item: #1 of 235 id: cord-001381-b0tlco4t author: Howie, Stephen R. C. title: Etiology of Severe Childhood Pneumonia in The Gambia, West Africa, Determined by Conventional and Molecular Microbiological Analyses of Lung and Pleural Aspirate Samples date: 2014-09-01 words: 2362 flesch: 40 summary: Pneumonia etiologic studies have depended largely on blood culture, which is insensitive [2] . A better understanding of the range of pneumonia pathogens is needed to reduce child mortality further [1] , but this is hampered by limitations at the bedside and in the laboratory. keywords: children; influenzae; lung; pathogens; pneumonia; samples; study cache: cord-001381-b0tlco4t.txt plain text: cord-001381-b0tlco4t.txt item: #2 of 235 id: cord-001800-644lf8vn author: Biggerstaff, Matthew title: Estimating the Potential Effects of a Vaccine Program Against an Emerging Influenza Pandemic—United States date: 2015-05-01 words: 4495 flesch: 36 summary: Also important is the need to identify ways to invest in improvements that will notably increase the capacity to administer large number of doses of pandemic influenza vaccine. Factors that may impact vaccine dose availability include how soon we develop an appropriate vaccine virus candidate, growth characteristics of vaccine virus candidates, influenza vaccine production capacity, efficiency of vaccine allocation and distribution, and vaccine administration capacity. keywords: doses; hospitalizations; influenza; pandemic; vaccine; weeks cache: cord-001800-644lf8vn.txt plain text: cord-001800-644lf8vn.txt item: #3 of 235 id: cord-002514-pp06m5xk author: Venkatesan, Sudhir title: Impact of Outpatient Neuraminidase Inhibitor Treatment in Patients Infected With Influenza A(H1N1)pdm09 at High Risk of Hospitalization: An Individual Participant Data Metaanalysis date: 2017-05-15 words: 4020 flesch: 36 summary: This was confirmed in recent IPD analysis of seasonal influenza patients that reported a risk reduction of 63% in treated patients (intention-to-treat infected population) These data suggest that community patients with severe influenza should receive NAI treatment. to 2009 also suggests that NAIs given to high-risk community patients with influenza may reduce subsequent hospitalization keywords: community; data; hospitalization; influenza; nai; patients; study; treatment cache: cord-002514-pp06m5xk.txt plain text: cord-002514-pp06m5xk.txt item: #4 of 235 id: cord-007047-7ty9mxa9 author: Reller, L. Barth title: Implications of New Technology for Infectious Diseases Practice date: 2006-11-15 words: 4096 flesch: 32 summary: The use of laboratory tests for diagnosis of enteroviral CNS disease was shown to be cost effective long ago [8] , but the availability of rapid molecular tests for this purpose has been long coming. The clinical relevance of 'CSF viral culture': a two-year experience with aseptic meningitis in A rapid and highly accurate assay for the detection of enterovirus infections in cerebrospinal fluid samples using the GeneXpert Dx system Impact of human immunodeficiency virus type 1 (HIV-1) genetic diversity on performance of four commercial viral load assays: LCx HIV RNA Quantitative, AM-PLICOR HIV-1 MONITOR v1.5, VERSANT HIV-1 RNA 3.0, and NucliSens HIV-1 QT Comparing first-void urine specimens, self-collected vaginal swabs, and endocervical specimens to detect Chlamydia trachomatis and Neisseria gonorrhoeae by a nucleic acid amplification test Comparison of methods for detection of Chlamydia trachomatis and Neisseria gonorrhoeae using commercially available nucleic acid amplification tests and a liquid pap smear medium Validation of molecular-diagnostic techniques in the parasitological laboratory Diagnostic PCR: validation and sample preparation are two sides of the same coin Failure of commercial ligase chain reaction to detect Mycobacterium tuberculosis DNA in sputum samples from a patient with smear-positive pulmonary tuberculosis due to a deletion of the target region Reproducibility of positive test results in the BDProbeTec ET system for detection of Chlamydia trachomatis and Neisseria gonorrhoeae False-positive Gen-Probe direct Mycobacterium tuberculosis amplification test results for patients with pulmonary M. kansasii and M. avium infections The current status and potential role of laboratory testing to prevent transfusion-transmitted malaria Characteristics of apparently false-negative digene hybrid capture 2 high-risk HPV DNA testing Occurrence and documentation of low-level bacteremia in a community hospital's patient population Comparison of 9 different PCR primers for the rapid detection of severe acute respiratory syndrome coronavirus using 2 RNA extraction methods Comparison of six DNA extraction methods for recovery of fungal DNA as assessed by quantitative PCR Rapid diagnosis of tuberculous meningitis: what is the optimal method? Comparison of conventional bacteriology with nucleic acid amplification (amplified mycobacterium direct test) for diagnosis of tuberculous meningitis before and after inception of antituberculosis chemotherapy The bacteriological diagnosis of tuberculous meningitis Diagnostic accuracy of nucleic acid amplification tests for tuberculous meningitis: a systematic review and meta-analysis Rapid identification of the species of the Bacteroides fragilis group by multiplex PCR assays using group-and species-specific primers Sequence analysis of four Shigella boydii O-antigen loci: implication for Escherichia coli and Shigella relationships Rhinosporidium seeberi: a human pathogen from a novel group of aquatic protistan parasites Lack of serological evidence for Mycoplasma fermentans infection in army Gulf War veterans: a large scale case-control study Mycoplasma fermentans in individuals seropositive and seronegative for HIV-1 Serological responses to mycoplasmas in HIV-infected and non-infected individuals Monitoring of Chlamydia trachomatis infections after antibiotic treatment using RNA detection by nucleic acid sequence based amplification Multicenter study of a rapid molecular-based assay for the diagnosis of group B Streptococcus colonization in pregnant women Comparison of rapid intrapartum screening methods for group B streptococcal vaginal colonization Perinatal screening for group B streptococci: cost-benefit analysis of rapid polymerase chain reaction Risk factors for early-onset group B streptococcal sepsis: estimation of odds ratios by critical literature review Prevention of perinatal group B streptococcal disease: revised guidelines from CDC Centers for Disease Control and Prevention. keywords: acid; diseases; dna; group; laboratory; methods; nucleic; pcr; results; sample; technology; tests cache: cord-007047-7ty9mxa9.txt plain text: cord-007047-7ty9mxa9.txt item: #5 of 235 id: cord-007049-02p8ug67 author: McGeer, Allison title: Let Him Who Desires Peace Prepare for War: United States Hospitals and Severe Acute Respiratory Syndrome Preparedness date: 2004-07-15 words: 1613 flesch: 41 summary: A careful assessment of exposures in SARS outbreaks, particularly those due to superspreading events and transmission despite compliance with isolation precautions, is needed to determine whether airborne spread occurs [10, [13] [2] suggest, these isolation precautions may have benefits that extend to situations beyond SARS outbreaks, it is also true that isolation may have risks, as recently demonstrated by Redelmeier et al. keywords: health; hospitals; patients; respiratory; sars cache: cord-007049-02p8ug67.txt plain text: cord-007049-02p8ug67.txt item: #6 of 235 id: cord-007050-ibmr5bev author: Xu, Wei title: Serological Investigation of Subclinical Influenza A(H7H9) Infection Among Healthcare and Non–Healthcare Workers in Zhejiang Province, China date: 2013-09-15 words: 707 flesch: 45 summary: Human infection with avian influenza A(H7N9) virus in China: update Human infection with a novel avian-origin influenza A (H7N9) virus Origin and diversity of novel H7N9 avian influenza viruses causing human infection Human infections with the emerging avian influenza A H7N9 virus from wet market poultry: clinical analysis and characterisation of viral genome Serologic study for influenza A (H7N9) among high-risk groups in China Novel coronavirus infection-update (Middle East respiratory syndrome-coronavirus) Receptor specificity and erythrocyte binding preferences of avian influenza viruses isolated from India contributed equally to this work. Infection Among Healthcare and Non–Healthcare Workers in Zhejiang Province, China date: 2013-09-15 journal: Clin Infect Dis DOI: 10.1093/cid/cit396 sha: doc_id: keywords: a(h7n9; infection cache: cord-007050-ibmr5bev.txt plain text: cord-007050-ibmr5bev.txt item: #7 of 235 id: cord-007064-nepgttxf author: Chemaly, Roy F title: A Phase II, Randomized, Double-blind, Placebo-Controlled Trial of Presatovir for the Treatment of Respiratory Syncytial Virus Upper Respiratory Tract Infection in Hematopoietic-Cell Transplant Recipients date: 2019-12-03 words: 5041 flesch: 37 summary: Patients with new or worsening respiratory symptoms for ≤7 days, who had been diagnosed with an RSV infection of the upper respiratory tract for ≤6 days, and who were without new abnormalities on a chest X-ray obtained <48 hours from the start of study treatment were eligible to participate. Patients with a specified, documented respiratory virus coinfection within 7 days from the start of study treatment or with another significant respiratory or systemic infection were excluded. keywords: day; inc; patients; placebo; presatovir; recipients; rsv; sciences; study; treatment; virus cache: cord-007064-nepgttxf.txt plain text: cord-007064-nepgttxf.txt item: #8 of 235 id: cord-007068-vcfs41eb author: Moradi, Tony title: Use of Procalcitonin and a Respiratory Polymerase Chain Reaction Panel to Reduce Antibiotic Use via an Electronic Medical Record Alert date: 2019-10-22 words: 3670 flesch: 34 summary: While the electronic medical record (EMR) has been used in various manners for antibiotic stewardship [22, 23] , we are unaware of its use to automate stewardship recommendations for viral respiratory infections. A study by Timbrook and colleagues found low rates of antibiotic discontinuation in patients with positive viral respiratory PCR, negative PCT, or both, which were suggestive of viral etiology. keywords: alert; antibiotic; bpa; days; patients; pcr; pct; therapy cache: cord-007068-vcfs41eb.txt plain text: cord-007068-vcfs41eb.txt item: #9 of 235 id: cord-007073-soov8q3q author: Wang, Claire Y T title: Parechovirus A Infections in Healthy Australian Children During the First 2 Years of Life: A Community-based Longitudinal Birth Cohort Study date: 2019-08-13 words: 3973 flesch: 47 summary: Beyond seroprevalence, few studies describe the epidemiology and clinical characteristics of PeV infections in the community A similar pattern of PeV infection, but with lower incidence rates, was observed in 200 Finnish children enrolled between 1996 and 2007 where by age 12 months 22% had PeV detected in their stools on at least 1 occasion, which increased to 48% approaching their second birthday [15] . keywords: age; children; infections; months; parechovirus; pev; studies cache: cord-007073-soov8q3q.txt plain text: cord-007073-soov8q3q.txt item: #10 of 235 id: cord-007075-sl45z4i0 author: Marty, Francisco M title: A Phase 2b, Randomized, Double-blind, Placebo-Controlled Multicenter Study Evaluating Antiviral Effects, Pharmacokinetics, Safety, and Tolerability of Presatovir in Hematopoietic Cell Transplant Recipients with Respiratory Syncytial Virus (RSV) Infection of the Lower Respiratory Tract date: 2019-12-03 words: 4687 flesch: 37 summary: Patients received presatovir 200 mg (4 × 50 mg tablets) or placebo orally or via nasogastric tube every 4 days (±24 hours) during study visits on days 1, 5, 9, 13, and 17, and were followed through study day 28. Three presatovir-treated patients (10.3%) and 3 placebo-treated patients (10.7%) developed respiratory failure requiring mechanical ventilation through study day 28 (P = 1.0). keywords: day; days; infection; load; patients; placebo; presatovir; rsv; study; treatment; virus cache: cord-007075-sl45z4i0.txt plain text: cord-007075-sl45z4i0.txt item: #11 of 235 id: cord-007170-svsfu7fj author: Richt, J. A. title: Infection with Borna Disease Virus: Molecular and Immunobiological Characterization of the Agent date: 1992-06-17 words: 6144 flesch: 39 summary: Eine vergleichend-pathologische Studie Axonal transport of Borna disease virus along olfactory pathways in spontaneously and experimentally infected rats Seroepidemiologische Untersuchungen zur Bornaschen Krankheit (Ansteckende Gehirn-Riickenmarkentziindung) der Pferde Borna disease: a persistent virus infection of the central nervous system Preliminary studies on the biology of Borna disease virus Molecular characterization of the Borna disease agent Isolation and characterisation of Borna disease agent cDNA clones A Borna virus cDNA encoding a protein recognized by antibodies in humans with behavioral diseases Analysis of Borna disease virus-specific RNAs in infected cells and tissues Replication of Borna disease virus in cell cultures Influence of interferon on persistent infection caused by Borna disease virus in vitro Borna disease, a possible hazard for man? Isolation and characterization of a 14500 molecular weight protein from brains and tissue cultures persistently infected with Borna disease virus Purification and properties of an intranuclear virus-specific antigen from tissues infected with Borna disease virus Atypical dissemination of the highly neurotropic Borna disease virus during persistent infection in cyclosporin A-treated, immunosuppressed rats Antigenetic relationship and further characterization of two major Borna disease virus proteins Behavioral disease in rats caused by immunopathological responses to persistent Borna virus in the brain Pathogenesis of Borna disease in rats: immune-mediated viral ophthalmoencephalopathy causing blindness and behavioral abnormalities Pathogenesis of Borna disease in rats: evidence that intraaxonal spread is the major route for virus dissemination and the determinant for disease incubation Molecular and immunopathological studies of Borna disease virus infection in rats Coronaviruses and their replication Coronavirus transcription: subgenomic mouse hepatitis virus replicative intermediates function in RNA synthesis Minus-strand copies of replicating coronavirus Clinical and histological findings Persistent Borna virus infection in adult hamsters Adaptation of Borna disease virus to the mouse Astrocytes and Schwann cells are virus-host cells in the nervous system of rats with Borna disease Determination of immune cells and expression of major histocompatibility complex class II antigen in encephalitic lesions of experimental Borna disease Replication of Borna disease virus in rats: age-dependent differences in tissue distribution Effect of Borna disease virus infection on athymic rats Inhibition of immunemediated meningoencephalitis in persistently Borna disease virusinfected rats by cyclosporine A Spread of infectious virus along the optic nerve into the retina in Borna disease virus-infected rabbits Borna disease virus-induced meningoencephalomyelitis caused by a virus-specific CD4+ T cell-mediated immune reaction Escape from lethal disease in rats after Borna disease virus infection: survival with obesity syndrome Influence of immunosuppressive treatment on Borna disease in rabbits Borna disease, a progressive meningoencephalomyelitis as a model for CD4 + T cell-mediated immunopathology in the brain Viral particles induce la antigen expression on astrocytes Tumor necrosis factor amplifies measles virus-mediated la induction on astrocytes Narayan 0, Oldstone MBA. keywords: animals; antibodies; bdv; borna; brain; cells; cns; disease; infection; inoculation; rats; virus cache: cord-007170-svsfu7fj.txt plain text: cord-007170-svsfu7fj.txt item: #12 of 235 id: cord-007296-q9rn75qb author: Muether, Philipp S. title: Variant Effect of First- and Second-Generation Antihistamines as Clues to Their Mechanism of Action on the Sneeze Reflex in the Common Cold date: 2001-11-01 words: 2989 flesch: 43 summary: Churchill Livingstone Physiologic responses to intranasal dose-response challenges with histamine, methacholine, bradykinin, and prostaglandin in adult volunteers with and without nasal allergy Efficacy of brompheniramine maleate treatment for rhinovirus colds Randomized controlled trial of clemastine fumarate for treatment of experimental rhinovirus colds Effectiveness of clemastine fumarate for treatment of rhinorrhea and sneezing associated with the common cold Histamine in nasal secretions Is histamine responsible for the symptoms of rhinovirus colds: a look at the inflammatory mediators following infection Analysis of nasal secretions during experimental rhinovirus upper respiratory infections Histamine in nasal secretions and serum may be elevated during viral respiratory tract infection Experimental rhinovirus 16 infection potentiates histamine release after antigen bronchoprovocation in allergic subjects Mircovascular exudative hyperresponsiveness in human coronavirus-induced common cold Effect of experimental rhinovirus 39 infection on the nasal response to histamine and cold air challenges in allergic and nonallergic subjects Viral infections and allergic disease Goodman & Gilman's the pharmacological basis of therapeutics Ineffectiveness of oral terfenadine in natural colds: evidence against histamine as a mediator of common cold symptoms Evaluation of oral terfenadine for treatment of the common cold Efficacy of terfenadine in the treatment of common cold: a double-blind comparison with placebo The antihistamines of the nineties This article reports a clinical trial using a second-generation antihistamine, loratadine, in adults with experimental rhinovirus colds and reviews the possible sites of action of first-generation and second-generation antihistamines. keywords: antihistamines; colds; generation; generation antihistamines; nasal; sneeze; sneezing cache: cord-007296-q9rn75qb.txt plain text: cord-007296-q9rn75qb.txt item: #13 of 235 id: cord-007321-7gi6xrci author: Chow, Anthony W. title: Evaluation of New Anti-Infective Drugs for the Treatment of Respiratory Tract Infections date: 1992-11-17 words: 16092 flesch: 29 summary: In phase 2 and 3 trials, study patients should be stratified according to major host factors (e.g., history and duration of smoking). Clinical studies should include patients of different age groups, since the clinical manifestations of group A streptococcal pharyngitis and tonsillitis may vary with age of the patient. keywords: acute; aom; children; chronic; control; culture; days; diagnosis; drug; evaluation; failure; group; infection; microbiologic; pathogens; patients; pharyngitis; pneumonia; response; sinusitis; sputum; studies; study; symptoms; therapy; treatment cache: cord-007321-7gi6xrci.txt plain text: cord-007321-7gi6xrci.txt item: #14 of 235 id: cord-007325-g8ke9rfg author: Koskiniemi, Marjaleena title: CNS Manifestations Associated with Mycoplasma pneumoniae Infections: Summary of Cases at the University of Helsinki and Review date: 1993-08-17 words: 2326 flesch: 27 summary: Central nervous system complications of primary atypical pneumonia Mycoplasma pneumoniae infection in the United Kingdom: 1967-1973 Mycoplasmas as agents of human disease Respiratory infections due to Mycoplasma pneumoniae in infants and children Central nervous system disease associated with Mycoplasma pneumoniae infection: report of five cases and review of the literature Central nervous system manifestations associated with serologically verified Mycoplasma pneumoniae infection Studies on Mycoplasma pneumoniae infection in Sweden Aseptic meningitis and meningoencephalitis in cold agglutinin positive infections Mycoplasma pneumoniae meningoencephalitis The clinical spectrum of Mycoplasma pneumoniae infections Jessen 0. Mycoplasma pneumonia presenting as meningoencephalitis and hemolytic anemia Neurological manifestations and Mycoplasma pneumoniae infection Neurological aspects of mycoplasmal infection Encephalitis lethargica-like illness in a girl with mycoplasma infection A brainstem syndrome associated with Mycoplasma pneumoniae infection-a report of two cases Persistent cerebellar symptoms after infection with Mycoplasma pneumoniae Cerebellar syndrome with hydrocephalus due to Mycoplasma pneumoniae infection Recurrent pneumonia and encephalitis due to Mycoplasma pneumoniae Central nervous system complications of Mycoplasma pneumoniae infection Transverse myelitis complicating Mycoplasma pneumoniae infection Mycoplasma pneumoniae meningoencephalitis and transverse myelitis in association with low cerebrospinal fluid glucose Poliomyelitis-like syndrome caused by Mycoplasma pneumoniae Mycoplasma pneumoniae infection in families Psychosis complicating Mycoplasma pneumoniae infection Stroke in a young adult with Mycoplasma pneumoniae infection complicated by intravascular coagulation Cerebral infarction associated with Mycoplasma pneumoniae Neurological complications of primary atypical pneumonia Mycoplasma pneumoniae as a determinant of the Guillain-Barre syndrome Mycoplasma antibody in Guillain-Barre syndrome and other neurological disorders Cranial neuropathy, myeloradiculopathy, and myositis: complications of Mycoplasma pneumoniae infection Cold agglutinins accompanying Mycoplasma pneumoniae infection Mycoplasma pneumoniae infections in children Serological diagnosis of Mycoplasma pneumoniae infection by enzyme immunoassay Antibodies to brain and other tissues in cases of Mycoplasma pneumoniae infection Immunoglobulin M antibody response against Mycoplasma pneumoniae lipid antigen in patients with acute pancreatitis Increase in titers of antibodies to Mycoplasma pneumoniae in patients with purulent meningitis keywords: cases; infection; mycoplasma; patients; pneumoniae cache: cord-007325-g8ke9rfg.txt plain text: cord-007325-g8ke9rfg.txt item: #15 of 235 id: cord-010570-ytv7dwr0 author: Casadevall, Arturo title: Return to the Past: The Case for Antibody-Based Therapies in Infectious Diseases date: 1995-07-17 words: 7474 flesch: 27 summary: Chemotherapy was more effective and less toxic than antibody therapy. Serum therapy reduced mortality in diphtheria, and antibody therapy continues to be used today to treat this disease keywords: antibodies; antibody; chemotherapy; human; immune; infections; intravenous; mabs; monoclonal; murine; pathogens; patients; serum; therapies; therapy; treatment; use cache: cord-010570-ytv7dwr0.txt plain text: cord-010570-ytv7dwr0.txt item: #16 of 235 id: cord-010578-uib9h1lb author: Mawle, Alison C. title: Seroepidemiology of Chronic Fatigue Syndrome: A Case-Control Study date: 1995-12-17 words: 2573 flesch: 45 summary: Reports that viral antibody titers are elevated in CFS cases has led to the speculation that latent viruses may be reactivated in this illness as a result of an underlying perturbation of immune function, and that elevated titers of antibody to common agents may be a reflection of this disturbance. Epstein-Barr virus (EBV) early antigen antibody titers were determined with a commercial ELISA (Gull Laboratories, Salt Lake City), and a titer of~I: 10 was considered positive. keywords: agents; antibodies; antibody; cases; cfs; controls; infection; patients; virus cache: cord-010578-uib9h1lb.txt plain text: cord-010578-uib9h1lb.txt item: #17 of 235 id: cord-010599-nwp2if8d author: Hayden, Frederick G. title: Efficacy and Safety of Oral Pleconaril for Treatment of Colds Due to Picornaviruses in Adults: Results of 2 Double-Blind, Randomized, Placebo-Controlled Trials date: 2003-06-15 words: 3997 flesch: 40 summary: Participants were evaluated at enrollment and again on study days 3, 6 (end of treatment), and 18 (end of the study) for clinical assessment and obtainment of samples for laboratory testing. Safety laboratory studies (hematological study, clinical chemistry, and urinalysis) and physical assessments were done at enrollment and on study day 6. Virology assessments. keywords: baseline; cold; day; placebo; pleconaril; recipients; study; subjects; symptom; treatment cache: cord-010599-nwp2if8d.txt plain text: cord-010599-nwp2if8d.txt item: #18 of 235 id: cord-011745-dbdtpojs author: Thompson, Mark G. title: Effectiveness of Nonadjuvanted Monovalent Influenza A(H1N1)pdm09 Vaccines for Preventing Reverse Transcription Polymerase Chain Reaction–Confirmed Pandemic Influenza Hospitalizations: Case-Control Study of Children and Adults at 10 US Influenza Surveillance Network Sites date: 2013-12-01 words: 2608 flesch: 33 summary: Compared with community controls, hospitalized influenza cases were more likely to be non-white, Hispanic, and unmarried; have less education and lower incomes; lack private healthcare insurance; be obese; and have high-risk medical conditions (Table 1) . key: cord-011745-dbdtpojs authors: Thompson, Mark G.; Sokolow, Leslie Z.; Almendares, Olivia; Openo, Kyle; Farley, Monica M.; Meek, James; Ray, Julie; Kirley, Pamala Daily; Reingold, Arthur; Aragon, Deborah; Hancock, Emily; Baumbach, Joan; Schaffner, William; Lynfield, Ruth; Ryan, Pat; Monroe, Maya; Cheng, Po-Yung; Fry, Alicia M.; Shay, David K. title: Effectiveness of Nonadjuvanted Monovalent Influenza A(H1N1)pdm09 Vaccines for Preventing Reverse Transcription Polymerase Chain Reaction–Confirmed Pandemic Influenza Hospitalizations: Case-Control Study of Children and Adults at 10 US Influenza Surveillance Network Sites date: 2013-12-01 journal: Clin Infect Dis DOI: 10.1093/cid/cit551 sha: doc_id: 11745 cord_uid: dbdtpojs During 2009–2010, we examined 217 patients hospitalized with laboratory-confirmed pandemic influenza in 9 Influenza Hospitalization Surveillance Network sites and 413 age- and community-matched controls and found that a single dose of monovalent nonadjuvanted influenza A(H1N1)pdm09 vaccine was 50% (95% confidence interval, 13%–71%) effective in preventing hospitalization associated with A(H1N1)pdm09 virus infection. keywords: cases; controls; influenza; pandemic; vaccine; years cache: cord-011745-dbdtpojs.txt plain text: cord-011745-dbdtpojs.txt item: #19 of 235 id: cord-012511-fl5llkoj author: Meltzer, Martin I. title: Standardizing Scenarios to Assess the Need to Respond to an Influenza Pandemic date: 2015-05-01 words: 4144 flesch: 51 summary: A descriptive brochure National influenza experience in the The economic impact of pandemic influenza in the United States: priorities for intervention For example, to construct the matrix element pertaining to the total number of contacts between the 0-9-year age group and the 0-9-year age group (ie, itself ), we perform the following sum:3 914 000 Ã 2:6 þ 3 517 000 Ã 7:6 ¼ 36 905 600: This is the first diagonal element of the total contacts matrix and, again, it represents the total number of contacts made per day between those in the 0-9-year age group. The clinical attack rates by age group are presented in Table 3 . keywords: age; data; group; influenza; matrix; number; pandemic cache: cord-012511-fl5llkoj.txt plain text: cord-012511-fl5llkoj.txt item: #20 of 235 id: cord-015493-vf4et613 author: Deresinski, Stan title: In the Literature date: 2007-10-15 words: 1568 flesch: 41 summary: The authors point out that these data support current recommendations for screening sexually active females aged р25 years for chlamydial infection and for coadministration of treatment for C. trachomatis infection in patients with gonorrheal infection, unless the former has been ruled out Chlamydia trachomatis finds a way to evade diagnosis Screening for chlamydial infection: US Preventive Services Task Force Recommendation Statement The most frequently reported notifiable disease in the United States is infection with Chlamydia trachomatis, with Neisseria gonorrhoeae infection placing second. keywords: antibiotic; infection; patients cache: cord-015493-vf4et613.txt plain text: cord-015493-vf4et613.txt item: #21 of 235 id: cord-015516-hx7ktq8j author: None title: In the Literature date: 2005-10-15 words: 1500 flesch: 42 summary: Heterologous expression of S. aureus carotenoids in Streptococcus pyogenes conferred relative resistance to oxidants and killing by neutrophils, as well as increased virulence in an animal model of infection. The golden pigment produced by S. aureus is compromised of a group of carotenoids. keywords: angiotensin; patients; sars cache: cord-015516-hx7ktq8j.txt plain text: cord-015516-hx7ktq8j.txt item: #22 of 235 id: cord-032234-pfr4l1v9 author: Poloni, Chad title: Evaluating Immune Dysregulation in Patients With COVID-19 Requires a More Accurate Definition of the CD45RA(+) T-cell Phenotype date: 2020-06-04 words: 680 flesch: 35 summary: Dysregulation of immune response in patients with COVID-19 in Wuhan, China T cell aging: a review of the transcriptional changes determined from genome-wide analysis Immunosupportive therapies in aging Cytomegalovirus infection and relative risk of cardiovascular disease (ischemic heart disease, stroke, and cardiovascular death): a meta-analysis of prospective studies up to Cytomegalovirus infection and risk of Alzheimer disease in older black and white individuals Comprehensive evaluation of the immune risk phenotype in successfully treated HIV-infected individuals T cell responses to cytomegalovirus From truly naïve to exhausted senescent T cells: when markers predict functionality Multiparameter flow cytometric analysis of CD4 and CD8 T cell subsets in young and old people Although naive T cells are characterized by the presence of a combination of surface markers including CD45RA, this marker alone cannot be used to define naive subsets. keywords: cell cache: cord-032234-pfr4l1v9.txt plain text: cord-032234-pfr4l1v9.txt item: #23 of 235 id: cord-251945-v077hhgk author: Titanji, Boghuma K title: Response to Correspondence: Baricitinib as Treatment of COVID-19 Friend or Foe of the Pancreas? Cerda-Contreras et.al date: 2020-08-14 words: 730 flesch: 27 summary: A c c e p t e d M a n u s c r i p t COVID-19 presenting as acute pancreatitis Coronavirus Disease-19 (COVID-19) associated with severe acute pancreatitis: Case report on three family members New-Onset Diabetes in Covid-19 Acute pancreatitis associated with intravenous administration of propofol: evaluation of causality in a systematic review of the literature Acute Pancreatitis Associated with Steroid Therapy Acute necrotising pancreatitis derived from lowdose corticosteroid use: an important reminder of clinical management Obesity is a definitive risk factor of severity and mortality in acute pancreatitis: An updated meta-analysis FRI0123 Safety profile of baricitinib for the treatment of rheumatoid arthritis up to 8.4 years: an updated integrated safety analysis COVID-19: combining antiviral and antiinflammatory treatments Glucocorticosteroids enhance replication of respiratory viruses: effect of adjuvant interferon Contrary to what is stated in their correspondence, acute pancreatitis has been described in several case reports as a manifestation of COVID-19 1,2 . keywords: covid-19; pancreatitis cache: cord-251945-v077hhgk.txt plain text: cord-251945-v077hhgk.txt item: #24 of 235 id: cord-252005-3ld5e7f5 author: Lewis, Nathaniel M title: Household Transmission of SARS-CoV-2 in the United States date: 2020-08-16 words: 3046 flesch: 47 summary: People with COVID-19, particularly those with immunocompromising conditions or those with household contacts with diabetes, should take care to promptly self-isolate to prevent household transmission. First, we assumed that household transmission was responsible for infections among household contacts. keywords: contacts; cov-2; covid-19; household; infection; patients; sars; transmission cache: cord-252005-3ld5e7f5.txt plain text: cord-252005-3ld5e7f5.txt item: #25 of 235 id: cord-252423-ojmt4k2w author: Qu, Bing title: Monologue of a physician who tested persistently positive for COVID-19 date: 2020-05-11 words: 1102 flesch: 67 summary: 1 Similar to other COVID-19 patients, I had dry cough, fever, body aches, and fatigue during the first week. This new group of patients have brought new challenge to COVID-19 treatment. keywords: covid-19 cache: cord-252423-ojmt4k2w.txt plain text: cord-252423-ojmt4k2w.txt item: #26 of 235 id: cord-252761-ro5tj0tx author: Marriott, Deborah title: Concomitant marked decline in prevalence of SARS-CoV-2 and other respiratory viruses among symptomatic patients following public health interventions in Australia: data from St Vincent’s Hospital and associated screening clinics, Sydney, NSW. date: 2020-08-25 words: 1232 flesch: 50 summary: Despite the broadening of testing criteria, an increase in total testing numbers, and a move into cooler months, SARS- CoV-2 cases to similarly rise supports the absence of circulating SARS CoV-2 in the NSW community during that period, but the increased rhinovirus transmission does raise concern that SARS CoV-2 may also spread readily if reintroduced. key: cord-252761-ro5tj0tx authors: Marriott, Deborah; Beresford, Rohan; Mirdad, Feras; Stark, Damien; Glanville, Allan; Chapman, Scott; Harkness, Jock; Dore, Gregory J; Andresen, David; Matthews, Gail V title: Concomitant marked decline in prevalence of SARS-CoV-2 and other respiratory viruses among symptomatic patients following public health interventions in Australia: data from St Vincent’s Hospital and associated screening clinics, Sydney, NSW. date: 2020-08-25 journal: Clin Infect Dis DOI: 10.1093/cid/ciaa1256 sha: doc_id: 252761 cord_uid: ro5tj0tx Our Australian hospital tested almost 22,000 symptomatic people over 11 weeks for SARS-CoV-2 in a multiplex PCR assay. keywords: cov-2; sars cache: cord-252761-ro5tj0tx.txt plain text: cord-252761-ro5tj0tx.txt item: #27 of 235 id: cord-254183-98o0dssj author: Waggoner, Jesse J. title: Rare and Emerging Viral Infections in Transplant Recipients date: 2013-10-15 words: 3937 flesch: 41 summary: While often first identified in the general population, they may affect transplant recipients, in whom their manifestations may be atypical or more severe. Detection and reporting of such rare pathogens in transplant recipients is critical to patient care and improving our understanding of posttransplant infections. keywords: cases; htlv-1; infection; patients; recipients; transplant; transplantation; virus; viruses cache: cord-254183-98o0dssj.txt plain text: cord-254183-98o0dssj.txt item: #28 of 235 id: cord-254458-bbcef8xt author: Ali, Farhana title: Throat Wash Testing and COVID-19 Disease: Should We Put Our Money Where Our Mouth Is? date: 2020-04-30 words: 1110 flesch: 48 summary: Admittedly, the sensitivity of throat wash testing almost seems too good to be true; nonetheless, the ramifications of failing to identify COVID-19 positive patients would have dire consequences amid a pandemic. Similarly, there have also been shortages of nasopharyngeal swabs, leading to delays in COVID-19 testing [7] . keywords: covid-19; testing cache: cord-254458-bbcef8xt.txt plain text: cord-254458-bbcef8xt.txt item: #29 of 235 id: cord-256583-z3pd339v author: Yen, Muh-Yong title: Traffic Control Bundling Is Essential for Protecting Healthcare Workers and Controlling the 2014 Ebola Epidemic date: 2015-03-01 words: 1077 flesch: 41 summary: Ebola and compliance with infection prevention measures in Nigeria Guidance on personal protective equipment to be used by healthcare workers during management of patients with Ebola virus disease in U.S. hospitals, including procedures for putting on (donning) and removing (doffing) Sierra Leone's top Ebola doctor gets virus NYC doctor Craig Spencer followed proper protocol after returning from Ebolastricken West Africa US doctor with Ebola lands in Nebraska for treatment Persistence in darkness of virulent alphaviruses, Ebola virus, and Lassa virus deposited on solid surfaces Assessment of the risk of Ebola virus transmission from bodily fluids and fomites Using an integrated infection control strategy during outbreak control to minimize nosocomial infection of severe acute respiratory syndrome among healthcare workers Taiwan's traffic control bundle and the elimination of nosocomial severe acute respiratory syndrome among health care workers From SARS in 2003 to H1N1 in 2009: Indeed, infection struck even among HCWs caring for patients with Ebola virus disease (EVD) in Western hospitals equipped with modern facilities and procedures. keywords: ebola; hcws; zones cache: cord-256583-z3pd339v.txt plain text: cord-256583-z3pd339v.txt item: #30 of 235 id: cord-257553-479x7av6 author: Kortepeter, Mark G. title: Health Care Workers and Researchers Traveling to Developing-World Clinical Settings: Disease Transmission Risk and Mitigation date: 2010-12-01 words: 3971 flesch: 36 summary: Most HCWs are not counseled regarding tuberculosis risks before departure, nor are they evaluated on their return. There are conflicting opinions regarding the importance of airborne transmission of influenza viruses in humans keywords: exposure; health; hiv; infection; influenza; risk; transmission; treatment; tuberculosis; virus; viruses cache: cord-257553-479x7av6.txt plain text: cord-257553-479x7av6.txt item: #31 of 235 id: cord-258304-86gqxajw author: Bahl, Prateek title: Droplets and Aerosols generated by singing and the risk of COVID-19 for choirs date: 2020-09-18 words: 1554 flesch: 49 summary: To capture the video, the head of the subject was adjusted in front of black backdrop/background and the light was positioned in a forward scatter arrangement to maximize the scattering from expelled droplets ( Figure 1 ). While social distancing is effective in normal social interactions, singing can produce a substantially larger number of respiratory droplets and aerosols than speaking, as it is louder and sustained for longer durations keywords: covid-19; droplets; singing; velocities cache: cord-258304-86gqxajw.txt plain text: cord-258304-86gqxajw.txt item: #32 of 235 id: cord-258724-1qhen1bj author: Young, Barnaby E title: Viral dynamics and immune correlates of COVID-19 disease severity date: 2020-08-28 words: 3616 flesch: 43 summary: Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China Interventions to mitigate early spread of SARS-CoV-2 in Singapore: a modelling study Clinical and immunological features of severe and moderate coronavirus disease 2019 Dysregulation of Immune Response in Patients With Coronavirus Longitudinal analyses reveal immunological misfiring in severe COVID-19 Longitudinal COVID-19 profiling associates IL-1RA and IL-10 with disease severity and RANTES with mild disease Antibody responses to SARS-CoV-2 in patients of novel coronavirus disease Virological assessment of hospitalized patients with COVID-2019 Severe Acute Respiratory Syndrome Coronavirus 2-Specific Antibody Responses in Coronavirus Disease Patients Temporal profiles of viral load in posterior oropharyngeal saliva samples and serum antibody responses during infection by SARS-CoV-2: an observational cohort study Kinetics of SARS-CoV-2 specific IgM and IgG responses in COVID-19 patients Neutralizing Antibody Responses to Severe Acute Respiratory Syndrome Coronavirus 2 in Coronavirus Disease 2019 Inpatients and Convalescent Patients Impact of immune enhancement on Covid-19 polyclonal hyperimmune globulin therapy and vaccine development Viral load dynamics and disease severity in patients infected with SARS-CoV-2 in Zhejiang province, China Shedding of infectious virus in hospitalized patients with coronavirus disease-2019 (COVID-19): duration and key determinants SARS-CoV-2 Virus Culture and Subgenomic RNA for Respiratory Specimens from Patients with Mild Coronavirus Disease Temporal dynamics in viral shedding and transmissibility of COVID-19 Epidemiologic Features and Clinical Course of Patients Infected With SARS-CoV-2 in Singapore COVID-19 CRF -ISARIC. Studies of COVID-19 patients have described the inflammatory milieu in severe infections, with raised neutrophils, suppressed lymphocytes and elevated inflammatory mediators [3, 4] . keywords: c r; covid-19; disease; patients; pcr; sars; severity; study cache: cord-258724-1qhen1bj.txt plain text: cord-258724-1qhen1bj.txt item: #33 of 235 id: cord-259243-1lkzcslx author: Álvarez-Aragón, Luis Miguel title: Inquiring into Benefits of Independent Activation of Non-Classical Renin-Angiotensin System in the Clinical Prognosis and Reduction of COVID-19 mortality date: 2020-04-08 words: 757 flesch: 36 summary: It is pertinent to evoke that ACE2 is also a fundamental component in the ACE2-Angiotensin(1-7)-MasR axis, also known as non-classical RAS, indicating, therefore, the existence of non-classical RAS also in the lungs. Non-classical RAS is a counter-regulatory system of the classical RAS in that its end product, Angiotensin(1-7), which after binding to the Mas receptor, presents important antiinflammatory, anti-proliferative, anti-fibrotic, natriuretic and vasodilator effects [5] , actions completely opposed to those promoted by the end product of the classical RAS Angiotensin II. keywords: classical; ras cache: cord-259243-1lkzcslx.txt plain text: cord-259243-1lkzcslx.txt item: #34 of 235 id: cord-259471-lsdodl0a author: Pagliano, Pasquale title: Is Hydroxychloroquine a Possible Postexposure Prophylaxis Drug to Limit the Transmission to Healthcare Workers Exposed to Coronavirus Disease 2019? date: 2020-03-24 words: 631 flesch: 19 summary: Repurposing of the anti-malaria drug chloroquine for Zika virus treatment and prophylaxis Chloroquine is a potent inhibitor of SARS coronavirus infection and spread Clinical trial analysis of 2019-nCoV therapy registered in China Chloroquine and hydroxychloroquine are able to inhibit replication at early stages of viral infection, increasing endosomal pH at the time of virus/cell fusion, as well as impairing the glycosylation of cellular receptors of many viruses including coronavirus [3] . keywords: cov-2; hydroxychloroquine; sars cache: cord-259471-lsdodl0a.txt plain text: cord-259471-lsdodl0a.txt item: #35 of 235 id: cord-260274-c3586tp6 author: Somers, Emily C title: Tocilizumab for treatment of mechanically ventilated patients with COVID-19 date: 2020-07-11 words: 3655 flesch: 30 summary: Untreated patients who died prior to the opportunity to receive tocilizumab treatment per institutional criteria (within 48 hours of intubation) were excluded to minimize immortal time bias. To address non-randomized treatment allocation, we calculated propensity scores by multivariable logistic regression with tocilizumab treatment as the binary outcome and potential confounding factors associated with both outcome and treatment assignment. keywords: covid-19; il-6; patients; pneumonia; respiratory; study; superinfection; tocilizumab; treatment; ventilation cache: cord-260274-c3586tp6.txt plain text: cord-260274-c3586tp6.txt item: #36 of 235 id: cord-260457-m1jbpo5l author: Allander, Tobias title: Human Bocavirus and Acute Wheezing in Children date: 2007-04-01 words: 3715 flesch: 46 summary: As part of a randomized, placebo-controlled clinical trial evaluating the efficacy of systemic corticosteroids for the treatment of acute expiratory wheezing in children, we performed extensive diagnostic evaluations for respiratory virus infection. We investigated the prevalence of HBoV and the genome HBoV load in the respiratory tract and blood specimens obtained from children who had been hospitalized for acute expiratory wheezing-the most common manifestation of lower respiratory tract infection in children-to investigate the association between HBoV infection and acute respiratory tract illness. keywords: acute; children; hbov; infection; samples; serum; virus; wheezing cache: cord-260457-m1jbpo5l.txt plain text: cord-260457-m1jbpo5l.txt item: #37 of 235 id: cord-260630-vvpzp73r author: Mandell, Lionel A. title: Etiologies of Acute Respiratory Tract Infections date: 2005-08-15 words: 2627 flesch: 48 summary: A case-control study of acute respiratory tract infection in general practice patients in The Netherlands Human metapneumovirus infection in adults with community-acquired pneumonia and exacerbation of chronic obstructive pulmonary disease Epidemiology of viral respiratory infections Coronavirus as a possible cause of severe acute respiratory syndrome A novel coronavirus associated with severe acute respiratory syndrome Virologic studies of acute respiratory disease in young adults. key: cord-260630-vvpzp73r authors: Mandell, Lionel A. title: Etiologies of Acute Respiratory Tract Infections date: 2005-08-15 journal: Clin Infect Dis DOI: 10.1086/432019 sha: doc_id: 260630 cord_uid: vvpzp73r nan In this issue of Clinical Infectious Diseases, there are 2 articles that provide us with some insight into the various etiologic agents that can cause acute respiratory tract infection (ARTI) in general practice patients in The Netherlands [1] and into the significance of the human metapneumovirus (hMPV) in patients with community-acquired pneumonia (CAP) and exacerbations of chronic obstructive pulmonary disease (COPD) in Quebec, Canada keywords: hmpv; infection; pathogens; patients; study; subjects cache: cord-260630-vvpzp73r.txt plain text: cord-260630-vvpzp73r.txt item: #38 of 235 id: cord-260779-riw5xs3j author: van Griensven, Johan title: The Use of Ebola Convalescent Plasma to Treat Ebola Virus Disease in Resource-Constrained Settings: A Perspective From the Field date: 2016-01-01 words: 3826 flesch: 43 summary: Compassionate use of experimental treatments for Ebola virus disease: outcomes in 14 patients admitted from Ebola virus convalescent blood products: where we are now and where we may need to go Minipool caprylic acid fractionation of plasma using disposable equipment: a practical method to enhance immunoglobulin supply in developing countries Emergency evaluation of convalescent plasma for Ebola viral disease (EVD) in Guinea Clinical trial to evaluate the efficacy and safety of convalescent plasma for Ebola treatment (EVD001). Longer followup of CP treated patients is also indicated to detect late adverse events. keywords: blood; convalescent; ebola; evd; patients; plasma; transfusion; treatment cache: cord-260779-riw5xs3j.txt plain text: cord-260779-riw5xs3j.txt item: #39 of 235 id: cord-261270-jkm9c5yv author: Annweiler, Cédric title: National French survey of COVID-19 symptoms in people aged 70 and over date: 2020-06-18 words: 1710 flesch: 47 summary: Symptoms of COVID-19 among older adults: systematic review of biomedical literature Coronavirus Disease 2019 in elderly patients: characteristics and prognostic factors based on 4-week follow-up Clinical characteristics and outcomes of older patients with coronavirus disease 2019 (COVID-19) in Wuhan, China (2019): a single-centered, retrospective study Novel Coronavirus Infection (COVID-19) in Humans: A Scoping Review and Meta-Analysis Prevalence of comorbidities in the novel Wuhan coronavirus (COVID-19) infection: a systematic review and meta-analysis Clinical characteristics of hospitalized patients with SARS-CoV-2 infection: A single arm meta-analysis Epidemiological, clinical and virological characteristics of 74 cases of coronavirus-infected disease 2019 (COVID-19) with gastrointestinal symptoms Leukocytes°/°mm 3 (n=17), mean ± SD 2 394 ± 881 2613±1174 COPD: chronic obstructive pulmonary disease; ENT: ear nose and throat; GIR: iso resource group; N: total number of patient included in the study; n: number of patients according to the considered group; SD: standard deviation; y: years; Compared to previous meta-analyses in younger adults [5] [6] [7] , we found that older adults with COVID-19 often exhibit thermal dysregulation, which however results less often in hyperthermia (56% here versus 82% keywords: adults; covid-19 cache: cord-261270-jkm9c5yv.txt plain text: cord-261270-jkm9c5yv.txt item: #40 of 235 id: cord-264660-tfktgy57 author: Creech, C Buddy title: It’s True Even in a Pandemic: Children are Not Merely Little Adults date: 2020-05-30 words: 981 flesch: 43 summary: They share a predilection for severe disease, particularly in high risk hosts, while they also benefit from asymptomatic hosts and minimally symptomatic individuals who are capable of transmission prior to obvious signs of disease. Moreover, we must recognize that some proportion of children that are infected will experience either moderate disease, severe disease, or immunologically mediated complications, such as MIS-C. Defining the true burden of disease across pediatrics will be essential as we consider best practices for the start of the 2020-21 academic year. keywords: adults; children; disease cache: cord-264660-tfktgy57.txt plain text: cord-264660-tfktgy57.txt item: #41 of 235 id: cord-265006-m1dmgcd1 author: Kow, Chia Siang title: Do the meta-analyses provide a clean bill of health to the use of renin-angiotensin system inhibitors in COVID-19? date: 2020-08-08 words: 843 flesch: 30 summary: Patients with these conditions too need long-term usage of RAS inhibitors, where increased expression of ACE2 receptor, which is the hypothesized pathological A c c e p t e d M a n u s c r i p t mechanism leading to worse outcomes among COVID-19 patients receiving RAS inhibitors, could also occur in the users of RAS inhibitors for indications other than hypertension Secondly, some of these systematic reviews and meta-analyses included studies or only involved findings on COVID-19 patients with concurrent hypertension. keywords: covid-19; inhibitors cache: cord-265006-m1dmgcd1.txt plain text: cord-265006-m1dmgcd1.txt item: #42 of 235 id: cord-265242-y8t37p0b author: Cui, Wei title: Expression of Lymphocytes and Lymphocyte Subsets in Patients with Severe Acute Respiratory Syndrome date: 2003-09-15 words: 1785 flesch: 59 summary: Among the T cell subsets, CD4 + T cell counts were found to have decreased in all patients; the lowest value was cells/L. Therefore, CD8 + T cell counts should be sharply increased in patients with SARS. keywords: cells; count; lymphocyte; patients; sars cache: cord-265242-y8t37p0b.txt plain text: cord-265242-y8t37p0b.txt item: #43 of 235 id: cord-266150-wox7pnkr author: Torres, Juan Pablo title: SARS-CoV-2 antibody prevalence in blood in a large school community subject to a Covid-19 outbreak: a cross-sectional study date: 2020-07-10 words: 4206 flesch: 46 summary: The median percent of antibody positive students per classroom was 8.3% (IQR 1.6-14.3%). Certainly, school related outbreak studies from other settings and situations, especially after the first wave, are required to further increase our knowledge of transmission dynamics within M a n u s c r i p t 10 schools, in order to pinpoint recommendations which may end up being most effective. keywords: antibody; cases; children; covid-19; outbreak; positivity; school; staff; students; test cache: cord-266150-wox7pnkr.txt plain text: cord-266150-wox7pnkr.txt item: #44 of 235 id: cord-266696-w9sb038q author: Zhou, Yi-Hua title: Is the Immune System Impaired in Patients with Severe Acute Respiratory Syndrome? date: 2004-03-15 words: 1307 flesch: 49 summary: [1] suggested that SARS coronavirus (SARS-CoV) might damage lymphocytes and concluded that the immune system was impaired during the course of SARS. [1] recently described pronounced lymphopenia and low counts of CD4 + cells, CD8 + cells, and B cells in patients with severe acute respiratory syndrome (SARS). keywords: patients; sars; syndrome cache: cord-266696-w9sb038q.txt plain text: cord-266696-w9sb038q.txt item: #45 of 235 id: cord-266775-4npowkkz author: Xu, Jun title: Detection of Severe Acute Respiratory Syndrome Coronavirus in the Brain: Potential Role of the Chemokine Mig in Pathogenesis date: 2005-10-15 words: 3454 flesch: 42 summary: This study provides direct evidence that SARS human coronavirus is capable of infecting the central nervous system, and that Mig might be involved in the brain immunopathology of SARS. [5] reported that a CSF sample obtained from a 32-year-old woman with SARS tested positive for SARS coronavirus (SARS-CoV) by RT-PCR, indicating that SARS-CoV might cause an infection in the CNS of patients with SARS. keywords: brain; coronavirus; cov; infection; mig; patient; protein; sars; tissue cache: cord-266775-4npowkkz.txt plain text: cord-266775-4npowkkz.txt item: #46 of 235 id: cord-266808-wyuodzyt author: Nagler, Arielle R title: Early Results from SARS-CoV-2 PCR testing of Healthcare Workers at an Academic Medical Center in New York City date: 2020-06-28 words: 1595 flesch: 47 summary: Employee testing is critical for workforce planning since COVID-19 positive employees require home-isolation for 10 days. [3] Although specifically designed for symptomatic testing, RT-PCR can be used to detect COVID-19 infection in both symptomatic and asymptomatic individuals. keywords: testing cache: cord-266808-wyuodzyt.txt plain text: cord-266808-wyuodzyt.txt item: #47 of 235 id: cord-266820-exl36jt3 author: Rivera, Frida title: Prevalence of SARS-CoV-2 asymptomatic infections in two large academic health systems in Wisconsin date: 2020-08-19 words: 876 flesch: 50 summary: [2] Some studies suggest that asymptomatic infections could be responsible for amplifying the spread of the disease. [3] However, data regarding the prevalence of asymptomatic infections and their impact on transmission are still scarce. keywords: asymptomatic; cov-2 cache: cord-266820-exl36jt3.txt plain text: cord-266820-exl36jt3.txt item: #48 of 235 id: cord-267152-m9m0aunk author: Yang, Philip title: Investigating the sex differences in COVID-19: Another step forward, but many unanswered questions date: 2020-06-28 words: 1413 flesch: 48 summary: It is too early to determine whether sex differences identified in this study would have practical implications for management, especially because the numerous potential reasons for such differences still need to be further elucidated. These findings may be one of the potential reasons for the predominance of male patients (82%) in the Italian cohort of COVID-19 patients admitted to A keywords: covid-19; differences; patients cache: cord-267152-m9m0aunk.txt plain text: cord-267152-m9m0aunk.txt item: #49 of 235 id: cord-268809-plgip4h6 author: Bielecki, Michel title: Social distancing alters the clinical course of COVID-19 in young adults: A comparative cohort study date: 2020-06-29 words: 2610 flesch: 46 summary: A prospective contact-tracing study Exploration of the effectiveness of social distancing on respiratory pathogen transmission implicates environmental contributions Simulation suggests that rapid activation of social distancing can arrest epidemic development due to a novel strain of influenza Risk factors for SARS infection among hospital healthcare workers in Beijing: a case control study Handwashing and respiratory illness among young adults in military training1 1The full text of this article is available via AJPM Online at www.elsevier.com/locate/ajpmonline Physical interventions to interrupt or reduce the spread of respiratory viruses Assessing the airborne survival of bacteria in populations of aerosol droplets with a novel technology A new transmission route for the propagation of the SARS-CoV-2 coronavirus A familial cluster of pneumonia associated with the 2019 novel coronavirus indicating person-to-person transmission: a study of a family cluster Surface Environmental, and Personal Protective Equipment Contamination by Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) From a Symptomatic Patient Initial viral load and the outcomes of SARS Short term outcome and risk factors for adverse clinical outcomes in adults with severe acute respiratory syndrome (SARS) The Incubation Period of Coronavirus Disease 2019 (COVID-19) From Publicly Reported Confirmed Cases: Estimation and Application Impact assessment of non-pharmaceutical interventions against coronavirus disease 2019 and influenza in Hong Kong: an observational study The effect of control strategies to reduce social mixing on outcomes of the COVID-19 epidemic in Wuhan, China: a modelling study Temporal dynamics in viral shedding and transmissibility of COVID-19 Follow-up of asymptomatic patients with SARS-CoV-2 infection Estimating the asymptomatic proportion of coronavirus disease 2019 (COVID-19) cases on board the Diamond Princess cruise ship The contribution of asymptomatic SARS-CoV-2 infections to transmission-a model-based analysis of the Diamond Princess outbreak Asymptomatic and Presymptomatic SARS-CoV-2 Infections in Residents of a Long-Term Care Skilled Nursing Facility Asymptomatic cases in a family cluster with SARS-CoV-2 infection Herd immunity -estimating the level required to halt the COVID-19 epidemics in affected countries Repeated seroprevalence of anti-SARS-CoV-2 IgG antibodies in While both groups show evidence of infection, the rate of symptomatic COVID-19 amongst the infected soldiers differed significantly amongst the two groups and was much lower in the cohort where infection happened after the implementation of these measures. keywords: covid-19; p t cache: cord-268809-plgip4h6.txt plain text: cord-268809-plgip4h6.txt item: #50 of 235 id: cord-269455-pkjov371 author: Faust, Jeremy Samuel title: Towards a better case fatality estimate for SARS-CoV-2 during the early phase of the United States outbreak date: 2020-05-30 words: 977 flesch: 52 summary: Using the Kou model as a source for the denominator (cases as of March 21 st ) and all deaths through April 4 th as the numerator (including all deaths that occurred on US soil prior to March 21), the calculated CFR appears to have been approximately 22 percent of estimates on public-facing COVID19 trackers-and this only accounts for symptomatic cases ( Table 1 , column 1). Together, these data imply that a more accurate CFR for SARS-CoV-2 may rest between 0.5 and 0.8 percent for symptomatic cases, and 0.2 and 0.4 percent for all cases including pre-and asymptomatic infections. keywords: covid-19; percent cache: cord-269455-pkjov371.txt plain text: cord-269455-pkjov371.txt item: #51 of 235 id: cord-269973-sntnmqqd author: To, Kelvin Kai-Wang title: Unique SARS-CoV-2 clusters causing a large COVID-19 outbreak in Hong Kong date: 2020-08-05 words: 1862 flesch: 55 summary: All the genomes from cases imported from the Philippines did not contain nsp3 A85V or NP A12G that define cluster HK1, while those from Kazakhstan lack the mutation C28269T that define cluster HK2. However, resurgence of COVID-19 cases has been seen in many parts of the world after the relaxation of these social distancing measures. keywords: cases; cluster; covid-19 cache: cord-269973-sntnmqqd.txt plain text: cord-269973-sntnmqqd.txt item: #52 of 235 id: cord-271014-xzpvupms author: Erikstrup, Christian title: Estimation of SARS-CoV-2 infection fatality rate by real-time antibody screening of blood donors date: 2020-06-25 words: 2369 flesch: 52 summary: The objective was to perform nationwide real-time seroprevalence surveying among blood donors as a tool to estimate previous SARS-CoV-2 infections and the population based IFR. Blood donors comprise approximately 4.7% of the Danish population in the same age group [2]. keywords: blood; cov-2; sars; seroprevalence cache: cord-271014-xzpvupms.txt plain text: cord-271014-xzpvupms.txt item: #53 of 235 id: cord-271269-0gimxteg author: Gourtsoyannis, John title: COVID-19: Possible reasons for the increased prevalence of Olfactory and Gustatory dysfunction observed in European studies date: 2020-05-31 words: 582 flesch: 41 summary: The first possibility is informed by the hypothesis that there are differences in ACE2 receptor expression in the nasopharynx of East Asians as compared to European populations. 9 Increased expression of ACE2 in European populations may contribute to a higher risk of olfactory and gustatory symptoms. keywords: european cache: cord-271269-0gimxteg.txt plain text: cord-271269-0gimxteg.txt item: #54 of 235 id: cord-272956-0yumc7em author: Gnavi, Roberto title: Therapy With Agents Acting on the Renin-Angiotensin System and Risk of Severe Acute Respiratory Syndrome Coronavirus 2 Infection date: 2020-05-22 words: 1772 flesch: 40 summary: The study was conducted using data retrieved from the regional surveillance system of confirmed CVi cases. However, as studies gathering a large population of confirmed cases require time and may be demanding, smaller but more timely studies can contribute to give answers to urgent public health questions. keywords: agents; angiotensin; cases; cvi; patients cache: cord-272956-0yumc7em.txt plain text: cord-272956-0yumc7em.txt item: #55 of 235 id: cord-273839-oasgagpc author: Bisno, Alan L. title: Diagnosis and Management of Group A Streptococcal Pharyngitis: A Practice Guideline date: 1997-09-17 words: 5778 flesch: 37 summary: Sulfonamides and tetracyclines are not recommended for treatment of group group A streptococci from the upper respiratory tract. cultures Comparative effectiveness of three prophylaxis regimens in pre Ann Intern Comparison of throat culture methods for the recovery of group A streptococci in a pediatric office setting In vitro susceptibility of recent North American Diagnosis of pharyngitis: methodology of throat cultures Suitability of throat culture procedures for detection of group streptococcal pharyngitis and prevention of rheumatic fever: a statement A streptococci and as reference standards for evaluation of streptococcal for health professionals. keywords: acute; cultures; group; hemolytic; patients; penicillin; pharyngitis; streptococci; therapy; throat cache: cord-273839-oasgagpc.txt plain text: cord-273839-oasgagpc.txt item: #56 of 235 id: cord-273840-jjm7y07m author: Vabret, Astrid title: Detection of the New Human Coronavirus HKU1: A Report of 6 Cases date: 2006-03-01 words: 3080 flesch: 51 summary: Human coronavirus HKU1 (HCoV-HKU1), a new group 2 coronavirus, was first characterized in 2005 from 2 adults with pneumonia in Hong Kong, China. We are able to detect HKU1 in respiratory samples and stool specimens, indicating that this virus can be excreted in this way. keywords: coronavirus; hcov; hku1; patients; pcr; samples cache: cord-273840-jjm7y07m.txt plain text: cord-273840-jjm7y07m.txt item: #57 of 235 id: cord-273956-mruywa71 author: Mathers, Amy J title: The practical challenges of making clinical use of the quantitative value for SARS-CoV-2 viral load across several dynamics date: 2020-07-10 words: 1328 flesch: 49 summary: However, based on the findings of Ct value tightly correlating with mortality and need for mechanical ventilation when patients present for hospital admission with Covid-19 infection this may need to change. However, there are several hurdles and nuances which need to be addressed to deploy Ct value as a meaningful clinical metric. keywords: value cache: cord-273956-mruywa71.txt plain text: cord-273956-mruywa71.txt item: #58 of 235 id: cord-275349-b35pt3mo author: Lenz, Heinz-Josef title: The Emergence of Baricitinib: A Story of Tortoises Versus Hares date: 2020-07-06 words: 1406 flesch: 29 summary: Baricitinib treatment over prolonged periods in RA patients has been associated with increased infections and thromboembolism, but the short duration of treatment in COVID-19 patients may mitigate against such side effects. One would be advised to remain vigilant of such signals reflecting thromboembolic or infection risk in randomized controlled trials testing a variety of immunomodulatory therapies in COVID-19 patients, either alone or in combination, especially in view of associations between clots and SARS-CoV-2 infection [10] . keywords: baricitinib; covid-19; patients; treatment cache: cord-275349-b35pt3mo.txt plain text: cord-275349-b35pt3mo.txt item: #59 of 235 id: cord-275454-an8xvow3 author: Clark, Andrew E title: Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Screening With Specimen Pools: Time to Swim, or Too Deep for Comfort? date: 2020-09-28 words: 1608 flesch: 40 summary: If people misinterpret negative test results as justification to relax their nonpharmacologic interventions (mask wearing), especially at traditionally social times like lunch and coffee breaks, the magnitude of disease spread could be significant. The study demonstrates sample pooling as a mechanism for both cost reduction and resource conservation, using a commercial molecular platform with a rapid turnaround time and strong analytical sensitivity. keywords: pooling; sample; sars; screening; testing cache: cord-275454-an8xvow3.txt plain text: cord-275454-an8xvow3.txt item: #60 of 235 id: cord-276995-b003vcdc author: Wiese, Andrew D title: Social distancing measures: evidence of interruption of seasonal influenza activity and early lessons of the SARS-CoV-2 pandemic date: 2020-06-20 words: 819 flesch: 25 summary: key: cord-276995-b003vcdc authors: Wiese, Andrew D; Everson, Jordan; Grijalva, Carlos G title: Social distancing measures: evidence of interruption of seasonal influenza activity and early lessons of the SARS-CoV-2 pandemic date: 2020-06-20 journal: Clin Infect Dis DOI: 10.1093/cid/ciaa834 sha: doc_id: 276995 cord_uid: b003vcdc nan M a n u s c r i p t The unprecedented enactment of social distancing measures in response to the SARS-CoV-2 pandemic -including city lockdowns, school closures, stay-at-home orders, case isolation, quarantine of contacts, etc.was aimed at reducing the transmission of the virus and its burden on healthcare systems. In this issue of the journal, Hyunju Lee and colleagues describe the use of national influenza surveillance data to assess the impact of social distancing measures, implemented in response to the SARS-CoV-2 pandemic, on seasonal influenza activity in Korea. keywords: influenza; measures; surveillance cache: cord-276995-b003vcdc.txt plain text: cord-276995-b003vcdc.txt item: #61 of 235 id: cord-277307-wabruzfs author: Gu, Wei title: Associations of Early COVID-19 Cases in San Francisco with Domestic and International Travel date: 2020-05-21 words: 1098 flesch: 43 summary: key: cord-277307-wabruzfs authors: Gu, Wei; Deng, Xianding; Reyes, Kevin; Hsu, Elaine; Wang, Candace; Sotomayor-Gonzalez, Alicia; Federman, Scot; Bushnell, Brian; Miller, Steve; Chiu, Charles title: Associations of Early COVID-19 Cases in San Francisco with Domestic and International Travel date: 2020-05-21 journal: Clin Infect Dis DOI: 10.1093/cid/ciaa599 sha: doc_id: 277307 cord_uid: wabruzfs In early-to-mid March 2020, 20 of 46 (43%) COVID-19 cases at a tertiary care hospital in San Francisco, California were travel-related. In particular, New York cases in the United States quickly surged from 22 to >10,000 between March 10 and 22 2 . keywords: cases; new; sars cache: cord-277307-wabruzfs.txt plain text: cord-277307-wabruzfs.txt item: #62 of 235 id: cord-277410-lt19mijb author: Salvatore, Phillip P title: Epidemiological Correlates of PCR Cycle Threshold Values in the Detection of SARS-CoV-2 date: 2020-09-28 words: 3289 flesch: 44 summary: While quantitative interpretation of Ct values is dependent on multiple factors including reaction conditions and amplification efficiency, a common theoretical value can provide a useful benchmark for interpreting Ct values: an increase of 3.3 units in Ct value corresponds to 10-fold less target RNA under optimum conditions [3] . Given the paucity of data examining associations of these factors with Ct value at the time of diagnosis, we sought to identify relationships between Ct values and time since onset, demographic factors, and symptoms among laboratory-confirmed COVID-19 cases identified in a multistate investigation of SARS-CoV-2 household transmission. and Wisconsin between March 23 and May 13, 2020 who tested positive for SARS-CoV-2 on an nasopharyngeal (NP) swab at enrollment or during follow-up, including index cases and household members [10] [11] [12] . keywords: collection; cov-2; participants; sars; symptoms; time; values cache: cord-277410-lt19mijb.txt plain text: cord-277410-lt19mijb.txt item: #63 of 235 id: cord-277611-3iynrfzq author: Buetti, Niccolò title: Risk factors for SARS-CoV-2 detection in blood of critically ill patients date: 2020-09-02 words: 812 flesch: 59 summary: This model takes into account the clustering effect of multiple sampling per patient. patients were male and the median age was 58 (IQR: 46; 67); 22 (52%) had a cardiovascular comorbidity and eight (19%) were immunosuppressed. keywords: patients; sars cache: cord-277611-3iynrfzq.txt plain text: cord-277611-3iynrfzq.txt item: #64 of 235 id: cord-277788-6ls21tkr author: Nelson, Brian C title: Clinical Outcomes Associated with Methylprednisolone in Mechanically Ventilated Patients with COVID-19 date: 2020-08-09 words: 3556 flesch: 45 summary: On behalf of the Working Group on Sepsis-Related Problems of the European Society of Intensive Care Medicine Clinical management of severe acute respiratory infection when COVID-19 is suspected Corticosteroids as adjunctive therapy in the treatment of influenza: an updated cochrane systematic review and meta-analysis Factors associated with psychosis among patients with severe acute Respiratory Syndrome: a case-control study Efficacy and safety of corticosteroids for persistent acute respiratory distress syndrome Effect of hypercortisone on development of shock among patients with severe sepsis Hydrocortisone therapy for patients with septic shock Early short course corticosteroids in hospitalized patients with COVID-19 Effect of systemic glucocorticoids on mortality or mechanical ventilation in patients with COVID-19 A c c e p t e d M a n u s c r i Clinical outcomes associated with the use of methylprednisolone were assessed in an unmatched, case-control study; a subset of patients also underwent propensity-score matching. keywords: corticosteroids; covid-19; days; methylprednisolone; patients; study cache: cord-277788-6ls21tkr.txt plain text: cord-277788-6ls21tkr.txt item: #65 of 235 id: cord-278045-hr3r17mz author: Yokota, Isao title: Mass screening of asymptomatic persons for SARS-CoV-2 using saliva date: 2020-09-25 words: 2276 flesch: 40 summary: Saliva samples were self-collected in a sterilized 15mL polystyrene sputum collection tube (Toyo Kizai, Warabi, Japan) at partitioned booth. Previous studies comparing the viral load between NPS and saliva samples report Investigation of a COVID-19 outbreak in Germany resulting from a single travel-associated primary case: a case series Presumed Asymptomatic Carrier Transmission of COVID-19 The implications of silent transmission for the control of COVID-19 outbreaks The promise and peril of antibody testing for COVID-19 Detection of SARS-CoV-2 in Different Types of Clinical Specimens Comparison of nasopharyngeal and oropharyngeal swabs for SARS-CoV-2 detection in 353 patients received tests with both specimens simultaneously Consistent detection of 2019 novel coronavirus in saliva Saliva is a reliable tool to detect SARS-CoV-2 Saliva as a Noninvasive Specimen for Detection of SARS-CoV-2 Swabs collected by patients or health care workers for SARS-CoV-2 testing Comparison of SARS-CoV-2 detection in nasopharyngeal swab and saliva Clinical evaluation of self-collected saliva by RT-qPCR, direct RT-qPCR, RT-LAMP, and a rapid antigen test to diagnose COVID-19 Loop-mediated isothermal amplification of DNA Development of Reverse Transcription Loop-Mediated Isothermal Amplification Assays keywords: asymptomatic; detection; nps; pcr; saliva; sars cache: cord-278045-hr3r17mz.txt plain text: cord-278045-hr3r17mz.txt item: #66 of 235 id: cord-278084-km04sz2s author: Martino, Rodrigo title: Respiratory Virus Infections in Adults with Hematologic Malignancies: A Prospective Study date: 2003-01-01 words: 3124 flesch: 43 summary: key: cord-278084-km04sz2s authors: Martino, Rodrigo; Rámila, Elena; Rabella, Núria; Muñoz, José Manuel; Peyret, Mercé; Portos, José Manuel; Laborda, Rosario; Sierra, Jorge title: Respiratory Virus Infections in Adults with Hematologic Malignancies: A Prospective Study date: 2003-01-01 journal: Clin Infect Dis DOI: 10.1086/344899 sha: doc_id: 278084 cord_uid: km04sz2s During a 2-year period, 157 consecutive episodes of respiratory virus infections that occurred in 130 patients with upper or lower respiratory tract infection were analyzed for respiratory viruses. Despite an increasing number of reports, there have been few prospective studies of respiratory virus infections in adults with hematologic malignancies. keywords: infections; lrti; patients; respiratory; urti; virus cache: cord-278084-km04sz2s.txt plain text: cord-278084-km04sz2s.txt item: #67 of 235 id: cord-278259-pbnnp9i1 author: Choi, Eun Hwa title: The Association of Newly Identified Respiratory Viruses with Lower Respiratory Tract Infections in Korean Children, 2000–2005 date: 2006-09-01 words: 3722 flesch: 46 summary: The etiologic and epidemiologic spectrum of bronchiolitis in pediatric practice Occurrence of groups A and B of respiratory syncytial virus over 15 years: associated epidemiologic and clinical characteristics in hospitalized and ambulatory children Viral etiology and epidemiology of acute lower respiratory tract infections in Korean children Lower respiratory tract infections due to adenovirus in hospitalized Korean children: epidemiology, clinical features, and prognosis Association of rhinovirus infection with increased disease severity in acute bronchiolitis The role of rhinovirus in asthma exacerbations Rhinovirus viremia in children with respiratory infections A newly discovered human pneumovirus isolated from young children with respiratory tract disease Identification of a new human coronavirus A previously undescribed coronavirus associated with respiratory disease in humans Cloning of a human parvovirus by molecular screening of respiratory tract samples Coronavirus infection in acute lower respiratory tract disease of infants Acute lower respiratory tract infections in nonhospitalized children Rapid identification of human adenovirus types 3 and 7 from respiratory specimens via multiplex type-specific PCR Practical implementation of a multiplex PCR for acute respiratory tract infections in children Rhinovirus identification by BglI digestion of picornavirus RT-PCR amplicons Type-specific identification of influenza viruses A, B, and C by the polymerase chain reaction Evidence of a novel human coronavirus that is associated with respiratory tract disease in infants and young children Evidence of human coronavirus HKU1 and human bocavirus in Australian children 50% Endpoint calculation Human metapneumovirus infections in hospitalized children Human metapneumovirus in children tested at a tertiary-care hospital New human coronavirus, HCoV-NL63, associated with severe lower respiratory tract disease in Australia Human coronavirus NL63 infection and other coronavirus infections in children hospitalized with acute respiratory disease in Hong Kong, China Seasonality and clinical features of human metapneumovirus infection in children in Northern Alberta Human metapneumovirus-associated lower respiratory tract infections in Korean infants and young children Human metapneumovirus and lower respiratory tract disease in otherwise healthy infants and children Human metapneumovirus infection in Japanese children Detection of human coronavirus NL63 in young children with bronchiolitis Human coronavirus NL-63 infections in children: a 1-year study Detection of human coronavirus-NL63 in children in Japan Human coronavirus NL63 associated with lower respiratory tract symptoms in early life Croup is associated with the novel coronavirus NL63 Croup: an 11-year study in a pediatric practice Respiratory syncytial virus and parainfluenza virus Genetic diversity and molecular epidemiology of the G protein of subgroups A and B of respiratory syncytial viruses isolated over 9 consecutive epidemics in Korea Specifically, we evaluated the relative prevalences and the epidemiologic characteristics of rhinovirus, hMPV, conventional HCoV, HCoV-NL63, and HBoV and compared these findings with those of common respiratory viruses, such as RSV, PIV, adenovirus, and influenza virus. keywords: children; hbov; hcov; hmpv; infections; nl63; viruses cache: cord-278259-pbnnp9i1.txt plain text: cord-278259-pbnnp9i1.txt item: #68 of 235 id: cord-279167-fj36mzm5 author: Gwaltney, Jack M. title: Acute Community-Acquired Sinusitis date: 1996-12-17 words: 8374 flesch: 39 summary: In a rabbit model, maxillary sinus infection with S. pneumoniae or H. injluenzae resulted in a modest increase in ciliarybeat frequency for 2 to 3 days, which was followed by marked destruction of ciliated epithelial cells, starting on day 2 (s. pneumoniae) and day 4 (H. injluenzae) In addition, the recent development of computed tomography (CT) has provided a powerful tool for studying the pathogenesis of sinus infections and for em 1996; 23 (December) improved management of cases, especially those of chronic sinus disease. keywords: acabs; acute; aspirate; bacteria; cases; cavity; infection; maxillary; nasal; patients; rhinovirus; sinus; sinus cavity; sinuses; sinusitis; treatment cache: cord-279167-fj36mzm5.txt plain text: cord-279167-fj36mzm5.txt item: #69 of 235 id: cord-279550-7u2hksxm author: Wang, Kai title: Longitudinal dynamics of the neutralizing antibody response to SARS-CoV-2 infection date: 2020-08-03 words: 2671 flesch: 47 summary: Moreover, a SARS-CoV A c c e p t e d M a n u s c r i p t 14 antigen-specific memory B cell response was not detectable in recovered SARS patients at 6-years after disease onset, whereas SARS-CoV-specific memory T cells persisted in recovered SARS patients. NAb titers increased over time in parallel with the rise in IgG antibody levels, correlating well at week 3 (r = 0·41, p & 0·05). keywords: cov-2; covid-19; levels; nab; nabs; patients; sars cache: cord-279550-7u2hksxm.txt plain text: cord-279550-7u2hksxm.txt item: #70 of 235 id: cord-279828-es498qul author: Boulle, Andrew title: Risk factors for COVID-19 death in a population cohort study from the Western Cape Province, South Africa date: 2020-08-29 words: 3653 flesch: 35 summary: COVID-19 in patients with HIV: clinical case series Clinical features and outcomes of HIV patients with coronavirus disease 2019 COVID-19 in people living with human immunodeficiency virus: a case series of 33 patients COVID-19 in patients with HIV A Case Series of Five People Living with HIV Hospitalized with COVID-19 in Clinical characteristics and outcomes in people living with HIV hospitalized for COVID-19 Description of COVID-19 in HIV-infected individuals: a single-centre, prospective cohort OpenSAFELY: factors associated with COVID-19 death in 17 million patients Dysregulation of immune response in patients with COVID-19 in Wuhan, China Lymphopenia predicts disease severity of COVID-19: a descriptive and predictive study Could HIV infection alter the clinical course of SARS-CoV-2 infection? We also calculated the standardized mortality ratio (SMR) of the actual number of COVID-19 deaths in PLWH vs. the number that would be expected if PLWH had the same risk of COVID-19 death as HIV-negative people of the same age and sex. keywords: art; cases; covid-19; covid-19 death; death; hiv; mortality; patients; plwh; risk; sector; tuberculosis cache: cord-279828-es498qul.txt plain text: cord-279828-es498qul.txt item: #71 of 235 id: cord-279932-bilr71ay author: Plotkin, Stanley A title: The Value of Human Challenges in Severe Acute Respiratory Syndrome Coronavirus 2 Vaccine Development date: 2020-07-16 words: 1120 flesch: 41 summary: [7] elsewhere, have proposed the use of human challenge trials as a way of confirming the protective ability of candidate vaccines, in order to allow emergency use in high-risk groups and to facilitate the way to eventual licensure and use in the general population. The idea behind human challenge trials is to recruit young, healthy volunteers who have the lowest chance of serious disease, who would be given vaccine candidates and then be challenged with SARS-CoV-2 in order to determine whether the vaccines protect. keywords: challenge; disease; vaccine cache: cord-279932-bilr71ay.txt plain text: cord-279932-bilr71ay.txt item: #72 of 235 id: cord-280005-i9fp5rys author: Wang, Mengmei title: Treatment of COVID-19 Patients with Prolonged Post-Symptomatic Viral Shedding with Leflunomide -- a Single-Center, Randomized, Controlled Clinical Trial date: 2020-09-21 words: 3192 flesch: 42 summary: key: cord-280005-i9fp5rys authors: Wang, Mengmei; Zhao, Yang; Hu, Weihua; Zhao, Dong; Zhang, Yunting; Wang, Tao; Zheng, Zhishui; Li, Xiaochen; Zeng, Shaolin; Liu, Zhenlian; Lu, Li; Wan, Zhihui; Hu, Ke title: Treatment of COVID-19 Patients with Prolonged Post-Symptomatic Viral Shedding with Leflunomide -- a Single-Center, Randomized, Controlled Clinical Trial date: 2020-09-21 journal: Clin Infect Dis DOI: 10.1093/cid/ciaa1417 sha: doc_id: 280005 cord_uid: i9fp5rys OBJECTIVE: To evaluate the efficacy and safety of leflunomide, an approved dihydroorotate dehydrogenase inhibitor, to treat COVID-19 patients with prolonged post-symptomatic viral shedding. In COVID-19 patients with prolonged PCR positivity, no benefit in terms of the duration of viral shedding was observed with the combined treatment of leflunomide and IFN α-2a beyond IFN α-2a alone. keywords: covid-19; days; group; leflunomide; patients; shedding; treatment; trial cache: cord-280005-i9fp5rys.txt plain text: cord-280005-i9fp5rys.txt item: #73 of 235 id: cord-280571-ntgt5hy9 author: Ginocchio, Christine C. title: Strengths and Weaknesses of FDA-Approved/Cleared Diagnostic Devices for the Molecular Detection of Respiratory Pathogens date: 2011-05-01 words: 7524 flesch: 35 summary: Approved tests have undergone extensive analytical and clinical validations during the course of the FDA evaluations. In addition, during the first weeks of the 2009 influenza A H1N1 outbreak in the spring of 2009, multiple influenza viruses were cocirculating [5] . keywords: assay; detection; fda; influenza; laboratories; naats; respiratory; rsv; test; testing; time; tuberculosis; use; virus cache: cord-280571-ntgt5hy9.txt plain text: cord-280571-ntgt5hy9.txt item: #74 of 235 id: cord-280763-4bnv2t3f author: Piñana, José Luis title: Clinical Effectiveness of Influenza Vaccination After Allogeneic Hematopoietic Stem Cell Transplantation: A Cross-sectional, Prospective, Observational Study date: 2019-06-01 words: 4163 flesch: 30 summary: A multivariate analysis showed that influenza vaccination was associated with a lower prevalence of influenza RVI (odds ratio A multivariate risk factor analysis of lower–respiratory tract disease (LRTD) identified 2 conditions associated with the probability of influenza RVI progression: influenza vaccination (OR 0.12, 95% confidence interval [CI] 0.014–1, P = .05) and a high-risk immunodeficiency score (OR 36, 95% CI 2.26–575, P = .011). keywords: allo; cell; episodes; hsct; influenza; recipients; rvi; transplant; vaccination; virus cache: cord-280763-4bnv2t3f.txt plain text: cord-280763-4bnv2t3f.txt item: #75 of 235 id: cord-280915-yk872yaz author: Flaherman, Valerie J title: Infant Outcomes Following Maternal Infection with SARS-CoV-2: First Report from the PRIORITY Study date: 2020-09-18 words: 1529 flesch: 40 summary: Our cohort of 263 infants included 179 and 84, respectively, born to mothers testing positive or negative for SARS CoV-2. t 5 See the Table for other clinical and demographic characteristics by maternal SARS CoV-2 status. keywords: cov-2; infants; mothers; sars cache: cord-280915-yk872yaz.txt plain text: cord-280915-yk872yaz.txt item: #76 of 235 id: cord-280954-wd89nka9 author: Ackerson, Bradley title: Severe Morbidity and Mortality Associated With Respiratory Syncytial Virus Versus Influenza Infection in Hospitalized Older Adults date: 2019-07-15 words: 3607 flesch: 31 summary: Comparison of RSV and influenza infection in hospitalized older adults may increase awareness of adult RSV disease burden. Increased recognition of adult RSV disease burden will be important in the evaluation and use of new RSV vaccines and antivirals. keywords: adults; infection; influenza; rsv; virus cache: cord-280954-wd89nka9.txt plain text: cord-280954-wd89nka9.txt item: #77 of 235 id: cord-280958-36ytqapi author: Decker, Summer J title: 3D Printed Alternative to the Standard Synthetic Flocked Nasopharyngeal Swabs Used for COVID-19 testing date: 2020-09-10 words: 3517 flesch: 55 summary: As this study was developed in response to a critical shortage of testing swabs, our hospitals were unable to provide large FLNP swab samples to be used for clinical trial. However, disruption in the medical supply chain [13] caused by this crisis resulted in test kit shortages, including FLNP swabs. keywords: 3dp; covid-19; flnp; swab; testing cache: cord-280958-36ytqapi.txt plain text: cord-280958-36ytqapi.txt item: #78 of 235 id: cord-281418-mvgp6qfv author: Soccal, P. M. title: Upper and Lower Respiratory Tract Viral Infections and Acute Graft Rejection in Lung Transplant Recipients date: 2010-07-15 words: 3563 flesch: 35 summary: Clinical impact of communityacquired respiratory viruses on bronchiolitis obliterans after lung transplant Impact of human metapneumovirus and human cytomegalovirus versus other respiratory viruses on the lower respiratory tract infections of lung transplant recipients Respiratory viruses and chronic rejection in lung transplant recipients Human metapneumovirus in lung transplant recipients and comparison to respiratory syncytial virus Respiratory viral infections in transplant recipients A single-season prospective study of respiratory viral infections in lung transplant recipients Absence of human bocavirus in bronchoalveolar lavage fluid of lung transplant patients Diagnosis of human metapneumovirus infection in immunosuppressed lung transplant recipients and children evaluated for pertussis Detection of severe human metapneumovirus infection by real-time polymerase chain reaction and histopathological assessment Human metapneumovirus infection in lung transplant recipients: clinical presentation and epidemiology Lower respiratory viral illnesses: improved diagnosis by molecular methods and clinical impact Respiratory viral infections are a distinct risk for bronchiolitis obliterans syndrome and death Clinical features and outcomes of paramyxoviral infection in lung transplant recipients treated with ribavirin Infectious etiology of bronchiolitis obliterans: the respiratory viruses connection: myth or reality? Characterization of virus-mediated inhibition of mixed chimerism and allospecific tolerance Critical role for the chemokine MCP-1/CCR2 in the pathogenesis of bronchiolitis obliterans syndrome Community acquired respiratory viral infections after lung transplantation: clinical features and long-term consequences Parainfluenza virus infection in adult lung transplant recipients: an emergent clinical syndrome with implications on allograft function The epidemiology of parainfluenza virus infection in lung transplant recipients Treatment of respiratory syncytial virus pneumonia in a lung transplant recipient: case report and review of the literature Influenza virus infection in adult solid organ transplant recipients Respiratory viruses in bronchoalveolar lavage: a hospital-based cohort study in adults A prospective hospital-based study of the clinical impact of non-severe acute respiratory syndrome (non-SARS)-related human coronavirus infection Swiss Paediatric Respiratory Research Group. Paradoxically, we even observed a negative association between an episode of respiratory viral infection and the subsequent cumulative risk of developing acute rejection. keywords: bal; infection; lung; presence; rejection; transplant; viruses cache: cord-281418-mvgp6qfv.txt plain text: cord-281418-mvgp6qfv.txt item: #79 of 235 id: cord-281726-s1o5l7ns author: Yu, Ignatius T. S. title: Temporal-Spatial Analysis of Severe Acute Respiratory Syndrome among Hospital Inpatients date: 2005-05-01 words: 3530 flesch: 54 summary: We checked the bed movements (transfers) of the inpatients during the study period and found that none of the inpatients with SARS were moved to other beds after the onset of fever and, thus, could not have played a role in the spread of the infection to other bays. Lebanon, NH: Fluent Insights into the epidemiology and control of infection with vancomycin-resistant enterococci Epidemiology of Clostridium difficile-associated infections Clinical progress and viral load in a community outbreak of coronavirus-associated SARS pneumonia: a prospective study Index patient and SARS outbreak in Hong Kong Airborne transmission of communicable infection-the elusive pathway SARS: experience at Prince of Wales Hospital, Hong Kong We gratefully acknowledge the assistance of Xinghua Huang (Shanghai Jiao Tong University, Shanghai) and Hua Qian (University of Hong Kong, Hong Kong SAR) with CFD simulations and field measurements. keywords: case; index; inpatients; march; sars; spread; ward cache: cord-281726-s1o5l7ns.txt plain text: cord-281726-s1o5l7ns.txt item: #80 of 235 id: cord-282539-skzosh6u author: Casadevall, Arturo title: Implications of Coronavirus Disease 2019 (COVID-19) Antibody Dynamics for Immunity and Convalescent Plasma Therapy date: 2020-08-17 words: 1590 flesch: 44 summary: Longitudinal dynamics of the neutralizing antibody response to SARS-CoV-2 infection Kinetics of viral load and antibody response in relation to COVID-19 severity Convalescent plasma treatment for SARS-CoV-2 infection: analysis of the first 436 donors in England Immune responses during measles virus infection Duration of immunity to norovirus gastroenteritis Exploiting the redundancy in the immune system: vaccines can mediate protection by eliciting 'unnatural' immunity Effectiveness of convalescent plasma therapy in severe COVID-19 patients Effect of convalescent plasma therapy on time to clinical improvement in patients with severe and life-threatening COVID-19: a randomized clinical trial Mortality reduction in 46 severe COVID-19 patients treated with hyperimmune plasma: a proof of concept single arm multicenter trial SARS-CoV-2 viral load and antibody responses: the case for convalescent plasma therapy Given that current recommendations for plasma donation advise waiting 4 weeks after the resolution of symptoms to ensure viral clearance and a rise in convalescent antibody titer, the preferred window for plasma collection begins at 4 weeks and could narrow rapidly by 12 weeks. keywords: antibody; cov-2; plasma; sars cache: cord-282539-skzosh6u.txt plain text: cord-282539-skzosh6u.txt item: #81 of 235 id: cord-283780-h4lwzpl9 author: Zhang, John J Y title: Risk Factors of Severe Disease and Efficacy of Treatment in Patients Infected with COVID-19: A Systematic Review, Meta-Analysis and Meta-Regression Analysis date: 2020-05-14 words: 3122 flesch: 43 summary: At baseline, the quality of evidence derived from a review of COVID-19 studies was assessed as low, owing to their observational nature. The quality of included studies was assessed using the Joanna Briggs Institute (JBI) checklist for prevalence studies and the JBI checklist for case series [10] . keywords: analysis; covid-19; meta; patients; studies cache: cord-283780-h4lwzpl9.txt plain text: cord-283780-h4lwzpl9.txt item: #82 of 235 id: cord-283788-04gwxo4b author: Pinninti, Swetha title: Comparing Nasopharyngeal and Mid-Turbinate Nasal Swab Testing for the Identification of SARS-CoV-2 date: 2020-06-29 words: 1052 flesch: 48 summary: Moreover, MT swab testing is gaining wider acceptance due to the ease of sample collection, ability to self-collect and personal protective equipment may not be needed [8] . The objective of this study is to determine whether MT swabs are comparable to NP swabs in detecting SARS-CoV-2 by RT-PCR in patients with confirmed COVID-19. keywords: swabs cache: cord-283788-04gwxo4b.txt plain text: cord-283788-04gwxo4b.txt item: #83 of 235 id: cord-284782-51mbq7qb author: Huang, Jing title: Care for the psychological status of frontline medical staff fighting against COVID-19 date: 2020-04-03 words: 314 flesch: 39 summary: More medical teams were then sent out to the hardest-hit areas in Hubei province, including rescue and medical teams from different provinces, the army medical teams, specialized doctors and nurses' teams, and emergency medical teams from different hospitals. For example, the emergency medical team from the Second Xiangya Hospital is able to set up field hospitals and ambulances to help and serve the With the increasing spreading of the virus worldwide, COVID-19 outbreak is now becoming a pandemic. keywords: covid-19 cache: cord-284782-51mbq7qb.txt plain text: cord-284782-51mbq7qb.txt item: #84 of 235 id: cord-285403-h8ahn8fw author: Zhang, Liangsheng title: Origin and Evolution of the 2019 Novel Coronavirus date: 2020-02-03 words: 850 flesch: 53 summary: This indicates that there should be more bat viruses closer to 2019-nCoV. According to their phylogenetic relationships, the 27 isolates of 2019-nCoV examined in this study can be divided into at least 6 genotypes (I-VI; Figure 1C ). The 2019-nCoV has infected several hundred humans and has caused many fatal cases. keywords: 2019; ncov cache: cord-285403-h8ahn8fw.txt plain text: cord-285403-h8ahn8fw.txt item: #85 of 235 id: cord-287119-eo0evoog author: Kendall, Emily A title: When infections don’t reflect infectiousness: interpreting contact investigation data with care date: 2020-08-08 words: 1579 flesch: 36 summary: More importantly, regardless of mechanism, the measured M a n u s c r i p t burden of infection and disease in contacts of HIV-positive TB index cases has clear policy implications: Contacts of TB patients are at high risk for TB, and contacts of HIV-positive TB patients have nearly as high a risk of TB (and a much higher risk of HIV) than other TB contacts. In South Korea's recent contact study, the authors noted they could not determine direction of transmission, and the data do not fully support the widespread interpretation of the proportion of contacts infected as a measure of index case infectiousness. keywords: contact; hiv; index cache: cord-287119-eo0evoog.txt plain text: cord-287119-eo0evoog.txt item: #86 of 235 id: cord-287676-qh7zeyyx author: Angoulvant, François title: COVID-19 pandemic: Impact caused by school closure and national lockdown on pediatric visits and admissions for viral and non-viral infections, a time series analysis date: 2020-06-03 words: 1815 flesch: 44 summary: M a n u s c r i p t Impact of lockdown on weekly pediatric emergency department visits and major pediatric infectious diseases, from January 1 st , 2017 to April 19 th , 2020. We hypothesized that this unusual situation in France would be associated with a sharp decrease in pediatric infectious diseases that usually disseminate through social contacts, with schools at their center. keywords: analysis; decrease; lockdown; visits cache: cord-287676-qh7zeyyx.txt plain text: cord-287676-qh7zeyyx.txt item: #87 of 235 id: cord-287923-ev93r09i author: Apisarnthanarak, Anucha title: Infection Prevention and Control in Asia: Current Evidence and Future Milestones date: 2017-05-15 words: 1312 flesch: 21 summary: Although infection prevention and control is well recognized in the Asia-Pacific region, there are inconsistencies in the quality of evidence and dedicated resources to enhance current infection prevention practices, surveillance, and patient safety [4] [5] [6] . In resource-limited settings, relative to resource-adequate settings, there continues to be a paucity of data in support of infection prevention and control, and patient safety interventions to ensure that regional, if not national, healthcare systems work effectively to improve infection prevention and control interventions. keywords: asia; control; infection; pacific; prevention cache: cord-287923-ev93r09i.txt plain text: cord-287923-ev93r09i.txt item: #88 of 235 id: cord-288432-n2y9cunc author: Liu, Kun title: Population movement, city closure in Wuhan and geographical expansion of the 2019-nCoV pneumonia infection in China in January 2020 date: 2020-04-17 words: 2372 flesch: 45 summary: The net loss index of outflow population caused by advanced Wuhan city closure for each province: 11 A c c e p t e d M a n u s c r i p t 10 Similarly, we evaluated the impacts of one-day and two-day delayed city closure. METHODS: Based on the daily reported new cases and the population movement data between January 1 and 31, we examined the effects of population outflow from Wuhan on the geographical expansion of the infection in other provinces and cities of China, as well as the impacts of the city closure in Wuhan in different scenarios of closing dates. keywords: cases; china; p t; population; wuhan cache: cord-288432-n2y9cunc.txt plain text: cord-288432-n2y9cunc.txt item: #89 of 235 id: cord-288558-rthnj6wd author: Cheng, V. C. C. title: Viral Replication in the Nasopharynx Is Associated with Diarrhea in Patients with Severe Acute Respiratory Syndrome date: 2004-02-15 words: 3807 flesch: 42 summary: Summary table of SARS cases by country A novel coronavirus associated with severe acute respiratory syndrome Identification of a novel coronavirus in patients with severe acute respiratory syndrome Coronavirus as a possible cause of severe acute respiratory syndrome Koch's postulates fulfilled for SARS virus Newly discovered coronavirus as the primary cause of severe acute respiratory syndrome Clinical progression and viral load in a community outbreak of coronavirus-associated SARS pneumonia: a prospective study Detection of SARS coronavirus (SCoV) by RT-PCR, culture, and serology in patients with acute respiratory syndrome (SARS) The lung and the gastrointestinal tract may react differently to SARS coronavirus infection. keywords: coronavirus; days; diarrhea; onset; patients; sars; severe; symptoms; syndrome cache: cord-288558-rthnj6wd.txt plain text: cord-288558-rthnj6wd.txt item: #90 of 235 id: cord-289247-qc3to2xj author: Yamaoka, Yutaro title: Whole nucleocapsid protein of SARS-CoV-2 may cause false positive results in serological assays date: 2020-05-23 words: 730 flesch: 47 summary: This was pointed out by Yu et al in SARS-CoV, who observed cross reactivity of whole NP with other Coronaviruses and encountered high rates of false positivity while testing healthy donor sera [2] . key: cord-289247-qc3to2xj authors: Yamaoka, Yutaro; Jeremiah, Sundararaj S; Miyakawa, Kei; Saji, Ryo; Nishii, Mototsugu; Takeuchi, Ichiro; Ryo, Akihide title: Whole nucleocapsid protein of SARS-CoV-2 may cause false positive results in serological assays date: 2020-05-23 journal: Clin Infect Dis DOI: 10.1093/cid/ciaa637 sha: doc_id: 289247 cord_uid: qc3to2xj nan M a n u s c r i p t 2 TO THE EDITOR - The nucleocapsid protein (NP) of SARS-CoV-2 is one of the widely used antigens in serodiagnostics of the novel Coronavirus disease . keywords: sars cache: cord-289247-qc3to2xj.txt plain text: cord-289247-qc3to2xj.txt item: #91 of 235 id: cord-289598-t8upoq9a author: Yoon, Jane C title: COVID-19 Prevalence among People Experiencing Homelessness and Homelessness Service Staff during Early Community Transmission in Atlanta, Georgia, April–May 2020 date: 2020-09-08 words: 2985 flesch: 46 summary: Shelter staff were counseled on best practices to prevent transmission in the shelter. Shelter clients might not have disclosed symptoms due to fears that they would be removed from shelters. keywords: cov-2; peh; sars; shelters; staff; testing cache: cord-289598-t8upoq9a.txt plain text: cord-289598-t8upoq9a.txt item: #92 of 235 id: cord-290133-4ou7ubb4 author: Weiss, Martin M. title: Rethinking Smallpox date: 2004-12-01 words: 3977 flesch: 48 summary: A focus on the hazards of smallpox vaccination without consideration of the potential consequences of a competently executed smallpox attack may lead to skewed analyses and flawed decisions. Review of the Centers for Disease Control and Prevention's smallpox vaccination program implementation: letter report #4 Evaluation of 21st-century risks of smallpox vaccination and policy options Smallpox vaccine policy is bad science Harrison's principles of internal medicine Bio-terrorism, NIH-CDC grand rounds US hunting antiviral drug to use in case of smallpox Ammo for the war on germs In vitro activity of potential anti-poxvirus agents Expression of mouse interleukin-4 by a recombinant ectromelia virus suppresses cytolytic lymphocyte responses and overcomes genetic resistance to mousepox Smallpox: anything to declare? keywords: attack; cases; health; methisazone; public; smallpox; vaccination; vaccine; virus cache: cord-290133-4ou7ubb4.txt plain text: cord-290133-4ou7ubb4.txt item: #93 of 235 id: cord-291286-diwigcy9 author: De Schutter, Iris title: Microbiology of Bronchoalveolar Lavage Fluid in Children With Acute Nonresponding or Recurrent Community-Acquired Pneumonia: Identification of Nontypeable Haemophilus influenzae as a Major Pathogen date: 2011-06-15 words: 4080 flesch: 36 summary: A heterogeneous group of patients was included, which reflected pediatric CAP cases that often require hospitalization in developed countries. NR-CAP case patients were defined according to current pediatric CAP guidelines [15] as patients with persistent fever (.38.5°C) and persistent elevated infection parameters in the peripheral blood, associated in some cases with worsening consolidation visible on chest radiographs after at least 48 h of antibiotic treatment. keywords: bal; cap; cases; children; influenzae; patients; pneumonia; rec cache: cord-291286-diwigcy9.txt plain text: cord-291286-diwigcy9.txt item: #94 of 235 id: cord-291363-re45w37d author: Sanville, Bradley title: A Community Transmitted Case of Severe Acute Respiratory Distress Syndrome due to SARS CoV2 in the United States date: 2020-03-30 words: 1312 flesch: 43 summary: While the majority of COVID-19 cases were identified within our patient's age group years), only 18.5% of severe cases were from this age group. Those over the age of 65 comprised 49.2% of severe cases 6, 9 . keywords: coronavirus; cov2; novel; patient; sars cache: cord-291363-re45w37d.txt plain text: cord-291363-re45w37d.txt item: #95 of 235 id: cord-291726-8670s4st author: Che, Xiao-yan title: A Patient with Asymptomatic Severe Acute Respiratory Syndrome (SARS) and Antigenemia from the 2003–2004 Community Outbreak of SARS in Guangzhou, China date: 2006-07-01 words: 2591 flesch: 37 summary: This finding, together with the previously reported findings of serological analysis of the handlers of wild animals and the 4 index case patients from the community outbreak of SARS in 2004, reveals that there likely is an intermediate epidemiological phase, which might be critical for genetic adaptation of the virus to its new hosts before critical mutation enables it to eventually cause severe symptomatic SARS, as was seen in early 2003. However, in the 2003-2004 community outbreak of SARS, none of the 4 index case patients with confirmed SARS had severe illness, and they all seemed to have acquired infection with SARS-CoV directly from animals. keywords: case; cov; patient; sars; serum cache: cord-291726-8670s4st.txt plain text: cord-291726-8670s4st.txt item: #96 of 235 id: cord-292094-vmsdhccp author: Mandell, Lionel A. title: Infectious Diseases Society of America/American Thoracic Society Consensus Guidelines on the Management of Community-Acquired Pneumonia in Adults date: 2007-03-01 words: 28417 flesch: 34 summary: A statewide initiative to improve the care of hospitalized pneumonia patients: The Connecticut Pneumonia Pathway Project Implementation of an evidencebased guideline to reduce duration of intravenous antibiotic therapy and length of stay for patients hospitalized with community-acquired pneumonia: a randomized controlled trial Improving the quality of care for patients with pneumonia in very small hospitals Early mobilization of patients hospitalized with community-acquired pneumonia A comparison of enoxaparin with placebo for the prevention of venous thromboembolism in acutely ill medical patients. For other patients with CAP, the recommendations for diagnostic testing focus on patients in whom the diagnostic yield is thought to be greatest. keywords: admission; adults; antibiotic; cap; care; community; criteria; culture; disease; evidence; factors; guidelines; hospital; icu; infection; influenza; level; management; mortality; pathogens; patients; pneumococcal; pneumonia; recommendation; resistance; respiratory; results; risk; sputum; studies; study; therapy; treatment; use cache: cord-292094-vmsdhccp.txt plain text: cord-292094-vmsdhccp.txt item: #97 of 235 id: cord-292372-kn27ghlv author: de Chaisemartin, Clément title: BCG vaccination in infancy does not protect against COVID-19. Evidence from a natural experiment in Sweden date: 2020-08-23 words: 2820 flesch: 50 summary: key: cord-292372-kn27ghlv authors: de Chaisemartin, Clément; de Chaisemartin, Luc title: BCG vaccination in infancy does not protect against COVID-19. We used regression discontinuity to assess the effect of BCG vaccination on Covid-19 related outcomes. keywords: bcg; cases; covid-19; effect; vaccination cache: cord-292372-kn27ghlv.txt plain text: cord-292372-kn27ghlv.txt item: #98 of 235 id: cord-292546-un0blb3w author: Dandachi, Dima title: Characteristics, Comorbidities, and Outcomes in a Multicenter Registry of Patients with HIV and Coronavirus Disease-19 date: 2020-09-09 words: 3441 flesch: 50 summary: Infection Clinical features and outcomes of HIV patients with coronavirus disease 2019 Outcomes among HIV-positive patients hospitalized with COVID-19 Covid-19 and People with HIV Infection: Outcomes for Hospitalized Patients Clinical characteristics, comorbidities and outcomes among persons with HIV hospitalized with coronavirus disease Description of COVID-19 in HIV-infected individuals: a single-centre, prospective cohort. Ongoing research aims to determine the impact of structural racism in COVID-19 outcomes. keywords: covid-19; hiv; outcomes; patients cache: cord-292546-un0blb3w.txt plain text: cord-292546-un0blb3w.txt item: #99 of 235 id: cord-294335-qnu19ru5 author: Yousaf, Anna R title: A prospective cohort study in non-hospitalized household contacts with SARS-CoV-2 infection: symptom profiles and symptom change over time date: 2020-07-28 words: 3232 flesch: 41 summary: For symptoms experienced throughout the illness, the percent of household contacts reporting neurologic symptoms increased to 94% (n=44), predominated by headache (n=41, 87%), followed by upper respiratory symptoms (n=42, 89%). Among the different age groups, the most common symptoms were as follows: upper respiratory symptoms in children <18 years (n=10, 71%), neurologic symptoms in adults 18-49 years (n=14, 70%), and upper respiratory symptoms in adults 50 years or older (n=11, 85%). keywords: contacts; covid-19; day; household; pcr; symptoms; years cache: cord-294335-qnu19ru5.txt plain text: cord-294335-qnu19ru5.txt item: #100 of 235 id: cord-294558-cqa58db8 author: Wang, Yubo title: Characterization of an asymptomatic cohort of SARS-COV-2 infected individuals outside of Wuhan, China date: 2020-05-22 words: 2861 flesch: 50 summary: The median time between the initial positive RT-PCR test and discharge was significantly longer in asymptomatic COVID-19 patients than in asymptomatic patients with normal chest CT, 13.0 and 10.4 days, respectively (p<0.05; Figure 2 ). Symptomatic COVID-19 patients and asymptomatic cases are both a source of infection and patients in the incubation period can transmit SARS-CoV-2 to other persons keywords: asymptomatic; cases; cov-2; patients; sars cache: cord-294558-cqa58db8.txt plain text: cord-294558-cqa58db8.txt item: #101 of 235 id: cord-294718-n3gx862b author: Tam, Patrick C K title: Detectable severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in human breast milk of a mildly symptomatic patient with coronavirus disease 2019 (COVID-19) date: 2020-05-30 words: 1608 flesch: 52 summary: This case report describes an actively breastfeeding patient with COVID-19 infection with detectable viral RNA in human milk. Given this uncertainty and detectable viral RNA in human milk, the benefits of human milk likely greatly outweigh risks associated with maternal COVID-19 infection, due to conferring protection to other respiratory illnesses [9] . keywords: human cache: cord-294718-n3gx862b.txt plain text: cord-294718-n3gx862b.txt item: #102 of 235 id: cord-294853-8b0s5w4u author: Nolen, Leisha D title: Impact of Social Distancing and Travel Restrictions on non-COVID-19 Respiratory Hospital Admissions in Young Children in Rural Alaska date: 2020-09-05 words: 922 flesch: 37 summary: These data compare ARI hospital admissions during the recent 2019-2020 season with ten preceding seasons in a unique population in rural Alaska with a history of very high rates of respiratory hospitalizations and limited medical accessibility. This demonstrates the potential secondary benefits of implementing social distancing and travel restrictions on respiratory illnesses. keywords: alaska; children; distancing cache: cord-294853-8b0s5w4u.txt plain text: cord-294853-8b0s5w4u.txt item: #103 of 235 id: cord-295270-6ptaxg74 author: Titanji, Boghuma K title: Response to Correspondence: Baricitinib – Impact on COVID-19 Coagulopathy? Jorgensen et. al. date: 2020-08-14 words: 504 flesch: 49 summary: All of the cohort studies of baricitinib for COVID-19 treatment led to significant decline in inflammatory M a n u s c r i p t markers for patients who received the drug 2,3,8 . Drug Saf Baricitinib restrains the immune dysregulation in COVID-19 patients. keywords: covid-19 cache: cord-295270-6ptaxg74.txt plain text: cord-295270-6ptaxg74.txt item: #104 of 235 id: cord-295525-emrwcx0m author: To, Kelvin Kai-Wang title: Consistent Detection of 2019 Novel Coronavirus in Saliva date: 2020-02-12 words: 1944 flesch: 53 summary: There are several advantages in using saliva specimens for the diagnosis of 2019-nCoV. First, saliva specimens can be provided by the patient easily without any invasive procedures. Therefore, the use of saliva specimens could reduce the risk of nosocomial 2019-nCoV transmission. keywords: 2019; coronavirus; ncov; patients; saliva; specimens cache: cord-295525-emrwcx0m.txt plain text: cord-295525-emrwcx0m.txt item: #105 of 235 id: cord-295940-siy32dj7 author: Saito, Makoto title: Gargle lavage as a safe and sensitive alternative to swab samples to diagnose COVID-19: a case report in Japan date: 2020-04-02 words: 535 flesch: 55 summary: Clinical Characteristics of Coronavirus Disease SARS-CoV-2 Viral Load in Upper Respiratory Specimens of Infected Patients Viral load of SARS-CoV-2 in clinical samples Specific primers and probes for detection 2019 novel coronavirus Comparison of gargle samples and throat swab samples for the detection of respiratory pathogens Here we report a case in which gargle lavage samples yielded a positive PCR result. keywords: samples; swabs cache: cord-295940-siy32dj7.txt plain text: cord-295940-siy32dj7.txt item: #106 of 235 id: cord-296588-q2716lda author: Hanson, Kimberly E title: Infectious Diseases Society of America Guidelines on the Diagnosis of COVID-19 date: 2020-06-16 words: 10186 flesch: 40 summary: In addition, the limited data showing poor outcomes in COVID-19 positive patients undergoing a major surgical procedure requiring intubation informed decisions to reduce this risk for asymptomatic patients We also did not identify test accuracy studies directly assessing the performance of SARS-CoV-2 NAATs in asymptomatic individuals. keywords: asymptomatic; c r; cov-2; covid-19; evidence; individuals; p t; patients; s c; sars; studies; test; testing cache: cord-296588-q2716lda.txt plain text: cord-296588-q2716lda.txt item: #107 of 235 id: cord-296631-43z3ee8m author: de Feria, Alejandro title: ACE inhibitors/ARB use and COVID-19. Time to change practice or keep gathering data? date: 2020-07-04 words: 896 flesch: 50 summary: Case series from early on in the pandemic showed that several risk factors including diabetes, coronary artery disease, and hypertension were more common in those suffering with severe forms of COVID-19 disease [1] . Clinical Characteristics of Coronavirus Disease 2019 in China SARS-CoV-2 Cell Entry Depends on ACE2 and TMPRSS2 and Is Blocked by a Clinically Proven Protease Inhibitor Renin-Angiotensin-Aldosterone System Inhibitors and Risk of Covid-19 Cardiovascular Disease, Drug Therapy, and Mortality in Covid-19 Anti-hypertensive Angiotensin II receptor blockers associated to mitigation of disease severity in elderly COVID-19 patients Renin-angiotensin system inhibitors improve the clinical outcomes of COVID-19 patients with hypertension ACE -inhibitors and Angiotensin-2 Receptor Blockers are not associated with severe SARS-COVID19 infection in a multi-site UK acute Hospital Trust Addresses Concerns Re: Using RAAS Antagonists in COVID-19. keywords: covid-19 cache: cord-296631-43z3ee8m.txt plain text: cord-296631-43z3ee8m.txt item: #108 of 235 id: cord-297239-or6h6p9p author: Ridgway, Jessica P. title: Influenza Among Afebrile and Vaccinated Healthcare Workers date: 2015-06-01 words: 2677 flesch: 42 summary: The influence of staff and resident immunization rates on influenza-like illness outbreaks in nursing homes Influenza vaccination of health care workers in long-term-care hospitals reduces the mortality of elderly patients Effect of influenza vaccination of nursing home staff on mortality of residents: a clusterrandomized trial Influenza vaccination of healthcare workers in acute-care hospitals: a case-control study of its effect on hospital-acquired influenza among patients Rapid and sensitive method using multiplex real-time PCR for diagnosis of infections by influenza A and influenza B viruses, respiratory syncytial virus, and parainfluenza viruses 1, 2, 3, and 4 Comparison of the Directigen flu A+B test, the QuickVue influenza test, and clinical case definition to viral culture and reverse transcription-PCR for rapid diagnosis of influenza virus infection Acknowledgments. Influenza in the acute hospital setting Healthcare-associated influenza in Canadian hospitals from Molecular characteristics of outbreaks of nosocomial infection with influenza A/H3N2 virus variants Nosocomial influenza in children Prevention strategies for seasonal influenza in healthcare settings Clinical signs and symptoms predicting influenza infection Viral shedding and clinical illness in naturally acquired influenza virus infections Clinical features of the initial cases of 2009 pandemic influenza A (H1N1) virus infection in China Influenza B in households: virus shedding without symptoms or antibody response The use of personal protective equipment for control of influenza among critical care clinicians: a survey study Efficacy and effectiveness of influenza vaccines: a systematic review and meta-analysis Vaccines for preventing influenza in healthy adults The relative efficacy of trivalent live attenuated and inactivated influenza vaccines in children and adults Evaluation of trivalent, live, coldadapted (CAIV-T) and inactivated (TIV) influenza vaccines in prevention of virus infection and illness following challenge of adults with wild-type influenza A (H1N1), A (H3N2), and B viruses keywords: employees; fever; hcws; influenza; symptoms cache: cord-297239-or6h6p9p.txt plain text: cord-297239-or6h6p9p.txt item: #109 of 235 id: cord-297612-swc2pitd author: Nosyk, Bohdan title: Contact tracing for COVID-19: An opportunity to reduce health disparities and End the HIV/AIDS Epidemic in the US date: 2020-04-27 words: 1639 flesch: 49 summary: We argue that COVID-19 contact tracing may provide a unique opportunity to also conduct widespread HIV testing, among other health promotion activities. COVID-19 contact tracing may provide a unique opportunity to also conduct widespread HIV testing with modified contact tracing that could be acceptable and important for Ending the HIV Epidemic. keywords: contact; covid-19; health; hiv; testing cache: cord-297612-swc2pitd.txt plain text: cord-297612-swc2pitd.txt item: #110 of 235 id: cord-298539-yncda1us author: Ruan, Linhui title: New measures for COVID-19 response: a lesson from the Wenzhou experience date: 2020-04-03 words: 1237 flesch: 44 summary: We expect Wenzhou anti-COVID-19 measures may provide experience for cities around the world that are experiencing this epidemic. Therefore, Wenzhou anti-COVID-19 measures were the extremely rapidly response in COVID-19 crisis. keywords: cities; covid-19; measures; wenzhou cache: cord-298539-yncda1us.txt plain text: cord-298539-yncda1us.txt item: #111 of 235 id: cord-299274-gnbp7so5 author: Bodkin, Claire title: Pandemic Planning in Homeless Shelters: A pilot study of a COVID-19 testing and support program to mitigate the risk of COVID-19 outbreaks in congregate settings date: 2020-06-08 words: 1644 flesch: 48 summary: Furthermore, the higher prevalence of comorbidities amongst shelter residents places them at higher risk of severe COVID-19 disease (5) . No specific limitations were imposed upon shelter residents during the study period although movement between shelters was discouraged. keywords: covid-19; residents; shelter; staff cache: cord-299274-gnbp7so5.txt plain text: cord-299274-gnbp7so5.txt item: #112 of 235 id: cord-299359-s8j78naz author: Sundaram, Maria E. title: Influenza Vaccination Is Not Associated With Detection of Noninfluenza Respiratory Viruses in Seasonal Studies of Influenza Vaccine Effectiveness date: 2013-09-15 words: 3249 flesch: 32 summary: Estimating vaccine effectiveness against laboratory-confirmed influenza using a sentinel physician network: results from the 2005-2006 season of dual A and B vaccine mismatch in Canada Effectiveness of inactivated influenza vaccines varied substantially with antigenic match from the 2004-2005 season to the 2006-2007 season Influenza vaccine effectiveness in Wisconsin during the 2007-08 season: comparison of interim and final results Moderate influenza vaccine effectiveness in I-MOVE: a European network to measure the effectiveness of influenza vaccines Early estimates of seasonal influenza vaccine effectiveness in Europe among target groups for vaccination: results from the I-MOVE multicentre case-control study Increased risk of noninfluenza respiratory virus infections associated with receipt of inactivated influenza vaccine Virus interference and estimates of influenza vaccine effectiveness from test-negative studies The test-negative design for estimating influenza vaccine effectiveness Mortality due to influenza in the United States-an annualized regression approach using multiple-cause mortality data The burden of influenza in children Efficacy and effectiveness of influenza vaccines: a systematic review and meta-analysis Prevention and control of seasonal influenza with vaccines: recommendations of the Advisory Committee on Immunization Practices (ACIP) Centers for Disease Control and Prevention (CDC). The results of this analysis strongly support the validity of case vs test-negative control study designs that are currently used in multiple countries to estimate influenza vaccine effectiveness in the outpatient setting. keywords: children; control; effectiveness; influenza; vaccination; vaccine; virus cache: cord-299359-s8j78naz.txt plain text: cord-299359-s8j78naz.txt item: #113 of 235 id: cord-299499-66qh3r75 author: Guilamo-Ramos, Vincent title: Reconsidering assumptions of adolescent and young adult SARS-CoV-2 transmission dynamics date: 2020-09-07 words: 4203 flesch: 31 summary: Research indicates families-parents, in particular-matter in relation to AYA health behavior [32] . Specific guidance for parents regarding communication and monitoring strategies that positively influence AYA health behavior in the context of COVID-19 is sorely needed. keywords: aya; cov-2; covid-19; health; sars; testing; transmission; years cache: cord-299499-66qh3r75.txt plain text: cord-299499-66qh3r75.txt item: #114 of 235 id: cord-299720-f0ny4ur5 author: Kim, Seung Woo title: Risk Factors for Transmission of Middle East Respiratory Syndrome Coronavirus Infection During the 2015 Outbreak in South Korea date: 2017-03-01 words: 3916 flesch: 45 summary: Spreaders were defined as confirmed cases of MERS-CoV infection that were epidemiologically suspected of transmitting MERS-CoV to 1 or more persons. [15] , which include persons who stayed in a room or ward with a confirmed case, who directly contacted respiratory secretions from confirmed cases, or who stayed within 2 m from the confirmed cases without wearing appropriate personal protective equipment. keywords: cases; cov; infection; mers; outbreak; spreaders; transmission cache: cord-299720-f0ny4ur5.txt plain text: cord-299720-f0ny4ur5.txt item: #115 of 235 id: cord-300013-6m1f4q5r author: Brahier, Thomas title: Lung ultrasonography for risk stratification in patients with COVID-19: a prospective observational cohort study date: 2020-09-17 words: 3250 flesch: 45 summary: Systematic LUS has potential as a reliable, cheap and easy-to-use triage tool for the early risk stratification in COVID-19 patients presenting in EDs The Coronavirus disease pandemic has overwhelmed the health systems in several high-income settings (1) , and is now spreading in the low-income countries. While the majority of COVID-19 patients have a paucisymptomatic or asymptomatic course, some may rapidly deteriorate leading to hospitalisation and the need for respiratory support. keywords: covid-19; lung; lus; patients; score; severity; study cache: cord-300013-6m1f4q5r.txt plain text: cord-300013-6m1f4q5r.txt item: #116 of 235 id: cord-300411-ppcdkfxq author: Xu, Xiao-Ke title: Reconstruction of Transmission Pairs for novel Coronavirus Disease 2019 (COVID-19) in mainland China: Estimation of Super-spreading Events, Serial Interval, and Hazard of Infection date: 2020-06-18 words: 1961 flesch: 43 summary: If , then the infection within households has a higher risk than the infection outside of households for secondary cases of age group b being infected by primary cases of age group a. We estimated the gender-specific hazard of infection for household versus non-household transmissions by the ratio between the probability that a secondary case of gender b was infected by a primary case of gender a within the same household and the probability that a secondary case of gender b was infected by a primary case of gender a via non-household transmission. CONCLUSIONS: Non-negligible frequency of super-spreading events, short serial intervals, and a higher risk of being infected outside of households for male people of working age indicate a significant barrier to the identification and management of COVID-19 cases, which requires enhanced non-pharmaceutical interventions to mitigate this pandemic. keywords: covid-19; household; transmission cache: cord-300411-ppcdkfxq.txt plain text: cord-300411-ppcdkfxq.txt item: #117 of 235 id: cord-300550-l28tadhn author: Luers, Jan C title: Olfactory and Gustatory Dysfunction in Coronavirus Disease 19 (COVID-19) date: 2020-05-01 words: 1756 flesch: 56 summary: Our study shows for the first time that both olfactory and gustatory dysfunction is very common in COVID-19 patients, with olfactory dysfunction even leveling the symptom 'cough' at > 70%. Others often see olfactory dysfunction as a standalone nasal symptom in COVID-19 patients. keywords: covid-19; olfactory; patients cache: cord-300550-l28tadhn.txt plain text: cord-300550-l28tadhn.txt item: #118 of 235 id: cord-301066-62qe4fb0 author: Chiu, Susan S. title: Human Coronavirus NL63 Infection and Other Coronavirus Infections in Children Hospitalized with Acute Respiratory Disease in Hong Kong, China date: 2005-06-15 words: 3958 flesch: 51 summary: A infection is an important cause of febrile seizures Cost-effectiveness of rapid diagnosis of viral respiratory tract infections in pediatric patients Evaluation of the Directigen FluA+B test for rapid diagnosis of influenza virus type A and B infections Rapid diagnosis of a coronavirus associated with severe acute respiratory syndrome (SARS) Identification of a novel coronavirus in patients with severe acute respiratory syndrome Detection of rhinovirus in sinus brushings of patients with acute community-acquired sinusitis by reverse transcription-PCR Frequent detection of human coronaviruses in clinical specimens from patients with respiratory tract infection by use of a novel real-time reverse-transcriptase polymerase chain reaction Coronavirus infection in acute lower respiratory tract disease of infants Epidemiology of coronavirus respiratory infections An outbreak of coronavirus OC43 respiratory infection in Normandy, France Performance of virus isolation and Directigen Flu A to detect influenza A virus in experimental human infection Clinical progression and viral load in a community outbreak of coronavirus-associated SARS pneumonia: a prospective study Coronavirus infections in military recruits: three-year study with coronavirus strains OC43 and 229E The association of viral and bacterial respiratory infections with exacerbations of wheezing in young asthmatic children We thank Bonnie Wong and Chiu Mei Pang, for technical support, and Wilfred H. S. Wong, for statistical analysis. All children admitted to Queen Mary Hospital with signs and symptoms of respiratory infection on one fixed day each week (Tuesday) were included in the study. keywords: children; coronavirus; hcov; infection; nl63; oc43; patients; pcr cache: cord-301066-62qe4fb0.txt plain text: cord-301066-62qe4fb0.txt item: #119 of 235 id: cord-303240-tv1ta3z5 author: Althoff, Keri N title: Contact tracing: Essential to the public health response and our understanding of the epidemiology of COVID-19 date: 2020-06-11 words: 1403 flesch: 50 summary: key: cord-303240-tv1ta3z5 authors: Althoff, Keri N; Coburn, Sally B; Nash, Denis title: Contact tracing: Essential to the public health response and our understanding of the epidemiology of COVID-19 date: 2020-06-11 journal: Clin Infect Dis DOI: 10.1093/cid/ciaa757 sha: doc_id: 303240 cord_uid: tv1ta3z5 nan M a n u s c r i p t As the pandemic in the US continues to evolve, data from contact tracing can continue to inform our understanding about SARS-CoV-2 transmission and guide the public health response. keywords: contact; covid-19; health cache: cord-303240-tv1ta3z5.txt plain text: cord-303240-tv1ta3z5.txt item: #120 of 235 id: cord-303330-zh8wzza5 author: Magleby, Reed title: Impact of SARS-CoV-2 Viral Load on Risk of Intubation and Mortality Among Hospitalized Patients with Coronavirus Disease 2019 date: 2020-06-30 words: 3560 flesch: 42 summary: Identifying high viral load patients could also be helpful for allocating scare therapeutic interventions such as antiviral agents (e.g., remdesivir) Higher viral load was associated with increased age, comorbidities, smoking status, and recent chemotherapy. keywords: cov-2; covid-19; hospital; load; patients; risk; sars cache: cord-303330-zh8wzza5.txt plain text: cord-303330-zh8wzza5.txt item: #121 of 235 id: cord-303603-4mi64bgm author: Martínez-Urbistondo, Diego title: Early Combination of Tocilizumab and Corticosteroids: An Upgrade in Anti-inflammatory Therapy for Severe Coronavirus Disease (COVID) date: 2020-07-04 words: 657 flesch: 34 summary: In this context, the use of anti-inflammatory therapy to treat severe COVID patients has been controversial during the whole pandemics. The results of our cohort may reinforce the early administration of anti-inflammatory therapy published by Fadel et al. keywords: corticosteroids; patients; therapy cache: cord-303603-4mi64bgm.txt plain text: cord-303603-4mi64bgm.txt item: #122 of 235 id: cord-303968-ikr6eeov author: Perinel, Sophie title: Towards Optimization of Hydroxychloroquine Dosing in Intensive Care Unit COVID-19 Patients date: 2020-04-07 words: 1935 flesch: 57 summary: HCQ blood levels were analyzed using a validated liquid chromatography-mass spectrometry method. HCQ was withdrawn in two patients: due to QT interval prolongation (381 to 510 ms and 432 to 550 ms) on day 2 and 3 with HCQ blood levels of 0.03 mg/L and 1.74 mg/L, respectively. keywords: dosing; hcq; levels; patients cache: cord-303968-ikr6eeov.txt plain text: cord-303968-ikr6eeov.txt item: #123 of 235 id: cord-304487-ycvu5l5f author: Wertheim, Joel O title: A glimpse into the origins of genetic diversity in SARS-CoV-2 date: 2020-03-04 words: 1204 flesch: 36 summary: Genetic recombination has biological and evolutionary consequences only when the two recombining viruses are sufficiently genetically distinct. Genomic characterisation and epidemiology of 2019 novel coronavirus: implications for virus origins and receptor binding A pneumonia outbreak associated with a new coronavirus of probable bat origin A case for the ancient origin of coronaviruses Identifying genetic markers of adaptation for surveillance of viral host jumps Evolutionary aspects of recombination in RNA viruses MERS-CoV spillover at the camel-human interface Full-genome evolutionary analysis of the novel corona virus (2019-nCoV) rejects the hypothesis of emergence as a result of a recent recombination event keywords: cov-2; recombination; sars cache: cord-304487-ycvu5l5f.txt plain text: cord-304487-ycvu5l5f.txt item: #124 of 235 id: cord-305394-wwabxlgr author: Venter, W D Francois title: COVID-19: First data from Africa date: 2020-08-31 words: 1471 flesch: 40 summary: Sadly, South Africa has not learnt from other African countries and their epidemics (2) . Key strengths of the paper include a dataset covering over 3 million healthcare users in the Western Cape Province, and the use of both hospitalized and nonhospitalized cases and deaths Davies' data shows similar mortality risk factors, including age, sex, diabetes (especially uncontrolled diabetes), hypertension and renal disease to other cohorts from richer countries. keywords: africa; covid-19; data; hiv; mortality cache: cord-305394-wwabxlgr.txt plain text: cord-305394-wwabxlgr.txt item: #125 of 235 id: cord-306495-o0ah1gj9 author: Haidar, Ghady title: COVID-19, organ transplantation, and the nuances of immunomodulation: lessons learned and what comes next date: 2020-08-11 words: 1264 flesch: 35 summary: Sepsis Cryptococcus neoformans in organ transplant recipients: impact of calcineurin-inhibitor agents on mortality Characteristics of and Important Lessons From the Coronavirus Disease 2019 (COVID-19) Outbreak in China: Additionally, transplant patients frequently suffer from the same comorbidities that have been associated with detrimental outcomes in COVID-19. keywords: covid-19; recipients; sot; transplant cache: cord-306495-o0ah1gj9.txt plain text: cord-306495-o0ah1gj9.txt item: #126 of 235 id: cord-307342-3gkiukh4 author: Clark, Eva title: Why contact tracing efforts have failed to curb COVID-19 transmission in much of the U.S date: 2020-08-06 words: 3274 flesch: 48 summary: key: cord-307342-3gkiukh4 authors: Clark, Eva; Chiao, Elizabeth Y; Amirian, E Susan title: Why contact tracing efforts have failed to curb COVID-19 transmission in much of the U.S date: 2020-08-06 journal: Clin Infect Dis DOI: 10.1093/cid/ciaa1155 sha: doc_id: 307342 cord_uid: 3gkiukh4 By late April 2020, public discourse in the U.S. had shifted toward the idea of using more targeted case-based mitigation tactics (e.g., contact tracing) to combat COVID-19 transmission while allowing for the safe “re-opening” of society, in an effort to reduce the social, economic, and political ramifications associated with stricter approaches. [6] , focusing on expanded testing and contact tracing, while disregarding several major obstacles that set us apart from countries that succeeded in mounting a timely, targeted response. keywords: contact; covid-19; health; public; testing cache: cord-307342-3gkiukh4.txt plain text: cord-307342-3gkiukh4.txt item: #127 of 235 id: cord-307497-wtfvoifb author: Abu-Raya, Bahaa title: Predictors of refractory Coronavirus disease (COVID-19) pneumonia date: 2020-04-09 words: 512 flesch: 16 summary: In addition, refractory COVID-19 patients were more likely to receive oxygen, mechanical ventilation, expectorant, adjunctive treatment including corticosteroids, antiviral drugs and immune enhancers when compared to general COVID-19 patients. Clinical characteristics of refractory COVID-19 pneumonia in Wuhan, China An Easter outbreak of Salmonella Typhimurium DT 104A associated with traditional pork salami in Italy Burden of Children Hospitalized With Pertussis in Canada in the Acellular Pertussis Vaccine Era keywords: covid-19; refractory cache: cord-307497-wtfvoifb.txt plain text: cord-307497-wtfvoifb.txt item: #128 of 235 id: cord-307660-onz6vfre author: Titanji, Boghuma K title: Use of Baricitinib in Patients with Moderate and Severe COVID-19 date: 2020-06-29 words: 1088 flesch: 36 summary: Coronavirus Disease 2019 -Situation report number 148 COVID-19: consider cytokine storm syndromes and immunosuppression Clinical predictors of mortality due to COVID-19 based on an analysis of data of 150 patients from Wuhan, China Baricitinib as potential treatment for 2019-nCoV acute respiratory disease COVID-19: combining antiviral and anti-inflammatory treatments Baricitinib therapy in COVID-19: A pilot study on safety and clinical impact Mechanism of baricitinib supports artificial intelligence-predicted testing in COVID-19 patients IFN-I response timing relative to virus replication determines MERS coronavirus infection outcomes Estimates of the severity of coronavirus disease 2019: a model-based analysis Baricitinib for the treatment of rheumatoid arthritis and systemic lupus erythematosus: a 2019 update THU0211 Meta-analysis of serious infections with baricitinib, tofacitinib and biologic dmards in rheumatoid arthritis In Vitro Antiviral Activity and Projection of Optimized Dosing Design of Hydroxychloroquine for the Treatment of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Vincent Marconi and Raymond F Schinazi are partially funded by -Emory University Center for AIDS Research (AI050409). Severe COVID-19 patients met any of the following criteria; respiratory rate (RR) >30 times/min, oxygen saturation by pulse oximetry 93% at rest or PaO2/FiO2<300 mmHg. keywords: baricitinib; covid-19; disease; patients cache: cord-307660-onz6vfre.txt plain text: cord-307660-onz6vfre.txt item: #129 of 235 id: cord-307770-1igydu3y author: Rawson, Timothy M title: Bacterial and fungal co-infection in individuals with coronavirus: A rapid review to support COVID-19 antimicrobial prescribing date: 2020-05-02 words: 2999 flesch: 34 summary: [42] Procalcitonin has been demonstrated to support differentiation between bacterial and viral infection and supports early cessation of antibiotics in confirmed bacterial infection with no effect on patient mortality. With medication shortages, including key antimicrobials, being a concern across areas currently affected by the pandemic, [45, 46] judicious use of antimicrobials will be vital to ensure access to therapy by those with confirmed bacterial infection. keywords: coronavirus; covid-19; infection; patients; respiratory cache: cord-307770-1igydu3y.txt plain text: cord-307770-1igydu3y.txt item: #130 of 235 id: cord-310390-7pkbd3kg author: Han, Xiaoyu title: Novel Coronavirus Pneumonia (COVID-19) Progression Course in 17 Discharged Patients: Comparison of Clinical and Thin-Section CT Features During Recovery date: 2020-03-30 words: 3178 flesch: 53 summary: When analyzing the evolution of CT findings, the present study had identified three patterns of radiographic progression ( Figure 3 ). When analyzing the evolution of CT finding of all patients by time, the 12 present study found that most patients recovering from COVID-19 showed an initial radiographic deterioration to a peak (mean time, 2 nd week) followed by radiographic improvement in the 3 rd and 4 th week. keywords: clinical; coronavirus; covid-19; improvement; novel; patients; week cache: cord-310390-7pkbd3kg.txt plain text: cord-310390-7pkbd3kg.txt item: #131 of 235 id: cord-310476-mhm7r3qc author: Yi, Huiguang title: 2019 novel coronavirus is undergoing active recombination date: 2020-03-04 words: 746 flesch: 40 summary: 2. Confirmed 2019-nCoV Cases Globally Global Map Real-time, portable genome sequencing for Ebola surveillance Median-joining networks for inferring intraspecific phylogenies Full-feature software for haplotype network construction A Simple and Robust Statistical Test for Detecting the Presence of Recombination Analyzing the mosaic structure of genes PhiPack: PHI test and other tests of recombination nCoV's relationship to bat coronaviruses & recombination signals (no snakes) -no evidence the 2019-nCoV lineage is recombinant Full-genome evolutionary analysis of the novel corona virus (2019-nCoV) rejects the hypothesis of emergence as a result of a recent recombination event Genomic characterisation and epidemiology of 2019 novel coronavirus: implications for virus origins and receptor binding Possible involvement of cell fusion and viral recombination in generation of human immunodeficiency virus variants that display dual resistance to AZT and 3TC Recombination leads to the rapid emergence of HIV-1 dually resistant mutants under selective drug pressure Human immunodeficiency virus superinfection and recombination: current state of knowledge and potential clinical consequences keywords: haplotypes; ncov; recombination cache: cord-310476-mhm7r3qc.txt plain text: cord-310476-mhm7r3qc.txt item: #132 of 235 id: cord-312797-hohzjx74 author: Hamelin, Marie-Ève title: Human Metapneumovirus: A New Player among Respiratory Viruses date: 2004-04-01 words: 3363 flesch: 38 summary: In addition, we found that outbreaks of hMPV infection tend to peak in early spring over a 4-6 week period, slightly later than outbreaks of hRSV infection, which also are more spread out in time [19] . However, additional studies over multiple years are needed to better define the seasonality of hMPV infection. keywords: children; hmpv; hrsv; human; infection; metapneumovirus; studies; tract cache: cord-312797-hohzjx74.txt plain text: cord-312797-hohzjx74.txt item: #133 of 235 id: cord-312905-8xlt92pl author: Li, Guanjian title: Asymptomatic and Presymptomatic Infectors: Hidden Sources of COVID-19 Disease date: 2020-04-09 words: 690 flesch: 44 summary: At the time of writing this paper, the authors claimed that evidence regarding transmission from individuals with asymptomatic infection or mild illness is limited, but that the current evidence may need an update. Their conclusion is that the virus infection rates of close contacts were 6.30% (contact with symptomatic patients) and 4.11% (contact with asymptomatic patients), respectively. keywords: covid-19 cache: cord-312905-8xlt92pl.txt plain text: cord-312905-8xlt92pl.txt item: #134 of 235 id: cord-312928-ef8hqs4s author: Chavanet, Pascal title: Viral Upper Respiratory Tract Infection and Otitis Media Complication in Young Children date: 2008-03-15 words: 591 flesch: 37 summary: Indeed, in this study, the rate of respiratory syncitial virus infection was found to be low, probably as a result of the method used (conventional assays, type of molecular technique, RT-PCR vs. microarray, etc). They found that 63% of children were virus positive and concluded that the rate of otitis media complication was 61% (37% for acute otitis media and 24% for otitis media with effusion), that these risks decrease as the age increases, and that adenovirus, coronavirus, and respiratory syncitial virus represent more than two-thirds of otitis media complications. keywords: children; otitis cache: cord-312928-ef8hqs4s.txt plain text: cord-312928-ef8hqs4s.txt item: #135 of 235 id: cord-313427-6y4zvrmn author: Mani, Nandita S title: Prevalence of COVID-19 Infection and Outcomes Among Symptomatic Healthcare Workers in Seattle, Washington date: 2020-06-16 words: 3434 flesch: 48 summary: We established two high-throughput employee testing centers in Seattle, Washington with drive-through and walk-through options for symptomatic employees in the University of Washington Medicine system and its affiliated organizations. Using data from these testing centers, we report the prevalence of SARS-CoV-2 infection among symptomatic employees and describe the clinical characteristics and outcomes among employees with COVID-19. keywords: cov-2; covid-19; employees; hcws; healthcare; infection; sars; testing cache: cord-313427-6y4zvrmn.txt plain text: cord-313427-6y4zvrmn.txt item: #136 of 235 id: cord-313499-8ijbesl8 author: Stowell, Sean title: Role of serology in the COVID-19 pandemic date: 2020-05-01 words: 1212 flesch: 34 summary: Furthermore, which populations would most benefit from COVID-19 serological testing remains unknown. Serial examination of COVID-19 patients resulted in IgM seroreactivity by day 4 post symptom onset, which peaked by day 9. keywords: covid-19; nat; patients cache: cord-313499-8ijbesl8.txt plain text: cord-313499-8ijbesl8.txt item: #137 of 235 id: cord-313617-hh7lccet author: Sigel, Keith title: Covid-19 and People with HIV Infection: Outcomes for Hospitalized Patients in New York City date: 2020-06-28 words: 2566 flesch: 45 summary: [13] Larger uncontrolled series from New Jersey (13 hospitalized patients), New York City (31 hospitalized patients) and Madrid, Spain (28 hospitalized patients) also subsequently demonstrated COVID-19 outcomes for PWH similar to those described for the general population. We collected data on baseline clinical characteristics, laboratory values, HIV infection status, COVID-19 treatment, and outcomes from this group and matched comparators (one PWH to up to five patients by age, sex, race/ethnicity and calendar week of infection). keywords: covid-19; hiv; pwh cache: cord-313617-hh7lccet.txt plain text: cord-313617-hh7lccet.txt item: #138 of 235 id: cord-313693-qmkrn7pr author: Wong, Bonnie C. K. title: Possible Role of Aerosol Transmission in a Hospital Outbreak of Influenza date: 2010-11-15 words: 4204 flesch: 42 summary: Pandemic (H1N1) Infection prevention and control in health care for confirmed or suspected cases of pandemic (H1N1) 2009 and influenza-like illnesses Interim guidance on infection control measures for 2009 H1N1 influenza in healthcare settings, including protection of healthcare personnel Physical interventions to interrupt or reduce the spread of respiratory viruses: systematic review Surgical mask vs N95 respirator Aerosol Transmission of Influenza • CID 2010:51 (15 November) • 1183 for preventing influenza among health care workers: a randomized trial Novel H1N1 influenza and respiratory protection for health care workers Transmission of influenza A in human beings Evidence of airborne transmission of the severe acute respiratory syndrome virus Temporal-spatial analysis of severe acute respiratory syndrome among hospital inpatients Detection of airborne severe acute respiratory syndrome (SARS) coronavirus and environmental contamination in SARS outbreak units Role of ventilation in airborne transmission of infectious agents in the built environment-a multidisciplinary systematic review Review of aerosol transmission of influenza A virus Aerosol transmission of influenza A virus: a review of new studies Outcomes of adults hospitalized with severe influenza Factors associated with early hospital discharge of adult influenza patients A major outbreak of severe acute respiratory syndrome in Hong Kong Seasonality of influenza A(H3N2) virus: a Hong Kong perspective Lack of cross-immune reactivity against influenza H5N1 from seasonal influenza vaccine in humans Fluent 6.2 user's guide Removal of exhaled particles by ventilation and deposition in a multibed airborne infection isolation room How far droplets can move in indoor environments-revisiting Wells evaporation-falling curve of droplets Exhaled air dispersion distances during noninvasive ventilation via different respironics face masks Noninvasive positive-pressure ventilation: an experimental model to assess air and particle dispersion Exhaled air dispersion during oxygen delivery via a simple oxygen mask The guinea pig as a transmission model for human influenza viruses Transmission of influenza virus via aerosols and fomites in the guinea pig model Transmission and pathogenesis of swine-origin 2009 A(H1N1) influenza viruses in ferrets and mice Measurement of airborne influenza virus in a hospital emergency department Influenza virus in human exhaled breath: an observational study Investigation of a nosocomial outbreak of severe acute respiratory syndrome (SARS) in Toronto, Canada Possible SARS coronavirus transmission during cardiopulmonary resuscitation Why did outbreaks of severe acute respiratory syndrome occur in some hospital wards but not in others? Cross-sectional and longitudinal factors predicting influenza vaccination in Hong Kong Chinese elderly aged 65 and above Willingness of Hong Kong healthcare workers to accept pre-pandemic influenza vaccination at different WHO alert levels: two questionnaire surveys Influenza virus transmission is dependent on relative humidity and temperature Factors involved in the aerosol transmission of infection and control of ventilation in healthcare premises Under natural conditions, influenza virus is transmitted predominantly via droplets and direct contact [13] . keywords: aerosol; air; bay; infection; influenza; outbreak; patients; transmission; virus; ward cache: cord-313693-qmkrn7pr.txt plain text: cord-313693-qmkrn7pr.txt item: #139 of 235 id: cord-314025-h9gj814e author: Lai, Mary Y. Y. title: Survival of Severe Acute Respiratory Syndrome Coronavirus date: 2005-10-01 words: 3094 flesch: 55 summary: First data on stability and resistance of SARS coronavirus compiled by members of WHO laboratory network Diagnostic procedures for viral, rickettsial and chlamydial infections Severe acute respiratory syndrome coronavirus on hospital surfaces Increase in methicillinresistant Staphylococcus aureus acquisition rate and change in pathogen pattern associated with an outbreak of severe acute respiratory syndrome SARS in Hong Kong: from experience to action. More than 20% of the patients with SARS were themselves health care workers, which could be explained by the unique shedding pattern of SARS-CoV, with viral loads reaching a peak ∼2 weeks after onset of disease, when patients were in hospital care keywords: cov; days; gown; paper; sars; stool; virus cache: cord-314025-h9gj814e.txt plain text: cord-314025-h9gj814e.txt item: #140 of 235 id: cord-314489-e5r5s5ee author: Katsidzira, Leolin title: The SARS-CoV-2 epidemic in Zimbabwe: Quo vadis? date: 2020-05-11 words: 1950 flesch: 50 summary: A potential source of higher than anticipated mortality from COVID-19 disease in sub-Saharan Africa is the high burden of HIV infection [5] . Thus, it is reasonable to anticipate a much lower mortality from COVID-19 in sub-Saharan Africa, compared to Europe and North America, where there is a much larger proportion of older people. keywords: africa; covid-19; sars; zimbabwe cache: cord-314489-e5r5s5ee.txt plain text: cord-314489-e5r5s5ee.txt item: #141 of 235 id: cord-315180-itvc86cv author: Hollingsworth, T Déirdre title: Counting Down the 2020 Goals for 9 Neglected Tropical Diseases: What Have We Learned From Quantitative Analysis and Transmission Modeling? date: 2018-06-15 words: 4495 flesch: 38 summary: Similarly, as prevalence falls for MDA diseases, if the right diagnostic becomes available, addressing these diseases could shift to a test-and-treat campaign or even case management. Infectious disease modeling has an increasing role in public-health policy, with resulting challenges and successes [6] . keywords: control; diseases; infection; issue; mda; modeling; ntds; transmission cache: cord-315180-itvc86cv.txt plain text: cord-315180-itvc86cv.txt item: #142 of 235 id: cord-315356-9zf2h0xr author: Apisarnthanarak, Anucha title: Issues Relevant to the Adoption and Modification of Hospital Infection-Control Recommendations for Avian Influenza (H5N1 Infection) in Developing Countries date: 2007-11-15 words: 3005 flesch: 29 summary: Lack of H5N1 avian influenza transmission to hospital employees Avian influenza H5N1 and healthcare workers Seroprevalence of anti-H5 antibody among Thai health care workers after exposure to Avian influenza (H5N1) in a tertiary care center Three Indonesian clusters of H5N1 virus infection in 2005 Fitting characteristics of eighteen N95 filtering-facepiece respirators Headaches and the N95 face-mask amongst healthcare workers Effects of wearing N95 and surgical facemasks on heart rate, thermal stress and subjective sensations The physiological impact of wearing an N95 mask during hemodialysis as a precaution against SARS in patients with endstage renal disease Capturing a killer flu virus Influenza in the acute hospital setting Preparing for pandemic influenza: should hospitals stockpile oseltamivir? In developing countries, health care worker preparedness training should address the modes of avian influenza transmission and specify how to implement appropriate infection-control strategies to prevent and control the spread of avian influenza. keywords: avian; care; control; h5n1; health; infection; influenza; transmission cache: cord-315356-9zf2h0xr.txt plain text: cord-315356-9zf2h0xr.txt item: #143 of 235 id: cord-316970-n2dly3oa author: Kerbaj, Jad title: COVID-19: The New Caledonia experience date: 2020-05-16 words: 1445 flesch: 61 summary: Effective transmission across the globe: the role of climate in COVID-19 mitigation strategies The Effects of Temperature and Relative Humidity on the Viability of the SARS Coronavirus A c c e p t e d M a n u s c r i p The surveillance, quarantine measures, the hospitalization of all detected COVID-19 positive patients and the rapid lockdown had probably an impact on stopping the spread. keywords: sars cache: cord-316970-n2dly3oa.txt plain text: cord-316970-n2dly3oa.txt item: #144 of 235 id: cord-317092-5qba9jiq author: Singh, Tulika title: Lessons from COVID-19 in children: Key hypotheses to guide preventative and therapeutic strategies date: 2020-05-08 words: 4974 flesch: 38 summary: Of the few reports of severe COVID-19 disease in children, all three critical cases had a significant underlying or concurrent medical condition, including acute lymphoblastic leukemia (ALL), hydronephrosis, and intussusception. Specifically, underlying medical issues such as prematurity, chronic lung disease, congenital heart disease, asthma, and even lung injury from vaping and smoking, may result in an increase in the risk for severe COVID-19 disease. keywords: adults; children; coronavirus; cov-2; covid-19; disease; infection; sars cache: cord-317092-5qba9jiq.txt plain text: cord-317092-5qba9jiq.txt item: #145 of 235 id: cord-317823-ztawznod author: Yehya, Nadir title: Statewide Interventions and Covid-19 Mortality in the United States: An Observational Study date: 2020-07-08 words: 3515 flesch: 47 summary: Historical analysis of the 1918-1919 influenza pandemic during the second wave of infections that examined 43 cities in the United States demonstrated an association between earlier school closures and bans on public gatherings with lower mortality Emergency declarations and school closures were two early statewide interventions. keywords: day; emergency; mortality; school; states cache: cord-317823-ztawznod.txt plain text: cord-317823-ztawznod.txt item: #146 of 235 id: cord-317940-yg91bsmm author: Chalumeau, Martin title: Transmission of Panton-Valentine Leukocidin–Producing Staphylococcus aureus to a Physician during Resuscitation of a Child date: 2005-08-01 words: 1049 flesch: 42 summary: key: cord-317940-yg91bsmm authors: Chalumeau, Martin; Bidet, Philippe; Lina, Gérard; Mokhtari, Mostapha; André, Marie-Claude; Gendrel, Dominique; Bingen, Edouard; Raymond, Josette title: Transmission of Panton-Valentine Leukocidin–Producing Staphylococcus aureus to a Physician during Resuscitation of a Child date: 2005-08-01 journal: Clin Infect Dis DOI: 10.1086/431762 sha: doc_id: 317940 cord_uid: yg91bsmm We report the first case of transmission of Panton-Valentine leukocidin–producing Staphylococcus aureus to a physician during the resuscitation of an infant with fatal pneumonia. This case highlights the necessity for health care workers to protect themselves against transmission of infectious diseases from patient to care giver. keywords: aureus; physician; resuscitation; transmission cache: cord-317940-yg91bsmm.txt plain text: cord-317940-yg91bsmm.txt item: #147 of 235 id: cord-317948-svgguadm author: Xiao, Ai Tang title: Profile of RT-PCR for SARS-CoV-2: a preliminary study from 56 COVID-19 patients date: 2020-04-19 words: 1292 flesch: 52 summary: Our study attempted to explore the correlation between clinical characteristics and viral shedding in COVID-19 patients. Prolonged observation period is necessary for older patients. keywords: patients; pcr; sars cache: cord-317948-svgguadm.txt plain text: cord-317948-svgguadm.txt item: #148 of 235 id: cord-318204-t024w7h6 author: Fang, Ferric C title: The Laboratory Diagnosis of COVID-19-- Frequently-Asked Questions date: 2020-06-08 words: 2982 flesch: 34 summary: The role of antibody testing for SARS-CoV-2: Is there one? Severe acute respiratory syndrome coronavirus 2-specific antibody responses in coronavirus disease Test performance evaluation of SARS-CoV-2 serological assays Evaluation of nine commercial SARS-CoV-2 immunoassays Patients with common cold coronavirusaes tested negative for IgG antibody to SARS-CoV-2 Validation and performance comparison of three SARS-CoV-2 antibody assays A systematic review of antibody mediated immunity to coronaviruses: antibody kinetics, correlates of protection, and association of of disease Profiling early humoral response to diagnose novel coronavirus disease (COVID-19) Early detection of SARS-CoV-2 antibodies in COVID-19 patients as a serologic marker of infection Longitudinal change of SARS-Cov2 antibodies in patients with COVID-19 Different longitudinal patterns of nucleic acid and serology testing results based on disease severity of COVID-19 patients COVID-19 and postinfection immunity: Limited Evidence, Many Remaining Questions SARS-CoV-2 infection protects against rechallenge in Rhesus Macaques Convalescent plasma in Covid-19: Possible mechanisms of action Detection of SARS-CoV-2-specific humoral and cellular immunity in COVID-19 convalescent individuals Targets of T cell responses to SARS-CoV-2 coronavirus in humans with COVID-19 disease and unexposed individuals Laboratory diagnosis of emerging human coronavirus infections -the state of the art Point-of-care testing for COVID-19 using SHERLOCK diagnostics Hematologic, biochemical and immune biomarker abnormalities associated with severe illness and mortality in coronavirus disease 2019 (COVID-19): a meta-analysis Elevated levels of IL-6 and CRP predict the need for mechanical ventilation in COVID-19 Interpreting diagnostic tests for SARS-CoV-2 A c c e p t e d M a n u s c r i p t 15 Cross-reactivity between SARS-CoV-1 or MERS-CoV and SARS-CoV-2 is more likely (56) , but should be a limited concern. keywords: cov-2; covid-19; patients; sars cache: cord-318204-t024w7h6.txt plain text: cord-318204-t024w7h6.txt item: #149 of 235 id: cord-318358-glbr8kxh author: Naik, George O A title: COVID-19 and the RAAS date: 2020-06-20 words: 716 flesch: 47 summary: Changes in circulating Ang II concentration alter renin secretion through a negative feedback loop, Figure 1 (a), as Ang II decreases renin secretion increases and consequently affect renin concentration and plasma renin activity (PRA). Ang II changes would also affect aldosterone stimulation and angiotensin IV (Ang IV) production. keywords: ang; renin cache: cord-318358-glbr8kxh.txt plain text: cord-318358-glbr8kxh.txt item: #150 of 235 id: cord-318458-jadk2qbm author: Jung, Chan-Young title: Association between Body Mass Index and Risk of COVID-19: A Nationwide Case-Control Study in South Korea date: 2020-08-25 words: 3660 flesch: 43 summary: In multivariable logistic regression models adjusted for sociodemographic, comorbidity, laboratory and medication data, there was a graded association between higher BMI levels and higher risk of COVID-19 infection; compared to normal weight individuals, the adjusted ORs in the overweight and obese individuals were 1.13 (95% CI, 1.03-1.25) and 1.26 (95% CI, 1.15-1.39), respectively. In logistic regression models that were adjusted for socio-demographic, comorbidity, laboratory and medication data, there was a graded association between higher BMI levels and higher risk of COVID-19 infection (Figure 1 ). keywords: bmi; covid-19; obesity; patients; risk; study cache: cord-318458-jadk2qbm.txt plain text: cord-318458-jadk2qbm.txt item: #151 of 235 id: cord-318615-uhh3owcx author: Xiang, Fei title: Antibody Detection and Dynamic Characteristics in Patients with COVID-19 date: 2020-04-19 words: 2368 flesch: 47 summary: The results from the 60 samples in the control group showed that 3 cases were positive for IgG, while all cases were negative for IgM. To monitor the kinetics of serological antibodies within COVID-19 patients, serological antibodies were tested consecutively once the initiative appearance time of IgM and/or IgG antibody were detected in 29 confirmed patients. We evaluated specificity of IgM and IgG antibodies based on ELISA from 216 serum sample of 85 confirmed COVID-19 pneumonia patients. keywords: antibodies; covid-19; igg; igm; patients; sars cache: cord-318615-uhh3owcx.txt plain text: cord-318615-uhh3owcx.txt item: #152 of 235 id: cord-320562-zvsf3va0 author: Dookie, Navisha title: Tuberculosis Elimination in the Era of COVID-19: A Moving Target date: 2020-09-14 words: 1289 flesch: 43 summary: Firstly, their analysis of TB case notifications between January to May 2020, demonstrates a drastic decrease of 36% and 52% in overall notifications compared to the same period in 2019 and 2015, respectively. This work contributes to the growing global corpus of reports demonstrating a decline in TB case notifications documented during the COVID-19 pandemic [3] . keywords: covid-19; pandemic; tuberculosis cache: cord-320562-zvsf3va0.txt plain text: cord-320562-zvsf3va0.txt item: #153 of 235 id: cord-321603-lbbsnriv author: Rao, Mohan title: Comparing nasopharyngeal swab and early morning saliva for the identification of SARS-CoV-2 date: 2020-08-06 words: 2191 flesch: 51 summary: Moreover, saliva collection is non-invasive, patient friendly and applicable for surveillance testing. that walk-in patients' saliva may not meet the specified standards for saliva collection. keywords: cov-2; detection; saliva; sars; study cache: cord-321603-lbbsnriv.txt plain text: cord-321603-lbbsnriv.txt item: #154 of 235 id: cord-321873-9l9zp6gm author: Zhou, Bo title: The duration of viral shedding of discharged patients with severe COVID-19 date: 2020-04-17 words: 608 flesch: 49 summary: The study was limited to a small number of discharged patients with severe COVID-19, not including mild or moderate infection, because we enrolled patients from the designated hospital for severe COVID-19. c e p t e d M a n u s c r i p t Clinical features of patients infected with 2019 novel coronavirus in Wuhan Epidemiological and clinical characteristics of 99 cases of 2019 novel coronavirus pneumonia in Wuhan, China: a descriptive study Clinical Characteristics of 138 Hospitalized Patients With Novel Coronavirus-Infected Pneumonia in Wuhan New coronavirus pneumonia prevention and control program Clinical course and risk factors for mortality of adult inpatients with COVID-19 in Wuhan, China: a retrospective cohort study Positive RT-PCR Test Results in Patients Recovered From COVID-19 A c c keywords: patients cache: cord-321873-9l9zp6gm.txt plain text: cord-321873-9l9zp6gm.txt item: #155 of 235 id: cord-322082-80ym2rsq author: Monto, Arnold S title: Lessons From Influenza Pandemics of the Last 100 Years date: 2020-03-01 words: 4089 flesch: 41 summary: Influenza viruses were first isolated in the 1930s, and the etiology and timing of previous activity were based on testing of sera from individuals who had lived through the period in question. That tantalizing observation has been used recently to strengthen the suggestion that small-particle aerosol transmission of influenza viruses is of importance. keywords: a(h1n1; human; influenza; mortality; pandemic; vaccine; virus; viruses cache: cord-322082-80ym2rsq.txt plain text: cord-322082-80ym2rsq.txt item: #156 of 235 id: cord-322204-kc7dy2za author: Khalil, Asma title: SARS-CoV-2-specific antibody detection in healthcare workers in a UK maternity Hospital: Correlation with SARS-CoV-2 RT-PCR results date: 2020-08-08 words: 451 flesch: 43 summary: Nasopharyngeal swab polymerase chain reaction (RT-PCR) can diagnose only current or recent infection; testing for antibody responses against SARS-CoV-2 could enhance the ability to expedite reinstatement of services, while ensuring patient and staff safety. Our finding that both of these groups developed SARS-CoV-2 IgG antibodies is reassuring. keywords: sars cache: cord-322204-kc7dy2za.txt plain text: cord-322204-kc7dy2za.txt item: #157 of 235 id: cord-322448-s04e6po9 author: Gadsby, Naomi J. title: Comprehensive Molecular Testing for Respiratory Pathogens in Community-Acquired Pneumonia date: 2016-04-01 words: 4378 flesch: 30 summary: Comprehensive molecular testing of single lower respiratory tract (LRT) specimens achieved pathogen detection in 87% of CAP patients compared with 39% with culture-based methods. One limitation of our study was that it was restricted to CAP patients who could produce a sputum specimen. keywords: bacterial; cap; community; culture; detection; patients; pcr; pneumonia; specimens; time cache: cord-322448-s04e6po9.txt plain text: cord-322448-s04e6po9.txt item: #158 of 235 id: cord-322650-q8inhgtr author: Fung, Yin-Wan Wendy title: Use of Clinical Criteria and Molecular Diagnosis to More Effectively Monitor Patients Recovering after Severe Acute Respiratory Syndrome Coronavirus Infection date: 2004-08-15 words: 1134 flesch: 41 summary: The possible relapse of infection in patient 1 after his transfer to another hospital indeed raises the question of how patients with SARS who have PCR results negative for SARS CoV should be handled [5] . Because SARS is a newly emerging disease that causes serious consequences, many countries have formulated contingency plans for possible future SARS outbreaks. keywords: concentrations; patients; sars; voriconazole cache: cord-322650-q8inhgtr.txt plain text: cord-322650-q8inhgtr.txt item: #159 of 235 id: cord-323125-qtlevnbt author: Al Hosani, Farida Ismail title: Serologic Follow-up of Middle East Respiratory Syndrome Coronavirus Cases and Contacts—Abu Dhabi, United Arab Emirates date: 2019-02-01 words: 3710 flesch: 42 summary: Data collected included demographics; residence/household description; exposure history to other MERS-CoV cases, healthcare settings, and animals; travel history; and medical history, including any long-term effects reported by case patients. Females comprised a higher proportion of case patients compared with household contacts (70.6% vs 53.2%), and case patients were older compared with household contacts (median, 42 years vs 31 years). keywords: case; contacts; coronavirus; cov; household; investigation; mers; patients; respiratory; transmission cache: cord-323125-qtlevnbt.txt plain text: cord-323125-qtlevnbt.txt item: #160 of 235 id: cord-324007-hapzf0fl author: McGeer, Allison J. title: Diagnostic Testing or Empirical Therapy for Patients Hospitalized with Suspected Influenza: What to Do? date: 2009-01-01 words: 2895 flesch: 31 summary: [16] , who demonstrated that hospitalized patients receiving treatment with rimantadine and zanamivir shed influenza virus for several days after hospital admission. Such a policy will have a low risk of adverse events and a low risk of increasing selective pressure for the development of resistant strains of influenza virus. keywords: hospital; influenza; oseltamivir; patients; therapy; treatment cache: cord-324007-hapzf0fl.txt plain text: cord-324007-hapzf0fl.txt item: #161 of 235 id: cord-324307-2zbm4iwn author: Kam, Kai-qian title: A Well Infant With Coronavirus Disease 2019 With High Viral Load date: 2020-02-28 words: 1921 flesch: 57 summary: As the infant had no remaining well caregivers, he was brought to KKH for clinical assessment and isolation in light of his close contact with confirmed COVID-19 cases. A nasopharyngeal specimen taken on admission and tested by rRT-PCR confirmed the diagnosis of COVID-19 infection with low cycle threshold (N gene, 15.57; Orf1ab gene, 13.73), suggesting high viral load. keywords: admission; coronavirus; covid-19; day; infant; sars cache: cord-324307-2zbm4iwn.txt plain text: cord-324307-2zbm4iwn.txt item: #162 of 235 id: cord-324607-rpwccvqi author: Rojek, Amanda M title: Core Minimal Datasets to Advance Clinical Research for Priority Epidemic Diseases date: 2020-02-15 words: 1261 flesch: 29 summary: Among the noteworthy successes of vaccine trials, and the commendable efforts to implement clinical treatment trials during Ebola outbreaks, we should also focus on strengthening the collection and curation of epidemiological and observational data that can improve the conception and design of clinical research. Any diagnostics, drugs, or vaccines that are developed as a result of this and other initiatives, such as the Coalition for Epidemic Preparedness Innovation, will need to be fully evaluated in diagnostic evaluation studies or phase II and III clinical trials. keywords: data; disease; outcome; trial cache: cord-324607-rpwccvqi.txt plain text: cord-324607-rpwccvqi.txt item: #163 of 235 id: cord-324707-9ld73wv1 author: Mitjà, Oriol title: Hydroxychloroquine for Early Treatment of Adults with Mild Covid-19: A Randomized-Controlled Trial date: 2020-07-16 words: 4274 flesch: 47 summary: While WHO has recommended a measure of viral burden in Covid-19 clinical trials, they have neither set up the optimal time for measurement nor the minimal threshold for significant reduction between arms. The added value of our study is the randomized-controlled design and the use of the agreed minimal outcome set for Covid-19 clinical trials, including RT-PCR to conclusively determine the viral burden. keywords: arm; covid-19; days; hcq; hydroxychloroquine; load; patients; study; symptoms; treatment; trial cache: cord-324707-9ld73wv1.txt plain text: cord-324707-9ld73wv1.txt item: #164 of 235 id: cord-325068-j1lfq60o author: Pene, Frédéric title: Coronavirus 229E-Related Pneumonia in Immunocompromised Patients date: 2003-10-01 words: 2586 flesch: 29 summary: Three-year study with coronavirus strains OC43 and 229E Viruses and bacteria in the etiology of the common cold An Outbreak of coronavirus OC43 respiratory infection in Normandy, France Coronavirus as a possible cause of severe acute respiratory syndrome Survival benefit of highdose therapy in poor-risk aggressive non-Hodgkin's lymphoma: final analysis of the prospective LNH87-2 protocol-a groupe d'Etude des lymphomes de l'Adulte study Detection of varicella-zoster virus DNA by polymerase chain reaction in the cerebrospinal fluid of patients suffering from neurological complications associated with chicken pox or herpes zoster Direct diagnosis of human respiratory coronaviruses 229E and OC43 by the polymerase chain reaction Cytomegalovirus: an unexpected cause of ventilator-associated pneumonia Coronavirusrelated nosocomial viral respiratory infections in a neonatal and paediatric intensive care unit: a prospective study Nosocomial adenovirus infection in a paediatric respiratory unit Electron microscopic studies of coronavirus Diagnosis of human coronavirus infection by immunofluorescence: method and application to respiratory disease in hospitalized children Detection of human coronavirus 229E in nasal washings using RNA:RNA hybridisation Occurrence and frequency of coronavirus infections in humans as determined by enzyme-linked immunosorbent assay Mouse hepatitis virus strain JHM infects a human hepatocellular carcinoma cell line Comparison of immunofluorescence with monoclonal antibodies and RT-PCR for the detection of human coronaviruses 229E and OC43 in cell culture Rhinovirus infections in myelosuppressed adult blood and marrow transplant recipients Impact of respiratory virus infections on persons with chronic underlying conditions Rhinovirus infections in hematopoietic stem cell transplant recipients with pneumonia Coronavirus pneumonia following autologous bone marrow transplantation for breast cancer The efficacy and tolerance of intranasal interferons: studies at the Common Cold Unit The role of gamma interferon in infection of susceptible mice with murine coronavirus, MHV-JHM Although chronic underlying conditions are major determinants of severe respiratory virus infections, few data about coronavirus-related pneumonia in immunocompromised patients are available. keywords: 229e; bal; coronavirus; fluid; pcr; pneumonia; specimens cache: cord-325068-j1lfq60o.txt plain text: cord-325068-j1lfq60o.txt item: #165 of 235 id: cord-325136-oyizfh2z author: Pham, Quang Thai title: The first 100 days of SARS-CoV-2 control in Vietnam date: 2020-08-01 words: 2659 flesch: 46 summary: Imported cases were distinguished from those acquired domestically, with information on quarantine at or after entry to the country. Imported cases were denoted G0; and among domestically-acquired infections, those acquired directly from G0 cases were denoted as G1, others were denoted G2+. keywords: cases; control; cov-2; covid-19; measures; sars; vietnam cache: cord-325136-oyizfh2z.txt plain text: cord-325136-oyizfh2z.txt item: #166 of 235 id: cord-325455-e464idc0 author: Atchison, Christina title: Usability and acceptability of home-based self-testing for SARS-CoV-2 antibodies for population surveillance date: 2020-08-12 words: 3280 flesch: 50 summary: Baseline characteristics of study participants are shown in Table 1 . Study participants may not be representative of the general adult population of England. keywords: lfia2; participants; self; study; test; usability cache: cord-325455-e464idc0.txt plain text: cord-325455-e464idc0.txt item: #167 of 235 id: cord-326138-16kpn9db author: Weinstein, Robert A. title: Laboratory-Acquired Infections date: 2009-07-01 words: 3652 flesch: 35 summary: Laboratory infections due to a wide variety of bacteria, viruses, rickettsiae, fungi, and parasites have been described in the literature. In the United States, Brucella infection is one of the most common laboratory-acquired infections, accounting for 24% of laboratory-acquired bacterial infections and 11% of deaths due to laboratory infection keywords: cases; disease; exposure; infections; laboratory; risk; states; united; workers cache: cord-326138-16kpn9db.txt plain text: cord-326138-16kpn9db.txt item: #168 of 235 id: cord-326297-0r9pex1o author: Hartmann, Stacy title: Coronavirus 2019 (COVID-19) Infections Among Healthcare Workers, Los Angeles County, February - May 2020 date: 2020-08-17 words: 2195 flesch: 54 summary: Through May 31 st , 2020, 57,118 confirmed COVID-19 cases in LAC were reported, of which interviews were conducted for approximately 60%. An additional limitation of the data stems from the fact that interviewers were unable to interview approximately 40% of COVID-19 cases; thus, there may be additional HCW cases which have not been identified. keywords: hcws; healthcare; lac cache: cord-326297-0r9pex1o.txt plain text: cord-326297-0r9pex1o.txt item: #169 of 235 id: cord-327069-vjlisnui author: Driscoll, Amanda J. title: Standardization of Laboratory Methods for the PERCH Study date: 2017-06-15 words: 4734 flesch: 38 summary: Site laboratories received uniform training, equipment, and reagents for core testing methods. The standardization of laboratory methods in the PERCH study was equally important to ensure comparability across study sites and for accurate and meaningful interpretation of pneumonia etiology results. keywords: acid; blood; data; laboratory; methods; nucleic; pcr; perch; pneumonia; samples; sites; specimens; study; testing cache: cord-327069-vjlisnui.txt plain text: cord-327069-vjlisnui.txt item: #170 of 235 id: cord-327324-4c4a4bfz author: Wilkinson, Robert J title: Tuberculosis and type 2 Diabetes Mellitus: an inflammatory danger signal in the time of COVID-19 date: 2020-06-13 words: 874 flesch: 30 summary: This theory is Diabetes mellitus increases the risk of active tuberculosis: a systematic review of 13 observational studies Effect of glycemic control and type of diabetes treatment on unsuccessful TB treatment outcomes among people with TB-Diabetes: A systematic review The impact of diabetes on tuberculosis treatment outcomes: a systematic review Diabetes is a strong predictor of mortality during tuberculosis treatment: a prospective cohort study among tuberculosis patients from Mwanza, Tanzania Hyperglycemia during tuberculosis treatment increases morbidity and mortality in a contemporary cohort of HIV-infected patients in Rio de Janeiro, Brazil Stress hyperglycaemia Tuberculosis, HIV and the association with transient hyperglycaemia in peri-urban South Africa Consultation meeting on tuberculosis and diabetes mellitus: meeting summary and recommendations Infections in patients with diabetes mellitus: A review of pathogenesis Immunological mechanisms contributing to the double burden of diabetes and intracellular bacterial infections uninfected African adults using whole blood RNA expression signatures: a casecontrol study HIV-tuberculosis-associated immune reconstitution inflammatory syndrome is characterized by Toll-like receptor and inflammasome signalling Characterization of progressive HIV-associated tuberculosis using 2-deoxy-2-[18F]fluoro-D-glucose positron emission and computed tomography Complement pathway gene activation and rising circulating immune complexes characterize early disease in HIV-associated tuberculosis A modular transcriptional signature identifies phenotypic heterogeneity of human tuberculosis infection OpenSAFELY: factors associated with COVID-19-related hospital death in the linked electronic health records of 17 million adult NHS patients Single-cell landscape of bronchoalveolar immune cells in patients with COVID-19 SARS-CoV-2 receptor ACE2 is an interferon-stimulated gene in human airway epithelial cells and is enriched in specific cell subsets across tissues RJW is supported by the Francis Crick Institute which receives funding from Wellcome (FC0010218), UKRI (FC0010218) and CRUK (FC0010218). It is known that tuberculosis itself associates with transiently impaired glucose tolerance which may even be in the frank diabetic range, yet which may resolve during tuberculosis treatment keywords: diabetes; patients; tuberculosis cache: cord-327324-4c4a4bfz.txt plain text: cord-327324-4c4a4bfz.txt item: #171 of 235 id: cord-327862-zcg3baym author: Luo, Yiqi Ruben title: Kinetics of SARS-CoV-2 Antibody Avidity Maturation and Association with Disease Severity date: 2020-09-14 words: 1144 flesch: 49 summary: t 7 Magnitude and kinetics of anti-SARS-CoV-2 antibody responses and their relationship to disease severity Temporal profiles of viral load in posterior oropharyngeal saliva samples and serum antibody responses during infection by SARS-CoV-2: an observational cohort study Clinical utility of avidity assays Use of antibody avidity assays for diagnosis of severe acute respiratory syndrome coronavirus infection Development of label-free immunoassays as novel solutions for the measurement of monoclonal antibody drugs and antidrug antibodies Antibody Avidity Maturation during Severe Acute Respiratory Syndrome-Associated Coronavirus Infection Antibody avidity, or functional affinity, is a measure of the maturation of the humoral immune response after both infection and vaccination and typically increases over time. keywords: avidity; igg; sars cache: cord-327862-zcg3baym.txt plain text: cord-327862-zcg3baym.txt item: #172 of 235 id: cord-328267-tk0zc8il author: Liu, Qiao title: Collateral Impact of the Covid-19 Pandemic on Tuberculosis Control in Jiangsu Province, China date: 2020-08-28 words: 1668 flesch: 43 summary: Tuberculosis treatment outcomes and diagnostic screening for MDR among tuberculosis patients was also reduced in 2020 indicating that health care access may have reduced or health professionals may have been unavailable in dealing with tuberculosis control after being redirected to Covid-19 control efforts. Our analysis suggests that collateral effects of the Covid-19 pandemic on tuberculosis control are substantial, with a reduction of 36%-52% in tuberculosis notifications in 2020 compared to 2015-2019. keywords: china; control; covid-19; tuberculosis cache: cord-328267-tk0zc8il.txt plain text: cord-328267-tk0zc8il.txt item: #173 of 235 id: cord-328667-r5w09lb6 author: Schwartz, David A title: The Effects of Pregnancy on Women with COVID-19: Maternal and Infant Outcomes date: 2020-05-11 words: 1520 flesch: 38 summary: Africa, DRC Équateur and DR.C Kivu: Four years of excluding pregnant and lactating women and their infants from immunization Viral infection, proliferation and hyperplasia of Hofbauer cells and absence of inflammation characterize the placental pathology of fetuses with congenital Zika virus infection An analysis of 38 pregnant women with COVID-19, their newborn infants, and maternal-fetal transmission of SARS-CoV-2: Maternal coronavirus infections and pregnancy outcomes Clinical characteristics and intrauterine vertical transmission potential of COVID-19 infection in nine pregnant women: a retrospective review of medical records COVID-19 infection among asymptomatic and symptomatic pregnant women: Two weeks of confirmed presentations to an affiliated pair of New York City hospitals Maternal and perinatal outcomes with COVID-19: A systematic review of 108 pregnancies Maternal and neonatal outcomes of pregnant women with COVID-19 pneumonia: a case-control study Infections in pregnancy with COVID-19 and other respiratory RNA virus diseases are rarely, if ever, transmitted to the fetus: In particular, this has been especially true for pregnant women, who fear not only for themselves but often even more so for their unborn infants. keywords: covid-19; disease; infection; women cache: cord-328667-r5w09lb6.txt plain text: cord-328667-r5w09lb6.txt item: #174 of 235 id: cord-329290-vqvujry3 author: Kempker, Russell R title: Loss of Smell and Taste Among Healthcare Personnel Screened for Coronavirus 2019 date: 2020-06-28 words: 1910 flesch: 50 summary: In summary, our findings demonstrate the utility and need for HCP COVID-19 screening and suggest that loss of smell and/or taste be added to symptom screening algorithms. Our aim in this study was to describe the most common and distinguishing clinical symptoms among HCP who underwent screening for COVID-19, with the goal of enhancing future COVID-19 symptom screening efforts. keywords: covid-19; hcp; loss; smell; taste cache: cord-329290-vqvujry3.txt plain text: cord-329290-vqvujry3.txt item: #175 of 235 id: cord-329311-p68kr4ga author: Prebensen, Christian title: SARS-CoV-2 RNA in plasma is associated with ICU admission and mortality in patients hospitalized with COVID-19 date: 2020-09-05 words: 1459 flesch: 52 summary: c e p t e d M a n u s c r i p t Multiorgan and Renal Tropism of SARS-CoV-2 Detection of 2019 novel coronavirus (2019-nCoV) by real-time RT-PCR High frequency of SARS-CoV-2 RNAemia and association with severe disease Impact of neuraminidase inhibitor treatment on outcomes of public health importance during the 2009-2010 influenza A(H1N1) pandemic: a systematic review and meta-analysis in hospitalized patients Impact of SARS-CoV-2 Viral Load on Risk of Intubation and Mortality Among Hospitalized Patients with Coronavirus Disease Viral load dynamics and disease severity in patients infected with SARS-CoV-2 in Zhejiang province, China Correlation of Chest CT and RT-PCR Testing in Coronavirus Disease 2019 (COVID-19) in China: A Report of 1014 Cases Virological assessment of hospitalized patients with COVID-2019 A c c e p t e d In this prospective study of patients hospitalized with COVID-19 we detected SARS-CoV-2 RNAemia in 47% of included patients, and a significantly higher frequency of RNAemia and higher RNA loads in and similarly found that RNAemia was associated with ICU admission and hospital mortality keywords: patients; rna; sars cache: cord-329311-p68kr4ga.txt plain text: cord-329311-p68kr4ga.txt item: #176 of 235 id: cord-329323-1cquorhs author: Ko, Jean Y title: Risk Factors for COVID-19-associated hospitalization: COVID-19-Associated Hospitalization Surveillance Network and Behavioral Risk Factor Surveillance System date: 2020-09-18 words: 4203 flesch: 32 summary: Rate Ratio *Each adjusted model for underlying medical condition includes the select underlying medical condition, age, sex, and race/ethnicity underlying medical condition excludes hypertension to align with 2018 BRFSS community estimates of underlying medical conditions; the most recent year of available BRFSS data for hypertension was As of June 23, 2020, 5,715 adult COVID-19-associated hospitalizations were eligible for inclusion in our analysis; 5,416 adults had underlying medical condition data and were included as hospitalized cases for this study (Figure 1 ). keywords: adults; conditions; covid-19; disease; hospitalization; medical; net; risk cache: cord-329323-1cquorhs.txt plain text: cord-329323-1cquorhs.txt item: #177 of 235 id: cord-330214-28ah3nig author: Zhao, Jiao title: Relationship between the ABO Blood Group and the COVID-19 Susceptibility date: 2020-08-04 words: 1112 flesch: 51 summary: Susceptibility of viral infection has been found to be related to ABO blood group. These results showed associations between ABO blood groups and COVID-19 susceptibility. keywords: blood; covid-19; group cache: cord-330214-28ah3nig.txt plain text: cord-330214-28ah3nig.txt item: #178 of 235 id: cord-330742-m5xx8861 author: Qian, Jie title: Age-dependent gender differences of COVID-19 in mainland China: comparative study date: 2020-05-30 words: 3541 flesch: 53 summary: We used the national surveillance database of COVID-19 in mainland China to compared gender differences in attack rate (AR), proportion of severe and critical cases (PSCC) and case fatality rate (CFR) in relation to age, affected province, and onset-to-diagnosis interval. Furthermore, our findings on gender differences have also provided evidences for addressing the health needs of men and women equally, so as to help policy maker and societies prevent future human tragedies [10, 11] . keywords: age; cases; differences; female; gender; patients cache: cord-330742-m5xx8861.txt plain text: cord-330742-m5xx8861.txt item: #179 of 235 id: cord-330951-k54e3lbu author: Pollett, S title: Social media and the new world of scientific communication during the COVID19 pandemic date: 2020-05-12 words: 815 flesch: 39 summary: Still, Twitter remains the doubleedged sword of rapid scientific communication during the ongoing COVID19 pandemic. key: cord-330951-k54e3lbu authors: Pollett, S; Rivers, C title: Social media and the new world of scientific communication during the COVID19 pandemic date: 2020-05-12 journal: Clin Infect Dis DOI: 10.1093/cid/ciaa553 sha: doc_id: 330951 cord_uid: k54e3lbu The human and social toll of the COVID19 pandemic has already spurred several major public health ‘lessons learned’, and the theme of effective and responsible scientific communication is among them. keywords: communication; twitter cache: cord-330951-k54e3lbu.txt plain text: cord-330951-k54e3lbu.txt item: #180 of 235 id: cord-331465-humpwwk2 author: Canaday, David H title: On setting expectations for a SARS-CoV-2 Vaccine date: 2020-06-04 words: 999 flesch: 36 summary: Potential Conflicts of interest S.G. and D.C. report investigator initiated grants to the university to study influenza vaccines and consulting of flu vaccines from Seqirus, Sanofi-Pasteur, and Pfizer. Past Seasons Vaccine Effectiveness Estimates Polysaccharide conjugate vaccine against pneumococcal pneumonia in adults Effectiveness of the 23-Valent Pneumococcal Polysaccharide Vaccine Pneumococcal Disease in the Elderly: Systematic Review and Meta-Analysis The respiratory syncytial virus vaccine landscape: lessons from the graveyard and promising candidates Influenza Vaccination Modifies Disease Severity Among Community-dwelling Adults Hospitalized With Influenza T cell responses are better correlates of vaccine protection in the elderly Preexisting influenza-specific CD4(+) T cells correlate with disease protection against influenza challenge in humans Cytotoxic T-cell immunity to influenza A phase I trial evaluating the safety and immunogenicity of a candidate tuberculosis vaccination regimen, ChAdOx1 85A prime -MVA85A boost in healthy UK adults mRNA vaccines against H10N8 keywords: influenza; vaccine cache: cord-331465-humpwwk2.txt plain text: cord-331465-humpwwk2.txt item: #181 of 235 id: cord-331719-uijwq8gx author: Russek-Cohen, Estelle title: FDA Perspectives on Diagnostic Device Clinical Studies for Respiratory Infections date: 2011-05-01 words: 4840 flesch: 38 summary: As an aid to sponsors developing new diagnostic devices, FDA posts summaries of the review decisions for cleared devices on the FDA Web site (http://www.accessdata.fda.gov/scripts/cdrh/ cfdocs/cfpmn/pmn.cfm). New devices must be compared with a benchmark for establishing whether or not a specific target condition is present. keywords: device; fda; new; performance; reference; sensitivity; studies; test cache: cord-331719-uijwq8gx.txt plain text: cord-331719-uijwq8gx.txt item: #182 of 235 id: cord-331930-w2055c42 author: Tso, Eugene Y. K. title: Persistence of Physical Symptoms in and Abnormal Laboratory Findings for Survivors of Severe Acute Respiratory Syndrome date: 2004-05-01 words: 530 flesch: 52 summary: Sixty-two patients who experienced the onset of SARS symptoms during the period from 18 March 18 2003 through 30 March 2003 were recruited. The median interval (‫ע‬SD) between the onset of SARS symptoms and the first follow-up visit was weeks. keywords: patients; sars cache: cord-331930-w2055c42.txt plain text: cord-331930-w2055c42.txt item: #183 of 235 id: cord-331978-y4uo7o8g author: Maxwell, Daniel N title: “The Art of War” in the Era of Coronavirus Disease 2019 (COVID-19) date: 2020-03-04 words: 1522 flesch: 49 summary: Their explicit protocols provide a framework for other healthcare and public health systems to weigh along with cost-effectiveness and scalability. As cases of COVID-19 explode internationally, a strategic shift is required away from primarily containment, keeping the virus out there, to home-based mitigation and public health responses. keywords: covid-19; hcw; health; ppe; public cache: cord-331978-y4uo7o8g.txt plain text: cord-331978-y4uo7o8g.txt item: #184 of 235 id: cord-332469-zegawla5 author: Li, Wei title: The characteristics of household transmission of COVID-19 date: 2020-04-17 words: 2514 flesch: 55 summary: Ages of household contacts and spouse relationship with index case are risk factors for transmission of SARS-CoV-2 within household. The median of interval time, from symptomatic onset of index cases to symptomatic onset of household contacts, was 6 days (25th to 75th percentile, 4 to 10). keywords: household; patients; sars cache: cord-332469-zegawla5.txt plain text: cord-332469-zegawla5.txt item: #185 of 235 id: cord-333943-9d93na7s author: Jeong, Han Eol title: Association between NSAIDs use and adverse clinical outcomes among adults hospitalized with COVID-19 in South Korea: A nationwide study date: 2020-07-27 words: 3390 flesch: 37 summary: key: cord-333943-9d93na7s authors: Jeong, Han Eol; Lee, Hyesung; Shin, Hyun Joon; Choe, Young June; Filion, Kristian B; Shin, Ju-Young title: Association between NSAIDs use and adverse clinical outcomes among adults hospitalized with COVID-19 in South Korea: Compared with non-use, NSAIDs use was associated with increased risks of the primary composite outcome (OR 1.54 keywords: covid-19; non; nsaids; use; users cache: cord-333943-9d93na7s.txt plain text: cord-333943-9d93na7s.txt item: #186 of 235 id: cord-335038-q32ghvsv author: Huang, Jiao title: Epidemiological, virological and serological features of COVID-19 cases in people living with HIV in Wuhan City: A population-based cohort study date: 2020-08-17 words: 3174 flesch: 50 summary: The median interval from symptom onset to viral clearance of confirmed COVID-19 cases in PLWH was 30 days in this study, which was longer than that of COVID-19 cases without HIV infection (20 days) key: cord-335038-q32ghvsv authors: Huang, Jiao; Xie, Nianhua; Hu, Xuejiao; Yan, Han; Ding, Jie; Liu, Pulin; Ma, Hongfei; Ruan, Lianguo; Li, Gang; He, Na; Wei, Sheng; Wang, Xia title: Epidemiological, virological and serological features of COVID-19 cases in people living with HIV in Wuhan City: A population-based cohort study date: 2020-08-17 journal: Clin Infect Dis DOI: 10.1093/cid/ciaa1186 sha: doc_id: 335038 cord_uid: q32ghvsv BACKGROUND: We aimed to describe the epidemiological, virological and serological features of coronavirus disease 2019 (COVID-19) cases in people living with HIV (PLWH). keywords: cases; covid-19; hiv; plwh; wuhan cache: cord-335038-q32ghvsv.txt plain text: cord-335038-q32ghvsv.txt item: #187 of 235 id: cord-335691-lsuwsm43 author: Jackson, Michael L. title: The Burden of Community-Acquired Pneumonia in Seniors: Results of a Population-Based Study date: 2004-12-01 words: 3637 flesch: 40 summary: These variables include ischemic cardiac disease, congestive heart failure, chronic obstructive pulmonary disease (COPD), asthma without COPD, renal disease, stroke, dementia, lung cancer, serious nonlung cancer, other cancer, diabetes mellitus, receipt of prednisone, receipt of other immunosuppressive medications, pneumonia hospitalization in the year prior to cohort entry, use of home oxygen, and receipt of home health care. The Community-Based Pneumonia Incidence Study Group Deaths: final data for 1999 Hospitalized community-acquired pneumonia in the elderly: age-and sex-related patterns of care and outcome in the United States Deaths: preliminary data for Effectiveness of pneumococcal polysaccharide vaccine in older adults Vital statistics mortality data, multiple cause detail Update: influenza activity-United States and worldwide, 2000-01 season, and composition of the 2001-02 influenza vaccine Update: influenza activity-United States and worldwide, 1997-98 season, and composition of the 1998-99 influenza vaccine Update: influenza activity-United States and worldwide, 1998-99 season, and composition of the 1999-2000 influenza vaccine Update: influenza activity-United States and worldwide, 1999-2000 season, and composition of the 2000-01 influenza vaccine Time-dependent covariates in the Cox proportionalhazards regression model Epidemiologic methods: studying the occurrence of illness Incidence of communityacquired pneumonia in the population of four municipalities in eastern Finland Clinical efficacy of pneumococcal vaccine in the elderly: a randomized, single-blind populationbased trial Rates of pneumonia during influenza epidemics in Seattle Census 2000 briefs: the 65 years of age and older population Prospective study of pneumonia hospitalizations and mortality of US older people: the role of chronic conditions, health behaviors, and nutritional status Risk factors for community-acquired pneumonia in adults: a population-based case-control study Risk factors for community-acquired pneumonia diagnosed upon hospital admission. keywords: cap; influenza; pneumonia; population; rates; risk; study cache: cord-335691-lsuwsm43.txt plain text: cord-335691-lsuwsm43.txt item: #188 of 235 id: cord-335767-omm04fg5 author: Raabe, Vanessa N title: Importance of Pediatric Inclusion in COVID-19 Therapeutic Trials date: 2020-05-27 words: 1469 flesch: 24 summary: We advocate that pediatric patients should be given equal opportunities to enroll in COVID-19 therapeutic clinical trials and outline our rationale for inclusion of children in our hydroxychloroquine treatment trial. We advocate that COVID-19 therapeutic clinical trials should open enrollment to pediatric patients during these early months of the COVID-19 pandemic according to the bioethical principles of autonomy, beneficence, and justice. keywords: benefit; children; covid-19; trials cache: cord-335767-omm04fg5.txt plain text: cord-335767-omm04fg5.txt item: #189 of 235 id: cord-336563-hwemigk7 author: Bhimraj, Adarsh title: Infectious Diseases Society of America Guidelines on the Treatment and Management of Patients with COVID-19 date: 2020-04-27 words: 8317 flesch: 36 summary: A Randomized Control Trial (THDMS-COVID19) High-Dose Intravenous Immunoglobulin as a Therapeutic Option for Deteriorating Patients With Coronavirus Disease GS-5734 and its parent nucleoside analog inhibit Filo-, Pneumo-, and Paramyxoviruses Broad-spectrum antiviral GS-5734 inhibits both epidemic and zoonotic coronaviruses Therapeutic efficacy of the small molecule GS-5734 against Ebola virus in rhesus monkeys Prophylactic and therapeutic remdesivir (GS-5734) treatment in the rhesus macaque model of MERS-CoV infection Compassionate Use of Remdesivir for Patients with Severe COVID-19 SARS-CoV-2 Cell Entry Depends on ACE2 and TMPRSS2 and Is Blocked by a Clinically Proven Protease Inhibitor Vascular and upper gastrointestinal effects of nonsteroidal anti-inflammatory drugs: meta-analyses of individual participant data from randomised trials Non-steroidal anti-inflammatory drug induced acute kidney injury in the community dwelling general population and people with chronic kidney disease: systematic review and meta-analysis Nonsteroidal antiinflammatory drugs may affect the presentation and course of community-acquired pneumonia Risks Related to the Use of Non-Steroidal Anti-Inflammatory Drugs in Community-Acquired Pneumonia in Adult and Pediatric Patients Efficacy of Addition of Naproxen in the Treatment of Critically Ill Patients Hospitalized for COVID-19 Infection (ENACOVID) HFSA/ACC/AHA statement addresses concerns re: using RAAS antagonists in COVID-19 Treating COVID-19-Off-Label Drug Use, Compassionate Use, and Randomized Clinical Trials During Pandemics Editorial Concern-Possible Reporting of the Same Patients With COVID-19 in Different Reports Steroid therapy and the risk of osteonecrosis in SARS patients: a dose-response meta-analysis The Ebola clinical trials: a precedent for research ethics in disasters Clinical research ethics for critically ill patients: a pandemic proposal Early observational research and registries during the 2009-2010 influenza A pandemic Choosing outcomes for clinical trials: a pragmatic perspective In an open label treatment trial, lopinavir-ritonavir with ribavirin reduced the mortality and requirement of intensive care support of hospitalized SARS patients compared with historical control keywords: clinical; covid-19; disease; evidence; guideline; outcomes; panel; patients; recommendations; risk; sars; studies; treatment; trials; use cache: cord-336563-hwemigk7.txt plain text: cord-336563-hwemigk7.txt item: #190 of 235 id: cord-337972-otfloo64 author: Kao, Shang Jyh title: Mechanism of Fulminant Pulmonary Edema Caused by Enterovirus 71 date: 2004-06-15 words: 1955 flesch: 50 summary: Consent for autopsy of patients who died of acute pulmonary edema was obtained from the patients themselves or from their relatives. The purpose was to elucidate the possible involvement of nitric oxide in the pathogenesis of acute PE associated with enterovirus infection. keywords: infection; patients; pulmonary cache: cord-337972-otfloo64.txt plain text: cord-337972-otfloo64.txt item: #191 of 235 id: cord-338899-qt17jhg0 author: Lakshmi, Vemu title: Clinical Features and Molecular Diagnosis of Chikungunya Fever from South India date: 2008-05-01 words: 3630 flesch: 45 summary: In the present study, the detection of CHIK virus RNA in 48.6% of samples by RT-PCR and in 55.4% of samples by RT-LAMP, as well as the detection of IgM antibodies in 21.5% of samples, confi med that the causative agent of this epidemic was CHIK virus. As is the case for most alphaviruses, detection of CHIK virus depends on isolation of the virus in blood specimens obtained from viremic patients or in infected tissue specimens obtained from blood-feeding arthropods, which are time-consuming. keywords: chik; chikungunya; fever; infection; lamp; patients; pcr; samples; time; virus cache: cord-338899-qt17jhg0.txt plain text: cord-338899-qt17jhg0.txt item: #192 of 235 id: cord-339004-49dkucxd author: Yu, Ignatius Tak-Sun title: Severe Acute Respiratory Syndrome Beyond Amoy Gardens: Completing the Incomplete Legacy date: 2014-03-01 words: 1773 flesch: 47 summary: The peak of the epidemic curve for Amoy Gardens residents occurred on 24-25 March 2003. The proportion of cases with symptom onset during the period 24-29 March was 76.4% (253/331), 55.3% (57/103), and 16.2% (16/99), respectively, for Amoy Gardens residents, residents in the surrounding residential buildings, and residents elsewhere in KT District. keywords: amoy; cases; gardens; sars cache: cord-339004-49dkucxd.txt plain text: cord-339004-49dkucxd.txt item: #193 of 235 id: cord-339859-anatn295 author: Paret, Michal title: SARS-CoV-2 infection (COVID-19) in febrile infants without respiratory distress date: 2020-04-17 words: 1287 flesch: 49 summary: key: cord-339859-anatn295 authors: Paret, Michal; Lighter, Jennifer; Pellett Madan, Rebecca; Raabe, Vanessa N; Shust, Gail F; Ratner, Adam J title: SARS-CoV-2 infection (COVID-19) in febrile infants without respiratory distress date: 2020-04-17 journal: Clin Infect Dis DOI: 10.1093/cid/ciaa452 sha: doc_id: 339859 cord_uid: anatn295 We report two cases of SARS-CoV-2 infection (COVID-19) in infants presenting with fever in the absence of respiratory distress who required hospitalization for evaluation of possible invasive bacterial infections. The diagnoses resulted from routine isolation and real-time RT-PCR-based testing for SARS-CoV-2 for febrile infants in an outbreak setting. keywords: cov-2; infection; sars cache: cord-339859-anatn295.txt plain text: cord-339859-anatn295.txt item: #194 of 235 id: cord-340317-gwqy6u9x author: Dora, Amy V title: Using Serologic Testing to Assess the Effectiveness of Outbreak Control Efforts, Serial PCR Testing, and Cohorting of Positive SARS-CoV-2 Patients in a Skilled Nursing Facility date: 2020-08-28 words: 1600 flesch: 43 summary: To assess unrecognized SARS-CoV-2 exposure, we reviewed serologic testing in a cohort of SNF residents who had been serially tested for SARS-CoV-2 infection by nasopharyngeal swab RT-PCR following a COVID-19 outbreak at this SNF Despite numerous outbreaks, the performance of serologic testing for SARS-CoV-2 in residents of skilled nursing facilities (SNF) is not well described; its utility in epidemiologic sero-surveillance studies and outbreak reporting is under evaluation. keywords: pcr; testing cache: cord-340317-gwqy6u9x.txt plain text: cord-340317-gwqy6u9x.txt item: #195 of 235 id: cord-340579-cvze15cj author: Dudley, Joseph P title: Disparities in Age-Specific Morbidity and Mortality from SARS-CoV-2 in China and the Republic of Korea date: 2020-03-31 words: 1434 flesch: 33 summary: ~0.3% of the ROK population of 51.5 million persons) Data from China exhibit a Gaussian distribution with peak morbidity in the 50-59 years cohort, while the ROK data have a bimodal distribution with highest morbidity in the 20-29 years cohort. keywords: age; cov-2; data; sars cache: cord-340579-cvze15cj.txt plain text: cord-340579-cvze15cj.txt item: #196 of 235 id: cord-340678-2e2s1gof author: Skowronski, Danuta M title: Influenza vaccine does not increase the risk of coronavirus or other non-influenza respiratory viruses: retrospective analysis from Canada, 2010-11 to 2016-17 date: 2020-05-22 words: 1649 flesch: 38 summary: In the context of effective influenza vaccine, influenza cases would have lower likelihood of vaccination; as such, their inclusion would systematically reduce the proportion vaccinated in the control group and thereby inflate ORs comparing vaccine exposure between NIRV cases and controls. Here, we use historic datasets of the community-based Canadian Sentinel Practitioner Surveillance Network (SPSN) to assess the association between influenza vaccine and NIRV risk, notably seasonal coronaviruses. keywords: influenza; nirv; vaccine cache: cord-340678-2e2s1gof.txt plain text: cord-340678-2e2s1gof.txt item: #197 of 235 id: cord-340956-1t3o24u5 author: Borkenhagen, Laura K title: High Risk of Influenza Virus Infection Among Swine Workers: Examining a Dynamic Cohort in China date: 2019-09-01 words: 4192 flesch: 47 summary: The role of swine in the generation of novel influenza viruses Influenza at the animal-human interface: a review of the literature for virological evidence of human infection with swine or avian influenza viruses other than A (H5N1) Weighing serological evidence of human exposure to animal influenza viruses− a literature review Review of influenza A virus in swine worldwide: a call for increased surveillance and research Swine workers and swine influenza virus infections Are swine workers in the United States at increased risk of infection with zoonotic influenza virus? This is similar to results from a longitudinal study of swine workers in Iowa, which found that swine-exposed individuals (OR 54.9, 95% CI 13.0-232.6)-and even their nonexposed spouses (OR 28.2, 95% CI 6.1-130.1)had a higher risk of seroconverting against swine H1N1 virus than other, nonexposed individuals [13] . keywords: cafo; h1n1; h3n2; influenza; participants; seroconversion; swine; virus cache: cord-340956-1t3o24u5.txt plain text: cord-340956-1t3o24u5.txt item: #198 of 235 id: cord-341359-c34gyuv6 author: Larson, Derek T title: Clinical Outcomes of Coronavirus Disease 2019 With Evidence-based Supportive Care date: 2020-05-30 words: 1206 flesch: 35 summary: Notes A pneumonia outbreak associated with a new coronavirus of probable bat origin Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China Clinical features and short-term outcomes of 221 patients with COVID-19 in Wuhan Effectiveness of convalescent plasma therapy in severe COVID-19 patients An epidemiological study on COVID-19: a rapidly spreading disease Characteristics of COVID-19 infection in Beijing The risks of prescribing hydroxychloroquine for treatment of COVID-19-first, do no harm Covid-19-a reminder to reason Acknowledgments. We believe this is attributable to multiple factors, including a focus on supportive care that is well established to benefit patients and a conservative intubation strategy. keywords: care; covid-19; disease; patients cache: cord-341359-c34gyuv6.txt plain text: cord-341359-c34gyuv6.txt item: #199 of 235 id: cord-341435-b36h69r1 author: Dawson, Patrick title: Loss of Taste and Smell as Distinguishing Symptoms of COVID-19 date: 2020-06-21 words: 1693 flesch: 43 summary: This investigation provided an opportunity to identify household COVID-19 cases and describe their symptom profiles, including loss of taste and smell, prior to diagnosis. Nasal congestion alone is unlikely to explain the taste and smell alterations, as one-third of patients reporting loss of taste and/or smell did not report nasal congestion; other analyses have shown an even smaller proportion of COVID-19 cases with concurrent nasal congestion (9) . keywords: covid-19; loss; smell; symptoms; taste cache: cord-341435-b36h69r1.txt plain text: cord-341435-b36h69r1.txt item: #200 of 235 id: cord-341838-lkz8ro90 author: Gervasoni, Cristina title: Clinical features and outcomes of HIV patients with coronavirus disease 2019 date: 2020-05-14 words: 1796 flesch: 43 summary: key: cord-341838-lkz8ro90 authors: Gervasoni, Cristina; Meraviglia, Paola; Riva, Agostino; Giacomelli, Andrea; Oreni, Letizia; Minisci, Davide; Atzori, Chiara; Ridolfo, Annalisa; Cattaneo, Dario title: Clinical features and outcomes of HIV patients with coronavirus disease 2019 date: 2020-05-14 journal: Clin Infect Dis DOI: 10.1093/cid/ciaa579 sha: doc_id: 341838 cord_uid: lkz8ro90 Little is known about the clinical outcomes of HIV patients infected with SARS-CoV-2. [5] [6] [7] Treated people living with HIV who have a normal CD4 T cell count and suppressed viral load may not be at increased risk of serious illness, but many also have other conditions that increase their overall risk: almost half of HIV patients are males, aged >50 years, and affected by chronic cardiovascular and lung diseases. keywords: hiv; patients; sars cache: cord-341838-lkz8ro90.txt plain text: cord-341838-lkz8ro90.txt item: #201 of 235 id: cord-343827-jo61t3m0 author: Qian, Qun title: Direct evidence of active SARS-CoV-2 replication in the intestine date: 2020-07-08 words: 1319 flesch: 38 summary: Notably, coincidence with rectal tissues of surgical specimens tested nucleic acid positive for SARS-CoV-2, typical coronavirus virions in rectal tissue were observed under electron microscopy. Immunohistochemical analysis and immunofluorescence were carried out on rectal tissues to evaluate the distribution of SARS-CoV-2 antigen, and immune cell infiltrations. keywords: coronavirus; cov-2; patient; sars cache: cord-343827-jo61t3m0.txt plain text: cord-343827-jo61t3m0.txt item: #202 of 235 id: cord-344038-20n74z3o author: Han, Mi Seon title: Sequential analysis of viral load in a neonate and her mother infected with SARS-CoV-2 date: 2020-04-16 words: 1553 flesch: 60 summary: Currently, only three descriptive studies on neonates with COVID-19 have been reported, and to our knowledge, none have investigated viral dynamics in infected neonates As COVID-19 cases surge, the number of children with COVID-19 is also on the increase. keywords: cov-2; covid-19; neonate; sars cache: cord-344038-20n74z3o.txt plain text: cord-344038-20n74z3o.txt item: #203 of 235 id: cord-345045-nlui9d6e author: Zahn, Matthew title: Infectious Diseases Physicians: Improving and Protecting the Public’s Health: Why Equitable Compensation Is Critical date: 2019-07-15 words: 3574 flesch: 32 summary: Here, we examine compensation data for ID physicians compared to their value in population and public health settings and suggest policy recommendations to address the pay disparities that exist between cognitive and procedural specialties that prevent more medical students and residents from entering the field. ID physicians do more than protect the health of their patients. keywords: control; diseases; health; healthcare; infections; outbreak; physicians; prevention; public cache: cord-345045-nlui9d6e.txt plain text: cord-345045-nlui9d6e.txt item: #204 of 235 id: cord-346502-x2b0ao3q author: Arabi, Yaseen M title: Ribavirin and Interferon Therapy for Critically Ill Patients With Middle East Respiratory Syndrome: A Multicenter Observational Study date: 2019-06-25 words: 4095 flesch: 41 summary: Crude 90-day mortality was higher in patients who received RBV/rIFN therapy compared to those who did not Analyses of RBV therapy vs no RBV and rIFN vs no rIFN were consistent with results to the primary analysis, with no significant association with 90-day mortality or MERS-CoV RNA clearance using marginal structural modeling (Table 4 ). The objective of this study was to examine the effect of RBV/ rIFN therapy in a large cohort of critically ill patients with MERS on the 90-day mortality and MERS-CoV RNA clearance by accounting for baseline and time-varying confounders. keywords: cov; day; mers; mortality; patients; rbv; rifn; therapy; time cache: cord-346502-x2b0ao3q.txt plain text: cord-346502-x2b0ao3q.txt item: #205 of 235 id: cord-348036-yub2cqz6 author: Lighter, Jennifer title: Obesity in patients younger than 60 years is a risk factor for Covid-19 hospital admission date: 2020-04-09 words: 725 flesch: 52 summary: t Dear Editor, Risk factors for infectious disease severity are determined by the pathogen, host and environment Recognition of risk factors for morbidity and mortality is important to determine prevention strategies as well as to target high-risk populations for potential therapeutics. keywords: bmi; patients cache: cord-348036-yub2cqz6.txt plain text: cord-348036-yub2cqz6.txt item: #206 of 235 id: cord-348144-t0chpsuh author: Lucas, Alexander H. title: Carbohydrate Moieties as Vaccine Candidates date: 2005-09-01 words: 5574 flesch: 24 summary: PS antigens, by nature of their multivalent, repeating glycotope structure, engage a sufficient number of B cell receptors that result in B cell activation and maturation to antibody secretion. It is likely that bacteria, purified PS, and glycoconjugate vaccines address overlapping as well as distinct subsets of B cells. keywords: antibody; antigens; capsular; carbohydrate; cells; conjugate; glycotopes; polysaccharide; protein; response; type; vaccine cache: cord-348144-t0chpsuh.txt plain text: cord-348144-t0chpsuh.txt item: #207 of 235 id: cord-348178-6bjimde4 author: Li, Ling title: Biosafety Level 3 Laboratory for Autopsies of Patients with Severe Acute Respiratory Syndrome: Principles, Practices, and Prospects date: 2005-09-15 words: 3690 flesch: 49 summary: Therefore, autopsies involving SARS autopsies may be considered more dangerous than are autopsies involving more common biohazard group 3 organisms, such as Mycobacterium tuberculosis. First, use of a BSL-3 ventilation system is the prerequisite for SARS autopsies. keywords: air; area; autopsies; autopsy; gas; laboratory; ppe; sars; system cache: cord-348178-6bjimde4.txt plain text: cord-348178-6bjimde4.txt item: #208 of 235 id: cord-348350-pac9ha4q author: Martin-Blondel, G title: Hydroxychloroquine in COVID-19 patients: what still needs to be known about the kinetics date: 2020-05-11 words: 1827 flesch: 48 summary: Moreover, monitoring hydroxychloroquine concentrations in bronchoalveolar fluids of COVID-19 patients could provide additional information on the degree of hydroxychloroquine lung impregnation [9, 10] for a short period of treatment (i.e. few days). The concentrations measured in COVID-19 patients show that hydroxychloroquine exposure tends to be low and in most instances lower than the values reported in SLE patients, in particular for the standard regimen of 200 mg x 3/day. keywords: day; hydroxychloroquine; patients cache: cord-348350-pac9ha4q.txt plain text: cord-348350-pac9ha4q.txt item: #209 of 235 id: cord-348392-e35cd9sg author: Moraleda, Cinta title: Multi-Inflammatory Syndrome in Children related to SARS-CoV-2 in Spain date: 2020-07-25 words: 1762 flesch: 59 summary: [Sp]=100%), n=4; Immunochemoluminescence Diasorin TM SARS-CoV-2 S1/S2 IgG, S=97%, E=98%, n=1; ELISA in-house total antibody test, included within Solidarity II trial, ongoing and results pending, n=6; Rapid Test BioZek TM , IgM (S=85%, Sp=96%), IgG (S=99.9%, Sp=88%), n=3; Immunoassays Elecsys SARS-CoV-2 Cobas TM , total antibodies, S=84%, Sp=100%, n=2. key: cord-348392-e35cd9sg authors: Moraleda, Cinta; Serna-Pascual, Miquel; Soriano-Arandes, Antoni; Simó, Silvia; Epalza, Cristina; Santos, Mar; Grasa, Carlos; Rodríguez, Maria; Soto, Beatriz; Gallego, Nerea; Ruiz, Yolanda; Urretavizcaya-Martínez, María; Pareja, Marta; Sanz-Santaeufemia, Francisco José; Fumadó, Victoria; Lanaspa, Miguel; Jordan, Iolanda; Prieto, Luis; Belda, Sylvia; Toral-Vázquez, Belén; Rincón, Elena; Gil-Villanueva, Nuria; Méndez-Echevarría, Ana; Castillo-Serrano, Ana; Rivière, Jacques G; Soler-Palacín, Pere; Rojo, Pablo; Tagarro, Alfredo title: Multi-Inflammatory Syndrome in Children related to SARS-CoV-2 in Spain date: 2020-07-25 journal: Clin Infect Dis DOI: 10.1093/cid/ciaa1042 sha: doc_id: 348392 cord_uid: e35cd9sg Some clusters of children with a multisystem inflammatory syndrome associated with SARS-CoV-2 infection (MIS-C) have been reported. keywords: cov-2; sars cache: cord-348392-e35cd9sg.txt plain text: cord-348392-e35cd9sg.txt item: #210 of 235 id: cord-348478-ho89o8mj author: Pawlotsky, Jean-Michel title: SARS-CoV-2 pandemic : Time to revive the cyclophilin inhibitor alisporivir date: 2020-05-15 words: 2102 flesch: 40 summary: A reveal its essential role for human coronavirus 229E replication Feline coronavirus replication is affected by both cyclophilin A and cyclophilin B The SARS-coronavirus-host interactome: identification of cyclophilins as target for pan-coronavirus inhibitors Function of HAb18G/CD147 in invasion of host cells by severe acute respiratory syndrome coronavirus Cyclophilins and cyclophilin inhibitors in nidovirus replication Suppression of feline coronavirus replication in vitro by NL63 replication is cyclophilin A-dependent and inhibited by non-immunosuppressive cyclosporine Aderivatives including alisporivir Nucleocapsid protein of SARS coronavirus tightly binds to human cyclophilin A Genetic deficiency and polymorphisms of cyclophilin keywords: alisporivir; coronavirus; cov; cyclophilin; sars cache: cord-348478-ho89o8mj.txt plain text: cord-348478-ho89o8mj.txt item: #211 of 235 id: cord-349070-bqv03u2e author: Jiang, Shih Sheng title: Sensitive and Quantitative Detection of Severe Acute Respiratory Syndrome Coronavirus Infection by Real-Time Nested Polymerase Chain Reaction date: 2004-01-15 words: 2476 flesch: 44 summary: To reduce the risk of random or carry-over contamination of nested PCR [10] , sample preparation, reagent preparation, and PCR amplification were performed in different buildings or rooms with separated air-conditioning using different sets of the pipette system. This dual real-time PCR method can be easily completed within 2 h using LightCycler, which includes a 45-min, 1-step RT-PCR followed by 40-min real-time nested PCR, making it an ideal routine protocol for high-throughput screening of SARS-CoV. Second, the assay had a detection limit of !10 copies of SARS-CoV, to reduce the rate of false-negative results for trace virus samples. keywords: assay; detection; pcr; rna; round; sars; time cache: cord-349070-bqv03u2e.txt plain text: cord-349070-bqv03u2e.txt item: #212 of 235 id: cord-349556-k312qkvh author: Roldán-Santiago, Ernesto title: SARS-CoV-2 spreads to lymph nodes and strongly expands CD4+ T(EMRA) cells in a patient with mild COVID-19 date: 2020-09-18 words: 1836 flesch: 54 summary: Lymphopenia predicts disease severity of COVID-19: a descriptive and predictive study Radiological findings from 81 patients with COVID-19 pneumonia in Wuhan, China: a descriptive study The novel severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) directly decimates human spleens and lymph nodes for the Modena Covid-19 Working Group SARS-CoV-2, the virus that causes COVID-19: cytometry and the new challenge for global health Distribution and compartmentalization of human circulating and tissue-resident memory T cells subsets Characterization of the CD4 T cell response to Epstein-Barr virus during primary and persistent Infection Tonsilar homing of Epstein-Barr virus-specific CD8+ T cells and the virus-host balance Human CD4+ memory T-cells are preferential targets for bystander activation and apoptosis Breadth of concomitant responses prior to patient recovery: a case report of non-severe COVID-19 Baseline pulmonary levels of CD8+ T cells and NK cells inversely correlate with expression of the SARS-CoV-2 entry receptor ACE2 Unique phenotypes and clonal expansions of human CD4 effector memory T cells re-expressing CD45RA However, as mentioned previously, we observed a large increase in the percentage of CD4+ T EMRA cells in LN, a cell subset virtually absent in LN from healthy 7 or infected individuals, including EBV infection. keywords: cells; cov-2; sars cache: cord-349556-k312qkvh.txt plain text: cord-349556-k312qkvh.txt item: #213 of 235 id: cord-349566-zx9kt144 author: de Alencar, Julio Cesar Garcia title: Double-blind, randomized, placebo-controlled trial with N-acetylcysteine for treatment of severe acute respiratory syndrome caused by COVID-19 date: 2020-09-23 words: 2959 flesch: 48 summary: We hypothesized that N-acetylcysteine (NAC) administration could restore this redox homeostasis and suppress unfavorable evolution in Covid-19 patients. It is necessary, therefore, to discuss the causes of this treatment failure in improving respiratory function in Covid-19 patients. keywords: angii; angiotensin; covid-19; nac; patients; placebo; redox cache: cord-349566-zx9kt144.txt plain text: cord-349566-zx9kt144.txt item: #214 of 235 id: cord-350338-lcsa06gm author: Wang, Kun title: Clinical and laboratory predictors of in-hospital mortality in patients with COVID-19: a cohort study in Wuhan, China date: 2020-05-03 words: 2475 flesch: 45 summary: The MuLBSTA Score Genomic characterisation and epidemiology of 2019 novel coronavirus: implications for virus origins and receptor binding From gene to proteinexperimental and clinical studies of ACE2 in blood pressure control and arterial hypertension Preparing for the next influenza pandemic An interferon-γ-related cytokine storm in SARS patients Corticosteroid Treatment Ameliorates Acute Lung Injury Induced by 2009 Swine Origin Influenza A (H1N1) Virus in Mice The trafficking protein JFC1 regulates Rac1-GTP localization at the uropod controlling neutrophil chemotaxis and in vivo migration Understanding the T cell immune response in SARS coronavirus infection Biochemical Aspects of Coronavirus Replication and Virus-Host Interaction Abnormal Coagulation parameters are associated with poor prognosis in patients with novel coronavirus pneumonia Specific ACE2 Expression in Cholangiocytes Nowcasting and forecasting the potential domestic and international spread of the 2019-nCoV outbreak originating in Wuhan, China: a modelling study Epidemiological and clinical characteristics of 99 cases of 2019 novel coronavirus pneumonia in Wuhan, China: a descriptive study Clinical features of patients infected with 2019 novel coronavirus in Wuhan Clinical Characteristics of 138 Hospitalized Patients With 2019 Novel Coronavirus-Infected Pneumonia in Wuhan, China A familial cluster of pneumonia associated with the 2019 novel coronavirus indicating person-to-person transmission: a study of a family cluster Machine learning for the prediction of volume responsiveness in patients with oliguric acute kidney injury in critical care Boosted tree model reforms multimodal magnetic resonance imaging infarct prediction in acute stroke Transparent Reporting of a Multivariable Prediction Model for Individual Prognosis or Diagnosis (TRIPOD) Comparing the areas under two or more correlated receiver operating characteristic curves: a nonparametric approach Innate immune responses in the ageing lung Clinical Features Predicting Mortality Risk in Patients With Viral Pneumonia: keywords: clinical; cohort; covid-19; hospital; model; patients; study cache: cord-350338-lcsa06gm.txt plain text: cord-350338-lcsa06gm.txt item: #215 of 235 id: cord-350686-q2bu7o4i author: Bilder, Christopher R title: Pool size selection when testing for SARS-CoV-2 date: 2020-06-16 words: 540 flesch: 63 summary: In general, the probability of a negative pool ( ) is given by = (1 -) for a prevalence ( ) and pool size ( ) [5] . Similar inefficiencies occur as well when selecting pool sizes that are too small. keywords: pool; testing cache: cord-350686-q2bu7o4i.txt plain text: cord-350686-q2bu7o4i.txt item: #216 of 235 id: cord-350972-0n4dumgg author: Sing, Chor-Wing title: Long-term outcome of short-course high-dose glucocorticoids for SARS: a 17-year follow-up in SARS survivors date: 2020-07-16 words: 1793 flesch: 52 summary: The association between high-dose glucocorticoids and AVN in SARS patients has been reported. To understand the long-term consequences of VHD glucocorticoids, we studied the clinical outcomes of SARS survivors after 17 years. keywords: glucocorticoids; patients; sars; study; use cache: cord-350972-0n4dumgg.txt plain text: cord-350972-0n4dumgg.txt item: #217 of 235 id: cord-351231-aoz5jbf1 author: Bartlett, John G. title: Why Infectious Diseases date: 2014-09-15 words: 5512 flesch: 38 summary: So it is with the discipline of infectious diseases. As with all medical specialties, infectious diseases has unique features that are important to highlight: Among medical specialties, this one is consistently changing, often unpredictable, usually exciting, and incredibly rewarding for health impact. keywords: antibiotics; cases; disease; health; infection; influenza; medicine; new; patient; resistance; states; united; use; virus cache: cord-351231-aoz5jbf1.txt plain text: cord-351231-aoz5jbf1.txt item: #218 of 235 id: cord-351314-atsuh8e2 author: Bryson-Cahn, Chloe title: A Novel Approach for a Novel Pathogen: using a home assessment team to evaluate patients for 2019 novel coronavirus (SARS-CoV-2) date: 2020-03-12 words: 1259 flesch: 37 summary: Given concerns with healthcare exposures and healthcare-associated outbreaks with SARS-CoV-2, as well as historical experiences with SARS-CoV and MERS-CoV transmission in healthcare settings, minimizing the exposure risk to clinics, emergency departments, and hospitals is crucial. In a clinically stable patient with mild symptoms, alternative methods for special pathogen evaluation/testing are vital to preserve healthcare resources and prevent unnecessary exposures. keywords: cov-2; healthcare; patients; sars cache: cord-351314-atsuh8e2.txt plain text: cord-351314-atsuh8e2.txt item: #219 of 235 id: cord-351348-lzo0dz7z author: Gu, Silan title: Alterations of the Gut Microbiota in Patients with COVID-19 or H1N1 Influenza date: 2020-06-04 words: 1996 flesch: 42 summary: This cross-sectional study analyzed the gut microbiome of COVID-19 patients, H1N1 patients, and healthy controls (HC) by high-throughput sequencing of the 16S rRNA gene to provide a theoretical basis for differential diagnosis and intestinal microbial intervention. Patients with H1N1 displayed lower diversity and different overall microbial composition compared with COVID-19 patients. keywords: covid-19; gut; h1n1; patients cache: cord-351348-lzo0dz7z.txt plain text: cord-351348-lzo0dz7z.txt item: #220 of 235 id: cord-351589-32kd9vva author: Mang, Sebastian title: Pneumocystis Jirovecii Pneumonia and SARS-CoV-2 Co-Infection in newly diagnosed HIV-1 infection date: 2020-07-01 words: 563 flesch: 50 summary: For evaluation of pulmonary COVID-19 manifestation and in preparation for possible ECMO, computed tomography (CT) was performed on 13 th and 14 th May. Radiological findings from 81 patients with COVID-19 pneumonia in Wuhan, China: a descriptive study. keywords: covid-19 cache: cord-351589-32kd9vva.txt plain text: cord-351589-32kd9vva.txt item: #221 of 235 id: cord-352837-a29d5dkv author: Hirsch, Hans H title: Spatiotemporal Virus Surveillance for Severe Acute Respiratory Infections in Resource-limited Settings: How Deep Need We Go? date: 2019-04-01 words: 1999 flesch: 22 summary: Redefining chronic viral infection Translational aspects of the human respiratory virome A new arenavirus in a cluster of fatal transplant-associated diseases Identification of a novel polyomavirus in a pancreatic transplant recipient with retinal blindness and vasculitic myopathy The human gut virome: inter-individual variation and dynamic response to diet Intestinal domination and the risk of bacteremia in patients undergoing allogeneic hematopoietic stem cell transplantation Temporal response of the human virome to immunosuppression and antiviral therapy Full-length haplotype reconstruction to infer the structure of heterogeneous virus populations Evaluation of unbiased next-generation sequencing of RNA (RNA-seq) as a diagnostic method in influenza virus-positive respiratory samples Global burden of acute lower respiratory infections due to respiratory syncytial virus in young children: a systematic review and meta-analysis Mortality associated with influenza and respiratory syncytial virus in the United States Global mortality estimates for the 2009 influenza pandemic from the GLaMOR project: a modeling study Comparing viral respiratory tract infections in symptomatic children and adults: multiplex NAT from 2010-2015 Comparing Luminex NxTAG-respiratory pathogen panel and RespiFinder-22 for multiplex detection of respiratory pathogens Community-acquired respiratory paramyxovirus infection after allogeneic hematopoietic cell transplantation: a single-center experience Comprehensive diagnostics for respiratory virus infections after transplantation or after potential exposure to swine flu A/H1N1: what else is out there? High incidence of active cytomegalovirus infection among septic patients Sepsis and cytomegalovirus: foes or conspirators? Viral impact on long-term kidney graft function Human cytomegalovirus: clinical aspects, immune regulation, and emerging treatments BK virus: opportunity makes a pathogen Reactivation of multiple viruses in patients with sepsis Torque teno virus in children who underwent orthotopic liver transplantation: new insights about a common pathogen Viral infection in acute exacerbation of idiopathic pulmonary fibrosis The evolution of seasonal influenza viruses Taken together, this report from resource-limiting settings is also of relevance for resource-rich countries and raises the question about how to best expand current first-or second-line testing for respiratory viral pathogens including CMV, parvovirus B19, and measles, and how to move to more deep sequencing virome analysis and comprehensive metagenomics in the near future. keywords: cases; human; respiratory; sari; sequencing; virus cache: cord-352837-a29d5dkv.txt plain text: cord-352837-a29d5dkv.txt item: #222 of 235 id: cord-352899-bt2xg0ha author: Van Kerkhove, Maria D. title: Interpreting Results From Environmental Contamination Studies of Middle East Respiratory Syndrome Coronavirus date: 2016-10-15 words: 805 flesch: 33 summary: Maria D. Van Kerkhove, 1,2 Malik J. S. Peiris, 3 Mamunur Rahman Malik, 4 and Peter Ben Embarek 2 Middle East respiratory syndrome coronavirus (MERS-CoV): current situation 3 years after the virus was first identified Preliminary epidemiological assessment of MERS-CoV outbreak in South Korea Notes from the field: nosocomial outbreak of Middle East respiratory syndrome in a large tertiary care hospital-Riyadh Extensive viable Middle East respiratory syndrome (MERS) coronavirus contamination in air and surrounding environment in MERS outbreak units Environmental contamination and viral shedding in MERS patients during MERS-CoV outbreak in South Korea Stability of Middle East respiratory syndrome coronavirus (MERS-CoV) under different environmental conditions Environmental contamination and viral shedding in MERS patients Middle East respiratory syndrome coronavirus (MERS-CoV) [3] , but the role of environmental contamination has received relatively little attention. keywords: contamination; cov; mers cache: cord-352899-bt2xg0ha.txt plain text: cord-352899-bt2xg0ha.txt item: #223 of 235 id: cord-353103-sdij1d90 author: Yao, Xueting title: In Vitro Antiviral Activity and Projection of Optimized Dosing Design of Hydroxychloroquine for the Treatment of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) date: 2020-03-09 words: 3455 flesch: 49 summary: In this study we aimed to: (i) investigate the antiviral and prophylactic activity of hydroxychloroquine and chloroquine in vitro, (ii) build a PBPK model for hydroxychloroquine and chloroquine using data from literature, and, (iii) predict drug concentrations under different dosing regimens using the developed PBPK models. Using the PBPK models, hydroxychloroquine concentrations in lung fluid were simulated under 5 different dosing regimens to explore the most effective regimen whilst considering the drug’s safety profile. keywords: data; drug; hydroxychloroquine; lung; pbpk; sars; study; vitro cache: cord-353103-sdij1d90.txt plain text: cord-353103-sdij1d90.txt item: #224 of 235 id: cord-353116-7t1prfkr author: Bhargava, Ashish title: Predictors for Severe COVID-19 Infection date: 2020-05-30 words: 2636 flesch: 50 summary: Predictors for severe COVID-19 infection have not been well defined. Severe COVID-19 infection was noted in 74 (37.6%) patients, requiring intubation. keywords: covid-19; crp; disease; infection; patients; risk cache: cord-353116-7t1prfkr.txt plain text: cord-353116-7t1prfkr.txt item: #225 of 235 id: cord-353342-2n6kqyeo author: Corman, Victor M. title: Viral Shedding and Antibody Response in 37 Patients With Middle East Respiratory Syndrome Coronavirus Infection date: 2016-02-15 words: 4051 flesch: 50 summary: WHO/MERS/RA/15 MERS-CoV outbreak in Jeddah-a link to health care facilities An observational, laboratory-based study of outbreaks of Middle East respiratory syndrome coronavirus in Jeddah and Riyadh, Kingdom of Saudi Arabia Preliminary epidemiological assessment of MERS-CoV outbreak in South Korea The aetiology, origins, and diagnosis of severe acute respiratory syndrome Detection of a novel human coronavirus by real-time reverse-transcription polymerase chain reaction Assays for laboratory confirmation of novel human coronavirus (hCoV-EMC) infections Infectious Middle East respiratory syndrome coronavirus excretion and serotype variability based on live virus isolates from patients in Saudi Arabia Dipeptidyl peptidase 4 is a functional receptor for the emerging human coronavirus-EMC Transmission of MERS-coronavirus in household contacts Presence of Middle East respiratory syndrome coronavirus antibodies in Saudi Arabia: a nationwide, cross-sectional, serological study Antibodies against MERS coronavirus in dromedary camels Middle East respiratory syndrome Respiratory tract samples, viral load, and genome fraction yield in patients with Middle East respiratory syndrome Evaluation of advanced reverse transcription-PCR assays and an alternative PCR target region for detection of severe acute respiratory syndrome-associated coronavirus Detection of SARS coronavirus in patients with severe acute respiratory syndrome by conventional and real-time quantitative reverse transcription-PCR assays The epidemiology of severe acute respiratory syndrome in the 2003 Hong Kong epidemic: an analysis of all 1755 patients Detection of SARS coronavirus in patients with suspected SARS Clinical progression and viral load in a community outbreak of coronavirus-associated SARS pneumonia: a prospective study Efficient replication of the novel human betacoronavirus EMC on primary human epithelium highlights its zoonotic potential Detection of SARS coronavirus in plasma by real-time RT-PCR Quantitative analysis and prognostic implication of SARS coronavirus RNA in the plasma and serum of patients with severe acute respiratory syndrome Detection of severe acute respiratory syndrome coronavirus RNA in plasma during the course of infection Multiple organ infection and the pathogenesis of SARS Chemokine up-regulation in SARS-coronavirus-infected, monocyte-derived human dendritic cells SARS-coronavirus replicates in mononuclear cells of peripheral blood (PBMCs) from SARS patients SARS-coronavirus replication in human peripheral monocytes/macrophages Acute renal impairment in coronavirusassociated severe acute respiratory syndrome Enteric involvement of severe acute respiratory syndrome-associated coronavirus infection Contact investigation of a case of human novel coronavirus infection treated in a German hospital Acknowledgments. As in SARS, kidney failure in MERS patients might well be explained by severe inflammatory reaction combined with the administration of potentially nephrotoxic drugs during intensive care keywords: cases; coronavirus; cov; mers; patients; rna; samples; sars; syndrome cache: cord-353342-2n6kqyeo.txt plain text: cord-353342-2n6kqyeo.txt item: #226 of 235 id: cord-353862-7xe3fvd5 author: Li, Na title: Maternal and neonatal outcomes of pregnant women with COVID-19 pneumonia: a case-control study date: 2020-03-30 words: 3518 flesch: 49 summary: However, previous studies argued that false negative cases might be common for COVID-19 infection cases due to low virus titers, sampling at late stage of illness, and This rate was higher than in suspected patients (16.7%) and in two control groups (~5%) of our study, but lower than the rate of 44% in confirmed COVID-19 pneumonia patients reported by Chen et al. keywords: cases; covid-19; delivery; patients; pneumonia; sars; women cache: cord-353862-7xe3fvd5.txt plain text: cord-353862-7xe3fvd5.txt item: #227 of 235 id: cord-354009-1ek4s8oe author: Wang, Yun title: Spatiotemporal Characteristics of COVID-19 Epidemic in the United States date: 2020-07-08 words: 3145 flesch: 51 summary: We obtained county-based counts of COVID-19 cases confirmed in the United States from January 22 to May 13, 2020 (N=1,386,050). We obtained the counts of COVID-19 cases diagnosed from January 22 to May 13, 2020 in the United States from the USAFacts, a not-for-profit initiative standardizing and providing the government record-based data publicly available. keywords: areas; cases; counties; covid-19; epi; incidence cache: cord-354009-1ek4s8oe.txt plain text: cord-354009-1ek4s8oe.txt item: #228 of 235 id: cord-354011-v9t2b2ca author: Benkouiten, Samir title: Circulation of Respiratory Viruses Among Pilgrims During the 2012 Hajj Pilgrimage date: 2013-10-01 words: 3759 flesch: 46 summary: Applicability of a real-time quantitative PCR assay for diagnosis of respiratory syncytial virus infection in immunocompromised adults Real-time reverse transcriptase PCR assay for detection of human metapneumoviruses from all known genetic lineages Real-time reverse transcription-PCR assay for comprehensive detection of human rhinoviruses Pring-Akerblom P. Rapid and quantitative detection of human adenovirus DNA by real-time PCR A retrospective overview of enterovirus infection diagnosis and molecular epidemiology in the public hospitals of Marseille RNA and DNA bacteriophages as molecular diagnosis controls in clinical virology: a comprehensive study of more than 45 000 routine PCR tests Influenza and respiratory syncytial virus infections in British Hajj pilgrims Viral respiratory infections at the Hajj: comparison between UK and Saudi pilgrims Detection of respiratory viruses among pilgrims in Saudi Arabia during the time of a declared influenza A(H1N1) pandemic Viral etiology of acute respiratory infections among Iranian Hajj pilgrims Influenza vaccine in Hajj pilgrims: policy issues from field studies Influenza viral infections among the Iranian Hajj pilgrims returning to Shiraz, Fars province Pandemic 2009 influenza A (H1N1) infection among 2009 Hajj pilgrims from southern Iran: a real-time RT-PCR-based study Human rhinoviruses Clinical effects of rhinovirus infections Pathogenesis of rhinovirus infection Transmission of rhinovirus colds by self-inoculation Aerosol transmission of rhinovirus colds A randomized trial of the efficacy of hand disinfection for prevention of rhinovirus infection Lack of nasal carriage of novel corona virus (HCoV-EMC) in French Hajj pilgrims returning from the Hajj 2012, despite a high rate of respiratory symptoms Travel reported by pilgrims from Marseille Evaluation of PCR testing of ethanol-fixed nasal swab specimens as an augmented surveillance strategy for influenza virus and adenovirus identification The viral etiology of an influenza-like illness during the 2009 pandemic Bacteria and viruses that cause respiratory tract infections during the pilgrimage (Haj) season in Makkah, Saudi Arabia key: cord-354011-v9t2b2ca authors: Benkouiten, Samir; Charrel, Rémi; Belhouchat, Khadidja; Drali, Tassadit; Salez, Nicolas; Nougairede, Antoine; Zandotti, Christine; Memish, Ziad A.; al Masri, Malak; Gaillard, Catherine; Parola, Philippe; Brouqui, Philippe; Gautret, Philippe title: Circulation of Respiratory Viruses Among Pilgrims During the 2012 Hajj Pilgrimage date: 2013-10-01 journal: Clin Infect Dis DOI: 10.1093/cid/cit446 sha: doc_id: 354011 cord_uid: v9t2b2ca Background. keywords: hajj; hrv; influenza; ksa; pilgrims; respiratory; symptoms; viruses cache: cord-354011-v9t2b2ca.txt plain text: cord-354011-v9t2b2ca.txt item: #229 of 235 id: cord-354265-udt2spoe author: Gersh, Felice title: Menopause status and COVID-19 date: 2020-09-23 words: 582 flesch: 32 summary: (8) Given the potential for serious negative effects ensuing from a state of estradiol deficiency, heightened by the COVID-19 pandemic, not only should appropriate postmenopausal women be considered for hormone replacement therapy, but women being treated with aromatase inhibitors and estrogen receptor antagonists should be counseled on the risks and benefits of those drugs, personalized in each case, in light of the findings of this study. (7) The use of hormone replacement therapy gains further support from this excellent study. keywords: women cache: cord-354265-udt2spoe.txt plain text: cord-354265-udt2spoe.txt item: #230 of 235 id: cord-354877-n5du3bqt author: Vasoo, Shawn title: Rapid Antigen Tests for Diagnosis of Pandemic (Swine) Influenza A/H1N1 date: 2009-10-01 words: 1785 flesch: 40 summary: Rapid influenza antigen tests (point-of-care tests) might prove useful, because they have a fast turnaround time (10-15 min) and require minimal training to perform. However, there are few data on the diagnostic accuracy of rapid influenza antigen tests for pandemic influenza A/H1N1 virus [6] . keywords: antigen; h1n1; influenza; tests; virus cache: cord-354877-n5du3bqt.txt plain text: cord-354877-n5du3bqt.txt item: #231 of 235 id: cord-354943-wxhbwcfr author: Guo, Li title: Profiling Early Humoral Response to Diagnose Novel Coronavirus Disease (COVID-19) date: 2020-03-21 words: 3497 flesch: 52 summary: To evaluate the potential cross-reactivities of N proteins between SARS-CoV-2 and other human coronaviruses, we examined the reactivities of the SARS-CoV-2 rNP and human plasma with positive antibodies against NL63, 229E, OC43, HKU1, and SARS-CoV, respectively, by using Western blot and ELISA assays. Novel coronavirus (2019-nCoV) early-stage importation risk to Europe Summary of probable SARS cases with onset of illness from 1 Acknowledgments. keywords: coronavirus; cov-2; days; detection; igm; patients; samples; sars cache: cord-354943-wxhbwcfr.txt plain text: cord-354943-wxhbwcfr.txt item: #232 of 235 id: cord-355618-7kfxc2w1 author: McAteer, John title: The VACCINES Act, Deciphering Vaccine Hesitancy in the Time of COVID19 date: 2020-04-13 words: 1894 flesch: 41 summary: Despite remarkable advances in vaccine science, vaccine hesitancy has now become a recognized public health threat with potentially disastrous complications. To address vaccine hesitancy, we need to reframe our approach and focus on understanding the root causes of this complicated problem. keywords: hesitancy; immunization; states; vaccine cache: cord-355618-7kfxc2w1.txt plain text: cord-355618-7kfxc2w1.txt item: #233 of 235 id: cord-355734-pz64534w author: Antonio-Villa, Neftali Eduardo title: Health-care workers with COVID-19 living in Mexico City: clinical characterization and related outcomes date: 2020-09-28 words: 3267 flesch: 38 summary: First, we analyzed a large dataset which included information on confirmed positive and negative SARS-CoV-2 cases in Mexico City, providing a unique opportunity to investigate COVID-19 specific risk factors in HCWs. In this work, we report the prevalence of SARS-CoV-2 infection, related symptomatology, and COVID-19 clinical outcomes using a city-wide based surveillance reports of HCWs living in Mexico City. keywords: cases; cov-2; covid-19; hcws; outcomes; risk; sars cache: cord-355734-pz64534w.txt plain text: cord-355734-pz64534w.txt item: #234 of 235 id: cord-356084-621qzpqd author: Qu, Jiuxin title: Profile of IgG and IgM antibodies against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) date: 2020-04-27 words: 1579 flesch: 51 summary: [9] , and we detected high levels of IgG antibody in critical patients. Delayed, but stronger antibody responses were observed in critical patients. keywords: igg; igm; patients; sars cache: cord-356084-621qzpqd.txt plain text: cord-356084-621qzpqd.txt item: #235 of 235 id: cord-356316-ui11jr2h author: Patel, Monita R title: Performance of oropharyngeal swab testing compared to nasopharyngeal swab testing for diagnosis of COVID-19 —United States, January-February 2020 date: 2020-06-16 words: 1184 flesch: 48 summary: NP swab was selected as the comparator because during the testing timeframe, NP swab was the preferred upper respiratory specimen per CDC Guidelines; however, OP swab was an acceptable alternative specimen for diagnostic testing (independent of NP swab testing/result) However, NP swab Ct values were lower (indicating more virus) in 66.7% of concordant-positive pairs, suggesting NP swabs may more accurately detect amount of SARS-CoV-2. keywords: swab cache: cord-356316-ui11jr2h.txt plain text: cord-356316-ui11jr2h.txt