ctmj-146	92	9	models	model	NOUN
ctmj-146	92	10	have	have	AUX
ctmj-146	92	11	now	now	ADV
ctmj-146	92	12	shown	show	VERB
ctmj-146	92	13	its	its	PRON
ctmj-146	92	14	anti	anti	ADJ
ctmj-146	92	15	-	-	ADJ
ctmj-146	92	16	tumor	tumor	ADJ
ctmj-146	92	17	efficacy	efficacy	NOUN
ctmj-146	92	18	.	.	PUNCT
ctmj-146	93	1	although	although	SCONJ
ctmj-146	93	2	the	the	DET
ctmj-146	93	3	amount	amount	NOUN
ctmj-146	93	4	of	of	ADP
ctmj-146	93	5	activity	activity	NOUN
ctmj-146	93	6	is	be	AUX
ctmj-146	93	7	not	not	PART
ctmj-146	93	8	very	very	ADV
ctmj-146	93	9	high	high	ADJ
ctmj-146	93	10	,	,	PUNCT
ctmj-146	93	11	it	it	PRON
ctmj-146	93	12	is	be	AUX
ctmj-146	93	13	noticeable	noticeable	ADJ
ctmj-146	93	14	in	in	ADP
ctmj-146	93	15	models	model	NOUN
ctmj-146	93	16	of	of	ADP
ctmj-146	93	17	colon	colon	NOUN
ctmj-146	93	18	and	and	CCONJ
ctmj-146	93	19	liver	liver	NOUN
ctmj-146	93	20	cancer.24	cancer.24	NOUN
ctmj-146	93	21	,	,	PUNCT
ctmj-146	93	22	26	26	NUM
ctmj-146	93	23	to	to	PART
ctmj-146	93	24	fully	fully	ADV
ctmj-146	93	25	understand	understand	VERB
ctmj-146	93	26	the	the	DET
ctmj-146	93	27	drug	drug	NOUN
ctmj-146	93	28	's	's	PART
ctmj-146	93	29	potential	potential	NOUN
ctmj-146	93	30	,	,	PUNCT
ctmj-146	93	31	more	more	ADJ
ctmj-146	93	32	in	in	ADP
ctmj-146	93	33	vivo	vivo	ADJ
ctmj-146	93	34	trials	trial	NOUN
ctmj-146	93	35	using	use	VERB
ctmj-146	93	36	other	other	ADJ
ctmj-146	93	37	models	model	NOUN
ctmj-146	93	38	and	and	CCONJ
ctmj-146	93	39	in	in	ADP
ctmj-146	93	40	conjunction	conjunction	NOUN
ctmj-146	93	41	with	with	ADP
ctmj-146	93	42	current	current	ADJ
ctmj-146	93	43	anti	anti	ADJ
ctmj-146	93	44	-	-	ADJ
ctmj-146	93	45	tumor	tumor	ADJ
ctmj-146	93	46	medications	medication	NOUN
ctmj-146	93	47	are	be	AUX
ctmj-146	93	48	necessary	necessary	ADJ
ctmj-146	93	49	.	.	PUNCT
ctmj-146	94	1	in	in	ADP
ctmj-146	94	2	order	order	NOUN
ctmj-146	94	3	to	to	PART
ctmj-146	94	4	guide	guide	VERB
ctmj-146	94	5	the	the	DET
ctmj-146	94	6	selection	selection	NOUN
ctmj-146	94	7	of	of	ADP
ctmj-146	94	8	medication	medication	NOUN
ctmj-146	94	9	combinations	combination	NOUN
ctmj-146	94	10	and	and	CCONJ
ctmj-146	94	11	develop	develop	VERB
ctmj-146	94	12	optimum	optimum	ADJ
ctmj-146	94	13	protocols	protocol	NOUN
ctmj-146	94	14	,	,	PUNCT
ctmj-146	94	15	however	however	ADV
ctmj-146	94	16	,	,	PUNCT
ctmj-146	94	17	a	a	DET
ctmj-146	94	18	better	well	ADJ
ctmj-146	94	19	understanding	understanding	NOUN
ctmj-146	94	20	of	of	ADP
ctmj-146	94	21	its	its	PRON
ctmj-146	94	22	mechanism	mechanism	NOUN
ctmj-146	94	23	of	of	ADP
ctmj-146	94	24	action	action	NOUN
ctmj-146	94	25	and	and	CCONJ
ctmj-146	94	26	its	its	PRON
ctmj-146	94	27	targets	target	NOUN
ctmj-146	94	28	is	be	AUX
ctmj-146	94	29	required	require	VERB
ctmj-146	94	30	.	.	PUNCT
ctmj-146	95	1	as	as	ADP
ctmj-146	95	2	of	of	ADP
ctmj-146	95	3	right	right	ADV
ctmj-146	95	4	now	now	ADV
ctmj-146	95	5	,	,	PUNCT
ctmj-146	95	6	this	this	PRON
ctmj-146	95	7	is	be	AUX
ctmj-146	95	8	the	the	DET
ctmj-146	95	9	only	only	ADJ
ctmj-146	95	10	restriction	restriction	NOUN
ctmj-146	95	11	on	on	ADP
ctmj-146	95	12	this	this	DET
ctmj-146	95	13	newly	newly	ADV
ctmj-146	95	14	revealed	reveal	VERB
ctmj-146	95	15	anticancer	anticancer	NOUN
ctmj-146	95	16	drug	drug	NOUN
ctmj-146	95	17	.	.	PUNCT
ctmj-146	96	1	where	where	SCONJ
ctmj-146	96	2	does	do	AUX
ctmj-146	96	3	cvb	cvb	VERB
ctmj-146	96	4	-	-	PUNCT
ctmj-146	96	5	d	d	NOUN
ctmj-146	96	6	aim	aim	VERB
ctmj-146	96	7	its	its	PRON
ctmj-146	96	8	molecular	molecular	ADJ
ctmj-146	96	9	attacks	attack	NOUN
ctmj-146	96	10	?	?	PUNCT
ctmj-146	97	1	we	we	PRON
ctmj-146	97	2	may	may	AUX
ctmj-146	97	3	go	go	VERB
ctmj-146	97	4	to	to	ADP
ctmj-146	97	5	research	research	NOUN
ctmj-146	97	6	in	in	ADP
ctmj-146	97	7	an	an	DET
ctmj-146	97	8	effort	effort	NOUN
ctmj-146	97	9	to	to	PART
ctmj-146	97	10	shed	shed	VERB
ctmj-146	97	11	light	light	NOUN
ctmj-146	97	12	on	on	ADP
ctmj-146	97	13	this	this	DET
ctmj-146	97	14	mystery	mystery	NOUN
ctmj-146	97	15	.	.	PUNCT
ctmj-146	98	1	carried	carry	VERB
ctmj-146	98	2	out	out	ADP
ctmj-146	98	3	using	use	VERB
ctmj-146	98	4	cvb	cvb	PROPN
ctmj-146	98	5	-	-	PUNCT
ctmj-146	98	6	d	d	NOUN
ctmj-146	98	7	or	or	CCONJ
ctmj-146	98	8	other	other	ADJ
ctmj-146	98	9	naturally	naturally	ADV
ctmj-146	98	10	occurring	occur	VERB
ctmj-146	98	11	compounds	compound	NOUN
ctmj-146	98	12	belonging	belong	VERB
ctmj-146	98	13	to	to	ADP
ctmj-146	98	14	the	the	DET
ctmj-146	98	15	same	same	ADJ
ctmj-146	98	16	chemical	chemical	NOUN
ctmj-146	98	17	class	class	NOUN
ctmj-146	98	18	.	.	PUNCT
ctmj-146	99	1	in	in	ADP
ctmj-146	99	2	the	the	DET
ctmj-146	99	3	first	first	ADJ
ctmj-146	99	4	scenario	scenario	NOUN
ctmj-146	99	5	,	,	PUNCT
ctmj-146	99	6	target	target	NOUN
ctmj-146	99	7	suggestions	suggestion	NOUN
ctmj-146	99	8	obtained	obtain	VERB
ctmj-146	99	9	from	from	ADP
ctmj-146	99	10	in	in	ADP
ctmj-146	99	11	silico	silico	NOUN
ctmj-146	99	12	research	research	NOUN
ctmj-146	99	13	are	be	AUX
ctmj-146	99	14	our	our	PRON
ctmj-146	99	15	exclusive	exclusive	ADJ
ctmj-146	99	16	option	option	NOUN
ctmj-146	99	17	because	because	SCONJ
ctmj-146	99	18	to	to	ADP
ctmj-146	99	19	the	the	DET
ctmj-146	99	20	lack	lack	NOUN
ctmj-146	99	21	of	of	ADP
ctmj-146	99	22	drug	drug	NOUN
ctmj-146	99	23	-	-	PUNCT
ctmj-146	99	24	target	target	NOUN
ctmj-146	99	25	structural	structural	ADJ
ctmj-146	99	26	investigations	investigation	NOUN
ctmj-146	99	27	.	.	PUNCT
ctmj-146	100	1	above	above	ADV
ctmj-146	100	2	,	,	PUNCT
ctmj-146	100	3	we	we	PRON
ctmj-146	100	4	noted	note	VERB
ctmj-146	100	5	that	that	SCONJ
ctmj-146	100	6	the	the	DET
ctmj-146	100	7	drug	drug	NOUN
ctmj-146	100	8	's	's	PART
ctmj-146	100	9	protective	protective	ADJ
ctmj-146	100	10	impact	impact	NOUN
ctmj-146	100	11	against	against	ADP
ctmj-146	100	12	oxidative	oxidative	ADJ
ctmj-146	100	13	stress	stress	NOUN
ctmj-146	100	14	in	in	ADP
ctmj-146	100	15	cardiomyocytes	cardiomyocyte	NOUN
ctmj-146	100	16	might	might	AUX
ctmj-146	100	17	be	be	AUX
ctmj-146	100	18	explained	explain	VERB
ctmj-146	100	19	by	by	ADP
ctmj-146	100	20	a	a	DET
ctmj-146	100	21	modeled	model	VERB
ctmj-146	100	22	direct	direct	ADJ
ctmj-146	100	23	interaction	interaction	NOUN
ctmj-146	100	24	of	of	ADP
ctmj-146	100	25	cvb	cvb	PROPN
ctmj-146	100	26	-	-	PROPN
ctmj-146	100	27	d	d	PROPN
ctmj-146	100	28	with	with	ADP
ctmj-146	100	29	the	the	DET
ctmj-146	100	30	nrf	nrf	ADJ
ctmj-146	100	31	2	2	NUM
ctmj-146	100	32	-	-	PUNCT
ctmj-146	100	33	keap	keap	NOUN
ctmj-146	100	34	1	1	NUM
ctmj-146	100	35	complex.28	complex.28	NOUN
ctmj-146	100	36	the	the	DET
ctmj-146	100	37	medication	medication	NOUN
ctmj-146	100	38	may	may	AUX
ctmj-146	100	39	be	be	AUX
ctmj-146	100	40	able	able	ADJ
ctmj-146	100	41	to	to	PART
ctmj-146	100	42	fit	fit	VERB
ctmj-146	100	43	into	into	ADP
ctmj-146	100	44	a	a	DET
ctmj-146	100	45	binding	bind	VERB
ctmj-146	100	46	pocket	pocket	NOUN
ctmj-146	100	47	in	in	ADP
ctmj-146	100	48	the	the	DET
ctmj-146	100	49	nrf2keap1	nrf2keap1	PROPN
ctmj-146	100	50	complex	complex	NOUN
ctmj-146	100	51	,	,	PUNCT
ctmj-146	100	52	as	as	SCONJ
ctmj-146	100	53	revealed	reveal	VERB
ctmj-146	100	54	by	by	ADP
ctmj-146	100	55	the	the	DET
ctmj-146	100	56	docking	docking	NOUN
ctmj-146	100	57	research	research	NOUN
ctmj-146	100	58	.	.	PUNCT
ctmj-146	101	1	this	this	PRON
ctmj-146	101	2	would	would	AUX
ctmj-146	101	3	lower	lower	VERB
ctmj-146	101	4	the	the	DET
ctmj-146	101	5	complex	complex	NOUN
ctmj-146	101	6	's	's	PART
ctmj-146	101	7	binding	binding	ADJ
ctmj-146	101	8	free	free	ADJ
ctmj-146	101	9	energy	energy	NOUN
ctmj-146	101	10	and	and	CCONJ
ctmj-146	101	11	disrupt	disrupt	VERB
ctmj-146	101	12	the	the	DET
ctmj-146	101	13	connection	connection	NOUN
ctmj-146	101	14	between	between	ADP
ctmj-146	101	15	nrf2	nrf2	PROPN
ctmj-146	101	16	and	and	CCONJ
ctmj-146	101	17	keap1	keap1	PROPN
ctmj-146	101	18	.	.	PUNCT
ctmj-146	102	1	consequently	consequently	ADV
ctmj-146	102	2	,	,	PUNCT
ctmj-146	102	3	cvb	cvb	PROPN
ctmj-146	102	4	-	-	PUNCT
ctmj-146	102	5	d	d	PROPN
ctmj-146	102	6	would	would	AUX
ctmj-146	102	7	encourage	encourage	VERB
ctmj-146	102	8	nrf2	nrf2	NOUN
ctmj-146	102	9	nuclear	nuclear	ADJ
ctmj-146	102	10	translocation	translocation	NOUN
ctmj-146	102	11	and	and	CCONJ
ctmj-146	102	12	activate	activate	VERB
ctmj-146	102	13	its	its	PRON
ctmj-146	102	14	downstream	downstream	ADJ
ctmj-146	102	15	signaling	signal	VERB
ctmj-146	102	16	pathways	pathway	NOUN
ctmj-146	102	17	,	,	PUNCT
ctmj-146	102	18	resulting	result	VERB
ctmj-146	102	19	in	in	ADP
ctmj-146	102	20	oxidative	oxidative	ADJ
ctmj-146	102	21	stress	stress	NOUN
ctmj-146	102	22	attenuation.28	attenuation.28	PROPN
ctmj-146	102	23	additional	additional	ADJ
ctmj-146	102	24	tiny	tiny	ADJ
ctmj-146	102	25	compounds	compound	NOUN
ctmj-146	102	26	that	that	PRON
ctmj-146	102	27	can	can	AUX
ctmj-146	102	28	there	there	PRON
ctmj-146	102	29	are	be	VERB
ctmj-146	102	30	known	know	VERB
ctmj-146	102	31	compounds	compound	NOUN
ctmj-146	102	32	that	that	PRON
ctmj-146	102	33	disrupt	disrupt	VERB
ctmj-146	102	34	nrf2keap1	nrf2keap1	ADJ
ctmj-146	102	35	complexes	complex	NOUN
ctmj-146	102	36	,	,	PUNCT
ctmj-146	102	37	such	such	ADJ
ctmj-146	102	38	as	as	ADP
ctmj-146	102	39	quercetin	quercetin	NOUN
ctmj-146	102	40	(	(	PUNCT
ctmj-146	102	41	3,40	3,40	NUM
ctmj-146	102	42	such	such	ADJ
ctmj-146	102	43	compounds	compound	NOUN
ctmj-146	102	44	as	as	ADP
ctmj-146	102	45	diglucoside	diglucoside	ADJ
ctmj-146	102	46	,	,	PUNCT
ctmj-146	102	47	esculin	esculin	NOUN
ctmj-146	102	48	,	,	PUNCT
ctmj-146	102	49	and	and	CCONJ
ctmj-146	102	50	salvianolic	salvianolic	ADJ
ctmj-146	102	51	acid	acid	NOUN
ctmj-146	102	52	a)47	a)47	PROPN
ctmj-146	102	53	do	do	AUX
ctmj-146	102	54	not	not	PART
ctmj-146	102	55	have	have	VERB
ctmj-146	102	56	strong	strong	ADJ
ctmj-146	102	57	treatments	treatment	NOUN
ctmj-146	102	58	for	for	ADP
ctmj-146	102	59	cancer	cancer	NOUN
ctmj-146	102	60	.	.	PUNCT
ctmj-146	103	1	we	we	PRON
ctmj-146	103	2	think	think	VERB
ctmj-146	103	3	that	that	SCONJ
ctmj-146	103	4	cvb	cvb	PROPN
ctmj-146	103	5	-	-	PUNCT
ctmj-146	103	6	d	d	PROPN
ctmj-146	103	7	's	's	PART
ctmj-146	103	8	anticancer	anticancer	NOUN
ctmj-146	103	9	activity	activity	NOUN
ctmj-146	103	10	ca	can	AUX
ctmj-146	103	11	n't	not	PART
ctmj-146	103	12	be	be	AUX
ctmj-146	103	13	explained	explain	VERB
ctmj-146	103	14	by	by	ADP
ctmj-146	103	15	this	this	DET
ctmj-146	103	16	target	target	NOUN
ctmj-146	103	17	interaction	interaction	NOUN
ctmj-146	103	18	alone	alone	ADV
ctmj-146	103	19	;	;	PUNCT
ctmj-146	103	20	other	other	ADJ
ctmj-146	103	21	targets	target	NOUN
ctmj-146	103	22	are	be	AUX
ctmj-146	103	23	required	require	VERB
ctmj-146	103	24	.	.	PUNCT
ctmj-146	104	1	the	the	DET
ctmj-146	104	2	anticancer	anticancer	NOUN
ctmj-146	104	3	impact	impact	NOUN
ctmj-146	104	4	was	be	AUX
ctmj-146	104	5	shown	show	VERB
ctmj-146	104	6	to	to	PART
ctmj-146	104	7	be	be	AUX
ctmj-146	104	8	mediated	mediate	VERB
ctmj-146	104	9	in	in	ADP
ctmj-146	104	10	part	part	NOUN
ctmj-146	104	11	by	by	ADP
ctmj-146	104	12	the	the	DET
ctmj-146	104	13	secreted	secrete	VERB
ctmj-146	104	14	protein	protein	NOUN
ctmj-146	104	15	cthrc1	cthrc1	NOUN
ctmj-146	104	16	(	(	PUNCT
ctmj-146	104	17	collagen	collagen	NOUN
ctmj-146	104	18	triple	triple	ADJ
ctmj-146	104	19	helix	helix	ADJ
ctmj-146	104	20	repeat	repeat	NOUN
ctmj-146	104	21	containing-1	containing-1	NUM
ctmj-146	104	22	)	)	PUNCT
ctmj-146	104	23	,	,	PUNCT
ctmj-146	104	24	according	accord	VERB
ctmj-146	104	25	to	to	ADP
ctmj-146	104	26	another	another	DET
ctmj-146	104	27	research	research	NOUN
ctmj-146	104	28	(	(	PUNCT
ctmj-146	104	29	fig	fig	NOUN
ctmj-146	104	30	.	.	PUNCT
ctmj-146	105	1	3).25	3).25	NOUN
ctmj-146	105	2	the	the	DET
ctmj-146	105	3	antiproliferative	antiproliferative	ADJ
ctmj-146	105	4	action	action	NOUN
ctmj-146	105	5	of	of	ADP
ctmj-146	105	6	cvb	cvb	PROPN
ctmj-146	105	7	-	-	PROPN
ctmj-146	105	8	d	d	PROPN
ctmj-146	105	9	was	be	AUX
ctmj-146	105	10	diminished	diminish	VERB
ctmj-146	105	11	when	when	SCONJ
ctmj-146	105	12	cthrc1	cthrc1	PROPN
ctmj-146	105	13	was	be	AUX
ctmj-146	105	14	knocked	knock	VERB
ctmj-146	105	15	down	down	ADP
ctmj-146	105	16	using	use	VERB
ctmj-146	105	17	sirna	sirna	PROPN
ctmj-146	105	18	.	.	PUNCT
ctmj-146	106	1	several	several	ADJ
ctmj-146	106	2	studies	study	NOUN
ctmj-146	106	3	shown	show	VERB
ctmj-146	106	4	that	that	SCONJ
ctmj-146	106	5	cvb	cvb	PROPN
ctmj-146	106	6	-	-	PUNCT
ctmj-146	106	7	d	d	PROPN
ctmj-146	106	8	inhibited	inhibited	ADJ
ctmj-146	106	9	colorectal	colorectal	ADJ
ctmj-146	106	10	cell	cell	NOUN
ctmj-146	106	11	proliferation	proliferation	NOUN
ctmj-146	106	12	via	via	ADP
ctmj-146	106	13	a	a	DET
ctmj-146	106	14	cthrc1	cthrc1	NOUN
ctmj-146	106	15	-	-	PUNCT
ctmj-146	106	16	dependent	dependent	ADJ
ctmj-146	106	17	pathway	pathway	NOUN
ctmj-146	106	18	.	.	PUNCT
ctmj-146	107	1	even	even	ADV
ctmj-146	107	2	while	while	SCONJ
ctmj-146	107	3	this	this	PRON
ctmj-146	107	4	does	do	AUX
ctmj-146	107	5	n't	not	PART
ctmj-146	107	6	prove	prove	VERB
ctmj-146	107	7	that	that	SCONJ
ctmj-146	107	8	cthrc1	cthrc1	PROPN
ctmj-146	107	9	is	be	AUX
ctmj-146	107	10	a	a	DET
ctmj-146	107	11	molecular	molecular	ADJ
ctmj-146	107	12	target	target	NOUN
ctmj-146	107	13	of	of	ADP
ctmj-146	107	14	cvb	cvb	PROPN
ctmj-146	107	15	-	-	PROPN
ctmj-146	107	16	d	d	PROPN
ctmj-146	107	17	,	,	PUNCT
ctmj-146	107	18	it	it	PRON
ctmj-146	107	19	does	do	AUX
ctmj-146	107	20	show	show	VERB
ctmj-146	107	21	that	that	SCONJ
ctmj-146	107	22	it	it	PRON
ctmj-146	107	23	is	be	AUX
ctmj-146	107	24	involved	involve	VERB
ctmj-146	107	25	in	in	ADP
ctmj-146	107	26	its	its	PRON
ctmj-146	107	27	action.25	action.25	ADJ
ctmj-146	107	28	recent	recent	ADJ
ctmj-146	107	29	research	research	NOUN
ctmj-146	107	30	has	have	AUX
ctmj-146	107	31	identified	identify	VERB
ctmj-146	107	32	this	this	DET
ctmj-146	107	33	protein	protein	NOUN
ctmj-146	107	34	as	as	ADP
ctmj-146	107	35	a	a	DET
ctmj-146	107	36	key	key	ADJ
ctmj-146	107	37	regulator	regulator	NOUN
ctmj-146	107	38	of	of	ADP
ctmj-146	107	39	both	both	DET
ctmj-146	107	40	primary	primary	ADJ
ctmj-146	107	41	tumor	tumor	NOUN
ctmj-146	107	42	development	development	NOUN
ctmj-146	107	43	and	and	CCONJ
ctmj-146	107	44	the	the	DET
ctmj-146	107	45	metastasis	metastasis	NOUN
ctmj-146	107	46	of	of	ADP
ctmj-146	107	47	cancer	cancer	NOUN
ctmj-146	107	48	cells	cell	NOUN
ctmj-146	107	49	to	to	ADP
ctmj-146	107	50	other	other	ADJ
ctmj-146	107	51	tissues.48	tissues.48	NOUN
ctmj-146	107	52	out	out	ADP
ctmj-146	107	53	of	of	ADP
ctmj-146	107	54	49	49	NUM
ctmj-146	107	55	colorectal	colorectal	ADJ
ctmj-146	107	56	cancer	cancer	NOUN
ctmj-146	107	57	,	,	PUNCT
ctmj-146	107	58	50	50	NUM
ctmj-146	107	59	osteosarcoma	osteosarcoma	ADJ
ctmj-146	107	60	,	,	PUNCT
ctmj-146	107	61	51	51	NUM
ctmj-146	107	62	hcc	hcc	NOUN
ctmj-146	107	63	,	,	PUNCT
ctmj-146	107	64	and	and	CCONJ
ctmj-146	107	65	endometriosis	endometriosis	NOUN
ctmj-146	107	66	are	be	AUX
ctmj-146	107	67	among	among	ADP
ctmj-146	107	68	the	the	DET
ctmj-146	107	69	diseases	disease	NOUN
ctmj-146	107	70	for	for	ADP
ctmj-146	107	71	which	which	PRON
ctmj-146	107	72	it	it	PRON
ctmj-146	107	73	is	be	AUX
ctmj-146	107	74	being	be	AUX
ctmj-146	107	75	evaluated	evaluate	VERB
ctmj-146	107	76	as	as	ADP
ctmj-146	107	77	a	a	DET
ctmj-146	107	78	potential	potential	ADJ
ctmj-146	107	79	predictive	predictive	ADJ
ctmj-146	107	80	biomarker	biomarker	NOUN
ctmj-146	107	81	and	and	CCONJ
ctmj-146	107	82	a	a	DET
ctmj-146	107	83	potential	potential	ADJ
ctmj-146	107	84	therapeutic	therapeutic	ADJ
ctmj-146	107	85	target.53	target.53	NOUN
ctmj-146	107	86	intriguingly	intriguingly	ADV
ctmj-146	107	87	,	,	PUNCT
ctmj-146	107	88	a	a	DET
ctmj-146	107	89	cervical	cervical	ADJ
ctmj-146	107	90	cancer	cancer	NOUN
ctmj-146	107	91	model	model	NOUN
ctmj-146	107	92	showed	show	VERB
ctmj-146	107	93	a	a	DET
ctmj-146	107	94	strong	strong	ADJ
ctmj-146	107	95	decrease	decrease	NOUN
ctmj-146	107	96	of	of	ADP
ctmj-146	107	97	tumor	tumor	NOUN
ctmj-146	107	98	cell	cell	NOUN
ctmj-146	107	99	metastasis	metastasis	NOUN
ctmj-146	107	100	when	when	SCONJ
ctmj-146	107	101	a	a	DET
ctmj-146	107	102	particular	particular	ADJ
ctmj-146	107	103	monoclonal	monoclonal	NOUN
ctmj-146	107	104	antibody	antibody	NOUN
ctmj-146	107	105	was	be	AUX
ctmj-146	107	106	used	use	VERB
ctmj-146	107	107	to	to	PART
ctmj-146	107	108	directly	directly	ADV
ctmj-146	107	109	block	block	VERB
ctmj-146	107	110	cthrc1.54	cthrc1.54	VERB
ctmj-146	107	111	similarly	similarly	ADV
ctmj-146	107	112	,	,	PUNCT
ctmj-146	107	113	a	a	DET
ctmj-146	107	114	xenograft	xenograft	NOUN
ctmj-146	107	115	model	model	NOUN
ctmj-146	107	116	revealed	reveal	VERB
ctmj-146	107	117	that	that	SCONJ
ctmj-146	107	118	the	the	DET
ctmj-146	107	119	protein	protein	NOUN
ctmj-146	107	120	enhanced	enhance	VERB
ctmj-146	107	121	the	the	DET
ctmj-146	107	122	metastatic	metastatic	ADJ
ctmj-146	107	123	spread	spread	NOUN
ctmj-146	107	124	of	of	ADP
ctmj-146	107	125	epithelial	epithelial	ADJ
ctmj-146	107	126	ovarian	ovarian	ADJ
ctmj-146	107	127	cancer	cancer	NOUN
ctmj-146	107	128	cells.55	cells.55	NOUN
ctmj-146	107	129	undoubtedly	undoubtedly	ADV
ctmj-146	107	130	,	,	PUNCT
ctmj-146	107	131	cthrc1	cthrc1	PROPN
ctmj-146	107	132	promotes	promote	VERB
ctmj-146	107	133	metastasis	metastasis	NOUN
ctmj-146	107	134	;	;	PUNCT
ctmj-146	107	135	hence	hence	ADV
ctmj-146	107	136	,	,	PUNCT
ctmj-146	107	137	it	it	PRON
ctmj-146	107	138	may	may	AUX
ctmj-146	107	139	be	be	AUX
ctmj-146	107	140	very	very	ADV
ctmj-146	107	141	beneficial	beneficial	ADJ
ctmj-146	107	142	to	to	PART
ctmj-146	107	143	enhance	enhance	VERB
ctmj-146	107	144	cancer	cancer	NOUN
ctmj-146	107	145	therapies	therapy	NOUN
ctmj-146	107	146	by	by	ADP
ctmj-146	107	147	down	down	ADV
ctmj-146	107	148	-	-	PUNCT
ctmj-146	107	149	regulating	regulate	VERB
ctmj-146	107	150	it	it	PRON
ctmj-146	107	151	using	use	VERB
ctmj-146	107	152	antibodies	antibody	NOUN
ctmj-146	107	153	or	or	CCONJ
ctmj-146	107	154	medications	medication	NOUN
ctmj-146	107	155	such	such	ADJ
ctmj-146	107	156	as	as	ADP
ctmj-146	107	157	cvb	cvb	PROPN
ctmj-146	107	158	-	-	PROPN
ctmj-146	107	159	d.	d.	PROPN
ctmj-146	107	160	at	at	ADP
ctmj-146	107	161	this	this	DET
ctmj-146	107	162	time	time	NOUN
ctmj-146	107	163	,	,	PUNCT
ctmj-146	107	164	no	no	DET
ctmj-146	107	165	medication	medication	NOUN
ctmj-146	107	166	has	have	AUX
ctmj-146	107	167	been	be	AUX
ctmj-146	107	168	identified	identify	VERB
ctmj-146	107	169	that	that	PRON
ctmj-146	107	170	interacts	interact	VERB
ctmj-146	107	171	directly	directly	ADV
ctmj-146	107	172	with	with	ADP
ctmj-146	107	173	cthrc1	cthrc1	PROPN
ctmj-146	107	174	.	.	PUNCT
ctmj-146	108	1	cvb	cvb	PROPN
ctmj-146	108	2	-	-	PROPN
ctmj-146	108	3	d	d	PROPN
ctmj-146	108	4	may	may	AUX
ctmj-146	108	5	be	be	AUX
ctmj-146	108	6	the	the	DET
ctmj-146	108	7	first	first	ADJ
ctmj-146	108	8	small	small	ADJ
ctmj-146	108	9	molecule	molecule	NOUN
ctmj-146	108	10	ligand	ligand	NOUN
ctmj-146	108	11	for	for	ADP
ctmj-146	108	12	this	this	DET
ctmj-146	108	13	receptor	receptor	NOUN
ctmj-146	108	14	.	.	PUNCT
ctmj-146	109	1	the	the	DET
ctmj-146	109	2	second	second	ADJ
ctmj-146	109	3	strategy	strategy	NOUN
ctmj-146	109	4	involves	involve	VERB
ctmj-146	109	5	searching	search	VERB
ctmj-146	109	6	for	for	ADP
ctmj-146	109	7	complementary	complementary	ADJ
ctmj-146	109	8	natural	natural	ADJ
ctmj-146	109	9	substances	substance	NOUN
ctmj-146	109	10	in	in	ADP
ctmj-146	109	11	the	the	DET
ctmj-146	109	12	same	same	ADJ
ctmj-146	109	13	class	class	NOUN
ctmj-146	109	14	of	of	ADP
ctmj-146	109	15	chemicals	chemical	NOUN
ctmj-146	109	16	and	and	CCONJ
ctmj-146	109	17	the	the	DET
ctmj-146	109	18	targets	target	NOUN
ctmj-146	109	19	that	that	PRON
ctmj-146	109	20	they	they	PRON
ctmj-146	109	21	interact	interact	VERB
ctmj-146	109	22	with	with	ADP
ctmj-146	109	23	.	.	PUNCT
ctmj-146	110	1	the	the	DET
ctmj-146	110	2	structural	structural	ADJ
ctmj-146	110	3	and	and	CCONJ
ctmj-146	110	4	functional	functional	ADJ
ctmj-146	110	5	diversity	diversity	NOUN
ctmj-146	110	6	of	of	ADP
ctmj-146	110	7	saponins	saponin	NOUN
ctmj-146	110	8	is	be	AUX
ctmj-146	110	9	astounding	astounding	ADJ
ctmj-146	110	10	.	.	PUNCT
ctmj-146	111	1	of	of	ADP
ctmj-146	111	2	the	the	DET
ctmj-146	111	3	various	various	ADJ
ctmj-146	111	4	subclasses	subclass	NOUN
ctmj-146	111	5	,	,	PUNCT
ctmj-146	111	6	there	there	PRON
ctmj-146	111	7	are	be	VERB
ctmj-146	111	8	as	as	ADV
ctmj-146	111	9	many	many	ADJ
ctmj-146	111	10	as	as	ADP
ctmj-146	111	11	eleven	eleven	NUM
ctmj-146	111	12	primary	primary	ADJ
ctmj-146	111	13	classes	class	NOUN
ctmj-146	111	14	(	(	PUNCT
ctmj-146	111	15	dammaranes	dammarane	NOUN
ctmj-146	111	16	,	,	PUNCT
ctmj-146	111	17	tirucallanes	tirucallane	NOUN
ctmj-146	111	18	,	,	PUNCT
ctmj-146	111	19	lupanes	lupane	NOUN
ctmj-146	111	20	,	,	PUNCT
ctmj-146	111	21	hopanes	hopane	NOUN
ctmj-146	111	22	,	,	PUNCT
ctmj-146	111	23	ole	ole	NOUN
ctmj-146	111	24	-	-	PUNCT
ctmj-146	111	25	ananes	anane	NOUN
ctmj-146	111	26	,	,	PUNCT
ctmj-146	111	27	taraxasteranes	taraxasterane	NOUN
ctmj-146	111	28	,	,	PUNCT
ctmj-146	111	29	ursanes	ursane	NOUN
ctmj-146	111	30	,	,	PUNCT
ctmj-146	111	31	cycloartanes	cycloartane	NOUN
ctmj-146	111	32	,	,	PUNCT
ctmj-146	111	33	lanostanes	lanostane	NOUN
ctmj-146	111	34	,	,	PUNCT
ctmj-146	111	35	cucurbitanes	cucurbitane	NOUN
ctmj-146	111	36	,	,	PUNCT
ctmj-146	111	37	and	and	CCONJ
ctmj-146	111	38	steroids).56	steroids).56	NOUN
ctmj-146	111	39	together	together	ADV
ctmj-146	111	40	,	,	PUNCT
ctmj-146	111	41	these	these	DET
ctmj-146	111	42	classes	class	NOUN
ctmj-146	111	43	provide	provide	VERB
ctmj-146	111	44	a	a	DET
ctmj-146	111	45	wide	wide	ADJ
ctmj-146	111	46	range	range	NOUN
ctmj-146	111	47	of	of	ADP
ctmj-146	111	48	potential	potential	ADJ
ctmj-146	111	49	applications	application	NOUN
ctmj-146	111	50	.	.	PUNCT
ctmj-146	112	1	many	many	ADJ
ctmj-146	112	2	substances	substance	NOUN
ctmj-146	112	3	that	that	PRON
ctmj-146	112	4	may	may	AUX
ctmj-146	112	5	be	be	AUX
ctmj-146	112	6	compared	compare	VERB
ctmj-146	112	7	to	to	ADP
ctmj-146	112	8	cvb	cvb	PROPN
ctmj-146	112	9	-	-	PUNCT
ctmj-146	112	10	d.	d.	PROPN
ctmj-146	112	11	anthracite	anthracite	PROPN
ctmj-146	112	12	,	,	PUNCT
ctmj-146	112	13	argentatin	argentatin	NOUN
ctmj-146	112	14	a	a	X
ctmj-146	112	15	,	,	PUNCT
ctmj-146	112	16	actein	actein	ADV
ctmj-146	112	17	,	,	PUNCT
ctmj-146	112	18	(	(	PUNCT
ctmj-146	112	19	23	23	NUM
ctmj-146	112	20	r	r	NOUN
ctmj-146	112	21	,	,	PUNCT
ctmj-146	112	22	24	24	NUM
ctmj-146	112	23	e)-23	e)-23	NOUN
ctmj-146	112	24	acetoxymangiferonic	acetoxymangiferonic	ADJ
ctmj-146	112	25	acid	acid	NOUN
ctmj-146	112	26	,	,	PUNCT
ctmj-146	112	27	and	and	CCONJ
ctmj-146	112	28	many	many	ADJ
ctmj-146	112	29	other	other	ADJ
ctmj-146	112	30	anticancer	anticancer	NOUN
ctmj-146	112	31	drugs	drug	NOUN
ctmj-146	112	32	are	be	AUX
ctmj-146	112	33	members	member	NOUN
ctmj-146	112	34	of	of	ADP
ctmj-146	112	35	the	the	DET
ctmj-146	112	36	cycloartanes	cycloartane	NOUN
ctmj-146	112	37	,	,	PUNCT
ctmj-146	112	38	the	the	DET
ctmj-146	112	39	saponin	saponin	ADJ
ctmj-146	112	40	class	class	NOUN
ctmj-146	112	41	most	most	ADV
ctmj-146	112	42	closely	closely	ADV
ctmj-146	112	43	related	relate	VERB
ctmj-146	112	44	to	to	ADP
ctmj-146	112	45	cvb	cvb	PROPN
ctmj-146	112	46	-	-	PROPN
ctmj-146	112	47	d.	d.	PROPN
ctmj-146	112	48	regrettably	regrettably	ADV
ctmj-146	112	49	,	,	PUNCT
ctmj-146	112	50	the	the	DET
ctmj-146	112	51	majority	majority	NOUN
ctmj-146	112	52	of	of	ADP
ctmj-146	112	53	these	these	DET
ctmj-146	112	54	drugs	drug	NOUN
ctmj-146	112	55	have	have	AUX
ctmj-146	112	56	had	have	VERB
ctmj-146	112	57	their	their	PRON
ctmj-146	112	58	anticancer	anticancer	NOUN
ctmj-146	112	59	effects	effect	NOUN
ctmj-146	112	60	studied	study	VERB
ctmj-146	112	61	,	,	PUNCT
ctmj-146	112	62	but	but	CCONJ
ctmj-146	112	63	not	not	PART
ctmj-146	112	64	their	their	PRON
ctmj-146	112	65	molecular	molecular	ADJ
ctmj-146	112	66	targets	target	NOUN
ctmj-146	112	67	.	.	PUNCT
ctmj-146	113	1	an	an	DET
ctmj-146	113	2	example	example	NOUN
ctmj-146	113	3	of	of	ADP
ctmj-146	113	4	a	a	DET
ctmj-146	113	5	rare	rare	ADJ
ctmj-146	113	6	situation	situation	NOUN
ctmj-146	113	7	where	where	SCONJ
ctmj-146	113	8	a	a	DET
ctmj-146	113	9	target	target	NOUN
ctmj-146	113	10	has	have	AUX
ctmj-146	113	11	been	be	AUX
ctmj-146	113	12	suggested	suggest	VERB
ctmj-146	113	13	is	be	AUX
ctmj-146	113	14	the	the	DET
ctmj-146	113	15	derivative	derivative	ADJ
ctmj-146	113	16	cycloartane-3,24,25	cycloartane-3,24,25	ADV
ctmj-146	113	17	-	-	PUNCT
ctmj-146	113	18	triol	triol	PROPN
ctmj-146	113	19	.	.	PUNCT
ctmj-146	114	1	it	it	PRON
ctmj-146	114	2	was	be	AUX
ctmj-146	114	3	discovered	discover	VERB
ctmj-146	114	4	that	that	SCONJ
ctmj-146	114	5	out	out	ADP
ctmj-146	114	6	of	of	ADP
ctmj-146	114	7	451	451	NUM
ctmj-146	114	8	kinases	kinase	NOUN
ctmj-146	114	9	tested	test	VERB
ctmj-146	114	10	,	,	PUNCT
ctmj-146	114	11	mrcka	mrcka	NOUN
ctmj-146	114	12	(	(	PUNCT
ctmj-146	114	13	myotonic	myotonic	ADJ
ctmj-146	114	14	dystrophy	dystrophy	NOUN
ctmj-146	114	15	protein	protein	NOUN
ctmj-146	114	16	kinase	kinase	NOUN
ctmj-146	114	17	-	-	PUNCT
ctmj-146	114	18	like	like	ADJ
ctmj-146	114	19	alpha	alpha	NOUN
ctmj-146	114	20	)	)	PUNCT
ctmj-146	114	21	inhibits	inhibit	VERB
ctmj-146	114	22	serine	serine	NOUN
ctmj-146	114	23	/	/	SYM
ctmj-146	114	24	threonine	threonine	ADJ
ctmj-146	114	25	protein	protein	NOUN
ctmj-146	114	26	kinase	kinase	NOUN
ctmj-146	114	27	activity	activity	NOUN
ctmj-146	114	28	with	with	ADP
ctmj-146	114	29	a	a	DET
ctmj-146	114	30	kd50	kd50	PROPN
ctmj-146	114	31	of	of	ADP
ctmj-146	114	32	0.26	0.26	NUM
ctmj-146	114	33	mm.60	mm.60	PROPN
ctmj-146	114	34	because	because	SCONJ
ctmj-146	114	35	of	of	ADP
ctmj-146	114	36	its	its	PRON
ctmj-146	114	37	function	function	NOUN
ctmj-146	114	38	in	in	ADP
ctmj-146	114	39	p53	p53	NOUN
ctmj-146	114	40	-	-	PUNCT
ctmj-146	114	41	dependent	dependent	ADJ
ctmj-146	114	42	autophagy	autophagy	NOUN
ctmj-146	114	43	,	,	PUNCT
ctmj-146	114	44	this	this	DET
ctmj-146	114	45	target	target	NOUN
ctmj-146	114	46	is	be	AUX
ctmj-146	114	47	intriguing.61	intriguing.61	NOUN
ctmj-146	114	48	,	,	PUNCT
ctmj-146	114	49	62	62	NUM
ctmj-146	114	50	aiming	aim	VERB
ctmj-146	114	51	to	to	ADP
ctmj-146	114	52	combat	combat	NOUN
ctmj-146	114	53	cancer	cancer	NOUN
ctmj-146	114	54	,	,	PUNCT
ctmj-146	114	55	researchers	researcher	NOUN
ctmj-146	114	56	are	be	AUX
ctmj-146	114	57	diligently	diligently	ADV
ctmj-146	114	58	seeking	seek	VERB
ctmj-146	114	59	small	small	ADJ
ctmj-146	114	60	-	-	PUNCT
ctmj-146	114	61	molecule	molecule	NOUN
ctmj-146	114	62	inhibitors	inhibitor	NOUN
ctmj-146	114	63	that	that	PRON
ctmj-146	114	64	specifically	specifically	ADV
ctmj-146	114	65	target	target	VERB
ctmj-146	114	66	cdc42	cdc42	NOUN
ctmj-146	114	67	-	-	PUNCT
ctmj-146	114	68	binding	bind	VERB
ctmj-146	114	69	mrck	mrck	NOUN
ctmj-146	114	70	kinases.63	kinases.63	PROPN
ctmj-146	114	71	examining	examine	VERB
ctmj-146	114	72	cvb	cvb	PROPN
ctmj-146	114	73	-	-	PUNCT
ctmj-146	114	74	d	d	PROPN
ctmj-146	114	75	's	's	PART
ctmj-146	114	76	action	action	NOUN
ctmj-146	114	77	on	on	ADP
ctmj-146	114	78	this	this	DET
ctmj-146	114	79	kinase	kinase	NOUN
ctmj-146	114	80	may	may	AUX
ctmj-146	114	81	provide	provide	VERB
ctmj-146	114	82	some	some	DET
ctmj-146	114	83	intriguing	intriguing	ADJ
ctmj-146	114	84	insights	insight	NOUN
ctmj-146	114	85	.	.	PUNCT
ctmj-146	115	1	there	there	PRON
ctmj-146	115	2	are	be	VERB
ctmj-146	115	3	likely	likely	ADJ
ctmj-146	115	4	several	several	ADJ
ctmj-146	115	5	targets	target	NOUN
ctmj-146	115	6	involved	involve	VERB
ctmj-146	115	7	in	in	ADP
ctmj-146	115	8	the	the	DET
ctmj-146	115	9	action	action	NOUN
ctmj-146	115	10	mechanism	mechanism	NOUN
ctmj-146	115	11	of	of	ADP
ctmj-146	115	12	cvb	cvb	PROPN
ctmj-146	115	13	-	-	PROPN
ctmj-146	115	14	d	d	PROPN
ctmj-146	115	15	,	,	PUNCT
ctmj-146	115	16	and	and	CCONJ
ctmj-146	115	17	it	it	PRON
ctmj-146	115	18	is	be	AUX
ctmj-146	115	19	challenging	challenge	VERB
ctmj-146	115	20	to	to	PART
ctmj-146	115	21	identify	identify	VERB
ctmj-146	115	22	the	the	DET
ctmj-146	115	23	target	target	NOUN
ctmj-146	115	24	of	of	ADP
ctmj-146	115	25	any	any	DET
ctmj-146	115	26	natural	natural	ADJ
ctmj-146	115	27	substance	substance	NOUN
ctmj-146	115	28	.	.	PUNCT
ctmj-146	116	1	the	the	DET
ctmj-146	116	2	related	related	ADJ
ctmj-146	116	3	cycloartane	cycloartane	NOUN
ctmj-146	116	4	actein	actein	PROPN
ctmj-146	116	5	(	(	PUNCT
ctmj-146	116	6	from	from	ADP
ctmj-146	116	7	the	the	DET
ctmj-146	116	8	medicinal	medicinal	ADJ
ctmj-146	116	9	plant	plant	NOUN
ctmj-146	116	10	cimicifuga	cimicifuga	PROPN
ctmj-146	116	11	racemosa	racemosa	PROPN
ctmj-146	116	12	)	)	PUNCT
ctmj-146	116	13	was	be	AUX
ctmj-146	116	14	used	use	VERB
ctmj-146	116	15	in	in	ADP
ctmj-146	116	16	a	a	DET
ctmj-146	116	17	recent	recent	ADJ
ctmj-146	116	18	targetfishing	targetfishe	VERB
ctmj-146	116	19	investigation	investigation	NOUN
ctmj-146	116	20	that	that	PRON
ctmj-146	116	21	used	use	VERB
ctmj-146	116	22	system	system	NOUN
ctmj-146	116	23	chemical	chemical	NOUN
ctmj-146	116	24	biology	biology	NOUN
ctmj-146	116	25	approaches	approach	VERB
ctmj-146	116	26	.	.	PUNCT
ctmj-146	117	1	the	the	DET
ctmj-146	117	2	analysis	analysis	NOUN
ctmj-146	117	3	revealed	reveal	VERB
ctmj-146	117	4	eight	eight	NUM
ctmj-146	117	5	possible	possible	ADJ
ctmj-146	117	6	targets	target	NOUN
ctmj-146	117	7	,	,	PUNCT
ctmj-146	117	8	one	one	NUM
ctmj-146	117	9	of	of	ADP
ctmj-146	117	10	which	which	PRON
ctmj-146	117	11	being	be	AUX
ctmj-146	117	12	the	the	DET
ctmj-146	117	13	metastasisassociated	metastasisassociate	VERB
ctmj-146	117	14	calcium	calcium	NOUN
ctmj-146	117	15	-	-	PUNCT
ctmj-146	117	16	binding	bind	VERB
ctmj-146	117	17	protein	protein	NOUN
ctmj-146	117	18	s100a4.64.65	s100a4.64.65	NOUN
ctmj-146	117	19	dollars	dollar	NOUN
ctmj-146	117	20	hepatocellular	hepatocellular	ADJ
ctmj-146	117	21	carcinoma66	carcinoma66	NOUN
ctmj-146	117	22	and	and	CCONJ
ctmj-146	117	23	colorectal	colorectal	ADJ
ctmj-146	117	24	cancers	cancer	NOUN
ctmj-146	117	25	associated	associate	VERB
ctmj-146	117	26	with	with	ADP
ctmj-146	117	27	herpes	herpe	NOUN
ctmj-146	117	28	simplex	simplex	NOUN
ctmj-146	117	29	virus	virus	NOUN
ctmj-146	117	30	have	have	AUX
ctmj-146	117	31	recently	recently	ADV
ctmj-146	117	32	had	have	AUX
ctmj-146	117	33	s100a4	s100a4	ADV
ctmj-146	117	34	suggested	suggest	VERB
ctmj-146	117	35	as	as	ADP
ctmj-146	117	36	a	a	DET
ctmj-146	117	37	potential	potential	ADJ
ctmj-146	117	38	therapeutic	therapeutic	ADJ
ctmj-146	117	39	target.67	target.67	NOUN
ctmj-146	117	40	,	,	PUNCT
ctmj-146	117	41	68	68	NUM
ctmj-146	117	42	specifically	specifically	ADV
ctmj-146	117	43	,	,	PUNCT
ctmj-146	117	44	s100a4	s100a4	ADJ
ctmj-146	117	45	controls	control	NOUN
ctmj-146	117	46	how	how	SCONJ
ctmj-146	117	47	polyploid	polyploid	ADJ
ctmj-146	117	48	large	large	ADJ
ctmj-146	117	49	cancer	cancer	NOUN
ctmj-146	117	50	cells	cell	NOUN
ctmj-146	117	51	migrate	migrate	VERB
ctmj-146	117	52	and	and	CCONJ
ctmj-146	117	53	invade.69	invade.69	NOUN
ctmj-146	117	54	cvb	cvb	PROPN
ctmj-146	117	55	-	-	PROPN
ctmj-146	117	56	d	d	PROPN
ctmj-146	117	57	has	have	AUX
ctmj-146	117	58	shown	show	VERB
ctmj-146	117	59	significant	significant	ADJ
ctmj-146	117	60	action	action	NOUN
ctmj-146	117	61	in	in	ADP
ctmj-146	117	62	vivo	vivo	NOUN
ctmj-146	117	63	models	model	NOUN
ctmj-146	117	64	of	of	ADP
ctmj-146	117	65	hcc	hcc	PROPN
ctmj-146	117	66	and	and	CCONJ
ctmj-146	117	67	colon	colon	NOUN
ctmj-146	117	68	cancer	cancer	NOUN
ctmj-146	117	69	,	,	PUNCT
ctmj-146	117	70	as	as	SCONJ
ctmj-146	117	71	previously	previously	ADV
ctmj-146	117	72	mentioned	mention	VERB
ctmj-146	117	73	.	.	PUNCT
ctmj-146	118	1	hence	hence	ADV
ctmj-146	118	2	,	,	PUNCT
ctmj-146	118	3	research	research	NOUN
ctmj-146	118	4	into	into	ADP
ctmj-146	118	5	the	the	DET
ctmj-146	118	6	possibility	possibility	NOUN
ctmj-146	118	7	of	of	ADP
ctmj-146	118	8	cvb	cvb	PROPN
ctmj-146	118	9	-	-	PUNCT
ctmj-146	118	10	d	d	PROPN
ctmj-146	118	11	binding	bind	VERB
ctmj-146	118	12	to	to	ADP
ctmj-146	118	13	s100a4	s100a4	ADJ
ctmj-146	118	14	is	be	AUX
ctmj-146	118	15	warranted	warrant	VERB
ctmj-146	118	16	.	.	PUNCT
ctmj-146	119	1	although	although	SCONJ
ctmj-146	119	2	they	they	PRON
ctmj-146	119	3	share	share	VERB
ctmj-146	119	4	some	some	DET
ctmj-146	119	5	structural	structural	ADJ
ctmj-146	119	6	features	feature	NOUN
ctmj-146	119	7	,	,	PUNCT
ctmj-146	119	8	the	the	DET
ctmj-146	119	9	glycosylated	glycosylated	ADJ
ctmj-146	119	10	cycloartane	cycloartane	NOUN
ctmj-146	119	11	actein	actein	ADV
ctmj-146	119	12	is	be	AUX
ctmj-146	119	13	structurally	structurally	ADV
ctmj-146	119	14	different	different	ADJ
ctmj-146	119	15	from	from	ADP
ctmj-146	119	16	cvb	cvb	PROPN
ctmj-146	119	17	-	-	PUNCT
ctmj-146	119	18	d	d	PROPN
ctmj-146	119	19	(	(	PUNCT
ctmj-146	119	20	fig	fig	NOUN
ctmj-146	119	21	.	.	PUNCT
ctmj-146	120	1	2	2	NUM
ctmj-146	120	2	)	)	PUNCT
ctmj-146	120	3	.	.	PUNCT
ctmj-146	121	1	we	we	PRON
ctmj-146	121	2	should	should	AUX
ctmj-146	121	3	expect	expect	VERB
ctmj-146	121	4	a	a	DET
ctmj-146	121	5	comparable	comparable	ADJ
ctmj-146	121	6	level	level	NOUN
ctmj-146	121	7	of	of	ADP
ctmj-146	121	8	mechanical	mechanical	ADJ
ctmj-146	121	9	complexity	complexity	NOUN
ctmj-146	121	10	,	,	PUNCT
ctmj-146	121	11	with	with	ADP
ctmj-146	121	12	several	several	ADJ
ctmj-146	121	13	goals	goal	NOUN
ctmj-146	121	14	contributing	contribute	VERB
ctmj-146	121	15	to	to	ADP
ctmj-146	121	16	it	it	PRON
ctmj-146	121	17	.	.	PUNCT
ctmj-146	122	1	figure	figure	VERB
ctmj-146	122	2	3	3	NUM
ctmj-146	122	3	shows	show	VERB
ctmj-146	122	4	a	a	DET
ctmj-146	122	5	schematic	schematic	ADJ
ctmj-146	122	6	of	of	ADP
ctmj-146	122	7	the	the	DET
ctmj-146	122	8	mechanism	mechanism	NOUN
ctmj-146	122	9	of	of	ADP
ctmj-146	122	10	action	action	NOUN
ctmj-146	122	11	of	of	ADP
ctmj-146	122	12	cyclovirobuxine	cyclovirobuxine	PROPN
ctmj-146	122	13	d	d	PROPN
ctmj-146	122	14	(	(	PUNCT
ctmj-146	122	15	cvb	cvb	PROPN
ctmj-146	122	16	-	-	PROPN
ctmj-146	122	17	d	d	NOUN
ctmj-146	122	18	)	)	PUNCT
ctmj-146	122	19	.	.	PUNCT
ctmj-146	123	1	several	several	ADJ
ctmj-146	123	2	proteins	protein	NOUN
ctmj-146	123	3	,	,	PUNCT
ctmj-146	123	4	including	include	VERB
ctmj-146	123	5	as	as	ADP
ctmj-146	123	6	erk1/2	erk1/2	PROPN
ctmj-146	123	7	,	,	PUNCT
ctmj-146	123	8	egfr	egfr	NOUN
ctmj-146	123	9	,	,	PUNCT
ctmj-146	123	10	mtor	mtor	NOUN
ctmj-146	123	11	,	,	PUNCT
ctmj-146	123	12	and	and	CCONJ
ctmj-146	123	13	akt	akt	PROPN
ctmj-146	123	14	,	,	PUNCT
ctmj-146	123	15	are	be	AUX
ctmj-146	123	16	phosphorylated	phosphorylate	VERB
ctmj-146	123	17	when	when	SCONJ
ctmj-146	123	18	exposed	expose	VERB
ctmj-146	123	19	to	to	ADP
ctmj-146	123	20	cvb	cvb	PROPN
ctmj-146	123	21	-	-	PROPN
ctmj-146	123	22	d.	d.	PROPN
ctmj-146	123	23	because	because	SCONJ
ctmj-146	123	24	of	of	ADP
ctmj-146	123	25	these	these	DET
ctmj-146	123	26	consequences	consequence	NOUN
ctmj-146	123	27	,	,	PUNCT
ctmj-146	123	28	mitochondrial	mitochondrial	ADJ
ctmj-146	123	29	disturbances	disturbance	NOUN
ctmj-146	123	30	trigger	trigger	VERB
ctmj-146	123	31	the	the	DET
ctmj-146	123	32	intrinsic	intrinsic	ADJ
ctmj-146	123	33	apoptotic	apoptotic	ADJ
ctmj-146	123	34	pathway	pathway	NOUN
ctmj-146	123	35	.	.	PUNCT
ctmj-146	124	1	additionally	additionally	ADV
ctmj-146	124	2	,	,	PUNCT
ctmj-146	124	3	it	it	PRON
ctmj-146	124	4	triggers	trigger	VERB
ctmj-146	124	5	the	the	DET
ctmj-146	124	6	transcription	transcription	NOUN
ctmj-146	124	7	of	of	ADP
ctmj-146	124	8	genes	gene	NOUN
ctmj-146	124	9	that	that	PRON
ctmj-146	124	10	play	play	VERB
ctmj-146	124	11	a	a	DET
ctmj-146	124	12	role	role	NOUN
ctmj-146	124	13	in	in	ADP
ctmj-146	124	14	regulating	regulate	VERB
ctmj-146	124	15	the	the	DET
ctmj-146	124	16	cell	cell	NOUN
ctmj-146	124	17	cycle	cycle	NOUN
ctmj-146	124	18	and	and	CCONJ
ctmj-146	124	19	promoting	promote	VERB
ctmj-146	124	20	cell	cell	NOUN
ctmj-146	124	21	proliferation	proliferation	NOUN
ctmj-146	124	22	.	.	PUNCT
ctmj-146	125	1	cvb	cvb	PROPN
ctmj-146	125	2	-	-	PUNCT
ctmj-146	125	3	d	d	PROPN
ctmj-146	125	4	also	also	ADV
ctmj-146	125	5	inhibits	inhibit	VERB
ctmj-146	125	6	the	the	DET
ctmj-146	125	7	akt	akt	PROPN
ctmj-146	125	8	/	/	SYM
ctmj-146	125	9	mtor	mtor	PROPN
ctmj-146	125	10	axis	axis	NOUN
ctmj-146	125	11	,	,	PUNCT
ctmj-146	125	12	which	which	PRON
ctmj-146	125	13	allows	allow	VERB
ctmj-146	125	14	certain	certain	ADJ
ctmj-146	125	15	cancer	cancer	NOUN
ctmj-146	125	16	cells	cell	NOUN
ctmj-146	125	17	to	to	PART
ctmj-146	125	18	initiate	initiate	VERB
ctmj-146	125	19	autophagy	autophagy	NOUN
ctmj-146	125	20	.	.	PUNCT
ctmj-146	126	1	currently	currently	ADV
ctmj-146	126	2	,	,	PUNCT
ctmj-146	126	3	cvbd	cvbd	PROPN
ctmj-146	126	4	's	's	PART
ctmj-146	126	5	upstream	upstream	ADJ
ctmj-146	126	6	targets	target	NOUN
ctmj-146	126	7	remain	remain	VERB
ctmj-146	126	8	a	a	DET
ctmj-146	126	9	mystery	mystery	NOUN
ctmj-146	126	10	;	;	PUNCT
ctmj-146	126	11	nevertheless	nevertheless	ADV
ctmj-146	126	12	,	,	PUNCT
ctmj-146	126	13	there	there	PRON
ctmj-146	126	14	is	be	VERB
ctmj-146	126	15	talk	talk	NOUN
ctmj-146	126	16	of	of	ADP
ctmj-146	126	17	a	a	DET
ctmj-146	126	18	possible	possible	ADJ
ctmj-146	126	19	direct	direct	ADJ
ctmj-146	126	20	effect	effect	NOUN
ctmj-146	126	21	on	on	ADP
ctmj-146	126	22	egfr	egfr	NOUN
ctmj-146	126	23	as	as	ADV
ctmj-146	126	24	well	well	ADV
ctmj-146	126	25	as	as	ADP
ctmj-146	126	26	the	the	DET
ctmj-146	126	27	proteins	protein	NOUN
ctmj-146	126	28	s100a4	s100a4	ADJ
ctmj-146	126	29	and	and	CCONJ
ctmj-146	126	30	cthrc1	cthrc1	NOUN
ctmj-146	126	31	.	.	PUNCT
ctmj-146	127	1	anti	anti	ADJ
ctmj-146	127	2	-	-	ADJ
ctmj-146	127	3	cancer	cancer	ADJ
ctmj-146	127	4	effects	effect	NOUN
ctmj-146	127	5	.	.	PUNCT
ctmj-146	128	1	since	since	SCONJ
ctmj-146	128	2	s100a4	s100a4	ADJ
ctmj-146	128	3	is	be	AUX
ctmj-146	128	4	an	an	DET
ctmj-146	128	5	essential	essential	ADJ
ctmj-146	128	6	ligand	ligand	NOUN
ctmj-146	128	7	of	of	ADP
ctmj-146	128	8	the	the	DET
ctmj-146	128	9	egfr	egfr	ADJ
ctmj-146	128	10	receptor	receptor	NOUN
ctmj-146	128	11	,	,	PUNCT
ctmj-146	128	12	an	an	DET
ctmj-146	128	13	interaction	interaction	NOUN
ctmj-146	128	14	between	between	ADP
ctmj-146	128	15	cvb	cvb	PROPN
ctmj-146	128	16	-	-	PUNCT
ctmj-146	128	17	d	d	PROPN
ctmj-146	128	18	and	and	CCONJ
ctmj-146	128	19	s100a4	s100a4	PROPN
ctmj-146	128	20	may	may	AUX
ctmj-146	128	21	account	account	VERB
ctmj-146	128	22	for	for	ADP
ctmj-146	128	23	the	the	DET
ctmj-146	128	24	drug	drug	NOUN
ctmj-146	128	25	's	's	PART
ctmj-146	128	26	subsequent	subsequent	ADJ
ctmj-146	128	27	effects	effect	NOUN
ctmj-146	128	28	,	,	PUNCT
ctmj-146	128	29	most	most	ADV
ctmj-146	128	30	noticeably	noticeably	ADV
ctmj-146	128	31	the	the	DET
ctmj-146	128	32	drug	drug	NOUN
ctmj-146	128	33	-	-	PUNCT
ctmj-146	128	34	induced	induce	VERB
ctmj-146	128	35	suppression	suppression	NOUN
ctmj-146	128	36	of	of	ADP
ctmj-146	128	37	egfr	egfr	ADJ
ctmj-146	128	38	phosphorylation	phosphorylation	NOUN
ctmj-146	128	39	seen	see	VERB
ctmj-146	128	40	in	in	ADP
ctmj-146	128	41	vitro.70	vitro.70	PROPN
ctmj-146	128	42	,	,	PUNCT
ctmj-146	128	43	71	71	NUM
ctmj-146	128	44	the	the	DET
ctmj-146	128	45	function	function	NOUN
ctmj-146	128	46	of	of	ADP
ctmj-146	128	47	s100a4	s100a4	ADJ
ctmj-146	128	48	in	in	ADP
ctmj-146	128	49	cancer	cancer	NOUN
ctmj-146	128	50	metastasis72	metastasis72	NOUN
ctmj-146	128	51	has	have	AUX
ctmj-146	128	52	been	be	AUX
ctmj-146	128	53	shown	show	VERB
ctmj-146	128	54	,	,	PUNCT
ctmj-146	128	55	and	and	CCONJ
ctmj-146	128	56	a	a	DET
ctmj-146	128	57	small	small	ADJ
ctmj-146	128	58	polyaromatic	polyaromatic	ADJ
ctmj-146	128	59	compound	compound	NOUN
ctmj-146	128	60	called	call	VERB
ctmj-146	128	61	amlexanox	amlexanox	NOUN
ctmj-146	128	62	has	have	AUX
ctmj-146	128	63	been	be	AUX
ctmj-146	128	64	found	find	VERB
ctmj-146	128	65	to	to	PART
ctmj-146	128	66	suppress	suppress	VERB
ctmj-146	128	67	cancer	cancer	NOUN
ctmj-146	128	68	cell	cell	NOUN
ctmj-146	128	69	proliferation	proliferation	NOUN
ctmj-146	128	70	by	by	ADP
ctmj-146	128	71	disrupting	disrupt	VERB
ctmj-146	128	72	the	the	DET
ctmj-146	128	73	interaction	interaction	NOUN
ctmj-146	128	74	between	between	ADP
ctmj-146	128	75	s100a4	s100a4	NOUN
ctmj-146	128	76	and	and	CCONJ
ctmj-146	128	77	egf.73	egf.73	NOUN
ctmj-146	128	78	in	in	ADP
ctmj-146	128	79	addition	addition	NOUN
ctmj-146	128	80	,	,	PUNCT
ctmj-146	128	81	part	part	NOUN
ctmj-146	128	82	of	of	ADP
ctmj-146	128	83	the	the	DET
ctmj-146	128	84	p53dependent	p53dependent	PROPN
ctmj-146	128	85	effects	effect	NOUN
ctmj-146	128	86	shown	show	VERB
ctmj-146	128	87	with	with	ADP
ctmj-146	128	88	cvb	cvb	PROPN
ctmj-146	128	89	-	-	PUNCT
ctmj-146	128	90	d	d	NOUN
ctmj-146	128	91	may	may	AUX
ctmj-146	128	92	be	be	AUX
ctmj-146	128	93	explained	explain	VERB
ctmj-146	128	94	by	by	ADP
ctmj-146	128	95	the	the	DET
ctmj-146	128	96	fact	fact	NOUN
ctmj-146	128	97	that	that	SCONJ
ctmj-146	128	98	s100a4	s100a4	ADJ
ctmj-146	128	99	forms	form	NOUN
ctmj-146	128	100	complexes	complexe	VERB
ctmj-146	128	101	with	with	ADP
ctmj-146	128	102	p53,74	p53,74	PROPN
ctmj-146	128	103	.	.	PUNCT
ctmj-146	129	1	therefore	therefore	ADV
ctmj-146	129	2	,	,	PUNCT
ctmj-146	129	3	we	we	PRON
ctmj-146	129	4	suggest	suggest	AUX
ctmj-146	129	5	looking	look	VERB
ctmj-146	129	6	into	into	ADP
ctmj-146	129	7	the	the	DET
ctmj-146	129	8	possibility	possibility	NOUN
ctmj-146	129	9	of	of	ADP
ctmj-146	129	10	cvb	cvb	PROPN
ctmj-146	129	11	-	-	PROPN
ctmj-146	129	12	d	d	NOUN
ctmj-146	129	13	interacting	interact	VERB
ctmj-146	129	14	with	with	ADP
ctmj-146	129	15	s100a4	s100a4	ADJ
ctmj-146	129	16	and	and	CCONJ
ctmj-146	129	17	the	the	DET
ctmj-146	129	18	consequent	consequent	ADJ
ctmj-146	129	19	egfr	egfr	NOUN
ctmj-146	129	20	antagonist	antagonist	NOUN
ctmj-146	129	21	effect	effect	NOUN
ctmj-146	129	22	.	.	PUNCT
ctmj-146	130	1	additionally	additionally	ADV
ctmj-146	130	2	,	,	PUNCT
ctmj-146	130	3	it	it	PRON
ctmj-146	130	4	would	would	AUX
ctmj-146	130	5	be	be	AUX
ctmj-146	130	6	beneficial	beneficial	ADJ
ctmj-146	130	7	to	to	PART
ctmj-146	130	8	study	study	VERB
ctmj-146	130	9	how	how	SCONJ
ctmj-146	130	10	cvb	cvb	VERB
ctmj-146	130	11	-	-	PROPN
ctmj-146	130	12	d	d	NOUN
ctmj-146	130	13	may	may	AUX
ctmj-146	130	14	interact	interact	VERB
ctmj-146	130	15	with	with	ADP
ctmj-146	130	16	egfr	egfr	NOUN
ctmj-146	130	17	,	,	PUNCT
ctmj-146	130	18	since	since	SCONJ
ctmj-146	130	19	this	this	DET
ctmj-146	130	20	receptor	receptor	NOUN
ctmj-146	130	21	has	have	AUX
ctmj-146	130	22	been	be	AUX
ctmj-146	130	23	shown	show	VERB
ctmj-146	130	24	to	to	PART
ctmj-146	130	25	be	be	AUX
ctmj-146	130	26	directly	directly	ADV
ctmj-146	130	27	occupied	occupy	VERB
ctmj-146	130	28	by	by	ADP
ctmj-146	130	29	a	a	DET
ctmj-146	130	30	number	number	NOUN
ctmj-146	130	31	of	of	ADP
ctmj-146	130	32	natural	natural	ADJ
ctmj-146	130	33	products	product	NOUN
ctmj-146	130	34	that	that	PRON
ctmj-146	130	35	inhibit	inhibit	VERB
ctmj-146	130	36	egf	egf	PROPN
ctmj-146	130	37	binding	bind	VERB
ctmj-146	130	38	to	to	ADP
ctmj-146	130	39	egfr	egfr	VERB
ctmj-146	130	40	,	,	PUNCT
ctmj-146	130	41	such	such	ADJ
ctmj-146	130	42	as	as	ADP
ctmj-146	130	43	cucurbitacin	cucurbitacin	PROPN
ctmj-146	130	44	d	d	NOUN
ctmj-146	130	45	and	and	CCONJ
ctmj-146	130	46	analogs	analog	NOUN
ctmj-146	130	47	,	,	PUNCT
ctmj-146	130	48	and	and	CCONJ
ctmj-146	130	49	protopanaxadiol.from	protopanaxadiol.from	ADP
ctmj-146	130	50	75	75	NUM
ctmj-146	130	51	to	to	PART
ctmj-146	130	52	78	78	NUM
ctmj-146	130	53	in	in	ADP
ctmj-146	130	54	conclusion	conclusion	NOUN
ctmj-146	130	55	,	,	PUNCT
ctmj-146	130	56	it	it	PRON
ctmj-146	130	57	has	have	AUX
ctmj-146	130	58	been	be	AUX
ctmj-146	130	59	shown	show	VERB
ctmj-146	130	60	after	after	ADP
ctmj-146	130	61	a	a	DET
ctmj-146	130	62	thorough	thorough	ADJ
ctmj-146	130	63	literature	literature	NOUN
ctmj-146	130	64	review	review	NOUN
ctmj-146	130	65	that	that	SCONJ
ctmj-146	130	66	proteins	protein	VERB
ctmj-146	130	67	cthrc1	cthrc1	NOUN
ctmj-146	130	68	,	,	PUNCT
ctmj-146	130	69	s100a4	s100a4	ADJ
ctmj-146	130	70	,	,	PUNCT
ctmj-146	130	71	and	and	CCONJ
ctmj-146	130	72	egfr	egfr	NOUN
ctmj-146	130	73	are	be	AUX
ctmj-146	130	74	the	the	DET
ctmj-146	130	75	three	three	NUM
ctmj-146	130	76	most	most	ADV
ctmj-146	130	77	promising	promising	ADJ
ctmj-146	130	78	anticancer	anticancer	NOUN
ctmj-146	130	79	target	target	NOUN
ctmj-146	130	80	candidates	candidate	NOUN
ctmj-146	130	81	for	for	ADP
ctmj-146	130	82	cvb	cvb	PROPN
ctmj-146	130	83	-	-	PROPN
ctmj-146	130	84	d	d	PROPN
ctmj-146	130	85	(	(	PUNCT
ctmj-146	130	86	fig	fig	NOUN
ctmj-146	130	87	.	.	PUNCT
ctmj-146	131	1	3	3	NUM
ctmj-146	131	2	)	)	PUNCT
ctmj-146	131	3	.	.	PUNCT
ctmj-146	132	1	naturally	naturally	ADV
ctmj-146	132	2	,	,	PUNCT
ctmj-146	132	3	there	there	PRON
ctmj-146	132	4	can	can	AUX
ctmj-146	132	5	be	be	AUX
ctmj-146	132	6	other	other	ADJ
ctmj-146	132	7	ones	one	NOUN
ctmj-146	132	8	.	.	PUNCT
ctmj-146	133	1	to	to	PART
ctmj-146	133	2	find	find	VERB
ctmj-146	133	3	other	other	ADJ
ctmj-146	133	4	proteins	protein	NOUN
ctmj-146	133	5	that	that	PRON
ctmj-146	133	6	cvb	cvb	PROPN
ctmj-146	133	7	-	-	PROPN
ctmj-146	133	8	d	d	PROPN
ctmj-146	133	9	can	can	AUX
ctmj-146	133	10	target	target	VERB
ctmj-146	133	11	,	,	PUNCT
ctmj-146	133	12	it	it	PRON
ctmj-146	133	13	might	might	AUX
ctmj-146	133	14	be	be	AUX
ctmj-146	133	15	helpful	helpful	ADJ
ctmj-146	133	16	to	to	PART
ctmj-146	133	17	use	use	VERB
ctmj-146	133	18	reverse	reverse	NOUN
ctmj-146	133	19	screening	screen	VERB
ctmj-146	133	20	methods79,80	methods79,80	NOUN
ctmj-146	133	21	.	.	PUNCT
ctmj-146	134	1	however	however	ADV
ctmj-146	134	2	,	,	PUNCT
ctmj-146	134	3	it	it	PRON
ctmj-146	134	4	may	may	AUX
ctmj-146	134	5	result	result	VERB
ctmj-146	134	6	in	in	ADP
ctmj-146	134	7	a	a	DET
ctmj-146	134	8	large	large	ADJ
ctmj-146	134	9	number	number	NOUN
ctmj-146	134	10	of	of	ADP
ctmj-146	134	11	contenders	contender	NOUN
ctmj-146	134	12	.	.	PUNCT
ctmj-146	135	1	to	to	PART
ctmj-146	135	2	illustrate	illustrate	VERB
ctmj-146	135	3	the	the	DET
ctmj-146	135	4	point	point	NOUN
ctmj-146	135	5	,	,	PUNCT
ctmj-146	135	6	twelve	twelve	NUM
ctmj-146	135	7	signal	signal	NOUN
ctmj-146	135	8	transduction	transduction	NOUN
ctmj-146	135	9	pathways	pathway	NOUN
ctmj-146	135	10	and	and	CCONJ
ctmj-146	135	11	thirty	thirty	NUM
ctmj-146	135	12	-	-	PUNCT
ctmj-146	135	13	three	three	NUM
ctmj-146	135	14	critical	critical	ADJ
ctmj-146	135	15	target	target	NOUN
ctmj-146	135	16	proteins	protein	NOUN
ctmj-146	135	17	were	be	AUX
ctmj-146	135	18	uncovered	uncover	VERB
ctmj-146	135	19	when	when	SCONJ
ctmj-146	135	20	the	the	DET
ctmj-146	135	21	anticancer	anticancer	NOUN
ctmj-146	135	22	medicine	medicine	NOUN
ctmj-146	135	23	epigallocatechin-3gallate	epigallocatechin-3gallate	PROPN
ctmj-146	135	24	's	's	PART
ctmj-146	135	25	potential	potential	ADJ
ctmj-146	135	26	targets	target	NOUN
ctmj-146	135	27	were	be	AUX
ctmj-146	135	28	identified	identify	VERB
ctmj-146	135	29	using	use	VERB
ctmj-146	135	30	a	a	DET
ctmj-146	135	31	reverse	reverse	ADJ
ctmj-146	135	32	docking	docking	NOUN
ctmj-146	135	33	approach.81	approach.81	NOUN
ctmj-146	135	34	conclusion	conclusion	NOUN
ctmj-146	135	35	and	and	CCONJ
ctmj-146	135	36	prospects	prospect	NOUN
ctmj-146	135	37	historically	historically	ADV
ctmj-146	135	38	,	,	PUNCT
ctmj-146	135	39	cyclovirobuxine	cyclovirobuxine	PROPN
ctmj-146	135	40	d	d	PROPN
ctmj-146	135	41	,	,	PUNCT
ctmj-146	135	42	a	a	DET
ctmj-146	135	43	triterpenoid	triterpenoid	NOUN
ctmj-146	135	44	alkaloid	alkaloid	NOUN
ctmj-146	135	45	,	,	PUNCT
ctmj-146	135	46	has	have	AUX
ctmj-146	135	47	been	be	AUX
ctmj-146	135	48	used	use	VERB
ctmj-146	135	49	to	to	PART
ctmj-146	135	50	treat	treat	VERB
ctmj-146	135	51	cardiovascular	cardiovascular	ADJ
ctmj-146	135	52	diseases	disease	NOUN
ctmj-146	135	53	in	in	ADP
ctmj-146	135	54	traditional	traditional	ADJ
ctmj-146	135	55	chinese	chinese	ADJ
ctmj-146	135	56	medicine	medicine	NOUN
ctmj-146	135	57	.	.	PUNCT
ctmj-146	136	1	the	the	DET
ctmj-146	136	2	antiarrhythmia	antiarrhythmia	ADJ
ctmj-146	136	3	and	and	CCONJ
ctmj-146	136	4	vasodilatory	vasodilatory	ADJ
ctmj-146	136	5	actions	action	NOUN
ctmj-146	136	6	of	of	ADP
ctmj-146	136	7	the	the	DET
ctmj-146	136	8	medicine	medicine	NOUN
ctmj-146	136	9	huangyangning	huangyangne	VERB
ctmj-146	136	10	have	have	AUX
ctmj-146	136	11	made	make	VERB
ctmj-146	136	12	it	it	PRON
ctmj-146	136	13	famous	famous	ADJ
ctmj-146	136	14	.	.	PUNCT
ctmj-146	137	1	no	no	DET
ctmj-146	137	2	organ	organ	NOUN
ctmj-146	137	3	damage	damage	NOUN
ctmj-146	137	4	or	or	CCONJ
ctmj-146	137	5	general	general	ADJ
ctmj-146	137	6	toxicity	toxicity	NOUN
ctmj-146	137	7	was	be	AUX
ctmj-146	137	8	seen	see	VERB
ctmj-146	137	9	in	in	ADP
ctmj-146	137	10	rats	rat	NOUN
ctmj-146	137	11	fed	feed	VERB
ctmj-146	137	12	for	for	ADP
ctmj-146	137	13	eight	eight	NUM
ctmj-146	137	14	weeks	week	NOUN
ctmj-146	137	15	continuously	continuously	ADV
ctmj-146	137	16	with	with	ADP
ctmj-146	137	17	a	a	DET
ctmj-146	137	18	dose	dose	ADJ
ctmj-146	137	19	50	50	NUM
ctmj-146	137	20	-	-	PUNCT
ctmj-146	137	21	to200	to200	PROPN
ctmj-146	137	22	times	time	NOUN
ctmj-146	137	23	higher	high	ADJ
ctmj-146	137	24	than	than	ADP
ctmj-146	137	25	the	the	DET
ctmj-146	137	26	human	human	ADJ
ctmj-146	137	27	dosage	dosage	NOUN
ctmj-146	137	28	,	,	PUNCT
ctmj-146	137	29	according	accord	VERB
ctmj-146	137	30	to	to	ADP
ctmj-146	137	31	a	a	DET
ctmj-146	137	32	recent	recent	ADJ
ctmj-146	137	33	toxicology	toxicology	NOUN
ctmj-146	137	34	research.18	research.18	NOUN
ctmj-146	137	35	despite	despite	SCONJ
ctmj-146	137	36	the	the	DET
ctmj-146	137	37	lack	lack	NOUN
ctmj-146	137	38	of	of	ADP
ctmj-146	137	39	published	publish	VERB
ctmj-146	137	40	clinical	clinical	ADJ
ctmj-146	137	41	research	research	NOUN
ctmj-146	137	42	supporting	support	VERB
ctmj-146	137	43	the	the	DET
ctmj-146	137	44	charges	charge	NOUN
ctmj-146	137	45	,	,	PUNCT
ctmj-146	137	46	the	the	DET
ctmj-146	137	47	medicine	medicine	NOUN
ctmj-146	137	48	seems	seem	VERB
ctmj-146	137	49	to	to	PART
ctmj-146	137	50	be	be	AUX
ctmj-146	137	51	safe	safe	ADJ
ctmj-146	137	52	and	and	CCONJ
ctmj-146	137	53	effective	effective	ADJ
ctmj-146	137	54	,	,	PUNCT
ctmj-146	137	55	and	and	CCONJ
ctmj-146	137	56	it	it	PRON
ctmj-146	137	57	has	have	AUX
ctmj-146	137	58	been	be	AUX
ctmj-146	137	59	seen	see	VERB
ctmj-146	137	60	in	in	ADP
ctmj-146	137	61	chinese	chinese	ADJ
ctmj-146	137	62	hospitals	hospital	NOUN
ctmj-146	137	63	for	for	ADP
ctmj-146	137	64	decades	decade	NOUN
ctmj-146	137	65	.	.	PUNCT
ctmj-146	138	1	but	but	CCONJ
ctmj-146	138	2	the	the	DET
ctmj-146	138	3	huangyangning	huangyangning	NOUN
ctmj-146	138	4	pills	pill	NOUN
ctmj-146	138	5	'	'	PART
ctmj-146	138	6	active	active	ADJ
ctmj-146	138	7	pharmaceutical	pharmaceutical	ADJ
ctmj-146	138	8	ingredient	ingredient	NOUN
ctmj-146	138	9	(	(	PUNCT
ctmj-146	138	10	api	api	NOUN
ctmj-146	138	11	)	)	PUNCT
ctmj-146	138	12	,	,	PUNCT
ctmj-146	138	13	cyclovirobuxine	cyclovirobuxine	PROPN
ctmj-146	138	14	d	d	PROPN
ctmj-146	138	15	,	,	PUNCT
ctmj-146	138	16	has	have	VERB
ctmj-146	138	17	a	a	DET
ctmj-146	138	18	history	history	NOUN
ctmj-146	138	19	of	of	ADP
ctmj-146	138	20	use	use	NOUN
ctmj-146	138	21	in	in	ADP
ctmj-146	138	22	the	the	DET
ctmj-146	138	23	treatment	treatment	NOUN
ctmj-146	138	24	of	of	ADP
ctmj-146	138	25	cardiovascular	cardiovascular	ADJ
ctmj-146	138	26	disorders	disorder	NOUN
ctmj-146	138	27	.	.	PUNCT
ctmj-146	139	1	since	since	SCONJ
ctmj-146	139	2	2009	2009	NUM
ctmj-146	139	3	,	,	PUNCT
ctmj-146	139	4	the	the	DET
ctmj-146	139	5	cfda	cfda	PROPN
ctmj-146	139	6	has	have	AUX
ctmj-146	139	7	authorized	authorize	VERB
ctmj-146	139	8	the	the	DET
ctmj-146	139	9	medicine	medicine	NOUN
ctmj-146	139	10	,	,	PUNCT
ctmj-146	139	11	and	and	CCONJ
ctmj-146	139	12	many	many	ADJ
ctmj-146	139	13	pharmaceutical	pharmaceutical	ADJ
ctmj-146	139	14	firms	firm	NOUN
ctmj-146	139	15	offer	offer	VERB
ctmj-146	139	16	the	the	DET
ctmj-146	139	17	active	active	ADJ
ctmj-146	139	18	pharmaceutical	pharmaceutical	ADJ
ctmj-146	139	19	ingredient	ingredient	NOUN
ctmj-146	139	20	(	(	PUNCT
ctmj-146	139	21	api	api	NOUN
ctmj-146	139	22	)	)	PUNCT
ctmj-146	139	23	.	.	PUNCT
ctmj-146	140	1	to	to	PART
ctmj-146	140	2	speed	speed	VERB
ctmj-146	140	3	up	up	ADP
ctmj-146	140	4	the	the	DET
ctmj-146	140	5	drug	drug	NOUN
ctmj-146	140	6	's	's	PART
ctmj-146	140	7	dissolving	dissolve	VERB
ctmj-146	140	8	rate	rate	NOUN
ctmj-146	140	9	,	,	PUNCT
ctmj-146	140	10	researchers	researcher	NOUN
ctmj-146	140	11	are	be	AUX
ctmj-146	140	12	creating	create	VERB
ctmj-146	140	13	new	new	ADJ
ctmj-146	140	14	cvb	cvb	PROPN
ctmj-146	140	15	-	-	PUNCT
ctmj-146	140	16	d	d	PROPN
ctmj-146	140	17	formulations	formulation	NOUN
ctmj-146	140	18	including	include	VERB
ctmj-146	140	19	cvb	cvb	PROPN
ctmj-146	140	20	-	-	PROPN
ctmj-146	140	21	d	d	PROPN
ctmj-146	140	22	nanosuspensions.82	nanosuspensions.82	PROPN
ctmj-146	140	23	cvb	cvb	PROPN
ctmj-146	140	24	-	-	PROPN
ctmj-146	140	25	d	d	PROPN
ctmj-146	140	26	has	have	AUX
ctmj-146	140	27	recently	recently	ADV
ctmj-146	140	28	opened	open	VERB
ctmj-146	140	29	up	up	ADP
ctmj-146	140	30	new	new	ADJ
ctmj-146	140	31	avenues	avenue	NOUN
ctmj-146	140	32	of	of	ADP
ctmj-146	140	33	potential	potential	ADJ
ctmj-146	140	34	use	use	NOUN
ctmj-146	140	35	outside	outside	ADP
ctmj-146	140	36	the	the	DET
ctmj-146	140	37	cardiovascular	cardiovascular	ADJ
ctmj-146	140	38	sector	sector	NOUN
ctmj-146	140	39	,	,	PUNCT
ctmj-146	140	40	namely	namely	ADV
ctmj-146	140	41	in	in	ADP
ctmj-146	140	42	the	the	DET
ctmj-146	140	43	fight	fight	NOUN
ctmj-146	140	44	against	against	ADP
ctmj-146	140	45	cancer	cancer	NOUN
ctmj-146	140	46	.	.	PUNCT
ctmj-146	141	1	preliminary	preliminary	ADJ
ctmj-146	141	2	evidence	evidence	NOUN
ctmj-146	141	3	of	of	ADP
ctmj-146	141	4	activity	activity	NOUN
ctmj-146	141	5	in	in	ADP
ctmj-146	141	6	vivo	vivo	NOUN
ctmj-146	141	7	has	have	AUX
ctmj-146	141	8	been	be	AUX
ctmj-146	141	9	reported	report	VERB
ctmj-146	141	10	lately	lately	ADV
ctmj-146	141	11	,	,	PUNCT
ctmj-146	141	12	and	and	CCONJ
ctmj-146	141	13	other	other	ADJ
ctmj-146	141	14	investigations	investigation	NOUN
ctmj-146	141	15	have	have	AUX
ctmj-146	141	16	shown	show	VERB
ctmj-146	141	17	that	that	SCONJ
ctmj-146	141	18	the	the	DET
ctmj-146	141	19	medication	medication	NOUN
ctmj-146	141	20	has	have	VERB
ctmj-146	141	21	antiproliferative	antiproliferative	ADJ
ctmj-146	141	22	effects	effect	NOUN
ctmj-146	141	23	against	against	ADP
ctmj-146	141	24	various	various	ADJ
ctmj-146	141	25	cancer	cancer	NOUN
ctmj-146	141	26	cell	cell	NOUN
ctmj-146	141	27	types	type	NOUN
ctmj-146	141	28	in	in	ADP
ctmj-146	141	29	vitro	vitro	VERB
ctmj-146	141	30	.	.	PUNCT
ctmj-146	142	1	though	though	SCONJ
ctmj-146	142	2	the	the	DET
ctmj-146	142	3	activity	activity	NOUN
ctmj-146	142	4	level	level	NOUN
ctmj-146	142	5	is	be	AUX
ctmj-146	142	6	n't	not	PART
ctmj-146	142	7	very	very	ADV
ctmj-146	142	8	high	high	ADJ
ctmj-146	142	9	,	,	PUNCT
ctmj-146	142	10	the	the	DET
ctmj-146	142	11	antitumor	antitumor	PROPN
ctmj-146	142	12	effect	effect	NOUN
ctmj-146	142	13	—	—	PUNCT
ctmj-146	142	14	which	which	PRON
ctmj-146	142	15	results	result	VERB
ctmj-146	142	16	in	in	ADP
ctmj-146	142	17	the	the	DET
ctmj-146	142	18	death	death	NOUN
ctmj-146	142	19	of	of	ADP
ctmj-146	142	20	cancer	cancer	NOUN
ctmj-146	142	21	cells	cell	NOUN
ctmj-146	142	22	and	and	CCONJ
ctmj-146	142	23	the	the	DET
ctmj-146	142	24	suppression	suppression	NOUN
ctmj-146	142	25	of	of	ADP
ctmj-146	142	26	metastasis	metastasis	NOUN
ctmj-146	142	27	—	—	PUNCT
ctmj-146	142	28	is	be	AUX
ctmj-146	142	29	evident	evident	ADJ
ctmj-146	142	30	.	.	PUNCT
ctmj-146	143	1	cvb	cvb	VERB
ctmj-146	143	2	-	-	PUNCT
ctmj-146	143	3	d	d	PROPN
ctmj-146	143	4	regulates	regulate	VERB
ctmj-146	143	5	cell	cell	NOUN
ctmj-146	143	6	cycle	cycle	NOUN
ctmj-146	143	7	progression	progression	NOUN
ctmj-146	143	8	,	,	PUNCT
ctmj-146	143	9	inhibits	inhibit	VERB
ctmj-146	143	10	metastasis	metastasis	NOUN
ctmj-146	143	11	,	,	PUNCT
ctmj-146	143	12	and	and	CCONJ
ctmj-146	143	13	activates	activate	VERB
ctmj-146	143	14	signaling	signal	VERB
ctmj-146	143	15	pathways	pathway	NOUN
ctmj-146	143	16	similar	similar	ADJ
ctmj-146	143	17	to	to	ADP
ctmj-146	143	18	those	those	PRON
ctmj-146	143	19	of	of	ADP
ctmj-146	143	20	other	other	ADJ
ctmj-146	143	21	steroidal	steroidal	NOUN
ctmj-146	143	22	alkaloids	alkaloid	NOUN
ctmj-146	143	23	.	.	PUNCT
ctmj-146	144	1	these	these	DET
ctmj-146	144	2	pathways	pathway	NOUN
ctmj-146	144	3	include	include	VERB
ctmj-146	144	4	up	up	ADV
ctmj-146	144	5	-	-	PUNCT
ctmj-146	144	6	or	or	CCONJ
ctmj-146	144	7	down	down	ADJ
ctmj-146	144	8	-	-	PUNCT
ctmj-146	144	9	regulation	regulation	NOUN
ctmj-146	144	10	of	of	ADP
ctmj-146	144	11	apoptotic	apoptotic	ADJ
ctmj-146	144	12	(	(	PUNCT
ctmj-146	144	13	bax	bax	PROPN
ctmj-146	144	14	,	,	PUNCT
ctmj-146	144	15	bcl	bcl	NOUN
ctmj-146	144	16	2	2	NUM
ctmj-146	144	17	,	,	PUNCT
ctmj-146	144	18	caspases	caspase	NOUN
ctmj-146	144	19	)	)	PUNCT
ctmj-146	144	20	and	and	CCONJ
ctmj-146	144	21	autophagic	autophagic	PROPN
ctmj-146	144	22	(	(	PUNCT
ctmj-146	144	23	lc3	lc3	PROPN
ctmj-146	144	24	,	,	PUNCT
ctmj-146	144	25	akt	akt	PROPN
ctmj-146	144	26	,	,	PUNCT
ctmj-146	144	27	mtor	mtor	PROPN
ctmj-146	144	28	)	)	PUNCT
ctmj-146	144	29	proteins.no	proteins.no	PROPN
ctmj-146	144	30	.	.	NOUN
ctmj-146	144	31	83	83	NUM
ctmj-146	145	1	unfortunately	unfortunately	ADV
ctmj-146	145	2	,	,	PUNCT
ctmj-146	145	3	the	the	DET
ctmj-146	145	4	chemical	chemical	NOUN
ctmj-146	145	5	effects	effect	NOUN
ctmj-146	145	6	that	that	PRON
ctmj-146	145	7	initiate	initiate	VERB
ctmj-146	145	8	these	these	DET
ctmj-146	145	9	reactions	reaction	NOUN
ctmj-146	145	10	remain	remain	VERB
ctmj-146	145	11	mostly	mostly	ADV
ctmj-146	145	12	unknown	unknown	ADJ
ctmj-146	145	13	.	.	PUNCT
ctmj-146	146	1	little	little	ADJ
ctmj-146	146	2	is	be	AUX
ctmj-146	146	3	known	know	VERB
ctmj-146	146	4	about	about	ADP
ctmj-146	146	5	the	the	DET
ctmj-146	146	6	significance	significance	NOUN
ctmj-146	146	7	or	or	CCONJ
ctmj-146	146	8	molecular	molecular	ADJ
ctmj-146	146	9	processes	process	NOUN
ctmj-146	146	10	that	that	PRON
ctmj-146	146	11	underlie	underlie	VERB
ctmj-146	146	12	the	the	DET
ctmj-146	146	13	anticancer	anticancer	NOUN
ctmj-146	146	14	action	action	NOUN
ctmj-146	146	15	.	.	PUNCT
ctmj-146	147	1	however	however	ADV
ctmj-146	147	2	,	,	PUNCT
ctmj-146	147	3	other	other	ADJ
ctmj-146	147	4	proteins	protein	NOUN
ctmj-146	147	5	might	might	AUX
ctmj-146	147	6	be	be	AUX
ctmj-146	147	7	suggested	suggest	VERB
ctmj-146	147	8	as	as	ADP
ctmj-146	147	9	possible	possible	ADJ
ctmj-146	147	10	targets	target	NOUN
ctmj-146	147	11	;	;	PUNCT
ctmj-146	147	12	for	for	ADP
ctmj-146	147	13	example	example	NOUN
ctmj-146	147	14	,	,	PUNCT
ctmj-146	147	15	egfr	egfr	NOUN
ctmj-146	147	16	and	and	CCONJ
ctmj-146	147	17	cthrc1	cthrc1	PROPN
ctmj-146	147	18	are	be	AUX
ctmj-146	147	19	known	know	VERB
ctmj-146	147	20	to	to	PART
ctmj-146	147	21	be	be	AUX
ctmj-146	147	22	involved	involve	VERB
ctmj-146	147	23	in	in	ADP
ctmj-146	147	24	cvb	cvb	PROPN
ctmj-146	147	25	-	-	PUNCT
ctmj-146	147	26	d	d	NOUN
ctmj-146	147	27	activity	activity	NOUN
ctmj-146	147	28	,	,	PUNCT
ctmj-146	147	29	and	and	CCONJ
ctmj-146	147	30	here	here	ADV
ctmj-146	147	31	we	we	PRON
ctmj-146	147	32	make	make	VERB
ctmj-146	147	33	a	a	DET
ctmj-146	147	34	more	more	ADV
ctmj-146	147	35	daring	daring	ADJ
ctmj-146	147	36	assumption	assumption	NOUN
ctmj-146	147	37	about	about	ADP
ctmj-146	147	38	s100a4	s100a4	PROPN
ctmj-146	147	39	.	.	PUNCT
ctmj-146	148	1	this	this	DET
ctmj-146	148	2	all	all	PRON
ctmj-146	148	3	-	-	PUNCT
ctmj-146	148	4	natural	natural	ADJ
ctmj-146	148	5	product	product	NOUN
ctmj-146	148	6	needs	need	VERB
ctmj-146	148	7	to	to	PART
ctmj-146	148	8	be	be	AUX
ctmj-146	148	9	promoted	promote	VERB
ctmj-146	148	10	and	and	CCONJ
ctmj-146	148	11	studied	study	VERB
ctmj-146	148	12	immediately	immediately	ADV
ctmj-146	148	13	.	.	PUNCT
ctmj-146	149	1	enhance	enhance	VERB
ctmj-146	149	2	its	its	PRON
ctmj-146	149	3	anticancer	anticancer	NOUN
ctmj-146	149	4	efficacy	efficacy	NOUN
ctmj-146	149	5	and	and	CCONJ
ctmj-146	149	6	mode	mode	NOUN
ctmj-146	149	7	of	of	ADP
ctmj-146	149	8	action	action	NOUN
ctmj-146	149	9	in	in	ADP
ctmj-146	149	10	living	live	VERB
ctmj-146	149	11	organisms	organism	NOUN
ctmj-146	149	12	.	.	PUNCT
ctmj-146	150	1	with	with	ADP
ctmj-146	150	2	any	any	DET
ctmj-146	150	3	luck	luck	NOUN
ctmj-146	150	4	,	,	PUNCT
ctmj-146	150	5	this	this	DET
ctmj-146	150	6	evaluation	evaluation	NOUN
ctmj-146	150	7	will	will	AUX
ctmj-146	150	8	serve	serve	VERB
ctmj-146	150	9	as	as	ADP
ctmj-146	150	10	a	a	DET
ctmj-146	150	11	catalyst	catalyst	NOUN
ctmj-146	150	12	for	for	ADP
ctmj-146	150	13	further	further	ADJ
ctmj-146	150	14	cvb	cvb	PROPN
ctmj-146	150	15	-	-	PUNCT
ctmj-146	150	16	d	d	PROPN
ctmj-146	150	17	testing	testing	NOUN
ctmj-146	150	18	in	in	ADP
ctmj-146	150	19	other	other	ADJ
ctmj-146	150	20	models	model	NOUN
ctmj-146	150	21	,	,	PUNCT
ctmj-146	150	22	perhaps	perhaps	ADV
ctmj-146	150	23	with	with	ADP
ctmj-146	150	24	more	more	ADV
ctmj-146	150	25	suitable	suitable	ADJ
ctmj-146	150	26	medication	medication	NOUN
ctmj-146	150	27	compositions	composition	NOUN
ctmj-146	150	28	and	and	CCONJ
ctmj-146	150	29	combinations	combination	NOUN
ctmj-146	150	30	.	.	PUNCT
ctmj-146	151	1	cvbd	cvbd	PROPN
ctmj-146	151	2	has	have	VERB
ctmj-146	151	3	a	a	DET
ctmj-146	151	4	lengthy	lengthy	ADJ
ctmj-146	151	5	history	history	NOUN
ctmj-146	151	6	of	of	ADP
ctmj-146	151	7	usage	usage	NOUN
ctmj-146	151	8	and	and	CCONJ
ctmj-146	151	9	a	a	DET
ctmj-146	151	10	high	high	ADJ
ctmj-146	151	11	safety	safety	NOUN
ctmj-146	151	12	profile	profile	NOUN
ctmj-146	151	13	;	;	PUNCT
ctmj-146	151	14	it	it	PRON
ctmj-146	151	15	may	may	AUX
ctmj-146	151	16	one	one	NUM
ctmj-146	151	17	day	day	NOUN
ctmj-146	151	18	be	be	AUX
ctmj-146	151	19	a	a	DET
ctmj-146	151	20	cancer	cancer	NOUN
ctmj-146	151	21	therapy	therapy	NOUN
ctmj-146	151	22	medicine	medicine	NOUN
ctmj-146	151	23	or	or	CCONJ
ctmj-146	151	24	a	a	DET
ctmj-146	151	25	molecular	molecular	ADJ
ctmj-146	151	26	tool	tool	NOUN
ctmj-146	151	27	to	to	PART
ctmj-146	151	28	alter	alter	VERB
ctmj-146	151	29	the	the	DET
ctmj-146	151	30	activity	activity	NOUN
ctmj-146	151	31	of	of	ADP
ctmj-146	151	32	the	the	DET
ctmj-146	151	33	proteins	protein	NOUN
ctmj-146	151	34	cthrc1	cthrc1	NOUN
ctmj-146	151	35	and	and	CCONJ
ctmj-146	151	36	s100a4	s100a4	PROPN
ctmj-146	151	37	,	,	PUNCT
ctmj-146	151	38	neither	neither	PRON
ctmj-146	151	39	of	of	ADP
ctmj-146	151	40	which	which	PRON
ctmj-146	151	41	have	have	VERB
ctmj-146	151	42	particular	particular	ADJ
ctmj-146	151	43	pharmacological	pharmacological	NOUN
ctmj-146	151	44	effectors	effector	NOUN
ctmj-146	151	45	at	at	ADP
ctmj-146	151	46	this	this	DET
ctmj-146	151	47	time	time	NOUN
ctmj-146	151	48	.	.	PUNCT
ctmj-146	152	1	funding	fund	VERB
ctmj-146	152	2	this	this	DET
ctmj-146	152	3	research	research	NOUN
ctmj-146	152	4	did	do	AUX
ctmj-146	152	5	not	not	PART
ctmj-146	152	6	receive	receive	VERB
ctmj-146	152	7	any	any	DET
ctmj-146	152	8	specific	specific	ADJ
ctmj-146	152	9	grant	grant	NOUN
ctmj-146	152	10	from	from	ADP
ctmj-146	152	11	funding	fund	VERB
ctmj-146	152	12	agencies	agency	NOUN
ctmj-146	152	13	in	in	ADP
ctmj-146	152	14	the	the	DET
ctmj-146	152	15	public	public	ADJ
ctmj-146	152	16	,	,	PUNCT
ctmj-146	152	17	commercial	commercial	ADJ
ctmj-146	152	18	,	,	PUNCT
ctmj-146	152	19	or	or	CCONJ
ctmj-146	152	20	not	not	PART
ctmj-146	152	21	-	-	PUNCT
ctmj-146	152	22	for	for	ADP
ctmj-146	152	23	-	-	PUNCT
ctmj-146	152	24	profit	profit	NOUN
ctmj-146	152	25	sectors	sector	NOUN
ctmj-146	152	26	.	.	PUNCT
ctmj-146	153	1	declaration	declaration	NOUN
ctmj-146	153	2	of	of	ADP
ctmj-146	153	3	competing	compete	VERB
ctmj-146	153	4	interest	interest	NOUN
ctmj-146	153	5	the	the	DET
ctmj-146	153	6	authors	author	NOUN
ctmj-146	153	7	declare	declare	VERB
ctmj-146	153	8	no	no	DET
ctmj-146	153	9	conflict	conflict	NOUN
ctmj-146	153	10	of	of	ADP
ctmj-146	153	11	interest	interest	NOUN
ctmj-146	153	12	associated	associate	VERB
ctmj-146	153	13	with	with	ADP
ctmj-146	153	14	this	this	DET
ctmj-146	153	15	publication	publication	NOUN
ctmj-146	153	16	and	and	CCONJ
ctmj-146	153	17	there	there	PRON
ctmj-146	153	18	has	have	AUX
ctmj-146	153	19	been	be	AUX
ctmj-146	153	20	no	no	DET
ctmj-146	153	21	significant	significant	ADJ
ctmj-146	153	22	financial	financial	ADJ
ctmj-146	153	23	support	support	NOUN
ctmj-146	153	24	for	for	ADP
ctmj-146	153	25	this	this	DET
ctmj-146	153	26	work	work	NOUN
ctmj-146	153	27	that	that	PRON
ctmj-146	153	28	could	could	AUX
ctmj-146	153	29	have	have	AUX
ctmj-146	153	30	influenced	influence	VERB
ctmj-146	153	31	its	its	PRON
ctmj-146	153	32	outcome	outcome	NOUN
ctmj-146	153	33	.	.	PUNCT
ctmj-146	154	1	credit	credit	NOUN
ctmj-146	154	2	authorship	authorship	NOUN
ctmj-146	154	3	contribution	contribution	NOUN
ctmj-146	154	4	statement	statement	NOUN
ctmj-146	154	5	christian	christian	PROPN
ctmj-146	154	6	bailly	bailly	ADV
ctmj-146	154	7	:	:	PUNCT
ctmj-146	154	8	conceptualization	conceptualization	NOUN
ctmj-146	154	9	,	,	PUNCT
ctmj-146	154	10	investigation	investigation	NOUN
ctmj-146	154	11	,	,	PUNCT
ctmj-146	154	12	project	project	NOUN
ctmj-146	154	13	administration	administration	NOUN
ctmj-146	154	14	,	,	PUNCT
ctmj-146	154	15	supervision	supervision	NOUN
ctmj-146	154	16	,	,	PUNCT
ctmj-146	154	17	writing	write	VERB
ctmj-146	154	18	‒	‒	ADP
ctmj-146	154	19	original	original	ADJ
ctmj-146	154	20	draft	draft	NOUN
ctmj-146	154	21	,	,	PUNCT
ctmj-146	154	22	and	and	CCONJ
ctmj-146	154	23	writing	write	VERB
ctmj-146	154	24	‒	‒	ADP
ctmj-146	154	25	review	review	NOUN
ctmj-146	154	26	&	&	CCONJ
ctmj-146	154	27	editing	editing	PROPN
ctmj-146	154	28	.	.	PUNCT
ctmj-146	155	1	jihong	jihong	PROPN
ctmj-146	155	2	zhang	zhang	PROPN
ctmj-146	155	3	:	:	PUNCT
ctmj-146	155	4	writing	write	VERB
ctmj-146	155	5	‒	‒	ADP
ctmj-146	155	6	review	review	NOUN
ctmj-146	155	7	&	&	CCONJ
ctmj-146	155	8	editing	editing	PROPN
ctmj-146	155	9	.	.	PUNCT
ctmj-146	156	1	references	reference	NOUN
ctmj-146	156	2	1.researchers	1.researchers	PROPN
ctmj-146	156	3	liang	liang	PROPN
ctmj-146	156	4	,	,	PUNCT
ctmj-146	156	5	wang	wang	PROPN
ctmj-146	156	6	,	,	PUNCT
ctmj-146	156	7	zhang	zhang	PROPN
ctmj-146	156	8	,	,	PUNCT
ctmj-146	156	9	yang	yang	PROPN
ctmj-146	156	10	,	,	PUNCT
ctmj-146	156	11	and	and	CCONJ
ctmj-146	156	12	li	li	PROPN
ctmj-146	156	13	investigated	investigate	VERB
ctmj-146	156	14	the	the	DET
ctmj-146	156	15	absorption	absorption	NOUN
ctmj-146	156	16	and	and	CCONJ
ctmj-146	156	17	arrest	arrest	NOUN
ctmj-146	156	18	of	of	ADP
ctmj-146	156	19	pm2.5	pm2.5	PROPN
ctmj-146	156	20	by	by	ADP
ctmj-146	156	21	common	common	ADJ
ctmj-146	156	22	beijing	beijing	PROPN
ctmj-146	156	23	shrubs	shrub	NOUN
ctmj-146	156	24	.	.	PUNCT
ctmj-146	157	1	kexue	kexue	NOUN
ctmj-146	157	2	huanjing	huanje	VERB
ctmj-146	157	3	.	.	PUNCT
ctmj-146	158	1	"	"	PUNCT
ctmj-146	158	2	chinese	chinese	ADJ
ctmj-146	158	3	"	"	PUNCT
ctmj-146	158	4	(	(	PUNCT
ctmj-146	158	5	2014:35(9	2014:35(9	NUM
ctmj-146	158	6	):	):	PUNCT
ctmj-146	158	7	3605–3611	3605–3611	NUM
ctmj-146	158	8	.	.	PUNCT
ctmj-146	159	1	2.shan	2.shan	NUM
ctmj-146	159	2	p	p	NOUN
ctmj-146	159	3	,	,	PUNCT
ctmj-146	159	4	mao	mao	NOUN
ctmj-146	159	5	rb	rb	PROPN
ctmj-146	159	6	,	,	PUNCT
ctmj-146	159	7	xu	xu	PROPN
ctmj-146	159	8	jm	jm	PROPN
ctmj-146	159	9	,	,	PUNCT
ctmj-146	159	10	and	and	CCONJ
ctmj-146	159	11	li	li	PROPN
ctmj-146	159	12	jx	jx	PROPN
ctmj-146	159	13	.	.	PROPN
ctmj-146	159	14	cyclovarirobuxine	cyclovarirobuxine	PROPN
ctmj-146	160	1	d	d	X
ctmj-146	160	2	's	's	PART
ctmj-146	160	3	(	(	PUNCT
ctmj-146	160	4	cvbd	cvbd	NOUN
ctmj-146	160	5	)	)	PUNCT
ctmj-146	160	6	therapeutic	therapeutic	ADJ
ctmj-146	160	7	benefits	benefit	NOUN
ctmj-146	160	8	in	in	ADP
ctmj-146	160	9	chd	chd	PROPN
ctmj-146	160	10	.	.	PUNCT
ctmj-146	161	1	an	an	DET
ctmj-146	161	2	investigation	investigation	NOUN
ctmj-146	161	3	of	of	ADP
ctmj-146	161	4	110	110	NUM
ctmj-146	161	5	instances	instance	NOUN
ctmj-146	161	6	using	use	VERB
ctmj-146	161	7	a	a	DET
ctmj-146	161	8	double	double	ADJ
ctmj-146	161	9	-	-	PUNCT
ctmj-146	161	10	blind	blind	ADJ
ctmj-146	161	11	model	model	NOUN
ctmj-146	161	12	.	.	PUNCT
ctmj-146	162	1	in	in	ADP
ctmj-146	162	2	:	:	PUNCT
ctmj-146	162	3	journal	journal	NOUN
ctmj-146	162	4	of	of	ADP
ctmj-146	162	5	traditional	traditional	ADJ
ctmj-146	162	6	chinese	chinese	ADJ
ctmj-146	162	7	medicine	medicine	NOUN
ctmj-146	162	8	,	,	PUNCT
ctmj-146	162	9	1984	1984	NUM
ctmj-146	162	10	,	,	PUNCT
ctmj-146	162	11	vol	vol	NOUN
ctmj-146	162	12	.	.	PROPN
ctmj-146	162	13	4	4	NUM
ctmj-146	162	14	,	,	PUNCT
ctmj-146	162	15	no	no	INTJ
ctmj-146	162	16	.	.	NOUN
ctmj-146	162	17	1	1	NUM
ctmj-146	162	18	,	,	PUNCT
ctmj-146	162	19	pages	page	NOUN
ctmj-146	162	20	15–19	15–19	NUM
ctmj-146	162	21	.	.	PUNCT
ctmj-146	163	1	3.three	3.three	NUM
ctmj-146	163	2	steroidal	steroidal	NOUN
ctmj-146	163	3	alkaloids	alkaloid	NOUN
ctmj-146	163	4	derived	derive	VERB
ctmj-146	163	5	from	from	ADP
ctmj-146	163	6	buxus	buxus	NOUN
ctmj-146	163	7	microphylla	microphylla	NOUN
ctmj-146	163	8	were	be	AUX
ctmj-146	163	9	studied	study	VERB
ctmj-146	163	10	by	by	ADP
ctmj-146	163	11	du	du	PROPN
ctmj-146	163	12	,	,	PUNCT
ctmj-146	163	13	chiu	chiu	PROPN
ctmj-146	163	14	,	,	PUNCT
ctmj-146	163	15	and	and	CCONJ
ctmj-146	163	16	nie	nie	PROPN
ctmj-146	163	17	.	.	PROPN
ctmj-146	164	1	article	article	NOUN
ctmj-146	164	2	published	publish	VERB
ctmj-146	164	3	in	in	ADP
ctmj-146	164	4	the	the	DET
ctmj-146	164	5	journal	journal	NOUN
ctmj-146	164	6	of	of	ADP
ctmj-146	164	7	asian	asian	ADJ
ctmj-146	164	8	natural	natural	ADJ
ctmj-146	164	9	product	product	NOUN
ctmj-146	164	10	research	research	NOUN
ctmj-146	164	11	in	in	ADP
ctmj-146	164	12	1999	1999	NUM
ctmj-146	164	13	,	,	PUNCT
ctmj-146	164	14	volume	volume	NOUN
ctmj-146	164	15	1	1	NUM
ctmj-146	164	16	,	,	PUNCT
ctmj-146	164	17	issue	issue	NOUN
ctmj-146	164	18	4	4	NUM
ctmj-146	164	19	,	,	PUNCT
ctmj-146	164	20	pages	page	NOUN
ctmj-146	164	21	239–244	239–244	NUM
ctmj-146	164	22	.	.	PUNCT
ctmj-146	165	1	4.authors	4.authors	NUM
ctmj-146	165	2	:	:	PUNCT
ctmj-146	165	3	yan	yan	PROPN
ctmj-146	165	4	yx	yx	PROPN
ctmj-146	165	5	,	,	PUNCT
ctmj-146	165	6	hu	hu	PROPN
ctmj-146	166	1	xd	xd	PROPN
ctmj-146	166	2	,	,	PUNCT
ctmj-146	166	3	chen	chen	PROPN
ctmj-146	166	4	jc	jc	PROPN
ctmj-146	166	5	,	,	PUNCT
ctmj-146	166	6	+	+	CCONJ
ctmj-146	166	7	more	more	ADJ
ctmj-146	166	8	.	.	PUNCT
ctmj-146	167	1	triterpenoid	triterpenoid	VERB
ctmj-146	167	2	alkaloids	alkaloid	NOUN
ctmj-146	167	3	derived	derive	VERB
ctmj-146	167	4	from	from	ADP
ctmj-146	167	5	buxus	buxus	NOUN
ctmj-146	167	6	microphylla	microphylla	NOUN
ctmj-146	167	7	that	that	PRON
ctmj-146	167	8	are	be	AUX
ctmj-146	167	9	cell	cell	NOUN
ctmj-146	167	10	-	-	PUNCT
ctmj-146	167	11	killing	killing	NOUN
ctmj-146	167	12	.	.	PUNCT
ctmj-146	168	1	biological	biological	ADJ
ctmj-146	168	2	products	product	NOUN
ctmj-146	168	3	journal	journal	NOUN
ctmj-146	168	4	.	.	PUNCT
ctmj-146	169	1	published	publish	VERB
ctmj-146	169	2	in	in	ADP
ctmj-146	169	3	2009	2009	NUM
ctmj-146	169	4	,	,	PUNCT
ctmj-146	169	5	volume	volume	NOUN
ctmj-146	169	6	72	72	NUM
ctmj-146	169	7	,	,	PUNCT
ctmj-146	169	8	issue	issue	NOUN
ctmj-146	169	9	2	2	NUM
ctmj-146	169	10	,	,	PUNCT
ctmj-146	169	11	pages	page	NOUN
ctmj-146	169	12	308–311	308–311	NUM
ctmj-146	169	13	.	.	PUNCT
ctmj-146	170	1	5.the	5.the	DET
ctmj-146	170	2	authors	author	NOUN
ctmj-146	170	3	of	of	ADP
ctmj-146	170	4	the	the	DET
ctmj-146	170	5	study	study	NOUN
ctmj-146	170	6	include	include	VERB
ctmj-146	170	7	yan	yan	PROPN
ctmj-146	170	8	yx	yx	PROPN
ctmj-146	170	9	,	,	PUNCT
ctmj-146	170	10	sun	sun	PROPN
ctmj-146	170	11	y	y	PROPN
ctmj-146	170	12	,	,	PUNCT
ctmj-146	170	13	chen	chen	PROPN
ctmj-146	170	14	jc	jc	PROPN
ctmj-146	170	15	,	,	PUNCT
ctmj-146	170	16	and	and	CCONJ
ctmj-146	170	17	others	other	NOUN
ctmj-146	170	18	.	.	PUNCT
ctmj-146	171	1	benzoate	benzoate	NOUN
ctmj-146	171	2	alkaloids	alkaloid	NOUN
ctmj-146	171	3	derived	derive	VERB
ctmj-146	171	4	from	from	ADP
ctmj-146	171	5	buxus	buxus	NOUN
ctmj-146	171	6	microphylla	microphylla	NOUN
ctmj-146	171	7	.	.	PUNCT
ctmj-146	172	1	organic	organic	ADJ
ctmj-146	172	2	biodiversity	biodiversity	NOUN
ctmj-146	172	3	.	.	PUNCT
ctmj-146	173	1	published	publish	VERB
ctmj-146	173	2	in	in	ADP
ctmj-146	173	3	2010;7(7):1822–1827	2010;7(7):1822–1827	NUM
ctmj-146	173	4	.	.	PUNCT
ctmj-146	174	1	6.authors	6.authors	NUM
ctmj-146	174	2	:	:	PUNCT
ctmj-146	174	3	bai	bai	PROPN
ctmj-146	174	4	st	st	PROPN
ctmj-146	174	5	,	,	PUNCT
ctmj-146	174	6	zhu	zhu	PROPN
ctmj-146	174	7	gl	gl	PROPN
ctmj-146	174	8	,	,	PUNCT
ctmj-146	174	9	peng	peng	PROPN
ctmj-146	174	10	xr	xr	PROPN
ctmj-146	174	11	,	,	PUNCT
ctmj-146	174	12	+	+	CCONJ
ctmj-146	174	13	more	more	ADJ
ctmj-146	174	14	.	.	PUNCT
ctmj-146	175	1	triterpenoid	triterpenoid	VERB
ctmj-146	175	2	alkaloids	alkaloid	NOUN
ctmj-146	175	3	derived	derive	VERB
ctmj-146	175	4	from	from	ADP
ctmj-146	175	5	buxus	buxus	NOUN
ctmj-146	175	6	microphylla	microphylla	NOUN
ctmj-146	175	7	and	and	CCONJ
ctmj-146	175	8	their	their	PRON
ctmj-146	175	9	cytotoxicity	cytotoxicity	NOUN
ctmj-146	175	10	to	to	ADP
ctmj-146	175	11	tumor	tumor	NOUN
ctmj-146	175	12	cell	cell	NOUN
ctmj-146	175	13	lines	line	NOUN
ctmj-146	175	14	derived	derive	VERB
ctmj-146	175	15	from	from	ADP
ctmj-146	175	16	humans	human	NOUN
ctmj-146	175	17	.	.	PUNCT
ctmj-146	176	1	small	small	ADJ
ctmj-146	176	2	biological	biological	ADJ
ctmj-146	176	3	units	unit	NOUN
ctmj-146	176	4	.	.	PUNCT
ctmj-146	177	1	the	the	DET
ctmj-146	177	2	year	year	NOUN
ctmj-146	177	3	2016;21(9):1125	2016;21(9):1125	NUM
ctmj-146	177	4	.	.	PUNCT
ctmj-146	178	1	7.kupchan	7.kupchan	NUM
ctmj-146	178	2	sm	sm	PROPN
ctmj-146	178	3	,	,	PUNCT
ctmj-146	178	4	brown	brown	PROPN
ctmj-146	178	5	jr	jr	PROPN
ctmj-146	178	6	ks	ks	PROPN
ctmj-146	178	7	.	.	PROPN
ctmj-146	178	8	buxus	buxus	PROPN
ctmj-146	178	9	alkaloids	alkaloids	PROPN
ctmj-146	178	10	.	.	PUNCT
ctmj-146	178	11	part	part	NOUN
ctmj-146	178	12	six	six	NUM
ctmj-146	178	13	.	.	PUNCT
ctmj-146	179	1	the	the	DET
ctmj-146	179	2	chemical	chemical	NOUN
ctmj-146	179	3	make	make	NOUN
ctmj-146	179	4	-	-	PUNCT
ctmj-146	179	5	up	up	NOUN
ctmj-146	179	6	of	of	ADP
ctmj-146	179	7	cyclovirouxined	cyclovirouxine	VERB
ctmj-146	179	8	,	,	PUNCT
ctmj-146	179	9	as	as	SCONJ
ctmj-146	179	10	reported	report	VERB
ctmj-146	179	11	in	in	ADP
ctmj-146	179	12	tetrahedron	tetrahedron	NOUN
ctmj-146	179	13	letters	letter	NOUN
ctmj-146	179	14	.	.	PUNCT
ctmj-146	180	1	the	the	DET
ctmj-146	180	2	reference	reference	NOUN
ctmj-146	180	3	for	for	ADP
ctmj-146	180	4	this	this	DET
ctmj-146	180	5	article	article	NOUN
ctmj-146	180	6	is	be	AUX
ctmj-146	180	7	1964;5(39):2895e2900	1964;5(39):2895e2900	NUM
ctmj-146	180	8	.	.	PUNCT
ctmj-146	181	1	8.wang	8.wang	NUM
ctmj-146	181	2	lz	lz	PROPN
ctmj-146	181	3	,	,	PUNCT
ctmj-146	181	4	shan	shan	PROPN
ctmj-146	181	5	wd	wd	PROPN
ctmj-146	181	6	.	.	PROPN
ctmj-146	181	7	cyclovirobuxine	cyclovirobuxine	PROPN
ctmj-146	181	8	d	d	PROPN
ctmj-146	181	9	,	,	PUNCT
ctmj-146	181	10	an	an	DET
ctmj-146	181	11	isolated	isolated	ADJ
ctmj-146	181	12	compound	compound	NOUN
ctmj-146	181	13	from	from	ADP
ctmj-146	181	14	buxus	buxus	PROPN
ctmj-146	181	15	microphylla	microphylla	PROPN
ctmj-146	181	16	sieb	sieb	PROPN
ctmj-146	181	17	.	.	PROPN
ctmj-146	181	18	identified	identify	VERB
ctmj-146	181	19	and	and	CCONJ
ctmj-146	181	20	isolated	isolate	VERB
ctmj-146	181	21	.	.	PUNCT
ctmj-146	182	1	oh	oh	INTJ
ctmj-146	182	2	no	no	INTJ
ctmj-146	182	3	.	.	PUNCT
ctmj-146	183	1	var	var	PROPN
ctmj-146	183	2	.	.	PUNCT
ctmj-146	184	1	decidua	decidua	PROPN
ctmj-146	184	2	rehd	rehd	PROPN
ctmj-146	184	3	.	.	PUNCT
ctmj-146	185	1	for	for	ADP
ctmj-146	185	2	xiaoyehuangyang	xiaoyehuangyang	PROPN
ctmj-146	185	3	et	et	PROPN
ctmj-146	185	4	wils	wils	PROPN
ctmj-146	185	5	.	.	PUNCT
ctmj-146	186	1	jiangsu	jiangsu	PROPN
ctmj-146	186	2	med	med	PROPN
ctmj-146	186	3	j.	j.	PROPN
ctmj-146	187	1	[	[	X
ctmj-146	187	2	chinese	chinese	PROPN
ctmj-146	187	3	]	]	X
ctmj-146	187	4	1979;10:14–16	1979;10:14–16	NUM
ctmj-146	187	5	.	.	PUNCT
ctmj-146	188	1	9.by	9.by	PROPN
ctmj-146	188	2	liang	liang	PROPN
ctmj-146	188	3	bw	bw	PROPN
ctmj-146	188	4	,	,	PUNCT
ctmj-146	188	5	deng	deng	PROPN
ctmj-146	188	6	ca	ca	PROPN
ctmj-146	188	7	,	,	PUNCT
ctmj-146	188	8	wang	wang	PROPN
ctmj-146	188	9	xb	xb	PROPN
ctmj-146	188	10	,	,	PUNCT
ctmj-146	188	11	and	and	CCONJ
ctmj-146	188	12	colleagues	colleague	NOUN
ctmj-146	188	13	.	.	PUNCT
ctmj-146	189	1	purification	purification	NOUN
ctmj-146	189	2	and	and	CCONJ
ctmj-146	189	3	molecular	molecular	ADJ
ctmj-146	189	4	identification	identification	NOUN
ctmj-146	189	5	of	of	ADP
ctmj-146	189	6	buxus	buxus	NOUN
ctmj-146	189	7	alkaloids	alkaloids	X
ctmj-146	189	8	i	i	PROPN
ctmj-146	189	9	,	,	PUNCT
ctmj-146	189	10	ii	ii	PROPN
ctmj-146	189	11	,	,	PUNCT
ctmj-146	189	12	iii	iii	PROPN
ctmj-146	189	13	,	,	PUNCT
ctmj-146	189	14	and	and	CCONJ
ctmj-146	189	15	iv	iv	X
ctmj-146	189	16	.	.	PUNCT
ctmj-146	190	1	chinese	chinese	ADJ
ctmj-146	190	2	journal	journal	PROPN
ctmj-146	190	3	of	of	ADP
ctmj-146	190	4	pharmacology	pharmacology	NOUN
ctmj-146	190	5	.	.	PUNCT
ctmj-146	191	1	[	[	X
ctmj-146	191	2	chinese	chinese	X
ctmj-146	191	3	]	]	X
ctmj-146	191	4	1981;16:195–199	1981;16:195–199	NUM
ctmj-146	191	5	.	.	PUNCT
ctmj-146	192	1	10.the	10.the	PRON
ctmj-146	192	2	cyclovir	cyclovir	NOUN
ctmj-146	192	3	.	.	PUNCT
ctmj-146	193	1	authors	author	NOUN
ctmj-146	193	2	:	:	PUNCT
ctmj-146	193	3	he	he	PRON
ctmj-146	193	4	xl	xl	PROPN
ctmj-146	193	5	,	,	PUNCT
ctmj-146	193	6	wang	wang	PROPN
ctmj-146	193	7	sb	sb	PROPN
ctmj-146	193	8	,	,	PUNCT
ctmj-146	193	9	and	and	CCONJ
ctmj-146	193	10	du	du	PROPN
ctmj-146	193	11	gh	gh	PROPN
ctmj-146	193	12	.	.	PROPN
ctmj-146	194	1	organic	organic	ADJ
ctmj-146	194	2	,	,	PUNCT
ctmj-146	194	3	low	low	ADJ
ctmj-146	194	4	-	-	PUNCT
ctmj-146	194	5	dosage	dosage	NOUN
ctmj-146	194	6	medications	medication	NOUN
ctmj-146	194	7	derived	derive	VERB
ctmj-146	194	8	from	from	ADP
ctmj-146	194	9	plants	plant	NOUN
ctmj-146	194	10	.	.	PUNCT
ctmj-146	195	1	publication	publication	NOUN
ctmj-146	195	2	date	date	NOUN
ctmj-146	195	3	:	:	PUNCT
ctmj-146	195	4	2018:25–29	2018:25–29	NUM
ctmj-146	195	5	by	by	ADP
ctmj-146	195	6	springer	springer	NOUN
ctmj-146	195	7	nature	nature	PROPN
ctmj-146	195	8	singapore	singapore	PROPN
ctmj-146	195	9	pte	pte	PROPN
ctmj-146	195	10	ltd	ltd	PROPN
ctmj-146	195	11	in	in	ADP
ctmj-146	195	12	singapore	singapore	PROPN
ctmj-146	195	13	.	.	PUNCT
ctmj-146	196	1	11.ke	11.ke	NUM
ctmj-146	196	2	zc	zc	X
ctmj-146	196	3	,	,	PUNCT
ctmj-146	196	4	hou	hou	PROPN
ctmj-146	196	5	xf	xf	PROPN
ctmj-146	196	6	,	,	PUNCT
ctmj-146	196	7	and	and	CCONJ
ctmj-146	196	8	jia	jia	PROPN
ctmj-146	196	9	xb	xb	PROPN
ctmj-146	196	10	.	.	PUNCT
ctmj-146	197	1	enhanced	enhance	VERB
ctmj-146	197	2	bioavailability	bioavailability	NOUN
ctmj-146	197	3	of	of	ADP
ctmj-146	197	4	cyclovirobuxine	cyclovirobuxine	NOUN
ctmj-146	197	5	d	d	PROPN
ctmj-146	197	6	by	by	ADP
ctmj-146	197	7	the	the	DET
ctmj-146	197	8	development	development	NOUN
ctmj-146	197	9	and	and	CCONJ
ctmj-146	197	10	optimization	optimization	NOUN
ctmj-146	197	11	of	of	ADP
ctmj-146	197	12	selfnanoemulsifying	selfnanoemulsifye	VERB
ctmj-146	197	13	drug	drug	NOUN
ctmj-146	197	14	delivery	delivery	NOUN
ctmj-146	197	15	systems	system	NOUN
ctmj-146	197	16	.	.	PUNCT
ctmj-146	198	1	medical	medical	ADJ
ctmj-146	198	2	drug	drug	NOUN
ctmj-146	198	3	research	research	NOUN
ctmj-146	198	4	and	and	CCONJ
ctmj-146	198	5	development	development	NOUN
ctmj-146	198	6	.	.	PUNCT
ctmj-146	199	1	publication	publication	NOUN
ctmj-146	199	2	date	date	NOUN
ctmj-146	199	3	:	:	PUNCT
ctmj-146	199	4	2016;10:2049e2060	2016;10:2049e2060	NUM
ctmj-146	199	5	.	.	PUNCT
ctmj-146	200	1	12.after	12.after	NUM
ctmj-146	200	2	8	8	NUM
ctmj-146	200	3	weeks	week	NOUN
ctmj-146	200	4	of	of	ADP
ctmj-146	200	5	repeated	repeat	VERB
ctmj-146	200	6	stomach	stomach	NOUN
ctmj-146	200	7	administration	administration	NOUN
ctmj-146	200	8	,	,	PUNCT
ctmj-146	200	9	the	the	DET
ctmj-146	200	10	toxicity	toxicity	NOUN
ctmj-146	200	11	of	of	ADP
ctmj-146	200	12	huangyangning	huangyangne	VERB
ctmj-146	200	13	dropping	drop	VERB
ctmj-146	200	14	tablets	tablet	NOUN
ctmj-146	200	15	on	on	ADP
ctmj-146	200	16	rats	rat	NOUN
ctmj-146	200	17	was	be	AUX
ctmj-146	200	18	studied	study	VERB
ctmj-146	200	19	by	by	ADP
ctmj-146	200	20	cheng	cheng	PROPN
ctmj-146	200	21	wh	wh	PROPN
ctmj-146	200	22	,	,	PUNCT
ctmj-146	200	23	fan	fan	PROPN
ctmj-146	200	24	bl	bl	PROPN
ctmj-146	200	25	,	,	PUNCT
ctmj-146	200	26	song	song	PROPN
ctmj-146	200	27	y	y	PROPN
ctmj-146	200	28	,	,	PUNCT
ctmj-146	200	29	and	and	CCONJ
ctmj-146	200	30	tian	tian	PROPN
ctmj-146	200	31	h.	h.	PROPN
ctmj-146	200	32	pharmaceutical	pharmaceutical	PROPN
ctmj-146	200	33	innovations	innovation	NOUN
ctmj-146	200	34	.	.	PUNCT
ctmj-146	201	1	e42	e42	PRON
ctmj-146	201	2	(	(	PUNCT
ctmj-146	201	3	2019;8(2	2019;8(2	NUM
ctmj-146	201	4	)	)	PUNCT
ctmj-146	201	5	)	)	PUNCT
ctmj-146	201	6	.	.	PUNCT
ctmj-146	202	1	13.citation	13.citation	NUM
ctmj-146	202	2	:	:	PUNCT
ctmj-146	202	3	yu	yu	PROPN
ctmj-146	202	4	b	b	PROPN
ctmj-146	202	5	,	,	PUNCT
ctmj-146	202	6	fang	fang	PROPN
ctmj-146	202	7	th	th	PROPN
ctmj-146	202	8	,	,	PUNCT
ctmj-146	202	9	lv	lv	PROPN
ctmj-146	202	10	gh	gh	PROPN
ctmj-146	202	11	,	,	PUNCT
ctmj-146	202	12	xu	xu	PROPN
ctmj-146	203	1	hq	hq	PROPN
ctmj-146	203	2	,	,	PUNCT
ctmj-146	203	3	lu	lu	PROPN
ctmj-146	203	4	jf	jf	PROPN
ctmj-146	203	5	.	.	PROPN
ctmj-146	203	6	cyclovirobuxine	cyclovirobuxine	PROPN
ctmj-146	204	1	d	d	PROPN
ctmj-146	204	2	's	's	PART
ctmj-146	204	3	beneficial	beneficial	ADJ
ctmj-146	204	4	impact	impact	NOUN
ctmj-146	204	5	on	on	ADP
ctmj-146	204	6	rats	rat	NOUN
ctmj-146	204	7	with	with	ADP
ctmj-146	204	8	heart	heart	NOUN
ctmj-146	204	9	failure	failure	NOUN
ctmj-146	204	10	after	after	ADP
ctmj-146	204	11	myocardial	myocardial	ADJ
ctmj-146	204	12	infarction	infarction	NOUN
ctmj-146	204	13	.	.	PUNCT
ctmj-146	205	1	exercise	exercise	NOUN
ctmj-146	205	2	therapy	therapy	NOUN
ctmj-146	205	3	.	.	PUNCT
ctmj-146	206	1	published	publish	VERB
ctmj-146	206	2	in	in	ADP
ctmj-146	206	3	2011	2011	NUM
ctmj-146	206	4	in	in	ADP
ctmj-146	206	5	volume	volume	NOUN
ctmj-146	206	6	82	82	NUM
ctmj-146	206	7	,	,	PUNCT
ctmj-146	206	8	issue	issue	NOUN
ctmj-146	206	9	6	6	NUM
ctmj-146	206	10	,	,	PUNCT
ctmj-146	206	11	pages	page	NOUN
ctmj-146	206	12	868–877	868–877	NUM
ctmj-146	206	13	.	.	PUNCT
ctmj-146	207	1	14.the	14.the	DET
ctmj-146	207	2	effect	effect	NOUN
ctmj-146	207	3	of	of	ADP
ctmj-146	207	4	cyclovirobuxine	cyclovirobuxine	NOUN
ctmj-146	207	5	d	d	PROPN
ctmj-146	207	6	on	on	ADP
ctmj-146	207	7	the	the	DET
ctmj-146	207	8	regulation	regulation	NOUN
ctmj-146	207	9	of	of	ADP
ctmj-146	207	10	intracellular	intracellular	NOUN
ctmj-146	207	11	[	[	X
ctmj-146	207	12	ca(2	ca(2	NOUN
ctmj-146	207	13	+	+	NOUN
ctmj-146	207	14	)	)	PUNCT
ctmj-146	207	15	]	]	PUNCT
ctmj-146	207	16	and	and	CCONJ
ctmj-146	207	17	the	the	DET
ctmj-146	207	18	expression	expression	NOUN
ctmj-146	207	19	of	of	ADP
ctmj-146	207	20	the	the	DET
ctmj-146	207	21	proteins	protein	NOUN
ctmj-146	207	22	involved	involve	VERB
ctmj-146	207	23	in	in	ADP
ctmj-146	207	24	calcium	calcium	NOUN
ctmj-146	207	25	cycling	cycling	NOUN
ctmj-146	207	26	in	in	ADP
ctmj-146	207	27	rat	rat	NOUN
ctmj-146	207	28	myocytes	myocyte	NOUN
ctmj-146	207	29	was	be	AUX
ctmj-146	207	30	studied	study	VERB
ctmj-146	207	31	by	by	ADP
ctmj-146	207	32	yu	yu	PROPN
ctmj-146	207	33	b	b	PROPN
ctmj-146	207	34	,	,	PUNCT
ctmj-146	207	35	ruan	ruan	PROPN
ctmj-146	207	36	m	m	PROPN
ctmj-146	207	37	,	,	PUNCT
ctmj-146	207	38	zhou	zhou	PROPN
ctmj-146	207	39	ll	ll	AUX
ctmj-146	207	40	,	,	PUNCT
ctmj-146	207	41	xu	xu	PROPN
ctmj-146	208	1	l	l	NOUN
ctmj-146	208	2	,	,	PUNCT
ctmj-146	208	3	and	and	CCONJ
ctmj-146	208	4	fang	fang	PROPN
ctmj-146	208	5	th	th	PROPN
ctmj-146	208	6	.	.	PUNCT
ctmj-146	208	7	exercise	exercise	NOUN
ctmj-146	208	8	therapy	therapy	NOUN
ctmj-146	208	9	.	.	PUNCT
ctmj-146	209	1	83(8	83(8	NUM
ctmj-146	209	2	):	):	PUNCT
ctmj-146	209	3	1653–1665	1653–1665	NUM
ctmj-146	209	4	(	(	PUNCT
ctmj-146	209	5	2012	2012	NUM
ctmj-146	209	6	)	)	PUNCT
ctmj-146	209	7	.	.	PUNCT
ctmj-146	210	1	15.in	15.in	NUM
ctmj-146	210	2	vivo	vivo	VERB
ctmj-146	210	3	experimental	experimental	ADJ
ctmj-146	210	4	myocardial	myocardial	ADJ
ctmj-146	210	5	injury	injury	NOUN
ctmj-146	210	6	in	in	ADP
ctmj-146	210	7	rats	rat	NOUN
ctmj-146	210	8	caused	cause	VERB
ctmj-146	210	9	by	by	ADP
ctmj-146	210	10	sympathetic	sympathetic	ADJ
ctmj-146	210	11	overactivity	overactivity	NOUN
ctmj-146	210	12	:	:	PUNCT
ctmj-146	210	13	ameliorated	ameliorate	VERB
ctmj-146	210	14	effects	effect	NOUN
ctmj-146	210	15	of	of	ADP
ctmj-146	210	16	cyclo	cyclo	NOUN
ctmj-146	210	17	-	-	PUNCT
ctmj-146	210	18	virobuxine	virobuxine	NOUN
ctmj-146	210	19	d	d	NOUN
ctmj-146	210	20	on	on	ADP
ctmj-146	210	21	oxidative	oxidative	ADJ
ctmj-146	210	22	stress	stress	NOUN
ctmj-146	210	23	and	and	CCONJ
ctmj-146	210	24	energy	energy	NOUN
ctmj-146	210	25	metabolism	metabolism	NOUN
ctmj-146	210	26	(	(	PUNCT
ctmj-146	210	27	xu	xu	PROPN
ctmj-146	210	28	yn	yn	PROPN
ctmj-146	210	29	,	,	PUNCT
ctmj-146	210	30	wang	wang	PROPN
ctmj-146	210	31	y	y	PROPN
ctmj-146	210	32	,	,	PUNCT
ctmj-146	210	33	bo	bo	PROPN
ctmj-146	210	34	s	s	PROPN
ctmj-146	210	35	,	,	PUNCT
ctmj-146	210	36	jiang	jiang	PROPN
ctmj-146	210	37	y	y	PROPN
ctmj-146	210	38	,	,	PUNCT
ctmj-146	210	39	liu	liu	PROPN
ctmj-146	210	40	xd	xd	PROPN
ctmj-146	210	41	,	,	PUNCT
ctmj-146	210	42	shen	shen	PROPN
ctmj-146	210	43	xc	xc	PROPN
ctmj-146	210	44	)	)	PUNCT
ctmj-146	210	45	.	.	PUNCT
ctmj-146	211	1	cai	cai	PROPN
ctmj-146	211	2	zhong	zhong	PROPN
ctmj-146	211	3	yao	yao	PROPN
ctmj-146	211	4	.	.	PUNCT
ctmj-146	212	1	chinese	chinese	ADJ
ctmj-146	212	2	version	version	NOUN
ctmj-146	212	3	:	:	PUNCT
ctmj-146	213	1	2014;37(7):1213–1217	2014;37(7):1213–1217	NUM
ctmj-146	213	2	.	.	PUNCT
ctmj-146	214	1	16.this	16.this	NUM
ctmj-146	214	2	work	work	NOUN
ctmj-146	214	3	was	be	AUX
ctmj-146	214	4	authored	author	VERB
ctmj-146	214	5	by	by	ADP
ctmj-146	214	6	zhou	zhou	PROPN
ctmj-146	214	7	l	l	PROPN
ctmj-146	214	8	,	,	PUNCT
ctmj-146	214	9	ao	ao	PROPN
ctmj-146	214	10	ly	ly	PROPN
ctmj-146	214	11	,	,	PUNCT
ctmj-146	214	12	yan	yan	PROPN
ctmj-146	214	13	yy	yy	PROPN
ctmj-146	214	14	,	,	PUNCT
ctmj-146	214	15	and	and	CCONJ
ctmj-146	214	16	others	other	NOUN
ctmj-146	214	17	.	.	PUNCT
ctmj-146	215	1	reducing	reduce	VERB
ctmj-146	215	2	neuronal	neuronal	ADJ
ctmj-146	215	3	apoptosis	apoptosis	NOUN
ctmj-146	215	4	by	by	ADP
ctmj-146	215	5	down	down	ADV
ctmj-146	215	6	-	-	PUNCT
ctmj-146	215	7	regulating	regulate	VERB
ctmj-146	215	8	the	the	DET
ctmj-146	215	9	jnk	jnk	PROPN
ctmj-146	215	10	signaling	signal	VERB
ctmj-146	215	11	pathway	pathway	NOUN
ctmj-146	215	12	is	be	AUX
ctmj-146	215	13	one	one	NUM
ctmj-146	215	14	method	method	NOUN
ctmj-146	215	15	jlx001	jlx001	PROPN
ctmj-146	215	16	ameliorates	ameliorate	NOUN
ctmj-146	215	17	ischemia	ischemia	NOUN
ctmj-146	215	18	/	/	SYM
ctmj-146	215	19	reperfusion	reperfusion	NOUN
ctmj-146	215	20	damage	damage	NOUN
ctmj-146	215	21	.	.	PUNCT
ctmj-146	216	1	brain	brain	NOUN
ctmj-146	216	2	research	research	NOUN
ctmj-146	216	3	.	.	PUNCT
ctmj-146	217	1	publication	publication	NOUN
ctmj-146	217	2	date	date	NOUN
ctmj-146	217	3	:	:	PUNCT
ctmj-146	217	4	2019;418:189–204	2019;418:189–204	NUM
ctmj-146	217	5	.	.	PUNCT
ctmj-146	218	1	17.members	17.members	NUM
ctmj-146	218	2	of	of	ADP
ctmj-146	218	3	the	the	DET
ctmj-146	218	4	research	research	NOUN
ctmj-146	218	5	team	team	NOUN
ctmj-146	218	6	:	:	PUNCT
ctmj-146	219	1	yan	yan	PROPN
ctmj-146	219	2	yy	yy	PROPN
ctmj-146	219	3	,	,	PUNCT
ctmj-146	219	4	ao	ao	PROPN
ctmj-146	219	5	ly	ly	PROPN
ctmj-146	219	6	,	,	PUNCT
ctmj-146	219	7	zhou	zhou	PROPN
ctmj-146	219	8	l	l	PROPN
ctmj-146	219	9	,	,	PUNCT
ctmj-146	219	10	jr	jr	PROPN
ctmj-146	219	11	.	.	PUNCT
ctmj-146	219	12	by	by	ADP
ctmj-146	219	13	preventing	prevent	VERB
ctmj-146	219	14	platelet	platelet	NOUN
ctmj-146	219	15	activation	activation	NOUN
ctmj-146	219	16	and	and	CCONJ
ctmj-146	219	17	thrombus	thrombus	NOUN
ctmj-146	219	18	formation	formation	NOUN
ctmj-146	219	19	,	,	PUNCT
ctmj-146	219	20	jlx001	jlx001	PROPN
ctmj-146	219	21	alleviates	alleviate	VERB
ctmj-146	219	22	cerebral	cerebral	ADJ
ctmj-146	219	23	ischemia	ischemia	NOUN
ctmj-146	219	24	in	in	ADP
ctmj-146	219	25	rats	rat	NOUN
ctmj-146	219	26	.	.	PUNCT
ctmj-146	220	1	medical	medical	ADJ
ctmj-146	220	2	pharmacist	pharmacist	NOUN
ctmj-146	220	3	.	.	PUNCT
ctmj-146	221	1	it	it	PRON
ctmj-146	221	2	was	be	AUX
ctmj-146	221	3	published	publish	VERB
ctmj-146	221	4	in	in	ADP
ctmj-146	221	5	2018	2018	NUM
ctmj-146	221	6	with	with	ADP
ctmj-146	221	7	the	the	DET
ctmj-146	221	8	doi	doi	NOUN
ctmj-146	221	9	:	:	PUNCT
ctmj-146	221	10	106:805e812	106:805e812	NUM
ctmj-146	221	11	.	.	PUNCT
ctmj-146	222	1	18.the	18.the	DET
ctmj-146	222	2	authors	author	NOUN
ctmj-146	222	3	of	of	ADP
ctmj-146	222	4	the	the	DET
ctmj-146	222	5	study	study	NOUN
ctmj-146	222	6	include	include	VERB
ctmj-146	222	7	qiu	qiu	PROPN
ctmj-146	222	8	yy	yy	PROPN
ctmj-146	222	9	,	,	PUNCT
ctmj-146	222	10	yin	yin	PROPN
ctmj-146	222	11	qy	qy	PROPN
ctmj-146	222	12	,	,	PUNCT
ctmj-146	222	13	fei	fei	PROPN
ctmj-146	222	14	yx	yx	PROPN
ctmj-146	222	15	,	,	PUNCT
ctmj-146	222	16	and	and	CCONJ
ctmj-146	222	17	others	other	NOUN
ctmj-146	222	18	.	.	PUNCT
ctmj-146	223	1	in	in	ADP
ctmj-146	223	2	pmcao	pmcao	NOUN
ctmj-146	223	3	rats	rat	NOUN
ctmj-146	223	4	,	,	PUNCT
ctmj-146	223	5	jlx001	jlx001	PROPN
ctmj-146	223	6	reduced	reduce	VERB
ctmj-146	223	7	oxidative	oxidative	ADJ
ctmj-146	223	8	stress	stress	NOUN
ctmj-146	223	9	and	and	CCONJ
ctmj-146	223	10	inflammation	inflammation	NOUN
ctmj-146	223	11	by	by	ADP
ctmj-146	223	12	blocking	block	VERB
ctmj-146	223	13	the	the	DET
ctmj-146	223	14	tlr2/4	tlr2/4	NOUN
ctmj-146	223	15	-	-	PUNCT
ctmj-146	223	16	nf	nf	INTJ
ctmj-146	223	17	-	-	PUNCT
ctmj-146	223	18	kb	kb	NOUN
ctmj-146	223	19	signaling	signal	VERB
ctmj-146	223	20	pathway	pathway	NOUN
ctmj-146	223	21	.	.	PUNCT
ctmj-146	224	1	in	in	ADP
ctmj-146	224	2	the	the	DET
ctmj-146	224	3	journal	journal	NOUN
ctmj-146	224	4	neurochemistry	neurochemistry	PROPN
ctmj-146	224	5	res	re	NOUN
ctmj-146	224	6	.	.	PROPN
ctmj-146	224	7	,	,	PUNCT
ctmj-146	224	8	the	the	DET
ctmj-146	224	9	article	article	NOUN
ctmj-146	224	10	was	be	AUX
ctmj-146	224	11	published	publish	VERB
ctmj-146	224	12	in	in	ADP
ctmj-146	224	13	2019	2019	NUM
ctmj-146	224	14	with	with	ADP
ctmj-146	224	15	the	the	DET
ctmj-146	224	16	doi	doi	NOUN
ctmj-146	224	17	:	:	PUNCT
ctmj-146	224	18	44(8	44(8	NUM
ctmj-146	224	19	):	):	PUNCT
ctmj-146	224	20	1924–1938	1924–1938	NUM
ctmj-146	224	21	.	.	PUNCT
ctmj-146	225	1	19.the	19.the	DET
ctmj-146	225	2	authors	author	NOUN
ctmj-146	225	3	of	of	ADP
ctmj-146	225	4	the	the	DET
ctmj-146	225	5	study	study	NOUN
ctmj-146	225	6	are	be	AUX
ctmj-146	225	7	ao	ao	NOUN
ctmj-146	225	8	ly	ly	PROPN
ctmj-146	225	9	,	,	PUNCT
ctmj-146	225	10	li	li	PROPN
ctmj-146	225	11	wt	wt	PROPN
ctmj-146	225	12	,	,	PUNCT
ctmj-146	225	13	and	and	CCONJ
ctmj-146	225	14	zhou	zhou	PROPN
ctmj-146	225	15	l.	l.	PROPN
ctmj-146	225	16	treatment	treatment	NOUN
ctmj-146	225	17	of	of	ADP
ctmj-146	225	18	ischemic	ischemic	ADJ
ctmj-146	225	19	stroke	stroke	NOUN
ctmj-146	225	20	in	in	ADP
ctmj-146	225	21	rats	rat	NOUN
ctmj-146	225	22	with	with	ADP
ctmj-146	225	23	jlx-001	jlx-001	VERB
ctmj-146	225	24	by	by	ADP
ctmj-146	225	25	activation	activation	NOUN
ctmj-146	225	26	of	of	ADP
ctmj-146	225	27	the	the	DET
ctmj-146	225	28	autophagy	autophagy	ADJ
ctmj-146	225	29	mechanism	mechanism	NOUN
ctmj-146	225	30	through	through	ADP
ctmj-146	225	31	the	the	DET
ctmj-146	225	32	ampk	ampk	NOUN
ctmj-146	225	33	-	-	PUNCT
ctmj-146	225	34	ulk1	ulk1	PROPN
ctmj-146	225	35	signaling	signal	VERB
ctmj-146	225	36	pathway	pathway	NOUN
ctmj-146	225	37	.	.	PUNCT
ctmj-146	226	1	research	research	NOUN
ctmj-146	226	2	in	in	ADP
ctmj-146	226	3	brain	brain	NOUN
ctmj-146	226	4	diseases	disease	NOUN
ctmj-146	226	5	journal	journal	NOUN
ctmj-146	226	6	.	.	PUNCT
ctmj-146	227	1	the	the	DET
ctmj-146	227	2	current	current	ADJ
ctmj-146	227	3	version	version	NOUN
ctmj-146	227	4	is	be	AUX
ctmj-146	227	5	2019	2019	NUM
ctmj-146	227	6	at	at	ADP
ctmj-146	227	7	153:162e170	153:162e170	NUM
ctmj-146	227	8	.	.	PUNCT
ctmj-146	228	1	20.cyclovirobuxine	20.cyclovirobuxine	PUNCT
ctmj-146	229	1	d	d	NOUN
ctmj-146	229	2	leads	lead	VERB
ctmj-146	229	3	to	to	ADP
ctmj-146	229	4	autophagyassociated	autophagyassociate	VERB
ctmj-146	229	5	cell	cell	NOUN
ctmj-146	229	6	death	death	NOUN
ctmj-146	229	7	in	in	ADP
ctmj-146	229	8	mcf-7	mcf-7	VERB
ctmj-146	229	9	human	human	ADJ
ctmj-146	229	10	breast	breast	NOUN
ctmj-146	229	11	cancer	cancer	NOUN
ctmj-146	229	12	cells	cell	NOUN
ctmj-146	229	13	via	via	ADP
ctmj-146	229	14	the	the	DET
ctmj-146	229	15	akt	akt	PROPN
ctmj-146	229	16	/	/	SYM
ctmj-146	229	17	mtor	mtor	PROPN
ctmj-146	229	18	pathway	pathway	NOUN
ctmj-146	229	19	,	,	PUNCT
ctmj-146	229	20	according	accord	VERB
ctmj-146	229	21	to	to	ADP
ctmj-146	229	22	a	a	DET
ctmj-146	229	23	study	study	NOUN
ctmj-146	229	24	by	by	ADP
ctmj-146	229	25	lu	lu	PROPN
ctmj-146	229	26	j	j	PROPN
ctmj-146	229	27	,	,	PUNCT
ctmj-146	229	28	sun	sun	NOUN
ctmj-146	229	29	dp	dp	PROPN
ctmj-146	229	30	,	,	PUNCT
ctmj-146	229	31	gao	gao	PROPN
ctmj-146	229	32	s	s	PROPN
ctmj-146	229	33	,	,	PUNCT
ctmj-146	229	34	gao	gao	PROPN
ctmj-146	229	35	y	y	PROPN
ctmj-146	229	36	,	,	PUNCT
ctmj-146	229	37	ye	ye	PROPN
ctmj-146	229	38	jt	jt	PROPN
ctmj-146	229	39	,	,	PUNCT
ctmj-146	229	40	and	and	CCONJ
ctmj-146	229	41	liu	liu	PROPN
ctmj-146	229	42	pq	pq	PROPN
ctmj-146	229	43	.	.	PUNCT
ctmj-146	229	44	current	current	ADJ
ctmj-146	229	45	pharmaceutical	pharmaceutical	ADJ
ctmj-146	229	46	science	science	NOUN
ctmj-146	229	47	.	.	PUNCT
ctmj-146	230	1	published	publish	VERB
ctmj-146	230	2	in	in	ADP
ctmj-146	230	3	2014	2014	NUM
ctmj-146	230	4	,	,	PUNCT
ctmj-146	230	5	volume	volume	NOUN
ctmj-146	230	6	125	125	NUM
ctmj-146	230	7	,	,	PUNCT
ctmj-146	230	8	issue	issue	NOUN
ctmj-146	230	9	1	1	NUM
ctmj-146	230	10	,	,	PUNCT
ctmj-146	230	11	pages	page	NOUN
ctmj-146	230	12	74	74	NUM
ctmj-146	230	13	–	–	SYM
ctmj-146	230	14	82	82	NUM
ctmj-146	230	15	.	.	PUNCT
ctmj-146	231	1	21.the	21.the	PROPN
ctmj-146	231	2	study	study	NOUN
ctmj-146	231	3	conducted	conduct	VERB
ctmj-146	231	4	by	by	ADP
ctmj-146	231	5	wu	wu	PROPN
ctmj-146	231	6	et	et	PROPN
ctmj-146	231	7	al	al	PROPN
ctmj-146	231	8	.	.	PROPN
ctmj-146	231	9	found	find	VERB
ctmj-146	231	10	that	that	DET
ctmj-146	231	11	cyclovirobuxine	cyclovirobuxine	NOUN
ctmj-146	231	12	d	d	PROPN
ctmj-146	231	13	causes	cause	VERB
ctmj-146	231	14	mitochondria	mitochondria	NOUN
ctmj-146	231	15	-	-	PUNCT
ctmj-146	231	16	mediated	mediate	VERB
ctmj-146	231	17	apoptosis	apoptosis	NOUN
ctmj-146	231	18	in	in	ADP
ctmj-146	231	19	human	human	ADJ
ctmj-146	231	20	gastric	gastric	ADJ
ctmj-146	231	21	cancer	cancer	NOUN
ctmj-146	231	22	cells	cell	NOUN
ctmj-146	231	23	while	while	SCONJ
ctmj-146	231	24	simultaneously	simultaneously	ADV
ctmj-146	231	25	inhibiting	inhibit	VERB
ctmj-146	231	26	cell	cell	NOUN
ctmj-146	231	27	growth	growth	NOUN
ctmj-146	231	28	.	.	PUNCT
ctmj-146	232	1	small	small	ADJ
ctmj-146	232	2	,	,	PUNCT
ctmj-146	232	3	unitary	unitary	ADJ
ctmj-146	232	4	compounds	compound	NOUN
ctmj-146	232	5	.	.	PUNCT
ctmj-146	233	1	this	this	DET
ctmj-146	233	2	page	page	NOUN
ctmj-146	233	3	was	be	AUX
ctmj-146	233	4	last	last	ADV
ctmj-146	233	5	modified	modify	VERB
ctmj-146	233	6	on	on	ADP
ctmj-146	233	7	november	november	PROPN
ctmj-146	233	8	20	20	NUM
ctmj-146	233	9	,	,	PUNCT
ctmj-146	233	10	2015	2015	NUM
ctmj-146	233	11	,	,	PUNCT
ctmj-146	233	12	at	at	ADP
ctmj-146	233	13	20659	20659	NUM
ctmj-146	233	14	et	et	NOUN
ctmj-146	233	15	20668	20668	NUM
ctmj-146	233	16	.	.	PUNCT
ctmj-146	234	1	22.cyclovirobuxinum	22.cyclovirobuxinum	NUM
ctmj-146	234	2	d	d	NOUN
ctmj-146	234	3	inhibits	inhibit	VERB
ctmj-146	234	4	the	the	DET
ctmj-146	234	5	jak	jak	PROPN
ctmj-146	234	6	-	-	PUNCT
ctmj-146	234	7	stat	stat	PROPN
ctmj-146	234	8	signaling	signal	VERB
ctmj-146	234	9	pathway	pathway	NOUN
ctmj-146	234	10	,	,	PUNCT
ctmj-146	234	11	which	which	PRON
ctmj-146	234	12	in	in	ADP
ctmj-146	234	13	turn	turn	NOUN
ctmj-146	234	14	reduces	reduce	VERB
ctmj-146	234	15	lipopolysaccharide	lipopolysaccharide	ADV
ctmj-146	234	16	-	-	PUNCT
ctmj-146	234	17	induced	induce	VERB
ctmj-146	234	18	inflammatory	inflammatory	ADJ
ctmj-146	234	19	responses	response	NOUN
ctmj-146	234	20	in	in	ADP
ctmj-146	234	21	murine	murine	ADJ
ctmj-146	234	22	macrophages	macrophage	NOUN
ctmj-146	234	23	in	in	ADP
ctmj-146	234	24	vitro	vitro	X
ctmj-146	234	25	(	(	PUNCT
ctmj-146	234	26	guo	guo	PROPN
ctmj-146	234	27	d	d	PROPN
ctmj-146	234	28	,	,	PUNCT
ctmj-146	234	29	li	li	PROPN
ctmj-146	234	30	jr	jr	PROPN
ctmj-146	234	31	,	,	PUNCT
ctmj-146	234	32	wang	wang	PROPN
ctmj-146	234	33	y	y	PROPN
ctmj-146	234	34	,	,	PUNCT
ctmj-146	234	35	lei	lei	PROPN
ctmj-146	234	36	ls	ls	PROPN
ctmj-146	234	37	,	,	PUNCT
ctmj-146	234	38	yu	yu	PROPN
ctmj-146	234	39	cl	cl	PROPN
ctmj-146	234	40	,	,	PUNCT
ctmj-146	234	41	chen	chen	PROPN
ctmj-146	234	42	nn	nn	PROPN
ctmj-146	234	43	)	)	PUNCT
ctmj-146	234	44	.	.	PUNCT
ctmj-146	235	1	published	publish	VERB
ctmj-146	235	2	in	in	ADP
ctmj-146	235	3	the	the	DET
ctmj-146	235	4	journal	journal	NOUN
ctmj-146	235	5	acta	acta	PROPN
ctmj-146	235	6	pharmacol	pharmacol	PROPN
ctmj-146	235	7	sin	sin	NOUN
ctmj-146	235	8	.	.	PUNCT
ctmj-146	236	1	published	publish	VERB
ctmj-146	236	2	in	in	ADP
ctmj-146	236	3	2014	2014	NUM
ctmj-146	236	4	,	,	PUNCT
ctmj-146	236	5	volume	volume	NOUN
ctmj-146	236	6	35	35	NUM
ctmj-146	236	7	,	,	PUNCT
ctmj-146	236	8	issue	issue	NOUN
ctmj-146	236	9	6	6	NUM
ctmj-146	236	10	,	,	PUNCT
ctmj-146	236	11	pages	page	NOUN
ctmj-146	236	12	770	770	NUM
ctmj-146	236	13	–	–	PUNCT
ctmj-146	236	14	778	778	NUM
ctmj-146	236	15	.	.	PUNCT
ctmj-146	237	1	23.our	23.our	PRON
ctmj-146	237	2	group	group	NOUN
ctmj-146	237	3	includes	include	VERB
ctmj-146	237	4	lq	lq	PROPN
ctmj-146	237	5	zhou	zhou	PROPN
ctmj-146	237	6	,	,	PUNCT
ctmj-146	237	7	h	h	PROPN
ctmj-146	237	8	tang	tang	PROPN
ctmj-146	237	9	,	,	PUNCT
ctmj-146	237	10	f	f	PROPN
ctmj-146	237	11	wang	wang	PROPN
ctmj-146	237	12	,	,	PUNCT
ctmj-146	237	13	and	and	CCONJ
ctmj-146	237	14	others	other	NOUN
ctmj-146	237	15	.	.	PUNCT
ctmj-146	238	1	cyclovirobuxine	cyclovirobuxine	PROPN
ctmj-146	238	2	d	d	PROPN
ctmj-146	238	3	promotes	promote	VERB
ctmj-146	238	4	cell	cell	NOUN
ctmj-146	238	5	death	death	NOUN
ctmj-146	238	6	and	and	CCONJ
ctmj-146	238	7	inhibits	inhibit	VERB
ctmj-146	238	8	migration	migration	NOUN
ctmj-146	238	9	and	and	CCONJ
ctmj-146	238	10	proliferation	proliferation	NOUN
ctmj-146	238	11	in	in	ADP
ctmj-146	238	12	lowgrade	lowgrade	NOUN
ctmj-146	238	13	gliomas	glioma	NOUN
ctmj-146	238	14	and	and	CCONJ
ctmj-146	238	15	glioblastoma	glioblastoma	NOUN
ctmj-146	238	16	multiformes	multiforme	NOUN
ctmj-146	238	17	in	in	ADP
ctmj-146	238	18	humans	human	NOUN
ctmj-146	238	19	.	.	PUNCT
ctmj-146	239	1	the	the	DET
ctmj-146	239	2	article	article	NOUN
ctmj-146	239	3	is	be	AUX
ctmj-146	239	4	published	publish	VERB
ctmj-146	239	5	in	in	ADP
ctmj-146	239	6	the	the	DET
ctmj-146	239	7	oncology	oncology	NOUN
ctmj-146	239	8	reports	report	NOUN
ctmj-146	239	9	journal	journal	PROPN
ctmj-146	239	10	and	and	CCONJ
ctmj-146	239	11	has	have	VERB
ctmj-146	239	12	the	the	DET
ctmj-146	239	13	doi	doi	NOUN
ctmj-146	239	14	:	:	PUNCT
ctmj-146	239	15	43	43	NUM
ctmj-146	239	16	(	(	PUNCT
ctmj-146	239	17	6	6	NUM
ctmj-146	239	18	):	):	PUNCT
ctmj-146	239	19	807–819	807–819	NUM
ctmj-146	239	20	.	.	PUNCT
ctmj-146	240	1	24.authors	24.authors	NUM
ctmj-146	240	2	:	:	PUNCT
ctmj-146	240	3	zhang	zhang	PROPN
ctmj-146	240	4	jw	jw	PROPN
ctmj-146	240	5	,	,	PUNCT
ctmj-146	240	6	chen	chen	PROPN
ctmj-146	240	7	yd	yd	PROPN
ctmj-146	240	8	,	,	PUNCT
ctmj-146	240	9	lin	lin	PROPN
ctmj-146	240	10	j	j	PROPN
ctmj-146	240	11	,	,	PUNCT
ctmj-146	240	12	...	...	PUNCT
ctmj-146	240	13	cyclovirobuxine	cyclovirobuxine	PROPN
ctmj-146	241	1	d	d	PROPN
ctmj-146	241	2	inhibits	inhibit	VERB
ctmj-146	241	3	the	the	DET
ctmj-146	241	4	egfr	egfr	ADJ
ctmj-146	241	5	-	-	PUNCT
ctmj-146	241	6	fakakt	fakakt	NOUN
ctmj-146	241	7	/	/	SYM
ctmj-146	241	8	erk1/2	erk1/2	NOUN
ctmj-146	241	9	-	-	PUNCT
ctmj-146	241	10	slug	slug	NOUN
ctmj-146	241	11	signaling	signal	VERB
ctmj-146	241	12	cascade	cascade	NOUN
ctmj-146	241	13	in	in	ADP
ctmj-146	241	14	human	human	ADJ
ctmj-146	241	15	hepatocellular	hepatocellular	ADJ
ctmj-146	241	16	carcinoma	carcinoma	NOUN
ctmj-146	241	17	,	,	PUNCT
ctmj-146	241	18	which	which	PRON
ctmj-146	241	19	leads	lead	VERB
ctmj-146	241	20	to	to	ADP
ctmj-146	241	21	anticancer	anticancer	NOUN
ctmj-146	241	22	effects	effect	NOUN
ctmj-146	241	23	.	.	PUNCT
ctmj-146	242	1	genetics	genetic	NOUN
ctmj-146	242	2	and	and	CCONJ
ctmj-146	242	3	cellular	cellular	ADJ
ctmj-146	242	4	biology	biology	NOUN
ctmj-146	242	5	article	article	NOUN
ctmj-146	242	6	.	.	PUNCT
ctmj-146	243	1	in	in	ADP
ctmj-146	243	2	2020	2020	NUM
ctmj-146	243	3	,	,	PUNCT
ctmj-146	243	4	volume	volume	NOUN
ctmj-146	243	5	39	39	NUM
ctmj-146	243	6	,	,	PUNCT
ctmj-146	243	7	issue	issue	NOUN
ctmj-146	243	8	3	3	NUM
ctmj-146	243	9	,	,	PUNCT
ctmj-146	243	10	pages	page	NOUN
ctmj-146	243	11	355	355	NUM
ctmj-146	243	12	-	-	SYM
ctmj-146	243	13	236	236	NUM
ctmj-146	243	14	.	.	PUNCT
ctmj-146	244	1	25.authors	25.authors	NUM
ctmj-146	244	2	:	:	PUNCT
ctmj-146	244	3	jiang	jiang	PROPN
ctmj-146	244	4	fq	fq	PROPN
ctmj-146	244	5	,	,	PUNCT
ctmj-146	244	6	chen	chen	PROPN
ctmj-146	244	7	yd	yd	PROPN
ctmj-146	244	8	,	,	PUNCT
ctmj-146	244	9	ren	ren	PROPN
ctmj-146	244	10	s	s	PROPN
ctmj-146	244	11	,	,	PUNCT
ctmj-146	244	12	...	...	PUNCT
ctmj-146	244	13	through	through	ADP
ctmj-146	244	14	the	the	DET
ctmj-146	244	15	cthrc1	cthrc1	PROPN
ctmj-146	244	16	-	-	PUNCT
ctmj-146	244	17	akt	akt	PROPN
ctmj-146	244	18	/	/	SYM
ctmj-146	244	19	erk	erk	PROPN
ctmj-146	244	20	-	-	PUNCT
ctmj-146	244	21	snail	snail	NOUN
ctmj-146	244	22	signaling	signal	VERB
ctmj-146	244	23	pathway	pathway	NOUN
ctmj-146	244	24	,	,	PUNCT
ctmj-146	244	25	cyclovirobuxine	cyclovirobuxine	PROPN
ctmj-146	245	1	d	d	PROPN
ctmj-146	245	2	suppresses	suppress	VERB
ctmj-146	245	3	the	the	DET
ctmj-146	245	4	carcinogenesis	carcinogenesis	NOUN
ctmj-146	245	5	of	of	ADP
ctmj-146	245	6	colorectal	colorectal	ADJ
ctmj-146	245	7	cancer	cancer	NOUN
ctmj-146	245	8	.	.	PUNCT
ctmj-146	246	1	the	the	DET
ctmj-146	246	2	international	international	ADJ
ctmj-146	246	3	journal	journal	NOUN
ctmj-146	246	4	of	of	ADP
ctmj-146	246	5	cancer	cancer	NOUN
ctmj-146	246	6	.	.	PUNCT
ctmj-146	247	1	57(1	57(1	NUM
ctmj-146	247	2	):	):	PUNCT
ctmj-146	247	3	183–196	183–196	NUM
ctmj-146	247	4	,	,	PUNCT
ctmj-146	247	5	2020	2020	NUM
ctmj-146	247	6	.	.	PUNCT
ctmj-146	248	1	26.inflammatory	26.inflammatory	NUM
ctmj-146	248	2	and	and	CCONJ
ctmj-146	248	3	tumor	tumor	NOUN
ctmj-146	248	4	illnesses	illness	NOUN
ctmj-146	248	5	involving	involve	VERB
ctmj-146	248	6	collagen	collagen	NOUN
ctmj-146	248	7	triple	triple	ADJ
ctmj-146	248	8	helix	helix	ADJ
ctmj-146	248	9	repeat	repeat	NOUN
ctmj-146	248	10	containing-1	containing-1	NUM
ctmj-146	248	11	:	:	PUNCT
ctmj-146	248	12	a	a	DET
ctmj-146	248	13	role	role	NOUN
ctmj-146	248	14	for	for	ADP
ctmj-146	248	15	wu	wu	PROPN
ctmj-146	248	16	q	q	PROPN
ctmj-146	248	17	,	,	PUNCT
ctmj-146	248	18	yang	yang	PROPN
ctmj-146	248	19	qr	qr	PROPN
ctmj-146	248	20	,	,	PUNCT
ctmj-146	248	21	and	and	CCONJ
ctmj-146	248	22	sun	sun	PROPN
ctmj-146	248	23	hs	hs	PROPN
ctmj-146	248	24	.	.	PROPN
ctmj-146	248	25	clinical	clinical	ADJ
ctmj-146	248	26	cancer	cancer	NOUN
ctmj-146	248	27	research	research	NOUN
ctmj-146	248	28	.	.	PUNCT
ctmj-146	249	1	the	the	DET
ctmj-146	249	2	last	last	ADJ
ctmj-146	249	3	citation	citation	NOUN
ctmj-146	249	4	was	be	AUX
ctmj-146	249	5	2017;13(4):621	2017;13(4):621	NUM
ctmj-146	249	6	–	–	PUNCT
ctmj-146	249	7	624	624	NUM
ctmj-146	249	8	.	.	PUNCT
ctmj-146	250	1	27.cyclovirobuxine	27.cyclovirobuxine	NUM
ctmj-146	250	2	d	d	NOUN
ctmj-146	250	3	improves	improve	VERB
ctmj-146	250	4	acute	acute	ADJ
ctmj-146	250	5	myocardial	myocardial	ADJ
ctmj-146	250	6	ischemia	ischemia	NOUN
ctmj-146	250	7	by	by	ADP
ctmj-146	250	8	opening	opening	NOUN
ctmj-146	250	9	of	of	ADP
ctmj-146	250	10	the	the	DET
ctmj-146	250	11	k(atp	k(atp	ADJ
ctmj-146	250	12	)	)	PUNCT
ctmj-146	250	13	channel	channel	NOUN
ctmj-146	250	14	,	,	PUNCT
ctmj-146	250	15	generation	generation	NOUN
ctmj-146	250	16	of	of	ADP
ctmj-146	250	17	nitric	nitric	ADJ
ctmj-146	250	18	oxide	oxide	NOUN
ctmj-146	250	19	,	,	PUNCT
ctmj-146	250	20	and	and	CCONJ
ctmj-146	250	21	anti	anti	ADJ
ctmj-146	250	22	-	-	NOUN
ctmj-146	250	23	thrombosis	thrombosis	NOUN
ctmj-146	250	24	(	(	PUNCT
ctmj-146	250	25	hu	hu	PROPN
ctmj-146	251	1	d	d	PROPN
ctmj-146	251	2	,	,	PUNCT
ctmj-146	251	3	liu	liu	PROPN
ctmj-146	251	4	xy	xy	PROPN
ctmj-146	251	5	,	,	PUNCT
ctmj-146	251	6	wang	wang	PROPN
ctmj-146	251	7	yy	yy	PROPN
ctmj-146	251	8	,	,	PUNCT
ctmj-146	251	9	chen	chen	PROPN
ctmj-146	251	10	sz	sz	PROPN
ctmj-146	251	11	.	.	PUNCT
ctmj-146	251	12	)	)	PUNCT
ctmj-146	251	13	.	.	PUNCT
ctmj-146	252	1	clinical	clinical	ADJ
ctmj-146	252	2	pharmacology	pharmacology	NOUN
ctmj-146	252	3	.	.	PUNCT
ctmj-146	253	1	the	the	DET
ctmj-146	253	2	year	year	NOUN
ctmj-146	253	3	2007;569(1‒2):103e109	2007;569(1‒2):103e109	NUM
ctmj-146	253	4	.	.	PUNCT
ctmj-146	254	1	28.our	28.our	NUM
ctmj-146	254	2	group	group	NOUN
ctmj-146	254	3	includes	include	VERB
ctmj-146	254	4	jiang	jiang	PROPN
ctmj-146	254	5	zh	zh	PROPN
ctmj-146	254	6	,	,	PUNCT
ctmj-146	254	7	fu	fu	NOUN
ctmj-146	254	8	ly	ly	ADP
ctmj-146	254	9	,	,	PUNCT
ctmj-146	254	10	xu	xu	PROPN
ctmj-146	254	11	yn	yn	PROPN
ctmj-146	254	12	,	,	PUNCT
ctmj-146	254	13	and	and	CCONJ
ctmj-146	254	14	others	other	NOUN
ctmj-146	254	15	.	.	PUNCT
ctmj-146	255	1	cyclovirobuxine	cyclovirobuxine	PROPN
ctmj-146	255	2	d	d	PROPN
ctmj-146	255	3	prevents	prevent	VERB
ctmj-146	255	4	diabetes	diabetes	NOUN
ctmj-146	255	5	complications	complication	NOUN
ctmj-146	255	6	myopathy	myopathy	ADJ
ctmj-146	255	7	caused	cause	VERB
ctmj-146	255	8	by	by	ADP
ctmj-146	255	9	diuretics	diuretic	NOUN
ctmj-146	255	10	via	via	ADP
ctmj-146	255	11	triggering	trigger	VERB
ctmj-146	255	12	antioxidant	antioxidant	ADJ
ctmj-146	255	13	responses	response	NOUN
ctmj-146	255	14	mediated	mediate	VERB
ctmj-146	255	15	by	by	ADP
ctmj-146	255	16	nrf	nrf	NOUN
ctmj-146	255	17	2	2	NUM
ctmj-146	255	18	.	.	PUNCT
ctmj-146	255	19	science	science	NOUN
ctmj-146	255	20	reports	report	NOUN
ctmj-146	255	21	,	,	PUNCT
ctmj-146	255	22	2020	2020	NUM
ctmj-146	255	23	,	,	PUNCT
ctmj-146	255	24	10	10	NUM
ctmj-146	255	25	,	,	PUNCT
ctmj-146	255	26	6427	6427	NUM
ctmj-146	255	27	.	.	PUNCT
ctmj-146	256	1	29.members	29.member	NOUN
ctmj-146	256	2	of	of	ADP
ctmj-146	256	3	the	the	DET
ctmj-146	256	4	research	research	NOUN
ctmj-146	256	5	team	team	NOUN
ctmj-146	256	6	:	:	PUNCT
ctmj-146	256	7	guo	guo	PROPN
ctmj-146	256	8	q	q	PROPN
ctmj-146	256	9	,	,	PUNCT
ctmj-146	256	10	guo	guo	PROPN
ctmj-146	256	11	jb	jb	PROPN
ctmj-146	256	12	,	,	PUNCT
ctmj-146	256	13	yang	yang	PROPN
ctmj-146	256	14	r	r	PROPN
ctmj-146	256	15	,	,	PUNCT
ctmj-146	256	16	and	and	CCONJ
ctmj-146	256	17	others	other	NOUN
ctmj-146	256	18	.	.	PUNCT
ctmj-146	257	1	to	to	PART
ctmj-146	257	2	reduce	reduce	VERB
ctmj-146	257	3	doxorubicininduced	doxorubicininduce	VERB
ctmj-146	257	4	cardiomyopathy	cardiomyopathy	ADJ
ctmj-146	257	5	,	,	PUNCT
ctmj-146	257	6	cyclovirbuxine	cyclovirbuxine	NOUN
ctmj-146	257	7	d	d	NOUN
ctmj-146	257	8	inhibits	inhibit	VERB
ctmj-146	257	9	mitochondrial	mitochondrial	ADJ
ctmj-146	257	10	biogenesis	biogenesis	NOUN
ctmj-146	257	11	and	and	CCONJ
ctmj-146	257	12	oxidative	oxidative	ADJ
ctmj-146	257	13	damage	damage	NOUN
ctmj-146	257	14	.	.	PUNCT
ctmj-146	258	1	how	how	SCONJ
ctmj-146	258	2	long	long	ADV
ctmj-146	258	3	does	do	AUX
ctmj-146	258	4	oxidative	oxidative	VERB
ctmj-146	258	5	stress	stress	NOUN
ctmj-146	258	6	on	on	ADP
ctmj-146	258	7	medical	medical	ADJ
ctmj-146	258	8	cells	cell	NOUN
ctmj-146	258	9	last	last	ADJ
ctmj-146	258	10	?	?	PUNCT
ctmj-146	259	1	publication	publication	NOUN
ctmj-146	259	2	year	year	NOUN
ctmj-146	259	3	2015;2015:151972	2015;2015:151972	NUM
ctmj-146	259	4	.	.	PUNCT
ctmj-146	260	1	30.this	30.this	DET
ctmj-146	260	2	work	work	NOUN
ctmj-146	260	3	is	be	AUX
ctmj-146	260	4	by	by	ADP
ctmj-146	260	5	xiang	xiang	PROPN
ctmj-146	260	6	zn	zn	PROPN
ctmj-146	260	7	,	,	PUNCT
ctmj-146	260	8	yi	yi	PROPN
ctmj-146	260	9	wq	wq	PROPN
ctmj-146	260	10	,	,	PUNCT
ctmj-146	260	11	wang	wang	PROPN
ctmj-146	260	12	yl	yl	NOUN
ctmj-146	260	13	,	,	PUNCT
ctmj-146	260	14	and	and	CCONJ
ctmj-146	260	15	others	other	NOUN
ctmj-146	260	16	.	.	PUNCT
ctmj-146	261	1	efficacy	efficacy	NOUN
ctmj-146	261	2	of	of	ADP
ctmj-146	261	3	17(13/18	17(13/18	PROPN
ctmj-146	261	4	)	)	PUNCT
ctmj-146	261	5	abeocycloartenol	abeocycloartenol	NOUN
ctmj-146	261	6	triterpenoidal	triterpenoidal	NOUN
ctmj-146	261	7	alkaloids	alkaloid	NOUN
ctmj-146	261	8	derived	derive	VERB
ctmj-146	261	9	from	from	ADP
ctmj-146	261	10	buxus	buxus	NOUN
ctmj-146	261	11	austro	austro	NOUN
ctmj-146	261	12	-	-	PUNCT
ctmj-146	261	13	yunnanensis	yunnanensis	NOUN
ctmj-146	261	14	in	in	ADP
ctmj-146	261	15	preventing	prevent	VERB
ctmj-146	261	16	cardiac	cardiac	ADJ
ctmj-146	261	17	damage	damage	NOUN
ctmj-146	261	18	(	(	PUNCT
ctmj-146	261	19	buxaustroines	buxaustroine	NOUN
ctmj-146	261	20	a	a	PRON
ctmj-146	261	21	–	–	PUNCT
ctmj-146	261	22	n	n	NUM
ctmj-146	261	23	)	)	PUNCT
ctmj-146	261	24	.	.	PUNCT
ctmj-146	262	1	biological	biological	ADJ
ctmj-146	262	2	products	product	NOUN
ctmj-146	262	3	journal	journal	NOUN
ctmj-146	262	4	.	.	PUNCT
ctmj-146	263	1	the	the	DET
ctmj-146	263	2	current	current	ADJ
ctmj-146	263	3	version	version	NOUN
ctmj-146	263	4	is	be	AUX
ctmj-146	263	5	2019	2019	NUM
ctmj-146	263	6	at	at	ADP
ctmj-146	263	7	82(11):3111e3120	82(11):3111e3120	NUM
ctmj-146	263	8	.	.	PUNCT
ctmj-146	264	1	page	page	NOUN
ctmj-146	264	2	31.everyone	31.everyone	NUM
ctmj-146	264	3	from	from	ADP
ctmj-146	264	4	saleem	saleem	PROPN
ctmj-146	264	5	h	h	PROPN
ctmj-146	264	6	to	to	PART
ctmj-146	264	7	htar	htar	VERB
ctmj-146	264	8	tt	tt	PROPN
ctmj-146	264	9	and	and	CCONJ
ctmj-146	264	10	naidu	naidu	PROPN
ctmj-146	264	11	r	r	NOUN
ctmj-146	264	12	must	must	AUX
ctmj-146	264	13	be	be	AUX
ctmj-146	264	14	included	include	VERB
ctmj-146	264	15	.	.	PUNCT
ctmj-146	265	1	the	the	DET
ctmj-146	265	2	medicinal	medicinal	ADJ
ctmj-146	265	3	value	value	NOUN
ctmj-146	265	4	of	of	ADP
ctmj-146	265	5	buxus	buxus	NOUN
ctmj-146	265	6	papillosa	papillosa	PROPN
ctmj-146	265	7	c.k	c.k	PROPN
ctmj-146	265	8	.	.	PROPN
ctmj-146	265	9	's	's	PART
ctmj-146	265	10	aerial	aerial	ADJ
ctmj-146	265	11	and	and	CCONJ
ctmj-146	265	12	stem	stem	NOUN
ctmj-146	265	13	components	component	NOUN
ctmj-146	265	14	.	.	PUNCT
ctmj-146	266	1	chemical	chemical	ADJ
ctmj-146	266	2	,	,	PUNCT
ctmj-146	266	3	biological	biological	ADJ
ctmj-146	266	4	,	,	PUNCT
ctmj-146	266	5	and	and	CCONJ
ctmj-146	266	6	toxicological	toxicological	ADJ
ctmj-146	266	7	viewpoints	viewpoint	NOUN
ctmj-146	266	8	from	from	ADP
ctmj-146	266	9	in	in	ADP
ctmj-146	266	10	vitro	vitro	X
ctmj-146	266	11	studies	study	NOUN
ctmj-146	266	12	(	(	PUNCT
ctmj-146	266	13	schneid	schneid	ADV
ctmj-146	266	14	)	)	PUNCT
ctmj-146	266	15	.	.	PUNCT
ctmj-146	267	1	the	the	DET
ctmj-146	267	2	journal	journal	NOUN
ctmj-146	267	3	of	of	ADP
ctmj-146	267	4	pharmaceutical	pharmaceutical	ADJ
ctmj-146	267	5	biomedical	biomedical	ADJ
ctmj-146	267	6	analysis	analysis	NOUN
ctmj-146	267	7	.	.	PUNCT
ctmj-146	268	1	128–138	128–138	NUM
ctmj-146	268	2	(	(	PUNCT
ctmj-146	268	3	2019	2019	NUM
ctmj-146	268	4	,	,	PUNCT
ctmj-146	268	5	vol	vol	NOUN
ctmj-146	268	6	.	.	NOUN
ctmj-146	268	7	166	166	NUM
ctmj-146	268	8	)	)	PUNCT
ctmj-146	268	9	.	.	PUNCT
ctmj-146	269	1	32.investigation	32.investigation	NUM
ctmj-146	269	2	of	of	ADP
ctmj-146	269	3	the	the	DET
ctmj-146	269	4	possible	possible	ADJ
ctmj-146	269	5	anticancer	anticancer	NOUN
ctmj-146	269	6	effects	effect	NOUN
ctmj-146	269	7	of	of	ADP
ctmj-146	269	8	traditional	traditional	ADJ
ctmj-146	269	9	yemeni	yemeni	ADJ
ctmj-146	269	10	medicinal	medicinal	ADJ
ctmj-146	269	11	herbs	herb	NOUN
ctmj-146	269	12	(	(	PUNCT
ctmj-146	269	13	mothana	mothana	PROPN
ctmj-146	269	14	ra	ra	PROPN
ctmj-146	269	15	,	,	PUNCT
ctmj-146	269	16	grünert	grünert	ADJ
ctmj-146	269	17	r	r	NOUN
ctmj-146	269	18	,	,	PUNCT
ctmj-146	269	19	lindequist	lindequist	NOUN
ctmj-146	269	20	u	u	PROPN
ctmj-146	269	21	,	,	PUNCT
ctmj-146	269	22	bednarski	bednarski	NOUN
ctmj-146	269	23	pj	pj	PROPN
ctmj-146	269	24	)	)	PUNCT
ctmj-146	269	25	.	.	PUNCT
ctmj-146	270	1	pharmazie	pharmazie	PROPN
ctmj-146	270	2	.	.	PUNCT
ctmj-146	271	1	in	in	ADP
ctmj-146	271	2	2007;62(4	2007;62(4	NUM
ctmj-146	271	3	):	):	PUNCT
ctmj-146	271	4	305–307	305–307	NUM
ctmj-146	271	5	.	.	PUNCT
ctmj-146	272	1	no	no	INTJ
ctmj-146	272	2	.	.	PUNCT
ctmj-146	273	1	33.authors	33.authors	NUM
ctmj-146	273	2	:	:	PUNCT
ctmj-146	273	3	ait	ait	X
ctmj-146	273	4	-	-	PUNCT
ctmj-146	273	5	mohamed	mohamed	PROPN
ctmj-146	273	6	o	o	PROPN
ctmj-146	273	7	,	,	PUNCT
ctmj-146	273	8	battisti	battisti	PROPN
ctmj-146	273	9	v	v	NOUN
ctmj-146	273	10	,	,	PUNCT
ctmj-146	273	11	joliot	joliot	NOUN
ctmj-146	273	12	v	v	NOUN
ctmj-146	273	13	,	,	PUNCT
ctmj-146	273	14	and	and	CCONJ
ctmj-146	273	15	others	other	NOUN
ctmj-146	273	16	.	.	PUNCT
ctmj-146	274	1	buxus	buxus	PROPN
ctmj-146	274	2	sempervirens	semperviren	NOUN
ctmj-146	274	3	acetonic	acetonic	ADJ
ctmj-146	274	4	extract	extract	NOUN
ctmj-146	274	5	causes	cause	VERB
ctmj-146	274	6	breast	breast	NOUN
ctmj-146	274	7	cancer	cancer	NOUN
ctmj-146	274	8	cells	cell	NOUN
ctmj-146	274	9	to	to	PART
ctmj-146	274	10	undergo	undergo	VERB
ctmj-146	274	11	cell	cell	NOUN
ctmj-146	274	12	cycle	cycle	NOUN
ctmj-146	274	13	arrest	arrest	NOUN
ctmj-146	274	14	,	,	PUNCT
ctmj-146	274	15	apoptosis	apoptosis	NOUN
ctmj-146	274	16	,	,	PUNCT
ctmj-146	274	17	and	and	CCONJ
ctmj-146	274	18	autophagy	autophagy	NOUN
ctmj-146	274	19	.	.	PUNCT
ctmj-146	275	1	the	the	DET
ctmj-146	275	2	journal	journal	PROPN
ctmj-146	275	3	plos	plo	VERB
ctmj-146	275	4	one	one	NUM
ctmj-146	275	5	.	.	PUNCT
ctmj-146	276	1	2011	2011	NUM
ctmj-146	276	2	,	,	PUNCT
ctmj-146	276	3	volume	volume	NOUN
ctmj-146	276	4	6	6	NUM
ctmj-146	276	5	,	,	PUNCT
ctmj-146	276	6	issue	issue	NOUN
ctmj-146	276	7	9	9	NUM
ctmj-146	276	8	,	,	PUNCT
ctmj-146	276	9	page	page	NOUN
ctmj-146	276	10	e24537	e24537	PROPN
ctmj-146	276	11	.	.	PUNCT
ctmj-146	277	1	34.terpenoid	34.terpenoid	NUM
ctmj-146	277	2	alkaloids	alkaloid	NOUN
ctmj-146	277	3	from	from	ADP
ctmj-146	277	4	the	the	DET
ctmj-146	277	5	buxaceae	buxaceae	ADJ
ctmj-146	277	6	family	family	NOUN
ctmj-146	277	7	that	that	PRON
ctmj-146	277	8	may	may	AUX
ctmj-146	277	9	have	have	VERB
ctmj-146	277	10	biological	biological	ADJ
ctmj-146	277	11	significance	significance	NOUN
ctmj-146	277	12	(	(	PUNCT
ctmj-146	277	13	devkota	devkota	PROPN
ctmj-146	277	14	kp	kp	PROPN
ctmj-146	277	15	,	,	PUNCT
ctmj-146	277	16	lenta	lenta	PROPN
ctmj-146	277	17	bn	bn	PROPN
ctmj-146	277	18	,	,	PUNCT
ctmj-146	277	19	fokou	fokou	PROPN
ctmj-146	277	20	pa	pa	PROPN
ctmj-146	277	21	,	,	PUNCT
ctmj-146	277	22	sewald	sewald	ADJ
ctmj-146	277	23	n.	n.	NOUN
ctmj-146	277	24	)	)	PUNCT
ctmj-146	277	25	.	.	PUNCT
ctmj-146	278	1	article	article	NOUN
ctmj-146	278	2	published	publish	VERB
ctmj-146	278	3	in	in	ADP
ctmj-146	278	4	2008	2008	NUM
ctmj-146	278	5	in	in	ADP
ctmj-146	278	6	the	the	DET
ctmj-146	278	7	national	national	PROPN
ctmj-146	278	8	productivity	productivity	PROPN
ctmj-146	278	9	report	report	NOUN
ctmj-146	278	10	,	,	PUNCT
ctmj-146	278	11	volume	volume	NOUN
ctmj-146	278	12	25	25	NUM
ctmj-146	278	13	,	,	PUNCT
ctmj-146	278	14	issue	issue	NOUN
ctmj-146	278	15	3	3	NUM
ctmj-146	278	16	,	,	PUNCT
ctmj-146	278	17	pages	page	NOUN
ctmj-146	278	18	612–630	612–630	NUM
ctmj-146	278	19	.	.	PUNCT
ctmj-146	279	1	35.the	35.the	DET
ctmj-146	279	2	biology	biology	NOUN
ctmj-146	279	3	and	and	CCONJ
ctmj-146	279	4	chemistry	chemistry	NOUN
ctmj-146	279	5	of	of	ADP
ctmj-146	279	6	buxus	buxus	NOUN
ctmj-146	279	7	steroidal	steroidal	NOUN
ctmj-146	279	8	alkaloids	alkaloid	NOUN
ctmj-146	279	9	(	(	PUNCT
ctmj-146	279	10	ata	ata	INTJ
ctmj-146	279	11	a	a	PRON
ctmj-146	279	12	,	,	PUNCT
ctmj-146	279	13	andersh	andersh	ADJ
ctmj-146	279	14	bj	bj	NOUN
ctmj-146	279	15	)	)	PUNCT
ctmj-146	279	16	.	.	PUNCT
ctmj-146	280	1	chemistry	chemistry	NOUN
ctmj-146	280	2	and	and	CCONJ
ctmj-146	280	3	biological	biological	ADJ
ctmj-146	280	4	sciences	science	NOUN
ctmj-146	280	5	includes	include	VERB
ctmj-146	280	6	alkaloids	alkaloid	NOUN
ctmj-146	280	7	.	.	PUNCT
ctmj-146	281	1	in	in	ADP
ctmj-146	281	2	2008	2008	NUM
ctmj-146	281	3	,	,	PUNCT
ctmj-146	281	4	vol	vol	NOUN
ctmj-146	281	5	.	.	PROPN
ctmj-146	281	6	66	66	NUM
ctmj-146	281	7	,	,	PUNCT
ctmj-146	281	8	pages	page	NOUN
ctmj-146	281	9	191–213	191–213	NUM
ctmj-146	281	10	.	.	PUNCT
ctmj-146	282	1	36.in	36.in	NUM
ctmj-146	282	2	a	a	DET
ctmj-146	282	3	study	study	NOUN
ctmj-146	282	4	conducted	conduct	VERB
ctmj-146	282	5	by	by	ADP
ctmj-146	282	6	althaus	althaus	PROPN
ctmj-146	282	7	et	et	PROPN
ctmj-146	282	8	al	al	PROPN
ctmj-146	282	9	.	.	PROPN
ctmj-146	282	10	,	,	PUNCT
ctmj-146	282	11	antiprotozoal	antiprotozoal	ADJ
ctmj-146	282	12	activity	activity	NOUN
ctmj-146	282	13	of	of	ADP
ctmj-146	282	14	buxus	buxus	NOUN
ctmj-146	282	15	sempervirens	semperviren	NOUN
ctmj-146	282	16	was	be	AUX
ctmj-146	282	17	investigated	investigate	VERB
ctmj-146	282	18	.	.	PUNCT
ctmj-146	283	1	the	the	DET
ctmj-146	283	2	authors	author	NOUN
ctmj-146	283	3	identified	identify	VERB
ctmj-146	283	4	otigloylcyclovirobuxeine	otigloylcyclovirobuxeine	NOUN
ctmj-146	283	5	-	-	PUNCT
ctmj-146	283	6	b	b	NOUN
ctmj-146	283	7	as	as	ADP
ctmj-146	283	8	the	the	DET
ctmj-146	283	9	primary	primary	ADJ
ctmj-146	283	10	component	component	NOUN
ctmj-146	283	11	that	that	PRON
ctmj-146	283	12	inhibited	inhibit	VERB
ctmj-146	283	13	plasmodium	plasmodium	NOUN
ctmj-146	283	14	falciparum	falciparum	ADJ
ctmj-146	283	15	infection	infection	NOUN
ctmj-146	283	16	.	.	PUNCT
ctmj-146	284	1	small	small	ADJ
ctmj-146	284	2	biological	biological	ADJ
ctmj-146	284	3	units	unit	NOUN
ctmj-146	284	4	.	.	PUNCT
ctmj-146	285	1	published	publish	VERB
ctmj-146	285	2	in	in	ADP
ctmj-146	285	3	2014	2014	NUM
ctmj-146	285	4	,	,	PUNCT
ctmj-146	285	5	volume	volume	NOUN
ctmj-146	285	6	19	19	NUM
ctmj-146	285	7	,	,	PUNCT
ctmj-146	285	8	issue	issue	NOUN
ctmj-146	285	9	5	5	NUM
ctmj-146	285	10	,	,	PUNCT
ctmj-146	285	11	pages	page	NOUN
ctmj-146	285	12	6184–6201	6184–6201	NUM
ctmj-146	285	13	.	.	PUNCT
ctmj-146	286	1	37.a	37.a	NUM
ctmj-146	286	2	3d	3d	NUM
ctmj-146	286	3	-	-	PUNCT
ctmj-146	286	4	qsar	qsar	NOUN
ctmj-146	286	5	investigation	investigation	NOUN
ctmj-146	286	6	on	on	ADP
ctmj-146	286	7	the	the	DET
ctmj-146	286	8	antitrypanosomal	antitrypanosomal	ADJ
ctmj-146	286	9	and	and	CCONJ
ctmj-146	286	10	cytotoxic	cytotoxic	ADJ
ctmj-146	286	11	effects	effect	NOUN
ctmj-146	286	12	of	of	ADP
ctmj-146	286	13	steroid	steroid	NOUN
ctmj-146	286	14	alkaloids	alkaloid	NOUN
ctmj-146	286	15	by	by	ADP
ctmj-146	286	16	comparative	comparative	ADJ
ctmj-146	286	17	molecular	molecular	ADJ
ctmj-146	286	18	field	field	NOUN
ctmj-146	286	19	analysis	analysis	NOUN
ctmj-146	286	20	was	be	AUX
ctmj-146	286	21	conducted	conduct	VERB
ctmj-146	286	22	by	by	ADP
ctmj-146	286	23	nnadi	nnadi	PROPN
ctmj-146	286	24	co	co	PROPN
ctmj-146	286	25	,	,	PUNCT
ctmj-146	286	26	althaus	althaus	PROPN
ctmj-146	286	27	jb	jb	PROPN
ctmj-146	286	28	,	,	PUNCT
ctmj-146	286	29	nwodo	nwodo	PROPN
ctmj-146	286	30	nj	nj	PROPN
ctmj-146	286	31	,	,	PUNCT
ctmj-146	286	32	and	and	CCONJ
ctmj-146	286	33	schmidt	schmidt	PROPN
ctmj-146	286	34	tj	tj	PROPN
ctmj-146	286	35	.	.	PROPN
ctmj-146	286	36	small	small	ADJ
ctmj-146	286	37	biological	biological	ADJ
ctmj-146	286	38	units	unit	NOUN
ctmj-146	286	39	.	.	PUNCT
ctmj-146	287	1	published	publish	VERB
ctmj-146	287	2	in	in	ADP
ctmj-146	287	3	2018	2018	NUM
ctmj-146	287	4	with	with	ADP
ctmj-146	287	5	the	the	DET
ctmj-146	287	6	doi	doi	NOUN
ctmj-146	287	7	number	number	NOUN
ctmj-146	287	8	23551113	23551113	NUM
ctmj-146	287	9	.	.	PUNCT
ctmj-146	288	1	38.by	38.by	PROPN
ctmj-146	288	2	ata	ata	PROPN
ctmj-146	288	3	a	a	PRON
ctmj-146	288	4	,	,	PUNCT
ctmj-146	288	5	iverson	iverson	PROPN
ctmj-146	288	6	cd	cd	PROPN
ctmj-146	288	7	,	,	PUNCT
ctmj-146	288	8	kalhari	kalhari	PROPN
ctmj-146	288	9	ks	ks	PROPN
ctmj-146	288	10	,	,	PUNCT
ctmj-146	288	11	and	and	CCONJ
ctmj-146	288	12	colleagues	colleague	NOUN
ctmj-146	288	13	.	.	PUNCT
ctmj-146	289	1	benzoyl	benzoyl	NOUN
ctmj-146	289	2	alkaloids	alkaloid	NOUN
ctmj-146	289	3	derived	derive	VERB
ctmj-146	289	4	from	from	ADP
ctmj-146	289	5	buxus	buxus	PROPN
ctmj-146	289	6	hyrcana	hyrcana	PROPN
ctmj-146	289	7	and	and	CCONJ
ctmj-146	289	8	their	their	PRON
ctmj-146	289	9	effects	effect	NOUN
ctmj-146	289	10	on	on	ADP
ctmj-146	289	11	enzyme	enzyme	NOUN
ctmj-146	289	12	inhibition	inhibition	NOUN
ctmj-146	289	13	,	,	PUNCT
ctmj-146	289	14	antifungal	antifungal	ADJ
ctmj-146	289	15	,	,	PUNCT
ctmj-146	289	16	and	and	CCONJ
ctmj-146	289	17	antileishmanial	antileishmanial	ADJ
ctmj-146	289	18	parasites	parasite	NOUN
ctmj-146	289	19	.	.	PUNCT
ctmj-146	290	1	science	science	NOUN
ctmj-146	290	2	of	of	ADP
ctmj-146	290	3	plants	plant	NOUN
ctmj-146	290	4	.	.	PUNCT
ctmj-146	291	1	2010	2010	NUM
ctmj-146	291	2	,	,	PUNCT
ctmj-146	291	3	volume	volume	NOUN
ctmj-146	291	4	71	71	NUM
ctmj-146	291	5	,	,	PUNCT
ctmj-146	291	6	issues	issue	NOUN
ctmj-146	291	7	14–15	14–15	NUM
ctmj-146	291	8	,	,	PUNCT
ctmj-146	291	9	pages	page	NOUN
ctmj-146	291	10	1780–1786	1780–1786	NUM
ctmj-146	291	11	.	.	PUNCT
ctmj-146	292	1	39.choudhary	39.choudhary	NUM
ctmj-146	292	2	mi	mi	PROPN
ctmj-146	292	3	,	,	PUNCT
ctmj-146	292	4	khalid	khalid	PROPN
ctmj-146	292	5	a	a	PROPN
ctmj-146	292	6	,	,	PUNCT
ctmj-146	292	7	parveen	parveen	PROPN
ctmj-146	292	8	s	s	PROPN
ctmj-146	292	9	,	,	PUNCT
ctmj-146	292	10	atta	atta	PROPN
ctmj-146	292	11	-	-	PUNCT
ctmj-146	292	12	urrahman	urrahman	ADJ
ctmj-146	292	13	,	,	PUNCT
ctmj-146	292	14	azim	azim	PROPN
ctmj-146	292	15	mk	mk	PROPN
ctmj-146	292	16	the	the	DET
ctmj-146	292	17	triterpenoidal	triterpenoidal	NOUN
ctmj-146	292	18	alkaloids	alkaloid	NOUN
ctmj-146	292	19	'	'	PART
ctmj-146	292	20	ability	ability	NOUN
ctmj-146	292	21	to	to	PART
ctmj-146	292	22	inhibit	inhibit	VERB
ctmj-146	292	23	acetylcholinesterase	acetylcholinesterase	NOUN
ctmj-146	292	24	.	.	PUNCT
ctmj-146	293	1	the	the	DET
ctmj-146	293	2	journal	journal	PROPN
ctmj-146	293	3	biochemistry	biochemistry	NOUN
ctmj-146	293	4	and	and	CCONJ
ctmj-146	293	5	biophysics	biophysic	NOUN
ctmj-146	293	6	research	research	NOUN
ctmj-146	293	7	communications	communication	NOUN
ctmj-146	293	8	.	.	PUNCT
ctmj-146	294	1	journal	journal	PROPN
ctmj-146	294	2	article	article	NOUN
ctmj-146	294	3	:	:	PUNCT
ctmj-146	294	4	2005;331(4	2005;331(4	NUM
ctmj-146	294	5	):	):	PUNCT
ctmj-146	294	6	1528–1532	1528–1532	NUM
ctmj-146	294	7	.	.	PUNCT
ctmj-146	295	1	40.authors	40.authors	NUM
ctmj-146	295	2	:	:	PUNCT
ctmj-146	295	3	choudhary	choudhary	PROPN
ctmj-146	295	4	mi	mi	PROPN
ctmj-146	295	5	,	,	PUNCT
ctmj-146	295	6	shahnaz	shahnaz	PROPN
ctmj-146	295	7	s	s	PROPN
ctmj-146	295	8	,	,	PUNCT
ctmj-146	295	9	parveen	parveen	PROPN
ctmj-146	295	10	s	s	PART
ctmj-146	295	11	,	,	PUNCT
ctmj-146	295	12	and	and	CCONJ
ctmj-146	295	13	others	other	NOUN
ctmj-146	295	14	.	.	PUNCT
ctmj-146	296	1	triterpenoid	triterpenoid	VERB
ctmj-146	296	2	alkaloids	alkaloid	NOUN
ctmj-146	296	3	produced	produce	VERB
ctmj-146	296	4	by	by	ADP
ctmj-146	296	5	buxus	buxus	PROPN
ctmj-146	296	6	hyrcana	hyrcana	PROPN
ctmj-146	296	7	that	that	SCONJ
ctmj-146	296	8	inhibit	inhibit	NOUN
ctmj-146	296	9	cholinesterase	cholinesterase	NOUN
ctmj-146	296	10	are	be	AUX
ctmj-146	296	11	novel	novel	ADJ
ctmj-146	296	12	compounds	compound	NOUN
ctmj-146	296	13	.	.	PUNCT
ctmj-146	297	1	organic	organic	ADJ
ctmj-146	297	2	biodiversity	biodiversity	NOUN
ctmj-146	297	3	.	.	PUNCT
ctmj-146	298	1	published	publish	VERB
ctmj-146	298	2	in	in	ADP
ctmj-146	298	3	2006	2006	NUM
ctmj-146	298	4	,	,	PUNCT
ctmj-146	298	5	volume	volume	NOUN
ctmj-146	298	6	3	3	NUM
ctmj-146	298	7	,	,	PUNCT
ctmj-146	298	8	issue	issue	NOUN
ctmj-146	298	9	9	9	NUM
ctmj-146	298	10	,	,	PUNCT
ctmj-146	298	11	pages	page	NOUN
ctmj-146	298	12	1039–1052	1039–1052	NUM
ctmj-146	298	13	.	.	PUNCT
ctmj-146	299	1	41.the	41.the	DET
ctmj-146	299	2	bioactive	bioactive	ADJ
ctmj-146	299	3	steroidal	steroidal	NOUN
ctmj-146	299	4	alkaloids	alkaloid	NOUN
ctmj-146	299	5	derived	derive	VERB
ctmj-146	299	6	from	from	ADP
ctmj-146	299	7	buxus	buxus	PROPN
ctmj-146	299	8	macowanii	macowanii	PROPN
ctmj-146	299	9	oliv	oliv	NOUN
ctmj-146	299	10	.	.	PUNCT
ctmj-146	300	1	were	be	AUX
ctmj-146	300	2	studied	study	VERB
ctmj-146	300	3	by	by	ADP
ctmj-146	300	4	lam	lam	PROPN
ctmj-146	300	5	cw	cw	PROPN
ctmj-146	300	6	,	,	PUNCT
ctmj-146	300	7	wakeman	wakeman	PROPN
ctmj-146	300	8	a	a	PROPN
ctmj-146	300	9	,	,	PUNCT
ctmj-146	300	10	james	james	PROPN
ctmj-146	300	11	a	a	PROPN
ctmj-146	300	12	,	,	PUNCT
ctmj-146	300	13	ata	ata	X
ctmj-146	300	14	a	a	DET
ctmj-146	300	15	,	,	PUNCT
ctmj-146	300	16	gengan	gengan	PROPN
ctmj-146	300	17	rm	rm	PROPN
ctmj-146	300	18	,	,	PUNCT
ctmj-146	300	19	and	and	CCONJ
ctmj-146	300	20	ross	ross	PROPN
ctmj-146	300	21	sa	sa	PROPN
ctmj-146	300	22	.	.	PUNCT
ctmj-146	301	1	anabolic	anabolic	PROPN
ctmj-146	301	2	steroids	steroid	NOUN
ctmj-146	301	3	.	.	PUNCT
ctmj-146	302	1	publication	publication	NOUN
ctmj-146	302	2	date	date	NOUN
ctmj-146	302	3	:	:	PUNCT
ctmj-146	302	4	2015;95:73–79	2015;95:73–79	NUM
ctmj-146	302	5	.	.	PUNCT
ctmj-146	303	1	42.it	42.it	NUM
ctmj-146	303	2	was	be	AUX
ctmj-146	303	3	written	write	VERB
ctmj-146	303	4	by	by	ADP
ctmj-146	303	5	wang	wang	PROPN
ctmj-146	303	6	yl	yl	PROPN
ctmj-146	303	7	,	,	PUNCT
ctmj-146	303	8	wu	wu	PROPN
ctmj-146	303	9	w	w	PROPN
ctmj-146	303	10	,	,	PUNCT
ctmj-146	303	11	su	su	PROPN
ctmj-146	303	12	yn	yn	PROPN
ctmj-146	303	13	,	,	PUNCT
ctmj-146	303	14	and	and	CCONJ
ctmj-146	303	15	others	other	NOUN
ctmj-146	303	16	.	.	PUNCT
ctmj-146	304	1	the	the	DET
ctmj-146	304	2	buxus	buxus	PROPN
ctmj-146	304	3	alkaloid	alkaloid	PROPN
ctmj-146	304	4	chemical	chemical	PROPN
ctmj-146	304	5	inhibits	inhibit	VERB
ctmj-146	304	6	the	the	DET
ctmj-146	304	7	hsf1	hsf1	PROPN
ctmj-146	304	8	chaperone	chaperone	PROPN
ctmj-146	304	9	axis	axis	NOUN
ctmj-146	304	10	,	,	PUNCT
ctmj-146	304	11	which	which	PRON
ctmj-146	304	12	in	in	ADP
ctmj-146	304	13	turn	turn	NOUN
ctmj-146	304	14	destabilizes	destabilize	VERB
ctmj-146	304	15	mutant	mutant	ADJ
ctmj-146	304	16	p53	p53	NOUN
ctmj-146	304	17	.	.	PUNCT
ctmj-146	305	1	herbal	herbal	ADJ
ctmj-146	305	2	medicine	medicine	NOUN
ctmj-146	305	3	.	.	PUNCT
ctmj-146	306	1	the	the	DET
ctmj-146	306	2	year	year	NOUN
ctmj-146	306	3	2020;68	2020;68	NOUN
ctmj-146	306	4	:	:	PUNCT
ctmj-146	306	5	153187	153187	NUM
ctmj-146	306	6	.	.	PUNCT
ctmj-146	307	1	43."neitzel	43."neitzel	ADJ
ctmj-146	307	2	c	c	NOUN
ctmj-146	307	3	,	,	PUNCT
ctmj-146	307	4	"	"	PUNCT
ctmj-146	307	5	"	"	PUNCT
ctmj-146	307	6	seiwert	seiwert	NOUN
ctmj-146	307	7	n	n	CCONJ
ctmj-146	307	8	,	,	PUNCT
ctmj-146	307	9	"	"	PUNCT
ctmj-146	307	10	"	"	PUNCT
ctmj-146	307	11	go€der	go€der	NOUN
ctmj-146	307	12	a	a	NOUN
ctmj-146	307	13	,	,	PUNCT
ctmj-146	307	14	"	"	PUNCT
ctmj-146	307	15	and	and	CCONJ
ctmj-146	307	16	others	other	NOUN
ctmj-146	307	17	.	.	PUNCT
ctmj-146	308	1	by	by	ADP
ctmj-146	308	2	directing	direct	VERB
ctmj-146	308	3	proteasomal	proteasomal	ADJ
ctmj-146	308	4	degradation	degradation	NOUN
ctmj-146	308	5	of	of	ADP
ctmj-146	308	6	p53	p53	NOUN
ctmj-146	308	7	,	,	PUNCT
ctmj-146	308	8	lipoic	lipoic	ADJ
ctmj-146	308	9	acid	acid	NOUN
ctmj-146	308	10	works	work	NOUN
ctmj-146	308	11	in	in	ADP
ctmj-146	308	12	tandem	tandem	NOUN
ctmj-146	308	13	with	with	ADP
ctmj-146	308	14	antineoplastic	antineoplastic	ADJ
ctmj-146	308	15	medications	medication	NOUN
ctmj-146	308	16	to	to	PART
ctmj-146	308	17	treat	treat	VERB
ctmj-146	308	18	colorectal	colorectal	ADJ
ctmj-146	308	19	cancer	cancer	NOUN
ctmj-146	308	20	.	.	PUNCT
ctmj-146	309	1	the	the	DET
ctmj-146	309	2	cell	cell	NOUN
ctmj-146	309	3	.	.	PUNCT
ctmj-146	310	1	2019	2019	NUM
ctmj-146	310	2	.	.	PUNCT
ctmj-146	311	1	volume	volume	NOUN
ctmj-146	311	2	8	8	NUM
ctmj-146	311	3	,	,	PUNCT
ctmj-146	311	4	issue	issue	NOUN
ctmj-146	311	5	7	7	NUM
ctmj-146	311	6	,	,	PUNCT
ctmj-146	311	7	p.	p.	NOUN
ctmj-146	311	8	794	794	NUM
ctmj-146	311	9	.	.	PUNCT
ctmj-146	312	1	44.the	44.the	DET
ctmj-146	312	2	authors	author	NOUN
ctmj-146	312	3	of	of	ADP
ctmj-146	312	4	the	the	DET
ctmj-146	312	5	study	study	NOUN
ctmj-146	312	6	are	be	AUX
ctmj-146	312	7	zhang	zhang	PROPN
ctmj-146	312	8	sl	sl	PROPN
ctmj-146	312	9	,	,	PUNCT
ctmj-146	312	10	zhou	zhou	PROPN
ctmj-146	312	11	ll	ll	PROPN
ctmj-146	312	12	,	,	PUNCT
ctmj-146	312	13	hong	hong	PROPN
ctmj-146	312	14	b	b	PROPN
ctmj-146	312	15	,	,	PUNCT
ctmj-146	312	16	and	and	CCONJ
ctmj-146	312	17	others	other	NOUN
ctmj-146	312	18	.	.	PUNCT
ctmj-146	313	1	restoring	restore	VERB
ctmj-146	313	2	p53	p53	NOUN
ctmj-146	313	3	pathway	pathway	NOUN
ctmj-146	313	4	signaling	signal	VERB
ctmj-146	313	5	and	and	CCONJ
ctmj-146	313	6	therapeutic	therapeutic	ADJ
ctmj-146	313	7	effects	effect	NOUN
ctmj-146	313	8	against	against	ADP
ctmj-146	313	9	colorectal	colorectal	ADJ
ctmj-146	313	10	cancer	cancer	NOUN
ctmj-146	313	11	via	via	ADP
ctmj-146	313	12	p73	p73	NOUN
ctmj-146	313	13	activation	activation	NOUN
ctmj-146	313	14	and	and	CCONJ
ctmj-146	313	15	degradation	degradation	NOUN
ctmj-146	313	16	of	of	ADP
ctmj-146	313	17	mutant	mutant	ADJ
ctmj-146	313	18	p53	p53	NOUN
ctmj-146	313	19	is	be	AUX
ctmj-146	313	20	achieved	achieve	VERB
ctmj-146	313	21	by	by	ADP
ctmj-146	313	22	the	the	DET
ctmj-146	313	23	small	small	ADJ
ctmj-146	313	24	-	-	PUNCT
ctmj-146	313	25	molecule	molecule	NOUN
ctmj-146	313	26	nsc59984	nsc59984	NOUN
ctmj-146	313	27	.	.	PUNCT
ctmj-146	314	1	research	research	NOUN
ctmj-146	314	2	in	in	ADP
ctmj-146	314	3	cancer	cancer	NOUN
ctmj-146	314	4	.	.	PUNCT
ctmj-146	315	1	2015;75(18):3842e3852	2015;75(18):3842e3852	NOUN
ctmj-146	315	2	.	.	PUNCT
ctmj-146	316	1	45.with	45.with	NUM
ctmj-146	316	2	contributions	contribution	NOUN
ctmj-146	316	3	from	from	ADP
ctmj-146	316	4	tang	tang	PROPN
ctmj-146	316	5	f	f	PROPN
ctmj-146	316	6	,	,	PUNCT
ctmj-146	316	7	min	min	PROPN
ctmj-146	316	8	l	l	PROPN
ctmj-146	316	9	,	,	PUNCT
ctmj-146	316	10	seebacher	seebacher	NOUN
ctmj-146	316	11	na	na	NOUN
ctmj-146	316	12	,	,	PUNCT
ctmj-146	316	13	and	and	CCONJ
ctmj-146	316	14	colleagues	colleague	NOUN
ctmj-146	316	15	.	.	PUNCT
ctmj-146	317	1	one	one	NUM
ctmj-146	317	2	possible	possible	ADJ
ctmj-146	317	3	therapeutic	therapeutic	ADJ
ctmj-146	317	4	approach	approach	NOUN
ctmj-146	317	5	for	for	ADP
ctmj-146	317	6	treating	treat	VERB
ctmj-146	317	7	osteosarcoma	osteosarcoma	NOUN
ctmj-146	317	8	is	be	AUX
ctmj-146	317	9	to	to	PART
ctmj-146	317	10	target	target	VERB
ctmj-146	317	11	mutant	mutant	ADJ
ctmj-146	317	12	tp53	tp53	PROPN
ctmj-146	317	13	.	.	PUNCT
ctmj-146	318	1	the	the	DET
ctmj-146	318	2	citation	citation	NOUN
ctmj-146	318	3	is	be	AUX
ctmj-146	318	4	from	from	ADP
ctmj-146	318	5	the	the	DET
ctmj-146	318	6	journal	journal	NOUN
ctmj-146	318	7	of	of	ADP
ctmj-146	318	8	orthopaedic	orthopaedic	ADJ
ctmj-146	318	9	research	research	NOUN
ctmj-146	318	10	(	(	PUNCT
ctmj-146	318	11	2019	2019	NUM
ctmj-146	318	12	,	,	PUNCT
ctmj-146	318	13	volume	volume	NOUN
ctmj-146	318	14	37	37	NUM
ctmj-146	318	15	,	,	PUNCT
ctmj-146	318	16	issue	issue	NOUN
ctmj-146	318	17	3	3	NUM
ctmj-146	318	18	,	,	PUNCT
ctmj-146	318	19	pages	page	NOUN
ctmj-146	318	20	789–798	789–798	NUM
ctmj-146	318	21	)	)	PUNCT
ctmj-146	318	22	.	.	PUNCT
ctmj-146	319	1	46.by	46.by	NUM
ctmj-146	319	2	mesaik	mesaik	PROPN
ctmj-146	319	3	ma	ma	PROPN
ctmj-146	319	4	,	,	PUNCT
ctmj-146	319	5	halim	halim	PROPN
ctmj-146	319	6	sa	sa	PROPN
ctmj-146	319	7	,	,	PUNCT
ctmj-146	319	8	ul	ul	PROPN
ctmj-146	319	9	-	-	ADJ
ctmj-146	319	10	haq	haq	PROPN
ctmj-146	319	11	z	z	PROPN
ctmj-146	319	12	,	,	PUNCT
ctmj-146	319	13	and	and	CCONJ
ctmj-146	319	14	colleagues	colleague	NOUN
ctmj-146	319	15	.	.	PUNCT
ctmj-146	320	1	buxidin	buxidin	VERB
ctmj-146	320	2	and	and	CCONJ
ctmj-146	320	3	e	e	NOUN
ctmj-146	320	4	-	-	NOUN
ctmj-146	320	5	buxenone	buxenone	ADJ
ctmj-146	320	6	,	,	PUNCT
ctmj-146	320	7	two	two	NUM
ctmj-146	320	8	components	component	NOUN
ctmj-146	320	9	of	of	ADP
ctmj-146	320	10	buxus	buxus	NOUN
ctmj-146	320	11	hyrcana	hyrcana	PROPN
ctmj-146	320	12	,	,	PUNCT
ctmj-146	320	13	have	have	VERB
ctmj-146	320	14	an	an	DET
ctmj-146	320	15	immunosuppressive	immunosuppressive	ADJ
ctmj-146	320	16	effect	effect	NOUN
ctmj-146	320	17	.	.	PUNCT
ctmj-146	321	1	science	science	NOUN
ctmj-146	321	2	of	of	ADP
ctmj-146	321	3	molecular	molecular	ADJ
ctmj-146	321	4	biology	biology	NOUN
ctmj-146	321	5	and	and	CCONJ
ctmj-146	321	6	drug	drug	NOUN
ctmj-146	321	7	discovery	discovery	NOUN
ctmj-146	321	8	.	.	PUNCT
ctmj-146	322	1	the	the	DET
ctmj-146	322	2	year	year	NOUN
ctmj-146	322	3	2010;75(3):310–317	2010;75(3):310–317	NUM
ctmj-146	322	4	.	.	PUNCT
ctmj-146	323	1	47.search	47.search	NUM
ctmj-146	323	2	for	for	ADP
ctmj-146	323	3	chemicals	chemical	NOUN
ctmj-146	323	4	that	that	PRON
ctmj-146	323	5	block	block	VERB
ctmj-146	323	6	zebrafish	zebrafish	X
ctmj-146	323	7	nrf	nrf	NOUN
ctmj-146	323	8	2	2	NUM
ctmj-146	323	9	etge	etge	VERB
ctmj-146	323	10	/	/	SYM
ctmj-146	323	11	dlg	dlg	NOUN
ctmj-146	323	12	motif	motif	NOUN
ctmj-146	323	13	binding	bind	VERB
ctmj-146	323	14	to	to	ADP
ctmj-146	323	15	the	the	DET
ctmj-146	323	16	keap1a	keap1a	NOUN
ctmj-146	323	17	/	/	SYM
ctmj-146	323	18	keap1b	keap1b	PROPN
ctmj-146	323	19	kelch	kelch	X
ctmj-146	323	20	dgr	dgr	PROPN
ctmj-146	323	21	domain	domain	PROPN
ctmj-146	323	22	.	.	PUNCT
ctmj-146	324	1	authors	author	NOUN
ctmj-146	324	2	:	:	PUNCT
ctmj-146	324	3	raghunath	raghunath	PROPN
ctmj-146	324	4	a	a	PRON
ctmj-146	324	5	,	,	PUNCT
ctmj-146	324	6	nagarajan	nagarajan	NOUN
ctmj-146	324	7	r	r	NOUN
ctmj-146	324	8	,	,	PUNCT
ctmj-146	324	9	sundarraj	sundarraj	VERB
ctmj-146	324	10	k	k	PROPN
ctmj-146	324	11	,	,	PUNCT
ctmj-146	324	12	palanisamy	palanisamy	PROPN
ctmj-146	324	13	k	k	PROPN
ctmj-146	324	14	,	,	PUNCT
ctmj-146	324	15	and	and	CCONJ
ctmj-146	324	16	perumal	perumal	PROPN
ctmj-146	324	17	e.	e.	PROPN
ctmj-146	324	18	foundational	foundational	PROPN
ctmj-146	324	19	clinical	clinical	ADJ
ctmj-146	324	20	pharmacology	pharmacology	NOUN
ctmj-146	324	21	and	and	CCONJ
ctmj-146	324	22	toxicology	toxicology	NOUN
ctmj-146	324	23	.	.	PUNCT
ctmj-146	325	1	125(3	125(3	NUM
ctmj-146	325	2	):	):	PUNCT
ctmj-146	325	3	259–270	259–270	NUM
ctmj-146	325	4	(	(	PUNCT
ctmj-146	325	5	2019	2019	NUM
ctmj-146	325	6	)	)	PUNCT
ctmj-146	325	7	.	.	PUNCT
ctmj-146	326	1	48.authors	48.authors	X
ctmj-146	326	2	:	:	PUNCT
ctmj-146	326	3	park	park	NOUN
ctmj-146	326	4	eh	eh	INTJ
ctmj-146	326	5	,	,	PUNCT
ctmj-146	326	6	kim	kim	PROPN
ctmj-146	326	7	s	s	PROPN
ctmj-146	326	8	,	,	PUNCT
ctmj-146	326	9	jo	jo	PROPN
ctmj-146	326	10	jy	jy	PROPN
ctmj-146	326	11	,	,	PUNCT
ctmj-146	326	12	jr	jr	PROPN
ctmj-146	326	13	.	.	PROPN
ctmj-146	326	14	pancreatic	pancreatic	ADJ
ctmj-146	326	15	cancer	cancer	NOUN
ctmj-146	326	16	cells	cell	NOUN
ctmj-146	326	17	are	be	AUX
ctmj-146	326	18	able	able	ADJ
ctmj-146	326	19	to	to	PART
ctmj-146	326	20	migrate	migrate	VERB
ctmj-146	326	21	and	and	CCONJ
ctmj-146	326	22	adhere	adhere	VERB
ctmj-146	326	23	more	more	ADV
ctmj-146	326	24	easily	easily	ADV
ctmj-146	326	25	when	when	SCONJ
ctmj-146	326	26	there	there	PRON
ctmj-146	326	27	is	be	VERB
ctmj-146	326	28	a	a	DET
ctmj-146	326	29	lack	lack	NOUN
ctmj-146	326	30	of	of	ADP
ctmj-146	326	31	collagen	collagen	NOUN
ctmj-146	326	32	triple	triple	ADJ
ctmj-146	326	33	helix	helix	ADJ
ctmj-146	326	34	repeat	repeat	NOUN
ctmj-146	326	35	containing-1	containing-1	NUM
ctmj-146	326	36	.	.	PUNCT
ctmj-146	326	37	cancer	cancer	NOUN
ctmj-146	326	38	development	development	NOUN
ctmj-146	326	39	.	.	PUNCT
ctmj-146	327	1	2013	2013	NUM
ctmj-146	327	2	,	,	PUNCT
ctmj-146	327	3	volume	volume	NOUN
ctmj-146	327	4	34	34	NUM
ctmj-146	327	5	,	,	PUNCT
ctmj-146	327	6	issue	issue	NOUN
ctmj-146	327	7	3	3	NUM
ctmj-146	327	8	,	,	PUNCT
ctmj-146	327	9	pages	page	NOUN
ctmj-146	327	10	694–2700	694–2700	NUM
ctmj-146	327	11	.	.	PUNCT
ctmj-146	328	1	49.this	49.this	DET
ctmj-146	328	2	work	work	NOUN
ctmj-146	328	3	is	be	AUX
ctmj-146	328	4	by	by	ADP
ctmj-146	328	5	ding	ding	PROPN
ctmj-146	328	6	xs	xs	PROPN
ctmj-146	328	7	,	,	PUNCT
ctmj-146	328	8	huang	huang	PROPN
ctmj-146	328	9	rh	rh	PROPN
ctmj-146	328	10	,	,	PUNCT
ctmj-146	328	11	zhong	zhong	PROPN
ctmj-146	328	12	ym	ym	PROPN
ctmj-146	328	13	,	,	PUNCT
ctmj-146	328	14	and	and	CCONJ
ctmj-146	328	15	others	other	NOUN
ctmj-146	328	16	.	.	PUNCT
ctmj-146	329	1	through	through	ADP
ctmj-146	329	2	the	the	DET
ctmj-146	329	3	hif-1a	hif-1a	PROPN
ctmj-146	329	4	/	/	SYM
ctmj-146	329	5	cxcr4	cxcr4	NOUN
ctmj-146	329	6	signaling	signal	VERB
ctmj-146	329	7	pathway	pathway	NOUN
ctmj-146	329	8	,	,	PUNCT
ctmj-146	329	9	cthrc1	cthrc1	PROPN
ctmj-146	329	10	promotes	promote	VERB
ctmj-146	329	11	the	the	DET
ctmj-146	329	12	metastasis	metastasis	NOUN
ctmj-146	329	13	of	of	ADP
ctmj-146	329	14	gastric	gastric	ADJ
ctmj-146	329	15	cancer	cancer	NOUN
ctmj-146	329	16	.	.	PUNCT
ctmj-146	330	1	medical	medical	ADJ
ctmj-146	330	2	pharmacist	pharmacist	NOUN
ctmj-146	330	3	.	.	PUNCT
ctmj-146	331	1	123	123	NUM
ctmj-146	331	2	:	:	SYM
ctmj-146	331	3	109742	109742	NUM
ctmj-146	331	4	in	in	ADP
ctmj-146	331	5	2020	2020	NUM
ctmj-146	331	6	.	.	PUNCT
ctmj-146	332	1	50.biomarkers	50.biomarker	NOUN
ctmj-146	332	2	for	for	ADP
ctmj-146	332	3	colorectal	colorectal	ADJ
ctmj-146	332	4	cancer	cancer	NOUN
ctmj-146	332	5	prediction	prediction	NOUN
ctmj-146	332	6	(	(	PUNCT
ctmj-146	332	7	ding	ding	NOUN
ctmj-146	332	8	et	et	PROPN
ctmj-146	332	9	al	al	PROPN
ctmj-146	332	10	.	.	PROPN
ctmj-146	332	11	,	,	PUNCT
ctmj-146	332	12	2018	2018	NUM
ctmj-146	332	13	)	)	PUNCT
ctmj-146	332	14	.	.	PUNCT
ctmj-146	333	1	chem	chem	NOUN
ctmj-146	333	2	.	.	PUNCT
ctmj-146	334	1	comput	comput	NOUN
ctmj-146	334	2	.	.	PUNCT
ctmj-146	335	1	the	the	DET
ctmj-146	335	2	current	current	ADJ
ctmj-146	335	3	time	time	NOUN
ctmj-146	335	4	is	be	AUX
ctmj-146	335	5	2019	2019	NUM
ctmj-146	335	6	-	-	SYM
ctmj-146	335	7	03	03	NUM
ctmj-146	335	8	-	-	SYM
ctmj-146	335	9	23	23	NUM
ctmj-146	335	10	at	at	ADP
ctmj-146	335	11	07:30:106	07:30:106	NOUN
ctmj-146	335	12	.	.	PUNCT
ctmj-146	336	1	51.y	51.y	NUM
ctmj-146	336	2	.	.	PUNCT
ctmj-146	337	1	liu	liu	PROPN
ctmj-146	337	2	,	,	PUNCT
ctmj-146	337	3	n.	n.	PROPN
ctmj-146	337	4	abulimiti	abulimiti	PROPN
ctmj-146	337	5	,	,	PUNCT
ctmj-146	337	6	and	and	CCONJ
ctmj-146	337	7	c.	c.	PROPN
ctmj-146	337	8	wang	wang	PROPN
ctmj-146	337	9	.	.	PUNCT
ctmj-146	338	1	expression	expression	NOUN
ctmj-146	338	2	of	of	ADP
ctmj-146	338	3	collagen	collagen	NOUN
ctmj-146	338	4	triple	triple	ADJ
ctmj-146	338	5	helix	helix	ADJ
ctmj-146	338	6	repeat	repeat	NOUN
ctmj-146	338	7	containing	contain	VERB
ctmj-146	338	8	1	1	NUM
ctmj-146	338	9	in	in	ADP
ctmj-146	338	10	osteosarcoma	osteosarcoma	NOUN
ctmj-146	338	11	:	:	PUNCT
ctmj-146	338	12	a	a	DET
ctmj-146	338	13	novel	novel	ADJ
ctmj-146	338	14	prognostic	prognostic	ADJ
ctmj-146	338	15	indicator	indicator	NOUN
ctmj-146	338	16	.	.	PUNCT
ctmj-146	339	1	clinical	clinical	ADJ
ctmj-146	339	2	laboratory	laboratory	NOUN
ctmj-146	339	3	science	science	NOUN
ctmj-146	339	4	abstracts	abstract	NOUN
ctmj-146	339	5	.	.	PUNCT
ctmj-146	340	1	the	the	DET
ctmj-146	340	2	current	current	ADJ
ctmj-146	340	3	version	version	NOUN
ctmj-146	340	4	is	be	AUX
ctmj-146	340	5	:	:	PUNCT
ctmj-146	340	6	2018;48(3	2018;48(3	NUM
ctmj-146	340	7	):	):	PUNCT
ctmj-146	340	8	338–344	338–344	NUM
ctmj-146	340	9	.	.	PUNCT
ctmj-146	341	1	52.this	52.this	DET
ctmj-146	341	2	work	work	NOUN
ctmj-146	341	3	is	be	AUX
ctmj-146	341	4	by	by	ADP
ctmj-146	341	5	zhou	zhou	PROPN
ctmj-146	341	6	hf	hf	PROPN
ctmj-146	341	7	,	,	PUNCT
ctmj-146	341	8	liu	liu	PROPN
ctmj-146	341	9	c	c	PROPN
ctmj-146	341	10	,	,	PUNCT
ctmj-146	341	11	su	su	PROPN
ctmj-146	341	12	lb	lb	PROPN
ctmj-146	341	13	,	,	PUNCT
ctmj-146	341	14	and	and	CCONJ
ctmj-146	341	15	others	other	NOUN
ctmj-146	341	16	.	.	PUNCT
ctmj-146	342	1	hepatocellular	hepatocellular	ADJ
ctmj-146	342	2	carcinoma	carcinoma	NOUN
ctmj-146	342	3	prognostic	prognostic	ADJ
ctmj-146	342	4	biomarkers	biomarker	NOUN
ctmj-146	342	5	may	may	AUX
ctmj-146	342	6	include	include	VERB
ctmj-146	342	7	cthrc1	cthrc1	PROPN
ctmj-146	342	8	.	.	PUNCT
ctmj-146	343	1	ther	ther	PROPN
ctmj-146	343	2	oncotargets	oncotarget	NOUN
ctmj-146	343	3	.	.	PUNCT
ctmj-146	344	1	12:7823–7831	12:7823–7831	NUM
ctmj-146	344	2	(	(	PUNCT
ctmj-146	344	3	2019	2019	NUM
ctmj-146	344	4	)	)	PUNCT
ctmj-146	344	5	.	.	PUNCT
ctmj-146	345	1	53.authors	53.author	NOUN
ctmj-146	345	2	:	:	PUNCT
ctmj-146	345	3	lv	lv	PROPN
ctmj-146	345	4	yf	yf	PROPN
ctmj-146	345	5	,	,	PUNCT
ctmj-146	345	6	zhang	zhang	PROPN
ctmj-146	345	7	lq	lq	PROPN
ctmj-146	345	8	,	,	PUNCT
ctmj-146	345	9	ma	ma	PROPN
ctmj-146	345	10	jy	jy	PROPN
ctmj-146	345	11	,	,	PUNCT
ctmj-146	345	12	fei	fei	PROPN
ctmj-146	345	13	xw	xw	PROPN
ctmj-146	345	14	,	,	PUNCT
ctmj-146	345	15	xu	xu	PROPN
ctmj-146	346	1	kh	kh	PROPN
ctmj-146	346	2	,	,	PUNCT
ctmj-146	346	3	lin	lin	PROPN
ctmj-146	346	4	j.	j.	PROPN
ctmj-146	346	5	cthrc1	cthrc1	PROPN
ctmj-146	346	6	overexpression	overexpression	NOUN
ctmj-146	346	7	activates	activate	VERB
ctmj-146	346	8	the	the	DET
ctmj-146	346	9	wnt	wnt	PROPN
ctmj-146	346	10	/	/	SYM
ctmj-146	346	11	b	b	NOUN
ctmj-146	346	12	-	-	PUNCT
ctmj-146	346	13	catenin	catenin	NOUN
ctmj-146	346	14	pathway	pathway	NOUN
ctmj-146	346	15	,	,	PUNCT
ctmj-146	346	16	which	which	PRON
ctmj-146	346	17	increases	increase	VERB
ctmj-146	346	18	migration	migration	NOUN
ctmj-146	346	19	,	,	PUNCT
ctmj-146	346	20	invasion	invasion	NOUN
ctmj-146	346	21	,	,	PUNCT
ctmj-146	346	22	and	and	CCONJ
ctmj-146	346	23	proliferation	proliferation	NOUN
ctmj-146	346	24	of	of	ADP
ctmj-146	346	25	stromal	stromal	ADJ
ctmj-146	346	26	cells	cell	NOUN
ctmj-146	346	27	in	in	ADP
ctmj-146	346	28	the	the	DET
ctmj-146	346	29	ectopic	ectopic	NOUN
ctmj-146	346	30	endometrium	endometrium	NOUN
ctmj-146	346	31	.	.	PUNCT
ctmj-146	347	1	online	online	ADV
ctmj-146	347	2	at	at	SCONJ
ctmj-146	347	3	reprod	reprod	PROPN
ctmj-146	347	4	biomed	biome	VERB
ctmj-146	347	5	.	.	PUNCT
ctmj-146	348	1	pp	pp	ADV
ctmj-146	348	2	.	.	PUNCT
ctmj-146	349	1	26–32	26–32	NUM
ctmj-146	349	2	in	in	ADP
ctmj-146	349	3	2020;40(1	2020;40(1	NUM
ctmj-146	349	4	)	)	PUNCT
ctmj-146	349	5	.	.	PUNCT
ctmj-146	350	1	54.a	54.a	NUM
ctmj-146	350	2	particular	particular	ADJ
ctmj-146	350	3	monoclonal	monoclonal	NOUN
ctmj-146	350	4	antibody	antibody	NOUN
ctmj-146	350	5	inhibits	inhibit	VERB
ctmj-146	350	6	cthrc-1	cthrc-1	NUM
ctmj-146	350	7	,	,	PUNCT
ctmj-146	350	8	which	which	PRON
ctmj-146	350	9	in	in	ADP
ctmj-146	350	10	turn	turn	NOUN
ctmj-146	350	11	reduces	reduce	VERB
ctmj-146	350	12	cervical	cervical	ADJ
ctmj-146	350	13	cancer	cancer	NOUN
ctmj-146	350	14	cell	cell	NOUN
ctmj-146	350	15	metastasis	metastasis	NOUN
ctmj-146	350	16	(	(	PUNCT
ctmj-146	350	17	cui	cui	NOUN
ctmj-146	350	18	xx	xx	NUM
ctmj-146	350	19	,	,	PUNCT
ctmj-146	350	20	ding	de	VERB
ctmj-146	350	21	hm	hm	INTJ
ctmj-146	350	22	,	,	PUNCT
ctmj-146	350	23	gu	gu	NOUN
ctmj-146	350	24	f	f	PROPN
ctmj-146	350	25	,	,	PUNCT
ctmj-146	350	26	lv	lv	PROPN
ctmj-146	350	27	yy	yy	PROPN
ctmj-146	350	28	,	,	PUNCT
ctmj-146	350	29	xing	xing	PROPN
ctmj-146	350	30	x	x	PROPN
ctmj-146	350	31	,	,	PUNCT
ctmj-146	350	32	zhang	zhang	PROPN
ctmj-146	350	33	r.	r.	PROPN
ctmj-146	350	34	)	)	PUNCT
ctmj-146	350	35	.	.	PUNCT
ctmj-146	351	1	medical	medical	ADJ
ctmj-146	351	2	pharmacist	pharmacist	NOUN
ctmj-146	351	3	.	.	PUNCT
ctmj-146	352	1	the	the	DET
ctmj-146	352	2	current	current	ADJ
ctmj-146	352	3	version	version	NOUN
ctmj-146	352	4	is	be	AUX
ctmj-146	352	5	2019	2019	NUM
ctmj-146	352	6	at	at	ADP
ctmj-146	352	7	110:758	110:758	NUM
ctmj-146	352	8	–	–	PUNCT
ctmj-146	352	9	s763	s763	PROPN
ctmj-146	352	10	.	.	PUNCT
ctmj-146	353	1	55.ovarian	55.ovarian	NUM
ctmj-146	353	2	cancer	cancer	NOUN
ctmj-146	353	3	metastasis	metastasis	NOUN
ctmj-146	353	4	is	be	AUX
ctmj-146	353	5	facilitated	facilitate	VERB
ctmj-146	353	6	by	by	ADP
ctmj-146	353	7	collagen	collagen	NOUN
ctmj-146	353	8	triple	triple	ADJ
ctmj-146	353	9	helix	helix	ADJ
ctmj-146	353	10	repeat	repeat	NOUN
ctmj-146	353	11	containing	contain	VERB
ctmj-146	353	12	1	1	NUM
ctmj-146	353	13	(	(	PUNCT
ctmj-146	353	14	cthrc1	cthrc1	NOUN
ctmj-146	353	15	)	)	PUNCT
ctmj-146	353	16	,	,	PUNCT
ctmj-146	353	17	according	accord	VERB
ctmj-146	353	18	to	to	ADP
ctmj-146	353	19	research	research	NOUN
ctmj-146	353	20	by	by	ADP
ctmj-146	353	21	guo	guo	PROPN
ctmj-146	353	22	by	by	ADP
ctmj-146	353	23	,	,	PUNCT
ctmj-146	353	24	yan	yan	PROPN
ctmj-146	353	25	h	h	PROPN
ctmj-146	353	26	,	,	PUNCT
ctmj-146	353	27	li	li	PROPN
ctmj-146	353	28	ly	ly	PROPN
ctmj-146	353	29	,	,	PUNCT
ctmj-146	353	30	yin	yin	PROPN
ctmj-146	353	31	km	km	PROPN
ctmj-146	353	32	,	,	PUNCT
ctmj-146	353	33	ji	ji	PROPN
ctmj-146	353	34	f	f	X
ctmj-146	353	35	,	,	PUNCT
ctmj-146	353	36	and	and	CCONJ
ctmj-146	353	37	zhang	zhang	PROPN
ctmj-146	353	38	s.	s.	PROPN
ctmj-146	353	39	the	the	DET
ctmj-146	353	40	article	article	NOUN
ctmj-146	353	41	is	be	AUX
ctmj-146	353	42	published	publish	VERB
ctmj-146	353	43	in	in	ADP
ctmj-146	353	44	the	the	DET
ctmj-146	353	45	journal	journal	NOUN
ctmj-146	353	46	of	of	ADP
ctmj-146	353	47	ovarian	ovarian	ADJ
ctmj-146	353	48	research	research	NOUN
ctmj-146	353	49	and	and	CCONJ
ctmj-146	353	50	has	have	VERB
ctmj-146	353	51	the	the	DET
ctmj-146	353	52	doi	doi	NOUN
ctmj-146	353	53	:	:	PUNCT
ctmj-146	353	54	10(1):69	10(1):69	NUM
ctmj-146	353	55	.	.	PUNCT
ctmj-146	354	1	56.saponins	56.saponins	NUM
ctmj-146	354	2	,	,	PUNCT
ctmj-146	354	3	their	their	PRON
ctmj-146	354	4	distribution	distribution	NOUN
ctmj-146	354	5	and	and	CCONJ
ctmj-146	354	6	categorization	categorization	NOUN
ctmj-146	354	7	in	in	ADP
ctmj-146	354	8	plants	plant	NOUN
ctmj-146	354	9	,	,	PUNCT
ctmj-146	354	10	by	by	ADP
ctmj-146	354	11	vincken	vincken	PROPN
ctmj-146	354	12	jp	jp	PROPN
ctmj-146	354	13	,	,	PUNCT
ctmj-146	354	14	heng	heng	PROPN
ctmj-146	354	15	l	l	PROPN
ctmj-146	354	16	,	,	PUNCT
ctmj-146	354	17	de	de	X
ctmj-146	354	18	groot	groot	X
ctmj-146	354	19	a	a	NOUN
ctmj-146	354	20	,	,	PUNCT
ctmj-146	354	21	and	and	CCONJ
ctmj-146	354	22	gruppen	gruppen	PROPN
ctmj-146	354	23	h.	h.	PROPN
ctmj-146	354	24	science	science	NOUN
ctmj-146	354	25	of	of	ADP
ctmj-146	354	26	plants	plant	NOUN
ctmj-146	354	27	.	.	PUNCT
ctmj-146	355	1	published	publish	VERB
ctmj-146	355	2	in	in	ADP
ctmj-146	355	3	2007	2007	NUM
ctmj-146	355	4	with	with	ADP
ctmj-146	355	5	an	an	DET
ctmj-146	355	6	isbn	isbn	ADJ
ctmj-146	355	7	68(3	68(3	PROPN
ctmj-146	355	8	):	):	PUNCT
ctmj-146	355	9	275–297	275–297	NUM
ctmj-146	355	10	.	.	PUNCT
ctmj-146	356	1	57.according	57.accorde	VERB
ctmj-146	356	2	to	to	ADP
ctmj-146	356	3	tavarez	tavarez	PROPN
ctmj-146	356	4	-	-	PUNCT
ctmj-146	356	5	santamaría	santamaría	PROPN
ctmj-146	356	6	z	z	PROPN
ctmj-146	356	7	,	,	PUNCT
ctmj-146	356	8	jacoboherrera	jacoboherrera	PROPN
ctmj-146	356	9	nj	nj	PROPN
ctmj-146	356	10	,	,	PUNCT
ctmj-146	356	11	rocha	rocha	PROPN
ctmj-146	356	12	-	-	PROPN
ctmj-146	356	13	zavaleta	zavaleta	PROPN
ctmj-146	356	14	l	l	NOUN
ctmj-146	356	15	,	,	PUNCT
ctmj-146	356	16	zentella	zentella	NOUN
ctmj-146	356	17	-	-	PUNCT
ctmj-146	356	18	dehesa	dehesa	PROPN
ctmj-146	356	19	a	a	DET
ctmj-146	356	20	,	,	PUNCT
ctmj-146	356	21	couder	couder	NOUN
ctmj-146	356	22	-	-	PUNCT
ctmj-146	356	23	garcía	garcía	ADJ
ctmj-146	356	24	bdc	bdc	NOUN
ctmj-146	356	25	,	,	PUNCT
ctmj-146	356	26	and	and	CCONJ
ctmj-146	356	27	martínez	martínez	PROPN
ctmj-146	356	28	-	-	PUNCT
ctmj-146	356	29	v'azquez	v'azquez	PROPN
ctmj-146	356	30	m.	m.	NOUN
ctmj-146	356	31	,	,	PUNCT
ctmj-146	356	32	the	the	DET
ctmj-146	356	33	anti	anti	ADJ
ctmj-146	356	34	-	-	ADJ
ctmj-146	356	35	tumor	tumor	ADJ
ctmj-146	356	36	efficacy	efficacy	NOUN
ctmj-146	356	37	of	of	ADP
ctmj-146	356	38	the	the	DET
ctmj-146	356	39	nontoxic	nontoxic	ADJ
ctmj-146	356	40	cycloartanetype	cycloartanetype	NOUN
ctmj-146	356	41	triterpene	triterpene	PROPN
ctmj-146	356	42	argentatin	argentatin	PROPN
ctmj-146	356	43	was	be	AUX
ctmj-146	356	44	enhanced	enhance	VERB
ctmj-146	356	45	with	with	ADP
ctmj-146	356	46	a	a	DET
ctmj-146	356	47	greater	great	ADJ
ctmj-146	356	48	frequency	frequency	NOUN
ctmj-146	356	49	of	of	ADP
ctmj-146	356	50	administration	administration	NOUN
ctmj-146	356	51	.	.	PUNCT
ctmj-146	357	1	small	small	ADJ
ctmj-146	357	2	biological	biological	ADJ
ctmj-146	357	3	units	unit	NOUN
ctmj-146	357	4	.	.	PUNCT
ctmj-146	358	1	2020	2020	NUM
ctmj-146	359	1	[	[	X
ctmj-146	359	2	july	july	PROPN
ctmj-146	359	3	25];25(8	25];25(8	NUM
ctmj-146	359	4	):	):	PUNCT
ctmj-146	359	5	1780	1780	NUM
ctmj-146	359	6	.	.	PUNCT
ctmj-146	360	1	58.it	58.it	NUM
ctmj-146	360	2	was	be	AUX
ctmj-146	360	3	written	write	VERB
ctmj-146	360	4	by	by	ADP
ctmj-146	360	5	wu	wu	PROPN
ctmj-146	360	6	xx	xx	PROPN
ctmj-146	360	7	,	,	PUNCT
ctmj-146	360	8	yue	yue	PROPN
ctmj-146	360	9	gg	gg	PROPN
ctmj-146	360	10	,	,	PUNCT
ctmj-146	360	11	dong	dong	PROPN
ctmj-146	360	12	jr	jr	PROPN
ctmj-146	360	13	,	,	PUNCT
ctmj-146	360	14	and	and	CCONJ
ctmj-146	360	15	others	other	NOUN
ctmj-146	360	16	.	.	PUNCT
ctmj-146	361	1	actein	actein	PROPN
ctmj-146	361	2	suppresses	suppress	VERB
ctmj-146	361	3	the	the	DET
ctmj-146	361	4	akt	akt	PROPN
ctmj-146	361	5	/	/	SYM
ctmj-146	361	6	mtor	mtor	PROPN
ctmj-146	361	7	and	and	CCONJ
ctmj-146	361	8	ras	ras	PROPN
ctmj-146	361	9	/	/	SYM
ctmj-146	361	10	raf	raf	PROPN
ctmj-146	361	11	/	/	SYM
ctmj-146	361	12	mapk	mapk	NOUN
ctmj-146	361	13	signaling	signal	VERB
ctmj-146	361	14	pathways	pathway	NOUN
ctmj-146	361	15	,	,	PUNCT
ctmj-146	361	16	which	which	PRON
ctmj-146	361	17	in	in	ADP
ctmj-146	361	18	turn	turn	NOUN
ctmj-146	361	19	decrease	decrease	VERB
ctmj-146	361	20	tumor	tumor	NOUN
ctmj-146	361	21	development	development	NOUN
ctmj-146	361	22	and	and	CCONJ
ctmj-146	361	23	metastasis	metastasis	NOUN
ctmj-146	361	24	in	in	ADP
ctmj-146	361	25	mice	mouse	NOUN
ctmj-146	361	26	with	with	ADP
ctmj-146	361	27	her2	her2	PROPN
ctmj-146	361	28	-	-	PUNCT
ctmj-146	361	29	positive	positive	ADJ
ctmj-146	361	30	breast	breast	NOUN
ctmj-146	361	31	tumors	tumor	NOUN
ctmj-146	361	32	.	.	PUNCT
ctmj-146	362	1	journal	journal	NOUN
ctmj-146	362	2	of	of	ADP
ctmj-146	362	3	oncology	oncology	NOUN
ctmj-146	362	4	.	.	PUNCT
ctmj-146	363	1	in	in	ADP
ctmj-146	363	2	2020;10:854	2020;10:854	NUM
ctmj-146	363	3	.	.	PUNCT
ctmj-146	364	1	59.by	59.by	NUM
ctmj-146	364	2	kaneda	kaneda	PROPN
ctmj-146	364	3	t	t	PROPN
ctmj-146	364	4	,	,	PUNCT
ctmj-146	364	5	matsumoto	matsumoto	PROPN
ctmj-146	364	6	m	m	PROPN
ctmj-146	364	7	,	,	PUNCT
ctmj-146	364	8	sotozono	sotozono	VERB
ctmj-146	364	9	y	y	PROPN
ctmj-146	364	10	,	,	PUNCT
ctmj-146	364	11	and	and	CCONJ
ctmj-146	364	12	colleagues	colleague	NOUN
ctmj-146	364	13	.	.	PUNCT
ctmj-146	365	1	by	by	ADP
ctmj-146	365	2	inhibiting	inhibit	VERB
ctmj-146	365	3	the	the	DET
ctmj-146	365	4	b	b	NOUN
ctmj-146	365	5	-	-	PUNCT
ctmj-146	365	6	catenin	catenin	NOUN
ctmj-146	365	7	and	and	CCONJ
ctmj-146	365	8	c	c	NOUN
ctmj-146	365	9	-	-	PUNCT
ctmj-146	365	10	rafmek1	rafmek1	NOUN
ctmj-146	365	11	-	-	PUNCT
ctmj-146	365	12	erk	erk	NOUN
ctmj-146	365	13	signaling	signal	VERB
ctmj-146	365	14	pathway	pathway	NOUN
ctmj-146	365	15	,	,	PUNCT
ctmj-146	365	16	the	the	DET
ctmj-146	365	17	cycloartane	cycloartane	NOUN
ctmj-146	365	18	triterpenoid	triterpenoid	NOUN
ctmj-146	365	19	(	(	PUNCT
ctmj-146	365	20	23r	23r	NOUN
ctmj-146	365	21	,	,	PUNCT
ctmj-146	365	22	24e)-23	24e)-23	NOUN
ctmj-146	365	23	-	-	PUNCT
ctmj-146	365	24	acetoxymangiferonic	acetoxymangiferonic	ADJ
ctmj-146	365	25	acid	acid	NOUN
ctmj-146	365	26	reduced	reduce	VERB
ctmj-146	365	27	mitf	mitf	ADJ
ctmj-146	365	28	downregulation	downregulation	NOUN
ctmj-146	365	29	and	and	CCONJ
ctmj-146	365	30	melanoma	melanoma	NOUN
ctmj-146	365	31	cell	cell	NOUN
ctmj-146	365	32	proliferation	proliferation	NOUN
ctmj-146	365	33	and	and	CCONJ
ctmj-146	365	34	migration	migration	NOUN
ctmj-146	365	35	in	in	ADP
ctmj-146	365	36	b16	b16	NOUN
ctmj-146	365	37	-	-	PUNCT
ctmj-146	365	38	f10	f10	NOUN
ctmj-146	365	39	tumors	tumor	NOUN
ctmj-146	365	40	.	.	PUNCT
ctmj-146	366	1	j	j	PROPN
ctmj-146	366	2	nat	nat	PROPN
ctmj-146	366	3	med	me	VERB
ctmj-146	366	4	.	.	PUNCT
ctmj-146	367	1	2019;73(1):47–58	2019;73(1):47–58	NUM
ctmj-146	367	2	.	.	PUNCT
ctmj-146	368	1	60.in	60.in	NUM
ctmj-146	368	2	vitro	vitro	X
ctmj-146	368	3	evidence	evidence	NOUN
ctmj-146	368	4	of	of	ADP
ctmj-146	368	5	cycloartane-3,24,25	cycloartane-3,24,25	NOUN
ctmj-146	368	6	-	-	PUNCT
ctmj-146	368	7	triol	triol	NOUN
ctmj-146	368	8	's	's	PART
ctmj-146	368	9	anti	anti	ADJ
ctmj-146	368	10	-	-	ADJ
ctmj-146	368	11	prostate	prostate	ADJ
ctmj-146	368	12	cancer	cancer	NOUN
ctmj-146	368	13	activity	activity	NOUN
ctmj-146	368	14	and	and	CCONJ
ctmj-146	368	15	its	its	PRON
ctmj-146	368	16	ability	ability	NOUN
ctmj-146	368	17	to	to	PART
ctmj-146	368	18	inhibit	inhibit	VERB
ctmj-146	368	19	mrcka	mrcka	PROPN
ctmj-146	368	20	kinase	kinase	PROPN
ctmj-146	368	21	has	have	AUX
ctmj-146	368	22	been	be	AUX
ctmj-146	368	23	shown	show	VERB
ctmj-146	368	24	by	by	ADP
ctmj-146	368	25	lowe	lowe	PROPN
ctmj-146	368	26	hi	hi	PROPN
ctmj-146	368	27	,	,	PUNCT
ctmj-146	368	28	watson	watson	PROPN
ctmj-146	368	29	ct	ct	PROPN
ctmj-146	368	30	,	,	PUNCT
ctmj-146	368	31	badal	badal	PROPN
ctmj-146	368	32	s	s	PROPN
ctmj-146	368	33	,	,	PUNCT
ctmj-146	368	34	toyang	toyang	PROPN
ctmj-146	368	35	nj	nj	PROPN
ctmj-146	368	36	,	,	PUNCT
ctmj-146	368	37	and	and	CCONJ
ctmj-146	368	38	bryant	bryant	PROPN
ctmj-146	368	39	j.	j.	PROPN
ctmj-146	368	40	cancer	cancer	PROPN
ctmj-146	368	41	cell	cell	PROPN
ctmj-146	368	42	international	international	PROPN
ctmj-146	368	43	.	.	PUNCT
ctmj-146	369	1	12(1	12(1	NUM
ctmj-146	369	2	):	):	PUNCT
ctmj-146	369	3	46	46	NUM
ctmj-146	369	4	in	in	ADP
ctmj-146	369	5	2012	2012	NUM
ctmj-146	369	6	.	.	PUNCT
ctmj-146	370	1	61.the	61.the	PRON
ctmj-146	370	2	actin	actin	NOUN
ctmj-146	370	3	-	-	PUNCT
ctmj-146	370	4	myosin	myosin	NOUN
ctmj-146	370	5	regulatory	regulatory	ADJ
ctmj-146	370	6	mrck	mrck	NOUN
ctmj-146	370	7	kinases	kinase	NOUN
ctmj-146	370	8	:	:	PUNCT
ctmj-146	370	9	regulation	regulation	NOUN
ctmj-146	370	10	,	,	PUNCT
ctmj-146	370	11	biological	biological	ADJ
ctmj-146	370	12	roles	role	NOUN
ctmj-146	370	13	,	,	PUNCT
ctmj-146	370	14	and	and	CCONJ
ctmj-146	370	15	links	link	NOUN
ctmj-146	370	16	to	to	ADP
ctmj-146	370	17	human	human	ADJ
ctmj-146	370	18	cancer	cancer	NOUN
ctmj-146	370	19	(	(	PUNCT
ctmj-146	370	20	unbekandt	unbekandt	NOUN
ctmj-146	370	21	m	m	PROPN
ctmj-146	370	22	,	,	PUNCT
ctmj-146	370	23	olson	olson	PROPN
ctmj-146	370	24	mf	mf	PROPN
ctmj-146	370	25	,	,	PUNCT
ctmj-146	370	26	2004	2004	NUM
ctmj-146	370	27	)	)	PUNCT
ctmj-146	370	28	.	.	PUNCT
ctmj-146	371	1	berlin	berlin	PROPN
ctmj-146	371	2	:	:	PUNCT
ctmj-146	371	3	journal	journal	NOUN
ctmj-146	371	4	of	of	ADP
ctmj-146	371	5	molecular	molecular	ADJ
ctmj-146	371	6	medicine	medicine	NOUN
ctmj-146	371	7	.	.	PUNCT
ctmj-146	372	1	published	publish	VERB
ctmj-146	372	2	in	in	ADP
ctmj-146	372	3	2014	2014	NUM
ctmj-146	372	4	,	,	PUNCT
ctmj-146	372	5	volume	volume	NOUN
ctmj-146	372	6	92	92	NUM
ctmj-146	372	7	,	,	PUNCT
ctmj-146	372	8	issue	issue	NOUN
ctmj-146	372	9	3	3	NUM
ctmj-146	372	10	,	,	PUNCT
ctmj-146	372	11	pages	page	NOUN
ctmj-146	372	12	217–225	217–225	NUM
ctmj-146	372	13	.	.	PUNCT
ctmj-146	373	1	62.members	62.member	NOUN
ctmj-146	373	2	of	of	ADP
ctmj-146	373	3	the	the	DET
ctmj-146	373	4	research	research	NOUN
ctmj-146	373	5	team	team	NOUN
ctmj-146	373	6	:	:	PUNCT
ctmj-146	373	7	celano	celano	VERB
ctmj-146	373	8	sl	sl	PROPN
ctmj-146	373	9	,	,	PUNCT
ctmj-146	373	10	yco	yco	NOUN
ctmj-146	373	11	lp	lp	NOUN
ctmj-146	373	12	,	,	PUNCT
ctmj-146	373	13	kortus	kortus	ADJ
ctmj-146	373	14	mg	mg	PROPN
ctmj-146	373	15	,	,	PUNCT
ctmj-146	373	16	jr	jr	PROPN
ctmj-146	373	17	.	.	PUNCT
ctmj-146	373	18	finding	find	VERB
ctmj-146	373	19	the	the	DET
ctmj-146	373	20	kinases	kinase	NOUN
ctmj-146	373	21	that	that	PRON
ctmj-146	373	22	trigger	trigger	NOUN
ctmj-146	373	23	autophagy	autophagy	VERB
ctmj-146	373	24	in	in	ADP
ctmj-146	373	25	response	response	NOUN
ctmj-146	373	26	to	to	ADP
ctmj-146	373	27	p53	p53	NOUN
ctmj-146	373	28	degradation	degradation	NOUN
ctmj-146	373	29	.	.	PUNCT
ctmj-146	374	1	academic	academic	ADJ
ctmj-146	374	2	research	research	NOUN
ctmj-146	374	3	.	.	PUNCT
ctmj-146	375	1	the	the	DET
ctmj-146	375	2	current	current	ADJ
ctmj-146	375	3	version	version	NOUN
ctmj-146	375	4	is	be	AUX
ctmj-146	375	5	(	(	PUNCT
ctmj-146	375	6	15	15	NUM
ctmj-146	375	7	march	march	NOUN
ctmj-146	375	8	2019	2019	NUM
ctmj-146	375	9	):	):	PUNCT
ctmj-146	375	10	109–118	109–118	NUM
ctmj-146	375	11	.	.	PUNCT
ctmj-146	376	1	63.along	63.along	NUM
ctmj-146	376	2	with	with	ADP
ctmj-146	376	3	unbekandt	unbekandt	ADJ
ctmj-146	376	4	,	,	PUNCT
ctmj-146	376	5	belshaw	belshaw	NOUN
ctmj-146	376	6	,	,	PUNCT
ctmj-146	376	7	and	and	CCONJ
ctmj-146	376	8	bower	bower	NOUN
ctmj-146	376	9	,	,	PUNCT
ctmj-146	376	10	et	et	PROPN
ctmj-146	376	11	al	al	PROPN
ctmj-146	376	12	.	.	PUNCT
ctmj-146	377	1	the	the	DET
ctmj-146	377	2	development	development	NOUN
ctmj-146	377	3	of	of	ADP
ctmj-146	377	4	therapeutically	therapeutically	ADV
ctmj-146	377	5	effective	effective	ADJ
ctmj-146	377	6	mrck	mrck	NOUN
ctmj-146	377	7	inhibitors	inhibitor	NOUN
ctmj-146	377	8	for	for	ADP
ctmj-146	377	9	the	the	DET
ctmj-146	377	10	treatment	treatment	NOUN
ctmj-146	377	11	of	of	ADP
ctmj-146	377	12	skin	skin	NOUN
ctmj-146	377	13	cancer	cancer	NOUN
ctmj-146	377	14	.	.	PUNCT
ctmj-146	378	1	the	the	DET
ctmj-146	378	2	published	publish	VERB
ctmj-146	378	3	article	article	NOUN
ctmj-146	378	4	is	be	AUX
ctmj-146	378	5	canc	canc	PROPN
ctmj-146	378	6	res	re	NOUN
ctmj-146	378	7	78(8	78(8	NUM
ctmj-146	378	8	):	):	PUNCT
ctmj-146	378	9	2096	2096	NUM
ctmj-146	378	10	–	–	PUNCT
ctmj-146	378	11	2141	2141	NUM
ctmj-146	378	12	.	.	PUNCT
ctmj-146	379	1	64.possible	64.possible	NUM
ctmj-146	380	1	actein	actein	ADV
ctmj-146	380	2	targets	target	NOUN
ctmj-146	380	3	discovered	discover	VERB
ctmj-146	380	4	using	use	VERB
ctmj-146	380	5	systems	system	NOUN
ctmj-146	380	6	chemical	chemical	NOUN
ctmj-146	380	7	biology	biology	NOUN
ctmj-146	380	8	techniques	technique	NOUN
ctmj-146	380	9	(	(	PUNCT
ctmj-146	380	10	liao	liao	PROPN
ctmj-146	380	11	x	x	PROPN
ctmj-146	380	12	,	,	PUNCT
ctmj-146	380	13	zhang	zhang	PROPN
ctmj-146	380	14	qy	qy	PROPN
ctmj-146	380	15	,	,	PUNCT
ctmj-146	380	16	xu	xu	PROPN
ctmj-146	381	1	l	l	PROPN
ctmj-146	381	2	,	,	PUNCT
ctmj-146	381	3	zhang	zhang	PROPN
ctmj-146	381	4	hy	hy	PROPN
ctmj-146	381	5	)	)	PUNCT
ctmj-146	381	6	.	.	PUNCT
ctmj-146	382	1	the	the	DET
ctmj-146	382	2	chemical	chemical	PROPN
ctmj-146	382	3	database	database	PROPN
ctmj-146	382	4	chemmedchem	chemmedchem	PROPN
ctmj-146	382	5	.	.	PUNCT
ctmj-146	383	1	480–473	480–473	NUM
ctmj-146	383	2	(	(	PUNCT
ctmj-146	383	3	2020	2020	NUM
ctmj-146	383	4	)	)	PUNCT
ctmj-146	383	5	.	.	PUNCT
ctmj-146	384	1	65.the	65.the	DET
ctmj-146	384	2	authors	author	NOUN
ctmj-146	384	3	of	of	ADP
ctmj-146	384	4	the	the	DET
ctmj-146	384	5	study	study	NOUN
ctmj-146	384	6	include	include	VERB
ctmj-146	384	7	li	li	PROPN
ctmj-146	384	8	yn	yn	PROPN
ctmj-146	384	9	,	,	PUNCT
ctmj-146	384	10	wang	wang	PROPN
ctmj-146	384	11	j	j	PROPN
ctmj-146	384	12	,	,	PUNCT
ctmj-146	384	13	song	song	PROPN
ctmj-146	384	14	k	k	PROPN
ctmj-146	384	15	,	,	PUNCT
ctmj-146	384	16	and	and	CCONJ
ctmj-146	384	17	others	other	NOUN
ctmj-146	384	18	.	.	PUNCT
ctmj-146	385	1	by	by	ADP
ctmj-146	385	2	increasing	increase	VERB
ctmj-146	385	3	the	the	DET
ctmj-146	385	4	stemness	stemness	NOUN
ctmj-146	385	5	of	of	ADP
ctmj-146	385	6	cancer	cancer	NOUN
ctmj-146	385	7	cells	cell	NOUN
ctmj-146	385	8	linked	link	VERB
ctmj-146	385	9	to	to	ADP
ctmj-146	385	10	fibrosis	fibrosis	NOUN
ctmj-146	385	11	,	,	PUNCT
ctmj-146	385	12	s100a4	s100a4	ADV
ctmj-146	385	13	promotes	promote	VERB
ctmj-146	385	14	hepatocellular	hepatocellular	ADJ
ctmj-146	385	15	carcinogenesis	carcinogenesis	NOUN
ctmj-146	385	16	.	.	PUNCT
ctmj-146	386	1	immunology	immunology	NOUN
ctmj-146	386	2	in	in	ADP
ctmj-146	386	3	cancer	cancer	NOUN
ctmj-146	386	4	.	.	PUNCT
ctmj-146	387	1	publication	publication	NOUN
ctmj-146	387	2	year	year	NOUN
ctmj-146	387	3	2020;9(1):1725355	2020;9(1):1725355	NUM
ctmj-146	387	4	.	.	PUNCT
ctmj-146	388	1	66.by	66.by	PROPN
ctmj-146	389	1	zhu	zhu	PROPN
ctmj-146	389	2	k	k	PROPN
ctmj-146	389	3	,	,	PUNCT
ctmj-146	389	4	huang	huang	PROPN
ctmj-146	389	5	ww	ww	PROPN
ctmj-146	389	6	,	,	PUNCT
ctmj-146	389	7	wang	wang	PROPN
ctmj-146	389	8	wj	wj	PROPN
ctmj-146	389	9	,	,	PUNCT
ctmj-146	389	10	and	and	CCONJ
ctmj-146	389	11	colleagues	colleague	NOUN
ctmj-146	389	12	.	.	PUNCT
ctmj-146	390	1	hepatocellular	hepatocellular	ADJ
ctmj-146	390	2	carcinoma	carcinoma	NOUN
ctmj-146	390	3	cell	cell	NOUN
ctmj-146	390	4	proliferation	proliferation	NOUN
ctmj-146	390	5	and	and	CCONJ
ctmj-146	390	6	its	its	PRON
ctmj-146	390	7	correlation	correlation	NOUN
ctmj-146	390	8	with	with	ADP
ctmj-146	390	9	clinical	clinical	ADJ
ctmj-146	390	10	survival	survival	NOUN
ctmj-146	390	11	are	be	AUX
ctmj-146	390	12	aided	aid	VERB
ctmj-146	390	13	by	by	ADP
ctmj-146	390	14	hbx	hbx	NOUN
ctmj-146	390	15	protein	protein	NOUN
ctmj-146	390	16	-	-	PUNCT
ctmj-146	390	17	induced	induce	VERB
ctmj-146	390	18	upregulation	upregulation	NOUN
ctmj-146	390	19	of	of	ADP
ctmj-146	390	20	s100a4	s100a4	ADJ
ctmj-146	390	21	expression	expression	NOUN
ctmj-146	390	22	.	.	PUNCT
ctmj-146	391	1	gene	gene	NOUN
ctmj-146	391	2	.	.	PUNCT
ctmj-146	392	1	749:144679	749:144679	NUM
ctmj-146	392	2	,	,	PUNCT
ctmj-146	392	3	2020	2020	NUM
ctmj-146	392	4	.	.	PUNCT
ctmj-146	393	1	67.the	67.the	DET
ctmj-146	393	2	authors	author	NOUN
ctmj-146	393	3	of	of	ADP
ctmj-146	393	4	the	the	DET
ctmj-146	393	5	article	article	NOUN
ctmj-146	393	6	are	be	AUX
ctmj-146	393	7	zhang	zhang	PROPN
ctmj-146	393	8	jh	jh	PROPN
ctmj-146	393	9	,	,	PUNCT
ctmj-146	393	10	hou	hou	PROPN
ctmj-146	393	11	ss	ss	PROPN
ctmj-146	393	12	,	,	PUNCT
ctmj-146	393	13	gu	gu	PROPN
ctmj-146	393	14	jc	jc	PROPN
ctmj-146	393	15	,	,	PUNCT
ctmj-146	393	16	and	and	CCONJ
ctmj-146	393	17	others	other	NOUN
ctmj-146	393	18	.	.	PUNCT
ctmj-146	394	1	inflammation	inflammation	NOUN
ctmj-146	394	2	of	of	ADP
ctmj-146	394	3	the	the	DET
ctmj-146	394	4	colon	colon	NOUN
ctmj-146	394	5	and	and	CCONJ
ctmj-146	394	6	carcinogenesis	carcinogenesis	NOUN
ctmj-146	394	7	of	of	ADP
ctmj-146	394	8	the	the	DET
ctmj-146	394	9	colon	colon	NOUN
ctmj-146	394	10	are	be	AUX
ctmj-146	394	11	both	both	PRON
ctmj-146	394	12	facilitated	facilitate	VERB
ctmj-146	394	13	by	by	ADP
ctmj-146	394	14	s100a4	s100a4	PROPN
ctmj-146	394	15	.	.	PUNCT
ctmj-146	394	16	immunology	immunology	NOUN
ctmj-146	394	17	in	in	ADP
ctmj-146	394	18	cancer	cancer	NOUN
ctmj-146	394	19	.	.	PUNCT
ctmj-146	395	1	(	(	PUNCT
ctmj-146	395	2	2018	2018	NUM
ctmj-146	395	3	,	,	PUNCT
ctmj-146	395	4	7/8	7/8	NUM
ctmj-146	395	5	,	,	PUNCT
ctmj-146	395	6	e1461311	e1461311	PROPN
ctmj-146	395	7	)	)	PUNCT
ctmj-146	395	8	.	.	PUNCT
ctmj-146	396	1	68.destek	68.destek	NUM
ctmj-146	396	2	s	s	X
ctmj-146	396	3	,	,	PUNCT
ctmj-146	396	4	gul	gul	PROPN
ctmj-146	396	5	vo	vo	X
ctmj-146	396	6	.	.	PROPN
ctmj-146	396	7	s100a4	s100a4	PROPN
ctmj-146	396	8	has	have	VERB
ctmj-146	396	9	the	the	DET
ctmj-146	396	10	potential	potential	NOUN
ctmj-146	396	11	to	to	PART
ctmj-146	396	12	be	be	AUX
ctmj-146	396	13	a	a	DET
ctmj-146	396	14	useful	useful	ADJ
ctmj-146	396	15	diagnostic	diagnostic	NOUN
ctmj-146	396	16	for	for	ADP
ctmj-146	396	17	colon	colon	NOUN
ctmj-146	396	18	cancer	cancer	NOUN
ctmj-146	396	19	prognosis	prognosis	NOUN
ctmj-146	396	20	and	and	CCONJ
ctmj-146	396	21	a	a	DET
ctmj-146	396	22	target	target	NOUN
ctmj-146	396	23	for	for	ADP
ctmj-146	396	24	treatment	treatment	NOUN
ctmj-146	396	25	.	.	PUNCT
ctmj-146	397	1	clinical	clinical	ADJ
ctmj-146	397	2	oncology	oncology	NOUN
ctmj-146	397	3	.	.	PUNCT
ctmj-146	398	1	the	the	DET
ctmj-146	398	2	year	year	NOUN
ctmj-146	398	3	2018	2018	NUM
ctmj-146	398	4	;	;	PUNCT
ctmj-146	398	5	the	the	DET
ctmj-146	398	6	year	year	NOUN
ctmj-146	398	7	2018:1828791	2018:1828791	NUM
ctmj-146	398	8	.	.	PUNCT
ctmj-146	399	1	69.our	69.our	NOUN
ctmj-146	399	2	group	group	NOUN
ctmj-146	399	3	includes	include	VERB
ctmj-146	399	4	fei	fei	PROPN
ctmj-146	399	5	f	f	PROPN
ctmj-146	399	6	,	,	PUNCT
ctmj-146	399	7	liu	liu	PROPN
ctmj-146	399	8	k	k	PROPN
ctmj-146	399	9	,	,	PUNCT
ctmj-146	399	10	li	li	PROPN
ctmj-146	399	11	cy	cy	PROPN
ctmj-146	399	12	,	,	PUNCT
ctmj-146	399	13	and	and	CCONJ
ctmj-146	399	14	others	other	NOUN
ctmj-146	399	15	.	.	PUNCT
ctmj-146	400	1	molecular	molecular	ADJ
ctmj-146	400	2	processes	process	NOUN
ctmj-146	400	3	by	by	ADP
ctmj-146	400	4	which	which	PRON
ctmj-146	400	5	s100a4	s100a4	ADJ
ctmj-146	400	6	governs	govern	VERB
ctmj-146	400	7	the	the	DET
ctmj-146	400	8	migration	migration	NOUN
ctmj-146	400	9	and	and	CCONJ
ctmj-146	400	10	invasion	invasion	NOUN
ctmj-146	400	11	of	of	ADP
ctmj-146	400	12	pgccs	pgccs	NOUN
ctmj-146	400	13	with	with	ADP
ctmj-146	400	14	their	their	PRON
ctmj-146	400	15	daughter	daughter	NOUN
ctmj-146	400	16	cells	cell	NOUN
ctmj-146	400	17	in	in	ADP
ctmj-146	400	18	human	human	ADJ
ctmj-146	400	19	colorectal	colorectal	ADJ
ctmj-146	400	20	cancer	cancer	NOUN
ctmj-146	400	21	.	.	PUNCT
ctmj-146	401	1	journal	journal	PROPN
ctmj-146	401	2	of	of	ADP
ctmj-146	401	3	oncology	oncology	NOUN
ctmj-146	401	4	.	.	PUNCT
ctmj-146	402	1	10:182	10:182	NUM
ctmj-146	402	2	.	.	PUNCT
ctmj-146	403	1	2020	2020	NUM
ctmj-146	403	2	.	.	PUNCT
ctmj-146	404	1	70.et	70.et	NUM
ctmj-146	404	2	al	al	PROPN
ctmj-146	404	3	.	.	PROPN
ctmj-146	404	4	klingelho€fer	klingelho€fer	PROPN
ctmj-146	404	5	,	,	PUNCT
ctmj-146	404	6	møller	møller	NOUN
ctmj-146	404	7	,	,	PUNCT
ctmj-146	404	8	sumer	sumer	PROPN
ctmj-146	404	9	,	,	PUNCT
ctmj-146	404	10	etc	etc	X
ctmj-146	404	11	.	.	X
ctmj-146	404	12	novel	novel	ADJ
ctmj-146	404	13	extracellular	extracellular	ADJ
ctmj-146	404	14	targets	target	NOUN
ctmj-146	404	15	for	for	ADP
ctmj-146	404	16	the	the	DET
ctmj-146	404	17	metastasis	metastasis	NOUN
ctmj-146	404	18	-	-	PUNCT
ctmj-146	404	19	promoting	promote	VERB
ctmj-146	404	20	s100a4	s100a4	ADJ
ctmj-146	404	21	protein	protein	NOUN
ctmj-146	404	22	include	include	VERB
ctmj-146	404	23	ligands	ligand	NOUN
ctmj-146	404	24	for	for	ADP
ctmj-146	404	25	the	the	DET
ctmj-146	404	26	epidermal	epidermal	ADJ
ctmj-146	404	27	growth	growth	NOUN
ctmj-146	404	28	factor	factor	NOUN
ctmj-146	404	29	receptor	receptor	NOUN
ctmj-146	404	30	.	.	PUNCT
ctmj-146	405	1	j.	j.	PROPN
ctmj-146	405	2	febs	febs	PROPN
ctmj-146	405	3	.	.	PUNCT
ctmj-146	406	1	2009	2009	NUM
ctmj-146	406	2	nov;276(20):5936–5948	nov;276(20):5936–5948	NOUN
ctmj-146	406	3	.	.	PUNCT
ctmj-146	407	1	71.authors	71.author	NOUN
ctmj-146	407	2	:	:	PUNCT
ctmj-146	407	3	pankratova	pankratova	PROPN
ctmj-146	407	4	s	s	X
ctmj-146	407	5	,	,	PUNCT
ctmj-146	407	6	klingelhofer	klingelhofer	PROPN
ctmj-146	407	7	j	j	PROPN
ctmj-146	407	8	,	,	PUNCT
ctmj-146	407	9	dmytriyeva	dmytriyeva	ADJ
ctmj-146	407	10	o	o	NOUN
ctmj-146	407	11	,	,	PUNCT
ctmj-146	407	12	and	and	CCONJ
ctmj-146	407	13	others	other	NOUN
ctmj-146	407	14	.	.	PUNCT
ctmj-146	408	1	neuronal	neuronal	ADJ
ctmj-146	408	2	survival	survival	NOUN
ctmj-146	408	3	is	be	AUX
ctmj-146	408	4	enhanced	enhance	VERB
ctmj-146	408	5	by	by	ADP
ctmj-146	408	6	the	the	DET
ctmj-146	408	7	s100a4	s100a4	ADJ
ctmj-146	408	8	protein	protein	NOUN
ctmj-146	408	9	,	,	PUNCT
ctmj-146	408	10	which	which	PRON
ctmj-146	408	11	communicates	communicate	VERB
ctmj-146	408	12	with	with	ADP
ctmj-146	408	13	the	the	DET
ctmj-146	408	14	erbb4	erbb4	NOUN
ctmj-146	408	15	receptor	receptor	NOUN
ctmj-146	408	16	.	.	PUNCT
ctmj-146	409	1	theranostics	theranostic	NOUN
ctmj-146	409	2	.	.	PUNCT
ctmj-146	410	1	the	the	DET
ctmj-146	410	2	current	current	ADJ
ctmj-146	410	3	version	version	NOUN
ctmj-146	410	4	is	be	AUX
ctmj-146	410	5	2018.8(14):3977e3990	2018.8(14):3977e3990	NUM
ctmj-146	410	6	.	.	PUNCT
ctmj-146	411	1	72.the	72.the	PRON
ctmj-146	411	2	function	function	NOUN
ctmj-146	411	3	of	of	ADP
ctmj-146	411	4	s100a4	s100a4	NOUN
ctmj-146	411	5	in	in	ADP
ctmj-146	411	6	metastasis	metastasis	NOUN
ctmj-146	411	7	as	as	SCONJ
ctmj-146	411	8	predicted	predict	VERB
ctmj-146	411	9	by	by	ADP
ctmj-146	411	10	models	model	NOUN
ctmj-146	411	11	of	of	ADP
ctmj-146	411	12	egf	egf	PROPN
ctmj-146	411	13	receptor	receptor	NOUN
ctmj-146	411	14	and	and	CCONJ
ctmj-146	411	15	matrix	matrix	NOUN
ctmj-146	411	16	metalloproteinase	metalloproteinase	NOUN
ctmj-146	411	17	deletion	deletion	NOUN
ctmj-146	411	18	and	and	CCONJ
ctmj-146	411	19	amplification	amplification	NOUN
ctmj-146	411	20	(	(	PUNCT
ctmj-146	411	21	buetti	buetti	NOUN
ctmj-146	411	22	-	-	PUNCT
ctmj-146	411	23	dinh	dinh	NOUN
ctmj-146	411	24	a	a	NOUN
ctmj-146	411	25	,	,	PUNCT
ctmj-146	411	26	pivkin	pivkin	NOUN
ctmj-146	411	27	iv	iv	ADP
ctmj-146	411	28	,	,	PUNCT
ctmj-146	411	29	friedman	friedman	PROPN
ctmj-146	411	30	r.	r.	PROPN
ctmj-146	411	31	)	)	PUNCT
ctmj-146	411	32	.	.	PUNCT
ctmj-146	412	1	biosystems	biosystems	PROPN
ctmj-146	412	2	chemistry	chemistry	NOUN
ctmj-146	412	3	.	.	PUNCT
ctmj-146	413	1	2015	2015	NUM
ctmj-146	413	2	,	,	PUNCT
ctmj-146	413	3	volume	volume	NOUN
ctmj-146	413	4	11	11	NUM
ctmj-146	413	5	,	,	PUNCT
ctmj-146	413	6	issue	issue	NOUN
ctmj-146	413	7	8	8	NUM
ctmj-146	413	8	,	,	PUNCT
ctmj-146	413	9	pages	page	NOUN
ctmj-146	413	10	2247–2254	2247–2254	NUM
ctmj-146	413	11	.	.	PUNCT
ctmj-146	414	1	73.amlexanox	73.amlexanox	NUM
ctmj-146	414	2	reduces	reduce	VERB
ctmj-146	414	3	cell	cell	NOUN
ctmj-146	414	4	proliferation	proliferation	NOUN
ctmj-146	414	5	by	by	ADP
ctmj-146	414	6	blocking	block	VERB
ctmj-146	414	7	the	the	DET
ctmj-146	414	8	interaction	interaction	NOUN
ctmj-146	414	9	between	between	ADP
ctmj-146	414	10	s100a4	s100a4	ADJ
ctmj-146	414	11	and	and	CCONJ
ctmj-146	414	12	epidermal	epidermal	ADJ
ctmj-146	414	13	growth	growth	NOUN
ctmj-146	414	14	factor	factor	NOUN
ctmj-146	414	15	(	(	PUNCT
ctmj-146	414	16	cho	cho	PROPN
ctmj-146	414	17	cc	cc	PROPN
ctmj-146	414	18	,	,	PUNCT
ctmj-146	414	19	chou	chou	PROPN
ctmj-146	414	20	rh	rh	PROPN
ctmj-146	414	21	,	,	PUNCT
ctmj-146	414	22	yu	yu	PROPN
ctmj-146	414	23	c.	c.	PROPN
ctmj-146	414	24	)	)	PUNCT
ctmj-146	414	25	.	.	PUNCT
ctmj-146	415	1	the	the	DET
ctmj-146	415	2	journal	journal	PROPN
ctmj-146	415	3	plos	plo	VERB
ctmj-146	415	4	one	one	NUM
ctmj-146	415	5	.	.	PUNCT
ctmj-146	416	1	published	publish	VERB
ctmj-146	416	2	in	in	ADP
ctmj-146	416	3	2016	2016	NUM
ctmj-146	416	4	with	with	ADP
ctmj-146	416	5	the	the	DET
ctmj-146	416	6	doi	doi	NOUN
ctmj-146	416	7	:	:	PUNCT
ctmj-146	416	8	10.1136	10.1136	NUM
ctmj-146	416	9	/	/	SYM
ctmj-146	416	10	med.11(8)1681	med.11(8)1681	NOUN
ctmj-146	416	11	.	.	PUNCT
ctmj-146	417	1	74.the	74.the	DET
ctmj-146	417	2	transactivation	transactivation	NOUN
ctmj-146	417	3	domain	domain	NOUN
ctmj-146	417	4	of	of	ADP
ctmj-146	417	5	p53	p53	NOUN
ctmj-146	417	6	in	in	ADP
ctmj-146	417	7	association	association	NOUN
ctmj-146	417	8	with	with	ADP
ctmj-146	417	9	s100a4	s100a4	PROPN
ctmj-146	417	10	was	be	AUX
ctmj-146	417	11	crystallized	crystallize	VERB
ctmj-146	417	12	with	with	ADP
ctmj-146	417	13	the	the	DET
ctmj-146	417	14	help	help	NOUN
ctmj-146	417	15	of	of	ADP
ctmj-146	417	16	annexin	annexin	PROPN
ctmj-146	417	17	a2	a2	PROPN
ctmj-146	417	18	,	,	PUNCT
ctmj-146	417	19	according	accord	VERB
ctmj-146	417	20	to	to	ADP
ctmj-146	417	21	research	research	NOUN
ctmj-146	417	22	by	by	ADP
ctmj-146	417	23	ecse'di	ecse'di	PROPN
ctmj-146	417	24	,	,	PUNCT
ctmj-146	417	25	go'gl	go'gl	PROPN
ctmj-146	417	26	,	,	PUNCT
ctmj-146	417	27	ho'f	ho'f	NOUN
ctmj-146	417	28	,	,	PUNCT
ctmj-146	417	29	kiss	kiss	ADJ
ctmj-146	417	30	,	,	PUNCT
ctmj-146	417	31	harmat	harmat	ADJ
ctmj-146	417	32	,	,	PUNCT
ctmj-146	417	33	and	and	CCONJ
ctmj-146	417	34	nyitray	nyitray	NOUN
ctmj-146	417	35	.	.	PUNCT
ctmj-146	418	1	structure	structure	NOUN
ctmj-146	418	2	.	.	PUNCT
ctmj-146	419	1	the	the	DET
ctmj-146	419	2	year	year	NOUN
ctmj-146	419	3	2020;28(8):943–953	2020;28(8):943–953	NUM
ctmj-146	419	4	.	.	PUNCT
ctmj-146	420	1	75.design	75.design	NUM
ctmj-146	420	2	,	,	PUNCT
ctmj-146	420	3	synthesis	synthesis	NOUN
ctmj-146	420	4	,	,	PUNCT
ctmj-146	420	5	and	and	CCONJ
ctmj-146	420	6	biological	biological	ADJ
ctmj-146	420	7	research	research	NOUN
ctmj-146	420	8	of	of	ADP
ctmj-146	420	9	hybrid	hybrid	ADJ
ctmj-146	420	10	therapeutic	therapeutic	ADJ
ctmj-146	420	11	candidates	candidate	NOUN
ctmj-146	420	12	of	of	ADP
ctmj-146	420	13	nitric	nitric	ADJ
ctmj-146	420	14	oxide	oxide	NOUN
ctmj-146	420	15	releasing	release	VERB
ctmj-146	420	16	cucurbitacin	cucurbitacin	PROPN
ctmj-146	420	17	-	-	PUNCT
ctmj-146	420	18	inspired	inspire	VERB
ctmj-146	420	19	estrone	estrone	NOUN
ctmj-146	420	20	analogs	analog	NOUN
ctmj-146	420	21	for	for	ADP
ctmj-146	420	22	treatment	treatment	NOUN
ctmj-146	420	23	of	of	ADP
ctmj-146	420	24	hepatocellular	hepatocellular	ADJ
ctmj-146	420	25	carcinoma	carcinoma	NOUN
ctmj-146	420	26	were	be	AUX
ctmj-146	420	27	conducted	conduct	VERB
ctmj-146	420	28	by	by	ADP
ctmj-146	420	29	abou	abou	PROPN
ctmj-146	420	30	-	-	PUNCT
ctmj-146	420	31	salim	salim	PROPN
ctmj-146	420	32	ma	ma	PROPN
ctmj-146	420	33	,	,	PUNCT
ctmj-146	420	34	shaaban	shaaban	PROPN
ctmj-146	420	35	ma	ma	PROPN
ctmj-146	420	36	,	,	PUNCT
ctmj-146	420	37	abd	abd	PROPN
ctmj-146	420	38	el	el	PROPN
ctmj-146	420	39	hameid	hameid	PROPN
ctmj-146	420	40	mk	mk	PROPN
ctmj-146	420	41	,	,	PUNCT
ctmj-146	420	42	elshaier	elshaier	PROPN
ctmj-146	420	43	yamm	yamm	PROPN
ctmj-146	420	44	,	,	PUNCT
ctmj-146	420	45	and	and	CCONJ
ctmj-146	420	46	halaweish	halaweish	PROPN
ctmj-146	420	47	f.	f.	PROPN
ctmj-146	420	48	inorganic	inorganic	PROPN
ctmj-146	420	49	chemistry	chemistry	NOUN
ctmj-146	420	50	.	.	PUNCT
ctmj-146	421	1	published	publish	VERB
ctmj-146	421	2	in	in	ADP
ctmj-146	421	3	2019	2019	NUM
ctmj-146	421	4	with	with	ADP
ctmj-146	421	5	the	the	DET
ctmj-146	421	6	doi	doi	NOUN
ctmj-146	421	7	:	:	PUNCT
ctmj-146	421	8	85:515e533	85:515e533	NUM
ctmj-146	421	9	.	.	PUNCT
ctmj-146	422	1	76.a	76.a	NUM
ctmj-146	422	2	group	group	NOUN
ctmj-146	422	3	of	of	ADP
ctmj-146	422	4	researchers	researcher	NOUN
ctmj-146	422	5	including	include	VERB
ctmj-146	422	6	peng	peng	PROPN
ctmj-146	422	7	,	,	PUNCT
ctmj-146	422	8	he	he	PRON
ctmj-146	422	9	,	,	PUNCT
ctmj-146	422	10	and	and	CCONJ
ctmj-146	422	11	xu	xu	PROPN
ctmj-146	422	12	performed	perform	VERB
ctmj-146	422	13	the	the	DET
ctmj-146	422	14	study	study	NOUN
ctmj-146	422	15	.	.	PUNCT
ctmj-146	423	1	ginsenoside	ginsenoside	ADV
ctmj-146	423	2	20(s)protopanaxadiol	20(s)protopanaxadiol	NUM
ctmj-146	423	3	targets	target	VERB
ctmj-146	423	4	the	the	DET
ctmj-146	423	5	egfr	egfr	ADV
ctmj-146	423	6	-	-	PUNCT
ctmj-146	423	7	mediated	mediate	VERB
ctmj-146	423	8	mapk	mapk	NOUN
ctmj-146	423	9	pathway	pathway	NOUN
ctmj-146	423	10	and	and	CCONJ
ctmj-146	423	11	suppresses	suppress	VERB
ctmj-146	423	12	the	the	DET
ctmj-146	423	13	spread	spread	NOUN
ctmj-146	423	14	of	of	ADP
ctmj-146	423	15	triple	triple	ADJ
ctmj-146	423	16	-	-	PUNCT
ctmj-146	423	17	negative	negative	ADJ
ctmj-146	423	18	breast	breast	NOUN
ctmj-146	423	19	cancer	cancer	NOUN
ctmj-146	423	20	in	in	ADP
ctmj-146	423	21	vivo	vivo	NOUN
ctmj-146	423	22	.	.	PUNCT
ctmj-146	424	1	pharmaceutical	pharmaceutical	ADJ
ctmj-146	424	2	research	research	NOUN
ctmj-146	424	3	.	.	PUNCT
ctmj-146	425	1	2019;142:1–13	2019;142:1–13	NUM
ctmj-146	425	2	.	.	PUNCT
ctmj-146	426	1	77	77	NUM
ctmj-146	426	2	.	.	PUNCT
ctmj-146	427	1	a.this	a.this	DET
ctmj-146	427	2	work	work	NOUN
ctmj-146	427	3	is	be	AUX
ctmj-146	427	4	by	by	ADP
ctmj-146	427	5	hong	hong	PROPN
ctmj-146	427	6	sh	sh	PROPN
ctmj-146	427	7	,	,	PUNCT
ctmj-146	427	8	ku	ku	PROPN
ctmj-146	427	9	jm	jm	PROPN
ctmj-146	427	10	,	,	PUNCT
ctmj-146	427	11	lim	lim	PROPN
ctmj-146	427	12	ys	ys	PROPN
ctmj-146	427	13	,	,	PUNCT
ctmj-146	427	14	,	,	PUNCT
ctmj-146	427	15	and	and	CCONJ
ctmj-146	427	16	others	other	NOUN
ctmj-146	427	17	.	.	PUNCT
ctmj-146	428	1	by	by	ADP
ctmj-146	428	2	inhibiting	inhibit	VERB
ctmj-146	428	3	egf	egf	NOUN
ctmj-146	428	4	binding	bind	VERB
ctmj-146	428	5	to	to	ADP
ctmj-146	428	6	egfr	egfr	VERB
ctmj-146	428	7	and	and	CCONJ
ctmj-146	428	8	triggering	trigger	VERB
ctmj-146	428	9	cell	cell	NOUN
ctmj-146	428	10	death	death	NOUN
ctmj-146	428	11	in	in	ADP
ctmj-146	428	12	nsclcs	nsclcs	NOUN
ctmj-146	428	13	,	,	PUNCT
ctmj-146	428	14	cucurbitacin	cucurbitacin	PROPN
ctmj-146	428	15	d	d	PROPN
ctmj-146	428	16	circumvents	circumvent	VERB
ctmj-146	428	17	gefitinib	gefitinib	NOUN
ctmj-146	428	18	resistance	resistance	NOUN
ctmj-146	428	19	.	.	PUNCT
ctmj-146	429	1	journal	journal	PROPN
ctmj-146	429	2	of	of	ADP
ctmj-146	429	3	oncology	oncology	NOUN
ctmj-146	429	4	.	.	PUNCT
ctmj-146	430	1	the	the	DET
ctmj-146	430	2	year	year	NOUN
ctmj-146	430	3	2020;10:62	2020;10:62	NUM
ctmj-146	430	4	.	.	PUNCT
ctmj-146	431	1	78.through	78.through	X
ctmj-146	431	2	its	its	PRON
ctmj-146	431	3	targeting	targeting	NOUN
ctmj-146	431	4	of	of	ADP
ctmj-146	431	5	the	the	DET
ctmj-146	431	6	epidermal	epidermal	ADJ
ctmj-146	431	7	growth	growth	NOUN
ctmj-146	431	8	factor	factor	NOUN
ctmj-146	431	9	receptor	receptor	NOUN
ctmj-146	431	10	,	,	PUNCT
ctmj-146	431	11	20(s)-protopanaxadiol	20(s)-protopanaxadiol	NOUN
ctmj-146	431	12	inhibits	inhibit	VERB
ctmj-146	431	13	cell	cell	NOUN
ctmj-146	431	14	cycle	cycle	NOUN
ctmj-146	431	15	progression	progression	NOUN
ctmj-146	431	16	(	(	PUNCT
ctmj-146	431	17	zhang	zhang	PROPN
ctmj-146	431	18	th	th	PROPN
ctmj-146	431	19	,	,	PUNCT
ctmj-146	431	20	liang	liang	PROPN
ctmj-146	431	21	y	y	PROPN
ctmj-146	431	22	,	,	PUNCT
ctmj-146	431	23	zuo	zuo	PROPN
ctmj-146	431	24	p	p	PROPN
ctmj-146	431	25	,	,	PUNCT
ctmj-146	431	26	et	et	PROPN
ctmj-146	431	27	al	al	PROPN
ctmj-146	431	28	.	.	PROPN
ctmj-146	431	29	)	)	PUNCT
ctmj-146	431	30	.	.	PUNCT
ctmj-146	432	1	nutritional	nutritional	ADJ
ctmj-146	432	2	chemistry	chemistry	NOUN
ctmj-146	432	3	and	and	CCONJ
ctmj-146	432	4	toxicology	toxicology	NOUN
ctmj-146	432	5	.	.	PUNCT
ctmj-146	433	1	the	the	DET
ctmj-146	433	2	reference	reference	NOUN
ctmj-146	433	3	number	number	NOUN
ctmj-146	433	4	is	be	AUX
ctmj-146	433	5	2020;135:111017	2020;135:111017	NUM
ctmj-146	433	6	.	.	PUNCT
ctmj-146	434	1	79.a	79.a	NUM
ctmj-146	434	2	group	group	NOUN
ctmj-146	434	3	of	of	ADP
ctmj-146	434	4	researchers	researcher	NOUN
ctmj-146	434	5	including	include	VERB
ctmj-146	434	6	huang	huang	PROPN
ctmj-146	434	7	hb	hb	PROPN
ctmj-146	434	8	,	,	PUNCT
ctmj-146	434	9	zhang	zhang	PROPN
ctmj-146	434	10	gg	gg	PROPN
ctmj-146	434	11	,	,	PUNCT
ctmj-146	434	12	zhou	zhou	PROPN
ctmj-146	434	13	yq	yq	PROPN
ctmj-146	434	14	,	,	PUNCT
ctmj-146	434	15	...	...	PUNCT
ctmj-146	434	16	a	a	DET
ctmj-146	434	17	technique	technique	NOUN
ctmj-146	434	18	for	for	ADP
ctmj-146	434	19	finding	find	VERB
ctmj-146	434	20	the	the	DET
ctmj-146	434	21	proteins	protein	NOUN
ctmj-146	434	22	that	that	PRON
ctmj-146	434	23	chemopreventive	chemopreventive	ADJ
ctmj-146	434	24	drugs	drug	NOUN
ctmj-146	434	25	target	target	VERB
ctmj-146	434	26	via	via	ADP
ctmj-146	434	27	reverse	reverse	ADJ
ctmj-146	434	28	screening	screening	NOUN
ctmj-146	434	29	.	.	PUNCT
ctmj-146	435	1	chem	chem	NOUN
ctmj-146	435	2	.	.	PUNCT
ctmj-146	436	1	front	front	NOUN
ctmj-146	436	2	.	.	PUNCT
ctmj-146	437	1	138	138	NUM
ctmj-146	437	2	(	(	PUNCT
ctmj-146	437	3	2018;6	2018;6	NOUN
ctmj-146	437	4	:)	:)	NOUN
ctmj-146	437	5	.	.	PUNCT
ctmj-146	438	1	80.new	80.new	PROPN
ctmj-146	438	2	approaches	approach	VERB
ctmj-146	438	3	to	to	ADP
ctmj-146	438	4	drug	drug	NOUN
ctmj-146	438	5	discovery	discovery	NOUN
ctmj-146	438	6	by	by	ADP
ctmj-146	438	7	molecular	molecular	ADJ
ctmj-146	438	8	docking	docking	NOUN
ctmj-146	438	9	,	,	PUNCT
ctmj-146	438	10	by	by	ADP
ctmj-146	438	11	pinzi	pinzi	PROPN
ctmj-146	438	12	l.	l.	PROPN
ctmj-146	438	13	and	and	CCONJ
ctmj-146	438	14	rastelli	rastelli	PROPN
ctmj-146	438	15	g.	g.	PROPN
ctmj-146	438	16	int	int	PROPN
ctmj-146	438	17	j	j	PROPN
ctmj-146	438	18	mol	mol	ADP
ctmj-146	438	19	sci	sci	PROPN
ctmj-146	438	20	.	.	PUNCT
ctmj-146	439	1	the	the	DET
ctmj-146	439	2	current	current	ADJ
ctmj-146	439	3	version	version	NOUN
ctmj-146	439	4	is	be	AUX
ctmj-146	439	5	20(18):4331	20(18):4331	NUM
ctmj-146	439	6	.	.	PUNCT
ctmj-146	440	1	81.wang	81.wang	NUM
ctmj-146	441	1	w	w	PROPN
ctmj-146	441	2	,	,	PUNCT
ctmj-146	441	3	xiong	xiong	PROPN
ctmj-146	441	4	xh	xh	PROPN
ctmj-146	441	5	,	,	PUNCT
ctmj-146	441	6	li	li	PROPN
ctmj-146	441	7	x	x	PROPN
ctmj-146	441	8	,	,	PUNCT
ctmj-146	441	9	zhang	zhang	PROPN
ctmj-146	441	10	qy	qy	PROPN
ctmj-146	441	11	,	,	PUNCT
ctmj-146	441	12	yang	yang	PROPN
ctmj-146	441	13	wt	wt	PROPN
ctmj-146	441	14	,	,	PUNCT
ctmj-146	441	15	du	du	PROPN
ctmj-146	441	16	lf	lf	PROPN
ctmj-146	441	17	.	.	PUNCT
ctmj-146	441	18	in	in	ADP
ctmj-146	441	19	-	-	PUNCT
ctmj-146	441	20	situ	situ	NOUN
ctmj-146	441	21	study	study	NOUN
ctmj-146	441	22	of	of	ADP
ctmj-146	441	23	epigallocatechin-3gallate	epigallocatechin-3gallate	PROPN
ctmj-146	441	24	's	's	PART
ctmj-146	441	25	anti	anti	ADJ
ctmj-146	441	26	-	-	ADJ
ctmj-146	441	27	cancer	cancer	ADJ
ctmj-146	441	28	mechanisms	mechanism	NOUN
ctmj-146	441	29	.	.	PUNCT
ctmj-146	442	1	small	small	ADJ
ctmj-146	442	2	biological	biological	ADJ
ctmj-146	442	3	units	unit	NOUN
ctmj-146	442	4	.	.	PUNCT
ctmj-146	443	1	the	the	DET
ctmj-146	443	2	year	year	NOUN
ctmj-146	443	3	2019;24(7):1445	2019;24(7):1445	NUM
ctmj-146	443	4	.	.	PUNCT
ctmj-146	444	1	82.researchers	82.researchers	NUM
ctmj-146	444	2	ty	ty	NUM
ctmj-146	444	3	han	han	PROPN
ctmj-146	444	4	,	,	PUNCT
ctmj-146	444	5	jj	jj	PROPN
ctmj-146	444	6	yong	yong	PROPN
ctmj-146	444	7	,	,	PUNCT
ctmj-146	444	8	o	o	PROPN
ctmj-146	444	9	liu	liu	PROPN
ctmj-146	444	10	,	,	PUNCT
ctmj-146	444	11	xs	xs	PROPN
ctmj-146	444	12	gu	gu	PROPN
ctmj-146	444	13	,	,	PUNCT
ctmj-146	444	14	wn	wn	PROPN
ctmj-146	444	15	zhang	zhang	PROPN
ctmj-146	444	16	,	,	PUNCT
ctmj-146	444	17	and	and	CCONJ
ctmj-146	444	18	jh	jh	PROPN
ctmj-146	444	19	yang	yang	PROPN
ctmj-146	444	20	prepared	prepare	VERB
ctmj-146	444	21	and	and	CCONJ
ctmj-146	444	22	characterized	characterize	VERB
ctmj-146	444	23	cyclovirobuxine	cyclovirobuxine	NOUN
ctmj-146	444	24	d	d	NOUN
ctmj-146	444	25	nanosuspensions	nanosuspension	NOUN
ctmj-146	444	26	by	by	ADP
ctmj-146	444	27	wet	wet	ADJ
ctmj-146	444	28	milling	milling	NOUN
ctmj-146	444	29	.	.	PUNCT
ctmj-146	445	1	applied	apply	VERB
ctmj-146	445	2	thermology	thermology	NOUN
ctmj-146	445	3	journal	journal	NOUN
ctmj-146	445	4	.	.	PUNCT
ctmj-146	446	1	139:1959–1970	139:1959–1970	NUM
ctmj-146	446	2	in	in	ADP
ctmj-146	446	3	2020	2020	NUM
ctmj-146	446	4	.	.	PUNCT
ctmj-146	447	1	83.participants	83.participant	NOUN
ctmj-146	447	2	include	include	VERB
ctmj-146	447	3	dey	dey	PROPN
ctmj-146	447	4	,	,	PUNCT
ctmj-146	447	5	kundu	kundu	NOUN
ctmj-146	447	6	,	,	PUNCT
ctmj-146	447	7	chakraborty	chakraborty	NOUN
ctmj-146	447	8	,	,	PUNCT
ctmj-146	447	9	and	and	CCONJ
ctmj-146	447	10	others	other	NOUN
ctmj-146	447	11	.	.	PUNCT
ctmj-146	448	1	what	what	PRON
ctmj-146	448	2	the	the	DET
ctmj-146	448	3	future	future	NOUN
ctmj-146	448	4	holds	hold	VERB
ctmj-146	448	5	for	for	ADP
ctmj-146	448	6	the	the	DET
ctmj-146	448	7	cancer	cancer	NOUN
ctmj-146	448	8	therapeutic	therapeutic	ADJ
ctmj-146	448	9	potential	potential	NOUN
ctmj-146	448	10	of	of	ADP
ctmj-146	448	11	steroidal	steroidal	NOUN
ctmj-146	448	12	alkaloids	alkaloid	NOUN
ctmj-146	448	13	:	:	PUNCT
ctmj-146	448	14	present	present	ADJ
ctmj-146	448	15	trends	trend	NOUN
ctmj-146	448	16	and	and	CCONJ
ctmj-146	448	17	predictions	prediction	NOUN
ctmj-146	448	18	.	.	PUNCT
ctmj-146	449	1	american	american	ADJ
ctmj-146	449	2	journal	journal	PROPN
ctmj-146	449	3	of	of	ADP
ctmj-146	449	4	cancer	cancer	NOUN
ctmj-146	449	5	.	.	PUNCT
ctmj-146	450	1	145(7	145(7	NUM
ctmj-146	450	2	):	):	PUNCT
ctmj-146	450	3	1731–1744	1731–1744	NUM
ctmj-146	450	4	,	,	PUNCT
ctmj-146	450	5	2019	2019	NUM
ctmj-146	450	6	.	.	PUNCT