id	sid	tid	token	lemma	pos
ct-10124	1	1	2013	2013	NUM
ct-10124	1	2	:	:	PUNCT
ct-10124	1	3	antimicrobial	antimicrobial	ADJ
ct-10124	1	4	therapy	therapy	NOUN
ct-10124	1	5	in	in	ADP
ct-10124	1	6	foals	foal	NOUN
ct-10124	1	7	antimicrobial	antimicrobial	ADJ
ct-10124	1	8	therapy	therapy	NOUN
ct-10124	1	9	in	in	ADP
ct-10124	1	10	foals	foal	NOUN
ct-10124	1	11	steeve	steeve	PROPN
ct-10124	1	12	giguère	giguère	PROPN
ct-10124	1	13	college	college	PROPN
ct-10124	1	14	of	of	ADP
ct-10124	1	15	veterinary	veterinary	ADJ
ct-10124	1	16	medicine	medicine	NOUN
ct-10124	1	17	,	,	PUNCT
ct-10124	1	18	university	university	NOUN
ct-10124	1	19	of	of	ADP
ct-10124	1	20	georgia	georgia	PROPN
ct-10124	1	21	,	,	PUNCT
ct-10124	1	22	athens	athens	PROPN
ct-10124	1	23	,	,	PUNCT
ct-10124	1	24	ga	ga	PROPN
ct-10124	1	25	antimicrobial	antimicrobial	ADJ
ct-10124	1	26	therapy	therapy	NOUN
ct-10124	1	27	has	have	AUX
ct-10124	1	28	long	long	ADV
ct-10124	1	29	played	play	VERB
ct-10124	1	30	a	a	DET
ct-10124	1	31	vital	vital	ADJ
ct-10124	1	32	role	role	NOUN
ct-10124	1	33	in	in	ADP
ct-10124	1	34	the	the	DET
ct-10124	1	35	treatment	treatment	NOUN
ct-10124	1	36	of	of	ADP
ct-10124	1	37	equine	equine	NOUN
ct-10124	1	38	bacterial	bacterial	ADJ
ct-10124	1	39	diseases	disease	NOUN
ct-10124	1	40	.	.	PUNCT
ct-10124	2	1	however	however	ADV
ct-10124	2	2	,	,	PUNCT
ct-10124	2	3	the	the	DET
ct-10124	2	4	arsenal	arsenal	NOUN
ct-10124	2	5	of	of	ADP
ct-10124	2	6	equine	equine	NOUN
ct-10124	2	7	-	-	PUNCT
ct-10124	2	8	approved	approve	VERB
ct-10124	2	9	antimicrobial	antimicrobial	ADJ
ct-10124	2	10	agents	agent	NOUN
ct-10124	2	11	available	available	ADJ
ct-10124	2	12	to	to	ADP
ct-10124	2	13	veterinarians	veterinarian	NOUN
ct-10124	2	14	is	be	AUX
ct-10124	2	15	limited	limited	ADJ
ct-10124	2	16	.	.	PUNCT
ct-10124	3	1	few	few	ADJ
ct-10124	3	2	antimicrobial	antimicrobial	ADJ
ct-10124	3	3	drugs	drug	NOUN
ct-10124	3	4	are	be	AUX
ct-10124	3	5	licensed	license	VERB
ct-10124	3	6	for	for	ADP
ct-10124	3	7	use	use	NOUN
ct-10124	3	8	in	in	ADP
ct-10124	3	9	horses	horse	NOUN
ct-10124	3	10	,	,	PUNCT
ct-10124	3	11	often	often	ADV
ct-10124	3	12	requiring	require	VERB
ct-10124	3	13	the	the	DET
ct-10124	3	14	clinician	clinician	NOUN
ct-10124	3	15	to	to	PART
ct-10124	3	16	resort	resort	VERB
ct-10124	3	17	to	to	ADP
ct-10124	3	18	extra	extra	ADJ
ct-10124	3	19	-	-	ADJ
ct-10124	3	20	label	label	ADJ
ct-10124	3	21	use	use	NOUN
ct-10124	3	22	.	.	PUNCT
ct-10124	4	1	unfortunately	unfortunately	ADV
ct-10124	4	2	,	,	PUNCT
ct-10124	4	3	many	many	ADJ
ct-10124	4	4	human	human	ADJ
ct-10124	4	5	drugs	drug	NOUN
ct-10124	4	6	are	be	AUX
ct-10124	4	7	not	not	PART
ct-10124	4	8	appropriate	appropriate	ADJ
ct-10124	4	9	for	for	ADP
ct-10124	4	10	use	use	NOUN
ct-10124	4	11	in	in	ADP
ct-10124	4	12	horses	horse	NOUN
ct-10124	4	13	because	because	SCONJ
ct-10124	4	14	of	of	ADP
ct-10124	4	15	poor	poor	ADJ
ct-10124	4	16	oral	oral	ADJ
ct-10124	4	17	bioavailability	bioavailability	NOUN
ct-10124	4	18	,	,	PUNCT
ct-10124	4	19	cost	cost	NOUN
ct-10124	4	20	,	,	PUNCT
ct-10124	4	21	lack	lack	NOUN
ct-10124	4	22	of	of	ADP
ct-10124	4	23	species	specie	NOUN
ct-10124	4	24	-	-	PUNCT
ct-10124	4	25	specific	specific	ADJ
ct-10124	4	26	pharmacokinetic	pharmacokinetic	ADJ
ct-10124	4	27	data	datum	NOUN
ct-10124	4	28	,	,	PUNCT
ct-10124	4	29	or	or	CCONJ
ct-10124	4	30	risk	risk	NOUN
ct-10124	4	31	of	of	ADP
ct-10124	4	32	serious	serious	ADJ
ct-10124	4	33	adverse	adverse	ADJ
ct-10124	4	34	effects	effect	NOUN
ct-10124	4	35	such	such	ADJ
ct-10124	4	36	as	as	ADP
ct-10124	4	37	enterocolitis	enterocolitis	ADJ
ct-10124	4	38	.	.	PUNCT
ct-10124	5	1	while	while	SCONJ
ct-10124	5	2	development	development	NOUN
ct-10124	5	3	of	of	ADP
ct-10124	5	4	new	new	ADJ
ct-10124	5	5	antimicrobials	antimicrobial	NOUN
ct-10124	5	6	initially	initially	ADV
ct-10124	5	7	outpaced	outpace	VERB
ct-10124	5	8	development	development	NOUN
ct-10124	5	9	of	of	ADP
ct-10124	5	10	bacterial	bacterial	ADJ
ct-10124	5	11	resistance	resistance	NOUN
ct-10124	5	12	,	,	PUNCT
ct-10124	5	13	the	the	DET
ct-10124	5	14	trend	trend	NOUN
ct-10124	5	15	has	have	AUX
ct-10124	5	16	reversed	reverse	VERB
ct-10124	5	17	over	over	ADP
ct-10124	5	18	the	the	DET
ct-10124	5	19	last	last	ADJ
ct-10124	5	20	10	10	NUM
ct-10124	5	21	years	year	NOUN
ct-10124	5	22	.	.	PUNCT
ct-10124	6	1	this	this	PRON
ct-10124	6	2	has	have	AUX
ct-10124	6	3	resulted	result	VERB
ct-10124	6	4	in	in	ADP
ct-10124	6	5	emergence	emergence	NOUN
ct-10124	6	6	of	of	ADP
ct-10124	6	7	resistant	resistant	ADJ
ct-10124	6	8	bacteria	bacteria	NOUN
ct-10124	6	9	as	as	ADP
ct-10124	6	10	a	a	DET
ct-10124	6	11	major	major	ADJ
ct-10124	6	12	problem	problem	NOUN
ct-10124	6	13	worldwide	worldwide	ADV
ct-10124	6	14	.	.	PUNCT
ct-10124	7	1	although	although	SCONJ
ct-10124	7	2	any	any	DET
ct-10124	7	3	use	use	NOUN
ct-10124	7	4	of	of	ADP
ct-10124	7	5	antimicrobials	antimicrobial	NOUN
ct-10124	7	6	has	have	VERB
ct-10124	7	7	the	the	DET
ct-10124	7	8	potential	potential	NOUN
ct-10124	7	9	to	to	PART
ct-10124	7	10	contribute	contribute	VERB
ct-10124	7	11	to	to	ADP
ct-10124	7	12	development	development	NOUN
ct-10124	7	13	of	of	ADP
ct-10124	7	14	resistance	resistance	NOUN
ct-10124	7	15	,	,	PUNCT
ct-10124	7	16	antimicrobial	antimicrobial	ADJ
ct-10124	7	17	therapy	therapy	NOUN
ct-10124	7	18	is	be	AUX
ct-10124	7	19	vital	vital	ADJ
ct-10124	7	20	for	for	ADP
ct-10124	7	21	controlling	control	VERB
ct-10124	7	22	equine	equine	NOUN
ct-10124	7	23	infectious	infectious	ADJ
ct-10124	7	24	disease	disease	NOUN
ct-10124	7	25	.	.	PUNCT
ct-10124	8	1	thus	thus	ADV
ct-10124	8	2	,	,	PUNCT
ct-10124	8	3	it	it	PRON
ct-10124	8	4	is	be	AUX
ct-10124	8	5	the	the	DET
ct-10124	8	6	veterinarian	veterinarian	NOUN
ct-10124	8	7	’s	’s	PART
ct-10124	8	8	responsibility	responsibility	NOUN
ct-10124	8	9	to	to	PART
ct-10124	8	10	use	use	VERB
ct-10124	8	11	antimicrobials	antimicrobial	NOUN
ct-10124	8	12	judiciously	judiciously	ADV
ct-10124	8	13	.	.	PUNCT
ct-10124	9	1	in	in	ADP
ct-10124	9	2	general	general	ADJ
ct-10124	9	3	terms	term	NOUN
ct-10124	9	4	,	,	PUNCT
ct-10124	9	5	judicious	judicious	ADJ
ct-10124	9	6	use	use	NOUN
ct-10124	9	7	is	be	AUX
ct-10124	9	8	defined	define	VERB
ct-10124	9	9	as	as	ADP
ct-10124	9	10	the	the	DET
ct-10124	9	11	optimal	optimal	ADJ
ct-10124	9	12	selection	selection	NOUN
ct-10124	9	13	of	of	ADP
ct-10124	9	14	a	a	DET
ct-10124	9	15	drug	drug	NOUN
ct-10124	9	16	,	,	PUNCT
ct-10124	9	17	dose	dose	NOUN
ct-10124	9	18	,	,	PUNCT
ct-10124	9	19	dosing	dosing	NOUN
ct-10124	9	20	interval	interval	NOUN
ct-10124	9	21	,	,	PUNCT
ct-10124	9	22	and	and	CCONJ
ct-10124	9	23	duration	duration	NOUN
ct-10124	9	24	of	of	ADP
ct-10124	9	25	therapy	therapy	NOUN
ct-10124	9	26	along	along	ADP
ct-10124	9	27	with	with	ADP
ct-10124	9	28	reduction	reduction	NOUN
ct-10124	9	29	of	of	ADP
ct-10124	9	30	inappropriate	inappropriate	ADJ
ct-10124	9	31	or	or	CCONJ
ct-10124	9	32	excessive	excessive	ADJ
ct-10124	9	33	use	use	NOUN
ct-10124	9	34	of	of	ADP
ct-10124	9	35	antimicrobials	antimicrobial	NOUN
ct-10124	9	36	.	.	PUNCT
ct-10124	10	1	judicious	judicious	ADJ
ct-10124	10	2	use	use	NOUN
ct-10124	10	3	of	of	ADP
ct-10124	10	4	antimicrobials	antimicrobial	NOUN
ct-10124	10	5	is	be	AUX
ct-10124	10	6	essential	essential	ADJ
ct-10124	10	7	to	to	PART
ct-10124	10	8	maximize	maximize	VERB
ct-10124	10	9	treatment	treatment	NOUN
ct-10124	10	10	efficacy	efficacy	NOUN
ct-10124	10	11	while	while	SCONJ
ct-10124	10	12	minimizing	minimize	VERB
ct-10124	10	13	development	development	NOUN
ct-10124	10	14	of	of	ADP
ct-10124	10	15	bacterial	bacterial	ADJ
ct-10124	10	16	resistance	resistance	NOUN
ct-10124	10	17	,	,	PUNCT
ct-10124	10	18	occurrence	occurrence	NOUN
ct-10124	10	19	of	of	ADP
ct-10124	10	20	adverse	adverse	ADJ
ct-10124	10	21	reactions	reaction	NOUN
ct-10124	10	22	,	,	PUNCT
ct-10124	10	23	and	and	CCONJ
ct-10124	10	24	relapses	relapse	NOUN
ct-10124	10	25	.	.	PUNCT
ct-10124	11	1	this	this	DET
ct-10124	11	2	technical	technical	ADJ
ct-10124	11	3	bulletin	bulletin	NOUN
ct-10124	11	4	provides	provide	VERB
ct-10124	11	5	an	an	DET
ct-10124	11	6	overview	overview	NOUN
ct-10124	11	7	of	of	ADP
ct-10124	11	8	current	current	ADJ
ct-10124	11	9	concepts	concept	NOUN
ct-10124	11	10	that	that	PRON
ct-10124	11	11	guide	guide	VERB
ct-10124	11	12	rational	rational	ADJ
ct-10124	11	13	antimicrobial	antimicrobial	ADJ
ct-10124	11	14	therapy	therapy	NOUN
ct-10124	11	15	in	in	ADP
ct-10124	11	16	horses	horse	NOUN
ct-10124	11	17	.	.	PUNCT
ct-10124	12	1	general	general	ADJ
ct-10124	12	2	principles	principle	NOUN
ct-10124	12	3	of	of	ADP
ct-10124	12	4	antimicrobial	antimicrobial	ADJ
ct-10124	12	5	drug	drug	NOUN
ct-10124	12	6	use	use	NOUN
ct-10124	12	7	in	in	ADP
ct-10124	12	8	horses	horse	NOUN
ct-10124	12	9	a	a	DET
ct-10124	12	10	variety	variety	NOUN
ct-10124	12	11	of	of	ADP
ct-10124	12	12	veterinary	veterinary	ADJ
ct-10124	12	13	organizations	organization	NOUN
ct-10124	12	14	have	have	AUX
ct-10124	12	15	developed	develop	VERB
ct-10124	12	16	generic	generic	ADJ
ct-10124	12	17	recommendations	recommendation	NOUN
ct-10124	12	18	for	for	ADP
ct-10124	12	19	judicious	judicious	ADJ
ct-10124	12	20	antimicrobial	antimicrobial	ADJ
ct-10124	12	21	drug	drug	NOUN
ct-10124	12	22	use	use	NOUN
ct-10124	12	23	.	.	PUNCT
ct-10124	13	1	the	the	DET
ct-10124	13	2	most	most	ADV
ct-10124	13	3	comprehensive	comprehensive	ADJ
ct-10124	13	4	guidelines	guideline	NOUN
ct-10124	13	5	for	for	ADP
ct-10124	13	6	equine	equine	NOUN
ct-10124	13	7	practitioners	practitioner	NOUN
ct-10124	13	8	is	be	AUX
ct-10124	13	9	a	a	DET
ct-10124	13	10	consensus	consensus	NOUN
ct-10124	13	11	statement	statement	NOUN
ct-10124	13	12	issued	issue	VERB
ct-10124	13	13	by	by	ADP
ct-10124	13	14	the	the	DET
ct-10124	13	15	american	american	PROPN
ct-10124	13	16	college	college	PROPN
ct-10124	13	17	of	of	ADP
ct-10124	13	18	veterinary	veterinary	ADJ
ct-10124	13	19	internal	internal	PROPN
ct-10124	13	20	medicine.1	medicine.1	PROPN
ct-10124	13	21	based	base	VERB
ct-10124	13	22	on	on	ADP
ct-10124	13	23	these	these	DET
ct-10124	13	24	guidelines	guideline	NOUN
ct-10124	13	25	,	,	PUNCT
ct-10124	13	26	key	key	ADJ
ct-10124	13	27	prudent	prudent	ADJ
ct-10124	13	28	-	-	PUNCT
ct-10124	13	29	use	use	NOUN
ct-10124	13	30	principles	principle	NOUN
ct-10124	13	31	are	be	AUX
ct-10124	13	32	:	:	PUNCT
ct-10124	13	33			PRON
ct-10124	13	34	antimicrobials	antimicrobial	NOUN
ct-10124	13	35	should	should	AUX
ct-10124	13	36	only	only	ADV
ct-10124	13	37	be	be	AUX
ct-10124	13	38	used	use	VERB
ct-10124	13	39	when	when	SCONJ
ct-10124	13	40	there	there	PRON
ct-10124	13	41	is	be	VERB
ct-10124	13	42	a	a	DET
ct-10124	13	43	reasonable	reasonable	ADJ
ct-10124	13	44	likelihood	likelihood	NOUN
ct-10124	13	45	that	that	SCONJ
ct-10124	13	46	a	a	DET
ct-10124	13	47	bacterial	bacterial	ADJ
ct-10124	13	48	infection	infection	NOUN
ct-10124	13	49	is	be	AUX
ct-10124	13	50	present	present	ADJ
ct-10124	13	51	.	.	PUNCT
ct-10124	14	1			X
ct-10124	14	2	whenever	whenever	SCONJ
ct-10124	14	3	possible	possible	ADJ
ct-10124	14	4	,	,	PUNCT
ct-10124	14	5	antimicrobial	antimicrobial	ADJ
ct-10124	14	6	therapy	therapy	NOUN
ct-10124	14	7	should	should	AUX
ct-10124	14	8	be	be	AUX
ct-10124	14	9	based	base	VERB
ct-10124	14	10	on	on	ADP
ct-10124	14	11	culture	culture	NOUN
ct-10124	14	12	and	and	CCONJ
ct-10124	14	13	in	in	ADP
ct-10124	14	14	vitro	vitro	X
ct-10124	14	15	susceptibility	susceptibility	NOUN
ct-10124	14	16	results	result	NOUN
ct-10124	14	17	.	.	PUNCT
ct-10124	15	1			X
ct-10124	15	2	a	a	DET
ct-10124	15	3	drug	drug	NOUN
ct-10124	15	4	with	with	ADP
ct-10124	15	5	a	a	DET
ct-10124	15	6	spectrum	spectrum	NOUN
ct-10124	15	7	of	of	ADP
ct-10124	15	8	activity	activity	NOUN
ct-10124	15	9	as	as	ADV
ct-10124	15	10	narrow	narrow	ADJ
ct-10124	15	11	as	as	ADP
ct-10124	15	12	possible	possible	ADJ
ct-10124	15	13	should	should	AUX
ct-10124	15	14	be	be	AUX
ct-10124	15	15	selected	select	VERB
ct-10124	15	16	.	.	PUNCT
ct-10124	16	1			X
ct-10124	16	2	extra	extra	ADJ
ct-10124	16	3	-	-	ADJ
ct-10124	16	4	label	label	ADJ
ct-10124	16	5	use	use	NOUN
ct-10124	16	6	should	should	AUX
ct-10124	16	7	be	be	AUX
ct-10124	16	8	avoided	avoid	VERB
ct-10124	16	9	when	when	SCONJ
ct-10124	16	10	on	on	ADP
ct-10124	16	11	-	-	PUNCT
ct-10124	16	12	label	label	NOUN
ct-10124	16	13	options	option	NOUN
ct-10124	16	14	are	be	AUX
ct-10124	16	15	available	available	ADJ
ct-10124	16	16	.	.	PUNCT
ct-10124	17	1			X
ct-10124	17	2	antimicrobial	antimicrobial	ADJ
ct-10124	17	3	agents	agent	NOUN
ct-10124	17	4	should	should	AUX
ct-10124	17	5	be	be	AUX
ct-10124	17	6	used	use	VERB
ct-10124	17	7	for	for	ADP
ct-10124	17	8	as	as	ADV
ct-10124	17	9	short	short	ADJ
ct-10124	17	10	a	a	DET
ct-10124	17	11	period	period	NOUN
ct-10124	17	12	as	as	ADP
ct-10124	17	13	necessary	necessary	ADJ
ct-10124	17	14	.	.	PUNCT
ct-10124	18	1			PRON
ct-10124	18	2	antimicrobials	antimicrobial	NOUN
ct-10124	18	3	that	that	PRON
ct-10124	18	4	are	be	AUX
ct-10124	18	5	important	important	ADJ
ct-10124	18	6	for	for	ADP
ct-10124	18	7	treating	treat	VERB
ct-10124	18	8	refractory	refractory	NOUN
ct-10124	18	9	or	or	CCONJ
ct-10124	18	10	serious	serious	ADJ
ct-10124	18	11	infections	infection	NOUN
ct-10124	18	12	in	in	ADP
ct-10124	18	13	humans	human	NOUN
ct-10124	18	14	should	should	AUX
ct-10124	18	15	be	be	AUX
ct-10124	18	16	reserved	reserve	VERB
ct-10124	18	17	and	and	CCONJ
ct-10124	18	18	only	only	ADV
ct-10124	18	19	used	use	VERB
ct-10124	18	20	after	after	ADP
ct-10124	18	21	careful	careful	ADJ
ct-10124	18	22	consideration	consideration	NOUN
ct-10124	18	23	,	,	PUNCT
ct-10124	18	24	and	and	CCONJ
ct-10124	18	25	only	only	ADV
ct-10124	18	26	when	when	SCONJ
ct-10124	18	27	culture	culture	NOUN
ct-10124	18	28	and	and	CCONJ
ct-10124	18	29	susceptibility	susceptibility	NOUN
ct-10124	18	30	results	result	NOUN
ct-10124	18	31	indicate	indicate	VERB
ct-10124	18	32	that	that	SCONJ
ct-10124	18	33	there	there	PRON
ct-10124	18	34	are	be	VERB
ct-10124	18	35	no	no	DET
ct-10124	18	36	alternatives	alternative	NOUN
ct-10124	18	37	.	.	PUNCT
ct-10124	19	1			NOUN
ct-10124	19	2	methods	method	NOUN
ct-10124	19	3	to	to	PART
ct-10124	19	4	decrease	decrease	VERB
ct-10124	19	5	the	the	DET
ct-10124	19	6	risk	risk	NOUN
ct-10124	19	7	and	and	CCONJ
ct-10124	19	8	incidence	incidence	NOUN
ct-10124	19	9	of	of	ADP
ct-10124	19	10	infection	infection	NOUN
ct-10124	19	11	should	should	AUX
ct-10124	19	12	be	be	AUX
ct-10124	19	13	emphasized	emphasize	VERB
ct-10124	19	14	in	in	ADP
ct-10124	19	15	order	order	NOUN
ct-10124	19	16	to	to	PART
ct-10124	19	17	decrease	decrease	VERB
ct-10124	19	18	the	the	DET
ct-10124	19	19	need	need	NOUN
ct-10124	19	20	for	for	ADP
ct-10124	19	21	antimicrobials	antimicrobial	NOUN
ct-10124	19	22	.	.	PUNCT
ct-10124	20	1	to	to	PART
ct-10124	20	2	underscore	underscore	VERB
ct-10124	20	3	the	the	DET
ct-10124	20	4	last	last	ADJ
ct-10124	20	5	point	point	NOUN
ct-10124	20	6	,	,	PUNCT
ct-10124	20	7	antimicrobial	antimicrobial	ADJ
ct-10124	20	8	therapy	therapy	NOUN
ct-10124	20	9	should	should	AUX
ct-10124	20	10	never	never	ADV
ct-10124	20	11	be	be	AUX
ct-10124	20	12	used	use	VERB
ct-10124	20	13	as	as	ADP
ct-10124	20	14	a	a	DET
ct-10124	20	15	substitute	substitute	NOUN
ct-10124	20	16	for	for	ADP
ct-10124	20	17	good	good	ADJ
ct-10124	20	18	disease	disease	NOUN
ct-10124	20	19	control	control	NOUN
ct-10124	20	20	and	and	CCONJ
ct-10124	20	21	hygiene	hygiene	NOUN
ct-10124	20	22	,	,	PUNCT
ct-10124	20	23	appropriate	appropriate	ADJ
ct-10124	20	24	medical	medical	ADJ
ct-10124	20	25	and	and	CCONJ
ct-10124	20	26	surgical	surgical	ADJ
ct-10124	20	27	practices	practice	NOUN
ct-10124	20	28	,	,	PUNCT
ct-10124	20	29	or	or	CCONJ
ct-10124	20	30	as	as	ADP
ct-10124	20	31	an	an	DET
ct-10124	20	32	alternative	alternative	NOUN
ct-10124	20	33	to	to	PART
ct-10124	20	34	sound	sound	VERB
ct-10124	20	35	animal	animal	NOUN
ct-10124	20	36	husbandry	husbandry	NOUN
ct-10124	20	37	.	.	PUNCT
ct-10124	21	1	in	in	ADP
ct-10124	21	2	choosing	choose	VERB
ct-10124	21	3	the	the	DET
ct-10124	21	4	appropriate	appropriate	ADJ
ct-10124	21	5	antimicrobial	antimicrobial	ADJ
ct-10124	21	6	agent	agent	NOUN
ct-10124	21	7	,	,	PUNCT
ct-10124	21	8	the	the	DET
ct-10124	21	9	clinician	clinician	NOUN
ct-10124	21	10	must	must	AUX
ct-10124	21	11	consider	consider	VERB
ct-10124	21	12	a	a	DET
ct-10124	21	13	variety	variety	NOUN
ct-10124	21	14	of	of	ADP
ct-10124	21	15	factors	factor	NOUN
ct-10124	21	16	including	include	VERB
ct-10124	21	17	:	:	PUNCT
ct-10124	21	18	(	(	PUNCT
ct-10124	21	19	1	1	X
ct-10124	21	20	)	)	PUNCT
ct-10124	21	21	the	the	DET
ct-10124	21	22	likely	likely	ADJ
ct-10124	21	23	identity	identity	NOUN
ct-10124	21	24	of	of	ADP
ct-10124	21	25	the	the	DET
ct-10124	21	26	infecting	infecting	ADJ
ct-10124	21	27	microorganism(s	microorganism(s	PROPN
ct-10124	21	28	)	)	PUNCT
ct-10124	21	29	,	,	PUNCT
ct-10124	21	30	(	(	PUNCT
ct-10124	21	31	2	2	X
ct-10124	21	32	)	)	PUNCT
ct-10124	21	33	their	their	PRON
ct-10124	21	34	typical	typical	ADJ
ct-10124	21	35	in	in	ADP
ct-10124	21	36	vitro	vitro	X
ct-10124	21	37	susceptibility	susceptibility	NOUN
ct-10124	21	38	patterns	pattern	NOUN
ct-10124	21	39	or	or	CCONJ
ct-10124	21	40	the	the	DET
ct-10124	21	41	clinical	clinical	ADJ
ct-10124	21	42	response	response	NOUN
ct-10124	21	43	in	in	ADP
ct-10124	21	44	equine	equine	NOUN
ct-10124	21	45	patients	patient	NOUN
ct-10124	21	46	infected	infect	VERB
ct-10124	21	47	with	with	ADP
ct-10124	21	48	the	the	DET
ct-10124	21	49	same	same	ADJ
ct-10124	21	50	pathogens	pathogen	NOUN
ct-10124	21	51	,	,	PUNCT
ct-10124	21	52	(	(	PUNCT
ct-10124	21	53	3	3	X
ct-10124	21	54	)	)	PUNCT
ct-10124	21	55	the	the	DET
ct-10124	21	56	nature	nature	NOUN
ct-10124	21	57	and	and	CCONJ
ct-10124	21	58	site	site	NOUN
ct-10124	21	59	of	of	ADP
ct-10124	21	60	the	the	DET
ct-10124	21	61	infectious	infectious	ADJ
ct-10124	21	62	disease	disease	NOUN
ct-10124	21	63	process	process	NOUN
ct-10124	21	64	,	,	PUNCT
ct-10124	21	65	(	(	PUNCT
ct-10124	21	66	4	4	X
ct-10124	21	67	)	)	PUNCT
ct-10124	21	68	the	the	DET
ct-10124	21	69	pharmacokinetic	pharmacokinetic	ADJ
ct-10124	21	70	characteristics	characteristic	NOUN
ct-10124	21	71	of	of	ADP
ct-10124	21	72	the	the	DET
ct-10124	21	73	chosen	choose	VERB
ct-10124	21	74	antimicrobial	antimicrobial	ADJ
ct-10124	21	75	agent	agent	NOUN
ct-10124	21	76	in	in	ADP
ct-10124	21	77	horses	horse	NOUN
ct-10124	21	78	such	such	ADJ
ct-10124	21	79	as	as	ADP
ct-10124	21	80	bioavailability	bioavailability	NOUN
ct-10124	21	81	,	,	PUNCT
ct-10124	21	82	tissue	tissue	NOUN
ct-10124	21	83	distribution	distribution	NOUN
ct-10124	21	84	,	,	PUNCT
ct-10124	21	85	and	and	CCONJ
ct-10124	21	86	rate	rate	NOUN
ct-10124	21	87	of	of	ADP
ct-10124	21	88	elimination	elimination	NOUN
ct-10124	21	89	,	,	PUNCT
ct-10124	21	90	(	(	PUNCT
ct-10124	21	91	5	5	X
ct-10124	21	92	)	)	PUNCT
ct-10124	21	93	the	the	DET
ct-10124	21	94	pharmacodynamic	pharmacodynamic	ADJ
ct-10124	21	95	properties	property	NOUN
ct-10124	21	96	of	of	ADP
ct-10124	21	97	the	the	DET
ct-10124	21	98	antimicrobial	antimicrobial	ADJ
ct-10124	21	99	agent	agent	NOUN
ct-10124	21	100	selected	select	VERB
ct-10124	21	101	,	,	PUNCT
ct-10124	21	102	(	(	PUNCT
ct-10124	21	103	6	6	X
ct-10124	21	104	)	)	PUNCT
ct-10124	21	105	its	its	PRON
ct-10124	21	106	safety	safety	NOUN
ct-10124	21	107	in	in	ADP
ct-10124	21	108	horses	horse	NOUN
ct-10124	21	109	,	,	PUNCT
ct-10124	21	110	and	and	CCONJ
ct-10124	21	111	(	(	PUNCT
ct-10124	21	112	7	7	X
ct-10124	21	113	)	)	PUNCT
ct-10124	21	114	the	the	DET
ct-10124	21	115	cost	cost	NOUN
ct-10124	21	116	of	of	ADP
ct-10124	21	117	therapy	therapy	NOUN
ct-10124	21	118	.	.	PUNCT
ct-10124	22	1	in	in	ADP
ct-10124	22	2	all	all	DET
ct-10124	22	3	situations	situation	NOUN
ct-10124	22	4	,	,	PUNCT
ct-10124	22	5	therapy	therapy	NOUN
ct-10124	22	6	should	should	AUX
ct-10124	22	7	be	be	AUX
ct-10124	22	8	adjusted	adjust	VERB
ct-10124	22	9	based	base	VERB
ct-10124	22	10	on	on	ADP
ct-10124	22	11	initial	initial	ADJ
ct-10124	22	12	clinical	clinical	ADJ
ct-10124	22	13	response	response	NOUN
ct-10124	22	14	and	and	CCONJ
ct-10124	22	15	,	,	PUNCT
ct-10124	22	16	when	when	SCONJ
ct-10124	22	17	available	available	ADJ
ct-10124	22	18	,	,	PUNCT
ct-10124	22	19	results	result	NOUN
ct-10124	22	20	of	of	ADP
ct-10124	22	21	culture	culture	NOUN
ct-10124	22	22	and	and	CCONJ
ct-10124	22	23	susceptibility	susceptibility	NOUN
ct-10124	22	24	testing	testing	NOUN
ct-10124	22	25	.	.	PUNCT
ct-10124	23	1	517	517	NUM
ct-10124	23	2	clinical	clinical	ADJ
ct-10124	23	3	theriogenology	theriogenology	NOUN
ct-10124	23	4	•	•	NOUN
ct-10124	23	5	volume	volume	NOUN
ct-10124	23	6	5	5	NUM
ct-10124	23	7	,	,	PUNCT
ct-10124	23	8	number	number	NOUN
ct-10124	23	9	4	4	NUM
ct-10124	23	10	•	•	NOUN
ct-10124	23	11	december	december	PROPN
ct-10124	23	12	2013	2013	NUM
ct-10124	23	13	common	common	ADJ
ct-10124	23	14	bacterial	bacterial	ADJ
ct-10124	23	15	pathogens	pathogen	NOUN
ct-10124	23	16	of	of	ADP
ct-10124	23	17	horses	horse	NOUN
ct-10124	23	18	and	and	CCONJ
ct-10124	23	19	their	their	PRON
ct-10124	23	20	typical	typical	ADJ
ct-10124	23	21	susceptibility	susceptibility	NOUN
ct-10124	23	22	patterns	pattern	NOUN
ct-10124	23	23	because	because	SCONJ
ct-10124	23	24	the	the	DET
ct-10124	23	25	identity	identity	NOUN
ct-10124	23	26	and	and	CCONJ
ct-10124	23	27	in	in	ADP
ct-10124	23	28	vitro	vitro	X
ct-10124	23	29	susceptibility	susceptibility	NOUN
ct-10124	23	30	of	of	ADP
ct-10124	23	31	an	an	DET
ct-10124	23	32	infecting	infect	VERB
ct-10124	23	33	microorganism	microorganism	NOUN
ct-10124	23	34	are	be	AUX
ct-10124	23	35	rarely	rarely	ADV
ct-10124	23	36	known	know	VERB
ct-10124	23	37	when	when	SCONJ
ct-10124	23	38	therapy	therapy	NOUN
ct-10124	23	39	is	be	AUX
ct-10124	23	40	begun	begin	VERB
ct-10124	23	41	,	,	PUNCT
ct-10124	23	42	initial	initial	ADJ
ct-10124	23	43	therapy	therapy	NOUN
ct-10124	23	44	is	be	AUX
ct-10124	23	45	usually	usually	ADV
ct-10124	23	46	empirical	empirical	ADJ
ct-10124	23	47	and	and	CCONJ
ct-10124	23	48	based	base	VERB
ct-10124	23	49	on	on	ADP
ct-10124	23	50	knowledge	knowledge	NOUN
ct-10124	23	51	of	of	ADP
ct-10124	23	52	the	the	DET
ct-10124	23	53	agents	agent	NOUN
ct-10124	23	54	likely	likely	ADJ
ct-10124	23	55	to	to	PART
ct-10124	23	56	be	be	AUX
ct-10124	23	57	present	present	ADJ
ct-10124	23	58	and	and	CCONJ
ct-10124	23	59	their	their	PRON
ct-10124	23	60	historical	historical	ADJ
ct-10124	23	61	susceptibility	susceptibility	NOUN
ct-10124	23	62	.	.	PUNCT
ct-10124	24	1	in	in	ADP
ct-10124	24	2	some	some	DET
ct-10124	24	3	cases	case	NOUN
ct-10124	24	4	,	,	PUNCT
ct-10124	24	5	the	the	DET
ct-10124	24	6	most	most	ADV
ct-10124	24	7	likely	likely	ADJ
ct-10124	24	8	etiologic	etiologic	ADJ
ct-10124	24	9	agent	agent	NOUN
ct-10124	24	10	is	be	AUX
ct-10124	24	11	highly	highly	ADV
ct-10124	24	12	predictable	predictable	ADJ
ct-10124	24	13	based	base	VERB
ct-10124	24	14	on	on	ADP
ct-10124	24	15	the	the	DET
ct-10124	24	16	clinical	clinical	ADJ
ct-10124	24	17	presentation	presentation	NOUN
ct-10124	24	18	and	and	CCONJ
ct-10124	24	19	the	the	DET
ct-10124	24	20	horse	horse	NOUN
ct-10124	24	21	’s	’s	PART
ct-10124	24	22	history	history	NOUN
ct-10124	24	23	.	.	PUNCT
ct-10124	25	1	for	for	ADP
ct-10124	25	2	example	example	NOUN
ct-10124	25	3	,	,	PUNCT
ct-10124	25	4	abscessation	abscessation	NOUN
ct-10124	25	5	of	of	ADP
ct-10124	25	6	the	the	DET
ct-10124	25	7	submandibular	submandibular	ADJ
ct-10124	25	8	and	and	CCONJ
ct-10124	25	9	retropharyngeal	retropharyngeal	ADJ
ct-10124	25	10	lymph	lymph	NOUN
ct-10124	25	11	nodes	node	NOUN
ct-10124	25	12	is	be	AUX
ct-10124	25	13	most	most	ADV
ct-10124	25	14	likely	likely	ADV
ct-10124	25	15	caused	cause	VERB
ct-10124	25	16	by	by	ADP
ct-10124	25	17	streptococcus	streptococcus	NOUN
ct-10124	25	18	equi	equi	NOUN
ct-10124	25	19	subspecies	subspecie	NOUN
ct-10124	25	20	equi	equi	NOUN
ct-10124	25	21	(	(	PUNCT
ct-10124	25	22	s.	s.	PROPN
ct-10124	25	23	equi	equi	PROPN
ct-10124	25	24	)	)	PUNCT
ct-10124	25	25	.	.	PUNCT
ct-10124	26	1	lower	low	ADJ
ct-10124	26	2	respiratory	respiratory	ADJ
ct-10124	26	3	tract	tract	NOUN
ct-10124	26	4	infection	infection	NOUN
ct-10124	26	5	in	in	ADP
ct-10124	26	6	adult	adult	NOUN
ct-10124	26	7	horses	horse	NOUN
ct-10124	26	8	is	be	AUX
ct-10124	26	9	most	most	ADV
ct-10124	26	10	commonly	commonly	ADV
ct-10124	26	11	associated	associate	VERB
ct-10124	26	12	with	with	ADP
ct-10124	26	13	s.	s.	PROPN
ct-10124	26	14	equi	equi	PROPN
ct-10124	26	15	subspecies	subspecie	NOUN
ct-10124	26	16	zooepidemicus	zooepidemicus	PROPN
ct-10124	26	17	(	(	PUNCT
ct-10124	26	18	s.	s.	PROPN
ct-10124	26	19	zooepidemicus	zooepidemicus	PROPN
ct-10124	26	20	)	)	PUNCT
ct-10124	26	21	,	,	PUNCT
ct-10124	26	22	followed	follow	VERB
ct-10124	26	23	by	by	ADP
ct-10124	26	24	non	non	ADJ
ct-10124	26	25	-	-	ADJ
ct-10124	26	26	enteric	enteric	ADJ
ct-10124	26	27	gram	gram	NOUN
ct-10124	26	28	-	-	PUNCT
ct-10124	26	29	negative	negative	ADJ
ct-10124	26	30	bacteria	bacteria	NOUN
ct-10124	26	31	such	such	ADJ
ct-10124	26	32	as	as	ADP
ct-10124	26	33	pasteurella	pasteurella	PROPN
ct-10124	26	34	spp	spp	NOUN
ct-10124	26	35	.	.	PUNCT
ct-10124	27	1	on	on	ADP
ct-10124	27	2	the	the	DET
ct-10124	27	3	other	other	ADJ
ct-10124	27	4	hand	hand	NOUN
ct-10124	27	5	,	,	PUNCT
ct-10124	27	6	pleuropneumonia	pleuropneumonia	NOUN
ct-10124	27	7	in	in	ADP
ct-10124	27	8	an	an	DET
ct-10124	27	9	adult	adult	NOUN
ct-10124	27	10	horse	horse	NOUN
ct-10124	27	11	may	may	AUX
ct-10124	27	12	be	be	AUX
ct-10124	27	13	caused	cause	VERB
ct-10124	27	14	by	by	ADP
ct-10124	27	15	any	any	DET
ct-10124	27	16	one	one	NUM
ct-10124	27	17	or	or	CCONJ
ct-10124	27	18	combinations	combination	NOUN
ct-10124	27	19	of	of	ADP
ct-10124	27	20	a	a	DET
ct-10124	27	21	number	number	NOUN
ct-10124	27	22	of	of	ADP
ct-10124	27	23	bacteria	bacteria	NOUN
ct-10124	27	24	and	and	CCONJ
ct-10124	27	25	thus	thus	ADV
ct-10124	27	26	requires	require	VERB
ct-10124	27	27	bacteriologic	bacteriologic	ADJ
ct-10124	27	28	culture	culture	NOUN
ct-10124	27	29	of	of	ADP
ct-10124	27	30	a	a	DET
ct-10124	27	31	tracheobronchial	tracheobronchial	ADJ
ct-10124	27	32	aspirate	aspirate	NOUN
ct-10124	27	33	and	and	CCONJ
ct-10124	27	34	pleural	pleural	ADJ
ct-10124	27	35	fluid	fluid	NOUN
ct-10124	27	36	to	to	PART
ct-10124	27	37	determine	determine	VERB
ct-10124	27	38	etiology	etiology	NOUN
ct-10124	27	39	.	.	PUNCT
ct-10124	28	1	similarly	similarly	ADV
ct-10124	28	2	,	,	PUNCT
ct-10124	28	3	peritonitis	peritonitis	NOUN
ct-10124	28	4	,	,	PUNCT
ct-10124	28	5	urinary	urinary	ADJ
ct-10124	28	6	tract	tract	NOUN
ct-10124	28	7	infections	infection	NOUN
ct-10124	28	8	,	,	PUNCT
ct-10124	28	9	musculoskeletal	musculoskeletal	ADJ
ct-10124	28	10	infections	infection	NOUN
ct-10124	28	11	,	,	PUNCT
ct-10124	28	12	cellulitis	cellulitis	NOUN
ct-10124	28	13	,	,	PUNCT
ct-10124	28	14	and	and	CCONJ
ct-10124	28	15	mastitis	mastitis	NOUN
ct-10124	28	16	may	may	AUX
ct-10124	28	17	be	be	AUX
ct-10124	28	18	caused	cause	VERB
ct-10124	28	19	by	by	ADP
ct-10124	28	20	a	a	DET
ct-10124	28	21	variety	variety	NOUN
ct-10124	28	22	of	of	ADP
ct-10124	28	23	bacteria	bacteria	NOUN
ct-10124	28	24	,	,	PUNCT
ct-10124	28	25	so	so	SCONJ
ct-10124	28	26	that	that	SCONJ
ct-10124	28	27	initial	initial	ADJ
ct-10124	28	28	therapy	therapy	NOUN
ct-10124	28	29	with	with	ADP
ct-10124	28	30	a	a	DET
ct-10124	28	31	broadspectrum	broadspectrum	NOUN
ct-10124	28	32	antimicrobial	antimicrobial	ADJ
ct-10124	28	33	agent	agent	NOUN
ct-10124	28	34	is	be	AUX
ct-10124	28	35	recommended	recommend	VERB
ct-10124	28	36	.	.	PUNCT
ct-10124	29	1	the	the	DET
ct-10124	29	2	selection	selection	NOUN
ct-10124	29	3	of	of	ADP
ct-10124	29	4	the	the	DET
ct-10124	29	5	antimicrobial	antimicrobial	ADJ
ct-10124	29	6	agent	agent	NOUN
ct-10124	29	7	and	and	CCONJ
ct-10124	29	8	route	route	NOUN
ct-10124	29	9	of	of	ADP
ct-10124	29	10	administration	administration	NOUN
ct-10124	29	11	will	will	AUX
ct-10124	29	12	depend	depend	VERB
ct-10124	29	13	on	on	ADP
ct-10124	29	14	severity	severity	NOUN
ct-10124	29	15	of	of	ADP
ct-10124	29	16	disease	disease	NOUN
ct-10124	29	17	and	and	CCONJ
ct-10124	29	18	site	site	NOUN
ct-10124	29	19	of	of	ADP
ct-10124	29	20	infection	infection	NOUN
ct-10124	29	21	.	.	PUNCT
ct-10124	30	1	many	many	ADJ
ct-10124	30	2	infectious	infectious	ADJ
ct-10124	30	3	diseases	disease	NOUN
ct-10124	30	4	involving	involve	VERB
ct-10124	30	5	the	the	DET
ct-10124	30	6	neonatal	neonatal	ADJ
ct-10124	30	7	foal	foal	NOUN
ct-10124	30	8	such	such	ADJ
ct-10124	30	9	as	as	ADP
ct-10124	30	10	pneumonia	pneumonia	NOUN
ct-10124	30	11	,	,	PUNCT
ct-10124	30	12	peritonitis	peritonitis	NOUN
ct-10124	30	13	,	,	PUNCT
ct-10124	30	14	meningitis	meningitis	NOUN
ct-10124	30	15	,	,	PUNCT
ct-10124	30	16	osteomyelitis	osteomyelitis	NOUN
ct-10124	30	17	,	,	PUNCT
ct-10124	30	18	septic	septic	ADJ
ct-10124	30	19	arthritis	arthritis	NOUN
ct-10124	30	20	,	,	PUNCT
ct-10124	30	21	and	and	CCONJ
ct-10124	30	22	omphalophlebitis	omphalophlebitis	NOUN
ct-10124	30	23	are	be	AUX
ct-10124	30	24	the	the	DET
ct-10124	30	25	sequelae	sequelae	NOUN
ct-10124	30	26	of	of	ADP
ct-10124	30	27	bacteremia	bacteremia	NOUN
ct-10124	30	28	.	.	PUNCT
ct-10124	31	1	gram	gram	NOUN
ct-10124	31	2	-	-	PUNCT
ct-10124	31	3	negative	negative	ADJ
ct-10124	31	4	bacteria	bacteria	NOUN
ct-10124	31	5	account	account	VERB
ct-10124	31	6	for	for	ADP
ct-10124	31	7	70	70	NUM
ct-10124	31	8	%	%	NOUN
ct-10124	31	9	to	to	PART
ct-10124	31	10	95	95	NUM
ct-10124	31	11	%	%	NOUN
ct-10124	31	12	of	of	ADP
ct-10124	31	13	the	the	DET
ct-10124	31	14	microorganisms	microorganism	NOUN
ct-10124	31	15	isolated	isolate	VERB
ct-10124	31	16	from	from	ADP
ct-10124	31	17	cultures	culture	NOUN
ct-10124	31	18	of	of	ADP
ct-10124	31	19	blood	blood	NOUN
ct-10124	31	20	samples	sample	NOUN
ct-10124	31	21	in	in	ADP
ct-10124	31	22	equine	equine	NOUN
ct-10124	31	23	neonates	neonate	NOUN
ct-10124	31	24	,	,	PUNCT
ct-10124	31	25	with	with	ADP
ct-10124	31	26	escherichia	escherichia	NOUN
ct-10124	31	27	coli	coli	NOUN
ct-10124	31	28	being	be	AUX
ct-10124	31	29	by	by	ADP
ct-10124	31	30	far	far	ADV
ct-10124	31	31	the	the	DET
ct-10124	31	32	most	most	ADV
ct-10124	31	33	common	common	ADJ
ct-10124	31	34	isolate.2,3	isolate.2,3	ADJ
ct-10124	31	35	gram	gram	NOUN
ct-10124	31	36	-	-	PUNCT
ct-10124	31	37	positive	positive	ADJ
ct-10124	31	38	cocci	cocci	NOUN
ct-10124	31	39	account	account	VERB
ct-10124	31	40	for	for	ADP
ct-10124	31	41	approximately	approximately	ADV
ct-10124	31	42	25	25	NUM
ct-10124	31	43	%	%	NOUN
ct-10124	31	44	of	of	ADP
ct-10124	31	45	isolates.4	isolates.4	PROPN
ct-10124	31	46	treatment	treatment	NOUN
ct-10124	31	47	protocols	protocol	NOUN
ct-10124	31	48	for	for	ADP
ct-10124	31	49	equine	equine	NOUN
ct-10124	31	50	neonates	neonate	NOUN
ct-10124	31	51	must	must	AUX
ct-10124	31	52	include	include	VERB
ct-10124	31	53	antimicrobials	antimicrobial	NOUN
ct-10124	31	54	with	with	ADP
ct-10124	31	55	a	a	DET
ct-10124	31	56	high	high	ADJ
ct-10124	31	57	level	level	NOUN
ct-10124	31	58	of	of	ADP
ct-10124	31	59	activity	activity	NOUN
ct-10124	31	60	against	against	ADP
ct-10124	31	61	enteric	enteric	ADJ
ct-10124	31	62	gram	gram	NOUN
ct-10124	31	63	-	-	PUNCT
ct-10124	31	64	negative	negative	ADJ
ct-10124	31	65	bacteria	bacteria	NOUN
ct-10124	31	66	while	while	SCONJ
ct-10124	31	67	providing	provide	VERB
ct-10124	31	68	adequate	adequate	ADJ
ct-10124	31	69	coverage	coverage	NOUN
ct-10124	31	70	against	against	ADP
ct-10124	31	71	gram	gram	NOUN
ct-10124	31	72	-	-	PUNCT
ct-10124	31	73	positive	positive	ADJ
ct-10124	31	74	microorganisms	microorganism	NOUN
ct-10124	31	75	.	.	PUNCT
ct-10124	32	1	bacteria	bacteria	NOUN
ct-10124	32	2	that	that	PRON
ct-10124	32	3	are	be	AUX
ct-10124	32	4	typically	typically	ADV
ct-10124	32	5	considered	consider	VERB
ct-10124	32	6	to	to	PART
ct-10124	32	7	be	be	AUX
ct-10124	32	8	contaminants	contaminant	NOUN
ct-10124	32	9	or	or	CCONJ
ct-10124	32	10	part	part	NOUN
ct-10124	32	11	of	of	ADP
ct-10124	32	12	the	the	DET
ct-10124	32	13	normal	normal	ADJ
ct-10124	32	14	microflora	microflora	NOUN
ct-10124	32	15	need	need	AUX
ct-10124	32	16	not	not	PART
ct-10124	32	17	be	be	AUX
ct-10124	32	18	tested	test	VERB
ct-10124	32	19	for	for	ADP
ct-10124	32	20	susceptibility	susceptibility	NOUN
ct-10124	32	21	.	.	PUNCT
ct-10124	33	1	however	however	ADV
ct-10124	33	2	,	,	PUNCT
ct-10124	33	3	when	when	SCONJ
ct-10124	33	4	pathogenic	pathogenic	ADJ
ct-10124	33	5	bacteria	bacteria	NOUN
ct-10124	33	6	are	be	AUX
ct-10124	33	7	identified	identify	VERB
ct-10124	33	8	,	,	PUNCT
ct-10124	33	9	selection	selection	NOUN
ct-10124	33	10	of	of	ADP
ct-10124	33	11	an	an	DET
ct-10124	33	12	antimicrobial	antimicrobial	ADJ
ct-10124	33	13	agent	agent	NOUN
ct-10124	33	14	is	be	AUX
ct-10124	33	15	often	often	ADV
ct-10124	33	16	simplified	simplify	VERB
ct-10124	33	17	because	because	SCONJ
ct-10124	33	18	some	some	DET
ct-10124	33	19	common	common	ADJ
ct-10124	33	20	equine	equine	NOUN
ct-10124	33	21	pathogens	pathogen	NOUN
ct-10124	33	22	have	have	AUX
ct-10124	33	23	predictable	predictable	ADJ
ct-10124	33	24	in	in	ADP
ct-10124	33	25	vitro	vitro	X
ct-10124	33	26	susceptibility	susceptibility	NOUN
ct-10124	33	27	profiles	profile	NOUN
ct-10124	33	28	.	.	PUNCT
ct-10124	34	1	for	for	ADP
ct-10124	34	2	example	example	NOUN
ct-10124	34	3	,	,	PUNCT
ct-10124	34	4	β	β	ADJ
ct-10124	34	5	-	-	ADJ
ct-10124	34	6	hemolytic	hemolytic	ADJ
ct-10124	34	7	streptococci	streptococci	NOUN
ct-10124	34	8	and	and	CCONJ
ct-10124	34	9	pasteurella	pasteurella	PROPN
ct-10124	34	10	spp	spp	PROPN
ct-10124	34	11	.	.	PUNCT
ct-10124	34	12	are	be	AUX
ct-10124	34	13	almost	almost	ADV
ct-10124	34	14	invariably	invariably	ADV
ct-10124	34	15	susceptible	susceptible	ADJ
ct-10124	34	16	to	to	ADP
ct-10124	34	17	penicillin	penicillin	PROPN
ct-10124	34	18	,	,	PUNCT
ct-10124	34	19	ampicillin	ampicillin	PROPN
ct-10124	34	20	,	,	PUNCT
ct-10124	34	21	and	and	CCONJ
ct-10124	34	22	ceftiofur	ceftiofur	NOUN
ct-10124	34	23	.	.	PUNCT
ct-10124	35	1	in	in	ADP
ct-10124	35	2	contrast	contrast	NOUN
ct-10124	35	3	,	,	PUNCT
ct-10124	35	4	enterobacteraceae	enterobacteraceae	INTJ
ct-10124	35	5	,	,	PUNCT
ct-10124	35	6	pseudomonas	pseudomona	VERB
ct-10124	35	7	spp	spp	NOUN
ct-10124	35	8	.	.	PUNCT
ct-10124	35	9	,	,	PUNCT
ct-10124	35	10	enterococcus	enterococcus	NOUN
ct-10124	35	11	spp	spp	NOUN
ct-10124	35	12	.	.	PUNCT
ct-10124	36	1	and	and	CCONJ
ct-10124	36	2	staphylococcus	staphylococcus	NOUN
ct-10124	36	3	spp	spp	NOUN
ct-10124	36	4	.	.	PUNCT
ct-10124	36	5	have	have	VERB
ct-10124	36	6	unpredictable	unpredictable	ADJ
ct-10124	36	7	susceptibility	susceptibility	NOUN
ct-10124	36	8	profiles	profile	NOUN
ct-10124	36	9	.	.	PUNCT
ct-10124	37	1	in	in	ADP
ct-10124	37	2	vitro	vitro	X
ct-10124	37	3	susceptibility	susceptibility	NOUN
ct-10124	37	4	testing	testing	NOUN
ct-10124	37	5	is	be	AUX
ct-10124	37	6	particularly	particularly	ADV
ct-10124	37	7	important	important	ADJ
ct-10124	37	8	for	for	ADP
ct-10124	37	9	these	these	DET
ct-10124	37	10	bacterial	bacterial	ADJ
ct-10124	37	11	species	specie	NOUN
ct-10124	37	12	.	.	PUNCT
ct-10124	38	1	causes	cause	NOUN
ct-10124	38	2	of	of	ADP
ct-10124	38	3	treatment	treatment	NOUN
ct-10124	38	4	failure	failure	NOUN
ct-10124	38	5	therapeutic	therapeutic	ADJ
ct-10124	38	6	failure	failure	NOUN
ct-10124	38	7	may	may	AUX
ct-10124	38	8	occur	occur	VERB
ct-10124	38	9	when	when	SCONJ
ct-10124	38	10	the	the	DET
ct-10124	38	11	disease	disease	NOUN
ct-10124	38	12	process	process	NOUN
ct-10124	38	13	does	do	AUX
ct-10124	38	14	not	not	PART
ct-10124	38	15	have	have	VERB
ct-10124	38	16	a	a	DET
ct-10124	38	17	bacterial	bacterial	ADJ
ct-10124	38	18	etiology	etiology	NOUN
ct-10124	38	19	,	,	PUNCT
ct-10124	38	20	when	when	SCONJ
ct-10124	38	21	there	there	PRON
ct-10124	38	22	is	be	VERB
ct-10124	38	23	a	a	DET
ct-10124	38	24	change	change	NOUN
ct-10124	38	25	in	in	ADP
ct-10124	38	26	the	the	DET
ct-10124	38	27	bacterial	bacterial	ADJ
ct-10124	38	28	population	population	NOUN
ct-10124	38	29	at	at	ADP
ct-10124	38	30	the	the	DET
ct-10124	38	31	site	site	NOUN
ct-10124	38	32	of	of	ADP
ct-10124	38	33	infection	infection	NOUN
ct-10124	38	34	,	,	PUNCT
ct-10124	38	35	or	or	CCONJ
ct-10124	38	36	when	when	SCONJ
ct-10124	38	37	the	the	DET
ct-10124	38	38	pathogens	pathogen	NOUN
ct-10124	38	39	have	have	AUX
ct-10124	38	40	become	become	VERB
ct-10124	38	41	resistant	resistant	ADJ
ct-10124	38	42	to	to	ADP
ct-10124	38	43	the	the	DET
ct-10124	38	44	chosen	choose	VERB
ct-10124	38	45	antimicrobial	antimicrobial	ADJ
ct-10124	38	46	agent	agent	NOUN
ct-10124	38	47	.	.	PUNCT
ct-10124	39	1	therapeutic	therapeutic	ADJ
ct-10124	39	2	failure	failure	NOUN
ct-10124	39	3	may	may	AUX
ct-10124	39	4	also	also	ADV
ct-10124	39	5	result	result	VERB
ct-10124	39	6	from	from	ADP
ct-10124	39	7	pharmacokinetic	pharmacokinetic	ADJ
ct-10124	39	8	factors	factor	NOUN
ct-10124	39	9	that	that	PRON
ct-10124	39	10	are	be	AUX
ct-10124	39	11	often	often	ADV
ct-10124	39	12	underappreciated	underappreciate	VERB
ct-10124	39	13	by	by	ADP
ct-10124	39	14	clinicians	clinician	NOUN
ct-10124	39	15	,	,	PUNCT
ct-10124	39	16	for	for	ADP
ct-10124	39	17	example	example	NOUN
ct-10124	39	18	when	when	SCONJ
ct-10124	39	19	there	there	PRON
ct-10124	39	20	is	be	VERB
ct-10124	39	21	poor	poor	ADJ
ct-10124	39	22	diffusion	diffusion	NOUN
ct-10124	39	23	of	of	ADP
ct-10124	39	24	the	the	DET
ct-10124	39	25	drug	drug	NOUN
ct-10124	39	26	at	at	ADP
ct-10124	39	27	the	the	DET
ct-10124	39	28	site	site	NOUN
ct-10124	39	29	of	of	ADP
ct-10124	39	30	infection	infection	NOUN
ct-10124	39	31	.	.	PUNCT
ct-10124	40	1	the	the	DET
ct-10124	40	2	rate	rate	NOUN
ct-10124	40	3	and	and	CCONJ
ct-10124	40	4	extent	extent	NOUN
ct-10124	40	5	of	of	ADP
ct-10124	40	6	penetration	penetration	NOUN
ct-10124	40	7	of	of	ADP
ct-10124	40	8	a	a	DET
ct-10124	40	9	drug	drug	NOUN
ct-10124	40	10	into	into	ADP
ct-10124	40	11	most	most	ADJ
ct-10124	40	12	sites	site	NOUN
ct-10124	40	13	outside	outside	ADP
ct-10124	40	14	the	the	DET
ct-10124	40	15	vascular	vascular	ADJ
ct-10124	40	16	space	space	NOUN
ct-10124	40	17	are	be	AUX
ct-10124	40	18	determined	determine	VERB
ct-10124	40	19	by	by	ADP
ct-10124	40	20	the	the	DET
ct-10124	40	21	drug	drug	NOUN
ct-10124	40	22	’s	’s	PART
ct-10124	40	23	concentration	concentration	NOUN
ct-10124	40	24	in	in	ADP
ct-10124	40	25	plasma	plasma	NOUN
ct-10124	40	26	,	,	PUNCT
ct-10124	40	27	molecular	molecular	ADJ
ct-10124	40	28	charge	charge	NOUN
ct-10124	40	29	and	and	CCONJ
ct-10124	40	30	size	size	NOUN
ct-10124	40	31	,	,	PUNCT
ct-10124	40	32	extent	extent	NOUN
ct-10124	40	33	of	of	ADP
ct-10124	40	34	plasma	plasma	NOUN
ct-10124	40	35	protein	protein	NOUN
ct-10124	40	36	binding	bind	VERB
ct-10124	40	37	,	,	PUNCT
ct-10124	40	38	and	and	CCONJ
ct-10124	40	39	blood	blood	NOUN
ct-10124	40	40	flow	flow	NOUN
ct-10124	40	41	.	.	PUNCT
ct-10124	41	1	thus	thus	ADV
ct-10124	41	2	,	,	PUNCT
ct-10124	41	3	effective	effective	ADJ
ct-10124	41	4	antimicrobial	antimicrobial	ADJ
ct-10124	41	5	drug	drug	NOUN
ct-10124	41	6	concentrations	concentration	NOUN
ct-10124	41	7	may	may	AUX
ct-10124	41	8	not	not	PART
ct-10124	41	9	be	be	AUX
ct-10124	41	10	attained	attain	VERB
ct-10124	41	11	in	in	ADP
ct-10124	41	12	tissues	tissue	NOUN
ct-10124	41	13	that	that	PRON
ct-10124	41	14	are	be	AUX
ct-10124	41	15	poorly	poorly	ADV
ct-10124	41	16	vascularized	vascularized	ADJ
ct-10124	41	17	(	(	PUNCT
ct-10124	41	18	e.g.	e.g.	ADJ
ct-10124	41	19	,	,	PUNCT
ct-10124	41	20	abscess	abscess	NOUN
ct-10124	41	21	,	,	PUNCT
ct-10124	41	22	sequestered	sequester	VERB
ct-10124	41	23	bone	bone	NOUN
ct-10124	41	24	)	)	PUNCT
ct-10124	41	25	.	.	PUNCT
ct-10124	42	1	in	in	ADP
ct-10124	42	2	other	other	ADJ
ct-10124	42	3	tissues	tissue	NOUN
ct-10124	42	4	such	such	ADJ
ct-10124	42	5	as	as	ADP
ct-10124	42	6	the	the	DET
ct-10124	42	7	central	central	ADJ
ct-10124	42	8	nervous	nervous	ADJ
ct-10124	42	9	system	system	NOUN
ct-10124	42	10	,	,	PUNCT
ct-10124	42	11	the	the	DET
ct-10124	42	12	eye	eye	NOUN
ct-10124	42	13	,	,	PUNCT
ct-10124	42	14	and	and	CCONJ
ct-10124	42	15	the	the	DET
ct-10124	42	16	prostate	prostate	NOUN
ct-10124	42	17	,	,	PUNCT
ct-10124	42	18	a	a	DET
ct-10124	42	19	lipid	lipid	NOUN
ct-10124	42	20	membrane	membrane	NOUN
ct-10124	42	21	provides	provide	VERB
ct-10124	42	22	a	a	DET
ct-10124	42	23	barrier	barrier	NOUN
ct-10124	42	24	to	to	ADP
ct-10124	42	25	drug	drug	NOUN
ct-10124	42	26	diffusion	diffusion	NOUN
ct-10124	42	27	.	.	PUNCT
ct-10124	43	1	lipophilic	lipophilic	ADJ
ct-10124	43	2	drugs	drug	NOUN
ct-10124	43	3	such	such	ADJ
ct-10124	43	4	as	as	ADP
ct-10124	43	5	macrolides	macrolide	NOUN
ct-10124	43	6	,	,	PUNCT
ct-10124	43	7	fluoroquinolones	fluoroquinolone	NOUN
ct-10124	43	8	,	,	PUNCT
ct-10124	43	9	tetracyclines	tetracycline	NOUN
ct-10124	43	10	,	,	PUNCT
ct-10124	43	11	rifampin	rifampin	NOUN
ct-10124	43	12	,	,	PUNCT
ct-10124	43	13	trimethoprim	trimethoprim	NOUN
ct-10124	43	14	,	,	PUNCT
ct-10124	43	15	and	and	CCONJ
ct-10124	43	16	chloramphenicol	chloramphenicol	NOUN
ct-10124	43	17	are	be	AUX
ct-10124	43	18	more	more	ADV
ct-10124	43	19	likely	likely	ADJ
ct-10124	43	20	to	to	PART
ct-10124	43	21	diffuse	diffuse	VERB
ct-10124	43	22	across	across	ADP
ct-10124	43	23	lipid	lipid	NOUN
ct-10124	43	24	membranes	membrane	NOUN
ct-10124	43	25	and	and	CCONJ
ct-10124	43	26	reach	reach	VERB
ct-10124	43	27	therapeutic	therapeutic	ADJ
ct-10124	43	28	concentrations	concentration	NOUN
ct-10124	43	29	in	in	ADP
ct-10124	43	30	these	these	DET
ct-10124	43	31	tissues	tissue	NOUN
ct-10124	43	32	.	.	PUNCT
ct-10124	44	1	these	these	DET
ct-10124	44	2	drugs	drug	NOUN
ct-10124	44	3	are	be	AUX
ct-10124	44	4	also	also	ADV
ct-10124	44	5	more	more	ADV
ct-10124	44	6	likely	likely	ADJ
ct-10124	44	7	to	to	PART
ct-10124	44	8	accumulate	accumulate	VERB
ct-10124	44	9	within	within	ADP
ct-10124	44	10	cells	cell	NOUN
ct-10124	44	11	and	and	CCONJ
ct-10124	44	12	represent	represent	VERB
ct-10124	44	13	an	an	DET
ct-10124	44	14	advantage	advantage	NOUN
ct-10124	44	15	for	for	ADP
ct-10124	44	16	the	the	DET
ct-10124	44	17	treatment	treatment	NOUN
ct-10124	44	18	of	of	ADP
ct-10124	44	19	susceptible	susceptible	ADJ
ct-10124	44	20	intracellular	intracellular	ADJ
ct-10124	44	21	bacterial	bacterial	ADJ
ct-10124	44	22	pathogens	pathogen	NOUN
ct-10124	44	23	.	.	PUNCT
ct-10124	45	1	therapeutic	therapeutic	ADJ
ct-10124	45	2	failure	failure	NOUN
ct-10124	45	3	may	may	AUX
ct-10124	45	4	occur	occur	VERB
ct-10124	45	5	when	when	SCONJ
ct-10124	45	6	the	the	DET
ct-10124	45	7	microenvironment	microenvironment	NOUN
ct-10124	45	8	at	at	ADP
ct-10124	45	9	the	the	DET
ct-10124	45	10	site	site	NOUN
ct-10124	45	11	of	of	ADP
ct-10124	45	12	infection	infection	NOUN
ct-10124	45	13	is	be	AUX
ct-10124	45	14	not	not	PART
ct-10124	45	15	conductive	conductive	ADJ
ct-10124	45	16	to	to	ADP
ct-10124	45	17	antimicrobial	antimicrobial	ADJ
ct-10124	45	18	activity	activity	NOUN
ct-10124	45	19	.	.	PUNCT
ct-10124	46	1	for	for	ADP
ct-10124	46	2	example	example	NOUN
ct-10124	46	3	,	,	PUNCT
ct-10124	46	4	gentamicin	gentamicin	PROPN
ct-10124	46	5	requires	require	VERB
ct-10124	46	6	an	an	DET
ct-10124	46	7	oxidative	oxidative	ADJ
ct-10124	46	8	transport	transport	NOUN
ct-10124	46	9	system	system	NOUN
ct-10124	46	10	to	to	PART
ct-10124	46	11	penetrate	penetrate	VERB
ct-10124	46	12	the	the	DET
ct-10124	46	13	bacterial	bacterial	ADJ
ct-10124	46	14	membrane	membrane	NOUN
ct-10124	46	15	.	.	PUNCT
ct-10124	47	1	therefore	therefore	ADV
ct-10124	47	2	,	,	PUNCT
ct-10124	47	3	a	a	DET
ct-10124	47	4	given	give	VERB
ct-10124	47	5	microorganism	microorganism	NOUN
ct-10124	47	6	may	may	AUX
ct-10124	47	7	be	be	AUX
ct-10124	47	8	susceptible	susceptible	ADJ
ct-10124	47	9	to	to	ADP
ct-10124	47	10	gentamicin	gentamicin	NOUN
ct-10124	47	11	in	in	ADP
ct-10124	47	12	vitro	vitro	X
ct-10124	47	13	but	but	CCONJ
ct-10124	47	14	the	the	DET
ct-10124	47	15	drug	drug	NOUN
ct-10124	47	16	may	may	AUX
ct-10124	47	17	be	be	AUX
ct-10124	47	18	ineffective	ineffective	ADJ
ct-10124	47	19	in	in	ADP
ct-10124	47	20	an	an	DET
ct-10124	47	21	anaerobic	anaerobic	NOUN
ct-10124	47	22	microenvironment	microenvironment	NOUN
ct-10124	47	23	.	.	PUNCT
ct-10124	48	1	similarly	similarly	ADV
ct-10124	48	2	,	,	PUNCT
ct-10124	48	3	the	the	DET
ct-10124	48	4	acidic	acidic	ADJ
ct-10124	48	5	environment	environment	NOUN
ct-10124	48	6	of	of	ADP
ct-10124	48	7	infected	infected	ADJ
ct-10124	48	8	tissues	tissue	NOUN
ct-10124	48	9	may	may	AUX
ct-10124	48	10	reduce	reduce	VERB
ct-10124	48	11	the	the	DET
ct-10124	48	12	efficacy	efficacy	NOUN
ct-10124	48	13	of	of	ADP
ct-10124	48	14	macrolides	macrolide	NOUN
ct-10124	48	15	,	,	PUNCT
ct-10124	48	16	fluoroquinolones	fluoroquinolone	NOUN
ct-10124	48	17	,	,	PUNCT
ct-10124	48	18	and	and	CCONJ
ct-10124	48	19	aminoglycosides	aminoglycoside	NOUN
ct-10124	48	20	.	.	PUNCT
ct-10124	49	1	thus	thus	ADV
ct-10124	49	2	,	,	PUNCT
ct-10124	49	3	the	the	DET
ct-10124	49	4	goal	goal	NOUN
ct-10124	49	5	of	of	ADP
ct-10124	49	6	antimicrobial	antimicrobial	ADJ
ct-10124	49	7	therapy	therapy	NOUN
ct-10124	49	8	is	be	AUX
ct-10124	49	9	to	to	PART
ct-10124	49	10	select	select	VERB
ct-10124	49	11	an	an	DET
ct-10124	49	12	antibiotic	antibiotic	NOUN
ct-10124	49	13	that	that	PRON
ct-10124	49	14	,	,	PUNCT
ct-10124	49	15	in	in	ADP
ct-10124	49	16	addition	addition	NOUN
ct-10124	49	17	to	to	ADP
ct-10124	49	18	518clinical	518clinical	PROPN
ct-10124	49	19	theriogenology	theriogenology	NOUN
ct-10124	49	20	•	•	NOUN
ct-10124	49	21	volume	volume	NOUN
ct-10124	49	22	5	5	NUM
ct-10124	49	23	,	,	PUNCT
ct-10124	49	24	number	number	NOUN
ct-10124	49	25	4	4	NUM
ct-10124	49	26	•	•	NOUN
ct-10124	49	27	december	december	PROPN
ct-10124	49	28	2013	2013	NUM
ct-10124	49	29	exhibiting	exhibit	VERB
ct-10124	49	30	good	good	ADJ
ct-10124	49	31	antimicrobial	antimicrobial	ADJ
ct-10124	49	32	activity	activity	NOUN
ct-10124	49	33	against	against	ADP
ct-10124	49	34	the	the	DET
ct-10124	49	35	infecting	infect	VERB
ct-10124	49	36	microorganism	microorganism	NOUN
ct-10124	49	37	,	,	PUNCT
ct-10124	49	38	will	will	AUX
ct-10124	49	39	achieve	achieve	VERB
ct-10124	49	40	therapeutic	therapeutic	ADJ
ct-10124	49	41	concentrations	concentration	NOUN
ct-10124	49	42	in	in	ADP
ct-10124	49	43	the	the	DET
ct-10124	49	44	infected	infected	ADJ
ct-10124	49	45	area	area	NOUN
ct-10124	49	46	.	.	PUNCT
ct-10124	50	1	of	of	ADP
ct-10124	50	2	course	course	ADV
ct-10124	50	3	,	,	PUNCT
ct-10124	50	4	noncompliance	noncompliance	NOUN
ct-10124	50	5	is	be	AUX
ct-10124	50	6	a	a	DET
ct-10124	50	7	major	major	ADJ
ct-10124	50	8	cause	cause	NOUN
ct-10124	50	9	of	of	ADP
ct-10124	50	10	treatment	treatment	NOUN
ct-10124	50	11	failure	failure	NOUN
ct-10124	50	12	.	.	PUNCT
ct-10124	51	1	this	this	PRON
ct-10124	51	2	is	be	AUX
ct-10124	51	3	particularly	particularly	ADV
ct-10124	51	4	true	true	ADJ
ct-10124	51	5	for	for	ADP
ct-10124	51	6	antimicrobials	antimicrobial	NOUN
ct-10124	51	7	used	use	VERB
ct-10124	51	8	in	in	ADP
ct-10124	51	9	an	an	DET
ct-10124	51	10	unapproved	unapproved	ADJ
ct-10124	51	11	manner	manner	NOUN
ct-10124	51	12	,	,	PUNCT
ct-10124	51	13	in	in	ADP
ct-10124	51	14	which	which	DET
ct-10124	51	15	case	case	NOUN
ct-10124	51	16	data	datum	NOUN
ct-10124	51	17	may	may	AUX
ct-10124	51	18	not	not	PART
ct-10124	51	19	be	be	AUX
ct-10124	51	20	available	available	ADJ
ct-10124	51	21	to	to	PART
ct-10124	51	22	determine	determine	VERB
ct-10124	51	23	an	an	DET
ct-10124	51	24	appropriate	appropriate	ADJ
ct-10124	51	25	dosage	dosage	NOUN
ct-10124	51	26	regimen	regiman	NOUN
ct-10124	51	27	.	.	PUNCT
ct-10124	52	1	nor	nor	CCONJ
ct-10124	52	2	can	can	AUX
ct-10124	52	3	compliance	compliance	NOUN
ct-10124	52	4	be	be	AUX
ct-10124	52	5	assumed	assume	VERB
ct-10124	52	6	when	when	SCONJ
ct-10124	52	7	a	a	DET
ct-10124	52	8	horse	horse	NOUN
ct-10124	52	9	owner	owner	NOUN
ct-10124	52	10	treats	treat	VERB
ct-10124	52	11	an	an	DET
ct-10124	52	12	animal	animal	NOUN
ct-10124	52	13	at	at	ADP
ct-10124	52	14	a	a	DET
ct-10124	52	15	veterinarian	veterinarian	NOUN
ct-10124	52	16	’s	’s	PART
ct-10124	52	17	direction	direction	NOUN
ct-10124	52	18	.	.	PUNCT
ct-10124	53	1	there	there	PRON
ct-10124	53	2	is	be	VERB
ct-10124	53	3	general	general	ADJ
ct-10124	53	4	consensus	consensus	NOUN
ct-10124	53	5	that	that	SCONJ
ct-10124	53	6	noncompliance	noncompliance	NOUN
ct-10124	53	7	occurs	occur	VERB
ct-10124	53	8	in	in	ADP
ct-10124	53	9	a	a	DET
ct-10124	53	10	high	high	ADJ
ct-10124	53	11	percentage	percentage	NOUN
ct-10124	53	12	of	of	ADP
ct-10124	53	13	treatment	treatment	NOUN
ct-10124	53	14	regimens	regimen	NOUN
ct-10124	53	15	in	in	ADP
ct-10124	53	16	human	human	ADJ
ct-10124	53	17	and	and	CCONJ
ct-10124	53	18	veterinary	veterinary	ADJ
ct-10124	53	19	medicine	medicine	NOUN
ct-10124	53	20	.	.	PUNCT
ct-10124	54	1	for	for	ADP
ct-10124	54	2	example	example	NOUN
ct-10124	54	3	,	,	PUNCT
ct-10124	54	4	compliance	compliance	NOUN
ct-10124	54	5	rates	rate	NOUN
ct-10124	54	6	of	of	ADP
ct-10124	54	7	44	44	NUM
ct-10124	54	8	%	%	NOUN
ct-10124	54	9	to	to	ADP
ct-10124	54	10	64	64	NUM
ct-10124	54	11	%	%	NOUN
ct-10124	54	12	for	for	ADP
ct-10124	54	13	canine	canine	ADJ
ct-10124	54	14	antimicrobial	antimicrobial	ADJ
ct-10124	54	15	treatment	treatment	NOUN
ct-10124	54	16	have	have	AUX
ct-10124	54	17	been	be	AUX
ct-10124	54	18	reported.5,6	reported.5,6	VERB
ct-10124	54	19	the	the	DET
ct-10124	54	20	reasons	reason	NOUN
ct-10124	54	21	for	for	ADP
ct-10124	54	22	noncompliance	noncompliance	NOUN
ct-10124	54	23	are	be	AUX
ct-10124	54	24	manifold	manifold	ADJ
ct-10124	54	25	,	,	PUNCT
ct-10124	54	26	and	and	CCONJ
ct-10124	54	27	range	range	VERB
ct-10124	54	28	from	from	ADP
ct-10124	54	29	fractious	fractious	ADJ
ct-10124	54	30	animals	animal	NOUN
ct-10124	54	31	to	to	ADP
ct-10124	54	32	simple	simple	ADJ
ct-10124	54	33	oversight	oversight	NOUN
ct-10124	54	34	on	on	ADP
ct-10124	54	35	the	the	DET
ct-10124	54	36	part	part	NOUN
ct-10124	54	37	of	of	ADP
ct-10124	54	38	the	the	DET
ct-10124	54	39	owner	owner	NOUN
ct-10124	54	40	.	.	PUNCT
ct-10124	55	1	minimum	minimum	ADJ
ct-10124	55	2	inhibitory	inhibitory	ADJ
ct-10124	55	3	concentration	concentration	NOUN
ct-10124	55	4	versus	versus	ADP
ct-10124	55	5	breakpoint	breakpoint	NOUN
ct-10124	55	6	–	–	PUNCT
ct-10124	55	7	what	what	PRON
ct-10124	55	8	is	be	AUX
ct-10124	55	9	the	the	DET
ct-10124	55	10	difference	difference	NOUN
ct-10124	55	11	?	?	PUNCT
ct-10124	56	1	in	in	ADP
ct-10124	56	2	vitro	vitro	X
ct-10124	56	3	bacterial	bacterial	ADJ
ct-10124	56	4	susceptibility	susceptibility	NOUN
ct-10124	56	5	is	be	AUX
ct-10124	56	6	determined	determine	VERB
ct-10124	56	7	by	by	ADP
ct-10124	56	8	disk	disk	NOUN
ct-10124	56	9	diffusion	diffusion	NOUN
ct-10124	56	10	,	,	PUNCT
ct-10124	56	11	concentration	concentration	NOUN
ct-10124	56	12	-	-	PUNCT
ct-10124	56	13	gradient	gradient	NOUN
ct-10124	56	14	,	,	PUNCT
ct-10124	56	15	or	or	CCONJ
ct-10124	56	16	dilution	dilution	NOUN
ct-10124	56	17	methodologies	methodology	NOUN
ct-10124	56	18	.	.	PUNCT
ct-10124	57	1	disk	disk	NOUN
ct-10124	57	2	diffusion	diffusion	NOUN
ct-10124	57	3	provides	provide	VERB
ct-10124	57	4	qualitative	qualitative	ADJ
ct-10124	57	5	susceptibility	susceptibility	NOUN
ct-10124	57	6	data	datum	NOUN
ct-10124	57	7	whereas	whereas	SCONJ
ct-10124	57	8	broth	broth	ADJ
ct-10124	57	9	-	-	PUNCT
ct-10124	57	10	dilution	dilution	NOUN
ct-10124	57	11	methods	method	NOUN
ct-10124	57	12	and	and	CCONJ
ct-10124	57	13	the	the	DET
ct-10124	57	14	concentration	concentration	NOUN
ct-10124	57	15	-	-	PUNCT
ct-10124	57	16	gradient	gradient	NOUN
ct-10124	57	17	test	test	NOUN
ct-10124	57	18	(	(	PUNCT
ct-10124	57	19	e	e	NOUN
ct-10124	57	20	test	test	NOUN
ct-10124	57	21	)	)	PUNCT
ct-10124	57	22	generate	generate	VERB
ct-10124	57	23	a	a	DET
ct-10124	57	24	minimum	minimum	ADJ
ct-10124	57	25	inhibitory	inhibitory	ADJ
ct-10124	57	26	concentration	concentration	NOUN
ct-10124	57	27	(	(	PUNCT
ct-10124	57	28	mic	mic	ADJ
ct-10124	57	29	)	)	PUNCT
ct-10124	57	30	expressed	express	VERB
ct-10124	57	31	quantitatively	quantitatively	ADV
ct-10124	57	32	in	in	ADP
ct-10124	57	33	µg	µg	ADV
ct-10124	57	34	/	/	SYM
ct-10124	57	35	ml	ml	NOUN
ct-10124	57	36	.	.	PUNCT
ct-10124	58	1	all	all	PRON
ct-10124	58	2	of	of	ADP
ct-10124	58	3	the	the	DET
ct-10124	58	4	tests	test	NOUN
ct-10124	58	5	assess	assess	VERB
ct-10124	58	6	inhibition	inhibition	NOUN
ct-10124	58	7	of	of	ADP
ct-10124	58	8	bacterial	bacterial	ADJ
ct-10124	58	9	growth	growth	NOUN
ct-10124	58	10	rather	rather	ADV
ct-10124	58	11	than	than	ADP
ct-10124	58	12	killing	kill	VERB
ct-10124	58	13	of	of	ADP
ct-10124	58	14	the	the	DET
ct-10124	58	15	pathogen	pathogen	NOUN
ct-10124	58	16	as	as	ADP
ct-10124	58	17	the	the	DET
ct-10124	58	18	endpoint	endpoint	NOUN
ct-10124	58	19	.	.	PUNCT
ct-10124	59	1	susceptibility	susceptibility	NOUN
ct-10124	59	2	designations	designation	NOUN
ct-10124	59	3	are	be	AUX
ct-10124	59	4	determined	determine	VERB
ct-10124	59	5	by	by	ADP
ct-10124	59	6	comparing	compare	VERB
ct-10124	59	7	the	the	DET
ct-10124	59	8	microorganism	microorganism	NOUN
ct-10124	59	9	's	's	PART
ct-10124	59	10	mic	mic	ADJ
ct-10124	59	11	(	(	PUNCT
ct-10124	59	12	or	or	CCONJ
ct-10124	59	13	zone	zone	NOUN
ct-10124	59	14	of	of	ADP
ct-10124	59	15	inhibition	inhibition	NOUN
ct-10124	59	16	if	if	SCONJ
ct-10124	59	17	the	the	DET
ct-10124	59	18	disk	disk	NOUN
ct-10124	59	19	diffusion	diffusion	NOUN
ct-10124	59	20	method	method	NOUN
ct-10124	59	21	is	be	AUX
ct-10124	59	22	used	use	VERB
ct-10124	59	23	)	)	PUNCT
ct-10124	59	24	to	to	ADP
ct-10124	59	25	clinical	clinical	ADJ
ct-10124	59	26	breakpoints	breakpoint	NOUN
ct-10124	59	27	established	establish	VERB
ct-10124	59	28	by	by	ADP
ct-10124	59	29	the	the	DET
ct-10124	59	30	clinical	clinical	ADJ
ct-10124	59	31	laboratory	laboratory	NOUN
ct-10124	59	32	standards	standards	PROPN
ct-10124	59	33	institute	institute	PROPN
ct-10124	59	34	(	(	PUNCT
ct-10124	59	35	clsi	clsi	PROPN
ct-10124	59	36	)	)	PUNCT
ct-10124	59	37	.	.	PUNCT
ct-10124	60	1	simply	simply	ADV
ct-10124	60	2	stated	state	VERB
ct-10124	60	3	,	,	PUNCT
ct-10124	60	4	an	an	DET
ct-10124	60	5	antimicrobial	antimicrobial	ADJ
ct-10124	60	6	’s	’s	PART
ct-10124	60	7	clinical	clinical	ADJ
ct-10124	60	8	breakpoint	breakpoint	NOUN
ct-10124	60	9	is	be	AUX
ct-10124	60	10	the	the	DET
ct-10124	60	11	concentration	concentration	NOUN
ct-10124	60	12	above	above	ADV
ct-10124	60	13	and	and	CCONJ
ct-10124	60	14	below	below	ADP
ct-10124	60	15	which	which	PRON
ct-10124	60	16	specific	specific	ADJ
ct-10124	60	17	bacterial	bacterial	ADJ
ct-10124	60	18	isolates	isolate	NOUN
ct-10124	60	19	are	be	AUX
ct-10124	60	20	categorized	categorize	VERB
ct-10124	60	21	as	as	ADP
ct-10124	60	22	susceptible	susceptible	ADJ
ct-10124	60	23	,	,	PUNCT
ct-10124	60	24	intermediate	intermediate	ADJ
ct-10124	60	25	,	,	PUNCT
ct-10124	60	26	or	or	CCONJ
ct-10124	60	27	resistant	resistant	ADJ
ct-10124	60	28	.	.	PUNCT
ct-10124	61	1	clinical	clinical	ADJ
ct-10124	61	2	breakpoints	breakpoint	NOUN
ct-10124	61	3	take	take	VERB
ct-10124	61	4	an	an	DET
ct-10124	61	5	antimicrobial	antimicrobial	ADJ
ct-10124	61	6	’s	’s	PART
ct-10124	61	7	mic	mic	NOUN
ct-10124	61	8	into	into	ADP
ct-10124	61	9	consideration	consideration	NOUN
ct-10124	61	10	,	,	PUNCT
ct-10124	61	11	but	but	CCONJ
ct-10124	61	12	are	be	AUX
ct-10124	61	13	based	base	VERB
ct-10124	61	14	on	on	ADP
ct-10124	61	15	additional	additional	ADJ
ct-10124	61	16	interpretive	interpretive	ADJ
ct-10124	61	17	criteria	criterion	NOUN
ct-10124	61	18	.	.	PUNCT
ct-10124	62	1	specifically	specifically	ADV
ct-10124	62	2	,	,	PUNCT
ct-10124	62	3	clinical	clinical	ADJ
ct-10124	62	4	breakpoints	breakpoint	NOUN
ct-10124	62	5	are	be	AUX
ct-10124	62	6	determined	determine	VERB
ct-10124	62	7	by	by	ADP
ct-10124	62	8	(	(	PUNCT
ct-10124	62	9	1	1	X
ct-10124	62	10	)	)	PUNCT
ct-10124	62	11	the	the	DET
ct-10124	62	12	range	range	NOUN
ct-10124	62	13	of	of	ADP
ct-10124	62	14	in	in	ADP
ct-10124	62	15	vitro	vitro	X
ct-10124	62	16	mics	mic	NOUN
ct-10124	62	17	of	of	ADP
ct-10124	62	18	an	an	DET
ct-10124	62	19	antimicrobial	antimicrobial	NOUN
ct-10124	62	20	for	for	ADP
ct-10124	62	21	representative	representative	ADJ
ct-10124	62	22	populations	population	NOUN
ct-10124	62	23	of	of	ADP
ct-10124	62	24	specific	specific	ADJ
ct-10124	62	25	bacterial	bacterial	ADJ
ct-10124	62	26	pathogens	pathogen	NOUN
ct-10124	62	27	,	,	PUNCT
ct-10124	62	28	(	(	PUNCT
ct-10124	62	29	2	2	X
ct-10124	62	30	)	)	PUNCT
ct-10124	62	31	pharmacokinetic	pharmacokinetic	ADJ
ct-10124	62	32	parameters	parameter	NOUN
ct-10124	62	33	of	of	ADP
ct-10124	62	34	the	the	DET
ct-10124	62	35	antimicrobial	antimicrobial	ADJ
ct-10124	62	36	in	in	ADP
ct-10124	62	37	target	target	NOUN
ct-10124	62	38	animal	animal	NOUN
ct-10124	62	39	species	specie	NOUN
ct-10124	62	40	(	(	PUNCT
ct-10124	62	41	e.g.	e.g.	ADV
ct-10124	62	42	,	,	PUNCT
ct-10124	62	43	drug	drug	NOUN
ct-10124	62	44	distribution	distribution	NOUN
ct-10124	62	45	at	at	ADP
ct-10124	62	46	the	the	DET
ct-10124	62	47	site	site	NOUN
ct-10124	62	48	of	of	ADP
ct-10124	62	49	infection	infection	NOUN
ct-10124	62	50	)	)	PUNCT
ct-10124	62	51	,	,	PUNCT
ct-10124	62	52	and	and	CCONJ
ct-10124	62	53	when	when	SCONJ
ct-10124	62	54	available	available	ADJ
ct-10124	62	55	,	,	PUNCT
ct-10124	62	56	(	(	PUNCT
ct-10124	62	57	3	3	X
ct-10124	62	58	)	)	PUNCT
ct-10124	62	59	results	result	NOUN
ct-10124	62	60	of	of	ADP
ct-10124	62	61	clinical	clinical	ADJ
ct-10124	62	62	trials	trial	NOUN
ct-10124	62	63	in	in	ADP
ct-10124	62	64	the	the	DET
ct-10124	62	65	target	target	NOUN
ct-10124	62	66	species	specie	NOUN
ct-10124	62	67	,	,	PUNCT
ct-10124	62	68	the	the	DET
ct-10124	62	69	ultimate	ultimate	ADJ
ct-10124	62	70	standard	standard	NOUN
ct-10124	62	71	of	of	ADP
ct-10124	62	72	efficacy	efficacy	NOUN
ct-10124	62	73	.	.	PUNCT
ct-10124	63	1	clinical	clinical	ADJ
ct-10124	63	2	breakpoints	breakpoint	NOUN
ct-10124	63	3	are	be	AUX
ct-10124	63	4	relevant	relevant	ADJ
ct-10124	63	5	for	for	ADP
ct-10124	63	6	the	the	DET
ct-10124	63	7	specific	specific	ADJ
ct-10124	63	8	bacteria	bacteria	NOUN
ct-10124	63	9	,	,	PUNCT
ct-10124	63	10	specific	specific	ADJ
ct-10124	63	11	drug	drug	NOUN
ct-10124	63	12	,	,	PUNCT
ct-10124	63	13	and	and	CCONJ
ct-10124	63	14	specific	specific	ADJ
ct-10124	63	15	organ	organ	NOUN
ct-10124	63	16	system	system	NOUN
ct-10124	63	17	infected	infect	VERB
ct-10124	63	18	only	only	ADV
ct-10124	63	19	.	.	PUNCT
ct-10124	64	1	as	as	ADP
ct-10124	64	2	an	an	DET
ct-10124	64	3	example	example	NOUN
ct-10124	64	4	,	,	PUNCT
ct-10124	64	5	the	the	DET
ct-10124	64	6	breakpoint	breakpoint	NOUN
ct-10124	64	7	for	for	ADP
ct-10124	64	8	ceftiofur	ceftiofur	NOUN
ct-10124	64	9	in	in	ADP
ct-10124	64	10	horses	horse	NOUN
ct-10124	64	11	is	be	AUX
ct-10124	64	12	only	only	ADV
ct-10124	64	13	relevant	relevant	ADJ
ct-10124	64	14	to	to	ADP
ct-10124	64	15	s.	s.	PROPN
ct-10124	64	16	zooepidemicus	zooepidemicus	PROPN
ct-10124	64	17	in	in	ADP
ct-10124	64	18	equine	equine	NOUN
ct-10124	64	19	lung	lung	NOUN
ct-10124	64	20	,	,	PUNCT
ct-10124	64	21	and	and	CCONJ
ct-10124	64	22	infections	infection	NOUN
ct-10124	64	23	in	in	ADP
ct-10124	64	24	other	other	ADJ
ct-10124	64	25	organs	organ	NOUN
ct-10124	64	26	caused	cause	VERB
ct-10124	64	27	by	by	ADP
ct-10124	64	28	aberrant	aberrant	ADJ
ct-10124	64	29	s.	s.	PROPN
ct-10124	64	30	zooepidemicus	zooepidemicus	PROPN
ct-10124	64	31	infections	infection	NOUN
ct-10124	64	32	would	would	AUX
ct-10124	64	33	not	not	PART
ct-10124	64	34	necessarily	necessarily	ADV
ct-10124	64	35	have	have	VERB
ct-10124	64	36	the	the	DET
ct-10124	64	37	same	same	ADJ
ct-10124	64	38	clinical	clinical	ADJ
ct-10124	64	39	breakpoint	breakpoint	NOUN
ct-10124	64	40	.	.	PUNCT
ct-10124	65	1	results	result	NOUN
ct-10124	65	2	of	of	ADP
ct-10124	65	3	in	in	ADP
ct-10124	65	4	vitro	vitro	X
ct-10124	65	5	susceptibility	susceptibility	NOUN
ct-10124	65	6	tests	test	NOUN
ct-10124	65	7	are	be	AUX
ct-10124	65	8	presented	present	VERB
ct-10124	65	9	to	to	ADP
ct-10124	65	10	the	the	DET
ct-10124	65	11	clinician	clinician	NOUN
ct-10124	65	12	by	by	ADP
ct-10124	65	13	designating	designate	VERB
ct-10124	65	14	the	the	DET
ct-10124	65	15	pathogen	pathogen	NOUN
ct-10124	65	16	as	as	ADP
ct-10124	65	17	susceptible	susceptible	ADJ
ct-10124	65	18	,	,	PUNCT
ct-10124	65	19	intermediate	intermediate	ADJ
ct-10124	65	20	,	,	PUNCT
ct-10124	65	21	or	or	CCONJ
ct-10124	65	22	resistant	resistant	ADJ
ct-10124	65	23	.	.	PUNCT
ct-10124	66	1	the	the	DET
ct-10124	66	2	clsi	clsi	NOUN
ct-10124	66	3	defines	define	VERB
ct-10124	66	4	the	the	DET
ct-10124	66	5	three	three	NUM
ct-10124	66	6	susceptibility	susceptibility	NOUN
ct-10124	66	7	designations	designation	NOUN
ct-10124	66	8	as	as	SCONJ
ct-10124	66	9	follows	follow	VERB
ct-10124	66	10	:	:	PUNCT
ct-10124	66	11			NOUN
ct-10124	66	12	susceptible	susceptible	ADJ
ct-10124	66	13	–	–	PUNCT
ct-10124	66	14	an	an	DET
ct-10124	66	15	infection	infection	NOUN
ct-10124	66	16	caused	cause	VERB
ct-10124	66	17	by	by	ADP
ct-10124	66	18	the	the	DET
ct-10124	66	19	specific	specific	ADJ
ct-10124	66	20	isolate	isolate	NOUN
ct-10124	66	21	can	can	AUX
ct-10124	66	22	be	be	AUX
ct-10124	66	23	effectively	effectively	ADV
ct-10124	66	24	treated	treat	VERB
ct-10124	66	25	with	with	ADP
ct-10124	66	26	the	the	DET
ct-10124	66	27	recommended	recommend	VERB
ct-10124	66	28	antimicrobial	antimicrobial	ADJ
ct-10124	66	29	and	and	CCONJ
ct-10124	66	30	dosage	dosage	NOUN
ct-10124	66	31	regimen	regiman	NOUN
ct-10124	66	32	;	;	PUNCT
ct-10124	66	33	clsi	clsi	NOUN
ct-10124	66	34	generally	generally	ADV
ct-10124	66	35	requires	require	VERB
ct-10124	66	36	clinical	clinical	ADJ
ct-10124	66	37	response	response	NOUN
ct-10124	66	38	rates	rate	NOUN
ct-10124	66	39	of	of	ADP
ct-10124	66	40	at	at	ADV
ct-10124	66	41	least	least	ADV
ct-10124	66	42	80	80	NUM
ct-10124	66	43	%	%	NOUN
ct-10124	66	44	at	at	ADP
ct-10124	66	45	a	a	DET
ct-10124	66	46	specific	specific	ADJ
ct-10124	66	47	mic	mic	NOUN
ct-10124	66	48	before	before	SCONJ
ct-10124	66	49	organisms	organism	NOUN
ct-10124	66	50	are	be	AUX
ct-10124	66	51	categorized	categorize	VERB
ct-10124	66	52	as	as	ADP
ct-10124	66	53	susceptible	susceptible	ADJ
ct-10124	66	54	.	.	PUNCT
ct-10124	67	1			PRON
ct-10124	67	2	intermediate	intermediate	ADJ
ct-10124	67	3	–	–	PUNCT
ct-10124	67	4	an	an	DET
ct-10124	67	5	infection	infection	NOUN
ct-10124	67	6	by	by	ADP
ct-10124	67	7	the	the	DET
ct-10124	67	8	isolate	isolate	NOUN
ct-10124	67	9	can	can	AUX
ct-10124	67	10	be	be	AUX
ct-10124	67	11	treated	treat	VERB
ct-10124	67	12	at	at	ADP
ct-10124	67	13	body	body	NOUN
ct-10124	67	14	sites	site	NOUN
ct-10124	67	15	where	where	SCONJ
ct-10124	67	16	drugs	drug	NOUN
ct-10124	67	17	are	be	AUX
ct-10124	67	18	physiologically	physiologically	ADV
ct-10124	67	19	concentrated	concentrated	ADJ
ct-10124	67	20	or	or	CCONJ
ct-10124	67	21	when	when	SCONJ
ct-10124	67	22	a	a	DET
ct-10124	67	23	high	high	ADJ
ct-10124	67	24	dosage	dosage	NOUN
ct-10124	67	25	can	can	AUX
ct-10124	67	26	be	be	AUX
ct-10124	67	27	used	use	VERB
ct-10124	67	28	;	;	PUNCT
ct-10124	67	29	also	also	ADV
ct-10124	67	30	indicates	indicate	VERB
ct-10124	67	31	a	a	DET
ct-10124	67	32	“	"	PUNCT
ct-10124	67	33	buffer	buffer	NOUN
ct-10124	67	34	zone	zone	NOUN
ct-10124	67	35	”	"	PUNCT
ct-10124	67	36	that	that	PRON
ct-10124	67	37	should	should	AUX
ct-10124	67	38	prevent	prevent	VERB
ct-10124	67	39	minor	minor	ADJ
ct-10124	67	40	technical	technical	ADJ
ct-10124	67	41	factors	factor	NOUN
ct-10124	67	42	from	from	ADP
ct-10124	67	43	causing	cause	VERB
ct-10124	67	44	major	major	ADJ
ct-10124	67	45	discrepancies	discrepancy	NOUN
ct-10124	67	46	in	in	ADP
ct-10124	67	47	interpretations	interpretation	NOUN
ct-10124	67	48	.	.	PUNCT
ct-10124	68	1			X
ct-10124	68	2	resistant	resistant	ADJ
ct-10124	68	3	–	–	PUNCT
ct-10124	68	4	an	an	DET
ct-10124	68	5	infecting	infecting	NOUN
ct-10124	68	6	isolate	isolate	NOUN
ct-10124	68	7	is	be	AUX
ct-10124	68	8	not	not	PART
ct-10124	68	9	inhibited	inhibit	VERB
ct-10124	68	10	by	by	ADP
ct-10124	68	11	achievable	achievable	ADJ
ct-10124	68	12	concentrations	concentration	NOUN
ct-10124	68	13	of	of	ADP
ct-10124	68	14	the	the	DET
ct-10124	68	15	drug	drug	NOUN
ct-10124	68	16	with	with	ADP
ct-10124	68	17	normal	normal	ADJ
ct-10124	68	18	dosage	dosage	NOUN
ct-10124	68	19	schedules	schedule	NOUN
ct-10124	68	20	;	;	PUNCT
ct-10124	68	21	clinical	clinical	ADJ
ct-10124	68	22	efficacy	efficacy	NOUN
ct-10124	68	23	has	have	AUX
ct-10124	68	24	not	not	PART
ct-10124	68	25	been	be	AUX
ct-10124	68	26	reliable	reliable	ADJ
ct-10124	68	27	in	in	ADP
ct-10124	68	28	treatment	treatment	NOUN
ct-10124	68	29	studies	study	NOUN
ct-10124	68	30	.	.	PUNCT
ct-10124	69	1	interpreting	interpret	VERB
ct-10124	69	2	mic	mic	ADJ
ct-10124	69	3	values	value	NOUN
ct-10124	69	4	when	when	SCONJ
ct-10124	69	5	species	species	NOUN
ct-10124	69	6	-	-	PUNCT
ct-10124	69	7	specific	specific	ADJ
ct-10124	69	8	breakpoints	breakpoint	NOUN
ct-10124	69	9	are	be	AUX
ct-10124	69	10	used	use	VERB
ct-10124	69	11	,	,	PUNCT
ct-10124	69	12	pathogens	pathogen	NOUN
ct-10124	69	13	with	with	ADP
ct-10124	69	14	an	an	DET
ct-10124	69	15	mic	mic	NOUN
ct-10124	69	16	below	below	ADP
ct-10124	69	17	an	an	DET
ct-10124	69	18	antimicrobial	antimicrobial	ADJ
ct-10124	69	19	’s	’s	PART
ct-10124	69	20	susceptibility	susceptibility	NOUN
ct-10124	69	21	breakpoint	breakpoint	PROPN
ct-10124	69	22	have	have	VERB
ct-10124	69	23	a	a	DET
ct-10124	69	24	higher	high	ADJ
ct-10124	69	25	probability	probability	NOUN
ct-10124	69	26	for	for	ADP
ct-10124	69	27	treatment	treatment	NOUN
ct-10124	69	28	success	success	NOUN
ct-10124	69	29	,	,	PUNCT
ct-10124	69	30	and	and	CCONJ
ct-10124	69	31	organisms	organism	NOUN
ct-10124	69	32	with	with	ADP
ct-10124	69	33	an	an	DET
ct-10124	69	34	mic	mic	NOUN
ct-10124	69	35	above	above	ADP
ct-10124	69	36	the	the	DET
ct-10124	69	37	resistance	resistance	NOUN
ct-10124	69	38	breakpoint	breakpoint	NOUN
ct-10124	69	39	have	have	VERB
ct-10124	69	40	a	a	DET
ct-10124	69	41	lower	low	ADJ
ct-10124	69	42	probability	probability	NOUN
ct-10124	69	43	of	of	ADP
ct-10124	69	44	treatment	treatment	NOUN
ct-10124	69	45	success	success	NOUN
ct-10124	69	46	.	.	PUNCT
ct-10124	70	1	however	however	ADV
ct-10124	70	2	,	,	PUNCT
ct-10124	70	3	there	there	PRON
ct-10124	70	4	is	be	VERB
ct-10124	70	5	no	no	DET
ct-10124	70	6	evidence	evidence	NOUN
ct-10124	70	7	that	that	SCONJ
ct-10124	70	8	efficacy	efficacy	NOUN
ct-10124	70	9	increases	increase	VERB
ct-10124	70	10	the	the	DET
ct-10124	70	11	further	far	ADV
ct-10124	70	12	the	the	DET
ct-10124	70	13	mic	mic	NOUN
ct-10124	70	14	is	be	AUX
ct-10124	70	15	below	below	ADP
ct-10124	70	16	the	the	DET
ct-10124	70	17	breakpoint	breakpoint	NOUN
ct-10124	70	18	.	.	PUNCT
ct-10124	71	1	conversely	conversely	ADV
ct-10124	71	2	,	,	PUNCT
ct-10124	71	3	it	it	PRON
ct-10124	71	4	should	should	AUX
ct-10124	71	5	be	be	AUX
ct-10124	71	6	noted	note	VERB
ct-10124	71	7	that	that	SCONJ
ct-10124	71	8	a	a	DET
ct-10124	71	9	relatively	relatively	ADV
ct-10124	71	10	high	high	ADJ
ct-10124	71	11	mic	mic	NOUN
ct-10124	71	12	in	in	ADP
ct-10124	71	13	itself	itself	PRON
ct-10124	71	14	is	be	AUX
ct-10124	71	15	not	not	PART
ct-10124	71	16	necessarily	necessarily	ADV
ct-10124	71	17	an	an	DET
ct-10124	71	18	indicator	indicator	NOUN
ct-10124	71	19	of	of	ADP
ct-10124	71	20	resistance	resistance	NOUN
ct-10124	71	21	.	.	PUNCT
ct-10124	72	1	some	some	DET
ct-10124	72	2	resistance	resistance	NOUN
ct-10124	72	3	breakpoints	breakpoint	NOUN
ct-10124	72	4	have	have	AUX
ct-10124	72	5	been	be	AUX
ct-10124	72	6	set	set	VERB
ct-10124	72	7	at	at	ADP
ct-10124	72	8	>	>	X
ct-10124	72	9	32	32	NUM
ct-10124	72	10	µg	µg	NOUN
ct-10124	72	11	/	/	SYM
ct-10124	72	12	ml	ml	NOUN
ct-10124	72	13	or	or	CCONJ
ct-10124	72	14	higher	high	ADJ
ct-10124	72	15	(	(	PUNCT
ct-10124	72	16	e.g.	e.g.	ADV
ct-10124	72	17	,	,	PUNCT
ct-10124	72	18	the	the	DET
ct-10124	72	19	resistance	resistance	NOUN
ct-10124	72	20	breakpoint	breakpoint	NOUN
ct-10124	72	21	for	for	ADP
ct-10124	72	22	pasteurella	pasteurella	PROPN
ct-10124	72	23	multocida	multocida	PROPN
ct-10124	72	24	against	against	ADP
ct-10124	72	25	tulathromycin	tulathromycin	PROPN
ct-10124	72	26	for	for	ADP
ct-10124	72	27	bovine	bovine	ADJ
ct-10124	72	28	respiratory	respiratory	ADJ
ct-10124	72	29	disease	disease	NOUN
ct-10124	72	30	is	be	AUX
ct-10124	72	31	64	64	NUM
ct-10124	72	32	µg	µg	NOUN
ct-10124	72	33	/	/	SYM
ct-10124	72	34	ml	ml	NOUN
ct-10124	72	35	)	)	PUNCT
ct-10124	72	36	.	.	PUNCT
ct-10124	73	1	for	for	ADP
ct-10124	73	2	the	the	DET
ct-10124	73	3	equine	equine	NOUN
ct-10124	73	4	practitioner	practitioner	NOUN
ct-10124	73	5	,	,	PUNCT
ct-10124	73	6	an	an	DET
ct-10124	73	7	important	important	ADJ
ct-10124	73	8	limitation	limitation	NOUN
ct-10124	73	9	in	in	ADP
ct-10124	73	10	interpreting	interpret	VERB
ct-10124	73	11	the	the	DET
ct-10124	73	12	results	result	NOUN
ct-10124	73	13	of	of	ADP
ct-10124	73	14	in	in	ADP
ct-10124	73	15	vitro	vitro	X
ct-10124	73	16	susceptibility	susceptibility	NOUN
ct-10124	73	17	data	datum	NOUN
ct-10124	73	18	is	be	AUX
ct-10124	73	19	that	that	SCONJ
ct-10124	73	20	breakpoints	breakpoint	NOUN
ct-10124	73	21	for	for	ADP
ct-10124	73	22	only	only	ADV
ct-10124	73	23	a	a	DET
ct-10124	73	24	small	small	ADJ
ct-10124	73	25	number	number	NOUN
ct-10124	73	26	of	of	ADP
ct-10124	73	27	drugs	drug	NOUN
ct-10124	73	28	(	(	PUNCT
ct-10124	73	29	ceftiofur	ceftiofur	NOUN
ct-10124	73	30	,	,	PUNCT
ct-10124	73	31	gentamicin	gentamicin	NOUN
ct-10124	73	32	,	,	PUNCT
ct-10124	73	33	ampicillin	ampicillin	PROPN
ct-10124	73	34	)	)	PUNCT
ct-10124	73	35	have	have	AUX
ct-10124	73	36	been	be	AUX
ct-10124	73	37	established	establish	VERB
ct-10124	73	38	for	for	ADP
ct-10124	73	39	specific	specific	ADJ
ct-10124	73	40	infections	infection	NOUN
ct-10124	73	41	in	in	ADP
ct-10124	73	42	horses	horse	NOUN
ct-10124	73	43	.	.	PUNCT
ct-10124	74	1	for	for	ADP
ct-10124	74	2	all	all	DET
ct-10124	74	3	other	other	ADJ
ct-10124	74	4	antimicrobials	antimicrobial	NOUN
ct-10124	74	5	,	,	PUNCT
ct-10124	74	6	the	the	DET
ct-10124	74	7	breakpoints	breakpoint	NOUN
ct-10124	74	8	have	have	VERB
ct-10124	74	9	519	519	NUM
ct-10124	74	10	clinical	clinical	ADJ
ct-10124	74	11	theriogenology	theriogenology	NOUN
ct-10124	74	12	•	•	NOUN
ct-10124	74	13	volume	volume	NOUN
ct-10124	74	14	5	5	NUM
ct-10124	74	15	,	,	PUNCT
ct-10124	74	16	number	number	NOUN
ct-10124	74	17	4	4	NUM
ct-10124	74	18	•	•	NOUN
ct-10124	74	19	december	december	PROPN
ct-10124	74	20	2013	2013	NUM
ct-10124	74	21	been	be	AUX
ct-10124	74	22	adapted	adapt	VERB
ct-10124	74	23	from	from	ADP
ct-10124	74	24	human	human	ADJ
ct-10124	74	25	or	or	CCONJ
ct-10124	74	26	other	other	ADJ
ct-10124	74	27	domestic	domestic	ADJ
ct-10124	74	28	animal	animal	NOUN
ct-10124	74	29	species	specie	NOUN
ct-10124	74	30	data	datum	NOUN
ct-10124	74	31	.	.	PUNCT
ct-10124	75	1	for	for	ADP
ct-10124	75	2	these	these	DET
ct-10124	75	3	antimicrobials	antimicrobial	NOUN
ct-10124	75	4	,	,	PUNCT
ct-10124	75	5	a	a	DET
ct-10124	75	6	result	result	NOUN
ct-10124	75	7	indicating	indicate	VERB
ct-10124	75	8	susceptibility	susceptibility	NOUN
ct-10124	75	9	is	be	AUX
ct-10124	75	10	unquestionably	unquestionably	ADV
ct-10124	75	11	preferable	preferable	ADJ
ct-10124	75	12	to	to	ADP
ct-10124	75	13	one	one	NUM
ct-10124	75	14	indicating	indicate	VERB
ct-10124	75	15	resistance	resistance	NOUN
ct-10124	75	16	.	.	PUNCT
ct-10124	76	1	however	however	ADV
ct-10124	76	2	,	,	PUNCT
ct-10124	76	3	there	there	PRON
ct-10124	76	4	are	be	VERB
ct-10124	76	5	no	no	DET
ct-10124	76	6	data	datum	NOUN
ct-10124	76	7	correlating	correlate	VERB
ct-10124	76	8	the	the	DET
ct-10124	76	9	results	result	NOUN
ct-10124	76	10	to	to	ADP
ct-10124	76	11	clinical	clinical	ADJ
ct-10124	76	12	efficacy	efficacy	NOUN
ct-10124	76	13	and	and	CCONJ
ct-10124	76	14	there	there	PRON
ct-10124	76	15	is	be	VERB
ct-10124	76	16	no	no	DET
ct-10124	76	17	guarantee	guarantee	NOUN
ct-10124	76	18	that	that	SCONJ
ct-10124	76	19	the	the	DET
ct-10124	76	20	breakpoint	breakpoint	NOUN
ct-10124	76	21	is	be	AUX
ct-10124	76	22	valid	valid	ADJ
ct-10124	76	23	for	for	ADP
ct-10124	76	24	a	a	DET
ct-10124	76	25	given	give	VERB
ct-10124	76	26	pathogen	pathogen	NOUN
ct-10124	76	27	or	or	CCONJ
ct-10124	76	28	site	site	NOUN
ct-10124	76	29	of	of	ADP
ct-10124	76	30	infection	infection	NOUN
ct-10124	76	31	in	in	ADP
ct-10124	76	32	horses	horse	NOUN
ct-10124	76	33	.	.	PUNCT
ct-10124	77	1	for	for	ADP
ct-10124	77	2	example	example	NOUN
ct-10124	77	3	,	,	PUNCT
ct-10124	77	4	the	the	DET
ct-10124	77	5	clsi	clsi	NOUN
ct-10124	77	6	breakpoint	breakpoint	NOUN
ct-10124	77	7	for	for	ADP
ct-10124	77	8	susceptibility	susceptibility	NOUN
ct-10124	77	9	to	to	PART
ct-10124	77	10	doxycycline	doxycycline	VERB
ct-10124	77	11	is	be	AUX
ct-10124	77	12	≤4	≤4	ADJ
ct-10124	77	13	µg	µg	NOUN
ct-10124	77	14	/	/	SYM
ct-10124	77	15	ml	ml	NOUN
ct-10124	77	16	based	base	VERB
ct-10124	77	17	on	on	ADP
ct-10124	77	18	human	human	ADJ
ct-10124	77	19	pharmacokinetic	pharmacokinetic	ADJ
ct-10124	77	20	and	and	CCONJ
ct-10124	77	21	clinical	clinical	ADJ
ct-10124	77	22	efficacy	efficacy	NOUN
ct-10124	77	23	data	datum	NOUN
ct-10124	77	24	.	.	PUNCT
ct-10124	78	1	administration	administration	NOUN
ct-10124	78	2	of	of	ADP
ct-10124	78	3	oral	oral	ADJ
ct-10124	78	4	doxycyline	doxycyline	NOUN
ct-10124	78	5	to	to	ADP
ct-10124	78	6	an	an	DET
ct-10124	78	7	adult	adult	NOUN
ct-10124	78	8	horse	horse	NOUN
ct-10124	78	9	at	at	ADP
ct-10124	78	10	the	the	DET
ct-10124	78	11	recommended	recommend	VERB
ct-10124	78	12	dosage	dosage	NOUN
ct-10124	78	13	of	of	ADP
ct-10124	78	14	10	10	NUM
ct-10124	78	15	mg	mg	NUM
ct-10124	78	16	/	/	SYM
ct-10124	78	17	kg	kg	PROPN
ct-10124	78	18	results	result	NOUN
ct-10124	78	19	in	in	ADP
ct-10124	78	20	peak	peak	NOUN
ct-10124	78	21	serum	serum	NOUN
ct-10124	78	22	,	,	PUNCT
ct-10124	78	23	synovial	synovial	ADJ
ct-10124	78	24	fluid	fluid	NOUN
ct-10124	78	25	and	and	CCONJ
ct-10124	78	26	peritoneal	peritoneal	ADJ
ct-10124	78	27	fluid	fluid	ADJ
ct-10124	78	28	concentrations	concentration	NOUN
ct-10124	78	29	of	of	ADP
ct-10124	78	30	approximately	approximately	ADV
ct-10124	78	31	0.5	0.5	NUM
ct-10124	78	32	µg	µg	NOUN
ct-10124	78	33	/	/	SYM
ct-10124	78	34	ml.7	ml.7	PROPN
ct-10124	78	35	a	a	DET
ct-10124	78	36	pathogen	pathogen	NOUN
ct-10124	78	37	isolated	isolate	VERB
ct-10124	78	38	from	from	ADP
ct-10124	78	39	the	the	DET
ct-10124	78	40	synovial	synovial	ADJ
ct-10124	78	41	fluid	fluid	NOUN
ct-10124	78	42	of	of	ADP
ct-10124	78	43	a	a	DET
ct-10124	78	44	horse	horse	NOUN
ct-10124	78	45	with	with	ADP
ct-10124	78	46	a	a	DET
ct-10124	78	47	mic	mic	NOUN
ct-10124	78	48	of	of	ADP
ct-10124	78	49	4	4	NUM
ct-10124	78	50	µg	µg	NOUN
ct-10124	78	51	/	/	SYM
ct-10124	78	52	ml	ml	PUNCT
ct-10124	78	53	would	would	AUX
ct-10124	78	54	be	be	AUX
ct-10124	78	55	reported	report	VERB
ct-10124	78	56	as	as	ADP
ct-10124	78	57	susceptible	susceptible	ADJ
ct-10124	78	58	even	even	ADV
ct-10124	78	59	though	though	SCONJ
ct-10124	78	60	such	such	ADJ
ct-10124	78	61	concentrations	concentration	NOUN
ct-10124	78	62	are	be	AUX
ct-10124	78	63	far	far	ADV
ct-10124	78	64	from	from	ADP
ct-10124	78	65	achievable	achievable	ADJ
ct-10124	78	66	in	in	ADP
ct-10124	78	67	horses	horse	NOUN
ct-10124	78	68	.	.	PUNCT
ct-10124	79	1	based	base	VERB
ct-10124	79	2	on	on	ADP
ct-10124	79	3	pharmacokinetic	pharmacokinetic	ADJ
ct-10124	79	4	data	datum	NOUN
ct-10124	79	5	in	in	ADP
ct-10124	79	6	horses	horse	NOUN
ct-10124	79	7	,	,	PUNCT
ct-10124	79	8	a	a	DET
ct-10124	79	9	breakpoint	breakpoint	NOUN
ct-10124	79	10	of	of	ADP
ct-10124	79	11	≤0.25	≤0.25	PROPN
ct-10124	79	12	µg	µg	VERB
ct-10124	79	13	/	/	SYM
ct-10124	79	14	ml	ml	X
ct-10124	79	15	would	would	AUX
ct-10124	79	16	be	be	AUX
ct-10124	79	17	more	more	ADV
ct-10124	79	18	appropriate	appropriate	ADJ
ct-10124	79	19	as	as	ADP
ct-10124	79	20	a	a	DET
ct-10124	79	21	susceptibility	susceptibility	NOUN
ct-10124	79	22	standard	standard	NOUN
ct-10124	79	23	for	for	ADP
ct-10124	79	24	doxycycline.7,8	doxycycline.7,8	NOUN
ct-10124	79	25	thus	thus	ADV
ct-10124	79	26	the	the	DET
ct-10124	79	27	lack	lack	NOUN
ct-10124	79	28	of	of	ADP
ct-10124	79	29	equineand	equineand	NOUN
ct-10124	79	30	disease	disease	NOUN
ct-10124	79	31	-	-	PUNCT
ct-10124	79	32	specific	specific	ADJ
ct-10124	79	33	interpretive	interpretive	ADJ
ct-10124	79	34	criteria	criterion	NOUN
ct-10124	79	35	is	be	AUX
ct-10124	79	36	one	one	NUM
ct-10124	79	37	factor	factor	NOUN
ct-10124	79	38	that	that	PRON
ct-10124	79	39	may	may	AUX
ct-10124	79	40	explain	explain	VERB
ct-10124	79	41	discrepancies	discrepancy	NOUN
ct-10124	79	42	between	between	ADP
ct-10124	79	43	in	in	ADP
ct-10124	79	44	vitro	vitro	X
ct-10124	79	45	susceptibility	susceptibility	NOUN
ct-10124	79	46	and	and	CCONJ
ct-10124	79	47	clinical	clinical	ADJ
ct-10124	79	48	response	response	NOUN
ct-10124	79	49	.	.	PUNCT
ct-10124	80	1	by	by	ADP
ct-10124	80	2	itself	itself	PRON
ct-10124	80	3	,	,	PUNCT
ct-10124	80	4	in	in	ADP
ct-10124	80	5	vitro	vitro	X
ct-10124	80	6	susceptibility	susceptibility	NOUN
ct-10124	80	7	of	of	ADP
ct-10124	80	8	a	a	DET
ct-10124	80	9	specific	specific	ADJ
ct-10124	80	10	pathogen	pathogen	NOUN
ct-10124	80	11	does	do	AUX
ct-10124	80	12	not	not	PART
ct-10124	80	13	guarantee	guarantee	VERB
ct-10124	80	14	clinical	clinical	ADJ
ct-10124	80	15	outcome	outcome	NOUN
ct-10124	80	16	.	.	PUNCT
ct-10124	81	1	other	other	ADJ
ct-10124	81	2	factors	factor	NOUN
ct-10124	81	3	,	,	PUNCT
ct-10124	81	4	such	such	ADJ
ct-10124	81	5	as	as	ADP
ct-10124	81	6	the	the	DET
ct-10124	81	7	host	host	NOUN
ct-10124	81	8	animal	animal	NOUN
ct-10124	81	9	’s	’s	PART
ct-10124	81	10	age	age	NOUN
ct-10124	81	11	,	,	PUNCT
ct-10124	81	12	immune	immune	ADJ
ct-10124	81	13	status	status	NOUN
ct-10124	81	14	,	,	PUNCT
ct-10124	81	15	and	and	CCONJ
ct-10124	81	16	presence	presence	NOUN
ct-10124	81	17	of	of	ADP
ct-10124	81	18	mixed	mixed	ADJ
ct-10124	81	19	infections	infection	NOUN
ct-10124	81	20	can	can	AUX
ct-10124	81	21	contribute	contribute	VERB
ct-10124	81	22	to	to	ADP
ct-10124	81	23	individual	individual	ADJ
ct-10124	81	24	clinical	clinical	ADJ
ct-10124	81	25	response	response	NOUN
ct-10124	81	26	.	.	PUNCT
ct-10124	82	1	pharmacokinetic	pharmacokinetic	ADJ
ct-10124	82	2	-	-	PUNCT
ct-10124	82	3	pharmacodynamic	pharmacodynamic	ADJ
ct-10124	82	4	data	datum	NOUN
ct-10124	82	5	determine	determine	VERB
ct-10124	82	6	optimal	optimal	ADJ
ct-10124	82	7	dosage	dosage	NOUN
ct-10124	82	8	determination	determination	NOUN
ct-10124	82	9	of	of	ADP
ct-10124	82	10	the	the	DET
ct-10124	82	11	appropriate	appropriate	ADJ
ct-10124	82	12	dose	dose	NOUN
ct-10124	82	13	and	and	CCONJ
ct-10124	82	14	dosing	dosing	NOUN
ct-10124	82	15	interval	interval	NOUN
ct-10124	82	16	of	of	ADP
ct-10124	82	17	an	an	DET
ct-10124	82	18	antimicrobial	antimicrobial	ADJ
ct-10124	82	19	agent	agent	NOUN
ct-10124	82	20	requires	require	VERB
ct-10124	82	21	knowledge	knowledge	NOUN
ct-10124	82	22	and	and	CCONJ
ct-10124	82	23	integration	integration	NOUN
ct-10124	82	24	of	of	ADP
ct-10124	82	25	its	its	PRON
ct-10124	82	26	pharmacokinetics	pharmacokinetic	NOUN
ct-10124	82	27	and	and	CCONJ
ct-10124	82	28	pharmacodynamic	pharmacodynamic	ADJ
ct-10124	82	29	properties	property	NOUN
ct-10124	82	30	.	.	PUNCT
ct-10124	83	1	the	the	DET
ct-10124	83	2	pharmacokinetic	pharmacokinetic	ADJ
ct-10124	83	3	properties	property	NOUN
ct-10124	83	4	of	of	ADP
ct-10124	83	5	a	a	DET
ct-10124	83	6	drug	drug	NOUN
ct-10124	83	7	describe	describe	VERB
ct-10124	83	8	its	its	PRON
ct-10124	83	9	disposition	disposition	NOUN
ct-10124	83	10	within	within	ADP
ct-10124	83	11	the	the	DET
ct-10124	83	12	body	body	NOUN
ct-10124	83	13	and	and	CCONJ
ct-10124	83	14	include	include	VERB
ct-10124	83	15	drug	drug	NOUN
ct-10124	83	16	absorption	absorption	NOUN
ct-10124	83	17	,	,	PUNCT
ct-10124	83	18	distribution	distribution	NOUN
ct-10124	83	19	,	,	PUNCT
ct-10124	83	20	metabolism	metabolism	NOUN
ct-10124	83	21	,	,	PUNCT
ct-10124	83	22	and	and	CCONJ
ct-10124	83	23	excretion	excretion	NOUN
ct-10124	83	24	.	.	PUNCT
ct-10124	84	1	pharmacodynamic	pharmacodynamic	ADJ
ct-10124	84	2	properties	property	NOUN
ct-10124	84	3	address	address	VERB
ct-10124	84	4	the	the	DET
ct-10124	84	5	relationship	relationship	NOUN
ct-10124	84	6	between	between	ADP
ct-10124	84	7	drug	drug	NOUN
ct-10124	84	8	concentration	concentration	NOUN
ct-10124	84	9	and	and	CCONJ
ct-10124	84	10	antimicrobial	antimicrobial	ADJ
ct-10124	84	11	activity	activity	NOUN
ct-10124	84	12	.	.	PUNCT
ct-10124	85	1	drug	drug	NOUN
ct-10124	85	2	pharmacokinetic	pharmacokinetic	ADJ
ct-10124	85	3	features	feature	NOUN
ct-10124	85	4	,	,	PUNCT
ct-10124	85	5	such	such	ADJ
ct-10124	85	6	as	as	ADP
ct-10124	85	7	plasma	plasma	NOUN
ct-10124	85	8	concentrations	concentration	NOUN
ct-10124	85	9	over	over	ADP
ct-10124	85	10	time	time	NOUN
ct-10124	85	11	and	and	CCONJ
ct-10124	85	12	area	area	NOUN
ct-10124	85	13	under	under	ADP
ct-10124	85	14	the	the	DET
ct-10124	85	15	serum	serum	NOUN
ct-10124	85	16	concentration	concentration	NOUN
ct-10124	85	17	-	-	PUNCT
ct-10124	85	18	time	time	NOUN
ct-10124	85	19	curve	curve	NOUN
ct-10124	85	20	(	(	PUNCT
ct-10124	85	21	auc	auc	NOUN
ct-10124	85	22	)	)	PUNCT
ct-10124	85	23	,	,	PUNCT
ct-10124	85	24	when	when	SCONJ
ct-10124	85	25	integrated	integrate	VERB
ct-10124	85	26	with	with	ADP
ct-10124	85	27	mic	mic	ADJ
ct-10124	85	28	values	value	NOUN
ct-10124	85	29	,	,	PUNCT
ct-10124	85	30	can	can	AUX
ct-10124	85	31	predict	predict	VERB
ct-10124	85	32	the	the	DET
ct-10124	85	33	probability	probability	NOUN
ct-10124	85	34	of	of	ADP
ct-10124	85	35	bacterial	bacterial	ADJ
ct-10124	85	36	eradication	eradication	NOUN
ct-10124	85	37	and	and	CCONJ
ct-10124	85	38	clinical	clinical	ADJ
ct-10124	85	39	success	success	NOUN
ct-10124	85	40	.	.	PUNCT
ct-10124	86	1	these	these	DET
ct-10124	86	2	pharmacokinetic	pharmacokinetic	ADJ
ct-10124	86	3	and	and	CCONJ
ct-10124	86	4	pharmacodynamic	pharmacodynamic	ADJ
ct-10124	86	5	relationships	relationship	NOUN
ct-10124	86	6	may	may	AUX
ct-10124	86	7	also	also	ADV
ct-10124	86	8	play	play	VERB
ct-10124	86	9	an	an	DET
ct-10124	86	10	important	important	ADJ
ct-10124	86	11	role	role	NOUN
ct-10124	86	12	in	in	ADP
ct-10124	86	13	preventing	prevent	VERB
ct-10124	86	14	the	the	DET
ct-10124	86	15	genetic	genetic	ADJ
ct-10124	86	16	selection	selection	NOUN
ct-10124	86	17	and	and	CCONJ
ct-10124	86	18	spread	spread	VERB
ct-10124	86	19	of	of	ADP
ct-10124	86	20	resistant	resistant	ADJ
ct-10124	86	21	strains	strain	NOUN
ct-10124	86	22	.	.	PUNCT
ct-10124	87	1	the	the	DET
ct-10124	87	2	most	most	ADV
ct-10124	87	3	significant	significant	ADJ
ct-10124	87	4	factor	factor	NOUN
ct-10124	87	5	determining	determine	VERB
ct-10124	87	6	the	the	DET
ct-10124	87	7	efficacy	efficacy	NOUN
ct-10124	87	8	of	of	ADP
ct-10124	87	9	-lactams	-lactams	PROPN
ct-10124	87	10	,	,	PUNCT
ct-10124	87	11	trimethoprim	trimethoprim	ADJ
ct-10124	87	12	-	-	PUNCT
ct-10124	87	13	sulfonamide	sulfonamide	NOUN
ct-10124	87	14	combinations	combination	NOUN
ct-10124	87	15	,	,	PUNCT
ct-10124	87	16	and	and	CCONJ
ct-10124	87	17	most	most	ADV
ct-10124	87	18	bacteriostatic	bacteriostatic	ADJ
ct-10124	87	19	agents	agent	NOUN
ct-10124	87	20	such	such	ADJ
ct-10124	87	21	as	as	ADP
ct-10124	87	22	macrolides	macrolide	NOUN
ct-10124	87	23	,	,	PUNCT
ct-10124	87	24	tetracyclines	tetracycline	NOUN
ct-10124	87	25	,	,	PUNCT
ct-10124	87	26	and	and	CCONJ
ct-10124	87	27	chloramphenicol	chloramphenicol	NOUN
ct-10124	87	28	is	be	AUX
ct-10124	87	29	the	the	DET
ct-10124	87	30	length	length	NOUN
ct-10124	87	31	of	of	ADP
ct-10124	87	32	time	time	NOUN
ct-10124	87	33	that	that	PRON
ct-10124	87	34	serum	serum	NOUN
ct-10124	87	35	concentrations	concentration	NOUN
ct-10124	87	36	exceed	exceed	VERB
ct-10124	87	37	the	the	DET
ct-10124	87	38	mic	mic	NOUN
ct-10124	87	39	of	of	ADP
ct-10124	87	40	the	the	DET
ct-10124	87	41	pathogen.9	pathogen.9	NOUN
ct-10124	87	42	increasing	increase	VERB
ct-10124	87	43	the	the	DET
ct-10124	87	44	concentration	concentration	NOUN
ct-10124	87	45	of	of	ADP
ct-10124	87	46	the	the	DET
ct-10124	87	47	drug	drug	NOUN
ct-10124	87	48	several	several	ADJ
ct-10124	87	49	-	-	PUNCT
ct-10124	87	50	fold	fold	NOUN
ct-10124	87	51	above	above	ADP
ct-10124	87	52	the	the	DET
ct-10124	87	53	mic	mic	NOUN
ct-10124	87	54	does	do	AUX
ct-10124	87	55	not	not	PART
ct-10124	87	56	significantly	significantly	ADV
ct-10124	87	57	increase	increase	VERB
ct-10124	87	58	the	the	DET
ct-10124	87	59	rate	rate	NOUN
ct-10124	87	60	of	of	ADP
ct-10124	87	61	microbial	microbial	ADJ
ct-10124	87	62	killing	killing	NOUN
ct-10124	87	63	.	.	PUNCT
ct-10124	88	1	rather	rather	ADV
ct-10124	88	2	,	,	PUNCT
ct-10124	88	3	it	it	PRON
ct-10124	88	4	is	be	AUX
ct-10124	88	5	the	the	DET
ct-10124	88	6	length	length	NOUN
ct-10124	88	7	of	of	ADP
ct-10124	88	8	time	time	NOUN
ct-10124	88	9	that	that	PRON
ct-10124	88	10	bacteria	bacteria	NOUN
ct-10124	88	11	are	be	AUX
ct-10124	88	12	exposed	expose	VERB
ct-10124	88	13	to	to	ADP
ct-10124	88	14	concentrations	concentration	NOUN
ct-10124	88	15	of	of	ADP
ct-10124	88	16	these	these	DET
ct-10124	88	17	drugs	drug	NOUN
ct-10124	88	18	above	above	ADP
ct-10124	88	19	the	the	DET
ct-10124	88	20	mic	mic	NOUN
ct-10124	88	21	that	that	PRON
ct-10124	88	22	dictates	dictate	VERB
ct-10124	88	23	killing	kill	VERB
ct-10124	88	24	effect	effect	NOUN
ct-10124	88	25	.	.	PUNCT
ct-10124	89	1	therefore	therefore	ADV
ct-10124	89	2	,	,	PUNCT
ct-10124	89	3	optimal	optimal	ADJ
ct-10124	89	4	dosing	dosing	NOUN
ct-10124	89	5	of	of	ADP
ct-10124	89	6	such	such	ADJ
ct-10124	89	7	antimicrobial	antimicrobial	ADJ
ct-10124	89	8	agents	agent	NOUN
ct-10124	89	9	typically	typically	ADV
ct-10124	89	10	involves	involve	VERB
ct-10124	89	11	frequent	frequent	ADJ
ct-10124	89	12	administration	administration	NOUN
ct-10124	89	13	.	.	PUNCT
ct-10124	90	1	other	other	ADJ
ct-10124	90	2	antimicrobial	antimicrobial	ADJ
ct-10124	90	3	agents	agent	NOUN
ct-10124	90	4	such	such	ADJ
ct-10124	90	5	as	as	ADP
ct-10124	90	6	the	the	DET
ct-10124	90	7	aminoglycosides	aminoglycoside	NOUN
ct-10124	90	8	,	,	PUNCT
ct-10124	90	9	fluoroquinolones	fluoroquinolone	NOUN
ct-10124	90	10	,	,	PUNCT
ct-10124	90	11	and	and	CCONJ
ct-10124	90	12	metronidazole	metronidazole	NOUN
ct-10124	90	13	exert	exert	VERB
ct-10124	90	14	concentration	concentration	NOUN
ct-10124	90	15	-	-	PUNCT
ct-10124	90	16	dependent	dependent	ADJ
ct-10124	90	17	killing	killing	NOUN
ct-10124	90	18	characteristics	characteristic	NOUN
ct-10124	90	19	.	.	PUNCT
ct-10124	91	1	their	their	PRON
ct-10124	91	2	rate	rate	NOUN
ct-10124	91	3	of	of	ADP
ct-10124	91	4	killing	kill	VERB
ct-10124	91	5	increases	increase	NOUN
ct-10124	91	6	as	as	ADP
ct-10124	91	7	the	the	DET
ct-10124	91	8	drug	drug	NOUN
ct-10124	91	9	concentration	concentration	NOUN
ct-10124	91	10	increases	increase	NOUN
ct-10124	91	11	above	above	ADP
ct-10124	91	12	the	the	DET
ct-10124	91	13	mic	mic	NOUN
ct-10124	91	14	for	for	ADP
ct-10124	91	15	the	the	DET
ct-10124	91	16	pathogen	pathogen	NOUN
ct-10124	91	17	,	,	PUNCT
ct-10124	91	18	so	so	SCONJ
ct-10124	91	19	it	it	PRON
ct-10124	91	20	is	be	AUX
ct-10124	91	21	not	not	PART
ct-10124	91	22	necessary	necessary	ADJ
ct-10124	91	23	or	or	CCONJ
ct-10124	91	24	even	even	ADV
ct-10124	91	25	beneficial	beneficial	ADJ
ct-10124	91	26	to	to	PART
ct-10124	91	27	maintain	maintain	VERB
ct-10124	91	28	drug	drug	NOUN
ct-10124	91	29	levels	level	NOUN
ct-10124	91	30	above	above	ADP
ct-10124	91	31	the	the	DET
ct-10124	91	32	mic	mic	NOUN
ct-10124	91	33	between	between	ADP
ct-10124	91	34	doses	dose	NOUN
ct-10124	91	35	.	.	PUNCT
ct-10124	92	1	thus	thus	ADV
ct-10124	92	2	,	,	PUNCT
ct-10124	92	3	optimal	optimal	ADJ
ct-10124	92	4	dosing	dosing	NOUN
ct-10124	92	5	of	of	ADP
ct-10124	92	6	concentration	concentration	NOUN
ct-10124	92	7	-	-	PUNCT
ct-10124	92	8	dependant	dependant	ADJ
ct-10124	92	9	drugs	drug	NOUN
ct-10124	92	10	involves	involve	VERB
ct-10124	92	11	administration	administration	NOUN
ct-10124	92	12	of	of	ADP
ct-10124	92	13	high	high	ADJ
ct-10124	92	14	doses	dose	NOUN
ct-10124	92	15	with	with	ADP
ct-10124	92	16	long	long	ADJ
ct-10124	92	17	dosing	dose	VERB
ct-10124	92	18	intervals	interval	NOUN
ct-10124	92	19	.	.	PUNCT
ct-10124	93	1	with	with	ADP
ct-10124	93	2	aminoglycosides	aminoglycoside	NOUN
ct-10124	93	3	and	and	CCONJ
ct-10124	93	4	fluoroquinolones	fluoroquinolone	NOUN
ct-10124	93	5	,	,	PUNCT
ct-10124	93	6	the	the	DET
ct-10124	93	7	optimal	optimal	ADJ
ct-10124	93	8	cmax	cmax	NOUN
ct-10124	93	9	-	-	PUNCT
ct-10124	93	10	to	to	ADP
ct-10124	93	11	-	-	PUNCT
ct-10124	93	12	mic	mic	ADJ
ct-10124	93	13	ratio	ratio	NOUN
ct-10124	93	14	is	be	AUX
ct-10124	93	15	8	8	NUM
ct-10124	93	16	-	-	SYM
ct-10124	93	17	10	10	NUM
ct-10124	93	18	.	.	PUNCT
ct-10124	94	1	some	some	DET
ct-10124	94	2	drugs	drug	NOUN
ct-10124	94	3	exert	exert	VERB
ct-10124	94	4	characteristics	characteristic	NOUN
ct-10124	94	5	of	of	ADP
ct-10124	94	6	both	both	DET
ct-10124	94	7	time	time	NOUN
ct-10124	94	8	and	and	CCONJ
ct-10124	94	9	concentration	concentration	NOUN
ct-10124	94	10	dependent	dependent	ADJ
ct-10124	94	11	activity	activity	NOUN
ct-10124	94	12	.	.	PUNCT
ct-10124	95	1	the	the	DET
ct-10124	95	2	best	good	ADJ
ct-10124	95	3	predictor	predictor	NOUN
ct-10124	95	4	of	of	ADP
ct-10124	95	5	efficacy	efficacy	NOUN
ct-10124	95	6	for	for	ADP
ct-10124	95	7	these	these	DET
ct-10124	95	8	drugs	drug	NOUN
ct-10124	95	9	is	be	AUX
ct-10124	95	10	the	the	DET
ct-10124	95	11	24	24	NUM
ct-10124	95	12	-	-	PUNCT
ct-10124	95	13	hour	hour	NOUN
ct-10124	95	14	aucto	aucto	ADJ
ct-10124	95	15	-	-	PUNCT
ct-10124	95	16	mic	mic	ADJ
ct-10124	95	17	ratio	ratio	NOUN
ct-10124	95	18	.	.	PUNCT
ct-10124	96	1	glycopeptides	glycopeptide	NOUN
ct-10124	96	2	,	,	PUNCT
ct-10124	96	3	rifampin	rifampin	NOUN
ct-10124	96	4	and	and	CCONJ
ct-10124	96	5	,	,	PUNCT
ct-10124	96	6	to	to	ADP
ct-10124	96	7	some	some	DET
ct-10124	96	8	extent	extent	NOUN
ct-10124	96	9	,	,	PUNCT
ct-10124	96	10	fluoroquinolones	fluoroquinolone	NOUN
ct-10124	96	11	fall	fall	VERB
ct-10124	96	12	into	into	ADP
ct-10124	96	13	this	this	DET
ct-10124	96	14	category.10	category.10	NOUN
ct-10124	96	15	conclusion	conclusion	NOUN
ct-10124	96	16	judicious	judicious	ADJ
ct-10124	96	17	use	use	NOUN
ct-10124	96	18	of	of	ADP
ct-10124	96	19	antimicrobials	antimicrobial	NOUN
ct-10124	96	20	consists	consist	VERB
ct-10124	96	21	of	of	ADP
ct-10124	96	22	a	a	DET
ct-10124	96	23	discriminating	discriminate	VERB
ct-10124	96	24	approach	approach	NOUN
ct-10124	96	25	to	to	ADP
ct-10124	96	26	selection	selection	NOUN
ct-10124	96	27	and	and	CCONJ
ct-10124	96	28	administration	administration	NOUN
ct-10124	96	29	of	of	ADP
ct-10124	96	30	anti	anti	ADJ
ct-10124	96	31	-	-	ADJ
ct-10124	96	32	infective	infective	ADJ
ct-10124	96	33	agents	agent	NOUN
ct-10124	96	34	that	that	PRON
ct-10124	96	35	maximizes	maximize	VERB
ct-10124	96	36	treatment	treatment	NOUN
ct-10124	96	37	efficacy	efficacy	NOUN
ct-10124	96	38	while	while	SCONJ
ct-10124	96	39	minimizing	minimize	VERB
ct-10124	96	40	adverse	adverse	ADJ
ct-10124	96	41	effects	effect	NOUN
ct-10124	96	42	and	and	CCONJ
ct-10124	96	43	treatment	treatment	NOUN
ct-10124	96	44	failures	failure	NOUN
ct-10124	96	45	.	.	PUNCT
ct-10124	97	1	perhaps	perhaps	ADV
ct-10124	97	2	the	the	DET
ct-10124	97	3	most	most	ADV
ct-10124	97	4	important	important	ADJ
ct-10124	97	5	aspects	aspect	NOUN
ct-10124	97	6	of	of	ADP
ct-10124	97	7	judicious	judicious	ADJ
ct-10124	97	8	use	use	NOUN
ct-10124	97	9	are	be	AUX
ct-10124	97	10	to	to	PART
ct-10124	97	11	follow	follow	VERB
ct-10124	97	12	initial	initial	ADJ
ct-10124	97	13	empirical	empirical	ADJ
ct-10124	97	14	treatment	treatment	NOUN
ct-10124	97	15	with	with	ADP
ct-10124	97	16	culture	culture	NOUN
ct-10124	97	17	and	and	CCONJ
ct-10124	97	18	susceptibility	susceptibility	NOUN
ct-10124	97	19	testing	testing	NOUN
ct-10124	97	20	by	by	ADP
ct-10124	97	21	a	a	DET
ct-10124	97	22	diagnostic	diagnostic	ADJ
ct-10124	97	23	facility	facility	NOUN
ct-10124	97	24	that	that	PRON
ct-10124	97	25	uses	use	VERB
ct-10124	97	26	clsi	clsi	NOUN
ct-10124	97	27	standards	standard	NOUN
ct-10124	97	28	,	,	PUNCT
ct-10124	97	29	and	and	CCONJ
ct-10124	97	30	then	then	ADV
ct-10124	97	31	administer	administer	VERB
ct-10124	97	32	an	an	DET
ct-10124	97	33	antimicrobial	antimicrobial	ADJ
ct-10124	97	34	agent	agent	NOUN
ct-10124	97	35	with	with	ADP
ct-10124	97	36	an	an	DET
ct-10124	97	37	indication	indication	NOUN
ct-10124	97	38	and	and	CCONJ
ct-10124	97	39	activity	activity	NOUN
ct-10124	97	40	at	at	ADP
ct-10124	97	41	the	the	DET
ct-10124	97	42	site	site	NOUN
ct-10124	97	43	of	of	ADP
ct-10124	97	44	infection	infection	NOUN
ct-10124	97	45	against	against	ADP
ct-10124	97	46	the	the	DET
ct-10124	97	47	target	target	NOUN
ct-10124	97	48	pathogen	pathogen	NOUN
ct-10124	97	49	that	that	PRON
ct-10124	97	50	has	have	AUX
ct-10124	97	51	been	be	AUX
ct-10124	97	52	identified	identify	VERB
ct-10124	97	53	.	.	PUNCT
ct-10124	98	1	520clinical	520clinical	ADJ
ct-10124	98	2	theriogenology	theriogenology	NOUN
ct-10124	98	3	•	•	NOUN
ct-10124	98	4	volume	volume	NOUN
ct-10124	98	5	5	5	NUM
ct-10124	98	6	,	,	PUNCT
ct-10124	98	7	number	number	NOUN
ct-10124	98	8	4	4	NUM
ct-10124	98	9	•	•	NOUN
ct-10124	98	10	december	december	PROPN
ct-10124	98	11	2013	2013	NUM
ct-10124	98	12	references	reference	NOUN
ct-10124	98	13	1	1	NUM
ct-10124	98	14	.	.	PUNCT
ct-10124	98	15	morley	morley	PROPN
ct-10124	98	16	ps	ps	PROPN
ct-10124	98	17	,	,	PUNCT
ct-10124	98	18	apley	apley	PROPN
ct-10124	98	19	md	md	PROPN
ct-10124	98	20	,	,	PUNCT
ct-10124	98	21	besser	besser	PROPN
ct-10124	98	22	te	te	PROPN
ct-10124	98	23	,	,	PUNCT
ct-10124	98	24	et	et	PROPN
ct-10124	98	25	al	al	PROPN
ct-10124	98	26	:	:	PUNCT
ct-10124	98	27	antimicrobial	antimicrobial	ADJ
ct-10124	98	28	drug	drug	NOUN
ct-10124	98	29	use	use	NOUN
ct-10124	98	30	in	in	ADP
ct-10124	98	31	veterinary	veterinary	ADJ
ct-10124	98	32	medicine	medicine	NOUN
ct-10124	98	33	.	.	PUNCT
ct-10124	99	1	j	j	PROPN
ct-10124	99	2	vet	vet	NOUN
ct-10124	99	3	intern	intern	NOUN
ct-10124	99	4	med	med	ADJ
ct-10124	99	5	2005;19:617629	2005;19:617629	PROPN
ct-10124	99	6	.	.	PROPN
ct-10124	99	7	2	2	NUM
ct-10124	99	8	.	.	X
ct-10124	99	9	marsh	marsh	PROPN
ct-10124	99	10	ps	ps	PROPN
ct-10124	99	11	,	,	PUNCT
ct-10124	99	12	palmer	palmer	PROPN
ct-10124	99	13	je	je	PROPN
ct-10124	99	14	:	:	PUNCT
ct-10124	99	15	bacterial	bacterial	ADJ
ct-10124	99	16	isolates	isolate	NOUN
ct-10124	99	17	from	from	ADP
ct-10124	99	18	blood	blood	NOUN
ct-10124	99	19	and	and	CCONJ
ct-10124	99	20	their	their	PRON
ct-10124	99	21	susceptibility	susceptibility	NOUN
ct-10124	99	22	patterns	pattern	NOUN
ct-10124	99	23	in	in	ADP
ct-10124	99	24	critically	critically	ADV
ct-10124	99	25	ill	ill	ADJ
ct-10124	99	26	foals	foal	NOUN
ct-10124	99	27	:	:	PUNCT
ct-10124	99	28	543	543	NUM
ct-10124	99	29	cases	case	NOUN
ct-10124	99	30	(	(	PUNCT
ct-10124	99	31	1991	1991	NUM
ct-10124	99	32	-	-	SYM
ct-10124	99	33	1998	1998	NUM
ct-10124	99	34	)	)	PUNCT
ct-10124	99	35	.	.	PUNCT
ct-10124	100	1	j	j	PROPN
ct-10124	100	2	am	be	AUX
ct-10124	100	3	vet	vet	NOUN
ct-10124	100	4	med	med	ADJ
ct-10124	100	5	assoc	assoc	PROPN
ct-10124	100	6	2001;218:1608	2001;218:1608	PROPN
ct-10124	100	7	-	-	SYM
ct-10124	100	8	1610	1610	NUM
ct-10124	100	9	.	.	PUNCT
ct-10124	101	1	3	3	X
ct-10124	101	2	.	.	X
ct-10124	101	3	wilson	wilson	PROPN
ct-10124	101	4	wd	wd	PROPN
ct-10124	101	5	,	,	PUNCT
ct-10124	101	6	madigan	madigan	PROPN
ct-10124	101	7	je	je	PROPN
ct-10124	101	8	:	:	PUNCT
ct-10124	101	9	comparison	comparison	NOUN
ct-10124	101	10	of	of	ADP
ct-10124	101	11	bacteriologic	bacteriologic	ADJ
ct-10124	101	12	culture	culture	NOUN
ct-10124	101	13	of	of	ADP
ct-10124	101	14	blood	blood	NOUN
ct-10124	101	15	and	and	CCONJ
ct-10124	101	16	necropsy	necropsy	ADJ
ct-10124	101	17	specimens	specimen	NOUN
ct-10124	101	18	for	for	ADP
ct-10124	101	19	determining	determine	VERB
ct-10124	101	20	the	the	DET
ct-10124	101	21	cause	cause	NOUN
ct-10124	101	22	of	of	ADP
ct-10124	101	23	foal	foal	NOUN
ct-10124	101	24	septicemia	septicemia	NOUN
ct-10124	101	25	:	:	PUNCT
ct-10124	101	26	47	47	NUM
ct-10124	101	27	cases	case	NOUN
ct-10124	101	28	(	(	PUNCT
ct-10124	101	29	1978	1978	NUM
ct-10124	101	30	-	-	SYM
ct-10124	101	31	1987	1987	NUM
ct-10124	101	32	)	)	PUNCT
ct-10124	101	33	.	.	PUNCT
ct-10124	102	1	j	j	PROPN
ct-10124	102	2	am	be	AUX
ct-10124	102	3	vet	vet	NOUN
ct-10124	102	4	med	med	ADJ
ct-10124	102	5	assoc	assoc	PROPN
ct-10124	102	6	1989;195:1759	1989;195:1759	NUM
ct-10124	102	7	-	-	SYM
ct-10124	102	8	1763	1763	NUM
ct-10124	102	9	.	.	PUNCT
ct-10124	103	1	4	4	X
ct-10124	103	2	.	.	X
ct-10124	103	3	sanchez	sanchez	PROPN
ct-10124	103	4	lc	lc	PROPN
ct-10124	103	5	,	,	PUNCT
ct-10124	103	6	giguère	giguère	PROPN
ct-10124	103	7	s	s	PROPN
ct-10124	103	8	,	,	PUNCT
ct-10124	103	9	lester	lester	PROPN
ct-10124	103	10	gd	gd	PROPN
ct-10124	103	11	:	:	PUNCT
ct-10124	103	12	factors	factor	NOUN
ct-10124	103	13	associated	associate	VERB
ct-10124	103	14	with	with	ADP
ct-10124	103	15	survival	survival	NOUN
ct-10124	103	16	of	of	ADP
ct-10124	103	17	neonatal	neonatal	ADJ
ct-10124	103	18	foals	foal	NOUN
ct-10124	103	19	with	with	ADP
ct-10124	103	20	bacteremia	bacteremia	NOUN
ct-10124	103	21	and	and	CCONJ
ct-10124	103	22	racing	racing	NOUN
ct-10124	103	23	performance	performance	NOUN
ct-10124	103	24	of	of	ADP
ct-10124	103	25	surviving	survive	VERB
ct-10124	103	26	thoroughbreds	thoroughbred	NOUN
ct-10124	103	27	:	:	PUNCT
ct-10124	103	28	423	423	NUM
ct-10124	103	29	cases	case	NOUN
ct-10124	103	30	(	(	PUNCT
ct-10124	103	31	1982	1982	NUM
ct-10124	103	32	-	-	SYM
ct-10124	103	33	2007	2007	NUM
ct-10124	103	34	)	)	PUNCT
ct-10124	103	35	.	.	PUNCT
ct-10124	104	1	j	j	PROPN
ct-10124	104	2	am	be	AUX
ct-10124	104	3	vet	vet	NOUN
ct-10124	104	4	med	med	ADJ
ct-10124	104	5	assoc	assoc	PROPN
ct-10124	104	6	2008	2008	NUM
ct-10124	104	7	;	;	PUNCT
ct-10124	104	8	233:1446	233:1446	NUM
ct-10124	104	9	-	-	SYM
ct-10124	104	10	1452	1452	NUM
ct-10124	104	11	.	.	PUNCT
ct-10124	105	1	5	5	X
ct-10124	105	2	.	.	X
ct-10124	105	3	grave	grave	PROPN
ct-10124	105	4	k	k	NOUN
ct-10124	105	5	,	,	PUNCT
ct-10124	105	6	tanem	tanem	PROPN
ct-10124	105	7	h	h	NOUN
ct-10124	105	8	:	:	PUNCT
ct-10124	105	9	compliance	compliance	NOUN
ct-10124	105	10	with	with	ADP
ct-10124	105	11	short	short	ADJ
ct-10124	105	12	-	-	PUNCT
ct-10124	105	13	term	term	NOUN
ct-10124	105	14	oral	oral	ADJ
ct-10124	105	15	antibacterial	antibacterial	ADJ
ct-10124	105	16	drug	drug	NOUN
ct-10124	105	17	treatment	treatment	NOUN
ct-10124	105	18	in	in	ADP
ct-10124	105	19	dogs	dog	NOUN
ct-10124	105	20	.	.	PUNCT
ct-10124	106	1	j	j	PROPN
ct-10124	106	2	small	small	PROPN
ct-10124	106	3	anim	anim	NOUN
ct-10124	106	4	pract	pract	NOUN
ct-10124	106	5	1999;40:158	1999;40:158	PROPN
ct-10124	106	6	-	-	SYM
ct-10124	106	7	162	162	NUM
ct-10124	106	8	.	.	PUNCT
ct-10124	106	9	6	6	NUM
ct-10124	106	10	.	.	X
ct-10124	106	11	adams	adams	PROPN
ct-10124	106	12	vj	vj	PROPN
ct-10124	106	13	,	,	PUNCT
ct-10124	106	14	campbell	campbell	PROPN
ct-10124	106	15	jr	jr	PROPN
ct-10124	106	16	,	,	PUNCT
ct-10124	106	17	waldner	waldner	PROPN
ct-10124	106	18	cl	cl	PROPN
ct-10124	106	19	,	,	PUNCT
ct-10124	106	20	et	et	PROPN
ct-10124	106	21	al	al	PROPN
ct-10124	106	22	:	:	PUNCT
ct-10124	106	23	evaluation	evaluation	NOUN
ct-10124	106	24	of	of	ADP
ct-10124	106	25	client	client	NOUN
ct-10124	106	26	compliance	compliance	NOUN
ct-10124	106	27	with	with	ADP
ct-10124	106	28	short	short	ADJ
ct-10124	106	29	-	-	PUNCT
ct-10124	106	30	term	term	NOUN
ct-10124	106	31	administration	administration	NOUN
ct-10124	106	32	of	of	ADP
ct-10124	106	33	antimicrobials	antimicrobial	NOUN
ct-10124	106	34	in	in	ADP
ct-10124	106	35	dogs	dog	NOUN
ct-10124	106	36	.	.	PUNCT
ct-10124	107	1	j	j	PROPN
ct-10124	107	2	am	be	AUX
ct-10124	107	3	vet	vet	NOUN
ct-10124	107	4	med	med	ADJ
ct-10124	107	5	assoc	assoc	NOUN
ct-10124	107	6	2005;226:567	2005;226:567	NUM
ct-10124	107	7	-	-	SYM
ct-10124	107	8	574	574	NUM
ct-10124	107	9	.	.	PUNCT
ct-10124	108	1	7	7	X
ct-10124	108	2	.	.	X
ct-10124	108	3	bryant	bryant	PROPN
ct-10124	108	4	je	je	PROPN
ct-10124	108	5	,	,	PUNCT
ct-10124	108	6	brown	brown	PROPN
ct-10124	108	7	mp	mp	PROPN
ct-10124	108	8	,	,	PUNCT
ct-10124	108	9	gronwall	gronwall	PROPN
ct-10124	108	10	rr	rr	PROPN
ct-10124	108	11	,	,	PUNCT
ct-10124	108	12	et	et	PROPN
ct-10124	108	13	al	al	PROPN
ct-10124	108	14	:	:	PUNCT
ct-10124	108	15	study	study	NOUN
ct-10124	108	16	of	of	ADP
ct-10124	108	17	intragastric	intragastric	ADJ
ct-10124	108	18	administration	administration	NOUN
ct-10124	108	19	of	of	ADP
ct-10124	108	20	doxycycline	doxycycline	NOUN
ct-10124	108	21	:	:	PUNCT
ct-10124	108	22	pharmacokinetics	pharmacokinetic	NOUN
ct-10124	108	23	including	include	VERB
ct-10124	108	24	body	body	NOUN
ct-10124	108	25	fluid	fluid	NOUN
ct-10124	108	26	,	,	PUNCT
ct-10124	108	27	endometrial	endometrial	ADJ
ct-10124	108	28	and	and	CCONJ
ct-10124	108	29	minimum	minimum	ADJ
ct-10124	108	30	inhibitory	inhibitory	ADJ
ct-10124	108	31	concentrations	concentration	NOUN
ct-10124	108	32	.	.	PUNCT
ct-10124	109	1	equine	equine	NOUN
ct-10124	109	2	vet	vet	NOUN
ct-10124	109	3	j	j	PROPN
ct-10124	109	4	2000;32:233	2000;32:233	NOUN
ct-10124	109	5	-	-	NOUN
ct-10124	109	6	238	238	NUM
ct-10124	109	7	.	.	NOUN
ct-10124	109	8	8	8	NUM
ct-10124	109	9	.	.	X
ct-10124	110	1	davis	davis	PROPN
ct-10124	110	2	jl	jl	PROPN
ct-10124	110	3	,	,	PUNCT
ct-10124	110	4	salmon	salmon	PROPN
ct-10124	110	5	jh	jh	PROPN
ct-10124	110	6	,	,	PUNCT
ct-10124	110	7	papich	papich	VERB
ct-10124	110	8	mg	mg	NOUN
ct-10124	110	9	:	:	PUNCT
ct-10124	110	10	pharmacokinetics	pharmacokinetic	NOUN
ct-10124	110	11	and	and	CCONJ
ct-10124	110	12	tissue	tissue	NOUN
ct-10124	110	13	distribution	distribution	NOUN
ct-10124	110	14	of	of	ADP
ct-10124	110	15	doxycycline	doxycycline	NOUN
ct-10124	110	16	after	after	ADP
ct-10124	110	17	oral	oral	ADJ
ct-10124	110	18	administration	administration	NOUN
ct-10124	110	19	of	of	ADP
ct-10124	110	20	single	single	ADJ
ct-10124	110	21	and	and	CCONJ
ct-10124	110	22	multiple	multiple	ADJ
ct-10124	110	23	doses	dose	NOUN
ct-10124	110	24	in	in	ADP
ct-10124	110	25	horses	horse	NOUN
ct-10124	110	26	.	.	PUNCT
ct-10124	111	1	am	be	AUX
ct-10124	111	2	j	j	PROPN
ct-10124	111	3	vet	vet	NOUN
ct-10124	111	4	res	re	NOUN
ct-10124	111	5	2006;67:310	2006;67:310	PROPN
ct-10124	111	6	-	-	SYM
ct-10124	111	7	316	316	NUM
ct-10124	111	8	.	.	NOUN
ct-10124	111	9	9	9	NUM
ct-10124	111	10	.	.	PUNCT
ct-10124	111	11	andes	andes	PROPN
ct-10124	111	12	d	d	PROPN
ct-10124	111	13	,	,	PUNCT
ct-10124	111	14	anon	anon	PROPN
ct-10124	111	15	j	j	PROPN
ct-10124	111	16	,	,	PUNCT
ct-10124	111	17	jacobs	jacobs	PROPN
ct-10124	111	18	mr	mr	PROPN
ct-10124	111	19	,	,	PUNCT
ct-10124	111	20	et	et	PROPN
ct-10124	111	21	al	al	PROPN
ct-10124	111	22	:	:	PUNCT
ct-10124	111	23	application	application	NOUN
ct-10124	111	24	of	of	ADP
ct-10124	111	25	pharmacokinetics	pharmacokinetic	NOUN
ct-10124	111	26	and	and	CCONJ
ct-10124	111	27	pharmacodynamics	pharmacodynamic	NOUN
ct-10124	111	28	to	to	ADP
ct-10124	111	29	antimicrobial	antimicrobial	ADJ
ct-10124	111	30	therapy	therapy	NOUN
ct-10124	111	31	of	of	ADP
ct-10124	111	32	respiratory	respiratory	ADJ
ct-10124	111	33	tract	tract	NOUN
ct-10124	111	34	infections	infection	NOUN
ct-10124	111	35	.	.	PUNCT
ct-10124	112	1	clin	clin	PROPN
ct-10124	112	2	lab	lab	PROPN
ct-10124	112	3	med	me	VERB
ct-10124	112	4	2004;24:477	2004;24:477	NOUN
ct-10124	112	5	-	-	SYM
ct-10124	112	6	502	502	NUM
ct-10124	112	7	.	.	PUNCT
ct-10124	113	1	10	10	NUM
ct-10124	113	2	.	.	PUNCT
ct-10124	114	1	craig	craig	PROPN
ct-10124	114	2	wa	wa	PROPN
ct-10124	114	3	:	:	PUNCT
ct-10124	114	4	basic	basic	ADJ
ct-10124	114	5	pharmacodynamics	pharmacodynamic	NOUN
ct-10124	114	6	of	of	ADP
ct-10124	114	7	antibacterials	antibacterial	NOUN
ct-10124	114	8	with	with	ADP
ct-10124	114	9	clinical	clinical	ADJ
ct-10124	114	10	applications	application	NOUN
ct-10124	114	11	to	to	ADP
ct-10124	114	12	the	the	DET
ct-10124	114	13	use	use	NOUN
ct-10124	114	14	of	of	ADP
ct-10124	114	15	beta	beta	NOUN
ct-10124	114	16	-	-	PUNCT
ct-10124	114	17	lactams	lactam	NOUN
ct-10124	114	18	,	,	PUNCT
ct-10124	114	19	glycopeptides	glycopeptide	NOUN
ct-10124	114	20	,	,	PUNCT
ct-10124	114	21	and	and	CCONJ
ct-10124	114	22	linezolid	linezolid	NOUN
ct-10124	114	23	.	.	PUNCT
ct-10124	115	1	infect	infect	PROPN
ct-10124	115	2	dis	dis	PROPN
ct-10124	115	3	clin	clin	PROPN
ct-10124	115	4	north	north	PROPN
ct-10124	115	5	am	be	AUX
ct-10124	115	6	2003;17:479	2003;17:479	NOUN
ct-10124	115	7	-	-	SYM
ct-10124	115	8	501	501	NUM
ct-10124	115	9	.	.	PUNCT
ct-10124	116	1	additional	additional	ADJ
ct-10124	116	2	reading	reading	NOUN
ct-10124	116	3	papich	papich	PROPN
ct-10124	116	4	mg	mg	PROPN
ct-10124	116	5	,	,	PUNCT
ct-10124	116	6	davis	davis	PROPN
ct-10124	116	7	jl	jl	PROPN
ct-10124	116	8	:	:	PUNCT
ct-10124	116	9	antimicrobial	antimicrobial	ADJ
ct-10124	116	10	therapy	therapy	NOUN
ct-10124	116	11	.	.	PUNCT
ct-10124	117	1	in	in	ADP
ct-10124	117	2	:	:	PUNCT
ct-10124	117	3	sellon	sellon	PROPN
ct-10124	117	4	dc	dc	PROPN
ct-10124	117	5	,	,	PUNCT
ct-10124	117	6	long	long	PROPN
ct-10124	117	7	mt	mt	PROPN
ct-10124	117	8	,	,	PUNCT
ct-10124	117	9	eds	eds	PROPN
ct-10124	117	10	.	.	PUNCT
ct-10124	117	11	equine	equine	VERB
ct-10124	117	12	infectious	infectious	ADJ
ct-10124	117	13	diseases	disease	NOUN
ct-10124	117	14	.	.	PUNCT
ct-10124	118	1	st	st	PROPN
ct-10124	118	2	louis	louis	PROPN
ct-10124	118	3	:	:	PUNCT
ct-10124	118	4	saunders	saunder	NOUN
ct-10124	118	5	-	-	PUNCT
ct-10124	118	6	elsevier	elsevier	PROPN
ct-10124	118	7	;	;	PUNCT
ct-10124	118	8	2007	2007	NUM
ct-10124	118	9	.	.	PUNCT
ct-10124	119	1	p.	p.	NOUN
ct-10124	119	2	578	578	NUM
ct-10124	119	3	-	-	SYM
ct-10124	119	4	591	591	NUM
ct-10124	119	5	.	.	PUNCT
ct-10124	120	1	weese	weese	PROPN
ct-10124	120	2	s	s	PROPN
ct-10124	120	3	:	:	PUNCT
ct-10124	120	4	prudent	prudent	ADJ
ct-10124	120	5	use	use	NOUN
ct-10124	120	6	of	of	ADP
ct-10124	120	7	antimicrobials	antimicrobial	NOUN
ct-10124	120	8	.	.	PUNCT
ct-10124	121	1	in	in	ADP
ct-10124	121	2	:	:	PUNCT
ct-10124	121	3	giguère	giguère	PROPN
ct-10124	121	4	s	s	PROPN
ct-10124	121	5	,	,	PUNCT
ct-10124	121	6	prescott	prescott	PROPN
ct-10124	121	7	jf	jf	PROPN
ct-10124	121	8	,	,	PUNCT
ct-10124	121	9	baggot	baggot	VERB
ct-10124	121	10	jd	jd	PROPN
ct-10124	121	11	,	,	PUNCT
ct-10124	121	12	et	et	PROPN
ct-10124	121	13	al	al	PROPN
ct-10124	121	14	,	,	PUNCT
ct-10124	121	15	eds	eds	PROPN
ct-10124	121	16	.	.	PUNCT
ct-10124	121	17	antimicrobial	antimicrobial	ADJ
ct-10124	121	18	therapy	therapy	NOUN
ct-10124	121	19	in	in	ADP
ct-10124	121	20	veterinary	veterinary	ADJ
ct-10124	121	21	medicine	medicine	NOUN
ct-10124	121	22	,	,	PUNCT
ct-10124	121	23	4th	4th	ADJ
ct-10124	121	24	ed	ed	NOUN
ct-10124	121	25	.	.	PUNCT
ct-10124	122	1	ames(ia	ames(ia	PROPN
ct-10124	122	2	):	):	PUNCT
ct-10124	122	3	blackwell	blackwell	NOUN
ct-10124	122	4	publishing	publishing	NOUN
ct-10124	122	5	;	;	PUNCT
ct-10124	122	6	2006	2006	NUM
ct-10124	122	7	.	.	PUNCT
ct-10124	123	1	p.	p.	NOUN
ct-10124	123	2	437	437	NUM
ct-10124	123	3	-	-	SYM
ct-10124	123	4	446	446	NUM
ct-10124	123	5	.	.	PUNCT
ct-10124	124	1	wilson	wilson	PROPN
ct-10124	124	2	wd	wd	PROPN
ct-10124	124	3	:	:	PUNCT
ct-10124	124	4	rational	rational	ADJ
ct-10124	124	5	selection	selection	NOUN
ct-10124	124	6	of	of	ADP
ct-10124	124	7	antimicrobials	antimicrobial	NOUN
ct-10124	124	8	for	for	ADP
ct-10124	124	9	use	use	NOUN
ct-10124	124	10	in	in	ADP
ct-10124	124	11	horses	horse	NOUN
ct-10124	124	12	.	.	PUNCT
ct-10124	125	1	proc	proc	PROPN
ct-10124	125	2	annu	annu	PROPN
ct-10124	125	3	conv	conv	PROPN
ct-10124	125	4	am	am	PROPN
ct-10124	125	5	assoc	assoc	PROPN
ct-10124	125	6	equine	equine	PROPN
ct-10124	125	7	pract	pract	NOUN
ct-10124	125	8	;	;	PUNCT
ct-10124	125	9	2001	2001	NUM
ct-10124	125	10	.	.	PUNCT
ct-10124	126	1	p.	p.	NOUN
ct-10124	126	2	75	75	NUM
ct-10124	126	3	-	-	SYM
ct-10124	126	4	93	93	NUM
ct-10124	126	5	.	.	PUNCT
ct-10124	127	1	521	521	NUM
ct-10124	127	2	clinical	clinical	ADJ
ct-10124	127	3	theriogenology	theriogenology	NOUN
ct-10124	127	4	•	•	NOUN
ct-10124	127	5	volume	volume	NOUN
ct-10124	127	6	5	5	NUM
ct-10124	127	7	,	,	PUNCT
ct-10124	127	8	number	number	NOUN
ct-10124	127	9	4	4	NUM
ct-10124	127	10	•	•	NOUN
ct-10124	127	11	december	december	PROPN
ct-10124	127	12	2013	2013	NUM
ct-10124	127	13	522clinical	522clinical	ADJ
ct-10124	127	14	theriogenology	theriogenology	NOUN
ct-10124	127	15	•	•	NOUN
ct-10124	127	16	volume	volume	NOUN
ct-10124	127	17	5	5	NUM
ct-10124	127	18	,	,	PUNCT
ct-10124	127	19	number	number	NOUN
ct-10124	127	20	4	4	NUM
ct-10124	127	21	•	•	NOUN
ct-10124	127	22	december	december	PROPN
ct-10124	127	23	2013	2013	NUM
ct-10124	127	24	omniblank	omniblank	NOUN
ct-10124	127	25	:	:	PUNCT