id sid tid token lemma pos ct-9697 1 1 cervix cervix NOUN ct-9697 1 2 and and CCONJ ct-9697 1 3 myometrium myometrium NOUN ct-9697 1 4 : : PUNCT ct-9697 1 5 role role NOUN ct-9697 1 6 in in ADP ct-9697 1 7 preterm preterm NOUN ct-9697 1 8 and and CCONJ ct-9697 1 9 normal normal ADJ ct-9697 1 10 term term NOUN ct-9697 1 11 birth birth NOUN ct-9697 1 12 in in ADP ct-9697 1 13 mare mare NOUN ct-9697 1 14 cervix cervix NOUN ct-9697 1 15 and and CCONJ ct-9697 1 16 myometrium myometrium NOUN ct-9697 1 17 : : PUNCT ct-9697 1 18 role role NOUN ct-9697 1 19 in in ADP ct-9697 1 20 preterm preterm NOUN ct-9697 1 21 and and CCONJ ct-9697 1 22 normal normal ADJ ct-9697 1 23 term term NOUN ct-9697 1 24 birth birth NOUN ct-9697 1 25 in in ADP ct-9697 1 26 mare mare PROPN ct-9697 1 27 hossam hossam PROPN ct-9697 1 28 el el PROPN ct-9697 1 29 - - PUNCT ct-9697 1 30 sheikh sheikh PROPN ct-9697 1 31 ali ali PROPN ct-9697 1 32 and and CCONJ ct-9697 1 33 barry barry PROPN ct-9697 1 34 ball ball PROPN ct-9697 1 35 gluck gluck PROPN ct-9697 1 36 equine equine PROPN ct-9697 1 37 research research NOUN ct-9697 1 38 center center NOUN ct-9697 1 39 , , PUNCT ct-9697 1 40 department department NOUN ct-9697 1 41 of of ADP ct-9697 1 42 veterinary veterinary ADJ ct-9697 1 43 science science PROPN ct-9697 1 44 university university PROPN ct-9697 1 45 of of ADP ct-9697 1 46 kentucky kentucky PROPN ct-9697 1 47 , , PUNCT ct-9697 1 48 lexington lexington PROPN ct-9697 1 49 , , PUNCT ct-9697 1 50 ky ky PROPN ct-9697 1 51 abstract abstract ADJ ct-9697 1 52 myometrial myometrial ADJ ct-9697 1 53 activation activation NOUN ct-9697 1 54 and and CCONJ ct-9697 1 55 cervical cervical ADJ ct-9697 1 56 remodeling remodeling NOUN ct-9697 1 57 during during ADP ct-9697 1 58 term term NOUN ct-9697 1 59 and and CCONJ ct-9697 1 60 preterm preterm ADJ ct-9697 1 61 labor labor NOUN ct-9697 1 62 involve involve VERB ct-9697 1 63 complex complex ADJ ct-9697 1 64 molecular molecular ADJ ct-9697 1 65 mechanisms mechanism NOUN ct-9697 1 66 . . PUNCT ct-9697 2 1 progress progress NOUN ct-9697 2 2 in in ADP ct-9697 2 3 elucidating elucidate VERB ct-9697 2 4 these these DET ct-9697 2 5 mechanisms mechanism NOUN ct-9697 2 6 has have AUX ct-9697 2 7 been be AUX ct-9697 2 8 slow slow ADJ ct-9697 2 9 and and CCONJ ct-9697 2 10 based base VERB ct-9697 2 11 on on ADP ct-9697 2 12 classical classical ADJ ct-9697 2 13 molecular molecular ADJ ct-9697 2 14 techniques technique NOUN ct-9697 2 15 such such ADJ ct-9697 2 16 as as ADP ct-9697 2 17 realtime realtime ADJ ct-9697 2 18 quantitative quantitative ADJ ct-9697 2 19 reverse reverse NOUN ct-9697 2 20 transcription transcription NOUN ct-9697 2 21 polymerase polymerase NOUN ct-9697 2 22 chain chain NOUN ct-9697 2 23 reaction reaction NOUN ct-9697 2 24 . . PUNCT ct-9697 3 1 recently recently ADV ct-9697 3 2 , , PUNCT ct-9697 3 3 using use VERB ct-9697 3 4 ribonucleic ribonucleic ADJ ct-9697 3 5 acid acid NOUN ct-9697 3 6 sequencing sequencing NOUN ct-9697 3 7 , , PUNCT ct-9697 3 8 we we PRON ct-9697 3 9 have have AUX ct-9697 3 10 elucidated elucidate VERB ct-9697 3 11 key key ADJ ct-9697 3 12 regulators regulator NOUN ct-9697 3 13 and and CCONJ ct-9697 3 14 molecular molecular ADJ ct-9697 3 15 mechanisms mechanism NOUN ct-9697 3 16 triggering trigger VERB ct-9697 3 17 these these DET ct-9697 3 18 events event NOUN ct-9697 3 19 . . PUNCT ct-9697 4 1 objective objective NOUN ct-9697 4 2 is be AUX ct-9697 4 3 to to PART ct-9697 4 4 summarize summarize VERB ct-9697 4 5 changes change NOUN ct-9697 4 6 in in ADP ct-9697 4 7 myometrial myometrial ADJ ct-9697 4 8 and and CCONJ ct-9697 4 9 cervical cervical ADJ ct-9697 4 10 transcriptome transcriptome NOUN ct-9697 4 11 during during ADP ct-9697 4 12 placentitis placentitis PROPN ct-9697 4 13 and and CCONJ ct-9697 4 14 normal normal ADJ ct-9697 4 15 prepartum prepartum NOUN ct-9697 4 16 period period NOUN ct-9697 4 17 in in ADP ct-9697 4 18 comparison comparison NOUN ct-9697 4 19 to to ADP ct-9697 4 20 normal normal ADJ ct-9697 4 21 pregnancy pregnancy NOUN ct-9697 4 22 . . PUNCT ct-9697 5 1 keywords keyword NOUN ct-9697 5 2 : : PUNCT ct-9697 5 3 mare mare NOUN ct-9697 5 4 , , PUNCT ct-9697 5 5 cervix cervix NOUN ct-9697 5 6 , , PUNCT ct-9697 5 7 myometrium myometrium NOUN ct-9697 5 8 , , PUNCT ct-9697 5 9 pregnancy pregnancy NOUN ct-9697 5 10 , , PUNCT ct-9697 5 11 progestins progestin NOUN ct-9697 5 12 , , PUNCT ct-9697 5 13 parturition parturition NOUN ct-9697 5 14 , , PUNCT ct-9697 5 15 placentitis placentitis PROPN ct-9697 5 16 introduction introduction NOUN ct-9697 5 17 placentitis placentitis PROPN ct-9697 5 18 induced induce VERB ct-9697 5 19 preterm preterm NOUN ct-9697 5 20 labor labor NOUN ct-9697 5 21 and and CCONJ ct-9697 5 22 term term NOUN ct-9697 5 23 labor labor NOUN ct-9697 5 24 share share VERB ct-9697 5 25 a a DET ct-9697 5 26 common common ADJ ct-9697 5 27 pathway pathway NOUN ct-9697 5 28 that that PRON ct-9697 5 29 includes include VERB ct-9697 5 30 3 3 NUM ct-9697 5 31 major major ADJ ct-9697 5 32 events event NOUN ct-9697 5 33 : : PUNCT ct-9697 5 34 myometrial myometrial ADJ ct-9697 5 35 activation activation NOUN ct-9697 5 36 , , PUNCT ct-9697 5 37 cervical cervical ADJ ct-9697 5 38 remodeling remodeling NOUN ct-9697 5 39 and and CCONJ ct-9697 5 40 chorioallantois chorioallantois NOUN ct-9697 5 41 activation activation NOUN ct-9697 5 42 ( ( PUNCT ct-9697 5 43 separation separation NOUN ct-9697 5 44 and and CCONJ ct-9697 5 45 rupture).1 rupture).1 PROPN ct-9697 5 46 - - PUNCT ct-9697 5 47 4 4 NUM ct-9697 5 48 understanding understand VERB ct-9697 5 49 molecular molecular ADJ ct-9697 5 50 mechanisms mechanism NOUN ct-9697 5 51 of of ADP ct-9697 5 52 these these DET ct-9697 5 53 3 3 NUM ct-9697 5 54 events event NOUN ct-9697 5 55 holds hold VERB ct-9697 5 56 potential potential NOUN ct-9697 5 57 for for ADP ct-9697 5 58 development development NOUN ct-9697 5 59 of of ADP ct-9697 5 60 new new ADJ ct-9697 5 61 diagnostic diagnostic ADJ ct-9697 5 62 tools tool NOUN ct-9697 5 63 and and CCONJ ct-9697 5 64 therapies therapy NOUN ct-9697 5 65 to to PART ct-9697 5 66 forestall forestall VERB ct-9697 5 67 placentitis placentitis PROPN ct-9697 5 68 induced induce VERB ct-9697 5 69 preterm preterm ADJ ct-9697 5 70 labor labor NOUN ct-9697 5 71 . . PUNCT ct-9697 6 1 recently recently ADV ct-9697 6 2 , , PUNCT ct-9697 6 3 using use VERB ct-9697 6 4 a a DET ct-9697 6 5 transcriptomic transcriptomic ADJ ct-9697 6 6 approach approach NOUN ct-9697 6 7 ( ( PUNCT ct-9697 6 8 i.e. i.e. X ct-9697 6 9 ribonucleic ribonucleic ADJ ct-9697 6 10 acid acid NOUN ct-9697 6 11 sequencing sequencing NOUN ct-9697 6 12 ) ) PUNCT ct-9697 6 13 , , PUNCT ct-9697 6 14 we we PRON ct-9697 6 15 elucidated elucidate VERB ct-9697 6 16 key key ADJ ct-9697 6 17 regulators regulator NOUN ct-9697 6 18 and and CCONJ ct-9697 6 19 molecular molecular ADJ ct-9697 6 20 mechanisms mechanism NOUN ct-9697 6 21 , , PUNCT ct-9697 6 22 triggering trigger VERB ct-9697 6 23 these these DET ct-9697 6 24 events event NOUN ct-9697 6 25 in in ADP ct-9697 6 26 an an DET ct-9697 6 27 experimental experimental ADJ ct-9697 6 28 model model NOUN ct-9697 6 29 of of ADP ct-9697 6 30 acute acute NOUN ct-9697 6 31 ascending ascend VERB ct-9697 6 32 placentitis placentitis PROPN ct-9697 6 33 . . PUNCT ct-9697 7 1 objective objective NOUN ct-9697 7 2 is be AUX ct-9697 7 3 to to PART ct-9697 7 4 summarize summarize VERB ct-9697 7 5 our our PRON ct-9697 7 6 recent recent ADJ ct-9697 7 7 findings finding NOUN ct-9697 7 8 , , PUNCT ct-9697 7 9 with with ADP ct-9697 7 10 a a DET ct-9697 7 11 focus focus NOUN ct-9697 7 12 on on ADP ct-9697 7 13 mechanisms mechanism NOUN ct-9697 7 14 underlying underlie VERB ct-9697 7 15 myometrial myometrial ADJ ct-9697 7 16 activation activation NOUN ct-9697 7 17 and and CCONJ ct-9697 7 18 cervical cervical ADJ ct-9697 7 19 remodeling remodeling NOUN ct-9697 7 20 during during ADP ct-9697 7 21 equine equine NOUN ct-9697 7 22 placentitis placentitis PROPN ct-9697 7 23 and and CCONJ ct-9697 7 24 normal normal ADJ ct-9697 7 25 prepartum prepartum NOUN ct-9697 7 26 period period NOUN ct-9697 7 27 in in ADP ct-9697 7 28 comparison comparison NOUN ct-9697 7 29 to to ADP ct-9697 7 30 normal normal ADJ ct-9697 7 31 pregnancy pregnancy NOUN ct-9697 7 32 . . PUNCT ct-9697 8 1 myometrial myometrial ADJ ct-9697 8 2 activation activation NOUN ct-9697 8 3 key key ADJ ct-9697 8 4 event event NOUN ct-9697 8 5 in in ADP ct-9697 8 6 placentitis placentitis PROPN ct-9697 8 7 induced induce VERB ct-9697 8 8 preterm preterm NOUN ct-9697 8 9 labor labor NOUN ct-9697 8 10 and and CCONJ ct-9697 8 11 term term NOUN ct-9697 8 12 labor labor NOUN ct-9697 8 13 is be AUX ct-9697 8 14 myometrial myometrial ADJ ct-9697 8 15 activation activation NOUN ct-9697 8 16 with with ADP ct-9697 8 17 subsequent subsequent ADJ ct-9697 8 18 initiation initiation NOUN ct-9697 8 19 of of ADP ct-9697 8 20 labor.1,5 labor.1,5 PROPN ct-9697 8 21 myometrial myometrial ADJ ct-9697 8 22 activation activation NOUN ct-9697 8 23 involves involve VERB ct-9697 8 24 complex complex ADJ ct-9697 8 25 myriad myriad NOUN ct-9697 8 26 of of ADP ct-9697 8 27 coordinated coordinate VERB ct-9697 8 28 changes change NOUN ct-9697 8 29 involving involve VERB ct-9697 8 30 immune immune ADJ ct-9697 8 31 and and CCONJ ct-9697 8 32 hormonal hormonal ADJ ct-9697 8 33 factors factor NOUN ct-9697 8 34 , , PUNCT ct-9697 8 35 upregulation upregulation NOUN ct-9697 8 36 of of ADP ct-9697 8 37 several several ADJ ct-9697 8 38 contraction contraction NOUN ct-9697 8 39 - - PUNCT ct-9697 8 40 associated associate VERB ct-9697 8 41 proteins protein NOUN ct-9697 8 42 ( ( PUNCT ct-9697 8 43 caps cap NOUN ct-9697 8 44 ) ) PUNCT ct-9697 8 45 , , PUNCT ct-9697 8 46 and and CCONJ ct-9697 8 47 arrangement arrangement NOUN ct-9697 8 48 of of ADP ct-9697 8 49 cytoskeletal cytoskeletal ADJ ct-9697 8 50 machinery machinery NOUN ct-9697 8 51 that that PRON ct-9697 8 52 provides provide VERB ct-9697 8 53 uterus uterus NOUN ct-9697 8 54 capacity capacity NOUN ct-9697 8 55 to to PART ct-9697 8 56 generate generate VERB ct-9697 8 57 force force NOUN ct-9697 8 58 and and CCONJ ct-9697 8 59 contract1,5 contract1,5 PROPN ct-9697 8 60 mechanisms mechanism VERB ct-9697 8 61 underlying underlie VERB ct-9697 8 62 myometrial myometrial ADJ ct-9697 8 63 activation activation NOUN ct-9697 8 64 during during ADP ct-9697 8 65 equine equine NOUN ct-9697 8 66 placentitis placentitis PROPN ct-9697 8 67 and and CCONJ ct-9697 8 68 normal normal ADJ ct-9697 8 69 prepartum prepartum NOUN ct-9697 8 70 period period NOUN ct-9697 8 71 are be AUX ct-9697 8 72 summarized summarize VERB ct-9697 8 73 ( ( PUNCT ct-9697 8 74 figures figure NOUN ct-9697 8 75 1 1 NUM ct-9697 8 76 and and CCONJ ct-9697 8 77 2 2 NUM ct-9697 8 78 ) ) PUNCT ct-9697 8 79 . . PUNCT ct-9697 9 1 progestins progestin NOUN ct-9697 9 2 and and CCONJ ct-9697 9 3 progesterone progesterone NOUN ct-9697 9 4 receptor receptor NOUN ct-9697 9 5 signaling signal VERB ct-9697 9 6 ( ( PUNCT ct-9697 9 7 ligand ligand ADJ ct-9697 9 8 receptor receptor NOUN ct-9697 9 9 signaling signal VERB ct-9697 9 10 ) ) PUNCT ct-9697 9 11 in in ADP ct-9697 9 12 mammals mammal NOUN ct-9697 9 13 studied,6 studied,6 NOUN ct-9697 9 14 - - SYM ct-9697 9 15 8 8 NUM ct-9697 9 16 progestins progestin NOUN ct-9697 9 17 , , PUNCT ct-9697 9 18 acting act VERB ct-9697 9 19 through through ADP ct-9697 9 20 its its PRON ct-9697 9 21 nuclear nuclear ADJ ct-9697 9 22 receptor receptor NOUN ct-9697 9 23 ( ( PUNCT ct-9697 9 24 pr pr NOUN ct-9697 9 25 , , PUNCT ct-9697 9 26 also also ADV ct-9697 9 27 known know VERB ct-9697 9 28 as as ADP ct-9697 9 29 pgr pgr PROPN ct-9697 9 30 ) ) PUNCT ct-9697 9 31 , , PUNCT ct-9697 9 32 plays play VERB ct-9697 9 33 a a DET ct-9697 9 34 central central ADJ ct-9697 9 35 role role NOUN ct-9697 9 36 in in ADP ct-9697 9 37 maintaining maintain VERB ct-9697 9 38 myometrial myometrial ADJ ct-9697 9 39 quiescence quiescence NOUN ct-9697 9 40 during during ADP ct-9697 9 41 pregnancy pregnancy NOUN ct-9697 9 42 through through ADP ct-9697 9 43 blockage blockage NOUN ct-9697 9 44 of of ADP ct-9697 9 45 inflammatory inflammatory ADJ ct-9697 9 46 cascade cascade NOUN ct-9697 9 47 and and CCONJ ct-9697 9 48 suppression suppression NOUN ct-9697 9 49 of of ADP ct-9697 9 50 caps cap NOUN ct-9697 9 51 . . PUNCT ct-9697 10 1 recently recently ADV ct-9697 10 2 , , PUNCT ct-9697 10 3 we we PRON ct-9697 10 4 reported report VERB ct-9697 10 5 that that SCONJ ct-9697 10 6 myometrial myometrial ADJ ct-9697 10 7 tissue tissue NOUN ct-9697 10 8 concentrations concentration NOUN ct-9697 10 9 of of ADP ct-9697 10 10 5α 5α ADJ ct-9697 10 11 dihydroprogesterone dihydroprogesterone NOUN ct-9697 10 12 ( ( PUNCT ct-9697 10 13 5α 5α PROPN ct-9697 10 14 dhp dhp PROPN ct-9697 10 15 , , PUNCT ct-9697 10 16 also also ADV ct-9697 10 17 known know VERB ct-9697 10 18 as as ADP ct-9697 10 19 dhp dhp PROPN ct-9697 10 20 ) ) PUNCT ct-9697 10 21 , , PUNCT ct-9697 10 22 allopregnanolone allopregnanolone NOUN ct-9697 10 23 ( ( PUNCT ct-9697 10 24 3α 3α NUM ct-9697 10 25 dhp dhp PROPN ct-9697 10 26 ) ) PUNCT ct-9697 10 27 and and CCONJ ct-9697 10 28 20α 20α NOUN ct-9697 10 29 hydroxy hydroxy VERB ct-9697 10 30 5α 5α PROPN ct-9697 10 31 dihydroprogesterone dihydroprogesterone NOUN ct-9697 10 32 ( ( PUNCT ct-9697 10 33 20α 20α X ct-9697 10 34 dhp dhp PROPN ct-9697 10 35 ) ) PUNCT ct-9697 10 36 were be AUX ct-9697 10 37 lower low ADJ ct-9697 10 38 ( ( PUNCT ct-9697 10 39 progestin progestin NOUN ct-9697 10 40 withdrawal withdrawal PROPN ct-9697 10 41 ) ) PUNCT ct-9697 10 42 in in ADP ct-9697 10 43 mares mare NOUN ct-9697 10 44 with with ADP ct-9697 10 45 experimentally experimentally ADV ct-9697 10 46 induced induce VERB ct-9697 10 47 acute acute ADJ ct-9697 10 48 placentitis placentitis PROPN ct-9697 10 49 compared compare VERB ct-9697 10 50 to to ADP ct-9697 10 51 ageand ageand NOUN ct-9697 10 52 pregnancy pregnancy NOUN ct-9697 10 53 - - PUNCT ct-9697 10 54 matched match VERB ct-9697 10 55 controls.1 controls.1 NOUN ct-9697 10 56 this this DET ct-9697 10 57 local local ADJ ct-9697 10 58 reduction reduction NOUN ct-9697 10 59 in in ADP ct-9697 10 60 5α 5α PROPN ct-9697 10 61 dhp dhp PROPN ct-9697 10 62 and and CCONJ ct-9697 10 63 its its PRON ct-9697 10 64 downstream downstream ADJ ct-9697 10 65 metabolites metabolite NOUN ct-9697 10 66 is be AUX ct-9697 10 67 attributed attribute VERB ct-9697 10 68 to to ADP ct-9697 10 69 a a DET ct-9697 10 70 decline decline NOUN ct-9697 10 71 in in ADP ct-9697 10 72 enzymes enzyme NOUN ct-9697 10 73 responsible responsible ADJ ct-9697 10 74 for for ADP ct-9697 10 75 synthesis synthesis NOUN ct-9697 10 76 of of ADP ct-9697 10 77 these these DET ct-9697 10 78 progestins progestin NOUN ct-9697 10 79 , , PUNCT ct-9697 10 80 such such ADJ ct-9697 10 81 as as ADP ct-9697 10 82 5α 5α NUM ct-9697 10 83 reductase reductase NOUN ct-9697 10 84 type type NOUN ct-9697 10 85 1 1 NUM ct-9697 10 86 ( ( PUNCT ct-9697 10 87 5α 5α ADJ ct-9697 10 88 r1 r1 PROPN ct-9697 10 89 also also ADV ct-9697 10 90 known know VERB ct-9697 10 91 as as ADP ct-9697 10 92 srd5a1 srd5a1 NOUN ct-9697 10 93 ) ) PUNCT ct-9697 10 94 and and CCONJ ct-9697 10 95 aldo aldo PROPN ct-9697 10 96 - - PUNCT ct-9697 10 97 keto keto NOUN ct-9697 10 98 reductase reductase NOUN ct-9697 10 99 family family NOUN ct-9697 10 100 1 1 NUM ct-9697 10 101 member member NOUN ct-9697 10 102 c23 c23 PROPN ct-9697 10 103 ( ( PUNCT ct-9697 10 104 akr1c23 akr1c23 PROPN ct-9697 10 105 , , PUNCT ct-9697 10 106 also also ADV ct-9697 10 107 known know VERB ct-9697 10 108 as as ADP ct-9697 10 109 akr1c1).1 akr1c1).1 ADV ct-9697 10 110 moreover moreover ADV ct-9697 10 111 , , PUNCT ct-9697 10 112 expression expression NOUN ct-9697 10 113 of of ADP ct-9697 10 114 nuclear nuclear ADJ ct-9697 10 115 pr pr NOUN ct-9697 10 116 is be AUX ct-9697 10 117 downregulated downregulate VERB ct-9697 10 118 ( ( PUNCT ct-9697 10 119 functional functional ADJ ct-9697 10 120 progestin progestin NOUN ct-9697 10 121 withdrawal withdrawal PROPN ct-9697 10 122 ) ) PUNCT ct-9697 10 123 in in ADP ct-9697 10 124 equine equine NOUN ct-9697 10 125 myometrium myometrium NOUN ct-9697 10 126 during during ADP ct-9697 10 127 placentitis placentitis PROPN ct-9697 10 128 . . PUNCT ct-9697 11 1 a a DET ct-9697 11 2 closer close ADJ ct-9697 11 3 look look NOUN ct-9697 11 4 at at ADP ct-9697 11 5 pr pr NOUN ct-9697 11 6 - - PUNCT ct-9697 11 7 isoforms isoform NOUN ct-9697 11 8 proteins protein NOUN ct-9697 11 9 ( ( PUNCT ct-9697 11 10 i.e. i.e. X ct-9697 11 11 pr pr NOUN ct-9697 11 12 - - PUNCT ct-9697 11 13 a a NOUN ct-9697 11 14 and and CCONJ ct-9697 11 15 pr pr NOUN ct-9697 11 16 - - PUNCT ct-9697 11 17 b b NOUN ct-9697 11 18 ) ) PUNCT ct-9697 11 19 revealed reveal VERB ct-9697 11 20 a a DET ct-9697 11 21 decrease decrease NOUN ct-9697 11 22 in in ADP ct-9697 11 23 pr pr NOUN ct-9697 11 24 - - PUNCT ct-9697 11 25 b b NOUN ct-9697 11 26 to to PART ct-9697 11 27 pr pr NOUN ct-9697 11 28 - - PUNCT ct-9697 11 29 a a DET ct-9697 11 30 ratio.1 ratio.1 NOUN ct-9697 11 31 it it PRON ct-9697 11 32 is be AUX ct-9697 11 33 worth worth ADJ ct-9697 11 34 noting note VERB ct-9697 11 35 that that SCONJ ct-9697 11 36 in in ADP ct-9697 11 37 primates primate NOUN ct-9697 11 38 , , PUNCT ct-9697 11 39 progesterone progesterone NOUN ct-9697 11 40 ( ( PUNCT ct-9697 11 41 p4 p4 ADJ ct-9697 11 42 ) ) PUNCT ct-9697 11 43 promotes promote VERB ct-9697 11 44 myometrial myometrial ADJ ct-9697 11 45 quiescence quiescence NOUN ct-9697 11 46 through through ADP ct-9697 11 47 pr pr NOUN ct-9697 11 48 - - PUNCT ct-9697 11 49 b b NOUN ct-9697 11 50 - - PUNCT ct-9697 11 51 mediated mediate VERB ct-9697 11 52 antiinflammatory antiinflammatory NOUN ct-9697 11 53 actions.9 actions.9 PROPN ct-9697 11 54 at at ADP ct-9697 11 55 labor labor NOUN ct-9697 11 56 , , PUNCT ct-9697 11 57 pr pr NOUN ct-9697 11 58 - - PUNCT ct-9697 11 59 a a PRON ct-9697 11 60 becomes become VERB ct-9697 11 61 more more ADV ct-9697 11 62 predominant predominant ADJ ct-9697 11 63 and and CCONJ ct-9697 11 64 inhibits inhibit VERB ct-9697 11 65 antiinflammatory antiinflammatory NOUN ct-9697 11 66 actions action NOUN ct-9697 11 67 of of ADP ct-9697 11 68 pr pr NOUN ct-9697 11 69 - - PUNCT ct-9697 11 70 b b NOUN ct-9697 11 71 and and CCONJ ct-9697 11 72 stimulates stimulate VERB ct-9697 11 73 proinflammatory proinflammatory ADJ ct-9697 11 74 gene gene NOUN ct-9697 11 75 expression.9 expression.9 NOUN ct-9697 11 76 downregulation downregulation NOUN ct-9697 11 77 in in ADP ct-9697 11 78 progestin progestin NOUN ct-9697 11 79 - - PUNCT ct-9697 11 80 pr pr NOUN ct-9697 11 81 signaling signaling NOUN ct-9697 11 82 is be AUX ct-9697 11 83 in in ADP ct-9697 11 84 turn turn NOUN ct-9697 11 85 associated associate VERB ct-9697 11 86 with with ADP ct-9697 11 87 activation activation NOUN ct-9697 11 88 of of ADP ct-9697 11 89 nf nf ADJ ct-9697 11 90 - - PUNCT ct-9697 11 91 κb κb NOUN ct-9697 11 92 pathway pathway NOUN ct-9697 11 93 and and CCONJ ct-9697 11 94 upregulation upregulation NOUN ct-9697 11 95 of of ADP ct-9697 11 96 proinflammatory proinflammatory ADJ ct-9697 11 97 cytokines cytokine NOUN ct-9697 11 98 ( ( PUNCT ct-9697 11 99 e.g. e.g. ADV ct-9697 11 100 il1β il1β PROPN ct-9697 11 101 ) ) PUNCT ct-9697 11 102 , , PUNCT ct-9697 11 103 as as ADV ct-9697 11 104 well well ADV ct-9697 11 105 as as ADP ct-9697 11 106 upregulation upregulation NOUN ct-9697 11 107 clinical clinical ADJ ct-9697 11 108 theriogenology theriogenology NOUN ct-9697 12 1 • • NOUN ct-9697 12 2 volume volume NOUN ct-9697 12 3 12 12 NUM ct-9697 12 4 number number NOUN ct-9697 12 5 3 3 NUM ct-9697 12 6 • • NOUN ct-9697 12 7 september september PROPN ct-9697 12 8 2020340 2020340 NUM ct-9697 12 9 of of ADP ct-9697 12 10 transcripts transcript NOUN ct-9697 12 11 coding code VERB ct-9697 12 12 for for ADP ct-9697 12 13 caps cap NOUN ct-9697 12 14 ( ( PUNCT ct-9697 12 15 e.g. e.g. ADV ct-9697 12 16 ptgs2 ptgs2 PROPN ct-9697 12 17 and and CCONJ ct-9697 12 18 gja4).1 gja4).1 PROPN ct-9697 12 19 together together ADV ct-9697 12 20 , , PUNCT ct-9697 12 21 these these DET ct-9697 12 22 findings finding NOUN ct-9697 12 23 suggest suggest VERB ct-9697 12 24 that that SCONJ ct-9697 12 25 placentitis placentitis PROPN ct-9697 12 26 induces induce VERB ct-9697 12 27 localized localized ADJ ct-9697 12 28 progestin progestin NOUN ct-9697 12 29 withdrawal withdrawal NOUN ct-9697 12 30 and and CCONJ ct-9697 12 31 progestin progestin ADJ ct-9697 12 32 functional functional ADJ ct-9697 12 33 withdrawal withdrawal NOUN ct-9697 12 34 in in ADP ct-9697 12 35 myometrium myometrium NOUN ct-9697 12 36 that that PRON ct-9697 12 37 lead lead VERB ct-9697 12 38 to to ADP ct-9697 12 39 myometrial myometrial ADJ ct-9697 12 40 activation activation NOUN ct-9697 12 41 through through ADP ct-9697 12 42 activation activation NOUN ct-9697 12 43 of of ADP ct-9697 12 44 inflammatory inflammatory ADJ ct-9697 12 45 cascade cascade NOUN ct-9697 12 46 and and CCONJ ct-9697 12 47 upregulation upregulation NOUN ct-9697 12 48 of of ADP ct-9697 12 49 caps cap NOUN ct-9697 12 50 . . PUNCT ct-9697 13 1 in in ADP ct-9697 13 2 prepartum prepartum PROPN ct-9697 13 3 myometrial myometrial ADJ ct-9697 13 4 transcriptome transcriptome NOUN ct-9697 13 5 , , PUNCT ct-9697 13 6 although although SCONJ ct-9697 13 7 we we PRON ct-9697 13 8 did do AUX ct-9697 13 9 not not PART ct-9697 13 10 identify identify VERB ct-9697 13 11 any any DET ct-9697 13 12 significant significant ADJ ct-9697 13 13 changes change NOUN ct-9697 13 14 in in ADP ct-9697 13 15 geneses genesis NOUN ct-9697 13 16 coding code VERB ct-9697 13 17 for for ADP ct-9697 13 18 srd5a1 srd5a1 NOUN ct-9697 13 19 , , PUNCT ct-9697 13 20 akr1c1 akr1c1 NOUN ct-9697 13 21 and and CCONJ ct-9697 13 22 pr pr NOUN ct-9697 13 23 , , PUNCT ct-9697 13 24 we we PRON ct-9697 13 25 identified identify VERB ct-9697 13 26 upregulation upregulation NOUN ct-9697 13 27 of of ADP ct-9697 13 28 aldehyde aldehyde NOUN ct-9697 13 29 dehydrogenases dehydrogenase NOUN ct-9697 13 30 ( ( PUNCT ct-9697 13 31 aldh1a1 aldh1a1 ADJ ct-9697 13 32 , , PUNCT ct-9697 13 33 aldh1a2 aldh1a2 ADJ ct-9697 13 34 , , PUNCT ct-9697 13 35 and and CCONJ ct-9697 13 36 aldh1a3 aldh1a3 NUM ct-9697 13 37 ) ) PUNCT ct-9697 13 38 . . PUNCT ct-9697 14 1 it it PRON ct-9697 14 2 is be AUX ct-9697 14 3 worth worth ADJ ct-9697 14 4 noting note VERB ct-9697 14 5 that that SCONJ ct-9697 14 6 aldh1 aldh1 PROPN ct-9697 14 7 family family NOUN ct-9697 14 8 is be AUX ct-9697 14 9 involved involve VERB ct-9697 14 10 in in ADP ct-9697 14 11 conversion conversion NOUN ct-9697 14 12 of of ADP ct-9697 14 13 retinaldehyde retinaldehyde NOUN ct-9697 14 14 to to ADP ct-9697 14 15 retinoic retinoic PROPN ct-9697 14 16 acid acid PROPN ct-9697 14 17 , , PUNCT ct-9697 14 18 which which PRON ct-9697 14 19 in in ADP ct-9697 14 20 turn turn NOUN ct-9697 14 21 decreases decrease VERB ct-9697 14 22 pr pr NOUN ct-9697 14 23 transcription.10 transcription.10 NOUN ct-9697 14 24 therefore therefore ADV ct-9697 14 25 , , PUNCT ct-9697 14 26 upregulation upregulation NOUN ct-9697 14 27 of of ADP ct-9697 14 28 aldhs aldhs PROPN ct-9697 14 29 during during ADP ct-9697 14 30 prepartum prepartum NOUN ct-9697 14 31 period period NOUN ct-9697 14 32 might might AUX ct-9697 14 33 contribute contribute VERB ct-9697 14 34 to to ADP ct-9697 14 35 myometrial myometrial ADJ ct-9697 14 36 preparation preparation NOUN ct-9697 14 37 for for ADP ct-9697 14 38 labor labor NOUN ct-9697 14 39 . . PUNCT ct-9697 15 1 figure figure VERB ct-9697 15 2 1 1 NUM ct-9697 15 3 . . PUNCT ct-9697 15 4 progestin progestin NOUN ct-9697 15 5 - - PUNCT ct-9697 15 6 progesterone progesterone NOUN ct-9697 15 7 receptor receptor NOUN ct-9697 15 8 signaling signal VERB ct-9697 15 9 during during ADP ct-9697 15 10 equine equine NOUN ct-9697 15 11 placentitis placentitis PROPN ct-9697 15 12 . . PUNCT ct-9697 16 1 a a DET ct-9697 16 2 ) ) PUNCT ct-9697 16 3 pr pr NOUN ct-9697 16 4 - - PUNCT ct-9697 16 5 b/ b/ NOUN ct-9697 16 6 pr pr NOUN ct-9697 16 7 - - PUNCT ct-9697 16 8 a a DET ct-9697 16 9 ratio ratio NOUN ct-9697 16 10 in in ADP ct-9697 16 11 myometrium myometrium NOUN ct-9697 16 12 during during ADP ct-9697 16 13 pregnancy pregnancy NOUN ct-9697 16 14 and and CCONJ ct-9697 16 15 placentitis placentitis PROPN ct-9697 16 16 . . PUNCT ct-9697 17 1 b b X ct-9697 17 2 ) ) PUNCT ct-9697 17 3 molecular molecular ADJ ct-9697 17 4 mechanisms mechanism NOUN ct-9697 17 5 underlying underlie VERB ct-9697 17 6 progestin progestin NOUN ct-9697 17 7 withdrawal withdrawal NOUN ct-9697 17 8 and and CCONJ ct-9697 17 9 progestin progestin ADJ ct-9697 17 10 functional functional ADJ ct-9697 17 11 withdrawal withdrawal NOUN ct-9697 17 12 in in ADP ct-9697 17 13 equine equine NOUN ct-9697 17 14 myometrium myometrium NOUN ct-9697 17 15 during during ADP ct-9697 17 16 placentitis placentitis PROPN ct-9697 17 17 . . PUNCT ct-9697 18 1 activation activation NOUN ct-9697 18 2 of of ADP ct-9697 18 3 inflammatory inflammatory ADJ ct-9697 18 4 cascade cascade NOUN ct-9697 18 5 in in ADP ct-9697 18 6 myometrium myometrium NOUN ct-9697 18 7 during during ADP ct-9697 18 8 inflammatory inflammatory ADJ ct-9697 18 9 reaction reaction NOUN ct-9697 18 10 in in ADP ct-9697 18 11 pathogenic pathogenic ADJ ct-9697 18 12 infection infection NOUN ct-9697 18 13 , , PUNCT ct-9697 18 14 inflammatory inflammatory ADJ ct-9697 18 15 cascade cascade NOUN ct-9697 18 16 is be AUX ct-9697 18 17 initiated initiate VERB ct-9697 18 18 by by ADP ct-9697 18 19 immune immune ADJ ct-9697 18 20 recognition recognition NOUN ct-9697 18 21 of of ADP ct-9697 18 22 pathogen pathogen NOUN ct-9697 18 23 mediated mediate VERB ct-9697 18 24 through through ADP ct-9697 18 25 toll toll NOUN ct-9697 18 26 - - PUNCT ct-9697 18 27 like like ADJ ct-9697 18 28 receptors receptor NOUN ct-9697 18 29 ( ( PUNCT ct-9697 18 30 tlrs tlrs NOUN ct-9697 18 31 ) ) PUNCT ct-9697 18 32 , , PUNCT ct-9697 18 33 which which PRON ct-9697 18 34 are be AUX ct-9697 18 35 primary primary ADJ ct-9697 18 36 and and CCONJ ct-9697 18 37 earliest early ADJ ct-9697 18 38 detection detection NOUN ct-9697 18 39 mechanisms mechanism NOUN ct-9697 18 40 for for ADP ct-9697 18 41 pathogens.11 pathogens.11 NOUN ct-9697 18 42 among among ADP ct-9697 18 43 known know VERB ct-9697 18 44 tlrs tlrs NOUN ct-9697 18 45 , , PUNCT ct-9697 18 46 tlr2 tlr2 PROPN ct-9697 18 47 and and CCONJ ct-9697 18 48 tlr4 tlr4 NOUN ct-9697 18 49 are be AUX ct-9697 18 50 responsible responsible ADJ ct-9697 18 51 for for ADP ct-9697 18 52 recognition recognition NOUN ct-9697 18 53 of of ADP ct-9697 18 54 gram gram PROPN ct-9697 18 55 positive positive ADJ ct-9697 18 56 and and CCONJ ct-9697 18 57 negative negative ADJ ct-9697 18 58 bacteria bacteria NOUN ct-9697 18 59 , , PUNCT ct-9697 18 60 respectively.12 respectively.12 NOUN ct-9697 18 61 recently recently ADV ct-9697 18 62 , , PUNCT ct-9697 18 63 we we PRON ct-9697 18 64 identified identify VERB ct-9697 18 65 streptococcus streptococcus NOUN ct-9697 18 66 induced induce VERB ct-9697 18 67 placentitis placentitis PROPN ct-9697 18 68 to to PART ct-9697 18 69 be be AUX ct-9697 18 70 associated associate VERB ct-9697 18 71 with with ADP ct-9697 18 72 upregulation upregulation NOUN ct-9697 18 73 of of ADP ct-9697 18 74 tlr2 tlr2 PROPN ct-9697 18 75 in in ADP ct-9697 18 76 myometrial myometrial ADJ ct-9697 18 77 samples sample NOUN ct-9697 18 78 retrieved retrieve VERB ct-9697 18 79 from from ADP ct-9697 18 80 placentitis placentitis PROPN ct-9697 18 81 group group NOUN ct-9697 18 82 in in ADP ct-9697 18 83 comparison comparison NOUN ct-9697 18 84 to to PART ct-9697 18 85 control control VERB ct-9697 18 86 group.2 group.2 PROPN ct-9697 18 87 moreover moreover ADV ct-9697 18 88 , , PUNCT ct-9697 18 89 this this DET ct-9697 18 90 upregulation upregulation NOUN ct-9697 18 91 is be AUX ct-9697 18 92 associated associate VERB ct-9697 18 93 with with ADP ct-9697 18 94 upregulation upregulation NOUN ct-9697 18 95 of of ADP ct-9697 18 96 a a DET ct-9697 18 97 wide wide ADJ ct-9697 18 98 array array NOUN ct-9697 18 99 of of ADP ct-9697 18 100 tlr2 tlr2 NOUN ct-9697 18 101 - - PUNCT ct-9697 18 102 dependent dependent ADJ ct-9697 18 103 downstream downstream ADJ ct-9697 18 104 molecules molecule NOUN ct-9697 18 105 in in ADP ct-9697 18 106 inflammatory inflammatory ADJ ct-9697 18 107 cascade.2 cascade.2 PROPN ct-9697 18 108 these these DET ct-9697 18 109 findings finding NOUN ct-9697 18 110 highlight highlight VERB ct-9697 18 111 central central ADJ ct-9697 18 112 role role NOUN ct-9697 18 113 of of ADP ct-9697 18 114 tlr2 tlr2 NOUN ct-9697 18 115 in in ADP ct-9697 18 116 triggering trigger VERB ct-9697 18 117 inflammatory inflammatory ADJ ct-9697 18 118 signals signal NOUN ct-9697 18 119 in in ADP ct-9697 18 120 myometrium myometrium NOUN ct-9697 18 121 during during ADP ct-9697 18 122 streptococcus streptococcus NOUN ct-9697 18 123 induced induce VERB ct-9697 18 124 placentitis placentitis PROPN ct-9697 18 125 . . PUNCT ct-9697 19 1 therefore therefore ADV ct-9697 19 2 , , PUNCT ct-9697 19 3 targeting target VERB ct-9697 19 4 tlr2 tlr2 NOUN ct-9697 19 5 through through ADP ct-9697 19 6 therapeutic therapeutic ADJ ct-9697 19 7 inhibition inhibition NOUN ct-9697 19 8 ( ( PUNCT ct-9697 19 9 antagonism antagonism NOUN ct-9697 19 10 ) ) PUNCT ct-9697 19 11 might might AUX ct-9697 19 12 be be AUX ct-9697 19 13 beneficial beneficial ADJ ct-9697 19 14 for for ADP ct-9697 19 15 prevention prevention NOUN ct-9697 19 16 and/or and/or CCONJ ct-9697 19 17 treatment treatment NOUN ct-9697 19 18 of of ADP ct-9697 19 19 streptococcus streptococcus NOUN ct-9697 19 20 induced induce VERB ct-9697 19 21 placentitis placentitis PROPN ct-9697 19 22 . . PUNCT ct-9697 20 1 this this DET ct-9697 20 2 notion notion NOUN ct-9697 20 3 is be AUX ct-9697 20 4 supported support VERB ct-9697 20 5 by by ADP ct-9697 20 6 reports report NOUN ct-9697 20 7 in in ADP ct-9697 20 8 primates primate NOUN ct-9697 20 9 that that SCONJ ct-9697 20 10 treatment treatment NOUN ct-9697 20 11 of of ADP ct-9697 20 12 amniotic amniotic ADJ ct-9697 20 13 infection infection NOUN ct-9697 20 14 using use VERB ct-9697 20 15 tlr tlr PROPN ct-9697 20 16 antagonists antagonist NOUN ct-9697 20 17 ( ( PUNCT ct-9697 20 18 tlra tlra NOUN ct-9697 20 19 ) ) PUNCT ct-9697 20 20 resulted result VERB ct-9697 20 21 in in ADP ct-9697 20 22 a a DET ct-9697 20 23 downregulation downregulation NOUN ct-9697 20 24 of of ADP ct-9697 20 25 proinflammatory proinflammatory ADJ ct-9697 20 26 cytokines cytokine NOUN ct-9697 20 27 with with ADP ct-9697 20 28 subsequent subsequent ADJ ct-9697 20 29 delay delay NOUN ct-9697 20 30 or or CCONJ ct-9697 20 31 prevention prevention NOUN ct-9697 20 32 of of ADP ct-9697 20 33 preterm preterm NOUN ct-9697 20 34 birth.13 birth.13 NOUN ct-9697 20 35 in in ADP ct-9697 20 36 prepartum prepartum NOUN ct-9697 20 37 myometrium myometrium NOUN ct-9697 20 38 , , PUNCT ct-9697 20 39 we we PRON ct-9697 20 40 identified identify VERB ct-9697 20 41 upregulation upregulation NOUN ct-9697 20 42 of of ADP ct-9697 20 43 several several ADJ ct-9697 20 44 inflammation inflammation NOUN ct-9697 20 45 related relate VERB ct-9697 20 46 genes gene NOUN ct-9697 20 47 ( ( PUNCT ct-9697 20 48 e.g. e.g. ADV ct-9697 20 49 ↓srd5a1 ↓srd5a1 X ct-9697 20 50 ↓akr1c23 ↓akr1c23 PRON ct-9697 20 51 ↓pr ↓pr X ct-9697 20 52 ↓3α ↓3α PROPN ct-9697 20 53 - - PUNCT ct-9697 20 54 dhp dhp ADJ ct-9697 20 55 ↓20α ↓20α NOUN ct-9697 20 56 - - PUNCT ct-9697 20 57 dhp dhp PROPN ct-9697 20 58 ↓5α ↓5α PROPN ct-9697 20 59 - - PUNCT ct-9697 20 60 dhpp4 dhpp4 NOUN ct-9697 20 61 progestins progestin NOUN ct-9697 20 62 withdrawal withdrawal NOUN ct-9697 20 63 progestin progestin NOUN ct-9697 20 64 functional functional ADJ ct-9697 20 65 withdrawal withdrawal NOUN ct-9697 20 66 downregulation downregulation NOUN ct-9697 20 67 in in ADP ct-9697 20 68 progestin progestin NOUN ct-9697 20 69 signaling signal VERB ct-9697 20 70 myometrial myometrial ADJ ct-9697 20 71 activation activation NOUN ct-9697 20 72 myometrium myometrium NOUN ct-9697 20 73 ( ( PUNCT ct-9697 20 74 acute acute PROPN ct-9697 20 75 placentitis placentitis PROPN ct-9697 20 76 ) ) PUNCT ct-9697 20 77 ↑ ↑ PROPN ct-9697 20 78 pro pro ADJ ct-9697 20 79 - - ADJ ct-9697 20 80 inflammatory inflammatory ADJ ct-9697 20 81 cytokines↑ cytokines↑ ADJ ct-9697 20 82 contraction contraction NOUN ct-9697 20 83 - - PUNCT ct-9697 20 84 associated associate VERB ct-9697 20 85 proteins protein NOUN ct-9697 20 86 placentitispregnancy placentitispregnancy NOUN ct-9697 20 87 myometrial myometrial ADJ ct-9697 20 88 activation activation NOUN ct-9697 20 89 myometrial myometrial ADJ ct-9697 20 90 quiescence quiescence NOUN ct-9697 20 91 ↑pr ↑pr NOUN ct-9697 20 92 - - PUNCT ct-9697 20 93 b b NOUN ct-9697 20 94 / / SYM ct-9697 20 95 pr pr NOUN ct-9697 20 96 - - PUNCT ct-9697 20 97 a a DET ct-9697 20 98 ↓pr ↓pr NOUN ct-9697 20 99 - - PUNCT ct-9697 20 100 b b NOUN ct-9697 20 101 / / SYM ct-9697 20 102 pr pr NOUN ct-9697 20 103 - - PUNCT ct-9697 20 104 a a PRON ct-9697 20 105 a a NOUN ct-9697 20 106 ) ) PUNCT ct-9697 20 107 b b NOUN ct-9697 20 108 ) ) PUNCT ct-9697 20 109 clinical clinical ADJ ct-9697 20 110 theriogenology theriogenology NOUN ct-9697 20 111 • • NOUN ct-9697 20 112 volume volume NOUN ct-9697 20 113 12 12 NUM ct-9697 20 114 number number NOUN ct-9697 20 115 3 3 NUM ct-9697 20 116 • • NUM ct-9697 20 117 september september PROPN ct-9697 20 118 2020 2020 NUM ct-9697 20 119 341 341 NUM ct-9697 20 120 tnfaip6 tnfaip6 NOUN ct-9697 20 121 , , PUNCT ct-9697 20 122 icam1 icam1 PROPN ct-9697 20 123 , , PUNCT ct-9697 20 124 socs3 socs3 ADJ ct-9697 20 125 , , PUNCT ct-9697 20 126 cxcr4).2 cxcr4).2 NOUN ct-9697 20 127 upregulation upregulation NOUN ct-9697 20 128 of of ADP ct-9697 20 129 these these DET ct-9697 20 130 genes gene NOUN ct-9697 20 131 might might AUX ct-9697 20 132 reflect reflect VERB ct-9697 20 133 presence presence NOUN ct-9697 20 134 of of ADP ct-9697 20 135 sterile sterile ADJ ct-9697 20 136 inflammatory inflammatory NOUN ct-9697 20 137 signaling signal VERB ct-9697 20 138 in in ADP ct-9697 20 139 myometrium myometrium NOUN ct-9697 20 140 during during ADP ct-9697 20 141 prepartum prepartum NOUN ct-9697 20 142 stage stage NOUN ct-9697 20 143 in in ADP ct-9697 20 144 mare mare PROPN ct-9697 20 145 . . PUNCT ct-9697 21 1 myometrial myometrial ADJ ct-9697 21 2 infiltration infiltration NOUN ct-9697 21 3 with with ADP ct-9697 21 4 leukocytes leukocyte NOUN ct-9697 21 5 in in ADP ct-9697 21 6 women woman NOUN ct-9697 21 7 , , PUNCT ct-9697 21 8 myometrial myometrial ADJ ct-9697 21 9 infiltration infiltration NOUN ct-9697 21 10 with with ADP ct-9697 21 11 leukocytes leukocyte NOUN ct-9697 21 12 is be AUX ct-9697 21 13 hallmark hallmark ADJ ct-9697 21 14 of of ADP ct-9697 21 15 switching switch VERB ct-9697 21 16 myometrium myometrium NOUN ct-9697 21 17 from from ADP ct-9697 21 18 a a DET ct-9697 21 19 quiescent quiescent NOUN ct-9697 21 20 to to ADP ct-9697 21 21 a a DET ct-9697 21 22 contractile contractile NOUN ct-9697 21 23 state state NOUN ct-9697 21 24 during during ADP ct-9697 21 25 term term NOUN ct-9697 21 26 and and CCONJ ct-9697 21 27 preterm preterm NOUN ct-9697 21 28 labor.14 labor.14 NOUN ct-9697 21 29 - - PROPN ct-9697 21 30 16 16 NUM ct-9697 21 31 similarly similarly ADV ct-9697 21 32 , , PUNCT ct-9697 21 33 we we PRON ct-9697 21 34 reported report VERB ct-9697 21 35 that that SCONJ ct-9697 21 36 equine equine NOUN ct-9697 21 37 placentitis placentitis PROPN ct-9697 21 38 is be AUX ct-9697 21 39 associated associate VERB ct-9697 21 40 with with ADP ct-9697 21 41 increased increase VERB ct-9697 21 42 myometrial myometrial ADJ ct-9697 21 43 infiltration infiltration NOUN ct-9697 21 44 with with ADP ct-9697 21 45 leukocytes.1,2 leukocytes.1,2 PROPN ct-9697 21 46 moreover moreover ADV ct-9697 21 47 , , PUNCT ct-9697 21 48 we we PRON ct-9697 21 49 elucidated elucidate VERB ct-9697 21 50 chemokine chemokine ADJ ct-9697 21 51 signaling signal VERB ct-9697 21 52 mechanisms mechanism NOUN ct-9697 21 53 implicated implicate VERB ct-9697 21 54 in in ADP ct-9697 21 55 upregulation upregulation NOUN ct-9697 21 56 of of ADP ct-9697 21 57 several several ADJ ct-9697 21 58 chemotactic chemotactic ADJ ct-9697 21 59 factors factor NOUN ct-9697 21 60 including include VERB ct-9697 21 61 ; ; PUNCT ct-9697 21 62 c c X ct-9697 21 63 - - PUNCT ct-9697 21 64 c c NOUN ct-9697 21 65 motif motif NOUN ct-9697 21 66 chemokine chemokine ADJ ct-9697 21 67 ligand ligand NOUN ct-9697 21 68 ( ( PUNCT ct-9697 21 69 ccl2 ccl2 PROPN ct-9697 21 70 , , PUNCT ct-9697 21 71 4 4 NUM ct-9697 21 72 , , PUNCT ct-9697 21 73 and and CCONJ ct-9697 21 74 8) 8) NUM ct-9697 21 75 , , PUNCT ct-9697 21 76 c c NOUN ct-9697 21 77 - - PUNCT ct-9697 21 78 x x NOUN ct-9697 21 79 - - NOUN ct-9697 21 80 c c ADJ ct-9697 21 81 motif motif NOUN ct-9697 21 82 chemokine chemokine ADJ ct-9697 21 83 ligand ligand NOUN ct-9697 21 84 ( ( PUNCT ct-9697 21 85 cxcl1 cxcl1 PROPN ct-9697 21 86 , , PUNCT ct-9697 21 87 2 2 NUM ct-9697 21 88 , , PUNCT ct-9697 21 89 3 3 NUM ct-9697 21 90 , , PUNCT ct-9697 21 91 6 6 NUM ct-9697 21 92 , , PUNCT ct-9697 21 93 8 8 NUM ct-9697 21 94 , , PUNCT ct-9697 21 95 and and CCONJ ct-9697 21 96 9 9 NUM ct-9697 21 97 ) ) PUNCT ct-9697 21 98 and and CCONJ ct-9697 21 99 calgranulins calgranulin NOUN ct-9697 21 100 ( ( PUNCT ct-9697 21 101 s100a8 s100a8 PROPN ct-9697 21 102 and and CCONJ ct-9697 21 103 s100a9).1,2 s100a9).1,2 VERB ct-9697 21 104 in in ADP ct-9697 21 105 equine equine NOUN ct-9697 21 106 prepartum prepartum NOUN ct-9697 21 107 myometrium myometrium NOUN ct-9697 21 108 ( ( PUNCT ct-9697 21 109 330 330 NUM ct-9697 21 110 days day NOUN ct-9697 21 111 ga ga PROPN ct-9697 21 112 ) ) PUNCT ct-9697 21 113 , , PUNCT ct-9697 21 114 although although SCONJ ct-9697 21 115 we we PRON ct-9697 21 116 identified identify VERB ct-9697 21 117 upregulation upregulation NOUN ct-9697 21 118 of of ADP ct-9697 21 119 ccl2 ccl2 PROPN ct-9697 21 120 , , PUNCT ct-9697 21 121 cxcl1 cxcl1 PROPN ct-9697 21 122 , , PUNCT ct-9697 21 123 cxcl3 cxcl3 PROPN ct-9697 21 124 , , PUNCT ct-9697 21 125 and and CCONJ ct-9697 21 126 cxcl6 cxcl6 PROPN ct-9697 21 127 , , PUNCT ct-9697 21 128 we we PRON ct-9697 21 129 did do AUX ct-9697 21 130 not not PART ct-9697 21 131 observe observe VERB ct-9697 21 132 marked mark VERB ct-9697 21 133 leukocytic leukocytic ADJ ct-9697 21 134 infiltration infiltration NOUN ct-9697 21 135 in in ADP ct-9697 21 136 myometrium.2 myometrium.2 PROPN ct-9697 21 137 this this PRON ct-9697 21 138 might might AUX ct-9697 21 139 reflect reflect VERB ct-9697 21 140 an an DET ct-9697 21 141 early early ADJ ct-9697 21 142 chemotaxis chemotaxis ADJ ct-9697 21 143 event event NOUN ct-9697 21 144 taking take VERB ct-9697 21 145 place place NOUN ct-9697 21 146 in in ADP ct-9697 21 147 prepartum prepartum NOUN ct-9697 21 148 myometrium myometrium NOUN ct-9697 21 149 in in ADP ct-9697 21 150 preparation preparation NOUN ct-9697 21 151 for for ADP ct-9697 21 152 labor labor NOUN ct-9697 21 153 . . PUNCT ct-9697 22 1 myometrial myometrial ADJ ct-9697 22 2 apoptosis apoptosis NOUN ct-9697 22 3 during during ADP ct-9697 22 4 placentitis placentitis PROPN ct-9697 22 5 , , PUNCT ct-9697 22 6 equine equine NOUN ct-9697 22 7 myometrium myometrium NOUN ct-9697 22 8 is be AUX ct-9697 22 9 associated associate VERB ct-9697 22 10 with with ADP ct-9697 22 11 a a DET ct-9697 22 12 significant significant ADJ ct-9697 22 13 upregulation upregulation NOUN ct-9697 22 14 of of ADP ct-9697 22 15 apoptosis apoptosis NOUN ct-9697 22 16 related relate VERB ct-9697 22 17 transcripts transcript NOUN ct-9697 22 18 , , PUNCT ct-9697 22 19 including include VERB ct-9697 22 20 : : PUNCT ct-9697 22 21 caspases caspase NOUN ct-9697 22 22 ( ( PUNCT ct-9697 22 23 casp3 casp3 NOUN ct-9697 22 24 , , PUNCT ct-9697 22 25 casp4 casp4 PROPN ct-9697 22 26 , , PUNCT ct-9697 22 27 casp7 casp7 PROPN ct-9697 22 28 ) ) PUNCT ct-9697 22 29 , , PUNCT ct-9697 22 30 activating activate VERB ct-9697 22 31 transcription transcription NOUN ct-9697 22 32 factor factor NOUN ct-9697 22 33 3 3 NUM ct-9697 22 34 ( ( PUNCT ct-9697 22 35 atf3 atf3 NOUN ct-9697 22 36 ) ) PUNCT ct-9697 22 37 , , PUNCT ct-9697 22 38 fas fas PROPN ct-9697 22 39 cell cell NOUN ct-9697 22 40 surface surface NOUN ct-9697 22 41 death death NOUN ct-9697 22 42 receptor receptor NOUN ct-9697 22 43 ( ( PUNCT ct-9697 22 44 fas fas NOUN ct-9697 22 45 ) ) PUNCT ct-9697 22 46 , , PUNCT ct-9697 22 47 fos fos VERB ct-9697 22 48 proto proto NOUN ct-9697 22 49 - - PUNCT ct-9697 22 50 oncogene oncogene ADJ ct-9697 22 51 subunit subunit NOUN ct-9697 22 52 ( ( PUNCT ct-9697 22 53 fos fos NOUN ct-9697 22 54 ) ) PUNCT ct-9697 22 55 , , PUNCT ct-9697 22 56 activator activator NOUN ct-9697 22 57 protein protein NOUN ct-9697 22 58 1 1 NUM ct-9697 22 59 ( ( PUNCT ct-9697 22 60 ap-1 ap-1 NOUN ct-9697 22 61 ) ) PUNCT ct-9697 22 62 , , PUNCT ct-9697 22 63 and and CCONJ ct-9697 22 64 baculoviral baculoviral PROPN ct-9697 22 65 iap iap PROPN ct-9697 22 66 repeat repeat PROPN ct-9697 22 67 containing contain VERB ct-9697 22 68 3 3 NUM ct-9697 22 69 ( ( PUNCT ct-9697 22 70 birc3).2 birc3).2 ADP ct-9697 22 71 myometrial myometrial ADJ ct-9697 22 72 apoptosis apoptosis NOUN ct-9697 22 73 occurred occur VERB ct-9697 22 74 during during ADP ct-9697 22 75 chorioamnionitis chorioamnionitis PROPN ct-9697 22 76 in in ADP ct-9697 22 77 women17,18 women17,18 PROPN ct-9697 22 78 and and CCONJ ct-9697 22 79 infection infection NOUN ct-9697 22 80 - - PUNCT ct-9697 22 81 induced induce VERB ct-9697 22 82 labor labor NOUN ct-9697 22 83 in in ADP ct-9697 22 84 mice.19 mice.19 NOUN ct-9697 22 85 additionally additionally ADV ct-9697 22 86 , , PUNCT ct-9697 22 87 apoptosis apoptosis NOUN ct-9697 22 88 by by ADP ct-9697 22 89 itself itself PRON ct-9697 22 90 might might AUX ct-9697 22 91 be be AUX ct-9697 22 92 a a DET ct-9697 22 93 key key ADJ ct-9697 22 94 event event NOUN ct-9697 22 95 in in ADP ct-9697 22 96 switching switch VERB ct-9697 22 97 myometrial myometrial ADJ ct-9697 22 98 cells cell NOUN ct-9697 22 99 from from ADP ct-9697 22 100 quiescent quiescent ADJ ct-9697 22 101 to to ADP ct-9697 22 102 contractile contractile VERB ct-9697 22 103 status.17,18,20 status.17,18,20 X ct-9697 22 104 uterine uterine ADJ ct-9697 22 105 contraction contraction NOUN ct-9697 22 106 associated associate VERB ct-9697 22 107 genes gene NOUN ct-9697 22 108 placentitis placentitis PROPN ct-9697 22 109 induced induce VERB ct-9697 22 110 myometrial myometrial ADJ ct-9697 22 111 inflammation inflammation NOUN ct-9697 22 112 is be AUX ct-9697 22 113 associated associate VERB ct-9697 22 114 with with ADP ct-9697 22 115 upregulation upregulation NOUN ct-9697 22 116 of of ADP ct-9697 22 117 several several ADJ ct-9697 22 118 contraction contraction NOUN ct-9697 22 119 - - PUNCT ct-9697 22 120 associated associate VERB ct-9697 22 121 transcripts transcript NOUN ct-9697 22 122 , , PUNCT ct-9697 22 123 including include VERB ct-9697 22 124 prostaglandin prostaglandin VERB ct-9697 22 125 endoperoxide endoperoxide ADJ ct-9697 22 126 synthase synthase NOUN ct-9697 22 127 2 2 NUM ct-9697 22 128 ( ( PUNCT ct-9697 22 129 ptgs2 ptgs2 PROPN ct-9697 22 130 , , PUNCT ct-9697 22 131 also also ADV ct-9697 22 132 cyclooxygenase cyclooxygenase VERB ct-9697 22 133 2 2 NUM ct-9697 22 134 ; ; PUNCT ct-9697 22 135 cox2 cox2 PROPN ct-9697 22 136 ) ) PUNCT ct-9697 22 137 , , PUNCT ct-9697 22 138 prostaglandin prostaglandin NOUN ct-9697 22 139 e e NOUN ct-9697 22 140 receptor receptor NOUN ct-9697 22 141 3 3 NUM ct-9697 22 142 ( ( PUNCT ct-9697 22 143 ptger3 ptger3 NOUN ct-9697 22 144 ) ) PUNCT ct-9697 22 145 , , PUNCT ct-9697 22 146 gap gap NOUN ct-9697 22 147 junction junction NOUN ct-9697 22 148 alpha alpha NOUN ct-9697 22 149 4 4 NUM ct-9697 22 150 ( ( PUNCT ct-9697 22 151 gja4 gja4 PROPN ct-9697 22 152 , , PUNCT ct-9697 22 153 also also ADV ct-9697 22 154 known know VERB ct-9697 22 155 as as ADP ct-9697 22 156 connexin-37 connexin-37 PROPN ct-9697 22 157 ; ; PUNCT ct-9697 22 158 cxn37 cxn37 PROPN ct-9697 22 159 or or CCONJ ct-9697 22 160 cx37 cx37 PROPN ct-9697 22 161 ) ) PUNCT ct-9697 22 162 , , PUNCT ct-9697 22 163 matrix matrix NOUN ct-9697 22 164 metallopeptidases metallopeptidase NOUN ct-9697 22 165 ( ( PUNCT ct-9697 22 166 mmp1 mmp1 NOUN ct-9697 22 167 and and CCONJ ct-9697 22 168 mmp8 mmp8 PROPN ct-9697 22 169 ) ) PUNCT ct-9697 22 170 plus plus CCONJ ct-9697 22 171 downregulation downregulation NOUN ct-9697 22 172 relaxin relaxin NOUN ct-9697 22 173 ( ( PUNCT ct-9697 22 174 rln).2 rln).2 PRON ct-9697 22 175 role role NOUN ct-9697 22 176 of of ADP ct-9697 22 177 these these DET ct-9697 22 178 genes gene NOUN ct-9697 22 179 in in ADP ct-9697 22 180 myometrial myometrial ADJ ct-9697 22 181 activation activation NOUN ct-9697 22 182 during during ADP ct-9697 22 183 term term NOUN ct-9697 22 184 and and CCONJ ct-9697 22 185 preterm preterm ADJ ct-9697 22 186 labor labor NOUN ct-9697 22 187 is be AUX ct-9697 22 188 well well ADV ct-9697 22 189 established establish VERB ct-9697 22 190 in in ADP ct-9697 22 191 women woman NOUN ct-9697 22 192 and and CCONJ ct-9697 22 193 mice.21 mice.21 VERB ct-9697 22 194 for for ADP ct-9697 22 195 example example NOUN ct-9697 22 196 , , PUNCT ct-9697 22 197 ptgs2 ptgs2 PROPN ct-9697 22 198 is be AUX ct-9697 22 199 essential essential ADJ ct-9697 22 200 for for ADP ct-9697 22 201 synthesis synthesis NOUN ct-9697 22 202 of of ADP ct-9697 22 203 prostaglandin prostaglandin NOUN ct-9697 22 204 f2α f2α PROPN ct-9697 22 205 ( ( PUNCT ct-9697 22 206 pgf2α pgf2α PROPN ct-9697 22 207 ) ) PUNCT ct-9697 22 208 , , PUNCT ct-9697 22 209 which which PRON ct-9697 22 210 is be AUX ct-9697 22 211 a a DET ct-9697 22 212 potent potent ADJ ct-9697 22 213 uterotonic uterotonic ADJ ct-9697 22 214 ( ( PUNCT ct-9697 22 215 ecbolic).21 ecbolic).21 PROPN ct-9697 22 216 contrarily contrarily ADV ct-9697 22 217 , , PUNCT ct-9697 22 218 gjas gjas PROPN ct-9697 22 219 are be AUX ct-9697 22 220 believed believe VERB ct-9697 22 221 to to PART ct-9697 22 222 play play VERB ct-9697 22 223 a a DET ct-9697 22 224 critical critical ADJ ct-9697 22 225 role role NOUN ct-9697 22 226 in in ADP ct-9697 22 227 preterm preterm NOUN ct-9697 22 228 and and CCONJ ct-9697 22 229 term term NOUN ct-9697 22 230 labor labor NOUN ct-9697 22 231 by by ADP ct-9697 22 232 forming form VERB ct-9697 22 233 gap gap NOUN ct-9697 22 234 junctions junction NOUN ct-9697 22 235 in in ADP ct-9697 22 236 myometrium myometrium NOUN ct-9697 22 237 , , PUNCT ct-9697 22 238 which which PRON ct-9697 22 239 increase increase VERB ct-9697 22 240 myometrial myometrial ADJ ct-9697 22 241 cell cell NOUN ct-9697 22 242 coupling coupling NOUN ct-9697 22 243 with with ADP ct-9697 22 244 subsequent subsequent ADJ ct-9697 22 245 generation generation NOUN ct-9697 22 246 of of ADP ct-9697 22 247 synchronous synchronous ADJ ct-9697 22 248 myometrial myometrial ADJ ct-9697 22 249 contractions.21 contractions.21 PROPN ct-9697 22 250 - - PUNCT ct-9697 22 251 24 24 NUM ct-9697 22 252 cervical cervical ADJ ct-9697 22 253 remodeling remodeling NOUN ct-9697 22 254 cervical cervical ADJ ct-9697 22 255 remodeling remodeling NOUN ct-9697 22 256 is be AUX ct-9697 22 257 transformation transformation NOUN ct-9697 22 258 of of ADP ct-9697 22 259 cervix cervix NOUN ct-9697 22 260 from from ADP ct-9697 22 261 a a DET ct-9697 22 262 rigid rigid ADJ ct-9697 22 263 , , PUNCT ct-9697 22 264 tightly tightly ADV ct-9697 22 265 closed closed ADJ ct-9697 22 266 structure structure NOUN ct-9697 22 267 into into ADP ct-9697 22 268 a a DET ct-9697 22 269 flaccid flaccid NOUN ct-9697 22 270 and and CCONJ ct-9697 22 271 open open VERB ct-9697 22 272 one one NUM ct-9697 22 273 to to PART ct-9697 22 274 permit permit VERB ct-9697 22 275 fetal fetal ADJ ct-9697 22 276 delivery delivery NOUN ct-9697 22 277 during during ADP ct-9697 22 278 term term NOUN ct-9697 22 279 and and CCONJ ct-9697 22 280 preterm preterm ADJ ct-9697 22 281 labor.25 labor.25 PROPN ct-9697 22 282 - - PUNCT ct-9697 22 283 27 27 NUM ct-9697 22 284 cervical cervical ADJ ct-9697 22 285 remodeling remodeling NOUN ct-9697 22 286 consists consist VERB ct-9697 22 287 of of ADP ct-9697 22 288 4 4 NUM ct-9697 22 289 overlapping overlap VERB ct-9697 22 290 phases phase NOUN ct-9697 22 291 ( ( PUNCT ct-9697 22 292 i.e. i.e. X ct-9697 22 293 softening soften VERB ct-9697 22 294 , , PUNCT ct-9697 22 295 ripening ripening NOUN ct-9697 22 296 , , PUNCT ct-9697 22 297 dilation dilation NOUN ct-9697 22 298 , , PUNCT ct-9697 22 299 and and CCONJ ct-9697 22 300 postpartum postpartum NOUN ct-9697 22 301 repair).25 repair).25 PROPN ct-9697 22 302 - - PUNCT ct-9697 22 303 27 27 NUM ct-9697 22 304 cervical cervical ADJ ct-9697 22 305 remodeling remodeling NOUN ct-9697 22 306 requires require VERB ct-9697 22 307 decreases decrease NOUN ct-9697 22 308 in in ADP ct-9697 22 309 cervical cervical ADJ ct-9697 22 310 collagen collagen NOUN ct-9697 22 311 concentrations concentration NOUN ct-9697 22 312 ( ( PUNCT ct-9697 22 313 i.e. i.e. X ct-9697 22 314 extracellular extracellular ADJ ct-9697 22 315 matrix matrix NOUN ct-9697 22 316 ( ( PUNCT ct-9697 22 317 ecm ecm NOUN ct-9697 22 318 ) ) PUNCT ct-9697 22 319 degradation degradation NOUN ct-9697 22 320 ) ) PUNCT ct-9697 22 321 and and CCONJ ct-9697 22 322 wide wide ADJ ct-9697 22 323 dispersing dispersing NOUN ct-9697 22 324 of of ADP ct-9697 22 325 collagen collagen NOUN ct-9697 22 326 fibers fiber NOUN ct-9697 22 327 through through ADP ct-9697 22 328 increasing increase VERB ct-9697 22 329 cervical cervical ADJ ct-9697 22 330 water water NOUN ct-9697 22 331 content content NOUN ct-9697 22 332 ( ( PUNCT ct-9697 22 333 i.e. i.e. X ct-9697 22 334 cervical cervical ADJ ct-9697 22 335 hydration hydration NOUN ct-9697 22 336 ) ) PUNCT ct-9697 22 337 , , PUNCT ct-9697 22 338 with with ADP ct-9697 22 339 subsequent subsequent ADJ ct-9697 22 340 decrease decrease NOUN ct-9697 22 341 of of ADP ct-9697 22 342 cervical cervical ADJ ct-9697 22 343 tensile tensile NOUN ct-9697 22 344 strength strength NOUN ct-9697 22 345 to to PART ct-9697 22 346 allow allow VERB ct-9697 22 347 cervical cervical ADJ ct-9697 22 348 dilation.28 dilation.28 NOUN ct-9697 22 349 mechanisms mechanism NOUN ct-9697 22 350 underlying underlie VERB ct-9697 22 351 cervical cervical ADJ ct-9697 22 352 remodeling remodeling NOUN ct-9697 22 353 events event NOUN ct-9697 22 354 during during ADP ct-9697 22 355 equine equine NOUN ct-9697 22 356 placentitis placentitis PROPN ct-9697 22 357 and and CCONJ ct-9697 22 358 normal normal ADJ ct-9697 22 359 prepartum prepartum NOUN ct-9697 22 360 period period NOUN ct-9697 22 361 are be AUX ct-9697 22 362 summarized summarize VERB ct-9697 22 363 below below ADP ct-9697 22 364 . . PUNCT ct-9697 23 1 extracellular extracellular ADJ ct-9697 23 2 matrix matrix NOUN ct-9697 23 3 ( ( PUNCT ct-9697 23 4 ecm ecm PROPN ct-9697 23 5 ) ) PUNCT ct-9697 23 6 degradation degradation NOUN ct-9697 23 7 during during ADP ct-9697 23 8 placentitis placentitis PROPN ct-9697 23 9 , , PUNCT ct-9697 23 10 we we PRON ct-9697 23 11 reported report VERB ct-9697 23 12 upregulation upregulation NOUN ct-9697 23 13 of of ADP ct-9697 23 14 several several ADJ ct-9697 23 15 proteases protease NOUN ct-9697 23 16 , , PUNCT ct-9697 23 17 including include VERB ct-9697 23 18 mmps mmp NOUN ct-9697 23 19 ( ( PUNCT ct-9697 23 20 e.g. e.g. ADV ct-9697 23 21 mmp1 mmp1 PROPN ct-9697 23 22 , , PUNCT ct-9697 23 23 8 8 NUM ct-9697 23 24 , , PUNCT ct-9697 23 25 13 13 NUM ct-9697 23 26 and and CCONJ ct-9697 23 27 14).29 14).29 NUM ct-9697 23 28 these these DET ct-9697 23 29 mmps mmp NOUN ct-9697 23 30 are be AUX ct-9697 23 31 believed believe VERB ct-9697 23 32 implicated implicate VERB ct-9697 23 33 in in ADP ct-9697 23 34 cervical cervical ADJ ct-9697 23 35 collagen collagen NOUN ct-9697 23 36 degradation degradation NOUN ct-9697 23 37 during during ADP ct-9697 23 38 equine equine NOUN ct-9697 23 39 placentitis.29 placentitis.29 NOUN ct-9697 23 40 contrarily contrarily ADV ct-9697 23 41 , , PUNCT ct-9697 23 42 cervix cervix NOUN ct-9697 23 43 from from ADP ct-9697 23 44 prepartum prepartum NOUN ct-9697 23 45 mares mare NOUN ct-9697 23 46 ( ( PUNCT ct-9697 23 47 330 330 NUM ct-9697 23 48 d d PROPN ct-9697 23 49 ga ga PROPN ct-9697 23 50 ) ) PUNCT ct-9697 23 51 was be AUX ct-9697 23 52 not not PART ct-9697 23 53 associated associate VERB ct-9697 23 54 with with ADP ct-9697 23 55 significant significant ADJ ct-9697 23 56 change change NOUN ct-9697 23 57 in in ADP ct-9697 23 58 mmps mmp NOUN ct-9697 23 59 expression expression NOUN ct-9697 23 60 . . PUNCT ct-9697 24 1 clinical clinical ADJ ct-9697 24 2 theriogenology theriogenology NOUN ct-9697 24 3 • • NOUN ct-9697 24 4 volume volume NOUN ct-9697 24 5 12 12 NUM ct-9697 24 6 number number NOUN ct-9697 24 7 3 3 NUM ct-9697 24 8 • • NOUN ct-9697 24 9 september september PROPN ct-9697 24 10 2020342 2020342 NUM ct-9697 24 11 figure figure NOUN ct-9697 24 12 2 2 NUM ct-9697 24 13 . . PUNCT ct-9697 24 14 inflammatory inflammatory ADJ ct-9697 24 15 events event NOUN ct-9697 24 16 and and CCONJ ct-9697 24 17 associated associate VERB ct-9697 24 18 molecular molecular ADJ ct-9697 24 19 mechanisms mechanism NOUN ct-9697 24 20 in in ADP ct-9697 24 21 equine equine NOUN ct-9697 24 22 myometrium myometrium NOUN ct-9697 24 23 during during ADP ct-9697 24 24 placentitis placentitis PROPN ct-9697 24 25 ( ( PUNCT ct-9697 24 26 a a NOUN ct-9697 24 27 ) ) PUNCT ct-9697 24 28 and and CCONJ ct-9697 24 29 prepatum prepatum ADJ ct-9697 24 30 period period NOUN ct-9697 24 31 ( ( PUNCT ct-9697 24 32 b b NOUN ct-9697 24 33 ) ) PUNCT ct-9697 24 34 . . PUNCT ct-9697 25 1 cervical cervical ADJ ct-9697 25 2 hydration hydration NOUN ct-9697 25 3 along along ADP ct-9697 25 4 with with ADP ct-9697 25 5 ecm ecm NOUN ct-9697 25 6 degradation degradation NOUN ct-9697 25 7 , , PUNCT ct-9697 25 8 cervical cervical ADJ ct-9697 25 9 hydration hydration NOUN ct-9697 25 10 is be AUX ct-9697 25 11 another another DET ct-9697 25 12 important important ADJ ct-9697 25 13 component component NOUN ct-9697 25 14 in in ADP ct-9697 25 15 cervical cervical ADJ ct-9697 25 16 remodeling remodeling NOUN ct-9697 25 17 in in ADP ct-9697 25 18 which which PRON ct-9697 25 19 water water NOUN ct-9697 25 20 content content NOUN ct-9697 25 21 increases increase VERB ct-9697 25 22 in in ADP ct-9697 25 23 cervical cervical ADJ ct-9697 25 24 tissue tissue NOUN ct-9697 25 25 , , PUNCT ct-9697 25 26 reducing reduce VERB ct-9697 25 27 collagen collagen NOUN ct-9697 25 28 density.29 density.29 NOUN ct-9697 25 29 cervical cervical ADJ ct-9697 25 30 hydration hydration NOUN ct-9697 25 31 could could AUX ct-9697 25 32 be be AUX ct-9697 25 33 achieved achieve VERB ct-9697 25 34 through through ADP ct-9697 25 35 various various ADJ ct-9697 25 36 mechanisms mechanism NOUN ct-9697 25 37 , , PUNCT ct-9697 25 38 e.g. e.g. ADV ct-9697 25 39 upregulation upregulation NOUN ct-9697 25 40 of of ADP ct-9697 25 41 aquaporins aquaporin NOUN ct-9697 25 42 ( ( PUNCT ct-9697 25 43 aqps aqps NOUN ct-9697 25 44 ) ) PUNCT ct-9697 25 45 water water NOUN ct-9697 25 46 channels channel NOUN ct-9697 25 47 and and CCONJ ct-9697 25 48 hydrophilic hydrophilic ADJ ct-9697 25 49 proteoglycans proteoglycan NOUN ct-9697 25 50 , , PUNCT ct-9697 25 51 as as ADV ct-9697 25 52 well well ADV ct-9697 25 53 as as ADP ct-9697 25 54 increased increase VERB ct-9697 25 55 vascular vascular ADJ ct-9697 25 56 permeability.25 permeability.25 NOUN ct-9697 25 57 - - PUNCT ct-9697 25 58 27,29 27,29 NUM ct-9697 25 59 for for ADP ct-9697 25 60 instance instance NOUN ct-9697 25 61 , , PUNCT ct-9697 25 62 cervical cervical ADJ ct-9697 25 63 remodeling remodeling NOUN ct-9697 25 64 during during ADP ct-9697 25 65 placentitis placentitis PROPN ct-9697 25 66 is be AUX ct-9697 25 67 associated associate VERB ct-9697 25 68 with with ADP ct-9697 25 69 upregulation upregulation NOUN ct-9697 25 70 of of ADP ct-9697 25 71 aqp9 aqp9 PROPN ct-9697 25 72 ( ( PUNCT ct-9697 25 73 water water NOUN ct-9697 25 74 transporter transporter NOUN ct-9697 25 75 ) ) PUNCT ct-9697 25 76 , , PUNCT ct-9697 25 77 aggrecan aggrecan PROPN ct-9697 25 78 ( ( PUNCT ct-9697 25 79 acan acan ADJ ct-9697 25 80 ; ; PUNCT ct-9697 25 81 a a DET ct-9697 25 82 hydrophilic hydrophilic ADJ ct-9697 25 83 proteoglycan proteoglycan NOUN ct-9697 25 84 ) ) PUNCT ct-9697 25 85 , , PUNCT ct-9697 25 86 plus plus CCONJ ct-9697 25 87 vascular vascular ADJ ct-9697 25 88 permeability permeability NOUN ct-9697 25 89 - - PUNCT ct-9697 25 90 related relate VERB ct-9697 25 91 genes gene NOUN ct-9697 25 92 such such ADJ ct-9697 25 93 as as ADP ct-9697 25 94 rac rac PROPN ct-9697 25 95 family family NOUN ct-9697 25 96 small small ADJ ct-9697 25 97 gtpase gtpase NOUN ct-9697 25 98 ( ( PUNCT ct-9697 25 99 rac rac PROPN ct-9697 25 100 ) ) PUNCT ct-9697 25 101 and and CCONJ ct-9697 25 102 nitric nitric ADJ ct-9697 25 103 oxide oxide NOUN ct-9697 25 104 synthase synthase NOUN ct-9697 25 105 ( ( PUNCT ct-9697 25 106 enos eno NOUN ct-9697 25 107 , , PUNCT ct-9697 25 108 also also ADV ct-9697 25 109 known know VERB ct-9697 25 110 as as ADP ct-9697 25 111 nos3).29 nos3).29 PROPN ct-9697 25 112 altogether altogether ADV ct-9697 25 113 , , PUNCT ct-9697 25 114 these these DET ct-9697 25 115 findings finding NOUN ct-9697 25 116 highlight highlight VERB ct-9697 25 117 possible possible ADJ ct-9697 25 118 molecules molecule NOUN ct-9697 25 119 implicated implicate VERB ct-9697 25 120 in in ADP ct-9697 25 121 cervical cervical ADJ ct-9697 25 122 ecm ecm NOUN ct-9697 25 123 degradation degradation NOUN ct-9697 25 124 and and CCONJ ct-9697 25 125 cervical cervical ADJ ct-9697 25 126 hydration hydration NOUN ct-9697 25 127 during during ADP ct-9697 25 128 placentitis placentitis PROPN ct-9697 25 129 . . PUNCT ct-9697 26 1 conclusion conclusion NOUN ct-9697 26 2 this this DET ct-9697 26 3 review review NOUN ct-9697 26 4 provides provide VERB ct-9697 26 5 a a DET ct-9697 26 6 brief brief ADJ ct-9697 26 7 overview overview NOUN ct-9697 26 8 of of ADP ct-9697 26 9 key key ADJ ct-9697 26 10 regulators regulator NOUN ct-9697 26 11 and and CCONJ ct-9697 26 12 molecular molecular ADJ ct-9697 26 13 mechanisms mechanism NOUN ct-9697 26 14 underlying underlie VERB ct-9697 26 15 myometrial myometrial ADJ ct-9697 26 16 activation activation NOUN ct-9697 26 17 and and CCONJ ct-9697 26 18 cervical cervical ADJ ct-9697 26 19 remodeling remodeling NOUN ct-9697 26 20 during during ADP ct-9697 26 21 placentitis placentitis PROPN ct-9697 26 22 and and CCONJ ct-9697 26 23 prepartum prepartum NOUN ct-9697 26 24 period period NOUN ct-9697 26 25 . . PUNCT ct-9697 27 1 strategies strategy NOUN ct-9697 27 2 to to PART ct-9697 27 3 block block VERB ct-9697 27 4 identified identify VERB ct-9697 27 5 key key ADJ ct-9697 27 6 regulators regulator NOUN ct-9697 27 7 and and CCONJ ct-9697 27 8 associated associated ADJ ct-9697 27 9 pathways pathway NOUN ct-9697 27 10 ( ( PUNCT ct-9697 27 11 e.g. e.g. ADV ct-9697 27 12 using use VERB ct-9697 27 13 tlras tlra NOUN ct-9697 27 14 ) ) PUNCT ct-9697 27 15 hold hold VERB ct-9697 27 16 potential potential NOUN ct-9697 27 17 for for ADP ct-9697 27 18 therapies therapy NOUN ct-9697 27 19 to to PART ct-9697 27 20 forestall forestall VERB ct-9697 27 21 placentitis placentitis PROPN ct-9697 27 22 - - PUNCT ct-9697 27 23 induced induce VERB ct-9697 27 24 preterm preterm ADJ ct-9697 27 25 birth birth NOUN ct-9697 27 26 . . PUNCT ct-9697 28 1 acknowledgement acknowledgement NOUN ct-9697 28 2 supported support VERB ct-9697 28 3 by by ADP ct-9697 28 4 albert albert PROPN ct-9697 28 5 g. g. PROPN ct-9697 28 6 clay clay PROPN ct-9697 28 7 endowment endowment PROPN ct-9697 28 8 of of ADP ct-9697 28 9 university university PROPN ct-9697 28 10 of of ADP ct-9697 28 11 kentucky kentucky PROPN ct-9697 28 12 . . PUNCT ct-9697 29 1 ascending ascend VERB ct-9697 29 2 placentitis placentitis PROPN ct-9697 29 3 ( ( PUNCT ct-9697 29 4 streptococcus streptococcus NOUN ct-9697 29 5     SPACE ct-9697 29 6 equi equi NOUN ct-9697 29 7 subspecies subspecie NOUN ct-9697 29 8     SPACE ct-9697 29 9 zooepidemicus zooepidemicus NOUN ct-9697 29 10 ) ) PUNCT ct-9697 29 11 ↑ ↑ NOUN ct-9697 29 12 chemokines chemokine NOUN ct-9697 29 13 ( ( PUNCT ct-9697 29 14 ↑ccl2 ↑ccl2 PROPN ct-9697 29 15 , , PUNCT ct-9697 29 16     SPACE ct-9697 29 17 ↑cxcl2 ↑cxcl2 PROPN ct-9697 29 18 , , PUNCT ct-9697 29 19     SPACE ct-9697 29 20 ↑cxcl6 ↑cxcl6 PROPN ct-9697 29 21 , , PUNCT ct-9697 29 22     SPACE ct-9697 29 23 ↑s100a8 ↑s100a8 PROPN ct-9697 29 24 , , PUNCT ct-9697 29 25     SPACE ct-9697 29 26 ↑s100a9 ↑s100a9 NOUN ct-9697 29 27 , , PUNCT ct-9697 29 28 … … PUNCT ct-9697 29 29 ) ) PUNCT ct-9697 29 30 ↑ ↑ PROPN ct-9697 29 31 leukocytes leukocyte VERB ct-9697 29 32 infiltration infiltration NOUN ct-9697 29 33 & & CCONJ ct-9697 29 34 inflammatory inflammatory ADJ ct-9697 29 35 cascade cascade NOUN ct-9697 29 36 ↑ ↑ NOUN ct-9697 29 37 cytokines cytokine NOUN ct-9697 29 38 & & CCONJ ct-9697 29 39 inflammatory inflammatory ADJ ct-9697 29 40 nediators nediator NOUN ct-9697 29 41 ( ( PUNCT ct-9697 29 42 ↑il1β ↑il1β PROPN ct-9697 29 43 , , PUNCT ct-9697 29 44 ↑il1α ↑il1α PROPN ct-9697 29 45 , , PUNCT ct-9697 29 46     SPACE ct-9697 29 47 ↑il8 ↑il8 PROPN ct-9697 29 48 , , PUNCT ct-9697 29 49     SPACE ct-9697 29 50 ↑tnfaib6 ↑tnfaib6 PROPN ct-9697 29 51 , , PUNCT ct-9697 29 52     SPACE ct-9697 29 53 ↑icam1 ↑icam1 NOUN ct-9697 29 54 ) ) PUNCT ct-9697 29 55 toll toll NOUN ct-9697 29 56 - - PUNCT ct-9697 29 57 like like ADJ ct-9697 29 58 receptors receptor NOUN ct-9697 29 59 activation activation NOUN ct-9697 29 60 ↑tlr2 ↑tlr2 ADP ct-9697 29 61 prostaglandin prostaglandin ADJ ct-9697 29 62 synthase synthase NOUN ct-9697 29 63 and and CCONJ ct-9697 29 64 receptors receptor NOUN ct-9697 29 65 ( ( PUNCT ct-9697 29 66 ↑ptgs2 ↑ptgs2 PROPN ct-9697 29 67 , , PUNCT ct-9697 29 68     SPACE ct-9697 29 69 ↑ptger3 ↑ptger3 PROPN ct-9697 29 70 ) ) PUNCT ct-9697 29 71 prepartum prepartum NOUN ct-9697 29 72 period period NOUN ct-9697 29 73 ↑ ↑ PROPN ct-9697 29 74 chemokines chemokine NOUN ct-9697 29 75 ( ( PUNCT ct-9697 29 76 ↑ccl2 ↑ccl2 PROPN ct-9697 29 77 , , PUNCT ct-9697 29 78     SPACE ct-9697 29 79 ↑cxcl1 ↑cxcl1 PROPN ct-9697 29 80 , , PUNCT ct-9697 29 81     SPACE ct-9697 29 82 ↑cxcl3 ↑cxcl3 PROPN ct-9697 29 83 , , PUNCT ct-9697 29 84     SPACE ct-9697 29 85 ↑cxcl6 ↑cxcl6 PROPN ct-9697 29 86 ) ) PUNCT ct-9697 29 87 ↑ ↑ PROPN ct-9697 29 88 chemoattractants chemoattractant NOUN ct-9697 29 89 for for ADP ct-9697 29 90 leukocytes leukocyte NOUN ct-9697 29 91 infiltration infiltration NOUN ct-9697 29 92 & & CCONJ ct-9697 29 93 inflammation inflammation PROPN ct-9697 29 94 ↑ ↑ PROPN ct-9697 29 95 inflammatory inflammatory ADJ ct-9697 29 96 mediators mediator NOUN ct-9697 29 97 ( ( PUNCT ct-9697 29 98 ↑tnfaib6 ↑tnfaib6 ADJ ct-9697 29 99 , , PUNCT ct-9697 29 100     SPACE ct-9697 29 101 ↑icam1 ↑icam1 NOUN ct-9697 29 102 ) ) PUNCT ct-9697 29 103 transcription transcription NOUN ct-9697 29 104 factors factor NOUN ct-9697 29 105 ↑stat3 ↑stat3 VERB ct-9697 29 106 , , PUNCT ct-9697 29 107     SPACE ct-9697 29 108 ↑egr1 ↑egr1 PROPN ct-9697 29 109 , , PUNCT ct-9697 29 110     SPACE ct-9697 29 111 ↑f2r ↑f2r VERB ct-9697 29 112 oxidative oxidative ADJ ct-9697 29 113 stress stress NOUN ct-9697 29 114 ( ( PUNCT ct-9697 29 115 ↑dusp1 ↑dusp1 NOUN ct-9697 29 116 , , PUNCT ct-9697 29 117     SPACE ct-9697 29 118 ↑dusp5 ↑dusp5 NOUN ct-9697 29 119 , , PUNCT ct-9697 29 120     SPACE ct-9697 29 121 ↑dusp6 ↑dusp6 PROPN ct-9697 29 122 , , PUNCT ct-9697 29 123     SPACE ct-9697 29 124 ↑myc ↑myc NOUN ct-9697 29 125 ) ) PUNCT ct-9697 29 126 a a DET ct-9697 29 127 ) ) PUNCT ct-9697 29 128 b b NOUN ct-9697 29 129 ) ) PUNCT ct-9697 29 130 transcription transcription NOUN ct-9697 29 131 factors factor NOUN ct-9697 29 132 ↑stat1 ↑stat1 PROPN ct-9697 29 133 , , PUNCT ct-9697 29 134     SPACE ct-9697 29 135 ↑nfkb1a ↑nfkb1a PROPN ct-9697 29 136 , , PUNCT ct-9697 29 137     SPACE ct-9697 29 138 ↑junb ↑junb NOUN ct-9697 29 139 , , PUNCT ct-9697 29 140     SPACE ct-9697 29 141 ↑e2f1 ↑e2f1 PROPN ct-9697 29 142 , , PUNCT ct-9697 29 143     SPACE ct-9697 29 144 ↑foxm1 ↑foxm1 PROPN ct-9697 29 145 , , PUNCT ct-9697 29 146     SPACE ct-9697 29 147 ↑hif1a ↑hif1a PROPN ct-9697 29 148     SPACE ct-9697 29 149 myometrial myometrial ADJ ct-9697 29 150 activation activation NOUN ct-9697 29 151 preparation preparation NOUN ct-9697 29 152 for for ADP ct-9697 29 153 myometrial myometrial ADJ ct-9697 29 154 activation activation NOUN ct-9697 29 155 ? ? PUNCT ct-9697 30 1 clinical clinical ADJ ct-9697 30 2 theriogenology theriogenology NOUN ct-9697 30 3 • • NOUN ct-9697 30 4 volume volume NOUN ct-9697 30 5 12 12 NUM ct-9697 30 6 number number NOUN ct-9697 30 7 3 3 NUM ct-9697 30 8 • • NUM ct-9697 30 9 september september PROPN ct-9697 30 10 2020 2020 NUM ct-9697 30 11 343 343 NUM ct-9697 30 12 conflict conflict NOUN ct-9697 30 13 of of ADP ct-9697 30 14 interest interest NOUN ct-9697 30 15 none none NOUN ct-9697 30 16 to to PART ct-9697 30 17 report report VERB ct-9697 30 18 . . PUNCT ct-9697 31 1 abbreviations abbreviation NOUN ct-9697 31 2 20αdhp 20αdhp NUM ct-9697 31 3 ; ; PUNCT ct-9697 31 4 20α 20α NOUN ct-9697 31 5 - - PUNCT ct-9697 31 6 hydroxy-5α hydroxy-5α NOUN ct-9697 31 7 dihydroprogesterone dihydroprogesterone NOUN ct-9697 31 8 3αdhp 3αdhp NUM ct-9697 31 9 ; ; PUNCT ct-9697 31 10 allopregnanolone allopregnanolone NOUN ct-9697 31 11 5α 5α PROPN ct-9697 31 12 - - PUNCT ct-9697 31 13 dhp dhp PROPN ct-9697 31 14 ; ; PUNCT ct-9697 31 15 5α 5α PROPN ct-9697 31 16 - - PUNCT ct-9697 31 17 dihydroprogesterone dihydroprogesterone PROPN ct-9697 31 18 akr1c23 akr1c23 PROPN ct-9697 31 19 ; ; PUNCT ct-9697 31 20 aldo aldo PROPN ct-9697 31 21 - - PUNCT ct-9697 31 22 keto keto NOUN ct-9697 31 23 reductase reductase NOUN ct-9697 31 24 family family NOUN ct-9697 31 25 1 1 NUM ct-9697 31 26 member member NOUN ct-9697 31 27 c23 c23 PROPN ct-9697 31 28 aldh1 aldh1 PROPN ct-9697 31 29 ; ; PUNCT ct-9697 31 30 aldehyde aldehyde NOUN ct-9697 31 31 dehydrogenases dehydrogenase NOUN ct-9697 31 32 ap-1 ap-1 ADV ct-9697 31 33 ; ; PUNCT ct-9697 31 34 activator activator NOUN ct-9697 31 35 protein protein NOUN ct-9697 31 36 1 1 NUM ct-9697 31 37 aqps aqps NOUN ct-9697 31 38 ; ; PUNCT ct-9697 31 39 aquaporins aquaporin NOUN ct-9697 31 40 atf3 atf3 NOUN ct-9697 31 41 ; ; PUNCT ct-9697 31 42 activating activate VERB ct-9697 31 43 transcription transcription NOUN ct-9697 31 44 factor factor NOUN ct-9697 31 45 3 3 NUM ct-9697 31 46 birc3 birc3 NOUN ct-9697 31 47 ; ; PUNCT ct-9697 31 48 baculoviral baculoviral PROPN ct-9697 31 49 iap iap PROPN ct-9697 31 50 repeat repeat NOUN ct-9697 31 51 containing contain VERB ct-9697 31 52 3 3 NUM ct-9697 31 53 caps cap NOUN ct-9697 31 54 ; ; PUNCT ct-9697 31 55 contractions contraction NOUN ct-9697 31 56 - - PUNCT ct-9697 31 57 associated associate VERB ct-9697 31 58 proteins protein NOUN ct-9697 31 59 casp casp NOUN ct-9697 31 60 ; ; PUNCT ct-9697 31 61 caspase caspase PROPN ct-9697 31 62 ccl ccl PROPN ct-9697 31 63 ; ; PUNCT ct-9697 31 64 c c X ct-9697 31 65 - - PUNCT ct-9697 31 66 c c NOUN ct-9697 31 67 motif motif NOUN ct-9697 31 68 chemokine chemokine ADJ ct-9697 31 69 ligand ligand NOUN ct-9697 31 70 cxcl cxcl NOUN ct-9697 31 71 ; ; PUNCT ct-9697 31 72 c c X ct-9697 31 73 - - PUNCT ct-9697 31 74 x x NOUN ct-9697 31 75 - - NOUN ct-9697 31 76 c c ADJ ct-9697 31 77 motif motif NOUN ct-9697 31 78 chemokine chemokine ADJ ct-9697 31 79 ligand ligand NOUN ct-9697 31 80 cxcr4 cxcr4 NOUN ct-9697 31 81 ; ; PUNCT ct-9697 31 82 c c X ct-9697 31 83 - - PUNCT ct-9697 31 84 x x NOUN ct-9697 31 85 - - NOUN ct-9697 31 86 c c ADJ ct-9697 31 87 motif motif NOUN ct-9697 31 88 chemokine chemokine ADJ ct-9697 31 89 receptor receptor NOUN ct-9697 31 90 4 4 NUM ct-9697 31 91 dusp dusp NOUN ct-9697 31 92 ; ; PUNCT ct-9697 31 93 dual dual ADJ ct-9697 31 94 specificity specificity NOUN ct-9697 31 95 phosphatase phosphatase NOUN ct-9697 31 96 ecm ecm NOUN ct-9697 31 97 ; ; PUNCT ct-9697 31 98 extracellular extracellular ADJ ct-9697 31 99 matrix matrix NOUN ct-9697 31 100 enos eno VERB ct-9697 31 101 / / SYM ct-9697 31 102 nos3 nos3 PROPN ct-9697 31 103 ; ; PUNCT ct-9697 31 104 nitric nitric ADJ ct-9697 31 105 oxide oxide NOUN ct-9697 31 106 synthase synthase NOUN ct-9697 31 107 fas fas NOUN ct-9697 31 108 ; ; PUNCT ct-9697 31 109 fas fas PROPN ct-9697 31 110 cell cell NOUN ct-9697 31 111 surface surface NOUN ct-9697 31 112 death death NOUN ct-9697 31 113 receptor receptor NOUN ct-9697 31 114 gja4 gja4 PROPN ct-9697 31 115 / / SYM ct-9697 31 116 cxn37 cxn37 PROPN ct-9697 31 117 ; ; PUNCT ct-9697 31 118 gap gap NOUN ct-9697 31 119 junction junction NOUN ct-9697 31 120 alpha alpha NOUN ct-9697 31 121 4 4 NUM ct-9697 31 122 / / SYM ct-9697 31 123 connexin-37 connexin-37 PROPN ct-9697 31 124 icam1 icam1 PROPN ct-9697 31 125 ; ; PUNCT ct-9697 31 126 intercellular intercellular ADJ ct-9697 31 127 adhesion adhesion NOUN ct-9697 31 128 molecule molecule NOUN ct-9697 31 129 1 1 NUM ct-9697 31 130 il il PROPN ct-9697 31 131 ; ; PUNCT ct-9697 31 132 interleukin interleukin PROPN ct-9697 31 133 mmp mmp PROPN ct-9697 31 134 ; ; PUNCT ct-9697 31 135 matrix matrix NOUN ct-9697 31 136 metallopeptidases metallopeptidase NOUN ct-9697 31 137 myc myc NOUN ct-9697 31 138 ; ; PUNCT ct-9697 31 139 myc myc PROPN ct-9697 31 140 proto proto NOUN ct-9697 31 141 - - PUNCT ct-9697 31 142 oncogene oncogene NOUN ct-9697 31 143 , , PUNCT ct-9697 31 144 bhlh bhlh NOUN ct-9697 31 145 transcription transcription NOUN ct-9697 31 146 factor factor NOUN ct-9697 31 147 nf nf NOUN ct-9697 31 148 - - PUNCT ct-9697 31 149 κb κb NOUN ct-9697 31 150 ; ; PUNCT ct-9697 31 151 nuclear nuclear ADJ ct-9697 31 152 factor factor NOUN ct-9697 31 153 - - PUNCT ct-9697 31 154 κb κb NOUN ct-9697 31 155 p4 p4 NOUN ct-9697 31 156 ; ; PUNCT ct-9697 31 157 progesterone progesterone NOUN ct-9697 31 158 pgf2α pgf2α NOUN ct-9697 31 159 ; ; PUNCT ct-9697 31 160 prostaglandin prostaglandin VERB ct-9697 31 161 f2α f2α PROPN ct-9697 31 162 pr pr NOUN ct-9697 31 163 / / SYM ct-9697 31 164 pgr pgr PROPN ct-9697 31 165 ; ; PUNCT ct-9697 31 166 progesterone progesterone NOUN ct-9697 31 167 receptor receptor NOUN ct-9697 31 168 ptger3 ptger3 NOUN ct-9697 31 169 ; ; PUNCT ct-9697 31 170 prostaglandin prostaglandin NOUN ct-9697 31 171 e e NOUN ct-9697 31 172 receptor receptor NOUN ct-9697 31 173 3 3 NUM ct-9697 31 174 ptgs2 ptgs2 NOUN ct-9697 31 175 / / SYM ct-9697 31 176 cox2 cox2 NOUN ct-9697 31 177 ; ; PUNCT ct-9697 31 178 prostaglandin prostaglandin NOUN ct-9697 31 179 - - PUNCT ct-9697 31 180 endoperoxide endoperoxide NOUN ct-9697 31 181 synthase synthase NOUN ct-9697 31 182 2 2 NUM ct-9697 31 183 / / SYM ct-9697 31 184 cyclooxygenase cyclooxygenase NOUN ct-9697 31 185 2 2 NUM ct-9697 31 186 rac rac NOUN ct-9697 31 187 ; ; PUNCT ct-9697 31 188 rac rac PROPN ct-9697 31 189 family family NOUN ct-9697 31 190 small small ADJ ct-9697 31 191 gtpase gtpase NOUN ct-9697 31 192 rln rln NOUN ct-9697 31 193 ; ; PUNCT ct-9697 31 194 relaxin relaxin PROPN ct-9697 31 195 s100a s100a PROPN ct-9697 31 196 ; ; PUNCT ct-9697 31 197 calgranulins calgranulins PROPN ct-9697 31 198 srd5a1 srd5a1 NOUN ct-9697 31 199 ; ; PUNCT ct-9697 31 200 5α 5α ADJ ct-9697 31 201 reductase reductase NOUN ct-9697 31 202 type type NOUN ct-9697 31 203 1 1 NUM ct-9697 31 204 tlr tlr PROPN ct-9697 31 205 ; ; PUNCT ct-9697 31 206 toll toll NOUN ct-9697 31 207 - - PUNCT ct-9697 31 208 like like ADJ ct-9697 31 209 receptors receptor NOUN ct-9697 31 210 tlra tlra ADJ ct-9697 31 211 ; ; PUNCT ct-9697 31 212 tlr tlr PROPN ct-9697 31 213 antagonists antagonist NOUN ct-9697 31 214 tlrs tlrs ADV ct-9697 31 215 ; ; PUNCT ct-9697 31 216 toll toll NOUN ct-9697 31 217 - - PUNCT ct-9697 31 218 like like ADJ ct-9697 31 219 receptors receptor NOUN ct-9697 31 220 tnfaip6 tnfaip6 NOUN ct-9697 31 221 ; ; PUNCT ct-9697 31 222 tnf tnf PROPN ct-9697 31 223 alpha alpha NOUN ct-9697 31 224 induced induce VERB ct-9697 31 225 protein protein NOUN ct-9697 31 226 6 6 NUM ct-9697 31 227 references reference NOUN ct-9697 31 228 1 1 NUM ct-9697 31 229 . . PUNCT ct-9697 32 1 el el PROPN ct-9697 32 2 - - PUNCT ct-9697 32 3 sheikh sheikh PROPN ct-9697 32 4 ali ali PROPN ct-9697 32 5 h h PROPN ct-9697 32 6 , , PUNCT ct-9697 32 7 legacki legacki PROPN ct-9697 32 8 el el PROPN ct-9697 32 9 , , PUNCT ct-9697 32 10 loux loux PROPN ct-9697 32 11 sc sc PROPN ct-9697 32 12 , , PUNCT ct-9697 32 13 et et PROPN ct-9697 32 14 al al PROPN ct-9697 32 15 : : PUNCT ct-9697 32 16 equine equine PROPN ct-9697 32 17 placentitis placentitis PROPN ct-9697 32 18 is be AUX ct-9697 32 19 associated associate VERB ct-9697 32 20 with with ADP ct-9697 32 21 a a DET ct-9697 32 22 downregulation downregulation NOUN ct-9697 32 23 in in ADP ct-9697 32 24 myometrial myometrial ADJ ct-9697 32 25 progestin progestin NOUN ct-9697 32 26 signaling signal VERB ct-9697 32 27 . . PUNCT ct-9697 33 1 biol biol PROPN ct-9697 33 2 reprod reprod PROPN ct-9697 33 3 2019;101:162 2019;101:162 PROPN ct-9697 33 4 - - SYM ct-9697 33 5 176 176 NUM ct-9697 33 6 . . PUNCT ct-9697 34 1 2 2 NUM ct-9697 34 2 . . X ct-9697 34 3 el el PROPN ct-9697 34 4 - - PUNCT ct-9697 34 5 sheikh sheikh PROPN ct-9697 34 6 ali ali PROPN ct-9697 34 7 h h PROPN ct-9697 34 8 , , PUNCT ct-9697 34 9 legacki legacki PROPN ct-9697 34 10 el el PROPN ct-9697 34 11 , , PUNCT ct-9697 34 12 loux loux PROPN ct-9697 34 13 sc sc PROPN ct-9697 34 14 , , PUNCT ct-9697 34 15 et et PROPN ct-9697 34 16 al al PROPN ct-9697 34 17 : : PUNCT ct-9697 34 18 transcriptomic transcriptomic ADJ ct-9697 34 19 analysis analysis NOUN ct-9697 34 20 reveals reveal VERB ct-9697 34 21 the the DET ct-9697 34 22 key key ADJ ct-9697 34 23 regulators regulator NOUN ct-9697 34 24 and and CCONJ ct-9697 34 25 molecular molecular ADJ ct-9697 34 26 mechanisms mechanism NOUN ct-9697 34 27 underlying underlie VERB ct-9697 34 28 myometrial myometrial ADJ ct-9697 34 29 activation activation NOUN ct-9697 34 30 during during ADP ct-9697 34 31 equine equine NOUN ct-9697 34 32 placentitis placentitis PROPN ct-9697 34 33 . . PUNCT ct-9697 35 1 biol biol PROPN ct-9697 35 2 reprod reprod PROPN ct-9697 35 3 2020 2020 NUM ct-9697 35 4 ; ; PUNCT ct-9697 35 5 in in ADP ct-9697 35 6 press press NOUN ct-9697 35 7 . . PUNCT ct-9697 36 1 3 3 X ct-9697 36 2 . . X ct-9697 36 3 el el PROPN ct-9697 36 4 - - PUNCT ct-9697 36 5 sheikh sheikh PROPN ct-9697 36 6 ali ali PROPN ct-9697 36 7 h h PROPN ct-9697 36 8 , , PUNCT ct-9697 36 9 legacki legacki PROPN ct-9697 36 10 el el PROPN ct-9697 36 11 , , PUNCT ct-9697 36 12 scoggin scoggin VERB ct-9697 36 13 ke ke PROPN ct-9697 36 14 , , PUNCT ct-9697 36 15 et et PROPN ct-9697 36 16 al al PROPN ct-9697 36 17 : : PUNCT ct-9697 36 18 steroid steroid NOUN ct-9697 36 19 synthesis synthesis NOUN ct-9697 36 20 and and CCONJ ct-9697 36 21 metabolism metabolism NOUN ct-9697 36 22 in in ADP ct-9697 36 23 the the DET ct-9697 36 24 equine equine NOUN ct-9697 36 25 placenta placenta NOUN ct-9697 36 26 during during ADP ct-9697 36 27 placentitis placentitis PROPN ct-9697 36 28 . . PUNCT ct-9697 37 1 reproduction reproduction NOUN ct-9697 37 2 2020;159:289 2020;159:289 NUM ct-9697 37 3 - - SYM ct-9697 37 4 302 302 NUM ct-9697 37 5 . . NOUN ct-9697 37 6 4 4 NUM ct-9697 37 7 . . PUNCT ct-9697 38 1 fernandes fernandes PROPN ct-9697 38 2 cb cb PROPN ct-9697 38 3 , , PUNCT ct-9697 38 4 ball ball PROPN ct-9697 38 5 ba ba PROPN ct-9697 38 6 , , PUNCT ct-9697 38 7 loux loux PROPN ct-9697 38 8 sc sc PROPN ct-9697 38 9 , , PUNCT ct-9697 38 10 et et PROPN ct-9697 38 11 al al PROPN ct-9697 38 12 : : PUNCT ct-9697 38 13 uterine uterine ADJ ct-9697 38 14 cervix cervix NOUN ct-9697 38 15 as as ADP ct-9697 38 16 a a DET ct-9697 38 17 fundamental fundamental ADJ ct-9697 38 18 part part NOUN ct-9697 38 19 of of ADP ct-9697 38 20 the the DET ct-9697 38 21 pathogenesis pathogenesis NOUN ct-9697 38 22 of of ADP ct-9697 38 23 pregnancy pregnancy NOUN ct-9697 38 24 loss loss NOUN ct-9697 38 25 associated associate VERB ct-9697 38 26 with with ADP ct-9697 38 27 ascending ascend VERB ct-9697 38 28 placentitis placentitis PROPN ct-9697 38 29 in in ADP ct-9697 38 30 mares mare NOUN ct-9697 38 31 . . PUNCT ct-9697 39 1 theriogenology theriogenology NOUN ct-9697 39 2 2019;45:167 2019;45:167 NUM ct-9697 39 3 - - SYM ct-9697 39 4 175 175 NUM ct-9697 39 5 . . PUNCT ct-9697 39 6 5 5 X ct-9697 39 7 . . X ct-9697 39 8 lyle lyle PROPN ct-9697 39 9 sk sk PROPN ct-9697 39 10 : : PUNCT ct-9697 39 11 immunology immunology NOUN ct-9697 39 12 of of ADP ct-9697 39 13 infective infective ADJ ct-9697 39 14 preterm preterm NOUN ct-9697 39 15 delivery delivery NOUN ct-9697 39 16 in in ADP ct-9697 39 17 the the DET ct-9697 39 18 mare mare NOUN ct-9697 39 19 . . PUNCT ct-9697 40 1 equine equine PROPN ct-9697 40 2 vet vet PROPN ct-9697 40 3 j j PROPN ct-9697 40 4 2014;46:661 2014;46:661 ADV ct-9697 40 5 - - PUNCT ct-9697 40 6 668 668 NUM ct-9697 40 7 . . NOUN ct-9697 40 8 6 6 NUM ct-9697 40 9 . . PUNCT ct-9697 41 1 wu wu PROPN ct-9697 41 2 s s PROPN ct-9697 41 3 - - PUNCT ct-9697 41 4 p p X ct-9697 41 5 , , PUNCT ct-9697 41 6 demayo demayo VERB ct-9697 41 7 fj fj PROPN ct-9697 41 8 : : PUNCT ct-9697 41 9 progesterone progesterone NOUN ct-9697 41 10 receptor receptor NOUN ct-9697 41 11 signaling signal VERB ct-9697 41 12 in in ADP ct-9697 41 13 uterine uterine ADJ ct-9697 41 14 myometrial myometrial ADJ ct-9697 41 15 physiology physiology NOUN ct-9697 41 16 and and CCONJ ct-9697 41 17 preterm preterm ADJ ct-9697 41 18 birth birth NOUN ct-9697 41 19 . . PUNCT ct-9697 42 1 in in ADP ct-9697 42 2 : : PUNCT ct-9697 42 3 forrest forrest PROPN ct-9697 42 4 d d PROPN ct-9697 42 5 , , PUNCT ct-9697 42 6 tsai tsai PROPN ct-9697 42 7 s s PART ct-9697 42 8 : : PUNCT ct-9697 42 9 editors editor NOUN ct-9697 42 10 . . PUNCT ct-9697 43 1 current current ADJ ct-9697 43 2 topics topic NOUN ct-9697 43 3 in in ADP ct-9697 43 4 developmental developmental ADJ ct-9697 43 5 biology biology NOUN ct-9697 43 6 . . PUNCT ct-9697 44 1 cambridge cambridge PROPN ct-9697 44 2 ; ; PUNCT ct-9697 44 3 academic academic ADJ ct-9697 44 4 press press NOUN ct-9697 44 5 , , PUNCT ct-9697 44 6 2017 2017 NUM ct-9697 44 7 : : PUNCT ct-9697 44 8 p. p. NOUN ct-9697 44 9 171 171 NUM ct-9697 44 10 - - SYM ct-9697 44 11 190 190 NUM ct-9697 44 12 . . PUNCT ct-9697 45 1 7 7 X ct-9697 45 2 . . PUNCT ct-9697 45 3 merlino merlino PROPN ct-9697 45 4 aa aa PROPN ct-9697 45 5 , , PUNCT ct-9697 45 6 welsh welsh PROPN ct-9697 45 7 tn tn PROPN ct-9697 45 8 , , PUNCT ct-9697 45 9 tan tan PROPN ct-9697 45 10 h h NOUN ct-9697 45 11 , , PUNCT ct-9697 45 12 et et PROPN ct-9697 45 13 al al PROPN ct-9697 45 14 : : PUNCT ct-9697 45 15 nuclear nuclear ADJ ct-9697 45 16 progesterone progesterone NOUN ct-9697 45 17 receptors receptor NOUN ct-9697 45 18 in in ADP ct-9697 45 19 the the DET ct-9697 45 20 human human ADJ ct-9697 45 21 pregnancy pregnancy NOUN ct-9697 45 22 myometrium myometrium NOUN ct-9697 45 23 : : PUNCT ct-9697 45 24 evidence evidence NOUN ct-9697 45 25 that that SCONJ ct-9697 45 26 parturition parturition NOUN ct-9697 45 27 involves involve VERB ct-9697 45 28 functional functional ADJ ct-9697 45 29 progesterone progesterone NOUN ct-9697 45 30 withdrawal withdrawal NOUN ct-9697 45 31 mediated mediate VERB ct-9697 45 32 by by ADP ct-9697 45 33 increased increase VERB ct-9697 45 34 expression expression NOUN ct-9697 45 35 of of ADP ct-9697 45 36 progesterone progesterone NOUN ct-9697 45 37 receptor receptor NOUN ct-9697 45 38 - - PUNCT ct-9697 45 39 a. a. NOUN ct-9697 45 40 j j PROPN ct-9697 45 41 clin clin PROPN ct-9697 45 42 endocrinol endocrinol VERB ct-9697 45 43 metab metab ADJ ct-9697 45 44 2007;92:1927 2007;92:1927 PROPN ct-9697 45 45 - - SYM ct-9697 45 46 1933 1933 NUM ct-9697 45 47 . . PUNCT ct-9697 46 1 8 8 X ct-9697 46 2 . . X ct-9697 46 3 mesiano mesiano PROPN ct-9697 46 4 s s PROPN ct-9697 46 5 , , PUNCT ct-9697 46 6 wang wang PROPN ct-9697 46 7 y y PROPN ct-9697 46 8 , , PUNCT ct-9697 46 9 norwitz norwitz PROPN ct-9697 46 10 er er INTJ ct-9697 46 11 : : PUNCT ct-9697 46 12 progesterone progesterone NOUN ct-9697 46 13 receptors receptor NOUN ct-9697 46 14 in in ADP ct-9697 46 15 the the DET ct-9697 46 16 human human ADJ ct-9697 46 17 pregnancy pregnancy NOUN ct-9697 46 18 uterus uterus NOUN ct-9697 46 19 : : PUNCT ct-9697 46 20 do do AUX ct-9697 46 21 they they PRON ct-9697 46 22 hold hold VERB ct-9697 46 23 the the DET ct-9697 46 24 key key NOUN ct-9697 46 25 to to ADP ct-9697 46 26 birth birth NOUN ct-9697 46 27 timing timing NOUN ct-9697 46 28 ? ? PUNCT ct-9697 47 1 reprod reprod PROPN ct-9697 47 2 sci sci PROPN ct-9697 47 3 2011;18:6 2011;18:6 NUM ct-9697 47 4 - - SYM ct-9697 47 5 19 19 NUM ct-9697 47 6 . . PUNCT ct-9697 47 7 clinical clinical ADJ ct-9697 47 8 theriogenology theriogenology NOUN ct-9697 47 9 • • NOUN ct-9697 47 10 volume volume NOUN ct-9697 47 11 12 12 NUM ct-9697 47 12 number number NOUN ct-9697 47 13 3 3 NUM ct-9697 47 14 • • NOUN ct-9697 47 15 september september PROPN ct-9697 47 16 2020344 2020344 NUM ct-9697 47 17 9 9 NUM ct-9697 47 18 . . PUNCT ct-9697 48 1 tan tan PROPN ct-9697 48 2 h h PROPN ct-9697 48 3 , , PUNCT ct-9697 48 4 yi yi PROPN ct-9697 48 5 l l NOUN ct-9697 48 6 , , PUNCT ct-9697 48 7 rote rote ADJ ct-9697 48 8 ns ns NUM ct-9697 48 9 , , PUNCT ct-9697 48 10 et et PROPN ct-9697 48 11 al al PROPN ct-9697 48 12 : : PUNCT ct-9697 48 13 progesterone progesterone NOUN ct-9697 48 14 receptor receptor NOUN ct-9697 48 15 - - PUNCT ct-9697 48 16 a a PRON ct-9697 48 17 and and CCONJ ct-9697 48 18 - - PUNCT ct-9697 48 19 b b NOUN ct-9697 48 20 have have VERB ct-9697 48 21 opposite opposite ADJ ct-9697 48 22 effects effect NOUN ct-9697 48 23 on on ADP ct-9697 48 24 proinflammatory proinflammatory ADJ ct-9697 48 25 gene gene NOUN ct-9697 48 26 expression expression NOUN ct-9697 48 27 in in ADP ct-9697 48 28 human human ADJ ct-9697 48 29 myometrial myometrial ADJ ct-9697 48 30 cells cell NOUN ct-9697 48 31 : : PUNCT ct-9697 48 32 implications implication NOUN ct-9697 48 33 for for ADP ct-9697 48 34 progesterone progesterone NOUN ct-9697 48 35 actions action NOUN ct-9697 48 36 in in ADP ct-9697 48 37 human human ADJ ct-9697 48 38 pregnancy pregnancy NOUN ct-9697 48 39 and and CCONJ ct-9697 48 40 parturition parturition NOUN ct-9697 48 41 . . PUNCT ct-9697 49 1 j j PROPN ct-9697 49 2 clin clin PROPN ct-9697 49 3 endocrinol endocrinol VERB ct-9697 49 4 metab metab PROPN ct-9697 49 5 2012;97 2012;97 NOUN ct-9697 49 6 : : PUNCT ct-9697 49 7 e719 e719 PROPN ct-9697 49 8 - - PUNCT ct-9697 49 9 e730 e730 NUM ct-9697 49 10 . . PUNCT ct-9697 50 1 10 10 NUM ct-9697 50 2 . . PUNCT ct-9697 51 1 chwalisz chwalisz PROPN ct-9697 51 2 k k PROPN ct-9697 51 3 , , PUNCT ct-9697 51 4 fahrenholz fahrenholz PROPN ct-9697 51 5 f f X ct-9697 51 6 , , PUNCT ct-9697 51 7 hackenberg hackenberg PROPN ct-9697 51 8 m m PROPN ct-9697 51 9 , , PUNCT ct-9697 51 10 et et PROPN ct-9697 51 11 al al PROPN ct-9697 51 12 : : PUNCT ct-9697 51 13 the the DET ct-9697 51 14 progesterone progesterone NOUN ct-9697 51 15 antagonist antagonist NOUN ct-9697 51 16 onapristone onapristone NOUN ct-9697 51 17 increases increase VERB ct-9697 51 18 the the DET ct-9697 51 19 effectiveness effectiveness NOUN ct-9697 51 20 of of ADP ct-9697 51 21 oxytocin oxytocin PROPN ct-9697 51 22 to to PART ct-9697 51 23 produce produce VERB ct-9697 51 24 delivery delivery NOUN ct-9697 51 25 without without ADP ct-9697 51 26 changing change VERB ct-9697 51 27 the the DET ct-9697 51 28 myometrial myometrial ADJ ct-9697 51 29 oxytocin oxytocin NOUN ct-9697 51 30 receptor receptor NOUN ct-9697 51 31 concentrations concentration NOUN ct-9697 51 32 . . PUNCT ct-9697 52 1 am be AUX ct-9697 52 2 j j PROPN ct-9697 52 3 obstet obstet PROPN ct-9697 52 4 gynecol.1991;165:1760 gynecol.1991;165:1760 PROPN ct-9697 52 5 - - PUNCT ct-9697 52 6 1770 1770 NUM ct-9697 52 7 . . PUNCT ct-9697 53 1 11 11 NUM ct-9697 53 2 . . PUNCT ct-9697 54 1 medzhitov medzhitov ADJ ct-9697 54 2 r r NOUN ct-9697 54 3 : : PUNCT ct-9697 54 4 toll toll NOUN ct-9697 54 5 - - PUNCT ct-9697 54 6 like like ADJ ct-9697 54 7 receptors receptor NOUN ct-9697 54 8 and and CCONJ ct-9697 54 9 innate innate ADJ ct-9697 54 10 immunity immunity NOUN ct-9697 54 11 . . PUNCT ct-9697 55 1 nat nat PROPN ct-9697 55 2 rev rev VERB ct-9697 55 3 immunol immunol NOUN ct-9697 55 4 2001;1:135 2001;1:135 PROPN ct-9697 55 5 - - SYM ct-9697 55 6 145 145 NUM ct-9697 55 7 . . PUNCT ct-9697 56 1 12 12 NUM ct-9697 56 2 . . PUNCT ct-9697 57 1 akira akira PROPN ct-9697 57 2 s s PROPN ct-9697 57 3 , , PUNCT ct-9697 57 4 takeda takeda X ct-9697 57 5 k k NOUN ct-9697 57 6 : : PUNCT ct-9697 57 7 toll toll NOUN ct-9697 57 8 - - PUNCT ct-9697 57 9 like like ADJ ct-9697 57 10 receptor receptor NOUN ct-9697 57 11 signalling signal VERB ct-9697 57 12 . . PUNCT ct-9697 58 1 nat nat PROPN ct-9697 58 2 rev rev VERB ct-9697 58 3 immunol immunol NOUN ct-9697 58 4 2004;4:499 2004;4:499 NOUN ct-9697 58 5 . . PUNCT ct-9697 59 1 13 13 NUM ct-9697 59 2 . . PUNCT ct-9697 59 3 adams adams PROPN ct-9697 59 4 waldorf waldorf PROPN ct-9697 59 5 km km PROPN ct-9697 59 6 , , PUNCT ct-9697 59 7 persing perse VERB ct-9697 59 8 d d PROPN ct-9697 59 9 , , PUNCT ct-9697 59 10 novy novy PROPN ct-9697 59 11 mj mj PROPN ct-9697 59 12 , , PUNCT ct-9697 59 13 et et PROPN ct-9697 59 14 al al PROPN ct-9697 59 15 : : PUNCT ct-9697 59 16 pretreatment pretreatment NOUN ct-9697 59 17 with with ADP ct-9697 59 18 toll toll NOUN ct-9697 59 19 - - PUNCT ct-9697 59 20 like like ADJ ct-9697 59 21 receptor receptor NOUN ct-9697 59 22 4 4 NUM ct-9697 59 23 antagonist antagonist NOUN ct-9697 59 24 inhibits inhibit VERB ct-9697 59 25 lipopolysaccharide lipopolysaccharide ADV ct-9697 59 26 - - PUNCT ct-9697 59 27 induced induce VERB ct-9697 59 28 preterm preterm NOUN ct-9697 59 29 uterine uterine ADJ ct-9697 59 30 contractility contractility NOUN ct-9697 59 31 , , PUNCT ct-9697 59 32 cytokines cytokine NOUN ct-9697 59 33 , , PUNCT ct-9697 59 34 and and CCONJ ct-9697 59 35 prostaglandins prostaglandin NOUN ct-9697 59 36 in in ADP ct-9697 59 37 rhesus rhesus NOUN ct-9697 59 38 monkeys monkey NOUN ct-9697 59 39 . . PUNCT ct-9697 60 1 reprod reprod PROPN ct-9697 60 2 sci sci PROPN ct-9697 60 3 2008;15:121 2008;15:121 PROPN ct-9697 60 4 - - PUNCT ct-9697 60 5 127 127 NUM ct-9697 60 6 . . PUNCT ct-9697 61 1 14 14 NUM ct-9697 61 2 . . PUNCT ct-9697 62 1 thomson thomson PROPN ct-9697 62 2 aj aj PROPN ct-9697 62 3 , , PUNCT ct-9697 62 4 telfer telfer PROPN ct-9697 62 5 jf jf PROPN ct-9697 62 6 , , PUNCT ct-9697 62 7 young young PROPN ct-9697 62 8 a a X ct-9697 62 9 , , PUNCT ct-9697 62 10 et et PROPN ct-9697 62 11 al al PROPN ct-9697 62 12 : : PUNCT ct-9697 62 13 leukocytes leukocyte NOUN ct-9697 62 14 infiltrate infiltrate VERB ct-9697 62 15 the the DET ct-9697 62 16 myometrium myometrium NOUN ct-9697 62 17 during during ADP ct-9697 62 18 human human ADJ ct-9697 62 19 parturition parturition NOUN ct-9697 62 20 : : PUNCT ct-9697 62 21 further further ADJ ct-9697 62 22 evidence evidence NOUN ct-9697 62 23 that that SCONJ ct-9697 62 24 labour labour NOUN ct-9697 62 25 is be AUX ct-9697 62 26 an an DET ct-9697 62 27 inflammatory inflammatory ADJ ct-9697 62 28 process process NOUN ct-9697 62 29 . . PUNCT ct-9697 63 1 hum hum PROPN ct-9697 63 2 reprod reprod PROPN ct-9697 63 3 1999;14:229 1999;14:229 PROPN ct-9697 63 4 - - PUNCT ct-9697 63 5 236 236 NUM ct-9697 63 6 . . NOUN ct-9697 64 1 15 15 NUM ct-9697 64 2 . . PUNCT ct-9697 65 1 shynlova shynlova PROPN ct-9697 66 1 o o NOUN ct-9697 66 2 , , PUNCT ct-9697 66 3 nedd nedd PROPN ct-9697 66 4 - - PUNCT ct-9697 66 5 roderique roderique PROPN ct-9697 66 6 t t PROPN ct-9697 66 7 , , PUNCT ct-9697 66 8 li li PROPN ct-9697 66 9 y y PROPN ct-9697 66 10 , , PUNCT ct-9697 66 11 et et PROPN ct-9697 66 12 al al PROPN ct-9697 66 13 : : PUNCT ct-9697 66 14 myometrial myometrial ADJ ct-9697 66 15 immune immune ADJ ct-9697 66 16 cells cell NOUN ct-9697 66 17 contribute contribute VERB ct-9697 66 18 to to ADP ct-9697 66 19 term term NOUN ct-9697 66 20 parturition parturition NOUN ct-9697 66 21 , , PUNCT ct-9697 66 22 preterm preterm ADJ ct-9697 66 23 labour labour NOUN ct-9697 66 24 and and CCONJ ct-9697 66 25 post post ADJ ct-9697 66 26 - - ADJ ct-9697 66 27 partum partum ADJ ct-9697 66 28 involution involution NOUN ct-9697 66 29 in in ADP ct-9697 66 30 mice mouse NOUN ct-9697 66 31 . . PUNCT ct-9697 67 1 j j PROPN ct-9697 67 2 cell cell PROPN ct-9697 67 3 mol mol ADP ct-9697 67 4 med med PROPN ct-9697 67 5 2013;17:90 2013;17:90 NUM ct-9697 67 6 - - SYM ct-9697 67 7 102 102 NUM ct-9697 67 8 . . PUNCT ct-9697 67 9 16 16 NUM ct-9697 67 10 . . PUNCT ct-9697 68 1 mackler mackler NOUN ct-9697 68 2 am am PROPN ct-9697 68 3 , , PUNCT ct-9697 68 4 green green PROPN ct-9697 68 5 lm lm PROPN ct-9697 68 6 , , PUNCT ct-9697 68 7 mcmillan mcmillan PROPN ct-9697 68 8 pj pj PROPN ct-9697 68 9 , , PUNCT ct-9697 68 10 et et PROPN ct-9697 68 11 al al PROPN ct-9697 68 12 : : PUNCT ct-9697 68 13 distribution distribution NOUN ct-9697 68 14 and and CCONJ ct-9697 68 15 activation activation NOUN ct-9697 68 16 of of ADP ct-9697 68 17 uterine uterine ADJ ct-9697 68 18 mononuclear mononuclear ADJ ct-9697 68 19 phagocytes phagocyte NOUN ct-9697 68 20 in in ADP ct-9697 68 21 peripartum peripartum NOUN ct-9697 68 22 endometrium endometrium NOUN ct-9697 68 23 and and CCONJ ct-9697 68 24 myometrium myometrium NOUN ct-9697 68 25 of of ADP ct-9697 68 26 the the DET ct-9697 68 27 mouse mouse NOUN ct-9697 68 28 . . PUNCT ct-9697 69 1 biol biol PROPN ct-9697 69 2 reprod reprod PROPN ct-9697 69 3 2000;62:1193 2000;62:1193 PROPN ct-9697 69 4 - - SYM ct-9697 69 5 1200 1200 NUM ct-9697 69 6 . . PUNCT ct-9697 70 1 17 17 NUM ct-9697 70 2 . . PUNCT ct-9697 71 1 lirussi lirussi PROPN ct-9697 71 2 f f PROPN ct-9697 71 3 , , PUNCT ct-9697 71 4 rakotoniaina rakotoniaina PROPN ct-9697 71 5 z z PROPN ct-9697 71 6 , , PUNCT ct-9697 71 7 madani madani PROPN ct-9697 71 8 s s PROPN ct-9697 71 9 , , PUNCT ct-9697 71 10 et et PROPN ct-9697 71 11 al al PROPN ct-9697 71 12 : : PUNCT ct-9697 71 13 adrb3 adrb3 ADJ ct-9697 71 14 adrenergic adrenergic ADJ ct-9697 71 15 receptor receptor NOUN ct-9697 71 16 is be AUX ct-9697 71 17 a a DET ct-9697 71 18 key key ADJ ct-9697 71 19 regulator regulator NOUN ct-9697 71 20 of of ADP ct-9697 71 21 human human ADJ ct-9697 71 22 myometrial myometrial ADJ ct-9697 71 23 apoptosis apoptosis NOUN ct-9697 71 24 and and CCONJ ct-9697 71 25 inflammation inflammation NOUN ct-9697 71 26 during during ADP ct-9697 71 27 chorioamnionitis chorioamnionitis PROPN ct-9697 71 28 . . PUNCT ct-9697 72 1 biol biol PROPN ct-9697 72 2 reprod reprod PROPN ct-9697 72 3 2008;78:497 2008;78:497 PROPN ct-9697 72 4 - - SYM ct-9697 72 5 505 505 NUM ct-9697 72 6 . . PUNCT ct-9697 72 7 18 18 NUM ct-9697 72 8 . . PUNCT ct-9697 73 1 leroy leroy PROPN ct-9697 73 2 m m PROPN ct-9697 73 3 - - PROPN ct-9697 73 4 j j PROPN ct-9697 73 5 , , PUNCT ct-9697 73 6 dallot dallot NOUN ct-9697 73 7 e e NOUN ct-9697 73 8 , , PUNCT ct-9697 73 9 czerkiewicz czerkiewicz VERB ct-9697 73 10 i i PRON ct-9697 73 11 , , PUNCT ct-9697 73 12 et et PROPN ct-9697 73 13 al al PROPN ct-9697 73 14 : : PUNCT ct-9697 73 15 inflammation inflammation NOUN ct-9697 73 16 of of ADP ct-9697 73 17 choriodecidua choriodecidua PROPN ct-9697 73 18 induces induce VERB ct-9697 73 19 tumor tumor NOUN ct-9697 73 20 necrosis necrosis NOUN ct-9697 73 21 factor factor NOUN ct-9697 73 22 alpha alpha NOUN ct-9697 73 23 - - PUNCT ct-9697 73 24 mediated mediate VERB ct-9697 73 25 apoptosis apoptosis NOUN ct-9697 73 26 of of ADP ct-9697 73 27 human human ADJ ct-9697 73 28 myometrial myometrial ADJ ct-9697 73 29 cells1 cells1 NOUN ct-9697 73 30 . . PUNCT ct-9697 74 1 biol biol PROPN ct-9697 74 2 reprod reprod PROPN ct-9697 74 3 2007;76:769 2007;76:769 PROPN ct-9697 74 4 - - PUNCT ct-9697 74 5 776 776 NUM ct-9697 74 6 . . NOUN ct-9697 74 7 19 19 NUM ct-9697 74 8 . . PUNCT ct-9697 74 9 muhle muhle PROPN ct-9697 74 10 ra ra PROPN ct-9697 74 11 , , PUNCT ct-9697 74 12 pavlidis pavlidi NOUN ct-9697 74 13 p p X ct-9697 74 14 , , PUNCT ct-9697 74 15 grundy grundy PROPN ct-9697 74 16 wn wn PROPN ct-9697 74 17 , , PUNCT ct-9697 74 18 et et PROPN ct-9697 74 19 al al PROPN ct-9697 74 20 : : PUNCT ct-9697 74 21 a a DET ct-9697 74 22 high high ADJ ct-9697 74 23 - - PUNCT ct-9697 74 24 throughput throughput NOUN ct-9697 74 25 study study NOUN ct-9697 74 26 of of ADP ct-9697 74 27 gene gene NOUN ct-9697 74 28 expression expression NOUN ct-9697 74 29 in in ADP ct-9697 74 30 preterm preterm ADJ ct-9697 74 31 labor labor NOUN ct-9697 74 32 with with ADP ct-9697 74 33 a a DET ct-9697 74 34 subtractive subtractive NOUN ct-9697 74 35 microarray microarray NOUN ct-9697 74 36 approach approach NOUN ct-9697 74 37 . . PUNCT ct-9697 75 1 am be AUX ct-9697 75 2 j j PROPN ct-9697 75 3 obstet obstet PROPN ct-9697 75 4 gynecol gynecol PROPN ct-9697 75 5 2001;185:716 2001;185:716 PROPN ct-9697 75 6 - - SYM ct-9697 75 7 724 724 NUM ct-9697 75 8 . . PUNCT ct-9697 76 1 20 20 NUM ct-9697 76 2 . . PUNCT ct-9697 77 1 shynlova shynlova PROPN ct-9697 78 1 o o NOUN ct-9697 78 2 , , PUNCT ct-9697 78 3 oldenhof oldenhof ADV ct-9697 78 4 a a PRON ct-9697 78 5 , , PUNCT ct-9697 78 6 dorogin dorogin NOUN ct-9697 78 7 a a X ct-9697 78 8 , , PUNCT ct-9697 78 9 et et PROPN ct-9697 78 10 al al PROPN ct-9697 78 11 : : PUNCT ct-9697 78 12 myometrial myometrial ADJ ct-9697 78 13 apoptosis apoptosis NOUN ct-9697 78 14 : : PUNCT ct-9697 78 15 activation activation NOUN ct-9697 78 16 of of ADP ct-9697 78 17 the the DET ct-9697 78 18 caspase caspase NOUN ct-9697 78 19 cascade cascade NOUN ct-9697 78 20 in in ADP ct-9697 78 21 the the DET ct-9697 78 22 pregnant pregnant ADJ ct-9697 78 23 rat rat NOUN ct-9697 78 24 myometrium myometrium NOUN ct-9697 78 25 at at ADP ct-9697 78 26 midgestation midgestation NOUN ct-9697 78 27 . . PUNCT ct-9697 79 1 biol biol PROPN ct-9697 79 2 reprod reprod PROPN ct-9697 79 3 2006;74:839 2006;74:839 PROPN ct-9697 79 4 - - SYM ct-9697 79 5 849 849 NUM ct-9697 79 6 . . PUNCT ct-9697 79 7 21 21 NUM ct-9697 79 8 . . PUNCT ct-9697 80 1 arthur arthur PROPN ct-9697 80 2 p p PROPN ct-9697 80 3 , , PUNCT ct-9697 80 4 taggart taggart PROPN ct-9697 80 5 mj mj PROPN ct-9697 80 6 , , PUNCT ct-9697 80 7 zielnik zielnik PROPN ct-9697 80 8 b b X ct-9697 80 9 , , PUNCT ct-9697 80 10 et et PROPN ct-9697 80 11 al al PROPN ct-9697 80 12 : : PUNCT ct-9697 80 13 relationship relationship NOUN ct-9697 80 14 between between ADP ct-9697 80 15 gene gene NOUN ct-9697 80 16 expression expression NOUN ct-9697 80 17 and and CCONJ ct-9697 80 18 function function NOUN ct-9697 80 19 of of ADP ct-9697 80 20 uterotonic uterotonic ADJ ct-9697 80 21 systems system NOUN ct-9697 80 22 in in ADP ct-9697 80 23 the the DET ct-9697 80 24 rat rat NOUN ct-9697 80 25 during during ADP ct-9697 80 26 gestation gestation NOUN ct-9697 80 27 , , PUNCT ct-9697 80 28 uterine uterine ADJ ct-9697 80 29 activation activation NOUN ct-9697 80 30 and and CCONJ ct-9697 80 31 both both DET ct-9697 80 32 term term NOUN ct-9697 80 33 and and CCONJ ct-9697 80 34 preterm preterm ADJ ct-9697 80 35 labour labour NOUN ct-9697 80 36 . . PUNCT ct-9697 81 1 j j PROPN ct-9697 81 2 physiol physiol PROPN ct-9697 81 3 2008;586:6063 2008;586:6063 NUM ct-9697 81 4 - - SYM ct-9697 81 5 6076 6076 NUM ct-9697 81 6 . . PUNCT ct-9697 82 1 22 22 NUM ct-9697 82 2 . . PUNCT ct-9697 83 1 sakai sakai PROPN ct-9697 83 2 n n PROPN ct-9697 83 3 , , PUNCT ct-9697 83 4 tabb tabb PROPN ct-9697 83 5 t t PROPN ct-9697 83 6 , , PUNCT ct-9697 83 7 garfield garfield PROPN ct-9697 83 8 re re PROPN ct-9697 83 9 : : PUNCT ct-9697 83 10 modulation modulation NOUN ct-9697 83 11 of of ADP ct-9697 83 12 cell cell NOUN ct-9697 83 13 - - PUNCT ct-9697 83 14 to to ADP ct-9697 83 15 - - PUNCT ct-9697 83 16 cell cell NOUN ct-9697 83 17 coupling coupling NOUN ct-9697 83 18 between between ADP ct-9697 83 19 myometrial myometrial ADJ ct-9697 83 20 cells cell NOUN ct-9697 83 21 of of ADP ct-9697 83 22 the the DET ct-9697 83 23 human human ADJ ct-9697 83 24 uterus uterus NOUN ct-9697 83 25 during during ADP ct-9697 83 26 pregnancy pregnancy NOUN ct-9697 83 27 . . PUNCT ct-9697 84 1 am be AUX ct-9697 84 2 j j PROPN ct-9697 84 3 obstet obstet PROPN ct-9697 84 4 gynec gynec PROPN ct-9697 84 5 1992;167:472 1992;167:472 PROPN ct-9697 84 6 - - PUNCT ct-9697 84 7 480 480 NUM ct-9697 84 8 . . PUNCT ct-9697 85 1 23 23 NUM ct-9697 85 2 . . PUNCT ct-9697 86 1 balducci balducci PROPN ct-9697 86 2 j j PROPN ct-9697 86 3 , , PUNCT ct-9697 86 4 risek risek PROPN ct-9697 86 5 b b PROPN ct-9697 86 6 , , PUNCT ct-9697 86 7 gilula gilula NOUN ct-9697 86 8 nb nb PROPN ct-9697 86 9 , , PUNCT ct-9697 86 10 et et PROPN ct-9697 86 11 al al PROPN ct-9697 86 12 : : PUNCT ct-9697 86 13 gap gap NOUN ct-9697 86 14 junction junction NOUN ct-9697 86 15 formation formation NOUN ct-9697 86 16 in in ADP ct-9697 86 17 human human ADJ ct-9697 86 18 myometrium myometrium NOUN ct-9697 86 19 : : PUNCT ct-9697 86 20 a a DET ct-9697 86 21 key key NOUN ct-9697 86 22 to to ADP ct-9697 86 23 preterm preterm ADJ ct-9697 86 24 labor labor NOUN ct-9697 86 25 ? ? PUNCT ct-9697 86 26 am be AUX ct-9697 86 27 j j PROPN ct-9697 86 28 obstet obstet PROPN ct-9697 86 29 gynec gynec PROPN ct-9697 86 30 1993;168:1609 1993;168:1609 PROPN ct-9697 86 31 - - SYM ct-9697 86 32 1615 1615 NUM ct-9697 86 33 . . PUNCT ct-9697 87 1 24 24 NUM ct-9697 87 2 . . PUNCT ct-9697 88 1 cook cook VERB ct-9697 88 2 jl jl PROPN ct-9697 88 3 , , PUNCT ct-9697 88 4 zaragoza zaragoza PROPN ct-9697 88 5 db db PROPN ct-9697 88 6 , , PUNCT ct-9697 88 7 sung sing VERB ct-9697 88 8 dh dh PROPN ct-9697 88 9 , , PUNCT ct-9697 88 10 et et PROPN ct-9697 88 11 al al PROPN ct-9697 88 12 : : PUNCT ct-9697 88 13 expression expression NOUN ct-9697 88 14 of of ADP ct-9697 88 15 myometrial myometrial ADJ ct-9697 88 16 activation activation NOUN ct-9697 88 17 and and CCONJ ct-9697 88 18 stimulation stimulation NOUN ct-9697 88 19 genes gene NOUN ct-9697 88 20 in in ADP ct-9697 88 21 a a DET ct-9697 88 22 mouse mouse NOUN ct-9697 88 23 model model NOUN ct-9697 88 24 of of ADP ct-9697 88 25 preterm preterm ADJ ct-9697 88 26 labor labor NOUN ct-9697 88 27 : : PUNCT ct-9697 88 28 myometrial myometrial ADJ ct-9697 88 29 activation activation NOUN ct-9697 88 30 , , PUNCT ct-9697 88 31 stimulation stimulation NOUN ct-9697 88 32 , , PUNCT ct-9697 88 33 and and CCONJ ct-9697 88 34 preterm preterm ADJ ct-9697 88 35 labor labor NOUN ct-9697 88 36 . . PUNCT ct-9697 89 1 endocrinology endocrinology NOUN ct-9697 89 2 2000;141:1718 2000;141:1718 PROPN ct-9697 89 3 - - SYM ct-9697 89 4 1728 1728 NUM ct-9697 89 5 . . PUNCT ct-9697 90 1 25 25 NUM ct-9697 90 2 . . PUNCT ct-9697 90 3 mahendroo mahendroo PROPN ct-9697 90 4 m m VERB ct-9697 90 5 : : PUNCT ct-9697 90 6 cervical cervical ADJ ct-9697 90 7 remodeling remodeling NOUN ct-9697 90 8 in in ADP ct-9697 90 9 term term NOUN ct-9697 90 10 and and CCONJ ct-9697 90 11 preterm preterm ADJ ct-9697 90 12 birth birth NOUN ct-9697 90 13 : : PUNCT ct-9697 90 14 insights insight NOUN ct-9697 90 15 from from ADP ct-9697 90 16 an an DET ct-9697 90 17 animal animal NOUN ct-9697 90 18 model model NOUN ct-9697 90 19 . . PUNCT ct-9697 91 1 reproduction reproduction NOUN ct-9697 91 2 2012;143:429 2012;143:429 NUM ct-9697 91 3 - - SYM ct-9697 91 4 438 438 NUM ct-9697 91 5 . . PUNCT ct-9697 91 6 26 26 NUM ct-9697 91 7 . . PUNCT ct-9697 92 1 liggins liggin NOUN ct-9697 92 2 g g NOUN ct-9697 92 3 : : PUNCT ct-9697 92 4 the the DET ct-9697 92 5 cervix cervix NOUN ct-9697 92 6 in in ADP ct-9697 92 7 pregnancy pregnancy NOUN ct-9697 92 8 and and CCONJ ct-9697 92 9 labor labor NOUN ct-9697 92 10 , , PUNCT ct-9697 92 11 clinical clinical ADJ ct-9697 92 12 and and CCONJ ct-9697 92 13 biochemical biochemical ADJ ct-9697 92 14 investigation investigation NOUN ct-9697 92 15 . . PUNCT ct-9697 93 1 edinburgh edinburgh PROPN ct-9697 93 2 . . PROPN ct-9697 93 3 cuurchill cuurchill PROPN ct-9697 93 4 livingrtone.1981:1 livingrtone.1981:1 PROPN ct-9697 93 5 - - NOUN ct-9697 93 6 9 9 NUM ct-9697 93 7 . . NOUN ct-9697 94 1 27 27 NUM ct-9697 94 2 . . PUNCT ct-9697 95 1 leppert leppert PROPN ct-9697 95 2 pc pc PROPN ct-9697 95 3 : : PUNCT ct-9697 95 4 anatomy anatomy NOUN ct-9697 95 5 and and CCONJ ct-9697 95 6 physiology physiology NOUN ct-9697 95 7 of of ADP ct-9697 95 8 cervical cervical ADJ ct-9697 95 9 ripening ripening NOUN ct-9697 95 10 . . PUNCT ct-9697 96 1 clin clin PROPN ct-9697 96 2 obstet obstet NOUN ct-9697 96 3 gynecol gynecol PROPN ct-9697 96 4 1995;38:267 1995;38:267 PROPN ct-9697 96 5 - - SYM ct-9697 96 6 279 279 NUM ct-9697 96 7 . . PUNCT ct-9697 97 1 28 28 NUM ct-9697 97 2 . . PUNCT ct-9697 98 1 read read VERB ct-9697 98 2 cp cp PROPN ct-9697 98 3 , , PUNCT ct-9697 98 4 word word NOUN ct-9697 98 5 ra ra PROPN ct-9697 98 6 , , PUNCT ct-9697 98 7 ruscheinsky ruscheinsky PROPN ct-9697 98 8 ma ma PROPN ct-9697 98 9 , , PUNCT ct-9697 98 10 et et PROPN ct-9697 98 11 al al PROPN ct-9697 98 12 : : PUNCT ct-9697 98 13 cervical cervical ADJ ct-9697 98 14 remodeling remodeling NOUN ct-9697 98 15 during during ADP ct-9697 98 16 pregnancy pregnancy NOUN ct-9697 98 17 and and CCONJ ct-9697 98 18 parturition parturition NOUN ct-9697 98 19 : : PUNCT ct-9697 98 20 molecular molecular ADJ ct-9697 98 21 characterization characterization NOUN ct-9697 98 22 of of ADP ct-9697 98 23 the the DET ct-9697 98 24 softening soften VERB ct-9697 98 25 phase phase NOUN ct-9697 98 26 in in ADP ct-9697 98 27 mice mouse NOUN ct-9697 98 28 . . PUNCT ct-9697 99 1 reproduction reproduction NOUN ct-9697 99 2 2007;134:327 2007;134:327 NUM ct-9697 99 3 - - SYM ct-9697 99 4 340 340 NUM ct-9697 99 5 . . PUNCT ct-9697 99 6 29 29 NUM ct-9697 99 7 . . PUNCT ct-9697 100 1 el el PROPN ct-9697 100 2 - - PUNCT ct-9697 100 3 sheikh sheikh PROPN ct-9697 100 4 ali ali PROPN ct-9697 100 5 h h PROPN ct-9697 100 6 , , PUNCT ct-9697 100 7 legacki legacki PROPN ct-9697 100 8 el el PROPN ct-9697 100 9 , , PUNCT ct-9697 100 10 loux loux PROPN ct-9697 100 11 sc sc PROPN ct-9697 100 12 , , PUNCT ct-9697 100 13 et et PROPN ct-9697 100 14 al al PROPN ct-9697 100 15 : : PUNCT ct-9697 100 16 transcriptome transcriptome ADJ ct-9697 100 17 analysis analysis NOUN ct-9697 100 18 reveals reveal VERB ct-9697 100 19 the the DET ct-9697 100 20 key key ADJ ct-9697 100 21 regulators regulator NOUN ct-9697 100 22 and and CCONJ ct-9697 100 23 molecular molecular ADJ ct-9697 100 24 mechanisms mechanism NOUN ct-9697 100 25 underlying underlie VERB ct-9697 100 26 equine equine NOUN ct-9697 100 27 cervix cervix NOUN ct-9697 100 28 remodeling remodeling NOUN ct-9697 100 29 during during ADP ct-9697 100 30 placentitis placentitis PROPN ct-9697 100 31 and and CCONJ ct-9697 100 32 prepartum prepartum NOUN ct-9697 100 33 period period NOUN ct-9697 100 34 . . PUNCT ct-9697 101 1 proc proc NOUN ct-9697 101 2 annu annu PROPN ct-9697 101 3 conf conf NOUN ct-9697 101 4 plant plant NOUN ct-9697 101 5 anim anim NOUN ct-9697 101 6 genome genome NOUN ct-9697 101 7 2019 2019 NUM ct-9697 101 8 ; ; PUNCT ct-9697 102 1 po0311 po0311 ADJ ct-9697 102 2 . . PUNCT ct-9697 103 1 clinical clinical ADJ ct-9697 103 2 theriogenology theriogenology NOUN ct-9697 103 3 • • NOUN ct-9697 103 4 volume volume NOUN ct-9697 103 5 12 12 NUM ct-9697 103 6 number number NOUN ct-9697 103 7 3 3 NUM ct-9697 103 8 • • NUM ct-9697 103 9 september september PROPN ct-9697 103 10 2020 2020 NUM ct-9697 103 11 345 345 NUM ct-9697 103 12 024_ms-024 024_ms-024 PUNCT ct-9697 104 1 el el ADJ ct-9697 104 2 - - PUNCT ct-9697 104 3 sheikh sheikh NOUN