id	sid	tid	token	lemma	pos
clinmedi-179	1	1	cmi	cmi	PROPN
clinmedi-179	1	2	04	04	NUM
clinmedi-179	1	3	(	(	PUNCT
clinmedi-179	1	4	02	02	NUM
clinmedi-179	1	5	)	)	PUNCT
clinmedi-179	1	6	,	,	PUNCT
clinmedi-179	1	7	378−386	378−386	NUM
clinmedi-179	1	8	cmi	cmi	PROPN
clinmedi-179	1	9	journal	journal	NOUN
clinmedi-179	1	10	378	378	NUM
clinmedi-179	1	11	clinical	clinical	ADJ
clinmedi-179	1	12	medicine	medicine	NOUN
clinmedi-179	1	13	insights	insight	NOUN
clinmedi-179	1	14	doi	doi	NOUN
clinmedi-179	1	15	:	:	PUNCT
clinmedi-179	1	16	https://doi.org/10.52845	https://doi.org/10.52845	ADJ
clinmedi-179	1	17	/	/	SYM
clinmedi-179	1	18	cmi/2023	cmi/2023	NOUN
clinmedi-179	1	19	-	-	PUNCT
clinmedi-179	1	20	4	4	NUM
clinmedi-179	1	21	-	-	PUNCT
clinmedi-179	1	22	2	2	NUM
clinmedi-179	1	23	-	-	SYM
clinmedi-179	1	24	1	1	NUM
clinmedi-179	1	25	cmi	cmi	NOUN
clinmedi-179	1	26	04	04	NUM
clinmedi-179	1	27	(	(	PUNCT
clinmedi-179	1	28	02	02	NUM
clinmedi-179	1	29	)	)	PUNCT
clinmedi-179	1	30	,	,	PUNCT
clinmedi-179	1	31	378	378	NUM
clinmedi-179	1	32	-	-	SYM
clinmedi-179	1	33	386	386	NUM
clinmedi-179	1	34	(	(	PUNCT
clinmedi-179	1	35	2023	2023	NUM
clinmedi-179	1	36	)	)	PUNCT
clinmedi-179	1	37	issn	issn	PROPN
clinmedi-179	1	38	(	(	PUNCT
clinmedi-179	1	39	o	o	NOUN
clinmedi-179	1	40	)	)	PUNCT
clinmedi-179	1	41	2694	2694	NUM
clinmedi-179	1	42	-	-	SYM
clinmedi-179	1	43	4626	4626	NUM
clinmedi-179	1	44	research	research	NOUN
clinmedi-179	1	45	article	article	NOUN
clinmedi-179	1	46	efficacy	efficacy	NOUN
clinmedi-179	1	47	and	and	CCONJ
clinmedi-179	1	48	safety	safety	NOUN
clinmedi-179	1	49	of	of	ADP
clinmedi-179	1	50	neoadjuvant	neoadjuvant	ADJ
clinmedi-179	1	51	chemotherapy	chemotherapy	NOUN
clinmedi-179	1	52	with	with	ADP
clinmedi-179	1	53	dose	dose	PROPN
clinmedi-179	1	54	de	de	PROPN
clinmedi-179	1	55	-	-	NOUN
clinmedi-179	1	56	escalation	escalation	ADJ
clinmedi-179	1	57	tri	tri	ADJ
clinmedi-179	1	58	-	-	ADJ
clinmedi-179	1	59	weekly	weekly	ADJ
clinmedi-179	1	60	nanoparticle	nanoparticle	NOUN
clinmedi-179	1	61	albumin	albumin	NOUN
clinmedi-179	1	62	-	-	PUNCT
clinmedi-179	1	63	bound	bind	VERB
clinmedi-179	1	64	paclitaxel	paclitaxel	NOUN
clinmedi-179	1	65	and	and	CCONJ
clinmedi-179	1	66	fec	fec	PROPN
clinmedi-179	1	67	for	for	ADP
clinmedi-179	1	68	human	human	ADJ
clinmedi-179	1	69	epidermal	epidermal	ADJ
clinmedi-179	1	70	growth	growth	NOUN
clinmedi-179	1	71	factor	factor	NOUN
clinmedi-179	1	72	receptor	receptor	NOUN
clinmedi-179	1	73	2	2	NUM
clinmedi-179	1	74	-	-	PUNCT
clinmedi-179	1	75	positive	positive	ADJ
clinmedi-179	1	76	breast	breast	NOUN
clinmedi-179	1	77	cancer	cancer	NOUN
clinmedi-179	1	78	kazumi	kazumi	PROPN
clinmedi-179	1	79	kawase	kawase	PROPN
clinmedi-179	1	80	1	1	NUM
clinmedi-179	1	81	,	,	PUNCT
clinmedi-179	1	82	*	*	PUNCT
clinmedi-179	1	83	,	,	PUNCT
clinmedi-179	1	84	kazuhiko	kazuhiko	PROPN
clinmedi-179	1	85	yoshida	yoshida	PROPN
clinmedi-179	1	86	1	1	NUM
clinmedi-179	1	87	,	,	PUNCT
clinmedi-179	1	88	keigo	keigo	ADJ
clinmedi-179	1	89	hara	hara	PROPN
clinmedi-179	1	90	1	1	NUM
clinmedi-179	1	91	,	,	PUNCT
clinmedi-179	1	92	suguru	suguru	NOUN
clinmedi-179	1	93	hidaka	hidaka	ADJ
clinmedi-179	1	94	1	1	NUM
clinmedi-179	1	95	,	,	PUNCT
clinmedi-179	1	96	and	and	CCONJ
clinmedi-179	1	97	hiroshi	hiroshi	PROPN
clinmedi-179	1	98	takeyama	takeyama	NOUN
clinmedi-179	1	99	2	2	NUM
clinmedi-179	1	100	1	1	NUM
clinmedi-179	1	101	department	department	NOUN
clinmedi-179	1	102	of	of	ADP
clinmedi-179	1	103	surgery	surgery	NOUN
clinmedi-179	1	104	,	,	PUNCT
clinmedi-179	1	105	the	the	DET
clinmedi-179	1	106	jikei	jikei	NOUN
clinmedi-179	1	107	university	university	PROPN
clinmedi-179	1	108	school	school	NOUN
clinmedi-179	1	109	of	of	ADP
clinmedi-179	1	110	medicine	medicine	NOUN
clinmedi-179	1	111	katsushika	katsushika	PROPN
clinmedi-179	1	112	medical	medical	PROPN
clinmedi-179	1	113	center	center	PROPN
clinmedi-179	1	114	,	,	PUNCT
clinmedi-179	1	115	tokyo	tokyo	PROPN
clinmedi-179	1	116	,	,	PUNCT
clinmedi-179	1	117	japan	japan	PROPN
clinmedi-179	1	118	2	2	NUM
clinmedi-179	1	119	department	department	NOUN
clinmedi-179	1	120	of	of	ADP
clinmedi-179	1	121	surgery	surgery	NOUN
clinmedi-179	1	122	,	,	PUNCT
clinmedi-179	1	123	the	the	DET
clinmedi-179	1	124	jikei	jikei	NOUN
clinmedi-179	1	125	university	university	PROPN
clinmedi-179	1	126	school	school	NOUN
clinmedi-179	1	127	of	of	ADP
clinmedi-179	1	128	medicine	medicine	NOUN
clinmedi-179	1	129	,	,	PUNCT
clinmedi-179	1	130	tokyo	tokyo	PROPN
clinmedi-179	1	131	,	,	PUNCT
clinmedi-179	1	132	japan	japan	PROPN
clinmedi-179	1	133	*	*	PUNCT
clinmedi-179	1	134	corresponding	correspond	VERB
clinmedi-179	1	135	author	author	NOUN
clinmedi-179	1	136	:	:	PUNCT
clinmedi-179	1	137	kazumi	kazumi	PROPN
clinmedi-179	1	138	kawase	kawase	PROPN
clinmedi-179	1	139	introduction	introduction	NOUN
clinmedi-179	1	140	neoadjuvant	neoadjuvant	ADJ
clinmedi-179	1	141	chemotherapy	chemotherapy	NOUN
clinmedi-179	1	142	(	(	PUNCT
clinmedi-179	1	143	nac	nac	PROPN
clinmedi-179	1	144	)	)	PUNCT
clinmedi-179	1	145	is	be	AUX
clinmedi-179	1	146	the	the	DET
clinmedi-179	1	147	standard	standard	ADJ
clinmedi-179	1	148	treatment	treatment	NOUN
clinmedi-179	1	149	for	for	ADP
clinmedi-179	1	150	early	early	ADJ
clinmedi-179	1	151	and	and	CCONJ
clinmedi-179	1	152	locally	locally	ADV
clinmedi-179	1	153	advanced	advanced	ADJ
clinmedi-179	1	154	breast	breast	NOUN
clinmedi-179	1	155	cancer	cancer	NOUN
clinmedi-179	1	156	because	because	SCONJ
clinmedi-179	1	157	it	it	PRON
clinmedi-179	1	158	enables	enable	VERB
clinmedi-179	1	159	less	less	ADV
clinmedi-179	1	160	extensive	extensive	ADJ
clinmedi-179	1	161	surgery	surgery	NOUN
clinmedi-179	1	162	and	and	CCONJ
clinmedi-179	1	163	provides	provide	VERB
clinmedi-179	1	164	information	information	NOUN
clinmedi-179	1	165	on	on	ADP
clinmedi-179	1	166	treatment	treatment	NOUN
clinmedi-179	1	167	effects	effect	NOUN
clinmedi-179	1	168	.	.	PUNCT
clinmedi-179	2	1	currently	currently	ADV
clinmedi-179	2	2	,	,	PUNCT
clinmedi-179	2	3	the	the	DET
clinmedi-179	2	4	standard	standard	ADJ
clinmedi-179	2	5	treatment	treatment	NOUN
clinmedi-179	2	6	for	for	ADP
clinmedi-179	2	7	breast	breast	NOUN
clinmedi-179	2	8	cancer	cancer	NOUN
clinmedi-179	2	9	is	be	AUX
clinmedi-179	2	10	nac	nac	NOUN
clinmedi-179	2	11	consisting	consisting	NOUN
clinmedi-179	2	12	of	of	ADP
clinmedi-179	2	13	an	an	DET
clinmedi-179	2	14	anthracycline	anthracycline	NOUN
clinmedi-179	2	15	and	and	CCONJ
clinmedi-179	2	16	taxanebased	taxanebased	ADJ
clinmedi-179	2	17	regimens	regimen	NOUN
clinmedi-179	2	18	.	.	PUNCT
clinmedi-179	3	1	the	the	DET
clinmedi-179	3	2	most	most	ADV
clinmedi-179	3	3	frequently	frequently	ADV
clinmedi-179	3	4	used	use	VERB
clinmedi-179	3	5	drugs	drug	NOUN
clinmedi-179	3	6	are	be	AUX
clinmedi-179	3	7	the	the	DET
clinmedi-179	3	8	solvent	solvent	NOUN
clinmedi-179	3	9	-	-	PUNCT
clinmedi-179	3	10	based	base	VERB
clinmedi-179	3	11	paclitaxel	paclitaxel	PROPN
clinmedi-179	3	12	(	(	PUNCT
clinmedi-179	3	13	sb	sb	NOUN
clinmedi-179	3	14	-	-	ADJ
clinmedi-179	3	15	ptx	ptx	NOUN
clinmedi-179	3	16	)	)	PUNCT
clinmedi-179	3	17	and	and	CCONJ
clinmedi-179	3	18	abstract	abstract	ADJ
clinmedi-179	3	19	introduction	introduction	NOUN
clinmedi-179	3	20	:	:	PUNCT
clinmedi-179	3	21	neoadjuvant	neoadjuvant	ADJ
clinmedi-179	3	22	chemotherapy	chemotherapy	NOUN
clinmedi-179	3	23	(	(	PUNCT
clinmedi-179	3	24	nac	nac	PROPN
clinmedi-179	3	25	)	)	PUNCT
clinmedi-179	3	26	is	be	AUX
clinmedi-179	3	27	widely	widely	ADV
clinmedi-179	3	28	used	use	VERB
clinmedi-179	3	29	for	for	ADP
clinmedi-179	3	30	human	human	ADJ
clinmedi-179	3	31	epidermal	epidermal	ADJ
clinmedi-179	3	32	growth	growth	NOUN
clinmedi-179	3	33	factor	factor	NOUN
clinmedi-179	3	34	receptor	receptor	NOUN
clinmedi-179	3	35	2	2	NUM
clinmedi-179	3	36	-	-	PUNCT
clinmedi-179	3	37	positive	positive	ADJ
clinmedi-179	3	38	(	(	PUNCT
clinmedi-179	3	39	her2	her2	PROPN
clinmedi-179	3	40	+	+	NUM
clinmedi-179	3	41	)	)	PUNCT
clinmedi-179	3	42	breast	breast	NOUN
clinmedi-179	3	43	cancer	cancer	NOUN
clinmedi-179	3	44	.	.	PUNCT
clinmedi-179	4	1	the	the	DET
clinmedi-179	4	2	standard	standard	ADJ
clinmedi-179	4	3	nac	nac	PROPN
clinmedi-179	4	4	regimen	regimen	PROPN
clinmedi-179	4	5	for	for	ADP
clinmedi-179	4	6	her2	her2	PROPN
clinmedi-179	4	7	+	+	CCONJ
clinmedi-179	4	8	breast	breast	NOUN
clinmedi-179	4	9	cancer	cancer	NOUN
clinmedi-179	4	10	is	be	AUX
clinmedi-179	4	11	an	an	DET
clinmedi-179	4	12	anthracycline	anthracycline	NOUN
clinmedi-179	4	13	,	,	PUNCT
clinmedi-179	4	14	followed	follow	VERB
clinmedi-179	4	15	by	by	ADP
clinmedi-179	4	16	taxane	taxane	NOUN
clinmedi-179	4	17	in	in	ADP
clinmedi-179	4	18	combination	combination	NOUN
clinmedi-179	4	19	with	with	ADP
clinmedi-179	4	20	anti	anti	ADJ
clinmedi-179	4	21	-	-	ADJ
clinmedi-179	4	22	her2	her2	ADJ
clinmedi-179	4	23	drugs	drug	NOUN
clinmedi-179	4	24	.	.	PUNCT
clinmedi-179	5	1	however	however	ADV
clinmedi-179	5	2	,	,	PUNCT
clinmedi-179	5	3	the	the	DET
clinmedi-179	5	4	risk	risk	NOUN
clinmedi-179	5	5	of	of	ADP
clinmedi-179	5	6	toxicities	toxicity	NOUN
clinmedi-179	5	7	such	such	ADJ
clinmedi-179	5	8	as	as	ADP
clinmedi-179	5	9	cardiac	cardiac	ADJ
clinmedi-179	5	10	dysfunction	dysfunction	NOUN
clinmedi-179	5	11	and	and	CCONJ
clinmedi-179	5	12	peripheral	peripheral	ADJ
clinmedi-179	5	13	neuropathy	neuropathy	ADJ
clinmedi-179	5	14	occasionally	occasionally	ADV
clinmedi-179	5	15	requires	require	VERB
clinmedi-179	5	16	dose	dose	NOUN
clinmedi-179	5	17	reduction	reduction	NOUN
clinmedi-179	5	18	.	.	PUNCT
clinmedi-179	6	1	nanoparticle	nanoparticle	NOUN
clinmedi-179	6	2	albumin	albumin	NOUN
clinmedi-179	6	3	-	-	PUNCT
clinmedi-179	6	4	bound	bind	VERB
clinmedi-179	6	5	paclitaxel	paclitaxel	NOUN
clinmedi-179	6	6	(	(	PUNCT
clinmedi-179	6	7	nab	nab	NOUN
clinmedi-179	6	8	-	-	PUNCT
clinmedi-179	6	9	ptx	ptx	NOUN
clinmedi-179	6	10	)	)	PUNCT
clinmedi-179	6	11	is	be	AUX
clinmedi-179	6	12	a	a	DET
clinmedi-179	6	13	new	new	ADJ
clinmedi-179	6	14	taxane	taxane	NOUN
clinmedi-179	6	15	used	use	VERB
clinmedi-179	6	16	in	in	ADP
clinmedi-179	6	17	nac	nac	PROPN
clinmedi-179	6	18	.	.	PUNCT
clinmedi-179	7	1	the	the	DET
clinmedi-179	7	2	aim	aim	NOUN
clinmedi-179	7	3	of	of	ADP
clinmedi-179	7	4	this	this	DET
clinmedi-179	7	5	study	study	NOUN
clinmedi-179	7	6	was	be	AUX
clinmedi-179	7	7	to	to	PART
clinmedi-179	7	8	examine	examine	VERB
clinmedi-179	7	9	the	the	DET
clinmedi-179	7	10	effects	effect	NOUN
clinmedi-179	7	11	of	of	ADP
clinmedi-179	7	12	tri	tri	ADJ
clinmedi-179	7	13	-	-	ADJ
clinmedi-179	7	14	weekly	weekly	ADJ
clinmedi-179	7	15	low	low	ADV
clinmedi-179	7	16	-	-	PUNCT
clinmedi-179	7	17	dose	dose	NOUN
clinmedi-179	7	18	nab	nab	NOUN
clinmedi-179	7	19	-	-	PUNCT
clinmedi-179	7	20	ptx	ptx	NOUN
clinmedi-179	7	21	with	with	ADP
clinmedi-179	7	22	anti	anti	ADJ
clinmedi-179	7	23	-	-	ADJ
clinmedi-179	7	24	her2	her2	ADJ
clinmedi-179	7	25	drugs	drug	NOUN
clinmedi-179	7	26	followed	follow	VERB
clinmedi-179	7	27	by	by	ADP
clinmedi-179	7	28	fluorouracil	fluorouracil	NOUN
clinmedi-179	7	29	,	,	PUNCT
clinmedi-179	7	30	epirubicin	epirubicin	ADV
clinmedi-179	7	31	,	,	PUNCT
clinmedi-179	7	32	and	and	CCONJ
clinmedi-179	7	33	cyclophosphamide	cyclophosphamide	PROPN
clinmedi-179	7	34	(	(	PUNCT
clinmedi-179	7	35	fec	fec	PROPN
clinmedi-179	7	36	)	)	PUNCT
clinmedi-179	7	37	as	as	ADP
clinmedi-179	7	38	nac	nac	PROPN
clinmedi-179	7	39	in	in	ADP
clinmedi-179	7	40	patients	patient	NOUN
clinmedi-179	7	41	with	with	ADP
clinmedi-179	7	42	her2	her2	PROPN
clinmedi-179	7	43	+	+	CCONJ
clinmedi-179	7	44	breast	breast	NOUN
clinmedi-179	7	45	cancer	cancer	NOUN
clinmedi-179	7	46	.	.	PUNCT
clinmedi-179	8	1	methods	method	NOUN
clinmedi-179	8	2	:	:	PUNCT
clinmedi-179	8	3	patients	patient	NOUN
clinmedi-179	8	4	with	with	ADP
clinmedi-179	8	5	operable	operable	ADJ
clinmedi-179	8	6	primary	primary	ADJ
clinmedi-179	8	7	her2	her2	NOUN
clinmedi-179	8	8	+	+	CCONJ
clinmedi-179	8	9	breast	breast	NOUN
clinmedi-179	8	10	cancer	cancer	NOUN
clinmedi-179	8	11	in	in	ADP
clinmedi-179	8	12	clinical	clinical	ADJ
clinmedi-179	8	13	stages	stage	NOUN
clinmedi-179	8	14	i	i	PRON
clinmedi-179	8	15	–	–	PUNCT
clinmedi-179	8	16	iii	iii	NUM
clinmedi-179	8	17	were	be	AUX
clinmedi-179	8	18	enrolled	enrol	VERB
clinmedi-179	8	19	in	in	ADP
clinmedi-179	8	20	this	this	DET
clinmedi-179	8	21	study	study	NOUN
clinmedi-179	8	22	.	.	PUNCT
clinmedi-179	9	1	the	the	DET
clinmedi-179	9	2	nac	nac	PROPN
clinmedi-179	9	3	regimen	regimen	PROPN
clinmedi-179	9	4	included	include	VERB
clinmedi-179	9	5	four	four	NUM
clinmedi-179	9	6	courses	course	NOUN
clinmedi-179	9	7	of	of	ADP
clinmedi-179	9	8	nab	nab	NOUN
clinmedi-179	9	9	-	-	PUNCT
clinmedi-179	9	10	ptx	ptx	NOUN
clinmedi-179	9	11	(	(	PUNCT
clinmedi-179	9	12	220	220	NUM
clinmedi-179	9	13	mg	mg	NUM
clinmedi-179	9	14	/	/	SYM
clinmedi-179	9	15	m	m	VERB
clinmedi-179	9	16	2	2	NUM
clinmedi-179	9	17	)	)	PUNCT
clinmedi-179	9	18	concurrently	concurrently	ADV
clinmedi-179	9	19	with	with	ADP
clinmedi-179	9	20	trastuzumab	trastuzumab	NOUN
clinmedi-179	9	21	(	(	PUNCT
clinmedi-179	9	22	6	6	NUM
clinmedi-179	9	23	mg	mg	NUM
clinmedi-179	9	24	/	/	SYM
clinmedi-179	9	25	kg	kg	NOUN
clinmedi-179	9	26	)	)	PUNCT
clinmedi-179	9	27	tri	tri	ADJ
clinmedi-179	9	28	-	-	ADJ
clinmedi-179	9	29	weekly	weekly	ADJ
clinmedi-179	9	30	,	,	PUNCT
clinmedi-179	9	31	followed	follow	VERB
clinmedi-179	9	32	by	by	ADP
clinmedi-179	9	33	four	four	NUM
clinmedi-179	9	34	courses	course	NOUN
clinmedi-179	9	35	of	of	ADP
clinmedi-179	9	36	fec75	fec75	PROPN
clinmedi-179	9	37	(	(	PUNCT
clinmedi-179	9	38	5	5	NUM
clinmedi-179	9	39	-	-	PUNCT
clinmedi-179	9	40	fluorouracil	fluorouracil	NOUN
clinmedi-179	9	41	:	:	PUNCT
clinmedi-179	9	42	500	500	NUM
clinmedi-179	9	43	mg	mg	NUM
clinmedi-179	9	44	/	/	SYM
clinmedi-179	9	45	m	m	PROPN
clinmedi-179	9	46	2	2	NUM
clinmedi-179	9	47	,	,	PUNCT
clinmedi-179	9	48	epirubicin	epirubicin	PRON
clinmedi-179	9	49	:	:	PUNCT
clinmedi-179	9	50	75	75	NUM
clinmedi-179	9	51	mg	mg	NUM
clinmedi-179	9	52	/	/	SYM
clinmedi-179	9	53	m	m	PROPN
clinmedi-179	9	54	2	2	NUM
clinmedi-179	9	55	,	,	PUNCT
clinmedi-179	9	56	and	and	CCONJ
clinmedi-179	9	57	cyclophosphamide	cyclophosphamide	NOUN
clinmedi-179	9	58	:	:	PUNCT
clinmedi-179	9	59	500	500	NUM
clinmedi-179	9	60	mg	mg	NUM
clinmedi-179	9	61	/	/	SYM
clinmedi-179	9	62	m	m	PROPN
clinmedi-179	9	63	2	2	NUM
clinmedi-179	9	64	)	)	PUNCT
clinmedi-179	9	65	.	.	PUNCT
clinmedi-179	10	1	pathological	pathological	ADJ
clinmedi-179	10	2	responses	response	NOUN
clinmedi-179	10	3	,	,	PUNCT
clinmedi-179	10	4	adverse	adverse	ADJ
clinmedi-179	10	5	events	event	NOUN
clinmedi-179	10	6	,	,	PUNCT
clinmedi-179	10	7	and	and	CCONJ
clinmedi-179	10	8	follow	follow	VERB
clinmedi-179	10	9	-	-	PUNCT
clinmedi-179	10	10	up	up	ADP
clinmedi-179	10	11	data	datum	NOUN
clinmedi-179	10	12	at	at	ADP
clinmedi-179	10	13	36	36	NUM
clinmedi-179	10	14	months	month	NOUN
clinmedi-179	10	15	were	be	AUX
clinmedi-179	10	16	evaluated	evaluate	VERB
clinmedi-179	10	17	.	.	PUNCT
clinmedi-179	11	1	results	result	NOUN
clinmedi-179	11	2	:	:	PUNCT
clinmedi-179	11	3	among	among	ADP
clinmedi-179	11	4	the	the	DET
clinmedi-179	11	5	20	20	NUM
clinmedi-179	11	6	patients	patient	NOUN
clinmedi-179	11	7	enrolled	enrol	VERB
clinmedi-179	11	8	,	,	PUNCT
clinmedi-179	11	9	15	15	NUM
clinmedi-179	11	10	completed	complete	VERB
clinmedi-179	11	11	the	the	DET
clinmedi-179	11	12	treatment	treatment	NOUN
clinmedi-179	11	13	protocol	protocol	NOUN
clinmedi-179	11	14	.	.	PUNCT
clinmedi-179	12	1	the	the	DET
clinmedi-179	12	2	pathological	pathological	ADJ
clinmedi-179	12	3	complete	complete	ADJ
clinmedi-179	12	4	response	response	NOUN
clinmedi-179	12	5	(	(	PUNCT
clinmedi-179	12	6	pcr	pcr	ADJ
clinmedi-179	12	7	)	)	PUNCT
clinmedi-179	12	8	rates	rate	NOUN
clinmedi-179	12	9	were	be	AUX
clinmedi-179	12	10	60.0	60.0	NUM
clinmedi-179	12	11	%	%	NOUN
clinmedi-179	12	12	overall	overall	ADJ
clinmedi-179	12	13	and	and	CCONJ
clinmedi-179	12	14	85.7	85.7	NUM
clinmedi-179	12	15	%	%	NOUN
clinmedi-179	12	16	in	in	ADP
clinmedi-179	12	17	hormone	hormone	NOUN
clinmedi-179	12	18	receptor	receptor	NOUN
clinmedi-179	12	19	-	-	PUNCT
clinmedi-179	12	20	negative	negative	NOUN
clinmedi-179	12	21	/	/	SYM
clinmedi-179	12	22	her2	her2	PROPN
clinmedi-179	12	23	+	+	CCONJ
clinmedi-179	12	24	patients	patient	NOUN
clinmedi-179	12	25	.	.	PUNCT
clinmedi-179	13	1	at	at	ADP
clinmedi-179	13	2	36	36	NUM
clinmedi-179	13	3	months	month	NOUN
clinmedi-179	13	4	,	,	PUNCT
clinmedi-179	13	5	one	one	NUM
clinmedi-179	13	6	secondary	secondary	ADJ
clinmedi-179	13	7	malignancy	malignancy	NOUN
clinmedi-179	13	8	was	be	AUX
clinmedi-179	13	9	observed	observe	VERB
clinmedi-179	13	10	.	.	PUNCT
clinmedi-179	14	1	the	the	DET
clinmedi-179	14	2	most	most	ADV
clinmedi-179	14	3	frequent	frequent	ADJ
clinmedi-179	14	4	adverse	adverse	ADJ
clinmedi-179	14	5	event	event	NOUN
clinmedi-179	14	6	was	be	AUX
clinmedi-179	14	7	peripheral	peripheral	ADJ
clinmedi-179	14	8	sensory	sensory	ADJ
clinmedi-179	14	9	neuropathy	neuropathy	ADJ
clinmedi-179	14	10	(	(	PUNCT
clinmedi-179	14	11	25/42	25/42	NUM
clinmedi-179	14	12	,	,	PUNCT
clinmedi-179	14	13	59.5	59.5	NUM
clinmedi-179	14	14	%	%	NOUN
clinmedi-179	14	15	)	)	PUNCT
clinmedi-179	14	16	,	,	PUNCT
clinmedi-179	14	17	which	which	PRON
clinmedi-179	14	18	persisted	persist	VERB
clinmedi-179	14	19	in	in	ADP
clinmedi-179	14	20	four	four	NUM
clinmedi-179	14	21	(	(	PUNCT
clinmedi-179	14	22	16	16	NUM
clinmedi-179	14	23	%	%	NOUN
clinmedi-179	14	24	)	)	PUNCT
clinmedi-179	14	25	patients	patient	NOUN
clinmedi-179	14	26	at	at	ADP
clinmedi-179	14	27	36	36	NUM
clinmedi-179	14	28	-	-	PUNCT
clinmedi-179	14	29	month	month	NOUN
clinmedi-179	14	30	follow	follow	NOUN
clinmedi-179	14	31	-	-	PUNCT
clinmedi-179	14	32	up	up	NOUN
clinmedi-179	14	33	.	.	PUNCT
clinmedi-179	15	1	conclusions	conclusion	NOUN
clinmedi-179	15	2	:	:	PUNCT
clinmedi-179	15	3	nac	nac	PROPN
clinmedi-179	15	4	with	with	ADP
clinmedi-179	15	5	low	low	ADJ
clinmedi-179	15	6	-	-	PUNCT
clinmedi-179	15	7	dose	dose	NOUN
clinmedi-179	15	8	tri	tri	ADJ
clinmedi-179	15	9	-	-	ADJ
clinmedi-179	15	10	weekly	weekly	ADJ
clinmedi-179	15	11	nab	nab	NOUN
clinmedi-179	15	12	-	-	PUNCT
clinmedi-179	15	13	ptx	ptx	NOUN
clinmedi-179	15	14	followed	follow	VERB
clinmedi-179	15	15	by	by	ADP
clinmedi-179	15	16	fec	fec	PROPN
clinmedi-179	15	17	demonstrated	demonstrate	VERB
clinmedi-179	15	18	favorable	favorable	ADJ
clinmedi-179	15	19	pcr	pcr	ADJ
clinmedi-179	15	20	and	and	CCONJ
clinmedi-179	15	21	disease	disease	NOUN
clinmedi-179	15	22	-	-	PUNCT
clinmedi-179	15	23	free	free	ADJ
clinmedi-179	15	24	survival	survival	NOUN
clinmedi-179	15	25	.	.	PUNCT
clinmedi-179	16	1	peripheral	peripheral	ADJ
clinmedi-179	16	2	sensory	sensory	ADJ
clinmedi-179	16	3	neuropathy	neuropathy	ADJ
clinmedi-179	16	4	remains	remain	VERB
clinmedi-179	16	5	a	a	DET
clinmedi-179	16	6	concerning	concern	VERB
clinmedi-179	16	7	long	long	ADJ
clinmedi-179	16	8	-	-	PUNCT
clinmedi-179	16	9	term	term	NOUN
clinmedi-179	16	10	adverse	adverse	ADJ
clinmedi-179	16	11	effect	effect	NOUN
clinmedi-179	16	12	in	in	ADP
clinmedi-179	16	13	some	some	DET
clinmedi-179	16	14	patients	patient	NOUN
clinmedi-179	16	15	,	,	PUNCT
clinmedi-179	16	16	even	even	ADV
clinmedi-179	16	17	after	after	ADP
clinmedi-179	16	18	reducing	reduce	VERB
clinmedi-179	16	19	the	the	DET
clinmedi-179	16	20	nab	nab	ADJ
clinmedi-179	16	21	-	-	PUNCT
clinmedi-179	16	22	ptx	ptx	NOUN
clinmedi-179	16	23	dosage	dosage	NOUN
clinmedi-179	16	24	.	.	PUNCT
clinmedi-179	17	1	keywords	keyword	NOUN
clinmedi-179	17	2	:	:	PUNCT
clinmedi-179	17	3	albumin	albumin	ADJ
clinmedi-179	17	4	-	-	PUNCT
clinmedi-179	17	5	bound	bind	VERB
clinmedi-179	17	6	paclitaxel	paclitaxel	NOUN
clinmedi-179	17	7	,	,	PUNCT
clinmedi-179	17	8	human	human	ADJ
clinmedi-179	17	9	epidermal	epidermal	ADJ
clinmedi-179	17	10	growth	growth	NOUN
clinmedi-179	17	11	factor	factor	NOUN
clinmedi-179	17	12	receptor	receptor	NOUN
clinmedi-179	17	13	2	2	NUM
clinmedi-179	17	14	,	,	PUNCT
clinmedi-179	17	15	neoadjuvant	neoadjuvant	ADJ
clinmedi-179	17	16	chemotherapy	chemotherapy	NOUN
clinmedi-179	17	17	,	,	PUNCT
clinmedi-179	17	18	breast	breast	NOUN
clinmedi-179	17	19	cancer	cancer	NOUN
clinmedi-179	17	20	,	,	PUNCT
clinmedi-179	17	21	peripheral	peripheral	ADJ
clinmedi-179	17	22	neuropathy	neuropathy	ADJ
clinmedi-179	17	23	copyright	copyright	NOUN
clinmedi-179	17	24	:	:	PUNCT
clinmedi-179	17	25	©	©	PROPN
clinmedi-179	17	26	2021	2021	NUM
clinmedi-179	17	27	the	the	DET
clinmedi-179	17	28	authors	author	NOUN
clinmedi-179	17	29	.	.	PUNCT
clinmedi-179	18	1	published	publish	VERB
clinmedi-179	18	2	by	by	ADP
clinmedi-179	18	3	medical	medical	ADJ
clinmedi-179	18	4	editor	editor	NOUN
clinmedi-179	18	5	and	and	CCONJ
clinmedi-179	18	6	educational	educational	ADJ
clinmedi-179	18	7	research	research	NOUN
clinmedi-179	18	8	publishers	publishers	PROPN
clinmedi-179	18	9	ltd	ltd	PROPN
clinmedi-179	18	10	.	.	PUNCT
clinmedi-179	19	1	this	this	PRON
clinmedi-179	19	2	is	be	AUX
clinmedi-179	19	3	an	an	DET
clinmedi-179	19	4	open	open	ADJ
clinmedi-179	19	5	access	access	NOUN
clinmedi-179	19	6	article	article	NOUN
clinmedi-179	19	7	under	under	ADP
clinmedi-179	19	8	the	the	DET
clinmedi-179	19	9	cc	cc	PROPN
clinmedi-179	19	10	by	by	ADP
clinmedi-179	19	11	-	-	PUNCT
clinmedi-179	19	12	nc	nc	VERB
clinmedi-179	19	13	-	-	PUNCT
clinmedi-179	19	14	nd	nd	NOUN
clinmedi-179	19	15	license	license	NOUN
clinmedi-179	19	16	(	(	PUNCT
clinmedi-179	19	17	https://creativecommons.org/lic	https://creativecommons.org/lic	PROPN
clinmedi-179	19	18	enses	ense	NOUN
clinmedi-179	19	19	/	/	SYM
clinmedi-179	19	20	bync	bync	NOUN
clinmedi-179	19	21	-	-	PUNCT
clinmedi-179	19	22	nd/4.0/	nd/4.0/	NOUN
clinmedi-179	19	23	)	)	PUNCT
clinmedi-179	19	24	.	.	PUNCT
clinmedi-179	20	1	https://doi.org/10.52845/cmi/2023-4-2-1	https://doi.org/10.52845/cmi/2023-4-2-1	PROPN
clinmedi-179	20	2	https://creativecommons.org/lic%20enses/by-nc-nd/4.0/	https://creativecommons.org/lic%20enses/by-nc-nd/4.0/	NOUN
clinmedi-179	20	3	https://creativecommons.org/lic%20enses/by-nc-nd/4.0/	https://creativecommons.org/lic%20enses/by-nc-nd/4.0/	NOUN
clinmedi-179	20	4	cmi	cmi	PROPN
clinmedi-179	20	5	04	04	PROPN
clinmedi-179	20	6	(	(	PUNCT
clinmedi-179	20	7	02	02	NUM
clinmedi-179	20	8	)	)	PUNCT
clinmedi-179	20	9	,	,	PUNCT
clinmedi-179	20	10	378−386	378−386	NUM
clinmedi-179	20	11	cmi	cmi	PROPN
clinmedi-179	20	12	journal	journal	PROPN
clinmedi-179	20	13	379	379	NUM
clinmedi-179	20	14	cmi	cmi	PROPN
clinmedi-179	20	15	journal	journal	PROPN
clinmedi-179	20	16	kazumi	kazumi	PROPN
clinmedi-179	20	17	kawase	kawase	PROPN
clinmedi-179	20	18	et	et	PROPN
clinmedi-179	20	19	al	al	PROPN
clinmedi-179	20	20	.	.	PROPN
clinmedi-179	20	21	docetaxel	docetaxel	PROPN
clinmedi-179	20	22	1	1	NUM
clinmedi-179	20	23	;	;	PUNCT
clinmedi-179	20	24	however	however	ADV
clinmedi-179	20	25	,	,	PUNCT
clinmedi-179	20	26	their	their	PRON
clinmedi-179	20	27	adverse	adverse	ADJ
clinmedi-179	20	28	effects	effect	NOUN
clinmedi-179	20	29	(	(	PUNCT
clinmedi-179	20	30	e.g.	e.g.	ADV
clinmedi-179	20	31	,	,	PUNCT
clinmedi-179	20	32	peripheral	peripheral	ADJ
clinmedi-179	20	33	neuropathy	neuropathy	ADJ
clinmedi-179	20	34	and	and	CCONJ
clinmedi-179	20	35	allergic	allergic	ADJ
clinmedi-179	20	36	reactions	reaction	NOUN
clinmedi-179	20	37	)	)	PUNCT
clinmedi-179	20	38	are	be	AUX
clinmedi-179	20	39	associated	associate	VERB
clinmedi-179	20	40	with	with	ADP
clinmedi-179	20	41	the	the	DET
clinmedi-179	20	42	vehicles	vehicle	NOUN
clinmedi-179	20	43	such	such	ADJ
clinmedi-179	20	44	as	as	ADP
clinmedi-179	20	45	polyethylated	polyethylate	VERB
clinmedi-179	20	46	castor	castor	NOUN
clinmedi-179	20	47	oil	oil	NOUN
clinmedi-179	20	48	and	and	CCONJ
clinmedi-179	20	49	ethanol	ethanol	NOUN
clinmedi-179	20	50	which	which	PRON
clinmedi-179	20	51	are	be	AUX
clinmedi-179	20	52	used	use	VERB
clinmedi-179	20	53	in	in	ADP
clinmedi-179	20	54	the	the	DET
clinmedi-179	20	55	formulation	formulation	NOUN
clinmedi-179	20	56	of	of	ADP
clinmedi-179	20	57	these	these	DET
clinmedi-179	20	58	drugs	drug	NOUN
clinmedi-179	20	59	that	that	PRON
clinmedi-179	20	60	limits	limit	VERB
clinmedi-179	20	61	their	their	PRON
clinmedi-179	20	62	longterm	longterm	ADJ
clinmedi-179	20	63	efficacy	efficacy	NOUN
clinmedi-179	20	64	.	.	PUNCT
clinmedi-179	21	1	nanoparticle	nanoparticle	NOUN
clinmedi-179	21	2	albumin	albumin	NOUN
clinmedi-179	21	3	-	-	PUNCT
clinmedi-179	21	4	bound	bind	VERB
clinmedi-179	21	5	ptx	ptx	NOUN
clinmedi-179	21	6	(	(	PUNCT
clinmedi-179	21	7	nab	nab	NOUN
clinmedi-179	21	8	-	-	PUNCT
clinmedi-179	21	9	ptx	ptx	NOUN
clinmedi-179	21	10	)	)	PUNCT
clinmedi-179	21	11	is	be	AUX
clinmedi-179	21	12	a	a	DET
clinmedi-179	21	13	solvent	solvent	NOUN
clinmedi-179	21	14	-	-	PUNCT
clinmedi-179	21	15	free	free	ADJ
clinmedi-179	21	16	,	,	PUNCT
clinmedi-179	21	17	130	130	NUM
clinmedi-179	21	18	nm	nm	ADJ
clinmedi-179	21	19	particle	particle	NOUN
clinmedi-179	21	20	form	form	NOUN
clinmedi-179	21	21	of	of	ADP
clinmedi-179	21	22	ptx	ptx	NOUN
clinmedi-179	21	23	bound	bind	VERB
clinmedi-179	21	24	to	to	ADP
clinmedi-179	21	25	albumin	albumin	NOUN
clinmedi-179	21	26	,	,	PUNCT
clinmedi-179	21	27	which	which	PRON
clinmedi-179	21	28	was	be	AUX
clinmedi-179	21	29	developed	develop	VERB
clinmedi-179	21	30	to	to	PART
clinmedi-179	21	31	avoid	avoid	VERB
clinmedi-179	21	32	such	such	ADJ
clinmedi-179	21	33	adverse	adverse	ADJ
clinmedi-179	21	34	effects	effect	NOUN
clinmedi-179	21	35	.	.	PUNCT
clinmedi-179	22	1	although	although	SCONJ
clinmedi-179	22	2	nab	nab	NOUN
clinmedi-179	22	3	-	-	PUNCT
clinmedi-179	22	4	ptx	ptx	NOUN
clinmedi-179	22	5	has	have	AUX
clinmedi-179	22	6	been	be	AUX
clinmedi-179	22	7	utilized	utilize	VERB
clinmedi-179	22	8	as	as	ADP
clinmedi-179	22	9	a	a	DET
clinmedi-179	22	10	nac	nac	NOUN
clinmedi-179	22	11	in	in	ADP
clinmedi-179	22	12	breast	breast	NOUN
clinmedi-179	22	13	cancer	cancer	NOUN
clinmedi-179	22	14	,	,	PUNCT
clinmedi-179	22	15	toxicities	toxicity	NOUN
clinmedi-179	22	16	such	such	ADJ
clinmedi-179	22	17	as	as	ADP
clinmedi-179	22	18	peripheral	peripheral	ADJ
clinmedi-179	22	19	neuropathy	neuropathy	ADJ
clinmedi-179	22	20	are	be	AUX
clinmedi-179	22	21	still	still	ADV
clinmedi-179	22	22	observed	observe	VERB
clinmedi-179	22	23	,	,	PUNCT
clinmedi-179	22	24	necessitating	necessitate	VERB
clinmedi-179	22	25	dose	dose	NOUN
clinmedi-179	22	26	reduction	reduction	NOUN
clinmedi-179	22	27	to	to	PART
clinmedi-179	22	28	complete	complete	VERB
clinmedi-179	22	29	the	the	DET
clinmedi-179	22	30	treatment	treatment	NOUN
clinmedi-179	22	31	.	.	PUNCT
clinmedi-179	23	1	2	2	NUM
clinmedi-179	23	2	in	in	ADP
clinmedi-179	23	3	addition	addition	NOUN
clinmedi-179	23	4	,	,	PUNCT
clinmedi-179	23	5	the	the	DET
clinmedi-179	23	6	long	long	ADJ
clinmedi-179	23	7	-	-	PUNCT
clinmedi-179	23	8	term	term	NOUN
clinmedi-179	23	9	adverse	adverse	ADJ
clinmedi-179	23	10	events	event	NOUN
clinmedi-179	23	11	of	of	ADP
clinmedi-179	23	12	nab	nab	NOUN
clinmedi-179	23	13	-	-	PUNCT
clinmedi-179	23	14	ptx	ptx	NOUN
clinmedi-179	23	15	have	have	AUX
clinmedi-179	23	16	not	not	PART
clinmedi-179	23	17	been	be	AUX
clinmedi-179	23	18	widely	widely	ADV
clinmedi-179	23	19	examined	examine	VERB
clinmedi-179	23	20	,	,	PUNCT
clinmedi-179	23	21	and	and	CCONJ
clinmedi-179	23	22	thus	thus	ADV
clinmedi-179	23	23	further	further	ADJ
clinmedi-179	23	24	research	research	NOUN
clinmedi-179	23	25	is	be	AUX
clinmedi-179	23	26	required	require	VERB
clinmedi-179	23	27	.	.	PUNCT
clinmedi-179	24	1	in	in	ADP
clinmedi-179	24	2	2014	2014	NUM
clinmedi-179	24	3	,	,	PUNCT
clinmedi-179	24	4	we	we	PRON
clinmedi-179	24	5	conducted	conduct	VERB
clinmedi-179	24	6	a	a	DET
clinmedi-179	24	7	single	single	ADJ
clinmedi-179	24	8	-	-	PUNCT
clinmedi-179	24	9	institution	institution	NOUN
clinmedi-179	24	10	phase	phase	NOUN
clinmedi-179	24	11	ii	ii	NOUN
clinmedi-179	24	12	clinical	clinical	ADJ
clinmedi-179	24	13	study	study	NOUN
clinmedi-179	24	14	(	(	PUNCT
clinmedi-179	24	15	nab	nab	NOUN
clinmedi-179	24	16	-	-	PUNCT
clinmedi-179	24	17	ptx220	ptx220	NOUN
clinmedi-179	24	18	study	study	NOUN
clinmedi-179	24	19	)	)	PUNCT
clinmedi-179	24	20	with	with	ADP
clinmedi-179	24	21	reduced	reduce	VERB
clinmedi-179	24	22	doses	dose	NOUN
clinmedi-179	24	23	of	of	ADP
clinmedi-179	24	24	tri	tri	ADJ
clinmedi-179	24	25	-	-	ADJ
clinmedi-179	24	26	weekly	weekly	ADJ
clinmedi-179	24	27	q3w	q3w	NOUN
clinmedi-179	24	28	nab	nab	NOUN
clinmedi-179	24	29	-	-	PUNCT
clinmedi-179	24	30	ptx	ptx	NOUN
clinmedi-179	24	31	and	and	CCONJ
clinmedi-179	24	32	fec	fec	PROPN
clinmedi-179	24	33	(	(	PUNCT
clinmedi-179	24	34	5fluorouracil	5fluorouracil	NUM
clinmedi-179	24	35	:	:	SYM
clinmedi-179	24	36	500	500	NUM
clinmedi-179	24	37	mg	mg	NUM
clinmedi-179	24	38	/	/	SYM
clinmedi-179	24	39	m	m	PROPN
clinmedi-179	24	40	2	2	NUM
clinmedi-179	24	41	,	,	PUNCT
clinmedi-179	24	42	epirubicin	epirubicin	PRON
clinmedi-179	24	43	:	:	PUNCT
clinmedi-179	24	44	75	75	NUM
clinmedi-179	24	45	mg	mg	NUM
clinmedi-179	24	46	/	/	SYM
clinmedi-179	24	47	m	m	PROPN
clinmedi-179	24	48	2	2	NUM
clinmedi-179	24	49	,	,	PUNCT
clinmedi-179	24	50	and	and	CCONJ
clinmedi-179	24	51	cyclophosphamide	cyclophosphamide	NOUN
clinmedi-179	24	52	:	:	PUNCT
clinmedi-179	24	53	500	500	NUM
clinmedi-179	24	54	mg	mg	NUM
clinmedi-179	24	55	/	/	SYM
clinmedi-179	24	56	m	m	PROPN
clinmedi-179	24	57	2	2	NUM
clinmedi-179	24	58	)	)	PUNCT
clinmedi-179	24	59	to	to	PART
clinmedi-179	24	60	assess	assess	VERB
clinmedi-179	24	61	the	the	DET
clinmedi-179	24	62	efficacy	efficacy	NOUN
clinmedi-179	24	63	and	and	CCONJ
clinmedi-179	24	64	safety	safety	NOUN
clinmedi-179	24	65	of	of	ADP
clinmedi-179	24	66	dose	dose	NOUN
clinmedi-179	24	67	-	-	PUNCT
clinmedi-179	24	68	reduced	reduce	VERB
clinmedi-179	24	69	nab	nab	NOUN
clinmedi-179	24	70	-	-	PUNCT
clinmedi-179	24	71	ptx	ptx	NOUN
clinmedi-179	24	72	as	as	ADP
clinmedi-179	24	73	an	an	DET
clinmedi-179	24	74	nac	nac	PROPN
clinmedi-179	24	75	.	.	PROPN
clinmedi-179	24	76	herein	herein	PROPN
clinmedi-179	24	77	,	,	PUNCT
clinmedi-179	24	78	we	we	PRON
clinmedi-179	24	79	report	report	VERB
clinmedi-179	24	80	these	these	DET
clinmedi-179	24	81	results	result	NOUN
clinmedi-179	24	82	,	,	PUNCT
clinmedi-179	24	83	along	along	ADP
clinmedi-179	24	84	with	with	ADP
clinmedi-179	24	85	the	the	DET
clinmedi-179	24	86	long	long	ADJ
clinmedi-179	24	87	-	-	PUNCT
clinmedi-179	24	88	term	term	NOUN
clinmedi-179	24	89	outcomes	outcome	NOUN
clinmedi-179	24	90	,	,	PUNCT
clinmedi-179	24	91	including	include	VERB
clinmedi-179	24	92	the	the	DET
clinmedi-179	24	93	adverse	adverse	ADJ
clinmedi-179	24	94	effects	effect	NOUN
clinmedi-179	24	95	.	.	PUNCT
clinmedi-179	25	1	material	material	NOUN
clinmedi-179	25	2	and	and	CCONJ
clinmedi-179	25	3	methods	method	NOUN
clinmedi-179	25	4	nab	nab	ADJ
clinmedi-179	25	5	-	-	PUNCT
clinmedi-179	25	6	ptx220	ptx220	NOUN
clinmedi-179	25	7	study	study	NOUN
clinmedi-179	25	8	design	design	NOUN
clinmedi-179	25	9	women	woman	NOUN
clinmedi-179	25	10	aged	age	VERB
clinmedi-179	25	11	≥20	≥20	VERB
clinmedi-179	25	12	years	year	NOUN
clinmedi-179	25	13	with	with	ADP
clinmedi-179	25	14	histologically	histologically	NOUN
clinmedi-179	25	15	confirmed	confirm	VERB
clinmedi-179	25	16	breast	breast	NOUN
clinmedi-179	25	17	cancer	cancer	NOUN
clinmedi-179	25	18	were	be	AUX
clinmedi-179	25	19	included	include	VERB
clinmedi-179	25	20	in	in	ADP
clinmedi-179	25	21	this	this	DET
clinmedi-179	25	22	study	study	NOUN
clinmedi-179	25	23	.	.	PUNCT
clinmedi-179	26	1	the	the	DET
clinmedi-179	26	2	inclusion	inclusion	NOUN
clinmedi-179	26	3	criteria	criterion	NOUN
clinmedi-179	26	4	were	be	AUX
clinmedi-179	26	5	as	as	SCONJ
clinmedi-179	26	6	follows	follow	VERB
clinmedi-179	26	7	:	:	PUNCT
clinmedi-179	26	8	eastern	eastern	ADJ
clinmedi-179	26	9	cooperative	cooperative	ADJ
clinmedi-179	26	10	oncology	oncology	NOUN
clinmedi-179	26	11	group	group	NOUN
clinmedi-179	26	12	performance	performance	NOUN
clinmedi-179	26	13	status	status	NOUN
clinmedi-179	26	14	of	of	ADP
clinmedi-179	26	15	0–1	0–1	NOUN
clinmedi-179	26	16	;	;	PUNCT
clinmedi-179	26	17	clinical	clinical	ADJ
clinmedi-179	26	18	stage	stage	NOUN
clinmedi-179	26	19	t1c-3	t1c-3	PROPN
clinmedi-179	26	20	,	,	PUNCT
clinmedi-179	26	21	n0	n0	PROPN
clinmedi-179	26	22	/	/	SYM
clinmedi-179	26	23	m0	m0	PROPN
clinmedi-179	26	24	or	or	CCONJ
clinmedi-179	26	25	t1	t1	PROPN
clinmedi-179	26	26	-	-	PUNCT
clinmedi-179	26	27	3	3	NUM
clinmedi-179	26	28	,	,	PUNCT
clinmedi-179	26	29	n1	n1	NOUN
clinmedi-179	26	30	/	/	SYM
clinmedi-179	26	31	m0	m0	NOUN
clinmedi-179	26	32	;	;	PUNCT
clinmedi-179	26	33	adequate	adequate	ADJ
clinmedi-179	26	34	bone	bone	NOUN
clinmedi-179	26	35	marrow	marrow	NOUN
clinmedi-179	26	36	,	,	PUNCT
clinmedi-179	26	37	liver	liver	NOUN
clinmedi-179	26	38	,	,	PUNCT
clinmedi-179	26	39	and	and	CCONJ
clinmedi-179	26	40	kidney	kidney	NOUN
clinmedi-179	26	41	function	function	NOUN
clinmedi-179	26	42	;	;	PUNCT
clinmedi-179	26	43	estrogen	estrogen	NOUN
clinmedi-179	26	44	receptor	receptor	NOUN
clinmedi-179	26	45	(	(	PUNCT
clinmedi-179	26	46	er	er	INTJ
clinmedi-179	26	47	)	)	PUNCT
clinmedi-179	26	48	,	,	PUNCT
clinmedi-179	26	49	progesterone	progesterone	NOUN
clinmedi-179	26	50	receptor	receptor	NOUN
clinmedi-179	26	51	(	(	PUNCT
clinmedi-179	26	52	pgr	pgr	PROPN
clinmedi-179	26	53	)	)	PUNCT
clinmedi-179	26	54	and	and	CCONJ
clinmedi-179	26	55	human	human	ADJ
clinmedi-179	26	56	epidermal	epidermal	ADJ
clinmedi-179	26	57	growth	growth	NOUN
clinmedi-179	26	58	factor	factor	NOUN
clinmedi-179	26	59	receptor-2	receptor-2	NUM
clinmedi-179	26	60	(	(	PUNCT
clinmedi-179	26	61	her2	her2	PROPN
clinmedi-179	26	62	)	)	PUNCT
clinmedi-179	26	63	expression	expression	NOUN
clinmedi-179	26	64	status	status	NOUN
clinmedi-179	26	65	confirmed	confirm	VERB
clinmedi-179	26	66	using	use	VERB
clinmedi-179	26	67	core	core	NOUN
clinmedi-179	26	68	needle	needle	NOUN
clinmedi-179	26	69	biopsy	biopsy	NOUN
clinmedi-179	26	70	specimens	specimen	NOUN
clinmedi-179	26	71	;	;	PUNCT
clinmedi-179	26	72	curative	curative	ADJ
clinmedi-179	26	73	surgery	surgery	NOUN
clinmedi-179	26	74	were	be	AUX
clinmedi-179	26	75	performed	perform	VERB
clinmedi-179	26	76	following	follow	VERB
clinmedi-179	26	77	neoadjuvant	neoadjuvant	ADJ
clinmedi-179	26	78	treatment	treatment	NOUN
clinmedi-179	26	79	.	.	PUNCT
clinmedi-179	27	1	primary	primary	ADJ
clinmedi-179	27	2	lesion	lesion	NOUN
clinmedi-179	27	3	and	and	CCONJ
clinmedi-179	27	4	lymph	lymph	NOUN
clinmedi-179	27	5	nodes	node	NOUN
clinmedi-179	27	6	were	be	AUX
clinmedi-179	27	7	detected	detect	VERB
clinmedi-179	27	8	using	use	VERB
clinmedi-179	27	9	ultrasonography	ultrasonography	NOUN
clinmedi-179	27	10	,	,	PUNCT
clinmedi-179	27	11	computed	compute	VERB
clinmedi-179	27	12	tomography	tomography	NOUN
clinmedi-179	27	13	,	,	PUNCT
clinmedi-179	27	14	or	or	CCONJ
clinmedi-179	27	15	magnetic	magnetic	ADJ
clinmedi-179	27	16	resonance	resonance	NOUN
clinmedi-179	27	17	imaging	imaging	NOUN
clinmedi-179	27	18	.	.	PUNCT
clinmedi-179	28	1	no	no	DET
clinmedi-179	28	2	history	history	NOUN
clinmedi-179	28	3	of	of	ADP
clinmedi-179	28	4	therapy	therapy	NOUN
clinmedi-179	28	5	,	,	PUNCT
clinmedi-179	28	6	including	include	VERB
clinmedi-179	28	7	chemotherapy	chemotherapy	NOUN
clinmedi-179	28	8	,	,	PUNCT
clinmedi-179	28	9	radiotherapy	radiotherapy	NOUN
clinmedi-179	28	10	,	,	PUNCT
clinmedi-179	28	11	hormonal	hormonal	ADJ
clinmedi-179	28	12	therapy	therapy	NOUN
clinmedi-179	28	13	,	,	PUNCT
clinmedi-179	28	14	and	and	CCONJ
clinmedi-179	28	15	immunotherapy	immunotherapy	NOUN
clinmedi-179	28	16	and	and	CCONJ
clinmedi-179	28	17	malignancy	malignancy	NOUN
clinmedi-179	28	18	.	.	PUNCT
clinmedi-179	29	1	the	the	DET
clinmedi-179	29	2	written	write	VERB
clinmedi-179	29	3	informed	inform	VERB
clinmedi-179	29	4	consent	consent	NOUN
clinmedi-179	29	5	were	be	AUX
clinmedi-179	29	6	obtained	obtain	VERB
clinmedi-179	29	7	from	from	ADP
clinmedi-179	29	8	all	all	DET
clinmedi-179	29	9	the	the	DET
clinmedi-179	29	10	participants	participant	NOUN
clinmedi-179	29	11	.	.	PUNCT
clinmedi-179	30	1	the	the	DET
clinmedi-179	30	2	her2	her2	PROPN
clinmedi-179	30	3	was	be	AUX
clinmedi-179	30	4	defined	define	VERB
clinmedi-179	30	5	as	as	ADP
clinmedi-179	30	6	positive	positive	ADJ
clinmedi-179	30	7	according	accord	VERB
clinmedi-179	30	8	to	to	ADP
clinmedi-179	30	9	an	an	DET
clinmedi-179	30	10	immunohistochemical	immunohistochemical	ADJ
clinmedi-179	30	11	her2	her2	NOUN
clinmedi-179	30	12	protein	protein	NOUN
clinmedi-179	30	13	staining	stain	VERB
clinmedi-179	30	14	score	score	NOUN
clinmedi-179	30	15	of	of	ADP
clinmedi-179	30	16	3	3	NUM
clinmedi-179	30	17	+	+	NOUN
clinmedi-179	30	18	in	in	ADP
clinmedi-179	30	19	>	>	NUM
clinmedi-179	30	20	10	10	NUM
clinmedi-179	30	21	%	%	NOUN
clinmedi-179	30	22	of	of	ADP
clinmedi-179	30	23	tumor	tumor	NOUN
clinmedi-179	30	24	cells	cell	NOUN
clinmedi-179	30	25	,	,	PUNCT
clinmedi-179	30	26	or	or	CCONJ
clinmedi-179	30	27	her2	her2	PROPN
clinmedi-179	30	28	gene	gene	NOUN
clinmedi-179	30	29	was	be	AUX
clinmedi-179	30	30	regarded	regard	VERB
clinmedi-179	30	31	as	as	SCONJ
clinmedi-179	30	32	amplified	amplify	VERB
clinmedi-179	30	33	when	when	SCONJ
clinmedi-179	30	34	the	the	DET
clinmedi-179	30	35	her2	her2	PROPN
clinmedi-179	30	36	/	/	SYM
clinmedi-179	30	37	chromosome	chromosome	NOUN
clinmedi-179	30	38	enumeration	enumeration	NOUN
clinmedi-179	30	39	probe	probe	NOUN
clinmedi-179	30	40	17	17	NUM
clinmedi-179	30	41	(	(	PUNCT
clinmedi-179	30	42	cep17	cep17	NOUN
clinmedi-179	30	43	)	)	PUNCT
clinmedi-179	30	44	ratio	ratio	NOUN
clinmedi-179	30	45	was	be	AUX
clinmedi-179	30	46	>	>	X
clinmedi-179	30	47	2.0	2.0	NUM
clinmedi-179	30	48	in	in	ADP
clinmedi-179	30	49	a	a	DET
clinmedi-179	30	50	dual	dual	ADJ
clinmedi-179	30	51	-	-	PUNCT
clinmedi-179	30	52	probe	probe	NOUN
clinmedi-179	30	53	assay	assay	NOUN
clinmedi-179	30	54	by	by	ADP
clinmedi-179	30	55	fluorescence	fluorescence	NOUN
clinmedi-179	30	56	in	in	ADP
clinmedi-179	30	57	situ	situ	ADJ
clinmedi-179	30	58	hybridization	hybridization	NOUN
clinmedi-179	30	59	.	.	PUNCT
clinmedi-179	31	1	er	er	INTJ
clinmedi-179	31	2	and	and	CCONJ
clinmedi-179	31	3	pgr	pgr	PROPN
clinmedi-179	31	4	were	be	AUX
clinmedi-179	31	5	considered	consider	VERB
clinmedi-179	31	6	as	as	ADP
clinmedi-179	31	7	positive	positive	ADJ
clinmedi-179	31	8	when	when	SCONJ
clinmedi-179	31	9	immunohistochemical	immunohistochemical	ADJ
clinmedi-179	31	10	staining	staining	NOUN
clinmedi-179	31	11	showed	show	VERB
clinmedi-179	31	12	at	at	ADP
clinmedi-179	31	13	least	least	ADJ
clinmedi-179	31	14	1	1	NUM
clinmedi-179	31	15	%	%	NOUN
clinmedi-179	31	16	positivity	positivity	NOUN
clinmedi-179	31	17	.	.	PUNCT
clinmedi-179	32	1	cancer	cancer	NOUN
clinmedi-179	32	2	was	be	AUX
clinmedi-179	32	3	considered	consider	VERB
clinmedi-179	32	4	as	as	ADP
clinmedi-179	32	5	hormone	hormone	NOUN
clinmedi-179	32	6	receptor	receptor	NOUN
clinmedi-179	32	7	(	(	PUNCT
clinmedi-179	32	8	hr)-positive	hr)-positive	ADJ
clinmedi-179	32	9	when	when	SCONJ
clinmedi-179	32	10	either	either	CCONJ
clinmedi-179	32	11	er	er	INTJ
clinmedi-179	32	12	or	or	CCONJ
clinmedi-179	32	13	pgr	pgr	NOUN
clinmedi-179	32	14	was	be	AUX
clinmedi-179	32	15	positive	positive	ADJ
clinmedi-179	32	16	.	.	PUNCT
clinmedi-179	33	1	the	the	DET
clinmedi-179	33	2	patients	patient	NOUN
clinmedi-179	33	3	were	be	AUX
clinmedi-179	33	4	administered	administer	VERB
clinmedi-179	33	5	four	four	NUM
clinmedi-179	33	6	cycles	cycle	NOUN
clinmedi-179	33	7	of	of	ADP
clinmedi-179	33	8	nabptx	nabptx	NOUN
clinmedi-179	33	9	(	(	PUNCT
clinmedi-179	33	10	220	220	NUM
clinmedi-179	33	11	mg	mg	NUM
clinmedi-179	33	12	/	/	SYM
clinmedi-179	33	13	m	m	VERB
clinmedi-179	33	14	2	2	NUM
clinmedi-179	33	15	q3w	q3w	NOUN
clinmedi-179	33	16	)	)	PUNCT
clinmedi-179	33	17	,	,	PUNCT
clinmedi-179	33	18	followed	follow	VERB
clinmedi-179	33	19	by	by	ADP
clinmedi-179	33	20	four	four	NUM
clinmedi-179	33	21	cycles	cycle	NOUN
clinmedi-179	33	22	of	of	ADP
clinmedi-179	33	23	q3w	q3w	NOUN
clinmedi-179	33	24	fec	fec	PROPN
clinmedi-179	33	25	without	without	ADP
clinmedi-179	33	26	using	use	VERB
clinmedi-179	33	27	prophylactic	prophylactic	ADJ
clinmedi-179	33	28	granulocyte	granulocyte	NOUN
clinmedi-179	33	29	colony	colony	NOUN
clinmedi-179	33	30	-	-	PUNCT
clinmedi-179	33	31	stimulating	stimulate	VERB
clinmedi-179	33	32	factor	factor	NOUN
clinmedi-179	33	33	.	.	PUNCT
clinmedi-179	34	1	for	for	ADP
clinmedi-179	34	2	anti	anti	ADJ
clinmedi-179	34	3	-	-	ADJ
clinmedi-179	34	4	her2	her2	ADJ
clinmedi-179	34	5	treatment	treatment	NOUN
clinmedi-179	34	6	,	,	PUNCT
clinmedi-179	34	7	q3w	q3w	NOUN
clinmedi-179	34	8	trastuzumab	trastuzumab	NOUN
clinmedi-179	34	9	at	at	ADP
clinmedi-179	34	10	6	6	NUM
clinmedi-179	34	11	mg	mg	NOUN
clinmedi-179	34	12	/	/	SYM
clinmedi-179	34	13	kg	kg	PROPN
clinmedi-179	34	14	(	(	PUNCT
clinmedi-179	34	15	8	8	NUM
clinmedi-179	34	16	mg	mg	NUM
clinmedi-179	34	17	/	/	SYM
clinmedi-179	34	18	kg	kg	PROPN
clinmedi-179	34	19	as	as	ADP
clinmedi-179	34	20	the	the	DET
clinmedi-179	34	21	loading	loading	NOUN
clinmedi-179	34	22	dose	dose	NOUN
clinmedi-179	34	23	)	)	PUNCT
clinmedi-179	34	24	was	be	AUX
clinmedi-179	34	25	administered	administer	VERB
clinmedi-179	34	26	concurrently	concurrently	ADV
clinmedi-179	34	27	with	with	ADP
clinmedi-179	34	28	nab	nab	NOUN
clinmedi-179	34	29	-	-	PUNCT
clinmedi-179	34	30	ptx	ptx	NOUN
clinmedi-179	34	31	for	for	ADP
clinmedi-179	34	32	four	four	NUM
clinmedi-179	34	33	cycles	cycle	NOUN
clinmedi-179	34	34	.	.	PUNCT
clinmedi-179	35	1	in	in	ADP
clinmedi-179	35	2	addition	addition	NOUN
clinmedi-179	35	3	,	,	PUNCT
clinmedi-179	35	4	13	13	NUM
clinmedi-179	35	5	cycles	cycle	NOUN
clinmedi-179	35	6	of	of	ADP
clinmedi-179	35	7	trastuzumab	trastuzumab	NOUN
clinmedi-179	35	8	were	be	AUX
clinmedi-179	35	9	administered	administer	VERB
clinmedi-179	35	10	following	follow	VERB
clinmedi-179	35	11	the	the	DET
clinmedi-179	35	12	surgery	surgery	NOUN
clinmedi-179	35	13	.	.	PUNCT
clinmedi-179	36	1	toxicities	toxicity	NOUN
clinmedi-179	36	2	were	be	AUX
clinmedi-179	36	3	evaluated	evaluate	VERB
clinmedi-179	36	4	according	accord	VERB
clinmedi-179	36	5	to	to	ADP
clinmedi-179	36	6	the	the	DET
clinmedi-179	36	7	national	national	PROPN
clinmedi-179	36	8	cancer	cancer	PROPN
clinmedi-179	36	9	institute	institute	PROPN
clinmedi-179	36	10	common	common	ADJ
clinmedi-179	36	11	terminology	terminology	NOUN
clinmedi-179	36	12	criteria	criterion	NOUN
clinmedi-179	36	13	for	for	ADP
clinmedi-179	36	14	adverse	adverse	ADJ
clinmedi-179	36	15	events	event	NOUN
clinmedi-179	36	16	(	(	PUNCT
clinmedi-179	36	17	ctcae	ctcae	NOUN
clinmedi-179	36	18	)	)	PUNCT
clinmedi-179	36	19	version	version	NOUN
clinmedi-179	36	20	4.0	4.0	NUM
clinmedi-179	36	21	.	.	PUNCT
clinmedi-179	37	1	the	the	DET
clinmedi-179	37	2	protocol	protocol	NOUN
clinmedi-179	37	3	treatment	treatment	NOUN
clinmedi-179	37	4	was	be	AUX
clinmedi-179	37	5	discontinued	discontinue	VERB
clinmedi-179	37	6	upon	upon	SCONJ
clinmedi-179	37	7	observation	observation	NOUN
clinmedi-179	37	8	of	of	ADP
clinmedi-179	37	9	any	any	DET
clinmedi-179	37	10	adverse	adverse	ADJ
clinmedi-179	37	11	events	event	NOUN
clinmedi-179	37	12	such	such	ADJ
clinmedi-179	37	13	as	as	ADP
clinmedi-179	37	14	grade	grade	NOUN
clinmedi-179	37	15	4	4	NUM
clinmedi-179	37	16	non	non	ADJ
clinmedi-179	37	17	-	-	ADJ
clinmedi-179	37	18	hematologic	hematologic	ADJ
clinmedi-179	37	19	toxicity	toxicity	NOUN
clinmedi-179	37	20	,	,	PUNCT
clinmedi-179	37	21	progression	progression	NOUN
clinmedi-179	37	22	of	of	ADP
clinmedi-179	37	23	the	the	DET
clinmedi-179	37	24	primary	primary	ADJ
clinmedi-179	37	25	tumor	tumor	NOUN
clinmedi-179	37	26	,	,	PUNCT
clinmedi-179	37	27	or	or	CCONJ
clinmedi-179	37	28	lymph	lymph	NOUN
clinmedi-179	37	29	node	node	ADJ
clinmedi-179	37	30	metastasis	metastasis	NOUN
clinmedi-179	37	31	.	.	PUNCT
clinmedi-179	38	1	adjuvant	adjuvant	ADJ
clinmedi-179	38	2	systemic	systemic	ADJ
clinmedi-179	38	3	or	or	CCONJ
clinmedi-179	38	4	radiation	radiation	NOUN
clinmedi-179	38	5	therapy	therapy	NOUN
clinmedi-179	38	6	was	be	AUX
clinmedi-179	38	7	administered	administer	VERB
clinmedi-179	38	8	as	as	SCONJ
clinmedi-179	38	9	needed	need	VERB
clinmedi-179	38	10	.	.	PUNCT
clinmedi-179	39	1	this	this	DET
clinmedi-179	39	2	study	study	NOUN
clinmedi-179	39	3	was	be	AUX
clinmedi-179	39	4	approved	approve	VERB
clinmedi-179	39	5	by	by	ADP
clinmedi-179	39	6	the	the	DET
clinmedi-179	39	7	institutional	institutional	ADJ
clinmedi-179	39	8	review	review	PROPN
clinmedi-179	39	9	board	board	NOUN
clinmedi-179	39	10	of	of	ADP
clinmedi-179	39	11	the	the	DET
clinmedi-179	39	12	jikei	jikei	NOUN
clinmedi-179	39	13	university	university	PROPN
clinmedi-179	39	14	school	school	NOUN
clinmedi-179	39	15	of	of	ADP
clinmedi-179	39	16	medicine	medicine	NOUN
clinmedi-179	39	17	[	[	X
clinmedi-179	39	18	25	25	NUM
clinmedi-179	39	19	-	-	PUNCT
clinmedi-179	39	20	305(7440	305(7440	NUM
clinmedi-179	39	21	)	)	PUNCT
clinmedi-179	39	22	]	]	PUNCT
clinmedi-179	39	23	.	.	PUNCT
clinmedi-179	40	1	assessment	assessment	NOUN
clinmedi-179	40	2	the	the	DET
clinmedi-179	40	3	primary	primary	ADJ
clinmedi-179	40	4	endpoint	endpoint	NOUN
clinmedi-179	40	5	of	of	ADP
clinmedi-179	40	6	the	the	DET
clinmedi-179	40	7	nab	nab	ADJ
clinmedi-179	40	8	-	-	PUNCT
clinmedi-179	40	9	ptx220	ptx220	NOUN
clinmedi-179	40	10	study	study	NOUN
clinmedi-179	40	11	was	be	AUX
clinmedi-179	40	12	the	the	DET
clinmedi-179	40	13	pathological	pathological	ADJ
clinmedi-179	40	14	complete	complete	ADJ
clinmedi-179	40	15	response	response	NOUN
clinmedi-179	40	16	(	(	PUNCT
clinmedi-179	40	17	pcr	pcr	ADJ
clinmedi-179	40	18	)	)	PUNCT
clinmedi-179	40	19	rate	rate	NOUN
clinmedi-179	40	20	,	,	PUNCT
clinmedi-179	40	21	which	which	PRON
clinmedi-179	40	22	is	be	AUX
clinmedi-179	40	23	defined	define	VERB
clinmedi-179	40	24	as	as	ADP
clinmedi-179	40	25	the	the	DET
clinmedi-179	40	26	absence	absence	NOUN
clinmedi-179	40	27	of	of	ADP
clinmedi-179	40	28	histological	histological	ADJ
clinmedi-179	40	29	evidence	evidence	NOUN
clinmedi-179	40	30	of	of	ADP
clinmedi-179	40	31	residual	residual	ADJ
clinmedi-179	40	32	invasive	invasive	ADJ
clinmedi-179	40	33	tumor	tumor	NOUN
clinmedi-179	40	34	cells	cell	NOUN
clinmedi-179	40	35	in	in	ADP
clinmedi-179	40	36	the	the	DET
clinmedi-179	40	37	breast	breast	NOUN
clinmedi-179	40	38	and	and	CCONJ
clinmedi-179	40	39	axillary	axillary	ADJ
clinmedi-179	40	40	lymph	lymph	NOUN
clinmedi-179	40	41	nodes	node	NOUN
clinmedi-179	40	42	(	(	PUNCT
clinmedi-179	40	43	ypt0	ypt0	PROPN
clinmedi-179	40	44	/	/	SYM
clinmedi-179	40	45	tisypn0	tisypn0	PROPN
clinmedi-179	40	46	)	)	PUNCT
clinmedi-179	40	47	.	.	PUNCT
clinmedi-179	41	1	the	the	DET
clinmedi-179	41	2	secondary	secondary	ADJ
clinmedi-179	41	3	endpoint	endpoint	NOUN
clinmedi-179	41	4	was	be	AUX
clinmedi-179	41	5	toxicity	toxicity	NOUN
clinmedi-179	41	6	.	.	PUNCT
clinmedi-179	42	1	follow	follow	VERB
clinmedi-179	42	2	-	-	PUNCT
clinmedi-179	42	3	up	up	NOUN
clinmedi-179	42	4	all	all	DET
clinmedi-179	42	5	patients	patient	NOUN
clinmedi-179	42	6	were	be	AUX
clinmedi-179	42	7	followed	follow	VERB
clinmedi-179	42	8	up	up	ADP
clinmedi-179	42	9	for	for	ADP
clinmedi-179	42	10	at	at	ADV
clinmedi-179	42	11	least	least	ADV
clinmedi-179	42	12	36	36	NUM
clinmedi-179	42	13	months	month	NOUN
clinmedi-179	42	14	;	;	PUNCT
clinmedi-179	42	15	those	those	PRON
clinmedi-179	42	16	who	who	PRON
clinmedi-179	42	17	completed	complete	VERB
clinmedi-179	42	18	the	the	DET
clinmedi-179	42	19	treatment	treatment	NOUN
clinmedi-179	42	20	protocol	protocol	NOUN
clinmedi-179	42	21	and	and	CCONJ
clinmedi-179	42	22	underwent	underwent	ADJ
clinmedi-179	42	23	surgery	surgery	NOUN
clinmedi-179	42	24	(	(	PUNCT
clinmedi-179	42	25	n	n	NOUN
clinmedi-179	42	26	=	=	SYM
clinmedi-179	42	27	15	15	NUM
clinmedi-179	42	28	)	)	PUNCT
clinmedi-179	42	29	were	be	AUX
clinmedi-179	42	30	analyzed	analyze	VERB
clinmedi-179	42	31	for	for	ADP
clinmedi-179	42	32	long	long	ADJ
clinmedi-179	42	33	-	-	PUNCT
clinmedi-179	42	34	term	term	NOUN
clinmedi-179	42	35	follow	follow	NOUN
clinmedi-179	42	36	-	-	PUNCT
clinmedi-179	42	37	up	up	NOUN
clinmedi-179	42	38	.	.	PUNCT
clinmedi-179	43	1	relapse	relapse	NOUN
clinmedi-179	43	2	-	-	PUNCT
clinmedi-179	43	3	free	free	ADJ
clinmedi-179	43	4	survival	survival	NOUN
clinmedi-179	43	5	(	(	PUNCT
clinmedi-179	43	6	rfs	rfs	PROPN
clinmedi-179	43	7	)	)	PUNCT
clinmedi-179	43	8	was	be	AUX
clinmedi-179	43	9	calculated	calculate	VERB
clinmedi-179	43	10	as	as	ADP
clinmedi-179	43	11	the	the	DET
clinmedi-179	43	12	time	time	NOUN
clinmedi-179	43	13	interval	interval	NOUN
clinmedi-179	43	14	(	(	PUNCT
clinmedi-179	43	15	in	in	ADP
clinmedi-179	43	16	months	month	NOUN
clinmedi-179	43	17	)	)	PUNCT
clinmedi-179	43	18	between	between	ADP
clinmedi-179	43	19	the	the	DET
clinmedi-179	43	20	date	date	NOUN
clinmedi-179	43	21	of	of	ADP
clinmedi-179	43	22	enrollment	enrollment	NOUN
clinmedi-179	43	23	and	and	CCONJ
clinmedi-179	43	24	the	the	DET
clinmedi-179	43	25	first	first	ADJ
clinmedi-179	43	26	observation	observation	NOUN
clinmedi-179	43	27	of	of	ADP
clinmedi-179	43	28	tumor	tumor	NOUN
clinmedi-179	43	29	recurrence	recurrence	NOUN
clinmedi-179	43	30	(	(	PUNCT
clinmedi-179	43	31	metastatic	metastatic	ADJ
clinmedi-179	43	32	recurrence	recurrence	NOUN
clinmedi-179	43	33	,	,	PUNCT
clinmedi-179	43	34	local	local	ADJ
clinmedi-179	43	35	,	,	PUNCT
clinmedi-179	43	36	or	or	CCONJ
clinmedi-179	43	37	regional	regional	ADJ
clinmedi-179	43	38	relapse	relapse	NOUN
clinmedi-179	43	39	)	)	PUNCT
clinmedi-179	43	40	,	,	PUNCT
clinmedi-179	43	41	death	death	NOUN
clinmedi-179	43	42	,	,	PUNCT
clinmedi-179	43	43	or	or	CCONJ
clinmedi-179	43	44	last	last	ADJ
clinmedi-179	43	45	follow	follow	NOUN
clinmedi-179	43	46	-	-	PUNCT
clinmedi-179	43	47	up	up	NOUN
clinmedi-179	43	48	.	.	PUNCT
clinmedi-179	44	1	disease	disease	NOUN
clinmedi-179	44	2	-	-	PUNCT
clinmedi-179	44	3	free	free	ADJ
clinmedi-179	44	4	survival	survival	NOUN
clinmedi-179	44	5	(	(	PUNCT
clinmedi-179	44	6	dfs	dfs	PROPN
clinmedi-179	44	7	)	)	PUNCT
clinmedi-179	44	8	was	be	AUX
clinmedi-179	44	9	calculated	calculate	VERB
clinmedi-179	44	10	as	as	ADP
clinmedi-179	44	11	the	the	DET
clinmedi-179	44	12	time	time	NOUN
clinmedi-179	44	13	interval	interval	NOUN
clinmedi-179	44	14	(	(	PUNCT
clinmedi-179	44	15	in	in	ADP
clinmedi-179	44	16	months	month	NOUN
clinmedi-179	44	17	)	)	PUNCT
clinmedi-179	44	18	between	between	ADP
clinmedi-179	44	19	the	the	DET
clinmedi-179	44	20	date	date	NOUN
clinmedi-179	44	21	of	of	ADP
clinmedi-179	44	22	enrollment	enrollment	NOUN
clinmedi-179	44	23	and	and	CCONJ
clinmedi-179	44	24	the	the	DET
clinmedi-179	44	25	first	first	ADJ
clinmedi-179	44	26	observation	observation	NOUN
clinmedi-179	44	27	of	of	ADP
clinmedi-179	44	28	tumor	tumor	NOUN
clinmedi-179	44	29	recurrence	recurrence	NOUN
clinmedi-179	44	30	(	(	PUNCT
clinmedi-179	44	31	metastatic	metastatic	ADJ
clinmedi-179	44	32	cmi	cmi	NOUN
clinmedi-179	44	33	04	04	NUM
clinmedi-179	44	34	(	(	PUNCT
clinmedi-179	44	35	02	02	NUM
clinmedi-179	44	36	)	)	PUNCT
clinmedi-179	44	37	,	,	PUNCT
clinmedi-179	44	38	378−386	378−386	NUM
clinmedi-179	44	39	cmi	cmi	PROPN
clinmedi-179	44	40	journal	journal	PROPN
clinmedi-179	44	41	380	380	NUM
clinmedi-179	44	42	cmi	cmi	PROPN
clinmedi-179	44	43	journal	journal	PROPN
clinmedi-179	44	44	kazumi	kazumi	PROPN
clinmedi-179	44	45	kawase	kawase	PROPN
clinmedi-179	44	46	et	et	PROPN
clinmedi-179	44	47	al	al	PROPN
clinmedi-179	44	48	.	.	PROPN
clinmedi-179	44	49	recurrence	recurrence	NOUN
clinmedi-179	44	50	and	and	CCONJ
clinmedi-179	44	51	local	local	ADJ
clinmedi-179	44	52	or	or	CCONJ
clinmedi-179	44	53	regional	regional	ADJ
clinmedi-179	44	54	relapse	relapse	NOUN
clinmedi-179	44	55	)	)	PUNCT
clinmedi-179	44	56	,	,	PUNCT
clinmedi-179	44	57	any	any	DET
clinmedi-179	44	58	second	second	ADJ
clinmedi-179	44	59	malignancy	malignancy	NOUN
clinmedi-179	44	60	,	,	PUNCT
clinmedi-179	44	61	death	death	NOUN
clinmedi-179	44	62	,	,	PUNCT
clinmedi-179	44	63	or	or	CCONJ
clinmedi-179	44	64	last	last	ADJ
clinmedi-179	44	65	follow	follow	NOUN
clinmedi-179	44	66	-	-	PUNCT
clinmedi-179	44	67	up	up	NOUN
clinmedi-179	44	68	.	.	PUNCT
clinmedi-179	45	1	overall	overall	ADJ
clinmedi-179	45	2	survival	survival	NOUN
clinmedi-179	45	3	(	(	PUNCT
clinmedi-179	45	4	os	os	NOUN
clinmedi-179	45	5	)	)	PUNCT
clinmedi-179	45	6	was	be	AUX
clinmedi-179	45	7	calculated	calculate	VERB
clinmedi-179	45	8	as	as	ADP
clinmedi-179	45	9	the	the	DET
clinmedi-179	45	10	time	time	NOUN
clinmedi-179	45	11	interval	interval	NOUN
clinmedi-179	45	12	between	between	ADP
clinmedi-179	45	13	the	the	DET
clinmedi-179	45	14	date	date	NOUN
clinmedi-179	45	15	of	of	ADP
clinmedi-179	45	16	enrollment	enrollment	NOUN
clinmedi-179	45	17	and	and	CCONJ
clinmedi-179	45	18	death	death	NOUN
clinmedi-179	45	19	or	or	CCONJ
clinmedi-179	45	20	last	last	ADJ
clinmedi-179	45	21	follow	follow	NOUN
clinmedi-179	45	22	-	-	PUNCT
clinmedi-179	45	23	up	up	NOUN
clinmedi-179	45	24	.	.	PUNCT
clinmedi-179	46	1	this	this	DET
clinmedi-179	46	2	part	part	NOUN
clinmedi-179	46	3	was	be	AUX
clinmedi-179	46	4	approved	approve	VERB
clinmedi-179	46	5	separately	separately	ADV
clinmedi-179	46	6	as	as	ADP
clinmedi-179	46	7	observational	observational	ADJ
clinmedi-179	46	8	study	study	NOUN
clinmedi-179	46	9	by	by	ADP
clinmedi-179	46	10	the	the	DET
clinmedi-179	46	11	institutional	institutional	ADJ
clinmedi-179	46	12	review	review	PROPN
clinmedi-179	46	13	board	board	NOUN
clinmedi-179	46	14	of	of	ADP
clinmedi-179	46	15	the	the	DET
clinmedi-179	46	16	jikei	jikei	NOUN
clinmedi-179	46	17	university	university	PROPN
clinmedi-179	46	18	school	school	NOUN
clinmedi-179	46	19	of	of	ADP
clinmedi-179	46	20	medicine	medicine	NOUN
clinmedi-179	46	21	[	[	PUNCT
clinmedi-179	46	22	32	32	NUM
clinmedi-179	46	23	-	-	SYM
clinmedi-179	46	24	484(10577	484(10577	NUM
clinmedi-179	46	25	)	)	PUNCT
clinmedi-179	46	26	]	]	PUNCT
clinmedi-179	46	27	.	.	PUNCT
clinmedi-179	47	1	statistical	statistical	ADJ
clinmedi-179	47	2	analysis	analysis	NOUN
clinmedi-179	47	3	the	the	DET
clinmedi-179	47	4	pcr	pcr	ADJ
clinmedi-179	47	5	rates	rate	NOUN
clinmedi-179	47	6	of	of	ADP
clinmedi-179	47	7	previous	previous	ADJ
clinmedi-179	47	8	neoadjuvant	neoadjuvant	ADJ
clinmedi-179	47	9	trials	trial	NOUN
clinmedi-179	47	10	with	with	ADP
clinmedi-179	47	11	anthracycline	anthracycline	NOUN
clinmedi-179	47	12	/	/	SYM
clinmedi-179	47	13	taxane	taxane	NOUN
clinmedi-179	47	14	were	be	AUX
clinmedi-179	47	15	31.3%–65.2	31.3%–65.2	NOUN
clinmedi-179	47	16	%	%	NOUN
clinmedi-179	47	17	.	.	PUNCT
clinmedi-179	48	1	3	3	NUM
clinmedi-179	48	2	,	,	PUNCT
clinmedi-179	48	3	4	4	NUM
clinmedi-179	48	4	we	we	PRON
clinmedi-179	48	5	estimated	estimate	VERB
clinmedi-179	48	6	the	the	DET
clinmedi-179	48	7	required	require	VERB
clinmedi-179	48	8	sample	sample	NOUN
clinmedi-179	48	9	size	size	NOUN
clinmedi-179	48	10	of	of	ADP
clinmedi-179	48	11	17	17	NUM
clinmedi-179	48	12	by	by	ADP
clinmedi-179	48	13	setting	set	VERB
clinmedi-179	48	14	an	an	DET
clinmedi-179	48	15	efficacy	efficacy	NOUN
clinmedi-179	48	16	of	of	ADP
clinmedi-179	48	17	60	60	NUM
clinmedi-179	48	18	%	%	NOUN
clinmedi-179	48	19	,	,	PUNCT
clinmedi-179	48	20	threshold	threshold	NOUN
clinmedi-179	48	21	efficacy	efficacy	NOUN
clinmedi-179	48	22	of	of	ADP
clinmedi-179	48	23	35	35	NUM
clinmedi-179	48	24	%	%	NOUN
clinmedi-179	48	25	,	,	PUNCT
clinmedi-179	48	26	power	power	NOUN
clinmedi-179	48	27	of	of	ADP
clinmedi-179	48	28	80	80	NUM
clinmedi-179	48	29	%	%	NOUN
clinmedi-179	48	30	,	,	PUNCT
clinmedi-179	48	31	and	and	CCONJ
clinmedi-179	48	32	the	the	DET
clinmedi-179	48	33	alpha	alpha	ADJ
clinmedi-179	48	34	value	value	NOUN
clinmedi-179	48	35	of	of	ADP
clinmedi-179	48	36	0.1	0.1	NUM
clinmedi-179	48	37	%	%	NOUN
clinmedi-179	48	38	(	(	PUNCT
clinmedi-179	48	39	onesided	onesided	ADJ
clinmedi-179	48	40	)	)	PUNCT
clinmedi-179	48	41	using	use	VERB
clinmedi-179	48	42	the	the	DET
clinmedi-179	48	43	binomial	binomial	ADJ
clinmedi-179	48	44	test	test	NOUN
clinmedi-179	48	45	.	.	PUNCT
clinmedi-179	49	1	all	all	DET
clinmedi-179	49	2	analyses	analysis	NOUN
clinmedi-179	49	3	were	be	AUX
clinmedi-179	49	4	performed	perform	VERB
clinmedi-179	49	5	using	use	VERB
clinmedi-179	49	6	spss	spss	ADJ
clinmedi-179	49	7	statistical	statistical	ADJ
clinmedi-179	49	8	software	software	NOUN
clinmedi-179	49	9	version	version	NOUN
clinmedi-179	49	10	24.0	24.0	NUM
clinmedi-179	49	11	(	(	PUNCT
clinmedi-179	49	12	spss	spss	PROPN
clinmedi-179	49	13	,	,	PUNCT
clinmedi-179	49	14	inc	inc	PROPN
clinmedi-179	49	15	.	.	PROPN
clinmedi-179	49	16	,	,	PUNCT
clinmedi-179	49	17	chicago	chicago	PROPN
clinmedi-179	49	18	,	,	PUNCT
clinmedi-179	49	19	il	il	PROPN
clinmedi-179	49	20	,	,	PUNCT
clinmedi-179	49	21	usa	usa	PROPN
clinmedi-179	49	22	)	)	PUNCT
clinmedi-179	49	23	,	,	PUNCT
clinmedi-179	49	24	and	and	CCONJ
clinmedi-179	49	25	the	the	DET
clinmedi-179	49	26	significance	significance	NOUN
clinmedi-179	49	27	level	level	NOUN
clinmedi-179	49	28	for	for	ADP
clinmedi-179	49	29	a	a	DET
clinmedi-179	49	30	two	two	NUM
clinmedi-179	49	31	-	-	PUNCT
clinmedi-179	49	32	sided	sided	ADJ
clinmedi-179	49	33	test	test	NOUN
clinmedi-179	49	34	was	be	AUX
clinmedi-179	49	35	set	set	VERB
clinmedi-179	49	36	at	at	ADP
clinmedi-179	49	37	0.05	0.05	NUM
clinmedi-179	49	38	.	.	PUNCT
clinmedi-179	50	1	rfs	rfs	PROPN
clinmedi-179	50	2	and	and	CCONJ
clinmedi-179	50	3	os	os	NOUN
clinmedi-179	50	4	were	be	AUX
clinmedi-179	50	5	assessed	assess	VERB
clinmedi-179	50	6	using	use	VERB
clinmedi-179	50	7	kaplan	kaplan	PROPN
clinmedi-179	50	8	–	–	PUNCT
clinmedi-179	50	9	meier	meier	PROPN
clinmedi-179	50	10	estimates	estimate	VERB
clinmedi-179	50	11	,	,	PUNCT
clinmedi-179	50	12	and	and	CCONJ
clinmedi-179	50	13	sub	sub	NOUN
clinmedi-179	50	14	-	-	NOUN
clinmedi-179	50	15	groups	group	NOUN
clinmedi-179	50	16	were	be	AUX
clinmedi-179	50	17	analyzed	analyze	VERB
clinmedi-179	50	18	using	use	VERB
clinmedi-179	50	19	the	the	DET
clinmedi-179	50	20	log	log	NOUN
clinmedi-179	50	21	-	-	PUNCT
clinmedi-179	50	22	rank	rank	NOUN
clinmedi-179	50	23	test	test	NOUN
clinmedi-179	50	24	.	.	PUNCT
clinmedi-179	51	1	results	result	VERB
clinmedi-179	51	2	patient	patient	ADJ
clinmedi-179	51	3	characteristics	characteristic	NOUN
clinmedi-179	51	4	twenty	twenty	NUM
clinmedi-179	51	5	patients	patient	NOUN
clinmedi-179	51	6	were	be	AUX
clinmedi-179	51	7	enrolled	enrol	VERB
clinmedi-179	51	8	in	in	ADP
clinmedi-179	51	9	this	this	DET
clinmedi-179	51	10	study	study	NOUN
clinmedi-179	51	11	.	.	PUNCT
clinmedi-179	52	1	the	the	DET
clinmedi-179	52	2	patient	patient	ADJ
clinmedi-179	52	3	and	and	CCONJ
clinmedi-179	52	4	tumor	tumor	NOUN
clinmedi-179	52	5	characteristics	characteristic	NOUN
clinmedi-179	52	6	are	be	AUX
clinmedi-179	52	7	presented	present	VERB
clinmedi-179	52	8	in	in	ADP
clinmedi-179	52	9	table	table	NOUN
clinmedi-179	52	10	1	1	NUM
clinmedi-179	52	11	.	.	PUNCT
clinmedi-179	52	12	table	table	NOUN
clinmedi-179	52	13	1	1	NUM
clinmedi-179	52	14	.	.	PUNCT
clinmedi-179	52	15	patient	patient	ADJ
clinmedi-179	52	16	and	and	CCONJ
clinmedi-179	52	17	tumor	tumor	NOUN
clinmedi-179	52	18	characteristics	characteristic	NOUN
clinmedi-179	52	19	characteristic	characteristic	ADJ
clinmedi-179	52	20	n	n	CCONJ
clinmedi-179	52	21	(	(	PUNCT
clinmedi-179	52	22	%	%	INTJ
clinmedi-179	52	23	)	)	PUNCT
clinmedi-179	52	24	number	number	NOUN
clinmedi-179	52	25	of	of	ADP
clinmedi-179	52	26	patients	patient	NOUN
clinmedi-179	52	27	20	20	NUM
clinmedi-179	52	28	(	(	PUNCT
clinmedi-179	52	29	100.0	100.0	NUM
clinmedi-179	52	30	)	)	PUNCT
clinmedi-179	52	31	median	median	ADJ
clinmedi-179	52	32	age	age	NOUN
clinmedi-179	52	33	(	(	PUNCT
clinmedi-179	52	34	range	range	NOUN
clinmedi-179	52	35	)	)	PUNCT
clinmedi-179	52	36	,	,	PUNCT
clinmedi-179	52	37	years	year	NOUN
clinmedi-179	52	38	61.5	61.5	NUM
clinmedi-179	52	39	(	(	PUNCT
clinmedi-179	52	40	36–77	36–77	NUM
clinmedi-179	52	41	)	)	PUNCT
clinmedi-179	52	42	ps	ps	NOUN
clinmedi-179	52	43	0	0	NUM
clinmedi-179	52	44	1	1	NUM
clinmedi-179	52	45	13	13	NUM
clinmedi-179	52	46	(	(	PUNCT
clinmedi-179	52	47	65.0	65.0	NUM
clinmedi-179	52	48	)	)	PUNCT
clinmedi-179	52	49	7	7	NUM
clinmedi-179	52	50	(	(	PUNCT
clinmedi-179	52	51	35.0	35.0	NUM
clinmedi-179	52	52	)	)	PUNCT
clinmedi-179	52	53	ct	ct	NOUN
clinmedi-179	53	1	1	1	NUM
clinmedi-179	53	2	2	2	NUM
clinmedi-179	53	3	3	3	NUM
clinmedi-179	53	4	2	2	NUM
clinmedi-179	53	5	(	(	PUNCT
clinmedi-179	53	6	10.0	10.0	NUM
clinmedi-179	53	7	)	)	PUNCT
clinmedi-179	53	8	15	15	NUM
clinmedi-179	53	9	(	(	PUNCT
clinmedi-179	53	10	75.0	75.0	NUM
clinmedi-179	53	11	)	)	PUNCT
clinmedi-179	53	12	3	3	NUM
clinmedi-179	53	13	(	(	PUNCT
clinmedi-179	53	14	15.0	15.0	NUM
clinmedi-179	53	15	)	)	PUNCT
clinmedi-179	53	16	cn	cn	NOUN
clinmedi-179	53	17	0	0	NUM
clinmedi-179	53	18	1	1	NUM
clinmedi-179	53	19	2	2	NUM
clinmedi-179	53	20	8	8	NUM
clinmedi-179	53	21	(	(	PUNCT
clinmedi-179	53	22	40.0	40.0	NUM
clinmedi-179	53	23	)	)	PUNCT
clinmedi-179	53	24	9	9	NUM
clinmedi-179	53	25	(	(	PUNCT
clinmedi-179	53	26	45.0	45.0	NUM
clinmedi-179	53	27	)	)	PUNCT
clinmedi-179	53	28	3	3	NUM
clinmedi-179	53	29	(	(	PUNCT
clinmedi-179	53	30	15.0	15.0	NUM
clinmedi-179	53	31	)	)	PUNCT
clinmedi-179	53	32	stage	stage	NOUN
clinmedi-179	54	1	i	i	NOUN
clinmedi-179	54	2	ii	ii	VERB
clinmedi-179	54	3	iii	iii	NUM
clinmedi-179	54	4	1	1	NUM
clinmedi-179	54	5	(	(	PUNCT
clinmedi-179	54	6	5.0	5.0	NUM
clinmedi-179	54	7	)	)	PUNCT
clinmedi-179	54	8	15	15	NUM
clinmedi-179	54	9	(	(	PUNCT
clinmedi-179	54	10	75.0	75.0	NUM
clinmedi-179	54	11	)	)	SYM
clinmedi-179	54	12	4	4	NUM
clinmedi-179	54	13	(	(	PUNCT
clinmedi-179	54	14	20.0	20.0	NUM
clinmedi-179	54	15	)	)	PUNCT
clinmedi-179	54	16	histology	histology	NOUN
clinmedi-179	54	17	invasive	invasive	ADJ
clinmedi-179	54	18	ductal	ductal	ADJ
clinmedi-179	54	19	carcinoma	carcinoma	NOUN
clinmedi-179	54	20	20	20	NUM
clinmedi-179	54	21	(	(	PUNCT
clinmedi-179	54	22	100.0	100.0	NUM
clinmedi-179	54	23	)	)	PUNCT
clinmedi-179	54	24	er	er	INTJ
clinmedi-179	54	25	negative	negative	ADJ
clinmedi-179	54	26	(	(	PUNCT
clinmedi-179	54	27	<	<	NOUN
clinmedi-179	54	28	1	1	NUM
clinmedi-179	54	29	%	%	NOUN
clinmedi-179	54	30	)	)	PUNCT
clinmedi-179	54	31	positive	positive	ADJ
clinmedi-179	54	32	(	(	PUNCT
clinmedi-179	54	33	≥1	≥1	NUM
clinmedi-179	54	34	%	%	NOUN
clinmedi-179	54	35	)	)	PUNCT
clinmedi-179	54	36	8	8	NUM
clinmedi-179	54	37	(	(	PUNCT
clinmedi-179	54	38	40.0	40.0	NUM
clinmedi-179	54	39	)	)	PUNCT
clinmedi-179	54	40	12	12	NUM
clinmedi-179	54	41	(	(	PUNCT
clinmedi-179	54	42	60.0	60.0	NUM
clinmedi-179	54	43	)	)	PUNCT
clinmedi-179	54	44	pgr	pgr	NOUN
clinmedi-179	54	45	negative	negative	ADJ
clinmedi-179	54	46	(	(	PUNCT
clinmedi-179	54	47	<	<	NOUN
clinmedi-179	54	48	1	1	NUM
clinmedi-179	54	49	%	%	NOUN
clinmedi-179	54	50	)	)	PUNCT
clinmedi-179	54	51	positive	positive	ADJ
clinmedi-179	54	52	(	(	PUNCT
clinmedi-179	54	53	≥1	≥1	NUM
clinmedi-179	54	54	%	%	NOUN
clinmedi-179	54	55	)	)	PUNCT
clinmedi-179	54	56	12	12	NUM
clinmedi-179	54	57	(	(	PUNCT
clinmedi-179	54	58	60.0	60.0	NUM
clinmedi-179	54	59	)	)	SYM
clinmedi-179	54	60	8	8	NUM
clinmedi-179	54	61	(	(	PUNCT
clinmedi-179	54	62	40.0	40.0	NUM
clinmedi-179	54	63	)	)	PUNCT
clinmedi-179	54	64	subtype	subtype	NOUN
clinmedi-179	54	65	hr	hr	NOUN
clinmedi-179	54	66	+	+	CCONJ
clinmedi-179	54	67	hr	hr	NOUN
clinmedi-179	54	68	–	–	PUNCT
clinmedi-179	54	69	9	9	NUM
clinmedi-179	54	70	(	(	PUNCT
clinmedi-179	54	71	45.0	45.0	NUM
clinmedi-179	54	72	)	)	PUNCT
clinmedi-179	54	73	11	11	NUM
clinmedi-179	54	74	(	(	PUNCT
clinmedi-179	54	75	55.0	55.0	NUM
clinmedi-179	54	76	)	)	PUNCT
clinmedi-179	54	77	ps	ps	PROPN
clinmedi-179	54	78	,	,	PUNCT
clinmedi-179	54	79	performance	performance	NOUN
clinmedi-179	54	80	status	status	NOUN
clinmedi-179	54	81	;	;	PUNCT
clinmedi-179	54	82	ct	ct	X
clinmedi-179	54	83	,	,	PUNCT
clinmedi-179	54	84	clinical	clinical	ADJ
clinmedi-179	54	85	t	t	NOUN
clinmedi-179	54	86	stage	stage	NOUN
clinmedi-179	54	87	;	;	PUNCT
clinmedi-179	54	88	cn	cn	ADJ
clinmedi-179	54	89	,	,	PUNCT
clinmedi-179	54	90	clinical	clinical	ADJ
clinmedi-179	54	91	n	n	PRON
clinmedi-179	54	92	stage	stage	NOUN
clinmedi-179	54	93	;	;	PUNCT
clinmedi-179	54	94	er	er	INTJ
clinmedi-179	54	95	,	,	PUNCT
clinmedi-179	54	96	estrogen	estrogen	NOUN
clinmedi-179	54	97	receptor	receptor	NOUN
clinmedi-179	54	98	;	;	PUNCT
clinmedi-179	54	99	pgr	pgr	NOUN
clinmedi-179	54	100	,	,	PUNCT
clinmedi-179	54	101	progesterone	progesterone	NOUN
clinmedi-179	54	102	receptor	receptor	NOUN
clinmedi-179	54	103	;	;	PUNCT
clinmedi-179	54	104	hr	hr	NOUN
clinmedi-179	54	105	,	,	PUNCT
clinmedi-179	54	106	hormone	hormone	NOUN
clinmedi-179	54	107	receptor	receptor	NOUN
clinmedi-179	54	108	cmi	cmi	NOUN
clinmedi-179	54	109	04	04	NUM
clinmedi-179	54	110	(	(	PUNCT
clinmedi-179	54	111	02	02	NUM
clinmedi-179	54	112	)	)	PUNCT
clinmedi-179	54	113	,	,	PUNCT
clinmedi-179	54	114	378−386	378−386	NUM
clinmedi-179	54	115	cmi	cmi	PROPN
clinmedi-179	54	116	journal	journal	NOUN
clinmedi-179	54	117	381	381	NUM
clinmedi-179	54	118	cmi	cmi	PROPN
clinmedi-179	54	119	journal	journal	PROPN
clinmedi-179	54	120	kazumi	kazumi	PROPN
clinmedi-179	54	121	kawase	kawase	PROPN
clinmedi-179	54	122	et	et	PROPN
clinmedi-179	54	123	al	al	PROPN
clinmedi-179	54	124	.	.	PUNCT
clinmedi-179	55	1	the	the	DET
clinmedi-179	55	2	median	median	ADJ
clinmedi-179	55	3	age	age	NOUN
clinmedi-179	55	4	was	be	AUX
clinmedi-179	55	5	61.5	61.5	NUM
clinmedi-179	55	6	(	(	PUNCT
clinmedi-179	55	7	36–77	36–77	NUM
clinmedi-179	55	8	)	)	PUNCT
clinmedi-179	55	9	years	year	NOUN
clinmedi-179	55	10	.	.	PUNCT
clinmedi-179	56	1	most	most	ADJ
clinmedi-179	56	2	patients	patient	NOUN
clinmedi-179	56	3	had	have	VERB
clinmedi-179	56	4	stage	stage	NOUN
clinmedi-179	56	5	ii	ii	PROPN
clinmedi-179	56	6	or	or	CCONJ
clinmedi-179	56	7	iii	iii	NUM
clinmedi-179	56	8	disease	disease	NOUN
clinmedi-179	56	9	,	,	PUNCT
clinmedi-179	56	10	60.0	60.0	NUM
clinmedi-179	56	11	%	%	NOUN
clinmedi-179	56	12	of	of	ADP
clinmedi-179	56	13	patients	patient	NOUN
clinmedi-179	56	14	had	have	VERB
clinmedi-179	56	15	clinically	clinically	ADV
clinmedi-179	56	16	positive	positive	ADJ
clinmedi-179	56	17	nodes	node	NOUN
clinmedi-179	56	18	at	at	ADP
clinmedi-179	56	19	the	the	DET
clinmedi-179	56	20	initiation	initiation	NOUN
clinmedi-179	56	21	of	of	ADP
clinmedi-179	56	22	chemotherapy	chemotherapy	NOUN
clinmedi-179	56	23	,	,	PUNCT
clinmedi-179	56	24	and	and	CCONJ
clinmedi-179	56	25	45	45	NUM
clinmedi-179	56	26	%	%	NOUN
clinmedi-179	56	27	were	be	AUX
clinmedi-179	56	28	hr	hr	NOUN
clinmedi-179	56	29	+	+	X
clinmedi-179	56	30	.	.	PUNCT
clinmedi-179	57	1	regarding	regard	VERB
clinmedi-179	57	2	histology	histology	NOUN
clinmedi-179	57	3	,	,	PUNCT
clinmedi-179	57	4	all	all	DET
clinmedi-179	57	5	patients	patient	NOUN
clinmedi-179	57	6	presented	present	VERB
clinmedi-179	57	7	with	with	ADP
clinmedi-179	57	8	invasive	invasive	ADJ
clinmedi-179	57	9	ductal	ductal	ADJ
clinmedi-179	57	10	carcinoma	carcinoma	NOUN
clinmedi-179	57	11	.	.	PUNCT
clinmedi-179	58	1	outcomes	outcome	NOUN
clinmedi-179	58	2	during	during	ADP
clinmedi-179	58	3	the	the	DET
clinmedi-179	58	4	study	study	NOUN
clinmedi-179	58	5	,	,	PUNCT
clinmedi-179	58	6	four	four	NUM
clinmedi-179	58	7	patients	patient	NOUN
clinmedi-179	58	8	discontinued	discontinue	VERB
clinmedi-179	58	9	the	the	DET
clinmedi-179	58	10	treatment	treatment	NOUN
clinmedi-179	58	11	protocol	protocol	NOUN
clinmedi-179	58	12	(	(	PUNCT
clinmedi-179	58	13	patient	patient	ADJ
clinmedi-179	58	14	decision	decision	NOUN
clinmedi-179	58	15	,	,	PUNCT
clinmedi-179	58	16	n	n	NOUN
clinmedi-179	58	17	=	=	SYM
clinmedi-179	58	18	3	3	NUM
clinmedi-179	58	19	;	;	PUNCT
clinmedi-179	58	20	liver	liver	NOUN
clinmedi-179	58	21	dysfunction	dysfunction	NOUN
clinmedi-179	58	22	,	,	PUNCT
clinmedi-179	58	23	n	n	NOUN
clinmedi-179	58	24	=	=	SYM
clinmedi-179	58	25	1	1	NUM
clinmedi-179	58	26	)	)	PUNCT
clinmedi-179	58	27	.	.	PUNCT
clinmedi-179	59	1	in	in	ADP
clinmedi-179	59	2	total	total	ADJ
clinmedi-179	59	3	,	,	PUNCT
clinmedi-179	59	4	16	16	NUM
clinmedi-179	59	5	patients	patient	NOUN
clinmedi-179	59	6	completed	complete	VERB
clinmedi-179	59	7	the	the	DET
clinmedi-179	59	8	protocol	protocol	NOUN
clinmedi-179	59	9	treatment	treatment	NOUN
clinmedi-179	59	10	,	,	PUNCT
clinmedi-179	59	11	one	one	NUM
clinmedi-179	59	12	of	of	ADP
clinmedi-179	59	13	whom	whom	PRON
clinmedi-179	59	14	violated	violate	VERB
clinmedi-179	59	15	the	the	DET
clinmedi-179	59	16	protocol	protocol	NOUN
clinmedi-179	59	17	(	(	PUNCT
clinmedi-179	59	18	use	use	NOUN
clinmedi-179	59	19	of	of	ADP
clinmedi-179	59	20	prophylactic	prophylactic	ADJ
clinmedi-179	59	21	granulocyte	granulocyte	NOUN
clinmedi-179	59	22	colonystimulating	colonystimulate	VERB
clinmedi-179	59	23	factor	factor	NOUN
clinmedi-179	59	24	)	)	PUNCT
clinmedi-179	59	25	.	.	PUNCT
clinmedi-179	60	1	therefore	therefore	ADV
clinmedi-179	60	2	,	,	PUNCT
clinmedi-179	60	3	we	we	PRON
clinmedi-179	60	4	assessed	assess	VERB
clinmedi-179	60	5	all	all	DET
clinmedi-179	60	6	patients	patient	NOUN
clinmedi-179	60	7	who	who	PRON
clinmedi-179	60	8	underwent	undergo	VERB
clinmedi-179	60	9	surgery	surgery	NOUN
clinmedi-179	60	10	(	(	PUNCT
clinmedi-179	60	11	n	n	NOUN
clinmedi-179	60	12	=	=	NUM
clinmedi-179	60	13	20	20	NUM
clinmedi-179	60	14	)	)	PUNCT
clinmedi-179	60	15	as	as	ADP
clinmedi-179	60	16	the	the	DET
clinmedi-179	60	17	intention	intention	NOUN
clinmedi-179	60	18	-	-	PUNCT
clinmedi-179	60	19	to	to	ADP
clinmedi-179	60	20	-	-	PUNCT
clinmedi-179	60	21	treat	treat	VERB
clinmedi-179	60	22	group	group	NOUN
clinmedi-179	60	23	and	and	CCONJ
clinmedi-179	60	24	those	those	PRON
clinmedi-179	60	25	who	who	PRON
clinmedi-179	60	26	completed	complete	VERB
clinmedi-179	60	27	the	the	DET
clinmedi-179	60	28	protocol	protocol	NOUN
clinmedi-179	60	29	(	(	PUNCT
clinmedi-179	60	30	n	n	NOUN
clinmedi-179	60	31	=	=	SYM
clinmedi-179	60	32	15	15	NUM
clinmedi-179	60	33	)	)	PUNCT
clinmedi-179	60	34	as	as	ADP
clinmedi-179	60	35	the	the	DET
clinmedi-179	60	36	completed	complete	VERB
clinmedi-179	60	37	protocol	protocol	NOUN
clinmedi-179	60	38	treatment	treatment	NOUN
clinmedi-179	60	39	group	group	NOUN
clinmedi-179	60	40	(	(	PUNCT
clinmedi-179	60	41	fig	fig	NOUN
clinmedi-179	60	42	.	.	PUNCT
clinmedi-179	60	43	1	1	NUM
clinmedi-179	60	44	)	)	PUNCT
clinmedi-179	60	45	.	.	PUNCT
clinmedi-179	61	1	figure	figure	NOUN
clinmedi-179	61	2	1	1	NUM
clinmedi-179	61	3	.	.	PUNCT
clinmedi-179	61	4	study	study	NOUN
clinmedi-179	61	5	flow	flow	NOUN
clinmedi-179	61	6	chart	chart	NOUN
clinmedi-179	61	7	.	.	PUNCT
clinmedi-179	62	1	er	er	INTJ
clinmedi-179	62	2	,	,	PUNCT
clinmedi-179	62	3	estrogen	estrogen	NOUN
clinmedi-179	62	4	receptor	receptor	NOUN
clinmedi-179	62	5	;	;	PUNCT
clinmedi-179	62	6	pgr	pgr	NOUN
clinmedi-179	62	7	,	,	PUNCT
clinmedi-179	62	8	progesterone	progesterone	NOUN
clinmedi-179	62	9	receptor	receptor	NOUN
clinmedi-179	62	10	;	;	PUNCT
clinmedi-179	62	11	her2	her2	PROPN
clinmedi-179	62	12	,	,	PUNCT
clinmedi-179	62	13	human	human	ADJ
clinmedi-179	62	14	epidermal	epidermal	ADJ
clinmedi-179	62	15	growth	growth	NOUN
clinmedi-179	62	16	factor	factor	NOUN
clinmedi-179	62	17	receptor	receptor	NOUN
clinmedi-179	62	18	2	2	NUM
clinmedi-179	62	19	;	;	PUNCT
clinmedi-179	62	20	hbv	hbv	NOUN
clinmedi-179	62	21	,	,	PUNCT
clinmedi-179	62	22	hepatitis	hepatitis	PROPN
clinmedi-179	62	23	b	b	PROPN
clinmedi-179	62	24	virus	virus	NOUN
clinmedi-179	62	25	infection	infection	NOUN
clinmedi-179	62	26	;	;	PUNCT
clinmedi-179	62	27	ptx	ptx	NOUN
clinmedi-179	62	28	,	,	PUNCT
clinmedi-179	62	29	paclitaxel	paclitaxel	NOUN
clinmedi-179	62	30	;	;	PUNCT
clinmedi-179	62	31	nab	nab	NOUN
clinmedi-179	62	32	-	-	PUNCT
clinmedi-179	62	33	ptx	ptx	NOUN
clinmedi-179	62	34	,	,	PUNCT
clinmedi-179	62	35	nanoparticle	nanoparticle	NOUN
clinmedi-179	62	36	albumin	albumin	NOUN
clinmedi-179	62	37	-	-	PUNCT
clinmedi-179	62	38	bound	bind	VERB
clinmedi-179	62	39	paclitaxel	paclitaxel	NOUN
clinmedi-179	62	40	;	;	PUNCT
clinmedi-179	62	41	fec	fec	PROPN
clinmedi-179	62	42	,	,	PUNCT
clinmedi-179	62	43	fluorouracil	fluorouracil	NOUN
clinmedi-179	62	44	,	,	PUNCT
clinmedi-179	62	45	epirubicin	epirubicin	ADV
clinmedi-179	62	46	,	,	PUNCT
clinmedi-179	62	47	and	and	CCONJ
clinmedi-179	62	48	cyclophosphamide	cyclophosphamide	NOUN
clinmedi-179	62	49	;	;	PUNCT
clinmedi-179	62	50	gcsf	gcsf	NOUN
clinmedi-179	62	51	,	,	PUNCT
clinmedi-179	62	52	granulocyte	granulocyte	ADJ
clinmedi-179	62	53	colony	colony	NOUN
clinmedi-179	62	54	-	-	PUNCT
clinmedi-179	62	55	stimulating	stimulate	VERB
clinmedi-179	62	56	factor	factor	NOUN
clinmedi-179	62	57	.	.	PUNCT
clinmedi-179	63	1	operative	operative	ADJ
clinmedi-179	63	2	procedures	procedure	NOUN
clinmedi-179	63	3	and	and	CCONJ
clinmedi-179	63	4	pathological	pathological	ADJ
clinmedi-179	63	5	responses	response	NOUN
clinmedi-179	63	6	among	among	ADP
clinmedi-179	63	7	patients	patient	NOUN
clinmedi-179	63	8	who	who	PRON
clinmedi-179	63	9	underwent	undergo	VERB
clinmedi-179	63	10	surgery	surgery	NOUN
clinmedi-179	63	11	following	follow	VERB
clinmedi-179	63	12	completion	completion	NOUN
clinmedi-179	63	13	of	of	ADP
clinmedi-179	63	14	the	the	DET
clinmedi-179	63	15	treatment	treatment	NOUN
clinmedi-179	63	16	protocol	protocol	NOUN
clinmedi-179	63	17	are	be	AUX
clinmedi-179	63	18	presented	present	VERB
clinmedi-179	63	19	in	in	ADP
clinmedi-179	63	20	table	table	NOUN
clinmedi-179	63	21	2	2	NUM
clinmedi-179	63	22	.	.	PUNCT
clinmedi-179	64	1	cmi	cmi	PROPN
clinmedi-179	64	2	04	04	PROPN
clinmedi-179	64	3	(	(	PUNCT
clinmedi-179	64	4	02	02	NUM
clinmedi-179	64	5	)	)	PUNCT
clinmedi-179	64	6	,	,	PUNCT
clinmedi-179	64	7	378−386	378−386	NUM
clinmedi-179	64	8	cmi	cmi	PROPN
clinmedi-179	64	9	journal	journal	NOUN
clinmedi-179	64	10	382	382	NUM
clinmedi-179	64	11	cmi	cmi	PROPN
clinmedi-179	64	12	journal	journal	PROPN
clinmedi-179	64	13	kazumi	kazumi	PROPN
clinmedi-179	64	14	kawase	kawase	PROPN
clinmedi-179	64	15	et	et	PROPN
clinmedi-179	64	16	al	al	PROPN
clinmedi-179	64	17	.	.	PROPN
clinmedi-179	64	18	table	table	PROPN
clinmedi-179	64	19	2	2	NUM
clinmedi-179	64	20	.	.	PUNCT
clinmedi-179	64	21	surgical	surgical	ADJ
clinmedi-179	64	22	procedure	procedure	NOUN
clinmedi-179	64	23	and	and	CCONJ
clinmedi-179	64	24	pathological	pathological	ADJ
clinmedi-179	64	25	response	response	NOUN
clinmedi-179	64	26	cpt	cpt	PROPN
clinmedi-179	64	27	,	,	PUNCT
clinmedi-179	64	28	completed	complete	VERB
clinmedi-179	64	29	protocol	protocol	NOUN
clinmedi-179	64	30	treatment	treatment	NOUN
clinmedi-179	64	31	;	;	PUNCT
clinmedi-179	64	32	itt	itt	VERB
clinmedi-179	64	33	,	,	PUNCT
clinmedi-179	64	34	intention	intention	NOUN
clinmedi-179	64	35	-	-	PUNCT
clinmedi-179	64	36	to	to	ADP
clinmedi-179	64	37	-	-	PUNCT
clinmedi-179	64	38	treat	treat	NOUN
clinmedi-179	64	39	;	;	PUNCT
clinmedi-179	64	40	bp	bp	PROPN
clinmedi-179	64	41	,	,	PUNCT
clinmedi-179	64	42	partial	partial	ADJ
clinmedi-179	64	43	mastectomy	mastectomy	NOUN
clinmedi-179	64	44	;	;	PUNCT
clinmedi-179	64	45	bt	bt	ADJ
clinmedi-179	64	46	,	,	PUNCT
clinmedi-179	64	47	total	total	ADJ
clinmedi-179	64	48	mastectomy	mastectomy	NOUN
clinmedi-179	64	49	;	;	PUNCT
clinmedi-179	64	50	sn	sn	PROPN
clinmedi-179	64	51	,	,	PUNCT
clinmedi-179	64	52	sentinel	sentinel	ADJ
clinmedi-179	64	53	lymph	lymph	NOUN
clinmedi-179	64	54	node	node	PROPN
clinmedi-179	64	55	biopsy	biopsy	NOUN
clinmedi-179	64	56	;	;	PUNCT
clinmedi-179	64	57	ax	ax	NOUN
clinmedi-179	64	58	,	,	PUNCT
clinmedi-179	64	59	axillary	axillary	ADJ
clinmedi-179	64	60	lymph	lymph	NOUN
clinmedi-179	64	61	node	node	NOUN
clinmedi-179	64	62	dissection	dissection	NOUN
clinmedi-179	64	63	in	in	ADP
clinmedi-179	64	64	total	total	ADJ
clinmedi-179	64	65	,	,	PUNCT
clinmedi-179	64	66	60.0	60.0	NUM
clinmedi-179	64	67	%	%	NOUN
clinmedi-179	64	68	of	of	ADP
clinmedi-179	64	69	the	the	DET
clinmedi-179	64	70	patients	patient	NOUN
clinmedi-179	64	71	achieved	achieve	VERB
clinmedi-179	64	72	pcr	pcr	PROPN
clinmedi-179	64	73	,	,	PUNCT
clinmedi-179	64	74	with	with	ADP
clinmedi-179	64	75	37.5	37.5	NUM
clinmedi-179	64	76	%	%	NOUN
clinmedi-179	64	77	of	of	ADP
clinmedi-179	64	78	hr	hr	NOUN
clinmedi-179	64	79	+	+	CCONJ
clinmedi-179	64	80	patients	patient	NOUN
clinmedi-179	64	81	and	and	CCONJ
clinmedi-179	64	82	85.7	85.7	NUM
clinmedi-179	64	83	%	%	NOUN
clinmedi-179	64	84	of	of	ADP
clinmedi-179	64	85	hr	hr	NOUN
clinmedi-179	64	86	–	–	PUNCT
clinmedi-179	64	87	patients	patient	NOUN
clinmedi-179	64	88	achieving	achieve	VERB
clinmedi-179	64	89	pcr	pcr	NOUN
clinmedi-179	64	90	(	(	PUNCT
clinmedi-179	64	91	table	table	NOUN
clinmedi-179	64	92	3	3	NUM
clinmedi-179	64	93	)	)	PUNCT
clinmedi-179	64	94	.	.	PUNCT
clinmedi-179	65	1	table	table	NOUN
clinmedi-179	65	2	3	3	NUM
clinmedi-179	65	3	.	.	PUNCT
clinmedi-179	65	4	tumor	tumor	NOUN
clinmedi-179	65	5	subtype	subtype	NOUN
clinmedi-179	65	6	and	and	CCONJ
clinmedi-179	65	7	pathological	pathological	ADJ
clinmedi-179	65	8	response	response	NOUN
clinmedi-179	65	9	pcr	pcr	NOUN
clinmedi-179	65	10	,	,	PUNCT
clinmedi-179	65	11	pathological	pathological	ADJ
clinmedi-179	65	12	complete	complete	ADJ
clinmedi-179	65	13	response	response	NOUN
clinmedi-179	65	14	;	;	PUNCT
clinmedi-179	65	15	hr	hr	NOUN
clinmedi-179	65	16	,	,	PUNCT
clinmedi-179	65	17	hormone	hormone	NOUN
clinmedi-179	65	18	receptor	receptor	NOUN
clinmedi-179	65	19	at	at	ADP
clinmedi-179	65	20	36	36	NUM
clinmedi-179	65	21	months	month	NOUN
clinmedi-179	65	22	following	follow	VERB
clinmedi-179	65	23	study	study	NOUN
clinmedi-179	65	24	enrollment	enrollment	NOUN
clinmedi-179	65	25	,	,	PUNCT
clinmedi-179	65	26	there	there	PRON
clinmedi-179	65	27	was	be	VERB
clinmedi-179	65	28	only	only	ADV
clinmedi-179	65	29	one	one	NUM
clinmedi-179	65	30	secondary	secondary	ADJ
clinmedi-179	65	31	malignancy	malignancy	NOUN
clinmedi-179	65	32	in	in	ADP
clinmedi-179	65	33	a	a	DET
clinmedi-179	65	34	patient	patient	NOUN
clinmedi-179	65	35	who	who	PRON
clinmedi-179	65	36	developed	develop	VERB
clinmedi-179	65	37	acute	acute	ADJ
clinmedi-179	65	38	myeloid	myeloid	NOUN
clinmedi-179	65	39	leukemia	leukemia	NOUN
clinmedi-179	65	40	at	at	ADP
clinmedi-179	65	41	30	30	NUM
clinmedi-179	65	42	months	month	NOUN
clinmedi-179	65	43	after	after	ADP
clinmedi-179	65	44	enrollment	enrollment	NOUN
clinmedi-179	65	45	.	.	PUNCT
clinmedi-179	66	1	the	the	DET
clinmedi-179	66	2	patient	patient	NOUN
clinmedi-179	66	3	was	be	AUX
clinmedi-179	66	4	treated	treat	VERB
clinmedi-179	66	5	with	with	ADP
clinmedi-179	66	6	chemotherapy	chemotherapy	NOUN
clinmedi-179	66	7	and	and	CCONJ
clinmedi-179	66	8	hematopoietic	hematopoietic	ADJ
clinmedi-179	66	9	stem	stem	NOUN
clinmedi-179	66	10	cell	cell	NOUN
clinmedi-179	66	11	transplantation	transplantation	NOUN
clinmedi-179	66	12	and	and	CCONJ
clinmedi-179	66	13	was	be	AUX
clinmedi-179	66	14	disease	disease	NOUN
clinmedi-179	66	15	-	-	PUNCT
clinmedi-179	66	16	free	free	ADJ
clinmedi-179	66	17	with	with	ADP
clinmedi-179	66	18	pcr	pcr	NOUN
clinmedi-179	66	19	at	at	ADP
clinmedi-179	66	20	60	60	NUM
clinmedi-179	66	21	months	month	NOUN
clinmedi-179	66	22	of	of	ADP
clinmedi-179	66	23	follow	follow	NOUN
clinmedi-179	66	24	-	-	PUNCT
clinmedi-179	66	25	up	up	NOUN
clinmedi-179	66	26	.	.	PUNCT
clinmedi-179	67	1	there	there	PRON
clinmedi-179	67	2	were	be	VERB
clinmedi-179	67	3	two	two	NUM
clinmedi-179	67	4	locoregional	locoregional	ADJ
clinmedi-179	67	5	recurrences	recurrence	NOUN
clinmedi-179	67	6	at	at	ADP
clinmedi-179	67	7	a	a	DET
clinmedi-179	67	8	median	median	ADJ
clinmedi-179	67	9	follow	follow	NOUN
clinmedi-179	67	10	-	-	PUNCT
clinmedi-179	67	11	up	up	NOUN
clinmedi-179	67	12	of	of	ADP
clinmedi-179	67	13	61.5	61.5	NUM
clinmedi-179	67	14	months	month	NOUN
clinmedi-179	67	15	,	,	PUNCT
clinmedi-179	67	16	one	one	NUM
clinmedi-179	67	17	secondary	secondary	ADJ
clinmedi-179	67	18	malignancy	malignancy	NOUN
clinmedi-179	67	19	,	,	PUNCT
clinmedi-179	67	20	no	no	DET
clinmedi-179	67	21	systemic	systemic	ADJ
clinmedi-179	67	22	recurrence	recurrence	NOUN
clinmedi-179	67	23	,	,	PUNCT
clinmedi-179	67	24	and	and	CCONJ
clinmedi-179	67	25	no	no	DET
clinmedi-179	67	26	death	death	NOUN
clinmedi-179	67	27	from	from	ADP
clinmedi-179	67	28	any	any	DET
clinmedi-179	67	29	disease	disease	NOUN
clinmedi-179	67	30	.	.	PUNCT
clinmedi-179	68	1	therefore	therefore	ADV
clinmedi-179	68	2	,	,	PUNCT
clinmedi-179	68	3	at	at	ADP
clinmedi-179	68	4	the	the	DET
clinmedi-179	68	5	61.6	61.6	NUM
clinmedi-179	68	6	-	-	PUNCT
clinmedi-179	68	7	month	month	NOUN
clinmedi-179	68	8	follow	follow	NOUN
clinmedi-179	68	9	-	-	PUNCT
clinmedi-179	68	10	up	up	ADP
clinmedi-179	68	11	point	point	NOUN
clinmedi-179	68	12	,	,	PUNCT
clinmedi-179	68	13	rfs	rfs	PROPN
clinmedi-179	68	14	,	,	PUNCT
clinmedi-179	68	15	dfs	dfs	NOUN
clinmedi-179	68	16	,	,	PUNCT
clinmedi-179	68	17	and	and	CCONJ
clinmedi-179	68	18	os	os	NOUN
clinmedi-179	68	19	were	be	AUX
clinmedi-179	68	20	90	90	NUM
clinmedi-179	68	21	%	%	NOUN
clinmedi-179	68	22	,	,	PUNCT
clinmedi-179	68	23	85	85	NUM
clinmedi-179	68	24	%	%	NOUN
clinmedi-179	68	25	,	,	PUNCT
clinmedi-179	68	26	and	and	CCONJ
clinmedi-179	68	27	100	100	NUM
clinmedi-179	68	28	%	%	NOUN
clinmedi-179	68	29	,	,	PUNCT
clinmedi-179	68	30	respectively	respectively	ADV
clinmedi-179	68	31	.	.	PUNCT
clinmedi-179	69	1	achieving	achieve	VERB
clinmedi-179	69	2	the	the	DET
clinmedi-179	69	3	pcr	pcr	ADJ
clinmedi-179	69	4	or	or	CCONJ
clinmedi-179	69	5	hr	hr	NOUN
clinmedi-179	69	6	status	status	NOUN
clinmedi-179	69	7	did	do	AUX
clinmedi-179	69	8	not	not	PART
clinmedi-179	69	9	affect	affect	VERB
clinmedi-179	69	10	the	the	DET
clinmedi-179	69	11	rfs	rfs	NOUN
clinmedi-179	69	12	of	of	ADP
clinmedi-179	69	13	dfs	dfs	PROPN
clinmedi-179	69	14	.	.	PUNCT
clinmedi-179	69	15	toxicity	toxicity	NOUN
clinmedi-179	69	16	overall	overall	NOUN
clinmedi-179	69	17	,	,	PUNCT
clinmedi-179	69	18	95.0	95.0	NUM
clinmedi-179	69	19	%	%	NOUN
clinmedi-179	69	20	(	(	PUNCT
clinmedi-179	69	21	19/20	19/20	NUM
clinmedi-179	69	22	)	)	PUNCT
clinmedi-179	69	23	of	of	ADP
clinmedi-179	69	24	patients	patient	NOUN
clinmedi-179	69	25	experienced	experience	VERB
clinmedi-179	69	26	at	at	ADV
clinmedi-179	69	27	least	least	ADV
clinmedi-179	69	28	one	one	NUM
clinmedi-179	69	29	adverse	adverse	ADJ
clinmedi-179	69	30	effect	effect	NOUN
clinmedi-179	69	31	.	.	PUNCT
clinmedi-179	70	1	the	the	DET
clinmedi-179	70	2	toxicity	toxicity	NOUN
clinmedi-179	70	3	profiles	profile	NOUN
clinmedi-179	70	4	are	be	AUX
clinmedi-179	70	5	listed	list	VERB
clinmedi-179	70	6	in	in	ADP
clinmedi-179	70	7	table	table	NOUN
clinmedi-179	70	8	4	4	NUM
clinmedi-179	70	9	.	.	PUNCT
clinmedi-179	71	1	cpt	cpt	PROPN
clinmedi-179	71	2	n	n	CCONJ
clinmedi-179	71	3	(	(	PUNCT
clinmedi-179	71	4	%	%	INTJ
clinmedi-179	71	5	)	)	PUNCT
clinmedi-179	71	6	itt	itt	INTJ
clinmedi-179	71	7	n	n	PROPN
clinmedi-179	71	8	(	(	PUNCT
clinmedi-179	71	9	%	%	INTJ
clinmedi-179	71	10	)	)	PUNCT
clinmedi-179	71	11	total	total	ADJ
clinmedi-179	71	12	number	number	NOUN
clinmedi-179	71	13	of	of	ADP
clinmedi-179	71	14	patients	patient	NOUN
clinmedi-179	71	15	15	15	NUM
clinmedi-179	71	16	(	(	PUNCT
clinmedi-179	71	17	100.0	100.0	NUM
clinmedi-179	71	18	)	)	PUNCT
clinmedi-179	71	19	20	20	NUM
clinmedi-179	71	20	(	(	PUNCT
clinmedi-179	71	21	100.0	100.0	NUM
clinmedi-179	71	22	)	)	PUNCT
clinmedi-179	71	23	procedure	procedure	NOUN
clinmedi-179	71	24	(	(	PUNCT
clinmedi-179	71	25	breast	breast	NOUN
clinmedi-179	71	26	)	)	PUNCT
clinmedi-179	71	27	bp	bp	PROPN
clinmedi-179	71	28	bt	bt	PROPN
clinmedi-179	71	29	9	9	NUM
clinmedi-179	71	30	(	(	PUNCT
clinmedi-179	71	31	65.0	65.0	NUM
clinmedi-179	71	32	)	)	PUNCT
clinmedi-179	71	33	6	6	NUM
clinmedi-179	71	34	(	(	PUNCT
clinmedi-179	71	35	35.0	35.0	NUM
clinmedi-179	71	36	)	)	PUNCT
clinmedi-179	71	37	13	13	NUM
clinmedi-179	71	38	(	(	PUNCT
clinmedi-179	71	39	65.0	65.0	NUM
clinmedi-179	71	40	)	)	PUNCT
clinmedi-179	71	41	7	7	NUM
clinmedi-179	71	42	(	(	PUNCT
clinmedi-179	71	43	35.0	35.0	NUM
clinmedi-179	71	44	)	)	PUNCT
clinmedi-179	71	45	procedure	procedure	NOUN
clinmedi-179	71	46	(	(	PUNCT
clinmedi-179	71	47	lymph	lymph	NOUN
clinmedi-179	71	48	node	node	PROPN
clinmedi-179	71	49	)	)	PUNCT
clinmedi-179	71	50	sn	sn	NOUN
clinmedi-179	71	51	ax	ax	NOUN
clinmedi-179	71	52	9	9	NUM
clinmedi-179	71	53	(	(	PUNCT
clinmedi-179	71	54	60.0	60.0	NUM
clinmedi-179	71	55	)	)	PUNCT
clinmedi-179	71	56	6	6	NUM
clinmedi-179	71	57	(	(	PUNCT
clinmedi-179	71	58	40.0	40.0	NUM
clinmedi-179	71	59	)	)	PUNCT
clinmedi-179	71	60	12	12	NUM
clinmedi-179	71	61	(	(	PUNCT
clinmedi-179	71	62	60.0	60.0	NUM
clinmedi-179	71	63	)	)	SYM
clinmedi-179	71	64	8	8	NUM
clinmedi-179	71	65	(	(	PUNCT
clinmedi-179	71	66	40.0	40.0	NUM
clinmedi-179	71	67	)	)	PUNCT
clinmedi-179	71	68	pathological	pathological	ADJ
clinmedi-179	71	69	response	response	NOUN
clinmedi-179	71	70	ypt0ypn0	ypt0ypn0	PROPN
clinmedi-179	71	71	yptisypn0	yptisypn0	PROPN
clinmedi-179	71	72	other	other	ADJ
clinmedi-179	71	73	5	5	NUM
clinmedi-179	71	74	(	(	PUNCT
clinmedi-179	71	75	33.3	33.3	NUM
clinmedi-179	71	76	)	)	PUNCT
clinmedi-179	71	77	4	4	NUM
clinmedi-179	71	78	(	(	PUNCT
clinmedi-179	71	79	26.7	26.7	NUM
clinmedi-179	71	80	)	)	PUNCT
clinmedi-179	71	81	6	6	NUM
clinmedi-179	71	82	(	(	PUNCT
clinmedi-179	71	83	40.0	40.0	NUM
clinmedi-179	71	84	)	)	PUNCT
clinmedi-179	71	85	6	6	NUM
clinmedi-179	71	86	(	(	PUNCT
clinmedi-179	71	87	30.0	30.0	NUM
clinmedi-179	71	88	)	)	SYM
clinmedi-179	71	89	5	5	NUM
clinmedi-179	71	90	(	(	PUNCT
clinmedi-179	71	91	25.0	25.0	NUM
clinmedi-179	71	92	)	)	PUNCT
clinmedi-179	71	93	9	9	NUM
clinmedi-179	71	94	(	(	PUNCT
clinmedi-179	71	95	45.0	45.0	NUM
clinmedi-179	71	96	)	)	PUNCT
clinmedi-179	71	97	pathological	pathological	ADJ
clinmedi-179	71	98	response	response	NOUN
clinmedi-179	71	99	among	among	ADP
clinmedi-179	71	100	n1	n1	ADJ
clinmedi-179	71	101	patients	patient	NOUN
clinmedi-179	71	102	ypn+	ypn+	ADP
clinmedi-179	71	103	ypn0	ypn0	NOUN
clinmedi-179	71	104	2	2	NUM
clinmedi-179	71	105	(	(	PUNCT
clinmedi-179	71	106	22.2	22.2	NUM
clinmedi-179	71	107	)	)	PUNCT
clinmedi-179	71	108	7	7	NUM
clinmedi-179	71	109	(	(	PUNCT
clinmedi-179	71	110	77.8	77.8	NUM
clinmedi-179	71	111	)	)	PUNCT
clinmedi-179	71	112	3	3	NUM
clinmedi-179	71	113	(	(	PUNCT
clinmedi-179	71	114	25.0	25.0	NUM
clinmedi-179	71	115	)	)	PUNCT
clinmedi-179	71	116	9	9	NUM
clinmedi-179	71	117	(	(	PUNCT
clinmedi-179	71	118	75.0	75.0	NUM
clinmedi-179	71	119	)	)	PUNCT
clinmedi-179	71	120	subtype	subtype	NOUN
clinmedi-179	71	121	ypt+	ypt+	NOUN
clinmedi-179	71	122	or	or	CCONJ
clinmedi-179	71	123	n+	n+	PUNCT
clinmedi-179	71	124	yptisn0	yptisn0	PROPN
clinmedi-179	72	1	ypt0n0	ypt0n0	NOUN
clinmedi-179	72	2	%	%	PROPN
clinmedi-179	72	3	pcr	pcr	PROPN
clinmedi-179	72	4	p	p	PROPN
clinmedi-179	72	5	hr	hr	NOUN
clinmedi-179	72	6	+	+	CCONJ
clinmedi-179	72	7	hr	hr	NOUN
clinmedi-179	72	8	–	–	PUNCT
clinmedi-179	72	9	5	5	NUM
clinmedi-179	72	10	1	1	NUM
clinmedi-179	72	11	1	1	NUM
clinmedi-179	72	12	3	3	NUM
clinmedi-179	72	13	2	2	NUM
clinmedi-179	72	14	3	3	NUM
clinmedi-179	72	15	37.5	37.5	NUM
clinmedi-179	72	16	85.7	85.7	NUM
clinmedi-179	72	17	0.06	0.06	NUM
clinmedi-179	72	18	cmi	cmi	NOUN
clinmedi-179	72	19	04	04	NUM
clinmedi-179	72	20	(	(	PUNCT
clinmedi-179	72	21	02	02	NUM
clinmedi-179	72	22	)	)	PUNCT
clinmedi-179	72	23	,	,	PUNCT
clinmedi-179	72	24	378−386	378−386	NUM
clinmedi-179	72	25	cmi	cmi	PROPN
clinmedi-179	72	26	journal	journal	NOUN
clinmedi-179	72	27	383	383	NUM
clinmedi-179	72	28	cmi	cmi	PROPN
clinmedi-179	72	29	journal	journal	PROPN
clinmedi-179	72	30	kazumi	kazumi	PROPN
clinmedi-179	72	31	kawase	kawase	PROPN
clinmedi-179	72	32	et	et	PROPN
clinmedi-179	72	33	al	al	PROPN
clinmedi-179	72	34	.	.	PROPN
clinmedi-179	72	35	table	table	NOUN
clinmedi-179	72	36	4	4	NUM
clinmedi-179	72	37	.	.	PUNCT
clinmedi-179	72	38	toxicity	toxicity	NOUN
clinmedi-179	72	39	adverse	adverse	ADJ
clinmedi-179	72	40	event	event	NOUN
clinmedi-179	72	41	all	all	DET
clinmedi-179	72	42	grades	grade	NOUN
clinmedi-179	72	43	,	,	PUNCT
clinmedi-179	72	44	n	n	CCONJ
clinmedi-179	72	45	(	(	PUNCT
clinmedi-179	72	46	%	%	INTJ
clinmedi-179	72	47	)	)	PUNCT
clinmedi-179	72	48	grade	grade	NOUN
clinmedi-179	72	49	3,n	3,n	PROPN
clinmedi-179	72	50	(	(	PUNCT
clinmedi-179	72	51	%	%	NOUN
clinmedi-179	72	52	)	)	PUNCT
clinmedi-179	72	53	arthralgia	arthralgia	PROPN
clinmedi-179	72	54	/	/	SYM
clinmedi-179	72	55	myalgia	myalgia	PROPN
clinmedi-179	72	56	13	13	NUM
clinmedi-179	72	57	(	(	PUNCT
clinmedi-179	72	58	65.0	65.0	NUM
clinmedi-179	72	59	)	)	PUNCT
clinmedi-179	72	60	peripheral	peripheral	ADJ
clinmedi-179	72	61	neuropathy	neuropathy	ADJ
clinmedi-179	72	62	11	11	NUM
clinmedi-179	72	63	(	(	PUNCT
clinmedi-179	72	64	55.0	55.0	NUM
clinmedi-179	72	65	)	)	SYM
clinmedi-179	72	66	1	1	NUM
clinmedi-179	72	67	(	(	PUNCT
clinmedi-179	72	68	5.0	5.0	NUM
clinmedi-179	72	69	)	)	PUNCT
clinmedi-179	72	70	constipation	constipation	NOUN
clinmedi-179	72	71	6	6	NUM
clinmedi-179	72	72	(	(	PUNCT
clinmedi-179	72	73	30.0	30.0	NUM
clinmedi-179	72	74	)	)	PUNCT
clinmedi-179	72	75	fatigue	fatigue	NOUN
clinmedi-179	72	76	5	5	NUM
clinmedi-179	72	77	(	(	PUNCT
clinmedi-179	72	78	25.0	25.0	NUM
clinmedi-179	72	79	)	)	PUNCT
clinmedi-179	72	80	nausea	nausea	NOUN
clinmedi-179	72	81	/	/	SYM
clinmedi-179	72	82	vomiting	vomiting	NOUN
clinmedi-179	72	83	4	4	NUM
clinmedi-179	72	84	(	(	PUNCT
clinmedi-179	72	85	20.0	20.0	NUM
clinmedi-179	72	86	)	)	PUNCT
clinmedi-179	72	87	mucositis	mucositis	NOUN
clinmedi-179	72	88	4	4	NUM
clinmedi-179	72	89	(	(	PUNCT
clinmedi-179	72	90	20.0	20.0	NUM
clinmedi-179	72	91	)	)	PUNCT
clinmedi-179	72	92	skin	skin	NOUN
clinmedi-179	72	93	rash	rash	NOUN
clinmedi-179	72	94	3	3	NUM
clinmedi-179	72	95	(	(	PUNCT
clinmedi-179	72	96	15.0	15.0	NUM
clinmedi-179	72	97	)	)	PUNCT
clinmedi-179	72	98	neutropenic	neutropenic	ADJ
clinmedi-179	72	99	fever	fever	NOUN
clinmedi-179	72	100	2	2	NUM
clinmedi-179	72	101	(	(	PUNCT
clinmedi-179	72	102	10.0	10.0	NUM
clinmedi-179	72	103	)	)	SYM
clinmedi-179	72	104	2	2	NUM
clinmedi-179	72	105	(	(	PUNCT
clinmedi-179	72	106	10.0	10.0	NUM
clinmedi-179	72	107	)	)	PUNCT
clinmedi-179	72	108	anorexia	anorexia	NOUN
clinmedi-179	72	109	2	2	NUM
clinmedi-179	72	110	(	(	PUNCT
clinmedi-179	72	111	10.0	10.0	NUM
clinmedi-179	72	112	)	)	PUNCT
clinmedi-179	72	113	dose	dose	NOUN
clinmedi-179	72	114	reduction	reduction	NOUN
clinmedi-179	72	115	4	4	NUM
clinmedi-179	72	116	(	(	PUNCT
clinmedi-179	72	117	20.0	20.0	NUM
clinmedi-179	72	118	)	)	PUNCT
clinmedi-179	72	119	treatment	treatment	NOUN
clinmedi-179	72	120	postponement	postponement	NOUN
clinmedi-179	72	121	5	5	NUM
clinmedi-179	72	122	(	(	PUNCT
clinmedi-179	72	123	25.0	25.0	NUM
clinmedi-179	72	124	)	)	PUNCT
clinmedi-179	72	125	treatment	treatment	NOUN
clinmedi-179	72	126	discontinuation	discontinuation	NOUN
clinmedi-179	72	127	4	4	NUM
clinmedi-179	72	128	(	(	PUNCT
clinmedi-179	72	129	20.0	20.0	NUM
clinmedi-179	72	130	)	)	PUNCT
clinmedi-179	72	131	the	the	DET
clinmedi-179	72	132	most	most	ADV
clinmedi-179	72	133	frequent	frequent	ADJ
clinmedi-179	72	134	adverse	adverse	ADJ
clinmedi-179	72	135	event	event	NOUN
clinmedi-179	72	136	was	be	AUX
clinmedi-179	72	137	peripheral	peripheral	ADJ
clinmedi-179	72	138	sensory	sensory	ADJ
clinmedi-179	72	139	neuropathy	neuropathy	ADJ
clinmedi-179	72	140	(	(	PUNCT
clinmedi-179	72	141	psn	psn	NOUN
clinmedi-179	72	142	)	)	PUNCT
clinmedi-179	72	143	(	(	PUNCT
clinmedi-179	72	144	11/20	11/20	NUM
clinmedi-179	72	145	,	,	PUNCT
clinmedi-179	72	146	55.0	55.0	NUM
clinmedi-179	72	147	%	%	NOUN
clinmedi-179	72	148	)	)	PUNCT
clinmedi-179	72	149	,	,	PUNCT
clinmedi-179	72	150	including	include	VERB
clinmedi-179	72	151	grade-3	grade-3	NUM
clinmedi-179	72	152	neuropathy	neuropathy	ADJ
clinmedi-179	72	153	in	in	ADP
clinmedi-179	72	154	one	one	NUM
clinmedi-179	72	155	patient	patient	NOUN
clinmedi-179	72	156	(	(	PUNCT
clinmedi-179	72	157	5.0	5.0	NUM
clinmedi-179	72	158	%	%	NOUN
clinmedi-179	72	159	)	)	PUNCT
clinmedi-179	72	160	.	.	PUNCT
clinmedi-179	73	1	among	among	ADP
clinmedi-179	73	2	patients	patient	NOUN
clinmedi-179	73	3	who	who	PRON
clinmedi-179	73	4	experienced	experience	VERB
clinmedi-179	73	5	psn	psn	PROPN
clinmedi-179	73	6	,	,	PUNCT
clinmedi-179	73	7	18.2	18.2	NUM
clinmedi-179	73	8	%	%	NOUN
clinmedi-179	73	9	(	(	PUNCT
clinmedi-179	73	10	2/11	2/11	NUM
clinmedi-179	73	11	)	)	PUNCT
clinmedi-179	73	12	complained	complain	VERB
clinmedi-179	73	13	of	of	ADP
clinmedi-179	73	14	numbness	numbness	NOUN
clinmedi-179	73	15	and/or	and/or	CCONJ
clinmedi-179	73	16	paresthesia	paresthesia	NOUN
clinmedi-179	73	17	in	in	ADP
clinmedi-179	73	18	the	the	DET
clinmedi-179	73	19	foot	foot	NOUN
clinmedi-179	73	20	following	follow	VERB
clinmedi-179	73	21	a	a	DET
clinmedi-179	73	22	median	median	ADJ
clinmedi-179	73	23	time	time	NOUN
clinmedi-179	73	24	of	of	ADP
clinmedi-179	73	25	61.5	61.5	NUM
clinmedi-179	73	26	(	(	PUNCT
clinmedi-179	73	27	37–86	37–86	NUM
clinmedi-179	73	28	)	)	PUNCT
clinmedi-179	73	29	months	month	NOUN
clinmedi-179	73	30	of	of	ADP
clinmedi-179	73	31	follow	follow	NOUN
clinmedi-179	73	32	-	-	PUNCT
clinmedi-179	73	33	up	up	NOUN
clinmedi-179	73	34	.	.	PUNCT
clinmedi-179	74	1	two	two	NUM
clinmedi-179	74	2	patients	patient	NOUN
clinmedi-179	74	3	had	have	VERB
clinmedi-179	74	4	grade	grade	NOUN
clinmedi-179	74	5	3	3	NUM
clinmedi-179	74	6	neutropenic	neutropenic	ADJ
clinmedi-179	74	7	fever	fever	NOUN
clinmedi-179	74	8	during	during	ADP
clinmedi-179	74	9	the	the	DET
clinmedi-179	74	10	fec	fec	PROPN
clinmedi-179	74	11	treatment	treatment	PROPN
clinmedi-179	74	12	.	.	PUNCT
clinmedi-179	75	1	discussion	discussion	NOUN
clinmedi-179	75	2	the	the	DET
clinmedi-179	75	3	aim	aim	NOUN
clinmedi-179	75	4	of	of	ADP
clinmedi-179	75	5	this	this	DET
clinmedi-179	75	6	study	study	NOUN
clinmedi-179	75	7	was	be	AUX
clinmedi-179	75	8	to	to	PART
clinmedi-179	75	9	examine	examine	VERB
clinmedi-179	75	10	the	the	DET
clinmedi-179	75	11	effects	effect	NOUN
clinmedi-179	75	12	of	of	ADP
clinmedi-179	75	13	q3w	q3w	NOUN
clinmedi-179	75	14	low	low	ADV
clinmedi-179	75	15	-	-	PUNCT
clinmedi-179	75	16	dose	dose	NOUN
clinmedi-179	75	17	nab	nab	NOUN
clinmedi-179	75	18	-	-	PUNCT
clinmedi-179	75	19	ptx	ptx	NOUN
clinmedi-179	75	20	(	(	PUNCT
clinmedi-179	75	21	220	220	NUM
clinmedi-179	75	22	mg	mg	NUM
clinmedi-179	75	23	/	/	SYM
clinmedi-179	75	24	m	m	VERB
clinmedi-179	75	25	2	2	NUM
clinmedi-179	75	26	)	)	PUNCT
clinmedi-179	75	27	followed	follow	VERB
clinmedi-179	75	28	by	by	ADP
clinmedi-179	75	29	fec75	fec75	PROPN
clinmedi-179	75	30	(	(	PUNCT
clinmedi-179	75	31	5	5	NUM
clinmedi-179	75	32	-	-	PUNCT
clinmedi-179	75	33	fluorouracil	fluorouracil	NOUN
clinmedi-179	75	34	:	:	PUNCT
clinmedi-179	75	35	500	500	NUM
clinmedi-179	75	36	mg	mg	NUM
clinmedi-179	75	37	/	/	SYM
clinmedi-179	75	38	m	m	PROPN
clinmedi-179	75	39	2	2	NUM
clinmedi-179	75	40	,	,	PUNCT
clinmedi-179	75	41	epirubicin	epirubicin	PRON
clinmedi-179	75	42	:	:	PUNCT
clinmedi-179	75	43	75	75	NUM
clinmedi-179	75	44	mg	mg	NUM
clinmedi-179	75	45	/	/	SYM
clinmedi-179	75	46	m	m	PROPN
clinmedi-179	75	47	2	2	NUM
clinmedi-179	75	48	,	,	PUNCT
clinmedi-179	75	49	and	and	CCONJ
clinmedi-179	75	50	cyclophosphamide	cyclophosphamide	NOUN
clinmedi-179	75	51	:	:	PUNCT
clinmedi-179	75	52	500	500	NUM
clinmedi-179	75	53	mg	mg	NUM
clinmedi-179	75	54	/	/	SYM
clinmedi-179	75	55	m	m	VERB
clinmedi-179	75	56	2	2	NUM
clinmedi-179	75	57	)	)	PUNCT
clinmedi-179	75	58	as	as	ADP
clinmedi-179	75	59	a	a	DET
clinmedi-179	75	60	neoadjuvant	neoadjuvant	ADJ
clinmedi-179	75	61	treatment	treatment	NOUN
clinmedi-179	75	62	for	for	ADP
clinmedi-179	75	63	her2	her2	PROPN
clinmedi-179	75	64	+	+	CCONJ
clinmedi-179	75	65	breast	breast	NOUN
clinmedi-179	75	66	cancer	cancer	NOUN
clinmedi-179	75	67	.	.	PUNCT
clinmedi-179	76	1	the	the	DET
clinmedi-179	76	2	results	result	NOUN
clinmedi-179	76	3	revealed	reveal	VERB
clinmedi-179	76	4	an	an	DET
clinmedi-179	76	5	overall	overall	ADJ
clinmedi-179	76	6	pcr	pcr	ADJ
clinmedi-179	76	7	rate	rate	NOUN
clinmedi-179	76	8	of	of	ADP
clinmedi-179	76	9	60.0	60.0	NUM
clinmedi-179	76	10	%	%	NOUN
clinmedi-179	76	11	and	and	CCONJ
clinmedi-179	76	12	excellent	excellent	ADJ
clinmedi-179	76	13	3	3	NUM
clinmedi-179	76	14	-	-	PUNCT
clinmedi-179	76	15	year	year	NOUN
clinmedi-179	76	16	rfs	rfs	NOUN
clinmedi-179	76	17	and	and	CCONJ
clinmedi-179	76	18	dfs	dfs	PROPN
clinmedi-179	76	19	.	.	PUNCT
clinmedi-179	77	1	various	various	ADJ
clinmedi-179	77	2	studies	study	NOUN
clinmedi-179	77	3	have	have	AUX
clinmedi-179	77	4	demonstrated	demonstrate	VERB
clinmedi-179	77	5	the	the	DET
clinmedi-179	77	6	efficacy	efficacy	NOUN
clinmedi-179	77	7	of	of	ADP
clinmedi-179	77	8	nab	nab	NOUN
clinmedi-179	77	9	-	-	PUNCT
clinmedi-179	77	10	ptx	ptx	NOUN
clinmedi-179	77	11	in	in	ADP
clinmedi-179	77	12	metastatic	metastatic	ADJ
clinmedi-179	77	13	or	or	CCONJ
clinmedi-179	77	14	advanced	advanced	ADJ
clinmedi-179	77	15	breast	breast	NOUN
clinmedi-179	77	16	cancer	cancer	NOUN
clinmedi-179	77	17	.	.	PUNCT
clinmedi-179	78	1	5–8	5–8	NOUN
clinmedi-179	78	2	in	in	ADP
clinmedi-179	78	3	the	the	DET
clinmedi-179	78	4	metastatic	metastatic	ADJ
clinmedi-179	78	5	setting	setting	NOUN
clinmedi-179	78	6	,	,	PUNCT
clinmedi-179	78	7	q3w	q3w	NOUN
clinmedi-179	78	8	nab	nab	NOUN
clinmedi-179	78	9	-	-	PUNCT
clinmedi-179	78	10	ptx	ptx	NOUN
clinmedi-179	78	11	(	(	PUNCT
clinmedi-179	78	12	260	260	NUM
clinmedi-179	78	13	mg	mg	NUM
clinmedi-179	78	14	/	/	SYM
clinmedi-179	78	15	m	m	VERB
clinmedi-179	78	16	2	2	NUM
clinmedi-179	78	17	)	)	PUNCT
clinmedi-179	78	18	showed	show	VERB
clinmedi-179	78	19	a	a	DET
clinmedi-179	78	20	superior	superior	ADJ
clinmedi-179	78	21	response	response	NOUN
clinmedi-179	78	22	than	than	ADP
clinmedi-179	78	23	sbptx	sbptx	VERB
clinmedi-179	78	24	175	175	NUM
clinmedi-179	78	25	mg	mg	PROPN
clinmedi-179	78	26	/	/	SYM
clinmedi-179	78	27	m	m	PROPN
clinmedi-179	78	28	2	2	NUM
clinmedi-179	78	29	.	.	PUNCT
clinmedi-179	78	30	7	7	NUM
clinmedi-179	78	31	in	in	ADP
clinmedi-179	78	32	addition	addition	NOUN
clinmedi-179	78	33	,	,	PUNCT
clinmedi-179	78	34	a	a	DET
clinmedi-179	78	35	randomized	randomized	ADJ
clinmedi-179	78	36	phase	phase	NOUN
clinmedi-179	78	37	ii	ii	NOUN
clinmedi-179	78	38	study	study	NOUN
clinmedi-179	78	39	in	in	ADP
clinmedi-179	78	40	which	which	PRON
clinmedi-179	78	41	patients	patient	NOUN
clinmedi-179	78	42	with	with	ADP
clinmedi-179	78	43	previously	previously	ADV
clinmedi-179	78	44	untreated	untreated	ADJ
clinmedi-179	78	45	metastatic	metastatic	ADJ
clinmedi-179	78	46	breast	breast	NOUN
clinmedi-179	78	47	cancer	cancer	NOUN
clinmedi-179	78	48	were	be	AUX
clinmedi-179	78	49	administered	administer	VERB
clinmedi-179	78	50	nab	nab	ADJ
clinmedi-179	78	51	-	-	PUNCT
clinmedi-179	78	52	ptx	ptx	NOUN
clinmedi-179	78	53	300	300	NUM
clinmedi-179	78	54	mg	mg	PROPN
clinmedi-179	78	55	/	/	SYM
clinmedi-179	78	56	m	m	VERB
clinmedi-179	78	57	2	2	NUM
clinmedi-179	78	58	q3w	q3w	NOUN
clinmedi-179	78	59	,	,	PUNCT
clinmedi-179	78	60	100	100	NUM
clinmedi-179	78	61	mg	mg	NUM
clinmedi-179	78	62	/	/	SYM
clinmedi-179	78	63	m	m	PROPN
clinmedi-179	78	64	2	2	NUM
clinmedi-179	78	65	weekly	weekly	NOUN
clinmedi-179	78	66	,	,	PUNCT
clinmedi-179	78	67	150	150	NUM
clinmedi-179	78	68	mg	mg	NUM
clinmedi-179	78	69	/	/	SYM
clinmedi-179	78	70	m	m	PROPN
clinmedi-179	78	71	2	2	NUM
clinmedi-179	78	72	weekly	weekly	NOUN
clinmedi-179	78	73	,	,	PUNCT
clinmedi-179	78	74	or	or	CCONJ
clinmedi-179	78	75	docetaxel	docetaxel	VERB
clinmedi-179	78	76	100	100	NUM
clinmedi-179	78	77	mg	mg	PROPN
clinmedi-179	78	78	/	/	SYM
clinmedi-179	78	79	m	m	VERB
clinmedi-179	78	80	2	2	NUM
clinmedi-179	78	81	q3w	q3w	NOUN
clinmedi-179	78	82	,	,	PUNCT
clinmedi-179	78	83	weekly	weekly	ADJ
clinmedi-179	78	84	nab	nab	NOUN
clinmedi-179	78	85	-	-	PUNCT
clinmedi-179	78	86	ptx	ptx	NOUN
clinmedi-179	78	87	at	at	ADP
clinmedi-179	78	88	150	150	NUM
clinmedi-179	78	89	mg	mg	NUM
clinmedi-179	78	90	/	/	SYM
clinmedi-179	78	91	m	m	VERB
clinmedi-179	78	92	2	2	NUM
clinmedi-179	78	93	demonstrated	demonstrate	VERB
clinmedi-179	78	94	superior	superior	ADJ
clinmedi-179	78	95	efficacy	efficacy	NOUN
clinmedi-179	78	96	and	and	CCONJ
clinmedi-179	78	97	safety	safety	NOUN
clinmedi-179	78	98	over	over	ADP
clinmedi-179	78	99	docetaxel	docetaxel	PROPN
clinmedi-179	78	100	.	.	PUNCT
clinmedi-179	79	1	10	10	NUM
clinmedi-179	79	2	subsequently	subsequently	ADV
clinmedi-179	79	3	,	,	PUNCT
clinmedi-179	79	4	the	the	DET
clinmedi-179	79	5	nab	nab	VERB
clinmedi-179	79	6	-	-	PUNCT
clinmedi-179	79	7	ptx	ptx	NOUN
clinmedi-179	79	8	dose	dose	NOUN
clinmedi-179	79	9	,	,	PUNCT
clinmedi-179	79	10	and	and	CCONJ
clinmedi-179	79	11	schedule	schedule	NOUN
clinmedi-179	79	12	in	in	ADP
clinmedi-179	79	13	neoadjuvant	neoadjuvant	ADJ
clinmedi-179	79	14	settings	setting	NOUN
clinmedi-179	79	15	have	have	AUX
clinmedi-179	79	16	been	be	AUX
clinmedi-179	79	17	evaluated	evaluate	VERB
clinmedi-179	79	18	in	in	ADP
clinmedi-179	79	19	several	several	ADJ
clinmedi-179	79	20	studies	study	NOUN
clinmedi-179	79	21	.	.	PUNCT
clinmedi-179	80	1	in	in	ADP
clinmedi-179	80	2	studies	study	NOUN
clinmedi-179	80	3	on	on	ADP
clinmedi-179	80	4	nabptx	nabptx	PROPN
clinmedi-179	80	5	combined	combine	VERB
clinmedi-179	80	6	with	with	ADP
clinmedi-179	80	7	anthracycline	anthracycline	NOUN
clinmedi-179	80	8	therapy	therapy	NOUN
clinmedi-179	80	9	,	,	PUNCT
clinmedi-179	80	10	the	the	DET
clinmedi-179	80	11	pcr	pcr	ADJ
clinmedi-179	80	12	rate	rate	NOUN
clinmedi-179	80	13	for	for	ADP
clinmedi-179	80	14	breast	breast	NOUN
clinmedi-179	80	15	cancer	cancer	NOUN
clinmedi-179	80	16	including	include	VERB
clinmedi-179	80	17	all	all	DET
clinmedi-179	80	18	subtypes	subtype	NOUN
clinmedi-179	80	19	(	(	PUNCT
clinmedi-179	80	20	hr	hr	NOUN
clinmedi-179	80	21	+	+	NOUN
clinmedi-179	80	22	/her2	/her2	PUNCT
clinmedi-179	81	1	+	+	CCONJ
clinmedi-179	81	2	,	,	PUNCT
clinmedi-179	81	3	hr	hr	NOUN
clinmedi-179	81	4	–	–	PUNCT
clinmedi-179	81	5	/her2	/her2	PUNCT
clinmedi-179	82	1	+	+	CCONJ
clinmedi-179	82	2	,	,	PUNCT
clinmedi-179	82	3	hr	hr	NOUN
clinmedi-179	82	4	+	+	CCONJ
clinmedi-179	82	5	her2	her2	PROPN
clinmedi-179	82	6	–	–	PUNCT
clinmedi-179	82	7	,	,	PUNCT
clinmedi-179	82	8	hr	hr	NOUN
clinmedi-179	82	9	+	+	CCONJ
clinmedi-179	82	10	her2	her2	PROPN
clinmedi-179	82	11	–	–	PUNCT
clinmedi-179	82	12	)	)	PUNCT
clinmedi-179	82	13	has	have	AUX
clinmedi-179	82	14	been	be	AUX
clinmedi-179	82	15	20%–40	20%–40	NUM
clinmedi-179	82	16	%	%	NOUN
clinmedi-179	82	17	.	.	PUNCT
clinmedi-179	83	1	11–15	11–15	NUM
clinmedi-179	83	2	in	in	ADP
clinmedi-179	83	3	most	most	ADJ
clinmedi-179	83	4	studies	study	NOUN
clinmedi-179	83	5	,	,	PUNCT
clinmedi-179	83	6	the	the	DET
clinmedi-179	83	7	dose	dose	NOUN
clinmedi-179	83	8	of	of	ADP
clinmedi-179	83	9	nab	nab	NOUN
clinmedi-179	83	10	-	-	PUNCT
clinmedi-179	83	11	ptx	ptx	NOUN
clinmedi-179	83	12	used	use	VERB
clinmedi-179	83	13	has	have	AUX
clinmedi-179	83	14	been	be	AUX
clinmedi-179	83	15	260	260	NUM
clinmedi-179	83	16	mg	mg	NUM
clinmedi-179	83	17	/	/	SYM
clinmedi-179	83	18	m	m	VERB
clinmedi-179	83	19	2	2	NUM
clinmedi-179	83	20	q3w	q3w	ADP
clinmedi-179	83	21	or	or	CCONJ
clinmedi-179	83	22	125	125	NUM
clinmedi-179	83	23	mg	mg	NUM
clinmedi-179	83	24	/	/	SYM
clinmedi-179	83	25	m	m	PROPN
clinmedi-179	83	26	2	2	NUM
clinmedi-179	83	27	weekly	weekly	NOUN
clinmedi-179	83	28	.	.	PUNCT
clinmedi-179	84	1	the	the	DET
clinmedi-179	84	2	pcr	pcr	PROPN
clinmedi-179	84	3	rates	rate	NOUN
clinmedi-179	84	4	varied	varied	ADJ
clinmedi-179	84	5	according	accord	VERB
clinmedi-179	84	6	to	to	ADP
clinmedi-179	84	7	the	the	DET
clinmedi-179	84	8	hr	hr	NOUN
clinmedi-179	84	9	and	and	CCONJ
clinmedi-179	84	10	her2	her2	PROPN
clinmedi-179	84	11	status	status	NOUN
clinmedi-179	84	12	,	,	PUNCT
clinmedi-179	84	13	with	with	ADP
clinmedi-179	84	14	a	a	DET
clinmedi-179	84	15	high	high	ADJ
clinmedi-179	84	16	pcr	pcr	NOUN
clinmedi-179	84	17	rate	rate	NOUN
clinmedi-179	84	18	(	(	PUNCT
clinmedi-179	84	19	60%–75	60%–75	NUM
clinmedi-179	84	20	%	%	NOUN
clinmedi-179	84	21	)	)	PUNCT
clinmedi-179	84	22	observed	observe	VERB
clinmedi-179	84	23	in	in	ADP
clinmedi-179	84	24	her2	her2	PROPN
clinmedi-179	84	25	+	+	CCONJ
clinmedi-179	84	26	patients	patient	NOUN
clinmedi-179	84	27	,	,	PUNCT
clinmedi-179	84	28	particularly	particularly	ADV
clinmedi-179	84	29	in	in	ADP
clinmedi-179	84	30	hr	hr	NOUN
clinmedi-179	84	31	–	–	PUNCT
clinmedi-179	84	32	/her2	/her2	PUNCT
clinmedi-179	85	1	+	+	NUM
clinmedi-179	85	2	patients	patient	NOUN
clinmedi-179	85	3	.	.	PUNCT
clinmedi-179	86	1	11,12,16	11,12,16	NUM
clinmedi-179	86	2	initially	initially	ADV
clinmedi-179	86	3	,	,	PUNCT
clinmedi-179	86	4	we	we	PRON
clinmedi-179	86	5	used	use	VERB
clinmedi-179	86	6	nab	nab	ADJ
clinmedi-179	86	7	-	-	PUNCT
clinmedi-179	86	8	ptx	ptx	NOUN
clinmedi-179	86	9	260mg	260mg	NOUN
clinmedi-179	86	10	/	/	SYM
clinmedi-179	86	11	m	m	PROPN
clinmedi-179	86	12	2	2	NUM
clinmedi-179	86	13	q3w	q3w	NOUN
clinmedi-179	86	14	,	,	PUNCT
clinmedi-179	86	15	however	however	ADV
clinmedi-179	86	16	,	,	PUNCT
clinmedi-179	86	17	as	as	SCONJ
clinmedi-179	86	18	many	many	ADJ
clinmedi-179	86	19	patients	patient	NOUN
clinmedi-179	86	20	were	be	AUX
clinmedi-179	86	21	required	require	VERB
clinmedi-179	86	22	nab	nab	ADJ
clinmedi-179	86	23	-	-	PUNCT
clinmedi-179	86	24	ptx	ptx	NOUN
clinmedi-179	86	25	dose	dose	NOUN
clinmedi-179	86	26	reduction	reduction	NOUN
clinmedi-179	86	27	to	to	ADP
clinmedi-179	86	28	220	220	NUM
clinmedi-179	86	29	mg	mg	NOUN
clinmedi-179	86	30	,	,	PUNCT
clinmedi-179	86	31	which	which	PRON
clinmedi-179	86	32	is	be	AUX
clinmedi-179	86	33	recommended	recommend	VERB
clinmedi-179	86	34	usage	usage	NOUN
clinmedi-179	86	35	as	as	ADP
clinmedi-179	86	36	one	one	NUM
clinmedi-179	86	37	step	step	NOUN
clinmedi-179	86	38	dose	dose	NOUN
clinmedi-179	86	39	reduction	reduction	NOUN
clinmedi-179	86	40	in	in	ADP
clinmedi-179	86	41	reference	reference	NOUN
clinmedi-179	86	42	to	to	ADP
clinmedi-179	86	43	the	the	DET
clinmedi-179	86	44	product	product	NOUN
clinmedi-179	86	45	document	document	NOUN
clinmedi-179	86	46	,	,	PUNCT
clinmedi-179	86	47	we	we	PRON
clinmedi-179	86	48	intended	intend	VERB
clinmedi-179	86	49	to	to	PART
clinmedi-179	86	50	proceed	proceed	VERB
clinmedi-179	86	51	this	this	DET
clinmedi-179	86	52	study	study	NOUN
clinmedi-179	86	53	.	.	PUNCT
clinmedi-179	87	1	we	we	PRON
clinmedi-179	87	2	found	find	VERB
clinmedi-179	87	3	a	a	DET
clinmedi-179	87	4	pcr	pcr	ADJ
clinmedi-179	87	5	rate	rate	NOUN
clinmedi-179	87	6	of	of	ADP
clinmedi-179	87	7	85.7	85.7	NUM
clinmedi-179	87	8	%	%	NOUN
clinmedi-179	87	9	in	in	ADP
clinmedi-179	87	10	hr	hr	NOUN
clinmedi-179	87	11	–	–	PUNCT
clinmedi-179	87	12	/her2	/her2	PUNCT
clinmedi-179	88	1	+	+	NUM
clinmedi-179	88	2	patients	patient	NOUN
clinmedi-179	88	3	,	,	PUNCT
clinmedi-179	88	4	which	which	PRON
clinmedi-179	88	5	is	be	AUX
clinmedi-179	88	6	comparable	comparable	ADJ
clinmedi-179	88	7	to	to	ADP
clinmedi-179	88	8	that	that	PRON
clinmedi-179	88	9	in	in	ADP
clinmedi-179	88	10	previous	previous	ADJ
clinmedi-179	88	11	studies	study	NOUN
clinmedi-179	88	12	,	,	PUNCT
clinmedi-179	88	13	although	although	SCONJ
clinmedi-179	88	14	we	we	PRON
clinmedi-179	88	15	used	use	VERB
clinmedi-179	88	16	a	a	DET
clinmedi-179	88	17	low	low	ADJ
clinmedi-179	88	18	dose	dose	NOUN
clinmedi-179	88	19	of	of	ADP
clinmedi-179	88	20	q3w	q3w	NOUN
clinmedi-179	88	21	nab	nab	NOUN
clinmedi-179	88	22	-	-	PUNCT
clinmedi-179	88	23	ptx	ptx	NOUN
clinmedi-179	88	24	(	(	PUNCT
clinmedi-179	88	25	220	220	NUM
clinmedi-179	88	26	mg	mg	NUM
clinmedi-179	88	27	/	/	SYM
clinmedi-179	88	28	m	m	VERB
clinmedi-179	88	29	2	2	NUM
clinmedi-179	88	30	)	)	PUNCT
clinmedi-179	88	31	and	and	CCONJ
clinmedi-179	88	32	fec75	fec75	PROPN
clinmedi-179	88	33	.	.	PUNCT
clinmedi-179	89	1	the	the	DET
clinmedi-179	89	2	geparsepto	geparsepto	PROPN
clinmedi-179	89	3	trial	trial	NOUN
clinmedi-179	89	4	was	be	AUX
clinmedi-179	89	5	performed	perform	VERB
clinmedi-179	89	6	to	to	PART
clinmedi-179	89	7	compare	compare	VERB
clinmedi-179	89	8	the	the	DET
clinmedi-179	89	9	effectiveness	effectiveness	NOUN
clinmedi-179	89	10	of	of	ADP
clinmedi-179	89	11	weekly	weekly	ADJ
clinmedi-179	89	12	nab	nab	NOUN
clinmedi-179	89	13	-	-	PUNCT
clinmedi-179	89	14	ptx	ptx	NOUN
clinmedi-179	89	15	150	150	NUM
clinmedi-179	89	16	mg	mg	NUM
clinmedi-179	89	17	/	/	SYM
clinmedi-179	89	18	m	m	VERB
clinmedi-179	89	19	2	2	NUM
clinmedi-179	89	20	(	(	PUNCT
clinmedi-179	89	21	reduced	reduce	VERB
clinmedi-179	89	22	to	to	ADP
clinmedi-179	89	23	125	125	NUM
clinmedi-179	89	24	mg	mg	PROPN
clinmedi-179	89	25	/	/	SYM
clinmedi-179	89	26	m	m	VERB
clinmedi-179	89	27	2	2	NUM
clinmedi-179	89	28	following	follow	VERB
clinmedi-179	89	29	study	study	NOUN
clinmedi-179	89	30	amendment	amendment	NOUN
clinmedi-179	89	31	)	)	PUNCT
clinmedi-179	89	32	with	with	ADP
clinmedi-179	89	33	weekly	weekly	ADJ
clinmedi-179	89	34	sb	sb	NOUN
clinmedi-179	89	35	-	-	ADJ
clinmedi-179	89	36	ptx	ptx	NOUN
clinmedi-179	89	37	80	80	NUM
clinmedi-179	89	38	mg	mg	PROPN
clinmedi-179	89	39	/	/	SYM
clinmedi-179	89	40	m	m	VERB
clinmedi-179	89	41	2	2	NUM
clinmedi-179	89	42	followed	follow	VERB
clinmedi-179	89	43	by	by	ADP
clinmedi-179	89	44	ec	ec	PROPN
clinmedi-179	89	45	demonstrated	demonstrate	VERB
clinmedi-179	89	46	that	that	SCONJ
clinmedi-179	89	47	patients	patient	NOUN
clinmedi-179	89	48	treated	treat	VERB
clinmedi-179	89	49	with	with	ADP
clinmedi-179	89	50	nab	nab	NOUN
clinmedi-179	89	51	-	-	PUNCT
clinmedi-179	89	52	ptx	ptx	NOUN
clinmedi-179	89	53	had	have	VERB
clinmedi-179	89	54	a	a	DET
clinmedi-179	89	55	significantly	significantly	ADV
clinmedi-179	89	56	better	well	ADJ
clinmedi-179	89	57	dfs	dfs	NOUN
clinmedi-179	89	58	than	than	SCONJ
clinmedi-179	89	59	patients	patient	NOUN
clinmedi-179	89	60	treated	treat	VERB
clinmedi-179	89	61	with	with	ADP
clinmedi-179	89	62	sb	sb	NOUN
clinmedi-179	89	63	-	-	PROPN
clinmedi-179	89	64	ptx	ptx	NOUN
clinmedi-179	89	65	.	.	PROPN
clinmedi-179	89	66	17	17	NUM
clinmedi-179	89	67	in	in	ADP
clinmedi-179	89	68	this	this	DET
clinmedi-179	89	69	trial	trial	NOUN
clinmedi-179	89	70	,	,	PUNCT
clinmedi-179	89	71	a	a	DET
clinmedi-179	89	72	significantly	significantly	ADV
clinmedi-179	89	73	higher	high	ADJ
clinmedi-179	89	74	pcr	pcr	ADJ
clinmedi-179	89	75	rate	rate	NOUN
clinmedi-179	89	76	was	be	AUX
clinmedi-179	89	77	associated	associate	VERB
clinmedi-179	89	78	with	with	ADP
clinmedi-179	89	79	a	a	DET
clinmedi-179	89	80	significantly	significantly	ADV
clinmedi-179	89	81	improved	improve	VERB
clinmedi-179	89	82	invasive	invasive	ADJ
clinmedi-179	89	83	dfs	dfs	NOUN
clinmedi-179	89	84	,	,	PUNCT
clinmedi-179	89	85	and	and	CCONJ
clinmedi-179	89	86	the	the	DET
clinmedi-179	89	87	estimated	estimate	VERB
clinmedi-179	89	88	36	36	NUM
clinmedi-179	89	89	-	-	PUNCT
clinmedi-179	89	90	month	month	NOUN
clinmedi-179	89	91	dfs	dfs	NOUN
clinmedi-179	89	92	was	be	AUX
clinmedi-179	89	93	91.8	91.8	NUM
clinmedi-179	89	94	%	%	NOUN
clinmedi-179	89	95	in	in	ADP
clinmedi-179	89	96	the	the	DET
clinmedi-179	89	97	hr	hr	NOUN
clinmedi-179	89	98	–	–	PUNCT
clinmedi-179	89	99	/her2	/her2	PUNCT
clinmedi-179	90	1	+	+	NUM
clinmedi-179	90	2	subgroup	subgroup	NOUN
clinmedi-179	90	3	.	.	PUNCT
clinmedi-179	91	1	we	we	PRON
clinmedi-179	91	2	observed	observe	VERB
clinmedi-179	91	3	comparable	comparable	ADJ
clinmedi-179	91	4	results	result	NOUN
clinmedi-179	91	5	with	with	ADP
clinmedi-179	91	6	36	36	NUM
clinmedi-179	91	7	-	-	PUNCT
clinmedi-179	91	8	month	month	NOUN
clinmedi-179	91	9	rfs	rf	NOUN
clinmedi-179	91	10	,	,	PUNCT
clinmedi-179	91	11	dfs	dfs	NOUN
clinmedi-179	91	12	,	,	PUNCT
clinmedi-179	91	13	and	and	CCONJ
clinmedi-179	91	14	os	os	NOUN
clinmedi-179	91	15	of	of	ADP
clinmedi-179	91	16	90	90	NUM
clinmedi-179	91	17	%	%	NOUN
clinmedi-179	91	18	,	,	PUNCT
clinmedi-179	91	19	85	85	NUM
clinmedi-179	91	20	%	%	NOUN
clinmedi-179	91	21	,	,	PUNCT
clinmedi-179	91	22	and	and	CCONJ
clinmedi-179	91	23	100	100	NUM
clinmedi-179	91	24	%	%	NOUN
clinmedi-179	91	25	,	,	PUNCT
clinmedi-179	91	26	respectively	respectively	ADV
clinmedi-179	91	27	.	.	PUNCT
clinmedi-179	92	1	there	there	PRON
clinmedi-179	92	2	was	be	VERB
clinmedi-179	92	3	no	no	DET
clinmedi-179	92	4	survival	survival	NOUN
clinmedi-179	92	5	difference	difference	NOUN
clinmedi-179	92	6	depending	depend	VERB
clinmedi-179	92	7	on	on	ADP
clinmedi-179	92	8	the	the	DET
clinmedi-179	92	9	hr	hr	NOUN
clinmedi-179	92	10	status	status	NOUN
clinmedi-179	92	11	or	or	CCONJ
clinmedi-179	92	12	pcr	pcr	ADJ
clinmedi-179	92	13	status	status	NOUN
clinmedi-179	92	14	,	,	PUNCT
clinmedi-179	92	15	possibly	possibly	ADV
clinmedi-179	92	16	because	because	SCONJ
clinmedi-179	92	17	of	of	ADP
clinmedi-179	92	18	our	our	PRON
clinmedi-179	92	19	small	small	ADJ
clinmedi-179	92	20	number	number	NOUN
clinmedi-179	92	21	of	of	ADP
clinmedi-179	92	22	patients	patient	NOUN
clinmedi-179	92	23	.	.	PUNCT
clinmedi-179	93	1	other	other	ADJ
clinmedi-179	93	2	studies	study	NOUN
clinmedi-179	93	3	utilized	utilize	VERB
clinmedi-179	93	4	more	more	ADV
clinmedi-179	93	5	aggressive	aggressive	ADJ
clinmedi-179	93	6	therapeutic	therapeutic	ADJ
clinmedi-179	93	7	regimens	regimen	NOUN
clinmedi-179	93	8	for	for	ADP
clinmedi-179	93	9	more	more	ADV
clinmedi-179	93	10	aggressive	aggressive	ADJ
clinmedi-179	93	11	tumors	tumor	NOUN
clinmedi-179	93	12	.	.	PUNCT
clinmedi-179	94	1	the	the	DET
clinmedi-179	94	2	cmi	cmi	PROPN
clinmedi-179	94	3	04	04	PROPN
clinmedi-179	94	4	(	(	PUNCT
clinmedi-179	94	5	02	02	NUM
clinmedi-179	94	6	)	)	PUNCT
clinmedi-179	94	7	,	,	PUNCT
clinmedi-179	94	8	378−386	378−386	NUM
clinmedi-179	94	9	cmi	cmi	PROPN
clinmedi-179	94	10	journal	journal	PROPN
clinmedi-179	94	11	384	384	NUM
clinmedi-179	94	12	cmi	cmi	PROPN
clinmedi-179	94	13	journal	journal	PROPN
clinmedi-179	94	14	kazumi	kazumi	PROPN
clinmedi-179	94	15	kawase	kawase	PROPN
clinmedi-179	94	16	et	et	PROPN
clinmedi-179	94	17	al	al	PROPN
clinmedi-179	94	18	.	.	PROPN
clinmedi-179	94	19	addition	addition	NOUN
clinmedi-179	94	20	of	of	ADP
clinmedi-179	94	21	pertuzumab	pertuzumab	NOUN
clinmedi-179	94	22	to	to	ADP
clinmedi-179	94	23	trastuzumab	trastuzumab	NOUN
clinmedi-179	94	24	in	in	ADP
clinmedi-179	94	25	combination	combination	NOUN
clinmedi-179	94	26	chemotherapy	chemotherapy	NOUN
clinmedi-179	94	27	significantly	significantly	ADV
clinmedi-179	94	28	improved	improve	VERB
clinmedi-179	94	29	the	the	DET
clinmedi-179	94	30	survival	survival	NOUN
clinmedi-179	94	31	of	of	ADP
clinmedi-179	94	32	patients	patient	NOUN
clinmedi-179	94	33	with	with	ADP
clinmedi-179	94	34	high	high	ADJ
clinmedi-179	94	35	-	-	PUNCT
clinmedi-179	94	36	risk	risk	NOUN
clinmedi-179	94	37	her2	her2	NOUN
clinmedi-179	94	38	+	+	CCONJ
clinmedi-179	94	39	breast	breast	NOUN
clinmedi-179	94	40	cancer	cancer	NOUN
clinmedi-179	94	41	.	.	PUNCT
clinmedi-179	95	1	18	18	NUM
clinmedi-179	95	2	the	the	DET
clinmedi-179	95	3	study	study	NOUN
clinmedi-179	95	4	which	which	PRON
clinmedi-179	95	5	compared	compare	VERB
clinmedi-179	95	6	dosedense	dosedense	NOUN
clinmedi-179	95	7	chemotherapy	chemotherapy	NOUN
clinmedi-179	95	8	(	(	PUNCT
clinmedi-179	95	9	either	either	CCONJ
clinmedi-179	95	10	ac	ac	PROPN
clinmedi-179	95	11	or	or	CCONJ
clinmedi-179	95	12	fec	fec	PROPN
clinmedi-179	95	13	)	)	PUNCT
clinmedi-179	95	14	with	with	ADP
clinmedi-179	95	15	standard	standard	ADJ
clinmedi-179	95	16	chemotherapy	chemotherapy	NOUN
clinmedi-179	95	17	in	in	ADP
clinmedi-179	95	18	conjunction	conjunction	NOUN
clinmedi-179	95	19	with	with	ADP
clinmedi-179	95	20	paclitaxel	paclitaxel	NOUN
clinmedi-179	95	21	and	and	CCONJ
clinmedi-179	95	22	trastuzumab	trastuzumab	NOUN
clinmedi-179	95	23	showed	show	VERB
clinmedi-179	95	24	little	little	ADJ
clinmedi-179	95	25	benefit	benefit	NOUN
clinmedi-179	95	26	in	in	ADP
clinmedi-179	95	27	patients	patient	NOUN
clinmedi-179	95	28	with	with	ADP
clinmedi-179	95	29	her2	her2	PROPN
clinmedi-179	95	30	+	+	CCONJ
clinmedi-179	95	31	breast	breast	NOUN
clinmedi-179	95	32	cancer	cancer	NOUN
clinmedi-179	95	33	.	.	PUNCT
clinmedi-179	96	1	19	19	NUM
clinmedi-179	96	2	however	however	ADV
clinmedi-179	96	3	,	,	PUNCT
clinmedi-179	96	4	dose	dose	ADJ
clinmedi-179	96	5	de	de	PROPN
clinmedi-179	96	6	-	-	NOUN
clinmedi-179	96	7	escalation	escalation	NOUN
clinmedi-179	96	8	therapy	therapy	NOUN
clinmedi-179	96	9	has	have	AUX
clinmedi-179	96	10	also	also	ADV
clinmedi-179	96	11	been	be	AUX
clinmedi-179	96	12	suggested	suggest	VERB
clinmedi-179	96	13	as	as	ADP
clinmedi-179	96	14	a	a	DET
clinmedi-179	96	15	means	means	NOUN
clinmedi-179	96	16	of	of	ADP
clinmedi-179	96	17	reducing	reduce	VERB
clinmedi-179	96	18	adverse	adverse	ADJ
clinmedi-179	96	19	events	event	NOUN
clinmedi-179	96	20	.	.	PUNCT
clinmedi-179	97	1	hence	hence	ADV
clinmedi-179	97	2	,	,	PUNCT
clinmedi-179	97	3	dose	dose	ADJ
clinmedi-179	97	4	de	de	NOUN
clinmedi-179	97	5	-	-	NOUN
clinmedi-179	97	6	escalation	escalation	ADJ
clinmedi-179	97	7	therapies	therapy	NOUN
clinmedi-179	97	8	were	be	AUX
clinmedi-179	97	9	explored	explore	VERB
clinmedi-179	97	10	to	to	PART
clinmedi-179	97	11	reduce	reduce	VERB
clinmedi-179	97	12	the	the	DET
clinmedi-179	97	13	adverse	adverse	ADJ
clinmedi-179	97	14	effects	effect	NOUN
clinmedi-179	97	15	of	of	ADP
clinmedi-179	97	16	chemotherapy	chemotherapy	NOUN
clinmedi-179	97	17	.	.	PUNCT
clinmedi-179	98	1	cardiac	cardiac	ADJ
clinmedi-179	98	2	toxicity	toxicity	NOUN
clinmedi-179	98	3	is	be	AUX
clinmedi-179	98	4	the	the	DET
clinmedi-179	98	5	most	most	ADV
clinmedi-179	98	6	serious	serious	ADJ
clinmedi-179	98	7	adverse	adverse	ADJ
clinmedi-179	98	8	event	event	NOUN
clinmedi-179	98	9	following	follow	VERB
clinmedi-179	98	10	anthracycline	anthracycline	PROPN
clinmedi-179	98	11	and	and	CCONJ
clinmedi-179	98	12	antiher2	antiher2	PROPN
clinmedi-179	98	13	treatment	treatment	NOUN
clinmedi-179	98	14	.	.	PUNCT
clinmedi-179	99	1	the	the	DET
clinmedi-179	99	2	risk	risk	NOUN
clinmedi-179	99	3	of	of	ADP
clinmedi-179	99	4	anthracyclineinduced	anthracyclineinduce	VERB
clinmedi-179	99	5	cardiotoxicity	cardiotoxicity	NOUN
clinmedi-179	99	6	is	be	AUX
clinmedi-179	99	7	dose	dose	NOUN
clinmedi-179	99	8	-	-	PUNCT
clinmedi-179	99	9	dependent	dependent	ADJ
clinmedi-179	99	10	and	and	CCONJ
clinmedi-179	99	11	increases	increase	VERB
clinmedi-179	99	12	with	with	ADP
clinmedi-179	99	13	the	the	DET
clinmedi-179	99	14	cumulative	cumulative	ADJ
clinmedi-179	99	15	dose	dose	NOUN
clinmedi-179	99	16	.	.	PUNCT
clinmedi-179	100	1	to	to	PART
clinmedi-179	100	2	avoid	avoid	VERB
clinmedi-179	100	3	cardiac	cardiac	ADJ
clinmedi-179	100	4	toxicity	toxicity	NOUN
clinmedi-179	100	5	,	,	PUNCT
clinmedi-179	100	6	several	several	ADJ
clinmedi-179	100	7	studies	study	NOUN
clinmedi-179	100	8	have	have	AUX
clinmedi-179	100	9	utilized	utilize	VERB
clinmedi-179	100	10	fec75	fec75	PROPN
clinmedi-179	100	11	,	,	PUNCT
clinmedi-179	100	12	3	3	NUM
clinmedi-179	100	13	,	,	PUNCT
clinmedi-179	100	14	20	20	NUM
clinmedi-179	100	15	which	which	PRON
clinmedi-179	100	16	was	be	AUX
clinmedi-179	100	17	also	also	ADV
clinmedi-179	100	18	applied	apply	VERB
clinmedi-179	100	19	in	in	ADP
clinmedi-179	100	20	our	our	PRON
clinmedi-179	100	21	study	study	NOUN
clinmedi-179	100	22	.	.	PUNCT
clinmedi-179	101	1	in	in	ADP
clinmedi-179	101	2	addition	addition	NOUN
clinmedi-179	101	3	,	,	PUNCT
clinmedi-179	101	4	anthracycline	anthracycline	NOUN
clinmedi-179	101	5	-	-	PUNCT
clinmedi-179	101	6	free	free	ADJ
clinmedi-179	101	7	regimens	regimen	NOUN
clinmedi-179	101	8	have	have	AUX
clinmedi-179	101	9	been	be	AUX
clinmedi-179	101	10	tested	test	VERB
clinmedi-179	101	11	for	for	ADP
clinmedi-179	101	12	the	the	DET
clinmedi-179	101	13	treatment	treatment	NOUN
clinmedi-179	101	14	of	of	ADP
clinmedi-179	101	15	selected	select	VERB
clinmedi-179	101	16	low	low	ADJ
clinmedi-179	101	17	-	-	PUNCT
clinmedi-179	101	18	risk	risk	NOUN
clinmedi-179	101	19	tumors	tumor	NOUN
clinmedi-179	101	20	.	.	PUNCT
clinmedi-179	102	1	in	in	ADP
clinmedi-179	102	2	the	the	DET
clinmedi-179	102	3	neoadjuvant	neoadjuvant	ADJ
clinmedi-179	102	4	setting	setting	NOUN
clinmedi-179	102	5	,	,	PUNCT
clinmedi-179	102	6	a	a	DET
clinmedi-179	102	7	japanese	japanese	ADJ
clinmedi-179	102	8	trial	trial	NOUN
clinmedi-179	102	9	that	that	PRON
clinmedi-179	102	10	included	include	VERB
clinmedi-179	102	11	patients	patient	NOUN
clinmedi-179	102	12	with	with	ADP
clinmedi-179	102	13	low	low	ADJ
clinmedi-179	102	14	-	-	PUNCT
clinmedi-179	102	15	risk	risk	NOUN
clinmedi-179	102	16	hr	hr	NOUN
clinmedi-179	102	17	–	–	PUNCT
clinmedi-179	102	18	/her2	/her2	PUNCT
clinmedi-179	102	19	+	+	CCONJ
clinmedi-179	102	20	tumors	tumor	NOUN
clinmedi-179	102	21	reported	report	VERB
clinmedi-179	102	22	a	a	DET
clinmedi-179	102	23	pcr	pcr	ADJ
clinmedi-179	102	24	rate	rate	NOUN
clinmedi-179	102	25	of	of	ADP
clinmedi-179	102	26	66.7	66.7	NUM
clinmedi-179	102	27	%	%	NOUN
clinmedi-179	102	28	using	use	VERB
clinmedi-179	102	29	an	an	DET
clinmedi-179	102	30	anthracycline	anthracycline	NOUN
clinmedi-179	102	31	-	-	PUNCT
clinmedi-179	102	32	free	free	ADJ
clinmedi-179	102	33	regimen	regiman	NOUN
clinmedi-179	102	34	of	of	ADP
clinmedi-179	102	35	nab	nab	NOUN
clinmedi-179	102	36	-	-	PUNCT
clinmedi-179	102	37	ptx	ptx	NOUN
clinmedi-179	102	38	260	260	NUM
clinmedi-179	102	39	mg	mg	PROPN
clinmedi-179	102	40	/	/	SYM
clinmedi-179	102	41	m	m	VERB
clinmedi-179	102	42	2	2	NUM
clinmedi-179	102	43	with	with	ADP
clinmedi-179	102	44	q3w	q3w	NOUN
clinmedi-179	102	45	trastuzumab	trastuzumab	NOUN
clinmedi-179	102	46	for	for	ADP
clinmedi-179	102	47	four	four	NUM
clinmedi-179	102	48	cycles	cycle	NOUN
clinmedi-179	102	49	.	.	PUNCT
clinmedi-179	103	1	21	21	NUM
clinmedi-179	103	2	most	most	ADJ
clinmedi-179	103	3	studies	study	NOUN
clinmedi-179	103	4	have	have	AUX
clinmedi-179	103	5	reported	report	VERB
clinmedi-179	103	6	acceptable	acceptable	ADJ
clinmedi-179	103	7	toxicity	toxicity	NOUN
clinmedi-179	103	8	profiles	profile	NOUN
clinmedi-179	103	9	in	in	ADP
clinmedi-179	103	10	terms	term	NOUN
clinmedi-179	103	11	of	of	ADP
clinmedi-179	103	12	adverse	adverse	ADJ
clinmedi-179	103	13	events	event	NOUN
clinmedi-179	103	14	associated	associate	VERB
clinmedi-179	103	15	with	with	ADP
clinmedi-179	103	16	nab	nab	NOUN
clinmedi-179	103	17	-	-	PUNCT
clinmedi-179	103	18	ptx	ptx	NOUN
clinmedi-179	103	19	.	.	PUNCT
clinmedi-179	103	20	7,15	7,15	NUM
clinmedi-179	104	1	however	however	ADV
clinmedi-179	104	2	,	,	PUNCT
clinmedi-179	104	3	according	accord	VERB
clinmedi-179	104	4	to	to	ADP
clinmedi-179	104	5	the	the	DET
clinmedi-179	104	6	drug	drug	NOUN
clinmedi-179	104	7	use	use	NOUN
clinmedi-179	104	8	survey	survey	NOUN
clinmedi-179	104	9	for	for	ADP
clinmedi-179	104	10	nab	nab	NOUN
clinmedi-179	104	11	-	-	PUNCT
clinmedi-179	104	12	ptx	ptx	NOUN
clinmedi-179	104	13	conducted	conduct	VERB
clinmedi-179	104	14	in	in	ADP
clinmedi-179	104	15	japan	japan	PROPN
clinmedi-179	104	16	based	base	VERB
clinmedi-179	104	17	on	on	ADP
clinmedi-179	104	18	the	the	DET
clinmedi-179	104	19	criteria	criterion	NOUN
clinmedi-179	104	20	for	for	ADP
clinmedi-179	104	21	approval	approval	NOUN
clinmedi-179	104	22	during	during	ADP
clinmedi-179	104	23	2010–2011	2010–2011	NUM
clinmedi-179	104	24	,	,	PUNCT
clinmedi-179	104	25	numerous	numerous	ADJ
clinmedi-179	104	26	adverse	adverse	ADJ
clinmedi-179	104	27	events	event	NOUN
clinmedi-179	104	28	were	be	AUX
clinmedi-179	104	29	observed	observe	VERB
clinmedi-179	104	30	.	.	PUNCT
clinmedi-179	105	1	in	in	ADP
clinmedi-179	105	2	this	this	DET
clinmedi-179	105	3	survey	survey	NOUN
clinmedi-179	105	4	,	,	PUNCT
clinmedi-179	105	5	934	934	NUM
clinmedi-179	105	6	patients	patient	NOUN
clinmedi-179	105	7	were	be	AUX
clinmedi-179	105	8	evaluated	evaluate	VERB
clinmedi-179	105	9	to	to	PART
clinmedi-179	105	10	determine	determine	VERB
clinmedi-179	105	11	the	the	DET
clinmedi-179	105	12	safety	safety	NOUN
clinmedi-179	105	13	profiles	profile	NOUN
clinmedi-179	105	14	of	of	ADP
clinmedi-179	105	15	a	a	DET
clinmedi-179	105	16	q3w	q3w	NOUN
clinmedi-179	105	17	nab	nab	NOUN
clinmedi-179	105	18	-	-	PUNCT
clinmedi-179	105	19	ptx	ptx	NOUN
clinmedi-179	105	20	dose	dose	NOUN
clinmedi-179	105	21	of	of	ADP
clinmedi-179	105	22	260	260	NUM
clinmedi-179	105	23	mg	mg	PROPN
clinmedi-179	105	24	/	/	SYM
clinmedi-179	105	25	m	m	PROPN
clinmedi-179	105	26	2	2	NUM
clinmedi-179	105	27	,	,	PUNCT
clinmedi-179	105	28	with	with	ADP
clinmedi-179	105	29	adverse	adverse	ADJ
clinmedi-179	105	30	events	event	NOUN
clinmedi-179	105	31	observed	observe	VERB
clinmedi-179	105	32	in	in	ADP
clinmedi-179	105	33	92.8	92.8	NUM
clinmedi-179	105	34	%	%	NOUN
clinmedi-179	105	35	of	of	ADP
clinmedi-179	105	36	patients	patient	NOUN
clinmedi-179	105	37	,	,	PUNCT
clinmedi-179	105	38	the	the	DET
clinmedi-179	105	39	most	most	ADV
clinmedi-179	105	40	common	common	ADJ
clinmedi-179	105	41	of	of	ADP
clinmedi-179	105	42	which	which	PRON
clinmedi-179	105	43	were	be	AUX
clinmedi-179	105	44	myelosuppression	myelosuppression	NOUN
clinmedi-179	105	45	and	and	CCONJ
clinmedi-179	105	46	psn	psn	PROPN
clinmedi-179	105	47	.	.	PROPN
clinmedi-179	106	1	22	22	NUM
clinmedi-179	107	1	both	both	DET
clinmedi-179	107	2	these	these	DET
clinmedi-179	107	3	adverse	adverse	ADJ
clinmedi-179	107	4	events	event	NOUN
clinmedi-179	107	5	occurred	occurred	AUX
clinmedi-179	107	6	frequently	frequently	ADV
clinmedi-179	107	7	following	follow	VERB
clinmedi-179	107	8	the	the	DET
clinmedi-179	107	9	second	second	ADJ
clinmedi-179	107	10	course	course	NOUN
clinmedi-179	107	11	of	of	ADP
clinmedi-179	107	12	treatment	treatment	NOUN
clinmedi-179	107	13	and	and	CCONJ
clinmedi-179	107	14	were	be	AUX
clinmedi-179	107	15	the	the	DET
clinmedi-179	107	16	primary	primary	ADJ
clinmedi-179	107	17	reason	reason	NOUN
clinmedi-179	107	18	for	for	ADP
clinmedi-179	107	19	discontinuation	discontinuation	NOUN
clinmedi-179	107	20	.	.	PUNCT
clinmedi-179	108	1	in	in	ADP
clinmedi-179	108	2	terms	term	NOUN
clinmedi-179	108	3	of	of	ADP
clinmedi-179	108	4	treatment	treatment	NOUN
clinmedi-179	108	5	schedule	schedule	NOUN
clinmedi-179	108	6	,	,	PUNCT
clinmedi-179	108	7	grade-3	grade-3	PRON
clinmedi-179	108	8	or	or	CCONJ
clinmedi-179	108	9	higher	high	ADJ
clinmedi-179	108	10	adverse	adverse	ADJ
clinmedi-179	108	11	events	event	NOUN
clinmedi-179	108	12	were	be	AUX
clinmedi-179	108	13	more	more	ADV
clinmedi-179	108	14	frequently	frequently	ADV
clinmedi-179	108	15	observed	observe	VERB
clinmedi-179	108	16	with	with	ADP
clinmedi-179	108	17	weekly	weekly	ADJ
clinmedi-179	108	18	administration	administration	NOUN
clinmedi-179	108	19	15	15	NUM
clinmedi-179	108	20	and	and	CCONJ
clinmedi-179	108	21	higher	high	ADJ
clinmedi-179	108	22	drug	drug	NOUN
clinmedi-179	108	23	doses	dose	NOUN
clinmedi-179	108	24	.	.	PUNCT
clinmedi-179	109	1	5,11,14	5,11,14	NUM
clinmedi-179	109	2	in	in	ADP
clinmedi-179	109	3	the	the	DET
clinmedi-179	109	4	geparsepto	geparsepto	NOUN
clinmedi-179	109	5	trial	trial	NOUN
clinmedi-179	109	6	,	,	PUNCT
clinmedi-179	109	7	long	long	ADJ
clinmedi-179	109	8	-	-	PUNCT
clinmedi-179	109	9	term	term	NOUN
clinmedi-179	109	10	follow	follow	NOUN
clinmedi-179	109	11	-	-	PUNCT
clinmedi-179	109	12	up	up	NOUN
clinmedi-179	109	13	of	of	ADP
clinmedi-179	109	14	treatment	treatment	NOUN
clinmedi-179	109	15	-	-	PUNCT
clinmedi-179	109	16	related	relate	VERB
clinmedi-179	109	17	psn	psn	NOUN
clinmedi-179	109	18	led	lead	VERB
clinmedi-179	109	19	to	to	ADP
clinmedi-179	109	20	a	a	DET
clinmedi-179	109	21	significant	significant	ADJ
clinmedi-179	109	22	decrease	decrease	NOUN
clinmedi-179	109	23	in	in	ADP
clinmedi-179	109	24	the	the	DET
clinmedi-179	109	25	median	median	ADJ
clinmedi-179	109	26	time	time	NOUN
clinmedi-179	109	27	to	to	PART
clinmedi-179	109	28	resolve	resolve	VERB
clinmedi-179	109	29	psn	psn	NOUN
clinmedi-179	109	30	following	follow	VERB
clinmedi-179	109	31	nabptx	nabptx	PROPN
clinmedi-179	109	32	125	125	NUM
clinmedi-179	109	33	mg	mg	PROPN
clinmedi-179	109	34	/	/	SYM
clinmedi-179	109	35	m	m	VERB
clinmedi-179	109	36	2	2	NUM
clinmedi-179	109	37	as	as	SCONJ
clinmedi-179	109	38	compared	compare	VERB
clinmedi-179	109	39	to	to	ADP
clinmedi-179	109	40	nab	nab	VERB
clinmedi-179	109	41	-	-	PUNCT
clinmedi-179	109	42	ptx	ptx	NOUN
clinmedi-179	109	43	150	150	NUM
clinmedi-179	109	44	mg	mg	NUM
clinmedi-179	109	45	/	/	SYM
clinmedi-179	109	46	m	m	PROPN
clinmedi-179	109	47	2	2	NUM
clinmedi-179	109	48	.	.	PUNCT
clinmedi-179	110	1	nab	nab	ADJ
clinmedi-179	110	2	-	-	PUNCT
clinmedi-179	110	3	ptx	ptx	NOUN
clinmedi-179	110	4	combination	combination	NOUN
clinmedi-179	110	5	therapy	therapy	NOUN
clinmedi-179	110	6	with	with	ADP
clinmedi-179	110	7	other	other	ADJ
clinmedi-179	110	8	agents	agent	NOUN
clinmedi-179	110	9	such	such	ADJ
clinmedi-179	110	10	as	as	ADP
clinmedi-179	110	11	bevacizumab	bevacizumab	NOUN
clinmedi-179	110	12	or	or	CCONJ
clinmedi-179	110	13	atezolizumab	atezolizumab	NOUN
clinmedi-179	110	14	resulted	result	VERB
clinmedi-179	110	15	in	in	ADP
clinmedi-179	110	16	a	a	DET
clinmedi-179	110	17	higher	high	ADJ
clinmedi-179	110	18	rate	rate	NOUN
clinmedi-179	110	19	of	of	ADP
clinmedi-179	110	20	discontinuation	discontinuation	NOUN
clinmedi-179	110	21	or	or	CCONJ
clinmedi-179	110	22	reduction	reduction	NOUN
clinmedi-179	110	23	.	.	PUNCT
clinmedi-179	111	1	23,24	23,24	NUM
clinmedi-179	111	2	in	in	ADP
clinmedi-179	111	3	our	our	PRON
clinmedi-179	111	4	study	study	NOUN
clinmedi-179	111	5	,	,	PUNCT
clinmedi-179	111	6	despite	despite	SCONJ
clinmedi-179	111	7	the	the	DET
clinmedi-179	111	8	low	low	ADV
clinmedi-179	111	9	-	-	PUNCT
clinmedi-179	111	10	dose	dose	NOUN
clinmedi-179	111	11	administration	administration	NOUN
clinmedi-179	111	12	of	of	ADP
clinmedi-179	111	13	nab	nab	NOUN
clinmedi-179	111	14	-	-	PUNCT
clinmedi-179	111	15	ptx	ptx	NOUN
clinmedi-179	111	16	,	,	PUNCT
clinmedi-179	111	17	55.0	55.0	NUM
clinmedi-179	111	18	%	%	NOUN
clinmedi-179	111	19	of	of	ADP
clinmedi-179	111	20	patients	patient	NOUN
clinmedi-179	111	21	reported	report	VERB
clinmedi-179	111	22	psn	psn	PROPN
clinmedi-179	111	23	,	,	PUNCT
clinmedi-179	111	24	and	and	CCONJ
clinmedi-179	111	25	18.5	18.5	NUM
clinmedi-179	111	26	%	%	NOUN
clinmedi-179	111	27	continued	continue	VERB
clinmedi-179	111	28	to	to	PART
clinmedi-179	111	29	be	be	AUX
clinmedi-179	111	30	symptomatic	symptomatic	ADJ
clinmedi-179	111	31	at	at	ADP
clinmedi-179	111	32	36	36	NUM
clinmedi-179	111	33	months	month	NOUN
clinmedi-179	111	34	following	follow	VERB
clinmedi-179	111	35	chemotherapy	chemotherapy	NOUN
clinmedi-179	111	36	.	.	PUNCT
clinmedi-179	112	1	most	most	ADJ
clinmedi-179	112	2	studies	study	NOUN
clinmedi-179	112	3	have	have	AUX
clinmedi-179	112	4	reported	report	VERB
clinmedi-179	112	5	psn	psn	NOUN
clinmedi-179	112	6	as	as	ADP
clinmedi-179	112	7	reversible	reversible	ADJ
clinmedi-179	112	8	,	,	PUNCT
clinmedi-179	112	9	whereas	whereas	SCONJ
clinmedi-179	112	10	in	in	ADP
clinmedi-179	112	11	our	our	PRON
clinmedi-179	112	12	study	study	NOUN
clinmedi-179	112	13	,	,	PUNCT
clinmedi-179	112	14	even	even	ADV
clinmedi-179	112	15	low	low	ADV
clinmedi-179	112	16	-	-	PUNCT
clinmedi-179	112	17	dose	dose	NOUN
clinmedi-179	112	18	ptx	ptx	NOUN
clinmedi-179	112	19	caused	cause	VERB
clinmedi-179	112	20	prolonged	prolonged	ADJ
clinmedi-179	112	21	psn	psn	NOUN
clinmedi-179	112	22	.	.	PUNCT
clinmedi-179	113	1	although	although	SCONJ
clinmedi-179	113	2	this	this	DET
clinmedi-179	113	3	analysis	analysis	NOUN
clinmedi-179	113	4	was	be	AUX
clinmedi-179	113	5	conducted	conduct	VERB
clinmedi-179	113	6	as	as	ADP
clinmedi-179	113	7	a	a	DET
clinmedi-179	113	8	phase	phase	NOUN
clinmedi-179	113	9	ii	ii	PROPN
clinmedi-179	113	10	study	study	NOUN
clinmedi-179	113	11	,	,	PUNCT
clinmedi-179	113	12	the	the	DET
clinmedi-179	113	13	results	result	NOUN
clinmedi-179	113	14	reflected	reflect	VERB
clinmedi-179	113	15	real	real	ADJ
clinmedi-179	113	16	-	-	PUNCT
clinmedi-179	113	17	world	world	NOUN
clinmedi-179	113	18	data	datum	NOUN
clinmedi-179	113	19	.	.	PUNCT
clinmedi-179	114	1	de	de	ADJ
clinmedi-179	114	2	-	-	NOUN
clinmedi-179	114	3	escalation	escalation	NOUN
clinmedi-179	114	4	treatment	treatment	NOUN
clinmedi-179	114	5	has	have	AUX
clinmedi-179	114	6	also	also	ADV
clinmedi-179	114	7	been	be	AUX
clinmedi-179	114	8	assessed	assess	VERB
clinmedi-179	114	9	to	to	PART
clinmedi-179	114	10	reduce	reduce	VERB
clinmedi-179	114	11	adverse	adverse	ADJ
clinmedi-179	114	12	events	event	NOUN
clinmedi-179	114	13	resulting	result	VERB
clinmedi-179	114	14	from	from	ADP
clinmedi-179	114	15	nab	nab	NOUN
clinmedi-179	114	16	-	-	PUNCT
clinmedi-179	114	17	ptx	ptx	NOUN
clinmedi-179	114	18	.	.	PUNCT
clinmedi-179	115	1	in	in	ADP
clinmedi-179	115	2	the	the	DET
clinmedi-179	115	3	metastatic	metastatic	ADJ
clinmedi-179	115	4	setting	setting	NOUN
clinmedi-179	115	5	,	,	PUNCT
clinmedi-179	115	6	a	a	DET
clinmedi-179	115	7	randomized	randomized	ADJ
clinmedi-179	115	8	phase	phase	NOUN
clinmedi-179	115	9	ii	ii	NOUN
clinmedi-179	115	10	trial	trial	NOUN
clinmedi-179	115	11	in	in	ADP
clinmedi-179	115	12	japan	japan	PROPN
clinmedi-179	115	13	was	be	AUX
clinmedi-179	115	14	performed	perform	VERB
clinmedi-179	115	15	to	to	PART
clinmedi-179	115	16	compare	compare	VERB
clinmedi-179	115	17	three	three	NUM
clinmedi-179	115	18	different	different	ADJ
clinmedi-179	115	19	doses	dose	NOUN
clinmedi-179	115	20	of	of	ADP
clinmedi-179	115	21	q3w	q3w	NOUN
clinmedi-179	115	22	nab	nab	NOUN
clinmedi-179	115	23	-	-	PUNCT
clinmedi-179	115	24	ptx	ptx	NOUN
clinmedi-179	115	25	(	(	PUNCT
clinmedi-179	115	26	260	260	NUM
clinmedi-179	115	27	vs.	vs.	ADP
clinmedi-179	115	28	220	220	NUM
clinmedi-179	115	29	vs.	vs.	ADP
clinmedi-179	115	30	180	180	NUM
clinmedi-179	115	31	mg	mg	PROPN
clinmedi-179	115	32	/	/	SYM
clinmedi-179	115	33	m	m	PROPN
clinmedi-179	115	34	2	2	NUM
clinmedi-179	115	35	)	)	PUNCT
clinmedi-179	115	36	in	in	ADP
clinmedi-179	115	37	patients	patient	NOUN
clinmedi-179	115	38	with	with	ADP
clinmedi-179	115	39	her2	her2	PROPN
clinmedi-179	115	40	–	–	PUNCT
clinmedi-179	115	41	metastatic	metastatic	ADJ
clinmedi-179	115	42	breast	breast	NOUN
clinmedi-179	115	43	cancer	cancer	NOUN
clinmedi-179	115	44	;	;	PUNCT
clinmedi-179	115	45	the	the	DET
clinmedi-179	115	46	results	result	NOUN
clinmedi-179	115	47	showed	show	VERB
clinmedi-179	115	48	that	that	SCONJ
clinmedi-179	115	49	the	the	DET
clinmedi-179	115	50	optimal	optimal	ADJ
clinmedi-179	115	51	treatment	treatment	NOUN
clinmedi-179	115	52	dose	dose	NOUN
clinmedi-179	115	53	was	be	AUX
clinmedi-179	115	54	180	180	NUM
clinmedi-179	115	55	mg	mg	NUM
clinmedi-179	115	56	/	/	SYM
clinmedi-179	115	57	m	m	PROPN
clinmedi-179	115	58	2	2	NUM
clinmedi-179	115	59	.	.	PUNCT
clinmedi-179	116	1	25	25	NUM
clinmedi-179	116	2	however	however	ADV
clinmedi-179	116	3	,	,	PUNCT
clinmedi-179	116	4	to	to	ADP
clinmedi-179	116	5	date	date	NOUN
clinmedi-179	116	6	,	,	PUNCT
clinmedi-179	116	7	no	no	DET
clinmedi-179	116	8	study	study	NOUN
clinmedi-179	116	9	of	of	ADP
clinmedi-179	116	10	de	de	NOUN
clinmedi-179	116	11	-	-	NOUN
clinmedi-179	116	12	escalation	escalation	ADJ
clinmedi-179	116	13	nab	nab	NOUN
clinmedi-179	116	14	-	-	PUNCT
clinmedi-179	116	15	ptx	ptx	NOUN
clinmedi-179	116	16	has	have	AUX
clinmedi-179	116	17	been	be	AUX
clinmedi-179	116	18	conducted	conduct	VERB
clinmedi-179	116	19	in	in	ADP
clinmedi-179	116	20	the	the	DET
clinmedi-179	116	21	neoadjuvant	neoadjuvant	ADJ
clinmedi-179	116	22	setting	setting	NOUN
clinmedi-179	116	23	.	.	PUNCT
clinmedi-179	117	1	in	in	ADP
clinmedi-179	117	2	our	our	PRON
clinmedi-179	117	3	study	study	NOUN
clinmedi-179	117	4	,	,	PUNCT
clinmedi-179	117	5	the	the	DET
clinmedi-179	117	6	pcr	pcr	NOUN
clinmedi-179	117	7	rates	rate	NOUN
clinmedi-179	117	8	were	be	AUX
clinmedi-179	117	9	37.5	37.5	NUM
clinmedi-179	117	10	%	%	NOUN
clinmedi-179	117	11	(	(	PUNCT
clinmedi-179	117	12	hr	hr	NOUN
clinmedi-179	117	13	+	+	NOUN
clinmedi-179	117	14	/her2	/her2	PUNCT
clinmedi-179	117	15	+	+	CCONJ
clinmedi-179	117	16	)	)	PUNCT
clinmedi-179	117	17	and	and	CCONJ
clinmedi-179	117	18	85.7	85.7	NUM
clinmedi-179	117	19	%	%	NOUN
clinmedi-179	117	20	(	(	PUNCT
clinmedi-179	117	21	hr	hr	NOUN
clinmedi-179	117	22	–	–	PUNCT
clinmedi-179	117	23	/her2	/her2	PUNCT
clinmedi-179	117	24	+	+	CCONJ
clinmedi-179	117	25	)	)	PUNCT
clinmedi-179	117	26	with	with	ADP
clinmedi-179	117	27	concurrent	concurrent	ADJ
clinmedi-179	117	28	administration	administration	NOUN
clinmedi-179	117	29	of	of	ADP
clinmedi-179	117	30	nab	nab	NOUN
clinmedi-179	117	31	-	-	PUNCT
clinmedi-179	117	32	ptx	ptx	NOUN
clinmedi-179	117	33	220	220	NUM
clinmedi-179	117	34	mg	mg	PROPN
clinmedi-179	117	35	/	/	SYM
clinmedi-179	117	36	m	m	PROPN
clinmedi-179	117	37	2	2	NUM
clinmedi-179	117	38	and	and	CCONJ
clinmedi-179	117	39	trastuzumab	trastuzumab	NOUN
clinmedi-179	117	40	,	,	PUNCT
clinmedi-179	117	41	respectively	respectively	ADV
clinmedi-179	117	42	,	,	PUNCT
clinmedi-179	117	43	which	which	PRON
clinmedi-179	117	44	is	be	AUX
clinmedi-179	117	45	comparable	comparable	ADJ
clinmedi-179	117	46	or	or	CCONJ
clinmedi-179	117	47	even	even	ADV
clinmedi-179	117	48	better	well	ADJ
clinmedi-179	117	49	than	than	ADP
clinmedi-179	117	50	those	those	PRON
clinmedi-179	117	51	reported	report	VERB
clinmedi-179	117	52	in	in	ADP
clinmedi-179	117	53	other	other	ADJ
clinmedi-179	117	54	studies	study	NOUN
clinmedi-179	117	55	using	use	VERB
clinmedi-179	117	56	the	the	DET
clinmedi-179	117	57	standard	standard	ADJ
clinmedi-179	117	58	dose	dose	NOUN
clinmedi-179	117	59	of	of	ADP
clinmedi-179	117	60	anthracycline	anthracycline	NOUN
clinmedi-179	117	61	and	and	CCONJ
clinmedi-179	117	62	nabptx	nabptx	PROPN
clinmedi-179	117	63	.	.	PUNCT
clinmedi-179	118	1	because	because	SCONJ
clinmedi-179	118	2	of	of	ADP
clinmedi-179	118	3	the	the	DET
clinmedi-179	118	4	expected	expect	VERB
clinmedi-179	118	5	improved	improved	ADJ
clinmedi-179	118	6	outcomes	outcome	NOUN
clinmedi-179	118	7	,	,	PUNCT
clinmedi-179	118	8	low	low	ADJ
clinmedi-179	118	9	-	-	PUNCT
clinmedi-179	118	10	dose	dose	NOUN
clinmedi-179	118	11	nab	nab	NOUN
clinmedi-179	118	12	-	-	PUNCT
clinmedi-179	118	13	ptx	ptx	NOUN
clinmedi-179	118	14	can	can	AUX
clinmedi-179	118	15	be	be	AUX
clinmedi-179	118	16	considered	consider	VERB
clinmedi-179	118	17	an	an	DET
clinmedi-179	118	18	effective	effective	ADJ
clinmedi-179	118	19	chemotherapeutic	chemotherapeutic	ADJ
clinmedi-179	118	20	agent	agent	NOUN
clinmedi-179	118	21	.	.	PUNCT
clinmedi-179	119	1	our	our	PRON
clinmedi-179	119	2	study	study	NOUN
clinmedi-179	119	3	had	have	VERB
clinmedi-179	119	4	some	some	DET
clinmedi-179	119	5	limitations	limitation	NOUN
clinmedi-179	119	6	.	.	PUNCT
clinmedi-179	120	1	first	first	ADV
clinmedi-179	120	2	,	,	PUNCT
clinmedi-179	120	3	this	this	PRON
clinmedi-179	120	4	was	be	AUX
clinmedi-179	120	5	a	a	DET
clinmedi-179	120	6	single	single	ADJ
clinmedi-179	120	7	-	-	PUNCT
clinmedi-179	120	8	institution	institution	NOUN
clinmedi-179	120	9	study	study	NOUN
clinmedi-179	120	10	with	with	ADP
clinmedi-179	120	11	a	a	DET
clinmedi-179	120	12	limited	limited	ADJ
clinmedi-179	120	13	number	number	NOUN
clinmedi-179	120	14	of	of	ADP
clinmedi-179	120	15	patients	patient	NOUN
clinmedi-179	120	16	.	.	PUNCT
clinmedi-179	121	1	hence	hence	ADV
clinmedi-179	121	2	,	,	PUNCT
clinmedi-179	121	3	there	there	PRON
clinmedi-179	121	4	was	be	VERB
clinmedi-179	121	5	likely	likely	ADJ
clinmedi-179	121	6	some	some	DET
clinmedi-179	121	7	bias	bias	NOUN
clinmedi-179	121	8	.	.	PUNCT
clinmedi-179	122	1	on	on	ADP
clinmedi-179	122	2	the	the	DET
clinmedi-179	122	3	basis	basis	NOUN
clinmedi-179	122	4	of	of	ADP
clinmedi-179	122	5	our	our	PRON
clinmedi-179	122	6	results	result	NOUN
clinmedi-179	122	7	,	,	PUNCT
clinmedi-179	122	8	more	more	ADJ
clinmedi-179	122	9	number	number	NOUN
clinmedi-179	122	10	of	of	ADP
clinmedi-179	122	11	patients	patient	NOUN
clinmedi-179	122	12	need	need	VERB
clinmedi-179	122	13	to	to	PART
clinmedi-179	122	14	be	be	AUX
clinmedi-179	122	15	assessed	assess	VERB
clinmedi-179	122	16	.	.	PUNCT
clinmedi-179	123	1	second	second	ADV
clinmedi-179	123	2	,	,	PUNCT
clinmedi-179	123	3	psn	psn	PROPN
clinmedi-179	123	4	was	be	AUX
clinmedi-179	123	5	diagnosed	diagnose	VERB
clinmedi-179	123	6	based	base	VERB
clinmedi-179	123	7	on	on	ADP
clinmedi-179	123	8	subjective	subjective	ADJ
clinmedi-179	123	9	assessment	assessment	NOUN
clinmedi-179	123	10	by	by	ADP
clinmedi-179	123	11	patients	patient	NOUN
clinmedi-179	123	12	and	and	CCONJ
clinmedi-179	123	13	physicians	physician	NOUN
clinmedi-179	123	14	.	.	PUNCT
clinmedi-179	124	1	the	the	DET
clinmedi-179	124	2	extent	extent	NOUN
clinmedi-179	124	3	of	of	ADP
clinmedi-179	124	4	toxicity	toxicity	NOUN
clinmedi-179	124	5	was	be	AUX
clinmedi-179	124	6	assessed	assess	VERB
clinmedi-179	124	7	using	use	VERB
clinmedi-179	124	8	the	the	DET
clinmedi-179	124	9	ctcae	ctcae	NOUN
clinmedi-179	124	10	criteria	criterion	NOUN
clinmedi-179	124	11	;	;	PUNCT
clinmedi-179	124	12	however	however	ADV
clinmedi-179	124	13	,	,	PUNCT
clinmedi-179	124	14	the	the	DET
clinmedi-179	124	15	toxicity	toxicity	NOUN
clinmedi-179	124	16	estimation	estimation	NOUN
clinmedi-179	124	17	may	may	AUX
clinmedi-179	124	18	have	have	AUX
clinmedi-179	124	19	changed	change	VERB
clinmedi-179	124	20	according	accord	VERB
clinmedi-179	124	21	to	to	ADP
clinmedi-179	124	22	each	each	DET
clinmedi-179	124	23	assessor	assessor	NOUN
clinmedi-179	124	24	.	.	PUNCT
clinmedi-179	125	1	in	in	ADP
clinmedi-179	125	2	conclusion	conclusion	NOUN
clinmedi-179	125	3	,	,	PUNCT
clinmedi-179	125	4	nac	nac	PROPN
clinmedi-179	125	5	with	with	ADP
clinmedi-179	125	6	low	low	ADV
clinmedi-179	125	7	-	-	PUNCT
clinmedi-179	125	8	dose	dose	VERB
clinmedi-179	125	9	q3w	q3w	NOUN
clinmedi-179	125	10	nab	nab	NOUN
clinmedi-179	125	11	-	-	PUNCT
clinmedi-179	125	12	ptx	ptx	NOUN
clinmedi-179	125	13	followed	follow	VERB
clinmedi-179	125	14	by	by	ADP
clinmedi-179	125	15	fec	fec	PROPN
clinmedi-179	125	16	demonstrated	demonstrate	VERB
clinmedi-179	125	17	favorable	favorable	ADJ
clinmedi-179	125	18	pcr	pcr	ADJ
clinmedi-179	125	19	rates	rate	NOUN
clinmedi-179	125	20	and	and	CCONJ
clinmedi-179	125	21	dfs	dfs	NOUN
clinmedi-179	125	22	,	,	PUNCT
clinmedi-179	125	23	particularly	particularly	ADV
clinmedi-179	125	24	in	in	ADP
clinmedi-179	125	25	patients	patient	NOUN
clinmedi-179	125	26	with	with	ADP
clinmedi-179	125	27	hr	hr	NOUN
clinmedi-179	125	28	–	–	PUNCT
clinmedi-179	125	29	/her2	/her2	PUNCT
clinmedi-179	126	1	+	+	NUM
clinmedi-179	126	2	breast	breast	NOUN
clinmedi-179	126	3	cancer	cancer	NOUN
clinmedi-179	126	4	.	.	PUNCT
clinmedi-179	127	1	psn	psn	PROPN
clinmedi-179	127	2	remains	remain	VERB
clinmedi-179	127	3	a	a	DET
clinmedi-179	127	4	concerning	concern	VERB
clinmedi-179	127	5	long	long	ADJ
clinmedi-179	127	6	-	-	PUNCT
clinmedi-179	127	7	term	term	NOUN
clinmedi-179	127	8	adverse	adverse	ADJ
clinmedi-179	127	9	effect	effect	NOUN
clinmedi-179	127	10	in	in	ADP
clinmedi-179	127	11	some	some	DET
clinmedi-179	127	12	patients	patient	NOUN
clinmedi-179	127	13	,	,	PUNCT
clinmedi-179	127	14	even	even	ADV
clinmedi-179	127	15	after	after	ADP
clinmedi-179	127	16	reducing	reduce	VERB
clinmedi-179	127	17	the	the	DET
clinmedi-179	127	18	nab	nab	ADJ
clinmedi-179	127	19	-	-	PUNCT
clinmedi-179	127	20	ptx	ptx	NOUN
clinmedi-179	127	21	administration	administration	NOUN
clinmedi-179	127	22	dose	dose	PROPN
clinmedi-179	127	23	.	.	PUNCT
clinmedi-179	128	1	acknowledgments	acknowledgment	NOUN
clinmedi-179	128	2	:	:	PUNCT
clinmedi-179	129	1	we	we	PRON
clinmedi-179	129	2	gratefully	gratefully	ADV
clinmedi-179	129	3	acknowledge	acknowledge	VERB
clinmedi-179	129	4	all	all	DET
clinmedi-179	129	5	patients	patient	NOUN
clinmedi-179	129	6	for	for	ADP
clinmedi-179	129	7	their	their	PRON
clinmedi-179	129	8	participation	participation	NOUN
clinmedi-179	129	9	and	and	CCONJ
clinmedi-179	129	10	contributions	contribution	NOUN
clinmedi-179	129	11	.	.	PUNCT
clinmedi-179	130	1	cmi	cmi	PROPN
clinmedi-179	130	2	04	04	PROPN
clinmedi-179	130	3	(	(	PUNCT
clinmedi-179	130	4	02	02	NUM
clinmedi-179	130	5	)	)	PUNCT
clinmedi-179	130	6	,	,	PUNCT
clinmedi-179	130	7	378−386	378−386	NUM
clinmedi-179	130	8	cmi	cmi	PROPN
clinmedi-179	130	9	journal	journal	PROPN
clinmedi-179	130	10	385	385	NUM
clinmedi-179	130	11	cmi	cmi	PROPN
clinmedi-179	130	12	journal	journal	PROPN
clinmedi-179	130	13	kazumi	kazumi	PROPN
clinmedi-179	130	14	kawase	kawase	PROPN
clinmedi-179	130	15	et	et	PROPN
clinmedi-179	130	16	al	al	PROPN
clinmedi-179	130	17	.	.	PROPN
clinmedi-179	130	18	references	reference	NOUN
clinmedi-179	130	19	1	1	NUM
clinmedi-179	130	20	.	.	PUNCT
clinmedi-179	131	1	abu	abu	PROPN
clinmedi-179	131	2	samaan	samaan	PROPN
clinmedi-179	131	3	tm	tm	PROPN
clinmedi-179	131	4	,	,	PUNCT
clinmedi-179	131	5	samec	samec	PROPN
clinmedi-179	131	6	m	m	PROPN
clinmedi-179	131	7	,	,	PUNCT
clinmedi-179	131	8	liskova	liskova	PROPN
clinmedi-179	131	9	a	a	PRON
clinmedi-179	131	10	,	,	PUNCT
clinmedi-179	131	11	kubatka	kubatka	PROPN
clinmedi-179	131	12	p	p	PROPN
clinmedi-179	131	13	,	,	PUNCT
clinmedi-179	131	14	büsselberg	büsselberg	PROPN
clinmedi-179	131	15	d.	d.	PROPN
clinmedi-179	131	16	paclitaxel	paclitaxel	PROPN
clinmedi-179	131	17	’s	’s	PART
clinmedi-179	131	18	mechanistic	mechanistic	ADJ
clinmedi-179	131	19	and	and	CCONJ
clinmedi-179	131	20	clinical	clinical	ADJ
clinmedi-179	131	21	effects	effect	NOUN
clinmedi-179	131	22	on	on	ADP
clinmedi-179	131	23	breast	breast	NOUN
clinmedi-179	131	24	cancer	cancer	NOUN
clinmedi-179	131	25	.	.	PUNCT
clinmedi-179	132	1	biomolecules	biomolecule	NOUN
clinmedi-179	132	2	2019	2019	NUM
clinmedi-179	132	3	;	;	PUNCT
clinmedi-179	132	4	9	9	NUM
clinmedi-179	132	5	:	:	SYM
clinmedi-179	132	6	789	789	NUM
clinmedi-179	132	7	.	.	X
clinmedi-179	132	8	2	2	X
clinmedi-179	132	9	.	.	X
clinmedi-179	132	10	yamada	yamada	PROPN
clinmedi-179	132	11	k	k	PROPN
clinmedi-179	132	12	,	,	PUNCT
clinmedi-179	132	13	yamamoto	yamamoto	PROPN
clinmedi-179	132	14	n	n	PROPN
clinmedi-179	132	15	,	,	PUNCT
clinmedi-179	132	16	yamada	yamada	PROPN
clinmedi-179	132	17	y	y	PROPN
clinmedi-179	132	18	,	,	PUNCT
clinmedi-179	132	19	mukohara	mukohara	PROPN
clinmedi-179	132	20	t	t	PROPN
clinmedi-179	132	21	,	,	PUNCT
clinmedi-179	132	22	minami	minami	PROPN
clinmedi-179	132	23	h	h	PROPN
clinmedi-179	132	24	,	,	PUNCT
clinmedi-179	132	25	tamura	tamura	ADJ
clinmedi-179	132	26	t.	t.	NOUN
clinmedi-179	132	27	phase	phase	NOUN
clinmedi-179	132	28	i	i	PRON
clinmedi-179	132	29	and	and	CCONJ
clinmedi-179	132	30	pharmacokinetic	pharmacokinetic	ADJ
clinmedi-179	132	31	study	study	NOUN
clinmedi-179	132	32	of	of	ADP
clinmedi-179	132	33	abi-007	abi-007	ADJ
clinmedi-179	132	34	,	,	PUNCT
clinmedi-179	132	35	albumin	albumin	NOUN
clinmedi-179	132	36	-	-	PUNCT
clinmedi-179	132	37	bound	bind	VERB
clinmedi-179	132	38	paclitaxel	paclitaxel	NOUN
clinmedi-179	132	39	,	,	PUNCT
clinmedi-179	132	40	administered	administer	VERB
clinmedi-179	132	41	every	every	DET
clinmedi-179	132	42	3	3	NUM
clinmedi-179	132	43	weeks	week	NOUN
clinmedi-179	132	44	in	in	ADP
clinmedi-179	132	45	japanese	japanese	ADJ
clinmedi-179	132	46	patients	patient	NOUN
clinmedi-179	132	47	with	with	ADP
clinmedi-179	132	48	solid	solid	ADJ
clinmedi-179	132	49	tumors	tumor	NOUN
clinmedi-179	132	50	.	.	PUNCT
clinmedi-179	133	1	jpn	jpn	PROPN
clinmedi-179	133	2	j	j	PROPN
clinmedi-179	133	3	clin	clin	PROPN
clinmedi-179	133	4	oncol	oncol	PROPN
clinmedi-179	133	5	2010	2010	NUM
clinmedi-179	133	6	;	;	PUNCT
clinmedi-179	133	7	40	40	NUM
clinmedi-179	133	8	:	:	PUNCT
clinmedi-179	133	9	404–11	404–11	X
clinmedi-179	133	10	.	.	PUNCT
clinmedi-179	134	1	3	3	X
clinmedi-179	134	2	.	.	X
clinmedi-179	134	3	buzdar	buzdar	PROPN
clinmedi-179	134	4	au	au	PROPN
clinmedi-179	134	5	,	,	PUNCT
clinmedi-179	134	6	ibrahim	ibrahim	PROPN
clinmedi-179	134	7	nk	nk	PROPN
clinmedi-179	134	8	,	,	PUNCT
clinmedi-179	134	9	francis	francis	PROPN
clinmedi-179	134	10	d	d	PROPN
clinmedi-179	134	11	et	et	PROPN
clinmedi-179	134	12	al	al	PROPN
clinmedi-179	134	13	.	.	PROPN
clinmedi-179	135	1	significantly	significantly	ADV
clinmedi-179	135	2	higher	high	ADJ
clinmedi-179	135	3	pathologic	pathologic	ADJ
clinmedi-179	135	4	complete	complete	ADJ
clinmedi-179	135	5	remission	remission	NOUN
clinmedi-179	135	6	rate	rate	NOUN
clinmedi-179	135	7	after	after	ADP
clinmedi-179	135	8	neoadjuvant	neoadjuvant	ADJ
clinmedi-179	135	9	therapy	therapy	NOUN
clinmedi-179	135	10	with	with	ADP
clinmedi-179	135	11	trastuzumab	trastuzumab	NOUN
clinmedi-179	135	12	,	,	PUNCT
clinmedi-179	135	13	paclitaxel	paclitaxel	NOUN
clinmedi-179	135	14	,	,	PUNCT
clinmedi-179	135	15	and	and	CCONJ
clinmedi-179	135	16	epirubicin	epirubicin	ADJ
clinmedi-179	135	17	chemotherapy	chemotherapy	NOUN
clinmedi-179	135	18	:	:	PUNCT
clinmedi-179	135	19	results	result	NOUN
clinmedi-179	135	20	of	of	ADP
clinmedi-179	135	21	a	a	DET
clinmedi-179	135	22	randomized	randomized	ADJ
clinmedi-179	135	23	trial	trial	NOUN
clinmedi-179	135	24	in	in	ADP
clinmedi-179	135	25	human	human	ADJ
clinmedi-179	135	26	epidermal	epidermal	ADJ
clinmedi-179	135	27	growth	growth	NOUN
clinmedi-179	135	28	factor	factor	NOUN
clinmedi-179	135	29	receptor	receptor	NOUN
clinmedi-179	135	30	2	2	NUM
clinmedi-179	135	31	–	–	PUNCT
clinmedi-179	135	32	positive	positive	ADJ
clinmedi-179	135	33	operable	operable	ADJ
clinmedi-179	135	34	breast	breast	NOUN
clinmedi-179	135	35	cancer	cancer	NOUN
clinmedi-179	135	36	.	.	PUNCT
clinmedi-179	136	1	j	j	PROPN
clinmedi-179	136	2	clin	clin	PROPN
clinmedi-179	136	3	oncol	oncol	PROPN
clinmedi-179	136	4	2005	2005	NUM
clinmedi-179	136	5	;	;	PUNCT
clinmedi-179	136	6	23	23	NUM
clinmedi-179	136	7	:	:	PUNCT
clinmedi-179	136	8	3676–85	3676–85	NUM
clinmedi-179	136	9	.	.	X
clinmedi-179	137	1	4	4	X
clinmedi-179	137	2	.	.	X
clinmedi-179	137	3	toi	toi	PROPN
clinmedi-179	137	4	m	m	PROPN
clinmedi-179	137	5	,	,	PUNCT
clinmedi-179	137	6	nakamura	nakamura	PROPN
clinmedi-179	137	7	s	s	PROPN
clinmedi-179	137	8	,	,	PUNCT
clinmedi-179	137	9	kuroi	kuroi	PROPN
clinmedi-179	137	10	k	k	PROPN
clinmedi-179	137	11	et	et	PROPN
clinmedi-179	137	12	al	al	PROPN
clinmedi-179	137	13	.	.	PROPN
clinmedi-179	137	14	phase	phase	PROPN
clinmedi-179	137	15	ii	ii	PROPN
clinmedi-179	137	16	study	study	NOUN
clinmedi-179	137	17	of	of	ADP
clinmedi-179	137	18	preoperative	preoperative	ADJ
clinmedi-179	137	19	sequential	sequential	ADJ
clinmedi-179	137	20	fec	fec	PROPN
clinmedi-179	137	21	and	and	CCONJ
clinmedi-179	137	22	docetaxel	docetaxel	NOUN
clinmedi-179	137	23	predicts	predict	NOUN
clinmedi-179	137	24	of	of	ADP
clinmedi-179	137	25	pathological	pathological	ADJ
clinmedi-179	137	26	response	response	NOUN
clinmedi-179	137	27	and	and	CCONJ
clinmedi-179	137	28	disease	disease	NOUN
clinmedi-179	137	29	free	free	ADJ
clinmedi-179	137	30	survival	survival	NOUN
clinmedi-179	137	31	.	.	PUNCT
clinmedi-179	138	1	breast	breast	NOUN
clinmedi-179	138	2	cancer	cancer	NOUN
clinmedi-179	138	3	res	re	NOUN
clinmedi-179	138	4	treat	treat	NOUN
clinmedi-179	138	5	2008	2008	NUM
clinmedi-179	138	6	;	;	PUNCT
clinmedi-179	138	7	110	110	NUM
clinmedi-179	138	8	:	:	PUNCT
clinmedi-179	139	1	531–9	531–9	NUM
clinmedi-179	139	2	5	5	NUM
clinmedi-179	139	3	.	.	PUNCT
clinmedi-179	140	1	yamamoto	yamamoto	PROPN
clinmedi-179	140	2	y	y	PROPN
clinmedi-179	140	3	,	,	PUNCT
clinmedi-179	140	4	kawano	kawano	PROPN
clinmedi-179	140	5	i	i	PRON
clinmedi-179	140	6	,	,	PUNCT
clinmedi-179	140	7	iwase	iwase	PROPN
clinmedi-179	140	8	h.	h.	PROPN
clinmedi-179	140	9	nabpaclitaxel	nabpaclitaxel	PROPN
clinmedi-179	140	10	for	for	ADP
clinmedi-179	140	11	the	the	DET
clinmedi-179	140	12	treatment	treatment	NOUN
clinmedi-179	140	13	of	of	ADP
clinmedi-179	140	14	breast	breast	NOUN
clinmedi-179	140	15	cancer	cancer	NOUN
clinmedi-179	140	16	:	:	PUNCT
clinmedi-179	140	17	efficacy	efficacy	NOUN
clinmedi-179	140	18	,	,	PUNCT
clinmedi-179	140	19	safety	safety	NOUN
clinmedi-179	140	20	,	,	PUNCT
clinmedi-179	140	21	and	and	CCONJ
clinmedi-179	140	22	approval	approval	NOUN
clinmedi-179	140	23	.	.	PUNCT
clinmedi-179	141	1	onco	onco	NOUN
clinmedi-179	141	2	targets	target	NOUN
clinmedi-179	141	3	ther	ther	ADV
clinmedi-179	141	4	2011	2011	NUM
clinmedi-179	141	5	;	;	PUNCT
clinmedi-179	141	6	4	4	NUM
clinmedi-179	141	7	:	:	SYM
clinmedi-179	141	8	123–36	123–36	NUM
clinmedi-179	141	9	.	.	PUNCT
clinmedi-179	142	1	6	6	NUM
clinmedi-179	142	2	.	.	X
clinmedi-179	142	3	martin	martin	PROPN
clinmedi-179	142	4	m.	m.	PROPN
clinmedi-179	142	5	nab	nab	PROPN
clinmedi-179	142	6	-	-	PUNCT
clinmedi-179	142	7	paclitaxel	paclitaxel	PROPN
clinmedi-179	142	8	dose	dose	NOUN
clinmedi-179	142	9	and	and	CCONJ
clinmedi-179	142	10	schedule	schedule	NOUN
clinmedi-179	142	11	in	in	ADP
clinmedi-179	142	12	breast	breast	NOUN
clinmedi-179	142	13	cancer	cancer	NOUN
clinmedi-179	142	14	.	.	PUNCT
clinmedi-179	143	1	breast	breast	NOUN
clinmedi-179	143	2	cancer	cancer	NOUN
clinmedi-179	143	3	res	re	NOUN
clinmedi-179	143	4	2015	2015	NUM
clinmedi-179	143	5	;	;	PUNCT
clinmedi-179	143	6	17	17	NUM
clinmedi-179	143	7	:	:	SYM
clinmedi-179	143	8	81	81	NUM
clinmedi-179	143	9	.	.	X
clinmedi-179	144	1	7	7	X
clinmedi-179	144	2	.	.	X
clinmedi-179	144	3	ueno	ueno	PROPN
clinmedi-179	144	4	nt	nt	PROPN
clinmedi-179	144	5	,	,	PUNCT
clinmedi-179	144	6	mamounas	mamounas	PROPN
clinmedi-179	144	7	ep	ep	PROPN
clinmedi-179	144	8	.	.	PROPN
clinmedi-179	144	9	neoadjuvant	neoadjuvant	PROPN
clinmedi-179	144	10	nabpaclitaxel	nabpaclitaxel	PROPN
clinmedi-179	144	11	in	in	ADP
clinmedi-179	144	12	the	the	DET
clinmedi-179	144	13	treatment	treatment	NOUN
clinmedi-179	144	14	of	of	ADP
clinmedi-179	144	15	breast	breast	NOUN
clinmedi-179	144	16	cancer	cancer	NOUN
clinmedi-179	144	17	.	.	PUNCT
clinmedi-179	145	1	breast	breast	NOUN
clinmedi-179	145	2	cancer	cancer	NOUN
clinmedi-179	145	3	res	re	NOUN
clinmedi-179	145	4	treat	treat	VERB
clinmedi-179	145	5	2016	2016	NUM
clinmedi-179	145	6	;	;	PUNCT
clinmedi-179	145	7	156	156	NUM
clinmedi-179	145	8	:	:	PUNCT
clinmedi-179	145	9	427–40	427–40	NUM
clinmedi-179	145	10	.	.	PUNCT
clinmedi-179	146	1	8	8	X
clinmedi-179	146	2	.	.	X
clinmedi-179	146	3	brufsky	brufsky	PROPN
clinmedi-179	146	4	a.	a.	PROPN
clinmedi-179	146	5	nab	nab	PROPN
clinmedi-179	146	6	-	-	PUNCT
clinmedi-179	146	7	paclitaxel	paclitaxel	PROPN
clinmedi-179	146	8	for	for	ADP
clinmedi-179	146	9	the	the	DET
clinmedi-179	146	10	treatment	treatment	NOUN
clinmedi-179	146	11	of	of	ADP
clinmedi-179	146	12	breast	breast	NOUN
clinmedi-179	146	13	cancer	cancer	NOUN
clinmedi-179	146	14	:	:	PUNCT
clinmedi-179	146	15	an	an	DET
clinmedi-179	146	16	update	update	NOUN
clinmedi-179	146	17	across	across	ADP
clinmedi-179	146	18	treatment	treatment	NOUN
clinmedi-179	146	19	settings	setting	NOUN
clinmedi-179	146	20	.	.	PUNCT
clinmedi-179	147	1	exp	exp	NOUN
clinmedi-179	147	2	hematol	hematol	NOUN
clinmedi-179	147	3	oncol	oncol	ADJ
clinmedi-179	147	4	2017	2017	NUM
clinmedi-179	147	5	;	;	PUNCT
clinmedi-179	147	6	6	6	NUM
clinmedi-179	147	7	:	:	SYM
clinmedi-179	147	8	1	1	NUM
clinmedi-179	147	9	-	-	SYM
clinmedi-179	147	10	15	15	NUM
clinmedi-179	147	11	.	.	NOUN
clinmedi-179	148	1	9	9	NUM
clinmedi-179	148	2	.	.	X
clinmedi-179	148	3	gradishar	gradishar	PROPN
clinmedi-179	148	4	wj	wj	PROPN
clinmedi-179	148	5	,	,	PUNCT
clinmedi-179	148	6	tjulandin	tjulandin	NOUN
clinmedi-179	148	7	s	s	PROPN
clinmedi-179	148	8	,	,	PUNCT
clinmedi-179	148	9	davidson	davidson	PROPN
clinmedi-179	148	10	n	n	PROPN
clinmedi-179	148	11	et	et	PROPN
clinmedi-179	148	12	al	al	PROPN
clinmedi-179	148	13	.	.	PROPN
clinmedi-179	148	14	phase	phase	NOUN
clinmedi-179	148	15	iii	iii	NUM
clinmedi-179	148	16	trial	trial	NOUN
clinmedi-179	148	17	of	of	ADP
clinmedi-179	148	18	nanoparticle	nanoparticle	NOUN
clinmedi-179	148	19	albumin	albumin	NOUN
clinmedi-179	148	20	-	-	PUNCT
clinmedi-179	148	21	bound	bind	VERB
clinmedi-179	148	22	paclitaxel	paclitaxel	NOUN
clinmedi-179	148	23	compared	compare	VERB
clinmedi-179	148	24	with	with	ADP
clinmedi-179	148	25	polyethylated	polyethylate	VERB
clinmedi-179	148	26	castor	castor	NOUN
clinmedi-179	148	27	oil	oil	NOUN
clinmedi-179	148	28	-	-	PUNCT
clinmedi-179	148	29	based	base	VERB
clinmedi-179	148	30	paclitaxel	paclitaxel	NOUN
clinmedi-179	148	31	in	in	ADP
clinmedi-179	148	32	women	woman	NOUN
clinmedi-179	148	33	with	with	ADP
clinmedi-179	148	34	breast	breast	NOUN
clinmedi-179	148	35	cancer	cancer	NOUN
clinmedi-179	148	36	.	.	PUNCT
clinmedi-179	149	1	j	j	PROPN
clinmedi-179	149	2	clin	clin	PROPN
clinmedi-179	149	3	oncol	oncol	PROPN
clinmedi-179	149	4	2005	2005	NUM
clinmedi-179	149	5	;	;	PUNCT
clinmedi-179	149	6	23	23	NUM
clinmedi-179	149	7	:	:	SYM
clinmedi-179	149	8	7794–803	7794–803	ADJ
clinmedi-179	149	9	.	.	PUNCT
clinmedi-179	149	10	10	10	NUM
clinmedi-179	149	11	.	.	PUNCT
clinmedi-179	150	1	gradishar	gradishar	PROPN
clinmedi-179	150	2	wj	wj	PROPN
clinmedi-179	150	3	,	,	PUNCT
clinmedi-179	150	4	krasnojon	krasnojon	PROPN
clinmedi-179	150	5	d	d	PROPN
clinmedi-179	150	6	,	,	PUNCT
clinmedi-179	150	7	cheporov	cheporov	PROPN
clinmedi-179	150	8	s	s	PROPN
clinmedi-179	150	9	et	et	PROPN
clinmedi-179	150	10	al	al	PROPN
clinmedi-179	150	11	.	.	PROPN
clinmedi-179	150	12	phase	phase	PROPN
clinmedi-179	150	13	ii	ii	NOUN
clinmedi-179	150	14	trial	trial	NOUN
clinmedi-179	150	15	of	of	ADP
clinmedi-179	150	16	nab	nab	NOUN
clinmedi-179	150	17	-	-	PUNCT
clinmedi-179	150	18	paclitaxel	paclitaxel	PROPN
clinmedi-179	150	19	compared	compare	VERB
clinmedi-179	150	20	with	with	ADP
clinmedi-179	150	21	docetaxel	docetaxel	NOUN
clinmedi-179	150	22	as	as	ADP
clinmedi-179	150	23	first	first	ADJ
clinmedi-179	150	24	-	-	PUNCT
clinmedi-179	150	25	line	line	NOUN
clinmedi-179	150	26	chemotherapy	chemotherapy	NOUN
clinmedi-179	150	27	in	in	ADP
clinmedi-179	150	28	patients	patient	NOUN
clinmedi-179	150	29	with	with	ADP
clinmedi-179	150	30	metastatic	metastatic	ADJ
clinmedi-179	150	31	breast	breast	NOUN
clinmedi-179	150	32	cancer	cancer	NOUN
clinmedi-179	150	33	:	:	PUNCT
clinmedi-179	150	34	final	final	ADJ
clinmedi-179	150	35	analysis	analysis	NOUN
clinmedi-179	150	36	of	of	ADP
clinmedi-179	150	37	overall	overall	ADJ
clinmedi-179	150	38	survival	survival	NOUN
clinmedi-179	150	39	.	.	PUNCT
clinmedi-179	151	1	clin	clin	PROPN
clinmedi-179	151	2	breast	breast	PROPN
clinmedi-179	151	3	cancer	cancer	PROPN
clinmedi-179	151	4	2012	2012	NUM
clinmedi-179	151	5	;	;	PUNCT
clinmedi-179	151	6	12	12	NUM
clinmedi-179	151	7	:	:	PUNCT
clinmedi-179	151	8	313–21	313–21	NUM
clinmedi-179	151	9	.	.	PUNCT
clinmedi-179	151	10	11	11	NUM
clinmedi-179	151	11	.	.	PUNCT
clinmedi-179	151	12	robidoux	robidoux	VERB
clinmedi-179	151	13	a	a	PRON
clinmedi-179	151	14	,	,	PUNCT
clinmedi-179	151	15	buzdar	buzdar	NOUN
clinmedi-179	151	16	au	au	PROPN
clinmedi-179	151	17	,	,	PUNCT
clinmedi-179	151	18	quinaux	quinaux	VERB
clinmedi-179	151	19	e	e	PROPN
clinmedi-179	151	20	et	et	PROPN
clinmedi-179	151	21	al	al	PROPN
clinmedi-179	151	22	.	.	PUNCT
clinmedi-179	152	1	a	a	DET
clinmedi-179	152	2	phase	phase	NOUN
clinmedi-179	152	3	ii	ii	PROPN
clinmedi-179	152	4	neoadjuvant	neoadjuvant	ADJ
clinmedi-179	152	5	trial	trial	NOUN
clinmedi-179	152	6	of	of	ADP
clinmedi-179	152	7	sequential	sequential	ADJ
clinmedi-179	152	8	nanoparticle	nanoparticle	NOUN
clinmedi-179	152	9	albumin	albumin	NOUN
clinmedi-179	152	10	-	-	PUNCT
clinmedi-179	152	11	bound	bind	VERB
clinmedi-179	152	12	paclitaxel	paclitaxel	NOUN
clinmedi-179	152	13	followed	follow	VERB
clinmedi-179	152	14	by	by	ADP
clinmedi-179	152	15	5	5	NUM
clinmedi-179	152	16	-	-	PUNCT
clinmedi-179	152	17	fluorouracil	fluorouracil	NOUN
clinmedi-179	152	18	/	/	SYM
clinmedi-179	152	19	epirubicin/	epirubicin/	NUM
clinmedi-179	152	20	cyclophosphamide	cyclophosphamide	NOUN
clinmedi-179	152	21	in	in	ADP
clinmedi-179	152	22	locally	locally	ADV
clinmedi-179	152	23	advanced	advanced	ADJ
clinmedi-179	152	24	breast	breast	NOUN
clinmedi-179	152	25	cancer	cancer	NOUN
clinmedi-179	152	26	.	.	PUNCT
clinmedi-179	153	1	clin	clin	PROPN
clinmedi-179	153	2	breast	breast	PROPN
clinmedi-179	153	3	cancer	cancer	NOUN
clinmedi-179	153	4	2010	2010	NUM
clinmedi-179	153	5	;	;	PUNCT
clinmedi-179	153	6	10	10	NUM
clinmedi-179	153	7	:	:	PUNCT
clinmedi-179	153	8	81–6	81–6	NUM
clinmedi-179	153	9	.	.	PROPN
clinmedi-179	153	10	12	12	NUM
clinmedi-179	153	11	.	.	PUNCT
clinmedi-179	154	1	futamura	futamura	PROPN
clinmedi-179	154	2	m	m	PROPN
clinmedi-179	154	3	,	,	PUNCT
clinmedi-179	154	4	nagao	nagao	ADJ
clinmedi-179	154	5	y	y	PROPN
clinmedi-179	154	6	,	,	PUNCT
clinmedi-179	154	7	ishihara	ishihara	PROPN
clinmedi-179	155	1	k	k	PROPN
clinmedi-179	155	2	et	et	PROPN
clinmedi-179	155	3	al	al	PROPN
clinmedi-179	155	4	.	.	PROPN
clinmedi-179	155	5	preoperative	preoperative	ADJ
clinmedi-179	155	6	neoadjuvant	neoadjuvant	ADJ
clinmedi-179	155	7	chemotherapy	chemotherapy	NOUN
clinmedi-179	155	8	using	use	VERB
clinmedi-179	155	9	nanoparticle	nanoparticle	NOUN
clinmedi-179	155	10	albumin	albumin	NOUN
clinmedi-179	155	11	-	-	PUNCT
clinmedi-179	155	12	bound	bind	VERB
clinmedi-179	155	13	paclitaxel	paclitaxel	NOUN
clinmedi-179	155	14	followed	follow	VERB
clinmedi-179	155	15	by	by	ADP
clinmedi-179	155	16	epirubicin	epirubicin	NOUN
clinmedi-179	155	17	and	and	CCONJ
clinmedi-179	155	18	cyclophosphamide	cyclophosphamide	VERB
clinmedi-179	155	19	for	for	ADP
clinmedi-179	155	20	operable	operable	ADJ
clinmedi-179	155	21	breast	breast	NOUN
clinmedi-179	155	22	cancer	cancer	NOUN
clinmedi-179	155	23	:	:	PUNCT
clinmedi-179	155	24	a	a	DET
clinmedi-179	155	25	multicenter	multicenter	ADJ
clinmedi-179	155	26	phase	phase	NOUN
clinmedi-179	155	27	ii	ii	NOUN
clinmedi-179	155	28	trial	trial	NOUN
clinmedi-179	155	29	.	.	PUNCT
clinmedi-179	156	1	breast	breast	NOUN
clinmedi-179	156	2	cancer	cancer	NOUN
clinmedi-179	156	3	2017	2017	NUM
clinmedi-179	156	4	;	;	PUNCT
clinmedi-179	156	5	24	24	NUM
clinmedi-179	156	6	:	:	PUNCT
clinmedi-179	156	7	615–23	615–23	PROPN
clinmedi-179	156	8	.	.	PROPN
clinmedi-179	157	1	13	13	NUM
clinmedi-179	157	2	.	.	PUNCT
clinmedi-179	157	3	kuwayama	kuwayama	PROPN
clinmedi-179	157	4	t	t	PROPN
clinmedi-179	157	5	,	,	PUNCT
clinmedi-179	157	6	nakamura	nakamura	NOUN
clinmedi-179	157	7	s	s	PROPN
clinmedi-179	157	8	,	,	PUNCT
clinmedi-179	157	9	hayashi	hayashi	PROPN
clinmedi-179	157	10	n	n	PROPN
clinmedi-179	157	11	et	et	PROPN
clinmedi-179	157	12	al	al	PROPN
clinmedi-179	157	13	.	.	PROPN
clinmedi-179	157	14	randomized	randomize	VERB
clinmedi-179	157	15	multicenter	multicenter	NOUN
clinmedi-179	157	16	phase	phase	NOUN
clinmedi-179	157	17	ii	ii	NOUN
clinmedi-179	157	18	trial	trial	NOUN
clinmedi-179	157	19	of	of	ADP
clinmedi-179	157	20	neoadjuvant	neoadjuvant	ADJ
clinmedi-179	157	21	therapy	therapy	NOUN
clinmedi-179	157	22	comparing	compare	VERB
clinmedi-179	157	23	weekly	weekly	ADJ
clinmedi-179	157	24	nabpaclitaxel	nabpaclitaxel	NOUN
clinmedi-179	157	25	followed	follow	VERB
clinmedi-179	157	26	by	by	ADP
clinmedi-179	157	27	fec	fec	PROPN
clinmedi-179	157	28	with	with	ADP
clinmedi-179	157	29	docetaxel	docetaxel	NOUN
clinmedi-179	157	30	followed	follow	VERB
clinmedi-179	157	31	by	by	ADP
clinmedi-179	157	32	fec	fec	PROPN
clinmedi-179	157	33	in	in	ADP
clinmedi-179	157	34	her2early	her2early	ADJ
clinmedi-179	157	35	-	-	PUNCT
clinmedi-179	157	36	stage	stage	NOUN
clinmedi-179	157	37	breast	breast	NOUN
clinmedi-179	157	38	cancer	cancer	NOUN
clinmedi-179	157	39	.	.	PUNCT
clinmedi-179	158	1	clin	clin	PROPN
clinmedi-179	158	2	breast	breast	PROPN
clinmedi-179	158	3	cancer	cancer	PROPN
clinmedi-179	158	4	2018	2018	NUM
clinmedi-179	158	5	;	;	PUNCT
clinmedi-179	158	6	18	18	NUM
clinmedi-179	158	7	:	:	PUNCT
clinmedi-179	158	8	474–80	474–80	PROPN
clinmedi-179	158	9	.	.	PUNCT
clinmedi-179	159	1	14	14	NUM
clinmedi-179	159	2	.	.	PUNCT
clinmedi-179	160	1	untch	untch	PROPN
clinmedi-179	160	2	m	m	PROPN
clinmedi-179	160	3	,	,	PUNCT
clinmedi-179	160	4	jackisch	jackisch	ADV
clinmedi-179	160	5	c	c	NOUN
clinmedi-179	160	6	,	,	PUNCT
clinmedi-179	160	7	schneeweiss	schneeweis	VERB
clinmedi-179	160	8	a	a	PRON
clinmedi-179	160	9	et	et	NOUN
clinmedi-179	160	10	al	al	PROPN
clinmedi-179	160	11	.	.	PUNCT
clinmedi-179	161	1	nab	nab	PROPN
clinmedi-179	161	2	-	-	PUNCT
clinmedi-179	161	3	paclitaxel	paclitaxel	NOUN
clinmedi-179	161	4	versus	versus	ADP
clinmedi-179	161	5	solvent	solvent	NOUN
clinmedi-179	161	6	-	-	PUNCT
clinmedi-179	161	7	based	base	VERB
clinmedi-179	161	8	paclitaxel	paclitaxel	PROPN
clinmedi-179	161	9	in	in	ADP
clinmedi-179	161	10	neoadjuvant	neoadjuvant	ADJ
clinmedi-179	161	11	chemotherapy	chemotherapy	NOUN
clinmedi-179	161	12	for	for	ADP
clinmedi-179	161	13	early	early	ADJ
clinmedi-179	161	14	breast	breast	NOUN
clinmedi-179	161	15	cancer	cancer	NOUN
clinmedi-179	161	16	(	(	PUNCT
clinmedi-179	161	17	geparsepto	geparsepto	INTJ
clinmedi-179	161	18	—	—	PUNCT
clinmedi-179	161	19	gbg	gbg	PROPN
clinmedi-179	161	20	69	69	NUM
clinmedi-179	161	21	):	):	PUNCT
clinmedi-179	161	22	a	a	DET
clinmedi-179	161	23	randomised	randomised	ADJ
clinmedi-179	161	24	,	,	PUNCT
clinmedi-179	161	25	phase	phase	NOUN
clinmedi-179	161	26	3	3	NUM
clinmedi-179	161	27	trial	trial	NOUN
clinmedi-179	161	28	.	.	PUNCT
clinmedi-179	162	1	lancet	lancet	PROPN
clinmedi-179	162	2	oncol	oncol	ADJ
clinmedi-179	162	3	2016	2016	NUM
clinmedi-179	162	4	;	;	PUNCT
clinmedi-179	162	5	17	17	NUM
clinmedi-179	162	6	:	:	PUNCT
clinmedi-179	162	7	345–56	345–56	NUM
clinmedi-179	162	8	.	.	X
clinmedi-179	163	1	15	15	NUM
clinmedi-179	163	2	.	.	X
clinmedi-179	163	3	futamura	futamura	NOUN
clinmedi-179	163	4	m	m	PROPN
clinmedi-179	163	5	,	,	PUNCT
clinmedi-179	163	6	oba	oba	PROPN
clinmedi-179	163	7	m	m	PROPN
clinmedi-179	163	8	,	,	PUNCT
clinmedi-179	163	9	masuda	masuda	PROPN
clinmedi-179	163	10	n	n	PROPN
clinmedi-179	163	11	et	et	PROPN
clinmedi-179	163	12	al	al	PROPN
clinmedi-179	163	13	.	.	PUNCT
clinmedi-179	164	1	meta‑analysis	meta‑analysi	NOUN
clinmedi-179	164	2	of	of	ADP
clinmedi-179	164	3	nanoparticle	nanoparticle	NOUN
clinmedi-179	164	4	albumin‑bound	albumin‑bound	PROPN
clinmedi-179	164	5	paclitaxel	paclitaxel	PROPN
clinmedi-179	164	6	used	use	VERB
clinmedi-179	164	7	as	as	ADP
clinmedi-179	164	8	neoadjuvant	neoadjuvant	ADJ
clinmedi-179	164	9	chemotherapy	chemotherapy	NOUN
clinmedi-179	164	10	for	for	ADP
clinmedi-179	164	11	operable	operable	ADJ
clinmedi-179	164	12	breast	breast	NOUN
clinmedi-179	164	13	cancer	cancer	NOUN
clinmedi-179	164	14	based	base	VERB
clinmedi-179	164	15	on	on	ADP
clinmedi-179	164	16	individual	individual	ADJ
clinmedi-179	164	17	patient	patient	ADJ
clinmedi-179	164	18	data	datum	NOUN
clinmedi-179	164	19	(	(	PUNCT
clinmedi-179	164	20	jbcrg‑s01	jbcrg‑s01	PROPN
clinmedi-179	164	21	study	study	PROPN
clinmedi-179	164	22	)	)	PUNCT
clinmedi-179	164	23	.	.	PUNCT
clinmedi-179	165	1	breast	breast	NOUN
clinmedi-179	165	2	cancer	cancer	NOUN
clinmedi-179	165	3	2021	2021	NUM
clinmedi-179	165	4	;	;	PUNCT
clinmedi-179	165	5	28	28	NUM
clinmedi-179	165	6	:	:	PUNCT
clinmedi-179	165	7	1023–37	1023–37	NOUN
clinmedi-179	165	8	.	.	PUNCT
clinmedi-179	166	1	16	16	NUM
clinmedi-179	166	2	.	.	PUNCT
clinmedi-179	167	1	tanaka	tanaka	PROPN
clinmedi-179	167	2	s	s	PROPN
clinmedi-179	167	3	,	,	PUNCT
clinmedi-179	167	4	iwamoto	iwamoto	PROPN
clinmedi-179	167	5	m	m	NOUN
clinmedi-179	167	6	,	,	PUNCT
clinmedi-179	167	7	kimura	kimura	NOUN
clinmedi-179	167	8	k	k	PROPN
clinmedi-179	167	9	et	et	PROPN
clinmedi-179	167	10	al	al	PROPN
clinmedi-179	167	11	.	.	PROPN
clinmedi-179	167	12	phase	phase	PROPN
clinmedi-179	167	13	ii	ii	PROPN
clinmedi-179	167	14	study	study	NOUN
clinmedi-179	167	15	of	of	ADP
clinmedi-179	167	16	neoadjuvant	neoadjuvant	ADJ
clinmedi-179	167	17	anthracycline	anthracycline	NOUN
clinmedi-179	167	18	-	-	PUNCT
clinmedi-179	167	19	based	base	VERB
clinmedi-179	167	20	regimens	regimen	NOUN
clinmedi-179	167	21	combined	combine	VERB
clinmedi-179	167	22	with	with	ADP
clinmedi-179	167	23	nanoparticle	nanoparticle	NOUN
clinmedi-179	167	24	albumin	albumin	NOUN
clinmedi-179	167	25	-	-	PUNCT
clinmedi-179	167	26	bound	bind	VERB
clinmedi-179	167	27	paclitaxel	paclitaxel	NOUN
clinmedi-179	167	28	and	and	CCONJ
clinmedi-179	167	29	trastuzumab	trastuzumab	NOUN
clinmedi-179	167	30	for	for	ADP
clinmedi-179	167	31	human	human	ADJ
clinmedi-179	167	32	epidermal	epidermal	ADJ
clinmedi-179	167	33	growth	growth	NOUN
clinmedi-179	167	34	factor	factor	NOUN
clinmedi-179	167	35	receptor	receptor	NOUN
clinmedi-179	167	36	2positive	2positive	NUM
clinmedi-179	167	37	operable	operable	ADJ
clinmedi-179	167	38	breast	breast	NOUN
clinmedi-179	167	39	cancer	cancer	NOUN
clinmedi-179	167	40	.	.	PUNCT
clinmedi-179	168	1	clin	clin	PROPN
clinmedi-179	168	2	breast	breast	PROPN
clinmedi-179	168	3	cancer	cancer	PROPN
clinmedi-179	168	4	2015	2015	NUM
clinmedi-179	168	5	;	;	PUNCT
clinmedi-179	168	6	15	15	NUM
clinmedi-179	168	7	:	:	SYM
clinmedi-179	168	8	191–6	191–6	NUM
clinmedi-179	168	9	.	.	NOUN
clinmedi-179	168	10	17	17	NUM
clinmedi-179	168	11	.	.	PUNCT
clinmedi-179	169	1	untch	untch	PROPN
clinmedi-179	169	2	m	m	PROPN
clinmedi-179	169	3	,	,	PUNCT
clinmedi-179	169	4	jackisch	jackisch	ADV
clinmedi-179	169	5	c	c	NOUN
clinmedi-179	169	6	,	,	PUNCT
clinmedi-179	169	7	schneeweiss	schneeweis	VERB
clinmedi-179	169	8	a	a	DET
clinmedi-179	169	9	et	et	NOUN
clinmedi-179	169	10	al	al	PROPN
clinmedi-179	169	11	.	.	PUNCT
clinmedi-179	170	1	nab	nab	PROPN
clinmedi-179	170	2	-	-	PUNCT
clinmedi-179	170	3	paclitaxel	paclitaxel	PROPN
clinmedi-179	170	4	improves	improve	VERB
clinmedi-179	170	5	disease	disease	NOUN
clinmedi-179	170	6	-	-	PUNCT
clinmedi-179	170	7	free	free	ADJ
clinmedi-179	170	8	survival	survival	NOUN
clinmedi-179	170	9	in	in	ADP
clinmedi-179	170	10	early	early	ADJ
clinmedi-179	170	11	breast	breast	NOUN
clinmedi-179	170	12	cancer	cancer	NOUN
clinmedi-179	170	13	:	:	PUNCT
clinmedi-179	170	14	gbg	gbg	PROPN
clinmedi-179	170	15	69	69	NUM
clinmedi-179	170	16	-	-	PUNCT
clinmedi-179	170	17	geparsepto	geparsepto	NOUN
clinmedi-179	170	18	.	.	PUNCT
clinmedi-179	171	1	j	j	PROPN
clinmedi-179	171	2	clin	clin	PROPN
clinmedi-179	171	3	oncol	oncol	PROPN
clinmedi-179	171	4	2019	2019	NUM
clinmedi-179	171	5	;	;	PUNCT
clinmedi-179	171	6	37	37	NUM
clinmedi-179	171	7	:	:	PUNCT
clinmedi-179	171	8	2226–34	2226–34	NUM
clinmedi-179	171	9	.	.	PUNCT
clinmedi-179	172	1	18	18	NUM
clinmedi-179	172	2	.	.	PUNCT
clinmedi-179	172	3	von	von	PROPN
clinmedi-179	172	4	minckwitz	minckwitz	PROPN
clinmedi-179	172	5	g	g	PROPN
clinmedi-179	172	6	,	,	PUNCT
clinmedi-179	172	7	procter	procter	PROPN
clinmedi-179	172	8	m	m	PROPN
clinmedi-179	172	9	,	,	PUNCT
clinmedi-179	172	10	de	de	X
clinmedi-179	172	11	azambuja	azambuja	NOUN
clinmedi-179	172	12	e	e	X
clinmedi-179	172	13	et	et	PROPN
clinmedi-179	172	14	al	al	PROPN
clinmedi-179	172	15	.	.	PROPN
clinmedi-179	173	1	adjuvant	adjuvant	PROPN
clinmedi-179	173	2	pertuzumab	pertuzumab	NOUN
clinmedi-179	173	3	and	and	CCONJ
clinmedi-179	173	4	trastuzumab	trastuzumab	NOUN
clinmedi-179	173	5	in	in	ADP
clinmedi-179	173	6	early	early	ADJ
clinmedi-179	173	7	her2	her2	PROPN
clinmedi-179	173	8	-	-	PUNCT
clinmedi-179	173	9	positive	positive	ADJ
clinmedi-179	173	10	breast	breast	NOUN
clinmedi-179	173	11	cancer	cancer	NOUN
clinmedi-179	173	12	.	.	PUNCT
clinmedi-179	174	1	n	n	PROPN
clinmedi-179	174	2	engl	engl	PROPN
clinmedi-179	174	3	j	j	PROPN
clinmedi-179	174	4	med	med	PROPN
clinmedi-179	174	5	2017	2017	NUM
clinmedi-179	174	6	;	;	PUNCT
clinmedi-179	174	7	377	377	NUM
clinmedi-179	174	8	:	:	PUNCT
clinmedi-179	174	9	122–31	122–31	NUM
clinmedi-179	174	10	.	.	NOUN
clinmedi-179	174	11	19	19	NUM
clinmedi-179	174	12	.	.	NUM
clinmedi-179	174	13	lambertinim	lambertinim	PROPN
clinmedi-179	174	14	,	,	PUNCT
clinmedi-179	174	15	poggio	poggio	PROPN
clinmedi-179	174	16	f	f	PROPN
clinmedi-179	174	17	,	,	PUNCT
clinmedi-179	174	18	bruzzone	bruzzone	NOUN
clinmedi-179	174	19	m	m	PROPN
clinmedi-179	174	20	,	,	PUNCT
clinmedi-179	174	21	et	et	PROPN
clinmedi-179	174	22	al	al	PROPN
clinmedi-179	174	23	.	.	PROPN
clinmedi-179	174	24	dose	dose	NOUN
clinmedi-179	174	25	-	-	PUNCT
clinmedi-179	174	26	dense	dense	ADJ
clinmedi-179	174	27	adjuvant	adjuvant	ADJ
clinmedi-179	174	28	chemotherapy	chemotherapy	NOUN
clinmedi-179	174	29	in	in	ADP
clinmedi-179	174	30	her2positive	her2positive	PROPN
clinmedi-179	174	31	earlybreast	earlybreast	NOUN
clinmedi-179	174	32	cancer	cancer	NOUN
clinmedi-179	174	33	patients	patient	NOUN
clinmedi-179	174	34	before	before	ADP
clinmedi-179	174	35	and	and	CCONJ
clinmedi-179	174	36	after	after	ADP
clinmedi-179	174	37	the	the	DET
clinmedi-179	174	38	introduction	introduction	NOUN
clinmedi-179	174	39	of	of	ADP
clinmedi-179	174	40	trastuzumab	trastuzumab	NOUN
clinmedi-179	174	41	:	:	PUNCT
clinmedi-179	174	42	exploratory	exploratory	ADJ
clinmedi-179	174	43	analysis	analysis	NOUN
clinmedi-179	174	44	of	of	ADP
clinmedi-179	174	45	the	the	DET
clinmedi-179	174	46	gim2	gim2	NOUN
clinmedi-179	174	47	trial	trial	NOUN
clinmedi-179	174	48	.	.	PUNCT
clinmedi-179	175	1	int	int	NOUN
clinmedi-179	175	2	.	.	PUNCT
clinmedi-179	176	1	j.	j.	PROPN
clinmedi-179	176	2	cancer	cancer	PROPN
clinmedi-179	176	3	202;147,160–169	202;147,160–169	PROPN
clinmedi-179	176	4	.	.	PUNCT
clinmedi-179	177	1	20	20	NUM
clinmedi-179	177	2	.	.	PUNCT
clinmedi-179	178	1	holmes	holmes	PROPN
clinmedi-179	178	2	fa	fa	PROPN
clinmedi-179	178	3	,	,	PUNCT
clinmedi-179	178	4	hellerstedt	hellerstedt	PROPN
clinmedi-179	178	5	ba	ba	PROPN
clinmedi-179	178	6	,	,	PUNCT
clinmedi-179	178	7	pippen	pippen	PROPN
clinmedi-179	178	8	j	j	PROPN
clinmedi-179	178	9	et	et	PROPN
clinmedi-179	178	10	al	al	PROPN
clinmedi-179	178	11	.	.	PROPN
clinmedi-179	179	1	five	five	NUM
clinmedi-179	179	2	-	-	PUNCT
clinmedi-179	179	3	year	year	NOUN
clinmedi-179	179	4	results	result	NOUN
clinmedi-179	179	5	of	of	ADP
clinmedi-179	179	6	a	a	DET
clinmedi-179	179	7	phase	phase	NOUN
clinmedi-179	179	8	ii	ii	NOUN
clinmedi-179	179	9	trial	trial	NOUN
clinmedi-179	179	10	of	of	ADP
clinmedi-179	179	11	preoperative	preoperative	ADJ
clinmedi-179	179	12	5	5	NUM
clinmedi-179	179	13	-	-	PUNCT
clinmedi-179	179	14	fluorouracil	fluorouracil	NOUN
clinmedi-179	179	15	,	,	PUNCT
clinmedi-179	179	16	epirubicin	epirubicin	PRON
clinmedi-179	179	17	,	,	PUNCT
clinmedi-179	179	18	cyclophosphamide	cyclophosphamide	PROPN
clinmedi-179	179	19	followed	follow	VERB
clinmedi-179	179	20	by	by	ADP
clinmedi-179	179	21	docetaxel	docetaxel	NOUN
clinmedi-179	179	22	with	with	ADP
clinmedi-179	179	23	cmi	cmi	PROPN
clinmedi-179	179	24	04	04	NUM
clinmedi-179	179	25	(	(	PUNCT
clinmedi-179	179	26	02	02	NUM
clinmedi-179	179	27	)	)	PUNCT
clinmedi-179	179	28	,	,	PUNCT
clinmedi-179	179	29	378−386	378−386	NUM
clinmedi-179	179	30	cmi	cmi	PROPN
clinmedi-179	179	31	journal	journal	NOUN
clinmedi-179	179	32	386	386	NUM
clinmedi-179	179	33	cmi	cmi	PROPN
clinmedi-179	179	34	journal	journal	PROPN
clinmedi-179	179	35	kazumi	kazumi	PROPN
clinmedi-179	179	36	kawase	kawase	PROPN
clinmedi-179	179	37	et	et	PROPN
clinmedi-179	179	38	al	al	PROPN
clinmedi-179	179	39	.	.	PROPN
clinmedi-179	179	40	capecitabine	capecitabine	PROPN
clinmedi-179	179	41	(	(	PUNCT
clinmedi-179	179	42	wtx)(with	wtx)(with	ADP
clinmedi-179	179	43	trastuzumab	trastuzumab	NOUN
clinmedi-179	179	44	in	in	ADP
clinmedi-179	179	45	her2	her2	PROPN
clinmedi-179	179	46	-	-	PUNCT
clinmedi-179	179	47	positive	positive	ADJ
clinmedi-179	179	48	patients	patient	NOUN
clinmedi-179	179	49	)	)	PUNCT
clinmedi-179	179	50	for	for	ADP
clinmedi-179	179	51	patients	patient	NOUN
clinmedi-179	179	52	with	with	ADP
clinmedi-179	179	53	stage	stage	NOUN
clinmedi-179	179	54	ii	ii	PROPN
clinmedi-179	179	55	or	or	CCONJ
clinmedi-179	179	56	iii	iii	NUM
clinmedi-179	179	57	breast	breast	NOUN
clinmedi-179	179	58	cancer	cancer	NOUN
clinmedi-179	179	59	.	.	PUNCT
clinmedi-179	180	1	cancer	cancer	NOUN
clinmedi-179	180	2	med	med	PROPN
clinmedi-179	180	3	2018	2018	NUM
clinmedi-179	180	4	;	;	PUNCT
clinmedi-179	181	1	7	7	NUM
clinmedi-179	181	2	:	:	PUNCT
clinmedi-179	181	3	2288–98	2288–98	NUM
clinmedi-179	181	4	.	.	PUNCT
clinmedi-179	182	1	21	21	NUM
clinmedi-179	182	2	.	.	PUNCT
clinmedi-179	183	1	tanaka	tanaka	PROPN
clinmedi-179	183	2	s	s	PROPN
clinmedi-179	183	3	,	,	PUNCT
clinmedi-179	183	4	matsunami	matsunami	NOUN
clinmedi-179	183	5	n	n	CCONJ
clinmedi-179	183	6	,	,	PUNCT
clinmedi-179	183	7	morishima	morishima	PROPN
clinmedi-179	183	8	h	h	PROPN
clinmedi-179	183	9	et	et	PROPN
clinmedi-179	183	10	al	al	PROPN
clinmedi-179	183	11	.	.	PUNCT
clinmedi-179	183	12	de‑escalated	de‑escalate	VERB
clinmedi-179	183	13	neoadjuvant	neoadjuvant	ADJ
clinmedi-179	183	14	therapy	therapy	NOUN
clinmedi-179	183	15	with	with	ADP
clinmedi-179	183	16	nanoparticle	nanoparticle	PROPN
clinmedi-179	183	17	albumin‑bound	albumin‑bound	PROPN
clinmedi-179	183	18	paclitaxel	paclitaxel	PROPN
clinmedi-179	183	19	and	and	CCONJ
clinmedi-179	183	20	trastuzumab	trastuzumab	NOUN
clinmedi-179	183	21	for	for	ADP
clinmedi-179	183	22	low‑risk	low‑risk	ADJ
clinmedi-179	183	23	pure	pure	ADJ
clinmedi-179	183	24	her2	her2	PROPN
clinmedi-179	183	25	breast	breast	NOUN
clinmedi-179	183	26	cancer	cancer	NOUN
clinmedi-179	183	27	.	.	PUNCT
clinmedi-179	184	1	cancer	cancer	NOUN
clinmedi-179	184	2	chemother	chemother	PROPN
clinmedi-179	184	3	pharmacol	pharmacol	PROPN
clinmedi-179	184	4	2019	2019	NUM
clinmedi-179	184	5	;	;	PUNCT
clinmedi-179	184	6	83	83	NUM
clinmedi-179	184	7	:	:	SYM
clinmedi-179	184	8	1099–104	1099–104	PROPN
clinmedi-179	184	9	.	.	PUNCT
clinmedi-179	185	1	22	22	NUM
clinmedi-179	185	2	.	.	PUNCT
clinmedi-179	186	1	nakamura	nakamura	PROPN
clinmedi-179	186	2	s	s	PROPN
clinmedi-179	186	3	,	,	PUNCT
clinmedi-179	186	4	iwata	iwata	PROPN
clinmedi-179	186	5	h	h	PROPN
clinmedi-179	186	6	,	,	PUNCT
clinmedi-179	186	7	funano	funano	PROPN
clinmedi-179	186	8	y	y	PROPN
clinmedi-179	186	9	,	,	PUNCT
clinmedi-179	186	10	ito	ito	PROPN
clinmedi-179	186	11	k	k	PROPN
clinmedi-179	186	12	,	,	PUNCT
clinmedi-179	186	13	ito	ito	PROPN
clinmedi-179	186	14	y.	y.	PROPN
clinmedi-179	186	15	results	result	NOUN
clinmedi-179	186	16	of	of	ADP
clinmedi-179	186	17	a	a	DET
clinmedi-179	186	18	drug	drug	NOUN
clinmedi-179	186	19	use	use	NOUN
clinmedi-179	186	20	investigation	investigation	NOUN
clinmedi-179	186	21	of	of	ADP
clinmedi-179	186	22	nanoparticle	nanoparticle	NOUN
clinmedi-179	186	23	albumin	albumin	NOUN
clinmedi-179	186	24	-	-	PUNCT
clinmedi-179	186	25	bound	bind	VERB
clinmedi-179	186	26	paclitaxel	paclitaxel	NOUN
clinmedi-179	186	27	for	for	ADP
clinmedi-179	186	28	breast	breast	NOUN
clinmedi-179	186	29	cancer	cancer	NOUN
clinmedi-179	186	30	.	.	PUNCT
clinmedi-179	187	1	gan	gin	VERB
clinmedi-179	187	2	to	to	ADP
clinmedi-179	187	3	kagaku	kagaku	PROPN
clinmedi-179	187	4	ryoho	ryoho	PROPN
clinmedi-179	187	5	2015	2015	NUM
clinmedi-179	187	6	;	;	PUNCT
clinmedi-179	187	7	42	42	NUM
clinmedi-179	187	8	:	:	PUNCT
clinmedi-179	187	9	447–55	447–55	PROPN
clinmedi-179	187	10	(	(	PUNCT
clinmedi-179	187	11	in	in	ADP
clinmedi-179	187	12	japanese	japanese	PROPN
clinmedi-179	187	13	)	)	PUNCT
clinmedi-179	187	14	.	.	PUNCT
clinmedi-179	188	1	23	23	NUM
clinmedi-179	188	2	.	.	X
clinmedi-179	189	1	rugo	rugo	PROPN
clinmedi-179	189	2	hs	hs	PROPN
clinmedi-179	189	3	,	,	PUNCT
clinmedi-179	189	4	barry	barry	PROPN
clinmedi-179	189	5	wt	wt	PROPN
clinmedi-179	189	6	,	,	PUNCT
clinmedi-179	189	7	moreno	moreno	PROPN
clinmedi-179	189	8	-	-	PUNCT
clinmedi-179	189	9	aspitia	aspitia	PROPN
clinmedi-179	189	10	a	a	DET
clinmedi-179	189	11	et	et	NOUN
clinmedi-179	189	12	al	al	PROPN
clinmedi-179	189	13	.	.	PROPN
clinmedi-179	189	14	randomized	randomize	VERB
clinmedi-179	189	15	phase	phase	NOUN
clinmedi-179	189	16	iii	iii	NOUN
clinmedi-179	189	17	trial	trial	NOUN
clinmedi-179	189	18	of	of	ADP
clinmedi-179	189	19	paclitaxel	paclitaxel	PROPN
clinmedi-179	189	20	once	once	ADV
clinmedi-179	189	21	per	per	ADP
clinmedi-179	189	22	week	week	NOUN
clinmedi-179	189	23	compared	compare	VERB
clinmedi-179	189	24	with	with	ADP
clinmedi-179	189	25	nanoparticle	nanoparticle	NOUN
clinmedi-179	189	26	albumin	albumin	NOUN
clinmedi-179	189	27	-	-	PUNCT
clinmedi-179	189	28	bound	bind	VERB
clinmedi-179	189	29	nab	nab	NOUN
clinmedi-179	189	30	-	-	PUNCT
clinmedi-179	189	31	paclitaxel	paclitaxel	PROPN
clinmedi-179	189	32	once	once	ADV
clinmedi-179	189	33	per	per	ADP
clinmedi-179	189	34	week	week	NOUN
clinmedi-179	189	35	or	or	CCONJ
clinmedi-179	189	36	ixabepilone	ixabepilone	NOUN
clinmedi-179	189	37	with	with	ADP
clinmedi-179	189	38	bevacizumab	bevacizumab	NOUN
clinmedi-179	189	39	as	as	ADP
clinmedi-179	189	40	first	first	ADJ
clinmedi-179	189	41	-	-	PUNCT
clinmedi-179	189	42	line	line	NOUN
clinmedi-179	189	43	chemotherapy	chemotherapy	NOUN
clinmedi-179	189	44	for	for	ADP
clinmedi-179	189	45	locally	locally	ADV
clinmedi-179	189	46	recurrent	recurrent	ADJ
clinmedi-179	189	47	or	or	CCONJ
clinmedi-179	189	48	metastatic	metastatic	ADJ
clinmedi-179	189	49	breast	breast	NOUN
clinmedi-179	189	50	cancer	cancer	NOUN
clinmedi-179	189	51	:	:	PUNCT
clinmedi-179	189	52	calgb	calgb	PROPN
clinmedi-179	189	53	40502	40502	NUM
clinmedi-179	189	54	/	/	SYM
clinmedi-179	190	1	ncctg	ncctg	VERB
clinmedi-179	190	2	n063h	n063h	PROPN
clinmedi-179	190	3	(	(	PUNCT
clinmedi-179	190	4	alliance	alliance	NOUN
clinmedi-179	190	5	)	)	PUNCT
clinmedi-179	190	6	.	.	PUNCT
clinmedi-179	191	1	j	j	PROPN
clinmedi-179	191	2	clin	clin	PROPN
clinmedi-179	191	3	oncol	oncol	PROPN
clinmedi-179	191	4	2015	2015	NUM
clinmedi-179	191	5	;	;	PUNCT
clinmedi-179	191	6	33	33	NUM
clinmedi-179	191	7	:	:	SYM
clinmedi-179	191	8	2361–9	2361–9	NUM
clinmedi-179	191	9	.	.	NOUN
clinmedi-179	191	10	24	24	NUM
clinmedi-179	191	11	.	.	PUNCT
clinmedi-179	192	1	schmid	schmid	PROPN
clinmedi-179	192	2	p	p	PROPN
clinmedi-179	192	3	,	,	PUNCT
clinmedi-179	192	4	adams	adams	PROPN
clinmedi-179	192	5	s	s	PROPN
clinmedi-179	192	6	,	,	PUNCT
clinmedi-179	192	7	rugo	rugo	PROPN
clinmedi-179	192	8	hs	hs	PROPN
clinmedi-179	192	9	et	et	PROPN
clinmedi-179	192	10	al	al	PROPN
clinmedi-179	192	11	.	.	PROPN
clinmedi-179	192	12	atezolizumab	atezolizumab	PROPN
clinmedi-179	192	13	and	and	CCONJ
clinmedi-179	192	14	nab	nab	NOUN
clinmedi-179	192	15	-	-	PUNCT
clinmedi-179	192	16	paclitaxel	paclitaxel	PROPN
clinmedi-179	192	17	in	in	ADP
clinmedi-179	192	18	advanced	advanced	ADJ
clinmedi-179	192	19	triple	triple	ADJ
clinmedi-179	192	20	-	-	PUNCT
clinmedi-179	192	21	negative	negative	ADJ
clinmedi-179	192	22	breast	breast	NOUN
clinmedi-179	192	23	cancer	cancer	NOUN
clinmedi-179	192	24	.	.	PUNCT
clinmedi-179	193	1	n	n	PROPN
clinmedi-179	193	2	engl	engl	PROPN
clinmedi-179	193	3	j	j	PROPN
clinmedi-179	193	4	med	med	PROPN
clinmedi-179	193	5	2018	2018	NUM
clinmedi-179	193	6	;	;	PUNCT
clinmedi-179	193	7	379	379	NUM
clinmedi-179	193	8	:	:	PUNCT
clinmedi-179	193	9	2108–21	2108–21	NUM
clinmedi-179	193	10	.	.	PUNCT
clinmedi-179	194	1	25	25	NUM
clinmedi-179	194	2	.	.	PUNCT
clinmedi-179	194	3	tsurutani	tsurutani	PROPN
clinmedi-179	194	4	j	j	PROPN
clinmedi-179	194	5	,	,	PUNCT
clinmedi-179	194	6	hara	hara	PROPN
clinmedi-179	194	7	f	f	PROPN
clinmedi-179	194	8	,	,	PUNCT
clinmedi-179	194	9	kitada	kitada	PROPN
clinmedi-179	194	10	m	m	VERB
clinmedi-179	194	11	et	et	PROPN
clinmedi-179	194	12	al	al	PROPN
clinmedi-179	194	13	.	.	PROPN
clinmedi-179	194	14	randomized	randomize	VERB
clinmedi-179	194	15	phase	phase	NOUN
clinmedi-179	194	16	ii	ii	PROPN
clinmedi-179	194	17	study	study	NOUN
clinmedi-179	194	18	to	to	PART
clinmedi-179	194	19	determine	determine	VERB
clinmedi-179	194	20	the	the	DET
clinmedi-179	194	21	optimal	optimal	ADJ
clinmedi-179	194	22	dose	dose	NOUN
clinmedi-179	194	23	of	of	ADP
clinmedi-179	194	24	3	3	NUM
clinmedi-179	194	25	-	-	PUNCT
clinmedi-179	194	26	week	week	NOUN
clinmedi-179	194	27	cycle	cycle	NOUN
clinmedi-179	194	28	nab	nab	NOUN
clinmedi-179	194	29	-	-	PUNCT
clinmedi-179	194	30	paclitaxel	paclitaxel	ADJ
clinmedi-179	194	31	in	in	ADP
clinmedi-179	194	32	patients	patient	NOUN
clinmedi-179	194	33	with	with	ADP
clinmedi-179	194	34	metastatic	metastatic	ADJ
clinmedi-179	194	35	breast	breast	NOUN
clinmedi-179	194	36	cancer	cancer	NOUN
clinmedi-179	194	37	.	.	PUNCT
clinmedi-179	195	1	breast	breast	NOUN
clinmedi-179	195	2	2021	2021	NUM
clinmedi-179	195	3	;	;	PUNCT
clinmedi-179	195	4	55	55	NUM
clinmedi-179	195	5	:	:	PUNCT
clinmedi-179	195	6	63–8	63–8	X
clinmedi-179	195	7	.	.	PUNCT