id	author	title	date	pages	extension	mime	words	sentence	flesch	summary	cache	txt
cuesj-179	Luaibi, Noori M.; Zayed, Noor A.	Investigation of the Zinc Oxide Nanoparticles Effect on Thyroid and Testosterone Hormones in Male Rats	2020	6	.pdf	application/pdf	4809	229	56	It is considered one of the main regulators of biological processes, during development, and childhood.[9] Decrease in the production of thyroid hormones means hypothyroidism.[10] Many evidence suggesting the role of zinc in the formation and function of thyroid hormones.[11] ZnO NPs cause higher levels of oxidative stress, resulting in inflammation, and cell toxicity.[12] Man testis has two main functions, the production of testosterone and the production of male germ cells, maintenance of spermatogenesis process needs testosterone, the androgen production is regulated by luteinizing hormone, while follicle-stimulating hormone is critical for initiation and maintenance of spermatogenesis.[13,14] Testosterone is the main androgenic hormone in males, it is largely produced by the Leydig cells of the testes, ZnO NPs were internalized by Sertoli cells and Leydig cells resulted in cytotoxicity in a time and dose-dependent manner through the induction of apoptosis, caused by increase in ROS related with loss of Corresponding Author: Noori M. Luaibi, Department of Biology, College of Sciences, University of Al-Mustansiriyah, Baghdad, Iraq. Ng/dl. DISCUSSION Results of the present study are in agreement with previous study of ZnO NPs by Cheric and Rafieirad[20] showed that injecting ZnO NPs with three different doses (1.25, 2.5, and 5) mg/kg to 42 male rats divided into 7 groups, the blood samples of experimental with different doses were taken on the 1st, 3rd, 4th, and 15th days after receiving Nano ZnO intraperitoneally (ip) to measure the amount of T3 and T4 hormone levels, results observed that acute injection of Nano ZnO reduced the amount of thyroid hormone T3 and T4, the effect occurred in different doses, but is more significant in the medium and long term, even in small amounts can cause negative effects on the activity of the thyroid gland and disrupt creation of thyroid hormones.	cache/cuesj-179.pdf	txt/cuesj-179.txt