id sid tid token lemma pos ct-10491 1 1 1 1 NUM ct-10491 1 2 contact contact NOUN ct-10491 1 3 sara sara PROPN ct-10491 1 4 lyle lyle PROPN ct-10491 1 5 saraklyle3@gmail.com saraklyle3@gmail.com PROPN ct-10491 1 6 ‡current ‡current NOUN ct-10491 1 7 affiliation affiliation NOUN ct-10491 1 8 : : PUNCT ct-10491 1 9 veterinary veterinary ADJ ct-10491 1 10 clinical clinical ADJ ct-10491 1 11 sciences science NOUN ct-10491 1 12 , , PUNCT ct-10491 1 13 school school NOUN ct-10491 1 14 of of ADP ct-10491 1 15 veterinary veterinary ADJ ct-10491 1 16 medicine medicine NOUN ct-10491 1 17 , , PUNCT ct-10491 1 18 louisiana louisiana PROPN ct-10491 1 19 state state PROPN ct-10491 1 20 university university PROPN ct-10491 1 21 , , PUNCT ct-10491 1 22 baton baton NOUN ct-10491 1 23 rouge rouge NOUN ct-10491 1 24 , , PUNCT ct-10491 1 25 la la PROPN ct-10491 1 26 , , PUNCT ct-10491 1 27 usa usa PROPN ct-10491 1 28 © © PROPN ct-10491 1 29 2024 2024 NUM ct-10491 1 30 the the DET ct-10491 1 31 author(s author(s NOUN ct-10491 1 32 ) ) PUNCT ct-10491 1 33 . . PUNCT ct-10491 2 1 this this PRON ct-10491 2 2 is be AUX ct-10491 2 3 an an DET ct-10491 2 4 open open ADJ ct-10491 2 5 access access NOUN ct-10491 2 6 article article NOUN ct-10491 2 7 distributed distribute VERB ct-10491 2 8 under under ADP ct-10491 2 9 the the DET ct-10491 2 10 terms term NOUN ct-10491 2 11 of of ADP ct-10491 2 12 the the DET ct-10491 2 13 creative creative ADJ ct-10491 2 14 commons common NOUN ct-10491 2 15 attribution attribution NOUN ct-10491 2 16 - - PUNCT ct-10491 2 17 noncommercial noncommercial ADJ ct-10491 2 18 4.0 4.0 NUM ct-10491 2 19 international international ADJ ct-10491 2 20 license license NOUN ct-10491 2 21 ( ( PUNCT ct-10491 2 22 http:// http:// PROPN ct-10491 2 23 creativecommons.org/licenses/by-nc/4.0/ creativecommons.org/licenses/by-nc/4.0/ NOUN ct-10491 2 24 ) ) PUNCT ct-10491 2 25 , , PUNCT ct-10491 2 26 permitting permit VERB ct-10491 2 27 all all DET ct-10491 2 28 noncommercial noncommercial ADJ ct-10491 2 29 use use NOUN ct-10491 2 30 , , PUNCT ct-10491 2 31 distribution distribution NOUN ct-10491 2 32 , , PUNCT ct-10491 2 33 and and CCONJ ct-10491 2 34 reproduction reproduction NOUN ct-10491 2 35 in in ADP ct-10491 2 36 any any DET ct-10491 2 37 medium medium NOUN ct-10491 2 38 , , PUNCT ct-10491 2 39 provided provide VERB ct-10491 2 40 the the DET ct-10491 2 41 original original ADJ ct-10491 2 42 work work NOUN ct-10491 2 43 is be AUX ct-10491 2 44 properly properly ADV ct-10491 2 45 cited cite VERB ct-10491 2 46 . . PUNCT ct-10491 3 1 citation citation NOUN ct-10491 3 2 : : PUNCT ct-10491 3 3 clinical clinical ADJ ct-10491 3 4 theriogenology theriogenology NOUN ct-10491 3 5 2024 2024 NUM ct-10491 3 6 , , PUNCT ct-10491 3 7 16 16 NUM ct-10491 3 8 , , PUNCT ct-10491 3 9 10491 10491 NUM ct-10491 3 10 , , PUNCT ct-10491 3 11 http://dx.doi.org/10.58292/ct.v16.10491 http://dx.doi.org/10.58292/ct.v16.10491 NOUN ct-10491 3 12 research research NOUN ct-10491 3 13 report report NOUN ct-10491 3 14 pharmacokinetics pharmacokinetic NOUN ct-10491 3 15 of of ADP ct-10491 3 16 carprofen carprofen NOUN ct-10491 3 17 in in ADP ct-10491 3 18 lactating lactate VERB ct-10491 3 19 dogs dog NOUN ct-10491 3 20 after after ADP ct-10491 3 21 intravenous intravenous ADJ ct-10491 3 22 treatment treatment PROPN ct-10491 3 23 amber amber PROPN ct-10491 3 24 nebel nebel PROPN ct-10491 3 25 - - PUNCT ct-10491 3 26 karp karp PROPN ct-10491 3 27 , , PUNCT ct-10491 3 28 a a DET ct-10491 3 29 mark mark NOUN ct-10491 3 30 papich papich PROPN ct-10491 3 31 , , PUNCT ct-10491 3 32 b b PROPN ct-10491 3 33 kristen kristen PROPN ct-10491 3 34 messenger messenger NOUN ct-10491 3 35 , , PUNCT ct-10491 3 36 b b PROPN ct-10491 3 37 sara sara PROPN ct-10491 3 38 lylec‡ lylec‡ DET ct-10491 3 39 aanimal aanimal ADJ ct-10491 3 40 hospital hospital NOUN ct-10491 3 41 of of ADP ct-10491 3 42 east east PROPN ct-10491 3 43 davie davie PROPN ct-10491 3 44 , , PUNCT ct-10491 3 45 advance advance PROPN ct-10491 3 46 , , PUNCT ct-10491 3 47 nc nc PROPN ct-10491 3 48 , , PUNCT ct-10491 3 49 usa usa PROPN ct-10491 3 50 bdepartment bdepartment NOUN ct-10491 3 51 of of ADP ct-10491 3 52 molecular molecular ADJ ct-10491 3 53 biomedical biomedical ADJ ct-10491 3 54 sciences science NOUN ct-10491 3 55 , , PUNCT ct-10491 3 56 college college NOUN ct-10491 3 57 of of ADP ct-10491 3 58 veterinary veterinary ADJ ct-10491 3 59 medicine medicine NOUN ct-10491 3 60 , , PUNCT ct-10491 3 61 north north PROPN ct-10491 3 62 carolina carolina PROPN ct-10491 3 63 state state PROPN ct-10491 3 64 university university PROPN ct-10491 3 65 , , PUNCT ct-10491 3 66 raleigh raleigh PROPN ct-10491 3 67 , , PUNCT ct-10491 3 68 nc nc PROPN ct-10491 3 69 , , PUNCT ct-10491 3 70 usa usa PROPN ct-10491 3 71 cdepartment cdepartment PROPN ct-10491 3 72 of of ADP ct-10491 3 73 clinical clinical ADJ ct-10491 3 74 sciences science NOUN ct-10491 3 75 , , PUNCT ct-10491 3 76 college college NOUN ct-10491 3 77 of of ADP ct-10491 3 78 veterinary veterinary ADJ ct-10491 3 79 medicine medicine NOUN ct-10491 3 80 , , PUNCT ct-10491 3 81 north north PROPN ct-10491 3 82 carolina carolina PROPN ct-10491 3 83 state state PROPN ct-10491 3 84 university university PROPN ct-10491 3 85 , , PUNCT ct-10491 3 86 raleigh raleigh PROPN ct-10491 3 87 , , PUNCT ct-10491 3 88 nc nc PROPN ct-10491 3 89 , , PUNCT ct-10491 3 90 usa usa PROPN ct-10491 3 91 abstract abstract ADJ ct-10491 3 92 analgesia analgesia PROPN ct-10491 3 93 is be AUX ct-10491 3 94 an an DET ct-10491 3 95 important important ADJ ct-10491 3 96 component component NOUN ct-10491 3 97 of of ADP ct-10491 3 98 veterinary veterinary ADJ ct-10491 3 99 care care NOUN ct-10491 3 100 with with ADP ct-10491 3 101 nonsteroidal nonsteroidal NOUN ct-10491 3 102 antiinflammatory antiinflammatory NOUN ct-10491 3 103 drugs drug NOUN ct-10491 3 104 , , PUNCT ct-10491 3 105 particularly particularly ADV ct-10491 3 106 carprofen carprofen PROPN ct-10491 3 107 ( ( PUNCT ct-10491 3 108 rimadyl rimadyl PROPN ct-10491 3 109 ® ® NOUN ct-10491 3 110 ) ) PUNCT ct-10491 3 111 commonly commonly ADV ct-10491 3 112 used use VERB ct-10491 3 113 for for ADP ct-10491 3 114 dogs dog NOUN ct-10491 3 115 . . PUNCT ct-10491 4 1 pharmacokinetic pharmacokinetic ADJ ct-10491 4 2 studies study NOUN ct-10491 4 3 of of ADP ct-10491 4 4 carprofen carprofen PROPN ct-10491 4 5 in in ADP ct-10491 4 6 lactating lactate VERB ct-10491 4 7 dogs dog NOUN ct-10491 4 8 have have AUX ct-10491 4 9 not not PART ct-10491 4 10 been be AUX ct-10491 4 11 examined examine VERB ct-10491 4 12 fully fully ADV ct-10491 4 13 , , PUNCT ct-10491 4 14 questioning question VERB ct-10491 4 15 the the DET ct-10491 4 16 use use NOUN ct-10491 4 17 and and CCONJ ct-10491 4 18 safety safety NOUN ct-10491 4 19 of of ADP ct-10491 4 20 carprofen carprofen PROPN ct-10491 4 21 . . PUNCT ct-10491 5 1 the the DET ct-10491 5 2 extent extent NOUN ct-10491 5 3 to to PART ct-10491 5 4 which which PRON ct-10491 5 5 lactation lactation NOUN ct-10491 5 6 changes change VERB ct-10491 5 7 the the DET ct-10491 5 8 pharmacokinetics pharmacokinetic NOUN ct-10491 5 9 is be AUX ct-10491 5 10 unknown unknown ADJ ct-10491 5 11 , , PUNCT ct-10491 5 12 nor nor CCONJ ct-10491 5 13 is be AUX ct-10491 5 14 the the DET ct-10491 5 15 extent extent NOUN ct-10491 5 16 of of ADP ct-10491 5 17 transfer transfer NOUN ct-10491 5 18 into into ADP ct-10491 5 19 milk milk NOUN ct-10491 5 20 of of ADP ct-10491 5 21 lactating lactate VERB ct-10491 5 22 dogs dog NOUN ct-10491 5 23 and and CCONJ ct-10491 5 24 their their PRON ct-10491 5 25 neonates neonate NOUN ct-10491 5 26 or or CCONJ ct-10491 5 27 pups pup NOUN ct-10491 5 28 . . PUNCT ct-10491 6 1 we we PRON ct-10491 6 2 hypothesized hypothesize VERB ct-10491 6 3 that that SCONJ ct-10491 6 4 after after SCONJ ct-10491 6 5 a a DET ct-10491 6 6 single single ADJ ct-10491 6 7 dose dose NOUN ct-10491 6 8 of of ADP ct-10491 6 9 intravenous intravenous ADJ ct-10491 6 10 ( ( PUNCT ct-10491 6 11 4.4 4.4 NUM ct-10491 6 12 mg mg PROPN ct-10491 6 13 / / SYM ct-10491 6 14 kg kg NOUN ct-10491 6 15 ) ) PUNCT ct-10491 6 16 to to ADP ct-10491 6 17 dogs dog NOUN ct-10491 6 18 , , PUNCT ct-10491 6 19 concentrations concentration NOUN ct-10491 6 20 in in ADP ct-10491 6 21 milk milk NOUN ct-10491 6 22 are be AUX ct-10491 6 23 low low ADJ ct-10491 6 24 and and CCONJ ct-10491 6 25 not not PART ct-10491 6 26 high high ADJ ct-10491 6 27 enough enough ADV ct-10491 6 28 to to PART ct-10491 6 29 produce produce VERB ct-10491 6 30 harmful harmful ADJ ct-10491 6 31 exposure exposure NOUN ct-10491 6 32 in in ADP ct-10491 6 33 pups pup NOUN ct-10491 6 34 . . PUNCT ct-10491 7 1 we we PRON ct-10491 7 2 tested test VERB ct-10491 7 3 our our PRON ct-10491 7 4 hypothesis hypothesis NOUN ct-10491 7 5 in in ADP ct-10491 7 6 healthy healthy ADJ ct-10491 7 7 , , PUNCT ct-10491 7 8 adult adult NOUN ct-10491 7 9 lactating lactating NOUN ct-10491 7 10 dogs dog NOUN ct-10491 7 11 ( ( PUNCT ct-10491 7 12 n n NOUN ct-10491 7 13 = = SYM ct-10491 7 14 4 4 X ct-10491 7 15 ) ) PUNCT ct-10491 7 16 using use VERB ct-10491 7 17 pharmacokinetic pharmacokinetic ADJ ct-10491 7 18 methods method NOUN ct-10491 7 19 and and CCONJ ct-10491 7 20 nonchiral nonchiral ADJ ct-10491 7 21 and and CCONJ ct-10491 7 22 chiral chiral ADJ ct-10491 7 23 specific specific ADJ ct-10491 7 24 assays assay NOUN ct-10491 7 25 measuring measure VERB ct-10491 7 26 total total NOUN ct-10491 7 27 , , PUNCT ct-10491 7 28 r- r- X ct-10491 7 29 , , PUNCT ct-10491 7 30 and and CCONJ ct-10491 7 31 s s NOUN ct-10491 7 32 - - ADJ ct-10491 7 33 enantiomer enantiomer ADJ ct-10491 7 34 carprofen carprofen NOUN ct-10491 7 35 concentrations concentration NOUN ct-10491 7 36 with with ADP ct-10491 7 37 high high ADJ ct-10491 7 38 performance performance NOUN ct-10491 7 39 liquid liquid NOUN ct-10491 7 40 chromatography chromatography NOUN ct-10491 7 41 in in ADP ct-10491 7 42 maternal maternal ADJ ct-10491 7 43 plasma plasma NOUN ct-10491 7 44 , , PUNCT ct-10491 7 45 milk milk NOUN ct-10491 7 46 , , PUNCT ct-10491 7 47 and and CCONJ ct-10491 7 48 neonatal neonatal ADJ ct-10491 7 49 plasma plasma NOUN ct-10491 7 50 samples sample NOUN ct-10491 7 51 . . PUNCT ct-10491 8 1 the the DET ct-10491 8 2 cmax cmax NOUN ct-10491 8 3 , , PUNCT ct-10491 8 4 elimination elimination NOUN ct-10491 8 5 half half ADJ ct-10491 8 6 - - PUNCT ct-10491 8 7 life life NOUN ct-10491 8 8 , , PUNCT ct-10491 8 9 and and CCONJ ct-10491 8 10 clearance clearance NOUN ct-10491 8 11 for for ADP ct-10491 8 12 maternal maternal ADJ ct-10491 8 13 plasma plasma NOUN ct-10491 8 14 were be AUX ct-10491 8 15 9.09 9.09 NUM ct-10491 8 16 and and CCONJ ct-10491 8 17 7.3 7.3 NUM ct-10491 8 18 µg µg NOUN ct-10491 8 19 / / SYM ct-10491 8 20 ml ml PROPN ct-10491 8 21 ( ( PUNCT ct-10491 8 22 r- r- X ct-10491 8 23 , , PUNCT ct-10491 8 24 s+ s+ ADV ct-10491 8 25 ) ) PUNCT ct-10491 8 26 , , PUNCT ct-10491 8 27 6.82 6.82 NUM ct-10491 8 28 and and CCONJ ct-10491 8 29 6.22 6.22 NUM ct-10491 8 30 hours hour NOUN ct-10491 8 31 ( ( PUNCT ct-10491 8 32 r- r- X ct-10491 8 33 , , PUNCT ct-10491 8 34 s+ s+ ADV ct-10491 8 35 ) ) PUNCT ct-10491 8 36 , , PUNCT ct-10491 8 37 and and CCONJ ct-10491 8 38 a a DET ct-10491 8 39 higher high ADJ ct-10491 8 40 clearance clearance NOUN ct-10491 8 41 rate rate NOUN ct-10491 8 42 of of ADP ct-10491 8 43 95.81 95.81 NUM ct-10491 8 44 ml ml NOUN ct-10491 8 45 / / SYM ct-10491 8 46 hr hr NOUN ct-10491 8 47 / / SYM ct-10491 8 48 kg kg PROPN ct-10491 8 49 ( ( PUNCT ct-10491 8 50 r- r- X ct-10491 8 51 ) ) PUNCT ct-10491 8 52 and and CCONJ ct-10491 8 53 73.87 73.87 NUM ct-10491 8 54 ml ml NOUN ct-10491 8 55 / / SYM ct-10491 8 56 hr hr NOUN ct-10491 8 57 / / SYM ct-10491 8 58 kg kg X ct-10491 8 59 ( ( PUNCT ct-10491 8 60 s+ s+ ADV ct-10491 8 61 ) ) PUNCT ct-10491 8 62 than than SCONJ ct-10491 8 63 reported report VERB ct-10491 8 64 . . PUNCT ct-10491 9 1 none none NOUN ct-10491 9 2 of of ADP ct-10491 9 3 the the DET ct-10491 9 4 neonatal neonatal ADJ ct-10491 9 5 plasma plasma NOUN ct-10491 9 6 concentrations concentration NOUN ct-10491 9 7 at at ADP ct-10491 9 8 any any DET ct-10491 9 9 time time NOUN ct-10491 9 10 point point NOUN ct-10491 9 11 were be AUX ct-10491 9 12 more more ADJ ct-10491 9 13 than than ADP ct-10491 9 14 10 10 NUM ct-10491 9 15 % % NOUN ct-10491 9 16 of of ADP ct-10491 9 17 the the DET ct-10491 9 18 total total ADJ ct-10491 9 19 maternal maternal ADJ ct-10491 9 20 plasma plasma NOUN ct-10491 9 21 concentrations concentration NOUN ct-10491 9 22 and and CCONJ ct-10491 9 23 milk milk NOUN ct-10491 9 24 : : PUNCT ct-10491 9 25 plasma plasma NOUN ct-10491 9 26 ratio ratio NOUN ct-10491 9 27 was be AUX ct-10491 9 28 < < X ct-10491 9 29 1 1 NUM ct-10491 9 30 . . PUNCT ct-10491 10 1 this this DET ct-10491 10 2 study study NOUN ct-10491 10 3 confirmed confirm VERB ct-10491 10 4 the the DET ct-10491 10 5 approved approve VERB ct-10491 10 6 dose dose NOUN ct-10491 10 7 is be AUX ct-10491 10 8 appropriate appropriate ADJ ct-10491 10 9 for for ADP ct-10491 10 10 perioperative perioperative ADJ ct-10491 10 11 and and CCONJ ct-10491 10 12 chronic chronic ADJ ct-10491 10 13 pain pain NOUN ct-10491 10 14 in in ADP ct-10491 10 15 lactating lactate VERB ct-10491 10 16 dogs dog NOUN ct-10491 10 17 and and CCONJ ct-10491 10 18 is be AUX ct-10491 10 19 safe safe ADJ ct-10491 10 20 with with ADP ct-10491 10 21 reduced reduced ADJ ct-10491 10 22 exposure exposure NOUN ct-10491 10 23 to to ADP ct-10491 10 24 nursing nursing NOUN ct-10491 10 25 pups pup NOUN ct-10491 10 26 . . PUNCT ct-10491 11 1 this this DET ct-10491 11 2 study study NOUN ct-10491 11 3 suggested suggest VERB ct-10491 11 4 that that SCONJ ct-10491 11 5 the the DET ct-10491 11 6 pharmacokinetics pharmacokinetic NOUN ct-10491 11 7 of of ADP ct-10491 11 8 carprofen carprofen NOUN ct-10491 11 9 in in ADP ct-10491 11 10 lactating lactate VERB ct-10491 11 11 dogs dog NOUN ct-10491 11 12 may may AUX ct-10491 11 13 be be AUX ct-10491 11 14 different different ADJ ct-10491 11 15 from from ADP ct-10491 11 16 their their PRON ct-10491 11 17 nonlactating nonlactate VERB ct-10491 11 18 counterparts counterpart NOUN ct-10491 11 19 . . PUNCT ct-10491 12 1 however however ADV ct-10491 12 2 , , PUNCT ct-10491 12 3 further further ADJ ct-10491 12 4 pharmacokinetic pharmacokinetic ADJ ct-10491 12 5 studies study NOUN ct-10491 12 6 with with ADP ct-10491 12 7 more more ADJ ct-10491 12 8 dogs dog NOUN ct-10491 12 9 are be AUX ct-10491 12 10 needed need VERB ct-10491 12 11 to to PART ct-10491 12 12 confirm confirm VERB ct-10491 12 13 these these DET ct-10491 12 14 findings finding NOUN ct-10491 12 15 . . PUNCT ct-10491 13 1 keywords keyword NOUN ct-10491 13 2 : : PUNCT ct-10491 13 3 lactation lactation NOUN ct-10491 13 4 , , PUNCT ct-10491 13 5 analgesia analgesia PROPN ct-10491 13 6 , , PUNCT ct-10491 13 7 carprofen carprofen PROPN ct-10491 13 8 , , PUNCT ct-10491 13 9 neonate neonate NOUN ct-10491 13 10 , , PUNCT ct-10491 13 11 pup pup ADJ ct-10491 13 12 , , PUNCT ct-10491 13 13 pharmacokinetics pharmacokinetic NOUN ct-10491 13 14 introduction introduction NOUN ct-10491 13 15 carprofen carprofen PROPN ct-10491 13 16 , , PUNCT ct-10491 13 17 a a DET ct-10491 13 18 preferential preferential ADJ ct-10491 13 19 cox-2 cox-2 NOUN ct-10491 13 20 ( ( PUNCT ct-10491 13 21 ptgs2 ptgs2 PROPN ct-10491 13 22 ; ; PUNCT ct-10491 13 23 cyclooxygenase-2 cyclooxygenase-2 NUM ct-10491 13 24 or or CCONJ ct-10491 13 25 prostaglandin prostaglandin NOUN ct-10491 13 26 - - PUNCT ct-10491 13 27 endoperoxide endoperoxide ADV ct-10491 13 28 synthase-2 synthase-2 NUM ct-10491 13 29 enzyme enzyme NOUN ct-10491 13 30 ) ) PUNCT ct-10491 13 31 inhibitor inhibitor NOUN ct-10491 13 32 first first ADV ct-10491 13 33 evaluated evaluate VERB ct-10491 13 34 in in ADP ct-10491 13 35 dogs dog NOUN ct-10491 13 36 in in ADP ct-10491 13 37 1990,1 1990,1 NUM ct-10491 13 38 is be AUX ct-10491 13 39 approved approve VERB ct-10491 13 40 for for ADP ct-10491 13 41 perioperative perioperative ADJ ct-10491 13 42 and and CCONJ ct-10491 13 43 chronic chronic ADJ ct-10491 13 44 pain pain NOUN ct-10491 13 45 management management NOUN ct-10491 13 46 in in ADP ct-10491 13 47 dogs.2 dogs.2 PROPN ct-10491 13 48 - - SYM ct-10491 13 49 5 5 NUM ct-10491 13 50 carprofen carprofen NOUN ct-10491 13 51 is be AUX ct-10491 13 52 a a DET ct-10491 13 53 racemic racemic ADJ ct-10491 13 54 nonsteroidal nonsteroidal NOUN ct-10491 13 55 antiinflammatory antiinflammatory NOUN ct-10491 13 56 drug drug NOUN ct-10491 13 57 ( ( PUNCT ct-10491 13 58 nsaid nsaid PROPN ct-10491 13 59 ) ) PUNCT ct-10491 13 60 that that PRON ct-10491 13 61 has have VERB ct-10491 13 62 antiinflammatory antiinflammatory NOUN ct-10491 13 63 , , PUNCT ct-10491 13 64 analgesic analgesic ADJ ct-10491 13 65 , , PUNCT ct-10491 13 66 and and CCONJ ct-10491 13 67 antipyretic antipyretic ADJ ct-10491 13 68 properties property NOUN ct-10491 13 69 . . PUNCT ct-10491 14 1 carprofen carprofen PROPN ct-10491 14 2 consists consist VERB ct-10491 14 3 of of ADP ct-10491 14 4 2 2 NUM ct-10491 14 5 enantiomers enantiomer NOUN ct-10491 14 6 r(- r(- PROPN ct-10491 14 7 ) ) PUNCT ct-10491 14 8 and and CCONJ ct-10491 14 9 s(+ s(+ NUM ct-10491 14 10 ) ) PUNCT ct-10491 14 11 , , PUNCT ct-10491 14 12 with with ADP ct-10491 14 13 the the DET ct-10491 14 14 s(+ s(+ PROPN ct-10491 14 15 ) ) PUNCT ct-10491 14 16 enantiomer enantiomer NOUN ct-10491 14 17 having have VERB ct-10491 14 18 greater great ADJ ct-10491 14 19 antiinflammatory antiinflammatory NOUN ct-10491 14 20 activity activity NOUN ct-10491 14 21 compared compare VERB ct-10491 14 22 to to ADP ct-10491 14 23 the the DET ct-10491 14 24 r(- r(- PROPN ct-10491 14 25 ) ) PUNCT ct-10491 14 26 enantiomer enantiomer NOUN ct-10491 14 27 . . PUNCT ct-10491 15 1 carprofen carprofen PROPN ct-10491 15 2 ordinarily ordinarily ADV ct-10491 15 3 has have VERB ct-10491 15 4 a a DET ct-10491 15 5 good good ADJ ct-10491 15 6 safety safety NOUN ct-10491 15 7 profile;3,6 profile;3,6 NOUN ct-10491 15 8 - - SYM ct-10491 15 9 8 8 NUM ct-10491 15 10 however however ADV ct-10491 15 11 , , PUNCT ct-10491 15 12 it it PRON ct-10491 15 13 has have VERB ct-10491 15 14 adverse adverse ADJ ct-10491 15 15 effects effect NOUN ct-10491 15 16 common common ADJ ct-10491 15 17 to to ADP ct-10491 15 18 all all DET ct-10491 15 19 nsaids nsaid NOUN ct-10491 15 20 , , PUNCT ct-10491 15 21 such such ADJ ct-10491 15 22 as as ADP ct-10491 15 23 kidney kidney NOUN ct-10491 15 24 , , PUNCT ct-10491 15 25 liver liver NOUN ct-10491 15 26 , , PUNCT ct-10491 15 27 and and CCONJ ct-10491 15 28 gastrointestinal gastrointestinal ADJ ct-10491 15 29 injury.1,2,6 injury.1,2,6 NOUN ct-10491 15 30 - - PROPN ct-10491 15 31 9 9 NUM ct-10491 15 32 an an DET ct-10491 15 33 adverse adverse ADJ ct-10491 15 34 reaction reaction NOUN ct-10491 15 35 specific specific ADJ ct-10491 15 36 to to ADP ct-10491 15 37 dogs dog NOUN ct-10491 15 38 is be AUX ct-10491 15 39 an an DET ct-10491 15 40 idiosyncratic idiosyncratic ADJ ct-10491 15 41 acute acute NOUN ct-10491 15 42 hepatopathy hepatopathy ADJ ct-10491 15 43 , , PUNCT ct-10491 15 44 with with ADP ct-10491 15 45 an an DET ct-10491 15 46 incidence incidence NOUN ct-10491 15 47 ranging range VERB ct-10491 15 48 from from ADP ct-10491 15 49 < < X ct-10491 15 50 0.05 0.05 NUM ct-10491 15 51 to to ADP ct-10491 15 52 1.6%.9,10 1.6%.9,10 NUM ct-10491 15 53 pharmacokinetics pharmacokinetic NOUN ct-10491 15 54 for for ADP ct-10491 15 55 carprofen carprofen NOUN ct-10491 15 56 have have AUX ct-10491 15 57 been be AUX ct-10491 15 58 reported report VERB ct-10491 15 59 in in ADP ct-10491 15 60 normal normal ADJ ct-10491 15 61 , , PUNCT ct-10491 15 62 healthy healthy ADJ ct-10491 15 63 , , PUNCT ct-10491 15 64 nonlactating nonlactate VERB ct-10491 15 65 dogs1 dogs1 NOUN ct-10491 15 66 and and CCONJ ct-10491 15 67 in in ADP ct-10491 15 68 canine canine NOUN ct-10491 15 69 induced induce VERB ct-10491 15 70 - - PUNCT ct-10491 15 71 pain pain NOUN ct-10491 15 72 models.5,9,11 models.5,9,11 NOUN ct-10491 15 73 - - PUNCT ct-10491 15 74 14 14 NUM ct-10491 15 75 following follow VERB ct-10491 15 76 cesarean cesarean ADJ ct-10491 15 77 surgery surgery NOUN ct-10491 15 78 , , PUNCT ct-10491 15 79 some some DET ct-10491 15 80 dogs dog NOUN ct-10491 15 81 experienced experience VERB ct-10491 15 82 pain pain NOUN ct-10491 15 83 or or CCONJ ct-10491 15 84 had have AUX ct-10491 15 85 preexisting preexist VERB ct-10491 15 86 problems problem NOUN ct-10491 15 87 ( ( PUNCT ct-10491 15 88 e.g. e.g. ADV ct-10491 15 89 osteoarthritis)15 osteoarthritis)15 NOUN ct-10491 15 90 that that PRON ct-10491 15 91 warranted warrant VERB ct-10491 15 92 analgesia analgesia PROPN ct-10491 15 93 . . PUNCT ct-10491 16 1 carprofen carprofen PROPN ct-10491 16 2 has have AUX ct-10491 16 3 been be AUX ct-10491 16 4 used use VERB ct-10491 16 5 anecdotally anecdotally ADV ct-10491 16 6 in in ADP ct-10491 16 7 dogs dog NOUN ct-10491 16 8 undergoing undergo VERB ct-10491 16 9 cesarean cesarean ADJ ct-10491 16 10 surgery surgery NOUN ct-10491 16 11 as as ADP ct-10491 16 12 a a DET ct-10491 16 13 single single ADJ ct-10491 16 14 subcutaneous subcutaneous ADJ ct-10491 16 15 dose dose NOUN ct-10491 16 16 without without ADP ct-10491 16 17 adverse adverse ADJ ct-10491 16 18 effects effect NOUN ct-10491 16 19 reported report VERB ct-10491 16 20 in in ADP ct-10491 16 21 either either DET ct-10491 16 22 dogs dog NOUN ct-10491 16 23 or or CCONJ ct-10491 16 24 neonates.16 neonates.16 NOUN ct-10491 16 25 - - PROPN ct-10491 16 26 18 18 NUM ct-10491 16 27 the the DET ct-10491 16 28 fda fda PROPN ct-10491 16 29 approved approve VERB ct-10491 16 30 label label NOUN ct-10491 16 31 for for ADP ct-10491 16 32 carprofen carprofen NOUN ct-10491 16 33 states state NOUN ct-10491 16 34 , , PUNCT ct-10491 16 35 “ " PUNCT ct-10491 16 36 the the DET ct-10491 16 37 safe safe ADJ ct-10491 16 38 use use NOUN ct-10491 16 39 of of ADP ct-10491 16 40 rimadyl rimadyl NOUN ct-10491 16 41 ® ® NOUN ct-10491 16 42 in in ADP ct-10491 16 43 animals animal NOUN ct-10491 16 44 less less ADJ ct-10491 16 45 than than ADP ct-10491 16 46 6 6 NUM ct-10491 16 47 weeks week NOUN ct-10491 16 48 of of ADP ct-10491 16 49 age age NOUN ct-10491 16 50 , , PUNCT ct-10491 16 51 pregnant pregnant ADJ ct-10491 16 52 dogs dog NOUN ct-10491 16 53 , , PUNCT ct-10491 16 54 dogs dog NOUN ct-10491 16 55 used use VERB ct-10491 16 56 for for ADP ct-10491 16 57 breeding breeding NOUN ct-10491 16 58 purposes purpose NOUN ct-10491 16 59 , , PUNCT ct-10491 16 60 or or CCONJ ct-10491 16 61 in in ADP ct-10491 16 62 lactating lactate VERB ct-10491 16 63 bitches bitch NOUN ct-10491 16 64 has have AUX ct-10491 16 65 not not PART ct-10491 16 66 been be AUX ct-10491 16 67 established establish VERB ct-10491 16 68 . . PUNCT ct-10491 16 69 ”9 ”9 NOUN ct-10491 17 1 this this DET ct-10491 17 2 labeling labeling NOUN ct-10491 17 3 may may AUX ct-10491 17 4 discourage discourage VERB ct-10491 17 5 effective effective ADJ ct-10491 17 6 pain pain NOUN ct-10491 17 7 treatment treatment NOUN ct-10491 17 8 and and CCONJ ct-10491 17 9 control control NOUN ct-10491 17 10 in in ADP ct-10491 17 11 dogs dog NOUN ct-10491 17 12 having having AUX ct-10491 17 13 recently recently ADV ct-10491 17 14 whelped whelp VERB ct-10491 17 15 or or CCONJ ct-10491 17 16 are be AUX ct-10491 17 17 lactating lactate VERB ct-10491 17 18 . . PUNCT ct-10491 18 1 studies study NOUN ct-10491 18 2 in in ADP ct-10491 18 3 women woman NOUN ct-10491 18 4 report report VERB ct-10491 18 5 that that SCONJ ct-10491 18 6 medications medication NOUN ct-10491 18 7 with with ADP ct-10491 18 8 greater great ADJ ct-10491 18 9 than than ADP ct-10491 18 10 85 85 NUM ct-10491 18 11 % % NOUN ct-10491 18 12 protein protein NOUN ct-10491 18 13 binding bind VERB ct-10491 18 14 produce produce VERB ct-10491 18 15 low low ADJ ct-10491 18 16 concentrations concentration NOUN ct-10491 18 17 in in ADP ct-10491 18 18 breast breast NOUN ct-10491 18 19 milk.19 milk.19 NOUN ct-10491 18 20 - - NUM ct-10491 18 21 25 25 NUM ct-10491 18 22 carprofen carprofen NOUN ct-10491 18 23 is be AUX ct-10491 18 24 99 99 NUM ct-10491 18 25 % % NOUN ct-10491 18 26 protein protein NOUN ct-10491 18 27 - - PUNCT ct-10491 18 28 bound bind VERB ct-10491 18 29 in in ADP ct-10491 18 30 canine canine NOUN ct-10491 18 31 plasma plasma NOUN ct-10491 18 32 and and CCONJ ct-10491 18 33 is be AUX ct-10491 18 34 a a DET ct-10491 18 35 weak weak ADJ ct-10491 18 36 acid acid NOUN ct-10491 18 37 ( ( PUNCT ct-10491 18 38 pka pka NOUN ct-10491 18 39 = = SYM ct-10491 18 40 4.3);1 4.3);1 NOUN ct-10491 18 41 therefore therefore ADV ct-10491 18 42 , , PUNCT ct-10491 18 43 it it PRON ct-10491 18 44 is be AUX ct-10491 18 45 less less ADV ct-10491 18 46 likely likely ADJ ct-10491 18 47 to to PART ct-10491 18 48 pass pass VERB ct-10491 18 49 from from ADP ct-10491 18 50 the the DET ct-10491 18 51 plasma plasma NOUN ct-10491 18 52 to to ADP ct-10491 18 53 milk milk NOUN ct-10491 18 54 and and CCONJ ct-10491 18 55 is be AUX ct-10491 18 56 not not PART ct-10491 18 57 a a DET ct-10491 18 58 candidate candidate NOUN ct-10491 18 59 for for ADP ct-10491 18 60 ion ion NOUN ct-10491 18 61 trapping trap VERB ct-10491 18 62 via via ADP ct-10491 18 63 the the DET ct-10491 18 64 ph ph ADJ ct-10491 18 65 - - PUNCT ct-10491 18 66 partition partition NOUN ct-10491 18 67 theory theory NOUN ct-10491 18 68 . . PUNCT ct-10491 19 1 it it PRON ct-10491 19 2 has have VERB ct-10491 19 3 a a DET ct-10491 19 4 low low ADJ ct-10491 19 5 volume volume NOUN ct-10491 19 6 of of ADP ct-10491 19 7 distribution distribution NOUN ct-10491 19 8 making make VERB ct-10491 19 9 it it PRON ct-10491 19 10 less less ADV ct-10491 19 11 likely likely ADJ ct-10491 19 12 to to PART ct-10491 19 13 diffuse diffuse VERB ct-10491 19 14 out out ADP ct-10491 19 15 of of ADP ct-10491 19 16 the the DET ct-10491 19 17 mailto:saraklyle3@gmail.com mailto:saraklyle3@gmail.com PROPN ct-10491 19 18 http://creativecommons.org/licenses/by-nc/4.0/ http://creativecommons.org/licenses/by-nc/4.0/ PROPN ct-10491 20 1 http://creativecommons.org/licenses/by-nc/4.0/ http://creativecommons.org/licenses/by-nc/4.0/ PROPN ct-10491 20 2 http://dx.doi.org/10.58292/ct.v16.10491 http://dx.doi.org/10.58292/ct.v16.10491 NOUN ct-10491 20 3 2 2 NUM ct-10491 20 4 citation citation NOUN ct-10491 20 5 : : PUNCT ct-10491 20 6 clinical clinical ADJ ct-10491 20 7 theriogenology theriogenology NOUN ct-10491 20 8 2024 2024 NUM ct-10491 20 9 , , PUNCT ct-10491 20 10 16 16 NUM ct-10491 20 11 , , PUNCT ct-10491 20 12 10491 10491 NUM ct-10491 20 13 , , PUNCT ct-10491 20 14 http://dx.doi.org/10.58292/ct.v16.10491 http://dx.doi.org/10.58292/ct.v16.10491 NOUN ct-10491 20 15 intravascular intravascular ADJ ct-10491 20 16 space space NOUN ct-10491 20 17 into into ADP ct-10491 20 18 the the DET ct-10491 20 19 body body NOUN ct-10491 20 20 tissue tissue NOUN ct-10491 20 21 , , PUNCT ct-10491 20 22 even even ADV ct-10491 20 23 in in ADP ct-10491 20 24 inflammatory inflammatory ADJ ct-10491 20 25 conditions.12,13 conditions.12,13 NOUN ct-10491 20 26 in in ADP ct-10491 20 27 a a DET ct-10491 20 28 study study NOUN ct-10491 20 29 , , PUNCT ct-10491 20 30 dogs dog NOUN ct-10491 20 31 that that PRON ct-10491 20 32 received receive VERB ct-10491 20 33 a a DET ct-10491 20 34 5 5 NUM ct-10491 20 35 - - PUNCT ct-10491 20 36 day day NOUN ct-10491 20 37 course course NOUN ct-10491 20 38 of of ADP ct-10491 20 39 carprofen carprofen NOUN ct-10491 20 40 following follow VERB ct-10491 20 41 cesarean cesarean ADJ ct-10491 20 42 surgery surgery NOUN ct-10491 20 43 were be AUX ct-10491 20 44 assigned assign VERB ct-10491 20 45 to to ADP ct-10491 20 46 3 3 NUM ct-10491 20 47 groups group NOUN ct-10491 20 48 : : PUNCT ct-10491 20 49 ‘ ' PUNCT ct-10491 20 50 normal normal ADJ ct-10491 20 51 ’ ' PUNCT ct-10491 20 52 ( ( PUNCT ct-10491 20 53 88 88 NUM ct-10491 20 54 ) ) PUNCT ct-10491 20 55 , , PUNCT ct-10491 20 56 ‘ ' PUNCT ct-10491 20 57 mastitis mastitis NOUN ct-10491 20 58 ’ ' PUNCT ct-10491 20 59 ( ( PUNCT ct-10491 20 60 4 4 NUM ct-10491 20 61 ) ) PUNCT ct-10491 20 62 , , PUNCT ct-10491 20 63 and and CCONJ ct-10491 20 64 ‘ ' PUNCT ct-10491 20 65 generalized generalized ADJ ct-10491 20 66 inflammation inflammation NOUN ct-10491 20 67 ’ ' PUNCT ct-10491 20 68 ( ( PUNCT ct-10491 20 69 8).18 8).18 NUM ct-10491 20 70 maternal maternal ADJ ct-10491 20 71 plasma plasma NOUN ct-10491 20 72 and and CCONJ ct-10491 20 73 milk milk NOUN ct-10491 20 74 sample sample NOUN ct-10491 20 75 concentrations concentration NOUN ct-10491 20 76 were be AUX ct-10491 20 77 compared compare VERB ct-10491 20 78 , , PUNCT ct-10491 20 79 and and CCONJ ct-10491 20 80 dogs dog NOUN ct-10491 20 81 with with ADP ct-10491 20 82 mastitis mastitis NOUN ct-10491 20 83 had have VERB ct-10491 20 84 higher high ADJ ct-10491 20 85 concentrations concentration NOUN ct-10491 20 86 of of ADP ct-10491 20 87 carprofen carprofen NOUN ct-10491 20 88 in in ADP ct-10491 20 89 the the DET ct-10491 20 90 milk milk NOUN ct-10491 20 91 compared compare VERB ct-10491 20 92 to to ADP ct-10491 20 93 the the DET ct-10491 20 94 normal normal ADJ ct-10491 20 95 and and CCONJ ct-10491 20 96 generalized generalized ADJ ct-10491 20 97 inflammation inflammation NOUN ct-10491 20 98 groups group NOUN ct-10491 20 99 . . PUNCT ct-10491 21 1 predicted predict VERB ct-10491 21 2 expected expect VERB ct-10491 21 3 neonatal neonatal ADJ ct-10491 21 4 exposure exposure NOUN ct-10491 21 5 was be AUX ct-10491 21 6 < < X ct-10491 21 7 1 1 NUM ct-10491 21 8 ( ( PUNCT ct-10491 21 9 milk milk NOUN ct-10491 21 10 : : PUNCT ct-10491 21 11 plasma plasma NOUN ct-10491 21 12 ratio ratio NOUN ct-10491 21 13 ) ) PUNCT ct-10491 21 14 in in ADP ct-10491 21 15 all all DET ct-10491 21 16 groups.18 groups.18 NOUN ct-10491 21 17 these these DET ct-10491 21 18 authors author NOUN ct-10491 21 19 concluded conclude VERB ct-10491 21 20 that that SCONJ ct-10491 21 21 carprofen carprofen PROPN ct-10491 21 22 was be AUX ct-10491 21 23 safe safe ADJ ct-10491 21 24 to to PART ct-10491 21 25 treat treat VERB ct-10491 21 26 lactating lactate VERB ct-10491 21 27 dogs dog NOUN ct-10491 21 28 ; ; PUNCT ct-10491 21 29 however however ADV ct-10491 21 30 , , PUNCT ct-10491 21 31 no no DET ct-10491 21 32 pharmacokinetics pharmacokinetic NOUN ct-10491 21 33 analysis analysis NOUN ct-10491 21 34 was be AUX ct-10491 21 35 performed perform VERB ct-10491 21 36 in in ADP ct-10491 21 37 that that DET ct-10491 21 38 study study NOUN ct-10491 21 39 to to PART ct-10491 21 40 provide provide VERB ct-10491 21 41 further further ADJ ct-10491 21 42 information information NOUN ct-10491 21 43 on on ADP ct-10491 21 44 the the DET ct-10491 21 45 disposition disposition NOUN ct-10491 21 46 of of ADP ct-10491 21 47 carprofen carprofen NOUN ct-10491 21 48 in in ADP ct-10491 21 49 lactating lactate VERB ct-10491 21 50 dogs dog NOUN ct-10491 21 51 . . PUNCT ct-10491 22 1 our our PRON ct-10491 22 2 hypothesis hypothesis NOUN ct-10491 22 3 is be AUX ct-10491 22 4 based base VERB ct-10491 22 5 on on ADP ct-10491 22 6 the the DET ct-10491 22 7 work work NOUN ct-10491 22 8 performed perform VERB ct-10491 22 9 with with ADP ct-10491 22 10 other other ADJ ct-10491 22 11 nsaids nsaid NOUN ct-10491 22 12 in in ADP ct-10491 22 13 people people NOUN ct-10491 22 14 and and CCONJ ct-10491 22 15 other other ADJ ct-10491 22 16 animals animal NOUN ct-10491 22 17 and and CCONJ ct-10491 22 18 results result NOUN ct-10491 22 19 from from ADP ct-10491 22 20 carprofen carprofen PROPN ct-10491 22 21 concentrations concentration NOUN ct-10491 22 22 in in ADP ct-10491 22 23 canine canine NOUN ct-10491 22 24 milk milk NOUN ct-10491 22 25 . . PUNCT ct-10491 23 1 minimal minimal ADJ ct-10491 23 2 data datum NOUN ct-10491 23 3 are be AUX ct-10491 23 4 available available ADJ ct-10491 23 5 regarding regard VERB ct-10491 23 6 milk milk NOUN ct-10491 23 7 concentrations concentration NOUN ct-10491 23 8 for for ADP ct-10491 23 9 carprofen carprofen NOUN ct-10491 23 10 in in ADP ct-10491 23 11 dogs,17,18 dogs,17,18 PROPN ct-10491 23 12 but but CCONJ ct-10491 23 13 no no DET ct-10491 23 14 pharmacokinetic pharmacokinetic ADJ ct-10491 23 15 studies study NOUN ct-10491 23 16 have have AUX ct-10491 23 17 been be AUX ct-10491 23 18 reported report VERB ct-10491 23 19 that that PRON ct-10491 23 20 provide provide VERB ct-10491 23 21 direct direct ADJ ct-10491 23 22 measurements measurement NOUN ct-10491 23 23 of of ADP ct-10491 23 24 neonatal neonatal ADJ ct-10491 23 25 plasma plasma NOUN ct-10491 23 26 concentrations concentration NOUN ct-10491 23 27 , , PUNCT ct-10491 23 28 or or CCONJ ct-10491 23 29 to to PART ct-10491 23 30 examine examine VERB ct-10491 23 31 if if SCONJ ct-10491 23 32 the the DET ct-10491 23 33 pharmacokinetics pharmacokinetic NOUN ct-10491 23 34 in in ADP ct-10491 23 35 lactating lactate VERB ct-10491 23 36 dogs dog NOUN ct-10491 23 37 are be AUX ct-10491 23 38 different different ADJ ct-10491 23 39 from from ADP ct-10491 23 40 other other ADJ ct-10491 23 41 dogs dog NOUN ct-10491 23 42 . . PUNCT ct-10491 24 1 the the DET ct-10491 24 2 purpose purpose NOUN ct-10491 24 3 of of ADP ct-10491 24 4 our our PRON ct-10491 24 5 descriptive descriptive ADJ ct-10491 24 6 study study NOUN ct-10491 24 7 was be AUX ct-10491 24 8 to to PART ct-10491 24 9 determine determine VERB ct-10491 24 10 the the DET ct-10491 24 11 pharmacokinetic pharmacokinetic ADJ ct-10491 24 12 disposition disposition NOUN ct-10491 24 13 of of ADP ct-10491 24 14 carprofen carprofen NOUN ct-10491 24 15 in in ADP ct-10491 24 16 plasma plasma NOUN ct-10491 24 17 of of ADP ct-10491 24 18 lactating lactate VERB ct-10491 24 19 dogs dog NOUN ct-10491 24 20 , , PUNCT ct-10491 24 21 measure measure NOUN ct-10491 24 22 concentrations concentration NOUN ct-10491 24 23 in in ADP ct-10491 24 24 canine canine NOUN ct-10491 24 25 milk milk NOUN ct-10491 24 26 of of ADP ct-10491 24 27 treated treat VERB ct-10491 24 28 dogs dog NOUN ct-10491 24 29 , , PUNCT ct-10491 24 30 and and CCONJ ct-10491 24 31 measure measure VERB ct-10491 24 32 concentrations concentration NOUN ct-10491 24 33 in in ADP ct-10491 24 34 plasma plasma NOUN ct-10491 24 35 of of ADP ct-10491 24 36 nursing nursing NOUN ct-10491 24 37 pups pup NOUN ct-10491 24 38 . . PUNCT ct-10491 25 1 we we PRON ct-10491 25 2 predicted predict VERB ct-10491 25 3 that that SCONJ ct-10491 25 4 a a DET ct-10491 25 5 single single ADJ ct-10491 25 6 intravenous intravenous ADJ ct-10491 25 7 dose dose NOUN ct-10491 25 8 of of ADP ct-10491 25 9 carprofen carprofen PROPN ct-10491 25 10 in in ADP ct-10491 25 11 dogs dog NOUN ct-10491 25 12 will will AUX ct-10491 25 13 fail fail VERB ct-10491 25 14 to to PART ct-10491 25 15 produce produce VERB ct-10491 25 16 milk milk NOUN ct-10491 25 17 concentrations concentration NOUN ct-10491 25 18 in in ADP ct-10491 25 19 lactating lactate VERB ct-10491 25 20 dogs dog NOUN ct-10491 25 21 that that PRON ct-10491 25 22 exceed exceed VERB ct-10491 25 23 the the DET ct-10491 25 24 limit limit NOUN ct-10491 25 25 of of ADP ct-10491 25 26 quantification quantification NOUN ct-10491 25 27 in in ADP ct-10491 25 28 milk.18 milk.18 ADV ct-10491 25 29 we we PRON ct-10491 25 30 also also ADV ct-10491 25 31 hypothesized hypothesize VERB ct-10491 25 32 that that SCONJ ct-10491 25 33 pups pup NOUN ct-10491 25 34 nursing nurse VERB ct-10491 25 35 from from ADP ct-10491 25 36 dogs dog NOUN ct-10491 25 37 after after ADP ct-10491 25 38 a a DET ct-10491 25 39 single single ADJ ct-10491 25 40 intravenous intravenous ADJ ct-10491 25 41 carprofen carprofen NOUN ct-10491 25 42 treatment treatment NOUN ct-10491 25 43 will will AUX ct-10491 25 44 not not PART ct-10491 25 45 have have VERB ct-10491 25 46 detectable detectable ADJ ct-10491 25 47 concentrations concentration NOUN ct-10491 25 48 of of ADP ct-10491 25 49 carprofen carprofen NOUN ct-10491 25 50 in in ADP ct-10491 25 51 their their PRON ct-10491 25 52 plasma plasma NOUN ct-10491 25 53 . . PUNCT ct-10491 26 1 materials material NOUN ct-10491 26 2 and and CCONJ ct-10491 26 3 methods method NOUN ct-10491 26 4 exclusion exclusion NOUN ct-10491 26 5 / / SYM ct-10491 26 6 inclusion inclusion NOUN ct-10491 26 7 criteria criterion NOUN ct-10491 26 8 seven seven NUM ct-10491 26 9 dogs dog NOUN ct-10491 26 10 were be AUX ct-10491 26 11 enrolled enrol VERB ct-10491 26 12 in in ADP ct-10491 26 13 the the DET ct-10491 26 14 study study NOUN ct-10491 26 15 and and CCONJ ct-10491 26 16 recruited recruit VERB ct-10491 26 17 from from ADP ct-10491 26 18 privately privately ADV ct-10491 26 19 owned own VERB ct-10491 26 20 kennels kennel NOUN ct-10491 26 21 with with ADP ct-10491 26 22 approval approval NOUN ct-10491 26 23 via via ADP ct-10491 26 24 consent consent NOUN ct-10491 26 25 form form NOUN ct-10491 26 26 and and CCONJ ct-10491 26 27 a a DET ct-10491 26 28 factual factual ADJ ct-10491 26 29 sheet sheet NOUN ct-10491 26 30 on on ADP ct-10491 26 31 carprofen carprofen NOUN ct-10491 26 32 provided provide VERB ct-10491 26 33 from from ADP ct-10491 26 34 the the DET ct-10491 26 35 manufacturer manufacturer NOUN ct-10491 26 36 . . PUNCT ct-10491 27 1 the the DET ct-10491 27 2 ages age NOUN ct-10491 27 3 of of ADP ct-10491 27 4 the the DET ct-10491 27 5 dogs dog NOUN ct-10491 27 6 were be AUX ct-10491 27 7 2.5 2.5 NUM ct-10491 27 8 - - SYM ct-10491 27 9 6.0 6.0 NUM ct-10491 27 10 ( ( PUNCT ct-10491 27 11 average average ADJ ct-10491 27 12 4.34 4.34 NUM ct-10491 27 13 ) ) PUNCT ct-10491 27 14 years year NOUN ct-10491 27 15 and and CCONJ ct-10491 27 16 weighing weigh VERB ct-10491 27 17 between between ADP ct-10491 27 18 8.91 8.91 NUM ct-10491 27 19 and and CCONJ ct-10491 27 20 27.27 27.27 NUM ct-10491 27 21 kg kg NOUN ct-10491 27 22 ( ( PUNCT ct-10491 27 23 average average ADJ ct-10491 27 24 21.03 21.03 NUM ct-10491 27 25 kg kg NOUN ct-10491 27 26 ) ) PUNCT ct-10491 27 27 . . PUNCT ct-10491 28 1 litters litter NOUN ct-10491 28 2 ranged range VERB ct-10491 28 3 from from ADP ct-10491 28 4 16 16 NUM ct-10491 28 5 - - SYM ct-10491 28 6 39 39 NUM ct-10491 28 7 days day NOUN ct-10491 28 8 of of ADP ct-10491 28 9 age age NOUN ct-10491 28 10 ( ( PUNCT ct-10491 28 11 average average ADJ ct-10491 28 12 28 28 NUM ct-10491 28 13 days day NOUN ct-10491 28 14 ) ) PUNCT ct-10491 28 15 ; ; PUNCT ct-10491 28 16 pups pup NOUN ct-10491 28 17 weighed weigh VERB ct-10491 28 18 more more ADJ ct-10491 28 19 than than ADP ct-10491 28 20 300 300 NUM ct-10491 28 21 grams gram NOUN ct-10491 28 22 and and CCONJ ct-10491 28 23 were be AUX ct-10491 28 24 being be AUX ct-10491 28 25 fed feed VERB ct-10491 28 26 exclusively exclusively ADV ct-10491 28 27 maternal maternal ADJ ct-10491 28 28 milk milk NOUN ct-10491 28 29 . . PUNCT ct-10491 29 1 dogs dog NOUN ct-10491 29 2 and and CCONJ ct-10491 29 3 litters litter NOUN ct-10491 29 4 consisted consist VERB ct-10491 29 5 of of ADP ct-10491 29 6 2 2 NUM ct-10491 29 7 breeds breed NOUN ct-10491 29 8 : : PUNCT ct-10491 29 9 american american PROPN ct-10491 29 10 foxhound foxhound PROPN ct-10491 29 11 ( ( PUNCT ct-10491 29 12 n n NOUN ct-10491 29 13 = = SYM ct-10491 29 14 6 6 NUM ct-10491 29 15 ) ) PUNCT ct-10491 29 16 and and CCONJ ct-10491 29 17 cavalier cavalier ADJ ct-10491 29 18 king king NOUN ct-10491 29 19 charles charles PROPN ct-10491 29 20 spaniel spaniel PROPN ct-10491 29 21 ( ( PUNCT ct-10491 29 22 n n NOUN ct-10491 29 23 = = SYM ct-10491 29 24 1 1 NUM ct-10491 29 25 ) ) PUNCT ct-10491 29 26 . . PUNCT ct-10491 30 1 enrollment enrollment NOUN ct-10491 30 2 criteria criterion NOUN ct-10491 30 3 were be AUX ct-10491 30 4 : : PUNCT ct-10491 30 5 a. a. NOUN ct-10491 30 6 healthy healthy PROPN ct-10491 30 7 based base VERB ct-10491 30 8 on on ADP ct-10491 30 9 physical physical ADJ ct-10491 30 10 examination examination NOUN ct-10491 30 11 ; ; PUNCT ct-10491 30 12 b. b. PROPN ct-10491 30 13 uneventful uneventful ADJ ct-10491 30 14 whelping whelping NOUN ct-10491 30 15 or or CCONJ ct-10491 30 16 delivery delivery NOUN ct-10491 30 17 ; ; PUNCT ct-10491 30 18 c. c. NOUN ct-10491 30 19 at at ADV ct-10491 30 20 least least ADV ct-10491 30 21 14 14 NUM ct-10491 30 22 days day NOUN ct-10491 30 23 postpartum postpartum NOUN ct-10491 30 24 ; ; PUNCT ct-10491 30 25 and and CCONJ ct-10491 30 26 d. d. PROPN ct-10491 30 27 had have VERB ct-10491 30 28 no no DET ct-10491 30 29 exposure exposure NOUN ct-10491 30 30 to to ADP ct-10491 30 31 nsaids nsaid NOUN ct-10491 30 32 in in ADP ct-10491 30 33 the the DET ct-10491 30 34 30 30 NUM ct-10491 30 35 days day NOUN ct-10491 30 36 prior prior ADV ct-10491 30 37 to to ADP ct-10491 30 38 enrollment enrollment NOUN ct-10491 30 39 . . PUNCT ct-10491 31 1 physical physical ADJ ct-10491 31 2 examinations examination NOUN ct-10491 31 3 of of ADP ct-10491 31 4 dogs dog NOUN ct-10491 31 5 and and CCONJ ct-10491 31 6 visual visual ADJ ct-10491 31 7 assessment assessment NOUN ct-10491 31 8 of of ADP ct-10491 31 9 pups pup NOUN ct-10491 31 10 were be AUX ct-10491 31 11 performed perform VERB ct-10491 31 12 at at ADP ct-10491 31 13 the the DET ct-10491 31 14 start start NOUN ct-10491 31 15 of of ADP ct-10491 31 16 the the DET ct-10491 31 17 study study NOUN ct-10491 31 18 prior prior ADV ct-10491 31 19 to to ADP ct-10491 31 20 enrollment enrollment NOUN ct-10491 31 21 to to PART ct-10491 31 22 determine determine VERB ct-10491 31 23 whether whether SCONJ ct-10491 31 24 they they PRON ct-10491 31 25 were be AUX ct-10491 31 26 healthy healthy ADJ ct-10491 31 27 enough enough ADV ct-10491 31 28 for for ADP ct-10491 31 29 the the DET ct-10491 31 30 study study NOUN ct-10491 31 31 . . PUNCT ct-10491 32 1 daily daily ADJ ct-10491 32 2 weight weight NOUN ct-10491 32 3 gains gain NOUN ct-10491 32 4 were be AUX ct-10491 32 5 not not PART ct-10491 32 6 tracked track VERB ct-10491 32 7 during during ADP ct-10491 32 8 the the DET ct-10491 32 9 study study NOUN ct-10491 32 10 , , PUNCT ct-10491 32 11 but but CCONJ ct-10491 32 12 pups pup NOUN ct-10491 32 13 were be AUX ct-10491 32 14 weighed weigh VERB ct-10491 32 15 and and CCONJ ct-10491 32 16 monitored monitor VERB ct-10491 32 17 by by ADP ct-10491 32 18 the the DET ct-10491 32 19 breeders breeder NOUN ct-10491 32 20 prior prior ADV ct-10491 32 21 to to ADP ct-10491 32 22 the the DET ct-10491 32 23 start start NOUN ct-10491 32 24 of of ADP ct-10491 32 25 the the DET ct-10491 32 26 study study NOUN ct-10491 32 27 to to PART ct-10491 32 28 ensure ensure VERB ct-10491 32 29 they they PRON ct-10491 32 30 were be AUX ct-10491 32 31 over over ADP ct-10491 32 32 300 300 NUM ct-10491 32 33 grams gram NOUN ct-10491 32 34 . . PUNCT ct-10491 33 1 dogs dog NOUN ct-10491 33 2 were be AUX ct-10491 33 3 housed house VERB ct-10491 33 4 in in ADP ct-10491 33 5 their their PRON ct-10491 33 6 normal normal ADJ ct-10491 33 7 kennels kennel NOUN ct-10491 33 8 with with ADP ct-10491 33 9 their their PRON ct-10491 33 10 owners owner NOUN ct-10491 33 11 / / SYM ct-10491 33 12 breeders breeder NOUN ct-10491 33 13 and and CCONJ ct-10491 33 14 samples sample NOUN ct-10491 33 15 were be AUX ct-10491 33 16 taken take VERB ct-10491 33 17 on on ADP ct-10491 33 18 - - PUNCT ct-10491 33 19 site site NOUN ct-10491 33 20 without without ADP ct-10491 33 21 transportation transportation NOUN ct-10491 33 22 of of ADP ct-10491 33 23 any any DET ct-10491 33 24 animal animal NOUN ct-10491 33 25 ; ; PUNCT ct-10491 33 26 dogs dog NOUN ct-10491 33 27 met meet VERB ct-10491 33 28 enrollment enrollment NOUN ct-10491 33 29 criteria criterion NOUN ct-10491 33 30 . . PUNCT ct-10491 34 1 three three NUM ct-10491 34 2 dogs dog NOUN ct-10491 34 3 were be AUX ct-10491 34 4 excluded exclude VERB ct-10491 34 5 shortly shortly ADV ct-10491 34 6 after after SCONJ ct-10491 34 7 samples sample NOUN ct-10491 34 8 were be AUX ct-10491 34 9 started start VERB ct-10491 34 10 due due ADJ ct-10491 34 11 to to ADP ct-10491 34 12 : : PUNCT ct-10491 34 13 a a DET ct-10491 34 14 case case NOUN ct-10491 34 15 of of ADP ct-10491 34 16 mastitis mastitis NOUN ct-10491 34 17 present present ADJ ct-10491 34 18 at at ADP ct-10491 34 19 milk milk NOUN ct-10491 34 20 collection collection NOUN ct-10491 34 21 , , PUNCT ct-10491 34 22 difficulty difficulty NOUN ct-10491 34 23 in in ADP ct-10491 34 24 venous venous ADJ ct-10491 34 25 access access NOUN ct-10491 34 26 for for ADP ct-10491 34 27 sampling sampling NOUN ct-10491 34 28 , , PUNCT ct-10491 34 29 and and CCONJ ct-10491 34 30 inability inability NOUN ct-10491 34 31 to to PART ct-10491 34 32 collect collect VERB ct-10491 34 33 milk milk NOUN ct-10491 34 34 from from ADP ct-10491 34 35 a a DET ct-10491 34 36 third third ADJ ct-10491 34 37 dog dog NOUN ct-10491 34 38 . . PUNCT ct-10491 35 1 four four NUM ct-10491 35 2 out out ADP ct-10491 35 3 of of ADP ct-10491 35 4 7 7 NUM ct-10491 35 5 litters litter NOUN ct-10491 35 6 successfully successfully ADV ct-10491 35 7 provided provide VERB ct-10491 35 8 complete complete ADJ ct-10491 35 9 sets set NOUN ct-10491 35 10 ( ( PUNCT ct-10491 35 11 maternal maternal ADJ ct-10491 35 12 plasma plasma NOUN ct-10491 35 13 , , PUNCT ct-10491 35 14 milk milk NOUN ct-10491 35 15 , , PUNCT ct-10491 35 16 and and CCONJ ct-10491 35 17 pup pup VERB ct-10491 35 18 plasma plasma NOUN ct-10491 35 19 ) ) PUNCT ct-10491 35 20 . . PUNCT ct-10491 36 1 all all DET ct-10491 36 2 4 4 NUM ct-10491 36 3 litters litter NOUN ct-10491 36 4 sampled sample VERB ct-10491 36 5 ranged range VERB ct-10491 36 6 from from ADP ct-10491 36 7 16 16 NUM ct-10491 36 8 - - SYM ct-10491 36 9 24 24 NUM ct-10491 36 10 days day NOUN ct-10491 36 11 old old ADJ ct-10491 36 12 , , PUNCT ct-10491 36 13 with with ADP ct-10491 36 14 the the DET ct-10491 36 15 majority majority NOUN ct-10491 36 16 of of ADP ct-10491 36 17 the the DET ct-10491 36 18 pup pup ADJ ct-10491 36 19 diet diet NOUN ct-10491 36 20 consisting consist VERB ct-10491 36 21 of of ADP ct-10491 36 22 milk milk NOUN ct-10491 36 23 , , PUNCT ct-10491 36 24 but but CCONJ ct-10491 36 25 food food NOUN ct-10491 36 26 was be AUX ct-10491 36 27 available available ADJ ct-10491 36 28 for for ADP ct-10491 36 29 dogs dog NOUN ct-10491 36 30 at at ADP ct-10491 36 31 all all DET ct-10491 36 32 times time NOUN ct-10491 36 33 . . PUNCT ct-10491 37 1 the the DET ct-10491 37 2 study study NOUN ct-10491 37 3 and and CCONJ ct-10491 37 4 experimental experimental ADJ ct-10491 37 5 design design NOUN ct-10491 37 6 were be AUX ct-10491 37 7 reviewed review VERB ct-10491 37 8 and and CCONJ ct-10491 37 9 approved approve VERB ct-10491 37 10 by by ADP ct-10491 37 11 the the DET ct-10491 37 12 institutional institutional ADJ ct-10491 37 13 animal animal NOUN ct-10491 37 14 care care NOUN ct-10491 37 15 and and CCONJ ct-10491 37 16 use use VERB ct-10491 37 17 committee committee NOUN ct-10491 37 18 at at ADP ct-10491 37 19 north north PROPN ct-10491 37 20 carolina carolina PROPN ct-10491 37 21 state state PROPN ct-10491 37 22 university university PROPN ct-10491 37 23 ( ( PUNCT ct-10491 37 24 protocol protocol NOUN ct-10491 37 25 21 21 NUM ct-10491 37 26 - - SYM ct-10491 37 27 382 382 NUM ct-10491 37 28 ) ) PUNCT ct-10491 37 29 . . PUNCT ct-10491 38 1 experimental experimental ADJ ct-10491 38 2 design design NOUN ct-10491 38 3 each each DET ct-10491 38 4 dog dog NOUN ct-10491 38 5 received receive VERB ct-10491 38 6 a a DET ct-10491 38 7 single single ADJ ct-10491 38 8 intravenous intravenous ADJ ct-10491 38 9 carprofen carprofen NOUN ct-10491 38 10 at at ADP ct-10491 38 11 the the DET ct-10491 38 12 fda fda PROPN ct-10491 38 13 approved approve VERB ct-10491 38 14 subcutaneous subcutaneous ADJ ct-10491 38 15 / / SYM ct-10491 38 16 oral oral ADJ ct-10491 38 17 dose dose NOUN ct-10491 38 18 of of ADP ct-10491 38 19 4.4 4.4 NUM ct-10491 38 20 mg mg PROPN ct-10491 38 21 / / SYM ct-10491 38 22 kg kg NOUN ct-10491 38 23 between between ADP ct-10491 38 24 14 14 NUM ct-10491 38 25 - - SYM ct-10491 38 26 39 39 NUM ct-10491 38 27 days day NOUN ct-10491 38 28 postpartum postpartum NOUN ct-10491 38 29 after after SCONJ ct-10491 38 30 blank blank ADJ ct-10491 38 31 plasma plasma NOUN ct-10491 38 32 and and CCONJ ct-10491 38 33 milk milk NOUN ct-10491 38 34 samples sample NOUN ct-10491 38 35 were be AUX ct-10491 38 36 collected collect VERB ct-10491 38 37 from from ADP ct-10491 38 38 each each DET ct-10491 38 39 dog dog NOUN ct-10491 38 40 ( ( PUNCT ct-10491 38 41 time time NOUN ct-10491 38 42 = = SYM ct-10491 38 43 0 0 NUM ct-10491 38 44 ) ) PUNCT ct-10491 38 45 . . PUNCT ct-10491 39 1 although although SCONJ ct-10491 39 2 the the DET ct-10491 39 3 intravenous intravenous ADJ ct-10491 39 4 route route NOUN ct-10491 39 5 of of ADP ct-10491 39 6 treatment treatment NOUN ct-10491 39 7 is be AUX ct-10491 39 8 not not PART ct-10491 39 9 included include VERB ct-10491 39 10 on on ADP ct-10491 39 11 the the DET ct-10491 39 12 approved approve VERB ct-10491 39 13 label label NOUN ct-10491 39 14 for for ADP ct-10491 39 15 dogs dog NOUN ct-10491 39 16 in in ADP ct-10491 39 17 the the DET ct-10491 39 18 us us PROPN ct-10491 39 19 , , PUNCT ct-10491 39 20 we we PRON ct-10491 39 21 chose choose VERB ct-10491 39 22 an an DET ct-10491 39 23 intravenous intravenous ADJ ct-10491 39 24 route route NOUN ct-10491 39 25 ( ( PUNCT ct-10491 39 26 extra extra ADJ ct-10491 39 27 - - ADJ ct-10491 39 28 label label ADJ ct-10491 39 29 use use NOUN ct-10491 39 30 ) ) PUNCT ct-10491 39 31 because because SCONJ ct-10491 39 32 : : PUNCT ct-10491 39 33 a. a. NOUN ct-10491 39 34 there there PRON ct-10491 39 35 were be VERB ct-10491 39 36 no no DET ct-10491 39 37 reported reported ADJ ct-10491 39 38 adverse adverse ADJ ct-10491 39 39 effects effect NOUN ct-10491 39 40 observed observe VERB ct-10491 39 41 in in ADP ct-10491 39 42 dogs dog NOUN ct-10491 39 43 from from ADP ct-10491 39 44 past past ADJ ct-10491 39 45 experimental experimental ADJ ct-10491 39 46 studies1,8,13 studies1,8,13 NOUN ct-10491 39 47 and and CCONJ ct-10491 39 48 in in ADP ct-10491 39 49 the the DET ct-10491 39 50 uk uk PROPN ct-10491 39 51 ; ; PUNCT ct-10491 39 52 b. b. PROPN ct-10491 39 53 intravenous intravenous PROPN ct-10491 39 54 dose dose PROPN ct-10491 39 55 ensures ensure VERB ct-10491 39 56 100 100 NUM ct-10491 39 57 % % NOUN ct-10491 39 58 bioavailability bioavailability NOUN ct-10491 39 59 that that PRON ct-10491 39 60 is be AUX ct-10491 39 61 important important ADJ ct-10491 39 62 for for ADP ct-10491 39 63 pharmacokinetic pharmacokinetic ADJ ct-10491 39 64 calculations calculation NOUN ct-10491 39 65 of of ADP ct-10491 39 66 clearance clearance NOUN ct-10491 39 67 and and CCONJ ct-10491 39 68 volume volume NOUN ct-10491 39 69 of of ADP ct-10491 39 70 distribution distribution NOUN ct-10491 39 71 ; ; PUNCT ct-10491 39 72 and and CCONJ ct-10491 39 73 c. c. NOUN ct-10491 39 74 our our PRON ct-10491 39 75 aim aim NOUN ct-10491 39 76 was be AUX ct-10491 39 77 to to PART ct-10491 39 78 calculate calculate VERB ct-10491 39 79 transfer transfer NOUN ct-10491 39 80 of of ADP ct-10491 39 81 drug drug NOUN ct-10491 39 82 from from ADP ct-10491 39 83 plasma plasma NOUN ct-10491 39 84 to to ADP ct-10491 39 85 milk milk NOUN ct-10491 39 86 , , PUNCT ct-10491 39 87 irrespective irrespective ADV ct-10491 39 88 of of ADP ct-10491 39 89 treatment treatment NOUN ct-10491 39 90 route route NOUN ct-10491 39 91 . . PUNCT ct-10491 40 1 a a DET ct-10491 40 2 single single ADJ ct-10491 40 3 milk milk NOUN ct-10491 40 4 and and CCONJ ct-10491 40 5 plasma plasma NOUN ct-10491 40 6 sample sample NOUN ct-10491 40 7 prior prior ADV ct-10491 40 8 to to ADP ct-10491 40 9 treatment treatment NOUN ct-10491 40 10 was be AUX ct-10491 40 11 collected collect VERB ct-10491 40 12 and and CCONJ ct-10491 40 13 measured measure VERB ct-10491 40 14 to to PART ct-10491 40 15 serve serve VERB ct-10491 40 16 as as ADP ct-10491 40 17 a a DET ct-10491 40 18 control control NOUN ct-10491 40 19 for for ADP ct-10491 40 20 each each DET ct-10491 40 21 female female NOUN ct-10491 40 22 , , PUNCT ct-10491 40 23 and and CCONJ ct-10491 40 24 then then ADV ct-10491 40 25 a a DET ct-10491 40 26 series series NOUN ct-10491 40 27 of of ADP ct-10491 40 28 milk milk NOUN ct-10491 40 29 and and CCONJ ct-10491 40 30 simultaneous simultaneous ADJ ct-10491 40 31 plasma plasma NOUN ct-10491 40 32 samples sample NOUN ct-10491 40 33 were be AUX ct-10491 40 34 collected collect VERB ct-10491 40 35 and and CCONJ ct-10491 40 36 measured measure VERB ct-10491 40 37 following follow VERB ct-10491 40 38 treatment treatment NOUN ct-10491 40 39 at at ADP ct-10491 40 40 predetermined predetermine VERB ct-10491 40 41 time time NOUN ct-10491 40 42 points point NOUN ct-10491 40 43 : : PUNCT ct-10491 40 44 0 0 NUM ct-10491 40 45 , , PUNCT ct-10491 40 46 0.5 0.5 NUM ct-10491 40 47 , , PUNCT ct-10491 40 48 1 1 NUM ct-10491 40 49 , , PUNCT ct-10491 40 50 1.5 1.5 NUM ct-10491 40 51 , , PUNCT ct-10491 40 52 2 2 NUM ct-10491 40 53 , , PUNCT ct-10491 40 54 8 8 NUM ct-10491 40 55 , , PUNCT ct-10491 40 56 12 12 NUM ct-10491 40 57 , , PUNCT ct-10491 40 58 24 24 NUM ct-10491 40 59 , , PUNCT ct-10491 40 60 36 36 NUM ct-10491 40 61 , , PUNCT ct-10491 40 62 48 48 NUM ct-10491 40 63 , , PUNCT ct-10491 40 64 and and CCONJ ct-10491 40 65 72 72 NUM ct-10491 40 66 hours.13 hours.13 NOUN ct-10491 40 67 repeated repeat VERB ct-10491 40 68 blood blood NOUN ct-10491 40 69 sampling sampling NOUN ct-10491 40 70 can can AUX ct-10491 40 71 be be AUX ct-10491 40 72 stressful stressful ADJ ct-10491 40 73 to to ADP ct-10491 40 74 young young ADJ ct-10491 40 75 pups pup NOUN ct-10491 40 76 ; ; PUNCT ct-10491 40 77 therefore therefore ADV ct-10491 40 78 , , PUNCT ct-10491 40 79 a a DET ct-10491 40 80 sparse sparse ADJ ct-10491 40 81 sampling sample VERB ct-10491 40 82 strategy strategy NOUN ct-10491 40 83 was be AUX ct-10491 40 84 used use VERB ct-10491 40 85 for for ADP ct-10491 40 86 pups pup NOUN ct-10491 40 87 in in ADP ct-10491 40 88 the the DET ct-10491 40 89 same same ADJ ct-10491 40 90 litters litter NOUN ct-10491 40 91 that that PRON ct-10491 40 92 were be AUX ct-10491 40 93 at at ADP ct-10491 40 94 least least ADJ ct-10491 40 95 14 14 NUM ct-10491 40 96 - - PUNCT ct-10491 40 97 days day NOUN ct-10491 40 98 - - PUNCT ct-10491 40 99 old old ADJ ct-10491 40 100 . . PUNCT ct-10491 41 1 this this PRON ct-10491 41 2 involved involve VERB ct-10491 41 3 taking take VERB ct-10491 41 4 a a DET ct-10491 41 5 maximum maximum ADJ ct-10491 41 6 volume volume NOUN ct-10491 41 7 of of ADP ct-10491 41 8 0.17 0.17 NUM ct-10491 41 9 ml ml NOUN ct-10491 41 10 . . PUNCT ct-10491 42 1 this this DET ct-10491 42 2 volume volume NOUN ct-10491 42 3 would would AUX ct-10491 42 4 not not PART ct-10491 42 5 exceed exceed VERB ct-10491 42 6 a a DET ct-10491 42 7 10 10 NUM ct-10491 42 8 % % NOUN ct-10491 42 9 blood blood NOUN ct-10491 42 10 loss loss NOUN ct-10491 42 11 over over ADP ct-10491 42 12 the the DET ct-10491 42 13 entire entire ADJ ct-10491 42 14 collection collection NOUN ct-10491 42 15 period period NOUN ct-10491 42 16 for for ADP ct-10491 42 17 a a DET ct-10491 42 18 pup pup NOUN ct-10491 42 19 weighing weigh VERB ct-10491 42 20 300 300 NUM ct-10491 42 21 grams gram NOUN ct-10491 42 22 . . PUNCT ct-10491 43 1 for for ADP ct-10491 43 2 each each DET ct-10491 43 3 time time NOUN ct-10491 43 4 point point NOUN ct-10491 43 5 , , PUNCT ct-10491 43 6 blood blood NOUN ct-10491 43 7 from from ADP ct-10491 43 8 at at ADP ct-10491 43 9 least least ADJ ct-10491 43 10 3 3 NUM ct-10491 43 11 pups pup NOUN ct-10491 43 12 within within ADP ct-10491 43 13 the the DET ct-10491 43 14 same same ADJ ct-10491 43 15 litter litter NOUN ct-10491 43 16 was be AUX ct-10491 43 17 pooled pool VERB ct-10491 43 18 that that PRON ct-10491 43 19 provided provide VERB ct-10491 43 20 sufficient sufficient ADJ ct-10491 43 21 sample sample NOUN ct-10491 43 22 for for ADP ct-10491 43 23 that that DET ct-10491 43 24 time time NOUN ct-10491 43 25 point point NOUN ct-10491 43 26 for for ADP ct-10491 43 27 analysis analysis NOUN ct-10491 43 28 . . PUNCT ct-10491 44 1 the the DET ct-10491 44 2 pharmacokinetic pharmacokinetic ADJ ct-10491 44 3 analysis analysis NOUN ct-10491 44 4 performed perform VERB ct-10491 44 5 used use VERB ct-10491 44 6 a a DET ct-10491 44 7 naïve naïve ADJ ct-10491 44 8 averaged average VERB ct-10491 44 9 data datum NOUN ct-10491 44 10 approach approach NOUN ct-10491 44 11 on on ADP ct-10491 44 12 a a DET ct-10491 44 13 rotational rotational ADJ ct-10491 44 14 basis basis NOUN ct-10491 44 15 to to PART ct-10491 44 16 minimize minimize VERB ct-10491 44 17 the the DET ct-10491 44 18 handling handling NOUN ct-10491 44 19 and and CCONJ ct-10491 44 20 venipuncture venipuncture NOUN ct-10491 44 21 of of ADP ct-10491 44 22 each each DET ct-10491 44 23 pup.25 pup.25 NOUN ct-10491 44 24 milk milk NOUN ct-10491 44 25 was be AUX ct-10491 44 26 collected collect VERB ct-10491 44 27 via via ADP ct-10491 44 28 manual manual ADJ ct-10491 44 29 expression expression NOUN ct-10491 44 30 into into ADP ct-10491 44 31 sterile sterile ADJ ct-10491 44 32 2 2 NUM ct-10491 44 33 - - PUNCT ct-10491 44 34 ml ml NOUN ct-10491 44 35 cryovials cryovial NOUN ct-10491 44 36 , , PUNCT ct-10491 44 37 with with ADP ct-10491 44 38 volumes volume NOUN ct-10491 44 39 measuring measure VERB ct-10491 44 40 20 20 NUM ct-10491 44 41 - - SYM ct-10491 44 42 1,000 1,000 NUM ct-10491 44 43 µl µl NOUN ct-10491 44 44 , , PUNCT ct-10491 44 45 and and CCONJ ct-10491 44 46 stored store VERB ct-10491 44 47 at at ADP ct-10491 44 48 – – PUNCT ct-10491 44 49 80 80 NUM ct-10491 44 50 ° ° NUM ct-10491 44 51 c c NOUN ct-10491 44 52 until until ADP ct-10491 44 53 analysis analysis NOUN ct-10491 44 54 . . PUNCT ct-10491 45 1 blood blood NOUN ct-10491 45 2 was be AUX ct-10491 45 3 collected collect VERB ct-10491 45 4 via via ADP ct-10491 45 5 venipuncture venipuncture NOUN ct-10491 45 6 into into ADP ct-10491 45 7 sterile sterile ADJ ct-10491 45 8 2 2 NUM ct-10491 45 9 - - PUNCT ct-10491 45 10 ml ml ADV ct-10491 45 11 heparinized heparinize VERB ct-10491 45 12 tubes tube NOUN ct-10491 45 13 at at ADP ct-10491 45 14 a a DET ct-10491 45 15 maximum maximum NOUN ct-10491 45 16 of of ADP ct-10491 45 17 4 4 NUM ct-10491 45 18 attempts attempt NOUN ct-10491 45 19 per per ADP ct-10491 45 20 dog dog NOUN ct-10491 45 21 or or CCONJ ct-10491 45 22 pup pup NOUN ct-10491 45 23 . . PUNCT ct-10491 46 1 the the DET ct-10491 46 2 samples sample NOUN ct-10491 46 3 were be AUX ct-10491 46 4 immediately immediately ADV ct-10491 46 5 placed place VERB ct-10491 46 6 on on ADP ct-10491 46 7 ice ice NOUN ct-10491 46 8 following follow VERB ct-10491 46 9 collection collection NOUN ct-10491 46 10 , , PUNCT ct-10491 46 11 centrifuged centrifuge VERB ct-10491 46 12 ( ( PUNCT ct-10491 46 13 20,000 20,000 NUM ct-10491 46 14 x x SYM ct-10491 46 15 g g PROPN ct-10491 46 16 10 10 NUM ct-10491 46 17 minutes minute NOUN ct-10491 46 18 ) ) PUNCT ct-10491 46 19 within within ADP ct-10491 46 20 30 30 NUM ct-10491 46 21 - - SYM ct-10491 46 22 90 90 NUM ct-10491 46 23 minutes minute NOUN ct-10491 46 24 after after ADP ct-10491 46 25 acquisition acquisition NOUN ct-10491 46 26 , , PUNCT ct-10491 46 27 the the DET ct-10491 46 28 plasma plasma NOUN ct-10491 46 29 was be AUX ct-10491 46 30 pipetted pipette VERB ct-10491 46 31 off off ADP ct-10491 46 32 and and CCONJ ct-10491 46 33 placed place VERB ct-10491 46 34 into into ADP ct-10491 46 35 sterile sterile ADJ ct-10491 46 36 2 2 NUM ct-10491 46 37 - - PUNCT ct-10491 46 38 ml ml NOUN ct-10491 46 39 cryovials cryovial NOUN ct-10491 46 40 , , PUNCT ct-10491 46 41 and and CCONJ ct-10491 46 42 plasma plasma NOUN ct-10491 46 43 stored store VERB ct-10491 46 44 at at ADP ct-10491 46 45 – – PUNCT ct-10491 46 46 80 80 NUM ct-10491 46 47 ° ° NUM ct-10491 46 48 c c NOUN ct-10491 46 49 until until ADP ct-10491 46 50 analysis analysis NOUN ct-10491 46 51 . . PUNCT ct-10491 47 1 high high ADJ ct-10491 47 2 performance performance NOUN ct-10491 47 3 liquid liquid NOUN ct-10491 47 4 chromatography chromatography NOUN ct-10491 47 5 high high ADJ ct-10491 47 6 performance performance NOUN ct-10491 47 7 liquid liquid NOUN ct-10491 47 8 chromatography chromatography NOUN ct-10491 47 9 ( ( PUNCT ct-10491 47 10 hplc hplc NOUN ct-10491 47 11 ; ; PUNCT ct-10491 47 12 or or CCONJ ct-10491 47 13 high high ADJ ct-10491 47 14 pressure pressure NOUN ct-10491 47 15 liquid liquid ADJ ct-10491 47 16 chromatography chromatography NOUN ct-10491 47 17 ) ) PUNCT ct-10491 47 18 was be AUX ct-10491 47 19 performed perform VERB ct-10491 47 20 on on ADP ct-10491 47 21 all all DET ct-10491 47 22 samples sample NOUN ct-10491 47 23 using use VERB ct-10491 47 24 validated validate VERB ct-10491 47 25 methods method NOUN ct-10491 47 26 developed develop VERB ct-10491 47 27 in in ADP ct-10491 47 28 our our PRON ct-10491 47 29 laboratory.13,26 laboratory.13,26 NOUN ct-10491 47 30 maternal maternal ADJ ct-10491 47 31 plasma plasma NOUN ct-10491 47 32 , , PUNCT ct-10491 47 33 milk milk NOUN ct-10491 47 34 , , PUNCT ct-10491 47 35 and and CCONJ ct-10491 47 36 pooled pool VERB ct-10491 47 37 neonatal neonatal ADJ ct-10491 47 38 plasma plasma NOUN ct-10491 47 39 samples sample NOUN ct-10491 47 40 were be AUX ct-10491 47 41 analyzed analyze VERB ct-10491 47 42 via via ADP ct-10491 47 43 hplc hplc NOUN ct-10491 47 44 to to PART ct-10491 47 45 determine determine VERB ct-10491 47 46 concentrations concentration NOUN ct-10491 47 47 of of ADP ct-10491 47 48 carprofen carprofen NOUN ct-10491 47 49 in in ADP ct-10491 47 50 plasma plasma NOUN ct-10491 47 51 and and CCONJ ct-10491 47 52 milk milk NOUN ct-10491 47 53 using use VERB ct-10491 47 54 methods method NOUN ct-10491 47 55 modified modify VERB ct-10491 47 56 from from ADP ct-10491 47 57 previous previous ADJ ct-10491 47 58 studies.10,13,26 studies.10,13,26 NOUN ct-10491 47 59 the the DET ct-10491 47 60 hplc hplc NOUN ct-10491 47 61 system system NOUN ct-10491 47 62 consisted consist VERB ct-10491 47 63 of of ADP ct-10491 47 64 a a DET ct-10491 47 65 4 4 NUM ct-10491 47 66 - - PUNCT ct-10491 47 67 solvent solvent ADJ ct-10491 47 68 delivery delivery NOUN ct-10491 47 69 system system NOUN ct-10491 47 70 , , PUNCT ct-10491 47 71 an an DET ct-10491 47 72 autosampler autosampler NOUN ct-10491 47 73 , , PUNCT ct-10491 47 74 and and CCONJ ct-10491 47 75 fluorescent fluorescent ADJ ct-10491 47 76 detection detection NOUN ct-10491 47 77 with with ADP ct-10491 47 78 an an DET ct-10491 47 79 emission emission NOUN ct-10491 47 80 wavelength wavelength NOUN ct-10491 47 81 set set VERB ct-10491 47 82 at at ADP ct-10491 47 83 310 310 NUM ct-10491 47 84 nm nm NOUN ct-10491 47 85 and and CCONJ ct-10491 47 86 detection detection NOUN ct-10491 47 87 wavelength wavelength NOUN ct-10491 47 88 set set VERB ct-10491 47 89 at at ADP ct-10491 47 90 375 375 NUM ct-10491 47 91 nm nm NOUN ct-10491 47 92 ( ( PUNCT ct-10491 47 93 agilent agilent PROPN ct-10491 47 94 1100 1100 NUM ct-10491 47 95 series series PROPN ct-10491 47 96 : : PUNCT ct-10491 47 97 agilent agilent PROPN ct-10491 47 98 technologies technologies PROPN ct-10491 47 99 , , PUNCT ct-10491 47 100 wilmington wilmington PROPN ct-10491 47 101 , , PUNCT ct-10491 47 102 de de PROPN ct-10491 47 103 , , PUNCT ct-10491 47 104 usa).13 usa).13 PRON ct-10491 47 105 the the DET ct-10491 47 106 chromatogram chromatogram PROPN ct-10491 47 107 was be AUX ct-10491 47 108 integrated integrate VERB ct-10491 47 109 with with ADP ct-10491 47 110 proprietary proprietary ADJ ct-10491 47 111 software software NOUN ct-10491 47 112 ( ( PUNCT ct-10491 47 113 openlab openlab VERB ct-10491 47 114 cds cds PROPN ct-10491 47 115 , , PUNCT ct-10491 47 116 agilent agilent PROPN ct-10491 47 117 technologies technologies PROPN ct-10491 47 118 , , PUNCT ct-10491 47 119 wilmington wilmington PROPN ct-10491 47 120 , , PUNCT ct-10491 47 121 de de PROPN ct-10491 47 122 , , PUNCT ct-10491 47 123 usa usa PROPN ct-10491 47 124 ) ) PUNCT ct-10491 47 125 . . PUNCT ct-10491 48 1 two two NUM ct-10491 48 2 columns column NOUN ct-10491 48 3 were be AUX ct-10491 48 4 used use VERB ct-10491 48 5 for for ADP ct-10491 48 6 analysis analysis NOUN ct-10491 48 7 , , PUNCT ct-10491 48 8 depending depend VERB ct-10491 48 9 on on ADP ct-10491 48 10 the the DET ct-10491 48 11 sample sample NOUN ct-10491 48 12 analyzed analyze VERB ct-10491 48 13 . . PUNCT ct-10491 49 1 all all DET ct-10491 49 2 maternal maternal ADJ ct-10491 49 3 plasma plasma NOUN ct-10491 49 4 was be AUX ct-10491 49 5 analyzed analyze VERB ct-10491 49 6 with with ADP ct-10491 49 7 a a DET ct-10491 49 8 chiral chiral ADJ ct-10491 49 9 column column NOUN ct-10491 49 10 ( ( PUNCT ct-10491 49 11 ultron ultron NOUN ct-10491 49 12 es es NOUN ct-10491 49 13 - - PUNCT ct-10491 49 14 ovm ovm NOUN ct-10491 49 15 ) ) PUNCT ct-10491 49 16 in in ADP ct-10491 49 17 a a DET ct-10491 49 18 column column NOUN ct-10491 49 19 oven oven NOUN ct-10491 49 20 of of ADP ct-10491 49 21 40 40 NUM ct-10491 49 22 ° ° NOUN ct-10491 49 23 c c NOUN ct-10491 49 24 that that PRON ct-10491 49 25 produced produce VERB ct-10491 49 26 separation separation NOUN ct-10491 49 27 of of ADP ct-10491 49 28 the the DET ct-10491 49 29 rand rand NOUN ct-10491 49 30 s s NOUN ct-10491 49 31 - - PUNCT ct-10491 49 32 enantiomers enantiomer NOUN ct-10491 49 33 with with ADP ct-10491 49 34 the the DET ct-10491 49 35 r r NOUN ct-10491 49 36 - - PUNCT ct-10491 49 37 enantiomer enantiomer NOUN ct-10491 49 38 eluting eluting NOUN ct-10491 49 39 from from ADP ct-10491 49 40 the the DET ct-10491 49 41 column column NOUN ct-10491 49 42 first first ADV ct-10491 49 43 . . PUNCT ct-10491 50 1 because because SCONJ ct-10491 50 2 of of ADP ct-10491 50 3 the the DET ct-10491 50 4 smaller small ADJ ct-10491 50 5 volume volume NOUN ct-10491 50 6 available available ADJ ct-10491 50 7 for for ADP ct-10491 50 8 analysis analysis NOUN ct-10491 50 9 , , PUNCT ct-10491 50 10 all all DET ct-10491 50 11 milk milk NOUN ct-10491 50 12 and and CCONJ ct-10491 50 13 neonatal neonatal ADJ ct-10491 50 14 samples sample NOUN ct-10491 50 15 were be AUX ct-10491 50 16 analyzed analyze VERB ct-10491 50 17 with with ADP ct-10491 50 18 a a DET ct-10491 50 19 nonchiral nonchiral ADJ ct-10491 50 20 column column NOUN ct-10491 50 21 ( ( PUNCT ct-10491 50 22 zorbax zorbax NOUN ct-10491 50 23 eclipse eclipse VERB ct-10491 50 24 xdb xdb ADJ ct-10491 50 25 - - PUNCT ct-10491 50 26 c18 c18 NOUN ct-10491 50 27 column column NOUN ct-10491 50 28 , , PUNCT ct-10491 50 29 agilent agilent PROPN ct-10491 50 30 technologies technologies PROPN ct-10491 50 31 ) ) PUNCT ct-10491 50 32 . . PUNCT ct-10491 51 1 the the DET ct-10491 51 2 mobile mobile ADJ ct-10491 51 3 phase phase NOUN ct-10491 51 4 for for ADP ct-10491 51 5 the the DET ct-10491 51 6 chiral chiral ADJ ct-10491 51 7 http://dx.doi.org/10.58292/ct.v16.10491 http://dx.doi.org/10.58292/ct.v16.10491 NOUN ct-10491 51 8 citation citation NOUN ct-10491 51 9 : : PUNCT ct-10491 51 10 clinical clinical ADJ ct-10491 51 11 theriogenology theriogenology NOUN ct-10491 51 12 2024 2024 NUM ct-10491 51 13 , , PUNCT ct-10491 51 14 16 16 NUM ct-10491 51 15 , , PUNCT ct-10491 51 16 10491 10491 NUM ct-10491 51 17 , , PUNCT ct-10491 51 18 http://dx.doi.org/10.58292/ct.v16.10491 http://dx.doi.org/10.58292/ct.v16.10491 NOUN ct-10491 51 19 3 3 NUM ct-10491 51 20 column column NOUN ct-10491 51 21 was be AUX ct-10491 51 22 isocratic isocratic ADJ ct-10491 51 23 at at ADP ct-10491 51 24 85 85 NUM ct-10491 51 25 % % NOUN ct-10491 51 26 0.02 0.02 NUM ct-10491 51 27 m m NOUN ct-10491 51 28 potassium potassium NOUN ct-10491 51 29 phosphate phosphate NOUN ct-10491 51 30 in in ADP ct-10491 51 31 water water NOUN ct-10491 51 32 and and CCONJ ct-10491 51 33 15 15 NUM ct-10491 51 34 % % NOUN ct-10491 51 35 acetonitrile acetonitrile NOUN ct-10491 51 36 at at ADP ct-10491 51 37 a a DET ct-10491 51 38 flow flow NOUN ct-10491 51 39 rate rate NOUN ct-10491 51 40 of of ADP ct-10491 51 41 1 1 NUM ct-10491 51 42 ml ml NOUN ct-10491 51 43 / / SYM ct-10491 51 44 minute minute NOUN ct-10491 51 45 . . PUNCT ct-10491 52 1 the the DET ct-10491 52 2 mobile mobile ADJ ct-10491 52 3 phase phase NOUN ct-10491 52 4 for for ADP ct-10491 52 5 the the DET ct-10491 52 6 nonchiral nonchiral ADJ ct-10491 52 7 column column NOUN ct-10491 52 8 was be AUX ct-10491 52 9 set set VERB ct-10491 52 10 to to ADP ct-10491 52 11 55 55 NUM ct-10491 52 12 % % NOUN ct-10491 52 13 0.02 0.02 NUM ct-10491 52 14 m m NOUN ct-10491 52 15 potassium potassium NOUN ct-10491 52 16 phosphate phosphate NOUN ct-10491 52 17 in in ADP ct-10491 52 18 water water NOUN ct-10491 52 19 and and CCONJ ct-10491 52 20 45 45 NUM ct-10491 52 21 % % NOUN ct-10491 52 22 acetonitrile acetonitrile NOUN ct-10491 52 23 at at ADP ct-10491 52 24 a a DET ct-10491 52 25 flow flow NOUN ct-10491 52 26 rate rate NOUN ct-10491 52 27 of of ADP ct-10491 52 28 1 1 NUM ct-10491 52 29 ml ml NOUN ct-10491 52 30 / / SYM ct-10491 52 31 minute minute NOUN ct-10491 52 32 . . PUNCT ct-10491 53 1 the the DET ct-10491 53 2 methods method NOUN ct-10491 53 3 used use VERB ct-10491 53 4 were be AUX ct-10491 53 5 validated validate VERB ct-10491 53 6 in in ADP ct-10491 53 7 our our PRON ct-10491 53 8 laboratory laboratory NOUN ct-10491 53 9 for for ADP ct-10491 53 10 canine canine NOUN ct-10491 53 11 plasma plasma NOUN ct-10491 53 12 . . PUNCT ct-10491 54 1 a a DET ct-10491 54 2 fresh fresh ADJ ct-10491 54 3 calibration calibration NOUN ct-10491 54 4 curve curve NOUN ct-10491 54 5 ( ( PUNCT ct-10491 54 6 described describe VERB ct-10491 54 7 below below ADV ct-10491 54 8 ) ) PUNCT ct-10491 54 9 and and CCONJ ct-10491 54 10 quality quality NOUN ct-10491 54 11 control control NOUN ct-10491 54 12 ( ( PUNCT ct-10491 54 13 qc qc PROPN ct-10491 54 14 ) ) PUNCT ct-10491 54 15 samples sample NOUN ct-10491 54 16 were be AUX ct-10491 54 17 analyzed analyze VERB ct-10491 54 18 with with ADP ct-10491 54 19 each each DET ct-10491 54 20 batch batch NOUN ct-10491 54 21 of of ADP ct-10491 54 22 samples sample NOUN ct-10491 54 23 to to PART ct-10491 54 24 ensure ensure VERB ct-10491 54 25 that that SCONJ ct-10491 54 26 the the DET ct-10491 54 27 assay assay NOUN ct-10491 54 28 met meet VERB ct-10491 54 29 our our PRON ct-10491 54 30 acceptance acceptance NOUN ct-10491 54 31 criteria criterion NOUN ct-10491 54 32 . . PUNCT ct-10491 55 1 calibration calibration NOUN ct-10491 55 2 standards standard VERB ct-10491 55 3 a a DET ct-10491 55 4 stock stock NOUN ct-10491 55 5 solution solution NOUN ct-10491 55 6 of of ADP ct-10491 55 7 carprofen carprofen PROPN ct-10491 55 8 was be AUX ct-10491 55 9 prepared prepare VERB ct-10491 55 10 using use VERB ct-10491 55 11 a a DET ct-10491 55 12 racemic racemic ADJ ct-10491 55 13 reference reference NOUN ct-10491 55 14 standard standard NOUN ct-10491 55 15 from from ADP ct-10491 55 16 the the DET ct-10491 55 17 us us PROPN ct-10491 55 18 pharmacopeial pharmacopeial ADJ ct-10491 55 19 convention convention NOUN ct-10491 55 20 and and CCONJ ct-10491 55 21 dissolved dissolve VERB ct-10491 55 22 in in ADP ct-10491 55 23 methanol methanol NOUN ct-10491 55 24 to to ADP ct-10491 55 25 1,000 1,000 NUM ct-10491 55 26 μg μg NOUN ct-10491 55 27 / / SYM ct-10491 55 28 ml ml ADP ct-10491 55 29 this this PRON ct-10491 55 30 was be AUX ct-10491 55 31 stored store VERB ct-10491 55 32 at at ADP ct-10491 55 33 refrigeration refrigeration NOUN ct-10491 55 34 temperature temperature NOUN ct-10491 55 35 in in ADP ct-10491 55 36 a a DET ct-10491 55 37 closed closed ADJ ct-10491 55 38 container container NOUN ct-10491 55 39 and and CCONJ ct-10491 55 40 used use VERB ct-10491 55 41 to to PART ct-10491 55 42 fortify fortify VERB ct-10491 55 43 blank blank ADP ct-10491 55 44 the the DET ct-10491 55 45 matrix matrix NOUN ct-10491 55 46 for for ADP ct-10491 55 47 standard standard ADJ ct-10491 55 48 calibration calibration NOUN ct-10491 55 49 samples sample NOUN ct-10491 55 50 for for ADP ct-10491 55 51 all all DET ct-10491 55 52 3 3 NUM ct-10491 55 53 sampling sample VERB ct-10491 55 54 groups.26 groups.26 NOUN ct-10491 55 55 - - PUNCT ct-10491 55 56 28 28 NUM ct-10491 55 57 the the DET ct-10491 55 58 calibration calibration NOUN ct-10491 55 59 curve curve NOUN ct-10491 55 60 for for ADP ct-10491 55 61 maternal maternal ADJ ct-10491 55 62 plasma plasma NOUN ct-10491 55 63 consisted consist VERB ct-10491 55 64 of of ADP ct-10491 55 65 6 6 NUM ct-10491 55 66 standards standard NOUN ct-10491 55 67 ranging range VERB ct-10491 55 68 from from ADP ct-10491 55 69 0.1 0.1 NUM ct-10491 55 70 - - SYM ct-10491 55 71 50 50 NUM ct-10491 55 72 μg μg NOUN ct-10491 55 73 / / SYM ct-10491 55 74 ml ml NOUN ct-10491 55 75 and and CCONJ ct-10491 55 76 5 5 NUM ct-10491 55 77 standards standard NOUN ct-10491 55 78 ranging range VERB ct-10491 55 79 from from ADP ct-10491 55 80 0.05 0.05 NUM ct-10491 55 81 - - SYM ct-10491 55 82 1 1 NUM ct-10491 55 83 μg μg NOUN ct-10491 55 84 / / SYM ct-10491 55 85 ml ml X ct-10491 55 86 for for ADP ct-10491 55 87 both both CCONJ ct-10491 55 88 milk milk NOUN ct-10491 55 89 and and CCONJ ct-10491 55 90 pup pup VERB ct-10491 55 91 plasma plasma NOUN ct-10491 55 92 of of ADP ct-10491 55 93 the the DET ct-10491 55 94 racemic racemic ADJ ct-10491 55 95 mixture mixture NOUN ct-10491 55 96 . . PUNCT ct-10491 56 1 since since SCONJ ct-10491 56 2 specific specific ADJ ct-10491 56 3 enantiomer enantiomer NOUN ct-10491 56 4 concentrations concentration NOUN ct-10491 56 5 were be AUX ct-10491 56 6 being be AUX ct-10491 56 7 measured measure VERB ct-10491 56 8 for for ADP ct-10491 56 9 maternal maternal ADJ ct-10491 56 10 plasma plasma NOUN ct-10491 56 11 , , PUNCT ct-10491 56 12 enantiomer enantiomer NOUN ct-10491 56 13 specific specific ADJ ct-10491 56 14 calibration calibration NOUN ct-10491 56 15 curves curve NOUN ct-10491 56 16 were be AUX ct-10491 56 17 based base VERB ct-10491 56 18 on on ADP ct-10491 56 19 rand rand NOUN ct-10491 56 20 s+ s+ PUNCT ct-10491 56 21 concentrations concentration NOUN ct-10491 56 22 of of ADP ct-10491 56 23 0.05 0.05 NUM ct-10491 56 24 - - SYM ct-10491 56 25 25 25 NUM ct-10491 56 26 µg µg NOUN ct-10491 56 27 / / SYM ct-10491 56 28 ml ml NOUN ct-10491 56 29 as as ADP ct-10491 56 30 rand rand NOUN ct-10491 56 31 s+ s+ ADV ct-10491 56 32 are be AUX ct-10491 56 33 in in ADP ct-10491 56 34 a a DET ct-10491 56 35 50:50 50:50 NUM ct-10491 56 36 ratio ratio NOUN ct-10491 56 37 in in ADP ct-10491 56 38 the the DET ct-10491 56 39 racemic racemic ADJ ct-10491 56 40 mixture mixture NOUN ct-10491 56 41 . . PUNCT ct-10491 57 1 calibration calibration NOUN ct-10491 57 2 curves curve NOUN ct-10491 57 3 were be AUX ct-10491 57 4 accepted accept VERB ct-10491 57 5 if if SCONJ ct-10491 57 6 the the DET ct-10491 57 7 linear linear ADJ ct-10491 57 8 coefficient coefficient NOUN ct-10491 57 9 of of ADP ct-10491 57 10 determination determination NOUN ct-10491 57 11 ( ( PUNCT ct-10491 57 12 r2 r2 PROPN ct-10491 57 13 ) ) PUNCT ct-10491 57 14 was be AUX ct-10491 57 15 ≥ ≥ NOUN ct-10491 57 16 0.99 0.99 NUM ct-10491 57 17 . . PUNCT ct-10491 58 1 the the DET ct-10491 58 2 limit limit NOUN ct-10491 58 3 of of ADP ct-10491 58 4 detection detection NOUN ct-10491 58 5 ( ( PUNCT ct-10491 58 6 lod lod PROPN ct-10491 58 7 ) ) PUNCT ct-10491 58 8 was be AUX ct-10491 58 9 0.01 0.01 NUM ct-10491 58 10 μg μg NOUN ct-10491 58 11 / / SYM ct-10491 58 12 ml ml PROPN ct-10491 58 13 and and CCONJ ct-10491 58 14 the the DET ct-10491 58 15 limit limit NOUN ct-10491 58 16 of of ADP ct-10491 58 17 quantification quantification NOUN ct-10491 58 18 ( ( PUNCT ct-10491 58 19 loq loq PROPN ct-10491 58 20 ) ) PUNCT ct-10491 58 21 was be AUX ct-10491 58 22 0.03 0.03 NUM ct-10491 58 23 μg μg NOUN ct-10491 58 24 / / SYM ct-10491 58 25 ml ml PROPN ct-10491 58 26 , , PUNCT ct-10491 58 27 based base VERB ct-10491 58 28 on on ADP ct-10491 58 29 the the DET ct-10491 58 30 lowest low ADJ ct-10491 58 31 point point NOUN ct-10491 58 32 on on ADP ct-10491 58 33 a a DET ct-10491 58 34 linear linear ADJ ct-10491 58 35 calibration calibration NOUN ct-10491 58 36 curve curve NOUN ct-10491 58 37 that that PRON ct-10491 58 38 met meet VERB ct-10491 58 39 our our PRON ct-10491 58 40 acceptance acceptance NOUN ct-10491 58 41 criteria criterion NOUN ct-10491 58 42 . . PUNCT ct-10491 59 1 sample sample NOUN ct-10491 59 2 preparation preparation NOUN ct-10491 59 3 preparation preparation NOUN ct-10491 59 4 for for ADP ct-10491 59 5 all all DET ct-10491 59 6 plasma plasma NOUN ct-10491 59 7 , , PUNCT ct-10491 59 8 milk milk NOUN ct-10491 59 9 , , PUNCT ct-10491 59 10 calibration calibration NOUN ct-10491 59 11 , , PUNCT ct-10491 59 12 and and CCONJ ct-10491 59 13 blank blank ADJ ct-10491 59 14 samples sample NOUN ct-10491 59 15 were be AUX ct-10491 59 16 identical identical ADJ ct-10491 59 17 aside aside ADV ct-10491 59 18 from from ADP ct-10491 59 19 volume volume NOUN ct-10491 59 20 of of ADP ct-10491 59 21 sample sample NOUN ct-10491 59 22 and and CCONJ ct-10491 59 23 4 4 NUM ct-10491 59 24 % % NOUN ct-10491 59 25 phosphoric phosphoric NOUN ct-10491 59 26 acid acid NOUN ct-10491 59 27 due due ADP ct-10491 59 28 to to ADP ct-10491 59 29 sample sample NOUN ct-10491 59 30 volume volume NOUN ct-10491 59 31 available available ADJ ct-10491 59 32 . . PUNCT ct-10491 60 1 samples sample NOUN ct-10491 60 2 were be AUX ct-10491 60 3 thawed thaw VERB ct-10491 60 4 at at ADP ct-10491 60 5 room room NOUN ct-10491 60 6 temperature temperature NOUN ct-10491 60 7 the the DET ct-10491 60 8 day day NOUN ct-10491 60 9 of of ADP ct-10491 60 10 preparation preparation NOUN ct-10491 60 11 , , PUNCT ct-10491 60 12 and and CCONJ ct-10491 60 13 500 500 NUM ct-10491 60 14 μl μl NOUN ct-10491 60 15 was be AUX ct-10491 60 16 diluted dilute VERB ct-10491 60 17 in in ADP ct-10491 60 18 a a DET ct-10491 60 19 1:1 1:1 NUM ct-10491 60 20 ratio ratio NOUN ct-10491 60 21 with with ADP ct-10491 60 22 an an DET ct-10491 60 23 equivalent equivalent ADJ ct-10491 60 24 volume volume NOUN ct-10491 60 25 of of ADP ct-10491 60 26 4 4 NUM ct-10491 60 27 % % NOUN ct-10491 60 28 phosphoric phosphoric NOUN ct-10491 60 29 acid acid NOUN ct-10491 60 30 in in ADP ct-10491 60 31 water water NOUN ct-10491 60 32 and and CCONJ ct-10491 60 33 then then ADV ct-10491 60 34 centrifuged centrifuge VERB ct-10491 60 35 for for ADP ct-10491 60 36 5 5 NUM ct-10491 60 37 minutes minute NOUN ct-10491 60 38 at at ADP ct-10491 60 39 20,124 20,124 NUM ct-10491 60 40 x x SYM ct-10491 60 41 g. g. AUX ct-10491 60 42 the the DET ct-10491 60 43 diluted dilute VERB ct-10491 60 44     SPACE ct-10491 60 45 sample sample NOUN ct-10491 60 46 was be AUX ct-10491 60 47 loaded load VERB ct-10491 60 48 into into ADP ct-10491 60 49 labelled label VERB ct-10491 60 50 preconditioned preconditioned ADJ ct-10491 60 51 solid solid ADJ ct-10491 60 52 - - PUNCT ct-10491 60 53 phase phase NOUN ct-10491 60 54 extraction extraction NOUN ct-10491 60 55 cartridges cartridge NOUN ct-10491 60 56 ( ( PUNCT ct-10491 60 57 oasis oasis PROPN ct-10491 60 58 prime prime PROPN ct-10491 60 59 hlb hlb PROPN ct-10491 60 60 1 1 NUM ct-10491 60 61 ml ml NOUN ct-10491 60 62 ; ; PUNCT ct-10491 60 63 waters water NOUN ct-10491 60 64 corporation corporation NOUN ct-10491 60 65 , , PUNCT ct-10491 60 66 milford milford PROPN ct-10491 60 67 , , PUNCT ct-10491 60 68 ma ma PROPN ct-10491 60 69 , , PUNCT ct-10491 60 70 usa usa PROPN ct-10491 60 71 ) ) PUNCT ct-10491 60 72 , , PUNCT ct-10491 60 73 and and CCONJ ct-10491 60 74 washed wash VERB ct-10491 60 75 with with ADP ct-10491 60 76 a a DET ct-10491 60 77 5 5 NUM ct-10491 60 78 % % NOUN ct-10491 60 79 methanol methanol NOUN ct-10491 60 80 solution solution NOUN ct-10491 60 81 . . PUNCT ct-10491 61 1 carprofen carprofen PROPN ct-10491 61 2 was be AUX ct-10491 61 3 eluted elute VERB ct-10491 61 4 into into ADP ct-10491 61 5 clean clean ADJ ct-10491 61 6 tubes tube NOUN ct-10491 61 7 with with ADP ct-10491 61 8 1 1 NUM ct-10491 61 9 ml ml NOUN ct-10491 61 10 of of ADP ct-10491 61 11 a a DET ct-10491 61 12 90 90 NUM ct-10491 61 13 % % NOUN ct-10491 61 14 acetonitrile acetonitrile NOUN ct-10491 61 15 and and CCONJ ct-10491 61 16 10 10 NUM ct-10491 61 17 % % NOUN ct-10491 61 18 methanol methanol NOUN ct-10491 61 19 solution solution NOUN ct-10491 61 20 . . PUNCT ct-10491 62 1 the the DET ct-10491 62 2 eluates eluate NOUN ct-10491 62 3 were be AUX ct-10491 62 4 evaporated evaporate VERB ct-10491 62 5 at at ADP ct-10491 62 6 40 40 NUM ct-10491 62 7 ° ° NOUN ct-10491 62 8 c c NOUN ct-10491 62 9 and and CCONJ ct-10491 62 10 20 20 NUM ct-10491 62 11 psi psi NOUN ct-10491 62 12 for for ADP ct-10491 62 13 25 25 NUM ct-10491 62 14 minutes minute NOUN ct-10491 62 15 . . PUNCT ct-10491 63 1 the the DET ct-10491 63 2 dry dry ADJ ct-10491 63 3 residue residue NOUN ct-10491 63 4 was be AUX ct-10491 63 5 reconstituted reconstitute VERB ct-10491 63 6 with with ADP ct-10491 63 7 250 250 NUM ct-10491 63 8     SPACE ct-10491 63 9 μl μl NOUN ct-10491 63 10 of of ADP ct-10491 63 11 the the DET ct-10491 63 12 mobile mobile ADJ ct-10491 63 13 phase phase NOUN ct-10491 63 14 . . PUNCT ct-10491 64 1 the the DET ct-10491 64 2 samples sample NOUN ct-10491 64 3 were be AUX ct-10491 64 4 vortexed vortexe VERB ct-10491 64 5 briefly briefly ADV ct-10491 64 6 and and CCONJ ct-10491 64 7 200 200 NUM ct-10491 64 8 μl μl CCONJ ct-10491 64 9 was be AUX ct-10491 64 10 transferred transfer VERB ct-10491 64 11 to to ADP ct-10491 64 12 hplc hplc NOUN ct-10491 64 13 injection injection NOUN ct-10491 64 14 vials vial NOUN ct-10491 64 15 , , PUNCT ct-10491 64 16 and and CCONJ ct-10491 64 17 20 20 NUM ct-10491 64 18 μl μl NOUN ct-10491 64 19 was be AUX ct-10491 64 20 injected inject VERB ct-10491 64 21 onto onto ADP ct-10491 64 22 the the DET ct-10491 64 23 column column NOUN ct-10491 64 24 . . PUNCT ct-10491 65 1 pharmacokinetics pharmacokinetic NOUN ct-10491 65 2 the the DET ct-10491 65 3 concentrations concentration NOUN ct-10491 65 4 measured measure VERB ct-10491 65 5 for for ADP ct-10491 65 6 maternal maternal ADJ ct-10491 65 7 and and CCONJ ct-10491 65 8 neonatal neonatal ADJ ct-10491 65 9 plasma plasma NOUN ct-10491 65 10 were be AUX ct-10491 65 11 averaged average VERB ct-10491 65 12 at at ADP ct-10491 65 13 each each DET ct-10491 65 14 timepoint timepoint NOUN ct-10491 65 15 and and CCONJ ct-10491 65 16 plotted plot VERB ct-10491 65 17 on on ADP ct-10491 65 18 nonlogarithmic nonlogarithmic ADJ ct-10491 65 19 and and CCONJ ct-10491 65 20 logarithmic logarithmic ADJ ct-10491 65 21 scale scale NOUN ct-10491 65 22 against against ADP ct-10491 65 23 time time NOUN ct-10491 65 24 to to PART ct-10491 65 25 initially initially ADV ct-10491 65 26 select select VERB ct-10491 65 27 the the DET ct-10491 65 28 best good ADJ ct-10491 65 29 model model NOUN ct-10491 65 30 for for ADP ct-10491 65 31 pharmacokinetic pharmacokinetic ADJ ct-10491 65 32 analysis analysis NOUN ct-10491 65 33 . . PUNCT ct-10491 66 1 pharmacokinetic pharmacokinetic ADJ ct-10491 66 2 analysis analysis NOUN ct-10491 66 3 was be AUX ct-10491 66 4 performed perform VERB ct-10491 66 5 with with ADP ct-10491 66 6 commercial commercial ADJ ct-10491 66 7 pharmacokinetic pharmacokinetic ADJ ct-10491 66 8 software software NOUN ct-10491 66 9 ( ( PUNCT ct-10491 66 10 phoenix phoenix PROPN ct-10491 66 11 ® ® NOUN ct-10491 66 12 winnonlin winnonlin AUX ct-10491 66 13 ™ ™ PROPN ct-10491 66 14 and and CCONJ ct-10491 66 15 nlme nlme PROPN ct-10491 66 16 ® ® NOUN ct-10491 66 17 , , PUNCT ct-10491 66 18 certara certara NOUN ct-10491 66 19 , , PUNCT ct-10491 66 20 st st PROPN ct-10491 66 21 . . PROPN ct-10491 66 22 louis louis PROPN ct-10491 66 23 mo mo PROPN ct-10491 66 24 ) ) PUNCT ct-10491 66 25 . . PUNCT ct-10491 67 1 pharmacokinetic pharmacokinetic ADJ ct-10491 67 2 models model NOUN ct-10491 67 3 were be AUX ct-10491 67 4 fitted fit VERB ct-10491 67 5 to to ADP ct-10491 67 6 the the DET ct-10491 67 7 data datum NOUN ct-10491 67 8 to to PART ct-10491 67 9 determine determine VERB ct-10491 67 10 the the DET ct-10491 67 11 best good ADJ ct-10491 67 12 fit.25,26,29 fit.25,26,29 NUM ct-10491 67 13 - - SYM ct-10491 67 14 31 31 NUM ct-10491 67 15 two two NUM ct-10491 67 16 compartment compartment NOUN ct-10491 67 17 modeling modeling NOUN ct-10491 67 18 is be AUX ct-10491 67 19 ideal ideal ADJ ct-10491 67 20 for for ADP ct-10491 67 21 intravenous intravenous ADJ ct-10491 67 22 treatment treatment NOUN ct-10491 67 23 as as ADP ct-10491 67 24 the the DET ct-10491 67 25 central central ADJ ct-10491 67 26 compartment compartment NOUN ct-10491 67 27 , , PUNCT ct-10491 67 28 or or CCONJ ct-10491 67 29 first first ADJ ct-10491 67 30 compartment compartment NOUN ct-10491 67 31 , , PUNCT ct-10491 67 32 is be AUX ct-10491 67 33 the the DET ct-10491 67 34 intravenous intravenous ADJ ct-10491 67 35 space space NOUN ct-10491 67 36 and and CCONJ ct-10491 67 37 the the DET ct-10491 67 38 second second ADJ ct-10491 67 39 compartment compartment NOUN ct-10491 67 40 is be AUX ct-10491 67 41 the the DET ct-10491 67 42 extravascular extravascular ADJ ct-10491 67 43 volume volume NOUN ct-10491 67 44 . . PUNCT ct-10491 68 1 this this DET ct-10491 68 2 type type NOUN ct-10491 68 3 of of ADP ct-10491 68 4 modeling modeling NOUN ct-10491 68 5 considers consider VERB ct-10491 68 6 the the DET ct-10491 68 7 movement movement NOUN ct-10491 68 8 between between ADP ct-10491 68 9 the the DET ct-10491 68 10 2 2 NUM ct-10491 68 11 compartments compartment NOUN ct-10491 68 12 . . PUNCT ct-10491 69 1 one one NUM ct-10491 69 2 dog dog NOUN ct-10491 69 3 was be AUX ct-10491 69 4 excluded exclude VERB ct-10491 69 5 from from ADP ct-10491 69 6 the the DET ct-10491 69 7 pharmacokinetic pharmacokinetic ADJ ct-10491 69 8 analysis analysis NOUN ct-10491 69 9 ( ( PUNCT ct-10491 69 10 dog dog NOUN ct-10491 69 11 4 4 NUM ct-10491 69 12 ) ) PUNCT ct-10491 69 13 because because SCONJ ct-10491 69 14 of of ADP ct-10491 69 15 inadequate inadequate ADJ ct-10491 69 16 samples sample NOUN ct-10491 69 17 collected collect VERB ct-10491 69 18 during during ADP ct-10491 69 19 the the DET ct-10491 69 20 first first ADJ ct-10491 69 21 24 24 NUM ct-10491 69 22 hours hour NOUN ct-10491 69 23 , , PUNCT ct-10491 69 24 resulting result VERB ct-10491 69 25 in in ADP ct-10491 69 26 only only ADV ct-10491 69 27 a a DET ct-10491 69 28 few few ADJ ct-10491 69 29 concentrations concentration NOUN ct-10491 69 30 in in ADP ct-10491 69 31 the the DET ct-10491 69 32 elimination elimination NOUN ct-10491 69 33 phase phase NOUN ct-10491 69 34 of of ADP ct-10491 69 35 the the DET ct-10491 69 36 curve curve NOUN ct-10491 69 37 . . PUNCT ct-10491 70 1 because because SCONJ ct-10491 70 2 there there PRON ct-10491 70 3 were be VERB ct-10491 70 4 only only ADV ct-10491 70 5 4 4 NUM ct-10491 70 6 litter litter NOUN ct-10491 70 7 samples sample NOUN ct-10491 70 8 and and CCONJ ct-10491 70 9 1 1 NUM ct-10491 70 10 milk milk NOUN ct-10491 70 11 sample sample NOUN ct-10491 70 12 being be AUX ct-10491 70 13 above above ADP ct-10491 70 14 the the DET ct-10491 70 15 loq loq PROPN ct-10491 70 16 , , PUNCT ct-10491 70 17 there there PRON ct-10491 70 18 were be VERB ct-10491 70 19 not not PART ct-10491 70 20 enough enough ADJ ct-10491 70 21 data datum NOUN ct-10491 70 22 to to PART ct-10491 70 23 perform perform VERB ct-10491 70 24 a a DET ct-10491 70 25 pharmacokinetic pharmacokinetic ADJ ct-10491 70 26 analysis analysis NOUN ct-10491 70 27 on on ADP ct-10491 70 28 dog dog NOUN ct-10491 70 29 milk milk NOUN ct-10491 70 30 or or CCONJ ct-10491 70 31 pup pup VERB ct-10491 70 32 plasma plasma NOUN ct-10491 70 33 . . PUNCT ct-10491 71 1 results result VERB ct-10491 71 2 all all DET ct-10491 71 3 maternal maternal ADJ ct-10491 71 4 plasma plasma NOUN ct-10491 71 5 carprofen carprofen NOUN ct-10491 71 6 concentrations concentration NOUN ct-10491 71 7 were be AUX ct-10491 71 8 below below ADP ct-10491 71 9 the the DET ct-10491 71 10 lod lod NOUN ct-10491 71 11 by by ADP ct-10491 71 12 24 24 NUM ct-10491 71 13 hours hour NOUN ct-10491 71 14 . . PUNCT ct-10491 72 1 postcarprofen postcarprofen NOUN ct-10491 72 2 treatment treatment NOUN ct-10491 72 3 ( ( PUNCT ct-10491 72 4 0 0 NUM ct-10491 72 5 - - SYM ct-10491 72 6 72 72 NUM ct-10491 72 7 h h NOUN ct-10491 72 8 ) ) PUNCT ct-10491 72 9 concentrations concentration NOUN ct-10491 72 10 ranged range VERB ct-10491 72 11 from from ADP ct-10491 72 12 0 0 NUM ct-10491 72 13 μg μg PROPN ct-10491 72 14 / / SYM ct-10491 72 15 ml ml NOUN ct-10491 72 16 to to ADP ct-10491 72 17 6.11 6.11 NUM ct-10491 72 18 µg µg NOUN ct-10491 72 19 / / SYM ct-10491 72 20 ml ml NOUN ct-10491 72 21 for for ADP ct-10491 72 22 the the DET ct-10491 72 23 r(- r(- PROPN ct-10491 72 24 ) ) PUNCT ct-10491 72 25 enantiomer enantiomer NOUN ct-10491 72 26 and and CCONJ ct-10491 72 27 0 0 NUM ct-10491 72 28 µg µg NOUN ct-10491 72 29 / / SYM ct-10491 72 30 ml ml NOUN ct-10491 72 31 to to ADP ct-10491 72 32 10.85 10.85 NUM ct-10491 72 33 μg μg NOUN ct-10491 72 34 / / SYM ct-10491 72 35 ml ml X ct-10491 72 36 for for ADP ct-10491 72 37 the the DET ct-10491 72 38 s(+ s(+ NOUN ct-10491 72 39 ) ) PUNCT ct-10491 72 40 enantiomer enantiomer NOUN ct-10491 72 41 ( ( PUNCT ct-10491 72 42 figure figure NOUN ct-10491 72 43 1 1 NUM ct-10491 72 44 ) ) PUNCT ct-10491 72 45 . . PUNCT ct-10491 73 1 figure figure NOUN ct-10491 73 2 1 1 NUM ct-10491 73 3 . . PUNCT ct-10491 74 1 pharmacokinetics pharmacokinetic NOUN ct-10491 74 2 of of ADP ct-10491 74 3 carprofen carprofen PROPN ct-10491 74 4 in in ADP ct-10491 74 5 dog dog NOUN ct-10491 74 6 ’s ’s PART ct-10491 74 7 plasma plasma NOUN ct-10491 74 8 after after ADP ct-10491 74 9 a a DET ct-10491 74 10 single single ADJ ct-10491 74 11 intravenous intravenous ADJ ct-10491 74 12 ( ( PUNCT ct-10491 74 13 4.4 4.4 NUM ct-10491 74 14 mg mg PROPN ct-10491 74 15 / / SYM ct-10491 74 16 kg kg PROPN ct-10491 74 17 ) ) PUNCT ct-10491 74 18 carprofen carprofen NOUN ct-10491 74 19 treatment treatment NOUN ct-10491 74 20 between between ADP ct-10491 74 21 days day NOUN ct-10491 74 22 16 16 NUM ct-10491 74 23 and and CCONJ ct-10491 74 24 24 24 NUM ct-10491 74 25 postpartum postpartum NOUN ct-10491 74 26 . . PUNCT ct-10491 75 1 a a DET ct-10491 75 2 2 2 NUM ct-10491 75 3 - - PUNCT ct-10491 75 4 compartment compartment NOUN ct-10491 75 5 pharmacokinetic pharmacokinetic ADJ ct-10491 75 6 modeling modeling NOUN ct-10491 75 7 system system NOUN ct-10491 75 8 on on ADP ct-10491 75 9 a a DET ct-10491 75 10 nonlogarithmic nonlogarithmic ADJ ct-10491 75 11 scale scale NOUN ct-10491 75 12 was be AUX ct-10491 75 13 used use VERB ct-10491 75 14 to to PART ct-10491 75 15 graph graph VERB ct-10491 75 16 the the DET ct-10491 75 17 r r NOUN ct-10491 75 18 - - PUNCT ct-10491 75 19 enantiomer enantiomer NOUN ct-10491 75 20 concentrations concentration NOUN ct-10491 75 21 of of ADP ct-10491 75 22 carprofen carprofen PROPN ct-10491 75 23 ( ( PUNCT ct-10491 75 24 black black ADJ ct-10491 75 25 circles circle NOUN ct-10491 75 26 ) ) PUNCT ct-10491 75 27 compared compare VERB ct-10491 75 28 to to ADP ct-10491 75 29 the the DET ct-10491 75 30 s s NOUN ct-10491 75 31 - - ADJ ct-10491 75 32 enantiomer enantiomer ADJ ct-10491 75 33 concentrations concentration NOUN ct-10491 75 34 of of ADP ct-10491 75 35 carprofen carprofen PROPN ct-10491 75 36 ( ( PUNCT ct-10491 75 37 purple purple ADJ ct-10491 75 38 squares square NOUN ct-10491 75 39 ) ) PUNCT ct-10491 75 40 against against ADP ct-10491 75 41 time time NOUN ct-10491 75 42 for for ADP ct-10491 75 43 plasma plasma NOUN ct-10491 75 44 samples sample NOUN ct-10491 75 45 from from ADP ct-10491 75 46 3 3 NUM ct-10491 75 47 dogs dog NOUN ct-10491 75 48 ( ( PUNCT ct-10491 75 49 between between ADP ct-10491 75 50 days day NOUN ct-10491 75 51 16 16 NUM ct-10491 75 52 and and CCONJ ct-10491 75 53 24 24 NUM ct-10491 75 54 postpartum postpartum NOUN ct-10491 75 55 ) ) PUNCT ct-10491 75 56 . . PUNCT ct-10491 76 1 http://dx.doi.org/10.58292/ct.v16.10491 http://dx.doi.org/10.58292/ct.v16.10491 NOUN ct-10491 76 2 4 4 NUM ct-10491 76 3 citation citation NOUN ct-10491 76 4 : : PUNCT ct-10491 76 5 clinical clinical ADJ ct-10491 76 6 theriogenology theriogenology NOUN ct-10491 76 7 2024 2024 NUM ct-10491 76 8 , , PUNCT ct-10491 76 9 16 16 NUM ct-10491 76 10 , , PUNCT ct-10491 76 11 10491 10491 NUM ct-10491 76 12 , , PUNCT ct-10491 76 13 http://dx.doi.org/10.58292/ct.v16.10491 http://dx.doi.org/10.58292/ct.v16.10491 NOUN ct-10491 76 14 maternal maternal ADJ ct-10491 76 15 carprofen carprofen NOUN ct-10491 76 16 concentrations concentration NOUN ct-10491 76 17 in in ADP ct-10491 76 18 plasma plasma NOUN ct-10491 76 19 averaged average VERB ct-10491 76 20 for for ADP ct-10491 76 21 each each DET ct-10491 76 22 timepoint timepoint VERB ct-10491 76 23 out out ADP ct-10491 76 24 to to PART ct-10491 76 25 24 24 NUM ct-10491 76 26 - - PUNCT ct-10491 76 27 hours hour NOUN ct-10491 76 28 on on ADP ct-10491 76 29 a a DET ct-10491 76 30 logarithmic logarithmic ADJ ct-10491 76 31 scale scale NOUN ct-10491 76 32 broken break VERB ct-10491 76 33 into into ADP ct-10491 76 34 rand rand NOUN ct-10491 76 35 s s NOUN ct-10491 76 36 - - PUNCT ct-10491 76 37 enantiomers enantiomer NOUN ct-10491 76 38 concentrations concentration NOUN ct-10491 76 39 , , PUNCT ct-10491 76 40 total total ADJ ct-10491 76 41 carprofen carprofen NOUN ct-10491 76 42 concentrations concentration NOUN ct-10491 76 43 in in ADP ct-10491 76 44 neonatal neonatal ADJ ct-10491 76 45 plasma plasma NOUN ct-10491 76 46 , , PUNCT ct-10491 76 47 and and CCONJ ct-10491 76 48 the the DET ct-10491 76 49 single single ADJ ct-10491 76 50 milk milk NOUN ct-10491 76 51 sample sample NOUN ct-10491 76 52 above above ADP ct-10491 76 53 loq loq PROPN ct-10491 76 54 . . PUNCT ct-10491 77 1 litters litter NOUN ct-10491 77 2 ’ ' PUNCT ct-10491 77 3 concentrations concentration NOUN ct-10491 77 4 were be AUX ct-10491 77 5 also also ADV ct-10491 77 6 averaged average VERB ct-10491 77 7 together together ADV ct-10491 77 8 for for ADP ct-10491 77 9 each each DET ct-10491 77 10 timepoint timepoint NOUN ct-10491 77 11 . . PUNCT ct-10491 78 1 s s X ct-10491 78 2 - - PUNCT ct-10491 78 3 enantiomer enantiomer ADJ ct-10491 78 4 concentrations concentration NOUN ct-10491 78 5 in in ADP ct-10491 78 6 red red ADJ ct-10491 78 7 circles circle NOUN ct-10491 78 8 , , PUNCT ct-10491 78 9 r r NOUN ct-10491 78 10 - - ADJ ct-10491 78 11 enantiomer enantiomer NOUN ct-10491 78 12 concentrations concentration NOUN ct-10491 78 13 in in ADP ct-10491 78 14 blue blue ADJ ct-10491 78 15 squares square NOUN ct-10491 78 16 , , PUNCT ct-10491 78 17 pup pup VERB ct-10491 78 18 plasma plasma NOUN ct-10491 78 19 concentrations concentration NOUN ct-10491 78 20 in in ADP ct-10491 78 21 green green ADJ ct-10491 78 22 diamonds diamond NOUN ct-10491 78 23 , , PUNCT ct-10491 78 24 and and CCONJ ct-10491 78 25 milk milk NOUN ct-10491 78 26 as as ADP ct-10491 78 27 a a DET ct-10491 78 28 black black ADJ ct-10491 78 29 triangle triangle NOUN ct-10491 78 30 . . PUNCT ct-10491 79 1 most most ADJ ct-10491 79 2 pup pup ADJ ct-10491 79 3 samples sample NOUN ct-10491 79 4 were be AUX ct-10491 79 5 below below ADP ct-10491 79 6 the the DET ct-10491 79 7 lod lod PROPN ct-10491 79 8 for for ADP ct-10491 79 9 most most ADJ ct-10491 79 10 time time NOUN ct-10491 79 11 points point NOUN ct-10491 79 12 with with ADP ct-10491 79 13 only only ADV ct-10491 79 14 17 17 NUM ct-10491 79 15 out out ADP ct-10491 79 16 of of ADP ct-10491 79 17 35 35 NUM ct-10491 79 18 samples sample NOUN ct-10491 79 19 being be AUX ct-10491 79 20 above above ADP ct-10491 79 21 the the DET ct-10491 79 22 lod lod PROPN ct-10491 79 23 . . PROPN ct-10491 79 24 out out ADP ct-10491 79 25 of of ADP ct-10491 79 26     SPACE ct-10491 79 27 these these DET ct-10491 79 28 17 17 NUM ct-10491 79 29 samples sample NOUN ct-10491 79 30 ; ; PUNCT ct-10491 79 31 however however ADV ct-10491 79 32 , , PUNCT ct-10491 79 33 only only ADV ct-10491 79 34 4 4 NUM ct-10491 79 35 were be AUX ct-10491 79 36 above above ADP ct-10491 79 37 the the DET ct-10491 79 38 loq loq PROPN ct-10491 79 39 . . PUNCT ct-10491 80 1 the the DET ct-10491 80 2     SPACE ct-10491 80 3 majority majority NOUN ct-10491 80 4 were be AUX ct-10491 80 5 in in ADP ct-10491 80 6 litter litter NOUN ct-10491 80 7 1 1 NUM ct-10491 80 8 ( ( PUNCT ct-10491 80 9 0.5 0.5 NUM ct-10491 80 10 , , PUNCT ct-10491 80 11 1.5 1.5 NUM ct-10491 80 12 , , PUNCT ct-10491 80 13 and and CCONJ ct-10491 80 14 12 12 NUM ct-10491 80 15 hours hour NOUN ct-10491 80 16 postmaternal postmaternal ADJ ct-10491 80 17 treatment treatment NOUN ct-10491 80 18 ) ) PUNCT ct-10491 80 19 and and CCONJ ct-10491 80 20 the the DET ct-10491 80 21 last last ADJ ct-10491 80 22 was be AUX ct-10491 80 23 at at ADP ct-10491 80 24 the the DET ct-10491 80 25 first first ADJ ct-10491 80 26 time time NOUN ct-10491 80 27 point point NOUN ct-10491 80 28 for for ADP ct-10491 80 29 litter litter NOUN ct-10491 80 30 2 2 NUM ct-10491 80 31 ( ( PUNCT ct-10491 80 32 0.5 0.5 NUM ct-10491 80 33 hour hour NOUN ct-10491 80 34 postmaternal postmaternal ADJ ct-10491 80 35 treatment treatment NOUN ct-10491 80 36 ) ) PUNCT ct-10491 80 37 . . PUNCT ct-10491 81 1 milk milk NOUN ct-10491 81 2 carprofen carprofen PROPN ct-10491 81 3 concentrations concentration NOUN ct-10491 81 4 were be AUX ct-10491 81 5 above above ADP ct-10491 81 6 the the DET ct-10491 81 7 loq loq PROPN ct-10491 81 8 and and CCONJ ct-10491 81 9 lod lod PROPN ct-10491 81 10 only only ADV ct-10491 81 11 at at ADP ct-10491 81 12 a a DET ct-10491 81 13 single single ADJ ct-10491 81 14 timepoint timepoint NOUN ct-10491 81 15 ( ( PUNCT ct-10491 81 16 12 12 NUM ct-10491 81 17 hours hour NOUN ct-10491 81 18 ) ) PUNCT ct-10491 81 19 in in ADP ct-10491 81 20 dog dog NOUN ct-10491 81 21 1 1 NUM ct-10491 81 22 . . PUNCT ct-10491 82 1 none none NOUN ct-10491 82 2 of of ADP ct-10491 82 3 the the DET ct-10491 82 4 neonatal neonatal ADJ ct-10491 82 5 plasma plasma NOUN ct-10491 82 6 concentrations concentration NOUN ct-10491 82 7 at at ADP ct-10491 82 8 any any DET ct-10491 82 9 time time NOUN ct-10491 82 10 point point NOUN ct-10491 82 11 were be AUX ct-10491 82 12 more more ADJ ct-10491 82 13 than than ADP ct-10491 82 14 10 10 NUM ct-10491 82 15 % % NOUN ct-10491 82 16 of of ADP ct-10491 82 17 the the DET ct-10491 82 18 total total ADJ ct-10491 82 19 maternal maternal ADJ ct-10491 82 20 plasma plasma NOUN ct-10491 82 21 concentrations concentration NOUN ct-10491 82 22 ( ( PUNCT ct-10491 82 23 figure figure NOUN ct-10491 82 24 2 2 NUM ct-10491 82 25 ) ) PUNCT ct-10491 82 26 . . PUNCT ct-10491 83 1 twenty twenty NUM ct-10491 83 2 - - PUNCT ct-10491 83 3 one one NUM ct-10491 83 4 concentration concentration NOUN ct-10491 83 5 - - PUNCT ct-10491 83 6 time time NOUN ct-10491 83 7 samples sample NOUN ct-10491 83 8 ( ( PUNCT ct-10491 83 9 time time NOUN ct-10491 83 10 0.5 0.5 NUM ct-10491 83 11 - - SYM ct-10491 83 12 24 24 NUM ct-10491 83 13 hours hour NOUN ct-10491 83 14 ) ) PUNCT ct-10491 83 15 from from ADP ct-10491 83 16 3 3 NUM ct-10491 83 17 dogs dog NOUN ct-10491 83 18 ( ( PUNCT ct-10491 83 19 16 16 NUM ct-10491 83 20 , , PUNCT ct-10491 83 21 22 22 NUM ct-10491 83 22 , , PUNCT ct-10491 83 23 and and CCONJ ct-10491 83 24 24 24 NUM ct-10491 83 25 days day NOUN ct-10491 83 26 postpartum postpartum NOUN ct-10491 83 27 for for ADP ct-10491 83 28 dogs dog NOUN ct-10491 83 29 1 1 NUM ct-10491 83 30 , , PUNCT ct-10491 83 31 2 2 NUM ct-10491 83 32 , , PUNCT ct-10491 83 33 and and CCONJ ct-10491 83 34 3 3 NUM ct-10491 83 35 respectively respectively ADV ct-10491 83 36 ) ) PUNCT ct-10491 83 37 were be AUX ct-10491 83 38 included include VERB ct-10491 83 39 into into ADP ct-10491 83 40 pharmacokinetic pharmacokinetic ADJ ct-10491 83 41 modeling modeling NOUN ct-10491 83 42 for for ADP ct-10491 83 43 both both DET ct-10491 83 44 rand rand NOUN ct-10491 83 45 s s NOUN ct-10491 83 46 - - NOUN ct-10491 83 47 enantiomer enantiomer NOUN ct-10491 83 48 of of ADP ct-10491 83 49 carprofen carprofen PROPN ct-10491 83 50 . . PUNCT ct-10491 84 1 our our PRON ct-10491 84 2 study study NOUN ct-10491 84 3 identified identify VERB ct-10491 84 4 multiple multiple ADJ ct-10491 84 5 differences difference NOUN ct-10491 84 6 in in ADP ct-10491 84 7 the the DET ct-10491 84 8 pharmacokinetic pharmacokinetic ADJ ct-10491 84 9 parameter parameter NOUN ct-10491 84 10 estimates estimate NOUN ct-10491 84 11 compared compare VERB ct-10491 84 12 to to ADP ct-10491 84 13 studies study NOUN ct-10491 84 14 . . PUNCT ct-10491 85 1 we we PRON ct-10491 85 2 observed observe VERB ct-10491 85 3 a a DET ct-10491 85 4 higher high ADJ ct-10491 85 5 clearance clearance NOUN ct-10491 85 6 rate rate NOUN ct-10491 85 7 compared compare VERB ct-10491 85 8 to to ADP ct-10491 85 9 studies study NOUN ct-10491 85 10 in in ADP ct-10491 85 11 healthy healthy ADJ ct-10491 85 12 and and CCONJ ct-10491 85 13 pain pain NOUN ct-10491 85 14 - - PUNCT ct-10491 85 15 induced induce VERB ct-10491 85 16 dogs.8,11,13,31,32 dogs.8,11,13,31,32 PROPN ct-10491 85 17 we we PRON ct-10491 85 18 also also ADV ct-10491 85 19 observed observe VERB ct-10491 85 20 a a DET ct-10491 85 21 higher high ADJ ct-10491 85 22 volume volume NOUN ct-10491 85 23 of of ADP ct-10491 85 24 distribution distribution NOUN ct-10491 85 25 in in ADP ct-10491 85 26 our our PRON ct-10491 85 27 dogs dog NOUN ct-10491 85 28 compared compare VERB ct-10491 85 29 to to ADP ct-10491 85 30 studies study NOUN ct-10491 85 31 – – PUNCT ct-10491 85 32 the the DET ct-10491 85 33 volume volume NOUN ct-10491 85 34 of of ADP ct-10491 85 35 distribution distribution NOUN ct-10491 85 36 for for ADP ct-10491 85 37 the the DET ct-10491 85 38 central central ADJ ct-10491 85 39 compartment compartment NOUN ct-10491 85 40 was be AUX ct-10491 85 41 2 2 NUM ct-10491 85 42 - - SYM ct-10491 85 43 3 3 NUM ct-10491 85 44 times time NOUN ct-10491 85 45 higher high ADJ ct-10491 85 46 than than SCONJ ct-10491 85 47 reported report VERB ct-10491 85 48 . . PUNCT ct-10491 86 1 enantiomer enantiomer NOUN ct-10491 86 2 - - PUNCT ct-10491 86 3 specific specific ADJ ct-10491 86 4 primary primary ADJ ct-10491 86 5 parameter parameter NOUN ct-10491 86 6 estimates estimate NOUN ct-10491 86 7 for for ADP ct-10491 86 8 total total ADJ ct-10491 86 9 ( ( PUNCT ct-10491 86 10 protein protein NOUN ct-10491 86 11 bound bind VERB ct-10491 86 12 and and CCONJ ct-10491 86 13 unbound unbound PROPN ct-10491 86 14 carprofen carprofen PROPN ct-10491 86 15 ) ) PUNCT ct-10491 86 16 are be AUX ct-10491 86 17 provided provide VERB ct-10491 86 18 ( ( PUNCT ct-10491 86 19 table table NOUN ct-10491 86 20 ) ) PUNCT ct-10491 86 21 . . PUNCT ct-10491 87 1 discussion discussion NOUN ct-10491 87 2 because because SCONJ ct-10491 87 3 of of ADP ct-10491 87 4 uncertainty uncertainty NOUN ct-10491 87 5 regarding regard VERB ct-10491 87 6 the the DET ct-10491 87 7 safety safety NOUN ct-10491 87 8 of of ADP ct-10491 87 9 carprofen carprofen NOUN ct-10491 87 10 to to ADP ct-10491 87 11 nursing nursing NOUN ct-10491 87 12 pups pup NOUN ct-10491 87 13 after after ADP ct-10491 87 14 carprofen carprofen NOUN ct-10491 87 15 treatment treatment NOUN ct-10491 87 16 to to ADP ct-10491 87 17 lactating lactate VERB ct-10491 87 18 dogs dog NOUN ct-10491 88 1 , , PUNCT ct-10491 88 2 we we PRON ct-10491 88 3 studied study VERB ct-10491 88 4 the the DET ct-10491 88 5 disposition disposition NOUN ct-10491 88 6 of of ADP ct-10491 88 7 carprofen carprofen NOUN ct-10491 88 8 in in ADP ct-10491 88 9 dogs dog NOUN ct-10491 88 10 ’ ' PUNCT ct-10491 88 11 plasma plasma NOUN ct-10491 88 12 and and CCONJ ct-10491 88 13 milk milk NOUN ct-10491 88 14 , , PUNCT ct-10491 88 15 and and CCONJ ct-10491 88 16 in in ADP ct-10491 88 17 nursing nursing NOUN ct-10491 88 18 pups pup NOUN ct-10491 88 19 ’ ' PUNCT ct-10491 88 20 plasma plasma NOUN ct-10491 88 21 . . PUNCT ct-10491 89 1 this this DET ct-10491 89 2 information information NOUN ct-10491 89 3 was be AUX ct-10491 89 4 needed need VERB ct-10491 89 5 because because SCONJ ct-10491 89 6 carprofen carprofen PROPN ct-10491 89 7 is be AUX ct-10491 89 8 one one NUM ct-10491 89 9 of of ADP ct-10491 89 10 the the DET ct-10491 89 11 most most ADV ct-10491 89 12 prescribed prescribed ADJ ct-10491 89 13 analgesics analgesic NOUN ct-10491 89 14 for for ADP ct-10491 89 15 perioperative perioperative ADJ ct-10491 89 16 use use NOUN ct-10491 89 17 , , PUNCT ct-10491 89 18 mastitis mastitis NOUN ct-10491 89 19 , , PUNCT ct-10491 89 20 metritis metritis NOUN ct-10491 89 21 , , PUNCT ct-10491 89 22 and and CCONJ ct-10491 89 23 osteoarthritis osteoarthritis NOUN ct-10491 89 24 in in ADP ct-10491 89 25 dogs dog NOUN ct-10491 89 26 that that PRON ct-10491 89 27 may may AUX ct-10491 89 28 be be AUX ct-10491 89 29 lactating lactate VERB ct-10491 89 30 . . PUNCT ct-10491 90 1 although although SCONJ ct-10491 90 2 we we PRON ct-10491 90 3 were be AUX ct-10491 90 4 unable unable ADJ ct-10491 90 5 to to PART ct-10491 90 6 analyze analyze VERB ct-10491 90 7 0 0 NUM ct-10491 90 8 2 2 NUM ct-10491 90 9 4 4 NUM ct-10491 90 10 6 6 NUM ct-10491 90 11 8 8 NUM ct-10491 90 12 10 10 NUM ct-10491 90 13 12 12 NUM ct-10491 90 14 14 14 NUM ct-10491 90 15 16 16 NUM ct-10491 90 16 18 18 NUM ct-10491 90 17 20 20 NUM ct-10491 90 18 22 22 NUM ct-10491 90 19 24 24 NUM ct-10491 90 20 0.001 0.001 NUM ct-10491 90 21 0.01 0.01 NUM ct-10491 90 22 0.1 0.1 NUM ct-10491 90 23 1 1 NUM ct-10491 90 24 10 10 NUM ct-10491 90 25 ( ( PUNCT ct-10491 90 26 noitartnecnoc noitartnecnoc NOUN ct-10491 90 27 ) ) PUNCT ct-10491 91 1 l l NOUN ct-10491 91 2 m m PROPN ct-10491 91 3 / / SYM ct-10491 91 4 g g NOUN ct-10491 91 5 time time NOUN ct-10491 91 6 ( ( PUNCT ct-10491 91 7 hour hour NOUN ct-10491 91 8 ) ) PUNCT ct-10491 91 9 s s PART ct-10491 91 10 carprofen carprofen NOUN ct-10491 91 11 maternal maternal ADJ ct-10491 91 12 r r NOUN ct-10491 91 13 carprofen carprofen NOUN ct-10491 91 14 maternal maternal ADJ ct-10491 91 15 rs rs NOUN ct-10491 91 16 carprofen carprofen PROPN ct-10491 91 17 puppy puppy PROPN ct-10491 91 18 milk milk NOUN ct-10491 91 19 concentration concentration NOUN ct-10491 91 20 rs rs NOUN ct-10491 91 21 carprofen carprofen NOUN ct-10491 91 22 pup pup VERB ct-10491 91 23 r r NOUN ct-10491 91 24 carprofen carprofen PROPN ct-10491 91 25 maternal maternal PROPN ct-10491 91 26 s s PROPN ct-10491 91 27 carprofen carprofen PROPN ct-10491 91 28 maternal maternal PROPN ct-10491 91 29 µ µ X ct-10491 91 30 figure figure NOUN ct-10491 91 31 2 2 NUM ct-10491 91 32 . . PUNCT ct-10491 91 33 carprofen carprofen PROPN ct-10491 91 34 concentrations concentration NOUN ct-10491 91 35 in in ADP ct-10491 91 36 maternal maternal ADJ ct-10491 91 37 plasma plasma NOUN ct-10491 91 38 , , PUNCT ct-10491 91 39 maternal maternal ADJ ct-10491 91 40 milk milk NOUN ct-10491 91 41 , , PUNCT ct-10491 91 42 and and CCONJ ct-10491 91 43 pup pup VERB ct-10491 91 44 ’s ’s PART ct-10491 91 45 plasma plasma NOUN ct-10491 91 46 after after ADP ct-10491 91 47 a a DET ct-10491 91 48 single single ADJ ct-10491 91 49 intravenous intravenous ADJ ct-10491 91 50 carprofen carprofen NOUN ct-10491 91 51 ( ( PUNCT ct-10491 91 52 4.4 4.4 NUM ct-10491 91 53 mg mg PROPN ct-10491 91 54 / / SYM ct-10491 91 55 kg kg NOUN ct-10491 91 56 ) ) PUNCT ct-10491 91 57 treatment treatment NOUN ct-10491 91 58 to to ADP ct-10491 91 59 lactating lactate VERB ct-10491 91 60 dogs dog NOUN ct-10491 91 61 between between ADP ct-10491 91 62 days day NOUN ct-10491 91 63 16 16 NUM ct-10491 91 64 and and CCONJ ct-10491 91 65 24 24 NUM ct-10491 91 66 postpartum postpartum NOUN ct-10491 91 67 . . PUNCT ct-10491 92 1 table table NOUN ct-10491 92 2 . . PUNCT ct-10491 93 1 pharmacokinetic pharmacokinetic ADJ ct-10491 93 2 parameters parameter NOUN ct-10491 93 3 for for ADP ct-10491 93 4 carprofen carprofen PROPN ct-10491 93 5 r(- r(- PROPN ct-10491 93 6 ) ) PUNCT ct-10491 93 7 and and CCONJ ct-10491 93 8 s(+ s(+ NUM ct-10491 93 9 ) ) PUNCT ct-10491 93 10 enantiomers enantiomer NOUN ct-10491 93 11 of of ADP ct-10491 93 12 maternal maternal ADJ ct-10491 93 13 plasma plasma NOUN ct-10491 93 14 in in ADP ct-10491 93 15 a a DET ct-10491 93 16 2 2 NUM ct-10491 93 17 - - PUNCT ct-10491 93 18 compartment compartment NOUN ct-10491 93 19 model model NOUN ct-10491 93 20 in in ADP ct-10491 93 21 3 3 NUM ct-10491 93 22 dogs dog NOUN ct-10491 93 23 after after ADP ct-10491 93 24 an an DET ct-10491 93 25 intravenous intravenous ADJ ct-10491 93 26 dose dose NOUN ct-10491 93 27 of of ADP ct-10491 93 28 4.4 4.4 NUM ct-10491 93 29 mg mg PROPN ct-10491 93 30 / / SYM ct-10491 93 31 kg kg PROPN ct-10491 93 32 r(- r(- PROPN ct-10491 93 33 ) ) PUNCT ct-10491 93 34 enantiomer enantiomer NOUN ct-10491 93 35 s(+ s(+ NOUN ct-10491 93 36 ) ) PUNCT ct-10491 93 37 enantiomer enantiomer NOUN ct-10491 93 38 parameter parameter NOUN ct-10491 93 39 units unit NOUN ct-10491 93 40 median median ADJ ct-10491 93 41 range range NOUN ct-10491 93 42 median median PROPN ct-10491 93 43 range range NOUN ct-10491 93 44 a a DET ct-10491 93 45 µg µg NOUN ct-10491 93 46 / / SYM ct-10491 93 47 ml ml NOUN ct-10491 93 48 7.7 7.7 NUM ct-10491 93 49 ( ( PUNCT ct-10491 93 50 3.3 3.3 NUM ct-10491 93 51 - - SYM ct-10491 93 52 374.5 374.5 NUM ct-10491 93 53 ) ) PUNCT ct-10491 93 54 6.0 6.0 NUM ct-10491 93 55 ( ( PUNCT ct-10491 93 56 2.9 2.9 NUM ct-10491 93 57 - - SYM ct-10491 93 58 12.8 12.8 NUM ct-10491 93 59 ) ) PUNCT ct-10491 93 60 α α PRON ct-10491 93 61 1 1 NUM ct-10491 93 62 / / SYM ct-10491 93 63 hour hour NOUN ct-10491 93 64 1.2 1.2 NUM ct-10491 93 65 ( ( PUNCT ct-10491 93 66 0.8 0.8 NUM ct-10491 93 67 - - SYM ct-10491 93 68 11.3 11.3 NUM ct-10491 93 69 ) ) PUNCT ct-10491 93 70 0.7 0.7 NUM ct-10491 93 71 ( ( PUNCT ct-10491 93 72 0.4 0.4 NUM ct-10491 93 73 - - SYM ct-10491 93 74 1.3 1.3 NUM ct-10491 93 75 ) ) PUNCT ct-10491 93 76 b b NOUN ct-10491 93 77 µg µg ADJ ct-10491 93 78 / / SYM ct-10491 93 79 ml ml ADP ct-10491 93 80 1.4 1.4 NUM ct-10491 93 81 ( ( PUNCT ct-10491 93 82 0.3 0.3 NUM ct-10491 93 83 - - SYM ct-10491 93 84 3.1 3.1 NUM ct-10491 93 85 ) ) PUNCT ct-10491 93 86 3.0 3.0 NUM ct-10491 93 87 ( ( PUNCT ct-10491 93 88 1.3 1.3 NUM ct-10491 93 89 - - SYM ct-10491 93 90 3.1 3.1 NUM ct-10491 93 91 ) ) PUNCT ct-10491 93 92 β β NOUN ct-10491 93 93 1 1 NUM ct-10491 93 94 / / SYM ct-10491 93 95 hour hour NOUN ct-10491 93 96 0.1 0.1 NUM ct-10491 93 97 ( ( PUNCT ct-10491 93 98 0.1 0.1 NUM ct-10491 93 99 - - SYM ct-10491 93 100 0.2 0.2 NUM ct-10491 93 101 ) ) PUNCT ct-10491 93 102 0.1 0.1 NUM ct-10491 93 103 ( ( PUNCT ct-10491 93 104 0.1 0.1 NUM ct-10491 93 105 - - SYM ct-10491 93 106 0.1 0.1 NUM ct-10491 93 107 ) ) PUNCT ct-10491 93 108 αhl αhl NOUN ct-10491 93 109 hour hour NOUN ct-10491 93 110 0.6 0.6 NUM ct-10491 93 111 ( ( PUNCT ct-10491 93 112 0.1 0.1 NUM ct-10491 93 113 - - SYM ct-10491 93 114 0.8 0.8 NUM ct-10491 93 115 ) ) PUNCT ct-10491 93 116 1.0 1.0 NUM ct-10491 93 117 ( ( PUNCT ct-10491 93 118 0.5 0.5 NUM ct-10491 93 119 - - SYM ct-10491 93 120 1.6 1.6 NUM ct-10491 93 121 ) ) PUNCT ct-10491 93 122 βhl βhl NOUN ct-10491 93 123 hour hour NOUN ct-10491 93 124 6.8 6.8 NUM ct-10491 93 125 ( ( PUNCT ct-10491 93 126 4.0 4.0 NUM ct-10491 93 127 - - SYM ct-10491 93 128 12.6 12.6 NUM ct-10491 93 129 ) ) PUNCT ct-10491 93 130 6.2 6.2 NUM ct-10491 93 131 ( ( PUNCT ct-10491 93 132 5.2 5.2 NUM ct-10491 93 133 - - SYM ct-10491 93 134 6.8 6.8 NUM ct-10491 93 135 ) ) PUNCT ct-10491 93 136 auc auc NOUN ct-10491 93 137 hour*µg hour*µg NOUN ct-10491 93 138 / / SYM ct-10491 93 139 ml ml PROPN ct-10491 93 140 23.0 23.0 NUM ct-10491 93 141 ( ( PUNCT ct-10491 93 142 7.5 7.5 NUM ct-10491 93 143 - - SYM ct-10491 93 144 51.5 51.5 NUM ct-10491 93 145 ) ) PUNCT ct-10491 93 146 29.8 29.8 NUM ct-10491 93 147 ( ( PUNCT ct-10491 93 148 15.9 15.9 NUM ct-10491 93 149 - - SYM ct-10491 93 150 47.9 47.9 NUM ct-10491 93 151 ) ) PUNCT ct-10491 93 152 aumc aumc NOUN ct-10491 93 153 hour*µg hour*µg NOUN ct-10491 93 154 / / SYM ct-10491 93 155 ml ml PROPN ct-10491 93 156 106.5 106.5 NUM ct-10491 93 157 ( ( PUNCT ct-10491 93 158 86.4 86.4 NUM ct-10491 93 159 - - SYM ct-10491 93 160 147.2 147.2 NUM ct-10491 93 161 ) ) PUNCT ct-10491 93 162 192.3 192.3 NUM ct-10491 93 163 ( ( PUNCT ct-10491 93 164 105.4 105.4 NUM ct-10491 93 165 - - SYM ct-10491 93 166 311.7 311.7 NUM ct-10491 93 167 ) ) PUNCT ct-10491 93 168 cl cl NOUN ct-10491 93 169 ml ml ADP ct-10491 93 170 / / SYM ct-10491 93 171 hr hr NOUN ct-10491 93 172 / / SYM ct-10491 93 173 kg kg PROPN ct-10491 93 174 95.8 95.8 NUM ct-10491 93 175 ( ( PUNCT ct-10491 93 176 43.0 43.0 NUM ct-10491 93 177 - - SYM ct-10491 93 178 292.9 292.9 NUM ct-10491 93 179 ) ) PUNCT ct-10491 93 180 73.9 73.9 NUM ct-10491 93 181 ( ( PUNCT ct-10491 93 182 46.0 46.0 NUM ct-10491 93 183 - - SYM ct-10491 93 184 138.7 138.7 NUM ct-10491 93 185 ) ) PUNCT ct-10491 93 186 cmax cmax NOUN ct-10491 93 187 µg µg ADV ct-10491 93 188 / / SYM ct-10491 93 189 ml ml ADP ct-10491 93 190 9.1 9.1 NUM ct-10491 93 191 ( ( PUNCT ct-10491 93 192 3.6 3.6 NUM ct-10491 93 193 - - SYM ct-10491 93 194 377.6 377.6 NUM ct-10491 93 195 ) ) PUNCT ct-10491 93 196 7.3 7.3 NUM ct-10491 93 197 ( ( PUNCT ct-10491 93 198 5.8 5.8 NUM ct-10491 93 199 - - SYM ct-10491 93 200 15.7 15.7 NUM ct-10491 93 201 ) ) PUNCT ct-10491 93 202 k10 k10 NOUN ct-10491 93 203 1 1 NUM ct-10491 93 204 / / SYM ct-10491 93 205 hour hour NOUN ct-10491 93 206 0.5 0.5 NUM ct-10491 93 207 ( ( PUNCT ct-10491 93 208 0.4 0.4 NUM ct-10491 93 209 - - SYM ct-10491 93 210 7.4 7.4 NUM ct-10491 93 211 ) ) PUNCT ct-10491 93 212 0.3 0.3 NUM ct-10491 93 213 ( ( PUNCT ct-10491 93 214 0.2 0.2 NUM ct-10491 93 215 - - PUNCT ct-10491 93 216 0.5 0.5 NUM ct-10491 93 217 ) ) PUNCT ct-10491 93 218 k12 k12 NOUN ct-10491 93 219 1 1 NUM ct-10491 93 220 / / SYM ct-10491 93 221 hour hour NOUN ct-10491 93 222 0.6 0.6 NUM ct-10491 93 223 ( ( PUNCT ct-10491 93 224 0.3 0.3 NUM ct-10491 93 225 - - SYM ct-10491 93 226 3.8 3.8 NUM ct-10491 93 227 ) ) PUNCT ct-10491 93 228 0.2 0.2 NUM ct-10491 93 229 ( ( PUNCT ct-10491 93 230 0.1 0.1 NUM ct-10491 93 231 - - SYM ct-10491 93 232 0.7 0.7 NUM ct-10491 93 233 ) ) PUNCT ct-10491 93 234 k21 k21 NOUN ct-10491 93 235 1 1 NUM ct-10491 93 236 / / SYM ct-10491 93 237 hour hour NOUN ct-10491 93 238 0.2 0.2 NUM ct-10491 93 239 ( ( PUNCT ct-10491 93 240 0.1 0.1 NUM ct-10491 93 241 - - SYM ct-10491 93 242 0.3 0.3 NUM ct-10491 93 243 ) ) PUNCT ct-10491 93 244 0.3 0.3 NUM ct-10491 93 245 ( ( PUNCT ct-10491 93 246 0.2 0.2 NUM ct-10491 93 247 - - PUNCT ct-10491 93 248 0.3 0.3 NUM ct-10491 93 249 ) ) PUNCT ct-10491 93 250 mrt mrt PROPN ct-10491 93 251 hour hour NOUN ct-10491 93 252 6.4 6.4 NUM ct-10491 93 253 ( ( PUNCT ct-10491 93 254 2.1 2.1 NUM ct-10491 93 255 - - SYM ct-10491 93 256 11.5 11.5 NUM ct-10491 93 257 ) ) PUNCT ct-10491 93 258 6.5 6.5 NUM ct-10491 93 259 ( ( PUNCT ct-10491 93 260 6.5 6.5 NUM ct-10491 93 261 - - SYM ct-10491 93 262 6.7 6.7 NUM ct-10491 93 263 ) ) PUNCT ct-10491 93 264 v1 v1 NOUN ct-10491 93 265 ml ml ADP ct-10491 93 266 / / SYM ct-10491 93 267 kg kg PROPN ct-10491 93 268 242.1 242.1 NUM ct-10491 93 269 ( ( PUNCT ct-10491 93 270 5.8 5.8 NUM ct-10491 93 271 - - SYM ct-10491 93 272 611.8 611.8 NUM ct-10491 93 273 ) ) PUNCT ct-10491 93 274 301.3 301.3 NUM ct-10491 93 275 ( ( PUNCT ct-10491 93 276 139.8 139.8 NUM ct-10491 93 277 - - SYM ct-10491 93 278 378.0 378.0 NUM ct-10491 93 279 ) ) PUNCT ct-10491 93 280 a a PRON ct-10491 93 281 and and CCONJ ct-10491 93 282 b b NOUN ct-10491 93 283 : : PUNCT ct-10491 93 284 y y ADJ ct-10491 93 285 - - PUNCT ct-10491 93 286 axis axis NOUN ct-10491 93 287 intercepts intercept NOUN ct-10491 93 288 for for ADP ct-10491 93 289 the the DET ct-10491 93 290 phases phase NOUN ct-10491 93 291 of of ADP ct-10491 93 292 distribution distribution NOUN ct-10491 93 293 and and CCONJ ct-10491 93 294 elimination elimination NOUN ct-10491 93 295 ; ; PUNCT ct-10491 93 296 α α NOUN ct-10491 93 297 and and CCONJ ct-10491 93 298 β β ADJ ct-10491 93 299 : : PUNCT ct-10491 93 300 fractional fractional ADJ ct-10491 93 301 elimination elimination NOUN ct-10491 93 302 rate rate NOUN ct-10491 93 303 constants constant NOUN ct-10491 93 304 ; ; PUNCT ct-10491 93 305 k10 k10 PROPN ct-10491 93 306 , , PUNCT ct-10491 93 307 k12 k12 PROPN ct-10491 93 308 , , PUNCT ct-10491 93 309 k21 k21 PROPN ct-10491 93 310 : : PUNCT ct-10491 93 311 elimination elimination NOUN ct-10491 93 312 and and CCONJ ct-10491 93 313 compartmental compartmental ADJ ct-10491 93 314 rate rate NOUN ct-10491 93 315 constants constant NOUN ct-10491 93 316 ; ; PUNCT ct-10491 94 1 mrt mrt NOUN ct-10491 94 2 : : PUNCT ct-10491 94 3 mean mean VERB ct-10491 94 4 residence residence NOUN ct-10491 94 5 time time NOUN ct-10491 94 6 ; ; PUNCT ct-10491 94 7 k10 k10 PROPN ct-10491 94 8 hl hl NOUN ct-10491 94 9 : : PUNCT ct-10491 94 10 elimination elimination NOUN ct-10491 94 11 half half ADJ ct-10491 94 12 - - PUNCT ct-10491 94 13 life life NOUN ct-10491 94 14 ; ; PUNCT ct-10491 94 15 α α X ct-10491 94 16 - - PUNCT ct-10491 94 17 hl hl NOUN ct-10491 94 18 : : PUNCT ct-10491 94 19 distribution distribution NOUN ct-10491 94 20 half half ADJ ct-10491 94 21 - - PUNCT ct-10491 94 22 life life NOUN ct-10491 94 23 ; ; PUNCT ct-10491 94 24 β β X ct-10491 94 25 - - PUNCT ct-10491 94 26 hl hl NOUN ct-10491 94 27 : : PUNCT ct-10491 94 28 terminal terminal ADJ ct-10491 94 29 half half ADJ ct-10491 94 30 - - PUNCT ct-10491 94 31 life life NOUN ct-10491 94 32 ; ; PUNCT ct-10491 94 33 auc auc NOUN ct-10491 94 34 , , PUNCT ct-10491 94 35 area area NOUN ct-10491 94 36 - - PUNCT ct-10491 94 37 under under ADP ct-10491 94 38 - - PUNCT ct-10491 94 39 the the DET ct-10491 94 40 - - PUNCT ct-10491 94 41 curve curve NOUN ct-10491 94 42 ; ; PUNCT ct-10491 94 43 v1 v1 NOUN ct-10491 94 44 , , PUNCT ct-10491 94 45 volume volume NOUN ct-10491 94 46 of of ADP ct-10491 94 47 the the DET ct-10491 94 48 central central ADJ ct-10491 94 49 compartment compartment NOUN ct-10491 94 50 ; ; PUNCT ct-10491 94 51 cl cl NOUN ct-10491 94 52 , , PUNCT ct-10491 94 53 total total ADJ ct-10491 94 54 plasma plasma NOUN ct-10491 94 55 clearance clearance NOUN ct-10491 94 56 . . PUNCT ct-10491 95 1 estimates estimate NOUN ct-10491 95 2 are be AUX ct-10491 95 3 based base VERB ct-10491 95 4 on on ADP ct-10491 95 5 a a DET ct-10491 95 6 2 2 NUM ct-10491 95 7 - - PUNCT ct-10491 95 8 compartment compartment NOUN ct-10491 95 9 model model NOUN ct-10491 95 10 . . PUNCT ct-10491 96 1 http://dx.doi.org/10.58292/ct.v16.10491 http://dx.doi.org/10.58292/ct.v16.10491 NOUN ct-10491 96 2 citation citation NOUN ct-10491 96 3 : : PUNCT ct-10491 96 4 clinical clinical ADJ ct-10491 96 5 theriogenology theriogenology NOUN ct-10491 96 6 2024 2024 NUM ct-10491 96 7 , , PUNCT ct-10491 96 8 16 16 NUM ct-10491 96 9 , , PUNCT ct-10491 96 10 10491 10491 NUM ct-10491 96 11 , , PUNCT ct-10491 96 12 http://dx.doi.org/10.58292/ct.v16.10491 http://dx.doi.org/10.58292/ct.v16.10491 NOUN ct-10491 96 13 5 5 NUM ct-10491 96 14 pharmacokinetics pharmacokinetic NOUN ct-10491 96 15 for for ADP ct-10491 96 16 all all DET ct-10491 96 17 testing testing NOUN ct-10491 96 18 groups group NOUN ct-10491 96 19 , , PUNCT ct-10491 96 20 these these DET ct-10491 96 21 results result NOUN ct-10491 96 22 supported support VERB ct-10491 96 23 our our PRON ct-10491 96 24 hypothesis hypothesis NOUN ct-10491 96 25 that that PRON ct-10491 96 26 carprofen carprofen PROPN ct-10491 96 27 is be AUX ct-10491 96 28 safe safe ADJ ct-10491 96 29 to to PART ct-10491 96 30 treat treat VERB ct-10491 96 31 lactating lactate VERB ct-10491 96 32 dogs dog NOUN ct-10491 96 33 because because SCONJ ct-10491 96 34 there there PRON ct-10491 96 35 is be VERB ct-10491 96 36 low low ADV ct-10491 96 37 observed observed ADJ ct-10491 96 38 milk milk NOUN ct-10491 96 39 concentrations concentration NOUN ct-10491 96 40 and and CCONJ ct-10491 96 41 negligible negligible ADJ ct-10491 96 42 risk risk NOUN ct-10491 96 43 to to ADP ct-10491 96 44 pups pup NOUN ct-10491 96 45 . . PUNCT ct-10491 97 1 concentrations concentration NOUN ct-10491 97 2 of of ADP ct-10491 97 3 carprofen carprofen PROPN ct-10491 97 4 in in ADP ct-10491 97 5 the the DET ct-10491 97 6 maternal maternal ADJ ct-10491 97 7 plasma plasma NOUN ct-10491 97 8 of of ADP ct-10491 97 9 lactating lactate VERB ct-10491 97 10 dogs dog NOUN ct-10491 97 11 were be AUX ct-10491 97 12 below below ADP ct-10491 97 13 the the DET ct-10491 97 14 lod lod NOUN ct-10491 97 15 by by ADP ct-10491 97 16 24 24 NUM ct-10491 97 17 hours hour NOUN ct-10491 97 18 that that PRON ct-10491 97 19 was be AUX ct-10491 97 20 expected expect VERB ct-10491 97 21 for for ADP ct-10491 97 22 the the DET ct-10491 97 23 dose dose NOUN ct-10491 97 24 ( ( PUNCT ct-10491 97 25 for for ADP ct-10491 97 26 24 24 NUM ct-10491 97 27 hours hour NOUN ct-10491 97 28 at at ADP ct-10491 97 29 4.4 4.4 NUM ct-10491 97 30 mg mg PROPN ct-10491 97 31 / / SYM ct-10491 97 32 kg kg NOUN ct-10491 97 33 ) ) PUNCT ct-10491 97 34 given give VERB ct-10491 97 35 and and CCONJ ct-10491 97 36 comparable comparable ADJ ct-10491 97 37 to to ADP ct-10491 97 38 studies study NOUN ct-10491 97 39 in in ADP ct-10491 97 40 healthy healthy ADJ ct-10491 97 41 ( ( PUNCT ct-10491 97 42 intravenous intravenous ADJ ct-10491 97 43 , , PUNCT ct-10491 97 44 subcutaneous subcutaneous ADJ ct-10491 97 45 , , PUNCT ct-10491 97 46 and and CCONJ ct-10491 97 47 oral oral ADJ ct-10491 97 48 routes route NOUN ct-10491 97 49 ) ) PUNCT ct-10491 97 50 and and CCONJ ct-10491 97 51 pain pain NOUN ct-10491 97 52 - - PUNCT ct-10491 97 53 induced induce VERB ct-10491 97 54 ( ( PUNCT ct-10491 97 55 subcutaneous subcutaneous ADJ ct-10491 97 56 and and CCONJ ct-10491 97 57 oral oral ADJ ct-10491 97 58 routes route NOUN ct-10491 97 59 ) ) PUNCT ct-10491 97 60 dogs.1,14,15,33 dogs.1,14,15,33 NOUN ct-10491 97 61 plasma plasma NOUN ct-10491 97 62 concentrations concentration NOUN ct-10491 97 63 in in ADP ct-10491 97 64 lactating lactate VERB ct-10491 97 65 dogs dog NOUN ct-10491 97 66 were be AUX ct-10491 97 67 different different ADJ ct-10491 97 68 than than SCONJ ct-10491 97 69 published publish VERB ct-10491 97 70 for for ADP ct-10491 97 71 nonlactating nonlactate VERB ct-10491 97 72 dogs dog NOUN ct-10491 97 73 in in ADP ct-10491 97 74 both both CCONJ ct-10491 97 75 enantiomers.1,10,14 enantiomers.1,10,14 ADV ct-10491 97 76 the the DET ct-10491 97 77 major major ADJ ct-10491 97 78 differences difference NOUN ct-10491 97 79 observed observe VERB ct-10491 97 80 between between ADP ct-10491 97 81 our our PRON ct-10491 97 82 results result NOUN ct-10491 97 83 and and CCONJ ct-10491 97 84 earlier early ADJ ct-10491 97 85 studies study NOUN ct-10491 97 86 were be AUX ct-10491 97 87 higher high ADJ ct-10491 97 88 clearance clearance NOUN ct-10491 97 89 rates rate NOUN ct-10491 97 90 and and CCONJ ct-10491 97 91 volumes volume NOUN ct-10491 97 92 of of ADP ct-10491 97 93 distribution distribution NOUN ct-10491 97 94 and and CCONJ ct-10491 97 95 lower low ADJ ct-10491 97 96 aucs aucs NOUN ct-10491 97 97 . . PUNCT ct-10491 98 1 the the DET ct-10491 98 2 maximum maximum ADJ ct-10491 98 3 concentration concentration NOUN ct-10491 98 4 , , PUNCT ct-10491 98 5 movement movement NOUN ct-10491 98 6 between between ADP ct-10491 98 7 both both PRON ct-10491 98 8 compartments compartment NOUN ct-10491 98 9 and and CCONJ ct-10491 98 10 elimination elimination NOUN ct-10491 98 11 rates rate NOUN ct-10491 98 12 were be AUX ct-10491 98 13 similar similar ADJ ct-10491 98 14 . . PUNCT ct-10491 99 1 reasons reason NOUN ct-10491 99 2 for for ADP ct-10491 99 3 these these DET ct-10491 99 4 differences difference NOUN ct-10491 99 5 are be AUX ct-10491 99 6 undetermined undetermined ADJ ct-10491 99 7 , , PUNCT ct-10491 99 8 but but CCONJ ct-10491 99 9 it it PRON ct-10491 99 10 may may AUX ct-10491 99 11 be be AUX ct-10491 99 12 due due ADJ ct-10491 99 13 to to ADP ct-10491 99 14 higher high ADJ ct-10491 99 15 plasma plasma NOUN ct-10491 99 16 volume volume NOUN ct-10491 99 17 during during ADP ct-10491 99 18 lactation lactation NOUN ct-10491 99 19 and and CCONJ ct-10491 99 20 underlying underlying ADJ ct-10491 99 21 physiological physiological ADJ ct-10491 99 22 inflammation inflammation NOUN ct-10491 99 23 associated associate VERB ct-10491 99 24 with with ADP ct-10491 99 25 uterine uterine ADJ ct-10491 99 26 involution.34 involution.34 NOUN ct-10491 99 27 changes change NOUN ct-10491 99 28 in in ADP ct-10491 99 29 plasma plasma NOUN ct-10491 99 30 volume volume NOUN ct-10491 99 31 have have AUX ct-10491 99 32 been be AUX ct-10491 99 33 documented document VERB ct-10491 99 34 to to PART ct-10491 99 35 increase increase VERB ct-10491 99 36 by by ADP ct-10491 99 37 23 23 NUM ct-10491 99 38 % % NOUN ct-10491 99 39 in in ADP ct-10491 99 40 lactation lactation NOUN ct-10491 99 41 for for ADP ct-10491 99 42 sheep35 sheep35 NOUN ct-10491 99 43 and and CCONJ ct-10491 99 44 45 45 NUM ct-10491 99 45 % % NOUN ct-10491 99 46 in in ADP ct-10491 99 47 pregnant pregnant ADJ ct-10491 99 48 women.32 women.32 NOUN ct-10491 99 49 in in ADP ct-10491 99 50 women woman NOUN ct-10491 99 51 , , PUNCT ct-10491 99 52 plasma plasma NOUN ct-10491 99 53 concentrations concentration NOUN ct-10491 99 54 of of ADP ct-10491 99 55 some some DET ct-10491 99 56 drugs drug NOUN ct-10491 99 57 have have AUX ct-10491 99 58 been be AUX ct-10491 99 59 reported report VERB ct-10491 99 60 to to PART ct-10491 99 61 change change VERB ct-10491 99 62 during during ADP ct-10491 99 63 pregnancy pregnancy NOUN ct-10491 99 64 and and CCONJ ct-10491 99 65 albumin albumin ADJ ct-10491 99 66 concentrations concentration NOUN ct-10491 99 67 undergo undergo VERB ct-10491 99 68 a a DET ct-10491 99 69 steady steady ADJ ct-10491 99 70 decline decline NOUN ct-10491 99 71 to to ADP ct-10491 99 72 ~ ~ PUNCT ct-10491 99 73 70 70 NUM ct-10491 99 74 - - SYM ct-10491 99 75 80 80 NUM ct-10491 99 76 % % NOUN ct-10491 99 77 of of ADP ct-10491 99 78 normal normal ADJ ct-10491 99 79 values value NOUN ct-10491 99 80 at at ADP ct-10491 99 81 the the DET ct-10491 99 82 time time NOUN ct-10491 99 83 of of ADP ct-10491 99 84 delivery.32 delivery.32 NOUN ct-10491 99 85 when when SCONJ ct-10491 99 86 albumin albumin ADJ ct-10491 99 87 concentrations concentration NOUN ct-10491 99 88 decreased decrease VERB ct-10491 99 89 , , PUNCT ct-10491 99 90 there there PRON ct-10491 99 91 is be VERB ct-10491 99 92 a a DET ct-10491 99 93 significant significant ADJ ct-10491 99 94 increase increase NOUN ct-10491 99 95 in in ADP ct-10491 99 96 the the DET ct-10491 99 97 auc auc NOUN ct-10491 99 98 of of ADP ct-10491 99 99 unbound unbound NOUN ct-10491 99 100 drugs drug NOUN ct-10491 99 101 that that PRON ct-10491 99 102 can can AUX ct-10491 99 103 increase increase VERB ct-10491 99 104 the the DET ct-10491 99 105 pharmacological pharmacological ADJ ct-10491 99 106 effect effect NOUN ct-10491 99 107 . . PUNCT ct-10491 100 1 in in ADP ct-10491 100 2 addition addition NOUN ct-10491 100 3 , , PUNCT ct-10491 100 4 estradiol estradiol PROPN ct-10491 100 5 and and CCONJ ct-10491 100 6 progesterone progesterone VERB ct-10491 100 7 increased increase VERB ct-10491 100 8 hepatic hepatic ADJ ct-10491 100 9 metabolism metabolism NOUN ct-10491 100 10 via via ADP ct-10491 100 11 xenobiotics xenobiotic NOUN ct-10491 100 12 as as ADV ct-10491 100 13 well well ADV ct-10491 100 14 as as ADP ct-10491 100 15 cy cy PROPN ct-10491 100 16 - - PUNCT ct-10491 100 17 p450 p450 PROPN ct-10491 100 18 enzyme enzyme NOUN ct-10491 100 19 activity.32 activity.32 NOUN ct-10491 100 20 evidence evidence NOUN ct-10491 100 21 suggested suggest VERB ct-10491 100 22 that that SCONJ ct-10491 100 23 an an DET ct-10491 100 24 increased increase VERB ct-10491 100 25 clearance clearance NOUN ct-10491 100 26 and and CCONJ ct-10491 100 27 decreased decrease VERB ct-10491 100 28 concentrations concentration NOUN ct-10491 100 29 of of ADP ct-10491 100 30 some some DET ct-10491 100 31 drugs drug NOUN ct-10491 100 32 may may AUX ct-10491 100 33 be be AUX ct-10491 100 34 the the DET ct-10491 100 35 results result NOUN ct-10491 100 36 of of ADP ct-10491 100 37 these these DET ct-10491 100 38 physiologic physiologic ADJ ct-10491 100 39 changes.32 changes.32 NOUN ct-10491 100 40 only only ADV ct-10491 100 41 a a DET ct-10491 100 42 few few ADJ ct-10491 100 43 studies study NOUN ct-10491 100 44 described describe VERB ct-10491 100 45 physiological physiological ADJ ct-10491 100 46 changes change NOUN ct-10491 100 47 that that PRON ct-10491 100 48 occur occur VERB ct-10491 100 49 during during ADP ct-10491 100 50 canine canine ADJ ct-10491 100 51 pregnancy pregnancy NOUN ct-10491 100 52 with with ADP ct-10491 100 53 limited limited ADJ ct-10491 100 54 studies study NOUN ct-10491 100 55 during during ADP ct-10491 100 56 lactation lactation NOUN ct-10491 100 57 . . PUNCT ct-10491 101 1 most most ADV ct-10491 101 2 reported report VERB ct-10491 101 3 hematologic hematologic NOUN ct-10491 101 4 and and CCONJ ct-10491 101 5 serum serum VERB ct-10491 101 6 biochemical biochemical ADJ ct-10491 101 7 differences difference NOUN ct-10491 101 8 in in ADP ct-10491 101 9 pregnant pregnant ADJ ct-10491 101 10 versus versus ADP ct-10491 101 11 nonpregnant nonpregnant ADJ ct-10491 101 12 dogs dog NOUN ct-10491 101 13 having have VERB ct-10491 101 14 anemia anemia NOUN ct-10491 101 15 , , PUNCT ct-10491 101 16 thrombocytosis thrombocytosis NOUN ct-10491 101 17 , , PUNCT ct-10491 101 18 leukocytosis leukocytosis NOUN ct-10491 101 19 , , PUNCT ct-10491 101 20 hypoalbuminemia hypoalbuminemia NOUN ct-10491 101 21 , , PUNCT ct-10491 101 22 hypoproteinemia hypoproteinemia NOUN ct-10491 101 23 , , PUNCT ct-10491 101 24 and and CCONJ ct-10491 101 25 changes change NOUN ct-10491 101 26 in in ADP ct-10491 101 27 cholesterol cholesterol NOUN ct-10491 101 28 amongst amongst ADP ct-10491 101 29 other other ADJ ct-10491 101 30 findings finding NOUN ct-10491 101 31 in in ADP ct-10491 101 32 late late ADJ ct-10491 101 33 pregnancy.31 pregnancy.31 NOUN ct-10491 101 34 an an DET ct-10491 101 35 increase increase NOUN ct-10491 101 36 in in ADP ct-10491 101 37 plasma plasma NOUN ct-10491 101 38 volume volume NOUN ct-10491 101 39 during during ADP ct-10491 101 40 pregnancy pregnancy NOUN ct-10491 101 41 in in ADP ct-10491 101 42 dogs dog NOUN ct-10491 101 43 has have AUX ct-10491 101 44 been be AUX ct-10491 101 45 noted,36 noted,36 NUM ct-10491 101 46 but but CCONJ ct-10491 101 47 an an DET ct-10491 101 48 exact exact ADJ ct-10491 101 49 percentage percentage NOUN ct-10491 101 50 increase increase NOUN ct-10491 101 51 has have AUX ct-10491 101 52 not not PART ct-10491 101 53 been be AUX ct-10491 101 54 calculated calculate VERB ct-10491 101 55 to to ADP ct-10491 101 56 the the DET ct-10491 101 57 authors author NOUN ct-10491 101 58 ’ ’ PART ct-10491 101 59 knowledge knowledge NOUN ct-10491 101 60 . . PUNCT ct-10491 102 1 with with ADP ct-10491 102 2 this this DET ct-10491 102 3 increase increase NOUN ct-10491 102 4 in in ADP ct-10491 102 5 plasma plasma NOUN ct-10491 102 6 volume volume NOUN ct-10491 102 7 , , PUNCT ct-10491 102 8 increased increase VERB ct-10491 102 9 renal renal ADJ ct-10491 102 10 blood blood NOUN ct-10491 102 11 flow flow NOUN ct-10491 102 12 and and CCONJ ct-10491 102 13 glomerular glomerular ADJ ct-10491 102 14 filtration filtration NOUN ct-10491 102 15 rate rate NOUN ct-10491 102 16 have have AUX ct-10491 102 17 been be AUX ct-10491 102 18 observed.37 observed.37 ADJ ct-10491 102 19 we we PRON ct-10491 102 20 theorized theorize VERB ct-10491 102 21 that that SCONJ ct-10491 102 22 changes change NOUN ct-10491 102 23 in in ADP ct-10491 102 24 women woman NOUN ct-10491 102 25 and and CCONJ ct-10491 102 26 other other ADJ ct-10491 102 27 species specie NOUN ct-10491 102 28 in in ADP ct-10491 102 29 pregnancy pregnancy NOUN ct-10491 102 30 and and CCONJ ct-10491 102 31 lactation lactation NOUN ct-10491 102 32 are be AUX ct-10491 102 33 similar similar ADJ ct-10491 102 34 in in ADP ct-10491 102 35 dogs dog NOUN ct-10491 102 36 and and CCONJ ct-10491 102 37 can can AUX ct-10491 102 38 explain explain VERB ct-10491 102 39 our our PRON ct-10491 102 40 observations observation NOUN ct-10491 102 41 . . PUNCT ct-10491 103 1 the the DET ct-10491 103 2 low low ADJ ct-10491 103 3 detection detection NOUN ct-10491 103 4 of of ADP ct-10491 103 5 carprofen carprofen NOUN ct-10491 103 6 in in ADP ct-10491 103 7 the the DET ct-10491 103 8 milk milk NOUN ct-10491 103 9 in in ADP ct-10491 103 10 our our PRON ct-10491 103 11 study study NOUN ct-10491 103 12 was be AUX ct-10491 103 13 consistent consistent ADJ ct-10491 103 14 with with ADP ct-10491 103 15 our our PRON ct-10491 103 16 predictions prediction NOUN ct-10491 103 17 of of ADP ct-10491 103 18 low low ADJ ct-10491 103 19 transfer transfer NOUN ct-10491 103 20 from from ADP ct-10491 103 21 mother mother NOUN ct-10491 103 22 to to ADP ct-10491 103 23 milk milk NOUN ct-10491 103 24 , , PUNCT ct-10491 103 25 due due ADP ct-10491 103 26 to to ADP ct-10491 103 27 the the DET ct-10491 103 28 partition partition NOUN ct-10491 103 29 theory theory NOUN ct-10491 103 30 as as ADV ct-10491 103 31 well well ADV ct-10491 103 32 as as ADP ct-10491 103 33 carprofen carprofen PROPN ct-10491 103 34 ’s ’s PART ct-10491 103 35 high high ADJ ct-10491 103 36 percentage percentage NOUN ct-10491 103 37 of of ADP ct-10491 103 38 protein protein NOUN ct-10491 103 39 binding bind VERB ct-10491 103 40 in in ADP ct-10491 103 41 the the DET ct-10491 103 42 plasma plasma NOUN ct-10491 103 43 ( ( PUNCT ct-10491 103 44 > > X ct-10491 103 45 98%),1 98%),1 NUM ct-10491 103 46 most most ADJ ct-10491 103 47 of of ADP ct-10491 103 48 which which PRON ct-10491 103 49 is be AUX ct-10491 103 50 bound bind VERB ct-10491 103 51 to to ADP ct-10491 103 52 albumin albumin NOUN ct-10491 103 53 . . PUNCT ct-10491 104 1 the the DET ct-10491 104 2 single single ADJ ct-10491 104 3 milk milk NOUN ct-10491 104 4 sample sample NOUN ct-10491 104 5 with with ADP ct-10491 104 6 concentrations concentration NOUN ct-10491 104 7 above above ADP ct-10491 104 8 the the DET ct-10491 104 9 loq loq PROPN ct-10491 104 10 occurred occur VERB ct-10491 104 11 at at ADP ct-10491 104 12 12 12 NUM ct-10491 104 13 hours hour NOUN ct-10491 104 14 after after ADP ct-10491 104 15 treatment treatment NOUN ct-10491 104 16 in in ADP ct-10491 104 17 dog dog NOUN ct-10491 104 18 1 1 NUM ct-10491 104 19 coinciding coincide VERB ct-10491 104 20 with with ADP ct-10491 104 21 litter litter NOUN ct-10491 104 22 1 1 NUM ct-10491 104 23 which which PRON ct-10491 104 24 measured measure VERB ct-10491 104 25 above above ADP ct-10491 104 26 the the DET ct-10491 104 27 loq loq PROPN ct-10491 104 28 at at ADP ct-10491 104 29 that that DET ct-10491 104 30 timepoint timepoint NOUN ct-10491 104 31 as as ADV ct-10491 104 32 well well ADV ct-10491 104 33 . . PUNCT ct-10491 105 1 this this DET ct-10491 105 2 mother mother NOUN ct-10491 105 3 was be AUX ct-10491 105 4 the the DET ct-10491 105 5 heaviest heavy ADJ ct-10491 105 6 dog dog NOUN ct-10491 105 7 ( ( PUNCT ct-10491 105 8 23.3 23.3 NUM ct-10491 105 9 kg kg NOUN ct-10491 105 10 ) ) PUNCT ct-10491 105 11 in in ADP ct-10491 105 12 our our PRON ct-10491 105 13 study study NOUN ct-10491 105 14 ; ; PUNCT ct-10491 105 15 she she PRON ct-10491 105 16 was be AUX ct-10491 105 17 also also ADV ct-10491 105 18 the the DET ct-10491 105 19 oldest old ADJ ct-10491 105 20 and and CCONJ ct-10491 105 21 one one NUM ct-10491 105 22 of of ADP ct-10491 105 23 the the DET ct-10491 105 24 better well ADJ ct-10491 105 25 milk milk NOUN ct-10491 105 26 producers producer NOUN ct-10491 105 27 in in ADP ct-10491 105 28 the the DET ct-10491 105 29 kennel kennel NOUN ct-10491 105 30 having having AUX ct-10491 105 31 raised raise VERB ct-10491 105 32 several several ADJ ct-10491 105 33 litters litter NOUN ct-10491 105 34 ( ( PUNCT ct-10491 105 35 exact exact ADJ ct-10491 105 36 number number NOUN ct-10491 105 37 unknown unknown NOUN ct-10491 105 38 ) ) PUNCT ct-10491 105 39 . . PUNCT ct-10491 106 1 she she PRON ct-10491 106 2 was be AUX ct-10491 106 3 of of ADP ct-10491 106 4 similar similar ADJ ct-10491 106 5 lactation lactation NOUN ct-10491 106 6 stage stage NOUN ct-10491 106 7 as as ADP ct-10491 106 8 the the DET ct-10491 106 9 other other ADJ ct-10491 106 10 dogs dog NOUN ct-10491 106 11 at at ADP ct-10491 106 12 22 22 NUM ct-10491 106 13 days day NOUN ct-10491 106 14 into into ADP ct-10491 106 15 milk milk NOUN ct-10491 106 16 with with ADP ct-10491 106 17 a a DET ct-10491 106 18 similar similar ADJ ct-10491 106 19 litter litter NOUN ct-10491 106 20 size size NOUN ct-10491 106 21 of of ADP ct-10491 106 22 7 7 NUM ct-10491 106 23 pups pup NOUN ct-10491 106 24 . . PUNCT ct-10491 107 1 without without ADP ct-10491 107 2 further further ADJ ct-10491 107 3 investigation investigation NOUN ct-10491 107 4 , , PUNCT ct-10491 107 5 we we PRON ct-10491 107 6 can can AUX ct-10491 107 7 not not PART ct-10491 107 8 speculate speculate VERB ct-10491 107 9 if if SCONJ ct-10491 107 10 dog dog NOUN ct-10491 107 11 size size NOUN ct-10491 107 12 and/or and/or CCONJ ct-10491 107 13 milk milk NOUN ct-10491 107 14 production production NOUN ct-10491 107 15 alone alone ADV ct-10491 107 16 contributes contribute VERB ct-10491 107 17 to to ADP ct-10491 107 18 the the DET ct-10491 107 19 extent extent NOUN ct-10491 107 20 of of ADP ct-10491 107 21 disposition disposition NOUN ct-10491 107 22 of of ADP ct-10491 107 23 carprofen carprofen NOUN ct-10491 107 24 in in ADP ct-10491 107 25 milk milk NOUN ct-10491 107 26 and and CCONJ ct-10491 107 27 pup pup VERB ct-10491 107 28 exposure exposure NOUN ct-10491 107 29 . . PUNCT ct-10491 108 1 we we PRON ct-10491 108 2 were be AUX ct-10491 108 3 not not PART ct-10491 108 4 able able ADJ ct-10491 108 5 to to PART ct-10491 108 6 accurately accurately ADV ct-10491 108 7 measure measure VERB ct-10491 108 8 total total ADJ ct-10491 108 9 milk milk NOUN ct-10491 108 10 ingestion ingestion NOUN ct-10491 108 11 in in ADP ct-10491 108 12 pups pup NOUN ct-10491 108 13 nor nor CCONJ ct-10491 108 14 daily daily ADJ ct-10491 108 15 milk milk NOUN ct-10491 108 16 production production NOUN ct-10491 108 17 in in ADP ct-10491 108 18 the the DET ct-10491 108 19 dog dog NOUN ct-10491 108 20 during during ADP ct-10491 108 21 our our PRON ct-10491 108 22 study study NOUN ct-10491 108 23 . . PUNCT ct-10491 109 1 there there PRON ct-10491 109 2 were be VERB ct-10491 109 3 only only ADV ct-10491 109 4 4 4 NUM ct-10491 109 5 timepoints timepoint NOUN ct-10491 109 6 in in ADP ct-10491 109 7 pups pup NOUN ct-10491 109 8 from from ADP ct-10491 109 9 2 2 NUM ct-10491 109 10 litters litter NOUN ct-10491 109 11 with with ADP ct-10491 109 12 carprofen carprofen PROPN ct-10491 109 13 concentrations concentration NOUN ct-10491 109 14 above above ADP ct-10491 109 15 the the DET ct-10491 109 16 loq loq PROPN ct-10491 109 17 . . PUNCT ct-10491 110 1 this this PRON ct-10491 110 2 agreed agree VERB ct-10491 110 3 with with ADP ct-10491 110 4 our our PRON ct-10491 110 5 hypothesis hypothesis NOUN ct-10491 110 6 that that PRON ct-10491 110 7 carprofen carprofen NOUN ct-10491 110 8 distribution distribution NOUN ct-10491 110 9 to to ADP ct-10491 110 10 milk milk NOUN ct-10491 110 11 is be AUX ct-10491 110 12 low low ADJ ct-10491 110 13 and and CCONJ ct-10491 110 14 exposure exposure NOUN ct-10491 110 15 to to ADP ct-10491 110 16 nursing nursing NOUN ct-10491 110 17 pups pup NOUN ct-10491 110 18 is be AUX ct-10491 110 19 too too ADV ct-10491 110 20 low low ADJ ct-10491 110 21 to to PART ct-10491 110 22 produce produce VERB ct-10491 110 23 measurable measurable ADJ ct-10491 110 24 pup pup ADJ ct-10491 110 25 plasma plasma NOUN ct-10491 110 26 concentrations concentration NOUN ct-10491 110 27 . . PUNCT ct-10491 111 1 most most ADJ ct-10491 111 2 of of ADP ct-10491 111 3 the the DET ct-10491 111 4 samples sample NOUN ct-10491 111 5 with with ADP ct-10491 111 6 concentrations concentration NOUN ct-10491 111 7 above above ADP ct-10491 111 8 the the DET ct-10491 111 9 loq loq PROPN ct-10491 111 10 were be AUX ct-10491 111 11 from from ADP ct-10491 111 12 litter litter NOUN ct-10491 111 13 1 1 NUM ct-10491 111 14 . . PUNCT ct-10491 111 15 overall overall ADJ ct-10491 111 16 , , PUNCT ct-10491 111 17 pup pup ADJ ct-10491 111 18 plasma plasma NOUN ct-10491 111 19 concentrations concentration NOUN ct-10491 111 20 were be AUX ct-10491 111 21 less less ADJ ct-10491 111 22 than than ADP ct-10491 111 23 10 10 NUM ct-10491 111 24 % % NOUN ct-10491 111 25 of of ADP ct-10491 111 26 maternal maternal ADJ ct-10491 111 27 concentrations concentration NOUN ct-10491 111 28 , , PUNCT ct-10491 111 29 consistent consistent ADJ ct-10491 111 30 with with ADP ct-10491 111 31 our our PRON ct-10491 111 32 hypothesis hypothesis NOUN ct-10491 111 33 and and CCONJ ct-10491 111 34 observation observation NOUN ct-10491 111 35 from from ADP ct-10491 111 36 human human ADJ ct-10491 111 37 infant infant PROPN ct-10491 111 38 exposure.19 exposure.19 PROPN ct-10491 111 39 - - PUNCT ct-10491 111 40 22 22 NUM ct-10491 111 41 despite despite SCONJ ct-10491 111 42 our our PRON ct-10491 111 43 small small ADJ ct-10491 111 44 sample sample NOUN ct-10491 111 45 size size NOUN ct-10491 111 46 , , PUNCT ct-10491 111 47 the the DET ct-10491 111 48 low low ADJ ct-10491 111 49 and and CCONJ ct-10491 111 50 unquantifiable unquantifiable ADJ ct-10491 111 51 concentrations concentration NOUN ct-10491 111 52 of of ADP ct-10491 111 53 carprofen carprofen NOUN ct-10491 111 54 in in ADP ct-10491 111 55 milk milk NOUN ct-10491 111 56 were be AUX ct-10491 111 57 similar similar ADJ ct-10491 111 58 to to ADP ct-10491 111 59 the the DET ct-10491 111 60 low low ADJ ct-10491 111 61 concentrations concentration NOUN ct-10491 111 62 reported18 reported18 NOUN ct-10491 111 63 after after ADP ct-10491 111 64 a a DET ct-10491 111 65 5 5 NUM ct-10491 111 66 - - PUNCT ct-10491 111 67 day day NOUN ct-10491 111 68 oral oral ADJ ct-10491 111 69 treatment treatment NOUN ct-10491 111 70 of of ADP ct-10491 111 71 carprofen carprofen NOUN ct-10491 111 72 ; ; PUNCT ct-10491 111 73 that that DET ct-10491 111 74 study study NOUN ct-10491 111 75 had have VERB ct-10491 111 76 slightly slightly ADV ct-10491 111 77 higher high ADJ ct-10491 111 78 concentrations concentration NOUN ct-10491 111 79 of of ADP ct-10491 111 80 carprofen carprofen NOUN ct-10491 111 81 in in ADP ct-10491 111 82 the the DET ct-10491 111 83 milk milk NOUN ct-10491 111 84 compared compare VERB ct-10491 111 85 to to ADP ct-10491 111 86 our our PRON ct-10491 111 87 study study NOUN ct-10491 111 88 that that PRON ct-10491 111 89 may may AUX ct-10491 111 90 be be AUX ct-10491 111 91 attributed attribute VERB ct-10491 111 92 to to ADP ct-10491 111 93 the the DET ct-10491 111 94 difference difference NOUN ct-10491 111 95 in in ADP ct-10491 111 96 the the DET ct-10491 111 97 stage stage NOUN ct-10491 111 98 of of ADP ct-10491 111 99 lactation lactation NOUN ct-10491 111 100 during during ADP ct-10491 111 101 the the DET ct-10491 111 102 sampling sampling NOUN ct-10491 111 103 period period NOUN ct-10491 111 104 . . PUNCT ct-10491 112 1 at at ADP ct-10491 112 2 the the DET ct-10491 112 3 beginning beginning NOUN ct-10491 112 4 of of ADP ct-10491 112 5 lactation lactation NOUN ct-10491 112 6 , , PUNCT ct-10491 112 7 the the DET ct-10491 112 8 volume volume NOUN ct-10491 112 9 of of ADP ct-10491 112 10 milk milk NOUN ct-10491 112 11 produced produce VERB ct-10491 112 12 is be AUX ct-10491 112 13 smaller small ADJ ct-10491 112 14 and and CCONJ ct-10491 112 15 colostrum colostrum NOUN ct-10491 112 16 is be AUX ct-10491 112 17 excreted excrete VERB ct-10491 112 18 . . PUNCT ct-10491 113 1 therefore therefore ADV ct-10491 113 2 , , PUNCT ct-10491 113 3 larger large ADJ ct-10491 113 4 - - PUNCT ct-10491 113 5 sized sized ADJ ct-10491 113 6 proteins protein NOUN ct-10491 113 7 will will AUX ct-10491 113 8 pass pass VERB ct-10491 113 9 more more ADV ct-10491 113 10 readily readily ADV ct-10491 113 11 through through ADP ct-10491 113 12 the the DET ct-10491 113 13 mammary mammary ADJ ct-10491 113 14 gland gland NOUN ct-10491 113 15 barrier barrier NOUN ct-10491 113 16 in in ADP ct-10491 113 17 the the DET ct-10491 113 18 first first ADJ ct-10491 113 19 24 24 NUM ct-10491 113 20 - - PUNCT ct-10491 113 21 hours hour NOUN ct-10491 113 22 as as ADV ct-10491 113 23 well well ADV ct-10491 113 24 as as ADP ct-10491 113 25 a a DET ct-10491 113 26 higher high ADJ ct-10491 113 27 concentration concentration NOUN ct-10491 113 28 due due ADP ct-10491 113 29 to to ADP ct-10491 113 30 the the DET ct-10491 113 31 smaller small ADJ ct-10491 113 32 volume volume NOUN ct-10491 113 33 of of ADP ct-10491 113 34 milk milk NOUN ct-10491 113 35 produced produce VERB ct-10491 113 36 at at ADP ct-10491 113 37 this this DET ct-10491 113 38 time time NOUN ct-10491 113 39 . . PUNCT ct-10491 114 1 in in ADP ct-10491 114 2 our our PRON ct-10491 114 3 study study NOUN ct-10491 114 4 , , PUNCT ct-10491 114 5 dogs dog NOUN ct-10491 114 6 were be AUX ct-10491 114 7 at at ADP ct-10491 114 8 2 2 NUM ct-10491 114 9 - - SYM ct-10491 114 10 4 4 NUM ct-10491 114 11 weeks week NOUN ct-10491 114 12 of of ADP ct-10491 114 13 lactation lactation NOUN ct-10491 114 14 in in ADP ct-10491 114 15 which which PRON ct-10491 114 16 the the DET ct-10491 114 17 mammary mammary ADJ ct-10491 114 18 epithelial epithelial ADJ ct-10491 114 19 tight tight ADJ ct-10491 114 20 junctions junction NOUN ct-10491 114 21 are be AUX ct-10491 114 22 more more ADV ct-10491 114 23 restrictive restrictive ADJ ct-10491 114 24 and and CCONJ ct-10491 114 25 higher high ADJ ct-10491 114 26 milk milk NOUN ct-10491 114 27 volume volume NOUN ct-10491 114 28 produces produce VERB ct-10491 114 29 a a DET ct-10491 114 30 dilution dilution NOUN ct-10491 114 31 factor factor NOUN ct-10491 114 32 . . PUNCT ct-10491 115 1 other other ADJ ct-10491 115 2 differences difference NOUN ct-10491 115 3 are be AUX ct-10491 115 4 the the DET ct-10491 115 5 sampling sampling NOUN ct-10491 115 6 and and CCONJ ct-10491 115 7 analyzing analyzing NOUN ct-10491 115 8 technique technique NOUN ct-10491 115 9 . . PUNCT ct-10491 116 1 we we PRON ct-10491 116 2 chose choose VERB ct-10491 116 3 an an DET ct-10491 116 4 intensive intensive ADJ ct-10491 116 5 sampling sampling NOUN ct-10491 116 6 model model NOUN ct-10491 116 7 after after ADP ct-10491 116 8 a a DET ct-10491 116 9 single single ADJ ct-10491 116 10 dose dose NOUN ct-10491 116 11 of of ADP ct-10491 116 12 carprofen carprofen PROPN ct-10491 116 13 for for ADP ct-10491 116 14 both both DET ct-10491 116 15 maternal maternal ADJ ct-10491 116 16 plasma plasma NOUN ct-10491 116 17 and and CCONJ ct-10491 116 18 milk milk NOUN ct-10491 116 19 along along ADP ct-10491 116 20 with with ADP ct-10491 116 21 plasma plasma NOUN ct-10491 116 22 from from ADP ct-10491 116 23 nursing nursing NOUN ct-10491 116 24 puppies puppy NOUN ct-10491 116 25 , , PUNCT ct-10491 116 26 whereas whereas SCONJ ct-10491 116 27 once once ADV ct-10491 116 28 daily daily ADJ ct-10491 116 29 sampling sampling NOUN ct-10491 116 30 of of ADP ct-10491 116 31 maternal maternal ADJ ct-10491 116 32 milk milk NOUN ct-10491 116 33 over over ADP ct-10491 116 34 a a DET ct-10491 116 35 5 5 NUM ct-10491 116 36 - - PUNCT ct-10491 116 37 day day NOUN ct-10491 116 38 course course NOUN ct-10491 116 39 of of ADP ct-10491 116 40 oral oral ADJ ct-10491 116 41 carprofen carprofen NOUN ct-10491 116 42 ( ( PUNCT ct-10491 116 43 2 2 NUM ct-10491 116 44 mg mg PROPN ct-10491 116 45 / / SYM ct-10491 116 46 kg kg PROPN ct-10491 116 47 twice twice ADV ct-10491 116 48 per per ADP ct-10491 116 49 day day NOUN ct-10491 116 50 ) ) PUNCT ct-10491 116 51 was be AUX ct-10491 116 52 chosen.18 chosen.18 VERB ct-10491 116 53 by by ADP ct-10491 116 54 only only ADV ct-10491 116 55 collecting collect VERB ct-10491 116 56 milk milk NOUN ct-10491 116 57 samples sample NOUN ct-10491 116 58 once once ADV ct-10491 116 59 a a DET ct-10491 116 60 day day NOUN ct-10491 116 61 , , PUNCT ct-10491 116 62 changes change NOUN ct-10491 116 63 in in ADP ct-10491 116 64 milk milk NOUN ct-10491 116 65 concentrations concentration NOUN ct-10491 116 66 ( ( PUNCT ct-10491 116 67 foremilk foremilk NOUN ct-10491 116 68 versus versus ADP ct-10491 116 69 hindmilk hindmilk NOUN ct-10491 116 70 and and CCONJ ct-10491 116 71 interglandular interglandular ADJ ct-10491 116 72 variations variation NOUN ct-10491 116 73 ) ) PUNCT ct-10491 116 74 may may AUX ct-10491 116 75 be be AUX ct-10491 116 76 missed miss VERB ct-10491 116 77 that that PRON ct-10491 116 78 has have AUX ct-10491 116 79 been be AUX ct-10491 116 80 described describe VERB ct-10491 116 81 in in ADP ct-10491 116 82 human human ADJ ct-10491 116 83 lactation lactation NOUN ct-10491 116 84 studies.38 studies.38 NOUN ct-10491 116 85 milk milk NOUN ct-10491 116 86 samples sample NOUN ct-10491 116 87 were be AUX ct-10491 116 88 analyzed analyze VERB ct-10491 116 89 by by ADP ct-10491 116 90 liquid liquid ADJ ct-10491 116 91 chromatography18 chromatography18 NOUN ct-10491 116 92 as as ADP ct-10491 116 93 in in ADP ct-10491 116 94 the the DET ct-10491 116 95 current current ADJ ct-10491 116 96 study study NOUN ct-10491 116 97 . . PUNCT ct-10491 117 1 the the DET ct-10491 117 2 main main ADJ ct-10491 117 3 difference difference NOUN ct-10491 117 4 in in ADP ct-10491 117 5 analyzing analyze VERB ct-10491 117 6 techniques technique NOUN ct-10491 117 7 involved involve VERB ct-10491 117 8 the the DET ct-10491 117 9 maternal maternal ADJ ct-10491 117 10 and and CCONJ ct-10491 117 11 neonatal neonatal ADJ ct-10491 117 12 plasma plasma NOUN ct-10491 117 13 that that PRON ct-10491 117 14 were be AUX ct-10491 117 15 calculated calculate VERB ct-10491 117 16 via via ADP ct-10491 117 17 concentration concentration NOUN ct-10491 117 18 - - PUNCT ct-10491 117 19 time time NOUN ct-10491 117 20 course course NOUN ct-10491 117 21 simulation simulation NOUN ct-10491 117 22 models.18 models.18 PROPN ct-10491 117 23 versus versus ADP ct-10491 117 24 in in ADP ct-10491 117 25 real real ADJ ct-10491 117 26 time time NOUN ct-10491 117 27 in in ADP ct-10491 117 28 the the DET ct-10491 117 29 current current ADJ ct-10491 117 30 study study NOUN ct-10491 117 31 . . PUNCT ct-10491 118 1 limitations limitation NOUN ct-10491 118 2 a a DET ct-10491 118 3 major major ADJ ct-10491 118 4 limitation limitation NOUN ct-10491 118 5 of of ADP ct-10491 118 6 our our PRON ct-10491 118 7 study study NOUN ct-10491 118 8 was be AUX ct-10491 118 9 the the DET ct-10491 118 10 small small ADJ ct-10491 118 11 sample sample NOUN ct-10491 118 12 size size NOUN ct-10491 118 13 that that PRON ct-10491 118 14 resulted result VERB ct-10491 118 15 in in ADP ct-10491 118 16 high high ADJ ct-10491 118 17 inter inter ADJ ct-10491 118 18 - - ADJ ct-10491 118 19 individual individual ADJ ct-10491 118 20 variation variation NOUN ct-10491 118 21 among among ADP ct-10491 118 22 dogs dog NOUN ct-10491 118 23 . . PUNCT ct-10491 119 1 clearly clearly ADV ct-10491 119 2 , , PUNCT ct-10491 119 3 a a DET ct-10491 119 4 larger large ADJ ct-10491 119 5 study study NOUN ct-10491 119 6 with with ADP ct-10491 119 7 more more ADJ ct-10491 119 8 dogs dog NOUN ct-10491 119 9 is be AUX ct-10491 119 10 needed need VERB ct-10491 119 11 to to PART ct-10491 119 12 confirm confirm VERB ct-10491 119 13 our our PRON ct-10491 119 14 results result NOUN ct-10491 119 15 . . PUNCT ct-10491 120 1 aside aside ADV ct-10491 120 2 from from ADP ct-10491 120 3 the the DET ct-10491 120 4 small small ADJ ct-10491 120 5 sample sample NOUN ct-10491 120 6 size size NOUN ct-10491 120 7 , , PUNCT ct-10491 120 8 another another DET ct-10491 120 9 limitation limitation NOUN ct-10491 120 10 was be AUX ct-10491 120 11 the the DET ct-10491 120 12 single single ADJ ct-10491 120 13 carprofen carprofen NOUN ct-10491 120 14 treatment treatment NOUN ct-10491 120 15 before before ADP ct-10491 120 16 steady steady ADJ ct-10491 120 17 - - PUNCT ct-10491 120 18 state state NOUN ct-10491 120 19 conditions condition NOUN ct-10491 120 20 were be AUX ct-10491 120 21 met meet VERB ct-10491 120 22 . . PUNCT ct-10491 121 1 because because SCONJ ct-10491 121 2 we we PRON ct-10491 121 3 used use VERB ct-10491 121 4 dogs dog NOUN ct-10491 121 5 recruited recruit VERB ct-10491 121 6 from from ADP ct-10491 121 7 client client NOUN ct-10491 121 8 - - PUNCT ct-10491 121 9 owned own VERB ct-10491 121 10 kennels kennel NOUN ct-10491 121 11 there there PRON ct-10491 121 12 were be VERB ct-10491 121 13 limitations limitation NOUN ct-10491 121 14 for for ADP ct-10491 121 15 the the DET ct-10491 121 16 number number NOUN ct-10491 121 17 of of ADP ct-10491 121 18 doses dose NOUN ct-10491 121 19 and and CCONJ ct-10491 121 20 samples sample NOUN ct-10491 121 21 from from ADP ct-10491 121 22 dogs dog NOUN ct-10491 121 23 and and CCONJ ct-10491 121 24 pups pup NOUN ct-10491 121 25 . . PUNCT ct-10491 122 1 we we PRON ct-10491 122 2 were be AUX ct-10491 122 3 restricted restrict VERB ct-10491 122 4 in in ADP ct-10491 122 5 the the DET ct-10491 122 6 volume volume NOUN ct-10491 122 7 of of ADP ct-10491 122 8 whole whole ADJ ct-10491 122 9 blood blood NOUN ct-10491 122 10 that that PRON ct-10491 122 11 could could AUX ct-10491 122 12 be be AUX ct-10491 122 13 collected collect VERB ct-10491 122 14 for for ADP ct-10491 122 15 an an DET ct-10491 122 16 individual individual ADJ ct-10491 122 17 pup pup NOUN ct-10491 122 18 during during ADP ct-10491 122 19 the the DET ct-10491 122 20 sampling sample VERB ct-10491 122 21 period period NOUN ct-10491 122 22 for for ADP ct-10491 122 23 that that DET ct-10491 122 24 litter litter NOUN ct-10491 122 25 . . PUNCT ct-10491 123 1 although although SCONJ ct-10491 123 2 we we PRON ct-10491 123 3 used use VERB ct-10491 123 4 an an DET ct-10491 123 5 intravenous intravenous ADJ ct-10491 123 6 treatment treatment NOUN ct-10491 123 7 that that PRON ct-10491 123 8 is be AUX ct-10491 123 9 not not PART ct-10491 123 10 included include VERB ct-10491 123 11 in in ADP ct-10491 123 12 approved approve VERB ct-10491 123 13 us we PRON ct-10491 123 14 label label NOUN ct-10491 123 15 , , PUNCT ct-10491 123 16 this this PRON ct-10491 123 17 was be AUX ct-10491 123 18 the the DET ct-10491 123 19 preferred preferred ADJ ct-10491 123 20 route route NOUN ct-10491 123 21 for for ADP ct-10491 123 22 calculating calculate VERB ct-10491 123 23 pharmacokinetic pharmacokinetic ADJ ct-10491 123 24 parameters parameter NOUN ct-10491 123 25 such such ADJ ct-10491 123 26 as as ADP ct-10491 123 27 clearance clearance NOUN ct-10491 123 28 and and CCONJ ct-10491 123 29 volume volume NOUN ct-10491 123 30 of of ADP ct-10491 123 31 distribution distribution NOUN ct-10491 123 32 . . PUNCT ct-10491 124 1 furthermore furthermore ADV ct-10491 124 2 , , PUNCT ct-10491 124 3 intravenous intravenous ADJ ct-10491 124 4 route route NOUN ct-10491 124 5 studies study NOUN ct-10491 124 6 in in ADP ct-10491 124 7 dogs dog NOUN ct-10491 124 8 had have VERB ct-10491 124 9 no no DET ct-10491 124 10 adverse adverse ADJ ct-10491 124 11 effects effect NOUN ct-10491 124 12 in in ADP ct-10491 124 13 dogs.1,13 dogs.1,13 NOUN ct-10491 124 14 however however ADV ct-10491 124 15 , , PUNCT ct-10491 124 16 there there PRON ct-10491 124 17 was be VERB ct-10491 124 18 not not PART ct-10491 124 19 enough enough ADJ ct-10491 124 20 data datum NOUN ct-10491 124 21 from from ADP ct-10491 124 22 the the DET ct-10491 124 23 milk milk NOUN ct-10491 124 24 and and CCONJ ct-10491 124 25 pups pup NOUN ct-10491 124 26 to to PART ct-10491 124 27 calculate calculate VERB ct-10491 124 28 pharmacokinetic pharmacokinetic ADJ ct-10491 124 29 parameters parameter NOUN ct-10491 124 30 from from ADP ct-10491 124 31 these these DET ct-10491 124 32 samples sample NOUN ct-10491 124 33 . . PUNCT ct-10491 125 1 despite despite SCONJ ct-10491 125 2 these these DET ct-10491 125 3 limitations limitation NOUN ct-10491 125 4 , , PUNCT ct-10491 125 5 this this PRON ct-10491 125 6 is be AUX ct-10491 125 7 the the DET ct-10491 125 8 first first ADJ ct-10491 125 9 study study NOUN ct-10491 125 10 to to ADP ct-10491 125 11 our our PRON ct-10491 125 12 knowledge knowledge NOUN ct-10491 125 13 that that PRON ct-10491 125 14 has have AUX ct-10491 125 15 measured measure VERB ct-10491 125 16 carprofen carprofen NOUN ct-10491 125 17 in in ADP ct-10491 125 18 neonatal neonatal ADJ ct-10491 125 19 plasma plasma NOUN ct-10491 125 20 and and CCONJ ct-10491 125 21 canine canine VERB ct-10491 125 22 milk milk NOUN ct-10491 125 23 at at ADP ct-10491 125 24 multiple multiple ADJ ct-10491 125 25 timepoints timepoint NOUN ct-10491 125 26 after after ADP ct-10491 125 27 maternal maternal ADJ ct-10491 125 28 treatment treatment NOUN ct-10491 125 29 , , PUNCT ct-10491 125 30 an an DET ct-10491 125 31 advance advance NOUN ct-10491 125 32 over over ADP ct-10491 125 33 studies study NOUN ct-10491 125 34 in in ADP ct-10491 125 35 dogs dog NOUN ct-10491 125 36 . . PUNCT ct-10491 126 1 in in ADP ct-10491 126 2 conclusion conclusion NOUN ct-10491 126 3 , , PUNCT ct-10491 126 4 carprofen carprofen NOUN ct-10491 126 5 treatment treatment NOUN ct-10491 126 6 to to ADP ct-10491 126 7 lactating lactate VERB ct-10491 126 8 dogs dog NOUN ct-10491 126 9 has have VERB ct-10491 126 10 low low ADJ ct-10491 126 11 transference transference NOUN ct-10491 126 12 to to ADP ct-10491 126 13 milk milk NOUN ct-10491 126 14 and and CCONJ ct-10491 126 15 a a DET ct-10491 126 16 low low ADJ ct-10491 126 17 risk risk NOUN ct-10491 126 18 of of ADP ct-10491 126 19 neonatal neonatal ADJ ct-10491 126 20 exposure exposure NOUN ct-10491 126 21 in in ADP ct-10491 126 22 midlactation midlactation NOUN ct-10491 126 23 with with ADP ct-10491 126 24 an an DET ct-10491 126 25 intact intact ADJ ct-10491 126 26 mammary mammary ADJ ct-10491 126 27 epithelium epithelium NOUN ct-10491 126 28 barrier barrier NOUN ct-10491 126 29 . . PUNCT ct-10491 127 1 http://dx.doi.org/10.58292/ct.v16.10491 http://dx.doi.org/10.58292/ct.v16.10491 NOUN ct-10491 127 2 6 6 NUM ct-10491 127 3 citation citation NOUN ct-10491 127 4 : : PUNCT ct-10491 127 5 clinical clinical ADJ ct-10491 127 6 theriogenology theriogenology NOUN ct-10491 127 7 2024 2024 NUM ct-10491 127 8 , , PUNCT ct-10491 127 9 16 16 NUM ct-10491 127 10 , , PUNCT ct-10491 127 11 10491 10491 NUM ct-10491 127 12 , , PUNCT ct-10491 127 13 http://dx.doi.org/10.58292/ct.v16.10491 http://dx.doi.org/10.58292/ct.v16.10491 NOUN ct-10491 127 14 carprofen carprofen NOUN ct-10491 127 15 disposition disposition NOUN ct-10491 127 16 observed observe VERB ct-10491 127 17 in in ADP ct-10491 127 18 lactating lactate VERB ct-10491 127 19 dogs dog NOUN ct-10491 127 20 in in ADP ct-10491 127 21 our our PRON ct-10491 127 22 study study NOUN ct-10491 127 23 had have VERB ct-10491 127 24 a a DET ct-10491 127 25 higher high ADJ ct-10491 127 26 clearance clearance NOUN ct-10491 127 27 rate rate NOUN ct-10491 127 28 and and CCONJ ct-10491 127 29 volume volume NOUN ct-10491 127 30 of of ADP ct-10491 127 31 distribution distribution NOUN ct-10491 127 32 that that PRON ct-10491 127 33 may may AUX ct-10491 127 34 be be AUX ct-10491 127 35 attributed attribute VERB ct-10491 127 36 to to ADP ct-10491 127 37 the the DET ct-10491 127 38 unique unique ADJ ct-10491 127 39 physiology physiology NOUN ct-10491 127 40 in in ADP ct-10491 127 41 this this DET ct-10491 127 42 group group NOUN ct-10491 127 43 compared compare VERB ct-10491 127 44 to to ADP ct-10491 127 45 nonlactating nonlactate VERB ct-10491 127 46 dogs dog NOUN ct-10491 127 47 . . PUNCT ct-10491 128 1 our our PRON ct-10491 128 2 study study NOUN ct-10491 128 3 supported support VERB ct-10491 128 4 our our PRON ct-10491 128 5 hypothesis hypothesis NOUN ct-10491 128 6 that that PRON ct-10491 128 7 carprofen carprofen PROPN ct-10491 128 8 is be AUX ct-10491 128 9 safe safe ADJ ct-10491 128 10 for for ADP ct-10491 128 11 lactating lactate VERB ct-10491 128 12 dogs dog NOUN ct-10491 128 13 as as SCONJ ct-10491 128 14 there there PRON ct-10491 128 15 is be VERB ct-10491 128 16 low low ADJ ct-10491 128 17 transfer transfer NOUN ct-10491 128 18 into into ADP ct-10491 128 19 their their PRON ct-10491 128 20 milk milk NOUN ct-10491 128 21 and and CCONJ ct-10491 128 22 to to ADP ct-10491 128 23 their their PRON ct-10491 128 24 pups pup NOUN ct-10491 128 25 , , PUNCT ct-10491 128 26 which which PRON ct-10491 128 27 is be AUX ct-10491 128 28 similar similar ADJ ct-10491 128 29 to to PART ct-10491 128 30 reports.16,18 reports.16,18 VERB ct-10491 128 31 funding fund VERB ct-10491 128 32 north north PROPN ct-10491 128 33 carolina carolina PROPN ct-10491 128 34 state state PROPN ct-10491 128 35 university university PROPN ct-10491 128 36 college college NOUN ct-10491 128 37 of of ADP ct-10491 128 38 veterinary veterinary ADJ ct-10491 128 39 medicine medicine NOUN ct-10491 128 40 intramural intramural ADJ ct-10491 128 41 grants grant NOUN ct-10491 128 42 . . PUNCT ct-10491 129 1 conflicts conflict NOUN ct-10491 129 2 of of ADP ct-10491 129 3 interest interest NOUN ct-10491 129 4 amber amber PROPN ct-10491 129 5 nebel nebel PROPN ct-10491 129 6 - - PUNCT ct-10491 129 7 karp karp PROPN ct-10491 129 8 : : PUNCT ct-10491 129 9 no no DET ct-10491 129 10 conflicts conflict NOUN ct-10491 129 11 of of ADP ct-10491 129 12 interest interest NOUN ct-10491 129 13 to to PART ct-10491 129 14 disclose disclose VERB ct-10491 129 15 . . PUNCT ct-10491 130 1 mark mark PROPN ct-10491 130 2 papich papich PROPN ct-10491 130 3 has have AUX ct-10491 130 4 received receive VERB ct-10491 130 5 gifts gift NOUN ct-10491 130 6 , , PUNCT ct-10491 130 7 honoraria honorarium NOUN ct-10491 130 8 , , PUNCT ct-10491 130 9 consulting consulting NOUN ct-10491 130 10 fees fee NOUN ct-10491 130 11 , , PUNCT ct-10491 130 12 and and CCONJ ct-10491 130 13 research research NOUN ct-10491 130 14 support support NOUN ct-10491 130 15 from from ADP ct-10491 130 16 zoetis zoetis PROPN ct-10491 130 17 , , PUNCT ct-10491 130 18 the the DET ct-10491 130 19 sponsor sponsor NOUN ct-10491 130 20 of of ADP ct-10491 130 21 carprofen carprofen PROPN ct-10491 130 22 , , PUNCT ct-10491 130 23 but but CCONJ ct-10491 130 24 did do AUX ct-10491 130 25 not not PART ct-10491 130 26 receive receive VERB ct-10491 130 27 any any DET ct-10491 130 28 payment payment NOUN ct-10491 130 29 or or CCONJ ct-10491 130 30 research research NOUN ct-10491 130 31 support support NOUN ct-10491 130 32 for for ADP ct-10491 130 33 the the DET ct-10491 130 34 work work NOUN ct-10491 130 35 on on ADP ct-10491 130 36 this this DET ct-10491 130 37 study study NOUN ct-10491 130 38 . . PUNCT ct-10491 131 1 kristen kristen PROPN ct-10491 131 2 messenger messenger PROPN ct-10491 131 3 has have AUX ct-10491 131 4 received receive VERB ct-10491 131 5 gifts gift NOUN ct-10491 131 6 , , PUNCT ct-10491 131 7 honoraria honorarium NOUN ct-10491 131 8 , , PUNCT ct-10491 131 9 and and CCONJ ct-10491 131 10 research research NOUN ct-10491 131 11 support support NOUN ct-10491 131 12 from from ADP ct-10491 131 13 zoetis zoetis PROPN ct-10491 131 14 , , PUNCT ct-10491 131 15 but but CCONJ ct-10491 131 16 did do AUX ct-10491 131 17 not not PART ct-10491 131 18 receive receive VERB ct-10491 131 19 any any DET ct-10491 131 20 payment payment NOUN ct-10491 131 21 or or CCONJ ct-10491 131 22 research research NOUN ct-10491 131 23 support support NOUN ct-10491 131 24 for for ADP ct-10491 131 25 the the DET ct-10491 131 26 work work NOUN ct-10491 131 27 on on ADP ct-10491 131 28 this this DET ct-10491 131 29 study study NOUN ct-10491 131 30 . . PUNCT ct-10491 132 1 sara sara PROPN ct-10491 132 2 lyle lyle PROPN ct-10491 132 3 : : PUNCT ct-10491 132 4 no no DET ct-10491 132 5 conflicts conflict NOUN ct-10491 132 6 of of ADP ct-10491 132 7 interest interest NOUN ct-10491 132 8 to to PART ct-10491 132 9 disclose disclose VERB ct-10491 132 10 . . PUNCT ct-10491 133 1 references reference NOUN ct-10491 133 2 1 1 NUM ct-10491 133 3 . . PUNCT ct-10491 134 1 schmitt schmitt PROPN ct-10491 134 2 m m PROPN ct-10491 134 3 , , PUNCT ct-10491 134 4 guentert guentert VERB ct-10491 134 5 tw tw NOUN ct-10491 134 6 : : PUNCT ct-10491 134 7 biopharmaceutical biopharmaceutical ADJ ct-10491 134 8 evaluation evaluation NOUN ct-10491 134 9 of of ADP ct-10491 134 10 carprofen carprofen NOUN ct-10491 134 11 following follow VERB ct-10491 134 12 single single ADJ ct-10491 134 13 intravenous intravenous ADJ ct-10491 134 14 , , PUNCT ct-10491 134 15 oral oral ADJ ct-10491 134 16 , , PUNCT ct-10491 134 17 and and CCONJ ct-10491 134 18 rectal rectal ADJ ct-10491 134 19 doses dose NOUN ct-10491 134 20 in in ADP ct-10491 134 21 dogs dog NOUN ct-10491 134 22 . . PUNCT ct-10491 135 1 biopharm biopharm NOUN ct-10491 135 2 drug drug NOUN ct-10491 135 3 dispos dispos PROPN ct-10491 135 4 1990;11:585 1990;11:585 NUM ct-10491 135 5 - - SYM ct-10491 135 6 594 594 NUM ct-10491 135 7 . . PUNCT ct-10491 136 1 doi doi NOUN ct-10491 136 2 : : PUNCT ct-10491 136 3 10.1002/ 10.1002/ NUM ct-10491 136 4 bdd.2510110704 bdd.2510110704 SYM ct-10491 136 5 2 2 NUM ct-10491 136 6 . . PUNCT ct-10491 137 1 the the DET ct-10491 137 2 united united PROPN ct-10491 137 3 states states PROPN ct-10491 137 4 pharmacopeial pharmacopeial ADJ ct-10491 137 5 convention convention NOUN ct-10491 137 6 . . PUNCT ct-10491 138 1 ( ( PUNCT ct-10491 138 2 2007 2007 NUM ct-10491 138 3 , , PUNCT ct-10491 138 4 january january PROPN ct-10491 138 5 1 1 NUM ct-10491 138 6 ) ) PUNCT ct-10491 138 7 . . PUNCT ct-10491 139 1 carprofen carprofen NOUN ct-10491 139 2 ( ( PUNCT ct-10491 139 3 veterinary veterinary ADJ ct-10491 139 4 - - PUNCT ct-10491 139 5 systemic systemic ADJ ct-10491 139 6 ) ) PUNCT ct-10491 139 7 . . PUNCT ct-10491 140 1 available available ADJ ct-10491 140 2 from from ADP ct-10491 140 3 : : PUNCT ct-10491 140 4 https://cdn https://cdn PROPN ct-10491 140 5 . . PUNCT ct-10491 141 1 ymaws.com/www.aavpt.org/resource/resmgr/imported/carprofen.pdf ymaws.com/www.aavpt.org/resource/resmgr/imported/carprofen.pdf NOUN ct-10491 142 1 [ [ X ct-10491 142 2 cited cite VERB ct-10491 142 3 19 19 NUM ct-10491 142 4 january january PROPN ct-10491 142 5 2023 2023 NUM ct-10491 142 6 ] ] PUNCT ct-10491 142 7 . . PUNCT ct-10491 143 1 3 3 X ct-10491 143 2 . . X ct-10491 143 3 kukanich kukanich PROPN ct-10491 143 4 b b PROPN ct-10491 143 5 , , PUNCT ct-10491 143 6 bidgood bidgood NOUN ct-10491 143 7 t t PROPN ct-10491 143 8 , , PUNCT ct-10491 143 9 knesl knesl PROPN ct-10491 144 1 o o NOUN ct-10491 144 2 : : PUNCT ct-10491 144 3 clinical clinical ADJ ct-10491 144 4 pharmacology pharmacology NOUN ct-10491 144 5 of of ADP ct-10491 144 6 non non ADJ ct-10491 144 7 - - ADJ ct-10491 144 8 steroidal steroidal ADJ ct-10491 144 9 anti anti ADJ ct-10491 144 10 - - ADJ ct-10491 144 11 inflammatory inflammatory ADJ ct-10491 144 12 drugs drug NOUN ct-10491 144 13 in in ADP ct-10491 144 14 dogs dog NOUN ct-10491 144 15 . . PUNCT ct-10491 145 1 vet vet NOUN ct-10491 145 2 anesth anesth VERB ct-10491 145 3 analg analg PROPN ct-10491 145 4 2012;39:69 2012;39:69 PROPN ct-10491 145 5 - - SYM ct-10491 145 6 90 90 NUM ct-10491 145 7 . . PUNCT ct-10491 146 1 doi doi NOUN ct-10491 146 2 : : PUNCT ct-10491 146 3 10.1111 10.1111 NUM ct-10491 146 4 / / SYM ct-10491 146 5 j.1467 j.1467 ADV ct-10491 146 6 - - PUNCT ct-10491 146 7 2995.2011.00675.x 2995.2011.00675.x NUM ct-10491 146 8 4 4 NUM ct-10491 146 9 . . PUNCT ct-10491 146 10 ricketts ricketts PROPN ct-10491 146 11 ap ap PROPN ct-10491 146 12 , , PUNCT ct-10491 146 13 lundy lundy PROPN ct-10491 146 14 km km PROPN ct-10491 146 15 , , PUNCT ct-10491 146 16 seibel seibel PROPN ct-10491 146 17 sb sb PROPN ct-10491 146 18 : : PUNCT ct-10491 146 19 evaluation evaluation NOUN ct-10491 146 20 of of ADP ct-10491 146 21 selective selective ADJ ct-10491 146 22 inhibition inhibition NOUN ct-10491 146 23 of of ADP ct-10491 146 24 canine canine NOUN ct-10491 146 25 cyclooxygenase cyclooxygenase NOUN ct-10491 146 26 1 1 NUM ct-10491 146 27 and and CCONJ ct-10491 146 28 2 2 NUM ct-10491 146 29 by by ADP ct-10491 146 30 carprofen carprofen NOUN ct-10491 146 31 and and CCONJ ct-10491 146 32 other other ADJ ct-10491 146 33 nonsteroidal nonsteroidal ADJ ct-10491 146 34 anti anti ADJ ct-10491 146 35 - - ADJ ct-10491 146 36 inflammatory inflammatory ADJ ct-10491 146 37 drugs drug NOUN ct-10491 146 38 . . PUNCT ct-10491 147 1 am be AUX ct-10491 147 2 j j PROPN ct-10491 147 3 vet vet NOUN ct-10491 147 4 res re NOUN ct-10491 147 5 1998;59 1998;59 NUM ct-10491 147 6 : : PUNCT ct-10491 147 7 1441 1441 NUM ct-10491 147 8 - - SYM ct-10491 147 9 1446 1446 NUM ct-10491 147 10 . . PUNCT ct-10491 148 1 doi doi NOUN ct-10491 148 2 : : PUNCT ct-10491 148 3 10.2460 10.2460 NUM ct-10491 148 4 / / SYM ct-10491 148 5 ajvr.1998.59.11.1441 ajvr.1998.59.11.1441 NUM ct-10491 148 6 5 5 NUM ct-10491 148 7 . . X ct-10491 148 8 wilson wilson PROPN ct-10491 148 9 je je PROPN ct-10491 148 10 , , PUNCT ct-10491 148 11 chandrasekharan chandrasekharan VERB ct-10491 148 12 nv nv PROPN ct-10491 148 13 , , PUNCT ct-10491 148 14 westover westover PROPN ct-10491 148 15 kd kd PROPN ct-10491 148 16 , , PUNCT ct-10491 148 17 et et PROPN ct-10491 148 18 al al PROPN ct-10491 148 19 : : PUNCT ct-10491 148 20 determination determination NOUN ct-10491 148 21 of of ADP ct-10491 148 22 expression expression NOUN ct-10491 148 23 of of ADP ct-10491 148 24 cyclooxygenase-1 cyclooxygenase-1 PROPN ct-10491 148 25 and and CCONJ ct-10491 149 1 -2 -2 NOUN ct-10491 149 2 isozymes isozyme NOUN ct-10491 149 3 in in ADP ct-10491 149 4 canine canine NOUN ct-10491 149 5 tissues tissue NOUN ct-10491 149 6 and and CCONJ ct-10491 149 7 their their PRON ct-10491 149 8 differential differential ADJ ct-10491 149 9 sensitivity sensitivity NOUN ct-10491 149 10 to to PART ct-10491 149 11 nonsteroidal nonsteroidal VERB ct-10491 149 12 anti anti ADJ ct-10491 149 13 - - ADJ ct-10491 149 14 inflammatory inflammatory ADJ ct-10491 149 15 drugs drug NOUN ct-10491 149 16 . . PUNCT ct-10491 150 1 am be AUX ct-10491 150 2 j j PROPN ct-10491 150 3 vet vet NOUN ct-10491 150 4 res re NOUN ct-10491 150 5 2004;65:820 2004;65:820 ADV ct-10491 150 6 - - PUNCT ct-10491 150 7 818 818 NUM ct-10491 150 8 . . PUNCT ct-10491 151 1 doi doi NOUN ct-10491 151 2 : : PUNCT ct-10491 151 3 10.2460 10.2460 NUM ct-10491 151 4 / / SYM ct-10491 151 5 ajvr.2004.65.810 ajvr.2004.65.810 NOUN ct-10491 151 6 6 6 NUM ct-10491 151 7 . . PUNCT ct-10491 152 1 raekallio raekallio VERB ct-10491 152 2 mr mr PROPN ct-10491 152 3 , , PUNCT ct-10491 152 4 hielm hielm NOUN ct-10491 152 5 - - PUNCT ct-10491 152 6 björkman björkman NOUN ct-10491 152 7 ak ak PROPN ct-10491 152 8 , , PUNCT ct-10491 152 9 kejonen kejonen PROPN ct-10491 152 10 j j PROPN ct-10491 152 11 , , PUNCT ct-10491 152 12 et et PROPN ct-10491 152 13 al al PROPN ct-10491 152 14 : : PUNCT ct-10491 152 15 evaluation evaluation NOUN ct-10491 152 16 of of ADP ct-10491 152 17 adverse adverse ADJ ct-10491 152 18 effects effect NOUN ct-10491 152 19 of of ADP ct-10491 152 20 long long ADJ ct-10491 152 21 - - PUNCT ct-10491 152 22 term term NOUN ct-10491 152 23 orally orally ADV ct-10491 152 24 administered administer VERB ct-10491 152 25 carprofen carprofen NOUN ct-10491 152 26 in in ADP ct-10491 152 27 dogs dog NOUN ct-10491 152 28 . . PUNCT ct-10491 153 1 j j PROPN ct-10491 153 2 am be AUX ct-10491 153 3 vet vet NOUN ct-10491 153 4 med med ADJ ct-10491 153 5 assoc assoc PROPN ct-10491 153 6 2006;228:876 2006;228:876 PROPN ct-10491 153 7 - - SYM ct-10491 153 8 880 880 NUM ct-10491 153 9 . . PUNCT ct-10491 154 1 doi doi NOUN ct-10491 154 2 : : PUNCT ct-10491 154 3 10.2460/ 10.2460/ NUM ct-10491 154 4 javma.228.6.876 javma.228.6.876 ADP ct-10491 154 5 7 7 X ct-10491 154 6 . . PUNCT ct-10491 154 7 lascelles lascelle NOUN ct-10491 154 8 bdx bdx VERB ct-10491 154 9 , , PUNCT ct-10491 154 10 blikslager blikslager NOUN ct-10491 154 11 at at ADP ct-10491 154 12 , , PUNCT ct-10491 154 13 fox fox PROPN ct-10491 154 14 sm sm PROPN ct-10491 154 15 , , PUNCT ct-10491 154 16 et et PROPN ct-10491 154 17 al al PROPN ct-10491 154 18 : : PUNCT ct-10491 154 19 gastrointestinal gastrointestinal ADJ ct-10491 154 20 tract tract NOUN ct-10491 154 21 perforation perforation NOUN ct-10491 154 22 in in ADP ct-10491 154 23 dogs dog NOUN ct-10491 154 24 treated treat VERB ct-10491 154 25 with with ADP ct-10491 154 26 a a DET ct-10491 154 27 selective selective ADJ ct-10491 154 28 cyclooxygenase-2 cyclooxygenase-2 NUM ct-10491 154 29 inhibitor inhibitor NOUN ct-10491 154 30 : : PUNCT ct-10491 154 31 29 29 NUM ct-10491 154 32 cases case NOUN ct-10491 154 33 ( ( PUNCT ct-10491 154 34 2002–2003 2002–2003 NUM ct-10491 154 35 ) ) PUNCT ct-10491 154 36 . . PUNCT ct-10491 155 1 j j PROPN ct-10491 155 2 am be AUX ct-10491 155 3 vet vet NOUN ct-10491 155 4 med med ADJ ct-10491 155 5 assoc assoc NOUN ct-10491 155 6 2005;7 2005;7 NUM ct-10491 155 7 : : PUNCT ct-10491 155 8 1112 1112 NUM ct-10491 155 9 - - SYM ct-10491 155 10 1117 1117 NUM ct-10491 155 11 . . PUNCT ct-10491 156 1 doi doi NOUN ct-10491 156 2 : : PUNCT ct-10491 156 3 10.2460 10.2460 NUM ct-10491 156 4 / / SYM ct-10491 156 5 javma.2005.227.1112 javma.2005.227.1112 NOUN ct-10491 156 6 8 8 NUM ct-10491 156 7 . . PUNCT ct-10491 157 1 mckellar mckellar PROPN ct-10491 157 2 qa qa PROPN ct-10491 157 3 , , PUNCT ct-10491 157 4 delatour delatour VERB ct-10491 157 5 p p X ct-10491 157 6 , , PUNCT ct-10491 157 7 lees lee NOUN ct-10491 157 8 p p NOUN ct-10491 157 9 : : PUNCT ct-10491 157 10 stereospecific stereospecific ADJ ct-10491 157 11 pharmacokinetics pharmacokinetic NOUN ct-10491 157 12 and and CCONJ ct-10491 157 13 pharmacodynamics pharmacodynamic NOUN ct-10491 157 14 of of ADP ct-10491 157 15 carprofen carprofen PROPN ct-10491 157 16 in in ADP ct-10491 157 17 the the DET ct-10491 157 18 dog dog NOUN ct-10491 157 19 . . PUNCT ct-10491 158 1 j j PROPN ct-10491 158 2 vet vet NOUN ct-10491 158 3 pharmacol pharmacol PROPN ct-10491 158 4 ther ther ADV ct-10491 158 5 1994;17:447 1994;17:447 PROPN ct-10491 158 6 - - SYM ct-10491 158 7 454 454 NUM ct-10491 158 8 . . PUNCT ct-10491 159 1 doi doi NOUN ct-10491 159 2 : : PUNCT ct-10491 159 3 10.1111 10.1111 NUM ct-10491 159 4 / / SYM ct-10491 159 5 j.1365 j.1365 NOUN ct-10491 159 6 - - PUNCT ct-10491 159 7 2885.1994.tb00276.x 2885.1994.tb00276.x NUM ct-10491 159 8 9 9 NUM ct-10491 159 9 . . PUNCT ct-10491 160 1 rimadyl rimadyl NOUN ct-10491 160 2 ® ® NOUN ct-10491 160 3 package package NOUN ct-10491 160 4 insert insert NOUN ct-10491 160 5 . . PUNCT ct-10491 161 1 rimadyl rimadyl NOUN ct-10491 161 2 ® ® PROPN ct-10491 161 3 ( ( PUNCT ct-10491 161 4 carprofen carprofen NOUN ct-10491 161 5 ) ) PUNCT ct-10491 161 6 sterile sterile ADJ ct-10491 161 7 injectable injectable ADJ ct-10491 161 8 solution solution NOUN ct-10491 161 9 50 50 NUM ct-10491 161 10 mg mg NUM ct-10491 161 11 / / SYM ct-10491 161 12 ml ml NOUN ct-10491 161 13 . . PUNCT ct-10491 161 14 new new PROPN ct-10491 161 15 york york PROPN ct-10491 161 16 , , PUNCT ct-10491 161 17 ny ny PROPN ct-10491 161 18 ; ; PUNCT ct-10491 161 19 zoetis zoetis PROPN ct-10491 161 20 inc inc PROPN ct-10491 161 21 . . PROPN ct-10491 161 22 : : PUNCT ct-10491 161 23 2013 2013 NUM ct-10491 161 24 . . PUNCT ct-10491 161 25 available available ADJ ct-10491 161 26 from from ADP ct-10491 161 27 : : PUNCT ct-10491 161 28 https://www https://www PROPN ct-10491 161 29 / / SYM ct-10491 161 30 zoetis.com zoetis.com NUM ct-10491 161 31 / / SYM ct-10491 161 32 products product NOUN ct-10491 161 33 / / SYM ct-10491 161 34 pages page NOUN ct-10491 161 35 / / SYM ct-10491 161 36 rimadyldvm rimadyldvm NOUN ct-10491 161 37 / / SYM ct-10491 161 38 docs doc NOUN ct-10491 161 39 / / SYM ct-10491 161 40 rimadyl_injectable_pi.pdf rimadyl_injectable_pi.pdf PROPN ct-10491 162 1 [ [ X ct-10491 162 2 cited cite VERB ct-10491 162 3 29 29 NUM ct-10491 162 4 december december PROPN ct-10491 162 5 2022 2022 NUM ct-10491 162 6 ] ] PUNCT ct-10491 162 7 . . PUNCT ct-10491 163 1 10 10 NUM ct-10491 163 2 . . PUNCT ct-10491 164 1 macphail macphail PROPN ct-10491 164 2 cm cm PROPN ct-10491 164 3 , , PUNCT ct-10491 164 4 lappin lappin PROPN ct-10491 164 5 mr mr PROPN ct-10491 164 6 , , PUNCT ct-10491 164 7 meyer meyer PROPN ct-10491 164 8 dj dj PROPN ct-10491 164 9 , , PUNCT ct-10491 164 10 et et PROPN ct-10491 164 11 al al PROPN ct-10491 164 12 : : PUNCT ct-10491 164 13 hepatocellular hepatocellular ADJ ct-10491 164 14 toxicosis toxicosis NOUN ct-10491 164 15 associated associate VERB ct-10491 164 16 with with ADP ct-10491 164 17 administration administration NOUN ct-10491 164 18 of of ADP ct-10491 164 19 carprofen carprofen PROPN ct-10491 164 20 in in ADP ct-10491 164 21 21 21 NUM ct-10491 164 22 dogs dog NOUN ct-10491 164 23 . . PUNCT ct-10491 165 1 j j PROPN ct-10491 165 2 am be AUX ct-10491 165 3 vet vet NOUN ct-10491 165 4 med med ADJ ct-10491 165 5 assoc assoc PROPN ct-10491 165 6 1998;212:1895 1998;212:1895 PROPN ct-10491 165 7 - - PUNCT ct-10491 165 8 1901 1901 NUM ct-10491 165 9 . . PUNCT ct-10491 166 1 doi doi NOUN ct-10491 166 2 : : PUNCT ct-10491 166 3 10.2460 10.2460 NUM ct-10491 166 4 / / SYM ct-10491 166 5 javma.1998.212.12.1895 javma.1998.212.12.1895 PROPN ct-10491 166 6 11 11 NUM ct-10491 166 7 . . PUNCT ct-10491 167 1 lascelles lascelle NOUN ct-10491 167 2 bdx bdx PROPN ct-10491 167 3 , , PUNCT ct-10491 167 4 mcfarland mcfarland PROPN ct-10491 167 5 jm jm PROPN ct-10491 167 6 , , PUNCT ct-10491 167 7 swann swann PROPN ct-10491 167 8 h h PROPN ct-10491 167 9 : : PUNCT ct-10491 167 10 guidelines guideline NOUN ct-10491 167 11 for for ADP ct-10491 167 12 safe safe ADJ ct-10491 167 13 and and CCONJ ct-10491 167 14 effective effective ADJ ct-10491 167 15 use use NOUN ct-10491 167 16 of of ADP ct-10491 167 17 nsaids nsaid NOUN ct-10491 167 18 in in ADP ct-10491 167 19 dogs dog NOUN ct-10491 167 20 . . PUNCT ct-10491 168 1 vet vet NOUN ct-10491 168 2 therap therap NOUN ct-10491 168 3 2005;6:237 2005;6:237 NUM ct-10491 168 4 - - SYM ct-10491 168 5 251 251 NUM ct-10491 168 6 . . PUNCT ct-10491 169 1 12 12 NUM ct-10491 169 2 . . PUNCT ct-10491 170 1 priymenko priymenko PROPN ct-10491 170 2 n n CCONJ ct-10491 170 3 , , PUNCT ct-10491 170 4 garnier garnier PROPN ct-10491 170 5 f f PROPN ct-10491 170 6 , , PUNCT ct-10491 170 7 ferre ferre PROPN ct-10491 170 8 jp jp PROPN ct-10491 170 9 , , PUNCT ct-10491 170 10 et et PROPN ct-10491 170 11 al al PROPN ct-10491 170 12 : : PUNCT ct-10491 170 13 enantioselectivity enantioselectivity NOUN ct-10491 170 14 of of ADP ct-10491 170 15 the the DET ct-10491 170 16 enterohepatic enterohepatic ADJ ct-10491 170 17 recycling recycling NOUN ct-10491 170 18 of of ADP ct-10491 170 19 carprofen carprofen NOUN ct-10491 170 20 in in ADP ct-10491 170 21 the the DET ct-10491 170 22 dog dog NOUN ct-10491 170 23 . . PUNCT ct-10491 171 1 drug drug NOUN ct-10491 171 2 metab metab PROPN ct-10491 171 3 dispos dispos PROPN ct-10491 171 4 1998;26:170 1998;26:170 X ct-10491 171 5 - - SYM ct-10491 171 6 176 176 NUM ct-10491 171 7 . . PUNCT ct-10491 171 8 13 13 NUM ct-10491 171 9 . . PUNCT ct-10491 171 10 messenger messenger PROPN ct-10491 171 11 km km PROPN ct-10491 171 12 , , PUNCT ct-10491 171 13 wofford wofford PROPN ct-10491 171 14 ja ja PROPN ct-10491 171 15 , , PUNCT ct-10491 171 16 papich papich VERB ct-10491 171 17 mg mg PROPN ct-10491 171 18 : : PUNCT ct-10491 171 19 carprofen carprofen NOUN ct-10491 171 20 pharmacokinetics pharmacokinetic NOUN ct-10491 171 21 in in ADP ct-10491 171 22 plasma plasma NOUN ct-10491 171 23 and and CCONJ ct-10491 171 24 in in ADP ct-10491 171 25 control control NOUN ct-10491 171 26 and and CCONJ ct-10491 171 27 inflamed inflamed VERB ct-10491 171 28 canine canine NOUN ct-10491 171 29 tissue tissue NOUN ct-10491 171 30 fluid fluid NOUN ct-10491 171 31 using use VERB ct-10491 171 32 in in ADP ct-10491 171 33 vivo vivo ADJ ct-10491 171 34 ultrafiltration ultrafiltration NOUN ct-10491 171 35 . . PUNCT ct-10491 172 1 j j PROPN ct-10491 172 2 vet vet NOUN ct-10491 172 3 pharmacol pharmacol PROPN ct-10491 172 4 ther ther ADV ct-10491 172 5 2015;39:32 2015;39:32 NUM ct-10491 172 6 - - SYM ct-10491 172 7 39 39 NUM ct-10491 172 8 . . PUNCT ct-10491 173 1 doi doi NOUN ct-10491 173 2 : : PUNCT ct-10491 173 3 10.1111 10.1111 NUM ct-10491 173 4 / / SYM ct-10491 173 5 jvp.12233 jvp.12233 NUM ct-10491 173 6 14 14 NUM ct-10491 173 7 . . PUNCT ct-10491 174 1 clark clark PROPN ct-10491 174 2 tp tp PROPN ct-10491 174 3 , , PUNCT ct-10491 174 4 chieffo chieffo PROPN ct-10491 174 5 c c PROPN ct-10491 174 6 , , PUNCT ct-10491 174 7 huhn huhn PROPN ct-10491 174 8 jc jc PROPN ct-10491 174 9 , , PUNCT ct-10491 174 10 et et PROPN ct-10491 174 11 al al PROPN ct-10491 174 12 : : PUNCT ct-10491 174 13 the the DET ct-10491 174 14 steady steady ADJ ct-10491 174 15 state state NOUN ct-10491 174 16 pharmacokinetics pharmacokinetic NOUN ct-10491 174 17 and and CCONJ ct-10491 174 18 bioequivalence bioequivalence NOUN ct-10491 174 19 of of ADP ct-10491 174 20 carprofen carprofen PROPN ct-10491 174 21 administered administer VERB ct-10491 174 22 orally orally ADV ct-10491 174 23 and and CCONJ ct-10491 174 24 subcutaneously subcutaneously ADV ct-10491 174 25 in in ADP ct-10491 174 26 dogs dog NOUN ct-10491 174 27 . . PUNCT ct-10491 175 1 j j PROPN ct-10491 175 2 vet vet NOUN ct-10491 175 3 pharmacol pharmacol PROPN ct-10491 175 4 ther ther ADV ct-10491 175 5 2003;26:187192 2003;26:187192 NUM ct-10491 175 6 . . PUNCT ct-10491 176 1 doi doi NOUN ct-10491 176 2 : : PUNCT ct-10491 176 3 10.1046 10.1046 NUM ct-10491 176 4 / / SYM ct-10491 176 5 j.1365 j.1365 NOUN ct-10491 176 6 - - PUNCT ct-10491 176 7 2885.2003.00475.x 2885.2003.00475.x NUM ct-10491 176 8 15 15 NUM ct-10491 176 9 . . PUNCT ct-10491 177 1 lipscomb lipscomb PROPN ct-10491 177 2 vj vj PROPN ct-10491 177 3 , , PUNCT ct-10491 177 4 aliabadi aliabadi PROPN ct-10491 177 5 fs f NOUN ct-10491 177 6 , , PUNCT ct-10491 177 7 lees lee NOUN ct-10491 177 8 p p NOUN ct-10491 177 9 , , PUNCT ct-10491 177 10 et et PROPN ct-10491 177 11 al al PROPN ct-10491 177 12 : : PUNCT ct-10491 177 13 clinical clinical ADJ ct-10491 177 14 efficacy efficacy NOUN ct-10491 177 15 and and CCONJ ct-10491 177 16 pharmacokinetics pharmacokinetic NOUN ct-10491 177 17 of of ADP ct-10491 177 18 carprofen carprofen NOUN ct-10491 177 19 in in ADP ct-10491 177 20 the the DET ct-10491 177 21 treatment treatment NOUN ct-10491 177 22 of of ADP ct-10491 177 23 dogs dog NOUN ct-10491 177 24 with with ADP ct-10491 177 25 osteoarthritis osteoarthritis NOUN ct-10491 177 26 . . PUNCT ct-10491 178 1 vet vet NOUN ct-10491 178 2 rec rec X ct-10491 178 3 2002;150:684 2002;150:684 PROPN ct-10491 178 4 - - PUNCT ct-10491 178 5 689 689 NUM ct-10491 178 6 . . PUNCT ct-10491 179 1 doi doi NOUN ct-10491 179 2 : : PUNCT ct-10491 179 3 10.1136 10.1136 NUM ct-10491 179 4 / / SYM ct-10491 179 5 vr.150.22.684 vr.150.22.684 PROPN ct-10491 179 6 16 16 NUM ct-10491 179 7 . . PUNCT ct-10491 180 1 escabor escabor PROPN ct-10491 180 2 sr sr PROPN ct-10491 180 3 , , PUNCT ct-10491 180 4 kolster kolster PROPN ct-10491 180 5 ka ka PROPN ct-10491 180 6 : : PUNCT ct-10491 180 7 analgesia analgesia NOUN ct-10491 180 8 for for ADP ct-10491 180 9 canine canine PROPN ct-10491 180 10 cesarean cesarean PROPN ct-10491 180 11 section section NOUN ct-10491 180 12 recovery recovery NOUN ct-10491 180 13 . . PUNCT ct-10491 180 14     SPACE ct-10491 181 1 clinical clinical ADJ ct-10491 181 2 theriogenology theriogenology NOUN ct-10491 181 3 2016;8:191 2016;8:191 PROPN ct-10491 181 4 - - SYM ct-10491 181 5 195 195 NUM ct-10491 181 6 . . NOUN ct-10491 181 7 17 17 NUM ct-10491 181 8 . . PUNCT ct-10491 182 1 matthews matthews PROPN ct-10491 182 2 ka ka PROPN ct-10491 182 3 : : PUNCT ct-10491 182 4 pain pain NOUN ct-10491 182 5 management management NOUN ct-10491 182 6 for for ADP ct-10491 182 7 the the DET ct-10491 182 8 pregnant pregnant ADJ ct-10491 182 9 , , PUNCT ct-10491 182 10 lactating lactating NOUN ct-10491 182 11 , , PUNCT ct-10491 182 12 and and CCONJ ct-10491 182 13 neonatal neonatal ADJ ct-10491 182 14 to to ADP ct-10491 182 15 pediatric pediatric ADJ ct-10491 182 16 cat cat NOUN ct-10491 182 17 and and CCONJ ct-10491 182 18 dog dog NOUN ct-10491 182 19 . . PUNCT ct-10491 183 1 vet vet NOUN ct-10491 183 2 clin clin PROPN ct-10491 183 3 north north PROPN ct-10491 183 4 am be AUX ct-10491 183 5 small small ADJ ct-10491 183 6 anim anim NOUN ct-10491 183 7 pract pract NOUN ct-10491 183 8 2008;38:1291 2008;38:1291 PROPN ct-10491 183 9 - - PUNCT ct-10491 183 10 1308 1308 NUM ct-10491 183 11 . . PUNCT ct-10491 184 1 doi doi NOUN ct-10491 184 2 : : PUNCT ct-10491 184 3 10.1016 10.1016 NUM ct-10491 184 4 / / SYM ct-10491 184 5 j.cvsm.2008.07.001 j.cvsm.2008.07.001 PROPN ct-10491 184 6 18 18 NUM ct-10491 184 7 . . PUNCT ct-10491 184 8 ferrari ferrari PROPN ct-10491 185 1 d d PROPN ct-10491 185 2 , , PUNCT ct-10491 185 3 lundgren lundgren PROPN ct-10491 185 4 s s PROPN ct-10491 185 5 , , PUNCT ct-10491 185 6 holmberg holmberg PROPN ct-10491 185 7 j j PROPN ct-10491 185 8 , , PUNCT ct-10491 185 9 et et PROPN ct-10491 185 10 al al PROPN ct-10491 185 11 : : PUNCT ct-10491 185 12 concentration concentration NOUN ct-10491 185 13 of of ADP ct-10491 185 14 carprofen carprofen NOUN ct-10491 185 15 in in ADP ct-10491 185 16 the the DET ct-10491 185 17 milk milk NOUN ct-10491 185 18 of of ADP ct-10491 185 19 lactating lactate VERB ct-10491 185 20 bitches bitch NOUN ct-10491 185 21 after after ADP ct-10491 185 22 cesarean cesarean ADJ ct-10491 185 23 section section NOUN ct-10491 185 24 and and CCONJ ct-10491 185 25 during during ADP ct-10491 185 26 inflammatory inflammatory ADJ ct-10491 185 27 conditions condition NOUN ct-10491 185 28 . . PUNCT ct-10491 185 29     SPACE ct-10491 185 30 theriogenology theriogenology NOUN ct-10491 185 31 2022;181 2022;181 NUM ct-10491 185 32 : : PUNCT ct-10491 185 33 59 59 NUM ct-10491 185 34 - - SYM ct-10491 185 35 68 68 NUM ct-10491 185 36 . . PUNCT ct-10491 186 1 doi doi NOUN ct-10491 186 2 : : PUNCT ct-10491 186 3 10.1016 10.1016 NUM ct-10491 186 4 / / SYM ct-10491 186 5 j.theriogenology.2022.01.016 j.theriogenology.2022.01.016 PROPN ct-10491 186 6 19 19 NUM ct-10491 186 7 . . PUNCT ct-10491 186 8 national national ADJ ct-10491 186 9 center center NOUN ct-10491 186 10 for for ADP ct-10491 186 11 biotechnology biotechnology NOUN ct-10491 186 12 information information NOUN ct-10491 186 13 . . PUNCT ct-10491 187 1 drugs drug NOUN ct-10491 187 2 and and CCONJ ct-10491 187 3 lactation lactation NOUN ct-10491 187 4 database database NOUN ct-10491 187 5 ( ( PUNCT ct-10491 187 6 lactmed lactmed ADJ ct-10491 187 7 ) ) PUNCT ct-10491 187 8 ncbi ncbi PROPN ct-10491 187 9 bookshelf bookshelf PROPN ct-10491 187 10 : : PUNCT ct-10491 187 11 2011 2011 NUM ct-10491 187 12 , , PUNCT ct-10491 187 13 march march PROPN ct-10491 187 14 28 28 NUM ct-10491 187 15 . . PUNCT ct-10491 187 16 available available ADJ ct-10491 187 17 from from ADP ct-10491 187 18 : : PUNCT ct-10491 187 19 https://www.ncbi.nlm.nih.gov/books/ https://www.ncbi.nlm.nih.gov/books/ PROPN ct-10491 187 20 nbk501922/ nbk501922/ PROPN ct-10491 188 1 [ [ X ct-10491 188 2 cited cite VERB ct-10491 188 3 31 31 NUM ct-10491 188 4 december december PROPN ct-10491 188 5 2022 2022 NUM ct-10491 188 6 ] ] PUNCT ct-10491 188 7 . . PUNCT ct-10491 189 1 20 20 NUM ct-10491 189 2 . . PUNCT ct-10491 189 3 anderson anderson PROPN ct-10491 189 4 po po PROPN ct-10491 189 5 , , PUNCT ct-10491 189 6 sauberan sauberan NOUN ct-10491 189 7 jb jb PROPN ct-10491 189 8 : : PUNCT ct-10491 189 9 modeling model VERB ct-10491 189 10 drug drug NOUN ct-10491 189 11 passage passage NOUN ct-10491 189 12 into into ADP ct-10491 189 13 human human ADJ ct-10491 189 14 milk milk NOUN ct-10491 189 15 . . PUNCT ct-10491 190 1 online online PROPN ct-10491 190 2 wiley wiley PROPN ct-10491 190 3 library library PROPN ct-10491 190 4 2016;100:42 2016;100:42 NUM ct-10491 190 5 - - SYM ct-10491 190 6 52 52 NUM ct-10491 190 7 . . PUNCT ct-10491 191 1 doi doi NOUN ct-10491 191 2 : : PUNCT ct-10491 191 3 10.1002 10.1002 NUM ct-10491 191 4 / / SYM ct-10491 191 5 cpt.377 cpt.377 NOUN ct-10491 191 6 21 21 NUM ct-10491 191 7 . . PUNCT ct-10491 192 1 begg begg PROPN ct-10491 192 2 ej ej PROPN ct-10491 192 3 , , PUNCT ct-10491 192 4 atkinson atkinson PROPN ct-10491 192 5 hc hc PROPN ct-10491 192 6 : : PUNCT ct-10491 192 7 modelling modelling NOUN ct-10491 192 8 of of ADP ct-10491 192 9 the the DET ct-10491 192 10 passage passage NOUN ct-10491 192 11 of of ADP ct-10491 192 12 drugs drug NOUN ct-10491 192 13 into into ADP ct-10491 192 14 milk milk NOUN ct-10491 192 15 . . PUNCT ct-10491 193 1 pharmacol pharmacol VERB ct-10491 193 2 ther ther ADV ct-10491 193 3 1993;59:301 1993;59:301 PROPN ct-10491 193 4 - - SYM ct-10491 193 5 310 310 NUM ct-10491 193 6 . . PUNCT ct-10491 194 1 doi doi NOUN ct-10491 194 2 : : PUNCT ct-10491 194 3 10.1016/ 10.1016/ NUM ct-10491 194 4 0163 0163 NUM ct-10491 194 5 - - PUNCT ct-10491 194 6 7258(93)90072 7258(93)90072 NUM ct-10491 194 7 - - PUNCT ct-10491 194 8 l l NOUN ct-10491 194 9 22 22 NUM ct-10491 194 10 . . PUNCT ct-10491 195 1 atkinson atkinson PROPN ct-10491 195 2 hc hc PROPN ct-10491 195 3 , , PUNCT ct-10491 195 4 begg begg PROPN ct-10491 195 5 ej ej PROPN ct-10491 195 6 : : PUNCT ct-10491 195 7 prediction prediction NOUN ct-10491 195 8 of of ADP ct-10491 195 9 drug drug NOUN ct-10491 195 10 distribution distribution NOUN ct-10491 195 11 into into ADP ct-10491 195 12 human human ADJ ct-10491 195 13 milk milk NOUN ct-10491 195 14 from from ADP ct-10491 195 15 physicochemical physicochemical ADJ ct-10491 195 16 characteristics characteristic NOUN ct-10491 195 17 . . PUNCT ct-10491 196 1 clin clin PROPN ct-10491 196 2 pharmacol pharmacol PROPN ct-10491 196 3 1990;18:151 1990;18:151 PROPN ct-10491 196 4 - - PUNCT ct-10491 196 5 167 167 NUM ct-10491 196 6 . . PUNCT ct-10491 197 1 doi doi NOUN ct-10491 197 2 : : PUNCT ct-10491 197 3 10.2165/00003088 10.2165/00003088 NUM ct-10491 197 4 - - PUNCT ct-10491 197 5 199018020 199018020 NUM ct-10491 197 6 - - SYM ct-10491 197 7 00005 00005 NUM ct-10491 197 8 23 23 NUM ct-10491 197 9 . . PUNCT ct-10491 198 1 stebler stebler PROPN ct-10491 198 2 t t PROPN ct-10491 198 3 , , PUNCT ct-10491 198 4 guentert guentert VERB ct-10491 198 5 tw tw NOUN ct-10491 198 6 : : PUNCT ct-10491 198 7 binding bind VERB ct-10491 198 8 of of ADP ct-10491 198 9 drugs drug NOUN ct-10491 198 10 in in ADP ct-10491 198 11 milk milk NOUN ct-10491 198 12 : : PUNCT ct-10491 198 13 the the DET ct-10491 198 14 role role NOUN ct-10491 198 15 of of ADP ct-10491 198 16 casein casein NOUN ct-10491 198 17 in in ADP ct-10491 198 18 milk milk NOUN ct-10491 198 19 protein protein NOUN ct-10491 198 20 binding bind VERB ct-10491 198 21 . . PUNCT ct-10491 199 1 pharmacol pharmacol NOUN ct-10491 199 2 res re NOUN ct-10491 199 3 1990;7:633 1990;7:633 NOUN ct-10491 199 4 - - SYM ct-10491 199 5 637 637 NUM ct-10491 199 6 . . PUNCT ct-10491 200 1 doi doi NOUN ct-10491 200 2 : : PUNCT ct-10491 200 3 10.1023 10.1023 NUM ct-10491 200 4 / / SYM ct-10491 200 5 a:1015826413335 a:1015826413335 NOUN ct-10491 200 6 24 24 NUM ct-10491 200 7 . . PUNCT ct-10491 201 1 stelwagen stelwagen PROPN ct-10491 201 2 k k PROPN ct-10491 201 3 , , PUNCT ct-10491 201 4 singh singh PROPN ct-10491 201 5 k k NOUN ct-10491 201 6 : : PUNCT ct-10491 201 7 the the DET ct-10491 201 8 role role NOUN ct-10491 201 9 of of ADP ct-10491 201 10 tight tight ADJ ct-10491 201 11 junctions junction NOUN ct-10491 201 12 in in ADP ct-10491 201 13 mammary mammary ADJ ct-10491 201 14 gland gland NOUN ct-10491 201 15 function function NOUN ct-10491 201 16 . . PUNCT ct-10491 202 1 j j PROPN ct-10491 202 2 mammary mammary ADJ ct-10491 202 3 gland gland NOUN ct-10491 202 4 biol biol PROPN ct-10491 202 5 neoplasia neoplasia NOUN ct-10491 202 6 2014;19 2014;19 NOUN ct-10491 202 7 : : PUNCT ct-10491 202 8 131 131 NUM ct-10491 202 9 - - SYM ct-10491 202 10 138 138 NUM ct-10491 202 11 . . PUNCT ct-10491 203 1 doi doi NOUN ct-10491 203 2 : : PUNCT ct-10491 203 3 10.1007 10.1007 NUM ct-10491 203 4 / / SYM ct-10491 203 5 s10911 s10911 NOUN ct-10491 203 6 - - PUNCT ct-10491 203 7 013 013 NUM ct-10491 203 8 - - PUNCT ct-10491 203 9 9309 9309 NUM ct-10491 203 10 - - SYM ct-10491 203 11 1 1 NUM ct-10491 203 12 25 25 NUM ct-10491 203 13 . . PUNCT ct-10491 204 1 ette ette PROPN ct-10491 204 2 ei ei PROPN ct-10491 204 3 , , PUNCT ct-10491 204 4 williams williams PROPN ct-10491 204 5 pj pj PROPN ct-10491 204 6 : : PUNCT ct-10491 204 7 population population PROPN ct-10491 204 8 pharmacokinetics pharmacokinetic NOUN ct-10491 204 9 ii ii PROPN ct-10491 204 10 : : PUNCT ct-10491 204 11 estimation estimation NOUN ct-10491 204 12 methods method NOUN ct-10491 204 13 . . PUNCT ct-10491 205 1 ann ann PROPN ct-10491 205 2 pharm pharm PROPN ct-10491 205 3 2004;38:1907 2004;38:1907 PROPN ct-10491 205 4 - - SYM ct-10491 205 5 1915 1915 NUM ct-10491 205 6 . . PUNCT ct-10491 206 1 doi doi NOUN ct-10491 206 2 : : PUNCT ct-10491 206 3 10.1345/ 10.1345/ NUM ct-10491 206 4 aph.1e259 aph.1e259 VERB ct-10491 206 5 http://dx.doi.org/10.58292/ct.v16.10491 http://dx.doi.org/10.58292/ct.v16.10491 NOUN ct-10491 206 6 https://doi.org/10.1002/bdd.2510110704 https://doi.org/10.1002/bdd.2510110704 PROPN ct-10491 206 7 https://doi.org/10.1002/bdd.2510110704 https://doi.org/10.1002/bdd.2510110704 PROPN ct-10491 206 8 https://cdn.ymaws.com/www.aavpt.org/resource/resmgr/imported/carprofen.pdf https://cdn.ymaws.com/www.aavpt.org/resource/resmgr/imported/carprofen.pdf PROPN ct-10491 206 9 https://cdn.ymaws.com/www.aavpt.org/resource/resmgr/imported/carprofen.pdf https://cdn.ymaws.com/www.aavpt.org/resource/resmgr/imported/carprofen.pdf PROPN ct-10491 206 10 https://cdn.ymaws.com/www.aavpt.org/resource/resmgr/imported/carprofen.pdf https://cdn.ymaws.com/www.aavpt.org/resource/resmgr/imported/carprofen.pdf PROPN ct-10491 206 11 https://doi.org/10.1111/j.1467-2995.2011.00675.x https://doi.org/10.1111/j.1467-2995.2011.00675.x NOUN ct-10491 206 12 https://doi.org/10.2460/ajvr.1998.59.11.1441 https://doi.org/10.2460/ajvr.1998.59.11.1441 NUM ct-10491 206 13 https://doi.org/10.2460/ajvr.2004.65.810 https://doi.org/10.2460/ajvr.2004.65.810 NOUN ct-10491 206 14 https://doi.org/10.2460/javma.228.6.876 https://doi.org/10.2460/javma.228.6.876 X ct-10491 206 15 https://doi.org/10.2460/javma.228.6.876 https://doi.org/10.2460/javma.228.6.876 X ct-10491 206 16 https://doi.org/10.2460/javma.2005.227.1112 https://doi.org/10.2460/javma.2005.227.1112 PROPN ct-10491 206 17 https://doi.org/10.1111/j.1365-2885.1994.tb00276.x https://doi.org/10.1111/j.1365-2885.1994.tb00276.x PROPN ct-10491 206 18 http://zoetis.com/products/pages/rimadyldvm/docs/rimadyl_injectable_pi.pdf http://zoetis.com/products/pages/rimadyldvm/docs/rimadyl_injectable_pi.pdf PROPN ct-10491 206 19 http://zoetis.com/products/pages/rimadyldvm/docs/rimadyl_injectable_pi.pdf http://zoetis.com/products/pages/rimadyldvm/docs/rimadyl_injectable_pi.pdf PROPN ct-10491 206 20 https://doi.org/10.2460/javma.1998.212.12.1895 https://doi.org/10.2460/javma.1998.212.12.1895 PROPN ct-10491 206 21 https://doi.org/10.1111/jvp.12233 https://doi.org/10.1111/jvp.12233 ADJ ct-10491 206 22 https://doi.org/10.1046/j.1365-2885.2003.00475.x https://doi.org/10.1046/j.1365-2885.2003.00475.x NOUN ct-10491 206 23 https://doi.org/10.1136/vr.150.22.684 https://doi.org/10.1136/vr.150.22.684 NOUN ct-10491 206 24 https://doi.org/10.1016/j.cvsm.2008.07.001 https://doi.org/10.1016/j.cvsm.2008.07.001 NOUN ct-10491 206 25 https://doi.org/10.1016/j.theriogenology.2022.01.016 https://doi.org/10.1016/j.theriogenology.2022.01.016 PROPN ct-10491 206 26 https://www.ncbi.nlm.nih.gov/books/nbk501922/ https://www.ncbi.nlm.nih.gov/books/nbk501922/ PROPN ct-10491 206 27 https://www.ncbi.nlm.nih.gov/books/nbk501922/ https://www.ncbi.nlm.nih.gov/books/nbk501922/ PROPN ct-10491 206 28 https://doi.org/10.1002/cpt.377 https://doi.org/10.1002/cpt.377 PROPN ct-10491 206 29 https://doi.org/10.1016/0163-7258(93)90072-l https://doi.org/10.1016/0163-7258(93)90072-l PROPN ct-10491 206 30 https://doi.org/10.1016/0163-7258(93)90072-l https://doi.org/10.1016/0163-7258(93)90072-l PROPN ct-10491 206 31 https://doi.org/10.2165/00003088-199018020-00005 https://doi.org/10.2165/00003088-199018020-00005 PUNCT ct-10491 206 32 https://doi.org/10.1023/a:1015826413335 https://doi.org/10.1023/a:1015826413335 NOUN ct-10491 206 33 https://doi.org/10.1007/s10911-013-9309-1 https://doi.org/10.1007/s10911-013-9309-1 NUM ct-10491 206 34 https://doi.org/10.1345/aph.1e259 https://doi.org/10.1345/aph.1e259 PROPN ct-10491 206 35 https://doi.org/10.1345/aph.1e259 https://doi.org/10.1345/aph.1e259 PROPN ct-10491 206 36 citation citation NOUN ct-10491 206 37 : : PUNCT ct-10491 206 38 clinical clinical ADJ ct-10491 206 39 theriogenology theriogenology NOUN ct-10491 206 40 2024 2024 NUM ct-10491 206 41 , , PUNCT ct-10491 206 42 16 16 NUM ct-10491 206 43 , , PUNCT ct-10491 206 44 10491 10491 NUM ct-10491 206 45 , , PUNCT ct-10491 206 46 http://dx.doi.org/10.58292/ct.v16.10491 http://dx.doi.org/10.58292/ct.v16.10491 NOUN ct-10491 206 47 7 7 NUM ct-10491 206 48 26 26 NUM ct-10491 206 49 . . PUNCT ct-10491 207 1 xu xu PROPN ct-10491 207 2 jj jj PROPN ct-10491 207 3 , , PUNCT ct-10491 207 4 renner renner PROPN ct-10491 207 5 dm dm PROPN ct-10491 207 6 , , PUNCT ct-10491 207 7 lester lester PROPN ct-10491 207 8 pa pa PROPN ct-10491 207 9 : : PUNCT ct-10491 207 10 strength strength NOUN ct-10491 207 11 and and CCONJ ct-10491 207 12 sterility sterility NOUN ct-10491 207 13 of of ADP ct-10491 207 14 stock stock NOUN ct-10491 207 15 and and CCONJ ct-10491 207 16 diluted dilute VERB ct-10491 207 17 carprofen carprofen NOUN ct-10491 207 18 over over ADP ct-10491 207 19 time time NOUN ct-10491 207 20 . . PUNCT ct-10491 208 1 j j PROPN ct-10491 208 2 am be AUX ct-10491 208 3 assoc assoc PROPN ct-10491 208 4 lab lab PROPN ct-10491 208 5 anim anim NOUN ct-10491 208 6 sci sci PROPN ct-10491 208 7 2021;60 2021;60 NOUN ct-10491 208 8 : : PUNCT ct-10491 208 9 470 470 NUM ct-10491 208 10 - - SYM ct-10491 208 11 474 474 NUM ct-10491 208 12 . . PUNCT ct-10491 209 1 doi doi NOUN ct-10491 209 2 : : PUNCT ct-10491 209 3 10.30802 10.30802 NUM ct-10491 209 4 / / SYM ct-10491 209 5 aalas aalas PROPN ct-10491 209 6 - - PUNCT ct-10491 209 7 jaalas-20 jaalas-20 PROPN ct-10491 209 8 - - PUNCT ct-10491 209 9 000102 000102 NUM ct-10491 209 10 27 27 NUM ct-10491 209 11 . . PUNCT ct-10491 210 1 united united PROPN ct-10491 210 2 states states PROPN ct-10491 210 3 pharmacopeia pharmacopeia PROPN ct-10491 210 4 ( ( PUNCT ct-10491 210 5 usp usp NOUN ct-10491 210 6 - - PUNCT ct-10491 210 7 nf nf NOUN ct-10491 210 8 ) ) PUNCT ct-10491 210 9 . . PUNCT ct-10491 211 1 usp usp PROPN ct-10491 211 2 34 34 NUM ct-10491 211 3 - - PUNCT ct-10491 211 4 nf29 nf29 PROPN ct-10491 211 5 . . PUNCT ct-10491 212 1 general general ADJ ct-10491 212 2 chapter chapter NOUN ct-10491 212 3 on on ADP ct-10491 212 4 validation validation NOUN ct-10491 212 5 of of ADP ct-10491 212 6 compendial compendial ADJ ct-10491 212 7 methods method NOUN ct-10491 212 8 < < X ct-10491 212 9 1225 1225 NUM ct-10491 212 10 > > X ct-10491 212 11 . . PUNCT ct-10491 213 1 rockville rockville PROPN ct-10491 213 2 , , PUNCT ct-10491 213 3 md md PROPN ct-10491 213 4 ; ; PUNCT ct-10491 213 5 united united PROPN ct-10491 213 6 states states PROPN ct-10491 213 7 pharmacopeial pharmacopeial ADJ ct-10491 213 8 convention convention NOUN ct-10491 213 9 : : PUNCT ct-10491 213 10 2011 2011 NUM ct-10491 213 11 . . PUNCT ct-10491 214 1 available available ADJ ct-10491 214 2 from from ADP ct-10491 214 3 : : PUNCT ct-10491 214 4 https://cdn.ymaws.com/www.aavpt.org/resource/resmgr/ https://cdn.ymaws.com/www.aavpt.org/resource/resmgr/ PROPN ct-10491 214 5 imported import VERB ct-10491 214 6 / / SYM ct-10491 214 7 carprofen.pdf carprofen.pdf NOUN ct-10491 214 8 [ [ X ct-10491 214 9 cited cite VERB ct-10491 214 10 4 4 NUM ct-10491 214 11 february february NOUN ct-10491 214 12 2023 2023 NUM ct-10491 214 13 ] ] PUNCT ct-10491 214 14 . . PUNCT ct-10491 215 1 28 28 NUM ct-10491 215 2 . . PUNCT ct-10491 216 1 derendorf derendorf PROPN ct-10491 216 2 h h PROPN ct-10491 216 3 , , PUNCT ct-10491 216 4 meibohm meibohm PROPN ct-10491 216 5 a a PRON ct-10491 216 6 : : PUNCT ct-10491 216 7 modeling modeling NOUN ct-10491 216 8 of of ADP ct-10491 216 9 pharmacokinetic pharmacokinetic ADJ ct-10491 216 10 / / SYM ct-10491 216 11 pharmacodynamic pharmacodynamic ADJ ct-10491 216 12 ( ( PUNCT ct-10491 216 13 pk pk NOUN ct-10491 216 14 / / SYM ct-10491 216 15 pd pd NOUN ct-10491 216 16 ) ) PUNCT ct-10491 216 17 relationships relationship NOUN ct-10491 216 18 : : PUNCT ct-10491 216 19 concepts concept NOUN ct-10491 216 20 and and CCONJ ct-10491 216 21 perspectives perspective NOUN ct-10491 216 22 . . PUNCT ct-10491 217 1 pharmacol pharmacol PROPN ct-10491 217 2 res res PROPN ct-10491 217 3 1999;16:176 1999;16:176 PROPN ct-10491 217 4 - - PUNCT ct-10491 217 5 185 185 NUM ct-10491 217 6 . . PUNCT ct-10491 218 1 doi doi NOUN ct-10491 218 2 : : PUNCT ct-10491 218 3 10.1023 10.1023 NUM ct-10491 218 4 / / SYM ct-10491 218 5 a:1011907920641 a:1011907920641 PROPN ct-10491 218 6 29 29 NUM ct-10491 218 7 . . PUNCT ct-10491 219 1 wright wright PROPN ct-10491 219 2 jd jd PROPN ct-10491 219 3 , , PUNCT ct-10491 219 4 boudinot boudinot ADV ct-10491 219 5 fd fd PROPN ct-10491 219 6 , , PUNCT ct-10491 219 7 ujhelyi ujhelyi PROPN ct-10491 219 8 mr mr PROPN ct-10491 219 9 : : PUNCT ct-10491 219 10 measurement measurement NOUN ct-10491 219 11 and and CCONJ ct-10491 219 12 analysis analysis NOUN ct-10491 219 13 of of ADP ct-10491 219 14 unbound unbound NOUN ct-10491 219 15 drug drug NOUN ct-10491 219 16 concentrations concentration NOUN ct-10491 219 17 . . PUNCT ct-10491 220 1 clin clin PROPN ct-10491 220 2 pharmacol pharmacol PROPN ct-10491 220 3 1996;30 1996;30 NUM ct-10491 220 4 : : PUNCT ct-10491 220 5 445 445 NUM ct-10491 220 6 - - SYM ct-10491 220 7 462 462 NUM ct-10491 220 8 . . PUNCT ct-10491 221 1 doi doi NOUN ct-10491 221 2 : : PUNCT ct-10491 221 3 10.2165/00003088 10.2165/00003088 NUM ct-10491 221 4 - - PUNCT ct-10491 221 5 199630060 199630060 NUM ct-10491 221 6 - - SYM ct-10491 221 7 00003 00003 NUM ct-10491 221 8 30 30 NUM ct-10491 221 9 . . PUNCT ct-10491 222 1 bidgood bidgood PROPN ct-10491 222 2 t t PROPN ct-10491 222 3 , , PUNCT ct-10491 222 4 papich papich VERB ct-10491 222 5 mg mg NOUN ct-10491 222 6 : : PUNCT ct-10491 222 7 plasma plasma VERB ct-10491 222 8 pharmacokinetics pharmacokinetic NOUN ct-10491 222 9 and and CCONJ ct-10491 222 10 tissue tissue NOUN ct-10491 222 11 fluid fluid NOUN ct-10491 222 12 concentrations concentration NOUN ct-10491 222 13 of of ADP ct-10491 222 14 meropenem meropenem PROPN ct-10491 222 15 after after ADP ct-10491 222 16 intravenous intravenous ADJ ct-10491 222 17 and and CCONJ ct-10491 222 18 subcutaneous subcutaneous ADJ ct-10491 222 19 administration administration NOUN ct-10491 222 20 in in ADP ct-10491 222 21 dogs dog NOUN ct-10491 222 22 . . PUNCT ct-10491 223 1 am be AUX ct-10491 223 2 j j PROPN ct-10491 223 3 vet vet NOUN ct-10491 223 4 res re NOUN ct-10491 223 5 2002;63:1622 2002;63:1622 NUM ct-10491 223 6 - - PUNCT ct-10491 223 7 1628 1628 NUM ct-10491 223 8 . . PUNCT ct-10491 224 1 doi doi NOUN ct-10491 224 2 : : PUNCT ct-10491 224 3 10.2460 10.2460 NUM ct-10491 224 4 / / SYM ct-10491 224 5 ajvr.2002.63.1622 ajvr.2002.63.1622 PROPN ct-10491 224 6 31 31 NUM ct-10491 224 7 . . PUNCT ct-10491 225 1 kimura kimura PROPN ct-10491 225 2 t t PROPN ct-10491 225 3 , , PUNCT ct-10491 225 4 kotani kotani PROPN ct-10491 226 1 k k NOUN ct-10491 226 2 : : PUNCT ct-10491 226 3 perinatal perinatal ADJ ct-10491 226 4 veterinary veterinary ADJ ct-10491 226 5 medicine medicine NOUN ct-10491 226 6 - - PUNCT ct-10491 226 7 related relate VERB ct-10491 226 8 evaluation evaluation NOUN ct-10491 226 9 in in ADP ct-10491 226 10 hematological hematological NOUN ct-10491 226 11 and and CCONJ ct-10491 226 12 serum serum VERB ct-10491 226 13 biochemical biochemical ADJ ct-10491 226 14 profiles profile NOUN ct-10491 226 15 of of ADP ct-10491 226 16 experimental experimental ADJ ct-10491 226 17 beagles beagle NOUN ct-10491 226 18 throughout throughout ADP ct-10491 226 19 pregnancy pregnancy NOUN ct-10491 226 20 and and CCONJ ct-10491 226 21 parturition parturition NOUN ct-10491 226 22 . . PUNCT ct-10491 227 1 animal animal NOUN ct-10491 227 2 model model NOUN ct-10491 227 3 exp exp NOUN ct-10491 227 4 med med PROPN ct-10491 227 5 2018;1:282 2018;1:282 PROPN ct-10491 227 6 - - PUNCT ct-10491 227 7 294 294 NUM ct-10491 227 8 . . PUNCT ct-10491 227 9     SPACE ct-10491 228 1 doi doi NOUN ct-10491 228 2 : : PUNCT ct-10491 228 3 10.1002 10.1002 NUM ct-10491 228 4 / / SYM ct-10491 228 5 ame2.12043 ame2.12043 NOUN ct-10491 228 6 32 32 NUM ct-10491 228 7 . . PUNCT ct-10491 229 1 jeong jeong PROPN ct-10491 229 2 h h PROPN ct-10491 229 3 : : PUNCT ct-10491 229 4 altered alter VERB ct-10491 229 5 drug drug NOUN ct-10491 229 6 metabolism metabolism NOUN ct-10491 229 7 during during ADP ct-10491 229 8 pregnancy pregnancy NOUN ct-10491 229 9 : : PUNCT ct-10491 229 10 hormonal hormonal ADJ ct-10491 229 11 regulation regulation NOUN ct-10491 229 12 of of ADP ct-10491 229 13 drug drug NOUN ct-10491 229 14 - - PUNCT ct-10491 229 15 metabolizing metabolize VERB ct-10491 229 16 enzymes enzyme NOUN ct-10491 229 17 . . PUNCT ct-10491 230 1 expert expert NOUN ct-10491 230 2 opin opin NOUN ct-10491 230 3 drug drug NOUN ct-10491 230 4 metab metab NOUN ct-10491 230 5 toxicol toxicol NOUN ct-10491 230 6 2010;6:689 2010;6:689 PROPN ct-10491 230 7 - - PUNCT ct-10491 230 8 699 699 NUM ct-10491 230 9 . . PUNCT ct-10491 231 1 doi doi NOUN ct-10491 231 2 : : PUNCT ct-10491 231 3 10.1517/17425251003677755 10.1517/17425251003677755 NUM ct-10491 231 4 33 33 NUM ct-10491 231 5 . . PUNCT ct-10491 232 1 lascelles lascelle NOUN ct-10491 232 2 bdx bdx PROPN ct-10491 232 3 , , PUNCT ct-10491 232 4 cripps cripps PROPN ct-10491 232 5 pj pj PROPN ct-10491 232 6 , , PUNCT ct-10491 232 7 jones jones PROPN ct-10491 232 8 a a PROPN ct-10491 232 9 , , PUNCT ct-10491 232 10 et et PROPN ct-10491 232 11 al al PROPN ct-10491 232 12 : : PUNCT ct-10491 232 13 efficacy efficacy NOUN ct-10491 232 14 and and CCONJ ct-10491 232 15 kinetics kinetic NOUN ct-10491 232 16 of of ADP ct-10491 232 17 carprofen carprofen PROPN ct-10491 232 18 , , PUNCT ct-10491 232 19 administered administer VERB ct-10491 232 20 preoperatively preoperatively ADV ct-10491 232 21 or or CCONJ ct-10491 232 22 postoperatively postoperatively ADJ ct-10491 232 23 , , PUNCT ct-10491 232 24 for for ADP ct-10491 232 25 the the DET ct-10491 232 26 prevention prevention NOUN ct-10491 232 27 of of ADP ct-10491 232 28 pain pain NOUN ct-10491 232 29 in in ADP ct-10491 232 30 dogs dog NOUN ct-10491 232 31 undergoing undergo VERB ct-10491 232 32 ovariohysterectomy ovariohysterectomy ADV ct-10491 232 33 . . PUNCT ct-10491 233 1 vet vet NOUN ct-10491 233 2 surg surg NOUN ct-10491 233 3 1998;27:568 1998;27:568 PROPN ct-10491 233 4 - - PUNCT ct-10491 233 5 582 582 NUM ct-10491 233 6 . . PUNCT ct-10491 234 1 doi doi NOUN ct-10491 234 2 : : PUNCT ct-10491 234 3 10.1111 10.1111 NUM ct-10491 234 4 / / SYM ct-10491 234 5 j.1532 j.1532 PROPN ct-10491 234 6 - - PUNCT ct-10491 234 7 950x.1998 950x.1998 NOUN ct-10491 234 8 . . PUNCT ct-10491 235 1 tb00533.x tb00533.x PROPN ct-10491 235 2 34 34 NUM ct-10491 235 3 . . PUNCT ct-10491 236 1 johnston johnston PROPN ct-10491 236 2 sd sd PROPN ct-10491 236 3 , , PUNCT ct-10491 236 4 root root NOUN ct-10491 236 5 kustritz kustritz PROPN ct-10491 236 6 mv mv PROPN ct-10491 236 7 , , PUNCT ct-10491 236 8 olson olson NOUN ct-10491 236 9 ps ps PROPN ct-10491 236 10 : : PUNCT ct-10491 236 11 canine canine VERB ct-10491 236 12 and and CCONJ ct-10491 236 13 feline feline ADJ ct-10491 236 14 theriogenology theriogenology NOUN ct-10491 236 15 . . PUNCT ct-10491 237 1 1st 1st PROPN ct-10491 237 2 edition edition PROPN ct-10491 237 3 , , PUNCT ct-10491 237 4 philadelphia philadelphia PROPN ct-10491 237 5 ; ; PUNCT ct-10491 237 6 saunders saunder NOUN ct-10491 237 7 : : PUNCT ct-10491 237 8 2001 2001 NUM ct-10491 237 9 . . PUNCT ct-10491 238 1 p. p. NOUN ct-10491 238 2 139 139 NUM ct-10491 238 3 . . PUNCT ct-10491 238 4 35 35 NUM ct-10491 238 5 . . X ct-10491 239 1 oukessou oukessou PROPN ct-10491 239 2 m m PROPN ct-10491 239 3 , , PUNCT ct-10491 239 4 benlamith benlamith PROPN ct-10491 239 5 s s PART ct-10491 239 6 : : PUNCT ct-10491 239 7 benzylpenicillin benzylpenicillin NOUN ct-10491 239 8 kinetics kinetic NOUN ct-10491 239 9 in in ADP ct-10491 239 10 the the DET ct-10491 239 11 ewe ewe PROPN ct-10491 239 12 : : PUNCT ct-10491 239 13 influence influence NOUN ct-10491 239 14 of of ADP ct-10491 239 15 pregnancy pregnancy NOUN ct-10491 239 16 and and CCONJ ct-10491 239 17 lactation lactation NOUN ct-10491 239 18 . . PUNCT ct-10491 240 1 res re NOUN ct-10491 240 2 vet vet NOUN ct-10491 240 3 sci sci PROPN ct-10491 240 4 1990;49 1990;49 NUM ct-10491 240 5 : : PUNCT ct-10491 240 6 190 190 NUM ct-10491 240 7 - - PUNCT ct-10491 240 8 193 193 NUM ct-10491 240 9 . . PUNCT ct-10491 241 1 doi doi NOUN ct-10491 241 2 : : PUNCT ct-10491 241 3 10.1016 10.1016 NUM ct-10491 241 4 / / SYM ct-10491 241 5 s0034 s0034 NOUN ct-10491 241 6 - - PUNCT ct-10491 241 7 5288(18)31075 5288(18)31075 NUM ct-10491 241 8 - - PUNCT ct-10491 241 9 0 0 NUM ct-10491 241 10 36 36 NUM ct-10491 241 11 . . PUNCT ct-10491 242 1 johnston johnston PROPN ct-10491 242 2 sd sd PROPN ct-10491 242 3 , , PUNCT ct-10491 242 4 root root NOUN ct-10491 242 5 kustritz kustritz PROPN ct-10491 242 6 mv mv PROPN ct-10491 242 7 , , PUNCT ct-10491 242 8 olson olson NOUN ct-10491 242 9 ps ps PROPN ct-10491 242 10 : : PUNCT ct-10491 242 11 canine canine VERB ct-10491 242 12 and and CCONJ ct-10491 242 13 feline feline ADJ ct-10491 242 14 theriogenology theriogenology NOUN ct-10491 242 15 . . PUNCT ct-10491 243 1 1st 1st PROPN ct-10491 243 2 edition edition PROPN ct-10491 243 3 , , PUNCT ct-10491 243 4 philadelphia philadelphia PROPN ct-10491 243 5 ; ; PUNCT ct-10491 243 6 saunders saunder NOUN ct-10491 243 7 : : PUNCT ct-10491 243 8 2001 2001 NUM ct-10491 243 9 . . PUNCT ct-10491 244 1 p. p. NOUN ct-10491 244 2 71 71 NUM ct-10491 244 3 - - SYM ct-10491 244 4 72 72 NUM ct-10491 244 5 . . PUNCT ct-10491 245 1 37 37 NUM ct-10491 245 2 . . PUNCT ct-10491 245 3 messenger messenger PROPN ct-10491 245 4 km km PROPN ct-10491 245 5 , , PUNCT ct-10491 245 6 papich papich VERB ct-10491 245 7 mg mg PROPN ct-10491 245 8 : : PUNCT ct-10491 245 9 the the DET ct-10491 245 10 influence influence NOUN ct-10491 245 11 of of ADP ct-10491 245 12 cefovecin cefovecin NOUN ct-10491 245 13 on on ADP ct-10491 245 14 the the DET ct-10491 245 15 enantioselective enantioselective ADJ ct-10491 245 16 pharmacokinetics pharmacokinetic NOUN ct-10491 245 17 of of ADP ct-10491 245 18 carprofen carprofen NOUN ct-10491 245 19 in in ADP ct-10491 245 20 dogs dog NOUN ct-10491 245 21 . . PUNCT ct-10491 246 1 j j PROPN ct-10491 246 2 vet vet NOUN ct-10491 246 3 intern intern NOUN ct-10491 246 4 med med PROPN ct-10491 246 5 2013;27:749 2013;27:749 PROPN ct-10491 246 6 . . PUNCT ct-10491 247 1 38 38 NUM ct-10491 247 2 . . PUNCT ct-10491 248 1 ling ling PROPN ct-10491 248 2 b b PROPN ct-10491 248 3 , , PUNCT ct-10491 248 4 alcorn alcorn PROPN ct-10491 248 5 j j PROPN ct-10491 248 6 : : PUNCT ct-10491 248 7 lactation lactation NOUN ct-10491 248 8 stage stage NOUN ct-10491 248 9 influences influence VERB ct-10491 248 10 drug drug NOUN ct-10491 248 11 milk milk NOUN ct-10491 248 12 - - PUNCT ct-10491 248 13 to to ADP ct-10491 248 14 - - PUNCT ct-10491 248 15 serum serum NOUN ct-10491 248 16 values value NOUN ct-10491 248 17 and and CCONJ ct-10491 248 18 neonatal neonatal ADJ ct-10491 248 19 exposure exposure NOUN ct-10491 248 20 risk risk NOUN ct-10491 248 21 . . PUNCT ct-10491 249 1 int int NOUN ct-10491 249 2 j j PROPN ct-10491 249 3 toxicol toxicol PROPN ct-10491 249 4 2010;29:411 2010;29:411 PROPN ct-10491 249 5 - - PUNCT ct-10491 249 6 417 417 NUM ct-10491 249 7 . . PUNCT ct-10491 250 1 doi doi NOUN ct-10491 250 2 : : PUNCT ct-10491 250 3 10.1177/1091581810367949 10.1177/1091581810367949 NUM ct-10491 250 4 http://dx.doi.org/10.58292/ct.v16.10491 http://dx.doi.org/10.58292/ct.v16.10491 NOUN ct-10491 250 5 https://doi.org/10.30802/aalas-jaalas-20-000102 https://doi.org/10.30802/aalas-jaalas-20-000102 NOUN ct-10491 250 6 https://cdn.ymaws.com/www.aavpt.org/resource/resmgr/imported/carprofen.pdf https://cdn.ymaws.com/www.aavpt.org/resource/resmgr/imported/carprofen.pdf PROPN ct-10491 250 7 https://cdn.ymaws.com/www.aavpt.org/resource/resmgr/imported/carprofen.pdf https://cdn.ymaws.com/www.aavpt.org/resource/resmgr/imported/carprofen.pdf PROPN ct-10491 250 8 https://doi.org/10.1023/a:1011907920641 https://doi.org/10.1023/a:1011907920641 PROPN ct-10491 250 9 https://doi.org/10.2165/00003088-199630060-00003 https://doi.org/10.2165/00003088-199630060-00003 PROPN ct-10491 250 10 https://doi.org/10.2460/ajvr.2002.63.1622 https://doi.org/10.2460/ajvr.2002.63.1622 PROPN ct-10491 250 11 https://doi.org/10.1002/ame2.12043 https://doi.org/10.1002/ame2.12043 PRON ct-10491 250 12 https://doi.org/10.1517/17425251003677755 https://doi.org/10.1517/17425251003677755 PRON ct-10491 251 1 https://doi.org/10.1111/j.1532-950x.1998.tb00533.x https://doi.org/10.1111/j.1532-950x.1998.tb00533.x VERB ct-10491 251 2 https://doi.org/10.1111/j.1532-950x.1998.tb00533.x https://doi.org/10.1111/j.1532-950x.1998.tb00533.x X ct-10491 252 1 https://doi.org/10.1016/s0034-5288(18)31075-0 https://doi.org/10.1016/s0034-5288(18)31075-0 VERB ct-10491 252 2 https://doi.org/10.1177/1091581810367949 https://doi.org/10.1177/1091581810367949 X