Case Study.cdr ISSN : 2693 6356 2018 | Vol 1 | Issue 4 Necrotizing fasciitis: a case study of the use of the Ayurvedic treatments ksharakarma (caustic cauterization) and jalukavacharana (hirudotherapy). Rajesh V Giri * * Professor and Head, Department of Post Graduate Studies in Shalyatantra, Muniyal Institute of Ayurveda Medical Science, Manipal, chanai Abstract An invasive infection of the skin and soft tissues, including the deep fascia, necrotizing fascitis, with relative sparing of the muscle. The treatment plan often includes removing the diseased tissue or maybe amputating the limb. The purpose of this study is to compare the efficacy of Ksharakarma (caustic cautery) and Jalukavacharana (hirudotherapy) in the treatment of necrotizing fascitis to that of surgical intervention. Substances and Techniques: Kshara was used on a case of an infected wound at the tip of the right index nger until enough debridement of slough occurred, and then Jalukavacharana was used to speed up tissue perfusion to the wound site and hasten the healing process. After 15 days, the necrotized region had been totally debrided (in two Ksharakarma sessions) and healed (in three Jalukavacharana sessions), preventing the need for surgical amputation of the terminal phalanx. The necrotizing fascitis wound was successfully managed by Ksharakarma and Jalukavacharana, preventing the need for amputation. Keywords: Necrotizing fasciitis, gangrene, hirutotherapy, jalukavacharana, ksharakarma, and caustic cauterization Introduction since ages, management of injuries has been a challenge to the surgeons of medical Tissue injury in the form of wounds caused by vehicular accidents, warfare, animal attacks or ulcers caused due to various diseases, have always posed challenges to the practitioners of medicine. Ayurveda, especially, the branch of Shalyatantra (surgery). The various management methods explained by Sushrutha in validity even in this century. Traumatic wounds as a consequence to animal attacks and warfare (Abhighataja vrana) and ulcers due to various pathologies (Nija vrana) were observed and recorded in a detailed manner by Ayurveda. The management of which posed a great challenge to the surgeons of Ayurveda in ancient period. Giving due importance, wound management has been described under the branch of Shalyatantra [1]. A great in-depth description is available in Sushrutha Samhita (Text book by Sushrutha) regarding traumatic wounds, ulcers, their causes, examination methods and clinical features, signs of a clean wound, signs of a healing wound, signs of a healed wound, signs of infected wound, signs of chronic infected wounds and gangrenous wounds [2].Sushrutha Samhita describes 60 therapeutic methods [3] for the management of a wound/ulcer, right from the stage of abscess till the cosmetic repair of the formed scar (after healing). The present case study has been undertaken as a preliminary effort to re-validate the therapeutic modules explained by Acharya Sushrutha in the management of an Ulcer (Necrotising fasciitis).Caustic cautery or Ksharakarma is one of the important methods mentioned for the early non-surgical debridement of slough from the wound site. Ksharakarma is considered as a superior treatment module as it not only has a unique effect of managing all the vitiated three Dosha, but also has the ability to perform various surgical procedures like Chedana (excision), Bhedana (incision) etc without the actual necessity of any surgical instruments. The caustics extracted from the plant – Apamarga (Achyranthes aspera) and various other Ayurvedic ingredients have a potent antibacterial property against Escherichia coli, Enterococcus faecalis, Staphylococcus aureus and Pseudomonas species [4]. Thus caustic cautery has a potent antibiotic property and also debrides the dead, necrotising slough from the wound non-surgically. Its role in the form of Ksharasutra (medicated seton) has already been proved to be highly effective in the management of in ano[5]. Hirudotherapy (Jalukavacharana or therapeutic application of leeches) has been mentioned as one of the non-surgical methods of removal of located Gratitha (coagulated or blocked vessels) Rakta and thus the area. Hirudotherapy by its anti-coagulant salivary secretions promotes micro-circulation of fresh blood into the tissues and removes venous obstructions, thus reducing venous congestion [6]. Case Study In the present study, a girl, aged 14 years, presented at the Shalyatantra OPD of the Hospital, with an infected wound at the tip of right index with distal portions gangrenous 1). There was foul smelling discharge and pain in the nail bed – since 20 days with the local tissue around the nail bed was fast turning dark 2) and the nail was turning brittle. around the nail bed of the Fig 1:Non-healing wound Fig 2: Darkened tissue with gangrenous portions On taking a detailed history, about 20 days back, she complained of pain in the tip of right index with an associated mild swelling and fever. A local physician, diagnosing it as an abscess, conducted Incision and Drainage, and advised analgesics and antibiotics. But within a day, the swelling increased and blackish discoloration appeared. On visiting another surgeon, the case was diagnosed as a case of Necrotising fascitis. I & D was again done, and thick creamy pus was drained and abscess cavity was found to reach bone. After thorough debridement and toileting, abscess cavity was packed with betadine and was advised IV antibiotics, 12 hourly. Pus culture showed presence of heavy Staphylococcus aureus growth. Radiography clearly ruled out any osteomyelitis of the distal phalanx of the index On referral to a Plastic and Reconstructive, Hand and Burns Surgeon, she was advised amputation of distal advised from the neighboring To avoid amputation and loss of most useful part of the more importantly to she approached for an alternative to amputation. After educating the patient regarding the treatment modalities available, and taking consent from her mother, she was put on caustic cautery and hirudotherapy measures. Treatment History: washed with distillate of Cow's urine and then, Apamarga Teekshna Kshara was applied and left in situ for about 1 minute. The area was then washed with lemon juice (to neutralize Kshara) and a Pichu dipped in Jathyadi Taila was placed on the site. Ksharakarma does Ksharana and Kshanana karma i.e. debrides and removes slough or the devitalized tissue from the site. Hence care was taken to do Ksharakarma only till slough was present in the site. Two sittings of Ksharakarma were done on alternate days, followed by three sittings of Jalukavacharana on alternate days. After cleaning the area with warm water, one fresh leech was applied to the site for 15 minutes During the procedure, the leech was covered with a thin piece of cotton soaked in water to keep the leech moist. After the passage of 15 minutes, leech was removed by sprinkling turmeric powder on its anterior sucker. The site was then covered with a Pichu dipped in Jathyadi taila and bandaged tightly. Fig 3: Hirudotherapy on the non-healing wound Oral medications 1. Tab. Munibyeotic 2 TID after food Table. 5: Grading of granulation tissue in the wound Granulation tissue Grade Healthy granulation tissue in the complete 0 wound Unhealthy granulation in 25% of the wound 1 area Unhealthy granulation in 25-50% of the 2 wound area Unhealthy granulation in more than 50% of 3 the wound area Assessment of results 2. Mahamanjishtadi Kashaya 30 ml BD with equal water, before food was advised Duration of the study Duration of study was for 15 days, during which on alternate days, she underwent two sittings of Ksharakarma , followed by three sittings of Jalukavacharana.Assessment of the results was made based on the above mentioned criteria and Follow up 1 as F1, Follow up 2 as F2 and so on, on alternate days. Results: During the treatment it was observed that from the 3rd follow up the pain started reducing and by the end ofw up the pain had becoly Assessment criteria a.Subjective criteria–Pain (table 1) Table 1: Grading of pain Pain Grade No pain 0 Tolerable localized pain 1 Pain requires analgesics 2 Pain even during rest, disturbing the sleep 3 b.Objective criteria–Size of the wound (table 2), odor (table 3), discharge (table 4), granulation tissue (table 5) Table.2: Grading of the size of the wound Size of the wound Grade Completely healed wound 0 Up to 0.5cm 1 0.6 – 1 cm 2 1.1 – 1.5cms 3 Table. 3: Grading of odor of the wound Odor Grade No odor 0 Foul odor 1 Table. 4: Grading of discharge from the wound Discharge Grad e No discharge, dry dressing 0 Scanty discharge, little wet dressing 1 Moderate discharge, requires daily dressing 2 Profuse discharge, requires dressing twice a 3 day relieved, indicating that the therapy had a good healing property (table 6). The caustic cautery and hirudotherapy, reduced infection, pus and slough and along with distillate of cow's urine prevented re- infection of the wound and thus helped in the early relief in pain. Till the 3rd follow up , though there were other changes, the wound size continued to be the same, and later there was good reduction and by the end of the 7th follow up the wound had completely reduced in size. After the slough, infected material had been debrided by caustic cautery, cow's urine, hirudotherapy and Jathyadi Taila, reduced venous congestion, improved micro-circulation and thus oxygenation might have supported early wound healing (table 6). The odor from the wound reduced by the 4th follow up. Caustic cautery along with distillate of cow's urine, helped to control infection. Controlled infection along with improved oxygenation to the tissue (through hirudotherapy) might have helped in early reduction in the odor from the wound (table 6). The most interesting was till the 4th follow up the discharge was constantly on the higher side, with improvement in other parameters. This indicates towards the debriding action of the caustics used in the therapy. Caustics used could debride the slough from the wound without the necessity of any surgical intervention. Fig 4: 3rd follow-up Fig 5: 4th follow-up Fig 6: 5th follow-up Fig 7: 6rd follow-up There was a gradual decrease in the quantity of unhealthy granulation tissue in each follow up to be completely removed by the seventh follow up 5-11). This reduction in unhealthy debriding action of improved blood supply to the area. This reasserts the role of hirudotherapy and Jathyadi Taila in healing the wound (table 6). Table 6: Grade wise representation of therapeutic effect on assessment parametersFigure 8: 7th follow-up Figure 9: 7th follow-up Figure 10: 1 month after Figure 11: 1 month after the 8th follow up the 8th follow up Discussion The Gomutra Arka (Distillate of Cow's urine) has good antimicrobial property[7]. Hence it was used for washing the wound site. Various studies have also already proved that the Kshara of Achyranthes aspera has antibacterial property against Escherichia coli, Enterococcus faecalis, Staphylococcus aureus and Pseudomonas species [4]. The Kshara debrided the gangrenous slough and along with Gomutra Arka provided a clean environment for the wound to heal. Jalukavacharana by stimulating micro-circulation and Assessment reducing venous congestion improved oxygen and nutrients perfusion to the healing tissues thus promoting the clean wound to heal [6]. Jathyadi Taila, the topical application also supported the faster wound healing [ 8] . Jati mainly contains tannins. Tannins have the capacity to combine with tissue protein and precipitate them. They act as mild antiseptics and check small hemorrhages; forms protective covering on the surface of wound, which helps in the process of wound healing [9]. Tab. Munibyeotic with its ingredients Triphala, Pippali, Shuddha Guggulu, Swarna Makshika Bhasma, Mukta shukti Bhasma, Shuddha Gairika, Kapardika Bhasma, Gandhaka Rasayana, Nimba Twak, Haridra – possesses immunomodulatory, antioxidant, anti- and anti- microbial properties, s t imulatesphagocytosis, increases the level of antibody-forming cells and also specially sensitizes T lymphocytes. Conclusion The procedures have revealed encouraging results in the management of infected, gangrenous wounds. Their therapeutic application needs to be reassessed in a larger sample of cases and in gangrene of various etiologies viz, gangrene secondary to diabetic ulcer, gangrene secondary to arterial diseases in order to observe if the limb can be saved from amputation, thus providing a superior relief to the patient medically as well as psychologically. References 1. S u s h r u t a , S u s h r u t a s a m h i t a , Vedotpatthiadhyaya, Sutra Sthana, Chapter 1, Verse 9, edited by Ambikadatta Shastry, 12th ed. Varanasi; Chaukambha Sanskrit Sansthan; 2001, p. 3 2. S u s h r u t a , S u s h r u t a s a m h i t a , Vranasravavijnaniyamadhyaya, Sutra Sthana, Chapter 22, Verse 7, edited by Ambikadatta Shastry, 12th ed. Varanasi; Chaukambha Sanskrit Sansthan; 2001, p. 95 3. S u s h r u t a , S u s h r u t a s a m h i t a , Dvivraniyachikitsitamadhyaya, Chikitsa Sthana, Chapter 1, Verse 8, edited by Ambikadatta Shastry, 12th ed. Varanasi; Chaukambha Sanskrit Sansthan; 2001, p. 4 4. Rajneesh V Giri, Standardization and Evaluation of Guggulu based Kshara Sutra in Thesis, IMS, Banaras Hindu University, 2003. 5. sutra (medicated seton) therapy in the management of -in-ano, World Journal of Colorectal Surgery 2010; 2(2) (Art.6:01-10) 6. Conforti M L, Connor N P, Heisey D M, Hartig G K , E v a l u a t i o n o f p e r f o r m a n c e characteristics of the medicinal leech for the treatment of venous congestion, Plast Reconstr Surg 2002:109:228-235 7. Anami Ahuja, Pushpander Kumar et al, Antimicrobial activities of Cow Urine against various Bacterial strains, International Journal of Recent Advances in Pharmaceutical Research April 2012; 2(2): 84-87 8. Dhande Priti P, Raj Simpy et al, Burn wound healing potential of Jatyadi Formulations in rats, Research Journal of Pharmaceutical, Biological and Chemical Sciences, Oct-Dec 2012; 3(4): 747