id	sid	tid	token	lemma	pos
ctmj-149	1	1	influence	influence	NOUN
ctmj-149	1	2	of	of	ADP
ctmj-149	1	3	puerarin	puerarin	NOUN
ctmj-149	1	4	,	,	PUNCT
ctmj-149	1	5	paeoniflorin	paeoniflorin	NOUN
ctmj-149	1	6	,	,	PUNCT
ctmj-149	1	7	and	and	CCONJ
ctmj-149	1	8	menthol	menthol	NOUN
ctmj-149	1	9	on	on	ADP
ctmj-149	1	10	structure	structure	NOUN
ctmj-149	1	11	and	and	CCONJ
ctmj-149	1	12	barrier	barrier	NOUN
ctmj-149	1	13	function	function	NOUN
ctmj-149	1	14	of	of	ADP
ctmj-149	1	15	tight	tight	ADJ
ctmj-149	1	16	junctions	junction	NOUN
ctmj-149	1	17	in	in	ADP
ctmj-149	1	18	mdck	mdck	PROPN
ctmj-149	1	19	and	and	CCONJ
ctmj-149	1	20	mdck	mdck	PROPN
ctmj-149	1	21	-	-	PUNCT
ctmj-149	1	22	mdr1	mdr1	PROPN
ctmj-149	1	23	cells	cell	NOUN
ctmj-149	1	24	ctmj	ctmj	VERB
ctmj-149	1	25	|	|	ADV
ctmj-149	1	26	traditionalmedicinejournals.com	traditionalmedicinejournals.com	X
ctmj-149	1	27	chinese	chinese	ADJ
ctmj-149	1	28	traditional	traditional	ADJ
ctmj-149	1	29	medicine	medicine	NOUN
ctmj-149	1	30	journal	journal	NOUN
ctmj-149	1	31	|	|	ADV
ctmj-149	1	32	2024	2024	NUM
ctmj-149	1	33	|	|	ADV
ctmj-149	1	34	vol	vol	NOUN
ctmj-149	1	35	7	7	NUM
ctmj-149	1	36	|	|	NOUN
ctmj-149	1	37	issue	issue	VERB
ctmj-149	1	38	1	1	NUM
ctmj-149	1	39	issn	issn	X
ctmj-149	1	40	:	:	PUNCT
ctmj-149	1	41	2693	2693	NUM
ctmj-149	1	42	6356	6356	NUM
ctmj-149	1	43	2024	2024	NUM
ctmj-149	1	44	|	|	ADV
ctmj-149	1	45	vol	vol	NOUN
ctmj-149	1	46	1	1	NUM
ctmj-149	1	47	|	|	ADV
ctmj-149	1	48	issue	issue	VERB
ctmj-149	1	49	1	1	NUM
ctmj-149	1	50	influence	influence	NOUN
ctmj-149	1	51	of	of	ADP
ctmj-149	1	52	puerarin	puerarin	NOUN
ctmj-149	1	53	,	,	PUNCT
ctmj-149	1	54	paeoniflorin	paeoniflorin	NOUN
ctmj-149	1	55	,	,	PUNCT
ctmj-149	1	56	and	and	CCONJ
ctmj-149	1	57	menthol	menthol	NOUN
ctmj-149	1	58	on	on	ADP
ctmj-149	1	59	structure	structure	NOUN
ctmj-149	1	60	and	and	CCONJ
ctmj-149	1	61	barrier	barrier	NOUN
ctmj-149	1	62	function	function	NOUN
ctmj-149	1	63	of	of	ADP
ctmj-149	1	64	tight	tight	ADJ
ctmj-149	1	65	junctions	junction	NOUN
ctmj-149	1	66	in	in	ADP
ctmj-149	1	67	mdck	mdck	PROPN
ctmj-149	1	68	and	and	CCONJ
ctmj-149	1	69	mdck	mdck	PROPN
ctmj-149	1	70	-	-	PUNCT
ctmj-149	1	71	mdr	mdr	PROPN
ctmj-149	1	72	1	1	NUM
ctmj-149	1	73	cells	cell	NOUN
ctmj-149	1	74	lin	lin	PROPN
ctmj-149	1	75	zhang	zhang	PROPN
ctmj-149	1	76	,	,	PUNCT
ctmj-149	1	77	shouying	shouye	VERB
ctmj-149	1	78	duao	duao	PROPN
ctmj-149	1	79	*	*	PROPN
ctmj-149	1	80	,	,	PUNCT
ctmj-149	1	81	yang	yang	PROPN
ctmj-149	1	82	lui	lui	PROPN
ctmj-149	1	83	*	*	PROPN
ctmj-149	1	84	*	*	PROPN
ctmj-149	1	85	,	,	PUNCT
ctmj-149	1	86	chang	chang	PROPN
ctmj-149	1	87	lqiu	lqiu	PROPN
ctmj-149	1	88	,	,	PUNCT
ctmj-149	1	89	huichao	huichao	PROPN
ctmj-149	1	90	,	,	PUNCT
ctmj-149	1	91	bing	bing	NOUN
ctmj-149	1	92	yang	yang	PROPN
ctmj-149	1	93	,	,	PUNCT
ctmj-149	1	94	bai	bai	PROPN
ctmj-149	1	95	,	,	PUNCT
ctmj-149	1	96	pengyue	pengyue	NOUN
ctmj-149	1	97	school	school	NOUN
ctmj-149	1	98	of	of	ADP
ctmj-149	1	99	chinese	chinese	PROPN
ctmj-149	1	100	materia	materia	PROPN
ctmj-149	1	101	medica	medica	PROPN
ctmj-149	1	102	,	,	PUNCT
ctmj-149	1	103	beijing	beijing	PROPN
ctmj-149	1	104	university	university	PROPN
ctmj-149	1	105	of	of	ADP
ctmj-149	1	106	chinese	chinese	ADJ
ctmj-149	1	107	medicine	medicine	NOUN
ctmj-149	1	108	,	,	PUNCT
ctmj-149	1	109	beijing	beijing	PROPN
ctmj-149	1	110	100029	100029	NUM
ctmj-149	1	111	,	,	PUNCT
ctmj-149	1	112	china	china	PROPN
ctmj-149	1	113	introduction	introduction	NOUN
ctmj-149	1	114	medications	medication	NOUN
ctmj-149	1	115	designed	design	VERB
ctmj-149	1	116	to	to	PART
ctmj-149	1	117	target	target	VERB
ctmj-149	1	118	certain	certain	ADJ
ctmj-149	1	119	areas	area	NOUN
ctmj-149	1	120	of	of	ADP
ctmj-149	1	121	the	the	DET
ctmj-149	1	122	brain	brain	NOUN
ctmj-149	1	123	either	either	CCONJ
ctmj-149	1	124	do	do	AUX
ctmj-149	1	125	not	not	PART
ctmj-149	1	126	reach	reach	VERB
ctmj-149	1	127	those	those	DET
ctmj-149	1	128	areas	area	NOUN
ctmj-149	1	129	or	or	CCONJ
ctmj-149	1	130	do	do	AUX
ctmj-149	1	131	not	not	PART
ctmj-149	1	132	reach	reach	VERB
ctmj-149	1	133	enough	enough	ADJ
ctmj-149	1	134	concentrations	concentration	NOUN
ctmj-149	1	135	once	once	SCONJ
ctmj-149	1	136	they	they	PRON
ctmj-149	1	137	do	do	VERB
ctmj-149	1	138	.	.	PUNCT
ctmj-149	2	1	the	the	DET
ctmj-149	2	2	bloodbrain	bloodbrain	NOUN
ctmj-149	2	3	barrier	barrier	NOUN
ctmj-149	2	4	(	(	PUNCT
ctmj-149	2	5	bbb	bbb	NOUN
ctmj-149	2	6	)	)	PUNCT
ctmj-149	2	7	governs	govern	VERB
ctmj-149	2	8	and	and	CCONJ
ctmj-149	2	9	controls	control	VERB
ctmj-149	2	10	the	the	DET
ctmj-149	2	11	molecular	molecular	ADJ
ctmj-149	2	12	permeation	permeation	NOUN
ctmj-149	2	13	between	between	ADP
ctmj-149	2	14	the	the	DET
ctmj-149	2	15	brain	brain	NOUN
ctmj-149	2	16	's	's	PART
ctmj-149	2	17	periphery	periphery	NOUN
ctmj-149	2	18	and	and	CCONJ
ctmj-149	2	19	interior	interior	ADJ
ctmj-149	2	20	,	,	PUNCT
ctmj-149	2	21	and	and	CCONJ
ctmj-149	2	22	when	when	SCONJ
ctmj-149	2	23	the	the	DET
ctmj-149	2	24	levels	level	NOUN
ctmj-149	2	25	of	of	ADP
ctmj-149	2	26	drugs	drug	NOUN
ctmj-149	2	27	administered	administer	VERB
ctmj-149	2	28	to	to	ADP
ctmj-149	2	29	the	the	DET
ctmj-149	2	30	brain	brain	NOUN
ctmj-149	2	31	are	be	AUX
ctmj-149	2	32	inadequate	inadequate	ADJ
ctmj-149	2	33	,	,	PUNCT
ctmj-149	2	34	it	it	PRON
ctmj-149	2	35	is	be	AUX
ctmj-149	2	36	often	often	ADV
ctmj-149	2	37	due	due	ADJ
ctmj-149	2	38	to	to	ADP
ctmj-149	2	39	the	the	DET
ctmj-149	2	40	barrier	barrier	NOUN
ctmj-149	2	41	function	function	NOUN
ctmj-149	2	42	of	of	ADP
ctmj-149	2	43	the	the	DET
ctmj-149	2	44	brain	brain	NOUN
ctmj-149	2	45	's	's	PART
ctmj-149	2	46	capillary	capillary	ADJ
ctmj-149	2	47	endothelial	endothelial	NOUN
ctmj-149	2	48	cells.1e4	cells.1e4	NOUN
ctmj-149	2	49	one	one	NUM
ctmj-149	2	50	of	of	ADP
ctmj-149	2	51	the	the	DET
ctmj-149	2	52	best	good	ADJ
ctmj-149	2	53	cell	cell	NOUN
ctmj-149	2	54	models	model	NOUN
ctmj-149	2	55	to	to	PART
ctmj-149	2	56	mimic	mimic	VERB
ctmj-149	2	57	the	the	DET
ctmj-149	2	58	bbb	bbb	NOUN
ctmj-149	2	59	in	in	ADP
ctmj-149	2	60	vitro	vitro	X
ctmj-149	2	61	is	be	AUX
ctmj-149	2	62	madinedarby	madinedarby	NOUN
ctmj-149	2	63	canine	canine	NOUN
ctmj-149	2	64	kidney	kidney	PROPN
ctmj-149	2	65	epithelial	epithelial	ADJ
ctmj-149	2	66	(	(	PUNCT
ctmj-149	2	67	mdck	mdck	X
ctmj-149	2	68	)	)	PUNCT
ctmj-149	2	69	cells	cell	NOUN
ctmj-149	2	70	or	or	CCONJ
ctmj-149	2	71	mdck	mdck	PROPN
ctmj-149	2	72	cells	cell	NOUN
ctmj-149	2	73	transfected	transfecte	VERB
ctmj-149	2	74	with	with	ADP
ctmj-149	2	75	the	the	DET
ctmj-149	2	76	human	human	ADJ
ctmj-149	2	77	multidrug	multidrug	NOUN
ctmj-149	2	78	resistance	resistance	NOUN
ctmj-149	2	79	1	1	NUM
ctmj-149	2	80	(	(	PUNCT
ctmj-149	2	81	mdr1	mdr1	PROPN
ctmj-149	2	82	)	)	PUNCT
ctmj-149	2	83	gene	gene	NOUN
ctmj-149	2	84	(	(	PUNCT
ctmj-149	2	85	mdck	mdck	PROPN
ctmj-149	2	86	-	-	PUNCT
ctmj-149	2	87	mdr1).5	mdr1).5	PROPN
ctmj-149	2	88	,	,	PUNCT
ctmj-149	2	89	6	6	NUM
ctmj-149	2	90	the	the	DET
ctmj-149	2	91	bbb	bbb	PROPN
ctmj-149	2	92	is	be	AUX
ctmj-149	2	93	a	a	DET
ctmj-149	2	94	barrier	barrier	NOUN
ctmj-149	2	95	system	system	NOUN
ctmj-149	2	96	that	that	PRON
ctmj-149	2	97	keeps	keep	VERB
ctmj-149	2	98	the	the	DET
ctmj-149	2	99	brain	brain	NOUN
ctmj-149	2	100	's	's	PART
ctmj-149	2	101	internal	internal	ADJ
ctmj-149	2	102	environment	environment	NOUN
ctmj-149	2	103	steady	steady	ADJ
ctmj-149	2	104	and	and	CCONJ
ctmj-149	2	105	supports	support	VERB
ctmj-149	2	106	appropriate	appropriate	ADJ
ctmj-149	2	107	brain	brain	NOUN
ctmj-149	2	108	processes	process	NOUN
ctmj-149	2	109	.	.	PUNCT
ctmj-149	3	1	it	it	PRON
ctmj-149	3	2	consists	consist	VERB
ctmj-149	3	3	of	of	ADP
ctmj-149	3	4	a	a	DET
ctmj-149	3	5	single	single	ADJ
ctmj-149	3	6	layer	layer	NOUN
ctmj-149	3	7	of	of	ADP
ctmj-149	3	8	brain	brain	NOUN
ctmj-149	3	9	capillary	capillary	ADJ
ctmj-149	3	10	endothelial	endothelial	NOUN
ctmj-149	3	11	cells	cell	NOUN
ctmj-149	3	12	joined	join	VERB
ctmj-149	3	13	by	by	ADP
ctmj-149	3	14	tight	tight	ADJ
ctmj-149	3	15	junctions	junction	NOUN
ctmj-149	3	16	(	(	PUNCT
ctmj-149	3	17	tjs	tjs	NOUN
ctmj-149	3	18	)	)	PUNCT
ctmj-149	3	19	.	.	PUNCT
ctmj-149	4	1	when	when	SCONJ
ctmj-149	4	2	it	it	PRON
ctmj-149	4	3	comes	come	VERB
ctmj-149	4	4	to	to	ADP
ctmj-149	4	5	molecules	molecule	NOUN
ctmj-149	4	6	that	that	PRON
ctmj-149	4	7	go	go	VERB
ctmj-149	4	8	via	via	ADP
ctmj-149	4	9	the	the	DET
ctmj-149	4	10	paracellular	paracellular	ADJ
ctmj-149	4	11	route	route	NOUN
ctmj-149	4	12	,	,	PUNCT
ctmj-149	4	13	tjs	tjs	NOUN
ctmj-149	4	14	are	be	AUX
ctmj-149	4	15	crucial	crucial	ADJ
ctmj-149	4	16	for	for	ADP
ctmj-149	4	17	molecular	molecular	ADJ
ctmj-149	4	18	permeability	permeability	NOUN
ctmj-149	4	19	of	of	ADP
ctmj-149	4	20	the	the	DET
ctmj-149	4	21	bbb	bbb	PROPN
ctmj-149	4	22	.	.	PUNCT
ctmj-149	5	1	in	in	ADP
ctmj-149	5	2	addition	addition	NOUN
ctmj-149	5	3	to	to	ADP
ctmj-149	5	4	defining	define	VERB
ctmj-149	5	5	cell	cell	NOUN
ctmj-149	5	6	polarity	polarity	NOUN
ctmj-149	5	7	by	by	ADP
ctmj-149	5	8	separating	separate	VERB
ctmj-149	5	9	the	the	DET
ctmj-149	5	10	apical	apical	ADJ
ctmj-149	5	11	and	and	CCONJ
ctmj-149	5	12	basolateral	basolateral	ADJ
ctmj-149	5	13	cell	cell	NOUN
ctmj-149	5	14	surface	surface	NOUN
ctmj-149	5	15	regions	region	NOUN
ctmj-149	5	16	,	,	PUNCT
ctmj-149	5	17	they	they	PRON
ctmj-149	5	18	also	also	ADV
ctmj-149	5	19	serve	serve	VERB
ctmj-149	5	20	as	as	ADP
ctmj-149	5	21	a	a	DET
ctmj-149	5	22	barrier	barrier	NOUN
ctmj-149	5	23	and	and	CCONJ
ctmj-149	5	24	fence.upon	fence.upon	ADP
ctmj-149	5	25	examination	examination	NOUN
ctmj-149	5	26	under	under	ADP
ctmj-149	5	27	electron	electron	NOUN
ctmj-149	5	28	microscopy	microscopy	NOUN
ctmj-149	5	29	,	,	PUNCT
ctmj-149	5	30	transmembrane	transmembrane	ADJ
ctmj-149	5	31	junctions	junction	NOUN
ctmj-149	5	32	(	(	PUNCT
ctmj-149	5	33	tmjs)—which	tmjs)—which	X
ctmj-149	5	34	include	include	VERB
ctmj-149	5	35	integral	integral	ADJ
ctmj-149	5	36	membrane	membrane	NOUN
ctmj-149	5	37	proteins	protein	NOUN
ctmj-149	5	38	—	—	PUNCT
ctmj-149	5	39	are	be	AUX
ctmj-149	5	40	seen	see	VERB
ctmj-149	5	41	as	as	ADP
ctmj-149	5	42	a	a	DET
ctmj-149	5	43	region	region	NOUN
ctmj-149	5	44	of	of	ADP
ctmj-149	5	45	tightly	tightly	ADV
ctmj-149	5	46	connected	connect	VERB
ctmj-149	5	47	abstract	abstract	ADJ
ctmj-149	5	48	—	—	PUNCT
ctmj-149	5	49	to	to	PART
ctmj-149	5	50	find	find	VERB
ctmj-149	5	51	out	out	ADP
ctmj-149	5	52	how	how	SCONJ
ctmj-149	5	53	the	the	DET
ctmj-149	5	54	drugs	drug	NOUN
ctmj-149	5	55	cross	cross	VERB
ctmj-149	5	56	the	the	DET
ctmj-149	5	57	blood	blood	NOUN
ctmj-149	5	58	-	-	PUNCT
ctmj-149	5	59	brain	brain	NOUN
ctmj-149	5	60	barrier	barrier	NOUN
ctmj-149	5	61	(	(	PUNCT
ctmj-149	5	62	bbb	bbb	PROPN
ctmj-149	5	63	)	)	PUNCT
ctmj-149	5	64	,	,	PUNCT
ctmj-149	5	65	this	this	DET
ctmj-149	5	66	study	study	NOUN
ctmj-149	5	67	examined	examine	VERB
ctmj-149	5	68	how	how	SCONJ
ctmj-149	5	69	puerarin	puerarin	NOUN
ctmj-149	5	70	,	,	PUNCT
ctmj-149	5	71	paeoniflorin	paeoniflorin	NOUN
ctmj-149	5	72	,	,	PUNCT
ctmj-149	5	73	and	and	CCONJ
ctmj-149	5	74	menthol	menthol	NOUN
ctmj-149	5	75	affected	affect	VERB
ctmj-149	5	76	the	the	DET
ctmj-149	5	77	structure	structure	NOUN
ctmj-149	5	78	and	and	CCONJ
ctmj-149	5	79	function	function	NOUN
ctmj-149	5	80	of	of	ADP
ctmj-149	5	81	tight	tight	ADJ
ctmj-149	5	82	junctions	junction	NOUN
ctmj-149	5	83	(	(	PUNCT
ctmj-149	5	84	tjs	tjs	NOUN
ctmj-149	5	85	)	)	PUNCT
ctmj-149	5	86	in	in	ADP
ctmj-149	5	87	mdck	mdck	PROPN
ctmj-149	5	88	and	and	CCONJ
ctmj-149	5	89	mdck	mdck	PROPN
ctmj-149	5	90	-	-	PUNCT
ctmj-149	5	91	multi	multi	ADJ
ctmj-149	5	92	-	-	ADJ
ctmj-149	5	93	drug	drug	ADJ
ctmj-149	5	94	resistance	resistance	NOUN
ctmj-149	5	95	1	1	NUM
ctmj-149	5	96	(	(	PUNCT
ctmj-149	5	97	mdr1	mdr1	PROPN
ctmj-149	5	98	)	)	PUNCT
ctmj-149	5	99	cells	cell	NOUN
ctmj-149	5	100	.	.	PUNCT
ctmj-149	6	1	the	the	DET
ctmj-149	6	2	cells	cell	NOUN
ctmj-149	6	3	were	be	AUX
ctmj-149	6	4	first	first	ADV
ctmj-149	6	5	treated	treat	VERB
ctmj-149	6	6	with	with	ADP
ctmj-149	6	7	puerarin	puerarin	NOUN
ctmj-149	6	8	,	,	PUNCT
ctmj-149	6	9	paeoniflorin	paeoniflorin	NOUN
ctmj-149	6	10	,	,	PUNCT
ctmj-149	6	11	and	and	CCONJ
ctmj-149	6	12	menthol	menthol	NOUN
ctmj-149	6	13	.	.	PUNCT
ctmj-149	7	1	then	then	ADV
ctmj-149	7	2	,	,	PUNCT
ctmj-149	7	3	they	they	PRON
ctmj-149	7	4	were	be	AUX
ctmj-149	7	5	stained	stain	VERB
ctmj-149	7	6	with	with	ADP
ctmj-149	7	7	occludin	occludin	PROPN
ctmj-149	7	8	,	,	PUNCT
ctmj-149	7	9	claudin1	claudin1	NOUN
ctmj-149	7	10	,	,	PUNCT
ctmj-149	7	11	and	and	CCONJ
ctmj-149	7	12	f	f	X
ctmj-149	7	13	-	-	PUNCT
ctmj-149	7	14	actin	actin	NOUN
ctmj-149	7	15	using	use	VERB
ctmj-149	7	16	immunohistochemistry	immunohistochemistry	NOUN
ctmj-149	7	17	.	.	PUNCT
ctmj-149	8	1	next	next	ADJ
ctmj-149	8	2	,	,	PUNCT
ctmj-149	8	3	laser	laser	NOUN
ctmj-149	8	4	-	-	PUNCT
ctmj-149	8	5	scanning	scan	VERB
ctmj-149	8	6	confocal	confocal	ADJ
ctmj-149	8	7	microscopy	microscopy	NOUN
ctmj-149	8	8	was	be	AUX
ctmj-149	8	9	used	use	VERB
ctmj-149	8	10	to	to	PART
ctmj-149	8	11	examine	examine	VERB
ctmj-149	8	12	the	the	DET
ctmj-149	8	13	cells	cell	NOUN
ctmj-149	8	14	.	.	PUNCT
ctmj-149	9	1	an	an	DET
ctmj-149	9	2	epithelial	epithelial	ADJ
ctmj-149	9	3	voltage	voltage	NOUN
ctmj-149	9	4	voltmeter	voltmeter	NOUN
ctmj-149	9	5	was	be	AUX
ctmj-149	9	6	used	use	VERB
ctmj-149	9	7	to	to	PART
ctmj-149	9	8	assess	assess	VERB
ctmj-149	9	9	transepithelial	transepithelial	ADJ
ctmj-149	9	10	electrical	electrical	ADJ
ctmj-149	9	11	resistance	resistance	NOUN
ctmj-149	9	12	(	(	PUNCT
ctmj-149	9	13	teer	teer	NOUN
ctmj-149	9	14	)	)	PUNCT
ctmj-149	9	15	,	,	PUNCT
ctmj-149	9	16	and	and	CCONJ
ctmj-149	9	17	imagej	imagej	ADJ
ctmj-149	9	18	software	software	NOUN
ctmj-149	9	19	was	be	AUX
ctmj-149	9	20	used	use	VERB
ctmj-149	9	21	to	to	PART
ctmj-149	9	22	analyse	analyse	VERB
ctmj-149	9	23	the	the	DET
ctmj-149	9	24	average	average	ADJ
ctmj-149	9	25	optical	optical	ADJ
ctmj-149	9	26	density	density	NOUN
ctmj-149	9	27	(	(	PUNCT
ctmj-149	9	28	aod	aod	PROPN
ctmj-149	9	29	)	)	PUNCT
ctmj-149	9	30	of	of	ADP
ctmj-149	9	31	the	the	DET
ctmj-149	9	32	protein	protein	NOUN
ctmj-149	9	33	immunofluorescence	immunofluorescence	NOUN
ctmj-149	9	34	pictures	picture	NOUN
ctmj-149	9	35	.	.	PUNCT
ctmj-149	10	1	the	the	DET
ctmj-149	10	2	results	result	NOUN
ctmj-149	10	3	showed	show	VERB
ctmj-149	10	4	that	that	SCONJ
ctmj-149	10	5	tight	tight	ADJ
ctmj-149	10	6	junction	junction	NOUN
ctmj-149	10	7	proteins	protein	NOUN
ctmj-149	10	8	treated	treat	VERB
ctmj-149	10	9	with	with	ADP
ctmj-149	10	10	puerarin	puerarin	NOUN
ctmj-149	10	11	and	and	CCONJ
ctmj-149	10	12	paeoniflorin	paeoniflorin	NOUN
ctmj-149	10	13	were	be	AUX
ctmj-149	10	14	visible	visible	ADJ
ctmj-149	10	15	under	under	ADP
ctmj-149	10	16	confocal	confocal	ADJ
ctmj-149	10	17	microscopy	microscopy	NOUN
ctmj-149	10	18	,	,	PUNCT
ctmj-149	10	19	but	but	CCONJ
ctmj-149	10	20	menthol	menthol	NOUN
ctmj-149	10	21	reduced	reduce	VERB
ctmj-149	10	22	their	their	PRON
ctmj-149	10	23	expression	expression	NOUN
ctmj-149	10	24	.	.	PUNCT
ctmj-149	11	1	similarly	similarly	ADV
ctmj-149	11	2	,	,	PUNCT
ctmj-149	11	3	the	the	DET
ctmj-149	11	4	menthol	menthol	NOUN
ctmj-149	11	5	group	group	NOUN
ctmj-149	11	6	's	's	PART
ctmj-149	11	7	aod	aod	PROPN
ctmj-149	11	8	value	value	NOUN
ctmj-149	11	9	was	be	AUX
ctmj-149	11	10	downregulated	downregulate	VERB
ctmj-149	11	11	,	,	PUNCT
ctmj-149	11	12	while	while	SCONJ
ctmj-149	11	13	the	the	DET
ctmj-149	11	14	control	control	NOUN
ctmj-149	11	15	group	group	NOUN
ctmj-149	11	16	's	's	PART
ctmj-149	11	17	value	value	NOUN
ctmj-149	11	18	was	be	AUX
ctmj-149	11	19	not	not	PART
ctmj-149	11	20	different	different	ADJ
ctmj-149	11	21	from	from	ADP
ctmj-149	11	22	the	the	DET
ctmj-149	11	23	aod	aod	PROPN
ctmj-149	11	24	values	value	NOUN
ctmj-149	11	25	of	of	ADP
ctmj-149	11	26	cells	cell	NOUN
ctmj-149	11	27	treated	treat	VERB
ctmj-149	11	28	with	with	ADP
ctmj-149	11	29	either	either	CCONJ
ctmj-149	11	30	puerarin	puerarin	NOUN
ctmj-149	11	31	or	or	CCONJ
ctmj-149	11	32	paeoniflorin	paeoniflorin	NOUN
ctmj-149	11	33	,	,	PUNCT
ctmj-149	11	34	or	or	CCONJ
ctmj-149	11	35	both	both	PRON
ctmj-149	11	36	.	.	PUNCT
ctmj-149	12	1	after	after	ADP
ctmj-149	12	2	three	three	NUM
ctmj-149	12	3	hours	hour	NOUN
ctmj-149	12	4	,	,	PUNCT
ctmj-149	12	5	the	the	DET
ctmj-149	12	6	teer	teer	NOUN
ctmj-149	12	7	of	of	ADP
ctmj-149	12	8	cells	cell	NOUN
ctmj-149	12	9	that	that	PRON
ctmj-149	12	10	were	be	AUX
ctmj-149	12	11	not	not	PART
ctmj-149	12	12	exposed	expose	VERB
ctmj-149	12	13	to	to	ADP
ctmj-149	12	14	menthol	menthol	NOUN
ctmj-149	12	15	were	be	AUX
ctmj-149	12	16	comparable	comparable	ADJ
ctmj-149	12	17	to	to	ADP
ctmj-149	12	18	those	those	PRON
ctmj-149	12	19	of	of	ADP
ctmj-149	12	20	the	the	DET
ctmj-149	12	21	control	control	NOUN
ctmj-149	12	22	group	group	NOUN
ctmj-149	12	23	,	,	PUNCT
ctmj-149	12	24	but	but	CCONJ
ctmj-149	12	25	treatment	treatment	NOUN
ctmj-149	12	26	with	with	ADP
ctmj-149	12	27	with	with	ADP
ctmj-149	12	28	a	a	DET
ctmj-149	12	29	p	p	ADJ
ctmj-149	12	30	-	-	PUNCT
ctmj-149	12	31	value	value	NOUN
ctmj-149	12	32	less	less	ADJ
ctmj-149	12	33	than.05	than.05	NOUN
ctmj-149	12	34	,	,	PUNCT
ctmj-149	12	35	menthol	menthol	NOUN
ctmj-149	12	36	considerably	considerably	ADV
ctmj-149	12	37	reduced	reduce	VERB
ctmj-149	12	38	the	the	DET
ctmj-149	12	39	teer	teer	NOUN
ctmj-149	12	40	score	score	NOUN
ctmj-149	12	41	.	.	PUNCT
ctmj-149	13	1	and	and	CCONJ
ctmj-149	13	2	menthol	menthol	NOUN
ctmj-149	13	3	's	's	PART
ctmj-149	13	4	teer	teer	NOUN
ctmj-149	13	5	-	-	PUNCT
ctmj-149	13	6	lowering	lower	VERB
ctmj-149	13	7	effects	effect	NOUN
ctmj-149	13	8	on	on	ADP
ctmj-149	13	9	mdck	mdck	PROPN
ctmj-149	13	10	cells	cell	NOUN
ctmj-149	13	11	were	be	AUX
ctmj-149	13	12	noticed	notice	VERB
ctmj-149	13	13	before	before	ADP
ctmj-149	13	14	those	those	PRON
ctmj-149	13	15	on	on	ADP
ctmj-149	13	16	mdck	mdck	PROPN
ctmj-149	13	17	-	-	PUNCT
ctmj-149	13	18	mdr1	mdr1	PROPN
ctmj-149	13	19	cells	cell	NOUN
ctmj-149	13	20	.	.	PUNCT
ctmj-149	14	1	ultimately	ultimately	ADV
ctmj-149	14	2	,	,	PUNCT
ctmj-149	14	3	it	it	PRON
ctmj-149	14	4	seems	seem	VERB
ctmj-149	14	5	that	that	SCONJ
ctmj-149	14	6	menthol	menthol	NOUN
ctmj-149	14	7	,	,	PUNCT
ctmj-149	14	8	in	in	ADP
ctmj-149	14	9	contrast	contrast	NOUN
ctmj-149	14	10	to	to	ADP
ctmj-149	14	11	puerarin	puerarin	NOUN
ctmj-149	14	12	and	and	CCONJ
ctmj-149	14	13	paeoniflorin	paeoniflorin	NOUN
ctmj-149	14	14	,	,	PUNCT
ctmj-149	14	15	has	have	VERB
ctmj-149	14	16	the	the	DET
ctmj-149	14	17	potential	potential	NOUN
ctmj-149	14	18	to	to	PART
ctmj-149	14	19	decrease	decrease	VERB
ctmj-149	14	20	the	the	DET
ctmj-149	14	21	barrier	barrier	NOUN
ctmj-149	14	22	function	function	NOUN
ctmj-149	14	23	of	of	ADP
ctmj-149	14	24	tjs	tjs	NOUN
ctmj-149	14	25	,	,	PUNCT
ctmj-149	14	26	which	which	PRON
ctmj-149	14	27	in	in	ADP
ctmj-149	14	28	turn	turn	NOUN
ctmj-149	14	29	enhances	enhance	VERB
ctmj-149	14	30	paracellular	paracellular	ADJ
ctmj-149	14	31	transport	transport	NOUN
ctmj-149	14	32	and	and	CCONJ
ctmj-149	14	33	drug	drug	NOUN
ctmj-149	14	34	penetration	penetration	NOUN
ctmj-149	14	35	of	of	ADP
ctmj-149	14	36	the	the	DET
ctmj-149	14	37	bloodbrain	bloodbrain	NOUN
ctmj-149	14	38	barrier	barrier	NOUN
ctmj-149	14	39	.	.	PUNCT
ctmj-149	15	1	membranes	membrane	NOUN
ctmj-149	15	2	at	at	ADP
ctmj-149	15	3	the	the	DET
ctmj-149	15	4	apex	apex	NOUN
ctmj-149	15	5	of	of	ADP
ctmj-149	15	6	neighbouring	neighbouring	NOUN
ctmj-149	15	7	cells	cell	NOUN
ctmj-149	15	8	that	that	PRON
ctmj-149	15	9	face	face	VERB
ctmj-149	15	10	the	the	DET
ctmj-149	15	11	lumen.a	lumen.a	NOUN
ctmj-149	15	12	variety	variety	NOUN
ctmj-149	15	13	of	of	ADP
ctmj-149	15	14	transient	transient	ADJ
ctmj-149	15	15	junction	junction	NOUN
ctmj-149	15	16	proteins	protein	NOUN
ctmj-149	15	17	,	,	PUNCT
ctmj-149	15	18	such	such	ADJ
ctmj-149	15	19	as	as	ADP
ctmj-149	15	20	occludin	occludin	PROPN
ctmj-149	15	21	,	,	PUNCT
ctmj-149	15	22	claudins	claudin	NOUN
ctmj-149	15	23	,	,	PUNCT
ctmj-149	15	24	zona	zona	PROPN
ctmj-149	15	25	occuldens	occulden	NOUN
ctmj-149	15	26	protein	protein	NOUN
ctmj-149	15	27	1	1	NUM
ctmj-149	15	28	(	(	PUNCT
ctmj-149	15	29	zo-1	zo-1	NUM
ctmj-149	15	30	)	)	PUNCT
ctmj-149	15	31	,	,	PUNCT
ctmj-149	15	32	and	and	CCONJ
ctmj-149	15	33	f	f	X
ctmj-149	15	34	-	-	PUNCT
ctmj-149	15	35	actin	actin	NOUN
ctmj-149	15	36	,	,	PUNCT
ctmj-149	15	37	are	be	AUX
ctmj-149	15	38	expressed	express	VERB
ctmj-149	15	39	by	by	ADP
ctmj-149	15	40	mdck	mdck	PROPN
ctmj-149	15	41	and	and	CCONJ
ctmj-149	15	42	mdck	mdck	PROPN
ctmj-149	15	43	-	-	PUNCT
ctmj-149	15	44	mdr1	mdr1	PROPN
ctmj-149	15	45	cells	cell	NOUN
ctmj-149	15	46	because	because	SCONJ
ctmj-149	15	47	their	their	PRON
ctmj-149	15	48	transient	transient	ADJ
ctmj-149	15	49	junction	junction	NOUN
ctmj-149	15	50	structures	structure	NOUN
ctmj-149	15	51	are	be	AUX
ctmj-149	15	52	similar	similar	ADJ
ctmj-149	15	53	to	to	ADP
ctmj-149	15	54	those	those	PRON
ctmj-149	15	55	of	of	ADP
ctmj-149	15	56	brain	brain	NOUN
ctmj-149	15	57	capillary	capillary	ADJ
ctmj-149	15	58	endothelial	endothelial	ADJ
ctmj-149	15	59	cells	cell	NOUN
ctmj-149	15	60	.	.	PUNCT
ctmj-149	16	1	through	through	ADP
ctmj-149	16	2	their	their	PRON
ctmj-149	16	3	hydrophobic	hydrophobic	NOUN
ctmj-149	16	4	barrier	barrier	NOUN
ctmj-149	16	5	function	function	NOUN
ctmj-149	16	6	and	and	CCONJ
ctmj-149	16	7	intramembranous	intramembranous	ADJ
ctmj-149	16	8	fence	fence	NOUN
ctmj-149	16	9	,	,	PUNCT
ctmj-149	16	10	tjs	tjs	NOUN
ctmj-149	16	11	limit	limit	NOUN
ctmj-149	16	12	medication	medication	NOUN
ctmj-149	16	13	delivery	delivery	NOUN
ctmj-149	16	14	to	to	ADP
ctmj-149	16	15	underlying	underlie	VERB
ctmj-149	16	16	tissues	tissue	NOUN
ctmj-149	16	17	and	and	CCONJ
ctmj-149	16	18	reduce	reduce	VERB
ctmj-149	16	19	drug	drug	NOUN
ctmj-149	16	20	permeability	permeability	NOUN
ctmj-149	16	21	of	of	ADP
ctmj-149	16	22	the	the	DET
ctmj-149	16	23	blood	blood	NOUN
ctmj-149	16	24	-	-	PUNCT
ctmj-149	16	25	brain	brain	NOUN
ctmj-149	16	26	barrier	barrier	NOUN
ctmj-149	16	27	(	(	PUNCT
ctmj-149	16	28	bbb	bbb	NOUN
ctmj-149	16	29	)	)	PUNCT
ctmj-149	16	30	.	.	PUNCT
ctmj-149	17	1	some	some	DET
ctmj-149	17	2	medications	medication	NOUN
ctmj-149	17	3	may	may	AUX
ctmj-149	17	4	change	change	VERB
ctmj-149	17	5	the	the	DET
ctmj-149	17	6	structure	structure	NOUN
ctmj-149	17	7	and	and	CCONJ
ctmj-149	17	8	characteristics	characteristic	NOUN
ctmj-149	17	9	of	of	ADP
ctmj-149	17	10	transmembrane	transmembrane	ADJ
ctmj-149	17	11	junctions	junction	NOUN
ctmj-149	17	12	(	(	PUNCT
ctmj-149	17	13	tmjs	tmj	NOUN
ctmj-149	17	14	)	)	PUNCT
ctmj-149	17	15	by	by	ADP
ctmj-149	17	16	acting	act	VERB
ctmj-149	17	17	on	on	ADP
ctmj-149	17	18	tj	tj	NOUN
ctmj-149	17	19	proteins	protein	NOUN
ctmj-149	17	20	to	to	PART
ctmj-149	17	21	make	make	VERB
ctmj-149	17	22	them	they	PRON
ctmj-149	17	23	more	more	ADV
ctmj-149	17	24	permeable	permeable	ADJ
ctmj-149	17	25	to	to	ADP
ctmj-149	17	26	the	the	DET
ctmj-149	17	27	brain	brain	NOUN
ctmj-149	17	28	or	or	CCONJ
ctmj-149	17	29	to	to	ADP
ctmj-149	17	30	other	other	ADJ
ctmj-149	17	31	drugs	drug	NOUN
ctmj-149	17	32	,	,	PUNCT
ctmj-149	17	33	or	or	CCONJ
ctmj-149	17	34	both	both	PRON
ctmj-149	17	35	.	.	PUNCT
ctmj-149	18	1	this	this	PRON
ctmj-149	18	2	is	be	AUX
ctmj-149	18	3	because	because	SCONJ
ctmj-149	18	4	tj	tj	NOUN
ctmj-149	18	5	tightness	tightness	NOUN
ctmj-149	18	6	is	be	AUX
ctmj-149	18	7	dictated	dictate	VERB
ctmj-149	18	8	by	by	ADP
ctmj-149	18	9	the	the	DET
ctmj-149	18	10	protein	protein	NOUN
ctmj-149	18	11	composition	composition	NOUN
ctmj-149	18	12	of	of	ADP
ctmj-149	18	13	the	the	DET
ctmj-149	18	14	webs	webs	NOUN
ctmj-149	18	15	of	of	ADP
ctmj-149	18	16	the	the	DET
ctmj-149	18	17	related	related	ADJ
ctmj-149	18	18	proteinaceous	proteinaceous	ADJ
ctmj-149	18	19	filaments	filament	NOUN
ctmj-149	18	20	(	(	PUNCT
ctmj-149	18	21	called	call	VERB
ctmj-149	18	22	strands	strand	NOUN
ctmj-149	18	23	)	)	PUNCT
ctmj-149	18	24	.	.	PUNCT
ctmj-149	19	1	in	in	ADP
ctmj-149	19	2	order	order	NOUN
ctmj-149	19	3	to	to	PART
ctmj-149	19	4	create	create	VERB
ctmj-149	19	5	medications	medication	NOUN
ctmj-149	19	6	that	that	PRON
ctmj-149	19	7	target	target	VERB
ctmj-149	19	8	the	the	DET
ctmj-149	19	9	brain	brain	NOUN
ctmj-149	19	10	and	and	CCONJ
ctmj-149	19	11	effectively	effectively	ADV
ctmj-149	19	12	cure	cure	NOUN
ctmj-149	19	13	disorders	disorder	NOUN
ctmj-149	19	14	,	,	PUNCT
ctmj-149	19	15	it	it	PRON
ctmj-149	19	16	is	be	AUX
ctmj-149	19	17	crucial	crucial	ADJ
ctmj-149	19	18	to	to	PART
ctmj-149	19	19	research	research	VERB
ctmj-149	19	20	how	how	SCONJ
ctmj-149	19	21	chemicals	chemical	NOUN
ctmj-149	19	22	affect	affect	VERB
ctmj-149	19	23	tj	tj	NOUN
ctmj-149	19	24	proteins	protein	NOUN
ctmj-149	19	25	and	and	CCONJ
ctmj-149	19	26	how	how	SCONJ
ctmj-149	19	27	they	they	PRON
ctmj-149	19	28	may	may	AUX
ctmj-149	19	29	cross	cross	VERB
ctmj-149	19	30	the	the	DET
ctmj-149	19	31	blood	blood	NOUN
ctmj-149	19	32	-	-	PUNCT
ctmj-149	19	33	brain	brain	NOUN
ctmj-149	19	34	barrier	barrier	NOUN
ctmj-149	19	35	(	(	PUNCT
ctmj-149	19	36	bbb	bbb	PROPN
ctmj-149	19	37	)	)	PUNCT
ctmj-149	19	38	.	.	PUNCT
ctmj-149	20	1	an	an	DET
ctmj-149	20	2	essential	essential	ADJ
ctmj-149	20	3	aspect	aspect	NOUN
ctmj-149	20	4	of	of	ADP
ctmj-149	20	5	the	the	DET
ctmj-149	20	6	folkloric	folkloric	ADJ
ctmj-149	20	7	therapeutic	therapeutic	ADJ
ctmj-149	20	8	practice	practice	NOUN
ctmj-149	20	9	is	be	AUX
ctmj-149	20	10	the	the	DET
ctmj-149	20	11	prescription	prescription	NOUN
ctmj-149	20	12	of	of	ADP
ctmj-149	20	13	tongqiaosanyu	tongqiaosanyu	NOUN
ctmj-149	20	14	,	,	PUNCT
ctmj-149	20	15	a	a	DET
ctmj-149	20	16	traditional	traditional	ADJ
ctmj-149	20	17	medicinal	medicinal	ADJ
ctmj-149	20	18	formula	formula	NOUN
ctmj-149	20	19	from	from	ADP
ctmj-149	20	20	china	china	PROPN
ctmj-149	20	21	.	.	PUNCT
ctmj-149	21	1	kudzu	kudzu	PROPN
ctmj-149	21	2	root	root	PROPN
ctmj-149	21	3	(	(	PUNCT
ctmj-149	21	4	pueraria	pueraria	NOUN
ctmj-149	21	5	lobata	lobata	NOUN
ctmj-149	21	6	)	)	PUNCT
ctmj-149	21	7	,	,	PUNCT
ctmj-149	21	8	white	white	ADJ
ctmj-149	21	9	peony	peony	NOUN
ctmj-149	21	10	root	root	NOUN
ctmj-149	21	11	(	(	PUNCT
ctmj-149	21	12	paeonia	paeonia	NOUN
ctmj-149	21	13	albiflora	albiflora	PROPN
ctmj-149	21	14	)	)	PUNCT
ctmj-149	21	15	,	,	PUNCT
ctmj-149	21	16	and	and	CCONJ
ctmj-149	21	17	mint	mint	PROPN
ctmj-149	21	18	(	(	PUNCT
ctmj-149	21	19	mentha	mentha	X
ctmj-149	21	20	hap	hap	PROPN
ctmj-149	21	21	-	-	PUNCT
ctmj-149	21	22	localyx	localyx	ADJ
ctmj-149	21	23	briq	briq	NOUN
ctmj-149	21	24	.	.	PUNCT
ctmj-149	21	25	)	)	PUNCT
ctmj-149	21	26	are	be	AUX
ctmj-149	21	27	among	among	ADP
ctmj-149	21	28	the	the	DET
ctmj-149	21	29	plants	plant	NOUN
ctmj-149	21	30	that	that	PRON
ctmj-149	21	31	make	make	VERB
ctmj-149	21	32	up	up	ADP
ctmj-149	21	33	the	the	DET
ctmj-149	21	34	mix	mix	NOUN
ctmj-149	21	35	.	.	PUNCT
ctmj-149	22	1	tongqiaosanyu	tongqiaosanyu	PROPN
ctmj-149	22	2	is	be	AUX
ctmj-149	22	3	a	a	DET
ctmj-149	22	4	treatment	treatment	NOUN
ctmj-149	22	5	for	for	ADP
ctmj-149	22	6	stroke	stroke	NOUN
ctmj-149	22	7	in	in	ADP
ctmj-149	22	8	china	china	PROPN
ctmj-149	22	9	.	.	PUNCT
ctmj-149	23	1	the	the	DET
ctmj-149	23	2	primary	primary	ADJ
ctmj-149	23	3	active	active	ADJ
ctmj-149	23	4	ingredients	ingredient	NOUN
ctmj-149	23	5	have	have	AUX
ctmj-149	23	6	been	be	AUX
ctmj-149	23	7	determined	determine	VERB
ctmj-149	23	8	to	to	PART
ctmj-149	23	9	be	be	AUX
ctmj-149	23	10	menthol	menthol	NOUN
ctmj-149	23	11	,	,	PUNCT
ctmj-149	23	12	pseudoniflorin	pseudoniflorin	NOUN
ctmj-149	23	13	,	,	PUNCT
ctmj-149	23	14	and	and	CCONJ
ctmj-149	23	15	pierin	pierin	NOUN
ctmj-149	23	16	by	by	ADP
ctmj-149	23	17	pharmacodynamic	pharmacodynamic	ADJ
ctmj-149	23	18	screening	screening	NOUN
ctmj-149	23	19	.	.	PUNCT
ctmj-149	24	1	“	"	PUNCT
ctmj-149	24	2	puerarin	puerarin	X
ctmj-149	24	3	(	(	PUNCT
ctmj-149	24	4	8-[beta	8-[beta	NUM
ctmj-149	24	5	-	-	SYM
ctmj-149	24	6	d	d	NOUN
ctmj-149	24	7	-	-	NOUN
ctmj-149	24	8	glucopyranosyl	glucopyranosyl	NOUN
ctmj-149	24	9	]	]	X
ctmj-149	24	10	“	"	PUNCT
ctmj-149	24	11	-7	-7	INTJ
ctmj-149	24	12	-	-	PUNCT
ctmj-149	24	13	hydroxy-3-[4	hydroxy-3-[4	ADJ
ctmj-149	24	14	hydroxyphenyl]”traditional	hydroxyphenyl]”traditional	NOUN
ctmj-149	24	15	chinese	chinese	ADJ
ctmj-149	24	16	medicine	medicine	NOUN
ctmj-149	24	17	(	(	PUNCT
ctmj-149	24	18	tcm	tcm	PROPN
ctmj-149	24	19	)	)	PUNCT
ctmj-149	24	20	has	have	AUX
ctmj-149	24	21	made	make	VERB
ctmj-149	24	22	extensive	extensive	ADJ
ctmj-149	24	23	use	use	NOUN
ctmj-149	24	24	of	of	ADP
ctmj-149	24	25	-4h-1benzopyran-4	-4h-1benzopyran-4	PROPN
ctmj-149	24	26	-	-	PROPN
ctmj-149	24	27	one	one	NUM
ctmj-149	24	28	(	(	PUNCT
ctmj-149	24	29	c21h20o9	c21h20o9	PROPN
ctmj-149	24	30	)	)	PUNCT
ctmj-149	24	31	,	,	PUNCT
ctmj-149	24	32	the	the	DET
ctmj-149	24	33	main	main	ADJ
ctmj-149	24	34	isoflavone	isoflavone	NOUN
ctmj-149	24	35	glycoside	glycoside	NOUN
ctmj-149	24	36	extracted	extract	VERB
ctmj-149	24	37	from	from	ADP
ctmj-149	24	38	kudzu	kudzu	NOUN
ctmj-149	24	39	root	root	NOUN
ctmj-149	24	40	,	,	PUNCT
ctmj-149	24	41	for	for	ADP
ctmj-149	24	42	the	the	DET
ctmj-149	24	43	treatment	treatment	NOUN
ctmj-149	24	44	of	of	ADP
ctmj-149	24	45	ischemic	ischemic	ADJ
ctmj-149	24	46	stroke	stroke	NOUN
ctmj-149	24	47	and	and	CCONJ
ctmj-149	24	48	cardiovascular	cardiovascular	ADJ
ctmj-149	24	49	diseases.17	diseases.17	NOUN
ctmj-149	24	50	with	with	ADP
ctmj-149	24	51	e19	e19	ADJ
ctmj-149	24	52	5	5	NUM
ctmj-149	24	53	-	-	PUNCT
ctmj-149	24	54	beta-[{benzoyloxy	beta-[{benzoyloxy	ADJ
ctmj-149	24	55	}	}	PUNCT
ctmj-149	24	56	methyl	methyl	NOUN
ctmj-149	24	57	]	]	PUNCT
ctmj-149	24	58	paeoniflorin5,4	paeoniflorin5,4	PROPN
ctmj-149	24	59	-	-	PUNCT
ctmj-149	24	60	dioxacyclobuta[cd	dioxacyclobuta[cd	PROPN
ctmj-149	24	61	]	]	PUNCT
ctmj-149	24	62	tetrahydro-5	tetrahydro-5	PROPN
ctmj-149	24	63	-	-	PUNCT
ctmj-149	24	64	hydroxy-2	hydroxy-2	NOUN
ctmj-149	24	65	-	-	PUNCT
ctmj-149	24	66	methyl-2,5	methyl-2,5	NOUN
ctmj-149	24	67	-	-	PUNCT
ctmj-149	24	68	methano-1h[2h	methano-1h[2h	NOUN
ctmj-149	24	69	]	]	X
ctmj-149	24	70	pentalen-1alphathe	pentalen-1alphathe	PRON
ctmj-149	24	71	monoterpene	monoterpene	PROPN
ctmj-149	24	72	glucoside	glucoside	NOUN
ctmj-149	24	73	iso	iso	NOUN
ctmj-149	24	74	-	-	PUNCT
ctmj-149	24	75	lated	late	VERB
ctmj-149	24	76	from	from	ADP
ctmj-149	24	77	white	white	ADJ
ctmj-149	24	78	peony	peony	NOUN
ctmj-149	24	79	root	root	NOUN
ctmj-149	24	80	is	be	AUX
ctmj-149	24	81	known	know	VERB
ctmj-149	24	82	as	as	ADP
ctmj-149	24	83	-ylbeta	-ylbeta	NOUN
ctmj-149	24	84	-	-	PUNCT
ctmj-149	24	85	d	d	NOUN
ctmj-149	24	86	-	-	PUNCT
ctmj-149	24	87	glucopyranoside	glucopyranoside	NOUN
ctmj-149	24	88	(	(	PUNCT
ctmj-149	24	89	c23h28o11	c23h28o11	PROPN
ctmj-149	24	90	)	)	PUNCT
ctmj-149	24	91	.	.	PUNCT
ctmj-149	25	1	it	it	PRON
ctmj-149	25	2	enhances	enhance	VERB
ctmj-149	25	3	glucose	glucose	NOUN
ctmj-149	25	4	uptake	uptake	NOUN
ctmj-149	25	5	and	and	CCONJ
ctmj-149	25	6	possesses	possess	VERB
ctmj-149	25	7	neuroprotective	neuroprotective	ADJ
ctmj-149	25	8	,	,	PUNCT
ctmj-149	25	9	anti	anti	ADJ
ctmj-149	25	10	-	-	ADJ
ctmj-149	25	11	inflammatory	inflammatory	ADJ
ctmj-149	25	12	,	,	PUNCT
ctmj-149	25	13	anti	anti	ADJ
ctmj-149	25	14	-	-	NOUN
ctmj-149	25	15	allergy	allergy	NOUN
ctmj-149	25	16	,	,	PUNCT
ctmj-149	25	17	and	and	CCONJ
ctmj-149	25	18	antihyperglycemic	antihyperglycemic	ADJ
ctmj-149	25	19	properties.20	properties.20	NOUN
ctmj-149	25	20	the	the	DET
ctmj-149	25	21	chemical	chemical	NOUN
ctmj-149	25	22	formula	formula	NOUN
ctmj-149	25	23	for	for	ADP
ctmj-149	25	24	menthol	menthol	NOUN
ctmj-149	25	25	is	be	AUX
ctmj-149	25	26	c10h20o	c10h20o	PROPN
ctmj-149	25	27	,	,	PUNCT
ctmj-149	25	28	and	and	CCONJ
ctmj-149	25	29	it	it	PRON
ctmj-149	25	30	is	be	AUX
ctmj-149	25	31	a	a	DET
ctmj-149	25	32	primary	primary	ADJ
ctmj-149	25	33	component	component	NOUN
ctmj-149	25	34	of	of	ADP
ctmj-149	25	35	peppermint	peppermint	NOUN
ctmj-149	25	36	oil	oil	NOUN
ctmj-149	25	37	,	,	PUNCT
ctmj-149	25	38	which	which	PRON
ctmj-149	25	39	increases	increase	VERB
ctmj-149	25	40	blood	blood	NOUN
ctmj-149	25	41	-	-	PUNCT
ctmj-149	25	42	brain	brain	NOUN
ctmj-149	25	43	barrier	barrier	NOUN
ctmj-149	25	44	(	(	PUNCT
ctmj-149	25	45	bbb	bbb	NOUN
ctmj-149	25	46	)	)	PUNCT
ctmj-149	25	47	permeation	permeation	NOUN
ctmj-149	25	48	and	and	CCONJ
ctmj-149	25	49	has	have	VERB
ctmj-149	25	50	excitatory	excitatory	ADJ
ctmj-149	25	51	effects	effect	NOUN
ctmj-149	25	52	on	on	ADP
ctmj-149	25	53	the	the	DET
ctmj-149	25	54	central	central	ADJ
ctmj-149	25	55	nervous	nervous	ADJ
ctmj-149	25	56	system	system	NOUN
ctmj-149	25	57	(	(	PUNCT
ctmj-149	25	58	cns).21	cns).21	ADJ
ctmj-149	25	59	analytical	analytical	ADJ
ctmj-149	25	60	methodologies	methodology	NOUN
ctmj-149	25	61	for	for	ADP
ctmj-149	25	62	the	the	DET
ctmj-149	25	63	primary	primary	ADJ
ctmj-149	25	64	active	active	ADJ
ctmj-149	25	65	constituents	constituent	NOUN
ctmj-149	25	66	were	be	AUX
ctmj-149	25	67	developed	develop	VERB
ctmj-149	25	68	in	in	ADP
ctmj-149	25	69	our	our	PRON
ctmj-149	25	70	prior	prior	ADJ
ctmj-149	25	71	examination	examination	NOUN
ctmj-149	25	72	of	of	ADP
ctmj-149	25	73	tongqiaosanyu	tongqiaosanyu	PROPN
ctmj-149	25	74	.	.	PUNCT
ctmj-149	26	1	furthermore	furthermore	ADV
ctmj-149	26	2	,	,	PUNCT
ctmj-149	26	3	we	we	PRON
ctmj-149	26	4	investigated	investigate	VERB
ctmj-149	26	5	the	the	DET
ctmj-149	26	6	in	in	ADP
ctmj-149	26	7	vivo	vivo	ADJ
ctmj-149	26	8	pharmacokinetic	pharmacokinetic	ADJ
ctmj-149	26	9	behaviour	behaviour	NOUN
ctmj-149	26	10	of	of	ADP
ctmj-149	26	11	tongqiaosanyu	tongqiaosanyu	PROPN
ctmj-149	26	12	,	,	PUNCT
ctmj-149	26	13	its	its	PRON
ctmj-149	26	14	compatibility	compatibility	NOUN
ctmj-149	26	15	with	with	ADP
ctmj-149	26	16	other	other	ADJ
ctmj-149	26	17	medications	medication	NOUN
ctmj-149	26	18	,	,	PUNCT
ctmj-149	26	19	and	and	CCONJ
ctmj-149	26	20	several	several	ADJ
ctmj-149	26	21	methods	method	NOUN
ctmj-149	26	22	of	of	ADP
ctmj-149	26	23	administration	administration	NOUN
ctmj-149	26	24	.	.	PUNCT
ctmj-149	27	1	the	the	DET
ctmj-149	27	2	processes	process	NOUN
ctmj-149	27	3	by	by	ADP
ctmj-149	27	4	which	which	PRON
ctmj-149	27	5	puerarin	puerarin	NOUN
ctmj-149	27	6	crosses	cross	VERB
ctmj-149	27	7	the	the	DET
ctmj-149	27	8	blood	blood	NOUN
ctmj-149	27	9	-	-	PUNCT
ctmj-149	27	10	brain	brain	NOUN
ctmj-149	27	11	barrier	barrier	NOUN
ctmj-149	27	12	(	(	PUNCT
ctmj-149	27	13	bbb	bbb	NOUN
ctmj-149	27	14	)	)	PUNCT
ctmj-149	27	15	have	have	AUX
ctmj-149	27	16	been	be	AUX
ctmj-149	27	17	documented	document	VERB
ctmj-149	27	18	,	,	PUNCT
ctmj-149	27	19	as	as	SCONJ
ctmj-149	27	20	have	have	VERB
ctmj-149	27	21	its	its	PRON
ctmj-149	27	22	cytotoxicity	cytotoxicity	NOUN
ctmj-149	27	23	and	and	CCONJ
ctmj-149	27	24	transport	transport	NOUN
ctmj-149	27	25	in	in	ADP
ctmj-149	27	26	mdck	mdck	PROPN
ctmj-149	27	27	and	and	CCONJ
ctmj-149	27	28	mdck	mdck	PROPN
ctmj-149	27	29	-	-	PUNCT
ctmj-149	27	30	mdr1	mdr1	PROPN
ctmj-149	27	31	cells	cell	NOUN
ctmj-149	27	32	.	.	PUNCT
ctmj-149	28	1	nevertheless	nevertheless	ADV
ctmj-149	28	2	,	,	PUNCT
ctmj-149	28	3	it	it	PRON
ctmj-149	28	4	is	be	AUX
ctmj-149	28	5	still	still	ADV
ctmj-149	28	6	not	not	PART
ctmj-149	28	7	known	know	VERB
ctmj-149	28	8	how	how	SCONJ
ctmj-149	28	9	these	these	DET
ctmj-149	28	10	chemicals	chemical	NOUN
ctmj-149	28	11	paracellularly	paracellularly	ADV
ctmj-149	28	12	cross	cross	VERB
ctmj-149	28	13	the	the	DET
ctmj-149	28	14	blood	blood	NOUN
ctmj-149	28	15	-	-	PUNCT
ctmj-149	28	16	brain	brain	NOUN
ctmj-149	28	17	barrier	barrier	NOUN
ctmj-149	28	18	(	(	PUNCT
ctmj-149	28	19	bbb	bbb	PROPN
ctmj-149	28	20	)	)	PUNCT
ctmj-149	28	21	,	,	PUNCT
ctmj-149	28	22	particularly	particularly	ADV
ctmj-149	28	23	how	how	SCONJ
ctmj-149	28	24	they	they	PRON
ctmj-149	28	25	affect	affect	VERB
ctmj-149	28	26	protein	protein	NOUN
ctmj-149	28	27	structure	structure	NOUN
ctmj-149	28	28	and	and	CCONJ
ctmj-149	28	29	barrier	barrier	NOUN
ctmj-149	28	30	function	function	NOUN
ctmj-149	28	31	.	.	PUNCT
ctmj-149	29	1	hence	hence	ADV
ctmj-149	29	2	,	,	PUNCT
ctmj-149	29	3	we	we	PRON
ctmj-149	29	4	aimed	aim	VERB
ctmj-149	29	5	to	to	PART
ctmj-149	29	6	find	find	VERB
ctmj-149	29	7	out	out	ADP
ctmj-149	29	8	how	how	SCONJ
ctmj-149	29	9	this	this	DET
ctmj-149	29	10	formula	formula	NOUN
ctmj-149	29	11	tjs	tjs	NOUN
ctmj-149	29	12	worked	work	VERB
ctmj-149	29	13	and	and	CCONJ
ctmj-149	29	14	what	what	DET
ctmj-149	29	15	part	part	NOUN
ctmj-149	29	16	each	each	DET
ctmj-149	29	17	chemical	chemical	NOUN
ctmj-149	29	18	played	play	VERB
ctmj-149	29	19	in	in	ADP
ctmj-149	29	20	transport	transport	NOUN
ctmj-149	29	21	by	by	ADP
ctmj-149	29	22	simulating	simulate	VERB
ctmj-149	29	23	the	the	DET
ctmj-149	29	24	bbb	bbb	NOUN
ctmj-149	29	25	using	use	VERB
ctmj-149	29	26	mdck	mdck	PROPN
ctmj-149	29	27	and	and	CCONJ
ctmj-149	29	28	mdck	mdck	PROPN
ctmj-149	29	29	-	-	PUNCT
ctmj-149	29	30	mdr1	mdr1	PROPN
ctmj-149	29	31	cells	cell	NOUN
ctmj-149	29	32	.	.	PUNCT
ctmj-149	30	1	researchers	researcher	NOUN
ctmj-149	30	2	looked	look	VERB
ctmj-149	30	3	at	at	ADP
ctmj-149	30	4	how	how	SCONJ
ctmj-149	30	5	these	these	DET
ctmj-149	30	6	medications	medication	NOUN
ctmj-149	30	7	entered	enter	VERB
ctmj-149	30	8	the	the	DET
ctmj-149	30	9	brain	brain	NOUN
ctmj-149	30	10	and	and	CCONJ
ctmj-149	30	11	how	how	SCONJ
ctmj-149	30	12	certain	certain	ADJ
ctmj-149	30	13	medicines	medicine	NOUN
ctmj-149	30	14	improved	improve	VERB
ctmj-149	30	15	their	their	PRON
ctmj-149	30	16	penetration	penetration	NOUN
ctmj-149	30	17	.	.	PUNCT
ctmj-149	31	1	materials	material	NOUN
ctmj-149	31	2	and	and	CCONJ
ctmj-149	31	3	methods	method	NOUN
ctmj-149	31	4	materials	material	NOUN
ctmj-149	31	5	puerarin	puerarin	NOUN
ctmj-149	31	6	,	,	PUNCT
ctmj-149	31	7	paeoniflorin	paeoniflorin	NOUN
ctmj-149	31	8	,	,	PUNCT
ctmj-149	31	9	and	and	CCONJ
ctmj-149	31	10	menthol	menthol	NOUN
ctmj-149	31	11	were	be	AUX
ctmj-149	31	12	purchased	purchase	VERB
ctmj-149	31	13	from	from	ADP
ctmj-149	31	14	the	the	DET
ctmj-149	31	15	national	national	PROPN
ctmj-149	31	16	institute	institute	PROPN
ctmj-149	31	17	for	for	ADP
ctmj-149	31	18	food	food	NOUN
ctmj-149	31	19	and	and	CCONJ
ctmj-149	31	20	drug	drug	NOUN
ctmj-149	31	21	control	control	NOUN
ctmj-149	31	22	(	(	PUNCT
ctmj-149	31	23	beijing	beijing	PROPN
ctmj-149	31	24	,	,	PUNCT
ctmj-149	31	25	china	china	PROPN
ctmj-149	31	26	)	)	PUNCT
ctmj-149	31	27	.	.	PUNCT
ctmj-149	32	1	polyester	polyester	NOUN
ctmj-149	32	2	(	(	PUNCT
ctmj-149	32	3	pet	pet	NOUN
ctmj-149	32	4	)	)	PUNCT
ctmj-149	32	5	cell	cell	NOUN
ctmj-149	32	6	culture	culture	NOUN
ctmj-149	32	7	inserts	insert	NOUN
ctmj-149	32	8	and	and	CCONJ
ctmj-149	32	9	12	12	NUM
ctmj-149	32	10	-	-	PUNCT
ctmj-149	32	11	well	well	NOUN
ctmj-149	32	12	plates	plate	NOUN
ctmj-149	32	13	(	(	PUNCT
ctmj-149	32	14	12	12	NUM
ctmj-149	32	15	-	-	PUNCT
ctmj-149	32	16	mm	mm	NUM
ctmj-149	32	17	diameter	diameter	NOUN
ctmj-149	32	18	,	,	PUNCT
ctmj-149	32	19	0.4	0.4	NUM
ctmj-149	32	20	-	-	PUNCT
ctmj-149	32	21	mm	mm	NOUN
ctmj-149	32	22	pore	pore	ADJ
ctmj-149	32	23	size	size	NOUN
ctmj-149	32	24	)	)	PUNCT
ctmj-149	32	25	were	be	AUX
ctmj-149	32	26	obtained	obtain	VERB
ctmj-149	32	27	from	from	ADP
ctmj-149	32	28	corning	corn	VERB
ctmj-149	32	29	life	life	NOUN
ctmj-149	32	30	sciences	science	NOUN
ctmj-149	32	31	(	(	PUNCT
ctmj-149	32	32	corning	corning	NOUN
ctmj-149	32	33	,	,	PUNCT
ctmj-149	32	34	ny	ny	PROPN
ctmj-149	32	35	,	,	PUNCT
ctmj-149	32	36	usa	usa	PROPN
ctmj-149	32	37	)	)	PUNCT
ctmj-149	32	38	.	.	PUNCT
ctmj-149	33	1	rabbit	rabbit	NOUN
ctmj-149	33	2	antioccludin	antioccludin	VERB
ctmj-149	33	3	antibody	antibody	NOUN
ctmj-149	33	4	(	(	PUNCT
ctmj-149	33	5	ab31721	ab31721	PROPN
ctmj-149	33	6	)	)	PUNCT
ctmj-149	33	7	was	be	AUX
ctmj-149	33	8	obtained	obtain	VERB
ctmj-149	33	9	from	from	ADP
ctmj-149	33	10	abcam	abcam	PROPN
ctmj-149	33	11	shanghai	shanghai	PROPN
ctmj-149	33	12	(	(	PUNCT
ctmj-149	33	13	shanghai	shanghai	PROPN
ctmj-149	33	14	,	,	PUNCT
ctmj-149	33	15	china	china	PROPN
ctmj-149	33	16	)	)	PUNCT
ctmj-149	33	17	.	.	PUNCT
ctmj-149	34	1	mouse	mouse	NOUN
ctmj-149	34	2	anti	anti	ADJ
ctmj-149	34	3	-	-	ADJ
ctmj-149	34	4	claudin-1	claudin-1	ADJ
ctmj-149	34	5	antibody	antibody	NOUN
ctmj-149	34	6	(	(	PUNCT
ctmj-149	34	7	2h10d10	2h10d10	PROPN
ctmj-149	34	8	)	)	PUNCT
ctmj-149	34	9	was	be	AUX
ctmj-149	34	10	purchased	purchase	VERB
ctmj-149	34	11	from	from	ADP
ctmj-149	34	12	invitrogen	invitrogen	PROPN
ctmj-149	34	13	(	(	PUNCT
ctmj-149	34	14	camarillo	camarillo	PROPN
ctmj-149	34	15	,	,	PUNCT
ctmj-149	34	16	ca	ca	PROPN
ctmj-149	34	17	,	,	PUNCT
ctmj-149	34	18	usa	usa	PROPN
ctmj-149	34	19	)	)	PUNCT
ctmj-149	34	20	.	.	PUNCT
ctmj-149	35	1	anti	anti	ADJ
ctmj-149	35	2	-	-	ADJ
ctmj-149	35	3	rabbit	rabbit	ADJ
ctmj-149	35	4	igg	igg	PROPN
ctmj-149	35	5	tetramethylrhodamineisothiocyanate	tetramethylrhodamineisothiocyanate	NOUN
ctmj-149	35	6	(	(	PUNCT
ctmj-149	35	7	tritc	tritc	NOUN
ctmj-149	35	8	)	)	PUNCT
ctmj-149	35	9	conjugate	conjugate	NOUN
ctmj-149	35	10	was	be	AUX
ctmj-149	35	11	purchased	purchase	VERB
ctmj-149	35	12	from	from	ADP
ctmj-149	35	13	zsg	zsg	PROPN
ctmj-149	35	14	-	-	PUNCT
ctmj-149	35	15	bio	bio	NOUN
ctmj-149	35	16	(	(	PUNCT
ctmj-149	35	17	beijing	beijing	PROPN
ctmj-149	35	18	,	,	PUNCT
ctmj-149	35	19	china	china	PROPN
ctmj-149	35	20	)	)	PUNCT
ctmj-149	35	21	.	.	PUNCT
ctmj-149	36	1	antimouse	antimouse	ADJ
ctmj-149	36	2	-	-	PUNCT
ctmj-149	36	3	fluoresceinisothiocyanate	fluoresceinisothiocyanate	ADJ
ctmj-149	36	4	(	(	PUNCT
ctmj-149	36	5	fitc	fitc	NOUN
ctmj-149	36	6	)	)	PUNCT
ctmj-149	36	7	conjugated	conjugate	VERB
ctmj-149	36	8	antibody	antibody	NOUN
ctmj-149	36	9	was	be	AUX
ctmj-149	36	10	purchased	purchase	VERB
ctmj-149	36	11	from	from	ADP
ctmj-149	36	12	kangwei	kangwei	PROPN
ctmj-149	36	13	century	century	PROPN
ctmj-149	36	14	biotechnology	biotechnology	NOUN
ctmj-149	36	15	(	(	PUNCT
ctmj-149	36	16	beijing	beijing	PROPN
ctmj-149	36	17	,	,	PUNCT
ctmj-149	36	18	china	china	PROPN
ctmj-149	36	19	)	)	PUNCT
ctmj-149	36	20	.	.	PUNCT
ctmj-149	37	1	acti	acti	VERB
ctmj-149	37	2	-	-	PUNCT
ctmj-149	37	3	stain	stain	NOUN
ctmj-149	37	4	488	488	NUM
ctmj-149	37	5	phalloidin	phalloidin	NOUN
ctmj-149	37	6	staining	stain	VERB
ctmj-149	37	7	for	for	ADP
ctmj-149	37	8	f	f	PROPN
ctmj-149	37	9	-	-	PUNCT
ctmj-149	37	10	actin	actin	PROPN
ctmj-149	37	11	was	be	AUX
ctmj-149	37	12	obtained	obtain	VERB
ctmj-149	37	13	from	from	ADP
ctmj-149	37	14	cytoskeleton	cytoskeleton	PROPN
ctmj-149	37	15	(	(	PUNCT
ctmj-149	37	16	denver	denver	PROPN
ctmj-149	37	17	,	,	PUNCT
ctmj-149	37	18	co	co	NOUN
ctmj-149	37	19	,	,	PUNCT
ctmj-149	37	20	usa	usa	PROPN
ctmj-149	37	21	)	)	PUNCT
ctmj-149	37	22	.	.	PUNCT
ctmj-149	38	1	cell	cell	NOUN
ctmj-149	38	2	culture	culture	NOUN
ctmj-149	38	3	mdck	mdck	PROPN
ctmj-149	38	4	and	and	CCONJ
ctmj-149	38	5	mdck	mdck	PROPN
ctmj-149	38	6	-	-	PUNCT
ctmj-149	38	7	mdr1	mdr1	PROPN
ctmj-149	38	8	cells	cell	NOUN
ctmj-149	38	9	were	be	AUX
ctmj-149	38	10	generously	generously	ADV
ctmj-149	38	11	provided	provide	VERB
ctmj-149	38	12	by	by	ADP
ctmj-149	38	13	dr	dr	PROPN
ctmj-149	38	14	.	.	PROPN
ctmj-149	38	15	zeng	zeng	PROPN
ctmj-149	38	16	(	(	PUNCT
ctmj-149	38	17	zhejiang	zhejiang	PROPN
ctmj-149	38	18	university	university	PROPN
ctmj-149	38	19	,	,	PUNCT
ctmj-149	38	20	china	china	PROPN
ctmj-149	38	21	)	)	PUNCT
ctmj-149	38	22	.	.	PUNCT
ctmj-149	39	1	both	both	DET
ctmj-149	39	2	cell	cell	NOUN
ctmj-149	39	3	lines	line	NOUN
ctmj-149	39	4	were	be	AUX
ctmj-149	39	5	cultured	cultured	ADJ
ctmj-149	39	6	with	with	ADP
ctmj-149	39	7	dulbecco	dulbecco	NOUN
ctmj-149	39	8	’s	’s	PART
ctmj-149	39	9	modified	modified	PROPN
ctmj-149	39	10	eagle	eagle	PROPN
ctmj-149	39	11	’s	’s	PART
ctmj-149	39	12	media	medium	NOUN
ctmj-149	39	13	(	(	PUNCT
ctmj-149	39	14	dmem	dmem	ADJ
ctmj-149	39	15	)	)	PUNCT
ctmj-149	39	16	supplemented	supplement	VERB
ctmj-149	39	17	with	with	ADP
ctmj-149	39	18	10	10	NUM
ctmj-149	39	19	%	%	NOUN
ctmj-149	39	20	heat	heat	NOUN
ctmj-149	39	21	-	-	PUNCT
ctmj-149	39	22	inactivated	inactivate	VERB
ctmj-149	39	23	fetal	fetal	ADJ
ctmj-149	39	24	bovine	bovine	NOUN
ctmj-149	39	25	serum	serum	NOUN
ctmj-149	39	26	(	(	PUNCT
ctmj-149	39	27	fbs	fbs	PROPN
ctmj-149	39	28	,	,	PUNCT
ctmj-149	39	29	gibco	gibco	NOUN
ctmj-149	39	30	,	,	PUNCT
ctmj-149	39	31	fremont	fremont	PROPN
ctmj-149	39	32	,	,	PUNCT
ctmj-149	39	33	ca	ca	PROPN
ctmj-149	39	34	,	,	PUNCT
ctmj-149	39	35	usa	usa	PROPN
ctmj-149	39	36	)	)	PUNCT
ctmj-149	39	37	,	,	PUNCT
ctmj-149	39	38	100	100	NUM
ctmj-149	39	39	u	u	NOUN
ctmj-149	39	40	/	/	SYM
ctmj-149	39	41	ml	ml	NOUN
ctmj-149	39	42	penicillin	penicillin	NOUN
ctmj-149	39	43	,	,	PUNCT
ctmj-149	39	44	and	and	CCONJ
ctmj-149	39	45	0.1	0.1	NUM
ctmj-149	39	46	mg	mg	NUM
ctmj-149	39	47	/	/	SYM
ctmj-149	39	48	ml	ml	ADP
ctmj-149	39	49	streptomycin	streptomycin	PROPN
ctmj-149	39	50	in	in	ADP
ctmj-149	39	51	a	a	DET
ctmj-149	39	52	humidified	humidify	VERB
ctmj-149	39	53	atmosphere	atmosphere	NOUN
ctmj-149	39	54	of	of	ADP
ctmj-149	39	55	5	5	NUM
ctmj-149	39	56	%	%	NOUN
ctmj-149	39	57	co2	co2	NOUN
ctmj-149	39	58	at	at	ADP
ctmj-149	39	59	37	37	NUM
ctmj-149	39	60	◦	◦	NOUN
ctmj-149	39	61	c.	c.	NOUN
ctmj-149	39	62	the	the	DET
ctmj-149	39	63	medium	medium	NOUN
ctmj-149	39	64	was	be	AUX
ctmj-149	39	65	replaced	replace	VERB
ctmj-149	39	66	with	with	ADP
ctmj-149	39	67	fresh	fresh	ADJ
ctmj-149	39	68	medium	medium	NOUN
ctmj-149	39	69	every	every	DET
ctmj-149	39	70	other	other	ADJ
ctmj-149	39	71	day	day	NOUN
ctmj-149	39	72	until	until	SCONJ
ctmj-149	39	73	the	the	DET
ctmj-149	39	74	cells	cell	NOUN
ctmj-149	39	75	reached	reach	VERB
ctmj-149	39	76	approximately	approximately	ADV
ctmj-149	39	77	90	90	NUM
ctmj-149	39	78	%	%	NOUN
ctmj-149	39	79	confluence	confluence	NOUN
ctmj-149	39	80	.	.	PUNCT
ctmj-149	40	1	grouping	grouping	NOUN
ctmj-149	40	2	and	and	CCONJ
ctmj-149	40	3	drug	drug	PROPN
ctmj-149	40	4	administration	administration	NOUN
ctmj-149	40	5	ctmj	ctmj	NOUN
ctmj-149	40	6	|	|	ADV
ctmj-149	40	7	traditionalmedicinejournals.com	traditionalmedicinejournals.com	X
ctmj-149	40	8	chinese	chinese	ADJ
ctmj-149	40	9	traditional	traditional	ADJ
ctmj-149	40	10	medicine	medicine	NOUN
ctmj-149	40	11	journal	journal	NOUN
ctmj-149	40	12	|	|	ADV
ctmj-149	40	13	2024	2024	NUM
ctmj-149	40	14	|	|	ADV
ctmj-149	40	15	vol	vol	NOUN
ctmj-149	40	16	7	7	NUM
ctmj-149	40	17	|	|	NOUN
ctmj-149	40	18	issue	issue	VERB
ctmj-149	40	19	1	1	NUM
ctmj-149	40	20	issn	issn	X
ctmj-149	40	21	:	:	PUNCT
ctmj-149	40	22	2693	2693	NUM
ctmj-149	40	23	6356	6356	NUM
ctmj-149	40	24	2024	2024	NUM
ctmj-149	40	25	|	|	ADV
ctmj-149	40	26	vol	vol	NOUN
ctmj-149	40	27	1	1	NUM
ctmj-149	40	28	|	|	NOUN
ctmj-149	40	29	issue	issue	VERB
ctmj-149	40	30	1	1	NUM
ctmj-149	40	31	in	in	ADP
ctmj-149	40	32	a	a	DET
ctmj-149	40	33	previous	previous	ADJ
ctmj-149	40	34	study,22	study,22	NOUN
ctmj-149	40	35	the	the	DET
ctmj-149	40	36	cytotoxicity	cytotoxicity	NOUN
ctmj-149	40	37	of	of	ADP
ctmj-149	40	38	puerarin	puerarin	NOUN
ctmj-149	40	39	,	,	PUNCT
ctmj-149	40	40	paeoniflorin	paeoniflorin	NOUN
ctmj-149	40	41	,	,	PUNCT
ctmj-149	40	42	and	and	CCONJ
ctmj-149	40	43	menthol	menthol	NOUN
ctmj-149	40	44	in	in	ADP
ctmj-149	40	45	mdck	mdck	PROPN
ctmj-149	40	46	and	and	CCONJ
ctmj-149	40	47	mdck	mdck	PROPN
ctmj-149	40	48	-	-	PUNCT
ctmj-149	40	49	mdr1	mdr1	PROPN
ctmj-149	40	50	cells	cell	NOUN
ctmj-149	40	51	using	use	VERB
ctmj-149	40	52	3(4,5	3(4,5	PROPN
ctmj-149	40	53	-	-	PUNCT
ctmj-149	40	54	dimethylthiazol-2	dimethylthiazol-2	VERB
ctmj-149	40	55	-	-	PUNCT
ctmj-149	40	56	yl)-2,5diphenyltetr	yl)-2,5diphenyltetr	NOUN
ctmj-149	40	57	-	-	PUNCT
ctmj-149	40	58	azolium	azolium	NOUN
ctmj-149	40	59	bromide	bromide	NOUN
ctmj-149	40	60	(	(	PUNCT
ctmj-149	40	61	mtt	mtt	NOUN
ctmj-149	40	62	)	)	PUNCT
ctmj-149	40	63	assay	assay	VERB
ctmj-149	40	64	.	.	PUNCT
ctmj-149	41	1	results	result	NOUN
ctmj-149	41	2	showed	show	VERB
ctmj-149	41	3	puerarin	puerarin	NOUN
ctmj-149	41	4	,	,	PUNCT
ctmj-149	41	5	paeoniflorin	paeoniflorin	NOUN
ctmj-149	41	6	,	,	PUNCT
ctmj-149	41	7	and	and	CCONJ
ctmj-149	41	8	menthol	menthol	NOUN
ctmj-149	41	9	were	be	AUX
ctmj-149	41	10	not	not	PART
ctmj-149	41	11	cytotoxic	cytotoxic	ADJ
ctmj-149	41	12	at	at	ADP
ctmj-149	41	13	concentration	concentration	NOUN
ctmj-149	41	14	ranges	range	NOUN
ctmj-149	41	15	of	of	ADP
ctmj-149	41	16	0e0.3	0e0.3	NUM
ctmj-149	41	17	mg	mg	PROPN
ctmj-149	41	18	/	/	SYM
ctmj-149	41	19	ml	ml	NOUN
ctmj-149	41	20	,	,	PUNCT
ctmj-149	41	21	0e0.4	0e0.4	NUM
ctmj-149	41	22	mg	mg	NUM
ctmj-149	41	23	/	/	SYM
ctmj-149	41	24	ml	ml	NOUN
ctmj-149	41	25	,	,	PUNCT
ctmj-149	41	26	and	and	CCONJ
ctmj-149	41	27	0e0.04	0e0.04	NUM
ctmj-149	41	28	mg	mg	PROPN
ctmj-149	41	29	/	/	SYM
ctmj-149	41	30	ml	ml	PROPN
ctmj-149	41	31	,	,	PUNCT
ctmj-149	41	32	respec	respec	VERB
ctmj-149	41	33	tively	tively	ADV
ctmj-149	41	34	.	.	PUNCT
ctmj-149	42	1	furthermore	furthermore	ADV
ctmj-149	42	2	,	,	PUNCT
ctmj-149	42	3	puerarin	puerarin	NOUN
ctmj-149	42	4	plus	plus	CCONJ
ctmj-149	42	5	paeoniflorin	paeoniflorin	NOUN
ctmj-149	42	6	(	(	PUNCT
ctmj-149	42	7	1:0.4	1:0.4	NUM
ctmj-149	42	8	w	w	PROPN
ctmj-149	42	9	/	/	SYM
ctmj-149	42	10	v	v	NOUN
ctmj-149	42	11	,	,	PUNCT
ctmj-149	42	12	pp	pp	ADJ
ctmj-149	42	13	)	)	PUNCT
ctmj-149	42	14	,	,	PUNCT
ctmj-149	42	15	puerarin	puerarin	NOUN
ctmj-149	42	16	plus	plus	CCONJ
ctmj-149	42	17	menthol	menthol	NOUN
ctmj-149	42	18	(	(	PUNCT
ctmj-149	42	19	1:0.5	1:0.5	NUM
ctmj-149	42	20	w	w	PROPN
ctmj-149	42	21	/	/	SYM
ctmj-149	42	22	v	v	NOUN
ctmj-149	42	23	,	,	PUNCT
ctmj-149	42	24	pm	pm	NOUN
ctmj-149	42	25	)	)	PUNCT
ctmj-149	42	26	,	,	PUNCT
ctmj-149	42	27	and	and	CCONJ
ctmj-149	42	28	puerarin	puerarin	NOUN
ctmj-149	42	29	plus	plus	CCONJ
ctmj-149	42	30	paeoniflorin	paeoniflorin	NOUN
ctmj-149	42	31	plus	plus	CCONJ
ctmj-149	42	32	menthol	menthol	NOUN
ctmj-149	42	33	(	(	PUNCT
ctmj-149	42	34	1:0.4:0.5	1:0.4:0.5	NUM
ctmj-149	42	35	,	,	PUNCT
ctmj-149	42	36	w	w	NOUN
ctmj-149	42	37	/	/	SYM
ctmj-149	42	38	w	w	PROPN
ctmj-149	42	39	/	/	SYM
ctmj-149	42	40	w	w	PROPN
ctmj-149	42	41	,	,	PUNCT
ctmj-149	42	42	ppm	ppm	ADJ
ctmj-149	42	43	)	)	PUNCT
ctmj-149	42	44	groups	group	NOUN
ctmj-149	42	45	exhibited	exhibit	VERB
ctmj-149	42	46	no	no	DET
ctmj-149	42	47	cytotoxicity	cytotoxicity	NOUN
ctmj-149	42	48	at	at	ADP
ctmj-149	42	49	concentration	concentration	NOUN
ctmj-149	42	50	ranges	range	NOUN
ctmj-149	42	51	of	of	ADP
ctmj-149	42	52	0e0.2	0e0.2	NUM
ctmj-149	42	53	mg	mg	NUM
ctmj-149	42	54	/	/	SYM
ctmj-149	42	55	ml	ml	PROPN
ctmj-149	42	56	(	(	PUNCT
ctmj-149	42	57	paeoniflorin	paeoniflorin	NOUN
ctmj-149	42	58	)	)	PUNCT
ctmj-149	42	59	,	,	PUNCT
ctmj-149	42	60	0e0.05	0e0.05	NOUN
ctmj-149	42	61	mg	mg	PROPN
ctmj-149	42	62	/	/	SYM
ctmj-149	42	63	ml	ml	PROPN
ctmj-149	42	64	(	(	PUNCT
ctmj-149	42	65	menthol	menthol	NOUN
ctmj-149	42	66	)	)	PUNCT
ctmj-149	42	67	,	,	PUNCT
ctmj-149	42	68	and	and	CCONJ
ctmj-149	42	69	0e0.04	0e0.04	NUM
ctmj-149	42	70	mg	mg	PROPN
ctmj-149	42	71	/	/	SYM
ctmj-149	42	72	ml	ml	PROPN
ctmj-149	42	73	(	(	PUNCT
ctmj-149	42	74	menthol	menthol	NOUN
ctmj-149	42	75	)	)	PUNCT
ctmj-149	42	76	,	,	PUNCT
ctmj-149	42	77	respectively	respectively	ADV
ctmj-149	42	78	.	.	PUNCT
ctmj-149	43	1	based	base	VERB
ctmj-149	43	2	on	on	ADP
ctmj-149	43	3	the	the	DET
ctmj-149	43	4	re	re	NOUN
ctmj-149	43	5	sults	sult	NOUN
ctmj-149	43	6	of	of	ADP
ctmj-149	43	7	mtt	mtt	NOUN
ctmj-149	43	8	assay	assay	VERB
ctmj-149	43	9	,	,	PUNCT
ctmj-149	43	10	this	this	DET
ctmj-149	43	11	study	study	NOUN
ctmj-149	43	12	included	include	VERB
ctmj-149	43	13	the	the	DET
ctmj-149	43	14	following	follow	VERB
ctmj-149	43	15	six	six	NUM
ctmj-149	43	16	treatment	treatment	NOUN
ctmj-149	43	17	groups	group	NOUN
ctmj-149	43	18	:	:	PUNCT
ctmj-149	43	19	puerarin	puerarin	NOUN
ctmj-149	43	20	,	,	PUNCT
ctmj-149	43	21	paeoniflorin	paeoniflorin	NOUN
ctmj-149	43	22	,	,	PUNCT
ctmj-149	43	23	and	and	CCONJ
ctmj-149	43	24	menthol	menthol	NOUN
ctmj-149	43	25	(	(	PUNCT
ctmj-149	43	26	0.1	0.1	NUM
ctmj-149	43	27	mg	mg	PROPN
ctmj-149	43	28	/	/	SYM
ctmj-149	43	29	ml	ml	NOUN
ctmj-149	43	30	,	,	PUNCT
ctmj-149	43	31	0.04	0.04	NUM
ctmj-149	43	32	mg	mg	NUM
ctmj-149	43	33	/	/	SYM
ctmj-149	43	34	ml	ml	NOUN
ctmj-149	43	35	,	,	PUNCT
ctmj-149	43	36	and	and	CCONJ
ctmj-149	43	37	0.05	0.05	NUM
ctmj-149	43	38	mg	mg	NUM
ctmj-149	43	39	/	/	SYM
ctmj-149	43	40	ml	ml	NOUN
ctmj-149	43	41	,	,	PUNCT
ctmj-149	43	42	respectively	respectively	ADV
ctmj-149	43	43	)	)	PUNCT
ctmj-149	43	44	,	,	PUNCT
ctmj-149	43	45	as	as	ADV
ctmj-149	43	46	well	well	ADV
ctmj-149	43	47	as	as	ADP
ctmj-149	43	48	the	the	DET
ctmj-149	43	49	pp	pp	PROPN
ctmj-149	43	50	group	group	NOUN
ctmj-149	43	51	(	(	PUNCT
ctmj-149	43	52	0.1	0.1	NUM
ctmj-149	43	53	mg	mg	NUM
ctmj-149	43	54	/	/	SYM
ctmj-149	43	55	ml	ml	AUX
ctmj-149	43	56	puerarin	puerarin	NOUN
ctmj-149	43	57	and	and	CCONJ
ctmj-149	43	58	0.04	0.04	NUM
ctmj-149	43	59	mg/	mg/	NOUN
ctmj-149	43	60	ml	ml	NOUN
ctmj-149	43	61	paeoniflorin	paeoniflorin	NOUN
ctmj-149	43	62	,	,	PUNCT
ctmj-149	43	63	respectively	respectively	ADV
ctmj-149	43	64	)	)	PUNCT
ctmj-149	43	65	,	,	PUNCT
ctmj-149	43	66	pm	pm	NOUN
ctmj-149	43	67	group	group	NOUN
ctmj-149	43	68	(	(	PUNCT
ctmj-149	43	69	0.1	0.1	NUM
ctmj-149	43	70	mg	mg	NUM
ctmj-149	43	71	/	/	SYM
ctmj-149	43	72	ml	ml	NOUN
ctmj-149	43	73	puerarin	puerarin	NOUN
ctmj-149	43	74	and	and	CCONJ
ctmj-149	43	75	0.05	0.05	NUM
ctmj-149	43	76	mg	mg	NUM
ctmj-149	43	77	/	/	SYM
ctmj-149	43	78	ml	ml	NOUN
ctmj-149	43	79	menthol	menthol	NOUN
ctmj-149	43	80	,	,	PUNCT
ctmj-149	43	81	respectively	respectively	ADV
ctmj-149	43	82	)	)	PUNCT
ctmj-149	43	83	,	,	PUNCT
ctmj-149	43	84	and	and	CCONJ
ctmj-149	43	85	ppm	ppm	ADJ
ctmj-149	43	86	group	group	NOUN
ctmj-149	43	87	(	(	PUNCT
ctmj-149	43	88	0.1	0.1	NUM
ctmj-149	43	89	mg	mg	NUM
ctmj-149	43	90	/	/	SYM
ctmj-149	43	91	ml	ml	NOUN
ctmj-149	43	92	puerarin	puerarin	NOUN
ctmj-149	43	93	,	,	PUNCT
ctmj-149	43	94	0.04	0.04	NUM
ctmj-149	43	95	mg	mg	NUM
ctmj-149	43	96	/	/	SYM
ctmj-149	43	97	ml	ml	NOUN
ctmj-149	43	98	paeoniflorin	paeoniflorin	NOUN
ctmj-149	43	99	,	,	PUNCT
ctmj-149	43	100	and	and	CCONJ
ctmj-149	43	101	0.05	0.05	NUM
ctmj-149	43	102	mg	mg	NUM
ctmj-149	43	103	/	/	SYM
ctmj-149	43	104	ml	ml	NOUN
ctmj-149	43	105	menthol	menthol	NOUN
ctmj-149	43	106	,	,	PUNCT
ctmj-149	43	107	respectively	respectively	ADV
ctmj-149	43	108	)	)	PUNCT
ctmj-149	43	109	groups	group	NOUN
ctmj-149	43	110	.	.	PUNCT
ctmj-149	44	1	immunofluorescence	immunofluorescence	NOUN
ctmj-149	44	2	microscopy	microscopy	NOUN
ctmj-149	44	3	for	for	ADP
ctmj-149	44	4	immunocytochemical	immunocytochemical	ADJ
ctmj-149	44	5	analysis	analysis	NOUN
ctmj-149	44	6	,	,	PUNCT
ctmj-149	44	7	the	the	DET
ctmj-149	44	8	cells	cell	NOUN
ctmj-149	44	9	were	be	AUX
ctmj-149	44	10	seeded	seed	VERB
ctmj-149	44	11	on	on	ADP
ctmj-149	44	12	15	15	NUM
ctmj-149	44	13	mm	mm	NOUN
ctmj-149	44	14	coated	coated	ADJ
ctmj-149	44	15	glass	glass	NOUN
ctmj-149	44	16	coverslips	coverslip	NOUN
ctmj-149	44	17	.	.	PUNCT
ctmj-149	45	1	when	when	SCONJ
ctmj-149	45	2	cell	cell	NOUN
ctmj-149	45	3	fusion	fusion	NOUN
ctmj-149	45	4	attained	attain	VERB
ctmj-149	45	5	approximately	approximately	ADV
ctmj-149	45	6	80e90	80e90	NUM
ctmj-149	45	7	%	%	NOUN
ctmj-149	45	8	,	,	PUNCT
ctmj-149	45	9	the	the	DET
ctmj-149	45	10	regular	regular	ADJ
ctmj-149	45	11	media	medium	NOUN
ctmj-149	45	12	were	be	AUX
ctmj-149	45	13	replaced	replace	VERB
ctmj-149	45	14	with	with	ADP
ctmj-149	45	15	media	medium	NOUN
ctmj-149	45	16	containing	contain	VERB
ctmj-149	45	17	the	the	DET
ctmj-149	45	18	various	various	ADJ
ctmj-149	45	19	compounds	compound	NOUN
ctmj-149	45	20	(	(	PUNCT
ctmj-149	45	21	puerarin	puerarin	NOUN
ctmj-149	45	22	,	,	PUNCT
ctmj-149	45	23	paeoniflorin	paeoniflorin	NOUN
ctmj-149	45	24	,	,	PUNCT
ctmj-149	45	25	or	or	CCONJ
ctmj-149	45	26	menthol	menthol	NOUN
ctmj-149	45	27	at	at	ADP
ctmj-149	45	28	0.1	0.1	NUM
ctmj-149	45	29	mg	mg	PROPN
ctmj-149	45	30	/	/	SYM
ctmj-149	45	31	ml	ml	NOUN
ctmj-149	45	32	,	,	PUNCT
ctmj-149	45	33	0.04	0.04	NUM
ctmj-149	45	34	mg	mg	NUM
ctmj-149	45	35	/	/	SYM
ctmj-149	45	36	ml	ml	NOUN
ctmj-149	45	37	and	and	CCONJ
ctmj-149	45	38	the	the	DET
ctmj-149	45	39	previously	previously	ADV
ctmj-149	45	40	described	describe	VERB
ctmj-149	45	41	drug	drug	NOUN
ctmj-149	45	42	combinations	combination	NOUN
ctmj-149	45	43	was	be	AUX
ctmj-149	45	44	measured	measure	VERB
ctmj-149	45	45	at	at	ADP
ctmj-149	45	46	30	30	NUM
ctmj-149	45	47	,	,	PUNCT
ctmj-149	45	48	60	60	NUM
ctmj-149	45	49	,	,	PUNCT
ctmj-149	45	50	90,120,150	90,120,150	NUM
ctmj-149	45	51	,	,	PUNCT
ctmj-149	45	52	and	and	CCONJ
ctmj-149	46	1	180	180	NUM
ctmj-149	46	2	min	min	NOUN
ctmj-149	46	3	.	.	PROPN
ctmj-149	46	4	teer	teer	PROPN
ctmj-149	46	5	was	be	AUX
ctmj-149	46	6	measured	measure	VERB
ctmj-149	46	7	immediately	immediately	ADV
ctmj-149	46	8	following	follow	VERB
ctmj-149	46	9	drug	drug	NOUN
ctmj-149	46	10	treatment	treatment	NOUN
ctmj-149	46	11	(	(	PUNCT
ctmj-149	46	12	0	0	NUM
ctmj-149	46	13	min	min	NOUN
ctmj-149	46	14	)	)	PUNCT
ctmj-149	46	15	and	and	CCONJ
ctmj-149	46	16	was	be	AUX
ctmj-149	46	17	set	set	VERB
ctmj-149	46	18	to	to	ADP
ctmj-149	46	19	100	100	NUM
ctmj-149	46	20	%	%	NOUN
ctmj-149	46	21	,	,	PUNCT
ctmj-149	46	22	with	with	ADP
ctmj-149	46	23	all	all	DET
ctmj-149	46	24	the	the	DET
ctmj-149	46	25	other	other	ADJ
ctmj-149	46	26	values	value	NOUN
ctmj-149	46	27	calculated	calculate	VERB
ctmj-149	46	28	and	and	CCONJ
ctmj-149	46	29	expressed	express	VERB
ctmj-149	46	30	relative	relative	ADJ
ctmj-149	46	31	to	to	ADP
ctmj-149	46	32	this	this	DET
ctmj-149	46	33	value	value	NOUN
ctmj-149	46	34	.	.	PUNCT
ctmj-149	47	1	finally	finally	ADV
ctmj-149	47	2	,	,	PUNCT
ctmj-149	47	3	teer	teer	PROPN
ctmj-149	47	4	at	at	ADP
ctmj-149	47	5	each	each	DET
ctmj-149	47	6	time	time	NOUN
ctmj-149	47	7	point	point	NOUN
ctmj-149	47	8	was	be	AUX
ctmj-149	47	9	compared	compare	VERB
ctmj-149	47	10	to	to	ADP
ctmj-149	47	11	that	that	PRON
ctmj-149	47	12	of	of	ADP
ctmj-149	47	13	the	the	DET
ctmj-149	47	14	control	control	NOUN
ctmj-149	47	15	group	group	NOUN
ctmj-149	47	16	and	and	CCONJ
ctmj-149	47	17	statistically	statistically	ADV
ctmj-149	47	18	analyzed	analyze	VERB
ctmj-149	47	19	.	.	PUNCT
ctmj-149	48	1	data	datum	NOUN
ctmj-149	48	2	analysis	analysis	NOUN
ctmj-149	48	3	and	and	CCONJ
ctmj-149	48	4	statistics	statistic	NOUN
ctmj-149	48	5	immunofluorescence	immunofluorescence	NOUN
ctmj-149	48	6	images	image	NOUN
ctmj-149	48	7	were	be	AUX
ctmj-149	48	8	analyzed	analyze	VERB
ctmj-149	48	9	semi	semi	ADV
ctmj-149	48	10	quantitatively	quantitatively	ADV
ctmj-149	48	11	using	use	VERB
ctmj-149	48	12	imagej	imagej	ADJ
ctmj-149	48	13	software	software	NOUN
ctmj-149	48	14	based	base	VERB
ctmj-149	48	15	on	on	ADP
ctmj-149	48	16	the	the	DET
ctmj-149	48	17	following	follow	VERB
ctmj-149	48	18	equations	equation	NOUN
ctmj-149	48	19	:	:	PUNCT
ctmj-149	48	20	intden	intden	PROPN
ctmj-149	48	21	z	z	PROPN
ctmj-149	48	22	area	area	NOUN
ctmj-149	48	23	(	(	PUNCT
ctmj-149	48	24	1	1	NUM
ctmj-149	48	25	)	)	PUNCT
ctmj-149	48	26	where	where	SCONJ
ctmj-149	48	27	intden	intden	PROPN
ctmj-149	48	28	is	be	AUX
ctmj-149	48	29	the	the	DET
ctmj-149	48	30	integrated	integrate	VERB
ctmj-149	48	31	optical	optical	ADJ
ctmj-149	48	32	density	density	NOUN
ctmj-149	48	33	(	(	PUNCT
ctmj-149	48	34	iod	iod	NOUN
ctmj-149	48	35	)	)	PUNCT
ctmj-149	48	36	of	of	ADP
ctmj-149	48	37	the	the	DET
ctmj-149	48	38	image	image	NOUN
ctmj-149	48	39	,	,	PUNCT
ctmj-149	48	40	area	area	NOUN
ctmj-149	48	41	is	be	AUX
ctmj-149	48	42	the	the	DET
ctmj-149	48	43	region	region	NOUN
ctmj-149	48	44	of	of	ADP
ctmj-149	48	45	fluorescence	fluorescence	NOUN
ctmj-149	48	46	in	in	ADP
ctmj-149	48	47	the	the	DET
ctmj-149	48	48	image	image	NOUN
ctmj-149	48	49	,	,	PUNCT
ctmj-149	48	50	and	and	CCONJ
ctmj-149	48	51	aod	aod	PROPN
ctmj-149	48	52	is	be	AUX
ctmj-149	48	53	the	the	DET
ctmj-149	48	54	average	average	ADJ
ctmj-149	48	55	optical	optical	ADJ
ctmj-149	48	56	density	density	NOUN
ctmj-149	48	57	.	.	PUNCT
ctmj-149	49	1	percentage	percentage	NOUN
ctmj-149	49	2	aod	aod	PROPN
ctmj-149	49	3	(	(	PUNCT
ctmj-149	49	4	%	%	NOUN
ctmj-149	49	5	)	)	PUNCT
ctmj-149	49	6	of	of	ADP
ctmj-149	49	7	the	the	DET
ctmj-149	49	8	tj	tj	NOUN
ctmj-149	49	9	proteins	protein	NOUN
ctmj-149	49	10	was	be	AUX
ctmj-149	49	11	calculated	calculate	VERB
ctmj-149	49	12	using	use	VERB
ctmj-149	49	13	the	the	DET
ctmj-149	49	14	following	follow	VERB
ctmj-149	49	15	equation	equation	NOUN
ctmj-149	49	16	:	:	PUNCT
ctmj-149	49	17	aodsample	aodsample	NOUN
ctmj-149	49	18	0.05	0.05	NUM
ctmj-149	49	19	mg	mg	PROPN
ctmj-149	49	20	/	/	SYM
ctmj-149	49	21	ml	ml	NOUN
ctmj-149	49	22	,	,	PUNCT
ctmj-149	49	23	respectively	respectively	ADV
ctmj-149	49	24	)	)	PUNCT
ctmj-149	49	25	and	and	CCONJ
ctmj-149	49	26	the	the	DET
ctmj-149	49	27	cells	cell	NOUN
ctmj-149	49	28	were	be	AUX
ctmj-149	49	29	further	far	ADV
ctmj-149	49	30	cultured	cultured	ADJ
ctmj-149	49	31	for	for	ADP
ctmj-149	49	32	3	3	NUM
ctmj-149	49	33	h	h	NOUN
ctmj-149	49	34	,	,	PUNCT
ctmj-149	49	35	and	and	CCONJ
ctmj-149	49	36	then	then	ADV
ctmj-149	49	37	fixed	fix	VERB
ctmj-149	49	38	with	with	ADP
ctmj-149	49	39	cold	cold	ADJ
ctmj-149	49	40	4	4	NUM
ctmj-149	49	41	%	%	NOUN
ctmj-149	49	42	paraelative	paraelative	ADJ
ctmj-149	49	43	aod	aod	PROPN
ctmj-149	49	44	(	(	PUNCT
ctmj-149	49	45	%	%	NOUN
ctmj-149	49	46	)	)	PUNCT
ctmj-149	49	47	z	z	NOUN
ctmj-149	49	48	formaldehyde	formaldehyde	NOUN
ctmj-149	49	49	for	for	ADP
ctmj-149	49	50	30	30	NUM
ctmj-149	49	51	min	min	NOUN
ctmj-149	49	52	.	.	NOUN
ctmj-149	49	53	after	after	ADP
ctmj-149	49	54	washing	wash	VERB
ctmj-149	49	55	thrice	thrice	NOUN
ctmj-149	49	56	for	for	ADP
ctmj-149	49	57	5	5	NUM
ctmj-149	49	58	min	min	NOUN
ctmj-149	49	59	each	each	PRON
ctmj-149	49	60	with	with	ADP
ctmj-149	49	61	phosphate	phosphate	NOUN
ctmj-149	49	62	-	-	PUNCT
ctmj-149	49	63	buffered	buffer	VERB
ctmj-149	49	64	saline	saline	NOUN
ctmj-149	49	65	(	(	PUNCT
ctmj-149	49	66	pbs	pbs	PROPN
ctmj-149	49	67	)	)	PUNCT
ctmj-149	49	68	,	,	PUNCT
ctmj-149	49	69	the	the	DET
ctmj-149	49	70	cov	cov	NOUN
ctmj-149	49	71	erslips	erslip	NOUN
ctmj-149	49	72	were	be	AUX
ctmj-149	49	73	incubated	incubate	VERB
ctmj-149	49	74	for	for	ADP
ctmj-149	49	75	1	1	NUM
ctmj-149	49	76	h	h	NOUN
ctmj-149	49	77	with	with	ADP
ctmj-149	49	78	goat	goat	PROPN
ctmj-149	49	79	serum	serum	PROPN
ctmj-149	49	80	as	as	ADP
ctmj-149	49	81	the	the	DET
ctmj-149	49	82	blocking	blocking	NOUN
ctmj-149	49	83	buffer	buffer	NOUN
ctmj-149	49	84	.	.	PUNCT
ctmj-149	50	1	then	then	ADV
ctmj-149	50	2	,	,	PUNCT
ctmj-149	50	3	after	after	ADP
ctmj-149	50	4	rinsing	rinse	VERB
ctmj-149	50	5	with	with	ADP
ctmj-149	50	6	pbs	pbs	PROPN
ctmj-149	50	7	thrice	thrice	PROPN
ctmj-149	50	8	,	,	PUNCT
ctmj-149	50	9	some	some	DET
ctmj-149	50	10	coverslips	coverslip	NOUN
ctmj-149	50	11	were	be	AUX
ctmj-149	50	12	incubated	incubate	VERB
ctmj-149	50	13	with	with	ADP
ctmj-149	50	14	polyclonal	polyclonal	ADJ
ctmj-149	50	15	anti	anti	ADJ
ctmj-149	50	16	-	-	ADJ
ctmj-149	50	17	occludin	occludin	ADJ
ctmj-149	50	18	or	or	CCONJ
ctmj-149	50	19	monoclonal	monoclonal	NOUN
ctmj-149	50	20	anti	anti	ADJ
ctmj-149	50	21	-	-	ADJ
ctmj-149	50	22	claudin-1primary	claudin-1primary	ADJ
ctmj-149	50	23	antibodies	antibody	NOUN
ctmj-149	50	24	(	(	PUNCT
ctmj-149	50	25	1:100	1:100	NUM
ctmj-149	50	26	,	,	PUNCT
ctmj-149	50	27	each	each	PRON
ctmj-149	50	28	)	)	PUNCT
ctmj-149	50	29	at	at	ADP
ctmj-149	50	30	4	4	NUM
ctmj-149	50	31	◦	◦	NOUN
ctmj-149	50	32	covernight	covernight	NOUN
ctmj-149	50	33	followed	follow	VERB
ctmj-149	50	34	by	by	ADP
ctmj-149	50	35	incubation	incubation	NOUN
ctmj-149	50	36	with	with	ADP
ctmj-149	50	37	tritc	tritc	PROPN
ctmj-149	50	38	conjugated	conjugate	VERB
ctmj-149	50	39	anti	anti	ADJ
ctmj-149	50	40	-	-	ADJ
ctmj-149	50	41	rabbit	rabbit	ADJ
ctmj-149	50	42	igg	igg	PROPN
ctmj-149	50	43	or	or	CCONJ
ctmj-149	50	44	fitc	fitc	NOUN
ctmj-149	50	45	-	-	PUNCT
ctmj-149	50	46	conjugated	conjugate	VERB
ctmj-149	50	47	anti	anti	ADJ
ctmj-149	50	48	-	-	ADJ
ctmj-149	50	49	mouse	mouse	ADJ
ctmj-149	50	50	igg	igg	PROPN
ctmj-149	50	51	.	.	PUNCT
ctmj-149	51	1	other	other	ADJ
ctmj-149	51	2	cells	cell	NOUN
ctmj-149	51	3	were	be	AUX
ctmj-149	51	4	only	only	ADV
ctmj-149	51	5	stained	stain	VERB
ctmj-149	51	6	with	with	ADP
ctmj-149	51	7	acti	acti	NOUN
ctmj-149	51	8	-	-	PUNCT
ctmj-149	51	9	stain	stain	NOUN
ctmj-149	51	10	488	488	NUM
ctmj-149	51	11	phalloidin	phalloidin	NOUN
ctmj-149	51	12	stain	stain	NOUN
ctmj-149	51	13	(	(	PUNCT
ctmj-149	51	14	1:150	1:150	NUM
ctmj-149	51	15	)	)	PUNCT
ctmj-149	51	16	at	at	ADP
ctmj-149	51	17	25	25	NUM
ctmj-149	51	18	◦	◦	NOUN
ctmj-149	51	19	c	c	NOUN
ctmj-149	51	20	for	for	ADP
ctmj-149	51	21	30	30	NUM
ctmj-149	51	22	min	min	NOUN
ctmj-149	51	23	.	.	PROPN
ctmj-149	51	24	cell	cell	NOUN
ctmj-149	51	25	nuclei	nucleus	NOUN
ctmj-149	51	26	were	be	AUX
ctmj-149	51	27	counterstained	counterstaine	VERB
ctmj-149	51	28	with	with	ADP
ctmj-149	51	29	4	4	NUM
ctmj-149	51	30	'	'	NUM
ctmj-149	51	31	,	,	PUNCT
ctmj-149	51	32	6	6	NUM
ctmj-149	51	33	-	-	PUNCT
ctmj-149	51	34	diamidino-2	diamidino-2	NOUN
ctmj-149	51	35	-	-	PUNCT
ctmj-149	51	36	phenylindole	phenylindole	NOUN
ctmj-149	51	37	(	(	PUNCT
ctmj-149	51	38	dapi	dapi	PROPN
ctmj-149	51	39	,	,	PUNCT
ctmj-149	51	40	beijing	beijing	PROPN
ctmj-149	51	41	solarbio	solarbio	NOUN
ctmj-149	51	42	science	science	NOUN
ctmj-149	51	43	and	and	CCONJ
ctmj-149	51	44	technology	technology	NOUN
ctmj-149	51	45	,	,	PUNCT
ctmj-149	51	46	beijing	beijing	PROPN
ctmj-149	51	47	,	,	PUNCT
ctmj-149	51	48	china	china	PROPN
ctmj-149	51	49	)	)	PUNCT
ctmj-149	51	50	.	.	PUNCT
ctmj-149	52	1	the	the	DET
ctmj-149	52	2	cells	cell	NOUN
ctmj-149	52	3	were	be	AUX
ctmj-149	52	4	visualized	visualize	VERB
ctmj-149	52	5	using	use	VERB
ctmj-149	52	6	an	an	DET
ctmj-149	52	7	inverted	inverted	ADJ
ctmj-149	52	8	fluorescence	fluorescence	NOUN
ctmj-149	52	9	microscope	microscope	NOUN
ctmj-149	52	10	equipped	equip	VERB
ctmj-149	52	11	with	with	ADP
ctmj-149	52	12	appropriate	appropriate	ADJ
ctmj-149	52	13	filters	filter	NOUN
ctmj-149	52	14	(	(	PUNCT
ctmj-149	52	15	olympus	olympus	PROPN
ctmj-149	52	16	,	,	PUNCT
ctmj-149	52	17	tokyo	tokyo	PROPN
ctmj-149	52	18	,	,	PUNCT
ctmj-149	52	19	japan	japan	PROPN
ctmj-149	52	20	)	)	PUNCT
ctmj-149	52	21	.	.	PUNCT
ctmj-149	53	1	images	image	NOUN
ctmj-149	53	2	were	be	AUX
ctmj-149	53	3	acquired	acquire	VERB
ctmj-149	53	4	using	use	VERB
ctmj-149	53	5	a	a	DET
ctmj-149	53	6	laser	laser	NOUN
ctmj-149	53	7	scanning	scan	VERB
ctmj-149	53	8	confocal	confocal	ADJ
ctmj-149	53	9	microscope	microscope	NOUN
ctmj-149	53	10	and	and	CCONJ
ctmj-149	53	11	accompanying	accompany	VERB
ctmj-149	53	12	analysis	analysis	NOUN
ctmj-149	53	13	software	software	NOUN
ctmj-149	53	14	.	.	PUNCT
ctmj-149	54	1	fluorescence	fluorescence	NOUN
ctmj-149	54	2	intensity	intensity	NOUN
ctmj-149	54	3	of	of	ADP
ctmj-149	54	4	the	the	DET
ctmj-149	54	5	images	image	NOUN
ctmj-149	54	6	was	be	AUX
ctmj-149	54	7	measured	measure	VERB
ctmj-149	54	8	using	use	VERB
ctmj-149	54	9	imagej	imagej	ADJ
ctmj-149	54	10	software	software	NOUN
ctmj-149	54	11	(	(	PUNCT
ctmj-149	54	12	national	national	ADJ
ctmj-149	54	13	institutes	institutes	PROPN
ctmj-149	54	14	of	of	ADP
ctmj-149	54	15	health	health	NOUN
ctmj-149	54	16	,	,	PUNCT
ctmj-149	54	17	bethesda	bethesda	PROPN
ctmj-149	54	18	,	,	PUNCT
ctmj-149	54	19	md	md	PROPN
ctmj-149	54	20	,	,	PUNCT
ctmj-149	54	21	usa	usa	PROPN
ctmj-149	54	22	)	)	PUNCT
ctmj-149	54	23	.	.	PUNCT
ctmj-149	55	1	measurement	measurement	NOUN
ctmj-149	55	2	of	of	ADP
ctmj-149	55	3	transepithelial	transepithelial	ADJ
ctmj-149	55	4	electrical	electrical	ADJ
ctmj-149	55	5	resistance	resistance	NOUN
ctmj-149	55	6	to	to	PART
ctmj-149	55	7	investigate	investigate	VERB
ctmj-149	55	8	changes	change	NOUN
ctmj-149	55	9	in	in	ADP
ctmj-149	55	10	the	the	DET
ctmj-149	55	11	tjs	tjs	NOUN
ctmj-149	55	12	barrier	barrier	NOUN
ctmj-149	55	13	function	function	NOUN
ctmj-149	55	14	of	of	ADP
ctmj-149	55	15	the	the	DET
ctmj-149	55	16	mdck	mdck	PROPN
ctmj-149	55	17	and	and	CCONJ
ctmj-149	55	18	mdck	mdck	PROPN
ctmj-149	55	19	-	-	PUNCT
ctmj-149	55	20	mdr1	mdr1	PROPN
ctmj-149	55	21	cells	cell	NOUN
ctmj-149	55	22	,	,	PUNCT
ctmj-149	55	23	transepithelial	transepithelial	ADJ
ctmj-149	55	24	electrical	electrical	ADJ
ctmj-149	55	25	resistance	resistance	NOUN
ctmj-149	55	26	(	(	PUNCT
ctmj-149	55	27	teer	teer	NOUN
ctmj-149	55	28	)	)	PUNCT
ctmj-149	55	29	of	of	ADP
ctmj-149	55	30	the	the	DET
ctmj-149	55	31	monolayers	monolayer	NOUN
ctmj-149	55	32	was	be	AUX
ctmj-149	55	33	detected	detect	VERB
ctmj-149	55	34	using	use	VERB
ctmj-149	55	35	the	the	DET
ctmj-149	55	36	evom	evom	NOUN
ctmj-149	55	37	epithelial	epithelial	ADJ
ctmj-149	55	38	voltohmmeter	voltohmmeter	NOUN
ctmj-149	55	39	(	(	PUNCT
ctmj-149	55	40	emd	emd	PROPN
ctmj-149	55	41	millipore	millipore	PROPN
ctmj-149	55	42	,	,	PUNCT
ctmj-149	55	43	billerica	billerica	PROPN
ctmj-149	55	44	,	,	PUNCT
ctmj-149	55	45	ma	ma	PROPN
ctmj-149	55	46	,	,	PUNCT
ctmj-149	55	47	usa	usa	PROPN
ctmj-149	55	48	)	)	PUNCT
ctmj-149	55	49	.	.	PUNCT
ctmj-149	56	1	both	both	DET
ctmj-149	56	2	cell	cell	NOUN
ctmj-149	56	3	types	type	NOUN
ctmj-149	56	4	were	be	AUX
ctmj-149	56	5	cultured	cultured	ADJ
ctmj-149	56	6	separately	separately	ADV
ctmj-149	56	7	on0.4	on0.4	NUM
ctmj-149	56	8	mm	mm	INTJ
ctmj-149	56	9	pore	pore	ADJ
ctmj-149	56	10	size	size	NOUN
ctmj-149	56	11	filters	filter	NOUN
ctmj-149	56	12	of	of	ADP
ctmj-149	56	13	12	12	NUM
ctmj-149	56	14	mm	mm	NOUN
ctmj-149	56	15	transwellsand	transwellsand	NOUN
ctmj-149	56	16	grown	grow	VERB
ctmj-149	56	17	to	to	ADP
ctmj-149	56	18	confluence	confluence	NOUN
ctmj-149	56	19	.	.	PUNCT
ctmj-149	57	1	then	then	ADV
ctmj-149	57	2	,	,	PUNCT
ctmj-149	57	3	0.5	0.5	NUM
ctmj-149	57	4	ml	ml	NOUN
ctmj-149	57	5	and	and	CCONJ
ctmj-149	57	6	1.5	1.5	NUM
ctmj-149	57	7	ml	ml	NOUN
ctmj-149	57	8	of	of	ADP
ctmj-149	57	9	drug	drug	NOUN
ctmj-149	57	10	solution	solution	NOUN
ctmj-149	57	11	and	and	CCONJ
ctmj-149	57	12	hank	hank	PROPN
ctmj-149	57	13	’s	’s	PART
ctmj-149	57	14	basic	basic	ADJ
ctmj-149	57	15	salt	salt	NOUN
ctmj-149	57	16	solution	solution	NOUN
ctmj-149	57	17	(	(	PUNCT
ctmj-149	57	18	hbss	hbss	NOUN
ctmj-149	57	19	)	)	PUNCT
ctmj-149	57	20	were	be	AUX
ctmj-149	57	21	added	add	VERB
ctmj-149	57	22	to	to	ADP
ctmj-149	57	23	the	the	DET
ctmj-149	57	24	apical	apical	ADJ
ctmj-149	57	25	(	(	PUNCT
ctmj-149	57	26	a	a	NOUN
ctmj-149	57	27	)	)	PUNCT
ctmj-149	57	28	side	side	NOUN
ctmj-149	57	29	and	and	CCONJ
ctmj-149	57	30	basolateral	basolateral	ADJ
ctmj-149	57	31	(	(	PUNCT
ctmj-149	57	32	b	b	NOUN
ctmj-149	57	33	)	)	PUNCT
ctmj-149	57	34	side	side	NOUN
ctmj-149	57	35	,	,	PUNCT
ctmj-149	57	36	respectively	respectively	ADV
ctmj-149	57	37	to	to	PART
ctmj-149	57	38	simulate	simulate	VERB
ctmj-149	57	39	a	a	DET
ctmj-149	57	40	/	/	SYM
ctmj-149	57	41	b	b	NOUN
ctmj-149	57	42	transport	transport	NOUN
ctmj-149	57	43	while	while	SCONJ
ctmj-149	57	44	in	in	ADP
ctmj-149	57	45	a	a	DET
ctmj-149	57	46	parallel	parallel	ADJ
ctmj-149	57	47	experiment	experiment	NOUN
ctmj-149	57	48	,	,	PUNCT
ctmj-149	57	49	b	b	X
ctmj-149	57	50	/	/	SYM
ctmj-149	57	51	a	a	DET
ctmj-149	57	52	transport	transport	NOUN
ctmj-149	57	53	was	be	AUX
ctmj-149	57	54	simulated	simulate	VERB
ctmj-149	57	55	by	by	ADP
ctmj-149	57	56	reversing	reverse	VERB
ctmj-149	57	57	the	the	DET
ctmj-149	57	58	order	order	NOUN
ctmj-149	57	59	of	of	ADP
ctmj-149	57	60	the	the	DET
ctmj-149	57	61	drug	drug	NOUN
ctmj-149	57	62	solution	solution	NOUN
ctmj-149	57	63	and	and	CCONJ
ctmj-149	57	64	hbss	hbss	NOUN
ctmj-149	57	65	.	.	PUNCT
ctmj-149	58	1	teer	teer	NOUN
ctmj-149	58	2	of	of	ADP
ctmj-149	58	3	untreated	untreated	ADJ
ctmj-149	58	4	or	or	CCONJ
ctmj-149	58	5	puerarin-	puerarin-	ADV
ctmj-149	58	6	,	,	PUNCT
ctmj-149	58	7	paeo	paeo	NOUN
ctmj-149	58	8	niflorin-	niflorin-	X
ctmj-149	58	9	,	,	PUNCT
ctmj-149	58	10	and	and	CCONJ
ctmj-149	58	11	menthol	menthol	NOUN
ctmj-149	58	12	-	-	PUNCT
ctmj-149	58	13	treated	treat	VERB
ctmj-149	58	14	cells	cell	NOUN
ctmj-149	58	15	or	or	CCONJ
ctmj-149	58	16	those	those	PRON
ctmj-149	58	17	treated	treat	VERB
ctmj-149	58	18	with	with	ADP
ctmj-149	58	19	where	where	SCONJ
ctmj-149	58	20	aodsample	aodsample	NOUN
ctmj-149	58	21	and	and	CCONJ
ctmj-149	58	22	aodcontrol	aodcontrol	NOUN
ctmj-149	58	23	are	be	AUX
ctmj-149	58	24	the	the	DET
ctmj-149	58	25	aods	aod	NOUN
ctmj-149	58	26	of	of	ADP
ctmj-149	58	27	the	the	DET
ctmj-149	58	28	sample	sample	NOUN
ctmj-149	58	29	and	and	CCONJ
ctmj-149	58	30	control	control	NOUN
ctmj-149	58	31	,	,	PUNCT
ctmj-149	58	32	respectively	respectively	ADV
ctmj-149	58	33	.	.	PUNCT
ctmj-149	59	1	percentage	percentage	NOUN
ctmj-149	59	2	teer	teer	PROPN
ctmj-149	59	3	was	be	AUX
ctmj-149	59	4	calculated	calculate	VERB
ctmj-149	59	5	using	use	VERB
ctmj-149	59	6	the	the	DET
ctmj-149	59	7	following	follow	VERB
ctmj-149	59	8	equation	equation	NOUN
ctmj-149	59	9	:	:	PUNCT
ctmj-149	59	10	relative	relative	ADJ
ctmj-149	59	11	teer	teer	NOUN
ctmj-149	59	12	(	(	PUNCT
ctmj-149	59	13	%	%	NOUN
ctmj-149	59	14	)	)	PUNCT
ctmj-149	59	15	z	z	NOUN
ctmj-149	59	16	teert	teert	PROPN
ctmj-149	59	17	×	×	NOUN
ctmj-149	59	18	100	100	NUM
ctmj-149	59	19	(	(	PUNCT
ctmj-149	59	20	3	3	NUM
ctmj-149	59	21	)	)	PUNCT
ctmj-149	59	22	teert0	teert0	NOUN
ctmj-149	59	23	where	where	SCONJ
ctmj-149	59	24	teert	teert	NOUN
ctmj-149	59	25	is	be	AUX
ctmj-149	59	26	the	the	DET
ctmj-149	59	27	teer	teer	NOUN
ctmj-149	59	28	value	value	NOUN
ctmj-149	59	29	at	at	ADP
ctmj-149	59	30	different	different	ADJ
ctmj-149	59	31	times	time	NOUN
ctmj-149	59	32	and	and	CCONJ
ctmj-149	59	33	teert0	teert0	PROPN
ctmj-149	59	34	is	be	AUX
ctmj-149	59	35	the	the	DET
ctmj-149	59	36	initial	initial	ADJ
ctmj-149	59	37	teer	teer	NOUN
ctmj-149	59	38	value	value	NOUN
ctmj-149	59	39	before	before	SCONJ
ctmj-149	59	40	the	the	DET
ctmj-149	59	41	experiment	experiment	NOUN
ctmj-149	59	42	was	be	AUX
ctmj-149	59	43	performed	perform	VERB
ctmj-149	59	44	.	.	PUNCT
ctmj-149	60	1	results	result	NOUN
ctmj-149	60	2	are	be	AUX
ctmj-149	60	3	presented	present	VERB
ctmj-149	60	4	as	as	ADP
ctmj-149	60	5	means	mean	NOUN
ctmj-149	60	6	(	(	PUNCT
ctmj-149	60	7	sd	sd	NOUN
ctmj-149	60	8	)	)	PUNCT
ctmj-149	60	9	of	of	ADP
ctmj-149	60	10	3	3	NUM
ctmj-149	60	11	separate	separate	ADJ
ctmj-149	60	12	parallel	parallel	ADJ
ctmj-149	60	13	experiments	experiment	NOUN
ctmj-149	60	14	.	.	PUNCT
ctmj-149	61	1	data	datum	NOUN
ctmj-149	61	2	were	be	AUX
ctmj-149	61	3	analyzed	analyze	VERB
ctmj-149	61	4	using	use	VERB
ctmj-149	61	5	a	a	DET
ctmj-149	61	6	oneway	oneway	ADJ
ctmj-149	61	7	analysis	analysis	NOUN
ctmj-149	61	8	of	of	ADP
ctmj-149	61	9	variance	variance	NOUN
ctmj-149	61	10	(	(	PUNCT
ctmj-149	61	11	anova	anova	PROPN
ctmj-149	61	12	)	)	PUNCT
ctmj-149	61	13	,	,	PUNCT
ctmj-149	61	14	followed	follow	VERB
ctmj-149	61	15	by	by	ADP
ctmj-149	61	16	dunnett	dunnett	PROPN
ctmj-149	61	17	’s	’s	PART
ctmj-149	61	18	test	test	NOUN
ctmj-149	61	19	to	to	PART
ctmj-149	61	20	determine	determine	VERB
ctmj-149	61	21	the	the	DET
ctmj-149	61	22	difference	difference	NOUN
ctmj-149	61	23	between	between	ADP
ctmj-149	61	24	multiple	multiple	ADJ
ctmj-149	61	25	groups	group	NOUN
ctmj-149	61	26	compared	compare	VERB
ctmj-149	61	27	to	to	ADP
ctmj-149	61	28	the	the	DET
ctmj-149	61	29	control	control	NOUN
ctmj-149	61	30	group	group	NOUN
ctmj-149	61	31	using	use	VERB
ctmj-149	61	32	spss	spss	PROPN
ctmj-149	61	33	version	version	NOUN
ctmj-149	61	34	17.0	17.0	NUM
ctmj-149	61	35	software	software	NOUN
ctmj-149	61	36	.	.	PUNCT
ctmj-149	62	1	a	a	DET
ctmj-149	62	2	p	p	X
ctmj-149	62	3	<	<	X
ctmj-149	62	4	.05	.05	NUM
ctmj-149	62	5	was	be	AUX
ctmj-149	62	6	considered	consider	VERB
ctmj-149	62	7	statistically	statistically	ADV
ctmj-149	62	8	significant	significant	ADJ
ctmj-149	62	9	.	.	PUNCT
ctmj-149	63	1	results	result	NOUN
ctmj-149	63	2	effect	effect	NOUN
ctmj-149	63	3	of	of	ADP
ctmj-149	63	4	compounds	compound	NOUN
ctmj-149	63	5	on	on	ADP
ctmj-149	63	6	expression	expression	NOUN
ctmj-149	63	7	of	of	ADP
ctmj-149	63	8	tj	tj	NOUN
ctmj-149	63	9	proteins	protein	NOUN
ctmj-149	63	10	to	to	PART
ctmj-149	63	11	determine	determine	VERB
ctmj-149	63	12	the	the	DET
ctmj-149	63	13	effects	effect	NOUN
ctmj-149	63	14	of	of	ADP
ctmj-149	63	15	the	the	DET
ctmj-149	63	16	compounds	compound	NOUN
ctmj-149	63	17	on	on	ADP
ctmj-149	63	18	tj	tj	NOUN
ctmj-149	63	19	proteins	protein	NOUN
ctmj-149	63	20	of	of	ADP
ctmj-149	63	21	the	the	DET
ctmj-149	63	22	mdck	mdck	PROPN
ctmj-149	63	23	and	and	CCONJ
ctmj-149	63	24	mdck	mdck	PROPN
ctmj-149	63	25	-	-	PUNCT
ctmj-149	63	26	mdr1	mdr1	PROPN
ctmj-149	63	27	cells	cell	NOUN
ctmj-149	63	28	,	,	PUNCT
ctmj-149	63	29	we	we	PRON
ctmj-149	63	30	immunohistochemically	immunohistochemically	ADV
ctmj-149	63	31	analyzed	analyze	VERB
ctmj-149	63	32	occludin	occludin	PROPN
ctmj-149	63	33	,	,	PUNCT
ctmj-149	63	34	claudin-1	claudin-1	PROPN
ctmj-149	63	35	,	,	PUNCT
ctmj-149	63	36	and	and	CCONJ
ctmj-149	63	37	f	f	X
ctmj-149	63	38	-	-	PUNCT
ctmj-149	63	39	actin	actin	NOUN
ctmj-149	63	40	using	use	VERB
ctmj-149	63	41	laser	laser	NOUN
ctmj-149	63	42	scanning	scan	VERB
ctmj-149	63	43	confocal	confocal	ADJ
ctmj-149	63	44	microscopy	microscopy	NOUN
ctmj-149	63	45	(	(	PUNCT
ctmj-149	63	46	fig	fig	NOUN
ctmj-149	63	47	.	.	PUNCT
ctmj-149	64	1	1	1	NUM
ctmj-149	64	2	)	)	PUNCT
ctmj-149	64	3	.	.	PUNCT
ctmj-149	65	1	all	all	DET
ctmj-149	65	2	three	three	NUM
ctmj-149	65	3	tj	tj	NOUN
ctmj-149	65	4	proteins	protein	NOUN
ctmj-149	65	5	showed	show	VERB
ctmj-149	65	6	positive	positive	ADJ
ctmj-149	65	7	staining	staining	NOUN
ctmj-149	65	8	in	in	ADP
ctmj-149	65	9	both	both	DET
ctmj-149	65	10	cell	cell	NOUN
ctmj-149	65	11	types	type	NOUN
ctmj-149	65	12	and	and	CCONJ
ctmj-149	65	13	occludin	occludin	NOUN
ctmj-149	65	14	stained	stain	VERB
ctmj-149	65	15	red	red	NOUN
ctmj-149	65	16	,	,	PUNCT
ctmj-149	65	17	claudin1and	claudin1and	CCONJ
ctmj-149	65	18	f	f	X
ctmj-149	65	19	-	-	PUNCT
ctmj-149	65	20	actin	actin	NOUN
ctmj-149	65	21	stained	stain	VERB
ctmj-149	65	22	green	green	NOUN
ctmj-149	65	23	,	,	PUNCT
ctmj-149	65	24	and	and	CCONJ
ctmj-149	65	25	the	the	DET
ctmj-149	65	26	nuclei	nucleus	NOUN
ctmj-149	65	27	stained	stain	VERB
ctmj-149	65	28	blue	blue	NOUN
ctmj-149	65	29	.	.	PUNCT
ctmj-149	66	1	both	both	DET
ctmj-149	66	2	cell	cell	NOUN
ctmj-149	66	3	types	type	NOUN
ctmj-149	66	4	had	have	VERB
ctmj-149	66	5	similar	similar	ADJ
ctmj-149	66	6	tj	tj	NOUN
ctmj-149	66	7	barrier	barrier	NOUN
ctmj-149	66	8	function	function	NOUN
ctmj-149	66	9	systems	system	NOUN
ctmj-149	66	10	.	.	PUNCT
ctmj-149	67	1	aod	aod	PROPN
ctmj-149	67	2	after	after	ADP
ctmj-149	67	3	treatment	treatment	NOUN
ctmj-149	67	4	with	with	ADP
ctmj-149	67	5	puerarin	puerarin	NOUN
ctmj-149	67	6	and	and	CCONJ
ctmj-149	67	7	paeoniflorin	paeoniflorin	NOUN
ctmj-149	67	8	,	,	PUNCT
ctmj-149	67	9	the	the	DET
ctmj-149	67	10	visual	visual	ADJ
ctmj-149	67	11	morphology	morphology	NOUN
ctmj-149	67	12	of	of	ADP
ctmj-149	67	13	occludin	occludin	PROPN
ctmj-149	67	14	,	,	PUNCT
ctmj-149	67	15	claudin-1	claudin-1	PROPN
ctmj-149	67	16	,	,	PUNCT
ctmj-149	67	17	and	and	CCONJ
ctmj-149	67	18	f	f	X
ctmj-149	67	19	-	-	PUNCT
ctmj-149	67	20	actin	actin	NOUN
ctmj-149	67	21	in	in	ADP
ctmj-149	67	22	both	both	DET
ctmj-149	67	23	kinds	kind	NOUN
ctmj-149	67	24	of	of	ADP
ctmj-149	67	25	cells	cell	NOUN
ctmj-149	67	26	was	be	AUX
ctmj-149	67	27	not	not	PART
ctmj-149	67	28	difference	difference	NOUN
ctmj-149	67	29	from	from	ADP
ctmj-149	67	30	that	that	PRON
ctmj-149	67	31	of	of	ADP
ctmj-149	67	32	the	the	DET
ctmj-149	67	33	untreated	untreated	ADJ
ctmj-149	67	34	cells	cell	NOUN
ctmj-149	67	35	.	.	PUNCT
ctmj-149	68	1	however	however	ADV
ctmj-149	68	2	,	,	PUNCT
ctmj-149	68	3	incubation	incubation	NOUN
ctmj-149	68	4	with	with	ADP
ctmj-149	68	5	menthol	menthol	NOUN
ctmj-149	68	6	,	,	PUNCT
ctmj-149	68	7	decreased	decrease	VERB
ctmj-149	68	8	the	the	DET
ctmj-149	68	9	tj	tj	NOUN
ctmj-149	68	10	proteins	protein	NOUN
ctmj-149	68	11	in	in	ADP
ctmj-149	68	12	both	both	CCONJ
ctmj-149	68	13	mdck	mdck	PROPN
ctmj-149	68	14	and	and	CCONJ
ctmj-149	68	15	mdckmdr1	mdckmdr1	NOUN
ctmj-149	68	16	-	-	PUNCT
ctmj-149	68	17	cells	cell	NOUN
ctmj-149	68	18	and	and	CCONJ
ctmj-149	68	19	the	the	DET
ctmj-149	68	20	morphology	morphology	NOUN
ctmj-149	68	21	was	be	AUX
ctmj-149	68	22	hardly	hardly	ADV
ctmj-149	68	23	observed	observe	VERB
ctmj-149	68	24	(	(	PUNCT
ctmj-149	68	25	fig	fig	NOUN
ctmj-149	68	26	.	.	PUNCT
ctmj-149	69	1	1a	1a	NUM
ctmj-149	69	2	,	,	PUNCT
ctmj-149	69	3	b	b	NOUN
ctmj-149	69	4	,	,	PUNCT
ctmj-149	69	5	respectively	respectively	ADV
ctmj-149	69	6	)	)	PUNCT
ctmj-149	69	7	.	.	PUNCT
ctmj-149	70	1	fig	fig	NOUN
ctmj-149	70	2	.	.	PUNCT
ctmj-149	71	1	1	1	NUM
ctmj-149	71	2	effect	effect	NOUN
ctmj-149	71	3	of	of	ADP
ctmj-149	71	4	puerarin	puerarin	NOUN
ctmj-149	71	5	,	,	PUNCT
ctmj-149	71	6	paeoniflorin	paeoniflorin	NOUN
ctmj-149	71	7	,	,	PUNCT
ctmj-149	71	8	and	and	CCONJ
ctmj-149	71	9	menthol	menthol	VERB
ctmj-149	71	10	on	on	ADP
ctmj-149	71	11	tight	tight	ADJ
ctmj-149	71	12	junction	junction	NOUN
ctmj-149	71	13	(	(	PUNCT
ctmj-149	71	14	tj	tj	NOUN
ctmj-149	71	15	)	)	PUNCT
ctmj-149	71	16	proteins	protein	NOUN
ctmj-149	71	17	in	in	ADP
ctmj-149	71	18	(	(	PUNCT
ctmj-149	71	19	a	a	PRON
ctmj-149	71	20	)	)	PUNCT
ctmj-149	71	21	madinedarby	madinedarby	NOUN
ctmj-149	71	22	canine	canine	NOUN
ctmj-149	71	23	kidney	kidney	PROPN
ctmj-149	71	24	epithelial	epithelial	ADJ
ctmj-149	71	25	(	(	PUNCT
ctmj-149	71	26	mdck	mdck	NUM
ctmj-149	71	27	)	)	PUNCT
ctmj-149	71	28	and	and	CCONJ
ctmj-149	71	29	(	(	PUNCT
ctmj-149	71	30	b	b	X
ctmj-149	71	31	)	)	PUNCT
ctmj-149	71	32	mdck	mdck	ADJ
ctmj-149	71	33	-	-	PUNCT
ctmj-149	71	34	multi	multi	ADJ
ctmj-149	71	35	-	-	ADJ
ctmj-149	71	36	drug	drug	ADJ
ctmj-149	71	37	resistance	resistance	NOUN
ctmj-149	71	38	1	1	NUM
ctmj-149	71	39	(	(	PUNCT
ctmj-149	71	40	mdr1	mdr1	PROPN
ctmj-149	71	41	)	)	PUNCT
ctmj-149	71	42	cells	cell	NOUN
ctmj-149	71	43	(	(	PUNCT
ctmj-149	71	44	×600	×600	PROPN
ctmj-149	71	45	)	)	PUNCT
ctmj-149	71	46	.	.	PUNCT
ctmj-149	72	1	(	(	PUNCT
ctmj-149	72	2	a	a	X
ctmj-149	72	3	)	)	PUNCT
ctmj-149	72	4	immunocytochemistry	immunocytochemistry	NOUN
ctmj-149	72	5	for	for	ADP
ctmj-149	72	6	occluding	occlude	VERB
ctmj-149	72	7	,	,	PUNCT
ctmj-149	72	8	claudin-1	claudin-1	PROPN
ctmj-149	72	9	,	,	PUNCT
ctmj-149	72	10	and	and	CCONJ
ctmj-149	72	11	f	f	X
ctmj-149	72	12	-	-	PUNCT
ctmj-149	72	13	actin	actin	NOUN
ctmj-149	72	14	in	in	ADP
ctmj-149	72	15	mdck	mdck	PROPN
ctmj-149	72	16	cells	cell	NOUN
ctmj-149	72	17	with	with	ADP
ctmj-149	72	18	puerarin	puerarin	NOUN
ctmj-149	72	19	or	or	CCONJ
ctmj-149	72	20	paeoniflorin	paeoniflorin	NOUN
ctmj-149	72	21	showed	show	VERB
ctmj-149	72	22	similar	similar	ADJ
ctmj-149	72	23	fluorescent	fluorescent	ADJ
ctmj-149	72	24	morphology	morphology	NOUN
ctmj-149	72	25	with	with	ADP
ctmj-149	72	26	the	the	DET
ctmj-149	72	27	control	control	NOUN
ctmj-149	72	28	group	group	NOUN
ctmj-149	72	29	.	.	PUNCT
ctmj-149	73	1	all	all	DET
ctmj-149	73	2	three	three	NUM
ctmj-149	73	3	proteins	protein	NOUN
ctmj-149	73	4	were	be	AUX
ctmj-149	73	5	deceased	decease	VERB
ctmj-149	73	6	in	in	ADP
ctmj-149	73	7	mdck	mdck	PROPN
ctmj-149	73	8	cells	cell	NOUN
ctmj-149	73	9	by	by	ADP
ctmj-149	73	10	menthol	menthol	NOUN
ctmj-149	73	11	.	.	PUNCT
ctmj-149	74	1	(	(	PUNCT
ctmj-149	74	2	b	b	X
ctmj-149	74	3	)	)	PUNCT
ctmj-149	74	4	fluorescence	fluorescence	NOUN
ctmj-149	74	5	intensity	intensity	NOUN
ctmj-149	74	6	in	in	ADP
ctmj-149	74	7	mdck	mdck	PROPN
ctmj-149	74	8	-	-	PUNCT
ctmj-149	74	9	mdr1	mdr1	PROPN
ctmj-149	74	10	cells	cell	NOUN
ctmj-149	74	11	with	with	ADP
ctmj-149	74	12	different	different	ADJ
ctmj-149	74	13	compounds	compound	NOUN
ctmj-149	74	14	was	be	AUX
ctmj-149	74	15	similar	similar	ADJ
ctmj-149	74	16	to	to	ADP
ctmj-149	74	17	that	that	PRON
ctmj-149	74	18	in	in	ADP
ctmj-149	74	19	mdck	mdck	PROPN
ctmj-149	74	20	cells	cell	NOUN
ctmj-149	74	21	.	.	PUNCT
ctmj-149	75	1	scale	scale	NOUN
ctmj-149	75	2	bar	bar	NOUN
ctmj-149	75	3	corresponds	correspond	VERB
ctmj-149	75	4	to	to	ADP
ctmj-149	75	5	1.0	1.0	NUM
ctmj-149	75	6	mm	mm	NOUN
ctmj-149	75	7	.	.	PUNCT
ctmj-149	76	1	changes	change	NOUN
ctmj-149	76	2	in	in	ADP
ctmj-149	76	3	aod	aod	PROPN
ctmj-149	76	4	of	of	ADP
ctmj-149	76	5	tj	tj	NOUN
ctmj-149	76	6	proteins	protein	NOUN
ctmj-149	76	7	after	after	ADP
ctmj-149	76	8	treatment	treatment	NOUN
ctmj-149	76	9	with	with	ADP
ctmj-149	76	10	different	different	ADJ
ctmj-149	76	11	compounds	compound	NOUN
ctmj-149	76	12	fluorescence	fluorescence	ADJ
ctmj-149	76	13	intensity	intensity	NOUN
ctmj-149	76	14	of	of	ADP
ctmj-149	76	15	the	the	DET
ctmj-149	76	16	immunofluorescent	immunofluorescent	NOUN
ctmj-149	76	17	images	image	NOUN
ctmj-149	76	18	was	be	AUX
ctmj-149	76	19	semi	semi	ADJ
ctmj-149	76	20	-	-	ADJ
ctmj-149	76	21	quantitatively	quantitatively	ADV
ctmj-149	76	22	analyzed	analyze	VERB
ctmj-149	76	23	.	.	PUNCT
ctmj-149	77	1	aod	aod	PROPN
ctmj-149	77	2	values	value	NOUN
ctmj-149	77	3	of	of	ADP
ctmj-149	77	4	each	each	DET
ctmj-149	77	5	protein	protein	NOUN
ctmj-149	77	6	were	be	AUX
ctmj-149	77	7	calculated	calculate	VERB
ctmj-149	77	8	using	use	VERB
ctmj-149	77	9	imagej	imagej	ADJ
ctmj-149	77	10	software	software	NOUN
ctmj-149	77	11	and	and	CCONJ
ctmj-149	77	12	statis	statis	ADJ
ctmj-149	77	13	tical	tical	ADJ
ctmj-149	77	14	analysis	analysis	NOUN
ctmj-149	77	15	was	be	AUX
ctmj-149	77	16	conducted	conduct	VERB
ctmj-149	77	17	(	(	PUNCT
ctmj-149	77	18	fig	fig	NOUN
ctmj-149	77	19	.	.	PUNCT
ctmj-149	78	1	2	2	NUM
ctmj-149	78	2	)	)	PUNCT
ctmj-149	78	3	.	.	PUNCT
ctmj-149	79	1	the	the	DET
ctmj-149	79	2	control	control	NOUN
ctmj-149	79	3	,	,	PUNCT
ctmj-149	79	4	puerarin	puerarin	NOUN
ctmj-149	79	5	,	,	PUNCT
ctmj-149	79	6	and	and	CCONJ
ctmj-149	79	7	paeoniflorin	paeoniflorin	NOUN
ctmj-149	79	8	groups	group	NOUN
ctmj-149	79	9	showed	show	VERB
ctmj-149	79	10	similar	similar	ADJ
ctmj-149	79	11	approximate	approximate	ADJ
ctmj-149	79	12	rela	rela	PROPN
ctmj-149	79	13	tive	tive	PROPN
ctmj-149	79	14	aod	aod	PROPN
ctmj-149	79	15	values	value	NOUN
ctmj-149	79	16	in	in	ADP
ctmj-149	79	17	the	the	DET
ctmj-149	79	18	mdck	mdck	PROPN
ctmj-149	79	19	and	and	CCONJ
ctmj-149	79	20	mdck	mdck	PROPN
ctmj-149	79	21	-	-	PUNCT
ctmj-149	79	22	mdr1	mdr1	PROPN
ctmj-149	79	23	cells	cell	NOUN
ctmj-149	79	24	,	,	PUNCT
ctmj-149	79	25	while	while	SCONJ
ctmj-149	79	26	the	the	DET
ctmj-149	79	27	menthol	menthol	NOUN
ctmj-149	79	28	group	group	NOUN
ctmj-149	79	29	was	be	AUX
ctmj-149	79	30	significantly	significantly	ADV
ctmj-149	79	31	different	different	ADJ
ctmj-149	79	32	compared	compare	VERB
ctmj-149	79	33	to	to	ADP
ctmj-149	79	34	ctmj	ctmj	NOUN
ctmj-149	80	1	|	|	ADV
ctmj-149	80	2	traditionalmedicinejournals.com	traditionalmedicinejournals.com	X
ctmj-149	80	3	chinese	chinese	ADJ
ctmj-149	80	4	traditional	traditional	ADJ
ctmj-149	80	5	medicine	medicine	NOUN
ctmj-149	80	6	journal	journal	NOUN
ctmj-149	80	7	|	|	ADV
ctmj-149	80	8	2024	2024	NUM
ctmj-149	80	9	|	|	ADV
ctmj-149	80	10	vol	vol	NOUN
ctmj-149	80	11	7	7	NUM
ctmj-149	80	12	|	|	NOUN
ctmj-149	80	13	issue	issue	VERB
ctmj-149	80	14	1	1	NUM
ctmj-149	80	15	issn	issn	X
ctmj-149	80	16	:	:	PUNCT
ctmj-149	80	17	2693	2693	NUM
ctmj-149	80	18	6356	6356	NUM
ctmj-149	80	19	2024	2024	NUM
ctmj-149	80	20	|	|	ADV
ctmj-149	80	21	vol	vol	NOUN
ctmj-149	80	22	1	1	NUM
ctmj-149	80	23	|	|	NOUN
ctmj-149	80	24	issue	issue	VERB
ctmj-149	80	25	1	1	NUM
ctmj-149	80	26	the	the	DET
ctmj-149	80	27	control	control	NOUN
ctmj-149	80	28	group	group	NOUN
ctmj-149	80	29	(	(	PUNCT
ctmj-149	80	30	p	p	X
ctmj-149	80	31	<	<	X
ctmj-149	80	32	.05	.05	NUM
ctmj-149	80	33	)	)	PUNCT
ctmj-149	80	34	.	.	PUNCT
ctmj-149	81	1	changes	change	NOUN
ctmj-149	81	2	in	in	ADP
ctmj-149	81	3	teer	teer	NOUN
ctmj-149	81	4	of	of	ADP
ctmj-149	81	5	cells	cell	NOUN
ctmj-149	81	6	treated	treat	VERB
ctmj-149	81	7	with	with	ADP
ctmj-149	81	8	various	various	ADJ
ctmj-149	81	9	compounds	compound	NOUN
ctmj-149	81	10	to	to	PART
ctmj-149	81	11	determine	determine	VERB
ctmj-149	81	12	the	the	DET
ctmj-149	81	13	effects	effect	NOUN
ctmj-149	81	14	of	of	ADP
ctmj-149	81	15	the	the	DET
ctmj-149	81	16	compounds	compound	NOUN
ctmj-149	81	17	on	on	ADP
ctmj-149	81	18	the	the	DET
ctmj-149	81	19	function	function	NOUN
ctmj-149	81	20	of	of	ADP
ctmj-149	81	21	the	the	DET
ctmj-149	81	22	tj	tj	NOUN
ctmj-149	81	23	barrier	barrier	NOUN
ctmj-149	81	24	,	,	PUNCT
ctmj-149	81	25	we	we	PRON
ctmj-149	81	26	measured	measure	VERB
ctmj-149	81	27	the	the	DET
ctmj-149	81	28	teer	teer	NOUN
ctmj-149	81	29	values	value	NOUN
ctmj-149	81	30	of	of	ADP
ctmj-149	81	31	mdck	mdck	PROPN
ctmj-149	81	32	and	and	CCONJ
ctmj-149	81	33	mdck	mdck	PROPN
ctmj-149	81	34	-	-	PUNCT
ctmj-149	81	35	mdr1	mdr1	PROPN
ctmj-149	81	36	cells	cell	NOUN
ctmj-149	81	37	after	after	ADP
ctmj-149	81	38	exposure	exposure	NOUN
ctmj-149	81	39	to	to	ADP
ctmj-149	81	40	the	the	DET
ctmj-149	81	41	various	various	ADJ
ctmj-149	81	42	fig	fig	NOUN
ctmj-149	81	43	.	.	PUNCT
ctmj-149	82	1	2	2	NUM
ctmj-149	82	2	change	change	NOUN
ctmj-149	82	3	in	in	ADP
ctmj-149	82	4	relative	relative	ADJ
ctmj-149	82	5	average	average	ADJ
ctmj-149	82	6	optical	optical	ADJ
ctmj-149	82	7	density	density	NOUN
ctmj-149	82	8	(	(	PUNCT
ctmj-149	82	9	aod	aod	PROPN
ctmj-149	82	10	)	)	PUNCT
ctmj-149	82	11	of	of	ADP
ctmj-149	82	12	occludin	occludin	PROPN
ctmj-149	82	13	,	,	PUNCT
ctmj-149	82	14	claudin-1	claudin-1	PROPN
ctmj-149	82	15	,	,	PUNCT
ctmj-149	82	16	and	and	CCONJ
ctmj-149	82	17	f	f	X
ctmj-149	82	18	-	-	PUNCT
ctmj-149	82	19	actin	actin	NOUN
ctmj-149	82	20	in	in	ADP
ctmj-149	82	21	(	(	PUNCT
ctmj-149	82	22	a	a	PRON
ctmj-149	82	23	)	)	PUNCT
ctmj-149	82	24	madinedarby	madinedarby	NOUN
ctmj-149	82	25	canine	canine	NOUN
ctmj-149	82	26	kidney	kidney	PROPN
ctmj-149	82	27	(	(	PUNCT
ctmj-149	82	28	mdck	mdck	NOUN
ctmj-149	82	29	)	)	PUNCT
ctmj-149	82	30	epithelial	epithelial	ADJ
ctmj-149	82	31	and	and	CCONJ
ctmj-149	82	32	(	(	PUNCT
ctmj-149	82	33	b	b	NOUN
ctmj-149	82	34	)	)	PUNCT
ctmj-149	82	35	mdck	mdck	ADJ
ctmj-149	82	36	-	-	PUNCT
ctmj-149	82	37	multi	multi	ADJ
ctmj-149	82	38	-	-	ADJ
ctmj-149	82	39	drug	drug	ADJ
ctmj-149	82	40	resistance	resistance	NOUN
ctmj-149	82	41	1	1	NUM
ctmj-149	82	42	(	(	PUNCT
ctmj-149	82	43	mdr1	mdr1	PROPN
ctmj-149	82	44	)	)	PUNCT
ctmj-149	82	45	cells	cell	NOUN
ctmj-149	82	46	after	after	ADP
ctmj-149	82	47	treatment	treatment	NOUN
ctmj-149	82	48	with	with	ADP
ctmj-149	82	49	different	different	ADJ
ctmj-149	82	50	compounds	compound	NOUN
ctmj-149	82	51	.	.	PUNCT
ctmj-149	83	1	(	(	PUNCT
ctmj-149	83	2	a	a	X
ctmj-149	83	3	)	)	PUNCT
ctmj-149	83	4	relative	relative	ADJ
ctmj-149	83	5	aod	aod	PROPN
ctmj-149	83	6	values	value	NOUN
ctmj-149	83	7	of	of	ADP
ctmj-149	83	8	tight	tight	ADJ
ctmj-149	83	9	junction	junction	NOUN
ctmj-149	83	10	(	(	PUNCT
ctmj-149	83	11	tj	tj	NOUN
ctmj-149	83	12	)	)	PUNCT
ctmj-149	83	13	proteins	protein	NOUN
ctmj-149	83	14	in	in	ADP
ctmj-149	83	15	mdck	mdck	PROPN
ctmj-149	83	16	cells	cell	NOUN
ctmj-149	83	17	treated	treat	VERB
ctmj-149	83	18	with	with	ADP
ctmj-149	83	19	puerarin	puerarin	NOUN
ctmj-149	83	20	or	or	CCONJ
ctmj-149	83	21	paeoniflorin	paeoniflorin	NOUN
ctmj-149	83	22	showed	show	VERB
ctmj-149	83	23	no	no	DET
ctmj-149	83	24	signifi	signifi	NOUN
ctmj-149	83	25	ca	can	AUX
ctmj-149	83	26	nt	not	PART
ctmj-149	83	27	difference	difference	VERB
ctmj-149	83	28	compared	compare	VERB
ctmj-149	83	29	to	to	ADP
ctmj-149	83	30	the	the	DET
ctmj-149	83	31	control	control	NOUN
ctmj-149	83	32	group	group	NOUN
ctmj-149	83	33	while	while	SCONJ
ctmj-149	83	34	aod	aod	PROPN
ctmj-149	83	35	values	value	NOUN
ctmj-149	83	36	of	of	ADP
ctmj-149	83	37	the	the	DET
ctmj-149	83	38	menthol	menthol	NOUN
ctmj-149	83	39	group	group	NOUN
ctmj-149	83	40	were	be	AUX
ctmj-149	83	41	significantly	significantly	ADV
ctmj-149	83	42	reduced	reduce	VERB
ctmj-149	83	43	.	.	PUNCT
ctmj-149	84	1	(	(	PUNCT
ctmj-149	84	2	b	b	X
ctmj-149	84	3	)	)	PUNCT
ctmj-149	84	4	relative	relative	ADJ
ctmj-149	84	5	aod	aod	PROPN
ctmj-149	84	6	values	value	NOUN
ctmj-149	84	7	in	in	ADP
ctmj-149	84	8	mdck	mdck	PROPN
ctmj-149	84	9	-	-	PUNCT
ctmj-149	84	10	mdr1	mdr1	PROPN
ctmj-149	84	11	cells	cell	NOUN
ctmj-149	84	12	treated	treat	VERB
ctmj-149	84	13	with	with	ADP
ctmj-149	84	14	different	different	ADJ
ctmj-149	84	15	compounds	compound	NOUN
ctmj-149	84	16	were	be	AUX
ctmj-149	84	17	the	the	DET
ctmj-149	84	18	same	same	ADJ
ctmj-149	84	19	as	as	ADP
ctmj-149	84	20	in	in	ADP
ctmj-149	84	21	mdck	mdck	PROPN
ctmj-149	84	22	cells	cell	NOUN
ctmj-149	84	23	.	.	PUNCT
ctmj-149	85	1	only	only	ADV
ctmj-149	85	2	menthol	menthol	VERB
ctmj-149	85	3	reduced	reduce	VERB
ctmj-149	85	4	aod	aod	PROPN
ctmj-149	85	5	of	of	ADP
ctmj-149	85	6	all	all	DET
ctmj-149	85	7	three	three	NUM
ctmj-149	85	8	proteins	protein	NOUN
ctmj-149	85	9	.	.	PUNCT
ctmj-149	86	1	data	datum	NOUN
ctmj-149	86	2	presented	present	VERB
ctmj-149	86	3	as	as	ADP
ctmj-149	86	4	mean	mean	NOUN
ctmj-149	86	5	(	(	PUNCT
ctmj-149	86	6	sd	sd	NOUN
ctmj-149	86	7	)	)	PUNCT
ctmj-149	86	8	(	(	PUNCT
ctmj-149	86	9	n	n	NOUN
ctmj-149	86	10	z	z	NOUN
ctmj-149	86	11	3	3	NUM
ctmj-149	86	12	)	)	PUNCT
ctmj-149	86	13	.	.	PUNCT
ctmj-149	86	14	)	)	PUNCT
ctmj-149	87	1	p	p	X
ctmj-149	87	2	<	<	X
ctmj-149	87	3	.05	.05	NUM
ctmj-149	87	4	compared	compare	VERB
ctmj-149	87	5	to	to	ADP
ctmj-149	87	6	control	control	PROPN
ctmj-149	87	7	group	group	NOUN
ctmj-149	87	8	.	.	PUNCT
ctmj-149	88	1	compounds	compound	VERB
ctmj-149	88	2	for	for	ADP
ctmj-149	88	3	up	up	ADP
ctmj-149	88	4	to	to	PART
ctmj-149	88	5	3	3	NUM
ctmj-149	88	6	h.	h.	NOUN
ctmj-149	88	7	teer	teer	PROPN
ctmj-149	88	8	values	value	NOUN
ctmj-149	88	9	of	of	ADP
ctmj-149	88	10	each	each	DET
ctmj-149	88	11	group	group	NOUN
ctmj-149	88	12	treated	treat	VERB
ctmj-149	88	13	with	with	ADP
ctmj-149	88	14	the	the	DET
ctmj-149	88	15	compounds	compound	NOUN
ctmj-149	88	16	for	for	ADP
ctmj-149	88	17	different	different	ADJ
ctmj-149	88	18	times	time	NOUN
ctmj-149	88	19	were	be	AUX
ctmj-149	88	20	statistically	statistically	ADV
ctmj-149	88	21	compared	compare	VERB
ctmj-149	88	22	with	with	ADP
ctmj-149	88	23	those	those	PRON
ctmj-149	88	24	of	of	ADP
ctmj-149	88	25	the	the	DET
ctmj-149	88	26	control	control	NOUN
ctmj-149	88	27	group	group	NOUN
ctmj-149	88	28	(	(	PUNCT
ctmj-149	88	29	fig	fig	NOUN
ctmj-149	88	30	.	.	PUNCT
ctmj-149	89	1	3	3	NUM
ctmj-149	89	2	)	)	PUNCT
ctmj-149	89	3	.	.	PUNCT
ctmj-149	90	1	mdck	mdck	PROPN
ctmj-149	90	2	cells	cell	NOUN
ctmj-149	90	3	(	(	PUNCT
ctmj-149	90	4	fig	fig	NOUN
ctmj-149	90	5	.	.	PUNCT
ctmj-149	90	6	3a	3a	NUM
ctmj-149	90	7	)	)	PUNCT
ctmj-149	90	8	treated	treat	VERB
ctmj-149	90	9	with	with	ADP
ctmj-149	90	10	puerarin	puerarin	NOUN
ctmj-149	90	11	,	,	PUNCT
ctmj-149	90	12	paeoniflorin	paeoniflorin	NOUN
ctmj-149	90	13	,	,	PUNCT
ctmj-149	90	14	and	and	CCONJ
ctmj-149	90	15	pp	pp	ADV
ctmj-149	90	16	exhibited	exhibit	VERB
ctmj-149	90	17	similar	similar	ADJ
ctmj-149	90	18	changes	change	NOUN
ctmj-149	90	19	in	in	ADP
ctmj-149	90	20	teer	teer	NOUN
ctmj-149	90	21	compared	compare	VERB
ctmj-149	90	22	to	to	ADP
ctmj-149	90	23	the	the	DET
ctmj-149	90	24	control	control	NOUN
ctmj-149	90	25	group	group	NOUN
ctmj-149	90	26	in	in	ADP
ctmj-149	90	27	the	the	DET
ctmj-149	90	28	a	a	PRON
ctmj-149	90	29	/	/	SYM
ctmj-149	90	30	b	b	NOUN
ctmj-149	90	31	and	and	CCONJ
ctmj-149	90	32	b	b	PROPN
ctmj-149	90	33	/	/	SYM
ctmj-149	90	34	a	a	DET
ctmj-149	90	35	transport	transport	NOUN
ctmj-149	90	36	processes	process	NOUN
ctmj-149	90	37	.	.	PUNCT
ctmj-149	91	1	at	at	ADP
ctmj-149	91	2	90	90	NUM
ctmj-149	91	3	min	min	NOUN
ctmj-149	91	4	,	,	PUNCT
ctmj-149	91	5	teer	teer	NOUN
ctmj-149	91	6	of	of	ADP
ctmj-149	91	7	the	the	DET
ctmj-149	91	8	menthol	menthol	NOUN
ctmj-149	91	9	,	,	PUNCT
ctmj-149	91	10	pm	pm	NOUN
ctmj-149	91	11	,	,	PUNCT
ctmj-149	91	12	and	and	CCONJ
ctmj-149	91	13	ppm	ppm	ADJ
ctmj-149	91	14	groups	group	NOUN
ctmj-149	91	15	decreased	decrease	VERB
ctmj-149	91	16	significantly	significantly	ADV
ctmj-149	91	17	compared	compare	VERB
ctmj-149	91	18	with	with	ADP
ctmj-149	91	19	that	that	PRON
ctmj-149	91	20	of	of	ADP
ctmj-149	91	21	the	the	DET
ctmj-149	91	22	control	control	NOUN
ctmj-149	91	23	group	group	NOUN
ctmj-149	91	24	(	(	PUNCT
ctmj-149	91	25	p	p	X
ctmj-149	91	26	<	<	X
ctmj-149	91	27	.05	.05	NUM
ctmj-149	91	28	)	)	PUNCT
ctmj-149	91	29	.	.	PUNCT
ctmj-149	92	1	in	in	ADP
ctmj-149	92	2	mdck	mdck	PROPN
ctmj-149	92	3	-	-	PUNCT
ctmj-149	92	4	mdr1	mdr1	PROPN
ctmj-149	92	5	cells	cell	NOUN
ctmj-149	92	6	(	(	PUNCT
ctmj-149	92	7	fig	fig	NOUN
ctmj-149	92	8	.	.	PUNCT
ctmj-149	93	1	3b	3b	NUM
ctmj-149	93	2	)	)	PUNCT
ctmj-149	94	1	,	,	PUNCT
ctmj-149	94	2	groups	group	NOUN
ctmj-149	94	3	not	not	PART
ctmj-149	94	4	treated	treat	VERB
ctmj-149	94	5	with	with	ADP
ctmj-149	94	6	menthol	menthol	NOUN
ctmj-149	94	7	exhibited	exhibit	VERB
ctmj-149	94	8	a	a	DET
ctmj-149	94	9	steady	steady	ADJ
ctmj-149	94	10	teer	teer	NOUN
ctmj-149	94	11	change	change	NOUN
ctmj-149	94	12	similar	similar	ADJ
ctmj-149	94	13	to	to	ADP
ctmj-149	94	14	the	the	DET
ctmj-149	94	15	control	control	NOUN
ctmj-149	94	16	group	group	NOUN
ctmj-149	94	17	and	and	CCONJ
ctmj-149	94	18	mentholtreated	mentholtreated	ADJ
ctmj-149	94	19	groups	group	NOUN
ctmj-149	94	20	showed	show	VERB
ctmj-149	94	21	a	a	DET
ctmj-149	94	22	significant	significant	ADJ
ctmj-149	94	23	decrease	decrease	NOUN
ctmj-149	94	24	at	at	ADP
ctmj-149	94	25	120	120	NUM
ctmj-149	94	26	min(p	min(p	PROPN
ctmj-149	94	27	<	<	X
ctmj-149	94	28	.05)in	.05)in	NOUN
ctmj-149	95	1	both	both	CCONJ
ctmj-149	95	2	the	the	DET
ctmj-149	95	3	a	a	DET
ctmj-149	95	4	/	/	SYM
ctmj-149	95	5	b	b	NOUN
ctmj-149	95	6	and	and	CCONJ
ctmj-149	95	7	b	b	PROPN
ctmj-149	95	8	/	/	SYM
ctmj-149	95	9	a	a	DET
ctmj-149	95	10	transport	transport	NOUN
ctmj-149	95	11	processes	process	NOUN
ctmj-149	95	12	compared	compare	VERB
ctmj-149	95	13	to	to	ADP
ctmj-149	95	14	control	control	NOUN
ctmj-149	95	15	.	.	PUNCT
ctmj-149	96	1	discussion	discussion	NOUN
ctmj-149	96	2	use	use	NOUN
ctmj-149	96	3	of	of	ADP
ctmj-149	96	4	both	both	PRON
ctmj-149	96	5	in	in	ADP
ctmj-149	96	6	vivo	vivo	NOUN
ctmj-149	96	7	and	and	CCONJ
ctmj-149	96	8	in	in	ADP
ctmj-149	96	9	vitro	vitro	X
ctmj-149	96	10	methods	method	NOUN
ctmj-149	96	11	has	have	AUX
ctmj-149	96	12	led	lead	VERB
ctmj-149	96	13	to	to	ADP
ctmj-149	96	14	the	the	DET
ctmj-149	96	15	elucidation	elucidation	NOUN
ctmj-149	96	16	of	of	ADP
ctmj-149	96	17	certain	certain	ADJ
ctmj-149	96	18	aspects	aspect	NOUN
ctmj-149	96	19	of	of	ADP
ctmj-149	96	20	the	the	DET
ctmj-149	96	21	drug	drug	NOUN
ctmj-149	96	22	transport	transport	NOUN
ctmj-149	96	23	process	process	NOUN
ctmj-149	96	24	across	across	ADP
ctmj-149	96	25	the	the	DET
ctmj-149	96	26	bbb	bbb	PROPN
ctmj-149	96	27	.	.	PUNCT
ctmj-149	97	1	in	in	ADP
ctmj-149	97	2	vivo	vivo	ADJ
ctmj-149	97	3	studies	study	NOUN
ctmj-149	97	4	of	of	ADP
ctmj-149	97	5	the	the	DET
ctmj-149	97	6	bbb	bbb	PROPN
ctmj-149	97	7	provide	provide	VERB
ctmj-149	97	8	valuable	valuable	ADJ
ctmj-149	97	9	observational	observational	ADJ
ctmj-149	97	10	information	information	NOUN
ctmj-149	97	11	and	and	CCONJ
ctmj-149	97	12	direct	direct	ADJ
ctmj-149	97	13	analysis	analysis	NOUN
ctmj-149	97	14	of	of	ADP
ctmj-149	97	15	drug	drug	NOUN
ctmj-149	97	16	permeation	permeation	NOUN
ctmj-149	97	17	processes	process	NOUN
ctmj-149	97	18	such	such	ADJ
ctmj-149	97	19	as	as	ADP
ctmj-149	97	20	drug	drug	NOUN
ctmj-149	97	21	distribution	distribution	NOUN
ctmj-149	97	22	in	in	ADP
ctmj-149	97	23	each	each	DET
ctmj-149	97	24	brain	brain	NOUN
ctmj-149	97	25	region	region	NOUN
ctmj-149	97	26	.	.	PUNCT
ctmj-149	98	1	however	however	ADV
ctmj-149	98	2	,	,	PUNCT
ctmj-149	98	3	there	there	PRON
ctmj-149	98	4	are	be	VERB
ctmj-149	98	5	some	some	DET
ctmj-149	98	6	limitations	limitation	NOUN
ctmj-149	98	7	and	and	CCONJ
ctmj-149	98	8	shortcomings	shortcoming	NOUN
ctmj-149	98	9	to	to	ADP
ctmj-149	98	10	this	this	DET
ctmj-149	98	11	method	method	NOUN
ctmj-149	98	12	including	include	VERB
ctmj-149	98	13	the	the	DET
ctmj-149	98	14	laborious	laborious	ADJ
ctmj-149	98	15	nature	nature	NOUN
ctmj-149	98	16	of	of	ADP
ctmj-149	98	17	the	the	DET
ctmj-149	98	18	experiments	experiment	NOUN
ctmj-149	98	19	,	,	PUNCT
ctmj-149	98	20	individual	individual	ADJ
ctmj-149	98	21	differences	difference	NOUN
ctmj-149	98	22	,	,	PUNCT
ctmj-149	98	23	and	and	CCONJ
ctmj-149	98	24	complicated	complicated	ADJ
ctmj-149	98	25	analytical	analytical	ADJ
ctmj-149	98	26	methods	method	NOUN
ctmj-149	98	27	.	.	PUNCT
ctmj-149	99	1	accordingly	accordingly	ADV
ctmj-149	99	2	,	,	PUNCT
ctmj-149	99	3	development	development	NOUN
ctmj-149	99	4	of	of	ADP
ctmj-149	99	5	in	in	ADP
ctmj-149	99	6	vitro	vitro	X
ctmj-149	99	7	models	model	NOUN
ctmj-149	99	8	is	be	AUX
ctmj-149	99	9	highly	highly	ADV
ctmj-149	99	10	desired	desire	VERB
ctmj-149	99	11	to	to	PART
ctmj-149	99	12	facilitate	facilitate	VERB
ctmj-149	99	13	the	the	DET
ctmj-149	99	14	clarification	clarification	NOUN
ctmj-149	99	15	of	of	ADP
ctmj-149	99	16	the	the	DET
ctmj-149	99	17	bbb	bbb	PROPN
ctmj-149	99	18	permeability	permeability	NOUN
ctmj-149	99	19	mechanisms	mechanism	NOUN
ctmj-149	99	20	.	.	PUNCT
ctmj-149	100	1	such	such	ADJ
ctmj-149	100	2	desired	desire	VERB
ctmj-149	100	3	models	model	NOUN
ctmj-149	100	4	mainly	mainly	ADV
ctmj-149	100	5	include	include	VERB
ctmj-149	100	6	those	those	PRON
ctmj-149	100	7	that	that	PRON
ctmj-149	100	8	would	would	AUX
ctmj-149	100	9	predict	predict	VERB
ctmj-149	100	10	the	the	DET
ctmj-149	100	11	associated	associated	ADJ
ctmj-149	100	12	bbb	bbb	NOUN
ctmj-149	100	13	processes	process	NOUN
ctmj-149	100	14	using	use	VERB
ctmj-149	100	15	computer	computer	NOUN
ctmj-149	100	16	simulation	simulation	NOUN
ctmj-149	100	17	technology	technology	NOUN
ctmj-149	100	18	,	,	PUNCT
ctmj-149	100	19	parallel	parallel	ADJ
ctmj-149	100	20	artificial	artificial	ADJ
ctmj-149	100	21	membrane	membrane	NOUN
ctmj-149	100	22	permeability	permeability	NOUN
ctmj-149	100	23	assay	assay	NOUN
ctmj-149	100	24	(	(	PUNCT
ctmj-149	100	25	pampa	pampa	PROPN
ctmj-149	100	26	)	)	PUNCT
ctmj-149	100	27	,	,	PUNCT
ctmj-149	100	28	and	and	CCONJ
ctmj-149	100	29	in	in	ADP
ctmj-149	100	30	vitro	vitro	X
ctmj-149	100	31	cell	cell	NOUN
ctmj-149	100	32	culture	culture	NOUN
ctmj-149	100	33	techniques.6	techniques.6	PROPN
ctmj-149	100	34	cell	cell	NOUN
ctmj-149	100	35	culture	culture	NOUN
ctmj-149	100	36	is	be	AUX
ctmj-149	100	37	currently	currently	ADV
ctmj-149	100	38	the	the	DET
ctmj-149	100	39	favored	favor	VERB
ctmj-149	100	40	tool	tool	NOUN
ctmj-149	100	41	for	for	ADP
ctmj-149	100	42	simultaneously	simultaneously	ADV
ctmj-149	100	43	obtaining	obtain	VERB
ctmj-149	100	44	complex	complex	ADJ
ctmj-149	100	45	and	and	CCONJ
ctmj-149	100	46	comprehensive	comprehensive	ADJ
ctmj-149	100	47	information	information	NOUN
ctmj-149	100	48	of	of	ADP
ctmj-149	100	49	passive	passive	ADJ
ctmj-149	100	50	and	and	CCONJ
ctmj-149	100	51	active	active	ADJ
ctmj-149	100	52	transport	transport	NOUN
ctmj-149	100	53	processes	process	NOUN
ctmj-149	100	54	.	.	PUNCT
ctmj-149	101	1	generally	generally	ADV
ctmj-149	101	2	,	,	PUNCT
ctmj-149	101	3	there	there	PRON
ctmj-149	101	4	are	be	VERB
ctmj-149	101	5	two	two	NUM
ctmj-149	101	6	types	type	NOUN
ctmj-149	101	7	of	of	ADP
ctmj-149	101	8	cell	cell	NOUN
ctmj-149	101	9	culture	culture	NOUN
ctmj-149	101	10	models	model	NOUN
ctmj-149	101	11	that	that	PRON
ctmj-149	101	12	are	be	AUX
ctmj-149	101	13	used	use	VERB
ctmj-149	101	14	to	to	PART
ctmj-149	101	15	simulate	simulate	VERB
ctmj-149	101	16	the	the	DET
ctmj-149	101	17	bbb	bbb	PROPN
ctmj-149	101	18	.	.	PUNCT
ctmj-149	102	1	one	one	NUM
ctmj-149	102	2	consists	consist	VERB
ctmj-149	102	3	of	of	ADP
ctmj-149	102	4	the	the	DET
ctmj-149	102	5	“	"	PUNCT
ctmj-149	102	6	real	real	ADJ
ctmj-149	102	7	bbb	bbb	PROPN
ctmj-149	102	8	model	model	NOUN
ctmj-149	102	9	,	,	PUNCT
ctmj-149	102	10	”	"	PUNCT
ctmj-149	102	11	which	which	PRON
ctmj-149	102	12	is	be	AUX
ctmj-149	102	13	based	base	VERB
ctmj-149	102	14	on	on	ADP
ctmj-149	102	15	primary	primary	ADJ
ctmj-149	102	16	cultures	culture	NOUN
ctmj-149	102	17	of	of	ADP
ctmj-149	102	18	brain	brain	NOUN
ctmj-149	102	19	capillary	capillary	ADJ
ctmj-149	102	20	endothelial	endothelial	NOUN
ctmj-149	102	21	cells	cell	NOUN
ctmj-149	102	22	or	or	CCONJ
ctmj-149	102	23	single	single	ADJ
ctmj-149	102	24	cell	cell	NOUN
ctmj-149	102	25	lines	line	NOUN
ctmj-149	102	26	that	that	PRON
ctmj-149	102	27	may	may	AUX
ctmj-149	102	28	be	be	AUX
ctmj-149	102	29	complemented	complement	VERB
ctmj-149	102	30	or	or	CCONJ
ctmj-149	102	31	co	co	VERB
ctmj-149	102	32	-	-	VERB
ctmj-149	102	33	cultured	cultured	ADJ
ctmj-149	102	34	with	with	ADP
ctmj-149	102	35	astrocytes	astrocyte	NOUN
ctmj-149	102	36	/	/	SYM
ctmj-149	102	37	pericytes.23,24	pericytes.23,24	VERB
ctmj-149	102	38	the	the	DET
ctmj-149	102	39	other	other	ADJ
ctmj-149	102	40	type	type	NOUN
ctmj-149	102	41	is	be	AUX
ctmj-149	102	42	the	the	DET
ctmj-149	102	43	“	"	PUNCT
ctmj-149	102	44	sur	sur	PROPN
ctmj-149	102	45	rogate	rogate	NOUN
ctmj-149	102	46	bbb	bbb	PROPN
ctmj-149	102	47	model	model	NOUN
ctmj-149	102	48	,	,	PUNCT
ctmj-149	102	49	”	"	PUNCT
ctmj-149	102	50	which	which	PRON
ctmj-149	102	51	uses	use	VERB
ctmj-149	102	52	similar	similar	ADJ
ctmj-149	102	53	epithelial	epithelial	ADJ
ctmj-149	102	54	cells	cell	NOUN
ctmj-149	102	55	such	such	ADJ
ctmj-149	102	56	as	as	ADP
ctmj-149	102	57	mdck	mdck	PROPN
ctmj-149	102	58	,	,	PUNCT
ctmj-149	102	59	mdck	mdck	NOUN
ctmj-149	102	60	-	-	PUNCT
ctmj-149	102	61	mdr1,and	mdr1,and	NOUN
ctmj-149	102	62	human	human	ADJ
ctmj-149	102	63	colon	colon	NOUN
ctmj-149	102	64	carcinoma	carcinoma	NOUN
ctmj-149	102	65	cell	cell	NOUN
ctmj-149	102	66	lines	line	NOUN
ctmj-149	102	67	(	(	PUNCT
ctmj-149	102	68	caco-2).5,25,26	caco-2).5,25,26	X
ctmj-149	102	69	among	among	ADP
ctmj-149	102	70	these	these	PRON
ctmj-149	102	71	,	,	PUNCT
ctmj-149	102	72	mdck	mdck	PROPN
ctmj-149	102	73	and	and	CCONJ
ctmj-149	102	74	mdckmdr1	mdckmdr1	NOUN
ctmj-149	102	75	have	have	AUX
ctmj-149	102	76	been	be	AUX
ctmj-149	102	77	recognized	recognize	VERB
ctmj-149	102	78	as	as	ADP
ctmj-149	102	79	the	the	DET
ctmj-149	102	80	ideal	ideal	ADJ
ctmj-149	102	81	models	model	NOUN
ctmj-149	102	82	for	for	ADP
ctmj-149	102	83	in	in	ADP
ctmj-149	102	84	vitro	vitro	X
ctmj-149	102	85	simulation	simulation	NOUN
ctmj-149	102	86	of	of	ADP
ctmj-149	102	87	bbb	bbb	PROPN
ctmj-149	102	88	drug	drug	NOUN
ctmj-149	102	89	penetration.6,27e29	penetration.6,27e29	PROPN
ctmj-149	102	90	they	they	PRON
ctmj-149	102	91	have	have	VERB
ctmj-149	102	92	several	several	ADJ
ctmj-149	102	93	advantages	advantage	NOUN
ctmj-149	102	94	including	include	VERB
ctmj-149	102	95	(	(	PUNCT
ctmj-149	102	96	1	1	NUM
ctmj-149	102	97	)	)	PUNCT
ctmj-149	102	98	stable	stable	ADJ
ctmj-149	102	99	source	source	NOUN
ctmj-149	102	100	with	with	ADP
ctmj-149	102	101	no	no	DET
ctmj-149	102	102	batch	batch	NOUN
ctmj-149	102	103	-	-	PUNCT
ctmj-149	102	104	to	to	ADP
ctmj-149	102	105	-	-	PUNCT
ctmj-149	102	106	batch	batch	NOUN
ctmj-149	102	107	variability	variability	NOUN
ctmj-149	102	108	,	,	PUNCT
ctmj-149	102	109	(	(	PUNCT
ctmj-149	102	110	2	2	X
ctmj-149	102	111	)	)	PUNCT
ctmj-149	102	112	convenient	convenient	ADJ
ctmj-149	102	113	for	for	ADP
ctmj-149	102	114	routine	routine	ADJ
ctmj-149	102	115	experimental	experimental	ADJ
ctmj-149	102	116	application	application	NOUN
ctmj-149	102	117	and	and	CCONJ
ctmj-149	102	118	thus	thus	ADV
ctmj-149	102	119	reduce	reduce	VERB
ctmj-149	102	120	labor	labor	NOUN
ctmj-149	102	121	intensity	intensity	NOUN
ctmj-149	102	122	,	,	PUNCT
ctmj-149	102	123	(	(	PUNCT
ctmj-149	102	124	3	3	X
ctmj-149	102	125	)	)	PUNCT
ctmj-149	102	126	adequately	adequately	ADV
ctmj-149	102	127	and	and	CCONJ
ctmj-149	102	128	closely	closely	ADV
ctmj-149	102	129	mimic	mimic	VERB
ctmj-149	102	130	relevant	relevant	ADJ
ctmj-149	102	131	in	in	ADP
ctmj-149	102	132	vivo	vivo	ADJ
ctmj-149	102	133	properties	property	NOUN
ctmj-149	102	134	of	of	ADP
ctmj-149	102	135	the	the	DET
ctmj-149	102	136	bbb	bbb	PROPN
ctmj-149	102	137	,	,	PUNCT
ctmj-149	102	138	(	(	PUNCT
ctmj-149	102	139	4	4	X
ctmj-149	102	140	)	)	PUNCT
ctmj-149	102	141	ensure	ensure	VERB
ctmj-149	102	142	adequate	adequate	ADJ
ctmj-149	102	143	monolayer	monolayer	NOUN
ctmj-149	102	144	integrity	integrity	NOUN
ctmj-149	102	145	and	and	CCONJ
ctmj-149	102	146	display	display	VERB
ctmj-149	102	147	a	a	DET
ctmj-149	102	148	proper	proper	ADJ
ctmj-149	102	149	teer	teer	NOUN
ctmj-149	102	150	value	value	NOUN
ctmj-149	102	151	under	under	ADP
ctmj-149	102	152	conventional	conventional	ADJ
ctmj-149	102	153	experimental	experimental	ADJ
ctmj-149	102	154	conditions	condition	NOUN
ctmj-149	102	155	,	,	PUNCT
ctmj-149	102	156	and	and	CCONJ
ctmj-149	102	157	(	(	PUNCT
ctmj-149	102	158	5	5	X
ctmj-149	102	159	)	)	PUNCT
ctmj-149	102	160	show	show	VERB
ctmj-149	102	161	superior	superior	ADJ
ctmj-149	102	162	p	p	NOUN
ctmj-149	102	163	-	-	PUNCT
ctmj-149	102	164	glycoprotein	glycoprotein	NOUN
ctmj-149	102	165	(	(	PUNCT
ctmj-149	102	166	p	p	NOUN
ctmj-149	102	167	-	-	PUNCT
ctmj-149	102	168	gp	gp	NOUN
ctmj-149	102	169	)	)	PUNCT
ctmj-149	102	170	expression	expression	NOUN
ctmj-149	102	171	and	and	CCONJ
ctmj-149	102	172	activity	activity	NOUN
ctmj-149	102	173	,	,	PUNCT
ctmj-149	102	174	particularly	particularly	ADV
ctmj-149	102	175	in	in	ADP
ctmj-149	102	176	mdck	mdck	PROPN
ctmj-149	102	177	-	-	PUNCT
ctmj-149	102	178	mdr1	mdr1	PROPN
ctmj-149	102	179	cells	cell	NOUN
ctmj-149	102	180	transfected	transfecte	VERB
ctmj-149	102	181	with	with	ADP
ctmj-149	102	182	the	the	DET
ctmj-149	102	183	human	human	ADJ
ctmj-149	102	184	mdr1	mdr1	PROPN
ctmj-149	102	185	gene	gene	NOUN
ctmj-149	102	186	,	,	PUNCT
ctmj-149	102	187	which	which	PRON
ctmj-149	102	188	is	be	AUX
ctmj-149	102	189	a	a	DET
ctmj-149	102	190	very	very	ADV
ctmj-149	102	191	important	important	ADJ
ctmj-149	102	192	efflux	efflux	NOUN
ctmj-149	102	193	transporter	transporter	NOUN
ctmj-149	102	194	in	in	ADP
ctmj-149	102	195	the	the	DET
ctmj-149	102	196	bbb.30e34	bbb.30e34	NOUN
ctmj-149	102	197	therefore	therefore	ADV
ctmj-149	102	198	,	,	PUNCT
ctmj-149	102	199	we	we	PRON
ctmj-149	102	200	chose	choose	VERB
ctmj-149	102	201	mdck	mdck	PROPN
ctmj-149	102	202	and	and	CCONJ
ctmj-149	102	203	mdr1	mdr1	PROPN
ctmj-149	102	204	-	-	PUNCT
ctmj-149	102	205	mdck	mdck	PROPN
ctmj-149	102	206	cells	cell	NOUN
ctmj-149	102	207	to	to	PART
ctmj-149	102	208	establish	establish	VERB
ctmj-149	102	209	our	our	PRON
ctmj-149	102	210	in	in	X
ctmj-149	102	211	vitro	vitro	X
ctmj-149	102	212	bbb	bbb	PROPN
ctmj-149	102	213	model	model	NOUN
ctmj-149	102	214	.	.	PUNCT
ctmj-149	103	1	drugs	drug	NOUN
ctmj-149	103	2	cross	cross	VERB
ctmj-149	103	3	the	the	DET
ctmj-149	103	4	blood	blood	NOUN
ctmj-149	103	5	brain	brain	NOUN
ctmj-149	103	6	barrier	barrier	NOUN
ctmj-149	103	7	by	by	ADP
ctmj-149	103	8	two	two	NUM
ctmj-149	103	9	main	main	ADJ
ctmj-149	103	10	methods	method	NOUN
ctmj-149	103	11	:	:	PUNCT
ctmj-149	103	12	transcellular	transcellular	NOUN
ctmj-149	103	13	and	and	CCONJ
ctmj-149	103	14	paracellular	paracellular	ADJ
ctmj-149	103	15	transport	transport	NOUN
ctmj-149	103	16	.	.	PUNCT
ctmj-149	104	1	in	in	ADP
ctmj-149	104	2	addition	addition	NOUN
ctmj-149	104	3	,	,	PUNCT
ctmj-149	104	4	numerous	numerous	ADJ
ctmj-149	104	5	elements	element	NOUN
ctmj-149	104	6	impede	impede	VERB
ctmj-149	104	7	penetration	penetration	NOUN
ctmj-149	104	8	of	of	ADP
ctmj-149	104	9	drugs	drug	NOUN
ctmj-149	104	10	and	and	CCONJ
ctmj-149	104	11	substances	substance	NOUN
ctmj-149	104	12	from	from	ADP
ctmj-149	104	13	the	the	DET
ctmj-149	104	14	extra	extra	ADJ
ctmj-149	104	15	-	-	PUNCT
ctmj-149	104	16	brain	brain	ADJ
ctmj-149	104	17	region	region	NOUN
ctmj-149	104	18	to	to	ADP
ctmj-149	104	19	the	the	DET
ctmj-149	104	20	brain	brain	NOUN
ctmj-149	104	21	area	area	NOUN
ctmj-149	104	22	,	,	PUNCT
ctmj-149	104	23	including	include	VERB
ctmj-149	104	24	the	the	DET
ctmj-149	104	25	bbb	bbb	PROPN
ctmj-149	104	26	morphologic	morphologic	ADJ
ctmj-149	104	27	characteristics	characteristic	NOUN
ctmj-149	104	28	(	(	PUNCT
ctmj-149	104	29	such	such	ADJ
ctmj-149	104	30	as	as	ADP
ctmj-149	104	31	fig	fig	NOUN
ctmj-149	104	32	.	.	PUNCT
ctmj-149	105	1	3	3	NUM
ctmj-149	105	2	change	change	NOUN
ctmj-149	105	3	in	in	ADP
ctmj-149	105	4	transepithelial	transepithelial	ADJ
ctmj-149	105	5	electrical	electrical	ADJ
ctmj-149	105	6	resistance	resistance	NOUN
ctmj-149	105	7	(	(	PUNCT
ctmj-149	105	8	teer	teer	NOUN
ctmj-149	105	9	)	)	PUNCT
ctmj-149	105	10	in	in	ADP
ctmj-149	105	11	(	(	PUNCT
ctmj-149	105	12	a	a	PRON
ctmj-149	105	13	,	,	PUNCT
ctmj-149	105	14	b	b	NOUN
ctmj-149	105	15	)	)	PUNCT
ctmj-149	105	16	madinedarby	madinedarby	NOUN
ctmj-149	105	17	canine	canine	NOUN
ctmj-149	105	18	kidney	kidney	PROPN
ctmj-149	105	19	(	(	PUNCT
ctmj-149	105	20	mdck	mdck	NOUN
ctmj-149	105	21	)	)	PUNCT
ctmj-149	105	22	epithelial	epithelial	ADJ
ctmj-149	105	23	and	and	CCONJ
ctmj-149	105	24	(	(	PUNCT
ctmj-149	105	25	c	c	X
ctmj-149	105	26	,	,	PUNCT
ctmj-149	105	27	d	d	NOUN
ctmj-149	105	28	)	)	PUNCT
ctmj-149	105	29	mdck	mdck	PROPN
ctmj-149	105	30	multi	multi	ADJ
ctmj-149	105	31	-	-	ADJ
ctmj-149	105	32	drug	drug	ADJ
ctmj-149	105	33	resistance	resistance	NOUN
ctmj-149	105	34	1	1	NUM
ctmj-149	105	35	(	(	PUNCT
ctmj-149	105	36	mdck	mdck	PROPN
ctmj-149	105	37	-	-	PUNCT
ctmj-149	105	38	mdr1	mdr1	PROPN
ctmj-149	105	39	)	)	PUNCT
ctmj-149	105	40	cells	cell	NOUN
ctmj-149	105	41	after	after	ADP
ctmj-149	105	42	treatment	treatment	NOUN
ctmj-149	105	43	with	with	ADP
ctmj-149	105	44	different	different	ADJ
ctmj-149	105	45	compounds	compound	NOUN
ctmj-149	105	46	.	.	PUNCT
ctmj-149	106	1	(	(	PUNCT
ctmj-149	106	2	a	a	PRON
ctmj-149	106	3	,	,	PUNCT
ctmj-149	106	4	b	b	NOUN
ctmj-149	106	5	)	)	PUNCT
ctmj-149	106	6	teer	teer	NOUN
ctmj-149	106	7	of	of	ADP
ctmj-149	106	8	mdck	mdck	PROPN
ctmj-149	106	9	cells	cell	NOUN
ctmj-149	106	10	gradually	gradually	ADV
ctmj-149	106	11	decreased	decrease	VERB
ctmj-149	106	12	following	follow	VERB
ctmj-149	106	13	treatment	treatment	NOUN
ctmj-149	106	14	with	with	ADP
ctmj-149	106	15	compounds	compound	NOUN
ctmj-149	106	16	alone	alone	ADJ
ctmj-149	106	17	or	or	CCONJ
ctmj-149	106	18	in	in	ADP
ctmj-149	106	19	combination	combination	NOUN
ctmj-149	106	20	with	with	ADP
ctmj-149	106	21	menthol	menthol	NOUN
ctmj-149	106	22	.	.	PUNCT
ctmj-149	107	1	(	(	PUNCT
ctmj-149	107	2	c	c	X
ctmj-149	107	3	,	,	PUNCT
ctmj-149	107	4	d	d	NOUN
ctmj-149	107	5	)	)	PUNCT
ctmj-149	107	6	teer	teer	NOUN
ctmj-149	107	7	in	in	ADP
ctmj-149	107	8	menthol	menthol	NOUN
ctmj-149	107	9	-	-	PUNCT
ctmj-149	107	10	treated	treat	VERB
ctmj-149	107	11	mdck	mdck	PROPN
ctmj-149	107	12	-	-	PUNCT
ctmj-149	107	13	mdr1	mdr1	PROPN
ctmj-149	107	14	cells	cell	NOUN
ctmj-149	107	15	similarly	similarly	ADV
ctmj-149	107	16	declined	decline	VERB
ctmj-149	107	17	.	.	PUNCT
ctmj-149	108	1	data	datum	NOUN
ctmj-149	108	2	presented	present	VERB
ctmj-149	108	3	as	as	ADP
ctmj-149	108	4	mean	mean	NOUN
ctmj-149	108	5	(	(	PUNCT
ctmj-149	108	6	sd	sd	NOUN
ctmj-149	108	7	)	)	PUNCT
ctmj-149	108	8	(	(	PUNCT
ctmj-149	108	9	n	n	NOUN
ctmj-149	108	10	z	z	NOUN
ctmj-149	108	11	3	3	NUM
ctmj-149	108	12	)	)	PUNCT
ctmj-149	108	13	.	.	PUNCT
ctmj-149	109	1	pp	pp	ADV
ctmj-149	109	2	:	:	PUNCT
ctmj-149	109	3	puerarin	puerarin	NOUN
ctmj-149	109	4	and	and	CCONJ
ctmj-149	109	5	paeoniflorin	paeoniflorin	NOUN
ctmj-149	109	6	;	;	PUNCT
ctmj-149	109	7	pm	pm	NOUN
ctmj-149	109	8	:	:	PUNCT
ctmj-149	109	9	puerarin	puerarin	NOUN
ctmj-149	109	10	and	and	CCONJ
ctmj-149	109	11	menthol	menthol	NOUN
ctmj-149	109	12	;	;	PUNCT
ctmj-149	109	13	ppm	ppm	NUM
ctmj-149	109	14	:	:	PUNCT
ctmj-149	109	15	puerarin	puerarin	NOUN
ctmj-149	109	16	,	,	PUNCT
ctmj-149	109	17	paeoniflorin	paeoniflorin	NOUN
ctmj-149	109	18	and	and	CCONJ
ctmj-149	109	19	menthol	menthol	NOUN
ctmj-149	109	20	groups	group	NOUN
ctmj-149	109	21	.	.	PUNCT
ctmj-149	110	1	existence	existence	NOUN
ctmj-149	110	2	of	of	ADP
ctmj-149	110	3	tjs	tjs	NOUN
ctmj-149	110	4	)	)	PUNCT
ctmj-149	110	5	,	,	PUNCT
ctmj-149	110	6	enzymes	enzyme	NOUN
ctmj-149	110	7	in	in	ADP
ctmj-149	110	8	the	the	DET
ctmj-149	110	9	cytosolor	cytosolor	NOUN
ctmj-149	110	10	on	on	ADP
ctmj-149	110	11	the	the	DET
ctmj-149	110	12	extra	extra	ADJ
ctmj-149	110	13	cellular	cellular	ADJ
ctmj-149	110	14	membrane	membrane	NOUN
ctmj-149	110	15	,	,	PUNCT
ctmj-149	110	16	and	and	CCONJ
ctmj-149	110	17	p	p	X
ctmj-149	110	18	-	-	PUNCT
ctmj-149	110	19	glycoprotein	glycoprotein	NOUN
ctmj-149	110	20	(	(	PUNCT
ctmj-149	110	21	p	p	NOUN
ctmj-149	110	22	-	-	PUNCT
ctmj-149	110	23	gp	gp	NOUN
ctmj-149	110	24	)	)	PUNCT
ctmj-149	110	25	.	.	PUNCT
ctmj-149	111	1	for	for	ADP
ctmj-149	111	2	hydrophilous	hydrophilous	ADJ
ctmj-149	111	3	compounds	compound	NOUN
ctmj-149	111	4	,	,	PUNCT
ctmj-149	111	5	paracellular	paracellular	ADJ
ctmj-149	111	6	transport	transport	NOUN
ctmj-149	111	7	is	be	AUX
ctmj-149	111	8	a	a	DET
ctmj-149	111	9	crucial	crucial	ADJ
ctmj-149	111	10	pathway	pathway	NOUN
ctmj-149	111	11	for	for	ADP
ctmj-149	111	12	penetrating	penetrate	VERB
ctmj-149	111	13	the	the	DET
ctmj-149	111	14	brain	brain	NOUN
ctmj-149	111	15	and	and	CCONJ
ctmj-149	111	16	exerting	exert	VERB
ctmj-149	111	17	a	a	DET
ctmj-149	111	18	therapeutic	therapeutic	ADJ
ctmj-149	111	19	effect	effect	NOUN
ctmj-149	111	20	.	.	PUNCT
ctmj-149	112	1	the	the	DET
ctmj-149	112	2	physiologic	physiologic	ADJ
ctmj-149	112	3	function	function	NOUN
ctmj-149	112	4	of	of	ADP
ctmj-149	112	5	the	the	DET
ctmj-149	112	6	tj	tj	NOUN
ctmj-149	112	7	is	be	AUX
ctmj-149	112	8	inseparable	inseparable	ADJ
ctmj-149	112	9	from	from	ADP
ctmj-149	112	10	paracellular	paracellular	ADJ
ctmj-149	112	11	transport	transport	NOUN
ctmj-149	112	12	and	and	CCONJ
ctmj-149	112	13	its	its	PRON
ctmj-149	112	14	barrier	barrier	NOUN
ctmj-149	112	15	and	and	CCONJ
ctmj-149	112	16	fence	fence	NOUN
ctmj-149	112	17	functions	function	NOUN
ctmj-149	112	18	are	be	AUX
ctmj-149	112	19	regulated	regulate	VERB
ctmj-149	112	20	by	by	ADP
ctmj-149	112	21	various	various	ADJ
ctmj-149	112	22	factors.35e37	factors.35e37	NOUN
ctmj-149	112	23	using	use	VERB
ctmj-149	112	24	on	on	ADP
ctmj-149	112	25	the	the	DET
ctmj-149	112	26	simulated	simulate	VERB
ctmj-149	112	27	bbb	bbb	PROPN
ctmj-149	112	28	mdck	mdck	PROPN
ctmj-149	112	29	and	and	CCONJ
ctmj-149	112	30	mdck	mdck	PROPN
ctmj-149	112	31	-	-	PUNCT
ctmj-149	112	32	mdr1	mdr1	PROPN
ctmj-149	112	33	cell	cell	NOUN
ctmj-149	112	34	model	model	NOUN
ctmj-149	112	35	,	,	PUNCT
ctmj-149	112	36	we	we	PRON
ctmj-149	112	37	focused	focus	VERB
ctmj-149	112	38	on	on	ADP
ctmj-149	112	39	studying	study	VERB
ctmj-149	112	40	the	the	DET
ctmj-149	112	41	mechanism	mechanism	NOUN
ctmj-149	112	42	of	of	ADP
ctmj-149	112	43	the	the	DET
ctmj-149	112	44	main	main	ADJ
ctmj-149	112	45	active	active	ADJ
ctmj-149	112	46	constituents	constituent	NOUN
ctmj-149	112	47	in	in	ADP
ctmj-149	112	48	the	the	DET
ctmj-149	112	49	tongqiaosanyu	tongqiaosanyu	NOUN
ctmj-149	112	50	prescription	prescription	NOUN
ctmj-149	112	51	to	to	PART
ctmj-149	112	52	determine	determine	VERB
ctmj-149	112	53	their	their	PRON
ctmj-149	112	54	effects	effect	NOUN
ctmj-149	112	55	on	on	ADP
ctmj-149	112	56	the	the	DET
ctmj-149	112	57	structure	structure	NOUN
ctmj-149	112	58	and	and	CCONJ
ctmj-149	112	59	barrier	barrier	NOUN
ctmj-149	112	60	function	function	NOUN
ctmj-149	112	61	of	of	ADP
ctmj-149	112	62	tjs	tjs	NOUN
ctmj-149	112	63	.	.	PUNCT
ctmj-149	113	1	the	the	DET
ctmj-149	113	2	tj	tj	NOUN
ctmj-149	113	3	structure	structure	NOUN
ctmj-149	113	4	is	be	AUX
ctmj-149	113	5	composed	compose	VERB
ctmj-149	113	6	of	of	ADP
ctmj-149	113	7	various	various	ADJ
ctmj-149	113	8	types	type	NOUN
ctmj-149	113	9	of	of	ADP
ctmj-149	113	10	proteins	protein	NOUN
ctmj-149	113	11	and	and	CCONJ
ctmj-149	113	12	occludin	occludin	NOUN
ctmj-149	113	13	is	be	AUX
ctmj-149	113	14	regarded	regard	VERB
ctmj-149	113	15	as	as	ADP
ctmj-149	113	16	the	the	DET
ctmj-149	113	17	primary	primary	ADJ
ctmj-149	113	18	identifying	identify	VERB
ctmj-149	113	19	molecule	molecule	NOUN
ctmj-149	113	20	of	of	ADP
ctmj-149	113	21	the	the	DET
ctmj-149	113	22	tj	tj	NOUN
ctmj-149	113	23	strands	strand	NOUN
ctmj-149	113	24	.	.	PUNCT
ctmj-149	114	1	it	it	PRON
ctmj-149	114	2	is	be	AUX
ctmj-149	114	3	a	a	DET
ctmj-149	114	4	tetraspan	tetraspan	NOUN
ctmj-149	114	5	membrane	membrane	NOUN
ctmj-149	114	6	protein	protein	NOUN
ctmj-149	114	7	of	of	ADP
ctmj-149	114	8	approximately	approximately	ADV
ctmj-149	114	9	60	60	NUM
ctmj-149	114	10	-	-	PUNCT
ctmj-149	114	11	kd	kd	NOUN
ctmj-149	114	12	,	,	PUNCT
ctmj-149	114	13	with	with	ADP
ctmj-149	114	14	a	a	DET
ctmj-149	114	15	short	short	ADJ
ctmj-149	114	16	intracellular	intracellular	ADJ
ctmj-149	114	17	curve	curve	NOUN
ctmj-149	114	18	,	,	PUNCT
ctmj-149	114	19	two	two	NUM
ctmj-149	114	20	extracellular	extracellular	ADJ
ctmj-149	114	21	annuli	annulus	NOUN
ctmj-149	114	22	,	,	PUNCT
ctmj-149	114	23	and	and	CCONJ
ctmj-149	114	24	nand	nand	VERB
ctmj-149	114	25	c	c	NOUN
ctmj-149	114	26	-	-	PUNCT
ctmj-149	114	27	terminals	terminal	NOUN
ctmj-149	114	28	in	in	ADP
ctmj-149	114	29	the	the	DET
ctmj-149	114	30	cytoplasmic	cytoplasmic	ADJ
ctmj-149	114	31	domain.38	domain.38	NOUN
ctmj-149	114	32	assembly	assembly	NOUN
ctmj-149	114	33	of	of	ADP
ctmj-149	114	34	tjs	tjs	NOUN
ctmj-149	114	35	and	and	CCONJ
ctmj-149	114	36	concomitant	concomitant	ADJ
ctmj-149	114	37	increase	increase	NOUN
ctmj-149	114	38	in	in	ADP
ctmj-149	114	39	teer	teer	NOUN
ctmj-149	114	40	have	have	AUX
ctmj-149	114	41	been	be	AUX
ctmj-149	114	42	demonstrated	demonstrate	VERB
ctmj-149	114	43	to	to	PART
ctmj-149	114	44	be	be	AUX
ctmj-149	114	45	associated	associate	VERB
ctmj-149	114	46	with	with	ADP
ctmj-149	114	47	tyrosine	tyrosine	NOUN
ctmj-149	114	48	phosphorylation	phosphorylation	NOUN
ctmj-149	114	49	of	of	ADP
ctmj-149	114	50	occludin	occludin	PROPN
ctmj-149	114	51	,	,	PUNCT
ctmj-149	114	52	which	which	PRON
ctmj-149	114	53	is	be	AUX
ctmj-149	114	54	a	a	DET
ctmj-149	114	55	phenomenon	phenomenon	NOUN
ctmj-149	114	56	commonly	commonly	ADV
ctmj-149	114	57	observed	observe	VERB
ctmj-149	114	58	after	after	ADP
ctmj-149	114	59	recovery	recovery	NOUN
ctmj-149	114	60	from	from	ADP
ctmj-149	114	61	adenosine	adenosine	ADJ
ctmj-149	114	62	triphosphate	triphosphate	NOUN
ctmj-149	114	63	(	(	PUNCT
ctmj-149	114	64	atp	atp	NOUN
ctmj-149	114	65	)	)	PUNCT
ctmj-149	114	66	depletion	depletion	NOUN
ctmj-149	114	67	or	or	CCONJ
ctmj-149	114	68	during	during	ADP
ctmj-149	114	69	calcium	calcium	NOUN
ctmj-149	114	70	repletion.39,40	repletion.39,40	NOUN
ctmj-149	114	71	claudins	claudin	NOUN
ctmj-149	114	72	have	have	VERB
ctmj-149	114	73	different	different	ADJ
ctmj-149	114	74	sequences	sequence	NOUN
ctmj-149	114	75	from	from	ADP
ctmj-149	114	76	occluding	occlude	VERB
ctmj-149	114	77	and	and	CCONJ
ctmj-149	114	78	are	be	AUX
ctmj-149	114	79	18to	18to	ADJ
ctmj-149	114	80	27	27	NUM
ctmj-149	114	81	-	-	PUNCT
ctmj-149	114	82	kdtetraspan	kdtetraspan	NOUN
ctmj-149	114	83	proteins	protein	NOUN
ctmj-149	114	84	with	with	ADP
ctmj-149	114	85	two	two	NUM
ctmj-149	114	86	extracellular	extracellular	ADJ
ctmj-149	114	87	annuli	annulus	NOUN
ctmj-149	114	88	,	,	PUNCT
ctmj-149	114	89	a	a	DET
ctmj-149	114	90	short	short	ADJ
ctmj-149	114	91	n	n	CCONJ
ctmj-149	114	92	-	-	PUNCT
ctmj-149	114	93	terminus	terminus	NOUN
ctmj-149	114	94	,	,	PUNCT
ctmj-149	114	95	and	and	CCONJ
ctmj-149	114	96	a	a	DET
ctmj-149	114	97	cterminal	cterminal	NOUN
ctmj-149	114	98	in	in	ADP
ctmj-149	114	99	the	the	DET
ctmj-149	114	100	cytoplasmic	cytoplasmic	ADJ
ctmj-149	114	101	domain.41	domain.41	NOUN
ctmj-149	114	102	claudin-1	claudin-1	NUM
ctmj-149	114	103	is	be	AUX
ctmj-149	114	104	also	also	ADV
ctmj-149	114	105	considered	consider	VERB
ctmj-149	114	106	an	an	DET
ctmj-149	114	107	important	important	ADJ
ctmj-149	114	108	strand	strand	NOUN
ctmj-149	114	109	or	or	CCONJ
ctmj-149	114	110	even	even	ADV
ctmj-149	114	111	the	the	DET
ctmj-149	114	112	back	back	ADJ
ctmj-149	114	113	bone	bone	NOUN
ctmj-149	114	114	of	of	ADP
ctmj-149	114	115	tjs.42	tjs.42	DET
ctmj-149	114	116	recent	recent	ADJ
ctmj-149	114	117	studies	study	NOUN
ctmj-149	114	118	have	have	AUX
ctmj-149	114	119	shown	show	VERB
ctmj-149	114	120	that	that	SCONJ
ctmj-149	114	121	claudin-1	claudin-1	PROPN
ctmj-149	114	122	is	be	AUX
ctmj-149	114	123	the	the	DET
ctmj-149	114	124	decisive	decisive	ADJ
ctmj-149	114	125	component	component	NOUN
ctmj-149	114	126	of	of	ADP
ctmj-149	114	127	tjs	tjs	NOUN
ctmj-149	114	128	and	and	CCONJ
ctmj-149	114	129	possesses	possess	VERB
ctmj-149	114	130	cell	cell	NOUN
ctmj-149	114	131	adhesion	adhesion	NOUN
ctmj-149	114	132	activity.43	activity.43	VERB
ctmj-149	114	133	it	it	PRON
ctmj-149	114	134	can	can	AUX
ctmj-149	114	135	directly	directly	ADV
ctmj-149	114	136	affect	affect	VERB
ctmj-149	114	137	the	the	DET
ctmj-149	114	138	regulation	regulation	NOUN
ctmj-149	114	139	of	of	ADP
ctmj-149	114	140	paracellular	paracellular	ADJ
ctmj-149	114	141	transport	transport	NOUN
ctmj-149	114	142	and	and	CCONJ
ctmj-149	114	143	the	the	DET
ctmj-149	114	144	selectivity	selectivity	NOUN
ctmj-149	114	145	of	of	ADP
ctmj-149	114	146	solute	solute	ADJ
ctmj-149	114	147	size	size	NOUN
ctmj-149	114	148	.	.	PUNCT
ctmj-149	115	1	f	f	X
ctmj-149	115	2	-	-	PUNCT
ctmj-149	115	3	actin	actin	NOUN
ctmj-149	115	4	,	,	PUNCT
ctmj-149	115	5	which	which	PRON
ctmj-149	115	6	is	be	AUX
ctmj-149	115	7	one	one	NUM
ctmj-149	115	8	of	of	ADP
ctmj-149	115	9	the	the	DET
ctmj-149	115	10	peripheral	peripheral	ADJ
ctmj-149	115	11	membrane	membrane	NOUN
ctmj-149	115	12	proteins	protein	NOUN
ctmj-149	115	13	of	of	ADP
ctmj-149	115	14	tjs	tjs	NOUN
ctmj-149	115	15	,	,	PUNCT
ctmj-149	115	16	is	be	AUX
ctmj-149	115	17	related	relate	VERB
ctmj-149	115	18	to	to	ADP
ctmj-149	115	19	organelle	organelle	NOUN
ctmj-149	115	20	movement	movement	NOUN
ctmj-149	115	21	,	,	PUNCT
ctmj-149	115	22	protoplasmic	protoplasmic	ADJ
ctmj-149	115	23	streaming	streaming	NOUN
ctmj-149	115	24	,	,	PUNCT
ctmj-149	115	25	and	and	CCONJ
ctmj-149	115	26	intercellular	intercellular	ADJ
ctmj-149	115	27	junctionregulation.7,44e47	junctionregulation.7,44e47	PROPN
ctmj-149	115	28	importantly	importantly	ADV
ctmj-149	115	29	,	,	PUNCT
ctmj-149	115	30	the	the	DET
ctmj-149	115	31	f	f	PROPN
ctmj-149	115	32	-	-	PUNCT
ctmj-149	115	33	actin	actin	NOUN
ctmj-149	115	34	belt	belt	NOUN
ctmj-149	115	35	can	can	AUX
ctmj-149	115	36	control	control	VERB
ctmj-149	115	37	tj	tj	NOUN
ctmj-149	115	38	function	function	NOUN
ctmj-149	115	39	and	and	CCONJ
ctmj-149	115	40	limit	limit	VERB
ctmj-149	115	41	the	the	DET
ctmj-149	115	42	material	material	NOUN
ctmj-149	115	43	intake.48	intake.48	NOUN
ctmj-149	115	44	although	although	SCONJ
ctmj-149	115	45	we	we	PRON
ctmj-149	115	46	did	do	AUX
ctmj-149	115	47	not	not	PART
ctmj-149	115	48	investigate	investigate	VERB
ctmj-149	115	49	all	all	DET
ctmj-149	115	50	tj	tj	NOUN
ctmj-149	115	51	protein	protein	NOUN
ctmj-149	115	52	types	type	NOUN
ctmj-149	115	53	in	in	ADP
ctmj-149	115	54	mdck	mdck	PROPN
ctmj-149	115	55	and	and	CCONJ
ctmj-149	115	56	mdck	mdck	PROPN
ctmj-149	115	57	-	-	PUNCT
ctmj-149	115	58	mdr1	mdr1	PROPN
ctmj-149	115	59	cells	cell	NOUN
ctmj-149	115	60	,	,	PUNCT
ctmj-149	115	61	the	the	DET
ctmj-149	115	62	proteins	protein	NOUN
ctmj-149	115	63	we	we	PRON
ctmj-149	115	64	chose	choose	VERB
ctmj-149	115	65	were	be	AUX
ctmj-149	115	66	excellent	excellent	ADJ
ctmj-149	115	67	representations	representation	NOUN
ctmj-149	115	68	.	.	PUNCT
ctmj-149	116	1	we	we	PRON
ctmj-149	116	2	individually	individually	ADV
ctmj-149	116	3	analyzed	analyze	VERB
ctmj-149	116	4	the	the	DET
ctmj-149	116	5	immunofluorescence	immunofluorescence	NOUN
ctmj-149	116	6	staining	stain	VERB
ctmj-149	116	7	of	of	ADP
ctmj-149	116	8	occludin	occludin	NOUN
ctmj-149	116	9	,	,	PUNCT
ctmj-149	116	10	claudin-1	claudin-1	PROPN
ctmj-149	116	11	,	,	PUNCT
ctmj-149	116	12	and	and	CCONJ
ctmj-149	116	13	factin	factin	NOUN
ctmj-149	116	14	in	in	ADP
ctmj-149	116	15	mdck	mdck	PROPN
ctmj-149	116	16	and	and	CCONJ
ctmj-149	116	17	mdck	mdck	PROPN
ctmj-149	116	18	-	-	PUNCT
ctmj-149	116	19	mdr1	mdr1	PROPN
ctmj-149	116	20	cells	cell	NOUN
ctmj-149	116	21	after	after	ADP
ctmj-149	116	22	treatment	treatment	NOUN
ctmj-149	116	23	with	with	ADP
ctmj-149	116	24	puerarin	puerarin	NOUN
ctmj-149	116	25	,	,	PUNCT
ctmj-149	116	26	paeoniflorin	paeoniflorin	NOUN
ctmj-149	116	27	,	,	PUNCT
ctmj-149	116	28	or	or	CCONJ
ctmj-149	116	29	menthol	menthol	NOUN
ctmj-149	116	30	.	.	PUNCT
ctmj-149	117	1	the	the	DET
ctmj-149	117	2	puerarin	puerarin	NOUN
ctmj-149	117	3	and	and	CCONJ
ctmj-149	117	4	paeoniflorin	paeoniflorin	NOUN
ctmj-149	117	5	group	group	NOUN
ctmj-149	117	6	did	do	AUX
ctmj-149	117	7	not	not	PART
ctmj-149	117	8	affect	affect	VERB
ctmj-149	117	9	the	the	DET
ctmj-149	117	10	staining	stain	VERB
ctmj-149	117	11	properties	property	NOUN
ctmj-149	117	12	of	of	ADP
ctmj-149	117	13	tj	tj	NOUN
ctmj-149	117	14	proteins	protein	NOUN
ctmj-149	117	15	.	.	PUNCT
ctmj-149	118	1	only	only	ADV
ctmj-149	118	2	menthol	menthol	NOUN
ctmj-149	118	3	inhibited	inhibit	VERB
ctmj-149	118	4	the	the	DET
ctmj-149	118	5	expression	expression	NOUN
ctmj-149	118	6	and	and	CCONJ
ctmj-149	118	7	reduced	reduce	VERB
ctmj-149	118	8	the	the	DET
ctmj-149	118	9	fluorescence	fluorescence	NOUN
ctmj-149	118	10	intensity	intensity	NOUN
ctmj-149	118	11	(	(	PUNCT
ctmj-149	118	12	aod	aod	PROPN
ctmj-149	118	13	value	value	NOUN
ctmj-149	118	14	)	)	PUNCT
ctmj-149	118	15	of	of	ADP
ctmj-149	118	16	all	all	DET
ctmj-149	118	17	three	three	NUM
ctmj-149	118	18	kinds	kind	NOUN
ctmj-149	118	19	of	of	ADP
ctmj-149	118	20	tj	tj	NOUN
ctmj-149	118	21	proteins	protein	NOUN
ctmj-149	118	22	.	.	PUNCT
ctmj-149	119	1	this	this	DET
ctmj-149	119	2	characteristic	characteristic	NOUN
ctmj-149	119	3	of	of	ADP
ctmj-149	119	4	menthol	menthol	NOUN
ctmj-149	119	5	indi	indi	PROPN
ctmj-149	119	6	cated	cat	VERB
ctmj-149	119	7	that	that	SCONJ
ctmj-149	119	8	it	it	PRON
ctmj-149	119	9	directly	directly	ADV
ctmj-149	119	10	disrupted	disrupt	VERB
ctmj-149	119	11	the	the	DET
ctmj-149	119	12	structure	structure	NOUN
ctmj-149	119	13	and	and	CCONJ
ctmj-149	119	14	integrity	integrity	NOUN
ctmj-149	119	15	of	of	ADP
ctmj-149	119	16	tjs	tjs	NOUN
ctmj-149	119	17	to	to	PART
ctmj-149	119	18	open	open	VERB
ctmj-149	119	19	the	the	DET
ctmj-149	119	20	bbb	bbb	NOUN
ctmj-149	119	21	barrier	barrier	NOUN
ctmj-149	119	22	.	.	PUNCT
ctmj-149	120	1	these	these	DET
ctmj-149	120	2	results	result	NOUN
ctmj-149	120	3	combined	combine	VERB
ctmj-149	120	4	with	with	ADP
ctmj-149	120	5	previous	previous	ADJ
ctmj-149	120	6	reports	report	NOUN
ctmj-149	120	7	led	lead	VERB
ctmj-149	120	8	us	we	PRON
ctmj-149	120	9	to	to	PART
ctmj-149	120	10	infer	infer	VERB
ctmj-149	120	11	that	that	SCONJ
ctmj-149	120	12	disruption	disruption	NOUN
ctmj-149	120	13	of	of	ADP
ctmj-149	120	14	the	the	DET
ctmj-149	120	15	configuration	configuration	NOUN
ctmj-149	120	16	and	and	CCONJ
ctmj-149	120	17	integrity	integrity	NOUN
ctmj-149	120	18	of	of	ADP
ctmj-149	120	19	tj	tj	NOUN
ctmj-149	120	20	by	by	ADP
ctmj-149	120	21	menthol	menthol	NOUN
ctmj-149	120	22	might	might	AUX
ctmj-149	120	23	be	be	AUX
ctmj-149	120	24	ctmj	ctmj	NOUN
ctmj-149	120	25	|	|	ADV
ctmj-149	120	26	traditionalmedicinejournals.com	traditionalmedicinejournals.com	X
ctmj-149	120	27	chinese	chinese	ADJ
ctmj-149	120	28	traditional	traditional	ADJ
ctmj-149	120	29	medicine	medicine	NOUN
ctmj-149	120	30	journal	journal	NOUN
ctmj-149	120	31	|	|	ADV
ctmj-149	120	32	2024	2024	NUM
ctmj-149	120	33	|	|	ADV
ctmj-149	120	34	vol	vol	NOUN
ctmj-149	120	35	7	7	NUM
ctmj-149	120	36	|	|	NOUN
ctmj-149	120	37	issue	issue	VERB
ctmj-149	120	38	1	1	NUM
ctmj-149	120	39	issn	issn	X
ctmj-149	120	40	:	:	PUNCT
ctmj-149	120	41	2693	2693	NUM
ctmj-149	120	42	6356	6356	NUM
ctmj-149	120	43	2024	2024	NUM
ctmj-149	120	44	|	|	ADV
ctmj-149	120	45	vol	vol	NOUN
ctmj-149	120	46	1	1	NUM
ctmj-149	121	1	|	|	ADV
ctmj-149	121	2	issue	issue	NOUN
ctmj-149	121	3	1	1	NUM
ctmj-149	121	4	caused	cause	VERB
ctmj-149	121	5	by	by	ADP
ctmj-149	121	6	phosphorylation	phosphorylation	NOUN
ctmj-149	121	7	of	of	ADP
ctmj-149	121	8	tj	tj	NOUN
ctmj-149	121	9	components	component	NOUN
ctmj-149	121	10	,	,	PUNCT
ctmj-149	121	11	activation	activation	NOUN
ctmj-149	121	12	of	of	ADP
ctmj-149	121	13	protein	protein	NOUN
ctmj-149	121	14	kinases	kinase	NOUN
ctmj-149	121	15	,	,	PUNCT
ctmj-149	121	16	or	or	CCONJ
ctmj-149	121	17	calcium	calcium	NOUN
ctmj-149	121	18	depletion.49e52	depletion.49e52	NOUN
ctmj-149	121	19	teer	teer	NOUN
ctmj-149	121	20	measurement	measurement	NOUN
ctmj-149	121	21	has	have	AUX
ctmj-149	121	22	been	be	AUX
ctmj-149	121	23	widely	widely	ADV
ctmj-149	121	24	applied	apply	VERB
ctmj-149	121	25	in	in	ADP
ctmj-149	121	26	evalu	evalu	NOUN
ctmj-149	121	27	ating	ate	VERB
ctmj-149	121	28	the	the	DET
ctmj-149	121	29	integrity	integrity	NOUN
ctmj-149	121	30	of	of	ADP
ctmj-149	121	31	the	the	DET
ctmj-149	121	32	monolayer	monolayer	NOUN
ctmj-149	121	33	and	and	CCONJ
ctmj-149	121	34	studying	study	VERB
ctmj-149	121	35	the	the	DET
ctmj-149	121	36	permeability	permeability	NOUN
ctmj-149	121	37	of	of	ADP
ctmj-149	121	38	transport	transport	NOUN
ctmj-149	121	39	processes	process	NOUN
ctmj-149	121	40	.	.	PUNCT
ctmj-149	122	1	changes	change	NOUN
ctmj-149	122	2	in	in	ADP
ctmj-149	122	3	teer	teer	NOUN
ctmj-149	122	4	values	value	NOUN
ctmj-149	122	5	have	have	AUX
ctmj-149	122	6	been	be	AUX
ctmj-149	122	7	directly	directly	ADV
ctmj-149	122	8	linked	link	VERB
ctmj-149	122	9	to	to	ADP
ctmj-149	122	10	the	the	DET
ctmj-149	122	11	function	function	NOUN
ctmj-149	122	12	of	of	ADP
ctmj-149	122	13	the	the	DET
ctmj-149	122	14	paracellular	paracellular	ADJ
ctmj-149	122	15	occluding	occluding	NOUN
ctmj-149	122	16	barrier53,54	barrier53,54	VERB
ctmj-149	122	17	teer	teer	NOUN
ctmj-149	122	18	is	be	AUX
ctmj-149	122	19	caused	cause	VERB
ctmj-149	122	20	by	by	ADP
ctmj-149	122	21	cell	cell	NOUN
ctmj-149	122	22	substrate	substrate	NOUN
ctmj-149	122	23	contact	contact	NOUN
ctmj-149	122	24	,	,	PUNCT
ctmj-149	122	25	and	and	CCONJ
ctmj-149	122	26	if	if	SCONJ
ctmj-149	122	27	the	the	DET
ctmj-149	122	28	distance	distance	NOUN
ctmj-149	122	29	of	of	ADP
ctmj-149	122	30	the	the	DET
ctmj-149	122	31	cellsubstrate	cellsubstrate	NOUN
ctmj-149	122	32	is	be	AUX
ctmj-149	122	33	short	short	ADJ
ctmj-149	122	34	,	,	PUNCT
ctmj-149	122	35	a	a	DET
ctmj-149	122	36	high	high	ADJ
ctmj-149	122	37	teer	teer	NOUN
ctmj-149	122	38	value	value	NOUN
ctmj-149	122	39	is	be	AUX
ctmj-149	122	40	observed	observe	VERB
ctmj-149	122	41	.	.	PUNCT
ctmj-149	123	1	based	base	VERB
ctmj-149	123	2	on	on	ADP
ctmj-149	123	3	this	this	DET
ctmj-149	123	4	physiologic	physiologic	ADJ
ctmj-149	123	5	characteristic	characteristic	NOUN
ctmj-149	123	6	,	,	PUNCT
ctmj-149	123	7	paracellular	paracellular	ADJ
ctmj-149	123	8	resistance	resistance	NOUN
ctmj-149	123	9	and	and	CCONJ
ctmj-149	123	10	the	the	DET
ctmj-149	123	11	average	average	ADJ
ctmj-149	123	12	cell	cell	NOUN
ctmj-149	123	13	-	-	PUNCT
ctmj-149	123	14	substrate	substrate	NOUN
ctmj-149	123	15	distance	distance	NOUN
ctmj-149	123	16	can	can	AUX
ctmj-149	123	17	be	be	AUX
ctmj-149	123	18	estimated	estimate	VERB
ctmj-149	123	19	by	by	ADP
ctmj-149	123	20	the	the	DET
ctmj-149	123	21	teer	teer	NOUN
ctmj-149	123	22	.	.	PUNCT
ctmj-149	124	1	paracellular	paracellular	ADJ
ctmj-149	124	2	resistance	resistance	NOUN
ctmj-149	124	3	consists	consist	VERB
ctmj-149	124	4	of	of	ADP
ctmj-149	124	5	the	the	DET
ctmj-149	124	6	serial	serial	ADJ
ctmj-149	124	7	resistance	resistance	NOUN
ctmj-149	124	8	of	of	ADP
ctmj-149	124	9	the	the	DET
ctmj-149	124	10	tjs	tjs	NOUN
ctmj-149	124	11	as	as	ADV
ctmj-149	124	12	well	well	ADV
ctmj-149	124	13	as	as	ADP
ctmj-149	124	14	lateral	lateral	ADJ
ctmj-149	124	15	intercellular	intercellular	ADJ
ctmj-149	124	16	resis	resis	NOUN
ctmj-149	124	17	tence.55	tence.55	NOUN
ctmj-149	124	18	therefore	therefore	ADV
ctmj-149	124	19	,	,	PUNCT
ctmj-149	124	20	to	to	PART
ctmj-149	124	21	establish	establish	VERB
ctmj-149	124	22	the	the	DET
ctmj-149	124	23	relationship	relationship	NOUN
ctmj-149	124	24	between	between	ADP
ctmj-149	124	25	the	the	DET
ctmj-149	124	26	change	change	NOUN
ctmj-149	124	27	in	in	ADP
ctmj-149	124	28	teer	teer	PROPN
ctmj-149	124	29	and	and	CCONJ
ctmj-149	124	30	the	the	DET
ctmj-149	124	31	state	state	NOUN
ctmj-149	124	32	of	of	ADP
ctmj-149	124	33	tj	tj	PROPN
ctmj-149	124	34	barrier	barrier	NOUN
ctmj-149	124	35	function	function	NOUN
ctmj-149	124	36	,	,	PUNCT
ctmj-149	124	37	we	we	PRON
ctmj-149	124	38	used	use	VERB
ctmj-149	124	39	evom	evom	NOUN
ctmj-149	124	40	instrumentation	instrumentation	NOUN
ctmj-149	124	41	to	to	PART
ctmj-149	124	42	determine	determine	VERB
ctmj-149	124	43	the	the	DET
ctmj-149	124	44	teer	teer	NOUN
ctmj-149	124	45	of	of	ADP
ctmj-149	124	46	two	two	NUM
ctmj-149	124	47	kinds	kind	NOUN
ctmj-149	124	48	of	of	ADP
ctmj-149	124	49	cells	cell	NOUN
ctmj-149	124	50	at	at	ADP
ctmj-149	124	51	different	different	ADJ
ctmj-149	124	52	time	time	NOUN
ctmj-149	124	53	points	point	NOUN
ctmj-149	124	54	after	after	ADP
ctmj-149	124	55	treatment	treatment	NOUN
ctmj-149	124	56	with	with	ADP
ctmj-149	124	57	the	the	DET
ctmj-149	124	58	compounds	compound	NOUN
ctmj-149	124	59	.	.	PUNCT
ctmj-149	125	1	the	the	DET
ctmj-149	125	2	results	result	NOUN
ctmj-149	125	3	were	be	AUX
ctmj-149	125	4	consistent	consistent	ADJ
ctmj-149	125	5	with	with	ADP
ctmj-149	125	6	those	those	PRON
ctmj-149	125	7	of	of	ADP
ctmj-149	125	8	immunocytochemistry	immunocytochemistry	NOUN
ctmj-149	125	9	,	,	PUNCT
ctmj-149	125	10	and	and	CCONJ
ctmj-149	125	11	revealed	reveal	VERB
ctmj-149	125	12	that	that	SCONJ
ctmj-149	125	13	teer	teer	PROPN
ctmj-149	125	14	value	value	NOUN
ctmj-149	125	15	gradually	gradually	ADV
ctmj-149	125	16	declined	decline	VERB
ctmj-149	125	17	following	follow	VERB
ctmj-149	125	18	treatment	treatment	NOUN
ctmj-149	125	19	of	of	ADP
ctmj-149	125	20	cells	cell	NOUN
ctmj-149	125	21	with	with	ADP
ctmj-149	125	22	menthol	menthol	NOUN
ctmj-149	125	23	,	,	PUNCT
ctmj-149	125	24	and	and	CCONJ
ctmj-149	125	25	values	value	NOUN
ctmj-149	125	26	of	of	ADP
ctmj-149	125	27	the	the	DET
ctmj-149	125	28	other	other	ADJ
ctmj-149	125	29	groups	group	NOUN
ctmj-149	125	30	were	be	AUX
ctmj-149	125	31	relatively	relatively	ADV
ctmj-149	125	32	stable	stable	ADJ
ctmj-149	125	33	during	during	ADP
ctmj-149	125	34	the	the	DET
ctmj-149	125	35	test	test	NOUN
ctmj-149	125	36	period	period	NOUN
ctmj-149	125	37	.	.	PUNCT
ctmj-149	126	1	therefore	therefore	ADV
ctmj-149	126	2	,	,	PUNCT
ctmj-149	126	3	this	this	DET
ctmj-149	126	4	experiment	experiment	NOUN
ctmj-149	126	5	showed	show	VERB
ctmj-149	126	6	that	that	SCONJ
ctmj-149	126	7	menthol	menthol	NOUN
ctmj-149	126	8	is	be	AUX
ctmj-149	126	9	capable	capable	ADJ
ctmj-149	126	10	of	of	ADP
ctmj-149	126	11	weakening	weaken	VERB
ctmj-149	126	12	the	the	DET
ctmj-149	126	13	bbb	bbb	NOUN
ctmj-149	126	14	and	and	CCONJ
ctmj-149	126	15	enhancing	enhance	VERB
ctmj-149	126	16	paracellular	paracellular	ADJ
ctmj-149	126	17	transport	transport	NOUN
ctmj-149	126	18	.	.	PUNCT
ctmj-149	127	1	the	the	DET
ctmj-149	127	2	mechanism	mechanism	NOUN
ctmj-149	127	3	of	of	ADP
ctmj-149	127	4	the	the	DET
ctmj-149	127	5	decrease	decrease	NOUN
ctmj-149	127	6	in	in	ADP
ctmj-149	127	7	teer	teer	PROPN
ctmj-149	127	8	also	also	ADV
ctmj-149	127	9	involves	involve	VERB
ctmj-149	127	10	ca2	ca2	PROPN
ctmj-149	127	11	+	+	X
ctmj-149	127	12	influx	influx	NOUN
ctmj-149	127	13	and	and	CCONJ
ctmj-149	127	14	the	the	DET
ctmj-149	127	15	ca2	ca2	PROPN
ctmj-149	127	16	+	+	PROPN
ctmj-149	127	17	chelator	chelator	NOUN
ctmj-149	127	18	egta	egta	NOUN
ctmj-149	127	19	blocked	block	VERB
ctmj-149	127	20	cofilin	cofilin	PROPN
ctmj-149	127	21	dephosphorylation	dephosphorylation	NOUN
ctmj-149	127	22	.	.	PUNCT
ctmj-149	128	1	further	far	ADV
ctmj-149	128	2	more	more	ADV
ctmj-149	128	3	,	,	PUNCT
ctmj-149	128	4	the	the	DET
ctmj-149	128	5	alteration	alteration	NOUN
ctmj-149	128	6	may	may	AUX
ctmj-149	128	7	have	have	AUX
ctmj-149	128	8	been	be	AUX
ctmj-149	128	9	caused	cause	VERB
ctmj-149	128	10	by	by	ADP
ctmj-149	128	11	activity	activity	NOUN
ctmj-149	128	12	variation	variation	NOUN
ctmj-149	128	13	of	of	ADP
ctmj-149	128	14	intrinsic	intrinsic	ADJ
ctmj-149	128	15	membrane	membrane	NOUN
ctmj-149	128	16	proteins.56	proteins.56	NOUN
ctmj-149	128	17	for	for	ADP
ctmj-149	128	18	example	example	NOUN
ctmj-149	128	19	,	,	PUNCT
ctmj-149	128	20	removal	removal	NOUN
ctmj-149	128	21	and	and	CCONJ
ctmj-149	128	22	addition	addition	NOUN
ctmj-149	128	23	of	of	ADP
ctmj-149	128	24	ca2	ca2	PROPN
ctmj-149	128	25	+	+	ADP
ctmj-149	128	26	to	to	ADP
ctmj-149	128	27	the	the	DET
ctmj-149	128	28	filter	filter	NOUN
ctmj-149	128	29	where	where	SCONJ
ctmj-149	128	30	mdck	mdck	ADJ
ctmj-149	128	31	cell	cell	NOUN
ctmj-149	128	32	layers	layer	NOUN
ctmj-149	128	33	form	form	VERB
ctmj-149	128	34	a	a	DET
ctmj-149	128	35	monolayer	monolayer	NOUN
ctmj-149	128	36	may	may	AUX
ctmj-149	128	37	reversibly	reversibly	ADV
ctmj-149	128	38	lead	lead	VERB
ctmj-149	128	39	to	to	ADP
ctmj-149	128	40	their	their	PRON
ctmj-149	128	41	tjs	tjs	NOUN
ctmj-149	128	42	opening	opening	NOUN
ctmj-149	128	43	and	and	CCONJ
ctmj-149	128	44	resealing	resealing	NOUN
ctmj-149	128	45	,	,	PUNCT
ctmj-149	128	46	and	and	CCONJ
ctmj-149	128	47	the	the	DET
ctmj-149	128	48	cell	cell	NOUN
ctmj-149	128	49	-	-	PUNCT
ctmj-149	128	50	substrate	substrate	NOUN
ctmj-149	128	51	separation	separation	NOUN
ctmj-149	128	52	may	may	AUX
ctmj-149	128	53	correspondingly	correspondingly	ADV
ctmj-149	128	54	increase	increase	VERB
ctmj-149	128	55	or	or	CCONJ
ctmj-149	128	56	decrease.57	decrease.57	VERB
ctmj-149	128	57	in	in	ADP
ctmj-149	128	58	addition	addition	NOUN
ctmj-149	128	59	,	,	PUNCT
ctmj-149	128	60	we	we	PRON
ctmj-149	128	61	were	be	AUX
ctmj-149	128	62	surprised	surprised	ADJ
ctmj-149	128	63	to	to	PART
ctmj-149	128	64	find	find	VERB
ctmj-149	128	65	that	that	DET
ctmj-149	128	66	reduction	reduction	NOUN
ctmj-149	128	67	in	in	ADP
ctmj-149	128	68	teer	teer	NOUN
ctmj-149	128	69	of	of	ADP
ctmj-149	128	70	the	the	DET
ctmj-149	128	71	mdck	mdck	PROPN
ctmj-149	128	72	cells	cell	NOUN
ctmj-149	128	73	occurred	occur	VERB
ctmj-149	128	74	earlier	early	ADV
ctmj-149	128	75	than	than	SCONJ
ctmj-149	128	76	it	it	PRON
ctmj-149	128	77	did	do	VERB
ctmj-149	128	78	in	in	ADP
ctmj-149	128	79	mdck	mdck	PROPN
ctmj-149	128	80	-	-	PUNCT
ctmj-149	128	81	mdr1	mdr1	PROPN
ctmj-149	128	82	cells	cell	NOUN
ctmj-149	128	83	,	,	PUNCT
ctmj-149	128	84	which	which	PRON
ctmj-149	128	85	suggests	suggest	VERB
ctmj-149	128	86	that	that	SCONJ
ctmj-149	128	87	the	the	DET
ctmj-149	128	88	tj	tj	NOUN
ctmj-149	128	89	barrier	barrier	NOUN
ctmj-149	128	90	in	in	ADP
ctmj-149	128	91	the	the	DET
ctmj-149	128	92	mdck	mdck	PROPN
ctmj-149	128	93	-	-	PUNCT
ctmj-149	128	94	mdr1	mdr1	PROPN
ctmj-149	128	95	was	be	AUX
ctmj-149	128	96	stronger	strong	ADJ
ctmj-149	128	97	than	than	SCONJ
ctmj-149	128	98	it	it	PRON
ctmj-149	128	99	was	be	AUX
ctmj-149	128	100	in	in	ADP
ctmj-149	128	101	mdck	mdck	PROPN
ctmj-149	128	102	,	,	PUNCT
ctmj-149	128	103	and	and	CCONJ
ctmj-149	128	104	menthol	menthol	NOUN
ctmj-149	128	105	might	might	AUX
ctmj-149	128	106	have	have	VERB
ctmj-149	128	107	a	a	DET
ctmj-149	128	108	rapid	rapid	ADJ
ctmj-149	128	109	onset	onset	NOUN
ctmj-149	128	110	of	of	ADP
ctmj-149	128	111	action	action	NOUN
ctmj-149	128	112	in	in	ADP
ctmj-149	128	113	mdck	mdck	PROPN
ctmj-149	128	114	cells	cell	NOUN
ctmj-149	128	115	.	.	PUNCT
ctmj-149	129	1	our	our	PRON
ctmj-149	129	2	previous	previous	ADJ
ctmj-149	129	3	research	research	NOUN
ctmj-149	129	4	in	in	ADP
ctmj-149	129	5	rats	rat	NOUN
ctmj-149	129	6	and	and	CCONJ
ctmj-149	129	7	mice	mouse	NOUN
ctmj-149	129	8	on	on	ADP
ctmj-149	129	9	the	the	DET
ctmj-149	129	10	pharma	pharma	PROPN
ctmj-149	129	11	cokinetics	cokinetic	NOUN
ctmj-149	129	12	of	of	ADP
ctmj-149	129	13	puerarin	puerarin	NOUN
ctmj-149	129	14	in	in	ADP
ctmj-149	129	15	tongqiaosanyu	tongqiaosanyu	NOUN
ctmj-149	129	16	prescription	prescription	NOUN
ctmj-149	129	17	used	use	VERB
ctmj-149	129	18	different	different	ADJ
ctmj-149	129	19	methods	method	NOUN
ctmj-149	129	20	of	of	ADP
ctmj-149	129	21	administration	administration	NOUN
ctmj-149	129	22	,	,	PUNCT
ctmj-149	129	23	including	include	VERB
ctmj-149	129	24	caudal	caudal	NOUN
ctmj-149	129	25	vein	vein	VERB
ctmj-149	129	26	injection	injection	NOUN
ctmj-149	129	27	as	as	ADV
ctmj-149	129	28	well	well	ADV
ctmj-149	129	29	as	as	ADP
ctmj-149	129	30	nasal	nasal	NOUN
ctmj-149	129	31	and	and	CCONJ
ctmj-149	129	32	oral	oral	ADJ
ctmj-149	129	33	administration	administration	NOUN
ctmj-149	129	34	.	.	PUNCT
ctmj-149	130	1	the	the	DET
ctmj-149	130	2	study	study	NOUN
ctmj-149	130	3	employed	employ	VERB
ctmj-149	130	4	reversed	reverse	VERB
ctmj-149	130	5	-	-	PUNCT
ctmj-149	130	6	phase	phase	NOUN
ctmj-149	130	7	high	high	ADJ
ctmj-149	130	8	-	-	PUNCT
ctmj-149	130	9	performance	performance	NOUN
ctmj-149	130	10	liquid	liquid	NOUN
ctmj-149	130	11	chromatography(rp	chromatography(rp	NOUN
ctmj-149	130	12	-	-	PUNCT
ctmj-149	130	13	hplc	hplc	NOUN
ctmj-149	130	14	)	)	PUNCT
ctmj-149	130	15	to	to	PART
ctmj-149	130	16	determine	determine	VERB
ctmj-149	130	17	the	the	DET
ctmj-149	130	18	concentration	concentration	NOUN
ctmj-149	130	19	of	of	ADP
ctmj-149	130	20	the	the	DET
ctmj-149	130	21	puerarin	puerarin	NOUN
ctmj-149	130	22	in	in	ADP
ctmj-149	130	23	blood	blood	NOUN
ctmj-149	130	24	and	and	CCONJ
ctmj-149	130	25	brain	brain	NOUN
ctmj-149	130	26	tissue	tissue	NOUN
ctmj-149	130	27	samples	sample	NOUN
ctmj-149	130	28	,	,	PUNCT
ctmj-149	130	29	which	which	PRON
ctmj-149	130	30	were	be	AUX
ctmj-149	130	31	collected	collect	VERB
ctmj-149	130	32	at	at	ADP
ctmj-149	130	33	different	different	ADJ
ctmj-149	130	34	time	time	NOUN
ctmj-149	130	35	points	point	NOUN
ctmj-149	130	36	.	.	PUNCT
ctmj-149	131	1	pharmacokinetics	pharmacokinetic	NOUN
ctmj-149	131	2	in	in	ADP
ctmj-149	131	3	rats	rat	NOUN
ctmj-149	131	4	showed	show	VERB
ctmj-149	131	5	that	that	SCONJ
ctmj-149	131	6	auc0en	auc0en	PROPN
ctmj-149	131	7	following	follow	VERB
ctmj-149	131	8	nasal	nasal	PROPN
ctmj-149	131	9	administration	administration	PROPN
ctmj-149	131	10	was	be	AUX
ctmj-149	131	11	376.56	376.56	NUM
ctmj-149	131	12	93.93	93.93	NUM
ctmj-149	131	13	mg	mg	PROPN
ctmj-149	131	14	/	/	SYM
ctmj-149	131	15	min	min	NOUN
ctmj-149	131	16	/	/	SYM
ctmj-149	131	17	l	l	NOUN
ctmj-149	131	18	and	and	CCONJ
ctmj-149	131	19	absolute	absolute	ADJ
ctmj-149	131	20	bioavailability	bioavailability	NOUN
ctmj-149	131	21	of	of	ADP
ctmj-149	131	22	puerarin	puerarin	NOUN
ctmj-149	131	23	was	be	AUX
ctmj-149	131	24	47.78	47.78	NUM
ctmj-149	131	25	%	%	NOUN
ctmj-149	131	26	by	by	ADP
ctmj-149	131	27	nasal	nasal	PROPN
ctmj-149	131	28	administration	administration	PROPN
ctmj-149	131	29	,	,	PUNCT
ctmj-149	131	30	which	which	PRON
ctmj-149	131	31	was	be	AUX
ctmj-149	131	32	significantly	significantly	ADV
ctmj-149	131	33	higher	high	ADJ
ctmj-149	131	34	than	than	ADP
ctmj-149	131	35	oral	oral	ADJ
ctmj-149	131	36	administration	administration	NOUN
ctmj-149	131	37	.	.	PUNCT
ctmj-149	132	1	these	these	DET
ctmj-149	132	2	results	result	NOUN
ctmj-149	132	3	were	be	AUX
ctmj-149	132	4	the	the	DET
ctmj-149	132	5	basis	basis	NOUN
ctmj-149	132	6	for	for	ADP
ctmj-149	132	7	our	our	PRON
ctmj-149	132	8	choosing	choose	VERB
ctmj-149	132	9	nasal	nasal	PROPN
ctmj-149	132	10	administration	administration	PROPN
ctmj-149	132	11	of	of	ADP
ctmj-149	132	12	tongqiaosanyu	tongqiaosanyu	PROPN
ctmj-149	132	13	prescription	prescription	NOUN
ctmj-149	132	14	.	.	PUNCT
ctmj-149	133	1	plasma	plasma	NOUN
ctmj-149	133	2	and	and	CCONJ
ctmj-149	133	3	brain	brain	NOUN
ctmj-149	133	4	pharmaco	pharmaco	NOUN
ctmj-149	133	5	kinetics	kinetic	NOUN
ctmj-149	133	6	in	in	ADP
ctmj-149	133	7	mice	mouse	NOUN
ctmj-149	133	8	indicated	indicate	VERB
ctmj-149	133	9	that	that	SCONJ
ctmj-149	133	10	the	the	DET
ctmj-149	133	11	brain	brain	NOUN
ctmj-149	133	12	targeting	target	VERB
ctmj-149	133	13	coeffi	coeffi	PROPN
ctmj-149	133	14	cient	cient	NOUN
ctmj-149	133	15	(	(	PUNCT
ctmj-149	133	16	re	re	NOUN
ctmj-149	133	17	)	)	PUNCT
ctmj-149	133	18	was	be	AUX
ctmj-149	133	19	132.25	132.25	NUM
ctmj-149	133	20	%	%	NOUN
ctmj-149	133	21	following	follow	VERB
ctmj-149	133	22	intranasal	intranasal	ADJ
ctmj-149	133	23	administration	administration	NOUN
ctmj-149	133	24	and	and	CCONJ
ctmj-149	133	25	the	the	DET
ctmj-149	133	26	brain	brain	NOUN
ctmj-149	133	27	drug	drug	NOUN
ctmj-149	133	28	targeting	target	VERB
ctmj-149	133	29	index	index	NOUN
ctmj-149	133	30	(	(	PUNCT
ctmj-149	133	31	dti	dti	PROPN
ctmj-149	133	32	)	)	PUNCT
ctmj-149	133	33	was	be	AUX
ctmj-149	133	34	2.70	2.70	NUM
ctmj-149	133	35	,	,	PUNCT
ctmj-149	133	36	both	both	PRON
ctmj-149	133	37	of	of	ADP
ctmj-149	133	38	which	which	PRON
ctmj-149	133	39	were	be	AUX
ctmj-149	133	40	significantly	significantly	ADV
ctmj-149	133	41	higher	high	ADJ
ctmj-149	133	42	than	than	ADP
ctmj-149	133	43	re	re	ADP
ctmj-149	133	44	and	and	CCONJ
ctmj-149	133	45	dti	dti	PROPN
ctmj-149	133	46	obtained	obtain	VERB
ctmj-149	133	47	following	follow	VERB
ctmj-149	133	48	injection	injection	NOUN
ctmj-149	133	49	administration	administration	NOUN
ctmj-149	133	50	.	.	PUNCT
ctmj-149	134	1	these	these	DET
ctmj-149	134	2	results	result	NOUN
ctmj-149	134	3	showed	show	VERB
ctmj-149	134	4	that	that	SCONJ
ctmj-149	134	5	intranasal	intranasal	ADJ
ctmj-149	134	6	administration	administration	NOUN
ctmj-149	134	7	enhanced	enhance	VERB
ctmj-149	134	8	the	the	DET
ctmj-149	134	9	medicine	medicine	NOUN
ctmj-149	134	10	’s	’s	PART
ctmj-149	134	11	penetration	penetration	NOUN
ctmj-149	134	12	and	and	CCONJ
ctmj-149	134	13	absorption	absorption	NOUN
ctmj-149	134	14	into	into	ADP
ctmj-149	134	15	the	the	DET
ctmj-149	134	16	brain.58	brain.58	NOUN
ctmj-149	134	17	furthermore	furthermore	ADV
ctmj-149	134	18	,	,	PUNCT
ctmj-149	134	19	we	we	PRON
ctmj-149	134	20	used	use	VERB
ctmj-149	134	21	the	the	DET
ctmj-149	134	22	abdominal	abdominal	ADJ
ctmj-149	134	23	skin	skin	NOUN
ctmj-149	134	24	of	of	ADP
ctmj-149	134	25	the	the	DET
ctmj-149	134	26	american	american	ADJ
ctmj-149	134	27	bullfrog	bullfrog	PROPN
ctmj-149	134	28	rana	rana	PROPN
ctmj-149	134	29	catesbeiana	catesbeiana	PROPN
ctmj-149	134	30	as	as	ADP
ctmj-149	134	31	an	an	DET
ctmj-149	134	32	in	in	ADP
ctmj-149	134	33	vitro	vitro	X
ctmj-149	134	34	model	model	NOUN
ctmj-149	134	35	to	to	PART
ctmj-149	134	36	study	study	VERB
ctmj-149	134	37	the	the	DET
ctmj-149	134	38	effect	effect	NOUN
ctmj-149	134	39	of	of	ADP
ctmj-149	134	40	different	different	ADJ
ctmj-149	134	41	concentrations	concentration	NOUN
ctmj-149	134	42	of	of	ADP
ctmj-149	134	43	puerarin	puerarin	NOUN
ctmj-149	134	44	and	and	CCONJ
ctmj-149	134	45	the	the	DET
ctmj-149	134	46	effect	effect	NOUN
ctmj-149	134	47	of	of	ADP
ctmj-149	134	48	different	different	ADJ
ctmj-149	134	49	proportions	proportion	NOUN
ctmj-149	134	50	of	of	ADP
ctmj-149	134	51	menthol	menthol	NOUN
ctmj-149	134	52	on	on	ADP
ctmj-149	134	53	the	the	DET
ctmj-149	134	54	apparent	apparent	ADJ
ctmj-149	134	55	perme	perme	ADJ
ctmj-149	134	56	ability	ability	NOUN
ctmj-149	134	57	coefficient	coefficient	NOUN
ctmj-149	134	58	(	(	PUNCT
ctmj-149	134	59	papp	papp	NOUN
ctmj-149	134	60	)	)	PUNCT
ctmj-149	134	61	using	use	VERB
ctmj-149	134	62	the	the	DET
ctmj-149	134	63	franz	franz	NOUN
ctmj-149	134	64	diffusion	diffusion	NOUN
ctmj-149	134	65	cell	cell	NOUN
ctmj-149	134	66	sys	sys	X
ctmj-149	134	67	tem	tem	PROPN
ctmj-149	134	68	and	and	CCONJ
ctmj-149	134	69	hplc	hplc	PROPN
ctmj-149	134	70	.	.	PUNCT
ctmj-149	135	1	the	the	DET
ctmj-149	135	2	results	result	NOUN
ctmj-149	135	3	showed	show	VERB
ctmj-149	135	4	there	there	PRON
ctmj-149	135	5	was	be	VERB
ctmj-149	135	6	no	no	DET
ctmj-149	135	7	significant	significant	ADJ
ctmj-149	135	8	difference	difference	NOUN
ctmj-149	135	9	in	in	ADP
ctmj-149	135	10	the	the	DET
ctmj-149	135	11	effects	effect	NOUN
ctmj-149	135	12	of	of	ADP
ctmj-149	135	13	different	different	ADJ
ctmj-149	135	14	concentrations	concentration	NOUN
ctmj-149	135	15	of	of	ADP
ctmj-149	135	16	puerarin	puerarin	NOUN
ctmj-149	135	17	on	on	ADP
ctmj-149	135	18	papp	papp	NOUN
ctmj-149	135	19	,	,	PUNCT
ctmj-149	135	20	indicating	indicate	VERB
ctmj-149	135	21	that	that	SCONJ
ctmj-149	135	22	the	the	DET
ctmj-149	135	23	permeation	permeation	NOUN
ctmj-149	135	24	of	of	ADP
ctmj-149	135	25	puerarin	puerarin	NOUN
ctmj-149	135	26	is	be	AUX
ctmj-149	135	27	via	via	ADP
ctmj-149	135	28	passive	passive	ADJ
ctmj-149	135	29	diffusion	diffusion	NOUN
ctmj-149	135	30	.	.	PUNCT
ctmj-149	136	1	furthermore	furthermore	ADV
ctmj-149	136	2	,	,	PUNCT
ctmj-149	136	3	when	when	SCONJ
ctmj-149	136	4	the	the	DET
ctmj-149	136	5	mass	mass	ADJ
ctmj-149	136	6	con	con	NOUN
ctmj-149	136	7	centration	centration	NOUN
ctmj-149	136	8	of	of	ADP
ctmj-149	136	9	menthol	menthol	NOUN
ctmj-149	136	10	was	be	AUX
ctmj-149	136	11	5	5	NUM
ctmj-149	136	12	mg	mg	NUM
ctmj-149	136	13	/	/	SYM
ctmj-149	136	14	l	l	NOUN
ctmj-149	136	15	,	,	PUNCT
ctmj-149	136	16	there	there	PRON
ctmj-149	136	17	was	be	VERB
ctmj-149	136	18	a	a	DET
ctmj-149	136	19	significant	significant	ADJ
ctmj-149	136	20	difference	difference	NOUN
ctmj-149	136	21	compared	compare	VERB
ctmj-149	136	22	with	with	ADP
ctmj-149	136	23	the	the	DET
ctmj-149	136	24	puerarin	puerarin	NOUN
ctmj-149	136	25	group	group	NOUN
ctmj-149	136	26	,	,	PUNCT
ctmj-149	136	27	which	which	PRON
ctmj-149	136	28	proved	prove	VERB
ctmj-149	136	29	that	that	PRON
ctmj-149	136	30	menthol	menthol	NOUN
ctmj-149	136	31	enhanced	enhance	VERB
ctmj-149	136	32	the	the	DET
ctmj-149	136	33	permeation	permeation	NOUN
ctmj-149	136	34	of	of	ADP
ctmj-149	136	35	puerarin	puerarin	NOUN
ctmj-149	136	36	at	at	ADP
ctmj-149	136	37	a	a	DET
ctmj-149	136	38	certain	certain	ADJ
ctmj-149	136	39	concentrationrange.59	concentrationrange.59	VERB
ctmj-149	136	40	the	the	DET
ctmj-149	136	41	main	main	ADJ
ctmj-149	136	42	limitation	limitation	NOUN
ctmj-149	136	43	of	of	ADP
ctmj-149	136	44	this	this	DET
ctmj-149	136	45	study	study	NOUN
ctmj-149	136	46	is	be	AUX
ctmj-149	136	47	that	that	SCONJ
ctmj-149	136	48	we	we	PRON
ctmj-149	136	49	only	only	ADV
ctmj-149	136	50	explored	explore	VERB
ctmj-149	136	51	a	a	DET
ctmj-149	136	52	single	single	ADJ
ctmj-149	136	53	drug	drug	NOUN
ctmj-149	136	54	dose	dose	NOUN
ctmj-149	136	55	.	.	PUNCT
ctmj-149	137	1	future	future	ADJ
ctmj-149	137	2	studies	study	NOUN
ctmj-149	137	3	will	will	AUX
ctmj-149	137	4	further	far	ADV
ctmj-149	137	5	investigate	investigate	VERB
ctmj-149	137	6	the	the	DET
ctmj-149	137	7	dose	dose	NOUN
ctmj-149	137	8	-	-	PUNCT
ctmj-149	137	9	effect	effect	NOUN
ctmj-149	137	10	relationship	relationship	NOUN
ctmj-149	137	11	.	.	PUNCT
ctmj-149	138	1	therefore	therefore	ADV
ctmj-149	138	2	,	,	PUNCT
ctmj-149	138	3	the	the	DET
ctmj-149	138	4	mechanism	mechanism	NOUN
ctmj-149	138	5	underlying	underlie	VERB
ctmj-149	138	6	the	the	DET
ctmj-149	138	7	effect	effect	NOUN
ctmj-149	138	8	of	of	ADP
ctmj-149	138	9	drugs	drug	NOUN
ctmj-149	138	10	on	on	ADP
ctmj-149	138	11	the	the	DET
ctmj-149	138	12	tj	tj	NOUN
ctmj-149	138	13	and	and	CCONJ
ctmj-149	138	14	transport	transport	NOUN
ctmj-149	138	15	through	through	ADP
ctmj-149	138	16	the	the	DET
ctmj-149	138	17	bbb	bbb	PROPN
ctmj-149	138	18	needs	need	VERB
ctmj-149	138	19	further	further	ADJ
ctmj-149	138	20	elucidation	elucidation	NOUN
ctmj-149	138	21	.	.	PUNCT
ctmj-149	139	1	conclusion	conclusion	NOUN
ctmj-149	139	2	in	in	ADP
ctmj-149	139	3	conclusion	conclusion	NOUN
ctmj-149	139	4	,	,	PUNCT
ctmj-149	139	5	this	this	DET
ctmj-149	139	6	preliminary	preliminary	ADJ
ctmj-149	139	7	investigation	investigation	NOUN
ctmj-149	139	8	demonstrated	demonstrate	VERB
ctmj-149	139	9	the	the	DET
ctmj-149	139	10	mechanism	mechanism	NOUN
ctmj-149	139	11	of	of	ADP
ctmj-149	139	12	puerarin	puerarin	NOUN
ctmj-149	139	13	,	,	PUNCT
ctmj-149	139	14	paeoniflorin	paeoniflorin	NOUN
ctmj-149	139	15	,	,	PUNCT
ctmj-149	139	16	and	and	CCONJ
ctmj-149	139	17	menthol	menthol	NOUN
ctmj-149	139	18	on	on	ADP
ctmj-149	139	19	tj	tj	NOUN
ctmj-149	139	20	proteins	protein	NOUN
ctmj-149	139	21	and	and	CCONJ
ctmj-149	139	22	teer	teer	NOUN
ctmj-149	139	23	.	.	PUNCT
ctmj-149	140	1	compared	compare	VERB
ctmj-149	140	2	with	with	ADP
ctmj-149	140	3	puerarin	puerarin	NOUN
ctmj-149	140	4	and	and	CCONJ
ctmj-149	140	5	paeoniflorin	paeoniflorin	NOUN
ctmj-149	140	6	,	,	PUNCT
ctmj-149	140	7	menthol	menthol	NOUN
ctmj-149	140	8	in	in	ADP
ctmj-149	140	9	tongqiaosanyu	tongqiaosanyu	NOUN
ctmj-149	140	10	prescription	prescription	NOUN
ctmj-149	140	11	affected	affect	VERB
ctmj-149	140	12	the	the	DET
ctmj-149	140	13	tj	tj	NOUN
ctmj-149	140	14	structure	structure	NOUN
ctmj-149	140	15	and	and	CCONJ
ctmj-149	140	16	function	function	NOUN
ctmj-149	140	17	in	in	ADP
ctmj-149	140	18	mdck	mdck	PROPN
ctmj-149	140	19	and	and	CCONJ
ctmj-149	140	20	mdck	mdck	PROPN
ctmj-149	140	21	-	-	PUNCT
ctmj-149	140	22	mdr1	mdr1	PROPN
ctmj-149	140	23	cells	cell	NOUN
ctmj-149	140	24	,	,	PUNCT
ctmj-149	140	25	which	which	PRON
ctmj-149	140	26	were	be	AUX
ctmj-149	140	27	used	use	VERB
ctmj-149	140	28	as	as	ADP
ctmj-149	140	29	in	in	ADP
ctmj-149	140	30	vitro	vitro	X
ctmj-149	140	31	bbb	bbb	PROPN
ctmj-149	140	32	models	model	NOUN
ctmj-149	140	33	.	.	PUNCT
ctmj-149	141	1	menthol	menthol	PROPN
ctmj-149	141	2	inhibited	inhibit	VERB
ctmj-149	141	3	occludin	occludin	PROPN
ctmj-149	141	4	,	,	PUNCT
ctmj-149	141	5	claudin-1	claudin-1	PROPN
ctmj-149	141	6	,	,	PUNCT
ctmj-149	141	7	and	and	CCONJ
ctmj-149	141	8	f	f	X
ctmj-149	141	9	-	-	PUNCT
ctmj-149	141	10	actin	actin	NOUN
ctmj-149	141	11	,	,	PUNCT
ctmj-149	141	12	which	which	PRON
ctmj-149	141	13	suggests	suggest	VERB
ctmj-149	141	14	that	that	SCONJ
ctmj-149	141	15	it	it	PRON
ctmj-149	141	16	may	may	AUX
ctmj-149	141	17	be	be	AUX
ctmj-149	141	18	a	a	DET
ctmj-149	141	19	potential	potential	ADJ
ctmj-149	141	20	drug	drug	NOUN
ctmj-149	141	21	for	for	ADP
ctmj-149	141	22	enhancing	enhance	VERB
ctmj-149	141	23	the	the	DET
ctmj-149	141	24	transport	transport	NOUN
ctmj-149	141	25	of	of	ADP
ctmj-149	141	26	other	other	ADJ
ctmj-149	141	27	drugs	drug	NOUN
ctmj-149	141	28	though	though	SCONJ
ctmj-149	141	29	the	the	DET
ctmj-149	141	30	bbb	bbb	PROPN
ctmj-149	141	31	and	and	CCONJ
ctmj-149	141	32	,	,	PUNCT
ctmj-149	141	33	thereby	thereby	ADV
ctmj-149	141	34	,	,	PUNCT
ctmj-149	141	35	improving	improve	VERB
ctmj-149	141	36	their	their	PRON
ctmj-149	141	37	permeation	permeation	NOUN
ctmj-149	141	38	in	in	ADP
ctmj-149	141	39	the	the	DET
ctmj-149	141	40	brain	brain	NOUN
ctmj-149	141	41	.	.	PUNCT
ctmj-149	142	1	moreover	moreover	ADV
ctmj-149	142	2	,	,	PUNCT
ctmj-149	142	3	menthol	menthol	NOUN
ctmj-149	142	4	downregulated	downregulate	VERB
ctmj-149	142	5	the	the	DET
ctmj-149	142	6	teer	teer	NOUN
ctmj-149	142	7	,	,	PUNCT
ctmj-149	142	8	which	which	PRON
ctmj-149	142	9	verified	verify	VERB
ctmj-149	142	10	the	the	DET
ctmj-149	142	11	relationship	relationship	NOUN
ctmj-149	142	12	between	between	ADP
ctmj-149	142	13	tj	tj	NOUN
ctmj-149	142	14	and	and	CCONJ
ctmj-149	142	15	teer	teer	NOUN
ctmj-149	142	16	value	value	NOUN
ctmj-149	142	17	,	,	PUNCT
ctmj-149	142	18	and	and	CCONJ
ctmj-149	142	19	contributed	contribute	VERB
ctmj-149	142	20	to	to	ADP
ctmj-149	142	21	opening	open	VERB
ctmj-149	142	22	the	the	DET
ctmj-149	142	23	barrier	barrier	NOUN
ctmj-149	142	24	to	to	ADP
ctmj-149	142	25	in	in	ADP
ctmj-149	142	26	crease	crease	NOUN
ctmj-149	142	27	paracellular	paracellular	ADJ
ctmj-149	142	28	transport	transport	NOUN
ctmj-149	142	29	.	.	PUNCT
ctmj-149	143	1	this	this	DET
ctmj-149	143	2	study	study	NOUN
ctmj-149	143	3	was	be	AUX
ctmj-149	143	4	carried	carry	VERB
ctmj-149	143	5	out	out	ADP
ctmj-149	143	6	to	to	PART
ctmj-149	143	7	advance	advance	VERB
ctmj-149	143	8	our	our	PRON
ctmj-149	143	9	understanding	understanding	NOUN
ctmj-149	143	10	of	of	ADP
ctmj-149	143	11	the	the	DET
ctmj-149	143	12	effect	effect	NOUN
ctmj-149	143	13	of	of	ADP
ctmj-149	143	14	puerarin	puerarin	NOUN
ctmj-149	143	15	,	,	PUNCT
ctmj-149	143	16	paeoniflorin	paeoniflorin	NOUN
ctmj-149	143	17	,	,	PUNCT
ctmj-149	143	18	and	and	CCONJ
ctmj-149	143	19	menthol	menthol	NOUN
ctmj-149	143	20	on	on	ADP
ctmj-149	143	21	the	the	DET
ctmj-149	143	22	bbb	bbb	NOUN
ctmj-149	143	23	and	and	CCONJ
ctmj-149	143	24	provide	provide	VERB
ctmj-149	143	25	insight	insight	NOUN
ctmj-149	143	26	into	into	ADP
ctmj-149	143	27	how	how	SCONJ
ctmj-149	143	28	tongqiaosanyu	tongqiaosanyu	NOUN
ctmj-149	143	29	affects	affect	VERB
ctmj-149	143	30	tj	tj	NOUN
ctmj-149	143	31	structure	structure	NOUN
ctmj-149	143	32	and	and	CCONJ
ctmj-149	143	33	function	function	NOUN
ctmj-149	143	34	.	.	PUNCT
ctmj-149	144	1	the	the	DET
ctmj-149	144	2	study	study	NOUN
ctmj-149	144	3	also	also	ADV
ctmj-149	144	4	helps	help	VERB
ctmj-149	144	5	explain	explain	VERB
ctmj-149	144	6	the	the	DET
ctmj-149	144	7	interaction	interaction	NOUN
ctmj-149	144	8	of	of	ADP
ctmj-149	144	9	drugs	drug	NOUN
ctmj-149	144	10	in	in	ADP
ctmj-149	144	11	a	a	DET
ctmj-149	144	12	multicomponent	multicomponent	ADJ
ctmj-149	144	13	herbal	herbal	ADJ
ctmj-149	144	14	prescription	prescription	NOUN
ctmj-149	144	15	.	.	PUNCT
ctmj-149	145	1	references	reference	NOUN
ctmj-149	145	2	1	1	NUM
ctmj-149	145	3	.	.	PUNCT
ctmj-149	145	4	yliperttula	yliperttula	PROPN
ctmj-149	145	5	m.	m.	PROPN
ctmj-149	145	6	,	,	PUNCT
ctmj-149	145	7	del	del	PROPN
ctmj-149	145	8	amo	amo	PROPN
ctmj-149	145	9	em	em	PRON
ctmj-149	145	10	.	.	PUNCT
ctmj-149	145	11	,	,	PUNCT
ctmj-149	145	12	urtti	urtti	PROPN
ctmj-149	145	13	a.	a.	NOUN
ctmj-149	145	14	influence	influence	NOUN
ctmj-149	145	15	on	on	ADP
ctmj-149	145	16	pharmacokinetics	pharmacokinetic	NOUN
ctmj-149	145	17	by	by	ADP
ctmj-149	145	18	l	l	NOUN
ctmj-149	145	19	-	-	PUNCT
ctmj-149	145	20	type	type	NOUN
ctmj-149	145	21	amino	amino	NOUN
ctmj-149	145	22	acid	acid	NOUN
ctmj-149	145	23	transporters	transporter	NOUN
ctmj-149	145	24	lat1	lat1	NOUN
ctmj-149	145	25	and	and	CCONJ
ctmj-149	145	26	lat2	lat2	PROPN
ctmj-149	145	27	.	.	PUNCT
ctmj-149	146	1	european	european	PROPN
ctmj-149	146	2	journal	journal	PROPN
ctmj-149	146	3	of	of	ADP
ctmj-149	146	4	pharmaceutical	pharmaceutical	NOUN
ctmj-149	146	5	science	science	NOUN
ctmj-149	146	6	.	.	PUNCT
ctmj-149	147	1	2008;35:161–174	2008;35:161–174	NUM
ctmj-149	147	2	.	.	PUNCT
ctmj-149	148	1	2	2	NUM
ctmj-149	148	2	.	.	NOUN
ctmj-149	148	3	ohtsuki	ohtsuki	PROPN
ctmj-149	148	4	s	s	PROPN
ctmj-149	148	5	,	,	PUNCT
ctmj-149	148	6	terasaki	terasaki	PROPN
ctmj-149	148	7	t.	t.	PROPN
ctmj-149	148	8	the	the	DET
ctmj-149	148	9	blood	blood	NOUN
ctmj-149	148	10	-	-	PUNCT
ctmj-149	148	11	brain	brain	NOUN
ctmj-149	148	12	barrier	barrier	NOUN
ctmj-149	148	13	:	:	PUNCT
ctmj-149	148	14	a	a	DET
ctmj-149	148	15	supporting	support	VERB
ctmj-149	148	16	and	and	CCONJ
ctmj-149	148	17	protective	protective	ADJ
ctmj-149	148	18	interface	interface	NOUN
ctmj-149	148	19	for	for	ADP
ctmj-149	148	20	the	the	DET
ctmj-149	148	21	brain	brain	NOUN
ctmj-149	148	22	;	;	PUNCT
ctmj-149	148	23	the	the	DET
ctmj-149	148	24	role	role	NOUN
ctmj-149	148	25	of	of	ADP
ctmj-149	148	26	carrier	carrier	NOUN
ctmj-149	148	27	-	-	PUNCT
ctmj-149	148	28	mediated	mediate	VERB
ctmj-149	148	29	trans	trans	ADJ
ctmj-149	148	30	-	-	ADJ
ctmj-149	148	31	port	port	ADJ
ctmj-149	148	32	systems	system	NOUN
ctmj-149	148	33	;	;	PUNCT
ctmj-149	148	34	implications	implication	NOUN
ctmj-149	148	35	for	for	ADP
ctmj-149	148	36	the	the	DET
ctmj-149	148	37	development	development	NOUN
ctmj-149	148	38	and	and	CCONJ
ctmj-149	148	39	discovery	discovery	NOUN
ctmj-149	148	40	of	of	ADP
ctmj-149	148	41	drugs	drug	NOUN
ctmj-149	148	42	for	for	ADP
ctmj-149	148	43	the	the	DET
ctmj-149	148	44	central	central	ADJ
ctmj-149	148	45	nervous	nervous	ADJ
ctmj-149	148	46	system	system	NOUN
ctmj-149	148	47	.	.	PUNCT
ctmj-149	149	1	journal	journal	NOUN
ctmj-149	149	2	of	of	ADP
ctmj-149	149	3	pharmaceutical	pharmaceutical	NOUN
ctmj-149	149	4	research	research	NOUN
ctmj-149	149	5	,	,	PUNCT
ctmj-149	149	6	2007;24:1745–1758	2007;24:1745–1758	NOUN
ctmj-149	149	7	.	.	PUNCT
ctmj-149	150	1	citation	citation	NOUN
ctmj-149	150	2	:	:	PUNCT
ctmj-149	151	1	3	3	X
ctmj-149	151	2	.	.	X
ctmj-149	151	3	international	international	ADJ
ctmj-149	151	4	transporter	transporter	NOUN
ctmj-149	151	5	consortium	consortium	NOUN
ctmj-149	151	6	,	,	PUNCT
ctmj-149	151	7	huang	huang	PROPN
ctmj-149	151	8	sm	sm	PROPN
ctmj-149	151	9	,	,	PUNCT
ctmj-149	151	10	giacomini	giacomini	PROPN
ctmj-149	151	11	km	km	PROPN
ctmj-149	151	12	,	,	PUNCT
ctmj-149	151	13	et	et	PROPN
ctmj-149	151	14	al	al	PROPN
ctmj-149	151	15	.	.	PUNCT
ctmj-149	151	16	membrane	membrane	NOUN
ctmj-149	151	17	transporters	transporter	NOUN
ctmj-149	151	18	in	in	ADP
ctmj-149	151	19	drug	drug	NOUN
ctmj-149	151	20	development	development	NOUN
ctmj-149	151	21	.	.	PUNCT
ctmj-149	152	1	the	the	DET
ctmj-149	152	2	national	national	PROPN
ctmj-149	152	3	journal	journal	PROPN
ctmj-149	152	4	of	of	ADP
ctmj-149	152	5	drug	drug	NOUN
ctmj-149	152	6	discovery	discovery	PROPN
ctmj-149	152	7	2010	2010	NUM
ctmj-149	152	8	,	,	PUNCT
ctmj-149	152	9	9	9	NUM
ctmj-149	152	10	,	,	PUNCT
ctmj-149	152	11	215–236	215–236	NUM
ctmj-149	152	12	.	.	PUNCT
ctmj-149	153	1	the	the	DET
ctmj-149	153	2	blood	blood	NOUN
ctmj-149	153	3	-	-	PUNCT
ctmj-149	153	4	brain	brain	NOUN
ctmj-149	153	5	barrier	barrier	NOUN
ctmj-149	153	6	:	:	PUNCT
ctmj-149	153	7	structure	structure	NOUN
ctmj-149	153	8	and	and	CCONJ
ctmj-149	153	9	function	function	NOUN
ctmj-149	153	10	(	(	PUNCT
ctmj-149	153	11	abbott	abbott	PROPN
ctmj-149	153	12	,	,	PUNCT
ctmj-149	153	13	patabendige	patabendige	NOUN
ctmj-149	153	14	,	,	PUNCT
ctmj-149	153	15	dolman	dolman	PROPN
ctmj-149	153	16	,	,	PUNCT
ctmj-149	153	17	et	et	PROPN
ctmj-149	153	18	al	al	PROPN
ctmj-149	153	19	.	.	PROPN
ctmj-149	153	20	,	,	PUNCT
ctmj-149	153	21	2004	2004	NUM
ctmj-149	153	22	)	)	PUNCT
ctmj-149	153	23	.	.	PUNCT
ctmj-149	154	1	psychobiology	psychobiology	NOUN
ctmj-149	154	2	of	of	ADP
ctmj-149	154	3	disease	disease	NOUN
ctmj-149	154	4	.	.	PUNCT
ctmj-149	155	1	2009;37	2009;37	NUM
ctmj-149	155	2	:	:	PUNCT
ctmj-149	156	1	13–25	13–25	NUM
ctmj-149	156	2	.	.	PUNCT
ctmj-149	157	1	3	3	X
ctmj-149	157	2	.	.	NOUN
ctmj-149	157	3	vastag	vastag	PROPN
ctmj-149	157	4	m	m	PROPN
ctmj-149	157	5	,	,	PUNCT
ctmj-149	157	6	keseru	keseru	PROPN
ctmj-149	157	7	gm	gm	PROPN
ctmj-149	157	8	.	.	PUNCT
ctmj-149	158	1	current	current	ADJ
ctmj-149	158	2	in	in	ADP
ctmj-149	158	3	vitro	vitro	X
ctmj-149	158	4	and	and	CCONJ
ctmj-149	158	5	in	in	ADP
ctmj-149	158	6	silico	silico	NOUN
ctmj-149	158	7	models	model	NOUN
ctmj-149	158	8	of	of	ADP
ctmj-149	158	9	blood	blood	NOUN
ctmj-149	158	10	-	-	PUNCT
ctmj-149	158	11	brain	brain	NOUN
ctmj-149	158	12	barrier	barrier	NOUN
ctmj-149	158	13	penetration	penetration	NOUN
ctmj-149	158	14	:	:	PUNCT
ctmj-149	158	15	a	a	DET
ctmj-149	158	16	practical	practical	ADJ
ctmj-149	158	17	perspective	perspective	NOUN
ctmj-149	158	18	.	.	PUNCT
ctmj-149	159	1	drug	drug	NOUN
ctmj-149	159	2	discovery	discovery	PROPN
ctmj-149	159	3	and	and	CCONJ
ctmj-149	159	4	clinical	clinical	ADJ
ctmj-149	159	5	practice	practice	NOUN
ctmj-149	159	6	.	.	PUNCT
ctmj-149	160	1	2009;12:115–124	2009;12:115–124	X
ctmj-149	160	2	.	.	PUNCT
ctmj-149	161	1	yang	yang	PROPN
ctmj-149	161	2	q	q	PROPN
ctmj-149	161	3	,	,	PUNCT
ctmj-149	161	4	rager	rager	NOUN
ctmj-149	161	5	jd	jd	PROPN
ctmj-149	161	6	,	,	PUNCT
ctmj-149	161	7	weinstein	weinstein	PROPN
ctmj-149	161	8	k	k	PROPN
ctmj-149	161	9	,	,	PUNCT
ctmj-149	161	10	et	et	PROPN
ctmj-149	161	11	al	al	PROPN
ctmj-149	161	12	.	.	PROPN
ctmj-149	161	13	assessment	assessment	NOUN
ctmj-149	161	14	of	of	ADP
ctmj-149	161	15	the	the	DET
ctmj-149	161	16	blood	blood	NOUN
ctmj-149	161	17	-	-	PUNCT
ctmj-149	161	18	brain	brain	NOUN
ctmj-149	161	19	barrier	barrier	NOUN
ctmj-149	161	20	permeability	permeability	NOUN
ctmj-149	161	21	using	use	VERB
ctmj-149	161	22	the	the	DET
ctmj-149	161	23	mdr	mdr	PROPN
ctmj-149	161	24	-	-	PROPN
ctmj-149	161	25	mdck	mdck	PROPN
ctmj-149	161	26	cell	cell	NOUN
ctmj-149	161	27	line	line	NOUN
ctmj-149	161	28	.	.	PUNCT
ctmj-149	162	1	international	international	ADJ
ctmj-149	162	2	journal	journal	PROPN
ctmj-149	162	3	of	of	ADP
ctmj-149	162	4	pharmaceutical	pharmaceutical	NOUN
ctmj-149	162	5	sciences	science	NOUN
ctmj-149	162	6	,	,	PUNCT
ctmj-149	162	7	2005	2005	NUM
ctmj-149	162	8	,	,	PUNCT
ctmj-149	162	9	288	288	NUM
ctmj-149	162	10	:	:	PUNCT
ctmj-149	162	11	349–359	349–359	NUM
ctmj-149	162	12	.	.	PUNCT
ctmj-149	163	1	7	7	X
ctmj-149	163	2	.	.	X
ctmj-149	163	3	decjana	decjana	PROPN
ctmj-149	163	4	e.	e.	PROPN
ctmj-149	163	5	endothelial	endothelial	PROPN
ctmj-149	163	6	cell	cell	NOUN
ctmj-149	163	7	-	-	PUNCT
ctmj-149	163	8	cell	cell	NOUN
ctmj-149	163	9	junctions	junction	NOUN
ctmj-149	163	10	:	:	PUNCT
ctmj-149	163	11	joyous	joyous	ADJ
ctmj-149	163	12	companions	companion	NOUN
ctmj-149	163	13	.	.	PUNCT
ctmj-149	164	1	natural	natural	ADJ
ctmj-149	164	2	reviews	review	NOUN
ctmj-149	164	3	in	in	ADP
ctmj-149	164	4	cell	cell	NOUN
ctmj-149	164	5	biology	biology	NOUN
ctmj-149	164	6	,	,	PUNCT
ctmj-149	164	7	2004	2004	NUM
ctmj-149	164	8	,	,	PUNCT
ctmj-149	164	9	5	5	NUM
ctmj-149	164	10	,	,	PUNCT
ctmj-149	164	11	261–270	261–270	NUM
ctmj-149	164	12	.	.	PUNCT
ctmj-149	165	1	8	8	NUM
ctmj-149	165	2	.	.	X
ctmj-149	165	3	cereijido	cereijido	PROPN
ctmj-149	165	4	m	m	PROPN
ctmj-149	165	5	,	,	PUNCT
ctmj-149	165	6	and	and	CCONJ
ctmj-149	165	7	anderson	anderson	PROPN
ctmj-149	165	8	jm	jm	PROPN
ctmj-149	165	9	.	.	PROPN
ctmj-149	165	10	introduction	introduction	NOUN
ctmj-149	165	11	to	to	ADP
ctmj-149	165	12	tight	tight	ADJ
ctmj-149	165	13	junctions	junction	NOUN
ctmj-149	165	14	:	:	PUNCT
ctmj-149	165	15	the	the	DET
ctmj-149	165	16	development	development	NOUN
ctmj-149	165	17	of	of	ADP
ctmj-149	165	18	concepts	concept	NOUN
ctmj-149	165	19	around	around	ADP
ctmj-149	165	20	them	they	PRON
ctmj-149	165	21	.	.	PUNCT
ctmj-149	166	1	press	press	PROPN
ctmj-149	166	2	,	,	PUNCT
ctmj-149	166	3	boca	boca	PROPN
ctmj-149	166	4	raton	raton	PROPN
ctmj-149	166	5	,	,	PUNCT
ctmj-149	166	6	fl	fl	PROPN
ctmj-149	166	7	,	,	PUNCT
ctmj-149	166	8	2001	2001	NUM
ctmj-149	166	9	.	.	PUNCT
ctmj-149	167	1	9	9	X
ctmj-149	167	2	.	.	X
ctmj-149	167	3	gumbiner	gumbiner	PROPN
ctmj-149	167	4	b.	b.	PROPN
ctmj-149	167	5	overcoming	overcome	VERB
ctmj-149	167	6	the	the	DET
ctmj-149	167	7	obstacle	obstacle	NOUN
ctmj-149	167	8	of	of	ADP
ctmj-149	167	9	the	the	DET
ctmj-149	167	10	tight	tight	ADJ
ctmj-149	167	11	intersection	intersection	NOUN
ctmj-149	167	12	.	.	PUNCT
ctmj-149	168	1	jameson	jameson	PROPN
ctmj-149	168	2	et	et	PROPN
ctmj-149	168	3	al	al	PROPN
ctmj-149	168	4	.	.	PROPN
ctmj-149	168	5	,	,	PUNCT
ctmj-149	168	6	1993	1993	NUM
ctmj-149	168	7	,	,	PUNCT
ctmj-149	168	8	journal	journal	NOUN
ctmj-149	168	9	of	of	ADP
ctmj-149	168	10	cell	cell	NOUN
ctmj-149	168	11	biology	biology	NOUN
ctmj-149	168	12	,	,	PUNCT
ctmj-149	168	13	123	123	NUM
ctmj-149	168	14	:	:	SYM
ctmj-149	168	15	1631–1633	1631–1633	NUM
ctmj-149	168	16	.	.	PUNCT
ctmj-149	169	1	yokoyama	yokoyama	PROPN
ctmj-149	169	2	s	s	PROPN
ctmj-149	169	3	,	,	PUNCT
ctmj-149	169	4	furuse	furuse	NOUN
ctmj-149	169	5	m	m	PROPN
ctmj-149	169	6	,	,	PUNCT
ctmj-149	169	7	and	and	CCONJ
ctmj-149	169	8	itoh	itoh	PROPN
ctmj-149	169	9	m.	m.	NOUN
ctmj-149	169	10	10	10	NUM
ctmj-149	169	11	.	.	PUNCT
ctmj-149	169	12	strands	strand	NOUN
ctmj-149	169	13	with	with	ADP
ctmj-149	169	14	several	several	ADJ
ctmj-149	169	15	functions	function	NOUN
ctmj-149	169	16	bound	bind	VERB
ctmj-149	169	17	together	together	ADV
ctmj-149	169	18	in	in	ADP
ctmj-149	169	19	a	a	DET
ctmj-149	169	20	certain	certain	ADJ
ctmj-149	169	21	configuration	configuration	NOUN
ctmj-149	169	22	.	.	PUNCT
ctmj-149	170	1	science	science	NOUN
ctmj-149	170	2	translational	translational	ADJ
ctmj-149	170	3	medicine	medicine	NOUN
ctmj-149	170	4	.	.	PUNCT
ctmj-149	171	1	2001;2:285–293	2001;2:285–293	NUM
ctmj-149	171	2	.	.	PUNCT
ctmj-149	172	1	eleven	eleven	NUM
ctmj-149	172	2	.	.	PUNCT
ctmj-149	172	3	sawada	sawada	PROPN
ctmj-149	172	4	,	,	PUNCT
ctmj-149	172	5	murata	murata	PROPN
ctmj-149	172	6	,	,	PUNCT
ctmj-149	172	7	kikuchi	kikuchi	PROPN
ctmj-149	172	8	,	,	PUNCT
ctmj-149	172	9	et	et	PROPN
ctmj-149	172	10	al	al	PROPN
ctmj-149	172	11	.	.	PUNCT
ctmj-149	173	1	human	human	ADJ
ctmj-149	173	2	illness	illness	NOUN
ctmj-149	173	3	and	and	CCONJ
ctmj-149	173	4	narrow	narrow	ADJ
ctmj-149	173	5	connections	connection	NOUN
ctmj-149	173	6	.	.	PUNCT
ctmj-149	174	1	the	the	DET
ctmj-149	174	2	medical	medical	ADJ
ctmj-149	174	3	electron	electron	NOUN
ctmj-149	174	4	microscopy	microscopy	PROPN
ctmj-149	174	5	journal	journal	PROPN
ctmj-149	174	6	published	publish	VERB
ctmj-149	174	7	an	an	DET
ctmj-149	174	8	article	article	NOUN
ctmj-149	174	9	in	in	ADP
ctmj-149	174	10	2003	2003	NUM
ctmj-149	174	11	with	with	ADP
ctmj-149	174	12	the	the	DET
ctmj-149	174	13	doi	doi	NOUN
ctmj-149	174	14	number	number	NOUN
ctmj-149	174	15	36:147–156	36:147–156	PROPN
ctmj-149	174	16	.	.	PUNCT
ctmj-149	175	1	schaneeberger	schaneeberger	PROPN
ctmj-149	175	2	ee	ee	PROPN
ctmj-149	175	3	and	and	CCONJ
ctmj-149	175	4	lynch	lynch	PROPN
ctmj-149	175	5	rd	rd	PROPN
ctmj-149	175	6	.	.	PROPN
ctmj-149	175	7	12	12	NUM
ctmj-149	175	8	.	.	PUNCT
ctmj-149	176	1	the	the	DET
ctmj-149	176	2	tight	tight	ADJ
ctmj-149	176	3	junction	junction	NOUN
ctmj-149	176	4	is	be	AUX
ctmj-149	176	5	a	a	DET
ctmj-149	176	6	complex	complex	NOUN
ctmj-149	176	7	with	with	ADP
ctmj-149	176	8	several	several	ADJ
ctmj-149	176	9	functions	function	NOUN
ctmj-149	176	10	.	.	PUNCT
ctmj-149	177	1	journal	journal	NOUN
ctmj-149	177	2	of	of	ADP
ctmj-149	177	3	applied	apply	VERB
ctmj-149	177	4	physiology	physiology	NOUN
ctmj-149	177	5	and	and	CCONJ
ctmj-149	177	6	cell	cell	NOUN
ctmj-149	177	7	biology	biology	NOUN
ctmj-149	177	8	.	.	PUNCT
ctmj-149	178	1	2004;286:1213–1228	2004;286:1213–1228	NUM
ctmj-149	178	2	.	.	PUNCT
ctmj-149	179	1	13	13	NUM
ctmj-149	179	2	.	.	PUNCT
ctmj-149	179	3	rukkle	rukkle	PROPN
ctmj-149	179	4	ea	ea	PROPN
ctmj-149	179	5	,	,	PUNCT
ctmj-149	179	6	mu	mu	PROPN
ctmj-149	179	7	d.	d.	PROPN
ctmj-149	179	8	tight	tight	ADJ
ctmj-149	179	9	junction	junction	NOUN
ctmj-149	179	10	proteins	protein	NOUN
ctmj-149	179	11	:	:	PUNCT
ctmj-149	179	12	a	a	DET
ctmj-149	179	13	pathway	pathway	NOUN
ctmj-149	179	14	from	from	ADP
ctmj-149	179	15	cancer	cancer	NOUN
ctmj-149	179	16	to	to	ADP
ctmj-149	179	17	physiological	physiological	ADJ
ctmj-149	179	18	barriers	barrier	NOUN
ctmj-149	179	19	.	.	PUNCT
ctmj-149	180	1	lett	lett	PROPN
ctmj-149	180	2	.	.	PUNCT
ctmj-149	181	1	cancer	cancer	PROPN
ctmj-149	181	2	2013;337:41–48	2013;337:41–48	PROPN
ctmj-149	181	3	.	.	PUNCT
ctmj-149	182	1	citation	citation	NOUN
ctmj-149	182	2	:	:	PUNCT
ctmj-149	182	3	collares	collare	NOUN
ctmj-149	182	4	-	-	PUNCT
ctmj-149	182	5	buzato	buzato	ADJ
ctmj-149	182	6	cb	cb	PROPN
ctmj-149	182	7	,	,	PUNCT
ctmj-149	182	8	jepson	jepson	PROPN
ctmj-149	182	9	ma	ma	PROPN
ctmj-149	182	10	,	,	PUNCT
ctmj-149	182	11	simmons	simmons	PROPN
ctmj-149	182	12	nl	nl	PROPN
ctmj-149	182	13	,	,	PUNCT
ctmj-149	182	14	hirst	hirst	PROPN
ctmj-149	182	15	bh	bh	PROPN
ctmj-149	182	16	.	.	PROPN
ctmj-149	182	17	14	14	NUM
ctmj-149	182	18	.	.	PUNCT
ctmj-149	183	1	in	in	ADP
ctmj-149	183	2	mdck	mdck	PROPN
ctmj-149	183	3	epithelia	epithelia	PROPN
ctmj-149	183	4	,	,	PUNCT
ctmj-149	183	5	increased	increase	VERB
ctmj-149	183	6	tyrosine	tyrosine	NOUN
ctmj-149	183	7	phosphorylation	phosphorylation	NOUN
ctmj-149	183	8	disrupts	disrupt	VERB
ctmj-149	183	9	paracellular	paracellular	ADJ
ctmj-149	183	10	barrier	barrier	NOUN
ctmj-149	183	11	function	function	NOUN
ctmj-149	183	12	and	and	CCONJ
ctmj-149	183	13	redistributes	redistribute	VERB
ctmj-149	183	14	adherens	adheren	NOUN
ctmj-149	183	15	junction	junction	NOUN
ctmj-149	183	16	and	and	CCONJ
ctmj-149	183	17	tight	tight	ADJ
ctmj-149	183	18	junction	junction	NOUN
ctmj-149	183	19	proteins	protein	NOUN
ctmj-149	183	20	.	.	PUNCT
ctmj-149	184	1	chapter	chapter	NOUN
ctmj-149	184	2	15	15	NUM
ctmj-149	184	3	of	of	ADP
ctmj-149	184	4	the	the	DET
ctmj-149	184	5	european	european	PROPN
ctmj-149	184	6	journal	journal	PROPN
ctmj-149	184	7	of	of	ADP
ctmj-149	184	8	cell	cell	NOUN
ctmj-149	184	9	biology	biology	NOUN
ctmj-149	184	10	(	(	PUNCT
ctmj-149	184	11	volume	volume	NOUN
ctmj-149	184	12	76	76	NUM
ctmj-149	184	13	,	,	PUNCT
ctmj-149	184	14	issue	issue	NOUN
ctmj-149	184	15	92).citi	92).citi	NUM
ctmj-149	184	16	s.	s.	PROPN
ctmj-149	184	17	,	,	PUNCT
ctmj-149	184	18	rodriguez	rodriguez	NOUN
ctmj-149	184	19	-	-	PUNCT
ctmj-149	184	20	boulan	boulan	PROPN
ctmj-149	184	21	e.	e.	PROPN
ctmj-149	184	22	,	,	PUNCT
ctmj-149	184	23	denisenko	denisenko	PROPN
ctmj-149	184	24	n.	n.	PROPN
ctmj-149	184	25	,	,	PUNCT
ctmj-149	184	26	nigam	nigam	PROPN
ctmj-149	184	27	sk	sk	PROPN
ctmj-149	184	28	.	.	PUNCT
ctmj-149	185	1	cells	cell	NOUN
ctmj-149	185	2	of	of	ADP
ctmj-149	185	3	cultured	cultured	ADJ
ctmj-149	185	4	renal	renal	ADJ
ctmj-149	185	5	epithelial	epithelial	ADJ
ctmj-149	185	6	(	(	PUNCT
ctmj-149	185	7	mdck	mdck	X
ctmj-149	185	8	)	)	PUNCT
ctmj-149	185	9	play	play	VERB
ctmj-149	185	10	an	an	DET
ctmj-149	185	11	important	important	ADJ
ctmj-149	185	12	part	part	NOUN
ctmj-149	185	13	in	in	ADP
ctmj-149	185	14	the	the	DET
ctmj-149	185	15	formation	formation	NOUN
ctmj-149	185	16	of	of	ADP
ctmj-149	185	17	tight	tight	ADJ
ctmj-149	185	18	junctions	junction	NOUN
ctmj-149	185	19	via	via	ADP
ctmj-149	185	20	phosphorylation	phosphorylation	NOUN
ctmj-149	185	21	.	.	PUNCT
ctmj-149	186	1	the	the	DET
ctmj-149	186	2	publication	publication	NOUN
ctmj-149	186	3	cited	cite	VERB
ctmj-149	186	4	is	be	AUX
ctmj-149	186	5	biochem	biochem	PROPN
ctmj-149	186	6	biophys	biophy	NOUN
ctmj-149	186	7	res	re	NOUN
ctmj-149	186	8	commun	commun	PROPN
ctmj-149	186	9	.	.	PUNCT
ctmj-149	187	1	(	(	PUNCT
ctmj-149	187	2	1991	1991	NUM
ctmj-149	187	3	,	,	PUNCT
ctmj-149	187	4	181:548–553	181:548–553	NUM
ctmj-149	187	5	)	)	PUNCT
ctmj-149	187	6	.	.	PUNCT
ctmj-149	188	1	a	a	DET
ctmj-149	188	2	group	group	NOUN
ctmj-149	188	3	of	of	ADP
ctmj-149	188	4	researchers	researcher	NOUN
ctmj-149	188	5	included	include	VERB
ctmj-149	188	6	gonzálezmariscal	gonzálezmariscal	ADJ
ctmj-149	188	7	,	,	PUNCT
ctmj-149	188	8	islas	islas	PROPN
ctmj-149	188	9	,	,	PUNCT
ctmj-149	188	10	and	and	CCONJ
ctmj-149	188	11	contreras	contreras	X
ctmj-149	188	12	(	(	PUNCT
ctmj-149	188	13	16	16	NUM
ctmj-149	188	14	)	)	PUNCT
ctmj-149	188	15	.	.	PUNCT
ctmj-149	189	1	determination	determination	NOUN
ctmj-149	189	2	of	of	ADP
ctmj-149	189	3	zo-1	zo-1	NOUN
ctmj-149	189	4	's	's	PART
ctmj-149	189	5	molecular	molecular	ADJ
ctmj-149	189	6	properties	property	NOUN
ctmj-149	189	7	in	in	ADP
ctmj-149	189	8	mdck	mdck	PROPN
ctmj-149	189	9	cells	cell	NOUN
ctmj-149	189	10	:	:	PUNCT
ctmj-149	189	11	a	a	DET
ctmj-149	189	12	tight	tight	ADJ
ctmj-149	189	13	junction	junction	NOUN
ctmj-149	189	14	protein	protein	NOUN
ctmj-149	189	15	.	.	PUNCT
ctmj-149	190	1	science	science	NOUN
ctmj-149	190	2	.	.	PUNCT
ctmj-149	191	1	1999	1999	NUM
ctmj-149	191	2	,	,	PUNCT
ctmj-149	191	3	248	248	NUM
ctmj-149	191	4	:	:	PUNCT
ctmj-149	192	1	97–109	97–109	NUM
ctmj-149	192	2	.	.	PUNCT
ctmj-149	193	1	17	17	NUM
ctmj-149	193	2	.	.	PUNCT
ctmj-149	194	1	kim	kim	PROPN
ctmj-149	194	2	h.	h.	PROPN
ctmj-149	194	3	herbs	herb	NOUN
ctmj-149	194	4	with	with	ADP
ctmj-149	194	5	neuroprotective	neuroprotective	ADJ
ctmj-149	194	6	properties	property	NOUN
ctmj-149	194	7	used	use	VERB
ctmj-149	194	8	in	in	ADP
ctmj-149	194	9	traditional	traditional	ADJ
ctmj-149	194	10	eastern	eastern	ADJ
ctmj-149	194	11	medicine	medicine	NOUN
ctmj-149	194	12	for	for	ADP
ctmj-149	194	13	stroke	stroke	NOUN
ctmj-149	194	14	treatment	treatment	NOUN
ctmj-149	194	15	.	.	PUNCT
ctmj-149	195	1	injectable	injectable	ADJ
ctmj-149	195	2	puserarin	puserarin	NOUN
ctmj-149	195	3	for	for	ADP
ctmj-149	195	4	unstable	unstable	ADJ
ctmj-149	195	5	angina	angina	NOUN
ctmj-149	195	6	pectoris	pectoris	PROPN
ctmj-149	195	7	.	.	PUNCT
ctmj-149	196	1	neurology	neurology	NOUN
ctmj-149	196	2	research	research	NOUN
ctmj-149	196	3	.	.	PUNCT
ctmj-149	197	1	2005;27:287	2005;27:287	X
ctmj-149	197	2	.	.	NOUN
ctmj-149	198	1	18	18	NUM
ctmj-149	198	2	.	.	PUNCT
ctmj-149	199	1	wang	wang	PROPN
ctmj-149	199	2	q	q	PROPN
ctmj-149	199	3	,	,	PUNCT
ctmj-149	199	4	wu	wu	PROPN
ctmj-149	199	5	t	t	PROPN
ctmj-149	199	6	,	,	PUNCT
ctmj-149	199	7	chen	chen	PROPN
ctmj-149	199	8	x	x	PROPN
ctmj-149	199	9	,	,	PUNCT
ctmj-149	199	10	et	et	PROPN
ctmj-149	199	11	al	al	PROPN
ctmj-149	199	12	.	.	PROPN
ctmj-149	199	13	published	publish	VERB
ctmj-149	199	14	in	in	ADP
ctmj-149	199	15	chinese	chinese	PROPN
ctmj-149	199	16	as	as	ADP
ctmj-149	199	17	cochrane	cochrane	PROPN
ctmj-149	199	18	database	database	PROPN
ctmj-149	199	19	syst	syst	PROPN
ctmj-149	199	20	rev	rev	PROPN
ctmj-149	199	21	.	.	PUNCT
ctmj-149	200	1	2006;19:4196	2006;19:4196	NUM
ctmj-149	200	2	.	.	PROPN
ctmj-149	200	3	19	19	NUM
ctmj-149	200	4	wang	wang	PROPN
ctmj-149	200	5	jw	jw	PROPN
ctmj-149	200	6	,	,	PUNCT
ctmj-149	200	7	cong	cong	NOUN
ctmj-149	200	8	zx	zx	NUM
ctmj-149	200	9	,	,	PUNCT
ctmj-149	200	10	and	and	CCONJ
ctmj-149	200	11	wang	wang	PROPN
ctmj-149	200	12	hd	hd	PROPN
ctmj-149	200	13	.	.	PROPN
ctmj-149	200	14	puerarin	puerarin	NOUN
ctmj-149	200	15	reduces	reduce	VERB
ctmj-149	200	16	oxidative	oxidative	ADJ
ctmj-149	200	17	stress	stress	NOUN
ctmj-149	200	18	after	after	ADP
ctmj-149	200	19	a	a	DET
ctmj-149	200	20	traumatic	traumatic	ADJ
ctmj-149	200	21	brain	brain	NOUN
ctmj-149	200	22	damage	damage	NOUN
ctmj-149	200	23	model	model	NOUN
ctmj-149	200	24	in	in	ADP
ctmj-149	200	25	rats	rat	NOUN
ctmj-149	200	26	.	.	PUNCT
ctmj-149	201	1	journal	journal	NOUN
ctmj-149	201	2	of	of	ADP
ctmj-149	201	3	the	the	DET
ctmj-149	201	4	american	american	ADJ
ctmj-149	201	5	society	society	NOUN
ctmj-149	201	6	for	for	ADP
ctmj-149	201	7	surgery	surgery	NOUN
ctmj-149	201	8	,	,	PUNCT
ctmj-149	201	9	volume	volume	NOUN
ctmj-149	201	10	186	186	NUM
ctmj-149	201	11	,	,	PUNCT
ctmj-149	201	12	pages	page	NOUN
ctmj-149	201	13	328–337	328–337	NUM
ctmj-149	201	14	,	,	PUNCT
ctmj-149	201	15	2014	2014	NUM
ctmj-149	201	16	.	.	PUNCT
ctmj-149	202	1	presenting	present	VERB
ctmj-149	202	2	the	the	DET
ctmj-149	202	3	work	work	NOUN
ctmj-149	202	4	of	of	ADP
ctmj-149	202	5	xia	xia	PROPN
ctmj-149	202	6	sm	sm	PROPN
ctmj-149	202	7	,	,	PUNCT
ctmj-149	202	8	cheng	cheng	PROPN
ctmj-149	202	9	dy	dy	PROPN
ctmj-149	202	10	,	,	PUNCT
ctmj-149	202	11	and	and	CCONJ
ctmj-149	202	12	hang	hang	VERB
ctmj-149	202	13	xm	xm	PROPN
ctmj-149	202	14	.	.	PUNCT
ctmj-149	203	1	an	an	DET
ctmj-149	203	2	approach	approach	NOUN
ctmj-149	203	3	to	to	ADP
ctmj-149	203	4	pharmacokinetic	pharmacokinetic	ADJ
ctmj-149	203	5	investigation	investigation	NOUN
ctmj-149	203	6	including	include	VERB
ctmj-149	203	7	the	the	DET
ctmj-149	203	8	sensitive	sensitive	ADJ
ctmj-149	203	9	liquid	liquid	ADJ
ctmj-149	203	10	chromatography	chromatography	NOUN
ctmj-149	203	11	tandem	tandem	NOUN
ctmj-149	203	12	mass	mass	ADJ
ctmj-149	203	13	spectrometry	spectrometry	NOUN
ctmj-149	203	14	technique	technique	NOUN
ctmj-149	203	15	for	for	ADP
ctmj-149	203	16	the	the	DET
ctmj-149	203	17	detection	detection	NOUN
ctmj-149	203	18	of	of	ADP
ctmj-149	203	19	paeoniflorin	paeoniflorin	NOUN
ctmj-149	203	20	in	in	ADP
ctmj-149	203	21	rat	rat	NOUN
ctmj-149	203	22	brain	brain	NOUN
ctmj-149	203	23	has	have	AUX
ctmj-149	203	24	been	be	AUX
ctmj-149	203	25	developed	develop	VERB
ctmj-149	203	26	and	and	CCONJ
ctmj-149	203	27	validated	validate	VERB
ctmj-149	203	28	.	.	PUNCT
ctmj-149	204	1	the	the	DET
ctmj-149	204	2	citation	citation	NOUN
ctmj-149	204	3	is	be	AUX
ctmj-149	204	4	from	from	ADP
ctmj-149	204	5	the	the	DET
ctmj-149	204	6	journal	journal	NOUN
ctmj-149	204	7	of	of	ADP
ctmj-149	204	8	chromatography	chromatography	NOUN
ctmj-149	204	9	,	,	PUNCT
ctmj-149	204	10	section	section	NOUN
ctmj-149	204	11	b	b	PROPN
ctmj-149	204	12	,	,	PUNCT
ctmj-149	204	13	volume	volume	NOUN
ctmj-149	204	14	857	857	NUM
ctmj-149	204	15	,	,	PUNCT
ctmj-149	204	16	pages	page	NOUN
ctmj-149	204	17	32–39	32–39	NUM
ctmj-149	204	18	,	,	PUNCT
ctmj-149	204	19	2007	2007	NUM
ctmj-149	204	20	.	.	PUNCT
ctmj-149	205	1	shin	shin	PROPN
ctmj-149	205	2	mf	mf	PROPN
ctmj-149	205	3	,	,	PUNCT
ctmj-149	205	4	li	li	PROPN
ctmj-149	205	5	xm	xm	PROPN
ctmj-149	205	6	,	,	PUNCT
ctmj-149	205	7	and	and	CCONJ
ctmj-149	205	8	shan	shan	PROPN
ctmj-149	205	9	qy	qy	PROPN
ctmj-149	205	10	are	be	AUX
ctmj-149	205	11	the	the	DET
ctmj-149	205	12	authors	author	NOUN
ctmj-149	205	13	of	of	ADP
ctmj-149	205	14	the	the	DET
ctmj-149	205	15	21st	21st	NOUN
ctmj-149	205	16	.	.	PUNCT
ctmj-149	206	1	studying	study	VERB
ctmj-149	206	2	the	the	DET
ctmj-149	206	3	pharmacological	pharmacological	ADJ
ctmj-149	206	4	effects	effect	NOUN
ctmj-149	206	5	and	and	CCONJ
ctmj-149	206	6	chemical	chemical	NOUN
ctmj-149	206	7	compositions	composition	NOUN
ctmj-149	206	8	of	of	ADP
ctmj-149	206	9	mentha	mentha	NOUN
ctmj-149	206	10	canadensis	canadensis	NOUN
ctmj-149	206	11	.	.	PUNCT
ctmj-149	207	1	the	the	DET
ctmj-149	207	2	chinese	chinese	ADJ
ctmj-149	207	3	journal	journal	PROPN
ctmj-149	207	4	of	of	ADP
ctmj-149	207	5	traditional	traditional	ADJ
ctmj-149	207	6	chinese	chinese	ADJ
ctmj-149	207	7	medicine	medicine	NOUN
ctmj-149	207	8	,	,	PUNCT
ctmj-149	207	9	2012	2012	NUM
ctmj-149	207	10	,	,	PUNCT
ctmj-149	207	11	7	7	NUM
ctmj-149	207	12	,	,	PUNCT
ctmj-149	207	13	1484–1486	1484–1486	NUM
ctmj-149	207	14	[	[	X
ctmj-149	207	15	chinese	chinese	X
ctmj-149	207	16	]	]	PUNCT
ctmj-149	207	17	.	.	PUNCT
ctmj-149	208	1	no	no	INTJ
ctmj-149	208	2	.	.	NOUN
ctmj-149	209	1	22	22	NUM
ctmj-149	209	2	:	:	PUNCT
ctmj-149	210	1	bing	bing	VERB
ctmj-149	210	2	y.	y.	NOUN
ctmj-149	210	3	examining	examine	VERB
ctmj-149	210	4	the	the	DET
ctmj-149	210	5	effects	effect	NOUN
ctmj-149	210	6	of	of	ADP
ctmj-149	210	7	tongqiaosan	tongqiaosan	NOUN
ctmj-149	210	8	's	's	PART
ctmj-149	210	9	effective	effective	ADJ
ctmj-149	210	10	constituent	constituent	NOUN
ctmj-149	210	11	on	on	ADP
ctmj-149	210	12	drug	drug	NOUN
ctmj-149	210	13	transport	transport	NOUN
ctmj-149	210	14	and	and	CCONJ
ctmj-149	210	15	compatibility	compatibility	NOUN
ctmj-149	210	16	using	use	VERB
ctmj-149	210	17	a	a	DET
ctmj-149	210	18	model	model	NOUN
ctmj-149	210	19	of	of	ADP
ctmj-149	210	20	normal	normal	ADJ
ctmj-149	210	21	and	and	CCONJ
ctmj-149	210	22	oxygen	oxygen	NOUN
ctmj-149	210	23	-	-	PUNCT
ctmj-149	210	24	glucose	glucose	NOUN
ctmj-149	210	25	deprivation	deprivation	NOUN
ctmj-149	210	26	at	at	ADP
ctmj-149	210	27	the	the	DET
ctmj-149	210	28	blood	blood	NOUN
ctmj-149	210	29	-	-	PUNCT
ctmj-149	210	30	brain	brain	NOUN
ctmj-149	210	31	barrier	barrier	NOUN
ctmj-149	210	32	[	[	X
ctmj-149	210	33	dissertation	dissertation	NOUN
ctmj-149	210	34	]	]	PUNCT
ctmj-149	210	35	.	.	PUNCT
ctmj-149	211	1	school	school	NOUN
ctmj-149	211	2	of	of	ADP
ctmj-149	211	3	traditional	traditional	ADJ
ctmj-149	211	4	chinese	chinese	ADJ
ctmj-149	211	5	medicine	medicine	NOUN
ctmj-149	211	6	in	in	ADP
ctmj-149	211	7	beijing	beijing	PROPN
ctmj-149	211	8	,	,	PUNCT
ctmj-149	211	9	china	china	PROPN
ctmj-149	211	10	.	.	PUNCT
ctmj-149	212	1	section	section	NOUN
ctmj-149	212	2	23	23	NUM
ctmj-149	212	3	:	:	PUNCT
ctmj-149	212	4	veszelka	veszelka	NOUN
ctmj-149	212	5	,	,	PUNCT
ctmj-149	212	6	kittel	kittel	PROPN
ctmj-149	212	7	,	,	PUNCT
ctmj-149	212	8	and	and	CCONJ
ctmj-149	212	9	deli	deli	NOUN
ctmj-149	212	10	.	.	PUNCT
ctmj-149	213	1	tools	tool	NOUN
ctmj-149	213	2	of	of	ADP
ctmj-149	213	3	simulating	simulate	VERB
ctmj-149	213	4	blood	blood	NOUN
ctmj-149	213	5	-	-	PUNCT
ctmj-149	213	6	brain	brain	NOUN
ctmj-149	213	7	barrier	barrier	NOUN
ctmj-149	213	8	penetrability	penetrability	NOUN
ctmj-149	213	9	.	.	PUNCT
ctmj-149	213	10	edited	edit	VERB
ctmj-149	213	11	by	by	ADP
ctmj-149	213	12	tihanyi	tihanyi	PROPN
ctmj-149	213	13	k	k	PROPN
ctmj-149	213	14	and	and	CCONJ
ctmj-149	213	15	vastag	vastag	ADJ
ctmj-149	213	16	m.	m.	NOUN
ctmj-149	213	17	drugs	drug	NOUN
ctmj-149	213	18	and	and	CCONJ
ctmj-149	213	19	drug	drug	NOUN
ctmj-149	213	20	candidates	candidate	NOUN
ctmj-149	213	21	:	:	PUNCT
ctmj-149	213	22	substance	substance	NOUN
ctmj-149	213	23	solubility	solubility	NOUN
ctmj-149	213	24	,	,	PUNCT
ctmj-149	213	25	administration	administration	NOUN
ctmj-149	213	26	,	,	PUNCT
ctmj-149	213	27	and	and	CCONJ
ctmj-149	213	28	adverse	adverse	ADJ
ctmj-149	213	29	drug	drug	NOUN
ctmj-149	213	30	reactions	reaction	NOUN
ctmj-149	213	31	.	.	PUNCT
ctmj-149	214	1	publisher	publisher	NOUN
ctmj-149	214	2	:	:	PUNCT
ctmj-149	214	3	bentham	bentham	PROPN
ctmj-149	214	4	science	science	NOUN
ctmj-149	214	5	publishers	publisher	NOUN
ctmj-149	214	6	;	;	PUNCT
ctmj-149	214	7	location	location	NOUN
ctmj-149	214	8	:	:	PUNCT
ctmj-149	214	9	sharjah	sharjah	PROPN
ctmj-149	214	10	,	,	PUNCT
ctmj-149	214	11	united	united	PROPN
ctmj-149	214	12	arab	arab	PROPN
ctmj-149	214	13	emirates	emirates	PROPN
ctmj-149	214	14	;	;	PUNCT
ctmj-149	214	15	pages	page	NOUN
ctmj-149	214	16	:	:	PUNCT
ctmj-149	214	17	166–188	166–188	NUM
ctmj-149	214	18	.	.	X
ctmj-149	215	1	24	24	NUM
ctmj-149	215	2	.	.	PUNCT
ctmj-149	216	1	gupta	gupta	PROPN
ctmj-149	216	2	a	a	PRON
ctmj-149	216	3	,	,	PUNCT
ctmj-149	216	4	syvaönen	syvaönen	PROPN
ctmj-149	216	5	s	s	PROPN
ctmj-149	216	6	,	,	PUNCT
ctmj-149	216	7	hammarlund	hammarlund	NOUN
ctmj-149	216	8	-	-	PUNCT
ctmj-149	216	9	udenaes	udenaes	PROPN
ctmj-149	216	10	m	m	PROPN
ctmj-149	216	11	,	,	PUNCT
ctmj-149	216	12	fride'n	fride'n	PROPN
ctmj-149	216	13	m.	m.	NOUN
ctmj-149	216	14	regarding	regard	VERB
ctmj-149	216	15	the	the	DET
ctmj-149	216	16	degree	degree	NOUN
ctmj-149	216	17	and	and	CCONJ
ctmj-149	216	18	pace	pace	NOUN
ctmj-149	216	19	of	of	ADP
ctmj-149	216	20	medication	medication	NOUN
ctmj-149	216	21	distribution	distribution	NOUN
ctmj-149	216	22	to	to	ADP
ctmj-149	216	23	the	the	DET
ctmj-149	216	24	brain	brain	NOUN
ctmj-149	216	25	.	.	PUNCT
ctmj-149	217	1	res	re	NOUN
ctmj-149	217	2	.	.	PUNCT
ctmj-149	218	1	in	in	ADP
ctmj-149	218	2	pharmacology	pharmacology	NOUN
ctmj-149	218	3	,	,	PUNCT
ctmj-149	218	4	2008	2008	NUM
ctmj-149	218	5	,	,	PUNCT
ctmj-149	218	6	25	25	NUM
ctmj-149	218	7	,	,	PUNCT
ctmj-149	218	8	1737–1750	1737–1750	NUM
ctmj-149	218	9	.	.	PUNCT
ctmj-149	219	1	abbott	abbott	PROPN
ctmj-149	219	2	,	,	PUNCT
ctmj-149	219	3	neal	neal	PROPN
ctmj-149	219	4	,	,	PUNCT
ctmj-149	219	5	and	and	CCONJ
ctmj-149	219	6	patabendige	patabendige	NOUN
ctmj-149	219	7	,	,	PUNCT
ctmj-149	219	8	akram	akram	PROPN
ctmj-149	219	9	.	.	PUNCT
ctmj-149	219	10	methods	method	NOUN
ctmj-149	219	11	for	for	ADP
ctmj-149	219	12	estimating	estimate	VERB
ctmj-149	219	13	the	the	DET
ctmj-149	219	14	likelihood	likelihood	NOUN
ctmj-149	219	15	that	that	SCONJ
ctmj-149	219	16	a	a	DET
ctmj-149	219	17	medicine	medicine	NOUN
ctmj-149	219	18	will	will	AUX
ctmj-149	219	19	penetrate	penetrate	VERB
ctmj-149	219	20	the	the	DET
ctmj-149	219	21	blood	blood	NOUN
ctmj-149	219	22	-	-	PUNCT
ctmj-149	219	23	brain	brain	NOUN
ctmj-149	219	24	barrier	barrier	NOUN
ctmj-149	219	25	and	and	CCONJ
ctmj-149	219	26	reach	reach	VERB
ctmj-149	219	27	the	the	DET
ctmj-149	219	28	head	head	NOUN
ctmj-149	219	29	.	.	PUNCT
ctmj-149	220	1	the	the	DET
ctmj-149	220	2	current	current	ADJ
ctmj-149	220	3	medication	medication	NOUN
ctmj-149	220	4	metabolism	metabolism	NOUN
ctmj-149	220	5	journal	journal	NOUN
ctmj-149	220	6	is	be	AUX
ctmj-149	220	7	curr	curr	PROPN
ctmj-149	220	8	drug	drug	NOUN
ctmj-149	220	9	metab	metab	NOUN
ctmj-149	220	10	.	.	PUNCT
ctmj-149	220	11	,	,	PUNCT
ctmj-149	220	12	2008	2008	NUM
ctmj-149	220	13	,	,	PUNCT
ctmj-149	220	14	9:901	9:901	NUM
ctmj-149	220	15	;	;	PUNCT
ctmj-149	220	16	910	910	NUM
ctmj-149	220	17	.	.	NOUN
ctmj-149	221	1	twenty	twenty	NUM
ctmj-149	221	2	-	-	PUNCT
ctmj-149	221	3	six	six	NUM
ctmj-149	221	4	.	.	PUNCT
ctmj-149	221	5	gumbleton	gumbleton	PROPN
ctmj-149	221	6	m	m	PROPN
ctmj-149	221	7	,	,	PUNCT
ctmj-149	221	8	audus	audus	PROPN
ctmj-149	221	9	kl	kl	PROPN
ctmj-149	221	10	.	.	PROPN
ctmj-149	221	11	progress	progress	NOUN
ctmj-149	221	12	and	and	CCONJ
ctmj-149	221	13	limits	limit	NOUN
ctmj-149	221	14	in	in	ADP
ctmj-149	221	15	the	the	DET
ctmj-149	221	16	use	use	NOUN
ctmj-149	221	17	of	of	ADP
ctmj-149	221	18	in	in	ADP
ctmj-149	221	19	vitro	vitro	X
ctmj-149	221	20	cell	cell	NOUN
ctmj-149	221	21	cultures	culture	NOUN
ctmj-149	221	22	to	to	PART
ctmj-149	221	23	act	act	VERB
ctmj-149	221	24	as	as	ADP
ctmj-149	221	25	a	a	DET
ctmj-149	221	26	permeability	permeability	NOUN
ctmj-149	221	27	test	test	NOUN
ctmj-149	221	28	for	for	ADP
ctmj-149	221	29	the	the	DET
ctmj-149	221	30	blood	blood	NOUN
ctmj-149	221	31	-	-	PUNCT
ctmj-149	221	32	brain	brain	NOUN
ctmj-149	221	33	barrier	barrier	NOUN
ctmj-149	221	34	.	.	PUNCT
ctmj-149	222	1	published	publish	VERB
ctmj-149	222	2	in	in	ADP
ctmj-149	222	3	2001	2001	NUM
ctmj-149	222	4	in	in	ADP
ctmj-149	222	5	the	the	DET
ctmj-149	222	6	journal	journal	NOUN
ctmj-149	222	7	of	of	ADP
ctmj-149	222	8	pharmaceutical	pharmaceutical	NOUN
ctmj-149	222	9	science	science	NOUN
ctmj-149	222	10	,	,	PUNCT
ctmj-149	222	11	volume	volume	NOUN
ctmj-149	222	12	90	90	NUM
ctmj-149	222	13	,	,	PUNCT
ctmj-149	222	14	pages	page	NOUN
ctmj-149	222	15	1681–1698	1681–1698	NUM
ctmj-149	222	16	.	.	PUNCT
ctmj-149	223	1	the	the	DET
ctmj-149	223	2	correlation	correlation	NOUN
ctmj-149	223	3	between	between	ADP
ctmj-149	223	4	in	in	ADP
ctmj-149	223	5	situ	situ	ADJ
ctmj-149	223	6	brain	brain	NOUN
ctmj-149	223	7	permeability	permeability	NOUN
ctmj-149	223	8	and	and	CCONJ
ctmj-149	223	9	brain	brain	NOUN
ctmj-149	223	10	free	free	ADJ
ctmj-149	223	11	fraction	fraction	NOUN
ctmj-149	223	12	:	:	PUNCT
ctmj-149	223	13	a	a	DET
ctmj-149	223	14	study	study	NOUN
ctmj-149	223	15	by	by	ADP
ctmj-149	223	16	summerfield	summerfield	PROPN
ctmj-149	223	17	sg	sg	PROPN
ctmj-149	223	18	,	,	PUNCT
ctmj-149	223	19	read	read	VERB
ctmj-149	223	20	k	k	PROPN
ctmj-149	223	21	,	,	PUNCT
ctmj-149	223	22	begley	begley	NOUN
ctmj-149	223	23	dj	dj	PROPN
ctmj-149	223	24	,	,	PUNCT
ctmj-149	223	25	and	and	CCONJ
ctmj-149	223	26	colleagues	colleague	NOUN
ctmj-149	223	27	on	on	ADP
ctmj-149	223	28	drug	drug	NOUN
ctmj-149	223	29	disposal	disposal	NOUN
ctmj-149	223	30	in	in	ADP
ctmj-149	223	31	the	the	DET
ctmj-149	223	32	central	central	ADJ
ctmj-149	223	33	nervous	nervous	ADJ
ctmj-149	223	34	system	system	NOUN
ctmj-149	223	35	.	.	PUNCT
ctmj-149	224	1	scientific	scientific	ADJ
ctmj-149	224	2	reports	report	NOUN
ctmj-149	224	3	,	,	PUNCT
ctmj-149	224	4	volume	volume	NOUN
ctmj-149	224	5	322	322	NUM
ctmj-149	224	6	issue	issue	NOUN
ctmj-149	224	7	1	1	NUM
ctmj-149	224	8	,	,	PUNCT
ctmj-149	224	9	pages	page	NOUN
ctmj-149	224	10	205–213	205–213	NUM
ctmj-149	224	11	,	,	PUNCT
ctmj-149	224	12	ctmj	ctmj	NOUN
ctmj-149	224	13	|	|	ADV
ctmj-149	224	14	traditionalmedicinejournals.com	traditionalmedicinejournals.com	X
ctmj-149	224	15	chinese	chinese	ADJ
ctmj-149	224	16	traditional	traditional	ADJ
ctmj-149	224	17	medicine	medicine	NOUN
ctmj-149	224	18	journal	journal	NOUN
ctmj-149	224	19	|	|	ADV
ctmj-149	224	20	2024	2024	NUM
ctmj-149	224	21	|	|	ADV
ctmj-149	224	22	vol	vol	NOUN
ctmj-149	224	23	7	7	NUM
ctmj-149	224	24	|	|	NOUN
ctmj-149	224	25	issue	issue	VERB
ctmj-149	224	26	1	1	NUM
ctmj-149	224	27	issn	issn	X
ctmj-149	224	28	:	:	PUNCT
ctmj-149	224	29	2693	2693	NUM
ctmj-149	224	30	6356	6356	NUM
ctmj-149	224	31	2024	2024	NUM
ctmj-149	224	32	|	|	ADV
ctmj-149	224	33	vol	vol	NOUN
ctmj-149	224	34	1	1	NUM
ctmj-149	225	1	|	|	ADV
ctmj-149	225	2	issue	issue	VERB
ctmj-149	225	3	1	1	NUM
ctmj-149	225	4	2007.reichel	2007.reichel	NUM
ctmj-149	225	5	a.	a.	NOUN
ctmj-149	225	6	:	:	PUNCT
ctmj-149	225	7	the	the	DET
ctmj-149	225	8	ever	ever	ADV
ctmj-149	225	9	-	-	PUNCT
ctmj-149	225	10	changing	change	VERB
ctmj-149	225	11	new	new	ADJ
ctmj-149	225	12	idea	idea	NOUN
ctmj-149	225	13	of	of	ADP
ctmj-149	225	14	cns	cns	NOUN
ctmj-149	225	15	penetration	penetration	NOUN
ctmj-149	225	16	in	in	ADP
ctmj-149	225	17	drug	drug	NOUN
ctmj-149	225	18	discovery	discovery	NOUN
ctmj-149	225	19	:	:	PUNCT
ctmj-149	225	20	the	the	DET
ctmj-149	225	21	fundamentals	fundamental	NOUN
ctmj-149	225	22	and	and	CCONJ
ctmj-149	225	23	consequences	consequence	NOUN
ctmj-149	225	24	.	.	PUNCT
ctmj-149	226	1	published	publish	VERB
ctmj-149	226	2	in	in	ADP
ctmj-149	226	3	2009	2009	NUM
ctmj-149	226	4	in	in	ADP
ctmj-149	226	5	the	the	DET
ctmj-149	226	6	journal	journal	ADJ
ctmj-149	226	7	chem	chem	NOUN
ctmj-149	226	8	biodiversity	biodiversity	NOUN
ctmj-149	226	9	,	,	PUNCT
ctmj-149	226	10	volume	volume	NOUN
ctmj-149	226	11	6	6	NUM
ctmj-149	226	12	,	,	PUNCT
ctmj-149	226	13	pages	page	NOUN
ctmj-149	226	14	2030–2049	2030–2049	NUM
ctmj-149	226	15	.	.	PUNCT
ctmj-149	227	1	by	by	ADP
ctmj-149	227	2	mahar	mahar	PROPN
ctmj-149	227	3	doan	doan	PROPN
ctmj-149	227	4	km	km	PROPN
ctmj-149	227	5	,	,	PUNCT
ctmj-149	227	6	humphreys	humphreys	PROPN
ctmj-149	227	7	je	je	PROPN
ctmj-149	227	8	,	,	PUNCT
ctmj-149	227	9	webster	webster	PROPN
ctmj-149	227	10	lo	lo	PROPN
ctmj-149	227	11	,	,	PUNCT
ctmj-149	227	12	and	and	CCONJ
ctmj-149	227	13	colleagues	colleague	NOUN
ctmj-149	227	14	.	.	PUNCT
ctmj-149	228	1	classification	classification	NOUN
ctmj-149	228	2	of	of	ADP
ctmj-149	228	3	medications	medication	NOUN
ctmj-149	228	4	for	for	ADP
ctmj-149	228	5	the	the	DET
ctmj-149	228	6	central	central	ADJ
ctmj-149	228	7	nervous	nervous	ADJ
ctmj-149	228	8	system	system	NOUN
ctmj-149	228	9	(	(	PUNCT
ctmj-149	228	10	cns	cns	NOUN
ctmj-149	228	11	)	)	PUNCT
ctmj-149	228	12	and	and	CCONJ
ctmj-149	228	13	those	those	PRON
ctmj-149	228	14	for	for	ADP
ctmj-149	228	15	the	the	DET
ctmj-149	228	16	non	non	ADJ
ctmj-149	228	17	-	-	NOUN
ctmj-149	228	18	cns	cns	NOUN
ctmj-149	228	19	is	be	AUX
ctmj-149	228	20	based	base	VERB
ctmj-149	228	21	on	on	ADP
ctmj-149	228	22	passive	passive	ADJ
ctmj-149	228	23	permeability	permeability	NOUN
ctmj-149	228	24	and	and	CCONJ
ctmj-149	228	25	efflux	efflux	AUX
ctmj-149	228	26	mediated	mediate	VERB
ctmj-149	228	27	by	by	ADP
ctmj-149	228	28	pglycoprotein	pglycoprotein	ADJ
ctmj-149	228	29	.	.	PUNCT
ctmj-149	229	1	journal	journal	PROPN
ctmj-149	229	2	of	of	ADP
ctmj-149	229	3	pharmaceutical	pharmaceutical	NOUN
ctmj-149	229	4	and	and	CCONJ
ctmj-149	229	5	clinical	clinical	ADJ
ctmj-149	229	6	therapeutics	therapeutic	NOUN
ctmj-149	229	7	,	,	PUNCT
ctmj-149	229	8	2002	2002	NUM
ctmj-149	229	9	,	,	PUNCT
ctmj-149	229	10	vol	vol	NOUN
ctmj-149	229	11	.	.	PROPN
ctmj-149	229	12	303	303	NUM
ctmj-149	229	13	,	,	PUNCT
ctmj-149	229	14	pages	page	NOUN
ctmj-149	229	15	1029	1029	NUM
ctmj-149	229	16	–	–	PUNCT
ctmj-149	229	17	1037	1037	NUM
ctmj-149	229	18	.	.	PUNCT
ctmj-149	230	1	2.the	2.the	DET
ctmj-149	230	2	inhibition	inhibition	NOUN
ctmj-149	230	3	and	and	CCONJ
ctmj-149	230	4	induction	induction	NOUN
ctmj-149	230	5	of	of	ADP
ctmj-149	230	6	pglycoprotein	pglycoprotein	ADJ
ctmj-149	230	7	mediates	mediate	NOUN
ctmj-149	230	8	drug	drug	NOUN
ctmj-149	230	9	-	-	PUNCT
ctmj-149	230	10	drug	drug	NOUN
ctmj-149	230	11	interactions	interaction	NOUN
ctmj-149	230	12	(	(	PUNCT
ctmj-149	230	13	lin	lin	PROPN
ctmj-149	230	14	jh	jh	PROPN
ctmj-149	230	15	)	)	PUNCT
ctmj-149	230	16	.	.	PUNCT
ctmj-149	231	1	current	current	ADJ
ctmj-149	231	2	drug	drug	NOUN
ctmj-149	231	3	delivery	delivery	NOUN
ctmj-149	231	4	reviews	review	NOUN
ctmj-149	231	5	.	.	PUNCT
ctmj-149	232	1	2003;55:53	2003;55:53	NUM
ctmj-149	232	2	–	–	PUNCT
ctmj-149	232	3	81	81	NUM
ctmj-149	232	4	.	.	PUNCT
ctmj-149	233	1	30.authors	30.authors	NUM
ctmj-149	233	2	:	:	PUNCT
ctmj-149	233	3	hellinger	hellinger	PROPN
ctmj-149	233	4	e	e	PROPN
ctmj-149	233	5	,	,	PUNCT
ctmj-149	233	6	veszelka	veszelka	NOUN
ctmj-149	233	7	s	s	PROPN
ctmj-149	233	8	,	,	PUNCT
ctmj-149	233	9	to'th	to'th	PROPN
ctmj-149	233	10	ae	ae	PROPN
ctmj-149	233	11	,	,	PUNCT
ctmj-149	233	12	and	and	CCONJ
ctmj-149	233	13	others	other	NOUN
ctmj-149	233	14	.	.	PUNCT
ctmj-149	234	1	brain	brain	NOUN
ctmj-149	234	2	capillary	capillary	ADJ
ctmj-149	234	3	endothelial	endothelial	ADJ
ctmj-149	234	4	cell	cell	NOUN
ctmj-149	234	5	-	-	PUNCT
ctmj-149	234	6	based	base	VERB
ctmj-149	234	7	and	and	CCONJ
ctmj-149	234	8	epithelial	epithelial	ADJ
ctmj-149	234	9	cell	cell	NOUN
ctmj-149	234	10	-	-	PUNCT
ctmj-149	234	11	based	base	VERB
ctmj-149	234	12	surrogate	surrogate	ADJ
ctmj-149	234	13	blood	blood	NOUN
ctmj-149	234	14	-	-	PUNCT
ctmj-149	234	15	brain	brain	NOUN
ctmj-149	234	16	barrier	barrier	NOUN
ctmj-149	234	17	penetration	penetration	NOUN
ctmj-149	234	18	models	model	NOUN
ctmj-149	234	19	compared	compare	VERB
ctmj-149	234	20	(	(	PUNCT
ctmj-149	234	21	mdckmdr1	mdckmdr1	NOUN
ctmj-149	234	22	,	,	PUNCT
ctmj-149	234	23	caco-2	caco-2	NUM
ctmj-149	234	24	,	,	PUNCT
ctmj-149	234	25	and	and	CCONJ
ctmj-149	234	26	vb	vb	NOUN
ctmj-149	234	27	-	-	PUNCT
ctmj-149	234	28	caco-2	caco-2	NUM
ctmj-149	234	29	)	)	PUNCT
ctmj-149	234	30	.	.	PUNCT
ctmj-149	235	1	euro	euro	PROPN
ctmj-149	235	2	journal	journal	PROPN
ctmj-149	235	3	of	of	ADP
ctmj-149	235	4	pharmaceutical	pharmaceutical	NOUN
ctmj-149	235	5	and	and	CCONJ
ctmj-149	235	6	biopharmaceutical	biopharmaceutical	NOUN
ctmj-149	235	7	sciences	science	NOUN
ctmj-149	235	8	,	,	PUNCT
ctmj-149	235	9	2012	2012	NUM
ctmj-149	235	10	,	,	PUNCT
ctmj-149	235	11	82	82	NUM
ctmj-149	235	12	,	,	PUNCT
ctmj-149	235	13	340–351	340–351	NUM
ctmj-149	235	14	.	.	PUNCT
ctmj-149	236	1	31.absorption	31.absorption	NUM
ctmj-149	236	2	,	,	PUNCT
ctmj-149	236	3	distribution	distribution	NOUN
ctmj-149	236	4	,	,	PUNCT
ctmj-149	236	5	and	and	CCONJ
ctmj-149	236	6	excretion	excretion	NOUN
ctmj-149	236	7	of	of	ADP
ctmj-149	236	8	drugs	drug	NOUN
ctmj-149	236	9	:	:	PUNCT
ctmj-149	236	10	the	the	DET
ctmj-149	236	11	role	role	NOUN
ctmj-149	236	12	of	of	ADP
ctmj-149	236	13	transport	transport	NOUN
ctmj-149	236	14	proteins	protein	NOUN
ctmj-149	236	15	(	(	PUNCT
ctmj-149	236	16	ayrton	ayrton	PROPN
ctmj-149	236	17	&	&	CCONJ
ctmj-149	236	18	morgan	morgan	PROPN
ctmj-149	236	19	,	,	PUNCT
ctmj-149	236	20	2006	2006	NUM
ctmj-149	236	21	)	)	PUNCT
ctmj-149	236	22	.	.	PUNCT
ctmj-149	237	1	citation	citation	NOUN
ctmj-149	237	2	:	:	PUNCT
ctmj-149	238	1	xenobiotica	xenobiotica	PROPN
ctmj-149	238	2	,	,	PUNCT
ctmj-149	238	3	2001	2001	NUM
ctmj-149	238	4	,	,	PUNCT
ctmj-149	238	5	31	31	NUM
ctmj-149	238	6	:	:	PUNCT
ctmj-149	238	7	469–497	469–497	NUM
ctmj-149	238	8	.	.	PUNCT
ctmj-149	239	1	32.in	32.in	NUM
ctmj-149	239	2	the	the	DET
ctmj-149	239	3	bloodbrain	bloodbrain	NOUN
ctmj-149	239	4	barrier	barrier	NOUN
ctmj-149	239	5	,	,	PUNCT
ctmj-149	239	6	abc	abc	PROPN
ctmj-149	239	7	transporters	transporter	NOUN
ctmj-149	239	8	are	be	AUX
ctmj-149	239	9	involved	involve	VERB
ctmj-149	239	10	(	(	PUNCT
ctmj-149	239	11	miller	miller	PROPN
ctmj-149	239	12	ds	ds	PROPN
ctmj-149	239	13	)	)	PUNCT
ctmj-149	239	14	.	.	PUNCT
ctmj-149	240	1	“	"	PUNCT
ctmj-149	240	2	curr	curr	VERB
ctmj-149	240	3	top	top	ADJ
ctmj-149	240	4	med	med	PROPN
ctmj-149	240	5	chem	chem	NOUN
ctmj-149	240	6	”	"	PUNCT
ctmj-149	240	7	published	publish	VERB
ctmj-149	240	8	a	a	DET
ctmj-149	240	9	study	study	NOUN
ctmj-149	240	10	in	in	ADP
ctmj-149	240	11	2013	2013	NUM
ctmj-149	240	12	that	that	PRON
ctmj-149	240	13	spanned	span	VERB
ctmj-149	240	14	pages	page	NOUN
ctmj-149	240	15	1295	1295	NUM
ctmj-149	240	16	to	to	ADP
ctmj-149	240	17	1312.models	1312.models	NUM
ctmj-149	240	18	of	of	ADP
ctmj-149	240	19	blood	blood	NOUN
ctmj-149	240	20	-	-	PUNCT
ctmj-149	240	21	brain	brain	NOUN
ctmj-149	240	22	barrier	barrier	NOUN
ctmj-149	240	23	penetration	penetration	NOUN
ctmj-149	240	24	based	base	VERB
ctmj-149	240	25	on	on	ADP
ctmj-149	240	26	cells	cell	NOUN
ctmj-149	240	27	.	.	PUNCT
ctmj-149	241	1	vastag	vastag	PROPN
ctmj-149	241	2	m	m	PROPN
ctmj-149	241	3	,	,	PUNCT
ctmj-149	241	4	hellinger	hellinger	NOUN
ctmj-149	241	5	e	e	NOUN
ctmj-149	241	6	,	,	PUNCT
ctmj-149	241	7	bakk	bakk	ADV
ctmj-149	241	8	ml	ml	PROPN
ctmj-149	241	9	,	,	PUNCT
ctmj-149	241	10	tihanyi	tihanyi	PROPN
ctmj-149	241	11	k.	k.	PROPN
ctmj-149	241	12	—	—	PUNCT
ctmj-149	241	13	schulzke	schulzke	PROPN
ctmj-149	241	14	jd	jd	PROPN
ctmj-149	241	15	,	,	PUNCT
ctmj-149	241	16	ploeger	ploeger	NOUN
ctmj-149	241	17	s	s	PART
ctmj-149	241	18	,	,	PUNCT
ctmj-149	241	19	amasheh	amasheh	PROPN
ctmj-149	241	20	m	m	PROPN
ctmj-149	241	21	,	,	PUNCT
ctmj-149	241	22	et	et	PROPN
ctmj-149	241	23	al	al	PROPN
ctmj-149	241	24	.	.	PUNCT
ctmj-149	242	1	ther	ther	PROPN
ctmj-149	242	2	delivery	delivery	NOUN
ctmj-149	242	3	.	.	PUNCT
ctmj-149	243	1	2011;2:549–553	2011;2:549–553	X
ctmj-149	243	2	.	.	PUNCT
ctmj-149	243	3	ligands	ligand	NOUN
ctmj-149	243	4	between	between	ADP
ctmj-149	243	5	epithelial	epithelial	ADJ
ctmj-149	243	6	cells	cell	NOUN
ctmj-149	243	7	during	during	ADP
ctmj-149	243	8	inflammation	inflammation	NOUN
ctmj-149	243	9	of	of	ADP
ctmj-149	243	10	the	the	DET
ctmj-149	243	11	intestines	intestine	NOUN
ctmj-149	243	12	.	.	PUNCT
ctmj-149	244	1	a	a	DET
ctmj-149	244	2	claudin	claudin	VERB
ctmj-149	244	3	-	-	PUNCT
ctmj-149	244	4	based	base	VERB
ctmj-149	244	5	barrier	barrier	NOUN
ctmj-149	244	6	in	in	ADP
ctmj-149	244	7	both	both	CCONJ
ctmj-149	244	8	simple	simple	ADJ
ctmj-149	244	9	and	and	CCONJ
ctmj-149	244	10	stratified	stratified	ADJ
ctmj-149	244	11	cellular	cellular	ADJ
ctmj-149	244	12	sheets	sheet	NOUN
ctmj-149	244	13	(	(	PUNCT
ctmj-149	244	14	tsukita	tsukita	PROPN
ctmj-149	244	15	s.	s.	PROPN
ctmj-149	244	16	,	,	PUNCT
ctmj-149	244	17	furuse	furuse	NOUN
ctmj-149	244	18	m.	m.	NOUN
ctmj-149	244	19	,	,	PUNCT
ctmj-149	244	20	ann	ann	PROPN
ctmj-149	244	21	.	.	PROPN
ctmj-149	244	22	ny	ny	PROPN
ctmj-149	244	23	acad	acad	PROPN
ctmj-149	244	24	.	.	PUNCT
ctmj-149	245	1	sci	sci	PROPN
ctmj-149	245	2	.	.	PROPN
ctmj-149	245	3	2009	2009	NUM
ctmj-149	245	4	;	;	PUNCT
ctmj-149	245	5	1165	1165	NUM
ctmj-149	245	6	:	:	PUNCT
ctmj-149	245	7	294–300	294–300	NUM
ctmj-149	245	8	)	)	PUNCT
ctmj-149	245	9	.	.	PUNCT
ctmj-149	246	1	this	this	DET
ctmj-149	246	2	article	article	NOUN
ctmj-149	246	3	was	be	AUX
ctmj-149	246	4	written	write	VERB
ctmj-149	246	5	by	by	ADP
ctmj-149	246	6	zahraoui	zahraoui	PROPN
ctmj-149	246	7	a	a	PRON
ctmj-149	246	8	,	,	PUNCT
ctmj-149	246	9	louvard	louvard	ADJ
ctmj-149	246	10	d	d	NOUN
ctmj-149	246	11	,	,	PUNCT
ctmj-149	246	12	and	and	CCONJ
ctmj-149	246	13	galli	galli	NOUN
ctmj-149	246	14	t	t	NOUN
ctmj-149	246	15	and	and	CCONJ
ctmj-149	246	16	was	be	AUX
ctmj-149	246	17	published	publish	VERB
ctmj-149	246	18	in	in	ADP
ctmj-149	246	19	the	the	DET
ctmj-149	246	20	journal	journal	NOUN
ctmj-149	246	21	curr	curr	PROPN
ctmj-149	246	22	opin	opin	NOUN
ctmj-149	246	23	cell	cell	NOUN
ctmj-149	246	24	biol	biol	NOUN
ctmj-149	246	25	in	in	ADP
ctmj-149	246	26	2002	2002	NUM
ctmj-149	246	27	.	.	PUNCT
ctmj-149	247	1	37	37	NUM
ctmj-149	247	2	.	.	PUNCT
ctmj-149	248	1	a	a	DET
ctmj-149	248	2	protein	protein	NOUN
ctmj-149	248	3	complex	complex	ADJ
ctmj-149	248	4	trafficking	trafficking	NOUN
ctmj-149	248	5	and	and	CCONJ
ctmj-149	248	6	signalling	signal	VERB
ctmj-149	248	7	platform	platform	NOUN
ctmj-149	248	8	is	be	AUX
ctmj-149	248	9	the	the	DET
ctmj-149	248	10	tight	tight	ADJ
ctmj-149	248	11	junction	junction	NOUN
ctmj-149	248	12	.	.	PUNCT
ctmj-149	249	1	journal	journal	NOUN
ctmj-149	249	2	of	of	ADP
ctmj-149	249	3	cell	cell	NOUN
ctmj-149	249	4	biology	biology	NOUN
ctmj-149	249	5	.	.	PUNCT
ctmj-149	250	1	2000	2000	NUM
ctmj-149	250	2	;	;	PUNCT
ctmj-149	250	3	151	151	NUM
ctmj-149	250	4	:	:	SYM
ctmj-149	250	5	31	31	NUM
ctmj-149	250	6	–	–	PUNCT
ctmj-149	250	7	36	36	NUM
ctmj-149	250	8	.	.	X
ctmj-149	251	1	37	37	NUM
ctmj-149	251	2	.	.	PUNCT
ctmj-149	252	1	furuse	furuse	PROPN
ctmj-149	252	2	m	m	PROPN
ctmj-149	252	3	,	,	PUNCT
ctmj-149	252	4	hirase	hirase	PROPN
ctmj-149	252	5	t	t	PROPN
ctmj-149	252	6	,	,	PUNCT
ctmj-149	252	7	itoh	itoh	PROPN
ctmj-149	252	8	m	m	PROPN
ctmj-149	252	9	,	,	PUNCT
ctmj-149	252	10	et	et	PROPN
ctmj-149	252	11	al	al	PROPN
ctmj-149	252	12	.	.	PUNCT
ctmj-149	253	1	a	a	DET
ctmj-149	253	2	new	new	ADJ
ctmj-149	253	3	integral	integral	ADJ
ctmj-149	253	4	membrane	membrane	NOUN
ctmj-149	253	5	protein	protein	NOUN
ctmj-149	253	6	called	call	VERB
ctmj-149	253	7	occludin	occludin	NOUN
ctmj-149	253	8	is	be	AUX
ctmj-149	253	9	found	find	VERB
ctmj-149	253	10	in	in	ADP
ctmj-149	253	11	tight	tight	ADJ
ctmj-149	253	12	junctions	junction	NOUN
ctmj-149	253	13	.	.	PUNCT
ctmj-149	254	1	tsukamoto	tsukamoto	PROPN
ctmj-149	254	2	t	t	PROPN
ctmj-149	254	3	,	,	PUNCT
ctmj-149	254	4	nigam	nigam	PROPN
ctmj-149	254	5	sk	sk	PROPN
ctmj-149	254	6	.	.	PUNCT
ctmj-149	255	1	"	"	PUNCT
ctmj-149	255	2	curr	curr	PROPN
ctmj-149	255	3	opin	opin	NOUN
ctmj-149	255	4	cell	cell	NOUN
ctmj-149	255	5	biol	biol	NOUN
ctmj-149	255	6	.	.	PUNCT
ctmj-149	255	7	"	"	PUNCT
ctmj-149	256	1	1993;123:1777–1788	1993;123:1777–1788	NUM
ctmj-149	256	2	.	.	PUNCT
ctmj-149	257	1	function	function	NOUN
ctmj-149	257	2	of	of	ADP
ctmj-149	257	3	phosphorylated	phosphorylate	VERB
ctmj-149	257	4	tyrosines	tyrosine	NOUN
ctmj-149	257	5	in	in	ADP
ctmj-149	257	6	occludin	occludin	NOUN
ctmj-149	257	7	and	and	CCONJ
ctmj-149	257	8	other	other	ADJ
ctmj-149	257	9	tight	tight	ADJ
ctmj-149	257	10	junction	junction	NOUN
ctmj-149	257	11	protein	protein	NOUN
ctmj-149	257	12	reassembly	reassembly	ADV
ctmj-149	257	13	.	.	PUNCT
ctmj-149	258	1	i	i	PRON
ctmj-149	258	2	am	be	AUX
ctmj-149	258	3	journal	journal	NOUN
ctmj-149	258	4	of	of	ADP
ctmj-149	258	5	physiology	physiology	NOUN
ctmj-149	258	6	//	//	NOUN
ctmj-149	258	7	cell	cell	NOUN
ctmj-149	258	8	chapter	chapter	NOUN
ctmj-149	258	9	39	39	NUM
ctmj-149	258	10	:	:	PUNCT
ctmj-149	258	11	chen	chen	PROPN
ctmj-149	258	12	yh	yh	PROPN
ctmj-149	258	13	,	,	PUNCT
ctmj-149	258	14	lu	lu	PROPN
ctmj-149	258	15	q	q	NOUN
ctmj-149	258	16	,	,	PUNCT
ctmj-149	258	17	goodenough	goodenough	PROPN
ctmj-149	258	18	da	da	PROPN
ctmj-149	258	19	,	,	PUNCT
ctmj-149	258	20	jeansonne	jeansonne	PROPN
ctmj-149	258	21	b.	b.	PROPN
ctmj-149	258	22	appeared	appear	VERB
ctmj-149	258	23	in	in	ADP
ctmj-149	258	24	physiology	physiology	NOUN
ctmj-149	258	25	(	(	PUNCT
ctmj-149	258	26	1999	1999	NUM
ctmj-149	258	27	,	,	PUNCT
ctmj-149	258	28	276:737–750	276:737–750	NUM
ctmj-149	258	29	)	)	PUNCT
ctmj-149	258	30	.	.	PUNCT
ctmj-149	259	1	during	during	ADP
ctmj-149	259	2	the	the	DET
ctmj-149	259	3	development	development	NOUN
ctmj-149	259	4	of	of	ADP
ctmj-149	259	5	tight	tight	ADJ
ctmj-149	259	6	junctions	junction	NOUN
ctmj-149	259	7	in	in	ADP
ctmj-149	259	8	canine	canine	NOUN
ctmj-149	259	9	kidney	kidney	NOUN
ctmj-149	259	10	epithelial	epithelial	ADJ
ctmj-149	259	11	cells	cell	NOUN
ctmj-149	259	12	,	,	PUNCT
ctmj-149	259	13	the	the	DET
ctmj-149	259	14	nonreceptor	nonreceptor	ADJ
ctmj-149	259	15	tyrosine	tyrosine	PROPN
ctmj-149	259	16	kinase	kinase	PROPN
ctmj-149	259	17	cyes	cyes	PROPN
ctmj-149	259	18	interacts	interact	VERB
ctmj-149	259	19	with	with	ADP
ctmj-149	259	20	occludin	occludin	PROPN
ctmj-149	259	21	.	.	PUNCT
ctmj-149	260	1	report	report	NOUN
ctmj-149	260	2	from	from	ADP
ctmj-149	260	3	furuse	furuse	PROPN
ctmj-149	260	4	et	et	PROPN
ctmj-149	260	5	al	al	PROPN
ctmj-149	260	6	.	.	PROPN
ctmj-149	260	7	in	in	ADP
ctmj-149	260	8	mol	mol	PROPN
ctmj-149	260	9	.	.	PUNCT
ctmj-149	261	1	biol	biol	PROPN
ctmj-149	261	2	.	.	PUNCT
ctmj-149	262	1	cell	cell	NOUN
ctmj-149	262	2	.	.	PUNCT
ctmj-149	263	1	2002;13:1227–1237	2002;13:1227–1237	NUM
ctmj-149	263	2	.	.	PUNCT
ctmj-149	264	1	40	40	NUM
ctmj-149	264	2	.	.	PUNCT
ctmj-149	265	1	two	two	NUM
ctmj-149	265	2	new	new	ADJ
ctmj-149	265	3	integral	integral	ADJ
ctmj-149	265	4	membrane	membrane	NOUN
ctmj-149	265	5	proteins	protein	NOUN
ctmj-149	265	6	,	,	PUNCT
ctmj-149	265	7	claudin-1	claudin-1	NUM
ctmj-149	265	8	and	and	CCONJ
ctmj-149	265	9	-2	-2	INTJ
ctmj-149	265	10	,	,	PUNCT
ctmj-149	265	11	that	that	PRON
ctmj-149	265	12	have	have	VERB
ctmj-149	265	13	no	no	DET
ctmj-149	265	14	sequence	sequence	NOUN
ctmj-149	265	15	resemblance	resemblance	NOUN
ctmj-149	265	16	to	to	ADP
ctmj-149	265	17	occludin	occludin	NOUN
ctmj-149	265	18	yet	yet	ADV
ctmj-149	265	19	localise	localise	VERB
ctmj-149	265	20	to	to	ADP
ctmj-149	265	21	tight	tight	ADJ
ctmj-149	265	22	junctions	junction	NOUN
ctmj-149	265	23	.	.	PUNCT
ctmj-149	266	1	published	publish	VERB
ctmj-149	266	2	in	in	ADP
ctmj-149	266	3	the	the	DET
ctmj-149	266	4	journal	journal	NOUN
ctmj-149	266	5	of	of	ADP
ctmj-149	266	6	cell	cell	NOUN
ctmj-149	266	7	biology	biology	NOUN
ctmj-149	266	8	in	in	ADP
ctmj-149	266	9	1998	1998	NUM
ctmj-149	266	10	,	,	PUNCT
ctmj-149	266	11	volume	volume	NOUN
ctmj-149	266	12	141	141	NUM
ctmj-149	266	13	,	,	PUNCT
ctmj-149	266	14	pages	page	NOUN
ctmj-149	266	15	1539	1539	NUM
ctmj-149	266	16	–	–	PUNCT
ctmj-149	266	17	1550	1550	NUM
ctmj-149	266	18	,	,	PUNCT
ctmj-149	266	19	the	the	DET
ctmj-149	266	20	work	work	NOUN
ctmj-149	266	21	of	of	ADP
ctmj-149	266	22	furuse	furuse	NOUN
ctmj-149	266	23	,	,	PUNCT
ctmj-149	266	24	sasaki	sasaki	PROPN
ctmj-149	266	25	,	,	PUNCT
ctmj-149	266	26	fujimoto	fujimoto	PROPN
ctmj-149	266	27	,	,	PUNCT
ctmj-149	266	28	and	and	CCONJ
ctmj-149	266	29	tsukita	tsukita	VERB
ctmj-149	266	30	delves	delf	NOUN
ctmj-149	266	31	into	into	ADP
ctmj-149	266	32	this	this	DET
ctmj-149	266	33	topic	topic	NOUN
ctmj-149	266	34	.	.	PUNCT
ctmj-149	267	1	claudin-1	claudin-1	NUM
ctmj-149	267	2	or	or	CCONJ
ctmj-149	267	3	-2	-2	INTJ
ctmj-149	267	4	,	,	PUNCT
ctmj-149	267	5	a	a	DET
ctmj-149	267	6	single	single	ADJ
ctmj-149	267	7	gene	gene	NOUN
ctmj-149	267	8	product	product	NOUN
ctmj-149	267	9	,	,	PUNCT
ctmj-149	267	10	attracts	attract	VERB
ctmj-149	267	11	occludin	occludin	NOUN
ctmj-149	267	12	to	to	ADP
ctmj-149	267	13	fibroblasts	fibroblast	NOUN
ctmj-149	267	14	and	and	CCONJ
ctmj-149	267	15	restores	restore	VERB
ctmj-149	267	16	the	the	DET
ctmj-149	267	17	integrity	integrity	NOUN
ctmj-149	267	18	of	of	ADP
ctmj-149	267	19	tight	tight	ADJ
ctmj-149	267	20	junction	junction	NOUN
ctmj-149	267	21	strands	strand	NOUN
ctmj-149	267	22	.	.	PUNCT
ctmj-149	268	1	published	publish	VERB
ctmj-149	268	2	in	in	ADP
ctmj-149	268	3	the	the	DET
ctmj-149	268	4	journal	journal	NOUN
ctmj-149	268	5	of	of	ADP
ctmj-149	268	6	cell	cell	NOUN
ctmj-149	268	7	biology	biology	NOUN
ctmj-149	268	8	in	in	ADP
ctmj-149	268	9	1998	1998	NUM
ctmj-149	268	10	,	,	PUNCT
ctmj-149	268	11	volume	volume	NOUN
ctmj-149	268	12	143	143	NUM
ctmj-149	268	13	,	,	PUNCT
ctmj-149	268	14	pages	page	NOUN
ctmj-149	268	15	391	391	NUM
ctmj-149	268	16	into	into	ADP
ctmj-149	268	17	401	401	NUM
ctmj-149	268	18	.	.	PUNCT
ctmj-149	269	1	the	the	DET
ctmj-149	269	2	authors	author	NOUN
ctmj-149	269	3	of	of	ADP
ctmj-149	269	4	the	the	DET
ctmj-149	269	5	42nd	42nd	ADJ
ctmj-149	269	6	article	article	NOUN
ctmj-149	269	7	include	include	VERB
ctmj-149	269	8	kubota	kubota	PROPN
ctmj-149	269	9	,	,	PUNCT
ctmj-149	269	10	furuse	furuse	NOUN
ctmj-149	269	11	,	,	PUNCT
ctmj-149	269	12	sasaki	sasaki	NOUN
ctmj-149	269	13	,	,	PUNCT
ctmj-149	269	14	and	and	CCONJ
ctmj-149	269	15	others	other	NOUN
ctmj-149	269	16	.	.	PUNCT
ctmj-149	270	1	claudins	claudin	NOUN
ctmj-149	270	2	are	be	AUX
ctmj-149	270	3	a	a	DET
ctmj-149	270	4	class	class	NOUN
ctmj-149	270	5	of	of	ADP
ctmj-149	270	6	integral	integral	ADJ
ctmj-149	270	7	membrane	membrane	NOUN
ctmj-149	270	8	proteins	protein	NOUN
ctmj-149	270	9	found	find	VERB
ctmj-149	270	10	at	at	ADP
ctmj-149	270	11	tight	tight	ADJ
ctmj-149	270	12	junctions	junction	NOUN
ctmj-149	270	13	that	that	PRON
ctmj-149	270	14	have	have	VERB
ctmj-149	270	15	cell	cell	NOUN
ctmj-149	270	16	-	-	PUNCT
ctmj-149	270	17	adhesion	adhesion	NOUN
ctmj-149	270	18	action	action	NOUN
ctmj-149	270	19	that	that	PRON
ctmj-149	270	20	is	be	AUX
ctmj-149	270	21	not	not	PART
ctmj-149	270	22	reliant	reliant	ADJ
ctmj-149	270	23	on	on	ADP
ctmj-149	270	24	ca2	ca2	PROPN
ctmj-149	270	25	+	+	PROPN
ctmj-149	270	26	.	.	PROPN
ctmj-149	271	1	published	publish	VERB
ctmj-149	271	2	in	in	ADP
ctmj-149	271	3	the	the	DET
ctmj-149	271	4	journal	journal	NOUN
ctmj-149	271	5	current	current	ADJ
ctmj-149	271	6	biology	biology	NOUN
ctmj-149	271	7	,	,	PUNCT
ctmj-149	271	8	volume	volume	NOUN
ctmj-149	271	9	9	9	NUM
ctmj-149	271	10	,	,	PUNCT
ctmj-149	271	11	pages	page	NOUN
ctmj-149	271	12	1035–1038	1035–1038	NUM
ctmj-149	271	13	,	,	PUNCT
ctmj-149	271	14	1999	1999	NUM
ctmj-149	271	15	.	.	PUNCT
ctmj-149	272	1	andrade	andrade	PROPN
ctmj-149	272	2	ke	ke	PROPN
ctmj-149	272	3	,	,	PUNCT
ctmj-149	272	4	witt	witt	PROPN
ctmj-149	272	5	ka	ka	PROPN
ctmj-149	272	6	,	,	PUNCT
ctmj-149	272	7	43	43	NUM
ctmj-149	272	8	.	.	PUNCT
ctmj-149	273	1	ischemic	ischemic	ADJ
ctmj-149	273	2	stroke	stroke	NOUN
ctmj-149	273	3	,	,	PUNCT
ctmj-149	273	4	bloodbrain	bloodbrain	NOUN
ctmj-149	273	5	barrier	barrier	NOUN
ctmj-149	273	6	permeability	permeability	NOUN
ctmj-149	273	7	,	,	PUNCT
ctmj-149	273	8	and	and	CCONJ
ctmj-149	273	9	the	the	DET
ctmj-149	273	10	tight	tight	ADJ
ctmj-149	273	11	junction	junction	NOUN
ctmj-149	273	12	.	.	PUNCT
ctmj-149	274	1	the	the	DET
ctmj-149	274	2	neurobiology	neurobiology	NOUN
ctmj-149	274	3	of	of	ADP
ctmj-149	274	4	diseases	disease	NOUN
ctmj-149	274	5	.	.	PUNCT
ctmj-149	274	6	2008	2008	NUM
ctmj-149	274	7	;	;	PUNCT
ctmj-149	274	8	32	32	NUM
ctmj-149	274	9	:	:	SYM
ctmj-149	274	10	200	200	NUM
ctmj-149	274	11	 	 	SPACE
ctmj-149	274	12	219	219	NUM
ctmj-149	274	13	.	.	PUNCT
ctmj-149	274	14	chapter	chapter	NOUN
ctmj-149	274	15	44	44	NUM
ctmj-149	274	16	:	:	PUNCT
ctmj-149	274	17	shen	shen	PROPN
ctmj-149	274	18	l.	l.	PROPN
ctmj-149	274	19	,	,	PUNCT
ctmj-149	274	20	weber	weber	PROPN
ctmj-149	274	21	cr	cr	PROPN
ctmj-149	274	22	.	.	PROPN
ctmj-149	274	23	,	,	PUNCT
ctmj-149	274	24	raleigh	raleigh	PROPN
ctmj-149	274	25	dr	dr	PROPN
ctmj-149	274	26	.	.	PROPN
ctmj-149	274	27	,	,	PUNCT
ctmj-149	274	28	yu	yu	PROPN
ctmj-149	274	29	d.	d.	PROPN
ctmj-149	274	30	,	,	PUNCT
ctmj-149	274	31	and	and	CCONJ
ctmj-149	274	32	tumer	tumer	PROPN
ctmj-149	274	33	jr	jr	PROPN
ctmj-149	274	34	.	.	PROPN
ctmj-149	274	35	leak	leak	NOUN
ctmj-149	274	36	paths	path	NOUN
ctmj-149	274	37	and	and	CCONJ
ctmj-149	274	38	tight	tight	ADJ
ctmj-149	274	39	junction	junction	NOUN
ctmj-149	274	40	pores	pore	NOUN
ctmj-149	274	41	:	:	PUNCT
ctmj-149	274	42	a	a	DET
ctmj-149	274	43	dynamic	dynamic	ADJ
ctmj-149	274	44	pair	pair	NOUN
ctmj-149	274	45	.	.	PUNCT
ctmj-149	275	1	published	publish	VERB
ctmj-149	275	2	in	in	ADP
ctmj-149	275	3	the	the	DET
ctmj-149	275	4	annual	annual	ADJ
ctmj-149	275	5	review	review	NOUN
ctmj-149	275	6	of	of	ADP
ctmj-149	275	7	physiology	physiology	NOUN
ctmj-149	275	8	,	,	PUNCT
ctmj-149	275	9	2011;73:283	2011;73:283	NUM
ctmj-149	275	10	–	–	PUNCT
ctmj-149	275	11	e309	e309	PROPN
ctmj-149	275	12	.	.	PUNCT
ctmj-149	276	1	rho	rho	ADJ
ctmj-149	276	2	gtpases	gtpase	NOUN
ctmj-149	276	3	and	and	CCONJ
ctmj-149	276	4	the	the	DET
ctmj-149	276	5	actin	actin	NOUN
ctmj-149	276	6	cytoskeleton	cytoskeleton	PROPN
ctmj-149	276	7	were	be	AUX
ctmj-149	276	8	discussed	discuss	VERB
ctmj-149	276	9	by	by	ADP
ctmj-149	276	10	hall	hall	NOUN
ctmj-149	276	11	in	in	ADP
ctmj-149	276	12	his	his	PRON
ctmj-149	276	13	1998	1998	NUM
ctmj-149	276	14	science	science	NOUN
ctmj-149	276	15	article	article	NOUN
ctmj-149	276	16	(	(	PUNCT
ctmj-149	276	17	279:112	279:112	PROPN
ctmj-149	276	18	)	)	PUNCT
ctmj-149	276	19	.	.	PUNCT
ctmj-149	277	1	42	42	NUM
ctmj-149	277	2	.	.	PUNCT
ctmj-149	278	1	ridley	ridley	PROPN
ctmj-149	278	2	aj	aj	PROPN
ctmj-149	278	3	,	,	PUNCT
ctmj-149	278	4	burridge	burridge	PROPN
ctmj-149	278	5	k	k	PROPN
ctmj-149	278	6	,	,	PUNCT
ctmj-149	278	7	schwartz	schwartz	PROPN
ctmj-149	278	8	ma	ma	PROPN
ctmj-149	278	9	,	,	PUNCT
ctmj-149	278	10	et	et	PROPN
ctmj-149	278	11	al	al	PROPN
ctmj-149	278	12	.	.	PROPN
ctmj-149	279	1	through	through	ADP
ctmj-149	279	2	cell	cell	NOUN
ctmj-149	279	3	migration	migration	NOUN
ctmj-149	279	4	,	,	PUNCT
ctmj-149	279	5	signals	signal	NOUN
ctmj-149	279	6	are	be	AUX
ctmj-149	279	7	integrated	integrate	VERB
ctmj-149	279	8	from	from	ADP
ctmj-149	279	9	the	the	DET
ctmj-149	279	10	front	front	NOUN
ctmj-149	279	11	to	to	ADP
ctmj-149	279	12	the	the	DET
ctmj-149	279	13	rear	rear	NOUN
ctmj-149	279	14	.	.	PUNCT
ctmj-149	280	1	the	the	DET
ctmj-149	280	2	publication	publication	NOUN
ctmj-149	280	3	is	be	AUX
ctmj-149	280	4	titled	title	VERB
ctmj-149	280	5	"	"	PUNCT
ctmj-149	280	6	science	science	NOUN
ctmj-149	280	7	"	"	PUNCT
ctmj-149	280	8	and	and	CCONJ
ctmj-149	280	9	was	be	AUX
ctmj-149	280	10	published	publish	VERB
ctmj-149	280	11	in	in	ADP
ctmj-149	280	12	2003	2003	NUM
ctmj-149	280	13	with	with	ADP
ctmj-149	280	14	the	the	DET
ctmj-149	280	15	doi	doi	NOUN
ctmj-149	280	16	3031709	3031709	NUM
ctmj-149	280	17	.	.	PUNCT
ctmj-149	281	1	47	47	NUM
ctmj-149	281	2	.	.	PUNCT
ctmj-149	282	1	ivanov	ivanov	PROPN
ctmj-149	282	2	ai	ai	VERB
ctmj-149	282	3	.	.	PUNCT
ctmj-149	282	4	actin	actin	NOUN
ctmj-149	282	5	proteins	protein	NOUN
ctmj-149	282	6	that	that	PRON
ctmj-149	282	7	regulate	regulate	VERB
ctmj-149	282	8	the	the	DET
ctmj-149	282	9	building	building	NOUN
ctmj-149	282	10	and	and	CCONJ
ctmj-149	282	11	breakdown	breakdown	NOUN
ctmj-149	282	12	of	of	ADP
ctmj-149	282	13	apical	apical	ADJ
ctmj-149	282	14	junctions	junction	NOUN
ctmj-149	282	15	in	in	ADP
ctmj-149	282	16	epithelial	epithelial	ADJ
ctmj-149	282	17	cells	cell	NOUN
ctmj-149	282	18	.	.	PUNCT
ctmj-149	283	1	in	in	ADP
ctmj-149	283	2	2008	2008	NUM
ctmj-149	283	3	,	,	PUNCT
ctmj-149	283	4	the	the	DET
ctmj-149	283	5	article	article	NOUN
ctmj-149	283	6	was	be	AUX
ctmj-149	283	7	published	publish	VERB
ctmj-149	283	8	in	in	ADP
ctmj-149	283	9	front	front	ADJ
ctmj-149	283	10	bio	bio	PROPN
ctmj-149	283	11	sci	sci	PROPN
ctmj-149	283	12	with	with	ADP
ctmj-149	283	13	the	the	DET
ctmj-149	283	14	doi	doi	NOUN
ctmj-149	283	15	:	:	PUNCT
ctmj-149	283	16	136	136	NUM
ctmj-149	283	17	.	.	PUNCT
ctmj-149	284	1	48	48	NUM
ctmj-149	284	2	.	.	PUNCT
ctmj-149	285	1	stati	stati	PROPN
ctmj-149	285	2	s.v	s.v	PROPN
ctmj-149	285	3	.	.	PROPN
ctmj-149	285	4	when	when	SCONJ
ctmj-149	285	5	administered	administer	VERB
ctmj-149	285	6	to	to	ADP
ctmj-149	285	7	mdck	mdck	VERB
ctmj-149	285	8	epithelial	epithelial	ADJ
ctmj-149	285	9	cells	cell	NOUN
ctmj-149	285	10	,	,	PUNCT
ctmj-149	285	11	protein	protein	NOUN
ctmj-149	285	12	kinase	kinase	PROPN
ctmj-149	285	13	inhibitors	inhibitor	NOUN
ctmj-149	285	14	stop	stop	VERB
ctmj-149	285	15	the	the	DET
ctmj-149	285	16	dissociation	dissociation	NOUN
ctmj-149	285	17	of	of	ADP
ctmj-149	285	18	junctions	junction	NOUN
ctmj-149	285	19	caused	cause	VERB
ctmj-149	285	20	by	by	ADP
ctmj-149	285	21	low	low	ADJ
ctmj-149	285	22	extracellular	extracellular	ADJ
ctmj-149	285	23	calcium	calcium	NOUN
ctmj-149	285	24	.	.	PUNCT
ctmj-149	286	1	herrsch	herrsch	PROPN
ctmj-149	286	2	m	m	PROPN
ctmj-149	286	3	,	,	PUNCT
ctmj-149	286	4	noske	noske	PROPN
ctmj-149	286	5	w.	w.	PROPN
ctmj-149	286	6	cited	cite	VERB
ctmj-149	286	7	in	in	ADP
ctmj-149	286	8	j	j	PROPN
ctmj-149	286	9	cell	cell	NOUN
ctmj-149	286	10	biol	biol	NOUN
ctmj-149	286	11	.	.	PUNCT
ctmj-149	287	1	1992	1992	NUM
ctmj-149	287	2	,	,	PUNCT
ctmj-149	287	3	117	117	NUM
ctmj-149	287	4	:	:	SYM
ctmj-149	287	5	117–169	117–169	NUM
ctmj-149	287	6	.	.	PUNCT
ctmj-149	287	7	structure	structure	NOUN
ctmj-149	287	8	and	and	CCONJ
ctmj-149	287	9	function	function	NOUN
ctmj-149	287	10	at	at	ADP
ctmj-149	287	11	the	the	DET
ctmj-149	287	12	tight	tight	ADJ
ctmj-149	287	13	juncture	juncture	NOUN
ctmj-149	287	14	.	.	PUNCT
ctmj-149	288	1	electron	electron	PROPN
ctmj-149	288	2	.	.	PUNCT
ctmj-149	289	1	1993;24:325–352	1993;24:325–352	NOUN
ctmj-149	289	2	.	.	PROPN
ctmj-149	289	3	50	50	NUM
ctmj-149	289	4	.	.	PUNCT
ctmj-149	289	5	velarde	velarde	PROPN
ctmj-149	289	6	g	g	PROPN
ctmj-149	289	7	,	,	PUNCT
ctmj-149	289	8	aitaissa	aitaissa	NOUN
ctmj-149	289	9	s	s	PART
ctmj-149	289	10	,	,	PUNCT
ctmj-149	289	11	gillet	gillet	PROPN
ctmj-149	289	12	c	c	PROPN
ctmj-149	289	13	,	,	PUNCT
ctmj-149	289	14	et	et	PROPN
ctmj-149	289	15	al	al	PROPN
ctmj-149	289	16	.	.	PROPN
ctmj-149	289	17	examination	examination	NOUN
ctmj-149	289	18	of	of	ADP
ctmj-149	289	19	pentachlorophenol	pentachlorophenol	NOUN
ctmj-149	289	20	toxicity	toxicity	NOUN
ctmj-149	289	21	by	by	ADP
ctmj-149	289	22	the	the	DET
ctmj-149	289	23	use	use	NOUN
ctmj-149	289	24	of	of	ADP
ctmj-149	289	25	transepithelial	transepithelial	ADJ
ctmj-149	289	26	electrical	electrical	ADJ
ctmj-149	289	27	resistance	resistance	NOUN
ctmj-149	289	28	.	.	PUNCT
ctmj-149	290	1	in	in	ADP
ctmj-149	290	2	vitro	vitro	X
ctmj-149	290	3	toxicology	toxicology	NOUN
ctmj-149	290	4	,	,	PUNCT
ctmj-149	290	5	1999	1999	NUM
ctmj-149	290	6	,	,	PUNCT
ctmj-149	290	7	13	13	NUM
ctmj-149	290	8	,	,	PUNCT
ctmj-149	290	9	723–727.mcginn	723–727.mcginn	NUM
ctmj-149	290	10	mt	mt	PROPN
ctmj-149	290	11	and	and	CCONJ
ctmj-149	290	12	mullin	mullin	PROPN
ctmj-149	290	13	jm	jm	PROPN
ctmj-149	290	14	.	.	PROPN
ctmj-149	290	15	diacylglycerol	diacylglycerol	PROPN
ctmj-149	290	16	effects	effect	NOUN
ctmj-149	290	17	on	on	ADP
ctmj-149	290	18	llc	llc	PROPN
ctmj-149	290	19	-	-	PUNCT
ctmj-149	290	20	pk1	pk1	PROPN
ctmj-149	290	21	renal	renal	ADJ
ctmj-149	290	22	epithelia	epithelia	PROPN
ctmj-149	290	23	:	:	PUNCT
ctmj-149	290	24	similarities	similarity	NOUN
ctmj-149	290	25	with	with	ADP
ctmj-149	290	26	phorbol	phorbol	ADJ
ctmj-149	290	27	ester	ester	NOUN
ctmj-149	290	28	tumour	tumour	NOUN
ctmj-149	290	29	promoters	promoter	NOUN
ctmj-149	290	30	examined	examine	VERB
ctmj-149	290	31	.	.	PUNCT
ctmj-149	291	1	gutbiner	gutbiner	NOUN
ctmj-149	291	2	and	and	CCONJ
ctmj-149	291	3	simons	simon	NOUN
ctmj-149	291	4	(	(	PUNCT
ctmj-149	291	5	1998	1998	NUM
ctmj-149	291	6	)	)	PUNCT
ctmj-149	291	7	published	publish	VERB
ctmj-149	291	8	in	in	ADP
ctmj-149	291	9	the	the	DET
ctmj-149	291	10	journal	journal	NOUN
ctmj-149	291	11	of	of	ADP
ctmj-149	291	12	cell	cell	NOUN
ctmj-149	291	13	physiology	physiology	NOUN
ctmj-149	291	14	,	,	PUNCT
ctmj-149	291	15	volume	volume	NOUN
ctmj-149	291	16	134	134	NUM
ctmj-149	291	17	,	,	PUNCT
ctmj-149	291	18	pages	page	NOUN
ctmj-149	291	19	357–366	357–366	NUM
ctmj-149	291	20	.	.	PUNCT
ctmj-149	292	1	the	the	DET
ctmj-149	292	2	discovery	discovery	NOUN
ctmj-149	292	3	of	of	ADP
ctmj-149	292	4	an	an	DET
ctmj-149	292	5	auvomorulin	auvomorulin	NOUN
ctmj-149	292	6	-	-	PUNCT
ctmj-149	292	7	like	like	ADJ
ctmj-149	292	8	polypeptide	polypeptide	NOUN
ctmj-149	292	9	:	:	PUNCT
ctmj-149	292	10	a	a	DET
ctmj-149	292	11	functional	functional	ADJ
ctmj-149	292	12	test	test	NOUN
ctmj-149	292	13	for	for	ADP
ctmj-149	292	14	proteins	protein	NOUN
ctmj-149	292	15	involved	involve	VERB
ctmj-149	292	16	in	in	ADP
ctmj-149	292	17	the	the	DET
ctmj-149	292	18	establishment	establishment	NOUN
ctmj-149	292	19	of	of	ADP
ctmj-149	292	20	an	an	DET
ctmj-149	292	21	epithelial	epithelial	ADJ
ctmj-149	292	22	occluding	occlude	VERB
ctmj-149	292	23	barrier	barrier	NOUN
ctmj-149	292	24	.	.	PUNCT
ctmj-149	293	1	staddon	staddon	PROPN
ctmj-149	293	2	jm	jm	PROPN
ctmj-149	293	3	,	,	PUNCT
ctmj-149	293	4	herrenknecht	herrenknecht	PROPN
ctmj-149	293	5	k	k	PROPN
ctmj-149	293	6	,	,	PUNCT
ctmj-149	293	7	smales	smale	NOUN
ctmj-149	293	8	c	c	NOUN
ctmj-149	293	9	,	,	PUNCT
ctmj-149	293	10	and	and	CCONJ
ctmj-149	293	11	rubin	rubin	PROPN
ctmj-149	293	12	ll	ll	AUX
ctmj-149	293	13	published	publish	VERB
ctmj-149	293	14	a	a	DET
ctmj-149	293	15	paper	paper	NOUN
ctmj-149	293	16	in	in	ADP
ctmj-149	293	17	the	the	DET
ctmj-149	293	18	journal	journal	NOUN
ctmj-149	293	19	of	of	ADP
ctmj-149	293	20	cell	cell	NOUN
ctmj-149	293	21	biology	biology	NOUN
ctmj-149	293	22	in	in	ADP
ctmj-149	293	23	1986	1986	NUM
ctmj-149	293	24	,	,	PUNCT
ctmj-149	293	25	volume	volume	NOUN
ctmj-149	293	26	102	102	NUM
ctmj-149	293	27	,	,	PUNCT
ctmj-149	293	28	pages	page	NOUN
ctmj-149	293	29	436	436	NUM
ctmj-149	293	30	-	-	SYM
ctmj-149	293	31	468	468	NUM
ctmj-149	293	32	.	.	PUNCT
ctmj-149	294	1	proof	proof	NOUN
ctmj-149	294	2	that	that	PRON
ctmj-149	294	3	phosphorylation	phosphorylation	NOUN
ctmj-149	294	4	of	of	ADP
ctmj-149	294	5	tyrosine	tyrosine	NOUN
ctmj-149	294	6	may	may	AUX
ctmj-149	294	7	enhance	enhance	VERB
ctmj-149	294	8	the	the	DET
ctmj-149	294	9	permeability	permeability	NOUN
ctmj-149	294	10	of	of	ADP
ctmj-149	294	11	tight	tight	ADJ
ctmj-149	294	12	junctions	junction	NOUN
ctmj-149	294	13	.	.	PUNCT
ctmj-149	295	1	j	j	PROPN
ctmj-149	295	2	cell	cell	PROPN
ctmj-149	295	3	sci	sci	PROPN
ctmj-149	295	4	.	.	PUNCT
ctmj-149	295	5	1995;108:609–619	1995;108:609–619	X
ctmj-149	296	1	53	53	NUM
ctmj-149	296	2	.	.	PUNCT
ctmj-149	297	1	niessen	niessen	PROPN
ctmj-149	297	2	cm	cm	PROPN
ctmj-149	297	3	.	.	PUNCT
ctmj-149	298	1	adherens	adherens	PROPN
ctmj-149	298	2	junctions	junction	NOUN
ctmj-149	298	3	and	and	CCONJ
ctmj-149	298	4	tight	tight	ADJ
ctmj-149	298	5	junctions	junction	NOUN
ctmj-149	298	6	:	:	PUNCT
ctmj-149	298	7	structure	structure	NOUN
ctmj-149	298	8	and	and	CCONJ
ctmj-149	298	9	function	function	NOUN
ctmj-149	298	10	at	at	ADP
ctmj-149	298	11	a	a	DET
ctmj-149	298	12	fundamental	fundamental	ADJ
ctmj-149	298	13	level	level	NOUN
ctmj-149	298	14	.	.	PUNCT
ctmj-149	299	1	journal	journal	NOUN
ctmj-149	299	2	of	of	ADP
ctmj-149	299	3	the	the	DET
ctmj-149	299	4	american	american	PROPN
ctmj-149	299	5	academy	academy	PROPN
ctmj-149	299	6	of	of	ADP
ctmj-149	299	7	dermatology	dermatology	NOUN
ctmj-149	299	8	.	.	PUNCT
ctmj-149	300	1	2007;127:2525–2532	2007;127:2525–2532	NUM
ctmj-149	300	2	.	.	PUNCT
ctmj-149	301	1	54	54	NUM
ctmj-149	301	2	.	.	PUNCT
ctmj-149	302	1	turner	turner	PROPN
ctmj-149	302	2	jr	jr	PROPN
ctmj-149	302	3	,	,	PUNCT
ctmj-149	302	4	buschmann	buschmann	PROPN
ctmj-149	302	5	mm	mm	PROPN
ctmj-149	302	6	,	,	PUNCT
ctmj-149	302	7	romero	romero	PROPN
ctmj-149	302	8	ci	ci	PROPN
ctmj-149	302	9	,	,	PUNCT
ctmj-149	302	10	sailer	sailer	NOUN
ctmj-149	302	11	a	a	NOUN
ctmj-149	302	12	,	,	PUNCT
ctmj-149	302	13	shen	shen	PROPN
ctmj-149	302	14	l.	l.	PROPN
ctmj-149	302	15	the	the	DET
ctmj-149	302	16	function	function	NOUN
ctmj-149	302	17	of	of	ADP
ctmj-149	302	18	molecular	molecular	ADJ
ctmj-149	302	19	remodelling	remodelling	NOUN
ctmj-149	302	20	in	in	ADP
ctmj-149	302	21	the	the	DET
ctmj-149	302	22	control	control	NOUN
ctmj-149	302	23	of	of	ADP
ctmj-149	302	24	tight	tight	ADJ
ctmj-149	302	25	junction	junction	NOUN
ctmj-149	302	26	permeability	permeability	NOUN
ctmj-149	302	27	via	via	ADP
ctmj-149	302	28	differential	differential	ADJ
ctmj-149	302	29	mechanisms	mechanism	NOUN
ctmj-149	302	30	.	.	PUNCT
ctmj-149	303	1	publication	publication	NOUN
ctmj-149	303	2	:	:	PUNCT
ctmj-149	303	3	semin	semin	PROPN
ctmj-149	303	4	cell	cell	PROPN
ctmj-149	303	5	dev	dev	PROPN
ctmj-149	303	6	biol	biol	NOUN
ctmj-149	303	7	.	.	PUNCT
ctmj-149	304	1	2014;36	2014;36	X
ctmj-149	304	2	:	:	PUNCT
ctmj-149	304	3	204–212	204–212	NUM
ctmj-149	304	4	.	.	PUNCT
ctmj-149	305	1	55	55	NUM
ctmj-149	305	2	.	.	PUNCT
ctmj-149	306	1	ciara	ciara	PROPN
ctmj-149	306	2	cm	cm	PROPN
ctmj-149	306	3	.	.	PUNCT
ctmj-149	307	1	the	the	DET
ctmj-149	307	2	transepithelial	transepithelial	ADJ
ctmj-149	307	3	electrical	electrical	ADJ
ctmj-149	307	4	resistance	resistance	NOUN
ctmj-149	307	5	of	of	ADP
ctmj-149	307	6	cell	cell	NOUN
ctmj-149	307	7	layers	layer	NOUN
ctmj-149	307	8	cultivated	cultivate	VERB
ctmj-149	307	9	on	on	ADP
ctmj-149	307	10	permeable	permeable	ADJ
ctmj-149	307	11	filters	filter	NOUN
ctmj-149	307	12	may	may	AUX
ctmj-149	307	13	be	be	AUX
ctmj-149	307	14	affected	affect	VERB
ctmj-149	307	15	by	by	ADP
ctmj-149	307	16	another	another	DET
ctmj-149	307	17	factor	factor	NOUN
ctmj-149	307	18	,	,	PUNCT
ctmj-149	307	19	cellsubstrate	cellsubstrate	ADJ
ctmj-149	307	20	interaction	interaction	NOUN
ctmj-149	307	21	.	.	PUNCT
ctmj-149	308	1	publication	publication	NOUN
ctmj-149	308	2	date	date	NOUN
ctmj-149	308	3	:	:	PUNCT
ctmj-149	308	4	1999	1999	NUM
ctmj-149	308	5	and	and	CCONJ
ctmj-149	308	6	the	the	DET
ctmj-149	308	7	volume	volume	NOUN
ctmj-149	308	8	number	number	NOUN
ctmj-149	308	9	:	:	PUNCT
ctmj-149	308	10	250	250	NUM
ctmj-149	308	11	,	,	PUNCT
ctmj-149	308	12	pages	page	NOUN
ctmj-149	308	13	576–580	576–580	NUM
ctmj-149	308	14	.	.	PUNCT
ctmj-149	308	15	number	number	NOUN
ctmj-149	308	16	56	56	NUM
ctmj-149	308	17	:	:	PUNCT
ctmj-149	308	18	chen	chen	PROPN
ctmj-149	308	19	xl	xl	PROPN
ctmj-149	308	20	,	,	PUNCT
ctmj-149	308	21	lu	lu	PROPN
ctmj-149	308	22	y	y	PROPN
ctmj-149	308	23	,	,	PUNCT
ctmj-149	308	24	du	du	PROPN
ctmj-149	308	25	sy	sy	PROPN
ctmj-149	308	26	,	,	PUNCT
ctmj-149	308	27	zhao	zhao	PROPN
ctmj-149	308	28	xj	xj	PROPN
ctmj-149	308	29	,	,	PUNCT
ctmj-149	308	30	li	li	PROPN
ctmj-149	308	31	py	py	PROPN
ctmj-149	308	32	.	.	PUNCT
ctmj-149	309	1	research	research	NOUN
ctmj-149	309	2	comparing	compare	VERB
ctmj-149	309	3	the	the	DET
ctmj-149	309	4	pharmacokinetics	pharmacokinetic	NOUN
ctmj-149	309	5	of	of	ADP
ctmj-149	309	6	tongqiaosanyu	tongqiaosanyu	NOUN
ctmj-149	309	7	formula	formula	NOUN
ctmj-149	309	8	administered	administer	VERB
ctmj-149	309	9	by	by	ADP
ctmj-149	309	10	various	various	ADJ
ctmj-149	309	11	routes	route	NOUN
ctmj-149	309	12	to	to	ADP
ctmj-149	309	13	the	the	DET
ctmj-149	309	14	brain	brain	NOUN
ctmj-149	309	15	and	and	CCONJ
ctmj-149	309	16	plasma	plasma	NOUN
ctmj-149	309	17	.	.	PUNCT
ctmj-149	310	1	journal	journal	NOUN
ctmj-149	310	2	of	of	ADP
ctmj-149	310	3	traditional	traditional	ADJ
ctmj-149	310	4	chinese	chinese	ADJ
ctmj-149	310	5	medicine	medicine	NOUN
ctmj-149	310	6	,	,	PUNCT
ctmj-149	310	7	2014	2014	NUM
ctmj-149	310	8	,	,	PUNCT
ctmj-149	310	9	29	29	NUM
ctmj-149	310	10	,	,	PUNCT
ctmj-149	310	11	2668	2668	NUM
ctmj-149	310	12	–	–	PUNCT
ctmj-149	310	13	2672	2672	NUM
ctmj-149	310	14	.	.	PUNCT
ctmj-149	311	1	from	from	ADP
ctmj-149	311	2	the	the	DET
ctmj-149	311	3	chinese	chinese	ADJ
ctmj-149	311	4	language	language	NOUN
ctmj-149	311	5	.	.	PUNCT
ctmj-149	312	1	authors	author	NOUN
ctmj-149	312	2	:	:	PUNCT
ctmj-149	312	3	li	li	PROPN
ctmj-149	312	4	py	py	PROPN
ctmj-149	312	5	,	,	PUNCT
ctmj-149	312	6	lu	lu	PROPN
ctmj-149	312	7	y	y	PROPN
ctmj-149	312	8	,	,	PUNCT
ctmj-149	312	9	du	du	PROPN
ctmj-149	312	10	sy	sy	PROPN
ctmj-149	312	11	,	,	PUNCT
ctmj-149	312	12	and	and	CCONJ
ctmj-149	312	13	cen	cen	PROPN
ctmj-149	312	14	xl	xl	PROPN
ctmj-149	312	15	.	.	PUNCT
ctmj-149	313	1	the	the	DET
ctmj-149	313	2	in	in	ADV
ctmj-149	313	3	vitro	vitro	X
ctmj-149	313	4	study	study	NOUN
ctmj-149	313	5	of	of	ADP
ctmj-149	313	6	puerarin	puerarin	ADJ
ctmj-149	313	7	mucosal	mucosal	NOUN
ctmj-149	313	8	permeability	permeability	NOUN
ctmj-149	313	9	as	as	SCONJ
ctmj-149	313	10	it	it	PRON
ctmj-149	313	11	relates	relate	VERB
ctmj-149	313	12	to	to	PART
ctmj-149	313	13	menthol	menthol	VERB
ctmj-149	313	14	.	.	PUNCT
ctmj-149	314	1	chinese	chinese	ADJ
ctmj-149	314	2	pharmaceutical	pharmaceutical	PROPN
ctmj-149	314	3	journal	journal	PROPN
ctmj-149	314	4	2012;23	2012;23	NUM
ctmj-149	314	5	:	:	PUNCT
ctmj-149	314	6	4425–4427	4425–4427	NUM
ctmj-149	314	7	.	.	PUNCT