id	sid	tid	token	lemma	pos
ctmj-148	1	1	identification	identification	NOUN
ctmj-148	1	2	of	of	ADP
ctmj-148	1	3	the	the	DET
ctmj-148	1	4	multiple	multiple	ADJ
ctmj-148	1	5	bioactive	bioactive	ADJ
ctmj-148	1	6	derivatives	derivative	NOUN
ctmj-148	1	7	and	and	CCONJ
ctmj-148	1	8	their	their	PRON
ctmj-148	1	9	endogenous	endogenous	ADJ
ctmj-148	1	10	molecular	molecular	ADJ
ctmj-148	1	11	targets	target	NOUN
ctmj-148	1	12	that	that	PRON
ctmj-148	1	13	may	may	AUX
ctmj-148	1	14	mediate	mediate	VERB
ctmj-148	1	15	the	the	DET
ctmj-148	1	16	laxative	laxative	ADJ
ctmj-148	1	17	effect	effect	NOUN
ctmj-148	1	18	of	of	ADP
ctmj-148	1	19	rhubarb	rhubarb	NOUN
ctmj-148	1	20	in	in	ADP
ctmj-148	1	21	rats	rat	NOUN
ctmj-148	1	22	ctmj	ctmj	NOUN
ctmj-148	1	23	|	|	ADV
ctmj-148	1	24	traditionalmedicinejournals.com	traditionalmedicinejournals.com	X
ctmj-148	1	25	issn	issn	PROPN
ctmj-148	1	26	:	:	PUNCT
ctmj-148	1	27	2693	2693	NUM
ctmj-148	1	28	6356	6356	NUM
ctmj-148	1	29	2024	2024	NUM
ctmj-148	1	30	|	|	ADV
ctmj-148	1	31	vol	vol	NOUN
ctmj-148	1	32	7	7	NUM
ctmj-148	1	33	|	|	NOUN
ctmj-148	1	34	issue	issue	VERB
ctmj-148	1	35	1	1	NUM
ctmj-148	1	36	chinese	chinese	ADJ
ctmj-148	1	37	traditional	traditional	ADJ
ctmj-148	1	38	medicine	medicine	NOUN
ctmj-148	1	39	journal	journal	NOUN
ctmj-148	1	40	|	|	ADV
ctmj-148	1	41	2024	2024	NUM
ctmj-148	1	42	|	|	ADV
ctmj-148	1	43	vol	vol	NOUN
ctmj-148	1	44	7	7	NUM
ctmj-148	1	45	|	|	NOUN
ctmj-148	1	46	issue	issue	VERB
ctmj-148	1	47	1	1	NUM
ctmj-148	1	48	identification	identification	NOUN
ctmj-148	1	49	of	of	ADP
ctmj-148	1	50	the	the	DET
ctmj-148	1	51	multiple	multiple	ADJ
ctmj-148	1	52	bioactive	bioactive	ADJ
ctmj-148	1	53	derivatives	derivative	NOUN
ctmj-148	1	54	and	and	CCONJ
ctmj-148	1	55	their	their	PRON
ctmj-148	1	56	endogenous	endogenous	ADJ
ctmj-148	1	57	molecular	molecular	ADJ
ctmj-148	1	58	targets	target	NOUN
ctmj-148	1	59	that	that	PRON
ctmj-148	1	60	may	may	AUX
ctmj-148	1	61	mediate	mediate	VERB
ctmj-148	1	62	the	the	DET
ctmj-148	1	63	laxative	laxative	ADJ
ctmj-148	1	64	effect	effect	NOUN
ctmj-148	1	65	of	of	ADP
ctmj-148	1	66	rhubarb	rhubarb	NOUN
ctmj-148	1	67	in	in	ADP
ctmj-148	1	68	rats	rat	NOUN
ctmj-148	1	69	xie	xie	PROPN
ctmj-148	1	70	,	,	PUNCT
ctmj-148	1	71	ying	ying	PROPN
ctmj-148	1	72	,	,	PUNCT
ctmj-148	1	73	ganqa	ganqa	ADJ
ctmj-148	1	74	luo	luo	PROPN
ctmj-148	1	75	,	,	PUNCT
ctmj-148	1	76	zhou	zhou	PROPN
ctmj-148	1	77	,	,	PUNCT
ctmj-148	1	78	jiayan	jiayan	PROPN
ctmj-148	1	79	miao	miao	PROPN
ctmj-148	1	80	,	,	PUNCT
ctmj-148	1	81	tang	tang	PROPN
ctmj-148	1	82	,	,	PUNCT
ctmj-148	1	83	qin	qin	PROPN
ctmj-148	1	84	,	,	PUNCT
ctmj-148	1	85	guan	guan	PROPN
ctmj-148	1	86	,	,	PUNCT
ctmj-148	1	87	xiaoyan	xiaoyan	PROPN
ctmj-148	1	88	*	*	PUNCT
ctmj-148	2	1	school	school	NOUN
ctmj-148	2	2	of	of	ADP
ctmj-148	2	3	chinese	chinese	PROPN
ctmj-148	2	4	materia	materia	PROPN
ctmj-148	2	5	medica	medica	PROPN
ctmj-148	2	6	,	,	PUNCT
ctmj-148	2	7	beijing	beijing	PROPN
ctmj-148	2	8	university	university	PROPN
ctmj-148	2	9	of	of	ADP
ctmj-148	2	10	chinese	chinese	ADJ
ctmj-148	2	11	medicine	medicine	NOUN
ctmj-148	2	12	,	,	PUNCT
ctmj-148	2	13	beijing	beijing	PROPN
ctmj-148	2	14	,	,	PUNCT
ctmj-148	2	15	102488	102488	NUM
ctmj-148	2	16	,	,	PUNCT
ctmj-148	2	17	china	china	PROPN
ctmj-148	2	18	keywords	keyword	NOUN
ctmj-148	2	19	:	:	PUNCT
ctmj-148	2	20	rhubarb	rhubarb	NOUN
ctmj-148	2	21	laxative	laxative	ADJ
ctmj-148	2	22	anthraquinones	anthraquinone	NOUN
ctmj-148	2	23	anthrones	anthrone	NOUN
ctmj-148	2	24	c	c	NOUN
ctmj-148	2	25	-	-	PUNCT
ctmj-148	2	26	kit	kit	NOUN
ctmj-148	2	27	aquaporin-3	aquaporin-3	DET
ctmj-148	2	28	introduction	introduction	NOUN
ctmj-148	2	29	the	the	DET
ctmj-148	2	30	chinese	chinese	ADJ
ctmj-148	2	31	herbal	herbal	ADJ
ctmj-148	2	32	remedy	remedy	NOUN
ctmj-148	2	33	rhubarb	rhubarb	NOUN
ctmj-148	2	34	,	,	PUNCT
ctmj-148	2	35	scientifically	scientifically	ADV
ctmj-148	2	36	known	know	VERB
ctmj-148	2	37	as	as	ADP
ctmj-148	2	38	rheum	rheum	NOUN
ctmj-148	2	39	tanguticum	tanguticum	ADJ
ctmj-148	2	40	maxim	maxim	NOUN
ctmj-148	2	41	.	.	PUNCT
ctmj-148	3	1	ex	ex	X
ctmj-148	3	2	balf	balf	PROPN
ctmj-148	3	3	.	.	PUNCT
ctmj-148	3	4	,	,	PUNCT
ctmj-148	3	5	is	be	AUX
ctmj-148	3	6	a	a	DET
ctmj-148	3	7	popular	popular	ADJ
ctmj-148	3	8	choice	choice	NOUN
ctmj-148	3	9	for	for	ADP
ctmj-148	3	10	relieving	relieve	VERB
ctmj-148	3	11	constipation.1	constipation.1	NOUN
ctmj-148	3	12	,	,	PUNCT
ctmj-148	3	13	2	2	NUM
ctmj-148	3	14	sennoside	sennoside	NOUN
ctmj-148	3	15	a	a	PRON
ctmj-148	3	16	,	,	PUNCT
ctmj-148	3	17	the	the	DET
ctmj-148	3	18	main	main	ADJ
ctmj-148	3	19	laxative	laxative	NOUN
ctmj-148	3	20	component	component	NOUN
ctmj-148	3	21	of	of	ADP
ctmj-148	3	22	rhubarb	rhubarb	NOUN
ctmj-148	3	23	,	,	PUNCT
ctmj-148	3	24	is	be	AUX
ctmj-148	3	25	metabolised	metabolise	VERB
ctmj-148	3	26	to	to	AUX
ctmj-148	3	27	rheinanthrone	rheinanthrone	VERB
ctmj-148	3	28	by	by	ADP
ctmj-148	3	29	gut	gut	NOUN
ctmj-148	3	30	abstract	abstract	NOUN
ctmj-148	3	31	—	—	PUNCT
ctmj-148	3	32	the	the	DET
ctmj-148	3	33	goal	goal	NOUN
ctmj-148	3	34	of	of	ADP
ctmj-148	3	35	this	this	DET
ctmj-148	3	36	study	study	NOUN
ctmj-148	3	37	is	be	AUX
ctmj-148	3	38	to	to	PART
ctmj-148	3	39	use	use	VERB
ctmj-148	3	40	a	a	DET
ctmj-148	3	41	bioinformatics	bioinformatics	NOUN
ctmj-148	3	42	and	and	CCONJ
ctmj-148	3	43	in	in	ADP
ctmj-148	3	44	vivo	vivo	NOUN
ctmj-148	3	45	method	method	NOUN
ctmj-148	3	46	to	to	PART
ctmj-148	3	47	figure	figure	VERB
ctmj-148	3	48	out	out	ADP
ctmj-148	3	49	how	how	SCONJ
ctmj-148	3	50	rhubarb	rhubarb	NOUN
ctmj-148	3	51	(	(	PUNCT
ctmj-148	3	52	rheum	rheum	NOUN
ctmj-148	3	53	tanguticum	tanguticum	ADJ
ctmj-148	3	54	maxim	maxim	NOUN
ctmj-148	3	55	.	.	PUNCT
ctmj-148	4	1	ex	ex	X
ctmj-148	4	2	balf	balf	NOUN
ctmj-148	4	3	.	.	PUNCT
ctmj-148	4	4	)	)	PUNCT
ctmj-148	4	5	causes	cause	VERB
ctmj-148	4	6	rats	rat	NOUN
ctmj-148	4	7	to	to	PART
ctmj-148	4	8	go	go	VERB
ctmj-148	4	9	to	to	ADP
ctmj-148	4	10	the	the	DET
ctmj-148	4	11	toilet	toilet	NOUN
ctmj-148	4	12	more	more	ADV
ctmj-148	4	13	often	often	ADV
ctmj-148	4	14	.	.	PUNCT
ctmj-148	5	1	methods	method	NOUN
ctmj-148	5	2	:	:	PUNCT
ctmj-148	5	3	using	use	VERB
ctmj-148	5	4	high	high	ADJ
ctmj-148	5	5	-	-	PUNCT
ctmj-148	5	6	performance	performance	NOUN
ctmj-148	5	7	liquid	liquid	ADJ
ctmj-148	5	8	chromatography	chromatography	NOUN
ctmj-148	5	9	in	in	ADP
ctmj-148	5	10	conjunction	conjunction	NOUN
ctmj-148	5	11	with	with	ADP
ctmj-148	5	12	linear	linear	ADJ
ctmj-148	5	13	ion	ion	NOUN
ctmj-148	5	14	-	-	PUNCT
ctmj-148	5	15	trap	trap	NOUN
ctmj-148	5	16	quadrupole	quadrupole	NOUN
ctmj-148	5	17	orbitrap	orbitrap	ADJ
ctmj-148	5	18	high	high	ADJ
ctmj-148	5	19	-	-	PUNCT
ctmj-148	5	20	resolution	resolution	NOUN
ctmj-148	5	21	mass	mass	NOUN
ctmj-148	5	22	spectrometry	spectrometry	NOUN
ctmj-148	5	23	,	,	PUNCT
ctmj-148	5	24	substances	substance	NOUN
ctmj-148	5	25	originating	originate	VERB
ctmj-148	5	26	from	from	ADP
ctmj-148	5	27	rhubarb	rhubarb	NOUN
ctmj-148	5	28	that	that	PRON
ctmj-148	5	29	were	be	AUX
ctmj-148	5	30	found	find	VERB
ctmj-148	5	31	in	in	ADP
ctmj-148	5	32	the	the	DET
ctmj-148	5	33	colorectum	colorectum	NOUN
ctmj-148	5	34	were	be	AUX
ctmj-148	5	35	identified	identify	VERB
ctmj-148	5	36	.	.	PUNCT
ctmj-148	6	1	using	use	VERB
ctmj-148	6	2	databases	database	NOUN
ctmj-148	6	3	and	and	CCONJ
ctmj-148	6	4	the	the	DET
ctmj-148	6	5	literature	literature	NOUN
ctmj-148	6	6	,	,	PUNCT
ctmj-148	6	7	we	we	PRON
ctmj-148	6	8	identified	identify	VERB
ctmj-148	6	9	targets	target	NOUN
ctmj-148	6	10	with	with	ADP
ctmj-148	6	11	the	the	DET
ctmj-148	6	12	potential	potential	NOUN
ctmj-148	6	13	to	to	PART
ctmj-148	6	14	have	have	VERB
ctmj-148	6	15	laxative	laxative	ADJ
ctmj-148	6	16	effects	effect	NOUN
ctmj-148	6	17	.	.	PUNCT
ctmj-148	7	1	then	then	ADV
ctmj-148	7	2	,	,	PUNCT
ctmj-148	7	3	we	we	PRON
ctmj-148	7	4	employed	employ	VERB
ctmj-148	7	5	compounds	compound	NOUN
ctmj-148	7	6	derived	derive	VERB
ctmj-148	7	7	from	from	ADP
ctmj-148	7	8	rhubarb	rhubarb	NOUN
ctmj-148	7	9	in	in	ADP
ctmj-148	7	10	molecular	molecular	ADJ
ctmj-148	7	11	docking	docking	NOUN
ctmj-148	7	12	modelling	modelling	NOUN
ctmj-148	7	13	.	.	PUNCT
ctmj-148	8	1	then	then	ADV
ctmj-148	8	2	,	,	PUNCT
ctmj-148	8	3	using	use	VERB
ctmj-148	8	4	western	western	ADJ
ctmj-148	8	5	blotting	blotting	NOUN
ctmj-148	8	6	,	,	PUNCT
ctmj-148	8	7	we	we	PRON
ctmj-148	8	8	assessed	assess	VERB
ctmj-148	8	9	the	the	DET
ctmj-148	8	10	expression	expression	NOUN
ctmj-148	8	11	of	of	ADP
ctmj-148	8	12	potential	potential	ADJ
ctmj-148	8	13	endogenous	endogenous	ADJ
ctmj-148	8	14	target	target	NOUN
ctmj-148	8	15	molecules	molecule	NOUN
ctmj-148	8	16	that	that	PRON
ctmj-148	8	17	bind	bind	VERB
ctmj-148	8	18	specific	specific	ADJ
ctmj-148	8	19	rhubarb	rhubarb	NOUN
ctmj-148	8	20	components	component	NOUN
ctmj-148	8	21	in	in	ADP
ctmj-148	8	22	rats	rat	NOUN
ctmj-148	8	23	that	that	PRON
ctmj-148	8	24	were	be	AUX
ctmj-148	8	25	either	either	CCONJ
ctmj-148	8	26	given	give	VERB
ctmj-148	8	27	or	or	CCONJ
ctmj-148	8	28	not	not	PART
ctmj-148	8	29	given	give	VERB
ctmj-148	8	30	rhubarb	rhubarb	NOUN
ctmj-148	8	31	for	for	ADP
ctmj-148	8	32	constipation	constipation	NOUN
ctmj-148	8	33	.	.	PUNCT
ctmj-148	9	1	in	in	ADP
ctmj-148	9	2	the	the	DET
ctmj-148	9	3	end	end	NOUN
ctmj-148	9	4	,	,	PUNCT
ctmj-148	9	5	the	the	DET
ctmj-148	9	6	components	component	NOUN
ctmj-148	9	7	of	of	ADP
ctmj-148	9	8	compounds	compound	NOUN
ctmj-148	9	9	that	that	PRON
ctmj-148	9	10	showed	show	VERB
ctmj-148	9	11	promise	promise	NOUN
ctmj-148	9	12	as	as	ADP
ctmj-148	9	13	bioactive	bioactive	PROPN
ctmj-148	9	14	were	be	AUX
ctmj-148	9	15	identified	identify	VERB
ctmj-148	9	16	we	we	PRON
ctmj-148	9	17	found	find	VERB
ctmj-148	9	18	17	17	NUM
ctmj-148	9	19	anthraquinones	anthraquinone	NOUN
ctmj-148	9	20	and	and	CCONJ
ctmj-148	9	21	21	21	NUM
ctmj-148	9	22	anthrones	anthrone	NOUN
ctmj-148	9	23	in	in	ADP
ctmj-148	9	24	the	the	DET
ctmj-148	9	25	rat	rat	NOUN
ctmj-148	9	26	colorectum	colorectum	NOUN
ctmj-148	9	27	,	,	PUNCT
ctmj-148	9	28	which	which	PRON
ctmj-148	9	29	is	be	AUX
ctmj-148	9	30	a	a	DET
ctmj-148	9	31	good	good	ADJ
ctmj-148	9	32	indicator	indicator	NOUN
ctmj-148	9	33	of	of	ADP
ctmj-148	9	34	the	the	DET
ctmj-148	9	35	plant	plant	NOUN
ctmj-148	9	36	's	's	PART
ctmj-148	9	37	medicinal	medicinal	ADJ
ctmj-148	9	38	value	value	NOUN
ctmj-148	9	39	.	.	PUNCT
ctmj-148	10	1	based	base	VERB
ctmj-148	10	2	on	on	ADP
ctmj-148	10	3	g	g	NOUN
ctmj-148	10	4	-	-	PUNCT
ctmj-148	10	5	scoring	scoring	NOUN
ctmj-148	10	6	,	,	PUNCT
ctmj-148	10	7	three	three	NUM
ctmj-148	10	8	proteins	protein	NOUN
ctmj-148	10	9	—	—	PUNCT
ctmj-148	10	10	c	c	NOUN
ctmj-148	10	11	-	-	PUNCT
ctmj-148	10	12	kit	kit	NOUN
ctmj-148	10	13	,	,	PUNCT
ctmj-148	10	14	5	5	NUM
ctmj-148	10	15	-	-	PUNCT
ctmj-148	10	16	hydroxytryptamine	hydroxytryptamine	NOUN
ctmj-148	10	17	receptor	receptor	NOUN
ctmj-148	10	18	4	4	NUM
ctmj-148	10	19	(	(	PUNCT
ctmj-148	10	20	5ht4	5ht4	NUM
ctmj-148	10	21	)	)	PUNCT
ctmj-148	10	22	,	,	PUNCT
ctmj-148	10	23	and	and	CCONJ
ctmj-148	10	24	aquaporin-3	aquaporin-3	PRON
ctmj-148	10	25	(	(	PUNCT
ctmj-148	10	26	aqp3)—may	aqp3)—may	AUX
ctmj-148	10	27	mediate	mediate	VERB
ctmj-148	10	28	the	the	DET
ctmj-148	10	29	laxative	laxative	NOUN
ctmj-148	10	30	action	action	NOUN
ctmj-148	10	31	.	.	PUNCT
ctmj-148	11	1	furthermore	furthermore	ADV
ctmj-148	11	2	,	,	PUNCT
ctmj-148	11	3	ten	ten	NUM
ctmj-148	11	4	components	component	NOUN
ctmj-148	11	5	derived	derive	VERB
ctmj-148	11	6	from	from	ADP
ctmj-148	11	7	rhubarb	rhubarb	NOUN
ctmj-148	11	8	—	—	PUNCT
ctmj-148	11	9	aloe	aloe	NOUN
ctmj-148	11	10	-	-	PUNCT
ctmj-148	11	11	emodin	emodin	PROPN
ctmj-148	11	12	,	,	PUNCT
ctmj-148	11	13	emodin	emodin	PROPN
ctmj-148	11	14	,	,	PUNCT
ctmj-148	11	15	rhein	rhein	NOUN
ctmj-148	11	16	,	,	PUNCT
ctmj-148	11	17	chrysophanol	chrysophanol	NOUN
ctmj-148	11	18	,	,	PUNCT
ctmj-148	11	19	physcion	physcion	NOUN
ctmj-148	11	20	,	,	PUNCT
ctmj-148	11	21	sennoside	sennoside	VERB
ctmj-148	11	22	a	a	PRON
ctmj-148	11	23	,	,	PUNCT
ctmj-148	11	24	sennoside	sennoside	NOUN
ctmj-148	11	25	c	c	NOUN
ctmj-148	11	26	,	,	PUNCT
ctmj-148	11	27	physcionanthrone	physcionanthrone	NOUN
ctmj-148	11	28	,	,	PUNCT
ctmj-148	11	29	aloe	aloe	NOUN
ctmj-148	11	30	-	-	PUNCT
ctmj-148	11	31	emodinanthrone	emodinanthrone	NOUN
ctmj-148	11	32	,	,	PUNCT
ctmj-148	11	33	and	and	CCONJ
ctmj-148	11	34	rheinanthrone	rheinanthrone	NOUN
ctmj-148	11	35	—	—	PUNCT
ctmj-148	11	36	were	be	AUX
ctmj-148	11	37	chosen	choose	VERB
ctmj-148	11	38	as	as	ADP
ctmj-148	11	39	compounds	compound	NOUN
ctmj-148	11	40	with	with	ADP
ctmj-148	11	41	high	high	ADJ
ctmj-148	11	42	probability	probability	NOUN
ctmj-148	11	43	of	of	ADP
ctmj-148	11	44	activity	activity	NOUN
ctmj-148	11	45	due	due	ADP
ctmj-148	11	46	to	to	ADP
ctmj-148	11	47	their	their	PRON
ctmj-148	11	48	strong	strong	ADJ
ctmj-148	11	49	binding	bind	VERB
ctmj-148	11	50	affinity	affinity	NOUN
ctmj-148	11	51	for	for	ADP
ctmj-148	11	52	multiple	multiple	ADJ
ctmj-148	11	53	potential	potential	ADJ
ctmj-148	11	54	targets	target	NOUN
ctmj-148	11	55	.	.	PUNCT
ctmj-148	12	1	it	it	PRON
ctmj-148	12	2	is	be	AUX
ctmj-148	12	3	possible	possible	ADJ
ctmj-148	12	4	that	that	SCONJ
ctmj-148	12	5	the	the	DET
ctmj-148	12	6	laxative	laxative	ADJ
ctmj-148	12	7	action	action	NOUN
ctmj-148	12	8	of	of	ADP
ctmj-148	12	9	rhubarb	rhubarb	NOUN
ctmj-148	12	10	extract	extract	NOUN
ctmj-148	12	11	is	be	AUX
ctmj-148	12	12	mediated	mediate	VERB
ctmj-148	12	13	by	by	ADP
ctmj-148	12	14	the	the	DET
ctmj-148	12	15	fact	fact	NOUN
ctmj-148	12	16	that	that	SCONJ
ctmj-148	12	17	it	it	PRON
ctmj-148	12	18	enhanced	enhance	VERB
ctmj-148	12	19	the	the	DET
ctmj-148	12	20	expression	expression	NOUN
ctmj-148	12	21	of	of	ADP
ctmj-148	12	22	c	c	NOUN
ctmj-148	12	23	-	-	PUNCT
ctmj-148	12	24	kit	kit	NOUN
ctmj-148	12	25	and	and	CCONJ
ctmj-148	12	26	5	5	NUM
ctmj-148	12	27	-	-	PUNCT
ctmj-148	12	28	ht4	ht4	NOUN
ctmj-148	12	29	while	while	SCONJ
ctmj-148	12	30	decreasing	decrease	VERB
ctmj-148	12	31	the	the	DET
ctmj-148	12	32	expression	expression	NOUN
ctmj-148	12	33	of	of	ADP
ctmj-148	12	34	aqp3	aqp3	PROPN
ctmj-148	12	35	in	in	ADP
ctmj-148	12	36	the	the	DET
ctmj-148	12	37	colon	colon	NOUN
ctmj-148	12	38	of	of	ADP
ctmj-148	12	39	rats	rat	NOUN
ctmj-148	12	40	that	that	PRON
ctmj-148	12	41	were	be	AUX
ctmj-148	12	42	constipated	constipate	VERB
ctmj-148	12	43	.	.	PUNCT
ctmj-148	13	1	additionally	additionally	ADV
ctmj-148	13	2	,	,	PUNCT
ctmj-148	13	3	we	we	PRON
ctmj-148	13	4	discovered	discover	VERB
ctmj-148	13	5	that	that	SCONJ
ctmj-148	13	6	a	a	DET
ctmj-148	13	7	single	single	ADJ
ctmj-148	13	8	prototype	prototype	NOUN
ctmj-148	13	9	component	component	NOUN
ctmj-148	13	10	may	may	AUX
ctmj-148	13	11	undergo	undergo	VERB
ctmj-148	13	12	metabolism	metabolism	NOUN
ctmj-148	13	13	into	into	ADP
ctmj-148	13	14	many	many	ADJ
ctmj-148	13	15	active	active	ADJ
ctmj-148	13	16	metabolites	metabolite	NOUN
ctmj-148	13	17	,	,	PUNCT
ctmj-148	13	18	and	and	CCONJ
ctmj-148	13	19	that	that	SCONJ
ctmj-148	13	20	different	different	ADJ
ctmj-148	13	21	molecules	molecule	NOUN
ctmj-148	13	22	from	from	ADP
ctmj-148	13	23	the	the	DET
ctmj-148	13	24	prototype	prototype	NOUN
ctmj-148	13	25	can	can	AUX
ctmj-148	13	26	be	be	AUX
ctmj-148	13	27	combined	combine	VERB
ctmj-148	13	28	to	to	PART
ctmj-148	13	29	form	form	VERB
ctmj-148	13	30	a	a	DET
ctmj-148	13	31	single	single	ADJ
ctmj-148	13	32	active	active	ADJ
ctmj-148	13	33	ingredient	ingredient	NOUN
ctmj-148	13	34	.	.	PUNCT
ctmj-148	14	1	the	the	DET
ctmj-148	14	2	current	current	ADJ
ctmj-148	14	3	research	research	NOUN
ctmj-148	14	4	concludes	conclude	VERB
ctmj-148	14	5	that	that	SCONJ
ctmj-148	14	6	rhubarb	rhubarb	NOUN
ctmj-148	14	7	's	's	PART
ctmj-148	14	8	anthraquinones	anthraquinone	NOUN
ctmj-148	14	9	and	and	CCONJ
ctmj-148	14	10	anthrones	anthrone	NOUN
ctmj-148	14	11	may	may	AUX
ctmj-148	14	12	be	be	AUX
ctmj-148	14	13	metabolised	metabolise	VERB
ctmj-148	14	14	into	into	ADP
ctmj-148	14	15	bioactive	bioactive	ADJ
ctmj-148	14	16	chemicals	chemical	NOUN
ctmj-148	14	17	that	that	PRON
ctmj-148	14	18	enhance	enhance	VERB
ctmj-148	14	19	defecation	defecation	NOUN
ctmj-148	14	20	via	via	ADP
ctmj-148	14	21	c	c	NOUN
ctmj-148	14	22	-	-	PUNCT
ctmj-148	14	23	kit	kit	NOUN
ctmj-148	14	24	,	,	PUNCT
ctmj-148	14	25	5	5	NUM
ctmj-148	14	26	-	-	PUNCT
ctmj-148	14	27	ht4	ht4	ADJ
ctmj-148	14	28	,	,	PUNCT
ctmj-148	14	29	and/or	and/or	CCONJ
ctmj-148	14	30	aqp3	aqp3	PROPN
ctmj-148	14	31	.	.	PUNCT
ctmj-148	14	32	.	.	PUNCT
ctmj-148	15	1	key	key	ADJ
ctmj-148	15	2	words	word	NOUN
ctmj-148	15	3	:	:	PUNCT
ctmj-148	15	4	al7075	al7075	ADJ
ctmj-148	15	5	alloy	alloy	NOUN
ctmj-148	15	6	composite	composite	NOUN
ctmj-148	15	7	,	,	PUNCT
ctmj-148	15	8	e	e	NOUN
ctmj-148	15	9	-	-	NOUN
ctmj-148	15	10	glass	glass	NOUN
ctmj-148	15	11	,	,	PUNCT
ctmj-148	15	12	mmcs	mmcs	ADJ
ctmj-148	15	13	,	,	PUNCT
ctmj-148	15	14	and	and	CCONJ
ctmj-148	15	15	short	short	ADJ
ctmj-148	15	16	e	e	NOUN
ctmj-148	15	17	-	-	NOUN
ctmj-148	15	18	glass	glass	ADJ
ctmj-148	15	19	fibres	fibre	NOUN
ctmj-148	15	20	but	but	CCONJ
ctmj-148	15	21	recent	recent	ADJ
ctmj-148	15	22	research	research	NOUN
ctmj-148	15	23	has	have	AUX
ctmj-148	15	24	found	find	VERB
ctmj-148	15	25	that	that	SCONJ
ctmj-148	15	26	rhubarb	rhubarb	NOUN
ctmj-148	15	27	only	only	ADV
ctmj-148	15	28	contains	contain	VERB
ctmj-148	15	29	around	around	ADP
ctmj-148	15	30	0.08	0.08	NUM
ctmj-148	15	31	%	%	NOUN
ctmj-148	15	32	sennoside	sennoside	NOUN
ctmj-148	15	33	a,7,8	a,7,8	CCONJ
ctmj-148	15	34	which	which	PRON
ctmj-148	15	35	is	be	AUX
ctmj-148	15	36	much	much	ADV
ctmj-148	15	37	too	too	ADV
ctmj-148	15	38	little	little	ADJ
ctmj-148	15	39	to	to	PART
ctmj-148	15	40	explain	explain	VERB
ctmj-148	15	41	the	the	DET
ctmj-148	15	42	plant	plant	NOUN
ctmj-148	15	43	's	's	PART
ctmj-148	15	44	strong	strong	ADJ
ctmj-148	15	45	laxative	laxative	NOUN
ctmj-148	15	46	effects	effect	NOUN
ctmj-148	15	47	.	.	PUNCT
ctmj-148	16	1	in	in	ADP
ctmj-148	16	2	addition	addition	NOUN
ctmj-148	16	3	,	,	PUNCT
ctmj-148	16	4	we	we	PRON
ctmj-148	16	5	found	find	VERB
ctmj-148	16	6	that	that	SCONJ
ctmj-148	16	7	rhubarb	rhubarb	NOUN
ctmj-148	16	8	extract	extract	NOUN
ctmj-148	16	9	had	have	VERB
ctmj-148	16	10	a	a	DET
ctmj-148	16	11	much	much	ADV
ctmj-148	16	12	stronger	strong	ADJ
ctmj-148	16	13	laxative	laxative	ADJ
ctmj-148	16	14	effect	effect	NOUN
ctmj-148	16	15	than	than	ADP
ctmj-148	16	16	the	the	DET
ctmj-148	16	17	same	same	ADJ
ctmj-148	16	18	amount	amount	NOUN
ctmj-148	16	19	of	of	ADP
ctmj-148	16	20	sennoside	sennoside	NOUN
ctmj-148	16	21	a	a	PRON
ctmj-148	16	22	in	in	ADP
ctmj-148	16	23	our	our	PRON
ctmj-148	16	24	early	early	ADJ
ctmj-148	16	25	trial	trial	NOUN
ctmj-148	16	26	.	.	PUNCT
ctmj-148	17	1	according	accord	VERB
ctmj-148	17	2	to	to	ADP
ctmj-148	17	3	their	their	PRON
ctmj-148	17	4	research	research	NOUN
ctmj-148	17	5	,	,	PUNCT
ctmj-148	17	6	the	the	DET
ctmj-148	17	7	exact	exact	ADJ
ctmj-148	17	8	process	process	NOUN
ctmj-148	17	9	by	by	ADP
ctmj-148	17	10	which	which	PRON
ctmj-148	17	11	rhubarb	rhubarb	NOUN
ctmj-148	17	12	produces	produce	VERB
ctmj-148	17	13	its	its	PRON
ctmj-148	17	14	laxative	laxative	NOUN
ctmj-148	17	15	effects	effect	NOUN
ctmj-148	17	16	is	be	AUX
ctmj-148	17	17	still	still	ADV
ctmj-148	17	18	up	up	ADP
ctmj-148	17	19	for	for	ADP
ctmj-148	17	20	debate	debate	NOUN
ctmj-148	17	21	.	.	PUNCT
ctmj-148	18	1	thus	thus	ADV
ctmj-148	18	2	,	,	PUNCT
ctmj-148	18	3	we	we	PRON
ctmj-148	18	4	set	set	VERB
ctmj-148	18	5	out	out	ADP
ctmj-148	18	6	to	to	PART
ctmj-148	18	7	better	well	ADV
ctmj-148	18	8	understand	understand	VERB
ctmj-148	18	9	how	how	SCONJ
ctmj-148	18	10	rhubarb	rhubarb	NOUN
ctmj-148	18	11	's	's	PART
ctmj-148	18	12	laxative	laxative	ADJ
ctmj-148	18	13	action	action	NOUN
ctmj-148	18	14	works	work	VERB
ctmj-148	18	15	so	so	SCONJ
ctmj-148	18	16	that	that	SCONJ
ctmj-148	18	17	its	its	PRON
ctmj-148	18	18	therapeutic	therapeutic	ADJ
ctmj-148	18	19	usage	usage	NOUN
ctmj-148	18	20	may	may	AUX
ctmj-148	18	21	be	be	AUX
ctmj-148	18	22	based	base	VERB
ctmj-148	18	23	on	on	ADP
ctmj-148	18	24	good	good	ADJ
ctmj-148	18	25	theoretical	theoretical	ADJ
ctmj-148	18	26	grounding	grounding	NOUN
ctmj-148	18	27	.	.	PUNCT
ctmj-148	19	1	for	for	ADP
ctmj-148	19	2	clinically	clinically	ADV
ctmj-148	19	3	-	-	PUNCT
ctmj-148	19	4	approved	approve	VERB
ctmj-148	19	5	laxatives	laxative	NOUN
ctmj-148	19	6	,	,	PUNCT
ctmj-148	19	7	the	the	DET
ctmj-148	19	8	two	two	NUM
ctmj-148	19	9	main	main	ADJ
ctmj-148	19	10	ways	way	NOUN
ctmj-148	19	11	they	they	PRON
ctmj-148	19	12	work	work	VERB
ctmj-148	19	13	are	be	AUX
ctmj-148	19	14	by	by	ADP
ctmj-148	19	15	increasing	increase	VERB
ctmj-148	19	16	the	the	DET
ctmj-148	19	17	rate	rate	NOUN
ctmj-148	19	18	of	of	ADP
ctmj-148	19	19	intestinal	intestinal	ADJ
ctmj-148	19	20	motility	motility	NOUN
ctmj-148	19	21	and	and	CCONJ
ctmj-148	19	22	the	the	DET
ctmj-148	19	23	stimulation	stimulation	NOUN
ctmj-148	19	24	of	of	ADP
ctmj-148	19	25	electrolyte	electrolyte	NOUN
ctmj-148	19	26	and	and	CCONJ
ctmj-148	19	27	water	water	NOUN
ctmj-148	19	28	secretion	secretion	NOUN
ctmj-148	19	29	.	.	PUNCT
ctmj-148	20	1	one	one	NUM
ctmj-148	20	2	popular	popular	ADJ
ctmj-148	20	3	medicine	medicine	NOUN
ctmj-148	20	4	,	,	PUNCT
ctmj-148	20	5	prucalopride	prucalopride	NOUN
ctmj-148	20	6	,	,	PUNCT
ctmj-148	20	7	increases	increase	VERB
ctmj-148	20	8	colonic	colonic	ADJ
ctmj-148	20	9	motility	motility	NOUN
ctmj-148	20	10	by	by	ADP
ctmj-148	20	11	stimulating	stimulate	VERB
ctmj-148	20	12	neuronal	neuronal	ADJ
ctmj-148	20	13	5hydroxytryptamine	5hydroxytryptamine	NUM
ctmj-148	20	14	receptor	receptor	NOUN
ctmj-148	20	15	4	4	NUM
ctmj-148	20	16	(	(	PUNCT
ctmj-148	20	17	5	5	NUM
ctmj-148	20	18	-	-	PUNCT
ctmj-148	20	19	ht4	ht4	NOUN
ctmj-148	20	20	)	)	PUNCT
ctmj-148	20	21	,	,	PUNCT
ctmj-148	20	22	which	which	PRON
ctmj-148	20	23	in	in	ADP
ctmj-148	20	24	turn	turn	NOUN
ctmj-148	20	25	increases	increase	VERB
ctmj-148	20	26	the	the	DET
ctmj-148	20	27	contraction	contraction	NOUN
ctmj-148	20	28	of	of	ADP
ctmj-148	20	29	the	the	DET
ctmj-148	20	30	muscles	muscle	NOUN
ctmj-148	20	31	lining	line	VERB
ctmj-148	20	32	the	the	DET
ctmj-148	20	33	intestines.11th	intestines.11th	NOUN
ctmj-148	20	34	to	to	ADP
ctmj-148	20	35	9th	9th	NOUN
ctmj-148	20	36	as	as	ADP
ctmj-148	20	37	an	an	DET
ctmj-148	20	38	example	example	NOUN
ctmj-148	20	39	,	,	PUNCT
ctmj-148	20	40	osmotic	osmotic	ADJ
ctmj-148	20	41	laxatives	laxative	NOUN
ctmj-148	20	42	like	like	ADP
ctmj-148	20	43	magnesium	magnesium	NOUN
ctmj-148	20	44	sulphate	sulphate	NOUN
ctmj-148	20	45	control	control	NOUN
ctmj-148	20	46	the	the	DET
ctmj-148	20	47	expression	expression	NOUN
ctmj-148	20	48	of	of	ADP
ctmj-148	20	49	aquaporin-3	aquaporin-3	PRON
ctmj-148	20	50	(	(	PUNCT
ctmj-148	20	51	aqp3	aqp3	PROPN
ctmj-148	20	52	)	)	PUNCT
ctmj-148	20	53	in	in	ADP
ctmj-148	20	54	colonic	colonic	ADJ
ctmj-148	20	55	epithelial	epithelial	ADJ
ctmj-148	20	56	cells	cell	NOUN
ctmj-148	20	57	,	,	PUNCT
ctmj-148	20	58	which	which	PRON
ctmj-148	20	59	leads	lead	VERB
ctmj-148	20	60	to	to	ADP
ctmj-148	20	61	water	water	NOUN
ctmj-148	20	62	buildup	buildup	NOUN
ctmj-148	20	63	in	in	ADP
ctmj-148	20	64	the	the	DET
ctmj-148	20	65	intestinal	intestinal	ADJ
ctmj-148	20	66	lumen	luman	NOUN
ctmj-148	20	67	and	and	CCONJ
ctmj-148	20	68	promotes	promote	VERB
ctmj-148	20	69	defecation.12	defecation.12	NOUN
ctmj-148	20	70	,	,	PUNCT
ctmj-148	20	71	13	13	NUM
ctmj-148	20	72	since	since	SCONJ
ctmj-148	20	73	these	these	DET
ctmj-148	20	74	laxatives	laxative	NOUN
ctmj-148	20	75	act	act	VERB
ctmj-148	20	76	on	on	ADP
ctmj-148	20	77	specific	specific	ADJ
ctmj-148	20	78	molecular	molecular	ADJ
ctmj-148	20	79	targets	target	NOUN
ctmj-148	20	80	in	in	ADP
ctmj-148	20	81	the	the	DET
ctmj-148	20	82	colon	colon	NOUN
ctmj-148	20	83	,	,	PUNCT
ctmj-148	20	84	it	it	PRON
ctmj-148	20	85	is	be	AUX
ctmj-148	20	86	vital	vital	ADJ
ctmj-148	20	87	to	to	PART
ctmj-148	20	88	identify	identify	VERB
ctmj-148	20	89	these	these	DET
ctmj-148	20	90	targets	target	NOUN
ctmj-148	20	91	and	and	CCONJ
ctmj-148	20	92	the	the	DET
ctmj-148	20	93	specific	specific	ADJ
ctmj-148	20	94	rhubarb	rhubarb	NOUN
ctmj-148	20	95	components	component	NOUN
ctmj-148	20	96	involved	involve	VERB
ctmj-148	20	97	in	in	ADP
ctmj-148	20	98	order	order	NOUN
ctmj-148	20	99	to	to	PART
ctmj-148	20	100	deduce	deduce	VERB
ctmj-148	20	101	how	how	SCONJ
ctmj-148	20	102	rhubarb	rhubarb	NOUN
ctmj-148	20	103	exerts	exert	VERB
ctmj-148	20	104	its	its	PRON
ctmj-148	20	105	laxative	laxative	NOUN
ctmj-148	20	106	effects	effect	NOUN
ctmj-148	20	107	.	.	PUNCT
ctmj-148	21	1	applying	apply	VERB
ctmj-148	21	2	the	the	DET
ctmj-148	21	3	notion	notion	NOUN
ctmj-148	21	4	of	of	ADP
ctmj-148	21	5	induced	induced	ADJ
ctmj-148	21	6	fit	fit	NOUN
ctmj-148	21	7	and	and	CCONJ
ctmj-148	21	8	the	the	DET
ctmj-148	21	9	lockand	lockand	NOUN
ctmj-148	21	10	-	-	PUNCT
ctmj-148	21	11	key	key	NOUN
ctmj-148	21	12	principle,14	principle,14	NOUN
ctmj-148	21	13	one	one	NUM
ctmj-148	21	14	efficient	efficient	ADJ
ctmj-148	21	15	method	method	NOUN
ctmj-148	21	16	for	for	ADP
ctmj-148	21	17	identifying	identify	VERB
ctmj-148	21	18	therapeutic	therapeutic	ADJ
ctmj-148	21	19	targets	target	NOUN
ctmj-148	21	20	and	and	CCONJ
ctmj-148	21	21	quickly	quickly	ADV
ctmj-148	21	22	screening	screen	VERB
ctmj-148	21	23	possible	possible	ADJ
ctmj-148	21	24	active	active	ADJ
ctmj-148	21	25	molecules	molecule	NOUN
ctmj-148	21	26	is	be	AUX
ctmj-148	21	27	molecular	molecular	ADJ
ctmj-148	21	28	docking	docking	NOUN
ctmj-148	21	29	modelling	modelling	NOUN
ctmj-148	21	30	.	.	PUNCT
ctmj-148	22	1	the	the	DET
ctmj-148	22	2	sole	sole	ADJ
ctmj-148	22	3	applications	application	NOUN
ctmj-148	22	4	for	for	ADP
ctmj-148	22	5	this	this	PRON
ctmj-148	22	6	are	be	AUX
ctmj-148	22	7	the	the	DET
ctmj-148	22	8	screening	screening	NOUN
ctmj-148	22	9	of	of	ADP
ctmj-148	22	10	bioactive	bioactive	ADJ
ctmj-148	22	11	compounds	compound	NOUN
ctmj-148	22	12	and	and	CCONJ
ctmj-148	22	13	potential	potential	ADJ
ctmj-148	22	14	targets	target	NOUN
ctmj-148	22	15	.	.	PUNCT
ctmj-148	23	1	we	we	PRON
ctmj-148	23	2	wanted	want	VERB
ctmj-148	23	3	to	to	PART
ctmj-148	23	4	conduct	conduct	VERB
ctmj-148	23	5	molecular	molecular	ADJ
ctmj-148	23	6	docking	docking	NOUN
ctmj-148	23	7	analysis	analysis	NOUN
ctmj-148	23	8	utilising	utilise	VERB
ctmj-148	23	9	active	active	ADJ
ctmj-148	23	10	,	,	PUNCT
ctmj-148	23	11	biotransformed	biotransformed	ADJ
ctmj-148	23	12	rhubarb	rhubarb	NOUN
ctmj-148	23	13	derivatives	derivative	NOUN
ctmj-148	23	14	and	and	CCONJ
ctmj-148	23	15	endogenous	endogenous	ADJ
ctmj-148	23	16	molecules	molecule	NOUN
ctmj-148	23	17	that	that	PRON
ctmj-148	23	18	could	could	AUX
ctmj-148	23	19	mediate	mediate	VERB
ctmj-148	23	20	the	the	DET
ctmj-148	23	21	laxative	laxative	ADJ
ctmj-148	23	22	action	action	NOUN
ctmj-148	23	23	to	to	PART
ctmj-148	23	24	discover	discover	VERB
ctmj-148	23	25	the	the	DET
ctmj-148	23	26	active	active	ADJ
ctmj-148	23	27	compounds	compound	NOUN
ctmj-148	23	28	in	in	ADP
ctmj-148	23	29	the	the	DET
ctmj-148	23	30	col	col	NOUN
ctmj-148	23	31	-	-	NOUN
ctmj-148	23	32	orectum	orectum	NOUN
ctmj-148	23	33	.	.	PUNCT
ctmj-148	24	1	our	our	PRON
ctmj-148	24	2	goal	goal	NOUN
ctmj-148	24	3	was	be	AUX
ctmj-148	24	4	to	to	PART
ctmj-148	24	5	increase	increase	VERB
ctmj-148	24	6	the	the	DET
ctmj-148	24	7	data	datum	NOUN
ctmj-148	24	8	's	's	PART
ctmj-148	24	9	biological	biological	ADJ
ctmj-148	24	10	relevance	relevance	NOUN
ctmj-148	24	11	.	.	PUNCT
ctmj-148	25	1	we	we	PRON
ctmj-148	25	2	used	use	VERB
ctmj-148	25	3	the	the	PRON
ctmj-148	25	4	in	in	ADP
ctmj-148	25	5	vivo	vivo	ADJ
ctmj-148	25	6	metabolic	metabolic	NOUN
ctmj-148	25	7	understanding	understanding	NOUN
ctmj-148	25	8	of	of	ADP
ctmj-148	25	9	the	the	DET
ctmj-148	25	10	chemicals	chemical	NOUN
ctmj-148	25	11	in	in	ADP
ctmj-148	25	12	rhubarb	rhubarb	NOUN
ctmj-148	25	13	to	to	PART
ctmj-148	25	14	discover	discover	VERB
ctmj-148	25	15	the	the	DET
ctmj-148	25	16	appropriate	appropriate	ADJ
ctmj-148	25	17	bioactive	bioactive	ADJ
ctmj-148	25	18	derivatives	derivative	NOUN
ctmj-148	25	19	in	in	ADP
ctmj-148	25	20	the	the	DET
ctmj-148	25	21	prototype	prototype	NOUN
ctmj-148	25	22	by	by	ADP
ctmj-148	25	23	tracing	trace	VERB
ctmj-148	25	24	the	the	DET
ctmj-148	25	25	biotransformation	biotransformation	NOUN
ctmj-148	25	26	products	product	NOUN
ctmj-148	25	27	back	back	ADV
ctmj-148	25	28	to	to	ADP
ctmj-148	25	29	the	the	DET
ctmj-148	25	30	original	original	ADJ
ctmj-148	25	31	plant.15	plant.15	NOUN
ctmj-148	25	32	establishing	establish	VERB
ctmj-148	25	33	suitable	suitable	ADJ
ctmj-148	25	34	quality	quality	NOUN
ctmj-148	25	35	control	control	NOUN
ctmj-148	25	36	procedures	procedure	NOUN
ctmj-148	25	37	and	and	CCONJ
ctmj-148	25	38	providing	provide	VERB
ctmj-148	25	39	a	a	DET
ctmj-148	25	40	reference	reference	NOUN
ctmj-148	25	41	for	for	ADP
ctmj-148	25	42	the	the	DET
ctmj-148	25	43	use	use	NOUN
ctmj-148	25	44	of	of	ADP
ctmj-148	25	45	rhubarb	rhubarb	NOUN
ctmj-148	25	46	derivatives	derivative	NOUN
ctmj-148	25	47	in	in	ADP
ctmj-148	25	48	the	the	DET
ctmj-148	25	49	clinic	clinic	NOUN
ctmj-148	25	50	would	would	AUX
ctmj-148	25	51	be	be	AUX
ctmj-148	25	52	greatly	greatly	ADV
ctmj-148	25	53	aided	aid	VERB
ctmj-148	25	54	by	by	ADP
ctmj-148	25	55	the	the	DET
ctmj-148	25	56	identification	identification	NOUN
ctmj-148	25	57	of	of	ADP
ctmj-148	25	58	bioactive	bioactive	ADJ
ctmj-148	25	59	components	component	NOUN
ctmj-148	25	60	in	in	ADP
ctmj-148	25	61	rhubarb	rhubarb	NOUN
ctmj-148	25	62	.	.	PUNCT
ctmj-148	26	1	our	our	PRON
ctmj-148	26	2	goal	goal	NOUN
ctmj-148	26	3	here	here	ADV
ctmj-148	26	4	was	be	AUX
ctmj-148	26	5	to	to	PART
ctmj-148	26	6	find	find	VERB
ctmj-148	26	7	endogenous	endogenous	ADJ
ctmj-148	26	8	molecular	molecular	ADJ
ctmj-148	26	9	targets	target	NOUN
ctmj-148	26	10	that	that	PRON
ctmj-148	26	11	might	might	AUX
ctmj-148	26	12	modulate	modulate	VERB
ctmj-148	26	13	the	the	DET
ctmj-148	26	14	actions	action	NOUN
ctmj-148	26	15	of	of	ADP
ctmj-148	26	16	rhubarb	rhubarb	ADJ
ctmj-148	26	17	derivatives	derivative	NOUN
ctmj-148	26	18	that	that	PRON
ctmj-148	26	19	could	could	AUX
ctmj-148	26	20	have	have	VERB
ctmj-148	26	21	cumulative	cumulative	ADJ
ctmj-148	26	22	or	or	CCONJ
ctmj-148	26	23	synergistic	synergistic	ADJ
ctmj-148	26	24	effects	effect	NOUN
ctmj-148	26	25	to	to	PART
ctmj-148	26	26	stimulate	stimulate	VERB
ctmj-148	26	27	defecation	defecation	NOUN
ctmj-148	26	28	.	.	PUNCT
ctmj-148	27	1	the	the	DET
ctmj-148	27	2	first	first	ADJ
ctmj-148	27	3	step	step	NOUN
ctmj-148	27	4	was	be	AUX
ctmj-148	27	5	to	to	PART
ctmj-148	27	6	use	use	VERB
ctmj-148	27	7	high	high	ADJ
ctmj-148	27	8	-	-	PUNCT
ctmj-148	27	9	performance	performance	NOUN
ctmj-148	27	10	liquid	liquid	ADJ
ctmj-148	27	11	chromatography	chromatography	NOUN
ctmj-148	27	12	in	in	ADP
ctmj-148	27	13	conjunction	conjunction	NOUN
ctmj-148	27	14	with	with	ADP
ctmj-148	27	15	linear	linear	ADJ
ctmj-148	27	16	ion	ion	NOUN
ctmj-148	27	17	-	-	PUNCT
ctmj-148	27	18	trap	trap	NOUN
ctmj-148	27	19	quadrupole	quadrupole	NOUN
ctmj-148	27	20	orbitrap	orbitrap	ADJ
ctmj-148	27	21	high	high	ADJ
ctmj-148	27	22	-	-	PUNCT
ctmj-148	27	23	resolution	resolution	NOUN
ctmj-148	27	24	mass	mass	ADJ
ctmj-148	27	25	spectrometry	spectrometry	NOUN
ctmj-148	27	26	to	to	PART
ctmj-148	27	27	identify	identify	VERB
ctmj-148	27	28	the	the	DET
ctmj-148	27	29	rhubarb	rhubarb	ADJ
ctmj-148	27	30	derivatives	derivative	NOUN
ctmj-148	27	31	that	that	PRON
ctmj-148	27	32	were	be	AUX
ctmj-148	27	33	found	find	VERB
ctmj-148	27	34	in	in	ADP
ctmj-148	27	35	the	the	DET
ctmj-148	27	36	colorectum	colorectum	NOUN
ctmj-148	27	37	.	.	PUNCT
ctmj-148	28	1	the	the	DET
ctmj-148	28	2	next	next	ADJ
ctmj-148	28	3	step	step	NOUN
ctmj-148	28	4	was	be	AUX
ctmj-148	28	5	to	to	PART
ctmj-148	28	6	find	find	VERB
ctmj-148	28	7	possible	possible	ADJ
ctmj-148	28	8	molecular	molecular	ADJ
ctmj-148	28	9	targets	target	NOUN
ctmj-148	28	10	by	by	ADP
ctmj-148	28	11	searching	search	VERB
ctmj-148	28	12	the	the	DET
ctmj-148	28	13	literature	literature	NOUN
ctmj-148	28	14	,	,	PUNCT
ctmj-148	28	15	the	the	DET
ctmj-148	28	16	drug	drug	NOUN
ctmj-148	28	17	bank	bank	PROPN
ctmj-148	28	18	database	database	NOUN
ctmj-148	28	19	(	(	PUNCT
ctmj-148	28	20	dbd	dbd	NOUN
ctmj-148	28	21	)	)	PUNCT
ctmj-148	28	22	,	,	PUNCT
ctmj-148	28	23	and	and	CCONJ
ctmj-148	28	24	the	the	DET
ctmj-148	28	25	therapeutic	therapeutic	ADJ
ctmj-148	28	26	target	target	NOUN
ctmj-148	28	27	database	database	NOUN
ctmj-148	28	28	(	(	PUNCT
ctmj-148	28	29	ttd	ttd	NOUN
ctmj-148	28	30	)	)	PUNCT
ctmj-148	28	31	.	.	PUNCT
ctmj-148	29	1	as	as	ADP
ctmj-148	29	2	a	a	DET
ctmj-148	29	3	further	further	ADJ
ctmj-148	29	4	step	step	NOUN
ctmj-148	29	5	,	,	PUNCT
ctmj-148	29	6	we	we	PRON
ctmj-148	29	7	ran	run	VERB
ctmj-148	29	8	molecular	molecular	ADJ
ctmj-148	29	9	docking	docking	NOUN
ctmj-148	29	10	simulations	simulation	NOUN
ctmj-148	29	11	with	with	ADP
ctmj-148	29	12	all	all	PRON
ctmj-148	29	13	of	of	ADP
ctmj-148	29	14	the	the	DET
ctmj-148	29	15	rhubarb	rhubarb	NOUN
ctmj-148	29	16	derivatives	derivative	NOUN
ctmj-148	29	17	and	and	CCONJ
ctmj-148	29	18	all	all	PRON
ctmj-148	29	19	of	of	ADP
ctmj-148	29	20	the	the	DET
ctmj-148	29	21	possible	possible	ADJ
ctmj-148	29	22	molecular	molecular	ADJ
ctmj-148	29	23	targets	target	NOUN
ctmj-148	29	24	to	to	PART
ctmj-148	29	25	find	find	VERB
ctmj-148	29	26	binding	bind	VERB
ctmj-148	29	27	partners	partner	NOUN
ctmj-148	29	28	.	.	PUNCT
ctmj-148	30	1	next	next	ADV
ctmj-148	30	2	,	,	PUNCT
ctmj-148	30	3	we	we	PRON
ctmj-148	30	4	performed	perform	VERB
ctmj-148	30	5	protein	protein	NOUN
ctmj-148	30	6	analysis	analysis	NOUN
ctmj-148	30	7	of	of	ADP
ctmj-148	30	8	treated	treat	VERB
ctmj-148	30	9	rats	rat	NOUN
ctmj-148	30	10	'	'	PART
ctmj-148	30	11	colonic	colonic	ADJ
ctmj-148	30	12	lysates	lysate	NOUN
ctmj-148	30	13	to	to	PART
ctmj-148	30	14	find	find	VERB
ctmj-148	30	15	out	out	ADP
ctmj-148	30	16	whether	whether	SCONJ
ctmj-148	30	17	the	the	DET
ctmj-148	30	18	molecular	molecular	ADJ
ctmj-148	30	19	targets	target	NOUN
ctmj-148	30	20	that	that	PRON
ctmj-148	30	21	were	be	AUX
ctmj-148	30	22	identified	identify	VERB
ctmj-148	30	23	in	in	ADP
ctmj-148	30	24	silico	silico	NOUN
ctmj-148	30	25	were	be	AUX
ctmj-148	30	26	controlled	control	VERB
ctmj-148	30	27	in	in	ADP
ctmj-148	30	28	vivo	vivo	NOUN
ctmj-148	30	29	.	.	PUNCT
ctmj-148	31	1	lastly	lastly	ADV
ctmj-148	31	2	,	,	PUNCT
ctmj-148	31	3	the	the	DET
ctmj-148	31	4	active	active	ADJ
ctmj-148	31	5	elements	element	NOUN
ctmj-148	31	6	in	in	ADP
ctmj-148	31	7	colorectum	colorectum	NOUN
ctmj-148	31	8	were	be	AUX
ctmj-148	31	9	identified	identify	VERB
ctmj-148	31	10	by	by	ADP
ctmj-148	31	11	tracing	trace	VERB
ctmj-148	31	12	them	they	PRON
ctmj-148	31	13	back	back	ADV
ctmj-148	31	14	to	to	ADP
ctmj-148	31	15	components	component	NOUN
ctmj-148	31	16	of	of	ADP
ctmj-148	31	17	rhubarb	rhubarb	NOUN
ctmj-148	31	18	,	,	PUNCT
ctmj-148	31	19	utilising	utilise	VERB
ctmj-148	31	20	knowledge	knowledge	NOUN
ctmj-148	31	21	of	of	ADP
ctmj-148	31	22	the	the	DET
ctmj-148	31	23	metabolism	metabolism	NOUN
ctmj-148	31	24	of	of	ADP
ctmj-148	31	25	related	related	ADJ
ctmj-148	31	26	chemicals	chemical	NOUN
ctmj-148	31	27	.	.	PUNCT
ctmj-148	32	1	this	this	DET
ctmj-148	32	2	study	study	NOUN
ctmj-148	32	3	technique	technique	NOUN
ctmj-148	32	4	has	have	AUX
ctmj-148	32	5	greatly	greatly	ADV
ctmj-148	32	6	contributed	contribute	VERB
ctmj-148	32	7	to	to	ADP
ctmj-148	32	8	our	our	PRON
ctmj-148	32	9	understanding	understanding	NOUN
ctmj-148	32	10	of	of	ADP
ctmj-148	32	11	the	the	DET
ctmj-148	32	12	laxative	laxative	NOUN
ctmj-148	32	13	mechanism	mechanism	NOUN
ctmj-148	32	14	of	of	ADP
ctmj-148	32	15	rhubarb	rhubarb	NOUN
ctmj-148	32	16	by	by	ADP
ctmj-148	32	17	identifying	identify	VERB
ctmj-148	32	18	essential	essential	ADJ
ctmj-148	32	19	components	component	NOUN
ctmj-148	32	20	responsible	responsible	ADJ
ctmj-148	32	21	for	for	ADP
ctmj-148	32	22	its	its	PRON
ctmj-148	32	23	therapeutic	therapeutic	ADJ
ctmj-148	32	24	actions	action	NOUN
ctmj-148	32	25	and	and	CCONJ
ctmj-148	32	26	their	their	PRON
ctmj-148	32	27	prospective	prospective	ADJ
ctmj-148	32	28	molecular	molecular	ADJ
ctmj-148	32	29	targets	target	NOUN
ctmj-148	32	30	.	.	PUNCT
ctmj-148	33	1	because	because	SCONJ
ctmj-148	33	2	herbal	herbal	ADJ
ctmj-148	33	3	medicines	medicine	NOUN
ctmj-148	33	4	include	include	VERB
ctmj-148	33	5	several	several	ADJ
ctmj-148	33	6	bioactive	bioactive	ADJ
ctmj-148	33	7	components	component	NOUN
ctmj-148	33	8	with	with	ADP
ctmj-148	33	9	various	various	ADJ
ctmj-148	33	10	potential	potential	ADJ
ctmj-148	33	11	mammalian	mammalian	ADJ
ctmj-148	33	12	molecular	molecular	ADJ
ctmj-148	33	13	targets	target	NOUN
ctmj-148	33	14	,	,	PUNCT
ctmj-148	33	15	this	this	DET
ctmj-148	33	16	technique	technique	NOUN
ctmj-148	33	17	might	might	AUX
ctmj-148	33	18	be	be	AUX
ctmj-148	33	19	valuable	valuable	ADJ
ctmj-148	33	20	in	in	ADP
ctmj-148	33	21	future	future	ADJ
ctmj-148	33	22	mechanistic	mechanistic	ADJ
ctmj-148	33	23	investigations	investigation	NOUN
ctmj-148	33	24	of	of	ADP
ctmj-148	33	25	these	these	DET
ctmj-148	33	26	treatments	treatment	NOUN
ctmj-148	33	27	.	.	PUNCT
ctmj-148	34	1	materials	material	NOUN
ctmj-148	34	2	and	and	CCONJ
ctmj-148	34	3	methods	method	NOUN
ctmj-148	34	4	ethical	ethical	ADJ
ctmj-148	34	5	approval	approval	NOUN
ctmj-148	34	6	the	the	DET
ctmj-148	34	7	study	study	NOUN
ctmj-148	34	8	protocols	protocol	NOUN
ctmj-148	34	9	were	be	AUX
ctmj-148	34	10	approved	approve	VERB
ctmj-148	34	11	by	by	ADP
ctmj-148	34	12	the	the	DET
ctmj-148	34	13	ethics	ethic	NOUN
ctmj-148	34	14	committee	committee	PROPN
ctmj-148	34	15	of	of	ADP
ctmj-148	34	16	beijing	beijing	PROPN
ctmj-148	34	17	university	university	PROPN
ctmj-148	34	18	of	of	ADP
ctmj-148	34	19	chinese	chinese	ADJ
ctmj-148	34	20	medicine	medicine	NOUN
ctmj-148	34	21	(	(	PUNCT
ctmj-148	34	22	bucm4	bucm4	NOUN
ctmj-148	34	23	-	-	PUNCT
ctmj-148	34	24	20171026011026	20171026011026	NUM
ctmj-148	34	25	;	;	PUNCT
ctmj-148	34	26	beijing	beijing	PROPN
ctmj-148	34	27	,	,	PUNCT
ctmj-148	34	28	china	china	PROPN
ctmj-148	34	29	)	)	PUNCT
ctmj-148	34	30	.	.	PUNCT
ctmj-148	35	1	chemicals	chemical	NOUN
ctmj-148	35	2	and	and	CCONJ
ctmj-148	35	3	reagents	reagent	NOUN
ctmj-148	35	4	rhubarb	rhubarb	NOUN
ctmj-148	35	5	was	be	AUX
ctmj-148	35	6	provided	provide	VERB
ctmj-148	35	7	by	by	ADP
ctmj-148	35	8	the	the	DET
ctmj-148	35	9	modern	modern	ADJ
ctmj-148	35	10	research	research	NOUN
ctmj-148	35	11	center	center	NOUN
ctmj-148	35	12	of	of	ADP
ctmj-148	35	13	traditional	traditional	ADJ
ctmj-148	35	14	chinese	chinese	ADJ
ctmj-148	35	15	medicine	medicine	NOUN
ctmj-148	35	16	,	,	PUNCT
ctmj-148	35	17	peking	peking	PROPN
ctmj-148	35	18	university	university	PROPN
ctmj-148	35	19	(	(	PUNCT
ctmj-148	35	20	beijing	beijing	PROPN
ctmj-148	35	21	,	,	PUNCT
ctmj-148	35	22	china	china	PROPN
ctmj-148	35	23	)	)	PUNCT
ctmj-148	35	24	.	.	PUNCT
ctmj-148	36	1	loperamide	loperamide	PROPN
ctmj-148	36	2	was	be	AUX
ctmj-148	36	3	purchased	purchase	VERB
ctmj-148	36	4	from	from	ADP
ctmj-148	36	5	xian	xian	PROPN
ctmj-148	36	6	janssen	janssen	PROPN
ctmj-148	36	7	pharmaceutical	pharmaceutical	PROPN
ctmj-148	36	8	(	(	PUNCT
ctmj-148	36	9	xi’an	xi’an	PROPN
ctmj-148	36	10	,	,	PUNCT
ctmj-148	36	11	china	china	PROPN
ctmj-148	36	12	)	)	PUNCT
ctmj-148	36	13	.	.	PUNCT
ctmj-148	37	1	standard	standard	ADJ
ctmj-148	37	2	substances	substance	NOUN
ctmj-148	37	3	,	,	PUNCT
ctmj-148	37	4	including	include	VERB
ctmj-148	37	5	emodin	emodin	VERB
ctmj-148	37	6	(	(	PUNCT
ctmj-148	37	7	lot	lot	NOUN
ctmj-148	37	8	code	code	NOUN
ctmj-148	37	9	:	:	PUNCT
ctmj-148	37	10	110756	110756	NUM
ctmj-148	37	11	-	-	SYM
ctmj-148	37	12	201512	201512	NUM
ctmj-148	37	13	,	,	PUNCT
ctmj-148	37	14	98.7	98.7	NUM
ctmj-148	37	15	%	%	NOUN
ctmj-148	37	16	)	)	PUNCT
ctmj-148	37	17	,	,	PUNCT
ctmj-148	37	18	rhein	rhein	NOUN
ctmj-148	37	19	(	(	PUNCT
ctmj-148	37	20	lot	lot	NOUN
ctmj-148	37	21	code	code	NOUN
ctmj-148	37	22	:	:	PUNCT
ctmj-148	37	23	110757	110757	NUM
ctmj-148	37	24	-	-	SYM
ctmj-148	37	25	201607	201607	NUM
ctmj-148	37	26	,	,	PUNCT
ctmj-148	37	27	99.3	99.3	NUM
ctmj-148	37	28	%	%	NOUN
ctmj-148	37	29	)	)	PUNCT
ctmj-148	37	30	,	,	PUNCT
ctmj-148	37	31	physcion	physcion	NOUN
ctmj-148	37	32	(	(	PUNCT
ctmj-148	37	33	lot	lot	NOUN
ctmj-148	37	34	code	code	NOUN
ctmj-148	37	35	:	:	PUNCT
ctmj-148	37	36	110758	110758	NUM
ctmj-148	37	37	-	-	SYM
ctmj-148	37	38	201616	201616	NUM
ctmj-148	37	39	,	,	PUNCT
ctmj-148	37	40	99.0	99.0	NUM
ctmj-148	37	41	%	%	NOUN
ctmj-148	37	42	)	)	PUNCT
ctmj-148	37	43	,	,	PUNCT
ctmj-148	37	44	aloe	aloe	PROPN
ctmj-148	37	45	-	-	PUNCT
ctmj-148	37	46	emodin	emodin	VERB
ctmj-148	37	47	(	(	PUNCT
ctmj-148	37	48	lot	lot	PROPN
ctmj-148	37	49	code	code	NOUN
ctmj-148	37	50	:	:	PUNCT
ctmj-148	37	51	110795	110795	NUM
ctmj-148	37	52	-	-	SYM
ctmj-148	37	53	201710	201710	NUM
ctmj-148	37	54	,	,	PUNCT
ctmj-148	37	55	98.3	98.3	NUM
ctmj-148	37	56	%	%	NOUN
ctmj-148	37	57	)	)	PUNCT
ctmj-148	37	58	,	,	PUNCT
ctmj-148	37	59	chrysophanol	chrysophanol	NOUN
ctmj-148	37	60	(	(	PUNCT
ctmj-148	37	61	lot	lot	NOUN
ctmj-148	37	62	code	code	NOUN
ctmj-148	37	63	:	:	PUNCT
ctmj-148	37	64	110796	110796	NUM
ctmj-148	37	65	-	-	SYM
ctmj-148	37	66	201721	201721	NUM
ctmj-148	37	67	,	,	PUNCT
ctmj-148	37	68	99.2	99.2	NUM
ctmj-148	37	69	%	%	NOUN
ctmj-148	37	70	)	)	PUNCT
ctmj-148	37	71	,	,	PUNCT
ctmj-148	37	72	sennoside	sennoside	VERB
ctmj-148	37	73	a	a	DET
ctmj-148	37	74	(	(	PUNCT
ctmj-148	37	75	lot	lot	NOUN
ctmj-148	37	76	code	code	NOUN
ctmj-148	37	77	:	:	PUNCT
ctmj-148	37	78	110824	110824	NUM
ctmj-148	37	79	-	-	SYM
ctmj-148	37	80	201702	201702	NUM
ctmj-148	37	81	,	,	PUNCT
ctmj-148	37	82	95.2	95.2	NUM
ctmj-148	37	83	%	%	NOUN
ctmj-148	37	84	)	)	PUNCT
ctmj-148	37	85	,	,	PUNCT
ctmj-148	37	86	and	and	CCONJ
ctmj-148	37	87	sennoside	sennoside	NOUN
ctmj-148	37	88	b	b	PROPN
ctmj-148	37	89	(	(	PUNCT
ctmj-148	37	90	lot	lot	PROPN
ctmj-148	37	91	code	code	NOUN
ctmj-148	37	92	:	:	PUNCT
ctmj-148	37	93	110825	110825	NUM
ctmj-148	37	94	-	-	SYM
ctmj-148	37	95	201603	201603	NUM
ctmj-148	37	96	,	,	PUNCT
ctmj-148	37	97	95.0	95.0	NUM
ctmj-148	37	98	%	%	NOUN
ctmj-148	37	99	)	)	PUNCT
ctmj-148	37	100	were	be	AUX
ctmj-148	37	101	all	all	PRON
ctmj-148	37	102	obtained	obtain	VERB
ctmj-148	37	103	from	from	ADP
ctmj-148	37	104	the	the	DET
ctmj-148	37	105	national	national	PROPN
ctmj-148	37	106	institutes	institutes	PROPN
ctmj-148	37	107	for	for	ADP
ctmj-148	37	108	food	food	NOUN
ctmj-148	37	109	and	and	CCONJ
ctmj-148	37	110	drug	drug	NOUN
ctmj-148	37	111	control	control	NOUN
ctmj-148	37	112	(	(	PUNCT
ctmj-148	37	113	beijing	beijing	PROPN
ctmj-148	37	114	,	,	PUNCT
ctmj-148	37	115	china	china	PROPN
ctmj-148	37	116	)	)	PUNCT
ctmj-148	37	117	.	.	PUNCT
ctmj-148	38	1	standard	standard	ADJ
ctmj-148	38	2	substances	substance	NOUN
ctmj-148	38	3	,	,	PUNCT
ctmj-148	38	4	including	include	VERB
ctmj-148	38	5	emodin-8	emodin-8	NUM
ctmj-148	38	6	-	-	PUNCT
ctmj-148	38	7	o	o	NOUN
ctmj-148	38	8	-	-	PUNCT
ctmj-148	38	9	b	b	NOUN
ctmj-148	38	10	-	-	PUNCT
ctmj-148	38	11	d	d	NOUN
ctmj-148	38	12	-	-	PUNCT
ctmj-148	38	13	glucopyranoside	glucopyranoside	NOUN
ctmj-148	38	14	(	(	PUNCT
ctmj-148	38	15	lot	lot	NOUN
ctmj-148	38	16	code	code	NOUN
ctmj-148	38	17	:	:	PUNCT
ctmj-148	38	18	23313	23313	NUM
ctmj-148	38	19	-	-	SYM
ctmj-148	38	20	21	21	NUM
ctmj-148	38	21	-	-	SYM
ctmj-148	38	22	5	5	NUM
ctmj-148	38	23	,	,	PUNCT
ctmj-148	38	24	>	>	NOUN
ctmj-148	38	25	95	95	NUM
ctmj-148	38	26	%	%	NOUN
ctmj-148	38	27	)	)	PUNCT
ctmj-148	38	28	,	,	PUNCT
ctmj-148	38	29	aloe	aloe	PROPN
ctmj-148	38	30	-	-	PUNCT
ctmj-148	38	31	emodin-8	emodin-8	NUM
ctmj-148	38	32	-	-	PUNCT
ctmj-148	38	33	o	o	NOUN
ctmj-148	38	34	-	-	PUNCT
ctmj-148	38	35	b	b	NOUN
ctmj-148	38	36	-	-	PUNCT
ctmj-148	38	37	d	d	NOUN
ctmj-148	38	38	-	-	PUNCT
ctmj-148	38	39	glucopyranoside	glucopyranoside	NOUN
ctmj-148	38	40	(	(	PUNCT
ctmj-148	38	41	lot	lot	NOUN
ctmj-148	38	42	code	code	NOUN
ctmj-148	38	43	:	:	PUNCT
ctmj-148	38	44	33037	33037	NUM
ctmj-148	38	45	-	-	SYM
ctmj-148	38	46	46	46	NUM
ctmj-148	38	47	-	-	SYM
ctmj-148	38	48	6	6	NUM
ctmj-148	38	49	,	,	PUNCT
ctmj-148	38	50	>	>	NOUN
ctmj-148	38	51	95	95	NUM
ctmj-148	38	52	%	%	NOUN
ctmj-148	38	53	)	)	PUNCT
ctmj-148	38	54	,	,	PUNCT
ctmj-148	38	55	and	and	CCONJ
ctmj-148	38	56	sennoside	sennoside	NOUN
ctmj-148	38	57	c	c	PROPN
ctmj-148	38	58	(	(	PUNCT
ctmj-148	38	59	lot	lot	PROPN
ctmj-148	38	60	code	code	NOUN
ctmj-148	38	61	:	:	PUNCT
ctmj-148	38	62	37271	37271	NUM
ctmj-148	38	63	-	-	SYM
ctmj-148	38	64	16	16	NUM
ctmj-148	38	65	-	-	SYM
ctmj-148	38	66	2	2	NUM
ctmj-148	38	67	,	,	PUNCT
ctmj-148	38	68	ctmj	ctmj	NOUN
ctmj-148	38	69	|	|	ADV
ctmj-148	38	70	traditionalmedicinejournals.com	traditionalmedicinejournals.com	X
ctmj-148	38	71	issn	issn	PROPN
ctmj-148	38	72	:	:	PUNCT
ctmj-148	38	73	2693	2693	NUM
ctmj-148	38	74	6356	6356	NUM
ctmj-148	38	75	2024	2024	NUM
ctmj-148	38	76	|	|	ADV
ctmj-148	38	77	vol	vol	NOUN
ctmj-148	38	78	7	7	NUM
ctmj-148	38	79	|	|	NOUN
ctmj-148	38	80	issue	issue	NOUN
ctmj-148	38	81	1	1	NUM
ctmj-148	38	82	—	—	PUNCT
ctmj-148	38	83	>	>	PUNCT
ctmj-148	38	84	95	95	NUM
ctmj-148	38	85	%	%	NOUN
ctmj-148	38	86	)	)	PUNCT
ctmj-148	38	87	were	be	AUX
ctmj-148	38	88	purchased	purchase	VERB
ctmj-148	38	89	from	from	ADP
ctmj-148	38	90	chengdu	chengdu	PROPN
ctmj-148	38	91	biopurify	biopurify	PROPN
ctmj-148	38	92	phy	phy	NOUN
ctmj-148	38	93	tochemicals	tochemical	NOUN
ctmj-148	38	94	(	(	PUNCT
ctmj-148	38	95	sichuan	sichuan	PROPN
ctmj-148	38	96	,	,	PUNCT
ctmj-148	38	97	china	china	PROPN
ctmj-148	38	98	)	)	PUNCT
ctmj-148	38	99	.	.	PUNCT
ctmj-148	39	1	mass	mass	ADJ
ctmj-148	39	2	spectrometry	spectrometry	NOUN
ctmj-148	39	3	grade	grade	NOUN
ctmj-148	39	4	acetonitrile	acetonitrile	NOUN
ctmj-148	39	5	,	,	PUNCT
ctmj-148	39	6	methanol	methanol	NOUN
ctmj-148	39	7	,	,	PUNCT
ctmj-148	39	8	and	and	CCONJ
ctmj-148	39	9	formic	formic	PROPN
ctmj-148	39	10	acid	acid	PROPN
ctmj-148	39	11	were	be	AUX
ctmj-148	39	12	obtained	obtain	VERB
ctmj-148	39	13	from	from	ADP
ctmj-148	39	14	thermo	thermo	NOUN
ctmj-148	39	15	fisher	fisher	PROPN
ctmj-148	39	16	scientific	scientific	ADJ
ctmj-148	39	17	(	(	PUNCT
ctmj-148	39	18	fair	fair	ADJ
ctmj-148	39	19	lawn	lawn	NOUN
ctmj-148	39	20	,	,	PUNCT
ctmj-148	39	21	nj	nj	PROPN
ctmj-148	39	22	)	)	PUNCT
ctmj-148	39	23	.	.	PUNCT
ctmj-148	40	1	ultrapure	ultrapure	NOUN
ctmj-148	40	2	water	water	NOUN
ctmj-148	40	3	was	be	AUX
ctmj-148	40	4	obtained	obtain	VERB
ctmj-148	40	5	using	use	VERB
ctmj-148	40	6	a	a	DET
ctmj-148	40	7	synergy	synergy	NOUN
ctmj-148	40	8	uv	uv	NOUN
ctmj-148	40	9	water	water	NOUN
ctmj-148	40	10	purification	purification	NOUN
ctmj-148	40	11	system	system	NOUN
ctmj-148	40	12	(	(	PUNCT
ctmj-148	40	13	millipore	millipore	PROPN
ctmj-148	40	14	,	,	PUNCT
ctmj-148	40	15	billerica	billerica	PROPN
ctmj-148	40	16	,	,	PUNCT
ctmj-148	40	17	ma	ma	PROPN
ctmj-148	40	18	)	)	PUNCT
ctmj-148	40	19	.	.	PUNCT
ctmj-148	41	1	preparation	preparation	NOUN
ctmj-148	41	2	of	of	ADP
ctmj-148	41	3	references	reference	NOUN
ctmj-148	41	4	and	and	CCONJ
ctmj-148	41	5	rhubarb	rhubarb	ADJ
ctmj-148	41	6	extracts	extract	NOUN
ctmj-148	41	7	we	we	PRON
ctmj-148	41	8	weighed	weigh	VERB
ctmj-148	41	9	and	and	CCONJ
ctmj-148	41	10	dissolved	dissolve	VERB
ctmj-148	41	11	compounds	compound	NOUN
ctmj-148	41	12	in	in	ADP
ctmj-148	41	13	suitable	suitable	ADJ
ctmj-148	41	14	volumes	volume	NOUN
ctmj-148	41	15	of	of	ADP
ctmj-148	41	16	0.5	0.5	NUM
ctmj-148	41	17	%	%	NOUN
ctmj-148	41	18	sodium	sodium	NOUN
ctmj-148	41	19	carboxymethylcellulose	carboxymethylcellulose	NOUN
ctmj-148	41	20	to	to	PART
ctmj-148	41	21	prepare	prepare	VERB
ctmj-148	41	22	reference	reference	NOUN
ctmj-148	41	23	samples	sample	NOUN
ctmj-148	41	24	(	(	PUNCT
ctmj-148	41	25	supplemental	supplemental	ADJ
ctmj-148	41	26	table	table	NOUN
ctmj-148	41	27	1	1	NUM
ctmj-148	41	28	)	)	PUNCT
ctmj-148	41	29	.	.	PUNCT
ctmj-148	42	1	the	the	DET
ctmj-148	42	2	rhubarb	rhubarb	NOUN
ctmj-148	42	3	herbal	herbal	ADJ
ctmj-148	42	4	medicine	medicine	NOUN
ctmj-148	42	5	(	(	PUNCT
ctmj-148	42	6	31.0	31.0	NUM
ctmj-148	42	7	g	g	NOUN
ctmj-148	42	8	)	)	PUNCT
ctmj-148	42	9	powder	powder	NOUN
ctmj-148	42	10	was	be	AUX
ctmj-148	42	11	weighed	weigh	VERB
ctmj-148	42	12	,	,	PUNCT
ctmj-148	42	13	300	300	NUM
ctmj-148	42	14	ml	ml	ADP
ctmj-148	42	15	ultra	ultra	ADJ
ctmj-148	42	16	-	-	ADJ
ctmj-148	42	17	pure	pure	ADJ
ctmj-148	42	18	water	water	NOUN
ctmj-148	42	19	was	be	AUX
ctmj-148	42	20	added	add	VERB
ctmj-148	42	21	,	,	PUNCT
ctmj-148	42	22	then	then	ADV
ctmj-148	42	23	the	the	DET
ctmj-148	42	24	suspension	suspension	NOUN
ctmj-148	42	25	was	be	AUX
ctmj-148	42	26	boiled	boil	VERB
ctmj-148	42	27	for	for	ADP
ctmj-148	42	28	20	20	NUM
ctmj-148	42	29	min	min	NOUN
ctmj-148	42	30	at	at	ADP
ctmj-148	42	31	100	100	NUM
ctmj-148	42	32	◦	◦	NOUN
ctmj-148	42	33	c.	c.	NOUN
ctmj-148	42	34	the	the	DET
ctmj-148	42	35	extracted	extract	VERB
ctmj-148	42	36	solution	solution	NOUN
ctmj-148	42	37	was	be	AUX
ctmj-148	42	38	evaporated	evaporate	VERB
ctmj-148	42	39	to	to	ADP
ctmj-148	42	40	100	100	NUM
ctmj-148	42	41	ml	ml	NOUN
ctmj-148	42	42	.	.	PUNCT
ctmj-148	43	1	rhubarb	rhubarb	NOUN
ctmj-148	43	2	should	should	AUX
ctmj-148	43	3	be	be	AUX
ctmj-148	43	4	used	use	VERB
ctmj-148	43	5	at	at	ADP
ctmj-148	43	6	a	a	DET
ctmj-148	43	7	dose	dose	NOUN
ctmj-148	43	8	of	of	ADP
ctmj-148	43	9	0.05e0.25	0.05e0.25	PROPN
ctmj-148	43	10	g	g	PROPN
ctmj-148	43	11	/	/	SYM
ctmj-148	43	12	kg	kg	NOUN
ctmj-148	43	13	/	/	SYM
ctmj-148	43	14	day	day	NOUN
ctmj-148	43	15	in	in	ADP
ctmj-148	43	16	humans	human	NOUN
ctmj-148	43	17	,	,	PUNCT
ctmj-148	43	18	according	accord	VERB
ctmj-148	43	19	to	to	ADP
ctmj-148	43	20	the	the	DET
ctmj-148	43	21	pharmacopoeia	pharmacopoeia	NOUN
ctmj-148	43	22	of	of	ADP
ctmj-148	43	23	the	the	DET
ctmj-148	43	24	people	people	NOUN
ctmj-148	43	25	’s	’s	PART
ctmj-148	43	26	republic	republic	NOUN
ctmj-148	43	27	of	of	ADP
ctmj-148	43	28	china	china	PROPN
ctmj-148	43	29	(	(	PUNCT
ctmj-148	43	30	2015).16	2015).16	NUM
ctmj-148	43	31	according	accord	VERB
ctmj-148	43	32	to	to	ADP
ctmj-148	43	33	the	the	DET
ctmj-148	43	34	doseeconversion	doseeconversion	NOUN
ctmj-148	43	35	relationship	relationship	NOUN
ctmj-148	43	36	between	between	ADP
ctmj-148	43	37	human	human	NOUN
ctmj-148	43	38	and	and	CCONJ
ctmj-148	43	39	rat	rat	NOUN
ctmj-148	43	40	,	,	PUNCT
ctmj-148	43	41	the	the	DET
ctmj-148	43	42	dose	dose	NOUN
ctmj-148	43	43	for	for	ADP
ctmj-148	43	44	rats	rat	NOUN
ctmj-148	43	45	was	be	AUX
ctmj-148	43	46	0.31e1.54	0.31e1.54	NUM
ctmj-148	43	47	g	g	NOUN
ctmj-148	43	48	/	/	SYM
ctmj-148	43	49	kg	kg	PROPN
ctmj-148	43	50	/	/	SYM
ctmj-148	43	51	day	day	NOUN
ctmj-148	43	52	.	.	PUNCT
ctmj-148	44	1	in	in	ADP
ctmj-148	44	2	our	our	PRON
ctmj-148	44	3	previous	previous	ADJ
ctmj-148	44	4	study	study	NOUN
ctmj-148	44	5	,	,	PUNCT
ctmj-148	44	6	we	we	PRON
ctmj-148	44	7	showed	show	VERB
ctmj-148	44	8	that	that	SCONJ
ctmj-148	44	9	the	the	DET
ctmj-148	44	10	administration	administration	NOUN
ctmj-148	44	11	of	of	ADP
ctmj-148	44	12	1.54	1.54	NUM
ctmj-148	44	13	g	g	NOUN
ctmj-148	44	14	/	/	SYM
ctmj-148	44	15	kg/	kg/	NOUN
ctmj-148	44	16	day	day	NOUN
ctmj-148	44	17	of	of	ADP
ctmj-148	44	18	a	a	DET
ctmj-148	44	19	rhubarb	rhubarb	NOUN
ctmj-148	44	20	extract	extract	NOUN
ctmj-148	44	21	for	for	ADP
ctmj-148	44	22	3	3	NUM
ctmj-148	44	23	days	day	NOUN
ctmj-148	44	24	exerted	exert	VERB
ctmj-148	44	25	an	an	DET
ctmj-148	44	26	effective	effective	ADJ
ctmj-148	44	27	laxative	laxative	NOUN
ctmj-148	44	28	in	in	ADP
ctmj-148	44	29	rats	rat	NOUN
ctmj-148	44	30	.	.	PUNCT
ctmj-148	45	1	rat	rat	NOUN
ctmj-148	45	2	model	model	NOUN
ctmj-148	45	3	of	of	ADP
ctmj-148	45	4	constipation	constipation	NOUN
ctmj-148	45	5	and	and	CCONJ
ctmj-148	45	6	rhubarb	rhubarb	PROPN
ctmj-148	45	7	administration	administration	NOUN
ctmj-148	45	8	thirty	thirty	NUM
ctmj-148	45	9	rats	rat	NOUN
ctmj-148	45	10	were	be	AUX
ctmj-148	45	11	acclimatized	acclimatize	VERB
ctmj-148	45	12	for	for	ADP
ctmj-148	45	13	7	7	NUM
ctmj-148	45	14	days	day	NOUN
ctmj-148	45	15	,	,	PUNCT
ctmj-148	45	16	then	then	ADV
ctmj-148	45	17	allocated	allocate	VERB
ctmj-148	45	18	to	to	ADP
ctmj-148	45	19	three	three	NUM
ctmj-148	45	20	groups	group	NOUN
ctmj-148	45	21	:	:	PUNCT
ctmj-148	45	22	control	control	NOUN
ctmj-148	45	23	,	,	PUNCT
ctmj-148	45	24	model	model	NOUN
ctmj-148	45	25	,	,	PUNCT
ctmj-148	45	26	and	and	CCONJ
ctmj-148	45	27	treatment	treatment	NOUN
ctmj-148	45	28	.	.	PUNCT
ctmj-148	46	1	the	the	DET
ctmj-148	46	2	control	control	NOUN
ctmj-148	46	3	group	group	NOUN
ctmj-148	46	4	was	be	AUX
ctmj-148	46	5	administered	administer	VERB
ctmj-148	46	6	saline	saline	NOUN
ctmj-148	46	7	solution	solution	NOUN
ctmj-148	46	8	,	,	PUNCT
ctmj-148	46	9	and	and	CCONJ
ctmj-148	46	10	the	the	DET
ctmj-148	46	11	model	model	NOUN
ctmj-148	46	12	and	and	CCONJ
ctmj-148	46	13	treatment	treatment	NOUN
ctmj-148	46	14	groups	group	NOUN
ctmj-148	46	15	were	be	AUX
ctmj-148	46	16	administered	administer	VERB
ctmj-148	46	17	loperamide	loperamide	ADV
ctmj-148	46	18	at	at	ADP
ctmj-148	46	19	a	a	DET
ctmj-148	46	20	dose	dose	NOUN
ctmj-148	46	21	of	of	ADP
ctmj-148	46	22	1.5	1.5	NUM
ctmj-148	46	23	mg	mg	PROPN
ctmj-148	46	24	/	/	SYM
ctmj-148	46	25	kg	kg	NOUN
ctmj-148	46	26	/	/	SYM
ctmj-148	46	27	day	day	NOUN
ctmj-148	46	28	twice	twice	ADV
ctmj-148	46	29	daily	daily	ADV
ctmj-148	46	30	for	for	ADP
ctmj-148	46	31	7	7	NUM
ctmj-148	46	32	days	day	NOUN
ctmj-148	46	33	by	by	ADP
ctmj-148	46	34	gavage	gavage	NOUN
ctmj-148	46	35	to	to	PART
ctmj-148	46	36	induce	induce	VERB
ctmj-148	46	37	constipation	constipation	NOUN
ctmj-148	46	38	.	.	PUNCT
ctmj-148	47	1	during	during	ADP
ctmj-148	47	2	the	the	DET
ctmj-148	47	3	first	first	ADJ
ctmj-148	47	4	6	6	NUM
ctmj-148	47	5	days	day	NOUN
ctmj-148	47	6	,	,	PUNCT
ctmj-148	47	7	the	the	DET
ctmj-148	47	8	wet	wet	ADJ
ctmj-148	47	9	and	and	CCONJ
ctmj-148	47	10	dry	dry	ADJ
ctmj-148	47	11	masses	masse	NOUN
ctmj-148	47	12	of	of	ADP
ctmj-148	47	13	the	the	DET
ctmj-148	47	14	fecal	fecal	ADJ
ctmj-148	47	15	pellets	pellet	NOUN
ctmj-148	47	16	produced	produce	VERB
ctmj-148	47	17	by	by	ADP
ctmj-148	47	18	the	the	DET
ctmj-148	47	19	rats	rat	NOUN
ctmj-148	47	20	were	be	AUX
ctmj-148	47	21	measured	measure	VERB
ctmj-148	47	22	each	each	DET
ctmj-148	47	23	day.17	day.17	NOUN
ctmj-148	47	24	after	after	SCONJ
ctmj-148	47	25	the	the	DET
ctmj-148	47	26	model	model	NOUN
ctmj-148	47	27	of	of	ADP
ctmj-148	47	28	constipation	constipation	NOUN
ctmj-148	47	29	had	have	AUX
ctmj-148	47	30	been	be	AUX
ctmj-148	47	31	successfully	successfully	ADV
ctmj-148	47	32	established	establish	VERB
ctmj-148	47	33	,	,	PUNCT
ctmj-148	47	34	the	the	DET
ctmj-148	47	35	treatment	treatment	NOUN
ctmj-148	47	36	group	group	NOUN
ctmj-148	47	37	was	be	AUX
ctmj-148	47	38	fed	feed	VERB
ctmj-148	47	39	with	with	ADP
ctmj-148	47	40	rhubarb	rhubarb	NOUN
ctmj-148	47	41	extract	extract	NOUN
ctmj-148	47	42	at	at	ADP
ctmj-148	47	43	a	a	DET
ctmj-148	47	44	dose	dose	NOUN
ctmj-148	47	45	of	of	ADP
ctmj-148	47	46	1.54	1.54	NUM
ctmj-148	47	47	g	g	NOUN
ctmj-148	47	48	/	/	SYM
ctmj-148	47	49	kg	kg	NOUN
ctmj-148	47	50	/	/	SYM
ctmj-148	47	51	day	day	NOUN
ctmj-148	47	52	for	for	ADP
ctmj-148	47	53	3	3	NUM
ctmj-148	47	54	days	day	NOUN
ctmj-148	47	55	,	,	PUNCT
ctmj-148	47	56	during	during	ADP
ctmj-148	47	57	which	which	PRON
ctmj-148	47	58	the	the	DET
ctmj-148	47	59	other	other	ADJ
ctmj-148	47	60	groups	group	NOUN
ctmj-148	47	61	were	be	AUX
ctmj-148	47	62	administered	administer	VERB
ctmj-148	47	63	substances	substance	NOUN
ctmj-148	47	64	as	as	ADP
ctmj-148	47	65	above	above	ADV
ctmj-148	47	66	.	.	PUNCT
ctmj-148	48	1	the	the	DET
ctmj-148	48	2	evacuation	evacuation	NOUN
ctmj-148	48	3	index	index	NOUN
ctmj-148	48	4	(	(	PUNCT
ctmj-148	48	5	ei	ei	NOUN
ctmj-148	48	6	)	)	PUNCT
ctmj-148	48	7	was	be	AUX
ctmj-148	48	8	used	use	VERB
ctmj-148	48	9	to	to	PART
ctmj-148	48	10	evaluate	evaluate	VERB
ctmj-148	48	11	the	the	DET
ctmj-148	48	12	laxative	laxative	ADJ
ctmj-148	48	13	effect	effect	NOUN
ctmj-148	48	14	of	of	ADP
ctmj-148	48	15	rhubarb.18	rhubarb.18	NOUN
ctmj-148	48	16	in	in	ADP
ctmj-148	48	17	addition	addition	NOUN
ctmj-148	48	18	,	,	PUNCT
ctmj-148	48	19	the	the	DET
ctmj-148	48	20	feces	fece	NOUN
ctmj-148	48	21	of	of	ADP
ctmj-148	48	22	rats	rat	NOUN
ctmj-148	48	23	in	in	ADP
ctmj-148	48	24	the	the	DET
ctmj-148	48	25	treatment	treatment	NOUN
ctmj-148	48	26	group	group	NOUN
ctmj-148	48	27	were	be	AUX
ctmj-148	48	28	collected	collect	VERB
ctmj-148	48	29	for	for	ADP
ctmj-148	48	30	analysis	analysis	NOUN
ctmj-148	48	31	.	.	PUNCT
ctmj-148	49	1	all	all	DET
ctmj-148	49	2	the	the	DET
ctmj-148	49	3	rats	rat	NOUN
ctmj-148	49	4	were	be	AUX
ctmj-148	49	5	sacrificed	sacrifice	VERB
ctmj-148	49	6	on	on	ADP
ctmj-148	49	7	the	the	DET
ctmj-148	49	8	10th	10th	ADJ
ctmj-148	49	9	day	day	NOUN
ctmj-148	49	10	,	,	PUNCT
ctmj-148	49	11	their	their	PRON
ctmj-148	49	12	mid	mid	NOUN
ctmj-148	49	13	-	-	NOUN
ctmj-148	49	14	colons	colon	NOUN
ctmj-148	49	15	were	be	AUX
ctmj-148	49	16	collected	collect	VERB
ctmj-148	49	17	,	,	PUNCT
ctmj-148	49	18	snap	snap	NOUN
ctmj-148	49	19	-	-	PUNCT
ctmj-148	49	20	frozen	frozen	ADJ
ctmj-148	49	21	in	in	ADP
ctmj-148	49	22	liquid	liquid	ADJ
ctmj-148	49	23	nitrogen	nitrogen	NOUN
ctmj-148	49	24	,	,	PUNCT
ctmj-148	49	25	and	and	CCONJ
ctmj-148	49	26	stored	store	VERB
ctmj-148	49	27	at	at	ADP
ctmj-148	49	28	80	80	NUM
ctmj-148	49	29	◦	◦	NOUN
ctmj-148	49	30	c	c	NOUN
ctmj-148	49	31	until	until	ADP
ctmj-148	49	32	western	western	ADJ
ctmj-148	49	33	blot	blot	NOUN
ctmj-148	49	34	analysis	analysis	NOUN
ctmj-148	49	35	.	.	PUNCT
ctmj-148	50	1	animals	animal	NOUN
ctmj-148	50	2	specific	specific	ADJ
ctmj-148	50	3	pathogen	pathogen	NOUN
ctmj-148	50	4	-	-	PUNCT
ctmj-148	50	5	free	free	ADJ
ctmj-148	50	6	male	male	NOUN
ctmj-148	50	7	sprague	sprague	NOUN
ctmj-148	50	8	-	-	PUNCT
ctmj-148	50	9	dawley	dawley	NOUN
ctmj-148	50	10	rats	rat	NOUN
ctmj-148	50	11	weighing	weigh	VERB
ctmj-148	50	12	200	200	NUM
ctmj-148	50	13	±	±	NUM
ctmj-148	50	14	20	20	NUM
ctmj-148	50	15	g	g	NOUN
ctmj-148	50	16	were	be	AUX
ctmj-148	50	17	obtained	obtain	VERB
ctmj-148	50	18	from	from	ADP
ctmj-148	50	19	beijing	beijing	PROPN
ctmj-148	50	20	vital	vital	PROPN
ctmj-148	50	21	river	river	NOUN
ctmj-148	50	22	laboratory	laboratory	NOUN
ctmj-148	50	23	animal	animal	NOUN
ctmj-148	50	24	technology	technology	NOUN
ctmj-148	50	25	(	(	PUNCT
ctmj-148	50	26	beijing	beijing	PROPN
ctmj-148	50	27	,	,	PUNCT
ctmj-148	50	28	china	china	PROPN
ctmj-148	50	29	)	)	PUNCT
ctmj-148	50	30	and	and	CCONJ
ctmj-148	50	31	maintained	maintain	VERB
ctmj-148	50	32	at	at	ADP
ctmj-148	50	33	a	a	DET
ctmj-148	50	34	constant	constant	ADJ
ctmj-148	50	35	temperature	temperature	NOUN
ctmj-148	50	36	(	(	PUNCT
ctmj-148	50	37	23	23	NUM
ctmj-148	50	38	±	±	NUM
ctmj-148	50	39	2	2	NUM
ctmj-148	50	40	◦	◦	NOUN
ctmj-148	50	41	c	c	NOUN
ctmj-148	50	42	)	)	PUNCT
ctmj-148	50	43	and	and	CCONJ
ctmj-148	50	44	humidity	humidity	NOUN
ctmj-148	50	45	(	(	PUNCT
ctmj-148	50	46	60	60	NUM
ctmj-148	50	47	±	±	NUM
ctmj-148	50	48	5	5	NUM
ctmj-148	50	49	%	%	NOUN
ctmj-148	50	50	)	)	PUNCT
ctmj-148	50	51	.	.	PUNCT
ctmj-148	51	1	identification	identification	NOUN
ctmj-148	51	2	of	of	ADP
ctmj-148	51	3	rhubarb	rhubarb	NOUN
ctmj-148	51	4	derivatives	derivative	NOUN
ctmj-148	51	5	in	in	ADP
ctmj-148	51	6	feces	fece	NOUN
ctmj-148	51	7	preparation	preparation	NOUN
ctmj-148	51	8	of	of	ADP
ctmj-148	51	9	samples	sample	NOUN
ctmj-148	51	10	fecal	fecal	ADJ
ctmj-148	51	11	samples	sample	NOUN
ctmj-148	51	12	were	be	AUX
ctmj-148	51	13	collected	collect	VERB
ctmj-148	51	14	over	over	ADP
ctmj-148	51	15	a	a	DET
ctmj-148	51	16	24	24	NUM
ctmj-148	51	17	-	-	PUNCT
ctmj-148	51	18	h	h	NOUN
ctmj-148	51	19	period	period	NOUN
ctmj-148	51	20	from	from	ADP
ctmj-148	51	21	another	another	DET
ctmj-148	51	22	20sprague	20sprague	NOUN
ctmj-148	51	23	-	-	PUNCT
ctmj-148	51	24	dawley	dawley	NOUN
ctmj-148	51	25	rats	rat	NOUN
ctmj-148	51	26	that	that	PRON
ctmj-148	51	27	had	have	AUX
ctmj-148	51	28	been	be	AUX
ctmj-148	51	29	administered	administer	VERB
ctmj-148	51	30	solutions	solution	NOUN
ctmj-148	51	31	of	of	ADP
ctmj-148	51	32	10	10	NUM
ctmj-148	51	33	reference	reference	NOUN
ctmj-148	51	34	substances	substance	NOUN
ctmj-148	51	35	.	.	PUNCT
ctmj-148	52	1	these	these	DET
ctmj-148	52	2	feces	fece	NOUN
ctmj-148	52	3	were	be	AUX
ctmj-148	52	4	dried	dry	VERB
ctmj-148	52	5	in	in	ADP
ctmj-148	52	6	a	a	DET
ctmj-148	52	7	ventilator	ventilator	NOUN
ctmj-148	52	8	,	,	PUNCT
ctmj-148	52	9	crushed	crush	VERB
ctmj-148	52	10	,	,	PUNCT
ctmj-148	52	11	and	and	CCONJ
ctmj-148	52	12	then	then	ADV
ctmj-148	52	13	placed	place	VERB
ctmj-148	52	14	in	in	ADP
ctmj-148	52	15	a	a	DET
ctmj-148	52	16	centrifuge	centrifuge	NOUN
ctmj-148	52	17	tube	tube	NOUN
ctmj-148	52	18	.	.	PUNCT
ctmj-148	53	1	fecal	fecal	ADJ
ctmj-148	53	2	samples	sample	NOUN
ctmj-148	53	3	weighing	weigh	VERB
ctmj-148	53	4	20	20	NUM
ctmj-148	53	5	mg	mg	NUM
ctmj-148	53	6	were	be	AUX
ctmj-148	53	7	extracted	extract	VERB
ctmj-148	53	8	using	use	VERB
ctmj-148	53	9	200	200	NUM
ctmj-148	53	10	ml	ml	NUM
ctmj-148	53	11	80	80	NUM
ctmj-148	53	12	%	%	NOUN
ctmj-148	53	13	methanol	methanol	NOUN
ctmj-148	53	14	and	and	CCONJ
ctmj-148	53	15	vortex	vortex	NOUN
ctmj-148	53	16	-	-	PUNCT
ctmj-148	53	17	mixed	mixed	ADJ
ctmj-148	53	18	for	for	ADP
ctmj-148	53	19	30	30	NUM
ctmj-148	53	20	min	min	NOUN
ctmj-148	53	21	.	.	PROPN
ctmj-148	54	1	then	then	ADV
ctmj-148	54	2	,	,	PUNCT
ctmj-148	54	3	the	the	DET
ctmj-148	54	4	samples	sample	NOUN
ctmj-148	54	5	were	be	AUX
ctmj-148	54	6	centrifuged	centrifuge	VERB
ctmj-148	54	7	at	at	ADP
ctmj-148	54	8	13	13	NUM
ctmj-148	54	9	522×g	522×g	PROPN
ctmj-148	54	10	at	at	ADP
ctmj-148	54	11	4	4	NUM
ctmj-148	54	12	◦	◦	NOUN
ctmj-148	54	13	c	c	NOUN
ctmj-148	54	14	for	for	ADP
ctmj-148	54	15	15	15	NUM
ctmj-148	54	16	min	min	NOUN
ctmj-148	54	17	and	and	CCONJ
ctmj-148	54	18	the	the	DET
ctmj-148	54	19	supernatant	supernatant	NOUN
ctmj-148	54	20	was	be	AUX
ctmj-148	54	21	evaporated	evaporate	VERB
ctmj-148	54	22	to	to	PART
ctmj-148	54	23	dryness	dryness	VERB
ctmj-148	54	24	under	under	ADP
ctmj-148	54	25	nitrogen	nitrogen	NOUN
ctmj-148	54	26	.	.	PUNCT
ctmj-148	55	1	the	the	DET
ctmj-148	55	2	residue	residue	NOUN
ctmj-148	55	3	was	be	AUX
ctmj-148	55	4	reconstituted	reconstitute	VERB
ctmj-148	55	5	with	with	ADP
ctmj-148	55	6	200	200	NUM
ctmj-148	55	7	ml	ml	NOUN
ctmj-148	55	8	of	of	ADP
ctmj-148	55	9	50	50	NUM
ctmj-148	55	10	%	%	NOUN
ctmj-148	55	11	methanol	methanol	NOUN
ctmj-148	55	12	,	,	PUNCT
ctmj-148	55	13	vortex	vortex	NOUN
ctmj-148	55	14	-	-	PUNCT
ctmj-148	55	15	mixed	mixed	ADJ
ctmj-148	55	16	for	for	ADP
ctmj-148	55	17	3	3	NUM
ctmj-148	55	18	min	min	NOUN
ctmj-148	55	19	,	,	PUNCT
ctmj-148	55	20	then	then	ADV
ctmj-148	55	21	centrifuged	centrifuge	VERB
ctmj-148	55	22	at	at	ADP
ctmj-148	55	23	13	13	NUM
ctmj-148	55	24	522×g	522×g	PROPN
ctmj-148	55	25	at	at	ADP
ctmj-148	55	26	4	4	NUM
ctmj-148	55	27	◦	◦	NOUN
ctmj-148	55	28	c	c	NOUN
ctmj-148	55	29	for	for	ADP
ctmj-148	55	30	10	10	NUM
ctmj-148	55	31	min	min	NOUN
ctmj-148	55	32	.	.	PROPN
ctmj-148	55	33	chromatography	chromatography	NOUN
ctmj-148	55	34	and	and	CCONJ
ctmj-148	55	35	ms	ms	NOUN
ctmj-148	55	36	conditions	condition	NOUN
ctmj-148	55	37	we	we	PRON
ctmj-148	55	38	used	use	VERB
ctmj-148	55	39	previously	previously	ADV
ctmj-148	55	40	optimized	optimize	VERB
ctmj-148	55	41	chromatographic	chromatographic	ADJ
ctmj-148	55	42	and	and	CCONJ
ctmj-148	55	43	ms	ms	NOUN
ctmj-148	55	44	conditions.19	conditions.19	NOUN
ctmj-148	55	45	data	datum	NOUN
ctmj-148	55	46	processing	process	VERB
ctmj-148	55	47	the	the	DET
ctmj-148	55	48	raw	raw	ADJ
ctmj-148	55	49	mass	mass	NOUN
ctmj-148	55	50	data	datum	NOUN
ctmj-148	55	51	generated	generate	VERB
ctmj-148	55	52	by	by	ADP
ctmj-148	55	53	the	the	DET
ctmj-148	55	54	hplc	hplc	NOUN
ctmj-148	55	55	-	-	PUNCT
ctmj-148	55	56	ltq	ltq	NOUN
ctmj-148	55	57	-	-	PUNCT
ctmj-148	55	58	orbitrap	orbitrap	NOUN
ctmj-148	55	59	ms	ms	NOUN
ctmj-148	55	60	analysis	analysis	NOUN
ctmj-148	55	61	were	be	AUX
ctmj-148	55	62	processed	process	VERB
ctmj-148	55	63	using	use	VERB
ctmj-148	55	64	qual	qual	ADJ
ctmj-148	55	65	browser	browser	NOUN
ctmj-148	55	66	of	of	ADP
ctmj-148	55	67	xcalibur	xcalibur	PROPN
ctmj-148	55	68	2.1	2.1	NUM
ctmj-148	55	69	(	(	PUNCT
ctmj-148	55	70	thermo	thermo	NOUN
ctmj-148	55	71	fisher	fisher	PROPN
ctmj-148	55	72	scientific	scientific	PROPN
ctmj-148	55	73	,	,	PUNCT
ctmj-148	55	74	san	san	PROPN
ctmj-148	55	75	jose	jose	PROPN
ctmj-148	55	76	,	,	PUNCT
ctmj-148	55	77	ca	ca	NOUN
ctmj-148	55	78	)	)	PUNCT
ctmj-148	55	79	.	.	PUNCT
ctmj-148	56	1	online	online	ADJ
ctmj-148	56	2	chemical	chemical	NOUN
ctmj-148	56	3	databases	database	NOUN
ctmj-148	56	4	(	(	PUNCT
ctmj-148	56	5	http://www.chemspider.com/and	http://www.chemspider.com/and	ADV
ctmj-148	56	6	https://www.ncbi.nlm.nih.gov/	https://www.ncbi.nlm.nih.gov/	ADV
ctmj-148	56	7	)	)	PUNCT
ctmj-148	56	8	were	be	AUX
ctmj-148	56	9	used	use	VERB
ctmj-148	56	10	to	to	PART
ctmj-148	56	11	identify	identify	VERB
ctmj-148	56	12	the	the	DET
ctmj-148	56	13	compounds	compound	NOUN
ctmj-148	56	14	obtained	obtain	VERB
ctmj-148	56	15	.	.	PUNCT
ctmj-148	57	1	the	the	DET
ctmj-148	57	2	identification	identification	NOUN
ctmj-148	57	3	of	of	ADP
ctmj-148	57	4	potentially	potentially	ADV
ctmj-148	57	5	novel	novel	ADJ
ctmj-148	57	6	compounds	compound	NOUN
ctmj-148	57	7	was	be	AUX
ctmj-148	57	8	accomplished	accomplish	VERB
ctmj-148	57	9	using	use	VERB
ctmj-148	57	10	the	the	DET
ctmj-148	57	11	scifinder	scifinder	ADJ
ctmj-148	57	12	database	database	NOUN
ctmj-148	57	13	(	(	PUNCT
ctmj-148	57	14	https://sso.cas.org/	https://sso.cas.org/	NOUN
ctmj-148	57	15	)	)	PUNCT
ctmj-148	57	16	.	.	PUNCT
ctmj-148	58	1	creation	creation	NOUN
ctmj-148	58	2	of	of	ADP
ctmj-148	58	3	a	a	DET
ctmj-148	58	4	laxative	laxative	NOUN
ctmj-148	58	5	target	target	NOUN
ctmj-148	58	6	database	database	NOUN
ctmj-148	58	7	first	first	ADV
ctmj-148	58	8	,	,	PUNCT
ctmj-148	58	9	we	we	PRON
ctmj-148	58	10	used	use	VERB
ctmj-148	58	11	the	the	DET
ctmj-148	58	12	ttd	ttd	NOUN
ctmj-148	58	13	(	(	PUNCT
ctmj-148	58	14	https://db.idrblab.org/ttd/	https://db.idrblab.org/ttd/	NOUN
ctmj-148	58	15	)	)	PUNCT
ctmj-148	58	16	to	to	PART
ctmj-148	58	17	identify	identify	VERB
ctmj-148	58	18	molecular	molecular	ADJ
ctmj-148	58	19	targets	target	NOUN
ctmj-148	58	20	for	for	ADP
ctmj-148	58	21	the	the	DET
ctmj-148	58	22	treatment	treatment	NOUN
ctmj-148	58	23	of	of	ADP
ctmj-148	58	24	constipation	constipation	NOUN
ctmj-148	58	25	and	and	CCONJ
ctmj-148	58	26	the	the	DET
ctmj-148	58	27	drug	drug	NOUN
ctmj-148	58	28	bank	bank	PROPN
ctmj-148	58	29	database	database	NOUN
ctmj-148	58	30	(	(	PUNCT
ctmj-148	58	31	https://www.drugbank.ca/	https://www.drugbank.ca/	NUM
ctmj-148	58	32	)	)	PUNCT
ctmj-148	58	33	to	to	PART
ctmj-148	58	34	summarize	summarize	VERB
ctmj-148	58	35	the	the	DET
ctmj-148	58	36	targets	target	NOUN
ctmj-148	58	37	of	of	ADP
ctmj-148	58	38	existing	exist	VERB
ctmj-148	58	39	laxatives	laxative	NOUN
ctmj-148	58	40	.	.	PUNCT
ctmj-148	59	1	then	then	ADV
ctmj-148	59	2	,	,	PUNCT
ctmj-148	59	3	we	we	PRON
ctmj-148	59	4	searched	search	VERB
ctmj-148	59	5	the	the	DET
ctmj-148	59	6	literature	literature	NOUN
ctmj-148	59	7	to	to	PART
ctmj-148	59	8	further	further	ADJ
ctmj-148	59	9	screen	screen	NOUN
ctmj-148	59	10	for	for	ADP
ctmj-148	59	11	molecular	molecular	ADJ
ctmj-148	59	12	targets	target	NOUN
ctmj-148	59	13	with	with	ADP
ctmj-148	59	14	a	a	DET
ctmj-148	59	15	possible	possible	ADJ
ctmj-148	59	16	laxative	laxative	NOUN
ctmj-148	59	17	effect	effect	NOUN
ctmj-148	59	18	.	.	PUNCT
ctmj-148	60	1	homology	homology	NOUN
ctmj-148	60	2	modeling	model	VERB
ctmj-148	60	3	the	the	DET
ctmj-148	60	4	target	target	NOUN
ctmj-148	60	5	sequences	sequence	NOUN
ctmj-148	60	6	of	of	ADP
ctmj-148	60	7	5	5	NUM
ctmj-148	60	8	-	-	PUNCT
ctmj-148	60	9	ht4	ht4	NOUN
ctmj-148	60	10	and	and	CCONJ
ctmj-148	60	11	aqp3	aqp3	PROPN
ctmj-148	60	12	were	be	AUX
ctmj-148	60	13	acquired	acquire	VERB
ctmj-148	60	14	from	from	ADP
ctmj-148	60	15	uniprot	uniprot	ADJ
ctmj-148	60	16	(	(	PUNCT
ctmj-148	60	17	http://www.uniprot.org/	http://www.uniprot.org/	ADJ
ctmj-148	60	18	;	;	PUNCT
ctmj-148	60	19	uniprot	uniprot	ADJ
ctmj-148	60	20	ids	ids	NOUN
ctmj-148	60	21	q13639	q13639	PROPN
ctmj-148	61	1	[	[	X
ctmj-148	61	2	5ht4	5ht4	NUM
ctmj-148	61	3	]	]	PUNCT
ctmj-148	61	4	and	and	CCONJ
ctmj-148	61	5	q92482	q92482	PROPN
ctmj-148	62	1	[	[	X
ctmj-148	62	2	aqp3	aqp3	NOUN
ctmj-148	62	3	]	]	X
ctmj-148	62	4	)	)	PUNCT
ctmj-148	62	5	.	.	PUNCT
ctmj-148	63	1	template	template	NOUN
ctmj-148	63	2	crystal	crystal	NOUN
ctmj-148	63	3	structures	structure	NOUN
ctmj-148	63	4	for	for	ADP
ctmj-148	63	5	these	these	DET
ctmj-148	63	6	target	target	NOUN
ctmj-148	63	7	sequences	sequence	NOUN
ctmj-148	63	8	were	be	AUX
ctmj-148	63	9	identified	identify	VERB
ctmj-148	63	10	using	use	VERB
ctmj-148	63	11	blast	blast	NOUN
ctmj-148	63	12	and	and	CCONJ
ctmj-148	63	13	downloaded	download	VERB
ctmj-148	63	14	from	from	ADP
ctmj-148	63	15	the	the	DET
ctmj-148	63	16	research	research	NOUN
ctmj-148	63	17	collaboratory	collaboratory	NOUN
ctmj-148	63	18	for	for	ADP
ctmj-148	63	19	structural	structural	ADJ
ctmj-148	63	20	bioinformatics	bioinformatics	NOUN
ctmj-148	63	21	protein	protein	NOUN
ctmj-148	63	22	data	datum	NOUN
ctmj-148	63	23	bank	bank	PROPN
ctmj-148	63	24	(	(	PUNCT
ctmj-148	63	25	rcsb	rcsb	PROPN
ctmj-148	63	26	pdb	pdb	PROPN
ctmj-148	63	27	,	,	PUNCT
ctmj-148	63	28	http://www.rcsb.org/	http://www.rcsb.org/	NOUN
ctmj-148	63	29	)	)	PUNCT
ctmj-148	63	30	,	,	PUNCT
ctmj-148	63	31	using	use	VERB
ctmj-148	63	32	the	the	DET
ctmj-148	63	33	pdb	pdb	PROPN
ctmj-148	63	34	ids	id	NOUN
ctmj-148	63	35	of	of	ADP
ctmj-148	63	36	6h7j	6h7j	NOUN
ctmj-148	63	37	for	for	ADP
ctmj-148	63	38	5	5	NUM
ctmj-148	63	39	-	-	PUNCT
ctmj-148	63	40	ht4	ht4	NOUN
ctmj-148	63	41	and	and	CCONJ
ctmj-148	63	42	6f7h	6f7h	NOUN
ctmj-148	63	43	for	for	ADP
ctmj-148	63	44	aqp3.20	aqp3.20	PROPN
ctmj-148	63	45	moe	moe	NOUN
ctmj-148	63	46	v2014.0901	v2014.0901	NUM
ctmj-148	63	47	software	software	NOUN
ctmj-148	63	48	(	(	PUNCT
ctmj-148	63	49	molecular	molecular	ADJ
ctmj-148	63	50	operating	operating	NOUN
ctmj-148	63	51	environment	environment	NOUN
ctmj-148	63	52	(	(	PUNCT
ctmj-148	63	53	moe	moe	NOUN
ctmj-148	63	54	)	)	PUNCT
ctmj-148	63	55	;	;	PUNCT
ctmj-148	63	56	montreal	montreal	PROPN
ctmj-148	63	57	,	,	PUNCT
ctmj-148	63	58	canada	canada	PROPN
ctmj-148	63	59	)	)	PUNCT
ctmj-148	63	60	was	be	AUX
ctmj-148	63	61	used	use	VERB
ctmj-148	63	62	for	for	ADP
ctmj-148	63	63	homology	homology	NOUN
ctmj-148	63	64	modeling	modeling	NOUN
ctmj-148	63	65	.	.	PUNCT
ctmj-148	64	1	the	the	DET
ctmj-148	64	2	quickprep	quickprep	NOUN
ctmj-148	64	3	module	module	NOUN
ctmj-148	64	4	in	in	ADP
ctmj-148	64	5	moe	moe	NOUN
ctmj-148	64	6	was	be	AUX
ctmj-148	64	7	used	use	VERB
ctmj-148	64	8	to	to	PART
ctmj-148	64	9	determine	determine	VERB
ctmj-148	64	10	the	the	DET
ctmj-148	64	11	likely	likely	ADJ
ctmj-148	64	12	sites	site	NOUN
ctmj-148	64	13	of	of	ADP
ctmj-148	64	14	protonation	protonation	NOUN
ctmj-148	64	15	of	of	ADP
ctmj-148	64	16	the	the	DET
ctmj-148	64	17	proteins	protein	NOUN
ctmj-148	64	18	and	and	CCONJ
ctmj-148	64	19	the	the	DET
ctmj-148	64	20	orientation	orientation	NOUN
ctmj-148	64	21	of	of	ADP
ctmj-148	64	22	hydrogen	hydrogen	NOUN
ctmj-148	64	23	atoms	atom	NOUN
ctmj-148	64	24	in	in	ADP
ctmj-148	64	25	phs	phs	NOUN
ctmj-148	64	26	up	up	ADP
ctmj-148	64	27	to	to	PART
ctmj-148	64	28	7	7	NUM
ctmj-148	64	29	and	and	CCONJ
ctmj-148	64	30	temperatures	temperature	NOUN
ctmj-148	64	31	up	up	ADV
ctmj-148	64	32	to	to	ADP
ctmj-148	64	33	300	300	NUM
ctmj-148	64	34	k.	k.	NOUN
ctmj-148	64	35	first	first	ADV
ctmj-148	64	36	,	,	PUNCT
ctmj-148	64	37	the	the	DET
ctmj-148	64	38	target	target	NOUN
ctmj-148	64	39	sequence	sequence	NOUN
ctmj-148	64	40	was	be	AUX
ctmj-148	64	41	aligned	align	VERB
ctmj-148	64	42	with	with	ADP
ctmj-148	64	43	the	the	DET
ctmj-148	64	44	template	template	NOUN
ctmj-148	64	45	sequence	sequence	NOUN
ctmj-148	64	46	,	,	PUNCT
ctmj-148	64	47	and	and	CCONJ
ctmj-148	64	48	10	10	NUM
ctmj-148	64	49	independent	independent	ADJ
ctmj-148	64	50	intermediate	intermediate	ADJ
ctmj-148	64	51	models	model	NOUN
ctmj-148	64	52	were	be	AUX
ctmj-148	64	53	established	establish	VERB
ctmj-148	64	54	.	.	PUNCT
ctmj-148	65	1	these	these	DET
ctmj-148	65	2	models	model	NOUN
ctmj-148	65	3	,	,	PUNCT
ctmj-148	65	4	with	with	ADP
ctmj-148	65	5	differing	differ	VERB
ctmj-148	65	6	homologies	homology	NOUN
ctmj-148	65	7	,	,	PUNCT
ctmj-148	65	8	were	be	AUX
ctmj-148	65	9	the	the	DET
ctmj-148	65	10	result	result	NOUN
ctmj-148	65	11	of	of	ADP
ctmj-148	65	12	permutational	permutational	ADJ
ctmj-148	65	13	selection	selection	NOUN
ctmj-148	65	14	of	of	ADP
ctmj-148	65	15	different	different	ADJ
ctmj-148	65	16	loop	loop	NOUN
ctmj-148	65	17	candidates	candidate	NOUN
ctmj-148	65	18	and	and	CCONJ
ctmj-148	65	19	side	side	NOUN
ctmj-148	65	20	-	-	PUNCT
ctmj-148	65	21	chain	chain	NOUN
ctmj-148	65	22	rotamers	rotamer	NOUN
ctmj-148	65	23	.	.	PUNCT
ctmj-148	66	1	then	then	ADV
ctmj-148	66	2	,	,	PUNCT
ctmj-148	66	3	we	we	PRON
ctmj-148	66	4	selected	select	VERB
ctmj-148	66	5	the	the	DET
ctmj-148	66	6	intermediate	intermediate	ADJ
ctmj-148	66	7	model	model	NOUN
ctmj-148	66	8	with	with	ADP
ctmj-148	66	9	the	the	DET
ctmj-148	66	10	highest	high	ADJ
ctmj-148	66	11	generalized	generalized	ADJ
ctmj-148	66	12	born	bear	VERB
ctmj-148	66	13	/	/	SYM
ctmj-148	66	14	volume	volume	NOUN
ctmj-148	66	15	integral	integral	ADJ
ctmj-148	66	16	score	score	NOUN
ctmj-148	66	17	as	as	ADP
ctmj-148	66	18	the	the	DET
ctmj-148	66	19	final	final	ADJ
ctmj-148	66	20	model	model	NOUN
ctmj-148	66	21	,	,	PUNCT
ctmj-148	66	22	which	which	PRON
ctmj-148	66	23	was	be	AUX
ctmj-148	66	24	subjected	subject	VERB
ctmj-148	66	25	to	to	ADP
ctmj-148	66	26	further	further	ADJ
ctmj-148	66	27	energy	energy	NOUN
ctmj-148	66	28	minimization	minimization	NOUN
ctmj-148	66	29	using	use	VERB
ctmj-148	66	30	amber10	amber10	PROPN
ctmj-148	66	31	:	:	PUNCT
ctmj-148	66	32	eht	eht	PROPN
ctmj-148	66	33	force	force	PROPN
ctmj-148	66	34	field	field	PROPN
ctmj-148	66	35	(	(	PUNCT
ctmj-148	66	36	moe	moe	NOUN
ctmj-148	66	37	)	)	PUNCT
ctmj-148	66	38	.	.	PUNCT
ctmj-148	67	1	molecular	molecular	ADJ
ctmj-148	67	2	docking	docking	NOUN
ctmj-148	67	3	between	between	ADP
ctmj-148	67	4	rhubarb	rhubarb	NOUN
ctmj-148	67	5	derivatives	derivative	NOUN
ctmj-148	67	6	in	in	ADP
ctmj-148	67	7	the	the	DET
ctmj-148	67	8	colorectum	colorectum	NOUN
ctmj-148	67	9	and	and	CCONJ
ctmj-148	67	10	molecules	molecule	NOUN
ctmj-148	67	11	mediating	mediate	VERB
ctmj-148	67	12	a	a	DET
ctmj-148	67	13	laxative	laxative	ADJ
ctmj-148	67	14	effect	effect	NOUN
ctmj-148	67	15	the	the	DET
ctmj-148	67	16	2d	2d	NUM
ctmj-148	67	17	structures	structure	NOUN
ctmj-148	67	18	of	of	ADP
ctmj-148	67	19	the	the	DET
ctmj-148	67	20	rhubarb	rhubarb	ADJ
ctmj-148	67	21	derivatives	derivative	NOUN
ctmj-148	67	22	were	be	AUX
ctmj-148	67	23	drawn	draw	VERB
ctmj-148	67	24	in	in	ADP
ctmj-148	67	25	chembiodraw	chembiodraw	PROPN
ctmj-148	67	26	2014	2014	NUM
ctmj-148	67	27	and	and	CCONJ
ctmj-148	67	28	chemically	chemically	ADV
ctmj-148	67	29	standardized	standardize	VERB
ctmj-148	67	30	,	,	PUNCT
ctmj-148	67	31	which	which	PRON
ctmj-148	67	32	consisted	consist	VERB
ctmj-148	67	33	of	of	ADP
ctmj-148	67	34	the	the	DET
ctmj-148	67	35	addition	addition	NOUN
ctmj-148	67	36	of	of	ADP
ctmj-148	67	37	hydrogens	hydrogen	NOUN
ctmj-148	67	38	,	,	PUNCT
ctmj-148	67	39	ionization	ionization	NOUN
ctmj-148	67	40	at	at	ADP
ctmj-148	67	41	phs	phs	NOUN
ctmj-148	67	42	from	from	ADP
ctmj-148	67	43	5.1	5.1	NUM
ctmj-148	67	44	to	to	ADP
ctmj-148	67	45	9.1	9.1	NUM
ctmj-148	67	46	,	,	PUNCT
ctmj-148	67	47	and	and	CCONJ
ctmj-148	67	48	the	the	DET
ctmj-148	67	49	formation	formation	NOUN
ctmj-148	67	50	of	of	ADP
ctmj-148	67	51	stereoisomers	stereoisomer	NOUN
ctmj-148	67	52	and	and	CCONJ
ctmj-148	67	53	effective	effective	ADJ
ctmj-148	67	54	single	single	ADJ
ctmj-148	67	55	3d	3d	NOUN
ctmj-148	67	56	conformations	conformation	NOUN
ctmj-148	67	57	using	use	VERB
ctmj-148	67	58	the	the	DET
ctmj-148	67	59	ligprep	ligprep	PROPN
ctmj-148	67	60	module	module	NOUN
ctmj-148	67	61	in	in	ADP
ctmj-148	67	62	maestro	maestro	NOUN
ctmj-148	67	63	(	(	PUNCT
ctmj-148	67	64	version	version	NOUN
ctmj-148	67	65	9.4	9.4	NUM
ctmj-148	67	66	,	,	PUNCT
ctmj-148	67	67	schro€dinger	schro€dinger	NOUN
ctmj-148	67	68	)	)	PUNCT
ctmj-148	67	69	.	.	PUNCT
ctmj-148	68	1	the	the	DET
ctmj-148	68	2	3d	3d	PROPN
ctmj-148	68	3	structures	structure	NOUN
ctmj-148	68	4	of	of	ADP
ctmj-148	68	5	the	the	DET
ctmj-148	68	6	proteins	protein	NOUN
ctmj-148	68	7	were	be	AUX
ctmj-148	68	8	downloaded	download	VERB
ctmj-148	68	9	from	from	ADP
ctmj-148	68	10	rcsb	rcsb	NOUN
ctmj-148	68	11	pdb	pdb	PROPN
ctmj-148	68	12	.	.	PUNCT
ctmj-148	69	1	in	in	ADP
ctmj-148	69	2	addition	addition	NOUN
ctmj-148	69	3	,	,	PUNCT
ctmj-148	69	4	homology	homology	NOUN
ctmj-148	69	5	modeling	modeling	NOUN
ctmj-148	69	6	was	be	AUX
ctmj-148	69	7	conducted	conduct	VERB
ctmj-148	69	8	for	for	ADP
ctmj-148	69	9	proteinstructures	proteinstructure	NOUN
ctmj-148	69	10	that	that	PRON
ctmj-148	69	11	were	be	AUX
ctmj-148	69	12	not	not	PART
ctmj-148	69	13	found	find	VERB
ctmj-148	69	14	in	in	ADP
ctmj-148	69	15	the	the	DET
ctmj-148	69	16	database	database	NOUN
ctmj-148	69	17	.	.	PUNCT
ctmj-148	70	1	the	the	DET
ctmj-148	70	2	http://www.chemspider.com/	http://www.chemspider.com/	NOUN
ctmj-148	70	3	https://www.ncbi.nlm.nih.gov/	https://www.ncbi.nlm.nih.gov/	PUNCT
ctmj-148	70	4	https://sso.cas.org/	https://sso.cas.org/	PROPN
ctmj-148	70	5	https://db.idrblab.org/ttd/	https://db.idrblab.org/ttd/	ADJ
ctmj-148	70	6	https://www.drugbank.ca/	https://www.drugbank.ca/	NUM
ctmj-148	70	7	http://www.uniprot.org/	http://www.uniprot.org/	NOUN
ctmj-148	70	8	http://www.rcsb.org/	http://www.rcsb.org/	NOUN
ctmj-148	70	9	×	×	PROPN
ctmj-148	70	10	×	×	NOUN
ctmj-148	70	11	3d	3d	NUM
ctmj-148	70	12	structure	structure	NOUN
ctmj-148	70	13	of	of	ADP
ctmj-148	70	14	c	c	NOUN
ctmj-148	70	15	-	-	PUNCT
ctmj-148	70	16	kit	kit	NOUN
ctmj-148	70	17	was	be	AUX
ctmj-148	70	18	downloaded	download	VERB
ctmj-148	70	19	from	from	ADP
ctmj-148	70	20	the	the	DET
ctmj-148	70	21	rcsb	rcsb	NOUN
ctmj-148	70	22	pdb	pdb	PROPN
ctmj-148	70	23	(	(	PUNCT
ctmj-148	70	24	pdb	pdb	PROPN
ctmj-148	70	25	i	i	PROPN
ctmj-148	70	26	d	d	PROPN
ctmj-148	70	27	:	:	PUNCT
ctmj-148	70	28	6gqk),21	6gqk),21	NUM
ctmj-148	70	29	and	and	CCONJ
ctmj-148	70	30	those	those	PRON
ctmj-148	70	31	of	of	ADP
ctmj-148	70	32	5	5	NUM
ctmj-148	70	33	-	-	PUNCT
ctmj-148	70	34	ht4	ht4	NOUN
ctmj-148	70	35	and	and	CCONJ
ctmj-148	70	36	aqp3	aqp3	PROPN
ctmj-148	70	37	were	be	AUX
ctmj-148	70	38	obtained	obtain	VERB
ctmj-148	70	39	by	by	ADP
ctmj-148	70	40	homology	homology	NOUN
ctmj-148	70	41	modeling	modeling	NOUN
ctmj-148	70	42	.	.	PUNCT
ctmj-148	71	1	the	the	DET
ctmj-148	71	2	glide	glide	NOUN
ctmj-148	71	3	module	module	NOUN
ctmj-148	71	4	in	in	ADP
ctmj-148	71	5	schro€dinger	schro€dinger	NOUN
ctmj-148	71	6	v2015.09	v2015.09	PROPN
ctmj-148	71	7	was	be	AUX
ctmj-148	71	8	used	use	VERB
ctmj-148	71	9	for	for	ADP
ctmj-148	71	10	mo	mo	PROPN
ctmj-148	71	11	lecular	lecular	ADJ
ctmj-148	71	12	docking	docking	NOUN
ctmj-148	71	13	modeling	modeling	NOUN
ctmj-148	71	14	and	and	CCONJ
ctmj-148	71	15	to	to	PART
ctmj-148	71	16	predict	predict	VERB
ctmj-148	71	17	the	the	DET
ctmj-148	71	18	binding	bind	VERB
ctmj-148	71	19	affinity	affinity	NOUN
ctmj-148	71	20	of	of	ADP
ctmj-148	71	21	ligands	ligand	NOUN
ctmj-148	71	22	for	for	ADP
ctmj-148	71	23	target	target	NOUN
ctmj-148	71	24	proteins	protein	NOUN
ctmj-148	71	25	.	.	PUNCT
ctmj-148	72	1	the	the	DET
ctmj-148	72	2	structures	structure	NOUN
ctmj-148	72	3	of	of	ADP
ctmj-148	72	4	the	the	DET
ctmj-148	72	5	proteins	protein	NOUN
ctmj-148	72	6	were	be	AUX
ctmj-148	72	7	manipulated	manipulate	VERB
ctmj-148	72	8	using	use	VERB
ctmj-148	72	9	the	the	DET
ctmj-148	72	10	“	"	PUNCT
ctmj-148	72	11	protein	protein	NOUN
ctmj-148	72	12	preparation	preparation	NOUN
ctmj-148	72	13	wizard	wizard	NOUN
ctmj-148	72	14	”	"	PUNCT
ctmj-148	72	15	workflow	workflow	NOUN
ctmj-148	72	16	in	in	ADP
ctmj-148	72	17	maestro	maestro	NOUN
ctmj-148	72	18	.	.	PUNCT
ctmj-148	73	1	the	the	DET
ctmj-148	73	2	main	main	ADJ
ctmj-148	73	3	operations	operation	NOUN
ctmj-148	73	4	were	be	AUX
ctmj-148	73	5	exclusion	exclusion	NOUN
ctmj-148	73	6	of	of	ADP
ctmj-148	73	7	water	water	NOUN
ctmj-148	73	8	molecules	molecule	NOUN
ctmj-148	73	9	,	,	PUNCT
ctmj-148	73	10	protonation	protonation	NOUN
ctmj-148	73	11	,	,	PUNCT
ctmj-148	73	12	and	and	CCONJ
ctmj-148	73	13	optimization	optimization	NOUN
ctmj-148	73	14	via	via	ADP
ctmj-148	73	15	opls_2005	opls_2005	PROPN
ctmj-148	73	16	force	force	NOUN
ctmj-148	73	17	field	field	NOUN
ctmj-148	73	18	.	.	PUNCT
ctmj-148	74	1	the	the	DET
ctmj-148	74	2	glide	glide	NOUN
ctmj-148	74	3	module	module	NOUN
ctmj-148	74	4	was	be	AUX
ctmj-148	74	5	used	use	VERB
ctmj-148	74	6	to	to	PART
ctmj-148	74	7	generate	generate	VERB
ctmj-148	74	8	a	a	DET
ctmj-148	74	9	grid	grid	NOUN
ctmj-148	74	10	file	file	NOUN
ctmj-148	74	11	for	for	ADP
ctmj-148	74	12	each	each	DET
ctmj-148	74	13	protein	protein	NOUN
ctmj-148	74	14	receptor	receptor	NOUN
ctmj-148	74	15	,	,	PUNCT
ctmj-148	74	16	to	to	PART
ctmj-148	74	17	determine	determine	VERB
ctmj-148	74	18	the	the	DET
ctmj-148	74	19	location	location	NOUN
ctmj-148	74	20	of	of	ADP
ctmj-148	74	21	the	the	DET
ctmj-148	74	22	active	active	ADJ
ctmj-148	74	23	site	site	NOUN
ctmj-148	74	24	of	of	ADP
ctmj-148	74	25	the	the	DET
ctmj-148	74	26	protein	protein	NOUN
ctmj-148	74	27	,	,	PUNCT
ctmj-148	74	28	in	in	ADP
ctmj-148	74	29	order	order	NOUN
ctmj-148	74	30	to	to	PART
ctmj-148	74	31	model	model	VERB
ctmj-148	74	32	the	the	DET
ctmj-148	74	33	binding	binding	NOUN
ctmj-148	74	34	of	of	ADP
ctmj-148	74	35	ligands	ligand	NOUN
ctmj-148	74	36	and	and	CCONJ
ctmj-148	74	37	proteins	protein	NOUN
ctmj-148	74	38	.	.	PUNCT
ctmj-148	75	1	the	the	DET
ctmj-148	75	2	grid	grid	NOUN
ctmj-148	75	3	enclosed	enclose	VERB
ctmj-148	75	4	a	a	DET
ctmj-148	75	5	box	box	NOUN
ctmj-148	75	6	centered	center	VERB
ctmj-148	75	7	on	on	ADP
ctmj-148	75	8	the	the	DET
ctmj-148	75	9	binding	bind	VERB
ctmj-148	75	10	site	site	NOUN
ctmj-148	75	11	with	with	ADP
ctmj-148	75	12	dimensions	dimension	NOUN
ctmj-148	75	13	of	of	ADP
ctmj-148	75	14	10	10	NUM
ctmj-148	75	15	10	10	NUM
ctmj-148	75	16	10	10	NUM
ctmj-148	75	17	å	å	NOUN
ctmj-148	75	18	.	.	PUNCT
ctmj-148	76	1	a	a	DET
ctmj-148	76	2	scaling	scale	VERB
ctmj-148	76	3	factor	factor	NOUN
ctmj-148	76	4	of	of	ADP
ctmj-148	76	5	0.8	0.8	NUM
ctmj-148	76	6	was	be	AUX
ctmj-148	76	7	used	use	VERB
ctmj-148	76	8	for	for	ADP
ctmj-148	76	9	the	the	DET
ctmj-148	76	10	van	van	PROPN
ctmj-148	76	11	der	der	NOUN
ctmj-148	76	12	waals	waal	NOUN
ctmj-148	76	13	radii	radius	NOUN
ctmj-148	76	14	of	of	ADP
ctmj-148	76	15	receptor	receptor	NOUN
ctmj-148	76	16	atoms	atom	NOUN
ctmj-148	76	17	with	with	ADP
ctmj-148	76	18	a	a	DET
ctmj-148	76	19	partial	partial	ADJ
ctmj-148	76	20	atomic	atomic	ADJ
ctmj-148	76	21	charge	charge	NOUN
ctmj-148	76	22	of	of	ADP
ctmj-148	76	23	<	<	PROPN
ctmj-148	76	24	0.15	0.15	NUM
ctmj-148	76	25	.	.	PUNCT
ctmj-148	77	1	an	an	DET
ctmj-148	77	2	extra	extra	ADJ
ctmj-148	77	3	-	-	ADJ
ctmj-148	77	4	precise	precise	ADJ
ctmj-148	77	5	glide	glide	ADJ
ctmj-148	77	6	docking	docking	NOUN
ctmj-148	77	7	procedure	procedure	NOUN
ctmj-148	77	8	(	(	PUNCT
ctmj-148	77	9	glide	glide	NOUN
ctmj-148	77	10	-	-	PUNCT
ctmj-148	77	11	xp	xp	NOUN
ctmj-148	77	12	)	)	PUNCT
ctmj-148	77	13	was	be	AUX
ctmj-148	77	14	employed	employ	VERB
ctmj-148	77	15	to	to	PART
ctmj-148	77	16	model	model	VERB
ctmj-148	77	17	the	the	DET
ctmj-148	77	18	docking	docking	NOUN
ctmj-148	77	19	of	of	ADP
ctmj-148	77	20	the	the	DET
ctmj-148	77	21	compounds	compound	NOUN
ctmj-148	77	22	to	to	ADP
ctmj-148	77	23	the	the	DET
ctmj-148	77	24	binding	bind	VERB
ctmj-148	77	25	sites	site	NOUN
ctmj-148	77	26	of	of	ADP
ctmj-148	77	27	the	the	DET
ctmj-148	77	28	proteins	protein	NOUN
ctmj-148	77	29	and	and	CCONJ
ctmj-148	77	30	the	the	DET
ctmj-148	77	31	optimal	optimal	ADJ
ctmj-148	77	32	orientation	orientation	NOUN
ctmj-148	77	33	of	of	ADP
ctmj-148	77	34	the	the	DET
ctmj-148	77	35	compound	compound	NOUN
ctmj-148	77	36	,	,	PUNCT
ctmj-148	77	37	determined	determine	VERB
ctmj-148	77	38	using	use	VERB
ctmj-148	77	39	the	the	DET
ctmj-148	77	40	glide	glide	NOUN
ctmj-148	77	41	scoring	scoring	NOUN
ctmj-148	77	42	function	function	NOUN
ctmj-148	77	43	(	(	PUNCT
ctmj-148	77	44	g	g	NOUN
ctmj-148	77	45	-	-	PUNCT
ctmj-148	77	46	score	score	NOUN
ctmj-148	77	47	)	)	PUNCT
ctmj-148	77	48	,	,	PUNCT
ctmj-148	77	49	was	be	AUX
ctmj-148	77	50	recorded	record	VERB
ctmj-148	77	51	.	.	PUNCT
ctmj-148	78	1	the	the	DET
ctmj-148	78	2	more	more	ADV
ctmj-148	78	3	negative	negative	ADJ
ctmj-148	78	4	the	the	DET
ctmj-148	78	5	g	g	NOUN
ctmj-148	78	6	-	-	PUNCT
ctmj-148	78	7	score	score	NOUN
ctmj-148	78	8	is	be	AUX
ctmj-148	78	9	,	,	PUNCT
ctmj-148	78	10	the	the	DET
ctmj-148	78	11	stronger	strong	ADJ
ctmj-148	78	12	is	be	AUX
ctmj-148	78	13	the	the	DET
ctmj-148	78	14	expected	expect	VERB
ctmj-148	78	15	binding	bind	VERB
ctmj-148	78	16	affinity	affinity	NOUN
ctmj-148	78	17	of	of	ADP
ctmj-148	78	18	the	the	DET
ctmj-148	78	19	compound	compound	NOUN
ctmj-148	78	20	and	and	CCONJ
ctmj-148	78	21	receptor	receptor	NOUN
ctmj-148	78	22	.	.	PUNCT
ctmj-148	79	1	molecular	molecular	ADJ
ctmj-148	79	2	graphics	graphic	NOUN
ctmj-148	79	3	were	be	AUX
ctmj-148	79	4	generated	generate	VERB
ctmj-148	79	5	using	use	VERB
ctmj-148	79	6	pymol	pymol	PROPN
ctmj-148	79	7	(	(	PUNCT
ctmj-148	79	8	https://www.pymol.org/	https://www.pymol.org/	NOUN
ctmj-148	79	9	)	)	PUNCT
ctmj-148	79	10	.	.	PUNCT
ctmj-148	80	1	western	western	ADJ
ctmj-148	80	2	blotting	blotting	ADJ
ctmj-148	80	3	protein	protein	NOUN
ctmj-148	80	4	lysates	lysate	NOUN
ctmj-148	80	5	of	of	ADP
ctmj-148	80	6	colonic	colonic	ADJ
ctmj-148	80	7	tissue	tissue	NOUN
ctmj-148	80	8	were	be	AUX
ctmj-148	80	9	prepared	prepare	VERB
ctmj-148	80	10	using	use	VERB
ctmj-148	80	11	ripa	ripa	ADJ
ctmj-148	80	12	lysis	lysis	NOUN
ctmj-148	80	13	buffer	buffer	NOUN
ctmj-148	80	14	(	(	PUNCT
ctmj-148	80	15	solarbio	solarbio	NOUN
ctmj-148	80	16	,	,	PUNCT
ctmj-148	80	17	beijing	beijing	PROPN
ctmj-148	80	18	,	,	PUNCT
ctmj-148	80	19	china	china	PROPN
ctmj-148	80	20	)	)	PUNCT
ctmj-148	80	21	containing	contain	VERB
ctmj-148	80	22	protease	protease	NOUN
ctmj-148	80	23	inhibitors	inhibitor	NOUN
ctmj-148	80	24	.	.	PUNCT
ctmj-148	81	1	the	the	DET
ctmj-148	81	2	protein	protein	NOUN
ctmj-148	81	3	content	content	NOUN
ctmj-148	81	4	of	of	ADP
ctmj-148	81	5	each	each	PRON
ctmj-148	81	6	was	be	AUX
ctmj-148	81	7	quantified	quantify	VERB
ctmj-148	81	8	using	use	VERB
ctmj-148	81	9	the	the	DET
ctmj-148	81	10	bicinchoninic	bicinchoninic	ADJ
ctmj-148	81	11	acid	acid	NOUN
ctmj-148	81	12	method	method	NOUN
ctmj-148	81	13	(	(	PUNCT
ctmj-148	81	14	beyotime	beyotime	NOUN
ctmj-148	81	15	,	,	PUNCT
ctmj-148	81	16	shanghai	shanghai	PROPN
ctmj-148	81	17	,	,	PUNCT
ctmj-148	81	18	china	china	PROPN
ctmj-148	81	19	)	)	PUNCT
ctmj-148	81	20	,	,	PUNCT
ctmj-148	81	21	then	then	ADV
ctmj-148	81	22	the	the	DET
ctmj-148	81	23	samples	sample	NOUN
ctmj-148	81	24	were	be	AUX
ctmj-148	81	25	separated	separate	VERB
ctmj-148	81	26	by	by	ADP
ctmj-148	81	27	sodium	sodium	NOUN
ctmj-148	81	28	dodecyl	dodecyl	PROPN
ctmj-148	81	29	sulfate	sulfate	NOUN
ctmj-148	81	30	-	-	PUNCT
ctmj-148	81	31	polyacrylamide	polyacrylamide	NOUN
ctmj-148	81	32	gel	gel	NOUN
ctmj-148	81	33	electro	electro	PROPN
ctmj-148	81	34	phoresis	phoresis	NOUN
ctmj-148	81	35	on	on	ADP
ctmj-148	81	36	10	10	NUM
ctmj-148	81	37	%	%	NOUN
ctmj-148	81	38	polyacrylamide	polyacrylamide	NOUN
ctmj-148	81	39	gels	gel	NOUN
ctmj-148	81	40	,	,	PUNCT
ctmj-148	81	41	and	and	CCONJ
ctmj-148	81	42	transferred	transfer	VERB
ctmj-148	81	43	to	to	ADP
ctmj-148	81	44	polyvinylidene	polyvinylidene	NOUN
ctmj-148	81	45	fluoride	fluoride	NOUN
ctmj-148	81	46	membranes	membrane	NOUN
ctmj-148	81	47	(	(	PUNCT
ctmj-148	81	48	millipore	millipore	PROPN
ctmj-148	81	49	,	,	PUNCT
ctmj-148	81	50	billerica	billerica	PROPN
ctmj-148	81	51	,	,	PUNCT
ctmj-148	81	52	ma	ma	PROPN
ctmj-148	81	53	)	)	PUNCT
ctmj-148	81	54	.	.	PUNCT
ctmj-148	82	1	the	the	DET
ctmj-148	82	2	membranes	membrane	NOUN
ctmj-148	82	3	were	be	AUX
ctmj-148	82	4	then	then	ADV
ctmj-148	82	5	blocked	block	VERB
ctmj-148	82	6	with	with	ADP
ctmj-148	82	7	5	5	NUM
ctmj-148	82	8	%	%	NOUN
ctmj-148	82	9	skimmed	skim	VERB
ctmj-148	82	10	milk	milk	NOUN
ctmj-148	82	11	powder	powder	NOUN
ctmj-148	82	12	(	(	PUNCT
ctmj-148	82	13	bioruler	bioruler	NOUN
ctmj-148	82	14	,	,	PUNCT
ctmj-148	82	15	danbury	danbury	PROPN
ctmj-148	82	16	,	,	PUNCT
ctmj-148	82	17	ct	ct	PROPN
ctmj-148	82	18	)	)	PUNCT
ctmj-148	82	19	in	in	ADP
ctmj-148	82	20	tris	tris	ADJ
ctmj-148	82	21	-	-	PUNCT
ctmj-148	82	22	buffered	buffer	VERB
ctmj-148	82	23	saline	saline	NOUN
ctmj-148	82	24	for	for	ADP
ctmj-148	82	25	2	2	NUM
ctmj-148	82	26	h	h	NOUN
ctmj-148	82	27	,	,	PUNCT
ctmj-148	82	28	and	and	CCONJ
ctmj-148	82	29	incubated	incubate	VERB
ctmj-148	82	30	overnight	overnight	ADV
ctmj-148	82	31	with	with	ADP
ctmj-148	82	32	primary	primary	ADJ
ctmj-148	82	33	antibodies	antibody	NOUN
ctmj-148	82	34	targeting	target	VERB
ctmj-148	82	35	c	c	NOUN
ctmj-148	82	36	-	-	PUNCT
ctmj-148	82	37	kit	kit	NOUN
ctmj-148	82	38	(	(	PUNCT
ctmj-148	82	39	sc-365504	sc-365504	NOUN
ctmj-148	82	40	,	,	PUNCT
ctmj-148	82	41	1:100	1:100	NUM
ctmj-148	82	42	;	;	PUNCT
ctmj-148	82	43	santa	santa	PROPN
ctmj-148	82	44	cruz	cruz	PROPN
ctmj-148	82	45	,	,	PUNCT
ctmj-148	82	46	san	san	PROPN
ctmj-148	82	47	francisco	francisco	PROPN
ctmj-148	82	48	,	,	PUNCT
ctmj-148	82	49	ca	ca	NOUN
ctmj-148	82	50	)	)	PUNCT
ctmj-148	82	51	,	,	PUNCT
ctmj-148	82	52	5	5	NUM
ctmj-148	82	53	-	-	PUNCT
ctmj-148	82	54	ht4	ht4	NOUN
ctmj-148	82	55	(	(	PUNCT
ctmj-148	82	56	ta323344	ta323344	PROPN
ctmj-148	82	57	,	,	PUNCT
ctmj-148	82	58	1:200	1:200	NUM
ctmj-148	82	59	;	;	PUNCT
ctmj-148	82	60	origene	origene	NOUN
ctmj-148	82	61	,	,	PUNCT
ctmj-148	82	62	rockville	rockville	PROPN
ctmj-148	82	63	,	,	PUNCT
ctmj-148	82	64	md	md	PROPN
ctmj-148	82	65	)	)	PUNCT
ctmj-148	82	66	,	,	PUNCT
ctmj-148	82	67	aq3	aq3	NOUN
ctmj-148	82	68	(	(	PUNCT
ctmj-148	82	69	ab125219	ab125219	PROPN
ctmj-148	82	70	,	,	PUNCT
ctmj-148	82	71	1:1000	1:1000	NUM
ctmj-148	82	72	;	;	PUNCT
ctmj-148	82	73	abcam	abcam	PROPN
ctmj-148	82	74	,	,	PUNCT
ctmj-148	82	75	cambridge	cambridge	PROPN
ctmj-148	82	76	,	,	PUNCT
ctmj-148	82	77	uk	uk	PROPN
ctmj-148	82	78	)	)	PUNCT
ctmj-148	82	79	,	,	PUNCT
ctmj-148	82	80	or	or	CCONJ
ctmj-148	82	81	glyceraldehyde	glyceraldehyde	PROPN
ctmj-148	82	82	3	3	NUM
ctmj-148	82	83	-	-	PUNCT
ctmj-148	82	84	phosphate	phosphate	NOUN
ctmj-148	82	85	dehydrogenase	dehydrogenase	NOUN
ctmj-148	82	86	(	(	PUNCT
ctmj-148	82	87	gapdh	gapdh	NOUN
ctmj-148	82	88	;	;	PUNCT
ctmj-148	82	89	1:20	1:20	NUM
ctmj-148	82	90	000	000	NUM
ctmj-148	82	91	;	;	PUNCT
ctmj-148	82	92	proteintech	proteintech	NOUN
ctmj-148	82	93	,	,	PUNCT
ctmj-148	82	94	chicago	chicago	PROPN
ctmj-148	82	95	,	,	PUNCT
ctmj-148	82	96	il	il	PROPN
ctmj-148	82	97	)	)	PUNCT
ctmj-148	82	98	at	at	ADP
ctmj-148	82	99	4	4	NUM
ctmj-148	82	100	◦	◦	NOUN
ctmj-148	82	101	c.	c.	NOUN
ctmj-148	82	102	the	the	DET
ctmj-148	82	103	membranes	membrane	NOUN
ctmj-148	82	104	were	be	AUX
ctmj-148	82	105	then	then	ADV
ctmj-148	82	106	incubated	incubate	VERB
ctmj-148	82	107	with	with	ADP
ctmj-148	82	108	a	a	DET
ctmj-148	82	109	secondary	secondary	ADJ
ctmj-148	82	110	antibody	antibody	NOUN
ctmj-148	82	111	,	,	PUNCT
ctmj-148	82	112	after	after	ADP
ctmj-148	82	113	three	three	NUM
ctmj-148	82	114	washes	wash	NOUN
ctmj-148	82	115	.	.	PUNCT
ctmj-148	83	1	specific	specific	ADJ
ctmj-148	83	2	protein	protein	NOUN
ctmj-148	83	3	bands	band	NOUN
ctmj-148	83	4	were	be	AUX
ctmj-148	83	5	detected	detect	VERB
ctmj-148	83	6	using	use	VERB
ctmj-148	83	7	enhanced	enhanced	ADJ
ctmj-148	83	8	chemiluminescence	chemiluminescence	NOUN
ctmj-148	83	9	solution	solution	NOUN
ctmj-148	83	10	(	(	PUNCT
ctmj-148	83	11	proteintech	proteintech	NOUN
ctmj-148	83	12	)	)	PUNCT
ctmj-148	83	13	and	and	CCONJ
ctmj-148	83	14	imaged	image	VERB
ctmj-148	83	15	using	use	VERB
ctmj-148	83	16	a	a	DET
ctmj-148	83	17	chemidoc	chemidoc	ADJ
ctmj-148	83	18	mp	mp	NOUN
ctmj-148	83	19	imaging	imaging	NOUN
ctmj-148	83	20	system	system	NOUN
ctmj-148	83	21	(	(	PUNCT
ctmj-148	83	22	bio	bio	NOUN
ctmj-148	83	23	-	-	ADJ
ctmj-148	83	24	rad	rad	PROPN
ctmj-148	83	25	,	,	PUNCT
ctmj-148	83	26	hercules	hercule	NOUN
ctmj-148	83	27	,	,	PUNCT
ctmj-148	83	28	ca	ca	NOUN
ctmj-148	83	29	)	)	PUNCT
ctmj-148	83	30	.	.	PUNCT
ctmj-148	84	1	statistical	statistical	ADJ
ctmj-148	84	2	analysis	analysis	NOUN
ctmj-148	84	3	data	datum	NOUN
ctmj-148	84	4	are	be	AUX
ctmj-148	84	5	shown	show	VERB
ctmj-148	84	6	as	as	ADP
ctmj-148	84	7	means	mean	NOUN
ctmj-148	84	8	(	(	PUNCT
ctmj-148	84	9	sems	sem	NOUN
ctmj-148	84	10	)	)	PUNCT
ctmj-148	84	11	.	.	PUNCT
ctmj-148	85	1	student	student	NOUN
ctmj-148	85	2	’s	’s	PART
ctmj-148	85	3	t	t	PROPN
ctmj-148	85	4	-	-	PUNCT
ctmj-148	85	5	test	test	NOUN
ctmj-148	85	6	was	be	AUX
ctmj-148	85	7	used	use	VERB
ctmj-148	85	8	to	to	PART
ctmj-148	85	9	compare	compare	VERB
ctmj-148	85	10	data	datum	NOUN
ctmj-148	85	11	between	between	ADP
ctmj-148	85	12	the	the	DET
ctmj-148	85	13	two	two	NUM
ctmj-148	85	14	groups	group	NOUN
ctmj-148	85	15	.	.	PUNCT
ctmj-148	86	1	p	p	X
ctmj-148	86	2	<	<	X
ctmj-148	86	3	.05	.05	NUM
ctmj-148	86	4	was	be	AUX
ctmj-148	86	5	accepted	accept	VERB
ctmj-148	86	6	as	as	ADP
ctmj-148	86	7	indicating	indicate	VERB
ctmj-148	86	8	statistical	statistical	ADJ
ctmj-148	86	9	significance	significance	NOUN
ctmj-148	86	10	.	.	PUNCT
ctmj-148	87	1	data	datum	NOUN
ctmj-148	87	2	analysis	analysis	NOUN
ctmj-148	87	3	was	be	AUX
ctmj-148	87	4	performed	perform	VERB
ctmj-148	87	5	using	use	VERB
ctmj-148	87	6	graphpad	graphpad	NOUN
ctmj-148	87	7	prism	prism	NOUN
ctmj-148	87	8	8.0	8.0	NUM
ctmj-148	87	9	software	software	NOUN
ctmj-148	87	10	(	(	PUNCT
ctmj-148	87	11	www.graphpad.com	www.graphpad.com	X
ctmj-148	87	12	)	)	PUNCT
ctmj-148	87	13	.	.	PUNCT
ctmj-148	88	1	results	result	VERB
ctmj-148	88	2	laxative	laxative	ADJ
ctmj-148	88	3	effect	effect	NOUN
ctmj-148	88	4	of	of	ADP
ctmj-148	88	5	rhubarb	rhubarb	NOUN
ctmj-148	88	6	extract	extract	NOUN
ctmj-148	88	7	in	in	ADP
ctmj-148	88	8	constipated	constipate	VERB
ctmj-148	88	9	rats	rat	NOUN
ctmj-148	88	10	to	to	PART
ctmj-148	88	11	confirm	confirm	VERB
ctmj-148	88	12	the	the	DET
ctmj-148	88	13	laxative	laxative	ADJ
ctmj-148	88	14	effect	effect	NOUN
ctmj-148	88	15	of	of	ADP
ctmj-148	88	16	rhubarb	rhubarb	NOUN
ctmj-148	88	17	,	,	PUNCT
ctmj-148	88	18	we	we	PRON
ctmj-148	88	19	administered	administer	VERB
ctmj-148	88	20	rhubarb	rhubarb	NOUN
ctmj-148	88	21	extract	extract	NOUN
ctmj-148	88	22	to	to	ADP
ctmj-148	88	23	sprague	sprague	NOUN
ctmj-148	88	24	-	-	PUNCT
ctmj-148	88	25	dawley	dawley	NOUN
ctmj-148	88	26	rats	rat	NOUN
ctmj-148	88	27	in	in	ADP
ctmj-148	88	28	which	which	PRON
ctmj-148	88	29	constipation	constipation	NOUN
ctmj-148	88	30	had	have	AUX
ctmj-148	88	31	been	be	AUX
ctmj-148	88	32	induced	induce	VERB
ctmj-148	88	33	by	by	ADP
ctmj-148	88	34	loperamide	loperamide	NOUN
ctmj-148	88	35	gavage	gavage	NOUN
ctmj-148	88	36	for	for	ADP
ctmj-148	88	37	7	7	NUM
ctmj-148	88	38	days	day	NOUN
ctmj-148	88	39	.	.	PUNCT
ctmj-148	89	1	loperamide	loperamide	NOUN
ctmj-148	89	2	is	be	AUX
ctmj-148	89	3	commonly	commonly	ADV
ctmj-148	89	4	used	use	VERB
ctmj-148	89	5	to	to	PART
ctmj-148	89	6	increase	increase	VERB
ctmj-148	89	7	mucosal	mucosal	ADJ
ctmj-148	89	8	contact	contact	NOUN
ctmj-148	89	9	time	time	NOUN
ctmj-148	89	10	,	,	PUNCT
ctmj-148	89	11	which	which	PRON
ctmj-148	89	12	has	have	VERB
ctmj-148	89	13	the	the	DET
ctmj-148	89	14	effect	effect	NOUN
ctmj-148	89	15	of	of	ADP
ctmj-148	89	16	inducing	induce	VERB
ctmj-148	89	17	additional	additional	ADJ
ctmj-148	89	18	absorption	absorption	NOUN
ctmj-148	89	19	of	of	ADP
ctmj-148	89	20	electrolytes	electrolyte	NOUN
ctmj-148	89	21	and	and	CCONJ
ctmj-148	89	22	water	water	NOUN
ctmj-148	89	23	,	,	PUNCT
ctmj-148	89	24	thereby	thereby	ADV
ctmj-148	89	25	reducing	reduce	VERB
ctmj-148	89	26	fecal	fecal	ADJ
ctmj-148	89	27	mass	mass	NOUN
ctmj-148	89	28	and	and	CCONJ
ctmj-148	89	29	the	the	DET
ctmj-148	89	30	number	number	NOUN
ctmj-148	89	31	of	of	ADP
ctmj-148	89	32	bowel	bowel	NOUN
ctmj-148	89	33	movements	movement	NOUN
ctmj-148	89	34	.	.	PUNCT
ctmj-148	90	1	twenty	twenty	NUM
ctmj-148	90	2	-	-	PUNCT
ctmj-148	90	3	four	four	NUM
ctmj-148	90	4	-	-	PUNCT
ctmj-148	90	5	hour	hour	NOUN
ctmj-148	90	6	fecal	fecal	ADJ
ctmj-148	90	7	water	water	NOUN
ctmj-148	90	8	content	content	NOUN
ctmj-148	90	9	was	be	AUX
ctmj-148	90	10	monitored	monitor	VERB
ctmj-148	90	11	for	for	ADP
ctmj-148	90	12	the	the	DET
ctmj-148	90	13	first	first	ADJ
ctmj-148	90	14	6	6	NUM
ctmj-148	90	15	days	day	NOUN
ctmj-148	90	16	of	of	ADP
ctmj-148	90	17	loperamide	loperamide	NOUN
ctmj-148	90	18	administration	administration	NOUN
ctmj-148	90	19	,	,	PUNCT
ctmj-148	90	20	and	and	CCONJ
ctmj-148	90	21	a	a	DET
ctmj-148	90	22	reduction	reduction	NOUN
ctmj-148	90	23	was	be	AUX
ctmj-148	90	24	identified	identify	VERB
ctmj-148	90	25	in	in	ADP
ctmj-148	90	26	the	the	DET
ctmj-148	90	27	model	model	NOUN
ctmj-148	90	28	group	group	NOUN
ctmj-148	90	29	from	from	ADP
ctmj-148	90	30	the	the	DET
ctmj-148	90	31	second	second	ADJ
ctmj-148	90	32	day	day	NOUN
ctmj-148	90	33	(	(	PUNCT
ctmj-148	90	34	fig	fig	NOUN
ctmj-148	90	35	.	.	PUNCT
ctmj-148	91	1	1a	1a	NOUN
ctmj-148	91	2	)	)	PUNCT
ctmj-148	91	3	,	,	PUNCT
ctmj-148	91	4	which	which	PRON
ctmj-148	91	5	confirmed	confirm	VERB
ctmj-148	91	6	that	that	SCONJ
ctmj-148	91	7	constipation	constipation	NOUN
ctmj-148	91	8	had	have	AUX
ctmj-148	91	9	been	be	AUX
ctmj-148	91	10	successfully	successfully	ADV
ctmj-148	91	11	induced	induce	VERB
ctmj-148	91	12	.	.	PUNCT
ctmj-148	92	1	then	then	ADV
ctmj-148	92	2	,	,	PUNCT
ctmj-148	92	3	rhubarb	rhubarb	ADJ
ctmj-148	92	4	fig	fig	NOUN
ctmj-148	92	5	.	.	PUNCT
ctmj-148	93	1	1	1	X
ctmj-148	93	2	.	.	X
ctmj-148	93	3	laxative	laxative	ADJ
ctmj-148	93	4	effect	effect	NOUN
ctmj-148	93	5	of	of	ADP
ctmj-148	93	6	rhubarb	rhubarb	NOUN
ctmj-148	93	7	extract	extract	NOUN
ctmj-148	93	8	in	in	ADP
ctmj-148	93	9	constipated	constipate	VERB
ctmj-148	93	10	rats	rat	NOUN
ctmj-148	93	11	(	(	PUNCT
ctmj-148	93	12	a	a	X
ctmj-148	93	13	)	)	PUNCT
ctmj-148	93	14	the	the	DET
ctmj-148	93	15	24	24	NUM
ctmj-148	93	16	-	-	PUNCT
ctmj-148	93	17	h	h	NOUN
ctmj-148	93	18	fecal	fecal	ADJ
ctmj-148	93	19	water	water	NOUN
ctmj-148	93	20	content	content	NOUN
ctmj-148	93	21	of	of	ADP
ctmj-148	93	22	the	the	DET
ctmj-148	93	23	control	control	NOUN
ctmj-148	93	24	and	and	CCONJ
ctmj-148	93	25	model	model	NOUN
ctmj-148	93	26	groups	group	NOUN
ctmj-148	93	27	(	(	PUNCT
ctmj-148	93	28	b	b	X
ctmj-148	93	29	)	)	PUNCT
ctmj-148	93	30	the	the	DET
ctmj-148	93	31	evacuation	evacuation	NOUN
ctmj-148	93	32	indices	index	NOUN
ctmj-148	93	33	of	of	ADP
ctmj-148	93	34	the	the	DET
ctmj-148	93	35	three	three	NUM
ctmj-148	93	36	groups	group	NOUN
ctmj-148	93	37	(	(	PUNCT
ctmj-148	93	38	c	c	NOUN
ctmj-148	93	39	)	)	PUNCT
ctmj-148	93	40	https://www.pymol.org/	https://www.pymol.org/	NOUN
ctmj-148	93	41	http://www.graphpad.com/	http://www.graphpad.com/	PROPN
ctmj-148	93	42	ctmj	ctmj	PROPN
ctmj-148	94	1	|	|	ADV
ctmj-148	94	2	traditionalmedicinejournals.com	traditionalmedicinejournals.com	X
ctmj-148	94	3	issn	issn	PROPN
ctmj-148	94	4	:	:	PUNCT
ctmj-148	94	5	2693	2693	NUM
ctmj-148	94	6	6356	6356	NUM
ctmj-148	94	7	2024	2024	NUM
ctmj-148	94	8	|	|	ADV
ctmj-148	94	9	vol	vol	NOUN
ctmj-148	94	10	7	7	NUM
ctmj-148	94	11	|	|	NOUN
ctmj-148	94	12	issue	issue	VERB
ctmj-148	94	13	1	1	NUM
ctmj-148	95	1	the	the	DET
ctmj-148	95	2	contents	content	NOUN
ctmj-148	95	3	of	of	ADP
ctmj-148	95	4	the	the	DET
ctmj-148	95	5	colorectum	colorectum	NOUN
ctmj-148	95	6	and	and	CCONJ
ctmj-148	95	7	the	the	DET
ctmj-148	95	8	shape	shape	NOUN
ctmj-148	95	9	of	of	ADP
ctmj-148	95	10	the	the	DET
ctmj-148	95	11	feces	fece	NOUN
ctmj-148	95	12	.	.	PUNCT
ctmj-148	96	1	note	note	NOUN
ctmj-148	96	2	:	:	PUNCT
ctmj-148	96	3	data	datum	NOUN
ctmj-148	96	4	are	be	AUX
ctmj-148	96	5	presented	present	VERB
ctmj-148	96	6	as	as	ADP
ctmj-148	96	7	the	the	DET
ctmj-148	96	8	mean	mean	NOUN
ctmj-148	96	9	(	(	PUNCT
ctmj-148	96	10	sem	sem	NOUN
ctmj-148	96	11	)	)	PUNCT
ctmj-148	96	12	.	.	PUNCT
ctmj-148	97	1	n	n	PRON
ctmj-148	97	2	¼	¼	NOUN
ctmj-148	97	3	10	10	NUM
ctmj-148	97	4	.	.	PUNCT
ctmj-148	98	1	*	*	PUNCT
ctmj-148	98	2	*	*	PUNCT
ctmj-148	98	3	p	p	X
ctmj-148	98	4	<	<	X
ctmj-148	98	5	.01	.01	NUM
ctmj-148	98	6	vs.	vs.	ADP
ctmj-148	98	7	the	the	DET
ctmj-148	98	8	control	control	NOUN
ctmj-148	98	9	group	group	NOUN
ctmj-148	98	10	.	.	PUNCT
ctmj-148	99	1	extract	extract	NOUN
ctmj-148	99	2	was	be	AUX
ctmj-148	99	3	administered	administer	VERB
ctmj-148	99	4	to	to	ADP
ctmj-148	99	5	the	the	DET
ctmj-148	99	6	treatment	treatment	NOUN
ctmj-148	99	7	group	group	NOUN
ctmj-148	99	8	for	for	ADP
ctmj-148	99	9	3	3	NUM
ctmj-148	99	10	days	day	NOUN
ctmj-148	99	11	.	.	PUNCT
ctmj-148	100	1	a	a	DET
ctmj-148	100	2	significant	significant	ADJ
ctmj-148	100	3	increase	increase	NOUN
ctmj-148	100	4	in	in	ADP
ctmj-148	100	5	ei	ei	NOUN
ctmj-148	100	6	occurred	occur	VERB
ctmj-148	100	7	in	in	ADP
ctmj-148	100	8	this	this	DET
ctmj-148	100	9	group	group	NOUN
ctmj-148	100	10	(	(	PUNCT
ctmj-148	100	11	fig	fig	NOUN
ctmj-148	100	12	.	.	PUNCT
ctmj-148	101	1	1b	1b	NUM
ctmj-148	101	2	)	)	PUNCT
ctmj-148	101	3	,	,	PUNCT
ctmj-148	102	1	which	which	PRON
ctmj-148	102	2	confirmed	confirm	VERB
ctmj-148	102	3	that	that	SCONJ
ctmj-148	102	4	rhubarb	rhubarb	NOUN
ctmj-148	102	5	extract	extract	NOUN
ctmj-148	102	6	has	have	VERB
ctmj-148	102	7	a	a	DET
ctmj-148	102	8	laxative	laxative	ADJ
ctmj-148	102	9	effect	effect	NOUN
ctmj-148	102	10	in	in	ADP
ctmj-148	102	11	constipated	constipate	VERB
ctmj-148	102	12	rats	rat	NOUN
ctmj-148	103	1	.	.	PUNCT
ctmj-148	104	1	we	we	PRON
ctmj-148	104	2	then	then	ADV
ctmj-148	104	3	compared	compare	VERB
ctmj-148	104	4	the	the	DET
ctmj-148	104	5	water	water	NOUN
ctmj-148	104	6	content	content	NOUN
ctmj-148	104	7	of	of	ADP
ctmj-148	104	8	the	the	DET
ctmj-148	104	9	colorectal	colorectal	ADJ
ctmj-148	104	10	contents	content	NOUN
ctmj-148	104	11	of	of	ADP
ctmj-148	104	12	the	the	DET
ctmj-148	104	13	control	control	NOUN
ctmj-148	104	14	,	,	PUNCT
ctmj-148	104	15	model	model	NOUN
ctmj-148	104	16	,	,	PUNCT
ctmj-148	104	17	and	and	CCONJ
ctmj-148	104	18	treatment	treatment	NOUN
ctmj-148	104	19	groups	group	NOUN
ctmj-148	104	20	(	(	PUNCT
ctmj-148	104	21	fig	fig	NOUN
ctmj-148	104	22	.	.	PUNCT
ctmj-148	104	23	1c	1c	NOUN
ctmj-148	104	24	)	)	PUNCT
ctmj-148	104	25	and	and	CCONJ
ctmj-148	104	26	found	find	VERB
ctmj-148	104	27	that	that	SCONJ
ctmj-148	104	28	the	the	DET
ctmj-148	104	29	rhubarb	rhubarb	NOUN
ctmj-148	104	30	extract	extract	NOUN
ctmj-148	104	31	increased	increase	VERB
ctmj-148	104	32	this	this	PRON
ctmj-148	104	33	.	.	PUNCT
ctmj-148	105	1	these	these	DET
ctmj-148	105	2	results	result	NOUN
ctmj-148	105	3	imply	imply	VERB
ctmj-148	105	4	that	that	SCONJ
ctmj-148	105	5	rhubarb	rhubarb	NOUN
ctmj-148	105	6	may	may	AUX
ctmj-148	105	7	have	have	VERB
ctmj-148	105	8	its	its	PRON
ctmj-148	105	9	laxative	laxative	ADJ
ctmj-148	105	10	effect	effect	NOUN
ctmj-148	105	11	by	by	ADP
ctmj-148	105	12	increasing	increase	VERB
ctmj-148	105	13	the	the	DET
ctmj-148	105	14	retention	retention	NOUN
ctmj-148	105	15	of	of	ADP
ctmj-148	105	16	water	water	NOUN
ctmj-148	105	17	in	in	ADP
ctmj-148	105	18	the	the	DET
ctmj-148	105	19	colorectum	colorectum	NOUN
ctmj-148	105	20	.	.	PUNCT
ctmj-148	106	1	identification	identification	NOUN
ctmj-148	106	2	of	of	ADP
ctmj-148	106	3	rhubarb	rhubarb	ADJ
ctmj-148	106	4	derivatives	derivative	NOUN
ctmj-148	106	5	in	in	ADP
ctmj-148	106	6	rat	rat	NOUN
ctmj-148	106	7	feces	fece	NOUN
ctmj-148	106	8	we	we	PRON
ctmj-148	106	9	used	use	VERB
ctmj-148	106	10	hplc	hplc	PROPN
ctmj-148	106	11	-	-	PUNCT
ctmj-148	106	12	ltq	ltq	NOUN
ctmj-148	106	13	-	-	PUNCT
ctmj-148	106	14	orbitrap	orbitrap	NOUN
ctmj-148	106	15	ms	ms	NOUN
ctmj-148	106	16	to	to	PART
ctmj-148	106	17	identify	identify	VERB
ctmj-148	106	18	the	the	DET
ctmj-148	106	19	derivatives	derivative	NOUN
ctmj-148	106	20	of	of	ADP
ctmj-148	106	21	rhubarb	rhubarb	NOUN
ctmj-148	106	22	in	in	ADP
ctmj-148	106	23	the	the	DET
ctmj-148	106	24	colorectum	colorectum	NOUN
ctmj-148	106	25	that	that	PRON
ctmj-148	106	26	might	might	AUX
ctmj-148	106	27	contribute	contribute	VERB
ctmj-148	106	28	to	to	ADP
ctmj-148	106	29	its	its	PRON
ctmj-148	106	30	laxative	laxative	ADJ
ctmj-148	106	31	effect	effect	NOUN
ctmj-148	106	32	.	.	PUNCT
ctmj-148	107	1	using	use	VERB
ctmj-148	107	2	the	the	DET
ctmj-148	107	3	established	establish	VERB
ctmj-148	107	4	strategy	strategy	NOUN
ctmj-148	107	5	of	of	ADP
ctmj-148	107	6	characteristic	characteristic	ADJ
ctmj-148	107	7	fragment	fragment	NOUN
ctmj-148	107	8	filtration	filtration	NOUN
ctmj-148	107	9	for	for	ADP
ctmj-148	107	10	the	the	DET
ctmj-148	107	11	detection	detection	NOUN
ctmj-148	107	12	of	of	ADP
ctmj-148	107	13	rhubarb	rhubarb	NOUN
ctmj-148	107	14	derivatives,19,22	derivatives,19,22	NOUN
ctmj-148	107	15	a	a	DET
ctmj-148	107	16	series	series	NOUN
ctmj-148	107	17	of	of	ADP
ctmj-148	107	18	anthraquinones	anthraquinone	NOUN
ctmj-148	107	19	and	and	CCONJ
ctmj-148	107	20	anthrones	anthrone	NOUN
ctmj-148	107	21	were	be	AUX
ctmj-148	107	22	identified	identify	VERB
ctmj-148	107	23	.	.	PUNCT
ctmj-148	108	1	the	the	DET
ctmj-148	108	2	identification	identification	NOUN
ctmj-148	108	3	process	process	NOUN
ctmj-148	108	4	can	can	AUX
ctmj-148	108	5	be	be	AUX
ctmj-148	108	6	illustrated	illustrate	VERB
ctmj-148	108	7	using	use	VERB
ctmj-148	108	8	the	the	DET
ctmj-148	108	9	example	example	NOUN
ctmj-148	108	10	of	of	ADP
ctmj-148	108	11	the	the	DET
ctmj-148	108	12	metabolite	metabolite	NOUN
ctmj-148	108	13	emodin	emodin	NOUN
ctmj-148	108	14	-	-	PUNCT
ctmj-148	108	15	oglucuronide	oglucuronide	NOUN
ctmj-148	108	16	(	(	PUNCT
ctmj-148	108	17	fig	fig	NOUN
ctmj-148	108	18	.	.	PUNCT
ctmj-148	109	1	2	2	NUM
ctmj-148	109	2	)	)	PUNCT
ctmj-148	109	3	.	.	PUNCT
ctmj-148	110	1	the	the	DET
ctmj-148	110	2	full	full	ADJ
ctmj-148	110	3	ion	ion	NOUN
ctmj-148	110	4	chromatogram	chromatogram	NOUN
ctmj-148	110	5	of	of	ADP
ctmj-148	110	6	a	a	DET
ctmj-148	110	7	fecal	fecal	ADJ
ctmj-148	110	8	sample	sample	NOUN
ctmj-148	110	9	is	be	AUX
ctmj-148	110	10	shown	show	VERB
ctmj-148	110	11	in	in	ADP
ctmj-148	110	12	fig	fig	NOUN
ctmj-148	110	13	.	.	PUNCT
ctmj-148	111	1	2a	2a	NUM
ctmj-148	111	2	and	and	CCONJ
ctmj-148	111	3	the	the	DET
ctmj-148	111	4	extract	extract	NOUN
ctmj-148	111	5	ion	ion	NOUN
ctmj-148	111	6	chromatogram	chromatogram	NOUN
ctmj-148	111	7	for	for	ADP
ctmj-148	111	8	emodin	emodin	NOUN
ctmj-148	111	9	-	-	PUNCT
ctmj-148	111	10	o	o	NOUN
ctmj-148	111	11	-	-	ADJ
ctmj-148	111	12	glucuronide	glucuronide	NOUN
ctmj-148	111	13	is	be	AUX
ctmj-148	111	14	shown	show	VERB
ctmj-148	111	15	in	in	ADP
ctmj-148	111	16	fig	fig	NOUN
ctmj-148	111	17	.	.	PUNCT
ctmj-148	112	1	2b	2b	NUM
ctmj-148	112	2	.	.	PUNCT
ctmj-148	113	1	in	in	ADP
ctmj-148	113	2	negative	negative	ADJ
ctmj-148	113	3	mode	mode	NOUN
ctmj-148	113	4	,	,	PUNCT
ctmj-148	113	5	the	the	DET
ctmj-148	113	6	diagnostic	diagnostic	ADJ
ctmj-148	113	7	ion	ion	NOUN
ctmj-148	113	8	fragments	fragment	NOUN
ctmj-148	113	9	of	of	ADP
ctmj-148	113	10	m	m	NOUN
ctmj-148	113	11	/	/	SYM
ctmj-148	113	12	z	z	PROPN
ctmj-148	113	13	269.0451	269.0451	NUM
ctmj-148	113	14	and	and	CCONJ
ctmj-148	113	15	225.0552	225.0552	NUM
ctmj-148	113	16	were	be	AUX
ctmj-148	113	17	detected	detect	VERB
ctmj-148	113	18	,	,	PUNCT
ctmj-148	113	19	which	which	PRON
ctmj-148	113	20	suggested	suggest	VERB
ctmj-148	113	21	that	that	SCONJ
ctmj-148	113	22	the	the	DET
ctmj-148	113	23	skeleton	skeleton	NOUN
ctmj-148	113	24	of	of	ADP
ctmj-148	113	25	the	the	DET
ctmj-148	113	26	target	target	NOUN
ctmj-148	113	27	compound	compound	NOUN
ctmj-148	113	28	was	be	AUX
ctmj-148	113	29	the	the	DET
ctmj-148	113	30	same	same	ADJ
ctmj-148	113	31	as	as	ADP
ctmj-148	113	32	that	that	PRON
ctmj-148	113	33	of	of	ADP
ctmj-148	113	34	emodin	emodin	PROPN
ctmj-148	113	35	(	(	PUNCT
ctmj-148	113	36	fig	fig	NOUN
ctmj-148	113	37	.	.	PUNCT
ctmj-148	114	1	2c	2c	NUM
ctmj-148	114	2	)	)	PUNCT
ctmj-148	114	3	.	.	PUNCT
ctmj-148	115	1	in	in	ADP
ctmj-148	115	2	addition	addition	NOUN
ctmj-148	115	3	,	,	PUNCT
ctmj-148	115	4	the	the	DET
ctmj-148	115	5	detection	detection	NOUN
ctmj-148	115	6	of	of	ADP
ctmj-148	115	7	a	a	DET
ctmj-148	115	8	quasi	quasi	ADJ
ctmj-148	115	9	-	-	ADJ
ctmj-148	115	10	molecular	molecular	ADJ
ctmj-148	115	11	ion	ion	NOUN
ctmj-148	115	12	of	of	ADP
ctmj-148	115	13	m	m	PROPN
ctmj-148	115	14	/	/	SYM
ctmj-148	115	15	z	z	NOUN
ctmj-148	115	16	445.0765	445.0765	NUM
ctmj-148	116	1	[	[	X
ctmj-148	116	2	m	m	NOUN
ctmj-148	116	3	h	h	X
ctmj-148	116	4	]	]	X
ctmj-148	116	5	,	,	PUNCT
ctmj-148	116	6	which	which	PRON
ctmj-148	116	7	differs	differ	VERB
ctmj-148	116	8	from	from	ADP
ctmj-148	116	9	the	the	DET
ctmj-148	116	10	expected	expect	VERB
ctmj-148	116	11	m	m	PROPN
ctmj-148	116	12	/	/	SYM
ctmj-148	116	13	z	z	PROPN
ctmj-148	116	14	269.0451	269.0451	NUM
ctmj-148	116	15	for	for	ADP
ctmj-148	116	16	emodin	emodin	VERB
ctmj-148	116	17	by	by	ADP
ctmj-148	116	18	176.0814	176.0814	NUM
ctmj-148	116	19	da	da	NOUN
ctmj-148	116	20	,	,	PUNCT
ctmj-148	116	21	implied	imply	VERB
ctmj-148	116	22	that	that	SCONJ
ctmj-148	116	23	the	the	DET
ctmj-148	116	24	compound	compound	NOUN
ctmj-148	116	25	was	be	AUX
ctmj-148	116	26	emodin	emodin	VERB
ctmj-148	116	27	-	-	PUNCT
ctmj-148	116	28	o	o	NOUN
ctmj-148	116	29	-	-	ADJ
ctmj-148	116	30	glucuronide	glucuronide	ADJ
ctmj-148	116	31	(	(	PUNCT
ctmj-148	116	32	fig	fig	NOUN
ctmj-148	116	33	.	.	PUNCT
ctmj-148	117	1	2d	2d	NOUN
ctmj-148	117	2	)	)	PUNCT
ctmj-148	117	3	.	.	PUNCT
ctmj-148	118	1	overall	overall	ADV
ctmj-148	118	2	,	,	PUNCT
ctmj-148	118	3	38	38	NUM
ctmj-148	118	4	derivatives	derivative	NOUN
ctmj-148	118	5	of	of	ADP
ctmj-148	118	6	known	know	VERB
ctmj-148	118	7	rhubarb	rhubarb	NOUN
ctmj-148	118	8	components	component	NOUN
ctmj-148	118	9	,	,	PUNCT
ctmj-148	118	10	including	include	VERB
ctmj-148	118	11	17	17	NUM
ctmj-148	118	12	anthraquinones	anthraquinone	NOUN
ctmj-148	118	13	and	and	CCONJ
ctmj-148	118	14	21	21	NUM
ctmj-148	118	15	anthrones	anthrone	NOUN
ctmj-148	118	16	,	,	PUNCT
ctmj-148	118	17	were	be	AUX
ctmj-148	118	18	identified	identify	VERB
ctmj-148	118	19	in	in	ADP
ctmj-148	118	20	colorectal	colorectal	ADJ
ctmj-148	118	21	samples	sample	NOUN
ctmj-148	118	22	,	,	PUNCT
ctmj-148	118	23	including	include	VERB
ctmj-148	118	24	prototypes	prototype	NOUN
ctmj-148	118	25	and	and	CCONJ
ctmj-148	118	26	various	various	ADJ
ctmj-148	118	27	metabolites	metabolite	NOUN
ctmj-148	118	28	(	(	PUNCT
ctmj-148	118	29	fig	fig	NOUN
ctmj-148	118	30	.	.	PUNCT
ctmj-148	119	1	3	3	NUM
ctmj-148	119	2	)	)	PUNCT
ctmj-148	119	3	,	,	PUNCT
ctmj-148	119	4	and	and	CCONJ
ctmj-148	119	5	the	the	DET
ctmj-148	119	6	compound	compound	NOUN
ctmj-148	119	7	identification	identification	NOUN
ctmj-148	119	8	data	datum	NOUN
ctmj-148	119	9	are	be	AUX
ctmj-148	119	10	presented	present	VERB
ctmj-148	119	11	in	in	ADP
ctmj-148	119	12	supplemental	supplemental	ADJ
ctmj-148	119	13	tables	table	NOUN
ctmj-148	119	14	2‒4	2‒4	NUM
ctmj-148	119	15	.	.	PUNCT
ctmj-148	120	1	construction	construction	NOUN
ctmj-148	120	2	of	of	ADP
ctmj-148	120	3	a	a	DET
ctmj-148	120	4	target	target	NOUN
ctmj-148	120	5	protein	protein	NOUN
ctmj-148	120	6	database	database	NOUN
ctmj-148	120	7	to	to	PART
ctmj-148	120	8	determine	determine	VERB
ctmj-148	120	9	the	the	DET
ctmj-148	120	10	mechanism	mechanism	NOUN
ctmj-148	120	11	of	of	ADP
ctmj-148	120	12	the	the	DET
ctmj-148	120	13	laxative	laxative	ADJ
ctmj-148	120	14	effect	effect	NOUN
ctmj-148	120	15	of	of	ADP
ctmj-148	120	16	rhubarb	rhubarb	NOUN
ctmj-148	120	17	,	,	PUNCT
ctmj-148	120	18	the	the	DET
ctmj-148	120	19	molecular	molecular	ADJ
ctmj-148	120	20	targets	target	NOUN
ctmj-148	120	21	of	of	ADP
ctmj-148	120	22	clinically	clinically	ADV
ctmj-148	120	23	-	-	PUNCT
ctmj-148	120	24	approved	approve	VERB
ctmj-148	120	25	laxatives	laxative	NOUN
ctmj-148	120	26	were	be	AUX
ctmj-148	120	27	identified	identify	VERB
ctmj-148	120	28	using	use	VERB
ctmj-148	120	29	the	the	DET
ctmj-148	120	30	ttd	ttd	NOUN
ctmj-148	120	31	,	,	PUNCT
ctmj-148	120	32	drug	drug	NOUN
ctmj-148	120	33	bank	bank	NOUN
ctmj-148	120	34	database	database	NOUN
ctmj-148	120	35	,	,	PUNCT
ctmj-148	120	36	and	and	CCONJ
ctmj-148	120	37	published	publish	VERB
ctmj-148	120	38	literature	literature	NOUN
ctmj-148	120	39	.	.	PUNCT
ctmj-148	121	1	as	as	SCONJ
ctmj-148	121	2	shown	show	VERB
ctmj-148	121	3	in	in	ADP
ctmj-148	121	4	supplemental	supplemental	ADJ
ctmj-148	121	5	table	table	NOUN
ctmj-148	121	6	5	5	NUM
ctmj-148	121	7	,	,	PUNCT
ctmj-148	121	8	there	there	PRON
ctmj-148	121	9	are	be	VERB
ctmj-148	121	10	17	17	NUM
ctmj-148	121	11	types	type	NOUN
ctmj-148	121	12	of	of	ADP
ctmj-148	121	13	molecular	molecular	ADJ
ctmj-148	121	14	target	target	NOUN
ctmj-148	121	15	for	for	ADP
ctmj-148	121	16	laxatives	laxative	NOUN
ctmj-148	121	17	.	.	PUNCT
ctmj-148	122	1	all	all	PRON
ctmj-148	122	2	of	of	ADP
ctmj-148	122	3	these	these	PRON
ctmj-148	122	4	,	,	PUNCT
ctmj-148	122	5	which	which	PRON
ctmj-148	122	6	include	include	VERB
ctmj-148	122	7	channel	channel	NOUN
ctmj-148	122	8	proteins	protein	NOUN
ctmj-148	122	9	and	and	CCONJ
ctmj-148	122	10	receptors	receptor	NOUN
ctmj-148	122	11	,	,	PUNCT
ctmj-148	122	12	have	have	AUX
ctmj-148	122	13	been	be	AUX
ctmj-148	122	14	identified	identify	VERB
ctmj-148	122	15	to	to	PART
ctmj-148	122	16	mediate	mediate	VERB
ctmj-148	122	17	effective	effective	ADJ
ctmj-148	122	18	treatments	treatment	NOUN
ctmj-148	122	19	for	for	ADP
ctmj-148	122	20	constipation	constipation	NOUN
ctmj-148	122	21	.	.	PUNCT
ctmj-148	123	1	for	for	ADP
ctmj-148	123	2	instance	instance	NOUN
ctmj-148	123	3	,	,	PUNCT
ctmj-148	123	4	magnesium	magnesium	NOUN
ctmj-148	123	5	sulfate	sulfate	NOUN
ctmj-148	123	6	,	,	PUNCT
ctmj-148	123	7	which	which	PRON
ctmj-148	123	8	is	be	AUX
ctmj-148	123	9	classified	classify	VERB
ctmj-148	123	10	as	as	ADP
ctmj-148	123	11	an	an	DET
ctmj-148	123	12	osmotic	osmotic	ADJ
ctmj-148	123	13	laxative	laxative	NOUN
ctmj-148	123	14	,	,	PUNCT
ctmj-148	123	15	increases	increase	VERB
ctmj-148	123	16	aqp3	aqp3	NOUN
ctmj-148	123	17	expression	expression	NOUN
ctmj-148	123	18	in	in	ADP
ctmj-148	123	19	the	the	DET
ctmj-148	123	20	epithelial	epithelial	ADJ
ctmj-148	123	21	cells	cell	NOUN
ctmj-148	123	22	,	,	PUNCT
ctmj-148	123	23	which	which	PRON
ctmj-148	123	24	has	have	VERB
ctmj-148	123	25	the	the	DET
ctmj-148	123	26	effect	effect	NOUN
ctmj-148	123	27	of	of	ADP
ctmj-148	123	28	retaining	retain	VERB
ctmj-148	123	29	water	water	NOUN
ctmj-148	123	30	in	in	ADP
ctmj-148	123	31	the	the	DET
ctmj-148	123	32	intestinal	intestinal	ADJ
ctmj-148	123	33	lumen	luman	NOUN
ctmj-148	123	34	and	and	CCONJ
ctmj-148	123	35	promoting	promote	VERB
ctmj-148	123	36	defecation.23	defecation.23	NOUN
ctmj-148	123	37	in	in	ADP
ctmj-148	123	38	addition	addition	NOUN
ctmj-148	123	39	,	,	PUNCT
ctmj-148	123	40	linaclotide	linaclotide	ADP
ctmj-148	123	41	is	be	AUX
ctmj-148	123	42	a	a	DET
ctmj-148	123	43	secretagogue	secretagogue	NOUN
ctmj-148	123	44	that	that	PRON
ctmj-148	123	45	activates	activate	VERB
ctmj-148	123	46	the	the	DET
ctmj-148	123	47	guanylate	guanylate	NOUN
ctmj-148	123	48	cyclase	cyclase	NOUN
ctmj-148	123	49	-	-	PUNCT
ctmj-148	123	50	c	c	NOUN
ctmj-148	123	51	receptor	receptor	NOUN
ctmj-148	123	52	on	on	ADP
ctmj-148	123	53	intestinal	intestinal	ADJ
ctmj-148	123	54	epithelial	epithelial	ADJ
ctmj-148	123	55	cells	cell	NOUN
ctmj-148	123	56	to	to	PART
ctmj-148	123	57	increase	increase	VERB
ctmj-148	123	58	fluid	fluid	ADJ
ctmj-148	123	59	secretion	secretion	NOUN
ctmj-148	123	60	into	into	ADP
ctmj-148	123	61	the	the	DET
ctmj-148	123	62	intestinal	intestinal	ADJ
ctmj-148	123	63	lumen.24,25	lumen.24,25	NOUN
ctmj-148	123	64	some	some	DET
ctmj-148	123	65	previous	previous	ADJ
ctmj-148	123	66	studies	study	NOUN
ctmj-148	123	67	have	have	AUX
ctmj-148	123	68	shown	show	VERB
ctmj-148	123	69	that	that	SCONJ
ctmj-148	123	70	the	the	DET
ctmj-148	123	71	number	number	NOUN
ctmj-148	123	72	of	of	ADP
ctmj-148	123	73	interstitial	interstitial	ADJ
ctmj-148	123	74	cells	cell	NOUN
ctmj-148	123	75	of	of	ADP
ctmj-148	123	76	cajal	cajal	PROPN
ctmj-148	123	77	(	(	PUNCT
ctmj-148	123	78	iccs	iccs	NOUN
ctmj-148	123	79	)	)	PUNCT
ctmj-148	123	80	is	be	AUX
ctmj-148	123	81	lower	low	ADJ
ctmj-148	123	82	in	in	ADP
ctmj-148	123	83	the	the	DET
ctmj-148	123	84	colons	colon	NOUN
ctmj-148	123	85	of	of	ADP
ctmj-148	123	86	patients	patient	NOUN
ctmj-148	123	87	with	with	ADP
ctmj-148	123	88	slow	slow	ADJ
ctmj-148	123	89	-	-	PUNCT
ctmj-148	123	90	transport	transport	NOUN
ctmj-148	123	91	constipation,26,27	constipation,26,27	NOUN
ctmj-148	123	92	and	and	CCONJ
ctmj-148	123	93	c	c	NOUN
ctmj-148	123	94	-	-	PUNCT
ctmj-148	123	95	kit	kit	NOUN
ctmj-148	123	96	is	be	AUX
ctmj-148	123	97	a	a	DET
ctmj-148	123	98	specific	specific	ADJ
ctmj-148	123	99	marker	marker	NOUN
ctmj-148	123	100	of	of	ADP
ctmj-148	123	101	iccs	iccs	PROPN
ctmj-148	123	102	,	,	PUNCT
ctmj-148	123	103	which	which	PRON
ctmj-148	123	104	have	have	AUX
ctmj-148	123	105	been	be	AUX
ctmj-148	123	106	shown	show	VERB
ctmj-148	123	107	to	to	PART
ctmj-148	123	108	be	be	AUX
ctmj-148	123	109	intestinal	intestinal	ADJ
ctmj-148	123	110	pacemaker	pacemaker	NOUN
ctmj-148	123	111	cells.28	cells.28	NOUN
ctmj-148	123	112	finally	finally	ADV
ctmj-148	123	113	,	,	PUNCT
ctmj-148	123	114	prucalopride	prucalopride	NOUN
ctmj-148	123	115	,	,	PUNCT
ctmj-148	123	116	a	a	DET
ctmj-148	123	117	highly	highly	ADV
ctmj-148	123	118	selective	selective	ADJ
ctmj-148	123	119	5	5	NUM
ctmj-148	123	120	-	-	PUNCT
ctmj-148	123	121	ht4	ht4	NOUN
ctmj-148	123	122	receptor	receptor	NOUN
ctmj-148	123	123	agonist	agonist	NOUN
ctmj-148	123	124	,	,	PUNCT
ctmj-148	123	125	directly	directly	ADV
ctmj-148	123	126	activates	activate	VERB
ctmj-148	123	127	afferent	afferent	ADJ
ctmj-148	123	128	neurons	neuron	NOUN
ctmj-148	123	129	and	and	CCONJ
ctmj-148	123	130	improves	improve	VERB
ctmj-148	123	131	intestinal	intestinal	ADJ
ctmj-148	123	132	motility.29,30	motility.29,30	NOUN
ctmj-148	123	133	the	the	DET
ctmj-148	123	134	creation	creation	NOUN
ctmj-148	123	135	of	of	ADP
ctmj-148	123	136	a	a	DET
ctmj-148	123	137	molecular	molecular	ADJ
ctmj-148	123	138	target	target	NOUN
ctmj-148	123	139	database	database	NOUN
ctmj-148	123	140	for	for	ADP
ctmj-148	123	141	laxatives	laxative	NOUN
ctmj-148	123	142	provided	provide	VERB
ctmj-148	123	143	a	a	DET
ctmj-148	123	144	tool	tool	NOUN
ctmj-148	123	145	for	for	SCONJ
ctmj-148	123	146	us	we	PRON
ctmj-148	123	147	to	to	PART
ctmj-148	123	148	identify	identify	VERB
ctmj-148	123	149	potential	potential	ADJ
ctmj-148	123	150	targets	target	NOUN
ctmj-148	123	151	and	and	CCONJ
ctmj-148	123	152	bioactive	bioactive	VERB
ctmj-148	123	153	derivatives	derivative	NOUN
ctmj-148	123	154	of	of	ADP
ctmj-148	123	155	rhubarb	rhubarb	NOUN
ctmj-148	123	156	compounds	compound	NOUN
ctmj-148	123	157	for	for	ADP
ctmj-148	123	158	the	the	DET
ctmj-148	123	159	treatment	treatment	NOUN
ctmj-148	123	160	of	of	ADP
ctmj-148	123	161	constipation	constipation	NOUN
ctmj-148	123	162	.	.	PUNCT
ctmj-148	124	1	candidate	candidate	NOUN
ctmj-148	124	2	colorectal	colorectal	ADJ
ctmj-148	124	3	molecular	molecular	ADJ
ctmj-148	124	4	targets	target	NOUN
ctmj-148	124	5	and	and	CCONJ
ctmj-148	124	6	potentially	potentially	ADV
ctmj-148	124	7	bioactive	bioactive	VERB
ctmj-148	124	8	compounds	compound	NOUN
ctmj-148	124	9	to	to	PART
ctmj-148	124	10	screen	screen	VERB
ctmj-148	124	11	the	the	DET
ctmj-148	124	12	candidate	candidate	NOUN
ctmj-148	124	13	targets	target	NOUN
ctmj-148	124	14	and	and	CCONJ
ctmj-148	124	15	bioactive	bioactive	VERB
ctmj-148	124	16	rhubarb	rhubarb	NOUN
ctmj-148	124	17	derivatives	derivative	NOUN
ctmj-148	124	18	,	,	PUNCT
ctmj-148	124	19	molecular	molecular	ADJ
ctmj-148	124	20	docking	docking	NOUN
ctmj-148	124	21	modeling	modeling	NOUN
ctmj-148	124	22	was	be	AUX
ctmj-148	124	23	performed	perform	VERB
ctmj-148	124	24	using	use	VERB
ctmj-148	124	25	38	38	NUM
ctmj-148	124	26	rhubarb	rhubarb	NOUN
ctmj-148	124	27	derivatives	derivative	NOUN
ctmj-148	124	28	from	from	ADP
ctmj-148	124	29	the	the	DET
ctmj-148	124	30	colorectum	colorectum	NOUN
ctmj-148	124	31	and	and	CCONJ
ctmj-148	124	32	17	17	NUM
ctmj-148	124	33	endogenous	endogenous	ADJ
ctmj-148	124	34	fig	fig	NOUN
ctmj-148	124	35	.	.	PUNCT
ctmj-148	125	1	2	2	X
ctmj-148	125	2	.	.	X
ctmj-148	125	3	the	the	DET
ctmj-148	125	4	identification	identification	NOUN
ctmj-148	125	5	process	process	NOUN
ctmj-148	125	6	for	for	ADP
ctmj-148	125	7	emodin	emodin	NOUN
ctmj-148	125	8	-	-	PUNCT
ctmj-148	125	9	o	o	NOUN
ctmj-148	125	10	-	-	ADJ
ctmj-148	125	11	glucuronide	glucuronide	ADJ
ctmj-148	125	12	(	(	PUNCT
ctmj-148	125	13	a	a	NOUN
ctmj-148	125	14	)	)	PUNCT
ctmj-148	125	15	the	the	DET
ctmj-148	125	16	total	total	ADJ
ctmj-148	125	17	ion	ion	NOUN
ctmj-148	125	18	chromatogram	chromatogram	NOUN
ctmj-148	125	19	of	of	ADP
ctmj-148	125	20	a	a	DET
ctmj-148	125	21	fecal	fecal	ADJ
ctmj-148	125	22	sample	sample	NOUN
ctmj-148	125	23	(	(	PUNCT
ctmj-148	125	24	b	b	X
ctmj-148	125	25	)	)	PUNCT
ctmj-148	125	26	the	the	DET
ctmj-148	125	27	extract	extract	NOUN
ctmj-148	125	28	ion	ion	NOUN
ctmj-148	125	29	chromatogram	chromatogram	NOUN
ctmj-148	125	30	(	(	PUNCT
ctmj-148	125	31	c	c	NOUN
ctmj-148	125	32	)	)	PUNCT
ctmj-148	125	33	mass	mass	ADJ
ctmj-148	125	34	spectrometry	spectrometry	NOUN
ctmj-148	125	35	(	(	PUNCT
ctmj-148	125	36	ms)/ms	ms)/ms	PROPN
ctmj-148	125	37	spectrum	spectrum	NOUN
ctmj-148	125	38	(	(	PUNCT
ctmj-148	125	39	d	d	X
ctmj-148	125	40	)	)	PUNCT
ctmj-148	125	41	the	the	DET
ctmj-148	125	42	identification	identification	NOUN
ctmj-148	125	43	of	of	ADP
ctmj-148	125	44	an	an	DET
ctmj-148	125	45	ion	ion	NOUN
ctmj-148	125	46	with	with	ADP
ctmj-148	125	47	m	m	PROPN
ctmj-148	125	48	/	/	SYM
ctmj-148	125	49	z	z	NOUN
ctmj-148	125	50	445.0765	445.0765	NUM
ctmj-148	125	51	in	in	ADP
ctmj-148	125	52	the	the	DET
ctmj-148	125	53	fecal	fecal	ADJ
ctmj-148	125	54	sample	sample	NOUN
ctmj-148	125	55	.	.	PUNCT
ctmj-148	126	1	fig	fig	NOUN
ctmj-148	126	2	.	.	PUNCT
ctmj-148	127	1	3	3	X
ctmj-148	127	2	.	.	X
ctmj-148	127	3	structures	structure	NOUN
ctmj-148	127	4	of	of	ADP
ctmj-148	127	5	the	the	DET
ctmj-148	127	6	38	38	NUM
ctmj-148	127	7	rhubarb	rhubarb	NOUN
ctmj-148	127	8	derivatives	derivative	NOUN
ctmj-148	127	9	identified	identify	VERB
ctmj-148	127	10	in	in	ADP
ctmj-148	127	11	fecal	fecal	ADJ
ctmj-148	127	12	amples	ample	NOUN
ctmj-148	127	13	.	.	PUNCT
ctmj-148	128	1	molecules	molecule	NOUN
ctmj-148	128	2	that	that	PRON
ctmj-148	128	3	mediate	mediate	VERB
ctmj-148	128	4	laxative	laxative	NOUN
ctmj-148	128	5	effects	effect	NOUN
ctmj-148	128	6	.	.	PUNCT
ctmj-148	129	1	first	first	ADV
ctmj-148	129	2	,	,	PUNCT
ctmj-148	129	3	homology	homology	NOUN
ctmj-148	129	4	modeling	modeling	NOUN
ctmj-148	129	5	was	be	AUX
ctmj-148	129	6	conducted	conduct	VERB
ctmj-148	129	7	to	to	PART
ctmj-148	129	8	predict	predict	VERB
ctmj-148	129	9	the	the	DET
ctmj-148	129	10	structures	structure	NOUN
ctmj-148	129	11	of	of	ADP
ctmj-148	129	12	proteins	protein	NOUN
ctmj-148	129	13	that	that	PRON
ctmj-148	129	14	were	be	AUX
ctmj-148	129	15	not	not	PART
ctmj-148	129	16	found	find	VERB
ctmj-148	129	17	in	in	ADP
ctmj-148	129	18	the	the	DET
ctmj-148	129	19	database	database	NOUN
ctmj-148	129	20	,	,	PUNCT
ctmj-148	129	21	such	such	ADJ
ctmj-148	129	22	as	as	ADP
ctmj-148	129	23	5	5	NUM
ctmj-148	129	24	-	-	PUNCT
ctmj-148	129	25	ht4	ht4	NOUN
ctmj-148	129	26	and	and	CCONJ
ctmj-148	129	27	aqp3	aqp3	PROPN
ctmj-148	129	28	.	.	PUNCT
ctmj-148	130	1	the	the	DET
ctmj-148	130	2	models	model	NOUN
ctmj-148	130	3	generated	generate	VERB
ctmj-148	130	4	for	for	ADP
ctmj-148	130	5	5	5	NUM
ctmj-148	130	6	-	-	SYM
ctmj-148	130	7	ht	ht	INTJ
ctmj-148	130	8	4	4	NUM
ctmj-148	130	9	and	and	CCONJ
ctmj-148	130	10	aqp3	aqp3	PROPN
ctmj-148	130	11	are	be	AUX
ctmj-148	130	12	depicted	depict	VERB
ctmj-148	130	13	in	in	ADP
ctmj-148	130	14	fig	fig	NOUN
ctmj-148	130	15	.	.	PUNCT
ctmj-148	131	1	4a	4a	NOUN
ctmj-148	131	2	and	and	CCONJ
ctmj-148	131	3	b	b	NOUN
ctmj-148	131	4	,	,	PUNCT
ctmj-148	131	5	ctmj	ctmj	NOUN
ctmj-148	131	6	|	|	ADV
ctmj-148	131	7	traditionalmedicinejournals.com	traditionalmedicinejournals.com	X
ctmj-148	131	8	issn	issn	PROPN
ctmj-148	131	9	:	:	PUNCT
ctmj-148	131	10	2693	2693	NUM
ctmj-148	131	11	6356	6356	NUM
ctmj-148	131	12	2024	2024	NUM
ctmj-148	131	13	|	|	ADV
ctmj-148	131	14	vol	vol	NOUN
ctmj-148	131	15	7	7	NUM
ctmj-148	131	16	|	|	NOUN
ctmj-148	131	17	issue	issue	VERB
ctmj-148	131	18	1	1	NUM
ctmj-148	131	19	fig	fig	NOUN
ctmj-148	131	20	.	.	PUNCT
ctmj-148	132	1	4	4	X
ctmj-148	132	2	.	.	PUNCT
ctmj-148	132	3	structural	structural	ADJ
ctmj-148	132	4	modeling	modeling	NOUN
ctmj-148	132	5	of	of	ADP
ctmj-148	132	6	molecules	molecule	NOUN
ctmj-148	132	7	mediating	mediate	VERB
ctmj-148	132	8	laxative	laxative	NOUN
ctmj-148	132	9	effects	effect	NOUN
ctmj-148	132	10	(	(	PUNCT
ctmj-148	132	11	a	a	X
ctmj-148	132	12	)	)	PUNCT
ctmj-148	132	13	homology	homology	NOUN
ctmj-148	132	14	model	model	NOUN
ctmj-148	132	15	of	of	ADP
ctmj-148	132	16	5	5	NUM
ctmj-148	132	17	-	-	PUNCT
ctmj-148	132	18	ht4	ht4	NOUN
ctmj-148	132	19	(	(	PUNCT
ctmj-148	132	20	b	b	NOUN
ctmj-148	132	21	)	)	PUNCT
ctmj-148	132	22	homology	homology	NOUN
ctmj-148	132	23	model	model	NOUN
ctmj-148	132	24	of	of	ADP
ctmj-148	132	25	aqp3	aqp3	PROPN
ctmj-148	132	26	(	(	PUNCT
ctmj-148	132	27	ced	ced	PROPN
ctmj-148	132	28	)	)	PUNCT
ctmj-148	132	29	ramachandran	ramachandran	PROPN
ctmj-148	132	30	plot	plot	NOUN
ctmj-148	132	31	for	for	ADP
ctmj-148	132	32	5	5	NUM
ctmj-148	132	33	-	-	PUNCT
ctmj-148	132	34	ht4	ht4	NOUN
ctmj-148	132	35	and	and	CCONJ
ctmj-148	132	36	aqp3	aqp3	PROPN
ctmj-148	132	37	.	.	PUNCT
ctmj-148	133	1	dark	dark	PROPN
ctmj-148	133	2	green	green	PROPN
ctmj-148	133	3	dots	dot	NOUN
ctmj-148	133	4	represent	represent	VERB
ctmj-148	133	5	the	the	DET
ctmj-148	133	6	residues	residue	NOUN
ctmj-148	133	7	in	in	ADP
ctmj-148	133	8	favored	favor	VERB
ctmj-148	133	9	regions	region	NOUN
ctmj-148	133	10	,	,	PUNCT
ctmj-148	133	11	yellow	yellow	ADJ
ctmj-148	133	12	dots	dot	NOUN
ctmj-148	133	13	represent	represent	VERB
ctmj-148	133	14	the	the	DET
ctmj-148	133	15	residues	residue	NOUN
ctmj-148	133	16	in	in	ADP
ctmj-148	133	17	permitted	permit	VERB
ctmj-148	133	18	regions	region	NOUN
ctmj-148	133	19	,	,	PUNCT
ctmj-148	133	20	and	and	CCONJ
ctmj-148	133	21	red	red	ADJ
ctmj-148	133	22	crosses	crosse	NOUN
ctmj-148	133	23	represent	represent	VERB
ctmj-148	133	24	the	the	DET
ctmj-148	133	25	residues	residue	NOUN
ctmj-148	133	26	in	in	ADP
ctmj-148	133	27	irrational	irrational	ADJ
ctmj-148	133	28	regions	region	NOUN
ctmj-148	133	29	.	.	PUNCT
ctmj-148	134	1	abbreviations	abbreviation	NOUN
ctmj-148	134	2	:	:	PUNCT
ctmj-148	134	3	5	5	NUM
ctmj-148	134	4	-	-	PUNCT
ctmj-148	134	5	ht4	ht4	NOUN
ctmj-148	134	6	:	:	PUNCT
ctmj-148	134	7	5	5	NUM
ctmj-148	134	8	-	-	PUNCT
ctmj-148	134	9	hydroxytryptamine	hydroxytryptamine	NOUN
ctmj-148	134	10	receptor	receptor	NOUN
ctmj-148	134	11	4	4	NUM
ctmj-148	134	12	;	;	PUNCT
ctmj-148	134	13	aqp3	aqp3	PROPN
ctmj-148	134	14	:	:	PUNCT
ctmj-148	134	15	aquaporin-3	aquaporin-3	PROPN
ctmj-148	134	16	.	.	PROPN
ctmj-148	134	17	respectively	respectively	ADV
ctmj-148	134	18	.	.	PUNCT
ctmj-148	135	1	ramachandran	ramachandran	NOUN
ctmj-148	135	2	plots	plot	VERB
ctmj-148	135	3	for	for	ADP
ctmj-148	135	4	5	5	NUM
ctmj-148	135	5	-	-	PUNCT
ctmj-148	135	6	ht4	ht4	NOUN
ctmj-148	135	7	and	and	CCONJ
ctmj-148	135	8	aqp3	aqp3	PROPN
ctmj-148	135	9	showed	show	VERB
ctmj-148	135	10	that	that	SCONJ
ctmj-148	135	11	more	more	ADJ
ctmj-148	135	12	than	than	ADP
ctmj-148	135	13	99	99	NUM
ctmj-148	135	14	%	%	NOUN
ctmj-148	135	15	of	of	ADP
ctmj-148	135	16	their	their	PRON
ctmj-148	135	17	amino	amino	NOUN
ctmj-148	135	18	acid	acid	NOUN
ctmj-148	135	19	residues	residue	NOUN
ctmj-148	135	20	were	be	AUX
ctmj-148	135	21	in	in	ADP
ctmj-148	135	22	permitted	permit	VERB
ctmj-148	135	23	re	re	NOUN
ctmj-148	135	24	gions	gion	NOUN
ctmj-148	135	25	,	,	PUNCT
ctmj-148	135	26	which	which	PRON
ctmj-148	135	27	indicates	indicate	VERB
ctmj-148	135	28	that	that	SCONJ
ctmj-148	135	29	the	the	DET
ctmj-148	135	30	predicted	predict	VERB
ctmj-148	135	31	3d	3d	NUM
ctmj-148	135	32	structures	structure	NOUN
ctmj-148	135	33	were	be	AUX
ctmj-148	135	34	reasonable	reasonable	ADJ
ctmj-148	135	35	(	(	PUNCT
ctmj-148	135	36	fig	fig	NOUN
ctmj-148	135	37	.	.	PUNCT
ctmj-148	136	1	4c	4c	NOUN
ctmj-148	136	2	and	and	CCONJ
ctmj-148	136	3	d	d	NOUN
ctmj-148	136	4	)	)	PUNCT
ctmj-148	136	5	.	.	PUNCT
ctmj-148	137	1	then	then	ADV
ctmj-148	137	2	,	,	PUNCT
ctmj-148	137	3	on	on	ADP
ctmj-148	137	4	the	the	DET
ctmj-148	137	5	basis	basis	NOUN
ctmj-148	137	6	that	that	SCONJ
ctmj-148	137	7	the	the	DET
ctmj-148	137	8	more	more	ADV
ctmj-148	137	9	negative	negative	ADJ
ctmj-148	137	10	the	the	DET
ctmj-148	137	11	gscore	gscore	NOUN
ctmj-148	137	12	is	be	AUX
ctmj-148	137	13	,	,	PUNCT
ctmj-148	137	14	the	the	DET
ctmj-148	137	15	stronger	strong	ADJ
ctmj-148	137	16	is	be	AUX
ctmj-148	137	17	the	the	DET
ctmj-148	137	18	binding	bind	VERB
ctmj-148	137	19	affinity	affinity	NOUN
ctmj-148	137	20	between	between	ADP
ctmj-148	137	21	table	table	NOUN
ctmj-148	137	22	1	1	NUM
ctmj-148	137	23	g	g	NOUN
ctmj-148	137	24	-	-	PUNCT
ctmj-148	137	25	scores	score	NOUN
ctmj-148	137	26	for	for	ADP
ctmj-148	137	27	the	the	DET
ctmj-148	137	28	binding	binding	NOUN
ctmj-148	137	29	of	of	ADP
ctmj-148	137	30	the	the	DET
ctmj-148	137	31	top	top	ADV
ctmj-148	137	32	-	-	PUNCT
ctmj-148	137	33	ranked	rank	VERB
ctmj-148	137	34	rhubarb	rhubarb	NOUN
ctmj-148	137	35	derivatives	derivative	NOUN
ctmj-148	137	36	with	with	ADP
ctmj-148	137	37	their	their	PRON
ctmj-148	137	38	potential	potential	ADJ
ctmj-148	137	39	molecular	molecular	ADJ
ctmj-148	137	40	targets	target	NOUN
ctmj-148	137	41	.	.	PUNCT
ctmj-148	138	1	no	no	DET
ctmj-148	138	2	.	.	PUNCT
ctmj-148	138	3	ligand	ligand	ADJ
ctmj-148	138	4	receptor	receptor	NOUN
ctmj-148	138	5	(	(	PUNCT
ctmj-148	138	6	kcal	kcal	NOUN
ctmj-148	138	7	/	/	SYM
ctmj-148	138	8	mol	mol	NOUN
ctmj-148	138	9	)	)	PUNCT
ctmj-148	138	10	c	c	NOUN
ctmj-148	138	11	-	-	PUNCT
ctmj-148	138	12	kit	kit	ADJ
ctmj-148	138	13	5	5	NUM
ctmj-148	138	14	-	-	PUNCT
ctmj-148	138	15	ht4	ht4	NOUN
ctmj-148	138	16	aqp3	aqp3	NOUN
ctmj-148	138	17	1	1	NUM
ctmj-148	138	18	aloe	aloe	NOUN
ctmj-148	138	19	-	-	PUNCT
ctmj-148	138	20	emodin	emodin	NOUN
ctmj-148	138	21	—	—	PUNCT
ctmj-148	138	22	8.476	8.476	NUM
ctmj-148	138	23	/	/	SYM
ctmj-148	138	24	—	—	PUNCT
ctmj-148	138	25	5.289	5.289	NUM
ctmj-148	138	26	2	2	NUM
ctmj-148	138	27	emodin	emodin	NOUN
ctmj-148	138	28	—	—	PUNCT
ctmj-148	138	29	9.378	9.378	NUM
ctmj-148	138	30	—	—	PUNCT
ctmj-148	138	31	5.541	5.541	NUM
ctmj-148	138	32	—	—	PUNCT
ctmj-148	138	33	5.743	5.743	NUM
ctmj-148	138	34	3	3	NUM
ctmj-148	138	35	rhein	rhein	NOUN
ctmj-148	138	36	—	—	PUNCT
ctmj-148	138	37	8.453	8.453	NUM
ctmj-148	138	38	—	—	SYM
ctmj-148	138	39	5.963	5.963	NUM
ctmj-148	138	40	—	—	SYM
ctmj-148	138	41	5.270	5.270	NUM
ctmj-148	138	42	4	4	NUM
ctmj-148	138	43	chrysophanol	chrysophanol	NOUN
ctmj-148	138	44	—	—	PUNCT
ctmj-148	138	45	8.530	8.530	NUM
ctmj-148	138	46	—	—	PUNCT
ctmj-148	138	47	6.221	6.221	NUM
ctmj-148	138	48	—	—	PUNCT
ctmj-148	138	49	5.514	5.514	NUM
ctmj-148	138	50	5	5	NUM
ctmj-148	138	51	physcion	physcion	NOUN
ctmj-148	138	52	—	—	PUNCT
ctmj-148	138	53	8.275	8.275	NUM
ctmj-148	138	54	—	—	PUNCT
ctmj-148	138	55	5.241	5.241	NUM
ctmj-148	138	56	—	—	PUNCT
ctmj-148	138	57	5.987	5.987	NUM
ctmj-148	138	58	6	6	NUM
ctmj-148	138	59	sennoside	sennoside	NOUN
ctmj-148	138	60	a	a	DET
ctmj-148	138	61	—	—	PUNCT
ctmj-148	138	62	6.854	6.854	NUM
ctmj-148	138	63	—	—	PUNCT
ctmj-148	138	64	8.891	8.891	NUM
ctmj-148	138	65	/	/	SYM
ctmj-148	138	66	7	7	NUM
ctmj-148	138	67	sennoside	sennoside	NOUN
ctmj-148	138	68	c	c	NOUN
ctmj-148	138	69	—	—	PUNCT
ctmj-148	138	70	9.019	9.019	NUM
ctmj-148	138	71	—	—	PUNCT
ctmj-148	138	72	8.810	8.810	NUM
ctmj-148	138	73	/	/	SYM
ctmj-148	138	74	8	8	NUM
ctmj-148	138	75	physcionanthrone	physcionanthrone	NOUN
ctmj-148	138	76	—	—	PUNCT
ctmj-148	138	77	9.069	9.069	NUM
ctmj-148	138	78	—	—	PUNCT
ctmj-148	138	79	5.246	5.246	NUM
ctmj-148	138	80	—	—	PUNCT
ctmj-148	138	81	6.809	6.809	NUM
ctmj-148	138	82	9	9	NUM
ctmj-148	138	83	aloe	aloe	NOUN
ctmj-148	138	84	-	-	PUNCT
ctmj-148	138	85	emodinanthrone	emodinanthrone	NOUN
ctmj-148	138	86	—	—	PUNCT
ctmj-148	138	87	9.278	9.278	NUM
ctmj-148	138	88	—	—	PUNCT
ctmj-148	138	89	5.163	5.163	NUM
ctmj-148	138	90	—	—	PUNCT
ctmj-148	138	91	6.165	6.165	NUM
ctmj-148	138	92	10	10	NUM
ctmj-148	138	93	rheinanthrone	rheinanthrone	NOUN
ctmj-148	138	94	—	—	PUNCT
ctmj-148	138	95	9.747	9.747	NUM
ctmj-148	138	96	—	—	PUNCT
ctmj-148	138	97	5.914	5.914	NUM
ctmj-148	138	98	—	—	PUNCT
ctmj-148	138	99	5.763	5.763	NUM
ctmj-148	138	100	abbreviations	abbreviation	NOUN
ctmj-148	138	101	:	:	PUNCT
ctmj-148	138	102	5	5	NUM
ctmj-148	138	103	-	-	PUNCT
ctmj-148	138	104	ht4	ht4	NOUN
ctmj-148	138	105	:	:	PUNCT
ctmj-148	138	106	5	5	NUM
ctmj-148	138	107	-	-	PUNCT
ctmj-148	138	108	hydroxytryptamine	hydroxytryptamine	NOUN
ctmj-148	138	109	receptor	receptor	NOUN
ctmj-148	138	110	4	4	NUM
ctmj-148	138	111	;	;	PUNCT
ctmj-148	138	112	aqp3	aqp3	PROPN
ctmj-148	138	113	:	:	PUNCT
ctmj-148	138	114	aquaporin-3	aquaporin-3	PROPN
ctmj-148	138	115	.	.	PUNCT
ctmj-148	139	1	the	the	DET
ctmj-148	139	2	compound	compound	NOUN
ctmj-148	139	3	and	and	CCONJ
ctmj-148	139	4	receptor	receptor	NOUN
ctmj-148	139	5	,	,	PUNCT
ctmj-148	139	6	we	we	PRON
ctmj-148	139	7	selected	select	VERB
ctmj-148	139	8	candidate	candidate	NOUN
ctmj-148	139	9	targets	target	NOUN
ctmj-148	139	10	and	and	CCONJ
ctmj-148	139	11	rhubarb	rhubarb	NOUN
ctmj-148	139	12	derivatives	derivative	NOUN
ctmj-148	139	13	.	.	PUNCT
ctmj-148	140	1	the	the	DET
ctmj-148	140	2	g	g	NOUN
ctmj-148	140	3	-	-	PUNCT
ctmj-148	140	4	scores	score	NOUN
ctmj-148	140	5	are	be	AUX
ctmj-148	140	6	listed	list	VERB
ctmj-148	140	7	in	in	ADP
ctmj-148	140	8	table	table	NOUN
ctmj-148	140	9	1	1	NUM
ctmj-148	140	10	,	,	PUNCT
ctmj-148	140	11	and	and	CCONJ
ctmj-148	140	12	show	show	VERB
ctmj-148	140	13	that	that	SCONJ
ctmj-148	140	14	three	three	NUM
ctmj-148	140	15	molecules	molecule	NOUN
ctmj-148	140	16	,	,	PUNCT
ctmj-148	140	17	c	c	NOUN
ctmj-148	140	18	-	-	PUNCT
ctmj-148	140	19	kit	kit	NOUN
ctmj-148	140	20	,	,	PUNCT
ctmj-148	140	21	5	5	NUM
ctmj-148	140	22	-	-	PUNCT
ctmj-148	140	23	ht4	ht4	NOUN
ctmj-148	140	24	,	,	PUNCT
ctmj-148	140	25	and	and	CCONJ
ctmj-148	140	26	aqp3	aqp3	PROPN
ctmj-148	140	27	,	,	PUNCT
ctmj-148	140	28	represented	represent	VERB
ctmj-148	140	29	candidate	candidate	NOUN
ctmj-148	140	30	targets	target	NOUN
ctmj-148	140	31	.	.	PUNCT
ctmj-148	141	1	furthermore	furthermore	ADV
ctmj-148	141	2	,	,	PUNCT
ctmj-148	141	3	10	10	NUM
ctmj-148	141	4	rhubarb	rhubarb	ADJ
ctmj-148	141	5	derivatives	derivative	NOUN
ctmj-148	141	6	(	(	PUNCT
ctmj-148	141	7	aloeemodin	aloeemodin	NOUN
ctmj-148	141	8	,	,	PUNCT
ctmj-148	141	9	emodin	emodin	ADJ
ctmj-148	141	10	,	,	PUNCT
ctmj-148	141	11	rhein	rhein	NOUN
ctmj-148	141	12	,	,	PUNCT
ctmj-148	141	13	chrysophanol	chrysophanol	NOUN
ctmj-148	141	14	,	,	PUNCT
ctmj-148	141	15	physcion	physcion	NOUN
ctmj-148	141	16	,	,	PUNCT
ctmj-148	141	17	sennoside	sennoside	VERB
ctmj-148	141	18	a	a	PRON
ctmj-148	141	19	,	,	PUNCT
ctmj-148	141	20	sennoside	sennoside	NOUN
ctmj-148	141	21	c	c	NOUN
ctmj-148	141	22	,	,	PUNCT
ctmj-148	141	23	physcionanthrone	physcionanthrone	NOUN
ctmj-148	141	24	,	,	PUNCT
ctmj-148	141	25	aloe	aloe	NOUN
ctmj-148	141	26	-	-	PUNCT
ctmj-148	141	27	emodinanthrone	emodinanthrone	NOUN
ctmj-148	141	28	,	,	PUNCT
ctmj-148	141	29	and	and	CCONJ
ctmj-148	141	30	rheinanthrone	rheinanthrone	NOUN
ctmj-148	141	31	)	)	PUNCT
ctmj-148	141	32	,	,	PUNCT
ctmj-148	141	33	were	be	AUX
ctmj-148	141	34	found	find	VERB
ctmj-148	141	35	to	to	PART
ctmj-148	141	36	have	have	VERB
ctmj-148	141	37	strong	strong	ADJ
ctmj-148	141	38	binding	bind	VERB
ctmj-148	141	39	affinities	affinity	NOUN
ctmj-148	141	40	for	for	ADP
ctmj-148	141	41	the	the	DET
ctmj-148	141	42	three	three	NUM
ctmj-148	141	43	targets	target	NOUN
ctmj-148	141	44	,	,	PUNCT
ctmj-148	141	45	and	and	CCONJ
ctmj-148	141	46	were	be	AUX
ctmj-148	141	47	therefore	therefore	ADV
ctmj-148	141	48	selected	select	VERB
ctmj-148	141	49	as	as	ADP
ctmj-148	141	50	potentially	potentially	ADV
ctmj-148	141	51	bioactive	bioactive	ADJ
ctmj-148	141	52	rhubarb	rhubarb	NOUN
ctmj-148	141	53	derivatives	derivative	NOUN
ctmj-148	141	54	.	.	PUNCT
ctmj-148	142	1	to	to	PART
ctmj-148	142	2	gain	gain	VERB
ctmj-148	142	3	insight	insight	NOUN
ctmj-148	142	4	into	into	ADP
ctmj-148	142	5	the	the	DET
ctmj-148	142	6	binding	bind	VERB
ctmj-148	142	7	affinity	affinity	NOUN
ctmj-148	142	8	of	of	ADP
ctmj-148	142	9	rhubarb	rhubarb	ADJ
ctmj-148	142	10	derivatives	derivative	NOUN
ctmj-148	142	11	for	for	ADP
ctmj-148	142	12	the	the	DET
ctmj-148	142	13	binding	bind	VERB
ctmj-148	142	14	sites	site	NOUN
ctmj-148	142	15	of	of	ADP
ctmj-148	142	16	the	the	DET
ctmj-148	142	17	three	three	NUM
ctmj-148	142	18	candidate	candidate	NOUN
ctmj-148	142	19	molecular	molecular	ADJ
ctmj-148	142	20	targets	target	NOUN
ctmj-148	142	21	,	,	PUNCT
ctmj-148	142	22	the	the	DET
ctmj-148	142	23	ligandereceptor	ligandereceptor	NOUN
ctmj-148	142	24	interactions	interaction	NOUN
ctmj-148	142	25	were	be	AUX
ctmj-148	142	26	analyzed	analyze	VERB
ctmj-148	142	27	in	in	ADP
ctmj-148	142	28	silico	silico	NOUN
ctmj-148	142	29	,	,	PUNCT
ctmj-148	142	30	and	and	CCONJ
ctmj-148	142	31	we	we	PRON
ctmj-148	142	32	found	find	VERB
ctmj-148	142	33	that	that	SCONJ
ctmj-148	142	34	all	all	DET
ctmj-148	142	35	10	10	NUM
ctmj-148	142	36	of	of	ADP
ctmj-148	142	37	the	the	DET
ctmj-148	142	38	derivatives	derivative	NOUN
ctmj-148	142	39	are	be	AUX
ctmj-148	142	40	likely	likely	ADJ
ctmj-148	142	41	to	to	PART
ctmj-148	142	42	bind	bind	VERB
ctmj-148	142	43	strongly	strongly	ADV
ctmj-148	142	44	to	to	ADP
ctmj-148	142	45	c	c	NOUN
ctmj-148	142	46	-	-	PUNCT
ctmj-148	142	47	kit	kit	NOUN
ctmj-148	142	48	.	.	PUNCT
ctmj-148	143	1	multiple	multiple	ADJ
ctmj-148	143	2	oxygen	oxygen	NOUN
ctmj-148	143	3	atoms	atom	NOUN
ctmj-148	143	4	in	in	ADP
ctmj-148	143	5	hydroxyl	hydroxyl	NOUN
ctmj-148	143	6	and	and	CCONJ
ctmj-148	143	7	carbonyl	carbonyl	NOUN
ctmj-148	143	8	groups	group	NOUN
ctmj-148	143	9	in	in	ADP
ctmj-148	143	10	the	the	DET
ctmj-148	143	11	basic	basic	ADJ
ctmj-148	143	12	skeleton	skeleton	NOUN
ctmj-148	143	13	of	of	ADP
ctmj-148	143	14	the	the	DET
ctmj-148	143	15	anthraquinones	anthraquinone	NOUN
ctmj-148	143	16	and	and	CCONJ
ctmj-148	143	17	anthrones	anthrone	NOUN
ctmj-148	143	18	were	be	AUX
ctmj-148	143	19	shown	show	VERB
ctmj-148	143	20	to	to	PART
ctmj-148	143	21	be	be	AUX
ctmj-148	143	22	located	locate	VERB
ctmj-148	143	23	in	in	ADP
ctmj-148	143	24	the	the	DET
ctmj-148	143	25	binding	bind	VERB
ctmj-148	143	26	site	site	NOUN
ctmj-148	143	27	and	and	CCONJ
ctmj-148	143	28	to	to	PART
ctmj-148	143	29	form	form	VERB
ctmj-148	143	30	hydrogen	hydrogen	NOUN
ctmj-148	143	31	bonds	bond	NOUN
ctmj-148	143	32	with	with	ADP
ctmj-148	143	33	the	the	DET
ctmj-148	143	34	cys673	cys673	PROPN
ctmj-148	143	35	,	,	PUNCT
ctmj-148	143	36	lys623	lys623	PROPN
ctmj-148	143	37	,	,	PUNCT
ctmj-148	143	38	glu671	glu671	PROPN
ctmj-148	143	39	,	,	PUNCT
ctmj-148	143	40	and	and	CCONJ
ctmj-148	143	41	leu595	leu595	PROPN
ctmj-148	143	42	residues	residue	NOUN
ctmj-148	143	43	of	of	ADP
ctmj-148	143	44	c	c	NOUN
ctmj-148	143	45	-	-	PUNCT
ctmj-148	143	46	kit	kit	NOUN
ctmj-148	143	47	.	.	PUNCT
ctmj-148	144	1	the	the	DET
ctmj-148	144	2	compound	compound	NOUN
ctmj-148	144	3	with	with	ADP
ctmj-148	144	4	the	the	DET
ctmj-148	144	5	strongest	strong	ADJ
ctmj-148	144	6	predicted	predict	VERB
ctmj-148	144	7	binding	bind	VERB
ctmj-148	144	8	affinity	affinity	NOUN
ctmj-148	144	9	for	for	ADP
ctmj-148	144	10	c	c	NOUN
ctmj-148	144	11	-	-	PUNCT
ctmj-148	144	12	kit	kit	NOUN
ctmj-148	144	13	was	be	AUX
ctmj-148	144	14	rheinanthrone	rheinanthrone	NOUN
ctmj-148	144	15	(	(	PUNCT
ctmj-148	144	16	9.747	9.747	NUM
ctmj-148	144	17	kcal	kcal	NOUN
ctmj-148	144	18	/	/	SYM
ctmj-148	144	19	mol	mol	NOUN
ctmj-148	144	20	)	)	PUNCT
ctmj-148	144	21	.	.	PUNCT
ctmj-148	145	1	the	the	DET
ctmj-148	145	2	predicted	predict	VERB
ctmj-148	145	3	interaction	interaction	NOUN
ctmj-148	145	4	is	be	AUX
ctmj-148	145	5	shown	show	VERB
ctmj-148	145	6	in	in	ADP
ctmj-148	145	7	fig	fig	NOUN
ctmj-148	145	8	.	.	PUNCT
ctmj-148	146	1	5a	5a	NUM
ctmj-148	146	2	,	,	PUNCT
ctmj-148	146	3	which	which	PRON
ctmj-148	146	4	involves	involve	VERB
ctmj-148	146	5	three	three	NUM
ctmj-148	146	6	hydrogen	hydrogen	NOUN
ctmj-148	146	7	bonds	bond	NOUN
ctmj-148	146	8	and	and	CCONJ
ctmj-148	146	9	one	one	NUM
ctmj-148	146	10	hp	hp	ADJ
ctmj-148	146	11	conjugation	conjugation	NOUN
ctmj-148	146	12	:	:	PUNCT
ctmj-148	146	13	the	the	DET
ctmj-148	146	14	oxygen	oxygen	NOUN
ctmj-148	146	15	atoms	atom	NOUN
ctmj-148	146	16	at	at	ADP
ctmj-148	146	17	the	the	DET
ctmj-148	146	18	9and	9and	PROPN
ctmj-148	146	19	3	3	NUM
ctmj-148	146	20	-	-	PUNCT
ctmj-148	146	21	sites	site	NOUN
ctmj-148	146	22	of	of	ADP
ctmj-148	146	23	the	the	DET
ctmj-148	146	24	carbonyl	carbonyl	NOUN
ctmj-148	146	25	group	group	NOUN
ctmj-148	146	26	,	,	PUNCT
ctmj-148	146	27	and	and	CCONJ
ctmj-148	146	28	the	the	DET
ctmj-148	146	29	oxygen	oxygen	NOUN
ctmj-148	146	30	atom	atom	NOUN
ctmj-148	146	31	at	at	ADP
ctmj-148	146	32	the	the	DET
ctmj-148	146	33	1	1	NUM
ctmj-148	146	34	-	-	PUNCT
ctmj-148	146	35	site	site	NOUN
ctmj-148	146	36	of	of	ADP
ctmj-148	146	37	the	the	DET
ctmj-148	146	38	hydroxyl	hydroxyl	NOUN
ctmj-148	146	39	—	—	PUNCT
ctmj-148	146	40	—	—	PUNCT
ctmj-148	146	41	fig	fig	NOUN
ctmj-148	146	42	.	.	PUNCT
ctmj-148	147	1	5	5	X
ctmj-148	147	2	.	.	X
ctmj-148	147	3	interaction	interaction	NOUN
ctmj-148	147	4	models	model	NOUN
ctmj-148	147	5	for	for	ADP
ctmj-148	147	6	the	the	DET
ctmj-148	147	7	three	three	NUM
ctmj-148	147	8	candidate	candidate	NOUN
ctmj-148	147	9	molecular	molecular	ADJ
ctmj-148	147	10	mediators	mediator	NOUN
ctmj-148	147	11	of	of	ADP
ctmj-148	147	12	the	the	DET
ctmj-148	147	13	laxative	laxative	ADJ
ctmj-148	147	14	effect	effect	NOUN
ctmj-148	147	15	of	of	ADP
ctmj-148	147	16	rhubarb	rhubarb	NOUN
ctmj-148	147	17	.	.	PUNCT
ctmj-148	148	1	the	the	DET
ctmj-148	148	2	interaction	interaction	NOUN
ctmj-148	148	3	mod	mod	PROPN
ctmj-148	148	4	el	el	PROPN
ctmj-148	148	5	for	for	ADP
ctmj-148	148	6	rheinanthrone	rheinanthrone	NOUN
ctmj-148	148	7	and	and	CCONJ
ctmj-148	148	8	c	c	NOUN
ctmj-148	148	9	-	-	PUNCT
ctmj-148	148	10	kit	kit	NOUN
ctmj-148	148	11	(	(	PUNCT
ctmj-148	148	12	a	a	NOUN
ctmj-148	148	13	)	)	PUNCT
ctmj-148	148	14	,	,	PUNCT
ctmj-148	148	15	sennoside	sennoside	VERB
ctmj-148	148	16	a	a	PRON
ctmj-148	148	17	and	and	CCONJ
ctmj-148	148	18	5hydroxytryptamine	5hydroxytryptamine	NUM
ctmj-148	148	19	receptor	receptor	NOUN
ctmj-148	148	20	4	4	NUM
ctmj-148	148	21	(	(	PUNCT
ctmj-148	148	22	b	b	NOUN
ctmj-148	148	23	)	)	PUNCT
ctmj-148	148	24	,	,	PUNCT
ctmj-148	148	25	and	and	CCONJ
ctmj-148	148	26	physcionanthrone	physcionanthrone	NOUN
ctmj-148	148	27	and	and	CCONJ
ctmj-148	148	28	aquaporin-3	aquaporin-3	PRON
ctmj-148	148	29	(	(	PUNCT
ctmj-148	148	30	c	c	NOUN
ctmj-148	148	31	)	)	PUNCT
ctmj-148	148	32	.	.	PUNCT
ctmj-148	149	1	the	the	DET
ctmj-148	149	2	ligands	ligand	NOUN
ctmj-148	149	3	are	be	AUX
ctmj-148	149	4	yellow	yellow	ADJ
ctmj-148	149	5	and	and	CCONJ
ctmj-148	149	6	the	the	DET
ctmj-148	149	7	surrounding	surround	VERB
ctmj-148	149	8	residues	residue	NOUN
ctmj-148	149	9	in	in	ADP
ctmj-148	149	10	the	the	DET
ctmj-148	149	11	binding	bind	VERB
ctmj-148	149	12	pockets	pocket	NOUN
ctmj-148	149	13	are	be	AUX
ctmj-148	149	14	cyan	cyan	ADJ
ctmj-148	149	15	.	.	PUNCT
ctmj-148	150	1	the	the	DET
ctmj-148	150	2	backbone	backbone	NOUN
ctmj-148	150	3	of	of	ADP
ctmj-148	150	4	the	the	DET
ctmj-148	150	5	receptor	receptor	NOUN
ctmj-148	150	6	is	be	AUX
ctmj-148	150	7	depicted	depict	VERB
ctmj-148	150	8	as	as	ADP
ctmj-148	150	9	a	a	DET
ctmj-148	150	10	light	light	ADJ
ctmj-148	150	11	blue	blue	ADJ
ctmj-148	150	12	ribbon	ribbon	NOUN
ctmj-148	150	13	.	.	PUNCT
ctmj-148	151	1	group	group	NOUN
ctmj-148	151	2	in	in	ADP
ctmj-148	151	3	rheinanthrone	rheinanthrone	NOUN
ctmj-148	151	4	formed	form	VERB
ctmj-148	151	5	hydrogen	hydrogen	NOUN
ctmj-148	151	6	bonds	bond	NOUN
ctmj-148	151	7	with	with	ADP
ctmj-148	151	8	the	the	DET
ctmj-148	151	9	cys673	cys673	PROPN
ctmj-148	151	10	,	,	PUNCT
ctmj-148	151	11	lys623	lys623	NOUN
ctmj-148	151	12	,	,	PUNCT
ctmj-148	151	13	and	and	CCONJ
ctmj-148	151	14	glu671	glu671	VERB
ctmj-148	151	15	residues	residue	NOUN
ctmj-148	151	16	of	of	ADP
ctmj-148	151	17	c	c	NOUN
ctmj-148	151	18	-	-	PUNCT
ctmj-148	151	19	kit	kit	NOUN
ctmj-148	151	20	,	,	PUNCT
ctmj-148	151	21	respectively	respectively	ADV
ctmj-148	151	22	.	.	PUNCT
ctmj-148	152	1	in	in	ADP
ctmj-148	152	2	addition	addition	NOUN
ctmj-148	152	3	,	,	PUNCT
ctmj-148	152	4	the	the	DET
ctmj-148	152	5	carbon	carbon	NOUN
ctmj-148	152	6	atom	atom	NOUN
ctmj-148	152	7	at	at	ADP
ctmj-148	152	8	the	the	DET
ctmj-148	152	9	4	4	NUM
ctmj-148	152	10	-	-	PUNCT
ctmj-148	152	11	site	site	NOUN
ctmj-148	152	12	in	in	ADP
ctmj-148	152	13	rheinanthrone	rheinanthrone	NOUN
ctmj-148	152	14	formed	form	VERB
ctmj-148	152	15	an	an	DET
ctmj-148	152	16	h	h	NOUN
ctmj-148	152	17	-	-	PUNCT
ctmj-148	152	18	p	p	ADJ
ctmj-148	152	19	conjugation	conjugation	NOUN
ctmj-148	152	20	with	with	ADP
ctmj-148	152	21	the	the	DET
ctmj-148	152	22	phe811	phe811	PROPN
ctmj-148	152	23	residue	residue	NOUN
ctmj-148	152	24	of	of	ADP
ctmj-148	152	25	c	c	NOUN
ctmj-148	152	26	-	-	PUNCT
ctmj-148	152	27	kit	kit	NOUN
ctmj-148	152	28	.	.	PROPN
ctmj-148	153	1	sennoside	sennoside	PROPN
ctmj-148	153	2	a	a	DET
ctmj-148	153	3	and	and	CCONJ
ctmj-148	153	4	sennoside	sennoside	NOUN
ctmj-148	153	5	c	c	PROPN
ctmj-148	153	6	were	be	AUX
ctmj-148	153	7	shown	show	VERB
ctmj-148	153	8	to	to	PART
ctmj-148	153	9	have	have	VERB
ctmj-148	153	10	the	the	DET
ctmj-148	153	11	strongest	strong	ADJ
ctmj-148	153	12	binding	bind	VERB
ctmj-148	153	13	affinities	affinity	NOUN
ctmj-148	153	14	with	with	ADP
ctmj-148	153	15	5	5	NUM
ctmj-148	153	16	-	-	PUNCT
ctmj-148	153	17	ht4	ht4	NOUN
ctmj-148	153	18	of	of	ADP
ctmj-148	153	19	the	the	DET
ctmj-148	153	20	bioactive	bioactive	ADJ
ctmj-148	153	21	derivatives	derivative	NOUN
ctmj-148	153	22	.	.	PUNCT
ctmj-148	154	1	they	they	PRON
ctmj-148	154	2	were	be	AUX
ctmj-148	154	3	predicted	predict	VERB
ctmj-148	154	4	to	to	PART
ctmj-148	154	5	bind	bind	VERB
ctmj-148	154	6	via	via	ADP
ctmj-148	154	7	hydrogen	hydrogen	NOUN
ctmj-148	154	8	bonds	bond	NOUN
ctmj-148	154	9	to	to	ADP
ctmj-148	154	10	the	the	DET
ctmj-148	154	11	asp84	asp84	PROPN
ctmj-148	154	12	,	,	PUNCT
ctmj-148	154	13	val188	val188	PROPN
ctmj-148	154	14	,	,	PUNCT
ctmj-148	154	15	lys174	lys174	PROPN
ctmj-148	154	16	,	,	PUNCT
ctmj-148	154	17	glu80	glu80	NOUN
ctmj-148	154	18	,	,	PUNCT
ctmj-148	154	19	and	and	CCONJ
ctmj-148	154	20	asn279	asn279	NOUN
ctmj-148	154	21	residues	residue	NOUN
ctmj-148	154	22	of	of	ADP
ctmj-148	154	23	5ht4	5ht4	NUM
ctmj-148	154	24	.	.	PUNCT
ctmj-148	155	1	the	the	DET
ctmj-148	155	2	strongest	strong	ADJ
ctmj-148	155	3	predicted	predict	VERB
ctmj-148	155	4	binding	bind	VERB
ctmj-148	155	5	affinity	affinity	NOUN
ctmj-148	155	6	for	for	ADP
ctmj-148	155	7	5	5	NUM
ctmj-148	155	8	-	-	PUNCT
ctmj-148	155	9	ht4	ht4	NOUN
ctmj-148	155	10	was	be	AUX
ctmj-148	155	11	that	that	PRON
ctmj-148	155	12	of	of	ADP
ctmj-148	155	13	sennoside	sennoside	NOUN
ctmj-148	155	14	a	a	DET
ctmj-148	155	15	(	(	PUNCT
ctmj-148	155	16	8.891	8.891	NUM
ctmj-148	155	17	kcal	kcal	NOUN
ctmj-148	155	18	/	/	SYM
ctmj-148	155	19	mol	mol	NOUN
ctmj-148	155	20	)	)	PUNCT
ctmj-148	155	21	.	.	PUNCT
ctmj-148	156	1	the	the	DET
ctmj-148	156	2	five	five	NUM
ctmj-148	156	3	hydrogen	hydrogen	NOUN
ctmj-148	156	4	bonds	bond	NOUN
ctmj-148	156	5	are	be	AUX
ctmj-148	156	6	shown	show	VERB
ctmj-148	156	7	in	in	ADP
ctmj-148	156	8	fig	fig	NOUN
ctmj-148	156	9	.	.	PUNCT
ctmj-148	157	1	5b	5b	NUM
ctmj-148	157	2	:	:	PUNCT
ctmj-148	157	3	the	the	DET
ctmj-148	157	4	oxygen	oxygen	NOUN
ctmj-148	157	5	atom	atom	NOUN
ctmj-148	157	6	at	at	ADP
ctmj-148	157	7	the	the	DET
ctmj-148	157	8	8	8	NUM
ctmj-148	157	9	-	-	PUNCT
ctmj-148	157	10	site	site	NOUN
ctmj-148	157	11	of	of	ADP
ctmj-148	157	12	the	the	DET
ctmj-148	157	13	hydroxyl	hydroxyl	NOUN
ctmj-148	157	14	group	group	NOUN
ctmj-148	157	15	in	in	ADP
ctmj-148	157	16	the	the	DET
ctmj-148	157	17	glucose	glucose	NOUN
ctmj-148	157	18	group	group	NOUN
ctmj-148	157	19	of	of	ADP
ctmj-148	157	20	sennoside	sennoside	NOUN
ctmj-148	157	21	a	a	DET
ctmj-148	157	22	formed	form	VERB
ctmj-148	157	23	a	a	DET
ctmj-148	157	24	hydrogen	hydrogen	NOUN
ctmj-148	157	25	bond	bond	NOUN
ctmj-148	157	26	with	with	ADP
ctmj-148	157	27	the	the	DET
ctmj-148	157	28	glu80	glu80	ADJ
ctmj-148	157	29	and	and	CCONJ
ctmj-148	157	30	asp84	asp84	PROPN
ctmj-148	157	31	residues	residue	NOUN
ctmj-148	157	32	of	of	ADP
ctmj-148	157	33	5	5	NUM
ctmj-148	157	34	-	-	PUNCT
ctmj-148	157	35	ht4	ht4	NOUN
ctmj-148	157	36	,	,	PUNCT
ctmj-148	157	37	separately	separately	ADV
ctmj-148	157	38	.	.	PUNCT
ctmj-148	158	1	in	in	ADP
ctmj-148	158	2	addition	addition	NOUN
ctmj-148	158	3	,	,	PUNCT
ctmj-148	158	4	two	two	NUM
ctmj-148	158	5	oxygen	oxygen	NOUN
ctmj-148	158	6	atoms	atom	NOUN
ctmj-148	158	7	of	of	ADP
ctmj-148	158	8	at	at	ADP
ctmj-148	158	9	the	the	DET
ctmj-148	158	10	80	80	NUM
ctmj-148	158	11	site	site	NOUN
ctmj-148	158	12	of	of	ADP
ctmj-148	158	13	the	the	DET
ctmj-148	158	14	hydroxyl	hydroxyl	NOUN
ctmj-148	158	15	group	group	NOUN
ctmj-148	158	16	in	in	ADP
ctmj-148	158	17	the	the	DET
ctmj-148	158	18	glucose	glucose	NOUN
ctmj-148	158	19	group	group	NOUN
ctmj-148	158	20	connected	connect	VERB
ctmj-148	158	21	with	with	ADP
ctmj-148	158	22	the	the	DET
ctmj-148	158	23	backbone	backbone	NOUN
ctmj-148	158	24	and	and	CCONJ
ctmj-148	158	25	side	side	NOUN
ctmj-148	158	26	-	-	PUNCT
ctmj-148	158	27	chain	chain	NOUN
ctmj-148	158	28	of	of	ADP
ctmj-148	158	29	val188	val188	PROPN
ctmj-148	158	30	,	,	PUNCT
ctmj-148	158	31	and	and	CCONJ
ctmj-148	158	32	the	the	DET
ctmj-148	158	33	oxygen	oxygen	NOUN
ctmj-148	158	34	atom	atom	NOUN
ctmj-148	158	35	at	at	ADP
ctmj-148	158	36	the	the	DET
ctmj-148	158	37	90	90	NUM
ctmj-148	158	38	site	site	NOUN
ctmj-148	158	39	of	of	ADP
ctmj-148	158	40	the	the	DET
ctmj-148	158	41	carbonyl	carbonyl	NOUN
ctmj-148	158	42	group	group	NOUN
ctmj-148	158	43	of	of	ADP
ctmj-148	158	44	sennoside	sennoside	NOUN
ctmj-148	158	45	a	a	DET
ctmj-148	158	46	interacted	interact	VERB
ctmj-148	158	47	with	with	ADP
ctmj-148	158	48	the	the	DET
ctmj-148	158	49	lys174	lys174	PROPN
ctmj-148	158	50	residue	residue	NOUN
ctmj-148	158	51	of	of	ADP
ctmj-148	158	52	5	5	NUM
ctmj-148	158	53	-	-	PUNCT
ctmj-148	158	54	ht4	ht4	NOUN
ctmj-148	158	55	.	.	PUNCT
ctmj-148	159	1	however	however	ADV
ctmj-148	159	2	,	,	PUNCT
ctmj-148	159	3	in	in	ADP
ctmj-148	159	4	contrast	contrast	NOUN
ctmj-148	159	5	to	to	ADP
ctmj-148	159	6	the	the	DET
ctmj-148	159	7	situation	situation	NOUN
ctmj-148	159	8	with	with	ADP
ctmj-148	159	9	c	c	NOUN
ctmj-148	159	10	-	-	PUNCT
ctmj-148	159	11	kit	kit	NOUN
ctmj-148	159	12	and	and	CCONJ
ctmj-148	159	13	5	5	NUM
ctmj-148	159	14	-	-	PUNCT
ctmj-148	159	15	ht4	ht4	NOUN
ctmj-148	159	16	,	,	PUNCT
ctmj-148	159	17	in	in	ADP
ctmj-148	159	18	which	which	PRON
ctmj-148	159	19	the	the	DET
ctmj-148	159	20	bioactive	bioactive	NOUN
ctmj-148	159	21	compounds	compound	NOUN
ctmj-148	159	22	interacted	interact	VERB
ctmj-148	159	23	with	with	ADP
ctmj-148	159	24	amino	amino	NOUN
ctmj-148	159	25	acid	acid	NOUN
ctmj-148	159	26	residues	residue	NOUN
ctmj-148	159	27	via	via	ADP
ctmj-148	159	28	numerous	numerous	ADJ
ctmj-148	159	29	hydrogen	hydrogen	NOUN
ctmj-148	159	30	bonds	bond	NOUN
ctmj-148	159	31	,	,	PUNCT
ctmj-148	159	32	aqp3	aqp3	PROPN
ctmj-148	159	33	was	be	AUX
ctmj-148	159	34	predicted	predict	VERB
ctmj-148	159	35	to	to	PART
ctmj-148	159	36	have	have	VERB
ctmj-148	159	37	few	few	ADJ
ctmj-148	159	38	,	,	PUNCT
ctmj-148	159	39	weak	weak	ADJ
ctmj-148	159	40	interactions	interaction	NOUN
ctmj-148	159	41	with	with	ADP
ctmj-148	159	42	the	the	DET
ctmj-148	159	43	rhubarb	rhubarb	NOUN
ctmj-148	159	44	derivatives	derivative	NOUN
ctmj-148	159	45	.	.	PUNCT
ctmj-148	160	1	the	the	DET
ctmj-148	160	2	strongest	strong	ADJ
ctmj-148	160	3	binding	bind	VERB
ctmj-148	160	4	affinity	affinity	NOUN
ctmj-148	160	5	with	with	ADP
ctmj-148	160	6	aqp3	aqp3	PROPN
ctmj-148	160	7	was	be	AUX
ctmj-148	160	8	shown	show	VERB
ctmj-148	160	9	by	by	ADP
ctmj-148	160	10	physcionanthrone	physcionanthrone	NOUN
ctmj-148	160	11	(	(	PUNCT
ctmj-148	160	12	6.809	6.809	NUM
ctmj-148	160	13	kcal	kcal	NOUN
ctmj-148	160	14	/	/	SYM
ctmj-148	160	15	mol	mol	PROPN
ctmj-148	160	16	):	):	PUNCT
ctmj-148	160	17	the	the	DET
ctmj-148	160	18	oxygen	oxygen	NOUN
ctmj-148	160	19	atom	atom	NOUN
ctmj-148	160	20	at	at	ADP
ctmj-148	160	21	the	the	DET
ctmj-148	160	22	1site	1site	NUM
ctmj-148	160	23	of	of	ADP
ctmj-148	160	24	the	the	DET
ctmj-148	160	25	hydroxyl	hydroxyl	NOUN
ctmj-148	160	26	group	group	NOUN
ctmj-148	160	27	in	in	ADP
ctmj-148	160	28	physcionanthrone	physcionanthrone	PROPN
ctmj-148	160	29	formed	form	VERB
ctmj-148	160	30	a	a	DET
ctmj-148	160	31	hydrogen	hydrogen	NOUN
ctmj-148	160	32	bond	bond	NOUN
ctmj-148	160	33	with	with	ADP
ctmj-148	160	34	the	the	DET
ctmj-148	160	35	ala80	ala80	ADJ
ctmj-148	160	36	residue	residue	NOUN
ctmj-148	160	37	of	of	ADP
ctmj-148	160	38	aqp3	aqp3	PROPN
ctmj-148	160	39	(	(	PUNCT
ctmj-148	160	40	fig	fig	NOUN
ctmj-148	160	41	.	.	PUNCT
ctmj-148	160	42	5c	5c	NUM
ctmj-148	160	43	)	)	PUNCT
ctmj-148	160	44	.	.	PUNCT
ctmj-148	161	1	taken	take	VERB
ctmj-148	161	2	together	together	ADV
ctmj-148	161	3	,	,	PUNCT
ctmj-148	161	4	the	the	DET
ctmj-148	161	5	results	result	NOUN
ctmj-148	161	6	of	of	ADP
ctmj-148	161	7	the	the	DET
ctmj-148	161	8	molecular	molecular	ADJ
ctmj-148	161	9	docking	docking	NOUN
ctmj-148	161	10	modeling	modeling	NOUN
ctmj-148	161	11	showed	show	VERB
ctmj-148	161	12	that	that	SCONJ
ctmj-148	161	13	various	various	ADJ
ctmj-148	161	14	oxygen	oxygen	NOUN
ctmj-148	161	15	atoms	atom	NOUN
ctmj-148	161	16	of	of	ADP
ctmj-148	161	17	basic	basic	ADJ
ctmj-148	161	18	skeletons	skeleton	NOUN
ctmj-148	161	19	and	and	CCONJ
ctmj-148	161	20	glucose	glucose	NOUN
ctmj-148	161	21	groups	group	NOUN
ctmj-148	161	22	of	of	ADP
ctmj-148	161	23	the	the	DET
ctmj-148	161	24	10	10	NUM
ctmj-148	161	25	bioactive	bioactive	ADJ
ctmj-148	161	26	compounds	compound	NOUN
ctmj-148	161	27	derived	derive	VERB
ctmj-148	161	28	from	from	ADP
ctmj-148	161	29	rhubarb	rhubarb	NOUN
ctmj-148	161	30	can	can	AUX
ctmj-148	161	31	form	form	VERB
ctmj-148	161	32	hydrogen	hydrogen	NOUN
ctmj-148	161	33	bonds	bond	NOUN
ctmj-148	161	34	with	with	ADP
ctmj-148	161	35	the	the	DET
ctmj-148	161	36	three	three	NUM
ctmj-148	161	37	molecules	molecule	NOUN
ctmj-148	161	38	that	that	PRON
ctmj-148	161	39	mediate	mediate	VERB
ctmj-148	161	40	laxative	laxative	ADJ
ctmj-148	161	41	effects	effect	NOUN
ctmj-148	161	42	.	.	PUNCT
ctmj-148	162	1	effects	effect	NOUN
ctmj-148	162	2	of	of	ADP
ctmj-148	162	3	rhubarb	rhubarb	NOUN
ctmj-148	162	4	extract	extract	NOUN
ctmj-148	162	5	on	on	ADP
ctmj-148	162	6	the	the	DET
ctmj-148	162	7	expression	expression	NOUN
ctmj-148	162	8	of	of	ADP
ctmj-148	162	9	c	c	NOUN
ctmj-148	162	10	-	-	PUNCT
ctmj-148	162	11	kit	kit	NOUN
ctmj-148	162	12	,	,	PUNCT
ctmj-148	162	13	aqp3	aqp3	PROPN
ctmj-148	162	14	,	,	PUNCT
ctmj-148	162	15	and	and	CCONJ
ctmj-148	162	16	5ht4	5ht4	NUM
ctmj-148	162	17	in	in	ADP
ctmj-148	162	18	the	the	DET
ctmj-148	162	19	colons	colon	NOUN
ctmj-148	162	20	of	of	ADP
ctmj-148	162	21	rats	rat	NOUN
ctmj-148	162	22	in	in	ADP
ctmj-148	162	23	order	order	NOUN
ctmj-148	162	24	to	to	PART
ctmj-148	162	25	increase	increase	VERB
ctmj-148	162	26	the	the	DET
ctmj-148	162	27	biological	biological	ADJ
ctmj-148	162	28	relevance	relevance	NOUN
ctmj-148	162	29	of	of	ADP
ctmj-148	162	30	the	the	DET
ctmj-148	162	31	molecular	molecular	ADJ
ctmj-148	162	32	docking	docking	NOUN
ctmj-148	162	33	data	datum	NOUN
ctmj-148	162	34	,	,	PUNCT
ctmj-148	162	35	the	the	DET
ctmj-148	162	36	effects	effect	NOUN
ctmj-148	162	37	of	of	ADP
ctmj-148	162	38	rhubarb	rhubarb	NOUN
ctmj-148	162	39	extract	extract	NOUN
ctmj-148	162	40	on	on	ADP
ctmj-148	162	41	ckit	ckit	NOUN
ctmj-148	162	42	,	,	PUNCT
ctmj-148	162	43	5	5	NUM
ctmj-148	162	44	-	-	PUNCT
ctmj-148	162	45	ht4	ht4	NOUN
ctmj-148	162	46	,	,	PUNCT
ctmj-148	162	47	and	and	CCONJ
ctmj-148	162	48	aqp3	aqp3	NOUN
ctmj-148	162	49	expression	expression	NOUN
ctmj-148	162	50	were	be	AUX
ctmj-148	162	51	evaluated	evaluate	VERB
ctmj-148	162	52	by	by	ADP
ctmj-148	162	53	western	western	ADJ
ctmj-148	162	54	blot	blot	NOUN
ctmj-148	162	55	analysis	analysis	NOUN
ctmj-148	162	56	.	.	PUNCT
ctmj-148	163	1	colonic	colonic	ADJ
ctmj-148	163	2	lysates	lysate	NOUN
ctmj-148	163	3	prepared	prepare	VERB
ctmj-148	163	4	from	from	ADP
ctmj-148	163	5	rats	rat	NOUN
ctmj-148	163	6	in	in	ADP
ctmj-148	163	7	the	the	DET
ctmj-148	163	8	control	control	NOUN
ctmj-148	163	9	,	,	PUNCT
ctmj-148	163	10	model	model	NOUN
ctmj-148	163	11	,	,	PUNCT
ctmj-148	163	12	and	and	CCONJ
ctmj-148	163	13	treatment	treatment	NOUN
ctmj-148	163	14	groups	group	NOUN
ctmj-148	163	15	were	be	AUX
ctmj-148	163	16	prepared	prepare	VERB
ctmj-148	163	17	and	and	CCONJ
ctmj-148	163	18	immunoblotted	immunoblotte	VERB
ctmj-148	163	19	for	for	ADP
ctmj-148	163	20	each	each	PRON
ctmj-148	163	21	of	of	ADP
ctmj-148	163	22	the	the	DET
ctmj-148	163	23	proteins	protein	NOUN
ctmj-148	163	24	.	.	PUNCT
ctmj-148	164	1	as	as	SCONJ
ctmj-148	164	2	shown	show	VERB
ctmj-148	164	3	in	in	ADP
ctmj-148	164	4	fig	fig	NOUN
ctmj-148	164	5	.	.	PUNCT
ctmj-148	165	1	6	6	NUM
ctmj-148	165	2	,	,	PUNCT
ctmj-148	165	3	the	the	DET
ctmj-148	165	4	expression	expression	NOUN
ctmj-148	165	5	of	of	ADP
ctmj-148	165	6	c	c	NOUN
ctmj-148	165	7	-	-	PUNCT
ctmj-148	165	8	kit	kit	NOUN
ctmj-148	165	9	and	and	CCONJ
ctmj-148	165	10	5	5	NUM
ctmj-148	165	11	-	-	PUNCT
ctmj-148	165	12	ht4	ht4	NOUN
ctmj-148	165	13	was	be	AUX
ctmj-148	165	14	much	much	ADV
ctmj-148	165	15	lower	low	ADJ
ctmj-148	165	16	,	,	PUNCT
ctmj-148	165	17	and	and	CCONJ
ctmj-148	165	18	that	that	PRON
ctmj-148	165	19	of	of	ADP
ctmj-148	165	20	aqp3	aqp3	PROPN
ctmj-148	165	21	was	be	AUX
ctmj-148	165	22	higher	high	ADJ
ctmj-148	165	23	in	in	ADP
ctmj-148	165	24	model	model	NOUN
ctmj-148	165	25	rats	rat	NOUN
ctmj-148	165	26	than	than	ADP
ctmj-148	165	27	in	in	ADP
ctmj-148	165	28	the	the	DET
ctmj-148	165	29	control	control	NOUN
ctmj-148	165	30	group	group	NOUN
ctmj-148	165	31	.	.	PUNCT
ctmj-148	166	1	when	when	SCONJ
ctmj-148	166	2	constipated	constipate	VERB
ctmj-148	166	3	rats	rat	NOUN
ctmj-148	166	4	were	be	AUX
ctmj-148	166	5	treated	treat	VERB
ctmj-148	166	6	with	with	ADP
ctmj-148	166	7	rhubarb	rhubarb	NOUN
ctmj-148	166	8	extract	extract	NOUN
ctmj-148	166	9	,	,	PUNCT
ctmj-148	166	10	these	these	DET
ctmj-148	166	11	changes	change	NOUN
ctmj-148	166	12	in	in	ADP
ctmj-148	166	13	expression	expression	NOUN
ctmj-148	166	14	were	be	AUX
ctmj-148	166	15	all	all	PRON
ctmj-148	166	16	reversed	reverse	VERB
ctmj-148	166	17	.	.	PUNCT
ctmj-148	167	1	the	the	DET
ctmj-148	167	2	increase	increase	NOUN
ctmj-148	167	3	in	in	ADP
ctmj-148	167	4	c	c	NOUN
ctmj-148	167	5	-	-	PUNCT
ctmj-148	167	6	kit	kit	NOUN
ctmj-148	167	7	expression	expression	NOUN
ctmj-148	167	8	in	in	ADP
ctmj-148	167	9	the	the	DET
ctmj-148	167	10	colon	colon	NOUN
ctmj-148	167	11	would	would	AUX
ctmj-148	167	12	tend	tend	VERB
ctmj-148	167	13	to	to	PART
ctmj-148	167	14	maintain	maintain	VERB
ctmj-148	167	15	the	the	DET
ctmj-148	167	16	phenotype	phenotype	NOUN
ctmj-148	167	17	of	of	ADP
ctmj-148	167	18	iccs	iccs	NOUN
ctmj-148	167	19	,	,	PUNCT
ctmj-148	167	20	thereby	thereby	ADV
ctmj-148	167	21	promoting	promote	VERB
ctmj-148	167	22	intestinal	intestinal	ADJ
ctmj-148	167	23	motility.31,32	motility.31,32	NOUN
ctmj-148	167	24	in	in	ADP
ctmj-148	167	25	addition	addition	NOUN
ctmj-148	167	26	,	,	PUNCT
ctmj-148	167	27	the	the	DET
ctmj-148	167	28	fig	fig	NOUN
ctmj-148	167	29	.	.	PUNCT
ctmj-148	168	1	6	6	NUM
ctmj-148	168	2	.	.	PUNCT
ctmj-148	169	1	the	the	DET
ctmj-148	169	2	effects	effect	NOUN
ctmj-148	169	3	of	of	ADP
ctmj-148	169	4	rhubarb	rhubarb	NOUN
ctmj-148	169	5	extract	extract	NOUN
ctmj-148	169	6	on	on	ADP
ctmj-148	169	7	the	the	DET
ctmj-148	169	8	expression	expression	NOUN
ctmj-148	169	9	of	of	ADP
ctmj-148	169	10	c	c	NOUN
ctmj-148	169	11	-	-	PUNCT
ctmj-148	169	12	kit	kit	NOUN
ctmj-148	169	13	,	,	PUNCT
ctmj-148	169	14	5	5	NUM
ctmj-148	169	15	-	-	PUNCT
ctmj-148	169	16	ht4	ht4	NOUN
ctmj-148	169	17	,	,	PUNCT
ctmj-148	169	18	and	and	CCONJ
ctmj-148	169	19	aqp3	aqp3	VERB
ctmj-148	169	20	in	in	ADP
ctmj-148	169	21	the	the	DET
ctmj-148	169	22	colons	colon	NOUN
ctmj-148	169	23	of	of	ADP
ctmj-148	169	24	rats	rat	NOUN
ctmj-148	169	25	(	(	PUNCT
ctmj-148	169	26	a	a	X
ctmj-148	169	27	)	)	PUNCT
ctmj-148	169	28	c	c	NOUN
ctmj-148	169	29	-	-	PUNCT
ctmj-148	169	30	kit	kit	NOUN
ctmj-148	169	31	,	,	PUNCT
ctmj-148	169	32	5	5	NUM
ctmj-148	169	33	-	-	PUNCT
ctmj-148	169	34	ht4	ht4	NOUN
ctmj-148	169	35	,	,	PUNCT
ctmj-148	169	36	and	and	CCONJ
ctmj-148	169	37	aqp3	aqp3	NOUN
ctmj-148	169	38	protein	protein	NOUN
ctmj-148	169	39	expression	expression	NOUN
ctmj-148	169	40	in	in	ADP
ctmj-148	169	41	the	the	DET
ctmj-148	169	42	colon	colon	NOUN
ctmj-148	169	43	,	,	PUNCT
ctmj-148	169	44	measured	measure	VERB
ctmj-148	169	45	using	use	VERB
ctmj-148	169	46	western	western	ADJ
ctmj-148	169	47	blotting	blotting	NOUN
ctmj-148	169	48	(	(	PUNCT
ctmj-148	169	49	bed	bed	NOUN
ctmj-148	169	50	):	):	PUNCT
ctmj-148	169	51	c	c	NOUN
ctmj-148	169	52	-	-	PUNCT
ctmj-148	169	53	kit	kit	NOUN
ctmj-148	169	54	,	,	PUNCT
ctmj-148	169	55	5	5	NUM
ctmj-148	169	56	-	-	PUNCT
ctmj-148	169	57	ht4	ht4	NOUN
ctmj-148	169	58	,	,	PUNCT
ctmj-148	169	59	and	and	CCONJ
ctmj-148	169	60	aqp3	aqp3	NOUN
ctmj-148	169	61	protein	protein	NOUN
ctmj-148	169	62	expression	expression	NOUN
ctmj-148	169	63	,	,	PUNCT
ctmj-148	169	64	normalized	normalize	VERB
ctmj-148	169	65	to	to	ADP
ctmj-148	169	66	that	that	PRON
ctmj-148	169	67	of	of	ADP
ctmj-148	169	68	gapdh	gapdh	NOUN
ctmj-148	169	69	,	,	PUNCT
ctmj-148	169	70	respectively	respectively	ADV
ctmj-148	169	71	.	.	PUNCT
ctmj-148	170	1	note	note	NOUN
ctmj-148	170	2	:	:	PUNCT
ctmj-148	170	3	5	5	NUM
ctmj-148	170	4	-	-	PUNCT
ctmj-148	170	5	ht4	ht4	NOUN
ctmj-148	170	6	:	:	PUNCT
ctmj-148	170	7	5	5	NUM
ctmj-148	170	8	-	-	PUNCT
ctmj-148	170	9	hydroxytryptamine	hydroxytryptamine	NOUN
ctmj-148	170	10	receptor	receptor	NOUN
ctmj-148	170	11	4	4	NUM
ctmj-148	170	12	;	;	PUNCT
ctmj-148	170	13	aqp3	aqp3	PROPN
ctmj-148	170	14	:	:	PUNCT
ctmj-148	170	15	aquaporin-3	aquaporin-3	NOUN
ctmj-148	170	16	;	;	PUNCT
ctmj-148	170	17	gapdh	gapdh	NOUN
ctmj-148	170	18	:	:	PUNCT
ctmj-148	170	19	glyceraldehyde	glyceraldehyde	NOUN
ctmj-148	170	20	3	3	NUM
ctmj-148	170	21	-	-	PUNCT
ctmj-148	170	22	phosphate	phosphate	NOUN
ctmj-148	170	23	dehydrogenase	dehydrogenase	NOUN
ctmj-148	170	24	.	.	PUNCT
ctmj-148	171	1	data	datum	NOUN
ctmj-148	171	2	are	be	AUX
ctmj-148	171	3	expressed	express	VERB
ctmj-148	171	4	as	as	ADP
ctmj-148	171	5	mean	mean	NOUN
ctmj-148	171	6	(	(	PUNCT
ctmj-148	171	7	sem	sem	NOUN
ctmj-148	171	8	)	)	PUNCT
ctmj-148	171	9	.	.	PUNCT
ctmj-148	172	1	n	n	PRON
ctmj-148	172	2	¼	¼	NOUN
ctmj-148	172	3	3	3	NUM
ctmj-148	172	4	.	.	PUNCT
ctmj-148	173	1	*	*	PUNCT
ctmj-148	173	2	p	p	X
ctmj-148	173	3	<	<	X
ctmj-148	173	4	.05	.05	NUM
ctmj-148	173	5	,	,	PUNCT
ctmj-148	173	6	*	*	PUNCT
ctmj-148	173	7	*	*	PUNCT
ctmj-148	173	8	p	p	X
ctmj-148	173	9	<	<	X
ctmj-148	173	10	.01	.01	NUM
ctmj-148	173	11	vs.	vs.	ADP
ctmj-148	173	12	the	the	DET
ctmj-148	173	13	control	control	NOUN
ctmj-148	173	14	group	group	NOUN
ctmj-148	173	15	.	.	PUNCT
ctmj-148	174	1	ctmj	ctmj	PROPN
ctmj-148	175	1	|	|	ADV
ctmj-148	175	2	traditionalmedicinejournals.com	traditionalmedicinejournals.com	X
ctmj-148	175	3	issn	issn	PROPN
ctmj-148	175	4	:	:	PUNCT
ctmj-148	175	5	2693	2693	NUM
ctmj-148	175	6	6356	6356	NUM
ctmj-148	175	7	2024	2024	NUM
ctmj-148	175	8	|	|	ADV
ctmj-148	175	9	vol	vol	NOUN
ctmj-148	175	10	7	7	NUM
ctmj-148	175	11	|	|	NOUN
ctmj-148	175	12	issue	issue	VERB
ctmj-148	175	13	1	1	NUM
ctmj-148	175	14	fig	fig	NOUN
ctmj-148	175	15	.	.	PUNCT
ctmj-148	176	1	7	7	X
ctmj-148	176	2	.	.	X
ctmj-148	176	3	potential	potential	ADJ
ctmj-148	176	4	metabolic	metabolic	NOUN
ctmj-148	176	5	pathways	pathway	NOUN
ctmj-148	176	6	for	for	ADP
ctmj-148	176	7	the	the	DET
ctmj-148	176	8	anthraquinones	anthraquinone	NOUN
ctmj-148	176	9	and	and	CCONJ
ctmj-148	176	10	anthrones	anthrone	NOUN
ctmj-148	176	11	(	(	PUNCT
ctmj-148	176	12	aec	aec	NOUN
ctmj-148	176	13	)	)	PUNCT
ctmj-148	176	14	biotransformation	biotransformation	NOUN
ctmj-148	176	15	of	of	ADP
ctmj-148	176	16	emodin	emodin	PROPN
ctmj-148	176	17	,	,	PUNCT
ctmj-148	176	18	sennoside	sennoside	VERB
ctmj-148	176	19	a	a	PRON
ctmj-148	176	20	,	,	PUNCT
ctmj-148	176	21	and	and	CCONJ
ctmj-148	176	22	rhein	rhein	NOUN
ctmj-148	176	23	as	as	ADP
ctmj-148	176	24	a	a	DET
ctmj-148	176	25	product	product	NOUN
ctmj-148	176	26	of	of	ADP
ctmj-148	176	27	the	the	DET
ctmj-148	176	28	metabolism	metabolism	NOUN
ctmj-148	176	29	of	of	ADP
ctmj-148	176	30	various	various	ADJ
ctmj-148	176	31	prototype	prototype	NOUN
ctmj-148	176	32	compounds	compound	NOUN
ctmj-148	176	33	.	.	PUNCT
ctmj-148	177	1	the	the	DET
ctmj-148	177	2	prototype	prototype	NOUN
ctmj-148	177	3	components	component	NOUN
ctmj-148	177	4	are	be	AUX
ctmj-148	177	5	shown	show	VERB
ctmj-148	177	6	in	in	ADP
ctmj-148	177	7	red	red	ADJ
ctmj-148	177	8	and	and	CCONJ
ctmj-148	177	9	the	the	DET
ctmj-148	177	10	active	active	ADJ
ctmj-148	177	11	metabolites	metabolite	NOUN
ctmj-148	177	12	are	be	AUX
ctmj-148	177	13	shown	show	VERB
ctmj-148	177	14	in	in	ADP
ctmj-148	177	15	blue	blue	ADJ
ctmj-148	177	16	.	.	PUNCT
ctmj-148	178	1	increase	increase	VERB
ctmj-148	178	2	in	in	ADP
ctmj-148	178	3	5	5	NUM
ctmj-148	178	4	-	-	PUNCT
ctmj-148	178	5	ht4	ht4	NOUN
ctmj-148	178	6	expression	expression	NOUN
ctmj-148	178	7	in	in	ADP
ctmj-148	178	8	the	the	DET
ctmj-148	178	9	colon	colon	NOUN
ctmj-148	178	10	would	would	AUX
ctmj-148	178	11	be	be	AUX
ctmj-148	178	12	expected	expect	VERB
ctmj-148	178	13	to	to	PART
ctmj-148	178	14	increase	increase	VERB
ctmj-148	178	15	intestinal	intestinal	ADJ
ctmj-148	178	16	transport.11,33,34	transport.11,33,34	NOUN
ctmj-148	178	17	finally	finally	ADV
ctmj-148	178	18	,	,	PUNCT
ctmj-148	178	19	and	and	CCONJ
ctmj-148	178	20	as	as	SCONJ
ctmj-148	178	21	expected	expect	VERB
ctmj-148	178	22	,	,	PUNCT
ctmj-148	178	23	lower	low	ADJ
ctmj-148	178	24	expression	expression	NOUN
ctmj-148	178	25	of	of	ADP
ctmj-148	178	26	aqp3	aqp3	PROPN
ctmj-148	178	27	was	be	AUX
ctmj-148	178	28	shown	show	VERB
ctmj-148	178	29	in	in	ADP
ctmj-148	178	30	the	the	DET
ctmj-148	178	31	colon	colon	NOUN
ctmj-148	178	32	of	of	ADP
ctmj-148	178	33	treated	treat	VERB
ctmj-148	178	34	rats	rat	NOUN
ctmj-148	178	35	,	,	PUNCT
ctmj-148	178	36	which	which	PRON
ctmj-148	178	37	would	would	AUX
ctmj-148	178	38	be	be	AUX
ctmj-148	178	39	expected	expect	VERB
ctmj-148	178	40	to	to	PART
ctmj-148	178	41	inhibit	inhibit	VERB
ctmj-148	178	42	water	water	NOUN
ctmj-148	178	43	absorption	absorption	NOUN
ctmj-148	178	44	,	,	PUNCT
ctmj-148	178	45	which	which	PRON
ctmj-148	178	46	would	would	AUX
ctmj-148	178	47	also	also	ADV
ctmj-148	178	48	have	have	VERB
ctmj-148	178	49	a	a	DET
ctmj-148	178	50	laxative	laxative	NOUN
ctmj-148	178	51	effect.35‒37	effect.35‒37	NOUN
ctmj-148	178	52	thus	thus	ADV
ctmj-148	178	53	,	,	PUNCT
ctmj-148	178	54	rhubarb	rhubarb	NOUN
ctmj-148	178	55	extract	extract	NOUN
ctmj-148	178	56	regulates	regulate	VERB
ctmj-148	178	57	the	the	DET
ctmj-148	178	58	expression	expression	NOUN
ctmj-148	178	59	of	of	ADP
ctmj-148	178	60	the	the	DET
ctmj-148	178	61	identified	identify	VERB
ctmj-148	178	62	potential	potential	ADJ
ctmj-148	178	63	mediators	mediator	NOUN
ctmj-148	178	64	of	of	ADP
ctmj-148	178	65	a	a	DET
ctmj-148	178	66	laxative	laxative	ADJ
ctmj-148	178	67	effect	effect	NOUN
ctmj-148	178	68	.	.	PUNCT
ctmj-148	179	1	fig	fig	NOUN
ctmj-148	179	2	.	.	PUNCT
ctmj-148	180	1	8	8	X
ctmj-148	180	2	.	.	PUNCT
ctmj-148	181	1	network	network	NOUN
ctmj-148	181	2	describing	describe	VERB
ctmj-148	181	3	the	the	DET
ctmj-148	181	4	prototype	prototype	NOUN
ctmj-148	181	5	components	component	NOUN
ctmj-148	181	6	of	of	ADP
ctmj-148	181	7	rhubarb	rhubarb	NOUN
ctmj-148	181	8	,	,	PUNCT
ctmj-148	181	9	their	their	PRON
ctmj-148	181	10	colonic	colonic	ADJ
ctmj-148	181	11	derivatives	derivative	NOUN
ctmj-148	181	12	,	,	PUNCT
ctmj-148	181	13	and	and	CCONJ
ctmj-148	181	14	the	the	DET
ctmj-148	181	15	endogenous	endogenous	ADJ
ctmj-148	181	16	molecular	molecular	ADJ
ctmj-148	181	17	targets	target	NOUN
ctmj-148	181	18	potentially	potentially	ADV
ctmj-148	181	19	mediating	mediate	VERB
ctmj-148	181	20	a	a	DET
ctmj-148	181	21	laxative	laxative	ADJ
ctmj-148	181	22	effect	effect	NOUN
ctmj-148	181	23	.	.	PUNCT
ctmj-148	182	1	the	the	DET
ctmj-148	182	2	prototype	prototype	NOUN
ctmj-148	182	3	components	component	NOUN
ctmj-148	182	4	are	be	AUX
ctmj-148	182	5	shown	show	VERB
ctmj-148	182	6	in	in	ADP
ctmj-148	182	7	pink	pink	ADJ
ctmj-148	182	8	and	and	CCONJ
ctmj-148	182	9	the	the	DET
ctmj-148	182	10	rhubarb	rhubarb	NOUN
ctmj-148	182	11	-	-	PUNCT
ctmj-148	182	12	derived	derive	VERB
ctmj-148	182	13	components	component	NOUN
ctmj-148	182	14	present	present	ADJ
ctmj-148	182	15	in	in	ADP
ctmj-148	182	16	the	the	DET
ctmj-148	182	17	colorectum	colorectum	NOUN
ctmj-148	182	18	are	be	AUX
ctmj-148	182	19	shown	show	VERB
ctmj-148	182	20	in	in	ADP
ctmj-148	182	21	blue	blue	ADJ
ctmj-148	182	22	.	.	PUNCT
ctmj-148	183	1	tracing	trace	VERB
ctmj-148	183	2	of	of	ADP
ctmj-148	183	3	the	the	DET
ctmj-148	183	4	candidate	candidate	NOUN
ctmj-148	183	5	bioactive	bioactive	VERB
ctmj-148	183	6	derivatives	derivative	NOUN
ctmj-148	183	7	back	back	ADV
ctmj-148	183	8	to	to	ADP
ctmj-148	183	9	the	the	DET
ctmj-148	183	10	components	component	NOUN
ctmj-148	183	11	of	of	ADP
ctmj-148	183	12	rhubarb	rhubarb	NOUN
ctmj-148	183	13	to	to	PART
ctmj-148	183	14	trace	trace	VERB
ctmj-148	183	15	the	the	DET
ctmj-148	183	16	biotransformation	biotransformation	NOUN
ctmj-148	183	17	products	product	NOUN
ctmj-148	183	18	to	to	ADP
ctmj-148	183	19	its	its	PRON
ctmj-148	183	20	prototype	prototype	NOUN
ctmj-148	183	21	,	,	PUNCT
ctmj-148	183	22	we	we	PRON
ctmj-148	183	23	explored	explore	VERB
ctmj-148	183	24	the	the	DET
ctmj-148	183	25	in	in	ADP
ctmj-148	183	26	vivo	vivo	ADJ
ctmj-148	183	27	metabolic	metabolic	NOUN
ctmj-148	183	28	transformation	transformation	NOUN
ctmj-148	183	29	of	of	ADP
ctmj-148	183	30	the	the	DET
ctmj-148	183	31	compounds	compound	NOUN
ctmj-148	183	32	in	in	ADP
ctmj-148	183	33	rhubarb	rhubarb	NOUN
ctmj-148	183	34	.	.	PUNCT
ctmj-148	184	1	we	we	PRON
ctmj-148	184	2	studied	study	VERB
ctmj-148	184	3	the	the	DET
ctmj-148	184	4	metabolism	metabolism	NOUN
ctmj-148	184	5	of	of	ADP
ctmj-148	184	6	10	10	NUM
ctmj-148	184	7	representative	representative	ADJ
ctmj-148	184	8	compounds	compound	NOUN
ctmj-148	184	9	,	,	PUNCT
ctmj-148	184	10	including	include	VERB
ctmj-148	184	11	both	both	DET
ctmj-148	184	12	anthraquinones	anthraquinone	NOUN
ctmj-148	184	13	(	(	PUNCT
ctmj-148	184	14	emodin	emodin	NOUN
ctmj-148	184	15	,	,	PUNCT
ctmj-148	184	16	rhein	rhein	NOUN
ctmj-148	184	17	,	,	PUNCT
ctmj-148	184	18	physcion	physcion	NOUN
ctmj-148	184	19	,	,	PUNCT
ctmj-148	184	20	aloe	aloe	PROPN
ctmj-148	184	21	-	-	PUNCT
ctmj-148	184	22	emodin	emodin	PROPN
ctmj-148	184	23	,	,	PUNCT
ctmj-148	184	24	chrysophanol	chrysophanol	NOUN
ctmj-148	184	25	,	,	PUNCT
ctmj-148	184	26	emodin-8	emodin-8	NUM
ctmj-148	184	27	-	-	PUNCT
ctmj-148	184	28	o	o	NOUN
ctmj-148	184	29	-	-	PUNCT
ctmj-148	184	30	b	b	NOUN
ctmj-148	184	31	-	-	PUNCT
ctmj-148	184	32	d	d	NOUN
ctmj-148	184	33	-	-	PUNCT
ctmj-148	184	34	glucopyranoside	glucopyranoside	NOUN
ctmj-148	184	35	,	,	PUNCT
ctmj-148	184	36	aloe	aloe	NOUN
ctmj-148	184	37	-	-	PUNCT
ctmj-148	184	38	emodin-8	emodin-8	NUM
ctmj-148	184	39	-	-	PUNCT
ctmj-148	184	40	o	o	NOUN
ctmj-148	184	41	-	-	PUNCT
ctmj-148	184	42	b	b	NOUN
ctmj-148	184	43	-	-	PUNCT
ctmj-148	184	44	dglucopyranoside	dglucopyranoside	NOUN
ctmj-148	184	45	)	)	PUNCT
ctmj-148	184	46	and	and	CCONJ
ctmj-148	184	47	anthrones	anthrone	NOUN
ctmj-148	184	48	(	(	PUNCT
ctmj-148	184	49	sennoside	sennoside	VERB
ctmj-148	184	50	a	a	DET
ctmj-148	184	51	,	,	PUNCT
ctmj-148	184	52	sennoside	sennoside	NOUN
ctmj-148	184	53	b	b	NOUN
ctmj-148	184	54	,	,	PUNCT
ctmj-148	184	55	and	and	CCONJ
ctmj-148	184	56	sennoside	sennoside	NOUN
ctmj-148	184	57	c	c	PROPN
ctmj-148	184	58	)	)	PUNCT
ctmj-148	184	59	.	.	PUNCT
ctmj-148	185	1	as	as	SCONJ
ctmj-148	185	2	shown	show	VERB
ctmj-148	185	3	in	in	ADP
ctmj-148	185	4	fig	fig	NOUN
ctmj-148	185	5	.	.	PUNCT
ctmj-148	186	1	7a	7a	NUM
ctmj-148	186	2	,	,	PUNCT
ctmj-148	186	3	anthraquinone	anthraquinone	NOUN
ctmj-148	186	4	-	-	PUNCT
ctmj-148	186	5	type	type	NOUN
ctmj-148	186	6	components	component	NOUN
ctmj-148	186	7	are	be	AUX
ctmj-148	186	8	metabolized	metabolize	VERB
ctmj-148	186	9	to	to	ADP
ctmj-148	186	10	glycosides	glycoside	NOUN
ctmj-148	186	11	in	in	ADP
ctmj-148	186	12	vivo	vivo	NOUN
ctmj-148	186	13	,	,	PUNCT
ctmj-148	186	14	and	and	CCONJ
ctmj-148	186	15	the	the	DET
ctmj-148	186	16	principal	principal	ADJ
ctmj-148	186	17	metabolic	metabolic	NOUN
ctmj-148	186	18	pathways	pathway	NOUN
ctmj-148	186	19	involved	involve	VERB
ctmj-148	186	20	are	be	AUX
ctmj-148	186	21	hydroxylation	hydroxylation	NOUN
ctmj-148	186	22	,	,	PUNCT
ctmj-148	186	23	methylation	methylation	NOUN
ctmj-148	186	24	,	,	PUNCT
ctmj-148	186	25	glucuronidation	glucuronidation	NOUN
ctmj-148	186	26	,	,	PUNCT
ctmj-148	186	27	and	and	CCONJ
ctmj-148	186	28	sulfonation	sulfonation	NOUN
ctmj-148	186	29	.	.	PUNCT
ctmj-148	187	1	for	for	ADP
ctmj-148	187	2	anthronetype	anthronetype	NOUN
ctmj-148	187	3	compounds	compound	NOUN
ctmj-148	187	4	(	(	PUNCT
ctmj-148	187	5	fig	fig	NOUN
ctmj-148	187	6	.	.	PUNCT
ctmj-148	187	7	7b	7b	NOUN
ctmj-148	187	8	)	)	PUNCT
ctmj-148	187	9	,	,	PUNCT
ctmj-148	187	10	the	the	DET
ctmj-148	187	11	glucose	glucose	NOUN
ctmj-148	187	12	group	group	NOUN
ctmj-148	187	13	is	be	AUX
ctmj-148	187	14	typically	typically	ADV
ctmj-148	187	15	lost	lose	VERB
ctmj-148	187	16	as	as	ADP
ctmj-148	187	17	a	a	DET
ctmj-148	187	18	result	result	NOUN
ctmj-148	187	19	of	of	ADP
ctmj-148	187	20	hydrolysis	hydrolysis	NOUN
ctmj-148	187	21	.	.	PUNCT
ctmj-148	188	1	in	in	ADP
ctmj-148	188	2	addition	addition	NOUN
ctmj-148	188	3	,	,	PUNCT
ctmj-148	188	4	it	it	PRON
ctmj-148	188	5	was	be	AUX
ctmj-148	188	6	predicted	predict	VERB
ctmj-148	188	7	that	that	SCONJ
ctmj-148	188	8	anthrone	anthrone	NOUN
ctmj-148	188	9	-	-	PUNCT
ctmj-148	188	10	type	type	NOUN
ctmj-148	188	11	compounds	compound	NOUN
ctmj-148	188	12	would	would	AUX
ctmj-148	188	13	principally	principally	ADV
ctmj-148	188	14	undergo	undergo	VERB
ctmj-148	188	15	c10ec10	c10ec10	PROPN
ctmj-148	188	16	’	'	PUNCT
ctmj-148	188	17	bond	bond	NOUN
ctmj-148	188	18	cleavage	cleavage	NOUN
ctmj-148	188	19	in	in	ADP
ctmj-148	188	20	vivo	vivo	NOUN
ctmj-148	188	21	and	and	CCONJ
ctmj-148	188	22	be	be	AUX
ctmj-148	188	23	further	far	ADV
ctmj-148	188	24	metabolized	metabolize	VERB
ctmj-148	188	25	to	to	ADP
ctmj-148	188	26	anthraquinone	anthraquinone	NOUN
ctmj-148	188	27	-	-	PUNCT
ctmj-148	188	28	type	type	NOUN
ctmj-148	188	29	metabolites	metabolite	NOUN
ctmj-148	188	30	.	.	PUNCT
ctmj-148	189	1	overall	overall	ADJ
ctmj-148	189	2	,	,	PUNCT
ctmj-148	189	3	similar	similar	ADJ
ctmj-148	189	4	metabolic	metabolic	NOUN
ctmj-148	189	5	patterns	pattern	NOUN
ctmj-148	189	6	were	be	AUX
ctmj-148	189	7	predicted	predict	VERB
ctmj-148	189	8	for	for	ADP
ctmj-148	189	9	the	the	DET
ctmj-148	189	10	10	10	NUM
ctmj-148	189	11	representative	representative	ADJ
ctmj-148	189	12	compounds	compound	NOUN
ctmj-148	189	13	.	.	PUNCT
ctmj-148	190	1	we	we	PRON
ctmj-148	190	2	found	find	VERB
ctmj-148	190	3	that	that	SCONJ
ctmj-148	190	4	a	a	DET
ctmj-148	190	5	prototype	prototype	NOUN
ctmj-148	190	6	component	component	NOUN
ctmj-148	190	7	,	,	PUNCT
ctmj-148	190	8	for	for	ADP
ctmj-148	190	9	instance	instance	NOUN
ctmj-148	190	10	sennoside	sennoside	NOUN
ctmj-148	190	11	a	a	DET
ctmj-148	190	12	(	(	PUNCT
ctmj-148	190	13	fig	fig	NOUN
ctmj-148	190	14	.	.	PUNCT
ctmj-148	191	1	7b	7b	NOUN
ctmj-148	191	2	)	)	PUNCT
ctmj-148	191	3	,	,	PUNCT
ctmj-148	191	4	may	may	AUX
ctmj-148	191	5	be	be	AUX
ctmj-148	191	6	metabolized	metabolize	VERB
ctmj-148	191	7	to	to	PART
ctmj-148	191	8	form	form	VERB
ctmj-148	191	9	several	several	ADJ
ctmj-148	191	10	active	active	ADJ
ctmj-148	191	11	metabolites	metabolite	NOUN
ctmj-148	191	12	(	(	PUNCT
ctmj-148	191	13	rheinanthrone	rheinanthrone	NOUN
ctmj-148	191	14	,	,	PUNCT
ctmj-148	191	15	emodin	emodin	PROPN
ctmj-148	191	16	,	,	PUNCT
ctmj-148	191	17	chrysophanol	chrysophanol	NOUN
ctmj-148	191	18	,	,	PUNCT
ctmj-148	191	19	aloe	aloe	PROPN
ctmj-148	191	20	-	-	PUNCT
ctmj-148	191	21	emodin	emodin	PROPN
ctmj-148	191	22	,	,	PUNCT
ctmj-148	191	23	rhein	rhein	NOUN
ctmj-148	191	24	,	,	PUNCT
ctmj-148	191	25	and	and	CCONJ
ctmj-148	191	26	physcion	physcion	NOUN
ctmj-148	191	27	)	)	PUNCT
ctmj-148	191	28	,	,	PUNCT
ctmj-148	191	29	and	and	CCONJ
ctmj-148	191	30	a	a	DET
ctmj-148	191	31	single	single	ADJ
ctmj-148	191	32	bioactive	bioactive	NOUN
ctmj-148	191	33	molecule	molecule	NOUN
ctmj-148	191	34	,	,	PUNCT
ctmj-148	191	35	such	such	ADJ
ctmj-148	191	36	as	as	ADP
ctmj-148	191	37	rhein	rhein	NOUN
ctmj-148	191	38	(	(	PUNCT
ctmj-148	191	39	fig	fig	NOUN
ctmj-148	191	40	.	.	PUNCT
ctmj-148	191	41	7c	7c	NUM
ctmj-148	191	42	)	)	PUNCT
ctmj-148	191	43	,	,	PUNCT
ctmj-148	191	44	can	can	AUX
ctmj-148	191	45	also	also	ADV
ctmj-148	191	46	be	be	AUX
ctmj-148	191	47	generated	generate	VERB
ctmj-148	191	48	from	from	ADP
ctmj-148	191	49	various	various	ADJ
ctmj-148	191	50	prototype	prototype	NOUN
ctmj-148	191	51	compounds	compound	NOUN
ctmj-148	191	52	(	(	PUNCT
ctmj-148	191	53	sennoside	sennoside	NOUN
ctmj-148	191	54	a	a	DET
ctmj-148	191	55	,	,	PUNCT
ctmj-148	191	56	sennoside	sennoside	NOUN
ctmj-148	191	57	b	b	NOUN
ctmj-148	191	58	,	,	PUNCT
ctmj-148	191	59	sennoside	sennoside	NOUN
ctmj-148	191	60	c	c	NOUN
ctmj-148	191	61	,	,	PUNCT
ctmj-148	191	62	physcion	physcion	NOUN
ctmj-148	192	1	[	[	X
ctmj-148	192	2	10	10	NUM
ctmj-148	192	3	/	/	SYM
ctmj-148	192	4	100	100	NUM
ctmj-148	192	5	]	]	PUNCT
ctmj-148	192	6	rhein	rhein	NOUN
ctmj-148	192	7	type	type	NOUN
ctmj-148	192	8	aglycone	aglycone	NOUN
ctmj-148	192	9	,	,	PUNCT
ctmj-148	192	10	chrysophanol	chrysophanol	NOUN
ctmj-148	192	11	[	[	X
ctmj-148	192	12	10	10	NUM
ctmj-148	192	13	/	/	SYM
ctmj-148	192	14	100	100	NUM
ctmj-148	192	15	]	]	PUNCT
ctmj-148	192	16	rhein	rhein	NOUN
ctmj-148	192	17	type	type	NOUN
ctmj-148	192	18	aglycone	aglycone	NOUN
ctmj-148	192	19	,	,	PUNCT
ctmj-148	192	20	aloeemodin	aloeemodin	NOUN
ctmj-148	192	21	,	,	PUNCT
ctmj-148	192	22	emodin	emodin	NOUN
ctmj-148	192	23	,	,	PUNCT
ctmj-148	192	24	physcion	physcion	NOUN
ctmj-148	192	25	,	,	PUNCT
ctmj-148	192	26	and	and	CCONJ
ctmj-148	192	27	chrysophanol	chrysophanol	NOUN
ctmj-148	192	28	)	)	PUNCT
ctmj-148	192	29	.	.	PUNCT
ctmj-148	193	1	finally	finally	ADV
ctmj-148	193	2	,	,	PUNCT
ctmj-148	193	3	using	use	VERB
ctmj-148	193	4	this	this	DET
ctmj-148	193	5	information	information	NOUN
ctmj-148	193	6	regarding	regard	VERB
ctmj-148	193	7	the	the	DET
ctmj-148	193	8	likely	likely	ADJ
ctmj-148	193	9	metabolic	metabolic	NOUN
ctmj-148	193	10	pathways	pathway	NOUN
ctmj-148	193	11	involved	involve	VERB
ctmj-148	193	12	,	,	PUNCT
ctmj-148	193	13	the	the	DET
ctmj-148	193	14	active	active	ADJ
ctmj-148	193	15	compounds	compound	NOUN
ctmj-148	193	16	identified	identify	VERB
ctmj-148	193	17	in	in	ADP
ctmj-148	193	18	colorectal	colorectal	ADJ
ctmj-148	193	19	contents	content	NOUN
ctmj-148	193	20	were	be	AUX
ctmj-148	193	21	traced	trace	VERB
ctmj-148	193	22	back	back	ADV
ctmj-148	193	23	to	to	ADP
ctmj-148	193	24	the	the	DET
ctmj-148	193	25	prototype	prototype	NOUN
ctmj-148	193	26	components	component	NOUN
ctmj-148	193	27	of	of	ADP
ctmj-148	193	28	rhubarb	rhubarb	NOUN
ctmj-148	193	29	.	.	PUNCT
ctmj-148	194	1	as	as	SCONJ
ctmj-148	194	2	shown	show	VERB
ctmj-148	194	3	in	in	ADP
ctmj-148	194	4	fig	fig	NOUN
ctmj-148	194	5	.	.	PUNCT
ctmj-148	195	1	8	8	NUM
ctmj-148	195	2	,	,	PUNCT
ctmj-148	195	3	anthraquinone	anthraquinone	NOUN
ctmj-148	195	4	derivatives	derivative	NOUN
ctmj-148	195	5	,	,	PUNCT
ctmj-148	195	6	anthrone	anthrone	NOUN
ctmj-148	195	7	derivatives	derivative	NOUN
ctmj-148	195	8	,	,	PUNCT
ctmj-148	195	9	and	and	CCONJ
ctmj-148	195	10	their	their	PRON
ctmj-148	195	11	glucosides	glucoside	NOUN
ctmj-148	195	12	in	in	ADP
ctmj-148	195	13	rhubarb	rhubarb	NOUN
ctmj-148	195	14	can	can	AUX
ctmj-148	195	15	all	all	PRON
ctmj-148	195	16	be	be	AUX
ctmj-148	195	17	metabolized	metabolize	VERB
ctmj-148	195	18	to	to	PART
ctmj-148	195	19	generate	generate	VERB
ctmj-148	195	20	the	the	DET
ctmj-148	195	21	10	10	NUM
ctmj-148	195	22	potentially	potentially	ADV
ctmj-148	195	23	bioactive	bioactive	ADJ
ctmj-148	195	24	compounds	compound	NOUN
ctmj-148	195	25	identified	identify	VERB
ctmj-148	195	26	,	,	PUNCT
ctmj-148	195	27	which	which	PRON
ctmj-148	195	28	have	have	VERB
ctmj-148	195	29	the	the	DET
ctmj-148	195	30	potential	potential	NOUN
ctmj-148	195	31	to	to	PART
ctmj-148	195	32	provide	provide	VERB
ctmj-148	195	33	three	three	NUM
ctmj-148	195	34	complementary	complementary	ADJ
ctmj-148	195	35	molecular	molecular	ADJ
ctmj-148	195	36	mechanisms	mechanism	NOUN
ctmj-148	195	37	for	for	ADP
ctmj-148	195	38	the	the	DET
ctmj-148	195	39	laxative	laxative	ADJ
ctmj-148	195	40	effect	effect	NOUN
ctmj-148	195	41	.	.	PUNCT
ctmj-148	196	1	discussion	discussion	NOUN
ctmj-148	196	2	in	in	ADP
ctmj-148	196	3	the	the	DET
ctmj-148	196	4	present	present	ADJ
ctmj-148	196	5	study	study	NOUN
ctmj-148	196	6	,	,	PUNCT
ctmj-148	196	7	we	we	PRON
ctmj-148	196	8	have	have	AUX
ctmj-148	196	9	used	use	VERB
ctmj-148	196	10	an	an	DET
ctmj-148	196	11	ms	ms	PROPN
ctmj-148	196	12	-	-	PUNCT
ctmj-148	196	13	based	base	VERB
ctmj-148	196	14	approach	approach	NOUN
ctmj-148	196	15	and	and	CCONJ
ctmj-148	196	16	molecular	molecular	ADJ
ctmj-148	196	17	modeling	modeling	NOUN
ctmj-148	196	18	to	to	PART
ctmj-148	196	19	determine	determine	VERB
ctmj-148	196	20	the	the	DET
ctmj-148	196	21	mechanisms	mechanism	NOUN
ctmj-148	196	22	involved	involve	VERB
ctmj-148	196	23	in	in	ADP
ctmj-148	196	24	the	the	DET
ctmj-148	196	25	laxative	laxative	ADJ
ctmj-148	196	26	effect	effect	NOUN
ctmj-148	196	27	of	of	ADP
ctmj-148	196	28	rhubarb	rhubarb	NOUN
ctmj-148	196	29	.	.	PUNCT
ctmj-148	197	1	we	we	PRON
ctmj-148	197	2	have	have	AUX
ctmj-148	197	3	shown	show	VERB
ctmj-148	197	4	that	that	SCONJ
ctmj-148	197	5	anthraquinone	anthraquinone	NOUN
ctmj-148	197	6	and	and	CCONJ
ctmj-148	197	7	anthrone	anthrone	NOUN
ctmj-148	197	8	derivatives	derivative	NOUN
ctmj-148	197	9	in	in	ADP
ctmj-148	197	10	rhubarb	rhubarb	NOUN
ctmj-148	197	11	can	can	AUX
ctmj-148	197	12	be	be	AUX
ctmj-148	197	13	metabolized	metabolize	VERB
ctmj-148	197	14	in	in	ADP
ctmj-148	197	15	the	the	DET
ctmj-148	197	16	rat	rat	NOUN
ctmj-148	197	17	intestine	intestine	NOUN
ctmj-148	197	18	to	to	PART
ctmj-148	197	19	generate	generate	VERB
ctmj-148	197	20	various	various	ADJ
ctmj-148	197	21	bioactive	bioactive	NOUN
ctmj-148	197	22	compounds	compound	NOUN
ctmj-148	197	23	,	,	PUNCT
ctmj-148	197	24	which	which	PRON
ctmj-148	197	25	are	be	AUX
ctmj-148	197	26	all	all	ADV
ctmj-148	197	27	capable	capable	ADJ
ctmj-148	197	28	of	of	ADP
ctmj-148	197	29	regulating	regulate	VERB
ctmj-148	197	30	molecular	molecular	ADJ
ctmj-148	197	31	targets	target	NOUN
ctmj-148	197	32	in	in	ADP
ctmj-148	197	33	the	the	DET
ctmj-148	197	34	colon	colon	NOUN
ctmj-148	197	35	that	that	PRON
ctmj-148	197	36	mediate	mediate	VERB
ctmj-148	197	37	the	the	DET
ctmj-148	197	38	laxative	laxative	NOUN
ctmj-148	197	39	effects	effect	NOUN
ctmj-148	197	40	of	of	ADP
ctmj-148	197	41	known	know	VERB
ctmj-148	197	42	drug	drug	NOUN
ctmj-148	197	43	substances	substance	NOUN
ctmj-148	197	44	(	(	PUNCT
ctmj-148	197	45	fig	fig	NOUN
ctmj-148	197	46	.	.	PUNCT
ctmj-148	197	47	9	9	NUM
ctmj-148	197	48	)	)	PUNCT
ctmj-148	197	49	.	.	PUNCT
ctmj-148	198	1	thus	thus	ADV
ctmj-148	198	2	,	,	PUNCT
ctmj-148	198	3	de	de	ADP
ctmj-148	198	4	rivatives	rivative	NOUN
ctmj-148	198	5	of	of	ADP
ctmj-148	198	6	rhubarb	rhubarb	NOUN
ctmj-148	198	7	may	may	AUX
ctmj-148	198	8	have	have	VERB
ctmj-148	198	9	additive	additive	ADJ
ctmj-148	198	10	or	or	CCONJ
ctmj-148	198	11	synergistic	synergistic	ADJ
ctmj-148	198	12	effects	effect	NOUN
ctmj-148	198	13	to	to	PART
ctmj-148	198	14	promote	promote	VERB
ctmj-148	198	15	defecation	defecation	NOUN
ctmj-148	198	16	.	.	PUNCT
ctmj-148	199	1	this	this	DET
ctmj-148	199	2	strategy	strategy	NOUN
ctmj-148	199	3	represents	represent	VERB
ctmj-148	199	4	a	a	DET
ctmj-148	199	5	valid	valid	ADJ
ctmj-148	199	6	approach	approach	NOUN
ctmj-148	199	7	to	to	PART
ctmj-148	199	8	ensure	ensure	VERB
ctmj-148	199	9	quality	quality	NOUN
ctmj-148	199	10	control	control	NOUN
ctmj-148	199	11	and	and	CCONJ
ctmj-148	199	12	to	to	PART
ctmj-148	199	13	provide	provide	VERB
ctmj-148	199	14	a	a	DET
ctmj-148	199	15	reference	reference	NOUN
ctmj-148	199	16	for	for	ADP
ctmj-148	199	17	the	the	DET
ctmj-148	199	18	rational	rational	ADJ
ctmj-148	199	19	medicinal	medicinal	ADJ
ctmj-148	199	20	use	use	NOUN
ctmj-148	199	21	of	of	ADP
ctmj-148	199	22	rhubarb	rhubarb	NOUN
ctmj-148	199	23	in	in	ADP
ctmj-148	199	24	the	the	DET
ctmj-148	199	25	clinic	clinic	NOUN
ctmj-148	199	26	.	.	PUNCT
ctmj-148	200	1	because	because	SCONJ
ctmj-148	200	2	of	of	ADP
ctmj-148	200	3	the	the	DET
ctmj-148	200	4	complexity	complexity	NOUN
ctmj-148	200	5	of	of	ADP
ctmj-148	200	6	potential	potential	ADJ
ctmj-148	200	7	medicinal	medicinal	ADJ
ctmj-148	200	8	compoundetarget	compoundetarget	NOUN
ctmj-148	200	9	interactions	interaction	NOUN
ctmj-148	200	10	,	,	PUNCT
ctmj-148	200	11	the	the	DET
ctmj-148	200	12	identification	identification	NOUN
ctmj-148	200	13	of	of	ADP
ctmj-148	200	14	interaction	interaction	NOUN
ctmj-148	200	15	domains	domain	NOUN
ctmj-148	200	16	is	be	AUX
ctmj-148	200	17	still	still	ADV
ctmj-148	200	18	in	in	ADP
ctmj-148	200	19	its	its	PRON
ctmj-148	200	20	infancy	infancy	NOUN
ctmj-148	200	21	.	.	PUNCT
ctmj-148	201	1	however	however	ADV
ctmj-148	201	2	,	,	PUNCT
ctmj-148	201	3	high	high	ADJ
ctmj-148	201	4	-	-	PUNCT
ctmj-148	201	5	affinity	affinity	NOUN
ctmj-148	201	6	ligandereceptor	ligandereceptor	NOUN
ctmj-148	201	7	interactions	interaction	NOUN
ctmj-148	201	8	can	can	AUX
ctmj-148	201	9	be	be	AUX
ctmj-148	201	10	validated	validate	VERB
ctmj-148	201	11	using	use	VERB
ctmj-148	201	12	surface	surface	NOUN
ctmj-148	201	13	plasmon	plasmon	ADJ
ctmj-148	201	14	resonance	resonance	NOUN
ctmj-148	201	15	studies,38,39	studies,38,39	NOUN
ctmj-148	201	16	and	and	CCONJ
ctmj-148	201	17	his	his	PRON
ctmj-148	201	18	method	method	NOUN
ctmj-148	201	19	may	may	AUX
ctmj-148	201	20	be	be	AUX
ctmj-148	201	21	used	use	VERB
ctmj-148	201	22	to	to	PART
ctmj-148	201	23	fig	fig	VERB
ctmj-148	201	24	.	.	PUNCT
ctmj-148	202	1	9	9	X
ctmj-148	202	2	.	.	X
ctmj-148	202	3	summary	summary	NOUN
ctmj-148	202	4	of	of	ADP
ctmj-148	202	5	the	the	DET
ctmj-148	202	6	study	study	NOUN
ctmj-148	202	7	findings	finding	NOUN
ctmj-148	202	8	.	.	PUNCT
ctmj-148	203	1	abbreviations	abbreviation	NOUN
ctmj-148	203	2	:	:	PUNCT
ctmj-148	203	3	5	5	NUM
ctmj-148	203	4	-	-	PUNCT
ctmj-148	203	5	ht4	ht4	NOUN
ctmj-148	203	6	:	:	PUNCT
ctmj-148	203	7	5	5	NUM
ctmj-148	203	8	-	-	PUNCT
ctmj-148	203	9	hydroxytryptamine	hydroxytryptamine	NOUN
ctmj-148	203	10	receptor	receptor	NOUN
ctmj-148	203	11	4	4	NUM
ctmj-148	203	12	;	;	PUNCT
ctmj-148	203	13	aqp3	aqp3	PROPN
ctmj-148	203	14	:	:	PUNCT
ctmj-148	203	15	aquaporin-3	aquaporin-3	PROPN
ctmj-148	203	16	.	.	PROPN
ctmj-148	203	17	ctmj	ctmj	PROPN
ctmj-148	204	1	|	|	ADV
ctmj-148	204	2	traditionalmedicinejournals.com	traditionalmedicinejournals.com	X
ctmj-148	204	3	issn	issn	PROPN
ctmj-148	204	4	:	:	PUNCT
ctmj-148	204	5	2693	2693	NUM
ctmj-148	204	6	6356	6356	NUM
ctmj-148	204	7	2024	2024	NUM
ctmj-148	204	8	|	|	ADV
ctmj-148	204	9	vol	vol	NOUN
ctmj-148	204	10	7	7	NUM
ctmj-148	204	11	|	|	NOUN
ctmj-148	204	12	issue	issue	VERB
ctmj-148	204	13	1	1	NUM
ctmj-148	204	14	further	far	ADV
ctmj-148	204	15	characterize	characterize	VERB
ctmj-148	204	16	the	the	DET
ctmj-148	204	17	molecular	molecular	ADJ
ctmj-148	204	18	mechanisms	mechanism	NOUN
ctmj-148	204	19	involved	involve	VERB
ctmj-148	204	20	in	in	ADP
ctmj-148	204	21	the	the	DET
ctmj-148	204	22	laxative	laxative	ADJ
ctmj-148	204	23	effect	effect	NOUN
ctmj-148	204	24	of	of	ADP
ctmj-148	204	25	rhubarb	rhubarb	NOUN
ctmj-148	204	26	and	and	CCONJ
ctmj-148	204	27	to	to	PART
ctmj-148	204	28	identify	identify	VERB
ctmj-148	204	29	lead	lead	VERB
ctmj-148	204	30	compounds	compound	NOUN
ctmj-148	204	31	for	for	ADP
ctmj-148	204	32	further	further	ADJ
ctmj-148	204	33	investigation	investigation	NOUN
ctmj-148	204	34	.	.	PUNCT
ctmj-148	205	1	most	most	ADV
ctmj-148	205	2	herbal	herbal	ADJ
ctmj-148	205	3	medicines	medicine	NOUN
ctmj-148	205	4	contain	contain	VERB
ctmj-148	205	5	numerous	numerous	ADJ
ctmj-148	205	6	components	component	NOUN
ctmj-148	205	7	that	that	PRON
ctmj-148	205	8	may	may	AUX
ctmj-148	205	9	be	be	AUX
ctmj-148	205	10	bioactive	bioactive	ADJ
ctmj-148	205	11	or	or	CCONJ
ctmj-148	205	12	metabolized	metabolize	VERB
ctmj-148	205	13	to	to	PART
ctmj-148	205	14	form	form	VERB
ctmj-148	205	15	bioactive	bioactive	ADJ
ctmj-148	205	16	derivatives	derivative	NOUN
ctmj-148	205	17	,	,	PUNCT
ctmj-148	205	18	such	such	ADJ
ctmj-148	205	19	as	as	ADP
ctmj-148	205	20	flavonoids	flavonoid	NOUN
ctmj-148	205	21	,	,	PUNCT
ctmj-148	205	22	alkaloids	alkaloid	NOUN
ctmj-148	205	23	,	,	PUNCT
ctmj-148	205	24	and	and	CCONJ
ctmj-148	205	25	organic	organic	ADJ
ctmj-148	205	26	acids	acid	NOUN
ctmj-148	205	27	.	.	PUNCT
ctmj-148	206	1	rhubarb	rhubarb	NOUN
ctmj-148	206	2	is	be	AUX
ctmj-148	206	3	a	a	DET
ctmj-148	206	4	common	common	ADJ
ctmj-148	206	5	chinese	chinese	ADJ
ctmj-148	206	6	medicine	medicine	NOUN
ctmj-148	206	7	that	that	PRON
ctmj-148	206	8	also	also	ADV
ctmj-148	206	9	contains	contain	VERB
ctmj-148	206	10	several	several	ADJ
ctmj-148	206	11	components	component	NOUN
ctmj-148	206	12	of	of	ADP
ctmj-148	206	13	this	this	DET
ctmj-148	206	14	type	type	NOUN
ctmj-148	206	15	,	,	PUNCT
ctmj-148	206	16	including	include	VERB
ctmj-148	206	17	anthraquinone	anthraquinone	NOUN
ctmj-148	206	18	derivatives	derivative	NOUN
ctmj-148	206	19	,	,	PUNCT
ctmj-148	206	20	anthrone	anthrone	NOUN
ctmj-148	206	21	derivatives	derivative	NOUN
ctmj-148	206	22	,	,	PUNCT
ctmj-148	206	23	glucosides	glucoside	NOUN
ctmj-148	206	24	,	,	PUNCT
ctmj-148	206	25	tannins	tannin	NOUN
ctmj-148	206	26	,	,	PUNCT
ctmj-148	206	27	and	and	CCONJ
ctmj-148	206	28	organic	organic	ADJ
ctmj-148	206	29	acids	acid	NOUN
ctmj-148	206	30	.	.	PUNCT
ctmj-148	207	1	in	in	ADP
ctmj-148	207	2	the	the	DET
ctmj-148	207	3	present	present	ADJ
ctmj-148	207	4	study	study	NOUN
ctmj-148	207	5	,	,	PUNCT
ctmj-148	207	6	rhubarb	rhubarb	NOUN
ctmj-148	207	7	was	be	AUX
ctmj-148	207	8	used	use	VERB
ctmj-148	207	9	as	as	ADP
ctmj-148	207	10	an	an	DET
ctmj-148	207	11	example	example	NOUN
ctmj-148	207	12	to	to	PART
ctmj-148	207	13	illustrate	illustrate	VERB
ctmj-148	207	14	an	an	DET
ctmj-148	207	15	approach	approach	NOUN
ctmj-148	207	16	to	to	ADP
ctmj-148	207	17	the	the	DET
ctmj-148	207	18	determination	determination	NOUN
ctmj-148	207	19	of	of	ADP
ctmj-148	207	20	the	the	DET
ctmj-148	207	21	mechanisms	mechanism	NOUN
ctmj-148	207	22	of	of	ADP
ctmj-148	207	23	a	a	DET
ctmj-148	207	24	medicinal	medicinal	ADJ
ctmj-148	207	25	effect	effect	NOUN
ctmj-148	207	26	of	of	ADP
ctmj-148	207	27	a	a	DET
ctmj-148	207	28	plant	plant	NOUN
ctmj-148	207	29	product	product	NOUN
ctmj-148	207	30	.	.	PUNCT
ctmj-148	208	1	in	in	ADP
ctmj-148	208	2	it	it	PRON
ctmj-148	208	3	,	,	PUNCT
ctmj-148	208	4	we	we	PRON
ctmj-148	208	5	identified	identify	VERB
ctmj-148	208	6	bioactive	bioactive	PROPN
ctmj-148	208	7	compounds	compound	NOUN
ctmj-148	208	8	,	,	PUNCT
ctmj-148	208	9	determined	determine	VERB
ctmj-148	208	10	their	their	PRON
ctmj-148	208	11	origin	origin	NOUN
ctmj-148	208	12	in	in	ADP
ctmj-148	208	13	the	the	DET
ctmj-148	208	14	plant	plant	NOUN
ctmj-148	208	15	,	,	PUNCT
ctmj-148	208	16	and	and	CCONJ
ctmj-148	208	17	identified	identify	VERB
ctmj-148	208	18	potential	potential	ADJ
ctmj-148	208	19	binding	bind	VERB
ctmj-148	208	20	partners	partner	NOUN
ctmj-148	208	21	that	that	PRON
ctmj-148	208	22	are	be	AUX
ctmj-148	208	23	known	know	VERB
ctmj-148	208	24	mediators	mediator	NOUN
ctmj-148	208	25	of	of	ADP
ctmj-148	208	26	the	the	DET
ctmj-148	208	27	medicinal	medicinal	ADJ
ctmj-148	208	28	effect	effect	NOUN
ctmj-148	208	29	.	.	PUNCT
ctmj-148	209	1	this	this	DET
ctmj-148	209	2	strategy	strategy	NOUN
ctmj-148	209	3	can	can	AUX
ctmj-148	209	4	provide	provide	VERB
ctmj-148	209	5	insights	insight	NOUN
ctmj-148	209	6	into	into	ADP
ctmj-148	209	7	the	the	DET
ctmj-148	209	8	mechanisms	mechanism	NOUN
ctmj-148	209	9	whereby	whereby	SCONJ
ctmj-148	209	10	multiple	multiple	ADJ
ctmj-148	209	11	components	component	NOUN
ctmj-148	209	12	of	of	ADP
ctmj-148	209	13	herbal	herbal	ADJ
ctmj-148	209	14	medicines	medicine	NOUN
ctmj-148	209	15	may	may	AUX
ctmj-148	209	16	have	have	VERB
ctmj-148	209	17	additive	additive	ADJ
ctmj-148	209	18	or	or	CCONJ
ctmj-148	209	19	synergistic	synergistic	ADJ
ctmj-148	209	20	effects	effect	NOUN
ctmj-148	209	21	,	,	PUNCT
ctmj-148	209	22	exerted	exert	VERB
ctmj-148	209	23	via	via	ADP
ctmj-148	209	24	multiple	multiple	ADJ
ctmj-148	209	25	molecular	molecular	ADJ
ctmj-148	209	26	targets	target	NOUN
ctmj-148	209	27	,	,	PUNCT
ctmj-148	209	28	to	to	PART
ctmj-148	209	29	achieve	achieve	VERB
ctmj-148	209	30	a	a	DET
ctmj-148	209	31	therapeutic	therapeutic	ADJ
ctmj-148	209	32	endpoint	endpoint	NOUN
ctmj-148	209	33	.	.	PUNCT
ctmj-148	210	1	conclusion	conclusion	NOUN
ctmj-148	210	2	by	by	ADP
ctmj-148	210	3	binding	bind	VERB
ctmj-148	210	4	to	to	ADP
ctmj-148	210	5	c	c	NOUN
ctmj-148	210	6	-	-	PUNCT
ctmj-148	210	7	kit	kit	NOUN
ctmj-148	210	8	,	,	PUNCT
ctmj-148	210	9	5	5	NUM
ctmj-148	210	10	-	-	PUNCT
ctmj-148	210	11	ht4	ht4	ADJ
ctmj-148	210	12	,	,	PUNCT
ctmj-148	210	13	and/or	and/or	CCONJ
ctmj-148	210	14	aqp3	aqp3	PROPN
ctmj-148	210	15	,	,	PUNCT
ctmj-148	210	16	the	the	DET
ctmj-148	210	17	current	current	ADJ
ctmj-148	210	18	research	research	NOUN
ctmj-148	210	19	showed	show	VERB
ctmj-148	210	20	that	that	SCONJ
ctmj-148	210	21	bioactive	bioactive	VERB
ctmj-148	210	22	chemicals	chemical	NOUN
ctmj-148	210	23	with	with	ADP
ctmj-148	210	24	a	a	DET
ctmj-148	210	25	laxative	laxative	ADJ
ctmj-148	210	26	action	action	NOUN
ctmj-148	210	27	might	might	AUX
ctmj-148	210	28	be	be	AUX
ctmj-148	210	29	generated	generate	VERB
ctmj-148	210	30	by	by	ADP
ctmj-148	210	31	metabolism	metabolism	NOUN
ctmj-148	210	32	of	of	ADP
ctmj-148	210	33	anthraquinones	anthraquinone	NOUN
ctmj-148	210	34	and	and	CCONJ
ctmj-148	210	35	anthrones	anthrone	NOUN
ctmj-148	210	36	in	in	ADP
ctmj-148	210	37	rhubarb	rhubarb	NOUN
ctmj-148	210	38	.	.	PUNCT
ctmj-148	211	1	it	it	PRON
ctmj-148	211	2	was	be	AUX
ctmj-148	211	3	indicated	indicate	VERB
ctmj-148	211	4	using	use	VERB
ctmj-148	211	5	molecular	molecular	ADJ
ctmj-148	211	6	docking	docking	NOUN
ctmj-148	211	7	modelling	model	VERB
ctmj-148	211	8	that	that	SCONJ
ctmj-148	211	9	five	five	NUM
ctmj-148	211	10	anthraquinones	anthraquinone	NOUN
ctmj-148	211	11	(	(	PUNCT
ctmj-148	211	12	aloe	aloe	PROPN
ctmj-148	211	13	-	-	PUNCT
ctmj-148	211	14	emodin	emodin	PROPN
ctmj-148	211	15	,	,	PUNCT
ctmj-148	211	16	emodin	emodin	PROPN
ctmj-148	211	17	,	,	PUNCT
ctmj-148	211	18	rhein	rhein	NOUN
ctmj-148	211	19	,	,	PUNCT
ctmj-148	211	20	chrysophanol	chrysophanol	NOUN
ctmj-148	211	21	,	,	PUNCT
ctmj-148	211	22	and	and	CCONJ
ctmj-148	211	23	physcion	physcion	NOUN
ctmj-148	211	24	)	)	PUNCT
ctmj-148	211	25	and	and	CCONJ
ctmj-148	211	26	five	five	NUM
ctmj-148	211	27	anthrones	anthrone	NOUN
ctmj-148	211	28	(	(	PUNCT
ctmj-148	211	29	sennoside	sennoside	VERB
ctmj-148	211	30	a	a	PRON
ctmj-148	211	31	,	,	PUNCT
ctmj-148	211	32	sennoside	sennoside	NOUN
ctmj-148	211	33	c	c	NOUN
ctmj-148	211	34	,	,	PUNCT
ctmj-148	211	35	physcionanthrone	physcionanthrone	NOUN
ctmj-148	211	36	,	,	PUNCT
ctmj-148	211	37	aloe	aloe	NOUN
ctmj-148	211	38	-	-	PUNCT
ctmj-148	211	39	emodinanthrone	emodinanthrone	NOUN
ctmj-148	211	40	,	,	PUNCT
ctmj-148	211	41	and	and	CCONJ
ctmj-148	211	42	rheinanthrone	rheinanthrone	NOUN
ctmj-148	211	43	)	)	PUNCT
ctmj-148	211	44	interact	interact	VERB
ctmj-148	211	45	with	with	ADP
ctmj-148	211	46	c	c	NOUN
ctmj-148	211	47	-	-	PUNCT
ctmj-148	211	48	kit	kit	NOUN
ctmj-148	211	49	,	,	PUNCT
ctmj-148	211	50	5	5	NUM
ctmj-148	211	51	-	-	PUNCT
ctmj-148	211	52	ht4	ht4	NOUN
ctmj-148	211	53	,	,	PUNCT
ctmj-148	211	54	and	and	CCONJ
ctmj-148	211	55	aqp3	aqp3	PROPN
ctmj-148	211	56	.	.	PUNCT
ctmj-148	212	1	importantly	importantly	ADV
ctmj-148	212	2	,	,	PUNCT
ctmj-148	212	3	we	we	PRON
ctmj-148	212	4	have	have	AUX
ctmj-148	212	5	shown	show	VERB
ctmj-148	212	6	that	that	SCONJ
ctmj-148	212	7	rhubarb	rhubarb	NOUN
ctmj-148	212	8	extract	extract	NOUN
ctmj-148	212	9	,	,	PUNCT
ctmj-148	212	10	which	which	PRON
ctmj-148	212	11	is	be	AUX
ctmj-148	212	12	believed	believe	VERB
ctmj-148	212	13	to	to	PART
ctmj-148	212	14	mediate	mediate	VERB
ctmj-148	212	15	the	the	DET
ctmj-148	212	16	laxative	laxative	ADJ
ctmj-148	212	17	action	action	NOUN
ctmj-148	212	18	of	of	ADP
ctmj-148	212	19	the	the	DET
ctmj-148	212	20	plant	plant	NOUN
ctmj-148	212	21	,	,	PUNCT
ctmj-148	212	22	raised	raise	VERB
ctmj-148	212	23	the	the	DET
ctmj-148	212	24	expression	expression	NOUN
ctmj-148	212	25	of	of	ADP
ctmj-148	212	26	c	c	NOUN
ctmj-148	212	27	-	-	PUNCT
ctmj-148	212	28	kit	kit	NOUN
ctmj-148	212	29	and	and	CCONJ
ctmj-148	212	30	5	5	NUM
ctmj-148	212	31	-	-	PUNCT
ctmj-148	212	32	ht4	ht4	NOUN
ctmj-148	212	33	,	,	PUNCT
ctmj-148	212	34	while	while	SCONJ
ctmj-148	212	35	reducing	reduce	VERB
ctmj-148	212	36	that	that	PRON
ctmj-148	212	37	of	of	ADP
ctmj-148	212	38	aqp3	aqp3	PROPN
ctmj-148	212	39	in	in	ADP
ctmj-148	212	40	the	the	DET
ctmj-148	212	41	rat	rat	NOUN
ctmj-148	212	42	colon	colon	NOUN
ctmj-148	212	43	.	.	PUNCT
ctmj-148	213	1	additionally	additionally	ADV
ctmj-148	213	2	,	,	PUNCT
ctmj-148	213	3	we	we	PRON
ctmj-148	213	4	discovered	discover	VERB
ctmj-148	213	5	that	that	SCONJ
ctmj-148	213	6	a	a	DET
ctmj-148	213	7	single	single	ADJ
ctmj-148	213	8	proto	proto	NOUN
ctmj-148	213	9	-	-	PUNCT
ctmj-148	213	10	type	type	NOUN
ctmj-148	213	11	component	component	NOUN
ctmj-148	213	12	in	in	ADP
ctmj-148	213	13	rhubarb	rhubarb	NOUN
ctmj-148	213	14	,	,	PUNCT
ctmj-148	213	15	like	like	ADP
ctmj-148	213	16	sennoside	sennoside	NOUN
ctmj-148	213	17	a	a	PRON
ctmj-148	213	18	,	,	PUNCT
ctmj-148	213	19	can	can	AUX
ctmj-148	213	20	be	be	AUX
ctmj-148	213	21	metabolised	metabolise	VERB
ctmj-148	213	22	into	into	ADP
ctmj-148	213	23	multiple	multiple	ADJ
ctmj-148	213	24	active	active	ADJ
ctmj-148	213	25	metabolites	metabolite	NOUN
ctmj-148	213	26	(	(	PUNCT
ctmj-148	213	27	rheinanthrone	rheinanthrone	NOUN
ctmj-148	213	28	,	,	PUNCT
ctmj-148	213	29	emodin	emodin	PROPN
ctmj-148	213	30	,	,	PUNCT
ctmj-148	213	31	chrysophanol	chrysophanol	NOUN
ctmj-148	213	32	,	,	PUNCT
ctmj-148	213	33	aloeemodin	aloeemodin	NOUN
ctmj-148	213	34	,	,	PUNCT
ctmj-148	213	35	rhein	rhein	NOUN
ctmj-148	213	36	,	,	PUNCT
ctmj-148	213	37	and	and	CCONJ
ctmj-148	213	38	physcion	physcion	NOUN
ctmj-148	213	39	)	)	PUNCT
ctmj-148	213	40	,	,	PUNCT
ctmj-148	213	41	as	as	ADV
ctmj-148	213	42	well	well	ADV
ctmj-148	213	43	as	as	ADP
ctmj-148	213	44	one	one	NUM
ctmj-148	213	45	active	active	ADJ
ctmj-148	213	46	ingredient	ingredient	NOUN
ctmj-148	213	47	,	,	PUNCT
ctmj-148	213	48	compounds	compound	NOUN
ctmj-148	213	49	including	include	VERB
ctmj-148	213	50	physcion	physcion	NOUN
ctmj-148	213	51	,	,	PUNCT
ctmj-148	213	52	emodin	emodin	PROPN
ctmj-148	213	53	,	,	PUNCT
ctmj-148	213	54	chrysophanol	chrysophanol	NOUN
ctmj-148	213	55	,	,	PUNCT
ctmj-148	213	56	aloe	aloe	PROPN
ctmj-148	213	57	-	-	PUNCT
ctmj-148	213	58	emodin	emodin	PROPN
ctmj-148	213	59	,	,	PUNCT
ctmj-148	213	60	sennoside	sennoside	NOUN
ctmj-148	213	61	c	c	NOUN
ctmj-148	213	62	,	,	PUNCT
ctmj-148	213	63	and	and	CCONJ
ctmj-148	213	64	sennoside	sennoside	VERB
ctmj-148	213	65	a	a	PRON
ctmj-148	213	66	are	be	AUX
ctmj-148	213	67	potentially	potentially	ADV
ctmj-148	213	68	potential	potential	ADJ
ctmj-148	213	69	building	building	NOUN
ctmj-148	213	70	blocks	block	NOUN
ctmj-148	213	71	for	for	ADP
ctmj-148	213	72	compounds	compound	NOUN
ctmj-148	213	73	like	like	ADP
ctmj-148	213	74	rhein	rhein	NOUN
ctmj-148	213	75	.	.	PUNCT
ctmj-148	214	1	our	our	PRON
ctmj-148	214	2	results	result	NOUN
ctmj-148	214	3	suggest	suggest	VERB
ctmj-148	214	4	that	that	SCONJ
ctmj-148	214	5	rhubarb	rhubarb	NOUN
ctmj-148	214	6	's	's	PART
ctmj-148	214	7	laxative	laxative	ADJ
ctmj-148	214	8	action	action	NOUN
ctmj-148	214	9	could	could	AUX
ctmj-148	214	10	be	be	AUX
ctmj-148	214	11	due	due	ADJ
ctmj-148	214	12	to	to	ADP
ctmj-148	214	13	the	the	DET
ctmj-148	214	14	interaction	interaction	NOUN
ctmj-148	214	15	of	of	ADP
ctmj-148	214	16	several	several	ADJ
ctmj-148	214	17	derivative	derivative	ADJ
ctmj-148	214	18	chemicals	chemical	NOUN
ctmj-148	214	19	with	with	ADP
ctmj-148	214	20	various	various	ADJ
ctmj-148	214	21	molecular	molecular	ADJ
ctmj-148	214	22	targets	target	NOUN
ctmj-148	214	23	in	in	ADP
ctmj-148	214	24	the	the	DET
ctmj-148	214	25	colon	colon	NOUN
ctmj-148	214	26	,	,	PUNCT
ctmj-148	214	27	which	which	PRON
ctmj-148	214	28	might	might	AUX
ctmj-148	214	29	lead	lead	VERB
ctmj-148	214	30	to	to	PART
ctmj-148	214	31	cumulative	cumulative	ADJ
ctmj-148	214	32	or	or	CCONJ
ctmj-148	214	33	synergistic	synergistic	ADJ
ctmj-148	214	34	effects	effect	NOUN
ctmj-148	214	35	.	.	PUNCT
ctmj-148	215	1	references	reference	NOUN
ctmj-148	215	2	1	1	NUM
ctmj-148	215	3	.	.	NOUN
ctmj-148	215	4	1	1	NUM
ctmj-148	215	5	.	.	PUNCT
ctmj-148	216	1	huang	huang	PROPN
ctmj-148	216	2	q	q	PROPN
ctmj-148	216	3	,	,	PUNCT
ctmj-148	216	4	lu	lu	PROPN
ctmj-148	216	5	gd	gd	NOUN
ctmj-148	216	6	,	,	PUNCT
ctmj-148	216	7	shen	shen	PROPN
ctmj-148	216	8	hm	hm	PROPN
ctmj-148	216	9	,	,	PUNCT
ctmj-148	216	10	chung	chung	PROPN
ctmj-148	216	11	mc	mc	PROPN
ctmj-148	216	12	,	,	PUNCT
ctmj-148	216	13	ong	ong	PROPN
ctmj-148	216	14	cn	cn	PROPN
ctmj-148	216	15	.	.	PUNCT
ctmj-148	216	16	rhaquinones	rhaquinone	NOUN
ctmj-148	216	17	from	from	ADP
ctmj-148	216	18	rhubarb	rhubarb	NOUN
ctmj-148	216	19	and	and	CCONJ
ctmj-148	216	20	their	their	PRON
ctmj-148	216	21	anti	anti	ADJ
ctmj-148	216	22	-	-	ADJ
ctmj-148	216	23	cancer	cancer	ADJ
ctmj-148	216	24	effects	effect	NOUN
ctmj-148	216	25	.	.	PUNCT
ctmj-148	217	1	medical	medical	ADJ
ctmj-148	217	2	research	research	PROPN
ctmj-148	217	3	review	review	NOUN
ctmj-148	217	4	.	.	PUNCT
ctmj-148	218	1	2007;27(5):609–630	2007;27(5):609–630	NUM
ctmj-148	218	2	.	.	PUNCT
ctmj-148	218	3	presented	present	VERB
ctmj-148	218	4	by	by	ADP
ctmj-148	218	5	matsuda	matsuda	PROPN
ctmj-148	218	6	,	,	PUNCT
ctmj-148	218	7	morikawa	morikawa	PROPN
ctmj-148	218	8	,	,	PUNCT
ctmj-148	218	9	toguchida	toguchida	PROPN
ctmj-148	218	10	,	,	PUNCT
ctmj-148	218	11	park	park	NOUN
ctmj-148	218	12	,	,	PUNCT
ctmj-148	218	13	yoshikawa	yoshikawa	PROPN
ctmj-148	218	14	,	,	PUNCT
ctmj-148	218	15	and	and	CCONJ
ctmj-148	218	16	harima	harima	PROPN
ctmj-148	218	17	.	.	PUNCT
ctmj-148	219	1	new	new	ADJ
ctmj-148	219	2	anthraquinone	anthraquinone	NOUN
ctmj-148	219	3	glucoside	glucoside	NOUN
ctmj-148	219	4	compounds	compound	NOUN
ctmj-148	219	5	and	and	CCONJ
ctmj-148	219	6	structural	structural	ADJ
ctmj-148	219	7	criteria	criterion	NOUN
ctmj-148	219	8	for	for	ADP
ctmj-148	219	9	stilbene	stilbene	NOUN
ctmj-148	219	10	activity	activity	NOUN
ctmj-148	219	11	:	:	PUNCT
ctmj-148	219	12	anti	anti	ADJ
ctmj-148	219	13	-	-	ADJ
ctmj-148	219	14	oxidant	oxidant	ADJ
ctmj-148	219	15	components	component	NOUN
ctmj-148	219	16	derived	derive	VERB
ctmj-148	219	17	from	from	ADP
ctmj-148	219	18	rhubarb	rhubarb	NOUN
ctmj-148	219	19	.	.	PUNCT
ctmj-148	220	1	the	the	DET
ctmj-148	220	2	published	publish	VERB
ctmj-148	220	3	article	article	NOUN
ctmj-148	220	4	is	be	AUX
ctmj-148	220	5	from	from	ADP
ctmj-148	220	6	2001	2001	NUM
ctmj-148	220	7	and	and	CCONJ
ctmj-148	220	8	is	be	AUX
ctmj-148	220	9	titled	title	VERB
ctmj-148	220	10	"	"	PUNCT
ctmj-148	220	11	bioorg	bioorg	ADJ
ctmj-148	220	12	med	med	ADJ
ctmj-148	220	13	chem	chem	NOUN
ctmj-148	220	14	.	.	PUNCT
ctmj-148	220	15	"	"	PUNCT
ctmj-148	221	1	it	it	PRON
ctmj-148	221	2	covers	cover	VERB
ctmj-148	221	3	pages	page	NOUN
ctmj-148	221	4	41–50	41–50	NOUN
ctmj-148	221	5	.	.	PUNCT
ctmj-148	222	1	3	3	X
ctmj-148	222	2	.	.	X
ctmj-148	222	3	leng	leng	NOUN
ctmj-148	222	4	-	-	PUNCT
ctmj-148	222	5	peschlow	peschlow	PROPN
ctmj-148	222	6	e.	e.	PROPN
ctmj-148	222	7	sennosides	sennosides	PROPN
ctmj-148	222	8	and	and	CCONJ
ctmj-148	222	9	similar	similar	ADJ
ctmj-148	222	10	substances	substance	NOUN
ctmj-148	222	11	induce	induce	VERB
ctmj-148	222	12	rats	rat	NOUN
ctmj-148	222	13	to	to	PART
ctmj-148	222	14	have	have	VERB
ctmj-148	222	15	a	a	DET
ctmj-148	222	16	larger	large	ADJ
ctmj-148	222	17	intestinal	intestinal	ADJ
ctmj-148	222	18	transit	transit	NOUN
ctmj-148	222	19	time	time	NOUN
ctmj-148	222	20	that	that	PRON
ctmj-148	222	21	is	be	AUX
ctmj-148	222	22	accelerated	accelerate	VERB
ctmj-148	222	23	.	.	PUNCT
ctmj-148	223	1	the	the	DET
ctmj-148	223	2	article	article	NOUN
ctmj-148	223	3	was	be	AUX
ctmj-148	223	4	published	publish	VERB
ctmj-148	223	5	in	in	ADP
ctmj-148	223	6	the	the	DET
ctmj-148	223	7	journal	journal	NOUN
ctmj-148	223	8	of	of	ADP
ctmj-148	223	9	pharmaceutical	pharmaceutical	NOUN
ctmj-148	223	10	pharmacy	pharmacy	NOUN
ctmj-148	223	11	in	in	ADP
ctmj-148	223	12	1986	1986	NUM
ctmj-148	223	13	and	and	CCONJ
ctmj-148	223	14	ran	run	VERB
ctmj-148	223	15	from	from	ADP
ctmj-148	223	16	page	page	NOUN
ctmj-148	223	17	369	369	NUM
ctmj-148	223	18	to	to	ADP
ctmj-148	223	19	373	373	NUM
ctmj-148	223	20	.	.	PUNCT
ctmj-148	224	1	the	the	DET
ctmj-148	224	2	effects	effect	NOUN
ctmj-148	224	3	of	of	ADP
ctmj-148	224	4	sennosides	sennoside	NOUN
ctmj-148	224	5	on	on	ADP
ctmj-148	224	6	canine	canine	ADJ
ctmj-148	224	7	colonic	colonic	ADJ
ctmj-148	224	8	motility	motility	NOUN
ctmj-148	224	9	:	:	PUNCT
ctmj-148	224	10	proof	proof	NOUN
ctmj-148	224	11	of	of	ADP
ctmj-148	224	12	a	a	DET
ctmj-148	224	13	prostaglandin	prostaglandin	NOUN
ctmj-148	224	14	mediator	mediator	NOUN
ctmj-148	224	15	(	(	PUNCT
ctmj-148	224	16	staumont	staumont	NOUN
ctmj-148	224	17	g	g	PROPN
ctmj-148	224	18	,	,	PUNCT
ctmj-148	224	19	fioramonti	fioramonti	PROPN
ctmj-148	224	20	j	j	PROPN
ctmj-148	224	21	,	,	PUNCT
ctmj-148	224	22	frexinos	frexinos	PROPN
ctmj-148	224	23	j	j	PROPN
ctmj-148	224	24	,	,	PUNCT
ctmj-148	224	25	bueno	bueno	PROPN
ctmj-148	224	26	l.	l.	PROPN
ctmj-148	224	27	,	,	PUNCT
ctmj-148	224	28	2004	2004	NUM
ctmj-148	224	29	)	)	PUNCT
ctmj-148	224	30	.	.	PUNCT
ctmj-148	225	1	endocrinology	endocrinology	NOUN
ctmj-148	225	2	.	.	PUNCT
ctmj-148	226	1	1988;29(9):1180e1187	1988;29(9):1180e1187	NUM
ctmj-148	226	2	.	.	PUNCT
ctmj-148	227	1	sakai	sakai	PROPN
ctmj-148	227	2	,	,	PUNCT
ctmj-148	227	3	yamauchi	yamauchi	PROPN
ctmj-148	227	4	,	,	PUNCT
ctmj-148	227	5	and	and	CCONJ
ctmj-148	227	6	kuwano	kuwano	PROPN
ctmj-148	227	7	(	(	PUNCT
ctmj-148	227	8	2019	2019	NUM
ctmj-148	227	9	)	)	PUNCT
ctmj-148	227	10	.	.	PUNCT
ctmj-148	228	1	5	5	X
ctmj-148	228	2	.	.	X
ctmj-148	228	3	activation	activation	NOUN
ctmj-148	228	4	of	of	ADP
ctmj-148	228	5	sennoside	sennoside	NOUN
ctmj-148	228	6	a	a	DET
ctmj-148	228	7	metabolism	metabolism	NOUN
ctmj-148	228	8	in	in	ADP
ctmj-148	228	9	mice	mouse	NOUN
ctmj-148	228	10	.	.	PUNCT
ctmj-148	229	1	botanical	botanical	ADJ
ctmj-148	229	2	medicine	medicine	NOUN
ctmj-148	229	3	,	,	PUNCT
ctmj-148	229	4	1979	1979	NUM
ctmj-148	229	5	,	,	PUNCT
ctmj-148	229	6	37(4	37(4	PROPN
ctmj-148	229	7	):	):	PUNCT
ctmj-148	229	8	370–378	370–378	NUM
ctmj-148	229	9	.	.	NOUN
ctmj-148	230	1	6	6	NUM
ctmj-148	230	2	.	.	X
ctmj-148	230	3	vand	vand	PROPN
ctmj-148	230	4	hoestenberghe	hoestenberghe	PROPN
ctmj-148	230	5	a	a	PROPN
ctmj-148	230	6	,	,	PUNCT
ctmj-148	230	7	geboes	geboes	PROPN
ctmj-148	230	8	k	k	NOUN
ctmj-148	230	9	,	,	PUNCT
ctmj-148	230	10	nijs	nijs	ADV
ctmj-148	230	11	g	g	NOUN
ctmj-148	230	12	,	,	PUNCT
ctmj-148	230	13	lemli	lemli	PROPN
ctmj-148	230	14	j	j	PROPN
ctmj-148	230	15	,	,	PUNCT
ctmj-148	230	16	eyssen	eyssen	PROPN
ctmj-148	230	17	h	h	NOUN
ctmj-148	230	18	,	,	PUNCT
ctmj-148	230	19	de	de	PROPN
ctmj-148	230	20	witte	witte	PROPN
ctmj-148	230	21	p.	p.	NOUN
ctmj-148	230	22	in	in	ADP
ctmj-148	230	23	germfree	germfree	ADJ
ctmj-148	230	24	rats	rat	NOUN
ctmj-148	230	25	,	,	PUNCT
ctmj-148	230	26	the	the	DET
ctmj-148	230	27	effects	effect	NOUN
ctmj-148	230	28	of	of	ADP
ctmj-148	230	29	rhein	rhein	NOUN
ctmj-148	230	30	and	and	CCONJ
ctmj-148	230	31	rhein	rhein	NOUN
ctmj-148	230	32	anthrone	anthrone	NOUN
ctmj-148	230	33	on	on	ADP
ctmj-148	230	34	the	the	DET
ctmj-148	230	35	transfer	transfer	NOUN
ctmj-148	230	36	of	of	ADP
ctmj-148	230	37	intestinal	intestinal	ADJ
ctmj-148	230	38	fluid	fluid	NOUN
ctmj-148	230	39	and	and	CCONJ
ctmj-148	230	40	large	large	ADJ
ctmj-148	230	41	intestine	intestine	NOUN
ctmj-148	230	42	transit	transit	NOUN
ctmj-148	230	43	.	.	PUNCT
ctmj-148	231	1	article	article	NOUN
ctmj-148	231	2	published	publish	VERB
ctmj-148	231	3	in	in	ADP
ctmj-148	231	4	1992	1992	NUM
ctmj-148	231	5	in	in	ADP
ctmj-148	231	6	the	the	DET
ctmj-148	231	7	european	european	PROPN
ctmj-148	231	8	journal	journal	PROPN
ctmj-148	231	9	of	of	ADP
ctmj-148	231	10	pharmacology	pharmacology	NOUN
ctmj-148	231	11	,	,	PUNCT
ctmj-148	231	12	volume	volume	NOUN
ctmj-148	231	13	212	212	NUM
ctmj-148	231	14	,	,	PUNCT
ctmj-148	231	15	pages	page	NOUN
ctmj-148	231	16	121	121	NUM
ctmj-148	231	17	–	–	PUNCT
ctmj-148	231	18	123	123	NUM
ctmj-148	231	19	.	.	PUNCT
ctmj-148	232	1	the	the	DET
ctmj-148	232	2	authors	author	NOUN
ctmj-148	232	3	of	of	ADP
ctmj-148	232	4	this	this	DET
ctmj-148	232	5	work	work	NOUN
ctmj-148	232	6	are	be	AUX
ctmj-148	232	7	liu	liu	PROPN
ctmj-148	232	8	yh	yh	PROPN
ctmj-148	232	9	,	,	PUNCT
ctmj-148	232	10	huang	huang	PROPN
ctmj-148	232	11	zh	zh	PROPN
ctmj-148	232	12	,	,	PUNCT
ctmj-148	232	13	dong	dong	PROPN
ctmj-148	232	14	l	l	PROPN
ctmj-148	232	15	,	,	PUNCT
ctmj-148	232	16	pei	pei	PROPN
ctmj-148	232	17	wx	wx	PROPN
ctmj-148	232	18	,	,	PUNCT
ctmj-148	232	19	sun	sun	PROPN
ctmj-148	232	20	y	y	PROPN
ctmj-148	232	21	,	,	PUNCT
ctmj-148	232	22	and	and	CCONJ
ctmj-148	232	23	gao	gao	PROPN
ctmj-148	232	24	xy	xy	PROPN
ctmj-148	232	25	.	.	PUNCT
ctmj-148	233	1	rhei	rhei	PROPN
ctmj-148	233	2	radix	radix	PROPN
ctmj-148	233	3	et	et	PROPN
ctmj-148	233	4	rhizoma	rhizoma	PROPN
ctmj-148	233	5	's	's	PART
ctmj-148	233	6	14	14	NUM
ctmj-148	233	7	constituents	constituent	NOUN
ctmj-148	233	8	were	be	AUX
ctmj-148	233	9	all	all	PRON
ctmj-148	233	10	measured	measure	VERB
ctmj-148	233	11	simultaneously	simultaneously	ADV
ctmj-148	233	12	using	use	VERB
ctmj-148	233	13	a	a	DET
ctmj-148	233	14	high	high	ADJ
ctmj-148	233	15	-	-	PUNCT
ctmj-148	233	16	performance	performance	NOUN
ctmj-148	233	17	liquid	liquid	ADJ
ctmj-148	233	18	chromatography	chromatography	NOUN
ctmj-148	233	19	system	system	NOUN
ctmj-148	233	20	.	.	PUNCT
ctmj-148	234	1	[	[	X
ctmj-148	234	2	chinese	chinese	X
ctmj-148	234	3	]	]	PUNCT
ctmj-148	234	4	zhongguo	zhongguo	PROPN
ctmj-148	234	5	zhongyao	zhongyao	NOUN
ctmj-148	234	6	zazhi	zazhi	PROPN
ctmj-148	234	7	.	.	PUNCT
ctmj-148	235	1	2017;42(23	2017;42(23	NOUN
ctmj-148	235	2	):	):	PUNCT
ctmj-148	235	3	4514e4519	4514e4519	NUM
ctmj-148	235	4	.	.	PUNCT
ctmj-148	235	5	ito	ito	PROPN
ctmj-148	235	6	k	k	PROPN
ctmj-148	235	7	,	,	PUNCT
ctmj-148	235	8	yamasaki	yamasaki	PROPN
ctmj-148	235	9	k	k	PROPN
ctmj-148	235	10	,	,	PUNCT
ctmj-148	235	11	tagami	tagami	PROPN
ctmj-148	235	12	t	t	PROPN
ctmj-148	235	13	,	,	PUNCT
ctmj-148	235	14	sawabe	sawabe	ADJ
ctmj-148	235	15	y	y	PROPN
ctmj-148	235	16	,	,	PUNCT
ctmj-148	235	17	takatori	takatori	PROPN
ctmj-148	235	18	s.	s.	PROPN
ctmj-148	235	19	eight	eight	NUM
ctmj-148	235	20	.	.	PUNCT
ctmj-148	236	1	quick	quick	ADJ
ctmj-148	236	2	and	and	CCONJ
ctmj-148	236	3	easy	easy	ADJ
ctmj-148	236	4	determination	determination	NOUN
ctmj-148	236	5	of	of	ADP
ctmj-148	236	6	sennoside	sennoside	NOUN
ctmj-148	236	7	a	a	PRON
ctmj-148	236	8	and	and	CCONJ
ctmj-148	236	9	sennoside	sennoside	NOUN
ctmj-148	236	10	b	b	PROPN
ctmj-148	236	11	in	in	ADP
ctmj-148	236	12	unprocessed	unprocesse	VERB
ctmj-148	236	13	pharmaceuticals	pharmaceutical	NOUN
ctmj-148	236	14	and	and	CCONJ
ctmj-148	236	15	pharmaceutical	pharmaceutical	NOUN
ctmj-148	236	16	byproducts	byproduct	NOUN
ctmj-148	236	17	using	use	VERB
ctmj-148	236	18	solidphase	solidphase	NOUN
ctmj-148	236	19	extraction	extraction	NOUN
ctmj-148	236	20	and	and	CCONJ
ctmj-148	236	21	hplc	hplc	NOUN
ctmj-148	236	22	.	.	PUNCT
ctmj-148	237	1	proceedings	proceeding	NOUN
ctmj-148	237	2	of	of	ADP
ctmj-148	237	3	the	the	DET
ctmj-148	237	4	national	national	PROPN
ctmj-148	237	5	academy	academy	PROPN
ctmj-148	237	6	of	of	ADP
ctmj-148	237	7	sciences	sciences	PROPN
ctmj-148	237	8	.	.	PUNCT
ctmj-148	238	1	2010;64(2):126–132	2010;64(2):126–132	X
ctmj-148	238	2	.	.	PUNCT
ctmj-148	239	1	this	this	PRON
ctmj-148	239	2	is	be	AUX
ctmj-148	239	3	the	the	DET
ctmj-148	239	4	ninth	ninth	ADJ
ctmj-148	239	5	work	work	NOUN
ctmj-148	239	6	by	by	ADP
ctmj-148	239	7	ma	ma	PROPN
ctmj-148	239	8	,	,	PUNCT
ctmj-148	239	9	qi	qi	PROPN
ctmj-148	239	10	,	,	PUNCT
ctmj-148	239	11	xu	xu	PROPN
ctmj-148	239	12	,	,	PUNCT
ctmj-148	239	13	dong	dong	PROPN
ctmj-148	239	14	,	,	PUNCT
ctmj-148	239	15	and	and	CCONJ
ctmj-148	239	16	yang	yang	PROPN
ctmj-148	239	17	.	.	PUNCT
ctmj-148	240	1	how	how	SCONJ
ctmj-148	240	2	emodin	emodin	NOUN
ctmj-148	240	3	causes	cause	VERB
ctmj-148	240	4	smooth	smooth	ADJ
ctmj-148	240	5	muscle	muscle	NOUN
ctmj-148	240	6	cells	cell	NOUN
ctmj-148	240	7	in	in	ADP
ctmj-148	240	8	the	the	DET
ctmj-148	240	9	colon	colon	NOUN
ctmj-148	240	10	to	to	AUX
ctmj-148	240	11	contract	contract	NOUN
ctmj-148	240	12	:	:	PUNCT
ctmj-148	240	13	the	the	DET
ctmj-148	240	14	signal	signal	ADJ
ctmj-148	240	15	channels	channel	NOUN
ctmj-148	240	16	involved	involve	VERB
ctmj-148	240	17	.	.	PUNCT
ctmj-148	241	1	journal	journal	NOUN
ctmj-148	241	2	of	of	ADP
ctmj-148	241	3	the	the	DET
ctmj-148	241	4	world	world	NOUN
ctmj-148	241	5	gastrointestinal	gastrointestinal	NOUN
ctmj-148	241	6	and	and	CCONJ
ctmj-148	241	7	hepatology	hepatology	NOUN
ctmj-148	241	8	,	,	PUNCT
ctmj-148	241	9	2004;10(10):1476–1479	2004;10(10):1476–1479	NUM
ctmj-148	241	10	.	.	PUNCT
ctmj-148	242	1	10	10	NUM
ctmj-148	242	2	.	.	PUNCT
ctmj-148	243	1	huang	huang	PROPN
ctmj-148	243	2	yh	yh	PROPN
ctmj-148	243	3	,	,	PUNCT
ctmj-148	243	4	liu	liu	PROPN
ctmj-148	243	5	mt	mt	PROPN
ctmj-148	243	6	,	,	PUNCT
ctmj-148	243	7	gershon	gershon	PROPN
ctmj-148	243	8	md	md	PROPN
ctmj-148	243	9	,	,	PUNCT
ctmj-148	243	10	wang	wang	PROPN
ctmj-148	243	11	jw	jw	PROPN
ctmj-148	243	12	,	,	PUNCT
ctmj-148	243	13	hen	hen	PROPN
ctmj-148	243	14	r.	r.	PROPN
ctmj-148	243	15	the	the	DET
ctmj-148	243	16	enteric	enteric	ADJ
ctmj-148	243	17	nervous	nervous	ADJ
ctmj-148	243	18	system	system	NOUN
ctmj-148	243	19	of	of	ADP
ctmj-148	243	20	adult	adult	NOUN
ctmj-148	243	21	mice	mouse	NOUN
ctmj-148	243	22	:	:	PUNCT
ctmj-148	243	23	5	5	NUM
ctmj-148	243	24	-	-	PUNCT
ctmj-148	243	25	ht4	ht4	NOUN
ctmj-148	243	26	receptormediated	receptormediate	VERB
ctmj-148	243	27	neuroprotection	neuroprotection	NOUN
ctmj-148	243	28	and	and	CCONJ
ctmj-148	243	29	neurogenesis	neurogenesis	NOUN
ctmj-148	243	30	.	.	PUNCT
ctmj-148	244	1	journal	journal	NOUN
ctmj-148	244	2	of	of	ADP
ctmj-148	244	3	neuroscience	neuroscience	NOUN
ctmj-148	244	4	.	.	PUNCT
ctmj-148	245	1	2009;29(31):9683–9699	2009;29(31):9683–9699	NOUN
ctmj-148	245	2	.	.	PUNCT
ctmj-148	246	1	north	north	PROPN
ctmj-148	246	2	ra	ra	PROPN
ctmj-148	246	3	,	,	PUNCT
ctmj-148	246	4	galligan	galligan	VERB
ctmj-148	246	5	jj	jj	PROPN
ctmj-148	246	6	,	,	PUNCT
ctmj-148	246	7	and	and	CCONJ
ctmj-148	246	8	tonini	tonini	PROPN
ctmj-148	246	9	m.	m.	NOUN
ctmj-148	246	10	11	11	NUM
ctmj-148	246	11	.	.	PUNCT
ctmj-148	247	1	circulatory	circulatory	ADJ
ctmj-148	247	2	cholinergic	cholinergic	ADJ
ctmj-148	247	3	transmission	transmission	NOUN
ctmj-148	247	4	and	and	CCONJ
ctmj-148	247	5	propeller	propeller	NOUN
ctmj-148	247	6	-	-	PUNCT
ctmj-148	247	7	induced	induce	VERB
ctmj-148	247	8	ileal	ileal	ADJ
ctmj-148	247	9	motility	motility	NOUN
ctmj-148	247	10	in	in	ADP
ctmj-148	247	11	guinea	guinea	NOUN
ctmj-148	247	12	pigs	pig	NOUN
ctmj-148	247	13	as	as	ADP
ctmj-148	247	14	a	a	DET
ctmj-148	247	15	result	result	NOUN
ctmj-148	247	16	of	of	ADP
ctmj-148	247	17	cisapride	cisapride	NOUN
ctmj-148	247	18	.	.	PUNCT
ctmj-148	248	1	"	"	PUNCT
ctmj-148	248	2	gastroenterology	gastroenterology	NOUN
ctmj-148	248	3	"	"	PUNCT
ctmj-148	248	4	(	(	PUNCT
ctmj-148	248	5	volume	volume	NOUN
ctmj-148	248	6	96	96	NUM
ctmj-148	248	7	,	,	PUNCT
ctmj-148	248	8	issue	issue	NOUN
ctmj-148	248	9	1	1	NUM
ctmj-148	248	10	,	,	PUNCT
ctmj-148	248	11	1989	1989	NUM
ctmj-148	248	12	):	):	PUNCT
ctmj-148	248	13	1257–1264	1257–1264	NUM
ctmj-148	248	14	.	.	PUNCT
ctmj-148	249	1	section	section	NOUN
ctmj-148	249	2	12	12	NUM
ctmj-148	249	3	:	:	PUNCT
ctmj-148	249	4	ikarashi	ikarashi	PROPN
ctmj-148	249	5	,	,	PUNCT
ctmj-148	249	6	kon	kon	PROPN
ctmj-148	249	7	,	,	PUNCT
ctmj-148	249	8	and	and	CCONJ
ctmj-148	249	9	sugiyama	sugiyama	NOUN
ctmj-148	249	10	.	.	PUNCT
ctmj-148	250	1	a	a	DET
ctmj-148	250	2	novel	novel	ADJ
ctmj-148	250	3	target	target	NOUN
ctmj-148	250	4	for	for	ADP
ctmj-148	250	5	the	the	DET
ctmj-148	250	6	treatment	treatment	NOUN
ctmj-148	250	7	of	of	ADP
ctmj-148	250	8	diarrhoea	diarrhoea	NOUN
ctmj-148	250	9	and	and	CCONJ
ctmj-148	250	10	constipation	constipation	NOUN
ctmj-148	250	11	:	:	PUNCT
ctmj-148	250	12	aquaporins	aquaporin	NOUN
ctmj-148	250	13	in	in	ADP
ctmj-148	250	14	the	the	DET
ctmj-148	250	15	colon	colon	NOUN
ctmj-148	250	16	.	.	PUNCT
ctmj-148	251	1	due	due	ADP
ctmj-148	251	2	to	to	ADP
ctmj-148	251	3	elevated	elevated	ADJ
ctmj-148	251	4	pge2	pge2	NOUN
ctmj-148	251	5	release	release	NOUN
ctmj-148	251	6	from	from	ADP
ctmj-148	251	7	macrophages	macrophage	NOUN
ctmj-148	251	8	,	,	PUNCT
ctmj-148	251	9	aquaporin-3	aquaporin-3	DET
ctmj-148	251	10	expression	expression	NOUN
ctmj-148	251	11	in	in	ADP
ctmj-148	251	12	the	the	DET
ctmj-148	251	13	colon	colon	NOUN
ctmj-148	251	14	is	be	AUX
ctmj-148	251	15	reduced	reduce	VERB
ctmj-148	251	16	(	(	PUNCT
ctmj-148	251	17	int	int	PROPN
ctmj-148	251	18	j	j	PROPN
ctmj-148	251	19	mol	mol	ADP
ctmj-148	251	20	sci	sci	PROPN
ctmj-148	251	21	.	.	PUNCT
ctmj-148	252	1	2016;17(7):e1172	2016;17(7):e1172	NUM
ctmj-148	252	2	)	)	PUNCT
ctmj-148	252	3	.	.	PUNCT
ctmj-148	253	1	u.s	u.s	PROPN
ctmj-148	253	2	.	.	PROPN
ctmj-148	253	3	journal	journal	PROPN
ctmj-148	253	4	of	of	ADP
ctmj-148	253	5	physiology	physiology	NOUN
ctmj-148	253	6	journal	journal	NOUN
ctmj-148	253	7	of	of	ADP
ctmj-148	253	8	gastrointestinal	gastrointestinal	ADJ
ctmj-148	253	9	and	and	CCONJ
ctmj-148	253	10	hepatobiliary	hepatobiliary	ADJ
ctmj-148	253	11	physiology	physiology	NOUN
ctmj-148	253	12	.	.	PUNCT
ctmj-148	254	1	2011;301(5):g887eg895	2011;301(5):g887eg895	NUM
ctmj-148	254	2	.	.	NOUN
ctmj-148	254	3	14	14	NUM
ctmj-148	254	4	.	.	PUNCT
ctmj-148	254	5	kohland	kohland	PROPN
ctmj-148	254	6	de	de	PROPN
ctmj-148	254	7	.	.	PUNCT
ctmj-148	254	8	use	use	NOUN
ctmj-148	254	9	of	of	ADP
ctmj-148	254	10	enzyme	enzyme	NOUN
ctmj-148	254	11	specificity	specificity	NOUN
ctmj-148	254	12	theory	theory	NOUN
ctmj-148	254	13	in	in	ADP
ctmj-148	254	14	protein	protein	NOUN
ctmj-148	254	15	synthesis	synthesis	NOUN
ctmj-148	254	16	.	.	PUNCT
ctmj-148	255	1	the	the	DET
ctmj-148	255	2	publication	publication	NOUN
ctmj-148	255	3	is	be	AUX
ctmj-148	255	4	"	"	PUNCT
ctmj-148	255	5	proc	proc	PROPN
ctmj-148	255	6	natl	natl	PROPN
ctmj-148	255	7	acad	acad	PROPN
ctmj-148	255	8	sci	sci	PROPN
ctmj-148	255	9	u	u	PROPN
ctmj-148	255	10	s	s	NOUN
ctmj-148	255	11	a.	a.	NOUN
ctmj-148	255	12	1958;44(2):98e104	1958;44(2):98e104	PROPN
ctmj-148	255	13	.	.	PUNCT
ctmj-148	255	14	"	"	PUNCT
ctmj-148	256	1	14	14	NUM
ctmj-148	256	2	.	.	PUNCT
ctmj-148	257	1	yang	yang	PROPN
ctmj-148	257	2	xw	xw	PROPN
ctmj-148	257	3	.	.	PUNCT
ctmj-148	258	1	a	a	DET
ctmj-148	258	2	method	method	NOUN
ctmj-148	258	3	for	for	ADP
ctmj-148	258	4	discovering	discover	VERB
ctmj-148	258	5	the	the	DET
ctmj-148	258	6	active	active	ADJ
ctmj-148	258	7	and	and	CCONJ
ctmj-148	258	8	beneficial	beneficial	ADJ
ctmj-148	258	9	components	component	NOUN
ctmj-148	258	10	of	of	ADP
ctmj-148	258	11	chinese	chinese	ADJ
ctmj-148	258	12	medicinal	medicinal	ADJ
ctmj-148	258	13	herbs	herb	NOUN
ctmj-148	258	14	by	by	ADP
ctmj-148	258	15	studying	study	VERB
ctmj-148	258	16	their	their	PRON
ctmj-148	258	17	metabolism	metabolism	NOUN
ctmj-148	258	18	and	and	CCONJ
ctmj-148	258	19	intra	intra	ADJ
ctmj-148	258	20	-	-	ADJ
ctmj-148	258	21	body	body	ADJ
ctmj-148	258	22	distribution	distribution	NOUN
ctmj-148	258	23	.	.	PUNCT
ctmj-148	259	1	“	"	PUNCT
ctmj-148	259	2	zhongguo	zhongguo	PROPN
ctmj-148	259	3	zhongyao	zhongyao	NOUN
ctmj-148	259	4	zazhi	zazhi	PROPN
ctmj-148	259	5	”	"	PUNCT
ctmj-148	260	1	[	[	X
ctmj-148	260	2	chinese	chinese	X
ctmj-148	260	3	]	]	PUNCT
ctmj-148	260	4	2007	2007	NUM
ctmj-148	260	5	;	;	PUNCT
ctmj-148	260	6	32(5	32(5	NUM
ctmj-148	260	7	):	):	PUNCT
ctmj-148	260	8	365–370	365–370	NUM
ctmj-148	260	9	.	.	PUNCT
ctmj-148	261	1	16	16	NUM
ctmj-148	261	2	.	.	PUNCT
ctmj-148	262	1	the	the	DET
ctmj-148	262	2	commission	commission	NOUN
ctmj-148	262	3	for	for	ADP
ctmj-148	262	4	the	the	DET
ctmj-148	262	5	chinese	chinese	ADJ
ctmj-148	262	6	pharmacopoeia	pharmacopoeia	NOUN
ctmj-148	262	7	.	.	PUNCT
ctmj-148	263	1	chapter	chapter	NOUN
ctmj-148	263	2	1	1	NUM
ctmj-148	263	3	of	of	ADP
ctmj-148	263	4	the	the	DET
ctmj-148	263	5	people	people	NOUN
ctmj-148	263	6	's	's	PART
ctmj-148	263	7	republic	republic	NOUN
ctmj-148	263	8	of	of	ADP
ctmj-148	263	9	china	china	PROPN
ctmj-148	263	10	pharmacopoeia	pharmacopoeia	PROPN
ctmj-148	263	11	was	be	AUX
ctmj-148	263	12	published	publish	VERB
ctmj-148	263	13	in	in	ADP
ctmj-148	263	14	2015	2015	NUM
ctmj-148	263	15	by	by	ADP
ctmj-148	263	16	china	china	PROPN
ctmj-148	263	17	medical	medical	PROPN
ctmj-148	263	18	science	science	PROPN
ctmj-148	263	19	press	press	PROPN
ctmj-148	263	20	in	in	ADP
ctmj-148	263	21	beijing	beijing	PROPN
ctmj-148	263	22	,	,	PUNCT
ctmj-148	263	23	china	china	PROPN
ctmj-148	263	24	.	.	PUNCT
ctmj-148	264	1	the	the	DET
ctmj-148	264	2	isbn	isbn	NOUN
ctmj-148	264	3	for	for	ADP
ctmj-148	264	4	this	this	DET
ctmj-148	264	5	volume	volume	NOUN
ctmj-148	264	6	is	be	AUX
ctmj-148	264	7	2015:391.this	2015:391.this	NUM
ctmj-148	264	8	work	work	NOUN
ctmj-148	264	9	is	be	AUX
ctmj-148	264	10	by	by	ADP
ctmj-148	264	11	zhang	zhang	PROPN
ctmj-148	264	12	yg	yg	PROPN
ctmj-148	264	13	,	,	PUNCT
ctmj-148	264	14	ge	ge	PROPN
ctmj-148	264	15	tr	tr	VERB
ctmj-148	264	16	,	,	PUNCT
ctmj-148	264	17	xiang	xiang	PROPN
ctmj-148	264	18	p	p	X
ctmj-148	264	19	,	,	PUNCT
ctmj-148	264	20	and	and	CCONJ
ctmj-148	264	21	others	other	NOUN
ctmj-148	264	22	.	.	PUNCT
ctmj-148	265	1	pharmacological	pharmacological	ADJ
ctmj-148	265	2	treatment	treatment	NOUN
ctmj-148	265	3	of	of	ADP
ctmj-148	265	4	loperamideinduced	loperamideinduce	VERB
ctmj-148	265	5	constipation	constipation	NOUN
ctmj-148	265	6	in	in	ADP
ctmj-148	265	7	sprague	sprague	NOUN
ctmj-148	265	8	-	-	PUNCT
ctmj-148	265	9	dawley	dawley	NOUN
ctmj-148	265	10	rats	rat	NOUN
ctmj-148	265	11	and	and	CCONJ
ctmj-148	265	12	its	its	PRON
ctmj-148	265	13	underlying	underlying	ADJ
ctmj-148	265	14	mechanism	mechanism	NOUN
ctmj-148	265	15	using	use	VERB
ctmj-148	265	16	the	the	DET
ctmj-148	265	17	sligrl	sligrl	NOUN
ctmj-148	265	18	-	-	PUNCT
ctmj-148	265	19	nh2	nh2	NOUN
ctmj-148	265	20	protease	protease	NOUN
ctmj-148	265	21	receptor	receptor	NOUN
ctmj-148	265	22	2	2	NUM
ctmj-148	265	23	agonist	agonist	NOUN
ctmj-148	265	24	.	.	PUNCT
ctmj-148	266	1	article	article	NOUN
ctmj-148	266	2	18	18	NUM
ctmj-148	266	3	.	.	PUNCT
ctmj-148	267	1	qin	qin	PROPN
ctmj-148	267	2	y	y	PROPN
ctmj-148	267	3	,	,	PUNCT
ctmj-148	267	4	wang	wang	PROPN
ctmj-148	267	5	jb	jb	PROPN
ctmj-148	267	6	,	,	PUNCT
ctmj-148	267	7	kong	kong	PROPN
ctmj-148	267	8	wj	wj	PROPN
ctmj-148	267	9	,	,	PUNCT
ctmj-148	267	10	et	et	PROPN
ctmj-148	267	11	al	al	PROPN
ctmj-148	267	12	.	.	PUNCT
ctmj-148	268	1	(	(	PUNCT
ctmj-148	268	2	2018	2018	NUM
ctmj-148	268	3	)	)	PUNCT
ctmj-148	268	4	in	in	ADP
ctmj-148	268	5	drug	drug	NOUN
ctmj-148	268	6	development	development	NOUN
ctmj-148	268	7	and	and	CCONJ
ctmj-148	268	8	therapeutics	therapeutic	NOUN
ctmj-148	268	9	,	,	PUNCT
ctmj-148	268	10	volume	volume	NOUN
ctmj-148	268	11	12	12	NUM
ctmj-148	268	12	,	,	PUNCT
ctmj-148	268	13	pages	page	NOUN
ctmj-148	268	14	2403	2403	NUM
ctmj-148	268	15	–	–	PUNCT
ctmj-148	268	16	2411	2411	NUM
ctmj-148	268	17	.	.	PUNCT
ctmj-148	269	1	the	the	DET
ctmj-148	269	2	possible	possible	ADJ
ctmj-148	269	3	mechanism	mechanism	NOUN
ctmj-148	269	4	of	of	ADP
ctmj-148	269	5	rhubarb	rhubarb	NOUN
ctmj-148	269	6	's	's	PART
ctmj-148	269	7	diarrhoeogenic	diarrhoeogenic	ADJ
ctmj-148	269	8	and	and	CCONJ
ctmj-148	269	9	antidiarrheal	antidiarrheal	ADJ
ctmj-148	269	10	dual	dual	ADJ
ctmj-148	269	11	actions	action	NOUN
ctmj-148	269	12	.	.	PUNCT
ctmj-148	270	1	in	in	ADP
ctmj-148	270	2	a	a	DET
ctmj-148	270	3	2011	2011	NUM
ctmj-148	270	4	article	article	NOUN
ctmj-148	270	5	published	publish	VERB
ctmj-148	270	6	in	in	ADP
ctmj-148	270	7	the	the	DET
ctmj-148	270	8	journal	journal	NOUN
ctmj-148	270	9	of	of	ADP
ctmj-148	270	10	ethnopharmacology	ethnopharmacology	NOUN
ctmj-148	270	11	,	,	PUNCT
ctmj-148	270	12	the	the	DET
ctmj-148	270	13	authors	author	NOUN
ctmj-148	270	14	xu	xu	PROPN
ctmj-148	270	15	y	y	PROPN
ctmj-148	270	16	,	,	PUNCT
ctmj-148	270	17	zhang	zhang	PROPN
ctmj-148	270	18	l	l	PROPN
ctmj-148	270	19	,	,	PUNCT
ctmj-148	270	20	wang	wang	PROPN
ctmj-148	270	21	q	q	PROPN
ctmj-148	270	22	,	,	PUNCT
ctmj-148	270	23	luo	luo	PROPN
ctmj-148	270	24	g	g	PROPN
ctmj-148	270	25	,	,	PUNCT
ctmj-148	270	26	and	and	CCONJ
ctmj-148	270	27	gao	gao	PROPN
ctmj-148	270	28	xy	xy	PROPN
ctmj-148	270	29	discussed	discuss	VERB
ctmj-148	270	30	...	...	PUNCT
ctmj-148	270	31	case	case	NOUN
ctmj-148	270	32	study	study	NOUN
ctmj-148	270	33	:	:	PUNCT
ctmj-148	270	34	rhubarb	rhubarb	NOUN
ctmj-148	270	35	,	,	PUNCT
ctmj-148	270	36	a	a	DET
ctmj-148	270	37	natural	natural	ADJ
ctmj-148	270	38	plant	plant	NOUN
ctmj-148	270	39	-	-	PUNCT
ctmj-148	270	40	derived	derive	VERB
ctmj-148	270	41	component	component	NOUN
ctmj-148	270	42	in	in	ADP
ctmj-148	270	43	rats	rat	NOUN
ctmj-148	270	44	,	,	PUNCT
ctmj-148	270	45	and	and	CCONJ
ctmj-148	270	46	an	an	DET
ctmj-148	270	47	integrated	integrated	ADJ
ctmj-148	270	48	approach	approach	NOUN
ctmj-148	270	49	based	base	VERB
ctmj-148	270	50	on	on	ADP
ctmj-148	270	51	characteristic	characteristic	ADJ
ctmj-148	270	52	fragment	fragment	NOUN
ctmj-148	270	53	filter	filter	NOUN
ctmj-148	270	54	and	and	CCONJ
ctmj-148	270	55	multivariate	multivariate	VERB
ctmj-148	270	56	statistical	statistical	ADJ
ctmj-148	270	57	analysis	analysis	NOUN
ctmj-148	270	58	in	in	ADP
ctmj-148	270	59	multistage	multistage	NOUN
ctmj-148	270	60	mass	mass	NOUN
ctmj-148	270	61	spectrometry	spectrometry	NOUN
ctmj-148	270	62	chromatograms	chromatogram	NOUN
ctmj-148	270	63	for	for	ADP
ctmj-148	270	64	large	large	ADJ
ctmj-148	270	65	-	-	PUNCT
ctmj-148	270	66	scale	scale	NOUN
ctmj-148	270	67	detection	detection	NOUN
ctmj-148	270	68	and	and	CCONJ
ctmj-148	270	69	identification	identification	NOUN
ctmj-148	270	70	.	.	PUNCT
ctmj-148	271	1	in	in	ADP
ctmj-148	271	2	a	a	DET
ctmj-148	271	3	2019	2019	NUM
ctmj-148	271	4	article	article	NOUN
ctmj-148	271	5	published	publish	VERB
ctmj-148	271	6	in	in	ADP
ctmj-148	271	7	the	the	DET
ctmj-148	271	8	journal	journal	NOUN
ctmj-148	271	9	of	of	ADP
ctmj-148	271	10	pharmaceutical	pharmaceutical	NOUN
ctmj-148	271	11	and	and	CCONJ
ctmj-148	271	12	biomedical	biomedical	ADJ
ctmj-148	271	13	anals	anal	NOUN
ctmj-148	271	14	,	,	PUNCT
ctmj-148	271	15	gotfryd	gotfryd	PROPN
ctmj-148	271	16	k	k	NOUN
ctmj-148	271	17	,	,	PUNCT
ctmj-148	271	18	mo'sca	mo'sca	PROPN
ctmj-148	271	19	af	af	PROPN
ctmj-148	271	20	,	,	PUNCT
ctmj-148	271	21	missel	missel	PROPN
ctmj-148	271	22	jw	jw	PROPN
ctmj-148	271	23	,	,	PUNCT
ctmj-148	271	24	and	and	CCONJ
ctmj-148	271	25	colleagues	colleague	NOUN
ctmj-148	271	26	(	(	PUNCT
ctmj-148	271	27	20	20	NUM
ctmj-148	271	28	)	)	PUNCT
ctmj-148	271	29	delve	delve	VERB
ctmj-148	271	30	into	into	ADP
ctmj-148	271	31	the	the	DET
ctmj-148	271	32	topic	topic	NOUN
ctmj-148	271	33	.	.	PUNCT
ctmj-148	272	1	an	an	DET
ctmj-148	272	2	aqp10	aqp10	NOUN
ctmj-148	272	3	ph	ph	ADJ
ctmj-148	272	4	gate	gate	NOUN
ctmj-148	272	5	controls	control	VERB
ctmj-148	272	6	the	the	DET
ctmj-148	272	7	flux	flux	NOUN
ctmj-148	272	8	of	of	ADP
ctmj-148	272	9	adipose	adipose	ADJ
ctmj-148	272	10	glycerol	glycerol	NOUN
ctmj-148	272	11	in	in	ADP
ctmj-148	272	12	humans	human	NOUN
ctmj-148	272	13	.	.	PUNCT
ctmj-148	273	1	kettle	kettle	NOUN
ctmj-148	273	2	jg	jg	PROPN
ctmj-148	273	3	,	,	PUNCT
ctmj-148	273	4	anjum	anjum	PROPN
ctmj-148	273	5	r	r	PROPN
ctmj-148	273	6	,	,	PUNCT
ctmj-148	273	7	barry	barry	PROPN
ctmj-148	273	8	e	e	PROPN
ctmj-148	273	9	,	,	PUNCT
ctmj-148	273	10	et	et	PROPN
ctmj-148	273	11	al	al	PROPN
ctmj-148	273	12	.	.	PROPN
ctmj-148	273	13	published	publish	VERB
ctmj-148	273	14	their	their	PRON
ctmj-148	273	15	findings	finding	NOUN
ctmj-148	273	16	in	in	ADP
ctmj-148	273	17	the	the	DET
ctmj-148	273	18	journal	journal	NOUN
ctmj-148	273	19	nature	nature	NOUN
ctmj-148	273	20	communications	communication	NOUN
ctmj-148	273	21	in	in	ADP
ctmj-148	273	22	2018	2018	NUM
ctmj-148	273	23	with	with	ADP
ctmj-148	273	24	the	the	DET
ctmj-148	273	25	doi	doi	NOUN
ctmj-148	273	26	:	:	PUNCT
ctmj-148	273	27	9.1379	9.1379	NUM
ctmj-148	273	28	.	.	PUNCT
ctmj-148	274	1	the	the	DET
ctmj-148	274	2	development	development	NOUN
ctmj-148	274	3	of	of	ADP
ctmj-148	274	4	azd3229	azd3229	NOUN
ctmj-148	274	5	,	,	PUNCT
ctmj-148	274	6	a	a	DET
ctmj-148	274	7	powerful	powerful	ADJ
ctmj-148	274	8	inhibitor	inhibitor	NOUN
ctmj-148	274	9	of	of	ADP
ctmj-148	274	10	pan	pan	ADJ
ctmj-148	274	11	-	-	ADJ
ctmj-148	274	12	kit	kit	ADJ
ctmj-148	274	13	mutants	mutant	NOUN
ctmj-148	274	14	,	,	PUNCT
ctmj-148	274	15	has	have	AUX
ctmj-148	274	16	improved	improve	VERB
ctmj-148	274	17	the	the	DET
ctmj-148	274	18	prognosis	prognosis	NOUN
ctmj-148	274	19	for	for	ADP
ctmj-148	274	20	gastrointestinal	gastrointestinal	ADJ
ctmj-148	274	21	stromal	stromal	ADJ
ctmj-148	274	22	tumours	tumour	NOUN
ctmj-148	274	23	.	.	PUNCT
ctmj-148	275	1	article	article	NOUN
ctmj-148	275	2	published	publish	VERB
ctmj-148	275	3	in	in	ADP
ctmj-148	275	4	the	the	DET
ctmj-148	275	5	journal	journal	NOUN
ctmj-148	275	6	of	of	ADP
ctmj-148	275	7	medical	medical	ADJ
ctmj-148	275	8	chemistry	chemistry	NOUN
ctmj-148	275	9	in	in	ADP
ctmj-148	275	10	2018	2018	NUM
ctmj-148	275	11	with	with	ADP
ctmj-148	275	12	the	the	DET
ctmj-148	275	13	doi	doi	NOUN
ctmj-148	275	14	:	:	PUNCT
ctmj-148	275	15	8797e8810	8797e8810	NUM
ctmj-148	275	16	.	.	PUNCT
ctmj-148	276	1	chapter	chapter	NOUN
ctmj-148	276	2	22.a	22.a	NUM
ctmj-148	276	3	group	group	NOUN
ctmj-148	276	4	including	include	VERB
ctmj-148	276	5	wang	wang	PROPN
ctmj-148	276	6	,	,	PUNCT
ctmj-148	276	7	lu	lu	PROPN
ctmj-148	276	8	,	,	PUNCT
ctmj-148	276	9	zhang	zhang	PROPN
ctmj-148	276	10	,	,	PUNCT
ctmj-148	276	11	and	and	CCONJ
ctmj-148	276	12	others	other	NOUN
ctmj-148	276	13	...	...	PUNCT
ctmj-148	276	14	using	use	VERB
ctmj-148	276	15	highperformance	highperformance	NOUN
ctmj-148	276	16	liquid	liquid	ADJ
ctmj-148	276	17	chromatography	chromatography	NOUN
ctmj-148	276	18	(	(	PUNCT
ctmj-148	276	19	hplc	hplc	PROPN
ctmj-148	276	20	)	)	PUNCT
ctmj-148	276	21	in	in	ADP
ctmj-148	276	22	conjunction	conjunction	NOUN
ctmj-148	276	23	with	with	ADP
ctmj-148	276	24	linear	linear	ADJ
ctmj-148	276	25	ion	ion	NOUN
ctmj-148	276	26	traporbitrap	traporbitrap	NOUN
ctmj-148	276	27	mass	mass	ADJ
ctmj-148	276	28	spectrometry	spectrometry	NOUN
ctmj-148	276	29	to	to	PART
ctmj-148	276	30	quickly	quickly	ADV
ctmj-148	276	31	detect	detect	VERB
ctmj-148	276	32	and	and	CCONJ
ctmj-148	276	33	identify	identify	VERB
ctmj-148	276	34	components	component	NOUN
ctmj-148	276	35	in	in	ADP
ctmj-148	276	36	rhubarb	rhubarb	NOUN
ctmj-148	276	37	by	by	ADP
ctmj-148	276	38	the	the	DET
ctmj-148	276	39	use	use	NOUN
ctmj-148	276	40	of	of	ADP
ctmj-148	276	41	distinctive	distinctive	ADJ
ctmj-148	276	42	fragment	fragment	ADJ
ctmj-148	276	43	filtering	filtering	NOUN
ctmj-148	276	44	.	.	PUNCT
ctmj-148	277	1	volume	volume	NOUN
ctmj-148	277	2	40	40	NUM
ctmj-148	277	3	,	,	PUNCT
ctmj-148	277	4	issue	issue	NOUN
ctmj-148	277	5	14	14	NUM
ctmj-148	277	6	,	,	PUNCT
ctmj-148	277	7	pages	page	NOUN
ctmj-148	277	8	2854–2862	2854–2862	NUM
ctmj-148	277	9	,	,	PUNCT
ctmj-148	277	10	journal	journal	NOUN
ctmj-148	277	11	of	of	ADP
ctmj-148	277	12	separation	separation	NOUN
ctmj-148	277	13	science	science	NOUN
ctmj-148	277	14	,	,	PUNCT
ctmj-148	277	15	2017.hirano	2017.hirano	PROPN
ctmj-148	277	16	k	k	NOUN
ctmj-148	277	17	,	,	PUNCT
ctmj-148	277	18	okahira	okahira	VERB
ctmj-148	277	19	m	m	PROPN
ctmj-148	277	20	,	,	PUNCT
ctmj-148	277	21	kubota	kubota	PROPN
ctmj-148	277	22	m	m	PROPN
ctmj-148	277	23	,	,	PUNCT
ctmj-148	277	24	iguchi	iguchi	PROPN
ctmj-148	277	25	k	k	NOUN
ctmj-148	277	26	,	,	PUNCT
ctmj-148	277	27	usui	usui	PROPN
ctmj-148	277	28	s.	s.	PROPN
ctmj-148	277	29	effects	effect	NOUN
ctmj-148	277	30	of	of	ADP
ctmj-148	277	31	magnesium	magnesium	NOUN
ctmj-148	277	32	ion	ion	NOUN
ctmj-148	277	33	on	on	ADP
ctmj-148	277	34	aquaporin	aquaporin	NOUN
ctmj-148	277	35	3	3	NUM
ctmj-148	277	36	gene	gene	NOUN
ctmj-148	277	37	expression	expression	NOUN
ctmj-148	277	38	.	.	PUNCT
ctmj-148	278	1	"	"	PUNCT
ctmj-148	278	2	camilleri	camilleri	PROPN
ctmj-148	278	3	m	m	PROPN
ctmj-148	278	4	,	,	PUNCT
ctmj-148	278	5	ford	ford	PROPN
ctmj-148	278	6	ac	ac	PROPN
ctmj-148	278	7	,	,	PUNCT
ctmj-148	278	8	mawe	mawe	PROPN
ctmj-148	278	9	gm	gm	PROPN
ctmj-148	278	10	,	,	PUNCT
ctmj-148	278	11	et	et	PROPN
ctmj-148	278	12	al	al	PROPN
ctmj-148	278	13	.	.	PROPN
ctmj-148	278	14	chronic	chronic	ADJ
ctmj-148	278	15	constipation	constipation	NOUN
ctmj-148	278	16	.	.	PUNCT
ctmj-148	278	17	"	"	PUNCT
ctmj-148	278	18	european	european	ADJ
ctmj-148	278	19	journal	journal	PROPN
ctmj-148	278	20	of	of	ADP
ctmj-148	278	21	pharmacology	pharmacology	NOUN
ctmj-148	278	22	.	.	PUNCT
ctmj-148	279	1	2008;588(1):26–32	2008;588(1):26–32	X
ctmj-148	279	2	.	.	PUNCT
ctmj-148	280	1	scientific	scientific	ADJ
ctmj-148	280	2	reviews	review	NOUN
ctmj-148	280	3	:	:	PUNCT
ctmj-148	280	4	drug	drug	NOUN
ctmj-148	280	5	primers	primer	NOUN
ctmj-148	280	6	.	.	PUNCT
ctmj-148	281	1	2017;3:17095	2017;3:17095	NUM
ctmj-148	281	2	.	.	PUNCT
ctmj-148	282	1	25.an	25.an	NUM
ctmj-148	282	2	study	study	NOUN
ctmj-148	282	3	and	and	CCONJ
ctmj-148	282	4	evaluation	evaluation	NOUN
ctmj-148	282	5	of	of	ADP
ctmj-148	282	6	the	the	DET
ctmj-148	282	7	efficacy	efficacy	NOUN
ctmj-148	282	8	and	and	CCONJ
ctmj-148	282	9	safety	safety	NOUN
ctmj-148	282	10	of	of	ADP
ctmj-148	282	11	guanylate	guanylate	NOUN
ctmj-148	282	12	cyclase	cyclase	NOUN
ctmj-148	282	13	-	-	PUNCT
ctmj-148	282	14	c	c	NOUN
ctmj-148	282	15	agonists	agonist	NOUN
ctmj-148	282	16	for	for	ADP
ctmj-148	282	17	the	the	DET
ctmj-148	282	18	treatment	treatment	NOUN
ctmj-148	282	19	of	of	ADP
ctmj-148	282	20	chronic	chronic	ADJ
ctmj-148	282	21	idiopathic	idiopathic	ADJ
ctmj-148	282	22	constipation	constipation	NOUN
ctmj-148	282	23	and	and	CCONJ
ctmj-148	282	24	irritable	irritable	ADJ
ctmj-148	282	25	bowel	bowel	NOUN
ctmj-148	282	26	syndrome	syndrome	NOUN
ctmj-148	282	27	with	with	ADP
ctmj-148	282	28	constipation	constipation	NOUN
ctmj-148	282	29	was	be	AUX
ctmj-148	282	30	conducted	conduct	VERB
ctmj-148	282	31	by	by	ADP
ctmj-148	282	32	shah	shah	PROPN
ctmj-148	282	33	ed	ed	PROPN
ctmj-148	282	34	,	,	PUNCT
ctmj-148	282	35	kim	kim	PROPN
ctmj-148	282	36	hm	hm	INTJ
ctmj-148	282	37	,	,	PUNCT
ctmj-148	282	38	and	and	CCONJ
ctmj-148	282	39	schoenfeld	schoenfeld	PROPN
ctmj-148	282	40	p.	p.	PROPN
ctmj-148	282	41	american	american	PROPN
ctmj-148	282	42	ctmj	ctmj	PROPN
ctmj-148	283	1	|	|	ADV
ctmj-148	283	2	traditionalmedicinejournals.com	traditionalmedicinejournals.com	X
ctmj-148	283	3	issn	issn	PROPN
ctmj-148	283	4	:	:	PUNCT
ctmj-148	283	5	2693	2693	NUM
ctmj-148	283	6	6356	6356	NUM
ctmj-148	283	7	2024	2024	NUM
ctmj-148	283	8	|	|	ADV
ctmj-148	283	9	vol	vol	NOUN
ctmj-148	283	10	7	7	NUM
ctmj-148	283	11	|	|	NOUN
ctmj-148	283	12	issue	issue	VERB
ctmj-148	283	13	1	1	NUM
ctmj-148	283	14	journal	journal	NOUN
ctmj-148	283	15	of	of	ADP
ctmj-148	283	16	gastroenterology	gastroenterology	NOUN
ctmj-148	283	17	.	.	PUNCT
ctmj-148	284	1	2018;113(3):329	2018;113(3):329	NUM
ctmj-148	284	2	-	-	SYM
ctmj-148	284	3	338	338	NUM
ctmj-148	284	4	.	.	PUNCT
ctmj-148	285	1	26	26	NUM
ctmj-148	285	2	.	.	PUNCT
ctmj-148	286	1	wedel	wedel	PROPN
ctmj-148	286	2	t	t	PROPN
ctmj-148	286	3	,	,	PUNCT
ctmj-148	286	4	spiegler	spiegler	PROPN
ctmj-148	286	5	j	j	PROPN
ctmj-148	286	6	,	,	PUNCT
ctmj-148	286	7	soellner	soellner	NOUN
ctmj-148	286	8	s	s	PART
ctmj-148	286	9	,	,	PUNCT
ctmj-148	286	10	et	et	PROPN
ctmj-148	286	11	al	al	PROPN
ctmj-148	286	12	.	.	PROPN
ctmj-148	286	13	megacolon	megacolon	NOUN
ctmj-148	286	14	and	and	CCONJ
ctmj-148	286	15	slow	slow	ADJ
ctmj-148	286	16	-	-	PUNCT
ctmj-148	286	17	transit	transit	NOUN
ctmj-148	286	18	constipation	constipation	NOUN
ctmj-148	286	19	are	be	AUX
ctmj-148	286	20	associated	associate	VERB
ctmj-148	286	21	with	with	ADP
ctmj-148	286	22	changes	change	NOUN
ctmj-148	286	23	in	in	ADP
ctmj-148	286	24	the	the	DET
ctmj-148	286	25	interstitial	interstitial	ADJ
ctmj-148	286	26	cells	cell	NOUN
ctmj-148	286	27	of	of	ADP
ctmj-148	286	28	cajal	cajal	ADJ
ctmj-148	286	29	and	and	CCONJ
ctmj-148	286	30	enteric	enteric	ADJ
ctmj-148	286	31	nerves	nerve	NOUN
ctmj-148	286	32	.	.	PUNCT
ctmj-148	287	1	gastroenterology	gastroenterology	NOUN
ctmj-148	287	2	.	.	PUNCT
ctmj-148	288	1	2002;123(5):1459–1467	2002;123(5):1459–1467	NUM
ctmj-148	288	2	.	.	PUNCT
ctmj-148	289	1	27this	27this	NUM
ctmj-148	289	2	is	be	AUX
ctmj-148	289	3	according	accord	VERB
ctmj-148	289	4	to	to	ADP
ctmj-148	289	5	yin	yin	PROPN
ctmj-148	289	6	jq	jq	PROPN
ctmj-148	289	7	,	,	PUNCT
ctmj-148	289	8	liang	liang	PROPN
ctmj-148	289	9	yc	yc	PROPN
ctmj-148	289	10	,	,	PUNCT
ctmj-148	289	11	wang	wang	PROPN
ctmj-148	289	12	dl	dl	PROPN
ctmj-148	289	13	,	,	PUNCT
ctmj-148	289	14	and	and	CCONJ
ctmj-148	289	15	colleagues	colleague	NOUN
ctmj-148	289	16	.	.	PUNCT
ctmj-148	290	1	in	in	ADP
ctmj-148	290	2	loperamide	loperamide	NOUN
ctmj-148	290	3	-	-	PUNCT
ctmj-148	290	4	induced	induce	VERB
ctmj-148	290	5	constipated	constipate	VERB
ctmj-148	290	6	mice	mouse	NOUN
ctmj-148	290	7	,	,	PUNCT
ctmj-148	290	8	naringenin	naringenin	PROPN
ctmj-148	290	9	increases	increase	VERB
ctmj-148	290	10	the	the	DET
ctmj-148	290	11	expression	expression	NOUN
ctmj-148	290	12	levels	level	NOUN
ctmj-148	290	13	of	of	ADP
ctmj-148	290	14	c	c	NOUN
ctmj-148	290	15	-	-	PUNCT
ctmj-148	290	16	kit	kit	NOUN
ctmj-148	290	17	,	,	PUNCT
ctmj-148	290	18	scf	scf	PROPN
ctmj-148	290	19	,	,	PUNCT
ctmj-148	290	20	and	and	CCONJ
ctmj-148	290	21	aquaporin	aquaporin	NOUN
ctmj-148	290	22	3	3	NUM
ctmj-148	290	23	,	,	PUNCT
ctmj-148	290	24	leading	lead	VERB
ctmj-148	290	25	to	to	ADP
ctmj-148	290	26	laxative	laxative	ADJ
ctmj-148	290	27	effects	effect	NOUN
ctmj-148	290	28	.	.	PUNCT
ctmj-148	291	1	scientific	scientific	ADJ
ctmj-148	291	2	reports	report	NOUN
ctmj-148	291	3	in	in	ADP
ctmj-148	291	4	molecular	molecular	ADJ
ctmj-148	291	5	medicine	medicine	NOUN
ctmj-148	291	6	.	.	PUNCT
ctmj-148	292	1	2018;41(2	2018;41(2	NUM
ctmj-148	292	2	):	):	PUNCT
ctmj-148	292	3	649	649	NUM
ctmj-148	292	4	-	-	SYM
ctmj-148	292	5	658	658	NUM
ctmj-148	292	6	.	.	PUNCT
ctmj-148	293	1	28.g	28.g	NUM
ctmj-148	293	2	.	.	PUNCT
ctmj-148	294	1	bassotti	bassotti	NOUN
ctmj-148	294	2	,	,	PUNCT
ctmj-148	294	3	v.	v.	CCONJ
ctmj-148	294	4	villanacci	villanacci	PROPN
ctmj-148	294	5	,	,	PUNCT
ctmj-148	294	6	ca	ca	NOUN
ctmj-148	294	7	maurer	maurer	NOUN
ctmj-148	294	8	,	,	PUNCT
ctmj-148	294	9	and	and	CCONJ
ctmj-148	294	10	others	other	NOUN
ctmj-148	294	11	.	.	PUNCT
ctmj-148	295	1	enteric	enteric	ADJ
ctmj-148	295	2	neuronal	neuronal	ADJ
ctmj-148	295	3	death	death	NOUN
ctmj-148	295	4	and	and	CCONJ
ctmj-148	295	5	glial	glial	ADJ
ctmj-148	295	6	cell	cell	NOUN
ctmj-148	295	7	function	function	NOUN
ctmj-148	295	8	in	in	ADP
ctmj-148	295	9	the	the	DET
ctmj-148	295	10	neuropathogenesis	neuropathogenesis	NOUN
ctmj-148	295	11	of	of	ADP
ctmj-148	295	12	persistent	persistent	ADJ
ctmj-148	295	13	delayed	delay	VERB
ctmj-148	295	14	transit	transit	NOUN
ctmj-148	295	15	constipation	constipation	NOUN
ctmj-148	295	16	.	.	PUNCT
ctmj-148	296	1	ref	ref	NOUN
ctmj-148	296	2	.	.	PUNCT
ctmj-148	296	3	:	:	PUNCT
ctmj-148	297	1	gut	gut	VERB
ctmj-148	297	2	.	.	PUNCT
ctmj-148	298	1	2006;55(1):41–46	2006;55(1):41–46	NUM
ctmj-148	298	2	.	.	NOUN
ctmj-148	298	3	29.in	29.in	NUM
ctmj-148	298	4	individuals	individual	NOUN
ctmj-148	298	5	who	who	PRON
ctmj-148	298	6	are	be	AUX
ctmj-148	298	7	not	not	PART
ctmj-148	298	8	satisfied	satisfied	ADJ
ctmj-148	298	9	with	with	ADP
ctmj-148	298	10	laxatives	laxative	NOUN
ctmj-148	298	11	,	,	PUNCT
ctmj-148	298	12	prucalopride	prucalopride	NOUN
ctmj-148	298	13	(	(	PUNCT
ctmj-148	298	14	resolor	resolor	NOUN
ctmj-148	298	15	)	)	PUNCT
ctmj-148	298	16	is	be	AUX
ctmj-148	298	17	used	use	VERB
ctmj-148	298	18	to	to	PART
ctmj-148	298	19	treat	treat	VERB
ctmj-148	298	20	severe	severe	ADJ
ctmj-148	298	21	persistent	persistent	ADJ
ctmj-148	298	22	constipation	constipation	NOUN
ctmj-148	298	23	(	(	PUNCT
ctmj-148	298	24	tack	tack	NOUN
ctmj-148	298	25	et	et	NOUN
ctmj-148	298	26	al	al	PROPN
ctmj-148	298	27	.	.	PROPN
ctmj-148	298	28	,	,	PUNCT
ctmj-148	298	29	2019	2019	NUM
ctmj-148	298	30	)	)	PUNCT
ctmj-148	298	31	.	.	PUNCT
ctmj-148	299	1	"	"	PUNCT
ctmj-148	299	2	gut	gut	VERB
ctmj-148	299	3	"	"	PUNCT
ctmj-148	299	4	(	(	PUNCT
ctmj-148	299	5	2009	2009	NUM
ctmj-148	299	6	,	,	PUNCT
ctmj-148	299	7	58(3	58(3	NUM
ctmj-148	299	8	):	):	PUNCT
ctmj-148	299	9	357–365	357–365	NUM
ctmj-148	299	10	)	)	PUNCT
ctmj-148	299	11	.	.	PUNCT
ctmj-148	300	1	30.the	30.the	DET
ctmj-148	300	2	authors	author	NOUN
ctmj-148	300	3	of	of	ADP
ctmj-148	300	4	the	the	DET
ctmj-148	300	5	study	study	NOUN
ctmj-148	300	6	include	include	VERB
ctmj-148	300	7	yu	yu	PROPN
ctmj-148	300	8	y	y	PROPN
ctmj-148	300	9	,	,	PUNCT
ctmj-148	300	10	chen	chen	PROPN
ctmj-148	300	11	jh	jh	PROPN
ctmj-148	300	12	,	,	PUNCT
ctmj-148	300	13	li	li	PROPN
ctmj-148	300	14	h	h	PROPN
ctmj-148	300	15	,	,	PUNCT
ctmj-148	300	16	and	and	CCONJ
ctmj-148	300	17	others	other	NOUN
ctmj-148	300	18	.	.	PUNCT
ctmj-148	301	1	regulation	regulation	NOUN
ctmj-148	301	2	of	of	ADP
ctmj-148	301	3	rat	rat	NOUN
ctmj-148	301	4	colonic	colonic	NOUN
ctmj-148	301	5	motility	motility	NOUN
ctmj-148	301	6	by	by	ADP
ctmj-148	301	7	5	5	NUM
ctmj-148	301	8	-	-	PUNCT
ctmj-148	301	9	ht3	ht3	NOUN
ctmj-148	301	10	and	and	CCONJ
ctmj-148	301	11	5	5	NUM
ctmj-148	301	12	-	-	PUNCT
ctmj-148	301	13	ht4	ht4	NOUN
ctmj-148	301	14	receptors	receptor	NOUN
ctmj-148	301	15	.	.	PUNCT
ctmj-148	302	1	journal	journal	PROPN
ctmj-148	302	2	of	of	ADP
ctmj-148	302	3	neuro	neuro	NOUN
ctmj-148	302	4	-	-	PUNCT
ctmj-148	302	5	gastroenterology	gastroenterology	NOUN
ctmj-148	302	6	and	and	CCONJ
ctmj-148	302	7	molecular	molecular	ADJ
ctmj-148	302	8	physiology	physiology	NOUN
ctmj-148	302	9	.	.	PUNCT
ctmj-148	303	1	2015;27(7):914–928	2015;27(7):914–928	X
ctmj-148	303	2	.	.	PUNCT
ctmj-148	304	1	31	31	NUM
ctmj-148	304	2	.	.	PUNCT
ctmj-148	305	1	mostafa	mostafa	PROPN
ctmj-148	305	2	rm	rm	PROPN
ctmj-148	305	3	,	,	PUNCT
ctmj-148	305	4	moustafa	moustafa	PROPN
ctmj-148	305	5	ym	ym	PROPN
ctmj-148	305	6	,	,	PUNCT
ctmj-148	305	7	hamdy	hamdy	PROPN
ctmj-148	305	8	h.	h.	PROPN
ctmj-148	305	9	the	the	DET
ctmj-148	305	10	cajal	cajal	ADJ
ctmj-148	305	11	interstitial	interstitial	ADJ
ctmj-148	305	12	cells	cell	NOUN
ctmj-148	305	13	,	,	PUNCT
ctmj-148	305	14	a	a	DET
ctmj-148	305	15	master	master	NOUN
ctmj-148	305	16	in	in	ADP
ctmj-148	305	17	both	both	DET
ctmj-148	305	18	health	health	NOUN
ctmj-148	305	19	and	and	CCONJ
ctmj-148	305	20	illness	illness	NOUN
ctmj-148	305	21	.	.	PUNCT
ctmj-148	306	1	in	in	ADP
ctmj-148	306	2	a	a	DET
ctmj-148	306	3	2010	2010	NUM
ctmj-148	306	4	article	article	NOUN
ctmj-148	306	5	published	publish	VERB
ctmj-148	306	6	in	in	ADP
ctmj-148	306	7	the	the	DET
ctmj-148	306	8	world	world	NOUN
ctmj-148	306	9	journal	journal	PROPN
ctmj-148	306	10	of	of	ADP
ctmj-148	306	11	gastroenterology	gastroenterology	NOUN
ctmj-148	306	12	,	,	PUNCT
ctmj-148	306	13	the	the	DET
ctmj-148	306	14	authors	author	NOUN
ctmj-148	306	15	parthasarathy	parthasarathy	PROPN
ctmj-148	306	16	g.	g.	PROPN
ctmj-148	306	17	,	,	PUNCT
ctmj-148	306	18	chen	chen	PROPN
ctmj-148	306	19	j.	j.	PROPN
ctmj-148	306	20	,	,	PUNCT
ctmj-148	306	21	chia	chia	PROPN
ctmj-148	306	22	n.	n.	PROPN
ctmj-148	306	23	,	,	PUNCT
ctmj-148	306	24	o'connor	o'connor	PROPN
ctmj-148	306	25	hm	hm	PROPN
ctmj-148	306	26	.	.	PROPN
ctmj-148	306	27	,	,	PUNCT
ctmj-148	306	28	gaskins	gaskins	PROPN
ctmj-148	306	29	hr	hr	PROPN
ctmj-148	306	30	.	.	PROPN
ctmj-148	306	31	,	,	PUNCT
ctmj-148	306	32	and	and	CCONJ
ctmj-148	306	33	bharucha	bharucha	PROPN
ctmj-148	306	34	ae	ae	PROPN
ctmj-148	306	35	.	.	PROPN
ctmj-148	306	36	neuro	neuro	PROPN
ctmj-148	306	37	gastroenterol	gastroenterol	PROPN
ctmj-148	306	38	motil	motil	PROPN
ctmj-148	306	39	.	.	PUNCT
ctmj-148	307	1	2017;29(10):1e10	2017;29(10):1e10	NUM
ctmj-148	307	2	.	.	PUNCT
ctmj-148	308	1	33	33	NUM
ctmj-148	308	2	.	.	PUNCT
ctmj-148	309	1	assessing	assess	VERB
ctmj-148	309	2	faecal	faecal	ADJ
ctmj-148	309	3	microbiota	microbiota	NOUN
ctmj-148	309	4	in	in	ADP
ctmj-148	309	5	chronic	chronic	ADJ
ctmj-148	309	6	constipation	constipation	NOUN
ctmj-148	309	7	:	:	PUNCT
ctmj-148	309	8	a	a	DET
ctmj-148	309	9	reproducible	reproducible	ADJ
ctmj-148	309	10	research	research	NOUN
ctmj-148	309	11	method.john	method.john	NOUN
ctmj-148	309	12	galligan	galligan	VERB
ctmj-148	309	13	and	and	CCONJ
ctmj-148	309	14	pan	pan	PROPN
ctmj-148	309	15	h.	h.	PROPN
ctmj-148	309	16	enteric	enteric	ADJ
ctmj-148	309	17	neurons	neuron	NOUN
ctmj-148	309	18	inhibit	inhibit	VERB
ctmj-148	309	19	and	and	CCONJ
ctmj-148	309	20	facilitate	facilitate	VERB
ctmj-148	309	21	rapid	rapid	ADJ
ctmj-148	309	22	synaptic	synaptic	ADJ
ctmj-148	309	23	transmission	transmission	NOUN
ctmj-148	309	24	via	via	ADP
ctmj-148	309	25	5	5	NUM
ctmj-148	309	26	-	-	SYM
ctmj-148	309	27	ht1a	ht1a	PRON
ctmj-148	309	28	and	and	CCONJ
ctmj-148	309	29	5	5	NUM
ctmj-148	309	30	-	-	PUNCT
ctmj-148	309	31	ht4	ht4	NOUN
ctmj-148	309	32	receptors	receptor	NOUN
ctmj-148	309	33	.	.	PUNCT
ctmj-148	310	1	in	in	ADP
ctmj-148	310	2	the	the	DET
ctmj-148	310	3	article	article	NOUN
ctmj-148	310	4	"	"	PUNCT
ctmj-148	310	5	g230eg238	g230eg238	PROPN
ctmj-148	310	6	"	"	PUNCT
ctmj-148	310	7	published	publish	VERB
ctmj-148	310	8	in	in	ADP
ctmj-148	310	9	the	the	DET
ctmj-148	310	10	american	american	ADJ
ctmj-148	310	11	journal	journal	PROPN
ctmj-148	310	12	of	of	ADP
ctmj-148	310	13	physiology	physiology	NOUN
ctmj-148	310	14	in	in	ADP
ctmj-148	310	15	1994	1994	NUM
ctmj-148	310	16	,	,	PUNCT
ctmj-148	310	17	the	the	DET
ctmj-148	310	18	authors	author	NOUN
ctmj-148	310	19	hoffman	hoffman	PROPN
ctmj-148	310	20	,	,	PUNCT
ctmj-148	310	21	tyler	tyler	PROPN
ctmj-148	310	22	,	,	PUNCT
ctmj-148	310	23	maceachern	maceachern	NOUN
ctmj-148	310	24	,	,	PUNCT
ctmj-148	310	25	and	and	CCONJ
ctmj-148	310	26	colleagues	colleague	NOUN
ctmj-148	310	27	were	be	AUX
ctmj-148	310	28	cited	cite	VERB
ctmj-148	310	29	.	.	PUNCT
ctmj-148	311	1	propulsive	propulsive	ADJ
ctmj-148	311	2	motility	motility	NOUN
ctmj-148	311	3	is	be	AUX
ctmj-148	311	4	accelerated	accelerate	VERB
ctmj-148	311	5	and	and	CCONJ
ctmj-148	311	6	visceral	visceral	ADJ
ctmj-148	311	7	hypersensitivity	hypersensitivity	NOUN
ctmj-148	311	8	is	be	AUX
ctmj-148	311	9	inhibited	inhibit	VERB
ctmj-148	311	10	when	when	SCONJ
ctmj-148	311	11	5	5	NUM
ctmj-148	311	12	-	-	PUNCT
ctmj-148	311	13	ht(4	ht(4	NOUN
ctmj-148	311	14	)	)	PUNCT
ctmj-148	311	15	receptors	receptor	NOUN
ctmj-148	311	16	in	in	ADP
ctmj-148	311	17	the	the	DET
ctmj-148	311	18	intestinal	intestinal	ADJ
ctmj-148	311	19	mucosa	mucosa	NOUN
ctmj-148	311	20	are	be	AUX
ctmj-148	311	21	activated	activate	VERB
ctmj-148	311	22	.	.	PUNCT
ctmj-148	312	1	laforenza	laforenza	PROPN
ctmj-148	312	2	u.	u.	PROPN
ctmj-148	312	3	water	water	PROPN
ctmj-148	312	4	channel	channel	NOUN
ctmj-148	312	5	proteins	protein	NOUN
ctmj-148	312	6	in	in	ADP
ctmj-148	312	7	the	the	DET
ctmj-148	312	8	gastrointestinal	gastrointestinal	ADJ
ctmj-148	312	9	tract	tract	NOUN
ctmj-148	312	10	.	.	PUNCT
ctmj-148	313	1	gastroenterology	gastroenterology	NOUN
ctmj-148	313	2	.	.	PUNCT
ctmj-148	314	1	2012;142(4):844e854	2012;142(4):844e854	NUM
ctmj-148	314	2	.	.	PUNCT
ctmj-148	314	3	e4	e4	PROPN
ctmj-148	314	4	.	.	PUNCT
ctmj-148	315	1	(	(	PUNCT
ctmj-148	315	2	kon	kon	PROPN
ctmj-148	315	3	r	r	PROPN
ctmj-148	315	4	,	,	PUNCT
ctmj-148	315	5	ikarashi	ikarashi	PROPN
ctmj-148	315	6	n	n	NOUN
ctmj-148	315	7	,	,	PUNCT
ctmj-148	315	8	hayakawa	hayakawa	PROPN
ctmj-148	315	9	a	a	PROPN
ctmj-148	315	10	,	,	PUNCT
ctmj-148	315	11	et	et	PROPN
ctmj-148	315	12	al	al	PROPN
ctmj-148	315	13	.	.	PROPN
ctmj-148	315	14	)	)	PUNCT
ctmj-148	316	1	published	publish	VERB
ctmj-148	316	2	in	in	ADP
ctmj-148	316	3	mol	mol	ADP
ctmj-148	316	4	aspect	aspect	NOUN
ctmj-148	316	5	med	me	VERB
ctmj-148	316	6	in	in	ADP
ctmj-148	316	7	2012	2012	NUM
ctmj-148	316	8	,	,	PUNCT
ctmj-148	316	9	volume	volume	NOUN
ctmj-148	316	10	33	33	NUM
ctmj-148	316	11	,	,	PUNCT
ctmj-148	316	12	issue	issue	NOUN
ctmj-148	316	13	6	6	NUM
ctmj-148	316	14	,	,	PUNCT
ctmj-148	316	15	pages	page	VERB
ctmj-148	316	16	642–650	642–650	NUM
ctmj-148	316	17	.	.	PUNCT
ctmj-148	317	1	an	an	DET
ctmj-148	317	2	increase	increase	NOUN
ctmj-148	317	3	in	in	ADP
ctmj-148	317	4	serotonin	serotonin	NOUN
ctmj-148	317	5	release	release	NOUN
ctmj-148	317	6	leads	lead	VERB
ctmj-148	317	7	to	to	ADP
ctmj-148	317	8	an	an	DET
ctmj-148	317	9	upregulation	upregulation	NOUN
ctmj-148	317	10	of	of	ADP
ctmj-148	317	11	aquaporin-3	aquaporin-3	PRON
ctmj-148	317	12	in	in	ADP
ctmj-148	317	13	the	the	DET
ctmj-148	317	14	colon	colon	NOUN
ctmj-148	317	15	,	,	PUNCT
ctmj-148	317	16	which	which	PRON
ctmj-148	317	17	in	in	ADP
ctmj-148	317	18	turn	turn	NOUN
ctmj-148	317	19	causes	cause	VERB
ctmj-148	317	20	morphine	morphine	NOUN
ctmj-148	317	21	-	-	PUNCT
ctmj-148	317	22	induced	induce	VERB
ctmj-148	317	23	constipation	constipation	NOUN
ctmj-148	317	24	.	.	PUNCT
ctmj-148	318	1	citation	citation	NOUN
ctmj-148	318	2	:	:	PUNCT
ctmj-148	318	3	toxicol	toxicol	PROPN
ctmj-148	318	4	sci	sci	PROPN
ctmj-148	318	5	.	.	PUNCT
ctmj-148	319	1	2015;145(2):337e347	2015;145(2):337e347	ADJ
ctmj-148	319	2	.	.	PUNCT
ctmj-148	320	1	37.kon	37.kon	PROPN
ctmj-148	320	2	r	r	PROPN
ctmj-148	320	3	,	,	PUNCT
ctmj-148	320	4	nagoya	nagoya	PROPN
ctmj-148	320	5	c	c	PROPN
ctmj-148	320	6	,	,	PUNCT
ctmj-148	320	7	ikarashi	ikarashi	PROPN
ctmj-148	320	8	n	n	CCONJ
ctmj-148	320	9	,	,	PUNCT
ctmj-148	320	10	et	et	PROPN
ctmj-148	320	11	al	al	PROPN
ctmj-148	320	12	.	.	PROPN
ctmj-148	320	13	rheinanthrone	rheinanthrone	PROPN
ctmj-148	320	14	,	,	PUNCT
ctmj-148	320	15	a	a	DET
ctmj-148	320	16	sennoside	sennoside	NOUN
ctmj-148	320	17	a	a	DET
ctmj-148	320	18	metabolite	metabolite	NOUN
ctmj-148	320	19	,	,	PUNCT
ctmj-148	320	20	is	be	AUX
ctmj-148	320	21	responsible	responsible	ADJ
ctmj-148	320	22	for	for	ADP
ctmj-148	320	23	the	the	DET
ctmj-148	320	24	laxative	laxative	NOUN
ctmj-148	320	25	effects	effect	NOUN
ctmj-148	320	26	of	of	ADP
ctmj-148	320	27	rhubarb	rhubarb	NOUN
ctmj-148	320	28	extract	extract	NOUN
ctmj-148	320	29	by	by	ADP
ctmj-148	320	30	activating	activate	VERB
ctmj-148	320	31	macrophages	macrophage	NOUN
ctmj-148	320	32	and	and	CCONJ
ctmj-148	320	33	reducing	reduce	VERB
ctmj-148	320	34	aquaporin-3	aquaporin-3	DET
ctmj-148	320	35	expression	expression	NOUN
ctmj-148	320	36	in	in	ADP
ctmj-148	320	37	the	the	DET
ctmj-148	320	38	colon	colon	NOUN
ctmj-148	320	39	.	.	PUNCT
ctmj-148	321	1	citation	citation	NOUN
ctmj-148	321	2	:	:	PUNCT
ctmj-148	321	3	38	38	NUM
ctmj-148	321	4	.	.	PUNCT
ctmj-148	322	1	zong	zong	PROPN
ctmj-148	322	2	cl	cl	PROPN
ctmj-148	322	3	,	,	PUNCT
ctmj-148	322	4	huang	huang	PROPN
ctmj-148	322	5	rr	rr	PROPN
ctmj-148	322	6	,	,	PUNCT
ctmj-148	322	7	condac	condac	PROPN
ctmj-148	322	8	e	e	PROPN
ctmj-148	322	9	,	,	PUNCT
ctmj-148	322	10	et	et	PROPN
ctmj-148	322	11	al	al	PROPN
ctmj-148	322	12	.	.	PROPN
ctmj-148	323	1	j	j	PROPN
ctmj-148	323	2	ethnopharmacol	ethnopharmacol	PROPN
ctmj-148	323	3	.	.	PUNCT
ctmj-148	324	1	2014;152(1):190e200	2014;152(1):190e200	NUM
ctmj-148	324	2	.	.	PUNCT
ctmj-148	324	3	discovering	discover	VERB
ctmj-148	324	4	robo1	robo1	PROPN
ctmj-148	324	5	's	's	PART
ctmj-148	324	6	heparan	heparan	ADJ
ctmj-148	324	7	sulphate	sulphate	NOUN
ctmj-148	324	8	ligand	ligand	NOUN
ctmj-148	324	9	needs	need	NOUN
ctmj-148	324	10	by	by	ADP
ctmj-148	324	11	an	an	DET
ctmj-148	324	12	integrated	integrated	ADJ
ctmj-148	324	13	approach	approach	NOUN
ctmj-148	324	14	.	.	PUNCT
ctmj-148	325	1	journal	journal	NOUN
ctmj-148	325	2	of	of	ADP
ctmj-148	325	3	the	the	DET
ctmj-148	325	4	american	american	PROPN
ctmj-148	325	5	chemical	chemical	PROPN
ctmj-148	325	6	society	society	NOUN
ctmj-148	325	7	,	,	PUNCT
ctmj-148	325	8	2016;138(39	2016;138(39	NUM
ctmj-148	325	9	):	):	PUNCT
ctmj-148	325	10	13059–13067	13059–13067	NUM
ctmj-148	325	11	.	.	X
ctmj-148	325	12	39	39	NUM
ctmj-148	325	13	.	.	PUNCT
ctmj-148	326	1	zhang	zhang	PROPN
ctmj-148	326	2	y	y	PROPN
ctmj-148	326	3	,	,	PUNCT
ctmj-148	326	4	wang	wang	PROPN
ctmj-148	326	5	zh	zh	PROPN
ctmj-148	326	6	,	,	PUNCT
ctmj-148	326	7	ma	ma	PROPN
ctmj-148	326	8	xy	xy	PROPN
ctmj-148	326	9	,	,	PUNCT
ctmj-148	326	10	et	et	PROPN
ctmj-148	326	11	al	al	PROPN
ctmj-148	326	12	.	.	PROPN
ctmj-148	326	13	glycyrrhetinic	glycyrrhetinic	ADJ
ctmj-148	326	14	acid	acid	NOUN
ctmj-148	326	15	blocks	block	NOUN
ctmj-148	326	16	raseffector	raseffector	NOUN
ctmj-148	326	17	protein	protein	NOUN
ctmj-148	326	18	interactions	interaction	NOUN
ctmj-148	326	19	by	by	ADP
ctmj-148	326	20	binding	bind	VERB
ctmj-148	326	21	to	to	ADP
ctmj-148	326	22	the	the	DET
ctmj-148	326	23	conserved	conserved	ADJ
ctmj-148	326	24	p	p	ADJ
ctmj-148	326	25	-	-	PUNCT
ctmj-148	326	26	loop	loop	NOUN
ctmj-148	326	27	region	region	NOUN
ctmj-148	326	28	.	.	PUNCT
ctmj-148	327	1	the	the	DET
ctmj-148	327	2	article	article	NOUN
ctmj-148	327	3	"	"	PUNCT
ctmj-148	327	4	acta	acta	PROPN
ctmj-148	327	5	pharm	pharm	PROPN
ctmj-148	327	6	sin	sin	PROPN
ctmj-148	327	7	b.	b.	PROPN
ctmj-148	327	8	2019;9(2):294	2019;9(2):294	NUM
ctmj-148	327	9	"	"	PUNCT
ctmj-148	327	10	addresses	address	NOUN
ctmj-148	327	11	this	this	DET
ctmj-148	327	12	2	2	NUM
ctmj-148	327	13	.	.	PUNCT
ctmj-148	327	14	topic	topic	NOUN
ctmj-148	327	15	.	.	PUNCT