id sid tid token lemma pos ct-9916 1 1 1 1 NUM ct-9916 1 2 contact contact NOUN ct-9916 1 3 julie julie PROPN ct-9916 1 4 cecere cecere PROPN ct-9916 1 5 juliet@vt.edu juliet@vt.edu PROPN ct-9916 1 6 © © PROPN ct-9916 1 7 2023 2023 NUM ct-9916 1 8 the the DET ct-9916 1 9 author(s author(s NOUN ct-9916 1 10 ) ) PUNCT ct-9916 1 11 . . PUNCT ct-9916 2 1 this this PRON ct-9916 2 2 is be AUX ct-9916 2 3 an an DET ct-9916 2 4 open open ADJ ct-9916 2 5 access access NOUN ct-9916 2 6 article article NOUN ct-9916 2 7 distributed distribute VERB ct-9916 2 8 under under ADP ct-9916 2 9 the the DET ct-9916 2 10 terms term NOUN ct-9916 2 11 of of ADP ct-9916 2 12 the the DET ct-9916 2 13 creative creative ADJ ct-9916 2 14 commons common NOUN ct-9916 2 15 attribution attribution NOUN ct-9916 2 16 - - PUNCT ct-9916 2 17 noncommercial noncommercial ADJ ct-9916 2 18 4.0 4.0 NUM ct-9916 2 19 international international ADJ ct-9916 2 20 license license NOUN ct-9916 2 21 ( ( PUNCT ct-9916 2 22 http:// http:// PROPN ct-9916 2 23 creativecommons.org/licenses/by-nc/4.0/ creativecommons.org/licenses/by-nc/4.0/ NOUN ct-9916 2 24 ) ) PUNCT ct-9916 2 25 , , PUNCT ct-9916 2 26 permitting permit VERB ct-9916 2 27 all all DET ct-9916 2 28 non non ADJ ct-9916 2 29 - - ADJ ct-9916 2 30 commercial commercial ADJ ct-9916 2 31 use use NOUN ct-9916 2 32 , , PUNCT ct-9916 2 33 distribution distribution NOUN ct-9916 2 34 , , PUNCT ct-9916 2 35 and and CCONJ ct-9916 2 36 reproduction reproduction NOUN ct-9916 2 37 in in ADP ct-9916 2 38 any any DET ct-9916 2 39 medium medium NOUN ct-9916 2 40 , , PUNCT ct-9916 2 41 provided provide VERB ct-9916 2 42 the the DET ct-9916 2 43 original original ADJ ct-9916 2 44 work work NOUN ct-9916 2 45 is be AUX ct-9916 2 46 properly properly ADV ct-9916 2 47 cited cite VERB ct-9916 2 48 . . PUNCT ct-9916 3 1 citation citation NOUN ct-9916 3 2 line line NOUN ct-9916 3 3 : : PUNCT ct-9916 3 4 clinical clinical ADJ ct-9916 3 5 theriogenology theriogenology NOUN ct-9916 3 6 2023 2023 NUM ct-9916 3 7 , , PUNCT ct-9916 3 8 15 15 NUM ct-9916 3 9 , , PUNCT ct-9916 3 10 9916 9916 NUM ct-9916 3 11 , , PUNCT ct-9916 3 12 http://dx.doi.org/10.58292/ct.v15.9916 http://dx.doi.org/10.58292/ct.v15.9916 PROPN ct-9916 3 13 review review NOUN ct-9916 3 14 report report NOUN ct-9916 3 15 hypothyroidism hypothyroidism NOUN ct-9916 3 16 in in ADP ct-9916 3 17 canine canine PROPN ct-9916 3 18 reproduction† reproduction† NOUN ct-9916 3 19 julie julie PROPN ct-9916 3 20 cecere cecere PROPN ct-9916 3 21 department department PROPN ct-9916 3 22 of of ADP ct-9916 3 23 small small ADJ ct-9916 3 24 animal animal NOUN ct-9916 3 25 clinical clinical ADJ ct-9916 3 26 sciences science NOUN ct-9916 3 27 , , PUNCT ct-9916 3 28 virginia virginia PROPN ct-9916 3 29 - - PUNCT ct-9916 3 30 maryland maryland PROPN ct-9916 3 31 college college NOUN ct-9916 3 32 of of ADP ct-9916 3 33 veterinary veterinary ADJ ct-9916 3 34 medicine medicine NOUN ct-9916 3 35 , , PUNCT ct-9916 3 36 blacksburg blacksburg PROPN ct-9916 3 37 , , PUNCT ct-9916 3 38 va va PROPN ct-9916 3 39 , , PUNCT ct-9916 3 40 usa usa PROPN ct-9916 3 41 abstract abstract ADJ ct-9916 3 42 hypothyroidism hypothyroidism NOUN ct-9916 3 43 is be AUX ct-9916 3 44 one one NUM ct-9916 3 45 of of ADP ct-9916 3 46 the the DET ct-9916 3 47 most most ADV ct-9916 3 48 commonly commonly ADV ct-9916 3 49 diagnosed diagnose VERB ct-9916 3 50 endocrine endocrine NOUN ct-9916 3 51 diseases disease NOUN ct-9916 3 52 in in ADP ct-9916 3 53 dogs dog NOUN ct-9916 3 54 . . PUNCT ct-9916 4 1 it it PRON ct-9916 4 2 has have AUX ct-9916 4 3 been be AUX ct-9916 4 4 implicated implicate VERB ct-9916 4 5 for for ADP ct-9916 4 6 many many ADJ ct-9916 4 7 reproductive reproductive ADJ ct-9916 4 8 difficulties difficulty NOUN ct-9916 4 9 in in ADP ct-9916 4 10 breeding breed VERB ct-9916 4 11 dogs dog NOUN ct-9916 4 12 ; ; PUNCT ct-9916 4 13 however however ADV ct-9916 4 14 , , PUNCT ct-9916 4 15 only only ADV ct-9916 4 16 a a DET ct-9916 4 17 few few ADJ ct-9916 4 18 studies study NOUN ct-9916 4 19 have have AUX ct-9916 4 20 investigated investigate VERB ct-9916 4 21 the the DET ct-9916 4 22 involvement involvement NOUN ct-9916 4 23 of of ADP ct-9916 4 24 thyroid thyroid NOUN ct-9916 4 25 hormones hormone NOUN ct-9916 4 26 in in ADP ct-9916 4 27 reproduction reproduction NOUN ct-9916 4 28 . . PUNCT ct-9916 5 1 due due ADP ct-9916 5 2 to to ADP ct-9916 5 3 intricacies intricacy NOUN ct-9916 5 4 related relate VERB ct-9916 5 5 to to ADP ct-9916 5 6 appropriate appropriate ADJ ct-9916 5 7 testing testing NOUN ct-9916 5 8 , , PUNCT ct-9916 5 9 breeding breeding NOUN ct-9916 5 10 animals animal NOUN ct-9916 5 11 may may AUX ct-9916 5 12 be be AUX ct-9916 5 13 placed place VERB ct-9916 5 14 on on ADP ct-9916 5 15 thyroid thyroid NOUN ct-9916 5 16 supplementation supplementation NOUN ct-9916 5 17 without without ADP ct-9916 5 18 justification justification NOUN ct-9916 5 19 . . PUNCT ct-9916 6 1 the the DET ct-9916 6 2 disease disease NOUN ct-9916 6 3 , , PUNCT ct-9916 6 4 testing testing NOUN ct-9916 6 5 , , PUNCT ct-9916 6 6 heritability heritability NOUN ct-9916 6 7 , , PUNCT ct-9916 6 8 and and CCONJ ct-9916 6 9 animals animal NOUN ct-9916 6 10 that that PRON ct-9916 6 11 may may AUX ct-9916 6 12 need need VERB ct-9916 6 13 supplementation supplementation NOUN ct-9916 6 14 are be AUX ct-9916 6 15 discussed discuss VERB ct-9916 6 16 . . PUNCT ct-9916 7 1 additionally additionally ADV ct-9916 7 2 , , PUNCT ct-9916 7 3 the the DET ct-9916 7 4 assumption assumption NOUN ct-9916 7 5 / / SYM ct-9916 7 6 appropriateness appropriateness NOUN ct-9916 7 7 of of ADP ct-9916 7 8 breeding breeding NOUN ct-9916 7 9 animals animal NOUN ct-9916 7 10 that that PRON ct-9916 7 11 are be AUX ct-9916 7 12 truly truly ADV ct-9916 7 13 hypothyroid hypothyroid ADJ ct-9916 7 14 is be AUX ct-9916 7 15 questioned question VERB ct-9916 7 16 . . PUNCT ct-9916 8 1 keywords keyword NOUN ct-9916 8 2 : : PUNCT ct-9916 8 3 hypothyroid hypothyroid ADJ ct-9916 8 4 , , PUNCT ct-9916 8 5 reproduction reproduction NOUN ct-9916 8 6 , , PUNCT ct-9916 8 7 endocrine endocrine NOUN ct-9916 8 8 , , PUNCT ct-9916 8 9 infertility infertility NOUN ct-9916 8 10 pathophysiology pathophysiology NOUN ct-9916 8 11 and and CCONJ ct-9916 8 12 diagnostic diagnostic ADJ ct-9916 8 13 challenges challenge NOUN ct-9916 8 14 hypothyroidism hypothyroidism NOUN ct-9916 8 15 is be AUX ct-9916 8 16 the the DET ct-9916 8 17 most most ADV ct-9916 8 18 common common ADJ ct-9916 8 19 endocrine endocrine NOUN ct-9916 8 20 disease disease NOUN ct-9916 8 21 diagnosed diagnose VERB ct-9916 8 22 in in ADP ct-9916 8 23 canine canine NOUN ct-9916 8 24 practice practice NOUN ct-9916 8 25 , , PUNCT ct-9916 8 26 although although SCONJ ct-9916 8 27 true true ADJ ct-9916 8 28 disease disease NOUN ct-9916 8 29 prevalence prevalence NOUN ct-9916 8 30 is be AUX ct-9916 8 31 unknown.1,2 unknown.1,2 ADJ ct-9916 8 32 over over ADP ct-9916 8 33 90 90 NUM ct-9916 8 34 % % NOUN ct-9916 8 35 of of ADP ct-9916 8 36 cases case NOUN ct-9916 8 37 are be AUX ct-9916 8 38 due due ADJ ct-9916 8 39 to to ADP ct-9916 8 40 an an DET ct-9916 8 41 immune immune NOUN ct-9916 8 42 - - PUNCT ct-9916 8 43 mediated mediate VERB ct-9916 8 44 pathogenesis pathogenesis NOUN ct-9916 8 45 characterized characterize VERB ct-9916 8 46 by by ADP ct-9916 8 47 lymphocytic lymphocytic ADJ ct-9916 8 48 thyroiditis thyroiditis NOUN ct-9916 8 49 or or CCONJ ct-9916 8 50 idiopathic idiopathic ADJ ct-9916 8 51 follicular follicular ADJ ct-9916 8 52 atrophy.1,3 atrophy.1,3 NOUN ct-9916 8 53 rarely rarely ADV ct-9916 8 54 hypothyroidism hypothyroidism NOUN ct-9916 8 55 is be AUX ct-9916 8 56 due due ADJ ct-9916 8 57 to to ADP ct-9916 8 58 a a DET ct-9916 8 59 secondary secondary ADJ ct-9916 8 60 or or CCONJ ct-9916 8 61 tertiary tertiary ADJ ct-9916 8 62 pathogenesis pathogenesis NOUN ct-9916 8 63 , , PUNCT ct-9916 8 64 but but CCONJ ct-9916 8 65 those those PRON ct-9916 8 66 account account VERB ct-9916 8 67 for for ADP ct-9916 8 68     SPACE ct-9916 8 69 < < X ct-9916 8 70 5 5 NUM ct-9916 8 71 % % NOUN ct-9916 8 72 of of ADP ct-9916 8 73 cases.3 cases.3 PROPN ct-9916 8 74 gonadectomized gonadectomize VERB ct-9916 8 75 animals animal NOUN ct-9916 8 76 appear appear VERB ct-9916 8 77 to to PART ct-9916 8 78 be be AUX ct-9916 8 79 over over ADV ct-9916 8 80 - - PUNCT ct-9916 8 81 represented represent VERB ct-9916 8 82 and and CCONJ ct-9916 8 83 in in ADP ct-9916 8 84 euthyroid euthyroid NOUN ct-9916 8 85     SPACE ct-9916 8 86 animals animal NOUN ct-9916 8 87 circulating circulate VERB ct-9916 8 88 thyroid thyroid NOUN ct-9916 8 89 hormone hormone NOUN ct-9916 8 90 concentrations concentration NOUN ct-9916 8 91 decrease decrease VERB ct-9916 8 92 as as ADP ct-9916 8 93 dogs dog NOUN ct-9916 8 94 age age NOUN ct-9916 8 95 . . PUNCT ct-9916 9 1 disease disease NOUN ct-9916 9 2 onset onset NOUN ct-9916 9 3 is be AUX ct-9916 9 4 insidious insidious ADJ ct-9916 9 5 and and CCONJ ct-9916 9 6 can can AUX ct-9916 9 7 take take VERB ct-9916 9 8 months month NOUN ct-9916 9 9     SPACE ct-9916 9 10 to to ADP ct-9916 9 11 years year NOUN ct-9916 9 12 before before SCONJ ct-9916 9 13 any any DET ct-9916 9 14 clinical clinical ADJ ct-9916 9 15 signs sign NOUN ct-9916 9 16 develop.3 develop.3 ADP ct-9916 9 17 average average ADJ ct-9916 9 18 age age NOUN ct-9916 9 19 at at ADP ct-9916 9 20 onset onset NOUN ct-9916 9 21 of of ADP ct-9916 9 22 clinical clinical ADJ ct-9916 9 23 signs sign NOUN ct-9916 9 24 is be AUX ct-9916 9 25 7 7 NUM ct-9916 9 26 years year NOUN ct-9916 9 27 and and CCONJ ct-9916 9 28 clinical clinical ADJ ct-9916 9 29 signs sign NOUN ct-9916 9 30 overlap overlap VERB ct-9916 9 31 with with ADP ct-9916 9 32 other other ADJ ct-9916 9 33 endocrinopathies endocrinopathie NOUN ct-9916 9 34 in in ADP ct-9916 9 35 many many ADJ ct-9916 9 36 cases.1,3 cases.1,3 NOUN ct-9916 9 37 obesity obesity NOUN ct-9916 9 38 is be AUX ct-9916 9 39 present present ADJ ct-9916 9 40 in in ADP ct-9916 9 41 ~ ~ PUNCT ct-9916 9 42 50 50 NUM ct-9916 9 43 % % NOUN ct-9916 9 44 of of ADP ct-9916 9 45 cases case NOUN ct-9916 9 46 , , PUNCT ct-9916 9 47 followed follow VERB ct-9916 9 48 by by ADP ct-9916 9 49 dermatologic dermatologic ADJ ct-9916 9 50 aberrations aberration NOUN ct-9916 9 51 ( ( PUNCT ct-9916 9 52 present present ADJ ct-9916 9 53 in in ADP ct-9916 9 54 60 60 NUM ct-9916 9 55 80 80 NUM ct-9916 9 56 % % NOUN ct-9916 9 57 of of ADP ct-9916 9 58 dogs).3 dogs).3 ADJ ct-9916 9 59 dermatologic dermatologic ADJ ct-9916 9 60 conditions condition NOUN ct-9916 9 61 commonly commonly ADV ct-9916 9 62 include include VERB ct-9916 9 63 alopecia alopecia NOUN ct-9916 9 64 , , PUNCT ct-9916 9 65 seborrhea seborrhea ADJ ct-9916 9 66 , , PUNCT ct-9916 9 67 poor poor ADJ ct-9916 9 68 hair hair NOUN ct-9916 9 69 coat coat NOUN ct-9916 9 70 , , PUNCT ct-9916 9 71 and and CCONJ ct-9916 9 72 lethargy lethargy NOUN ct-9916 9 73 or or CCONJ ct-9916 9 74 a a DET ct-9916 9 75 dull dull ADJ ct-9916 9 76 mentation.1,3 mentation.1,3 ADJ ct-9916 9 77 several several ADJ ct-9916 9 78 breeds breed NOUN ct-9916 9 79 are be AUX ct-9916 9 80 at at ADP ct-9916 9 81 an an DET ct-9916 9 82 increased increase VERB ct-9916 9 83 risk risk NOUN ct-9916 9 84 of of ADP ct-9916 9 85 developing develop VERB ct-9916 9 86 hypothyroidism hypothyroidism NOUN ct-9916 9 87 , , PUNCT ct-9916 9 88 mainly mainly ADV ct-9916 9 89 , , PUNCT ct-9916 9 90 golden golden ADJ ct-9916 9 91 retrievers retriever NOUN ct-9916 9 92 and and CCONJ ct-9916 9 93 doberman doberman NOUN ct-9916 9 94 pinschers pinscher NOUN ct-9916 9 95 . . PUNCT ct-9916 10 1 beagles beagle NOUN ct-9916 10 2 and and CCONJ ct-9916 10 3 borzois borzois PROPN ct-9916 10 4 have have VERB ct-9916 10 5 heritable heritable ADJ ct-9916 10 6 lymphocytic lymphocytic ADJ ct-9916 10 7 thyroiditis.4,5 thyroiditis.4,5 NOUN ct-9916 10 8 breeds breed NOUN ct-9916 10 9 that that PRON ct-9916 10 10 have have VERB ct-9916 10 11 a a DET ct-9916 10 12 high high ADJ ct-9916 10 13 incidence incidence NOUN ct-9916 10 14 of of ADP ct-9916 10 15 thyroglobulin thyroglobulin PROPN ct-9916 10 16 autoantibodies autoantibody NOUN ct-9916 10 17 ( ( PUNCT ct-9916 10 18 tgaa tgaa PROPN ct-9916 10 19 ) ) PUNCT ct-9916 10 20 ( ( PUNCT ct-9916 10 21 antithyroglobulin antithyroglobulin PROPN ct-9916 10 22 antibodies antibodie VERB ct-9916 10 23 ) ) PUNCT ct-9916 10 24 include include VERB ct-9916 10 25 boxers boxer NOUN ct-9916 10 26 , , PUNCT ct-9916 10 27 dalmatians dalmatian NOUN ct-9916 10 28 , , PUNCT ct-9916 10 29 giant giant ADJ ct-9916 10 30 schnauzers schnauzer NOUN ct-9916 10 31 , , PUNCT ct-9916 10 32 great great ADJ ct-9916 10 33 danes dane NOUN ct-9916 10 34 , , PUNCT ct-9916 10 35 setters setter NOUN ct-9916 10 36 , , PUNCT ct-9916 10 37 and and CCONJ ct-9916 10 38 old old ADJ ct-9916 10 39 english english ADJ ct-9916 10 40 sheepdogs sheepdog NOUN ct-9916 10 41 , , PUNCT ct-9916 10 42 among among ADP ct-9916 10 43 others.1,3–7 others.1,3–7 NUM ct-9916 10 44 diagnosis diagnosis NOUN ct-9916 10 45 should should AUX ct-9916 10 46 be be AUX ct-9916 10 47 based base VERB ct-9916 10 48 on on ADP ct-9916 10 49 serologic serologic ADJ ct-9916 10 50 testing testing NOUN ct-9916 10 51 and and CCONJ ct-9916 10 52 not not PART ct-9916 10 53 on on ADP ct-9916 10 54 clinical clinical ADJ ct-9916 10 55 signs sign NOUN ct-9916 10 56 alone alone ADJ ct-9916 10 57 as as SCONJ ct-9916 10 58 there there PRON ct-9916 10 59 are be VERB ct-9916 10 60 many many ADJ ct-9916 10 61 diseases disease NOUN ct-9916 10 62 and and CCONJ ct-9916 10 63 medications medication NOUN ct-9916 10 64 , , PUNCT ct-9916 10 65 or or CCONJ ct-9916 10 66 even even ADV ct-9916 10 67 breed breed VERB ct-9916 10 68 differences difference NOUN ct-9916 10 69 , , PUNCT ct-9916 10 70 that that PRON ct-9916 10 71 contribute contribute VERB ct-9916 10 72 to to ADP ct-9916 10 73 altered altered ADJ ct-9916 10 74 circulating circulate VERB ct-9916 10 75 thyroid thyroid NOUN ct-9916 10 76 hormone hormone NOUN ct-9916 10 77 concentrations concentration NOUN ct-9916 10 78 . . PUNCT ct-9916 11 1 accurate accurate ADJ ct-9916 11 2 testing testing NOUN ct-9916 11 3 should should AUX ct-9916 11 4 be be AUX ct-9916 11 5 utilized utilize VERB ct-9916 11 6 before before SCONJ ct-9916 11 7 supplementation supplementation NOUN ct-9916 11 8 is be AUX ct-9916 11 9 considered consider VERB ct-9916 11 10 . . PUNCT ct-9916 12 1 both both DET ct-9916 12 2 3,5,3’-triiodothyronine 3,5,3’-triiodothyronine NUM ct-9916 12 3 ( ( PUNCT ct-9916 12 4 t3 t3 NOUN ct-9916 12 5 ) ) PUNCT ct-9916 12 6 and and CCONJ ct-9916 12 7 thyroxine thyroxine NOUN ct-9916 12 8 ( ( PUNCT ct-9916 12 9 t4 t4 PROPN ct-9916 12 10 ) ) PUNCT ct-9916 12 11 are be AUX ct-9916 12 12 highly highly ADV ct-9916 12 13 protein protein NOUN ct-9916 12 14 bound bind VERB ct-9916 12 15 and and CCONJ ct-9916 12 16 subject subject ADJ ct-9916 12 17 to to ADP ct-9916 12 18 drastic drastic ADJ ct-9916 12 19 changes change NOUN ct-9916 12 20 in in ADP ct-9916 12 21 concentrations concentration NOUN ct-9916 12 22 of of ADP ct-9916 12 23 albumin albumin NOUN ct-9916 12 24 and and CCONJ ct-9916 12 25 thyroxin thyroxin NOUN ct-9916 12 26 - - PUNCT ct-9916 12 27 binding bind VERB ct-9916 12 28 globulin.1 globulin.1 ADJ ct-9916 12 29 many many ADJ ct-9916 12 30 diseases disease NOUN ct-9916 12 31 can can AUX ct-9916 12 32 also also ADV ct-9916 12 33 falsely falsely ADV ct-9916 12 34 lower lower ADV ct-9916 12 35 circulating circulate VERB ct-9916 12 36 t4 t4 PROPN ct-9916 12 37 concentrations concentration NOUN ct-9916 12 38 and and CCONJ ct-9916 12 39 yield yield VERB ct-9916 12 40 a a DET ct-9916 12 41 diagnosis diagnosis NOUN ct-9916 12 42 of of ADP ct-9916 12 43 euthyroid euthyroid NOUN ct-9916 12 44 - - PUNCT ct-9916 12 45 sick sick ADJ ct-9916 12 46 syndrome syndrome NOUN ct-9916 12 47 . . PUNCT ct-9916 13 1 specific specific ADJ ct-9916 13 2 drugs drug NOUN ct-9916 13 3 can can AUX ct-9916 13 4 alter alter VERB ct-9916 13 5 circulating circulate VERB ct-9916 13 6 serum serum NOUN ct-9916 13 7 concentrations concentration NOUN ct-9916 13 8 of of ADP ct-9916 13 9 thyroid thyroid NOUN ct-9916 13 10 hormones hormone NOUN ct-9916 13 11 ; ; PUNCT ct-9916 13 12 therefore therefore ADV ct-9916 13 13 , , PUNCT ct-9916 13 14 any any DET ct-9916 13 15 animals animal NOUN ct-9916 13 16 being be AUX ct-9916 13 17 treated treat VERB ct-9916 13 18 with with ADP ct-9916 13 19 sulfonamides sulfonamide NOUN ct-9916 13 20 , , PUNCT ct-9916 13 21 glucocorticoids glucocorticoid NOUN ct-9916 13 22 , , PUNCT ct-9916 13 23 and/or and/or CCONJ ct-9916 13 24 phenobarbital phenobarbital ADJ ct-9916 13 25 should should AUX ct-9916 13 26 be be AUX ct-9916 13 27 tested test VERB ct-9916 13 28 after after ADP ct-9916 13 29 a a DET ct-9916 13 30 ‘ ' PUNCT ct-9916 13 31 washout washout NOUN ct-9916 13 32 ’ ' PUNCT ct-9916 13 33 period period NOUN ct-9916 13 34 , , PUNCT ct-9916 13 35 or or CCONJ ct-9916 13 36 if if SCONJ ct-9916 13 37 this this PRON ct-9916 13 38 is be AUX ct-9916 13 39 not not PART ct-9916 13 40 practical practical ADJ ct-9916 13 41 , , PUNCT ct-9916 13 42 the the DET ct-9916 13 43 results result NOUN ct-9916 13 44 should should AUX ct-9916 13 45 be be AUX ct-9916 13 46 interpreted interpret VERB ct-9916 13 47 carefully.1,3 carefully.1,3 PROPN ct-9916 13 48 there there PRON ct-9916 13 49 are be VERB ct-9916 13 50 lower low ADJ ct-9916 13 51 circulating circulate VERB ct-9916 13 52 t4 t4 PROPN ct-9916 13 53 concentrations concentration NOUN ct-9916 13 54 in in ADP ct-9916 13 55 specific specific ADJ ct-9916 13 56 breeds breed NOUN ct-9916 13 57 , , PUNCT ct-9916 13 58 including include VERB ct-9916 13 59 greyhounds greyhound NOUN ct-9916 13 60 , , PUNCT ct-9916 13 61 whippets whippet NOUN ct-9916 13 62 , , PUNCT ct-9916 13 63 scottish scottish ADJ ct-9916 13 64 deerhounds deerhound NOUN ct-9916 13 65 , , PUNCT ct-9916 13 66 basenji basenji NOUN ct-9916 13 67 , , PUNCT ct-9916 13 68 alaskan alaskan ADJ ct-9916 13 69 sled sle VERB ct-9916 13 70 dogs dog NOUN ct-9916 13 71 , , PUNCT ct-9916 13 72 and and CCONJ ct-9916 13 73 sloughis sloughis NOUN ct-9916 13 74 ; ; PUNCT ct-9916 13 75 these these DET ct-9916 13 76 breeds breed NOUN ct-9916 13 77 have have VERB ct-9916 13 78 breed breed NOUN ct-9916 13 79 - - PUNCT ct-9916 13 80 specific specific ADJ ct-9916 13 81 reference reference NOUN ct-9916 13 82 ranges1,3,8–11 ranges1,3,8–11 VERB ct-9916 13 83 importantly importantly ADV ct-9916 13 84 , , PUNCT ct-9916 13 85 euthyroid euthyroid PROPN ct-9916 13 86 dogs dog NOUN ct-9916 13 87 have have VERB ct-9916 13 88 lower low ADJ ct-9916 13 89 t4 t4 PROPN ct-9916 13 90 concentrations concentration NOUN ct-9916 13 91 at at ADP ct-9916 13 92 some some DET ct-9916 13 93 time time NOUN ct-9916 13 94 point point NOUN ct-9916 13 95 during during ADP ct-9916 13 96 the the DET ct-9916 13 97 day day NOUN ct-9916 13 98 , , PUNCT ct-9916 13 99 a a DET ct-9916 13 100 major major ADJ ct-9916 13 101 consideration consideration NOUN ct-9916 13 102 when when SCONJ ct-9916 13 103 testing testing NOUN ct-9916 13 104 is be AUX ct-9916 13 105 recommended.1 recommended.1 PROPN ct-9916 13 106 thyroxine thyroxine NOUN ct-9916 13 107 concentrations concentration NOUN ct-9916 13 108 are be AUX ct-9916 13 109 lower low ADJ ct-9916 13 110 in in ADP ct-9916 13 111 > > DET ct-9916 13 112 90 90 NUM ct-9916 13 113 % % NOUN ct-9916 13 114 of of ADP ct-9916 13 115 hypothyroid hypothyroid ADJ ct-9916 13 116 dogs dog NOUN ct-9916 13 117 . . PUNCT ct-9916 14 1 most most ADJ ct-9916 14 2 general general ADJ ct-9916 14 3 practitioners practitioner NOUN ct-9916 14 4 can can AUX ct-9916 14 5 use use VERB ct-9916 14 6 ‘ ' PUNCT ct-9916 14 7 in in ADP ct-9916 14 8 - - PUNCT ct-9916 14 9 house house NOUN ct-9916 14 10 ’ ' PUNCT ct-9916 14 11 serum serum PROPN ct-9916 14 12 t4 t4 PROPN ct-9916 14 13 concentration concentration NOUN ct-9916 14 14 tests test NOUN ct-9916 14 15 . . PUNCT ct-9916 15 1 this this DET ct-9916 15 2 test test NOUN ct-9916 15 3 is be AUX ct-9916 15 4 sensitive sensitive ADJ ct-9916 15 5 , , PUNCT ct-9916 15 6 but but CCONJ ct-9916 15 7 is be AUX ct-9916 15 8 not not PART ct-9916 15 9 specific specific ADJ ct-9916 15 10 for for ADP ct-9916 15 11 canine canine NOUN ct-9916 15 12 hypothyroidism hypothyroidism NOUN ct-9916 15 13 and and CCONJ ct-9916 15 14 should should AUX ct-9916 15 15 be be AUX ct-9916 15 16 avoided avoid VERB ct-9916 15 17 as as ADP ct-9916 15 18 a a DET ct-9916 15 19 single single ADJ ct-9916 15 20 test.1,3 test.1,3 NOUN ct-9916 15 21 the the DET ct-9916 15 22 most most ADV ct-9916 15 23 accurate accurate ADJ ct-9916 15 24 single single ADJ ct-9916 15 25 test test NOUN ct-9916 15 26 to to PART ct-9916 15 27 diagnose diagnose VERB ct-9916 15 28 hypothyroidism hypothyroidism NOUN ct-9916 15 29 is be AUX ct-9916 15 30 free free ADJ ct-9916 15 31 thyroxine thyroxine NOUN ct-9916 15 32 ( ( PUNCT ct-9916 15 33 ft4 ft4 NOUN ct-9916 15 34 ) ) PUNCT ct-9916 15 35 by by ADP ct-9916 15 36 equilibrium equilibrium NOUN ct-9916 15 37 dialysis.3 dialysis.3 NOUN ct-9916 15 38 thyroid thyroid NOUN ct-9916 15 39 †presented †presente VERB ct-9916 15 40 at at ADP ct-9916 15 41 the the DET ct-9916 15 42 2023 2023 NUM ct-9916 15 43 society society NOUN ct-9916 15 44 for for ADP ct-9916 15 45 theriogenology theriogenology NOUN ct-9916 15 46 conference conference NOUN ct-9916 15 47 , , PUNCT ct-9916 15 48 published publish VERB ct-9916 15 49 after after ADP ct-9916 15 50 peer peer NOUN ct-9916 15 51 review review NOUN ct-9916 15 52 . . PUNCT ct-9916 16 1 mailto:juliet@vt.edu mailto:juliet@vt.edu PROPN ct-9916 17 1 http://creativecommons.org/licenses/by-nc/4.0/ http://creativecommons.org/licenses/by-nc/4.0/ PROPN ct-9916 17 2 http://creativecommons.org/licenses/by-nc/4.0/ http://creativecommons.org/licenses/by-nc/4.0/ PROPN ct-9916 17 3 http://dx.doi.org/10.58292/ct.v15.9916 http://dx.doi.org/10.58292/ct.v15.9916 PROPN ct-9916 17 4 2 2 NUM ct-9916 17 5 citation citation NOUN ct-9916 17 6 line line NOUN ct-9916 17 7 : : PUNCT ct-9916 17 8 clinical clinical ADJ ct-9916 17 9 theriogenology theriogenology NOUN ct-9916 17 10 2023 2023 NUM ct-9916 17 11 , , PUNCT ct-9916 17 12 15 15 NUM ct-9916 17 13 , , PUNCT ct-9916 17 14 9916 9916 NUM ct-9916 17 15 , , PUNCT ct-9916 17 16 http://dx.doi.org/10.58292/ct.v15.9916 http://dx.doi.org/10.58292/ct.v15.9916 ADJ ct-9916 17 17 autoantibodies autoantibody NOUN ct-9916 17 18 , , PUNCT ct-9916 17 19 and and CCONJ ct-9916 17 20 to to ADP ct-9916 17 21 a a DET ct-9916 17 22 lesser less ADJ ct-9916 17 23 extent extent NOUN ct-9916 17 24 nonthyroidal nonthyroidal ADJ ct-9916 17 25 illness illness NOUN ct-9916 17 26 , , PUNCT ct-9916 17 27 do do AUX ct-9916 17 28 not not PART ct-9916 17 29 affect affect VERB ct-9916 17 30 ft4 ft4 NOUN ct-9916 17 31 concentrations concentration NOUN ct-9916 17 32 . . PUNCT ct-9916 18 1 combining combine VERB ct-9916 18 2 serum serum NOUN ct-9916 18 3 concentrations concentration NOUN ct-9916 18 4 of of ADP ct-9916 18 5 thyroid thyroid NOUN ct-9916 18 6 hormones hormone NOUN ct-9916 18 7 increases increase VERB ct-9916 18 8 success success NOUN ct-9916 18 9 in in ADP ct-9916 18 10 identifying identify VERB ct-9916 18 11 animals animal NOUN ct-9916 18 12 with with ADP ct-9916 18 13 true true ADJ ct-9916 18 14 hypothyroidism hypothyroidism NOUN ct-9916 18 15 . . PUNCT ct-9916 19 1 using use VERB ct-9916 19 2 thyrotropin thyrotropin PROPN ct-9916 19 3 ( ( PUNCT ct-9916 19 4 tsh tsh PROPN ct-9916 19 5 ) ) PUNCT ct-9916 19 6 information information NOUN ct-9916 19 7 with with ADP ct-9916 19 8 t4 t4 PROPN ct-9916 19 9 or or CCONJ ct-9916 19 10 ft4 ft4 PROPN ct-9916 19 11 typically typically ADV ct-9916 19 12 yields yield VERB ct-9916 19 13 a a DET ct-9916 19 14 98 98 NUM ct-9916 19 15 % % NOUN ct-9916 19 16 specificity.1,3 specificity.1,3 NOUN ct-9916 19 17 in in ADP ct-9916 19 18 sighthounds sighthound NOUN ct-9916 19 19 , , PUNCT ct-9916 19 20 t3 t3 PROPN ct-9916 19 21 concentrations concentration NOUN ct-9916 19 22 may may AUX ct-9916 19 23 be be AUX ct-9916 19 24 useful useful ADJ ct-9916 19 25 because because SCONJ ct-9916 19 26 their their PRON ct-9916 19 27 t4 t4 PROPN ct-9916 19 28 concentrations concentration NOUN ct-9916 19 29 are be AUX ct-9916 19 30 typically typically ADV ct-9916 19 31 outside outside ADJ ct-9916 19 32 reference reference NOUN ct-9916 19 33 ranges.3 ranges.3 VERB ct-9916 19 34 thyroglobulin thyroglobulin PROPN ct-9916 19 35 autoantibodies autoantibody NOUN ct-9916 19 36 ( ( PUNCT ct-9916 19 37 tgaa tgaa NOUN ct-9916 19 38 ) ) PUNCT ct-9916 19 39 form form NOUN ct-9916 19 40 as as SCONJ ct-9916 19 41 the the DET ct-9916 19 42 dog dog NOUN ct-9916 19 43 ’s ’s PART ct-9916 19 44 immune immune ADJ ct-9916 19 45 system system NOUN ct-9916 19 46 reacts react VERB ct-9916 19 47 to to ADP ct-9916 19 48 their their PRON ct-9916 19 49 thyroglobulin thyroglobulin NOUN ct-9916 19 50 and and CCONJ ct-9916 19 51 are be AUX ct-9916 19 52 present present ADJ ct-9916 19 53 in in ADP ct-9916 19 54 approximately approximately ADV ct-9916 19 55 50 50 NUM ct-9916 19 56 % % NOUN ct-9916 19 57 of of ADP ct-9916 19 58 all all DET ct-9916 19 59 hypothyroid hypothyroid ADJ ct-9916 19 60 dogs.3 dogs.3 ADJ ct-9916 19 61 animals animal NOUN ct-9916 19 62 that that PRON ct-9916 19 63 are be AUX ct-9916 19 64 positive positive ADJ ct-9916 19 65 for for ADP ct-9916 19 66 tgaa tgaa PROPN ct-9916 19 67 but but CCONJ ct-9916 19 68 with with ADP ct-9916 19 69 normal normal ADJ ct-9916 19 70 thyroid thyroid NOUN ct-9916 19 71 function function NOUN ct-9916 19 72 tests test NOUN ct-9916 19 73 should should AUX ct-9916 19 74 be be AUX ct-9916 19 75 retested reteste VERB ct-9916 19 76 annually annually ADV ct-9916 19 77 , , PUNCT ct-9916 19 78 as as SCONJ ct-9916 19 79 they they PRON ct-9916 19 80 have have VERB ct-9916 19 81 a a DET ct-9916 19 82 higher high ADJ ct-9916 19 83 risk risk NOUN ct-9916 19 84 of of ADP ct-9916 19 85 actually actually ADV ct-9916 19 86 developing develop VERB ct-9916 19 87 clinical clinical ADJ ct-9916 19 88 disease disease NOUN ct-9916 19 89 than than SCONJ ct-9916 19 90 do do AUX ct-9916 19 91 euthyroid euthyroid VERB ct-9916 19 92 dogs dog NOUN ct-9916 19 93 with with ADP ct-9916 19 94 negative negative ADJ ct-9916 19 95 tgaa.12 tgaa.12 NOUN ct-9916 19 96 reproductive reproductive ADJ ct-9916 19 97 manifestations manifestation NOUN ct-9916 19 98 hypothyroidism hypothyroidism NOUN ct-9916 19 99 in in ADP ct-9916 19 100 humans human NOUN ct-9916 19 101 has have AUX ct-9916 19 102 been be AUX ct-9916 19 103 studied study VERB ct-9916 19 104 extensively extensively ADV ct-9916 19 105 and and CCONJ ct-9916 19 106 is be AUX ct-9916 19 107 currently currently ADV ct-9916 19 108 ongoing ongoing ADJ ct-9916 19 109 . . PUNCT ct-9916 20 1 there there PRON ct-9916 20 2 are be VERB ct-9916 20 3 known know VERB ct-9916 20 4 reproductive reproductive ADJ ct-9916 20 5 manifestations manifestation NOUN ct-9916 20 6 that that PRON ct-9916 20 7 affect affect VERB ct-9916 20 8 both both DET ct-9916 20 9 women woman NOUN ct-9916 20 10 and and CCONJ ct-9916 20 11 men man NOUN ct-9916 20 12 . . PUNCT ct-9916 21 1 reports report NOUN ct-9916 21 2 include include VERB ct-9916 21 3 abnormal abnormal ADJ ct-9916 21 4 cyclicity cyclicity NOUN ct-9916 21 5 or or CCONJ ct-9916 21 6 anovulation anovulation NOUN ct-9916 21 7 , , PUNCT ct-9916 21 8 infertility infertility NOUN ct-9916 21 9 , , PUNCT ct-9916 21 10 loss loss NOUN ct-9916 21 11 of of ADP ct-9916 21 12 pregnancy pregnancy NOUN ct-9916 21 13 in in ADP ct-9916 21 14 women woman NOUN ct-9916 21 15 , , PUNCT ct-9916 21 16 and and CCONJ ct-9916 21 17 loss loss NOUN ct-9916 21 18 of of ADP ct-9916 21 19 libido libido NOUN ct-9916 21 20 or or CCONJ ct-9916 21 21 fertility fertility NOUN ct-9916 21 22 in in ADP ct-9916 21 23 men.13,14 men.13,14 ADJ ct-9916 21 24 women woman NOUN ct-9916 21 25 who who PRON ct-9916 21 26 did do AUX ct-9916 21 27 not not PART ct-9916 21 28 receive receive VERB ct-9916 21 29 adequate adequate ADJ ct-9916 21 30 supplementation supplementation NOUN ct-9916 21 31 of of ADP ct-9916 21 32 thyroid thyroid NOUN ct-9916 21 33 hormones hormone NOUN ct-9916 21 34 or or CCONJ ct-9916 21 35 who who PRON ct-9916 21 36 have have AUX ct-9916 21 37 had have VERB ct-9916 21 38 impaired impaired ADJ ct-9916 21 39 iodine iodine NOUN ct-9916 21 40 intake intake NOUN ct-9916 21 41 during during ADP ct-9916 21 42 pregnancy pregnancy NOUN ct-9916 21 43 had have VERB ct-9916 21 44 children child NOUN ct-9916 21 45 with with ADP ct-9916 21 46 substantial substantial ADJ ct-9916 21 47 effects,15,16 effects,15,16 ADJ ct-9916 21 48 particularly particularly ADV ct-9916 21 49 impaired impair VERB ct-9916 21 50 cognitive cognitive ADJ ct-9916 21 51 function function NOUN ct-9916 21 52 . . PUNCT ct-9916 22 1 the the DET ct-9916 22 2 relation relation NOUN ct-9916 22 3 between between ADP ct-9916 22 4 thyroid thyroid NOUN ct-9916 22 5 hormone hormone NOUN ct-9916 22 6 supplementation supplementation NOUN ct-9916 22 7 and and CCONJ ct-9916 22 8 diet diet NOUN ct-9916 22 9 is be AUX ct-9916 22 10 being be AUX ct-9916 22 11 elucidated elucidate VERB ct-9916 22 12 in in ADP ct-9916 22 13 women woman NOUN ct-9916 22 14 . . PUNCT ct-9916 23 1 the the DET ct-9916 23 2 effect effect NOUN ct-9916 23 3 of of ADP ct-9916 23 4 thyroid thyroid NOUN ct-9916 23 5 hormones hormone NOUN ct-9916 23 6 on on ADP ct-9916 23 7 both both CCONJ ct-9916 23 8 in in ADP ct-9916 23 9 vitro vitro X ct-9916 23 10 and and CCONJ ct-9916 23 11 in in ADP ct-9916 23 12 vivo vivo ADJ ct-9916 23 13 pregnancy pregnancy NOUN ct-9916 23 14 rates rate NOUN ct-9916 23 15 are be AUX ct-9916 23 16 also also ADV ct-9916 23 17 being be AUX ct-9916 23 18 studied study VERB ct-9916 23 19 . . PUNCT ct-9916 24 1 men man NOUN ct-9916 24 2 who who PRON ct-9916 24 3 were be AUX ct-9916 24 4 > > X ct-9916 24 5 35 35 NUM ct-9916 24 6 years year NOUN ct-9916 24 7 and and CCONJ ct-9916 24 8 subclinically subclinically ADV ct-9916 24 9 hypothyroid hypothyroid ADJ ct-9916 24 10 had have AUX ct-9916 24 11 decreased decrease VERB ct-9916 24 12 clinical clinical ADJ ct-9916 24 13 pregnancy pregnancy NOUN ct-9916 24 14 rate rate NOUN ct-9916 24 15 when when SCONJ ct-9916 24 16 compared compare VERB ct-9916 24 17 with with ADP ct-9916 24 18 their their PRON ct-9916 24 19 euthyroid euthyroid NOUN ct-9916 24 20 counterparts.14 counterparts.14 NOUN ct-9916 24 21 although although SCONJ ct-9916 24 22 these these DET ct-9916 24 23 findings finding NOUN ct-9916 24 24 are be AUX ct-9916 24 25 valid valid ADJ ct-9916 24 26 , , PUNCT ct-9916 24 27 it it PRON ct-9916 24 28 is be AUX ct-9916 24 29 important important ADJ ct-9916 24 30 to to PART ct-9916 24 31 notice notice VERB ct-9916 24 32 that that SCONJ ct-9916 24 33 human human ADJ ct-9916 24 34 and and CCONJ ct-9916 24 35 canine canine NOUN ct-9916 24 36 pregnancies pregnancy NOUN ct-9916 24 37 are be AUX ct-9916 24 38 very very ADV ct-9916 24 39 different different ADJ ct-9916 24 40 . . PUNCT ct-9916 25 1 humans human NOUN ct-9916 25 2 have have VERB ct-9916 25 3 higher high ADJ ct-9916 25 4 concentrations concentration NOUN ct-9916 25 5 of of ADP ct-9916 25 6 thyroxine thyroxine NOUN ct-9916 25 7 binding bind VERB ct-9916 25 8 globulins globulin NOUN ct-9916 25 9 ( ( PUNCT ct-9916 25 10 tbg tbg NOUN ct-9916 25 11 ) ) PUNCT ct-9916 25 12 and and CCONJ ct-9916 25 13 placental placental NOUN ct-9916 25 14 deiodinases deiodinase NOUN ct-9916 25 15 ; ; PUNCT ct-9916 25 16 both both PRON ct-9916 25 17 drastically drastically ADV ct-9916 25 18 increase increase VERB ct-9916 25 19 the the DET ct-9916 25 20 metabolic metabolic NOUN ct-9916 25 21 demand demand NOUN ct-9916 25 22 for for ADP ct-9916 25 23 thyroid thyroid NOUN ct-9916 25 24 hormones hormone NOUN ct-9916 25 25 during during ADP ct-9916 25 26 pregnancy.17 pregnancy.17 ADJ ct-9916 25 27 humans human NOUN ct-9916 25 28 also also ADV ct-9916 25 29 produce produce VERB ct-9916 25 30 human human ADJ ct-9916 25 31 chorionic chorionic ADJ ct-9916 25 32 gonadotropin gonadotropin NOUN ct-9916 25 33 ( ( PUNCT ct-9916 25 34 hcg hcg PROPN ct-9916 25 35 ) ) PUNCT ct-9916 25 36 in in ADP ct-9916 25 37 pregnancy pregnancy NOUN ct-9916 25 38 , , PUNCT ct-9916 25 39 which which PRON ct-9916 25 40 has have VERB ct-9916 25 41 substantial substantial ADJ ct-9916 25 42 thyrotropic thyrotropic ADJ ct-9916 25 43 activity.17 activity.17 PROPN ct-9916 25 44 broad broad PROPN ct-9916 25 45 assumptions assumption NOUN ct-9916 25 46 based base VERB ct-9916 25 47 on on ADP ct-9916 25 48 human human ADJ ct-9916 25 49 literature literature NOUN ct-9916 25 50 surrounding surround VERB ct-9916 25 51 hypothyroid hypothyroid ADJ ct-9916 25 52 disease disease NOUN ct-9916 25 53 and and CCONJ ct-9916 25 54 its its PRON ct-9916 25 55 reproductive reproductive ADJ ct-9916 25 56 effects effect NOUN ct-9916 25 57 in in ADP ct-9916 25 58 dogs dog NOUN ct-9916 25 59 should should AUX ct-9916 25 60 be be AUX ct-9916 25 61 avoided avoid VERB ct-9916 25 62 due due ADP ct-9916 25 63 to to ADP ct-9916 25 64 these these DET ct-9916 25 65 differences difference NOUN ct-9916 25 66 . . PUNCT ct-9916 26 1 fewer few ADJ ct-9916 26 2 studies study NOUN ct-9916 26 3 were be AUX ct-9916 26 4 performed perform VERB ct-9916 26 5 on on ADP ct-9916 26 6 dogs dog NOUN ct-9916 26 7 , , PUNCT ct-9916 26 8 but but CCONJ ct-9916 26 9 despite despite SCONJ ct-9916 26 10 the the DET ct-9916 26 11 lack lack NOUN ct-9916 26 12 of of ADP ct-9916 26 13 data datum NOUN ct-9916 26 14 , , PUNCT ct-9916 26 15 a a DET ct-9916 26 16 plethora plethora NOUN ct-9916 26 17 of of ADP ct-9916 26 18 reproductive reproductive ADJ ct-9916 26 19 diseases disease NOUN ct-9916 26 20 are be AUX ct-9916 26 21 ‘ ' PUNCT ct-9916 26 22 blamed blame VERB ct-9916 26 23 ’ ' PUNCT ct-9916 26 24 on on ADP ct-9916 26 25 hypothyroidism hypothyroidism NOUN ct-9916 26 26 . . PUNCT ct-9916 27 1 reports report NOUN ct-9916 27 2 have have AUX ct-9916 27 3 implicated implicate VERB ct-9916 27 4 hypothyroidism hypothyroidism NOUN ct-9916 27 5 for for ADP ct-9916 27 6 cycle cycle NOUN ct-9916 27 7 aberrations aberration NOUN ct-9916 27 8 , , PUNCT ct-9916 27 9 abortion abortion NOUN ct-9916 27 10 , , PUNCT ct-9916 27 11 infertility infertility NOUN ct-9916 27 12 , , PUNCT ct-9916 27 13 and and CCONJ ct-9916 27 14 stillbirth.3,18–20 stillbirth.3,18–20 X ct-9916 27 15 to to ADP ct-9916 27 16 date date NOUN ct-9916 27 17 only only ADV ct-9916 27 18 a a DET ct-9916 27 19 handful handful NOUN ct-9916 27 20 of of ADP ct-9916 27 21 prospective prospective ADJ ct-9916 27 22 studies study NOUN ct-9916 27 23 have have AUX ct-9916 27 24 been be AUX ct-9916 27 25 performed perform VERB ct-9916 27 26 specifically specifically ADV ct-9916 27 27 highlighting highlight VERB ct-9916 27 28 the the DET ct-9916 27 29 reproductive reproductive ADJ ct-9916 27 30 manifestations manifestation NOUN ct-9916 27 31 of of ADP ct-9916 27 32 hypothyroidism hypothyroidism NOUN ct-9916 27 33 in in ADP ct-9916 27 34 female female ADJ ct-9916 27 35 dogs dog NOUN ct-9916 27 36 . . PUNCT ct-9916 28 1 a a DET ct-9916 28 2 review review NOUN ct-9916 28 3 of of ADP ct-9916 28 4 204 204 NUM ct-9916 28 5 dog dog NOUN ct-9916 28 6 breeds breed NOUN ct-9916 28 7 suspected suspect VERB ct-9916 28 8 to to PART ct-9916 28 9 have have VERB ct-9916 28 10 heritable heritable ADJ ct-9916 28 11 hypothyroidism hypothyroidism NOUN ct-9916 28 12 failed fail VERB ct-9916 28 13 to to PART ct-9916 28 14 demonstrate demonstrate VERB ct-9916 28 15 any any DET ct-9916 28 16 significant significant ADJ ct-9916 28 17 difference difference NOUN ct-9916 28 18 in in ADP ct-9916 28 19 circulating circulate VERB ct-9916 28 20 thyroid thyroid NOUN ct-9916 28 21 hormone hormone NOUN ct-9916 28 22 concentrations concentration NOUN ct-9916 28 23 among among ADP ct-9916 28 24 normal normal ADJ ct-9916 28 25 , , PUNCT ct-9916 28 26 infertile infertile NOUN ct-9916 28 27 , , PUNCT ct-9916 28 28 and and CCONJ ct-9916 28 29 subfertile subfertile ADJ ct-9916 28 30 male male NOUN ct-9916 28 31 and and CCONJ ct-9916 28 32 female female ADJ ct-9916 28 33 individuals.7 individuals.7 NOUN ct-9916 28 34 additionally additionally ADV ct-9916 28 35 , , PUNCT ct-9916 28 36 a a DET ct-9916 28 37 large large ADJ ct-9916 28 38 prospective prospective ADJ ct-9916 28 39 study study NOUN ct-9916 28 40 that that SCONJ ct-9916 28 41 utilized utilize VERB ct-9916 28 42 fertile fertile ADJ ct-9916 28 43 , , PUNCT ct-9916 28 44 previously previously ADV ct-9916 28 45 proven prove VERB ct-9916 28 46 mongrel mongrel NOUN ct-9916 28 47 female female ADJ ct-9916 28 48 dogs dog NOUN ct-9916 28 49 , , PUNCT ct-9916 28 50 in in ADP ct-9916 28 51 which which PRON ct-9916 28 52 hypothyroidism hypothyroidism NOUN ct-9916 28 53 was be AUX ct-9916 28 54 induced induce VERB ct-9916 28 55 with with ADP ct-9916 28 56 131i 131i NUM ct-9916 28 57 treatment treatment NOUN ct-9916 28 58 , , PUNCT ct-9916 28 59 shed shed VERB ct-9916 28 60 some some DET ct-9916 28 61 light light NOUN ct-9916 28 62 on on ADP ct-9916 28 63 pregnancy pregnancy NOUN ct-9916 28 64 and and CCONJ ct-9916 28 65 hypothyroidism hypothyroidism NOUN ct-9916 28 66 . . PUNCT ct-9916 29 1 during during ADP ct-9916 29 2 the the DET ct-9916 29 3 short short ADJ ct-9916 29 4 - - PUNCT ct-9916 29 5 term term NOUN ct-9916 29 6 portion portion NOUN ct-9916 29 7 of of ADP ct-9916 29 8 the the DET ct-9916 29 9 study study NOUN ct-9916 29 10 , , PUNCT ct-9916 29 11 all all DET ct-9916 29 12 dogs dog NOUN ct-9916 29 13 cycled cycle VERB ct-9916 29 14 normally normally ADV ct-9916 29 15 , , PUNCT ct-9916 29 16 became become VERB ct-9916 29 17 pregnant pregnant ADJ ct-9916 29 18 and and CCONJ ct-9916 29 19 carried carry VERB ct-9916 29 20 their their PRON ct-9916 29 21 litters litter NOUN ct-9916 29 22 to to ADP ct-9916 29 23 term.21 term.21 NOUN ct-9916 29 24 furthermore furthermore ADV ct-9916 29 25 , , PUNCT ct-9916 29 26 there there PRON ct-9916 29 27 was be VERB ct-9916 29 28 no no DET ct-9916 29 29 difference difference NOUN ct-9916 29 30 in in ADP ct-9916 29 31 litter litter NOUN ct-9916 29 32 size size NOUN ct-9916 29 33 , , PUNCT ct-9916 29 34 although although SCONJ ct-9916 29 35 pups pup NOUN ct-9916 29 36 born bear VERB ct-9916 29 37 to to ADP ct-9916 29 38 hypothyroid hypothyroid ADJ ct-9916 29 39 dogs dog NOUN ct-9916 29 40 weighed weigh VERB ct-9916 29 41 less less ADV ct-9916 29 42 and and CCONJ ct-9916 29 43 experienced experience VERB ct-9916 29 44 more more ADJ ct-9916 29 45 periparturient periparturient NOUN ct-9916 29 46 mortality mortality NOUN ct-9916 29 47 . . PUNCT ct-9916 30 1 weight weight NOUN ct-9916 30 2 gain gain NOUN ct-9916 30 3 of of ADP ct-9916 30 4 pups pup NOUN ct-9916 30 5 was be AUX ct-9916 30 6 equal equal ADJ ct-9916 30 7 between between ADP ct-9916 30 8 the the DET ct-9916 30 9 groups group NOUN ct-9916 30 10 to to ADP ct-9916 30 11 day day NOUN ct-9916 30 12 28 28 NUM ct-9916 30 13 postpartum postpartum NOUN ct-9916 30 14 . . PUNCT ct-9916 31 1 the the DET ct-9916 31 2 increased increase VERB ct-9916 31 3 periparturient periparturient NOUN ct-9916 31 4 mortality mortality NOUN ct-9916 31 5 was be AUX ct-9916 31 6 attributed attribute VERB ct-9916 31 7 to to ADP ct-9916 31 8 possible possible ADJ ct-9916 31 9 prolonged prolonged ADJ ct-9916 31 10 uterine uterine ADJ ct-9916 31 11 contractions contraction NOUN ct-9916 31 12 that that PRON ct-9916 31 13 could could AUX ct-9916 31 14 be be AUX ct-9916 31 15 due due ADJ ct-9916 31 16 to to ADP ct-9916 31 17 generalized generalize VERB ct-9916 31 18 muscle muscle NOUN ct-9916 31 19 weakness weakness NOUN ct-9916 31 20 in in ADP ct-9916 31 21 hypothyroid hypothyroid ADJ ct-9916 31 22 patients.21 patients.21 PROPN ct-9916 31 23 a a DET ct-9916 31 24 second second ADJ ct-9916 31 25 article article NOUN ct-9916 31 26 , , PUNCT ct-9916 31 27 from from ADP ct-9916 31 28 the the DET ct-9916 31 29 same same ADJ ct-9916 31 30 cohort cohort NOUN ct-9916 31 31 , , PUNCT ct-9916 31 32 evaluated evaluate VERB ct-9916 31 33 the the DET ct-9916 31 34 effects effect NOUN ct-9916 31 35 of of ADP ct-9916 31 36 prolonged prolonged ADJ ct-9916 31 37 experimentally experimentally ADV ct-9916 31 38 induced induce VERB ct-9916 31 39 hypothyroidism hypothyroidism NOUN ct-9916 31 40 on on ADP ct-9916 31 41 reproduction reproduction NOUN ct-9916 31 42 . . PUNCT ct-9916 32 1 all all DET ct-9916 32 2 experimental experimental ADJ ct-9916 32 3 animals animal NOUN ct-9916 32 4 were be AUX ct-9916 32 5 profoundly profoundly ADV ct-9916 32 6 hypothyroid hypothyroid ADJ ct-9916 32 7 and and CCONJ ct-9916 32 8 had have VERB ct-9916 32 9 typical typical ADJ ct-9916 32 10 clinical clinical ADJ ct-9916 32 11 manifestations manifestation NOUN ct-9916 32 12 of of ADP ct-9916 32 13 weight weight NOUN ct-9916 32 14 gain gain NOUN ct-9916 32 15 , , PUNCT ct-9916 32 16 hair hair NOUN ct-9916 32 17 coat coat NOUN ct-9916 32 18 changes change NOUN ct-9916 32 19 , , PUNCT ct-9916 32 20 weakness weakness NOUN ct-9916 32 21 , , PUNCT ct-9916 32 22 and and CCONJ ct-9916 32 23 lethargy.22 lethargy.22 PROPN ct-9916 32 24 control control NOUN ct-9916 32 25 and and CCONJ ct-9916 32 26 hypothyroid hypothyroid ADJ ct-9916 32 27 female female ADJ ct-9916 32 28 dogs dog NOUN ct-9916 32 29 were be AUX ct-9916 32 30 bred breed VERB ct-9916 32 31 twice twice ADV ct-9916 32 32 during during ADP ct-9916 32 33 this this DET ct-9916 32 34 portion portion NOUN ct-9916 32 35 of of ADP ct-9916 32 36 the the DET ct-9916 32 37 study study NOUN ct-9916 32 38 , , PUNCT ct-9916 32 39 once once ADV ct-9916 32 40 without without ADP ct-9916 32 41 supplementation supplementation NOUN ct-9916 32 42 and and CCONJ ct-9916 32 43 once once ADV ct-9916 32 44 with with ADP ct-9916 32 45 levothyroxine levothyroxine NOUN ct-9916 32 46 supplementation supplementation NOUN ct-9916 32 47 . . PUNCT ct-9916 33 1 many many ADJ ct-9916 33 2 variables variable NOUN ct-9916 33 3 were be AUX ct-9916 33 4 monitored monitor VERB ct-9916 33 5 to to PART ct-9916 33 6 document document VERB ct-9916 33 7 the the DET ct-9916 33 8 effects effect NOUN ct-9916 33 9 of of ADP ct-9916 33 10 long long ADJ ct-9916 33 11 - - PUNCT ct-9916 33 12 term term NOUN ct-9916 33 13 uncontrolled uncontrolled ADJ ct-9916 33 14 hypothyroidism hypothyroidism NOUN ct-9916 33 15 during during ADP ct-9916 33 16 pregnancy pregnancy NOUN ct-9916 33 17 ( ( PUNCT ct-9916 33 18 2nd 2nd ADJ ct-9916 33 19 breeding breeding NOUN ct-9916 33 20 ) ) PUNCT ct-9916 33 21 and and CCONJ ct-9916 33 22 the the DET ct-9916 33 23 effects effect NOUN ct-9916 33 24 of of ADP ct-9916 33 25 supplementation supplementation NOUN ct-9916 33 26 and and CCONJ ct-9916 33 27 pregnancy pregnancy NOUN ct-9916 33 28 after after SCONJ ct-9916 33 29 clinical clinical ADJ ct-9916 33 30 signs sign NOUN ct-9916 33 31 were be AUX ct-9916 33 32 controlled control VERB ct-9916 33 33 ( ( PUNCT ct-9916 33 34 3rd 3rd ADJ ct-9916 33 35 breeding breeding NOUN ct-9916 33 36 ) ) PUNCT ct-9916 33 37 . . PUNCT ct-9916 34 1 the the DET ct-9916 34 2 interestrus interestrus PROPN ct-9916 34 3 interval interval NOUN ct-9916 34 4 ( ( PUNCT ct-9916 34 5 iei iei PROPN ct-9916 34 6 ) ) PUNCT ct-9916 34 7 , , PUNCT ct-9916 34 8 pregnancy pregnancy NOUN ct-9916 34 9 rates rate NOUN ct-9916 34 10 , , PUNCT ct-9916 34 11 and and CCONJ ct-9916 34 12 duration duration NOUN ct-9916 34 13 of of ADP ct-9916 34 14 pregnancy pregnancy NOUN ct-9916 34 15 were be AUX ct-9916 34 16 not not PART ct-9916 34 17 different different ADJ ct-9916 34 18 between between ADP ct-9916 34 19 groups.22 groups.22 NOUN ct-9916 34 20 following follow VERB ct-9916 34 21 the the DET ct-9916 34 22 second second ADJ ct-9916 34 23 breeding breeding NOUN ct-9916 34 24 , , PUNCT ct-9916 34 25 only only ADV ct-9916 34 26 half half NOUN ct-9916 34 27 of of ADP ct-9916 34 28 the the DET ct-9916 34 29 hypothyroid hypothyroid ADJ ct-9916 34 30 dogs dog NOUN ct-9916 34 31 became become VERB ct-9916 34 32 pregnant pregnant ADJ ct-9916 34 33 , , PUNCT ct-9916 34 34 highlighting highlight VERB ct-9916 34 35 profound profound ADJ ct-9916 34 36 long long ADJ ct-9916 34 37 - - PUNCT ct-9916 34 38 term term NOUN ct-9916 34 39 effects effect NOUN ct-9916 34 40 of of ADP ct-9916 34 41 hypothyroidism.22 hypothyroidism.22 NOUN ct-9916 34 42 ultimately ultimately ADV ct-9916 34 43 , , PUNCT ct-9916 34 44 levothyroxine levothyroxine PROPN ct-9916 34 45 supplementation supplementation NOUN ct-9916 34 46 eliminated eliminate VERB ct-9916 34 47 any any DET ct-9916 34 48 differences difference NOUN ct-9916 34 49 between between ADP ct-9916 34 50 the the DET ct-9916 34 51 groups group NOUN ct-9916 34 52 at at ADP ct-9916 34 53 the the DET ct-9916 34 54 3rd 3rd ADJ ct-9916 34 55 breeding.22 breeding.22 NOUN ct-9916 34 56 a a DET ct-9916 34 57 final final ADJ ct-9916 34 58 study study NOUN ct-9916 34 59 evaluated evaluate VERB ct-9916 34 60 circulating circulate VERB ct-9916 34 61 thyroid thyroid NOUN ct-9916 34 62 hormones hormone NOUN ct-9916 34 63 present present ADJ ct-9916 34 64 in in ADP ct-9916 34 65 the the DET ct-9916 34 66 hypothyroid hypothyroid ADJ ct-9916 34 67 female female ADJ ct-9916 34 68 dogs dog NOUN ct-9916 34 69 from from ADP ct-9916 34 70 the the DET ct-9916 34 71 3rd 3rd ADJ ct-9916 34 72 breeding breeding NOUN ct-9916 34 73 of of ADP ct-9916 34 74 the the DET ct-9916 34 75 same same ADJ ct-9916 34 76 cohort cohort NOUN ct-9916 34 77 . . PUNCT ct-9916 35 1 no no DET ct-9916 35 2 gestational gestational ADJ ct-9916 35 3 adjustments adjustment NOUN ct-9916 35 4 in in ADP ct-9916 35 5 thyroid thyroid NOUN ct-9916 35 6 supplementation supplementation NOUN ct-9916 35 7 were be AUX ct-9916 35 8 required require VERB ct-9916 35 9 for for ADP ct-9916 35 10 inducing induce VERB ct-9916 35 11 a a DET ct-9916 35 12 euthyroid euthyroid NOUN ct-9916 35 13 state state NOUN ct-9916 35 14 due due ADP ct-9916 35 15 to to ADP ct-9916 35 16 no no DET ct-9916 35 17 difference difference NOUN ct-9916 35 18 in in ADP ct-9916 35 19 thyroid thyroid NOUN ct-9916 35 20 hormone hormone NOUN ct-9916 35 21 concentrations concentration NOUN ct-9916 35 22 or or CCONJ ct-9916 35 23 progesterone progesterone NOUN ct-9916 35 24 concentrations concentration NOUN ct-9916 35 25 between between ADP ct-9916 35 26 groups group NOUN ct-9916 35 27 , , PUNCT ct-9916 35 28 which which PRON ct-9916 35 29 is be AUX ct-9916 35 30 drastically drastically ADV ct-9916 35 31 different different ADJ ct-9916 35 32 from from ADP ct-9916 35 33 hypothyroid hypothyroid ADJ ct-9916 35 34 women.17 women.17 NOUN ct-9916 35 35 another another DET ct-9916 35 36 study study NOUN ct-9916 35 37 evaluated evaluate VERB ct-9916 35 38 dogs dog NOUN ct-9916 35 39 that that PRON ct-9916 35 40 had have AUX ct-9916 35 41 aborted abort VERB ct-9916 35 42 their their PRON ct-9916 35 43 litters litter NOUN ct-9916 35 44 after after ADP ct-9916 35 45 4th 4th ADJ ct-9916 35 46 week week NOUN ct-9916 35 47 of of ADP ct-9916 35 48 pregnancy pregnancy NOUN ct-9916 35 49 . . PUNCT ct-9916 36 1 this this DET ct-9916 36 2 study study NOUN ct-9916 36 3 measured measure VERB ct-9916 36 4 only only ADV ct-9916 36 5 t4 t4 PROPN ct-9916 36 6 and and CCONJ ct-9916 36 7 progesterone progesterone NOUN ct-9916 36 8 and and CCONJ ct-9916 36 9 failed fail VERB ct-9916 36 10 to to PART ct-9916 36 11 conduct conduct VERB ct-9916 36 12 further further ADJ ct-9916 36 13 diagnostics diagnostic NOUN ct-9916 36 14 to to PART ct-9916 36 15 work work VERB ct-9916 36 16 up up ADP ct-9916 36 17 the the DET ct-9916 36 18 cause cause NOUN ct-9916 36 19 of of ADP ct-9916 36 20 abortion abortion NOUN ct-9916 36 21 . . PUNCT ct-9916 37 1 this this PRON ct-9916 37 2 leads lead VERB ct-9916 37 3 to to ADP ct-9916 37 4 only only ADV ct-9916 37 5 a a DET ct-9916 37 6 weak weak ADJ ct-9916 37 7 argument argument NOUN ct-9916 37 8 for for ADP ct-9916 37 9 a a DET ct-9916 37 10 direct direct ADJ ct-9916 37 11 effect effect NOUN ct-9916 37 12 of of ADP ct-9916 37 13 t4 t4 PROPN ct-9916 37 14 being be AUX ct-9916 37 15 a a DET ct-9916 37 16 singular singular ADJ ct-9916 37 17 cause cause NOUN ct-9916 37 18 of of ADP ct-9916 37 19 abortion.23 abortion.23 NOUN ct-9916 37 20 conflicting conflicting ADJ ct-9916 37 21 reports report NOUN ct-9916 37 22 exist exist VERB ct-9916 37 23 regarding regard VERB ct-9916 37 24 hypothyroidism hypothyroidism NOUN ct-9916 37 25 and and CCONJ ct-9916 37 26 its its PRON ct-9916 37 27 effects effect NOUN ct-9916 37 28 on on ADP ct-9916 37 29 male male ADJ ct-9916 37 30 dog dog NOUN ct-9916 37 31 fertility fertility NOUN ct-9916 37 32 . . PUNCT ct-9916 38 1 specific specific ADJ ct-9916 38 2 colonies colony NOUN ct-9916 38 3 containing contain VERB ct-9916 38 4 similar similar ADJ ct-9916 38 5 genetic genetic ADJ ct-9916 38 6 makeup makeup NOUN ct-9916 38 7 had have VERB ct-9916 38 8 both both DET ct-9916 38 9 hypothyroidism hypothyroidism NOUN ct-9916 38 10 and and CCONJ ct-9916 38 11 infertility2,5,24 infertility2,5,24 VERB ct-9916 38 12 due due ADP ct-9916 38 13 to to ADP ct-9916 38 14 the the DET ct-9916 38 15 specifics specific NOUN ct-9916 38 16 of of ADP ct-9916 38 17 genetic genetic ADJ ct-9916 38 18 makeup makeup NOUN ct-9916 38 19 of of ADP ct-9916 38 20 these these DET ct-9916 38 21 colonies colony NOUN ct-9916 38 22 , , PUNCT ct-9916 38 23 one one PRON ct-9916 38 24 might might AUX ct-9916 38 25 argue argue VERB ct-9916 38 26 that that SCONJ ct-9916 38 27 the the DET ct-9916 38 28 infertility infertility NOUN ct-9916 38 29 observed observe VERB ct-9916 38 30 may may AUX ct-9916 38 31 be be AUX ct-9916 38 32 due due ADJ ct-9916 38 33 to to ADP ct-9916 38 34 limited limited ADJ ct-9916 38 35 genetic genetic ADJ ct-9916 38 36 diversity diversity NOUN ct-9916 38 37 rather rather ADV ct-9916 38 38 than than ADP ct-9916 38 39 a a DET ct-9916 38 40 direct direct ADJ ct-9916 38 41 effect effect NOUN ct-9916 38 42 of of ADP ct-9916 38 43 low low ADJ ct-9916 38 44 circulating circulating ADJ ct-9916 38 45 thyroid thyroid NOUN ct-9916 38 46 hormones hormone NOUN ct-9916 38 47 . . PUNCT ct-9916 39 1 one one NUM ct-9916 39 2 1997 1997 NUM ct-9916 39 3 study study NOUN ct-9916 39 4 reported report VERB ct-9916 39 5 that that SCONJ ct-9916 39 6 induced induced ADJ ct-9916 39 7 hypothyroidism hypothyroidism NOUN ct-9916 39 8 did do AUX ct-9916 39 9 affect affect VERB ct-9916 39 10 male male ADJ ct-9916 39 11 dog dog NOUN ct-9916 39 12 fertility fertility NOUN ct-9916 39 13 but but CCONJ ct-9916 39 14 a a DET ct-9916 39 15 later later ADV ct-9916 39 16 ( ( PUNCT ct-9916 39 17 2009 2009 NUM ct-9916 39 18 ) ) PUNCT ct-9916 39 19 in in ADP ct-9916 39 20 vivo vivo NOUN ct-9916 39 21 study study NOUN ct-9916 39 22 reported report VERB ct-9916 39 23 no no DET ct-9916 39 24 statistical statistical ADJ ct-9916 39 25 difference difference NOUN ct-9916 39 26 in in ADP ct-9916 39 27 thyroid thyroid NOUN ct-9916 39 28 function function NOUN ct-9916 39 29 between between ADP ct-9916 39 30 fertile fertile ADJ ct-9916 39 31 and and CCONJ ct-9916 39 32 infertile infertile NOUN ct-9916 39 33 dogs.7,25 dogs.7,25 PROPN ct-9916 39 34 another another DET ct-9916 39 35 1999 1999 NUM ct-9916 39 36 study study NOUN ct-9916 39 37 utilized utilize VERB ct-9916 39 38 induced induce VERB ct-9916 39 39 hypothyroidic hypothyroidic ADJ ct-9916 39 40 dogs dog NOUN ct-9916 39 41 and and CCONJ ct-9916 39 42 noted note VERB ct-9916 39 43 no no DET ct-9916 39 44 change change NOUN ct-9916 39 45 in in ADP ct-9916 39 46 libido libido NOUN ct-9916 39 47 , , PUNCT ct-9916 39 48 daily daily ADJ ct-9916 39 49 sperm sperm NOUN ct-9916 39 50 output output NOUN ct-9916 39 51 , , PUNCT ct-9916 39 52 motility motility NOUN ct-9916 39 53 parameters parameter NOUN ct-9916 39 54 , , PUNCT ct-9916 39 55 nor nor CCONJ ct-9916 39 56 sperm sperm NOUN ct-9916 39 57 morphology morphology NOUN ct-9916 39 58 between between ADP ct-9916 39 59 control control NOUN ct-9916 39 60 and and CCONJ ct-9916 39 61 hypothyroid hypothyroid ADJ ct-9916 39 62 dogs.26 dogs.26 DET ct-9916 39 63 a a DET ct-9916 39 64 few few ADJ ct-9916 39 65 major major ADJ ct-9916 39 66 points point NOUN ct-9916 39 67 from from ADP ct-9916 39 68 these these DET ct-9916 39 69 studies study NOUN ct-9916 39 70 are be AUX ct-9916 39 71 important important ADJ ct-9916 39 72 . . PUNCT ct-9916 40 1 no no DET ct-9916 40 2 experimental experimental ADJ ct-9916 40 3 study study NOUN ct-9916 40 4 to to ADP ct-9916 40 5 date date NOUN ct-9916 40 6 has have AUX ct-9916 40 7 reproduced reproduce VERB ct-9916 40 8 reproductive reproductive ADJ ct-9916 40 9 failure failure NOUN ct-9916 40 10 following follow VERB ct-9916 40 11 an an DET ct-9916 40 12 immunogenic immunogenic ADJ ct-9916 40 13 hypothyroidism hypothyroidism NOUN ct-9916 40 14 mechanism mechanism NOUN ct-9916 40 15 , , PUNCT ct-9916 40 16 the the DET ct-9916 40 17 naturally naturally ADV ct-9916 40 18 occurring occur VERB ct-9916 40 19 disease disease NOUN ct-9916 40 20 in in ADP ct-9916 40 21 canine canine NOUN ct-9916 40 22 populations population NOUN ct-9916 40 23 . . PUNCT ct-9916 41 1 manifestations manifestation NOUN ct-9916 41 2 of of ADP ct-9916 41 3 any any DET ct-9916 41 4 reproductive reproductive ADJ ct-9916 41 5 failure failure NOUN ct-9916 41 6 have have AUX ct-9916 41 7 required require VERB ct-9916 41 8 elimination elimination NOUN ct-9916 41 9 of of ADP ct-9916 41 10 all all DET ct-9916 41 11 functional functional ADJ ct-9916 41 12 thyroid thyroid NOUN ct-9916 41 13 tissue tissue NOUN ct-9916 41 14 within within ADP ct-9916 41 15 the the DET ct-9916 41 16 animal animal NOUN ct-9916 41 17 . . PUNCT ct-9916 42 1 this this PRON ct-9916 42 2 raises raise VERB ct-9916 42 3 the the DET ct-9916 42 4 question question NOUN ct-9916 42 5 of of ADP ct-9916 42 6 whether whether SCONJ ct-9916 42 7 the the DET ct-9916 42 8 reproductive reproductive ADJ ct-9916 42 9 effects effect NOUN ct-9916 42 10 observed observe VERB ct-9916 42 11 are be AUX ct-9916 42 12 due due ADJ ct-9916 42 13 to to ADP ct-9916 42 14 the the DET ct-9916 42 15 lack lack NOUN ct-9916 42 16 of of ADP ct-9916 42 17 circulating circulate VERB ct-9916 42 18 hormones hormone NOUN ct-9916 42 19 or or CCONJ ct-9916 42 20 a a DET ct-9916 42 21 chronic chronic ADJ ct-9916 42 22 inflammatory inflammatory ADJ ct-9916 42 23 state state NOUN ct-9916 42 24 produced produce VERB ct-9916 42 25 by by ADP ct-9916 42 26 profound profound ADJ ct-9916 42 27 endocrine endocrine NOUN ct-9916 42 28 disease disease NOUN ct-9916 42 29 and and CCONJ ct-9916 42 30 associated associate VERB ct-9916 42 31 endocrine endocrine ADJ ct-9916 42 32 disruption disruption NOUN ct-9916 42 33 . . PUNCT ct-9916 43 1 furthermore furthermore ADV ct-9916 43 2 , , PUNCT ct-9916 43 3 many many ADJ ct-9916 43 4 of of ADP ct-9916 43 5 the the DET ct-9916 43 6 animals animal NOUN ct-9916 43 7 in in ADP ct-9916 43 8 the the DET ct-9916 43 9 studies study NOUN ct-9916 43 10 were be AUX ct-9916 43 11 obese obese ADJ ct-9916 43 12 , , PUNCT ct-9916 43 13 which which PRON ct-9916 43 14 is be AUX ct-9916 43 15 an an DET ct-9916 43 16 independent independent ADJ ct-9916 43 17 cause cause NOUN ct-9916 43 18 of of ADP ct-9916 43 19 reproductive reproductive ADJ ct-9916 43 20 failure failure NOUN ct-9916 43 21 in in ADP ct-9916 43 22 many many ADJ ct-9916 43 23 species specie NOUN ct-9916 43 24 . . PUNCT ct-9916 44 1 despite despite SCONJ ct-9916 44 2 these these DET ct-9916 44 3 drawbacks drawback NOUN ct-9916 44 4 , , PUNCT ct-9916 44 5 it it PRON ct-9916 44 6 is be AUX ct-9916 44 7 fair fair ADJ ct-9916 44 8 to to PART ct-9916 44 9 conclude conclude VERB ct-9916 44 10 that that DET ct-9916 44 11 primary primary ADJ ct-9916 44 12 hypothyroidism hypothyroidism NOUN ct-9916 44 13 and and CCONJ ct-9916 44 14 its its PRON ct-9916 44 15 effects effect NOUN ct-9916 44 16 on on ADP ct-9916 44 17 reproduction reproduction NOUN ct-9916 44 18 in in ADP ct-9916 44 19 canine canine NOUN ct-9916 44 20 patients patient NOUN ct-9916 44 21 are be AUX ct-9916 44 22 only only ADV ct-9916 44 23 weakly weakly ADV ct-9916 44 24 associated associate VERB ct-9916 44 25 . . PUNCT ct-9916 45 1 hypothyroidism hypothyroidism NOUN ct-9916 45 2 should should AUX ct-9916 45 3 be be AUX ct-9916 45 4 approached approach VERB ct-9916 45 5 cautiously cautiously ADV ct-9916 45 6 as as ADP ct-9916 45 7 a a DET ct-9916 45 8 cause cause NOUN ct-9916 45 9 of of ADP ct-9916 45 10 clinical clinical ADJ ct-9916 45 11 infertility infertility NOUN ct-9916 45 12 or or CCONJ ct-9916 45 13 subfertility subfertility NOUN ct-9916 45 14 . . PUNCT ct-9916 46 1 heritability heritability NOUN ct-9916 46 2 and and CCONJ ct-9916 46 3 testing testing NOUN ct-9916 46 4 breeding breeding NOUN ct-9916 46 5 animals animal NOUN ct-9916 46 6 many many ADJ ct-9916 46 7 breeds breed NOUN ct-9916 46 8 are be AUX ct-9916 46 9 labeled label VERB ct-9916 46 10 as as ADP ct-9916 46 11 ‘ ' PUNCT ct-9916 46 12 at at ADP ct-9916 46 13 risk risk NOUN ct-9916 46 14 ’ ' PUNCT ct-9916 46 15 for for ADP ct-9916 46 16 developing develop VERB ct-9916 46 17 hypothyroidism hypothyroidism NOUN ct-9916 46 18 . . PUNCT ct-9916 47 1 consequently consequently ADV ct-9916 47 2 , , PUNCT ct-9916 47 3 there there PRON ct-9916 47 4 is be VERB ct-9916 47 5 a a DET ct-9916 47 6 high high ADJ ct-9916 47 7 suspicion suspicion NOUN ct-9916 47 8 that that SCONJ ct-9916 47 9 a a DET ct-9916 47 10     SPACE ct-9916 47 11 heritable heritable ADJ ct-9916 47 12 http://dx.doi.org/10.58292/ct.v15.9916 http://dx.doi.org/10.58292/ct.v15.9916 PROPN ct-9916 47 13 citation citation NOUN ct-9916 47 14 line line NOUN ct-9916 47 15 : : PUNCT ct-9916 47 16 clinical clinical ADJ ct-9916 47 17 theriogenology theriogenology NOUN ct-9916 47 18 2023 2023 NUM ct-9916 47 19 , , PUNCT ct-9916 47 20 15 15 NUM ct-9916 47 21 , , PUNCT ct-9916 47 22 9916 9916 NUM ct-9916 47 23 , , PUNCT ct-9916 47 24 http://dx.doi.org/10.58292/ct.v15.9916 http://dx.doi.org/10.58292/ct.v15.9916 PROPN ct-9916 47 25 3 3 NUM ct-9916 47 26 and and CCONJ ct-9916 47 27 genetic genetic ADJ ct-9916 47 28 component component NOUN ct-9916 47 29 may may AUX ct-9916 47 30 be be AUX ct-9916 47 31 a a DET ct-9916 47 32 factor factor NOUN ct-9916 47 33 in in ADP ct-9916 47 34 developing develop VERB ct-9916 47 35 the the DET ct-9916 47 36 disease disease NOUN ct-9916 47 37 . . PUNCT ct-9916 48 1 the the DET ct-9916 48 2 insidious insidious ADJ ct-9916 48 3 nature nature NOUN ct-9916 48 4 of of ADP ct-9916 48 5 the the DET ct-9916 48 6 disease disease NOUN ct-9916 48 7 and and CCONJ ct-9916 48 8 difficulties difficulty NOUN ct-9916 48 9 surrounding surround VERB ct-9916 48 10 its its PRON ct-9916 48 11 definitive definitive ADJ ct-9916 48 12 diagnosis diagnosis NOUN ct-9916 48 13 have have AUX ct-9916 48 14 left leave VERB ct-9916 48 15 heritability heritability NOUN ct-9916 48 16 studies study NOUN ct-9916 48 17 as as ADP ct-9916 48 18 inconclusive inconclusive ADJ ct-9916 48 19 . . PUNCT ct-9916 49 1 this this PRON ct-9916 49 2 leads lead VERB ct-9916 49 3 to to ADP ct-9916 49 4 the the DET ct-9916 49 5 conclusion conclusion NOUN ct-9916 49 6 that that SCONJ ct-9916 49 7 the the DET ct-9916 49 8 underlying underlie VERB ct-9916 49 9 genetics genetic NOUN ct-9916 49 10 are be AUX ct-9916 49 11 likely likely ADJ ct-9916 49 12 a a DET ct-9916 49 13 polygenic polygenic ADJ ct-9916 49 14 trait trait NOUN ct-9916 49 15 that that PRON ct-9916 49 16 varies vary VERB ct-9916 49 17 from from ADP ct-9916 49 18 one one NUM ct-9916 49 19 breed breed NOUN ct-9916 49 20 to to ADP ct-9916 49 21 another another PRON ct-9916 49 22 and and CCONJ ct-9916 49 23 that that SCONJ ct-9916 49 24 developing develop VERB ct-9916 49 25 hypothyroidism hypothyroidism NOUN ct-9916 49 26 is be AUX ct-9916 49 27 also also ADV ct-9916 49 28 heavily heavily ADV ct-9916 49 29 influenced influence VERB ct-9916 49 30 by by ADP ct-9916 49 31 environmental environmental ADJ ct-9916 49 32 factors.6 factors.6 PROPN ct-9916 49 33 penetrance penetrance NOUN ct-9916 49 34 of of ADP ct-9916 49 35 the the DET ct-9916 49 36 offending offending ADJ ct-9916 49 37 alleles allele NOUN ct-9916 49 38 is be AUX ct-9916 49 39 also also ADV ct-9916 49 40 likely likely ADJ ct-9916 49 41 to to PART ct-9916 49 42 have have VERB ct-9916 49 43 a a DET ct-9916 49 44 role role NOUN ct-9916 49 45 in in ADP ct-9916 49 46 the the DET ct-9916 49 47 expression expression NOUN ct-9916 49 48 of of ADP ct-9916 49 49 clinical clinical ADJ ct-9916 49 50 disease disease NOUN ct-9916 49 51 . . PUNCT ct-9916 50 1 despite despite SCONJ ct-9916 50 2 these these DET ct-9916 50 3 drawbacks drawback NOUN ct-9916 50 4 , , PUNCT ct-9916 50 5 there there PRON ct-9916 50 6 are be VERB ct-9916 50 7 testing test VERB ct-9916 50 8 mechanisms mechanism NOUN ct-9916 50 9 that that PRON ct-9916 50 10 help help AUX ct-9916 50 11 screen screen VERB ct-9916 50 12 potential potential ADJ ct-9916 50 13 breeding breeding NOUN ct-9916 50 14 stock stock NOUN ct-9916 50 15 and and CCONJ ct-9916 50 16 assist assist VERB ct-9916 50 17 breeders breeder NOUN ct-9916 50 18 and and CCONJ ct-9916 50 19 veterinarians veterinarian NOUN ct-9916 50 20 in in ADP ct-9916 50 21 choosing choose VERB ct-9916 50 22 animals animal NOUN ct-9916 50 23 less less ADV ct-9916 50 24 likely likely ADJ ct-9916 50 25 to to PART ct-9916 50 26 pass pass VERB ct-9916 50 27 hypothyroidism hypothyroidism NOUN ct-9916 50 28 on on ADP ct-9916 50 29 to to ADP ct-9916 50 30 their their PRON ct-9916 50 31 offspring offspring NOUN ct-9916 50 32 . . PUNCT ct-9916 51 1 the the DET ct-9916 51 2 use use NOUN ct-9916 51 3 of of ADP ct-9916 51 4 specific specific ADJ ct-9916 51 5 , , PUNCT ct-9916 51 6 accurate accurate ADJ ct-9916 51 7 testing testing NOUN ct-9916 51 8 mechanisms mechanism NOUN ct-9916 51 9 is be AUX ct-9916 51 10 very very ADV ct-9916 51 11 important important ADJ ct-9916 51 12 . . PUNCT ct-9916 52 1 the the DET ct-9916 52 2 use use NOUN ct-9916 52 3 of of ADP ct-9916 52 4 a a DET ct-9916 52 5 single single ADJ ct-9916 52 6 t4 t4 PROPN ct-9916 52 7 or or CCONJ ct-9916 52 8 even even ADV ct-9916 52 9 t4 t4 PROPN ct-9916 52 10 combined combine VERB ct-9916 52 11 with with ADP ct-9916 52 12 tsh tsh NOUN ct-9916 52 13 should should AUX ct-9916 52 14 be be AUX ct-9916 52 15 avoided avoid VERB ct-9916 52 16 in in ADP ct-9916 52 17 screening screen VERB ct-9916 52 18 broodstock broodstock NOUN ct-9916 52 19 . . PUNCT ct-9916 53 1 a a DET ct-9916 53 2 full full ADJ ct-9916 53 3 panel panel NOUN ct-9916 53 4 including include VERB ct-9916 53 5 ft4 ft4 PROPN ct-9916 53 6 by by ADP ct-9916 53 7 equilibrium equilibrium NOUN ct-9916 53 8 dialysis dialysis NOUN ct-9916 53 9 , , PUNCT ct-9916 53 10 t4 t4 PROPN ct-9916 53 11 , , PUNCT ct-9916 53 12 ctsh ctsh NOUN ct-9916 53 13 , , PUNCT ct-9916 53 14 tgaa tgaa NOUN ct-9916 53 15 , , PUNCT ct-9916 53 16 and and CCONJ ct-9916 53 17 t3 t3 PROPN ct-9916 53 18 / / SYM ct-9916 53 19 ft3 ft3 PROPN ct-9916 53 20 should should AUX ct-9916 53 21 be be AUX ct-9916 53 22 used use VERB ct-9916 53 23 . . PUNCT ct-9916 54 1 animals animal NOUN ct-9916 54 2 that that PRON ct-9916 54 3 are be AUX ct-9916 54 4 exhibiting exhibit VERB ct-9916 54 5 signs sign NOUN ct-9916 54 6 of of ADP ct-9916 54 7 concurrent concurrent ADJ ct-9916 54 8 disease disease NOUN ct-9916 54 9 should should AUX ct-9916 54 10 not not PART ct-9916 54 11 be be AUX ct-9916 54 12 tested test VERB ct-9916 54 13 until until SCONJ ct-9916 54 14 the the DET ct-9916 54 15 disease disease NOUN ct-9916 54 16 state state NOUN ct-9916 54 17 has have AUX ct-9916 54 18 been be AUX ct-9916 54 19 resolved resolve VERB ct-9916 54 20 . . PUNCT ct-9916 55 1 testing testing NOUN ct-9916 55 2 should should AUX ct-9916 55 3 begin begin VERB ct-9916 55 4 around around ADV ct-9916 55 5 1 1 NUM ct-9916 55 6 year year NOUN ct-9916 55 7 of of ADP ct-9916 55 8 age age NOUN ct-9916 55 9 and and CCONJ ct-9916 55 10 should should AUX ct-9916 55 11 continue continue VERB ct-9916 55 12 every every DET ct-9916 55 13 1–2 1–2 NUM ct-9916 55 14 years year NOUN ct-9916 55 15 while while SCONJ ct-9916 55 16 the the DET ct-9916 55 17 animal animal NOUN ct-9916 55 18 is be AUX ct-9916 55 19 breeding breed VERB ct-9916 55 20 or or CCONJ ct-9916 55 21 until until SCONJ ct-9916 55 22 the the DET ct-9916 55 23 animal animal NOUN ct-9916 55 24 reaches reach VERB ct-9916 55 25 8–10 8–10 NOUN ct-9916 55 26 years year NOUN ct-9916 55 27 of of ADP ct-9916 55 28 age age NOUN ct-9916 55 29 . . PUNCT ct-9916 56 1 this this PRON ct-9916 56 2 allows allow VERB ct-9916 56 3 for for ADP ct-9916 56 4 identification identification NOUN ct-9916 56 5 of of ADP ct-9916 56 6 animals animal NOUN ct-9916 56 7 that that PRON ct-9916 56 8 may may AUX ct-9916 56 9 develop develop VERB ct-9916 56 10 subclinical subclinical ADJ ct-9916 56 11 disease disease NOUN ct-9916 56 12 over over ADP ct-9916 56 13 the the DET ct-9916 56 14 course course NOUN ct-9916 56 15 of of ADP ct-9916 56 16 their their PRON ct-9916 56 17 life life NOUN ct-9916 56 18 , , PUNCT ct-9916 56 19 despite despite SCONJ ct-9916 56 20 never never ADV ct-9916 56 21 having have VERB ct-9916 56 22 fulminant fulminant ADJ ct-9916 56 23 clinical clinical ADJ ct-9916 56 24 signs sign NOUN ct-9916 56 25 . . PUNCT ct-9916 57 1 it it PRON ct-9916 57 2 is be AUX ct-9916 57 3 important important ADJ ct-9916 57 4 to to PART ct-9916 57 5 remember remember VERB ct-9916 57 6 that that DET ct-9916 57 7 hypothyroidism hypothyroidism NOUN ct-9916 57 8 is be AUX ct-9916 57 9 a a DET ct-9916 57 10 disease disease NOUN ct-9916 57 11 that that PRON ct-9916 57 12 is be AUX ct-9916 57 13 easily easily ADV ct-9916 57 14 and and CCONJ ct-9916 57 15 successfully successfully ADV ct-9916 57 16 treated treat VERB ct-9916 57 17 . . PUNCT ct-9916 58 1 animals animal NOUN ct-9916 58 2 that that PRON ct-9916 58 3 may may AUX ct-9916 58 4 be be AUX ct-9916 58 5 tgaa tgaa VERB ct-9916 58 6 positive positive ADJ ct-9916 58 7 and and CCONJ ct-9916 58 8 remain remain VERB ct-9916 58 9 in in ADP ct-9916 58 10 the the DET ct-9916 58 11 normal normal ADJ ct-9916 58 12 range range NOUN ct-9916 58 13 of of ADP ct-9916 58 14 other other ADJ ct-9916 58 15 thyroid thyroid NOUN ct-9916 58 16 function function NOUN ct-9916 58 17 tests test NOUN ct-9916 58 18 should should AUX ct-9916 58 19 not not PART ct-9916 58 20 be be AUX ct-9916 58 21 eliminated eliminate VERB ct-9916 58 22 from from ADP ct-9916 58 23 the the DET ct-9916 58 24 breeding breeding NOUN ct-9916 58 25 pool pool NOUN ct-9916 58 26 , , PUNCT ct-9916 58 27 because because SCONJ ct-9916 58 28 eliminating eliminate VERB ct-9916 58 29 them they PRON ct-9916 58 30 can can AUX ct-9916 58 31 lead lead VERB ct-9916 58 32 to to ADP ct-9916 58 33 diminished diminished ADJ ct-9916 58 34 genetic genetic ADJ ct-9916 58 35 diversity diversity NOUN ct-9916 58 36 for for ADP ct-9916 58 37 many many ADJ ct-9916 58 38 other other ADJ ct-9916 58 39 traits trait NOUN ct-9916 58 40 . . PUNCT ct-9916 59 1 breeding breed VERB ct-9916 59 2 animals animal NOUN ct-9916 59 3 must must AUX ct-9916 59 4 be be AUX ct-9916 59 5 taken take VERB ct-9916 59 6 as as ADP ct-9916 59 7 a a DET ct-9916 59 8 whole whole NOUN ct-9916 59 9 , , PUNCT ct-9916 59 10 and and CCONJ ct-9916 59 11 breeders breeder NOUN ct-9916 59 12 should should AUX ct-9916 59 13 avoid avoid VERB ct-9916 59 14 ‘ ' PUNCT ct-9916 59 15 throwing throw VERB ct-9916 59 16 the the DET ct-9916 59 17 baby baby NOUN ct-9916 59 18 out out ADP ct-9916 59 19 with with ADP ct-9916 59 20 the the DET ct-9916 59 21 bathwater bathwater NOUN ct-9916 59 22 ’ ' PUNCT ct-9916 59 23 , , PUNCT ct-9916 59 24 especially especially ADV ct-9916 59 25 for for ADP ct-9916 59 26 a a DET ct-9916 59 27 disease disease NOUN ct-9916 59 28 that that PRON ct-9916 59 29 is be AUX ct-9916 59 30 so so ADV ct-9916 59 31 easily easily ADV ct-9916 59 32 treated treat VERB ct-9916 59 33 . . PUNCT ct-9916 60 1 levothyroxine levothyroxine PROPN ct-9916 60 2 supplementation supplementation NOUN ct-9916 60 3 only only ADV ct-9916 60 4 animals animal NOUN ct-9916 60 5 that that PRON ct-9916 60 6 had have VERB ct-9916 60 7 appropriate appropriate ADJ ct-9916 60 8 testing testing NOUN ct-9916 60 9 and and CCONJ ct-9916 60 10 elimination elimination NOUN ct-9916 60 11 of of ADP ct-9916 60 12 all all DET ct-9916 60 13 other other ADJ ct-9916 60 14 potential potential ADJ ct-9916 60 15 causes cause NOUN ct-9916 60 16 of of ADP ct-9916 60 17 infertility infertility NOUN ct-9916 60 18 should should AUX ct-9916 60 19 be be AUX ct-9916 60 20 considered consider VERB ct-9916 60 21 for for ADP ct-9916 60 22 levothyroxine levothyroxine NOUN ct-9916 60 23 supplementation supplementation NOUN ct-9916 60 24 . . PUNCT ct-9916 61 1 typically typically ADV ct-9916 61 2 , , PUNCT ct-9916 61 3 these these DET ct-9916 61 4 dogs dog NOUN ct-9916 61 5 have have AUX ct-9916 61 6 been be AUX ct-9916 61 7 bred breed VERB ct-9916 61 8 several several ADJ ct-9916 61 9 times time NOUN ct-9916 61 10 , , PUNCT ct-9916 61 11 conceived conceive VERB ct-9916 61 12 , , PUNCT ct-9916 61 13 and and CCONJ ct-9916 61 14 failed fail VERB ct-9916 61 15 to to PART ct-9916 61 16 deliver deliver VERB ct-9916 61 17 or or CCONJ ct-9916 61 18 lost lose VERB ct-9916 61 19 a a DET ct-9916 61 20 large large ADJ ct-9916 61 21 portion portion NOUN ct-9916 61 22 of of ADP ct-9916 61 23 their their PRON ct-9916 61 24 litter litter NOUN ct-9916 61 25 to to PART ct-9916 61 26 resorption resorption VERB ct-9916 61 27 during during ADP ct-9916 61 28 the the DET ct-9916 61 29 4th 4th ADJ ct-9916 61 30 to to ADP ct-9916 61 31 6th 6th ADJ ct-9916 61 32 week week NOUN ct-9916 61 33 of of ADP ct-9916 61 34 pregnancy pregnancy NOUN ct-9916 61 35 . . PUNCT ct-9916 62 1 documentation documentation NOUN ct-9916 62 2 of of ADP ct-9916 62 3 similar similar ADJ ct-9916 62 4 history history NOUN ct-9916 62 5 with with ADP ct-9916 62 6 appropriate appropriate ADJ ct-9916 62 7 diagnostics diagnostic NOUN ct-9916 62 8 , , PUNCT ct-9916 62 9 serial serial ADJ ct-9916 62 10 ultrasonographic ultrasonographic ADJ ct-9916 62 11 examinations examination NOUN ct-9916 62 12 of of ADP ct-9916 62 13 the the DET ct-9916 62 14 reproductive reproductive ADJ ct-9916 62 15 tract tract NOUN ct-9916 62 16 , , PUNCT ct-9916 62 17 infectious infectious ADJ ct-9916 62 18 disease disease NOUN ct-9916 62 19 testing testing NOUN ct-9916 62 20 , , PUNCT ct-9916 62 21 complete complete ADJ ct-9916 62 22 blood blood NOUN ct-9916 62 23 count count NOUN ct-9916 62 24 and and CCONJ ct-9916 62 25 biochemical biochemical ADJ ct-9916 62 26 profiles profile NOUN ct-9916 62 27 are be AUX ct-9916 62 28 warranted warrant VERB ct-9916 62 29 before before ADP ct-9916 62 30 considering consider VERB ct-9916 62 31 supplementation supplementation NOUN ct-9916 62 32 . . PUNCT ct-9916 63 1 this this PRON ct-9916 63 2 includes include VERB ct-9916 63 3 a a DET ct-9916 63 4 thorough thorough ADJ ct-9916 63 5 history history NOUN ct-9916 63 6 including include VERB ct-9916 63 7 pharmaceuticals pharmaceutical NOUN ct-9916 63 8 used use VERB ct-9916 63 9 ( ( PUNCT ct-9916 63 10 preventatives preventative NOUN ct-9916 63 11 and and CCONJ ct-9916 63 12 antibiotics antibiotic NOUN ct-9916 63 13 ) ) PUNCT ct-9916 63 14 , , PUNCT ct-9916 63 15 appropriate appropriate PROPN ct-9916 63 16 iei iei PROPN ct-9916 63 17 , , PUNCT ct-9916 63 18 breeding breeding NOUN ct-9916 63 19 method(s method(s NOUN ct-9916 63 20 ) ) PUNCT ct-9916 63 21 and and CCONJ ct-9916 63 22 timing timing NOUN ct-9916 63 23 , , PUNCT ct-9916 63 24 fertility fertility NOUN ct-9916 63 25 of of ADP ct-9916 63 26 the the DET ct-9916 63 27 sire sire NOUN ct-9916 63 28 , , PUNCT ct-9916 63 29 genetic genetic ADJ ct-9916 63 30 evaluation evaluation NOUN ct-9916 63 31 of of ADP ct-9916 63 32 the the DET ct-9916 63 33 breeding breeding NOUN ct-9916 63 34 pair pair NOUN ct-9916 63 35 , , PUNCT ct-9916 63 36 and and CCONJ ct-9916 63 37 any any DET ct-9916 63 38 other other ADJ ct-9916 63 39 comorbidities comorbiditie NOUN ct-9916 63 40 . . PUNCT ct-9916 64 1 intrauterine intrauterine ADJ ct-9916 64 2 cytology cytology NOUN ct-9916 64 3 , , PUNCT ct-9916 64 4 culture culture NOUN ct-9916 64 5 and/or and/or CCONJ ct-9916 64 6 biopsy biopsy NOUN ct-9916 64 7 should should AUX ct-9916 64 8 be be AUX ct-9916 64 9 performed perform VERB ct-9916 64 10 in in ADP ct-9916 64 11 early early ADJ ct-9916 64 12 proestrus proestrus NOUN ct-9916 64 13 , , PUNCT ct-9916 64 14 positive positive ADJ ct-9916 64 15 results result NOUN ct-9916 64 16 should should AUX ct-9916 64 17 be be AUX ct-9916 64 18 taken take VERB ct-9916 64 19 seriously seriously ADV ct-9916 64 20 ( ( PUNCT ct-9916 64 21 addressed address VERB ct-9916 64 22 and and CCONJ ct-9916 64 23 discussed discuss VERB ct-9916 64 24 ) ) PUNCT ct-9916 64 25 , , PUNCT ct-9916 64 26 and and CCONJ ct-9916 64 27 automatic automatic ADJ ct-9916 64 28 pharmaceutical pharmaceutical ADJ ct-9916 64 29 treatment treatment NOUN ct-9916 64 30 is be AUX ct-9916 64 31 avoided avoid VERB ct-9916 64 32 . . PUNCT ct-9916 65 1 if if SCONJ ct-9916 65 2 the the DET ct-9916 65 3 animal animal NOUN ct-9916 65 4 is be AUX ct-9916 65 5 timed time VERB ct-9916 65 6 appropriately appropriately ADV ct-9916 65 7 , , PUNCT ct-9916 65 8 bred breed VERB ct-9916 65 9 to to ADP ct-9916 65 10 a a DET ct-9916 65 11 proven prove VERB ct-9916 65 12 , , PUNCT ct-9916 65 13 fertile fertile ADJ ct-9916 65 14 sire sire NOUN ct-9916 65 15 and and CCONJ ct-9916 65 16 again again ADV ct-9916 65 17 fails fail VERB ct-9916 65 18 to to PART ct-9916 65 19 carry carry VERB ct-9916 65 20 to to ADP ct-9916 65 21 term term NOUN ct-9916 65 22 , , PUNCT ct-9916 65 23 then then ADV ct-9916 65 24 it it PRON ct-9916 65 25 is be AUX ct-9916 65 26 time time NOUN ct-9916 65 27 to to PART ct-9916 65 28 consider consider VERB ct-9916 65 29 supplementation supplementation NOUN ct-9916 65 30 . . PUNCT ct-9916 66 1 supplementing supplement VERB ct-9916 66 2 typically typically ADV ct-9916 66 3 causes cause VERB ct-9916 66 4 female female ADJ ct-9916 66 5 dogs dog NOUN ct-9916 66 6 to to PART ct-9916 66 7 be be AUX ct-9916 66 8 hyperthyroid hyperthyroid ADJ ct-9916 66 9 , , PUNCT ct-9916 66 10 and and CCONJ ct-9916 66 11 this this PRON ct-9916 66 12 should should AUX ct-9916 66 13 only only ADV ct-9916 66 14 be be AUX ct-9916 66 15 done do VERB ct-9916 66 16 if if SCONJ ct-9916 66 17 a a DET ct-9916 66 18 clear clear ADJ ct-9916 66 19 justification justification NOUN ct-9916 66 20 exists exist VERB ct-9916 66 21 . . PUNCT ct-9916 67 1 supplementation supplementation NOUN ct-9916 67 2 needs need VERB ct-9916 67 3 to to PART ct-9916 67 4 be be AUX ct-9916 67 5 fully fully ADV ct-9916 67 6 discussed discuss VERB ct-9916 67 7 prior prior ADV ct-9916 67 8 to to ADP ct-9916 67 9 implementation implementation NOUN ct-9916 67 10 . . PUNCT ct-9916 68 1 this this DET ct-9916 68 2 discussion discussion NOUN ct-9916 68 3 should should AUX ct-9916 68 4 include include VERB ct-9916 68 5 the the DET ct-9916 68 6 genetic genetic ADJ ct-9916 68 7 possibility possibility NOUN ct-9916 68 8 of of ADP ct-9916 68 9 needing need VERB ct-9916 68 10 exogenous exogenous ADJ ct-9916 68 11 hormone hormone NOUN ct-9916 68 12 therapies therapy NOUN ct-9916 68 13 to to PART ct-9916 68 14 maintain maintain VERB ct-9916 68 15 pregnancy pregnancy NOUN ct-9916 68 16 in in ADP ct-9916 68 17 their their PRON ct-9916 68 18 lines line NOUN ct-9916 68 19 . . PUNCT ct-9916 69 1 terminal terminal ADJ ct-9916 69 2 , , PUNCT ct-9916 69 3 performance performance NOUN ct-9916 69 4 breeding breeding NOUN ct-9916 69 5 is be AUX ct-9916 69 6 well well ADV ct-9916 69 7 accepted accept VERB ct-9916 69 8 , , PUNCT ct-9916 69 9 but but CCONJ ct-9916 69 10 a a DET ct-9916 69 11 kennel kennel NOUN ct-9916 69 12 that that PRON ct-9916 69 13 is be AUX ct-9916 69 14 experiencing experience VERB ct-9916 69 15 reproductive reproductive ADJ ct-9916 69 16 failure failure NOUN ct-9916 69 17 should should AUX ct-9916 69 18 carefully carefully ADV ct-9916 69 19 consider consider VERB ct-9916 69 20 eliminating eliminate VERB ct-9916 69 21 this this DET ct-9916 69 22 type type NOUN ct-9916 69 23 of of ADP ct-9916 69 24 animal animal NOUN ct-9916 69 25 as as ADP ct-9916 69 26 a a DET ct-9916 69 27 brood brood NOUN ct-9916 69 28 female female ADJ ct-9916 69 29 dog dog NOUN ct-9916 69 30 . . PUNCT ct-9916 70 1 once once ADV ct-9916 70 2 daily daily ADJ ct-9916 70 3 treatment treatment NOUN ct-9916 70 4 of of ADP ct-9916 70 5 oral oral ADJ ct-9916 70 6 levothyroxine levothyroxine NOUN ct-9916 70 7 ( ( PUNCT ct-9916 70 8 0.02 0.02 NUM ct-9916 70 9 mg mg NUM ct-9916 70 10 / / SYM ct-9916 70 11 kg kg PROPN ct-9916 70 12 ) ) PUNCT ct-9916 70 13 is be AUX ct-9916 70 14 sufficient sufficient ADJ ct-9916 70 15 for for ADP ct-9916 70 16 supplementation supplementation NOUN ct-9916 70 17 . . PUNCT ct-9916 71 1 treatment treatment NOUN ct-9916 71 2 for for ADP ct-9916 71 3 female female ADJ ct-9916 71 4 dogs dog NOUN ct-9916 71 5 should should AUX ct-9916 71 6 start start VERB ct-9916 71 7 as as ADV ct-9916 71 8 soon soon ADV ct-9916 71 9 as as SCONJ ct-9916 71 10 the the DET ct-9916 71 11 veterinarian veterinarian NOUN ct-9916 71 12 feels feel VERB ct-9916 71 13 that that SCONJ ct-9916 71 14 they they PRON ct-9916 71 15 fit fit VERB ct-9916 71 16 the the DET ct-9916 71 17 criteria criterion NOUN ct-9916 71 18 discussed discuss VERB ct-9916 71 19 above above ADV ct-9916 71 20 ( ( PUNCT ct-9916 71 21 during during ADP ct-9916 71 22 pregnancy pregnancy NOUN ct-9916 71 23 ) ) PUNCT ct-9916 71 24 or or CCONJ ct-9916 71 25 at at ADP ct-9916 71 26 the the DET ct-9916 71 27 beginning beginning NOUN ct-9916 71 28 of of ADP ct-9916 71 29 her her PRON ct-9916 71 30 next next ADJ ct-9916 71 31 estrous estrous ADJ ct-9916 71 32 cycle cycle NOUN ct-9916 71 33 and and CCONJ ct-9916 71 34 will will AUX ct-9916 71 35 be be AUX ct-9916 71 36 bred breed VERB ct-9916 71 37 . . PUNCT ct-9916 72 1 all all DET ct-9916 72 2 pregnancies pregnancy NOUN ct-9916 72 3 in in ADP ct-9916 72 4 these these DET ct-9916 72 5 dogs dog NOUN ct-9916 72 6 are be AUX ct-9916 72 7 considered consider VERB ct-9916 72 8 high high ADJ ct-9916 72 9 risk risk NOUN ct-9916 72 10 and and CCONJ ct-9916 72 11 should should AUX ct-9916 72 12 be be AUX ct-9916 72 13 monitored monitor VERB ct-9916 72 14 carefully carefully ADV ct-9916 72 15 and and CCONJ ct-9916 72 16 often often ADV ct-9916 72 17 . . PUNCT ct-9916 73 1 a a DET ct-9916 73 2 tapered tapered ADJ ct-9916 73 3 withdrawal withdrawal NOUN ct-9916 73 4 over over ADP ct-9916 73 5 2 2 NUM ct-9916 73 6 weeks week NOUN ct-9916 73 7 should should AUX ct-9916 73 8 be be AUX ct-9916 73 9 initiated initiate VERB ct-9916 73 10 immediately immediately ADV ct-9916 73 11 after after ADP ct-9916 73 12 whelping whelp VERB ct-9916 73 13 . . PUNCT ct-9916 74 1 typically typically ADV ct-9916 74 2 , , PUNCT ct-9916 74 3 these these DET ct-9916 74 4 dogs dog NOUN ct-9916 74 5 do do AUX ct-9916 74 6 not not PART ct-9916 74 7 have have VERB ct-9916 74 8 any any DET ct-9916 74 9 other other ADJ ct-9916 74 10 confounding confound VERB ct-9916 74 11 factors factor NOUN ct-9916 74 12 , , PUNCT ct-9916 74 13 and and CCONJ ct-9916 74 14 are be AUX ct-9916 74 15 without without ADP ct-9916 74 16 evidence evidence NOUN ct-9916 74 17 of of ADP ct-9916 74 18 endometritis endometritis NOUN ct-9916 74 19 , , PUNCT ct-9916 74 20 pyometra pyometra NOUN ct-9916 74 21 , , PUNCT ct-9916 74 22 or or CCONJ ct-9916 74 23 metritis metritis NOUN ct-9916 74 24 , , PUNCT ct-9916 74 25 hypoluteoidism hypoluteoidism NOUN ct-9916 74 26 , , PUNCT ct-9916 74 27 or or CCONJ ct-9916 74 28 other other ADJ ct-9916 74 29 causes cause NOUN ct-9916 74 30 of of ADP ct-9916 74 31 pregnancy pregnancy NOUN ct-9916 74 32 failure failure NOUN ct-9916 74 33 . . PUNCT ct-9916 75 1 breeders breeder NOUN ct-9916 75 2 often often ADV ct-9916 75 3 demand demand VERB ct-9916 75 4 supplementation supplementation NOUN ct-9916 75 5 well well ADV ct-9916 75 6 before before SCONJ ct-9916 75 7 a a DET ct-9916 75 8 clear clear ADJ ct-9916 75 9 cause cause NOUN ct-9916 75 10 is be AUX ct-9916 75 11 identified identify VERB ct-9916 75 12 ; ; PUNCT ct-9916 75 13 however however ADV ct-9916 75 14 , , PUNCT ct-9916 75 15 there there PRON ct-9916 75 16 is be VERB ct-9916 75 17 sufficient sufficient ADJ ct-9916 75 18 evidence evidence NOUN ct-9916 75 19 that that SCONJ ct-9916 75 20 the the DET ct-9916 75 21 thyroid thyroid NOUN ct-9916 75 22 gland gland NOUN ct-9916 75 23 must must AUX ct-9916 75 24 be be AUX ct-9916 75 25 profoundly profoundly ADV ct-9916 75 26 affected affect VERB ct-9916 75 27 before before SCONJ ct-9916 75 28 severe severe ADJ ct-9916 75 29 reproductive reproductive ADJ ct-9916 75 30 problems problem NOUN ct-9916 75 31 manifest manifest ADJ ct-9916 75 32 . . PUNCT ct-9916 76 1 this this PRON ct-9916 76 2 provides provide VERB ct-9916 76 3 a a DET ct-9916 76 4 clear clear ADJ ct-9916 76 5 path path NOUN ct-9916 76 6 to to PART ct-9916 76 7 appropriate appropriate VERB ct-9916 76 8 and and CCONJ ct-9916 76 9 science science NOUN ct-9916 76 10 - - PUNCT ct-9916 76 11 based base VERB ct-9916 76 12 supplementation supplementation NOUN ct-9916 76 13 . . PUNCT ct-9916 77 1 there there PRON ct-9916 77 2 may may AUX ct-9916 77 3 be be AUX ct-9916 77 4 another another DET ct-9916 77 5 mechanism mechanism NOUN ct-9916 77 6 in in ADP ct-9916 77 7 which which PRON ct-9916 77 8 thyroid thyroid NOUN ct-9916 77 9 supplementation supplementation NOUN ct-9916 77 10 will will AUX ct-9916 77 11 assist assist VERB ct-9916 77 12 these these DET ct-9916 77 13 specific specific ADJ ct-9916 77 14 cases case NOUN ct-9916 77 15 , , PUNCT ct-9916 77 16 but but CCONJ ct-9916 77 17 the the DET ct-9916 77 18 exact exact ADJ ct-9916 77 19 role role NOUN ct-9916 77 20 has have AUX ct-9916 77 21 not not PART ct-9916 77 22 been be AUX ct-9916 77 23 elucidated elucidate VERB ct-9916 77 24 and and CCONJ ct-9916 77 25 is be AUX ct-9916 77 26 the the DET ct-9916 77 27 very very ADJ ct-9916 77 28 reason reason NOUN ct-9916 77 29 for for ADP ct-9916 77 30 caution caution NOUN ct-9916 77 31 . . PUNCT ct-9916 78 1 this this PRON ct-9916 78 2 calls call VERB ct-9916 78 3 for for ADP ct-9916 78 4 the the DET ct-9916 78 5 judicious judicious ADJ ct-9916 78 6 use use NOUN ct-9916 78 7 of of ADP ct-9916 78 8 thyroid thyroid NOUN ct-9916 78 9 supplementation supplementation NOUN ct-9916 78 10 despite despite SCONJ ct-9916 78 11 what what PRON ct-9916 78 12 is be AUX ct-9916 78 13 known know VERB ct-9916 78 14 in in ADP ct-9916 78 15 breeder breeder NOUN ct-9916 78 16 community community NOUN ct-9916 78 17 as as ADP ct-9916 78 18 ‘ ' PUNCT ct-9916 78 19 breeder breeder NOUN ct-9916 78 20 lore lore NOUN ct-9916 78 21 ’ ' PUNCT ct-9916 78 22 . . PUNCT ct-9916 79 1 conclusion conclusion NOUN ct-9916 79 2 hypothyroidism hypothyroidism NOUN ct-9916 79 3 is be AUX ct-9916 79 4 a a DET ct-9916 79 5 common common ADJ ct-9916 79 6 disease disease NOUN ct-9916 79 7 of of ADP ct-9916 79 8 our our PRON ct-9916 79 9 canine canine NOUN ct-9916 79 10 population population NOUN ct-9916 79 11 and and CCONJ ct-9916 79 12 is be AUX ct-9916 79 13 difficult difficult ADJ ct-9916 79 14 to to PART ct-9916 79 15 definitively definitively ADV ct-9916 79 16 diagnose diagnose VERB ct-9916 79 17 . . PUNCT ct-9916 80 1 furthermore furthermore ADV ct-9916 80 2 , , PUNCT ct-9916 80 3 evidence evidence NOUN ct-9916 80 4 of of ADP ct-9916 80 5 direct direct ADJ ct-9916 80 6 cause cause NOUN ct-9916 80 7 and and CCONJ ct-9916 80 8 effect effect NOUN ct-9916 80 9 of of ADP ct-9916 80 10 hypothyroidism hypothyroidism NOUN ct-9916 80 11 and and CCONJ ct-9916 80 12 reproductive reproductive ADJ ct-9916 80 13 failure failure NOUN ct-9916 80 14 in in ADP ct-9916 80 15 a a DET ct-9916 80 16 natural natural ADJ ct-9916 80 17 disease disease NOUN ct-9916 80 18 state state NOUN ct-9916 80 19 is be AUX ct-9916 80 20 lacking lack VERB ct-9916 80 21 . . PUNCT ct-9916 81 1 reproductive reproductive ADJ ct-9916 81 2 veterinarians veterinarian NOUN ct-9916 81 3 need need VERB ct-9916 81 4 to to PART ct-9916 81 5 weigh weigh VERB ct-9916 81 6 all all PRON ct-9916 81 7 infectious infectious ADJ ct-9916 81 8 , , PUNCT ct-9916 81 9 genetic genetic ADJ ct-9916 81 10 , , PUNCT ct-9916 81 11 and and CCONJ ct-9916 81 12 husbandry husbandry ADJ ct-9916 81 13 causes cause NOUN ct-9916 81 14 of of ADP ct-9916 81 15 reproductive reproductive ADJ ct-9916 81 16 failure failure NOUN ct-9916 81 17 diligently diligently ADV ct-9916 81 18 and and CCONJ ct-9916 81 19 in in ADP ct-9916 81 20 a a DET ct-9916 81 21 systematic systematic ADJ ct-9916 81 22 approach approach NOUN ct-9916 81 23 before before SCONJ ct-9916 81 24 diagnosis diagnosis NOUN ct-9916 81 25 and and CCONJ ct-9916 81 26 supplementation supplementation NOUN ct-9916 81 27 of of ADP ct-9916 81 28 thyroid thyroid NOUN ct-9916 81 29 hormones hormone NOUN ct-9916 81 30 are be AUX ct-9916 81 31 implemented implement VERB ct-9916 81 32 . . PUNCT ct-9916 82 1 conflict conflict NOUN ct-9916 82 2 of of ADP ct-9916 82 3 interest interest NOUN ct-9916 82 4 the the DET ct-9916 82 5 author author NOUN ct-9916 82 6 declares declare VERB ct-9916 82 7 that that SCONJ ct-9916 82 8 she she PRON ct-9916 82 9 has have VERB ct-9916 82 10 no no DET ct-9916 82 11 conflict conflict NOUN ct-9916 82 12 of of ADP ct-9916 82 13 interest interest NOUN ct-9916 82 14 . . PUNCT ct-9916 83 1 references reference NOUN ct-9916 83 2 1 1 NUM ct-9916 83 3 . . PUNCT ct-9916 84 1 bruyette bruyette PROPN ct-9916 84 2 ds ds PROPN ct-9916 84 3 : : PUNCT ct-9916 84 4 canine canine NOUN ct-9916 84 5 hypothyroidism hypothyroidism NOUN ct-9916 84 6 . . PUNCT ct-9916 85 1 in in ADP ct-9916 85 2 : : PUNCT ct-9916 85 3 bruyette bruyette PROPN ct-9916 85 4 ds ds PROPN ct-9916 85 5 , , PUNCT ct-9916 85 6 bexfield bexfield NOUN ct-9916 85 7 n n CCONJ ct-9916 85 8 , , PUNCT ct-9916 85 9 chretin chretin PROPN ct-9916 85 10 jd jd PROPN ct-9916 85 11 , , PUNCT ct-9916 85 12 et et PROPN ct-9916 85 13 al al PROPN ct-9916 85 14 . . PROPN ct-9916 85 15 , , PUNCT ct-9916 85 16 editors editor NOUN ct-9916 85 17 . . PUNCT ct-9916 86 1 clinical clinical ADJ ct-9916 86 2 small small ADJ ct-9916 86 3 animal animal NOUN ct-9916 86 4 internal internal ADJ ct-9916 86 5 medicine medicine NOUN ct-9916 86 6 , , PUNCT ct-9916 86 7     SPACE ct-9916 86 8 vol vol NOUN ct-9916 86 9 . . PROPN ct-9916 86 10 1 1 NUM ct-9916 86 11 , , PUNCT ct-9916 86 12 john john PROPN ct-9916 86 13 wiley wiley PROPN ct-9916 86 14 & & CCONJ ct-9916 86 15 sons son NOUN ct-9916 86 16 , , PUNCT ct-9916 86 17 2020 2020 NUM ct-9916 86 18 , , PUNCT ct-9916 86 19 p. p. NOUN ct-9916 86 20 71–74 71–74 PROPN ct-9916 86 21 . . PUNCT ct-9916 87 1 doi doi NOUN ct-9916 87 2 : : PUNCT ct-9916 87 3 10.1002/9781119501237 10.1002/9781119501237 NUM ct-9916 87 4 2 2 X ct-9916 87 5 . . PUNCT ct-9916 87 6 fritz fritz PROPN ct-9916 87 7 te te PROPN ct-9916 87 8 , , PUNCT ct-9916 87 9 lombard lombard PROPN ct-9916 87 10 ls ls PROPN ct-9916 87 11 , , PUNCT ct-9916 87 12 tyler tyler PROPN ct-9916 87 13 sa sa PROPN ct-9916 87 14 , , PUNCT ct-9916 87 15 et et PROPN ct-9916 87 16 al al PROPN ct-9916 87 17 : : PUNCT ct-9916 87 18 pathology pathology NOUN ct-9916 87 19 and and CCONJ ct-9916 87 20 familial familial ADJ ct-9916 87 21 incidence incidence NOUN ct-9916 87 22 of of ADP ct-9916 87 23 orchitis orchitis NOUN ct-9916 87 24 and and CCONJ ct-9916 87 25 its its PRON ct-9916 87 26 relation relation NOUN ct-9916 87 27 to to ADP ct-9916 87 28 thyroiditis thyroiditis NOUN ct-9916 87 29 in in ADP ct-9916 87 30 a a DET ct-9916 87 31 closed closed ADJ ct-9916 87 32 beagle beagle NOUN ct-9916 87 33 colony colony NOUN ct-9916 87 34 . . PUNCT ct-9916 88 1 exp exp NOUN ct-9916 88 2 mol mol ADP ct-9916 88 3 pathol pathol NOUN ct-9916 88 4 1976;24:142–158 1976;24:142–158 NUM ct-9916 88 5 . . PUNCT ct-9916 89 1 doi doi NOUN ct-9916 89 2 : : PUNCT ct-9916 89 3 10.1016/0014 10.1016/0014 NUM ct-9916 89 4 - - PUNCT ct-9916 89 5 4800(76)90002 4800(76)90002 NUM ct-9916 89 6 - - SYM ct-9916 89 7 2 2 NUM ct-9916 89 8 3 3 NUM ct-9916 89 9 . . PUNCT ct-9916 90 1 panciera panciera NOUN ct-9916 91 1 d d NOUN ct-9916 91 2 : : PUNCT ct-9916 91 3 hypothyroidism hypothyroidism NOUN ct-9916 91 4 in in ADP ct-9916 91 5 dogs dog NOUN ct-9916 91 6 . . PUNCT ct-9916 92 1 in in ADP ct-9916 92 2 : : PUNCT ct-9916 92 3 j j PROPN ct-9916 92 4 rand rand PROPN ct-9916 92 5 , , PUNCT ct-9916 92 6 editor editor NOUN ct-9916 92 7 . . PUNCT ct-9916 93 1 clinical clinical ADJ ct-9916 93 2 endocrinology endocrinology NOUN ct-9916 93 3 of of ADP ct-9916 93 4 companion companion NOUN ct-9916 93 5 animals animal NOUN ct-9916 93 6 . . PUNCT ct-9916 94 1 john john PROPN ct-9916 94 2 wiley wiley PROPN ct-9916 94 3 & & CCONJ ct-9916 94 4 sons son NOUN ct-9916 94 5 , , PUNCT ct-9916 94 6 2013 2013 NUM ct-9916 94 7 , , PUNCT ct-9916 94 8 p. p. NOUN ct-9916 94 9 263–272 263–272 NUM ct-9916 94 10 . . PUNCT ct-9916 95 1 doi doi NOUN ct-9916 95 2 : : PUNCT ct-9916 95 3 10.1002/9781118997093 10.1002/9781118997093 NUM ct-9916 95 4 4 4 NUM ct-9916 95 5 . . PUNCT ct-9916 96 1 benjamin benjamin PROPN ct-9916 96 2 s s PROPN ct-9916 96 3 , , PUNCT ct-9916 96 4 stephens stephens PROPN ct-9916 96 5 l l PROPN ct-9916 96 6 , , PUNCT ct-9916 96 7 hamilton hamilton PROPN ct-9916 96 8 b b PROPN ct-9916 96 9 , , PUNCT ct-9916 96 10 et et PROPN ct-9916 96 11 al al PROPN ct-9916 96 12 : : PUNCT ct-9916 96 13 associations association NOUN ct-9916 96 14 between between ADP ct-9916 96 15     SPACE ct-9916 96 16 lymphocytic lymphocytic ADJ ct-9916 96 17 thyroiditis thyroiditis NOUN ct-9916 96 18 , , PUNCT ct-9916 96 19 hypothyroidism hypothyroidism NOUN ct-9916 96 20 , , PUNCT ct-9916 96 21 and and CCONJ ct-9916 96 22 thyroid thyroid VERB ct-9916 96 23 neoplasia neoplasia NOUN ct-9916 96 24 in in ADP ct-9916 96 25 beagles beagle NOUN ct-9916 96 26 . . PUNCT ct-9916 97 1 vet vet NOUN ct-9916 97 2 pathol pathol NOUN ct-9916 97 3 1996;33:486–496 1996;33:486–496 NOUN ct-9916 97 4 . . PUNCT ct-9916 98 1 doi doi NOUN ct-9916 98 2 : : PUNCT ct-9916 98 3 10.1177/030098589603300502 10.1177/030098589603300502 NUM ct-9916 98 4 5 5 X ct-9916 98 5 . . PUNCT ct-9916 98 6 conaway conaway PROPN ct-9916 98 7 dh dh PROPN ct-9916 98 8 , , PUNCT ct-9916 98 9 padgett padgett PROPN ct-9916 98 10 ga ga PROPN ct-9916 98 11 , , PUNCT ct-9916 98 12 nachreiner nachreiner PROPN ct-9916 98 13 rf rf NOUN ct-9916 98 14 , , PUNCT ct-9916 98 15 et et PROPN ct-9916 98 16 al al PROPN ct-9916 98 17 : : PUNCT ct-9916 98 18 the the DET ct-9916 98 19 familial familial ADJ ct-9916 98 20 occurrence occurrence NOUN ct-9916 98 21 of of ADP ct-9916 98 22 lymphocytic lymphocytic ADJ ct-9916 98 23 thyroiditis thyroiditis NOUN ct-9916 98 24 in in ADP ct-9916 98 25 borzoi borzoi NOUN ct-9916 98 26 dogs dog NOUN ct-9916 98 27 . . PUNCT ct-9916 99 1 am be AUX ct-9916 99 2 j j PROPN ct-9916 99 3 med med PROPN ct-9916 99 4 genet genet PROPN ct-9916 99 5 1985;22:409–414 1985;22:409–414 PROPN ct-9916 99 6 . . PUNCT ct-9916 100 1 doi doi NOUN ct-9916 100 2 : : PUNCT ct-9916 100 3 10.1002 10.1002 NUM ct-9916 100 4 / / SYM ct-9916 100 5 ajmg.1320220226 ajmg.1320220226 PROPN ct-9916 100 6 6 6 NUM ct-9916 100 7 . . PUNCT ct-9916 101 1 åhlgren åhlgren PROPN ct-9916 101 2 j j PROPN ct-9916 101 3 , , PUNCT ct-9916 101 4 uimari uimari PROPN ct-9916 101 5 p p X ct-9916 101 6 : : PUNCT ct-9916 101 7 heritability heritability NOUN ct-9916 101 8 of of ADP ct-9916 101 9 hypothyroidism hypothyroidism NOUN ct-9916 101 10 in in ADP ct-9916 101 11 the the DET ct-9916 101 12 finnish finnish ADJ ct-9916 101 13 hovawart hovawart PROPN ct-9916 101 14 population population NOUN ct-9916 101 15 . . PUNCT ct-9916 102 1 acta acta PROPN ct-9916 102 2 vet vet PROPN ct-9916 102 3 scand scand PROPN ct-9916 102 4 2015;58:1–5 2015;58:1–5 NUM ct-9916 102 5 . . PUNCT ct-9916 103 1 doi doi NOUN ct-9916 103 2 : : PUNCT ct-9916 103 3 10.1186/ 10.1186/ NUM ct-9916 103 4 s13028 s13028 PROPN ct-9916 103 5 - - PUNCT ct-9916 103 6 016 016 NUM ct-9916 103 7 - - PUNCT ct-9916 103 8 0221 0221 NUM ct-9916 103 9 - - SYM ct-9916 103 10 8 8 NUM ct-9916 103 11 7 7 NUM ct-9916 103 12 . . PUNCT ct-9916 103 13 segalini segalini PROPN ct-9916 103 14 v v PROPN ct-9916 103 15 , , PUNCT ct-9916 103 16 hericher hericher PROPN ct-9916 103 17 t t PROPN ct-9916 103 18 , , PUNCT ct-9916 103 19 grellet grellet VERB ct-9916 103 20 a a PRON ct-9916 103 21 , , PUNCT ct-9916 103 22 et et PROPN ct-9916 103 23 al al PROPN ct-9916 103 24 : : PUNCT ct-9916 103 25 thyroid thyroid NOUN ct-9916 103 26 function function NOUN ct-9916 103 27 and and CCONJ ct-9916 103 28 infertility infertility NOUN ct-9916 103 29 in in ADP ct-9916 103 30 the the DET ct-9916 103 31 dog dog NOUN ct-9916 103 32 : : PUNCT ct-9916 103 33 a a DET ct-9916 103 34 survey survey NOUN ct-9916 103 35 in in ADP ct-9916 103 36 five five NUM ct-9916 103 37 breeds breed NOUN ct-9916 103 38 . . PUNCT ct-9916 104 1 reprod reprod PROPN ct-9916 104 2 domest domest PROPN ct-9916 104 3 anim anim NOUN ct-9916 104 4 2009;44:211–213 2009;44:211–213 PROPN ct-9916 104 5 . . PUNCT ct-9916 105 1 doi doi NOUN ct-9916 105 2 : : PUNCT ct-9916 105 3 10.1111 10.1111 NUM ct-9916 105 4 / / SYM ct-9916 105 5 j.1439 j.1439 NOUN ct-9916 105 6 - - PUNCT ct-9916 105 7 0531.2009.01445.x 0531.2009.01445.x NOUN ct-9916 105 8 http://dx.doi.org/10.58292/ct.v15.9916 http://dx.doi.org/10.58292/ct.v15.9916 PROPN ct-9916 105 9 https://doi.org/10.1002/9781119501237 https://doi.org/10.1002/9781119501237 INTJ ct-9916 105 10 https://doi.org/10.1016/0014-4800(76)90002-2 https://doi.org/10.1016/0014-4800(76)90002-2 PROPN ct-9916 105 11 https://doi.org/10.1002/9781118997093 https://doi.org/10.1002/9781118997093 PRON ct-9916 105 12 https://doi.org/10.1177/030098589603300502 https://doi.org/10.1177/030098589603300502 PUNCT ct-9916 106 1 https://doi.org/10.1002/ajmg.1320220226 https://doi.org/10.1002/ajmg.1320220226 NUM ct-9916 106 2 https://doi.org/10.1186/s13028-016-0221-8 https://doi.org/10.1186/s13028-016-0221-8 NUM ct-9916 106 3 https://doi.org/10.1186/s13028-016-0221-8 https://doi.org/10.1186/s13028-016-0221-8 NUM ct-9916 106 4 https://doi.org/10.1111/j.1439-0531.2009.01445.x https://doi.org/10.1111/j.1439-0531.2009.01445.x NOUN ct-9916 106 5 4 4 NUM ct-9916 106 6 citation citation NOUN ct-9916 106 7 line line NOUN ct-9916 106 8 : : PUNCT ct-9916 106 9 clinical clinical ADJ ct-9916 106 10 theriogenology theriogenology NOUN ct-9916 106 11 2023 2023 NUM ct-9916 106 12 , , PUNCT ct-9916 106 13 15 15 NUM ct-9916 106 14 , , PUNCT ct-9916 106 15 9916 9916 NUM ct-9916 106 16 , , PUNCT ct-9916 106 17 http://dx.doi.org/10.58292/ct.v15.9916 http://dx.doi.org/10.58292/ct.v15.9916 PROPN ct-9916 106 18 8 8 NUM ct-9916 106 19 . . PUNCT ct-9916 106 20 gaughan gaughan PROPN ct-9916 106 21 kr kr PROPN ct-9916 106 22 , , PUNCT ct-9916 106 23 bruyette bruyette PROPN ct-9916 106 24 ds ds PROPN ct-9916 106 25 : : PUNCT ct-9916 106 26 thyroid thyroid NOUN ct-9916 106 27 function function NOUN ct-9916 106 28 testing testing NOUN ct-9916 106 29 in in ADP ct-9916 106 30 greyhounds greyhound NOUN ct-9916 106 31 . . PUNCT ct-9916 107 1 am be AUX ct-9916 107 2 j j PROPN ct-9916 107 3 vet vet NOUN ct-9916 107 4 res re NOUN ct-9916 107 5 2001;62:1130–1133 2001;62:1130–1133 PROPN ct-9916 107 6 . . PUNCT ct-9916 108 1 doi doi NOUN ct-9916 108 2 : : PUNCT ct-9916 108 3 10.2460 10.2460 NUM ct-9916 108 4 / / SYM ct-9916 108 5 ajvr.2001.62.1130 ajvr.2001.62.1130 PROPN ct-9916 108 6 9 9 NUM ct-9916 108 7 . . X ct-9916 109 1 shiel shiel PROPN ct-9916 109 2 re re PROPN ct-9916 109 3 , , PUNCT ct-9916 109 4 sist sist PROPN ct-9916 109 5 m m PROPN ct-9916 109 6 , , PUNCT ct-9916 109 7 nachreiner nachreiner PROPN ct-9916 109 8 rf rf NOUN ct-9916 109 9 , , PUNCT ct-9916 109 10 et et PROPN ct-9916 109 11 al al PROPN ct-9916 109 12 : : PUNCT ct-9916 109 13 assessment assessment NOUN ct-9916 109 14 of of ADP ct-9916 109 15 criteria criterion NOUN ct-9916 109 16 used use VERB ct-9916 109 17 by by ADP ct-9916 109 18 veterinary veterinary ADJ ct-9916 109 19 practitioners practitioner NOUN ct-9916 109 20 to to PART ct-9916 109 21 diagnose diagnose VERB ct-9916 109 22 hypothyroidism hypothyroidism NOUN ct-9916 109 23 in in ADP ct-9916 109 24 sighthounds sighthound NOUN ct-9916 109 25 and and CCONJ ct-9916 109 26 investigation investigation NOUN ct-9916 109 27 of of ADP ct-9916 109 28 serum serum PROPN ct-9916 109 29 thyroid thyroid PROPN ct-9916 109 30 hormone hormone NOUN ct-9916 109 31 concentrations concentration NOUN ct-9916 109 32 in in ADP ct-9916 109 33 healthy healthy ADJ ct-9916 109 34 salukis saluki NOUN ct-9916 109 35 . . PUNCT ct-9916 110 1 j j PROPN ct-9916 110 2 am be AUX ct-9916 110 3 vet vet NOUN ct-9916 110 4 med med ADJ ct-9916 110 5 assoc assoc PROPN ct-9916 110 6 2010;236:302–308 2010;236:302–308 PROPN ct-9916 110 7 . . PUNCT ct-9916 111 1 doi doi NOUN ct-9916 111 2 : : PUNCT ct-9916 111 3 10.2460 10.2460 NUM ct-9916 111 4 / / SYM ct-9916 111 5 javma.236.3.302 javma.236.3.302 NOUN ct-9916 111 6 10 10 NUM ct-9916 111 7 . . PUNCT ct-9916 112 1 hegstad hegstad NOUN ct-9916 112 2 - - PUNCT ct-9916 112 3 davies davy NOUN ct-9916 112 4 rl rl PROPN ct-9916 112 5 , , PUNCT ct-9916 112 6 torres torre VERB ct-9916 112 7 sm sm PROPN ct-9916 112 8 , , PUNCT ct-9916 112 9 sharkey sharkey PROPN ct-9916 112 10 lc lc PROPN ct-9916 112 11 , , PUNCT ct-9916 112 12 et et PROPN ct-9916 112 13 al al PROPN ct-9916 112 14 : : PUNCT ct-9916 112 15 breed breed NOUN ct-9916 112 16 - - PUNCT ct-9916 112 17 specific specific ADJ ct-9916 112 18 reference reference NOUN ct-9916 112 19 intervals interval NOUN ct-9916 112 20 for for ADP ct-9916 112 21 assessing assess VERB ct-9916 112 22 thyroid thyroid NOUN ct-9916 112 23 function function NOUN ct-9916 112 24 in in ADP ct-9916 112 25 seven seven NUM ct-9916 112 26 dog dog NOUN ct-9916 112 27 breeds breed NOUN ct-9916 112 28 . . PUNCT ct-9916 113 1 j j PROPN ct-9916 113 2 vet vet PROPN ct-9916 113 3 diagn diagn PROPN ct-9916 113 4 invest invest VERB ct-9916 113 5 2015;27:716–727 2015;27:716–727 NUM ct-9916 113 6 . . PUNCT ct-9916 114 1 doi doi NOUN ct-9916 114 2 : : PUNCT ct-9916 114 3 10.1177/1040638715606953 10.1177/1040638715606953 NUM ct-9916 114 4 11 11 NUM ct-9916 114 5 . . PUNCT ct-9916 115 1 panakova panakova PROPN ct-9916 115 2 l l PROPN ct-9916 115 3 , , PUNCT ct-9916 115 4 koch koch PROPN ct-9916 115 5 h h PROPN ct-9916 115 6 , , PUNCT ct-9916 115 7 kolb kolb PROPN ct-9916 115 8 s s PROPN ct-9916 115 9 , , PUNCT ct-9916 115 10 et et PROPN ct-9916 115 11 al al PROPN ct-9916 115 12 : : PUNCT ct-9916 115 13 thyroid thyroid NOUN ct-9916 115 14 testing testing NOUN ct-9916 115 15 in in ADP ct-9916 115 16 sloughis sloughis NOUN ct-9916 115 17 . . PUNCT ct-9916 115 18     SPACE ct-9916 116 1 j j PROPN ct-9916 116 2     SPACE ct-9916 116 3 vet vet NOUN ct-9916 116 4     SPACE ct-9916 116 5 intern intern NOUN ct-9916 116 6 med med ADJ ct-9916 116 7 2008;22:1144–1148 2008;22:1144–1148 NOUN ct-9916 116 8 . . PUNCT ct-9916 117 1 doi doi NOUN ct-9916 117 2 : : PUNCT ct-9916 117 3 10.1111/ 10.1111/ NUM ct-9916 117 4 j.1939 j.1939 PROPN ct-9916 117 5 - - PUNCT ct-9916 117 6 1676.2008.0155.x 1676.2008.0155.x NUM ct-9916 117 7 12 12 NUM ct-9916 117 8 . . PUNCT ct-9916 118 1 graham graham PROPN ct-9916 118 2 pa pa PROPN ct-9916 118 3 , , PUNCT ct-9916 118 4 refsal refsal NOUN ct-9916 118 5 kr kr PROPN ct-9916 118 6 , , PUNCT ct-9916 118 7 nachreiner nachreiner PROPN ct-9916 118 8 rf rf NOUN ct-9916 118 9 : : PUNCT ct-9916 118 10 etiopathologic etiopathologic ADJ ct-9916 118 11 findings finding NOUN ct-9916 118 12 of of ADP ct-9916 118 13 canine canine PROPN ct-9916 118 14 hypothyroidism hypothyroidism NOUN ct-9916 118 15 . . PUNCT ct-9916 119 1 vet vet NOUN ct-9916 119 2 clin clin PROPN ct-9916 119 3 north north PROPN ct-9916 119 4 am be AUX ct-9916 119 5 small small ADJ ct-9916 119 6 anim anim NOUN ct-9916 119 7 pract pract PROPN ct-9916 119 8 2007;37:617–631 2007;37:617–631 PROPN ct-9916 119 9 . . PUNCT ct-9916 120 1 doi doi NOUN ct-9916 120 2 : : PUNCT ct-9916 120 3 10.1016 10.1016 NUM ct-9916 120 4 / / SYM ct-9916 120 5 j.cvsm.2007.05.002 j.cvsm.2007.05.002 PROPN ct-9916 120 6 13 13 NUM ct-9916 120 7 . . PUNCT ct-9916 121 1 silva silva PROPN ct-9916 121 2 jf jf PROPN ct-9916 121 3 , , PUNCT ct-9916 121 4 ocarino ocarino PROPN ct-9916 121 5 nm nm PROPN ct-9916 121 6 , , PUNCT ct-9916 121 7 serakides serakide VERB ct-9916 121 8 r r NOUN ct-9916 121 9 : : PUNCT ct-9916 121 10 thyroid thyroid NOUN ct-9916 121 11 hormones hormone NOUN ct-9916 121 12 and and CCONJ ct-9916 121 13 female female ADJ ct-9916 121 14 reproduction reproduction NOUN ct-9916 121 15 . . PUNCT ct-9916 122 1 biol biol PROPN ct-9916 122 2 reprod reprod PROPN ct-9916 122 3 2018;99:907–921 2018;99:907–921 AUX ct-9916 122 4 . . PUNCT ct-9916 123 1 doi doi NOUN ct-9916 123 2 : : PUNCT ct-9916 123 3 10.1093 10.1093 NUM ct-9916 123 4 / / SYM ct-9916 123 5 biolre biolre PROPN ct-9916 123 6 / / SYM ct-9916 123 7 ioy115 ioy115 PROPN ct-9916 123 8 14 14 NUM ct-9916 123 9 . . PUNCT ct-9916 124 1 rao rao PROPN ct-9916 124 2 m m PROPN ct-9916 124 3 , , PUNCT ct-9916 124 4 yang yang PROPN ct-9916 124 5 z z PROPN ct-9916 124 6 , , PUNCT ct-9916 124 7 su su PROPN ct-9916 124 8 c c PROPN ct-9916 124 9 , , PUNCT ct-9916 124 10 et et PROPN ct-9916 124 11 al al PROPN ct-9916 124 12 : : PUNCT ct-9916 124 13 paternal paternal ADJ ct-9916 124 14 subclinical subclinical ADJ ct-9916 124 15 hypothyroidism hypothyroidism NOUN ct-9916 124 16 affects affect VERB ct-9916 124 17 the the DET ct-9916 124 18 clinical clinical ADJ ct-9916 124 19 outcomes outcome NOUN ct-9916 124 20 of of ADP ct-9916 124 21 in in ADP ct-9916 124 22 vitro vitro X ct-9916 124 23 fertilization fertilization NOUN ct-9916 124 24 / / SYM ct-9916 124 25 intracytoplasmic intracytoplasmic ADJ ct-9916 124 26 sperm sperm NOUN ct-9916 124 27 injection injection NOUN ct-9916 124 28 . . PUNCT ct-9916 125 1 thyroid thyroid PROPN ct-9916 125 2 2021;31:12–22 2021;31:12–22 NUM ct-9916 125 3 . . PUNCT ct-9916 126 1 doi doi NOUN ct-9916 126 2 : : PUNCT ct-9916 126 3 10.1089/ 10.1089/ NUM ct-9916 126 4 thy.2020.0154 thy.2020.0154 NUM ct-9916 126 5 15 15 NUM ct-9916 126 6 . . PUNCT ct-9916 127 1 monaghan monaghan PROPN ct-9916 127 2 am am PROPN ct-9916 127 3 , , PUNCT ct-9916 127 4 mulhern mulhern PROPN ct-9916 127 5 ms ms PROPN ct-9916 127 6 , , PUNCT ct-9916 127 7 mc mc PROPN ct-9916 127 8 sorley sorley PROPN ct-9916 127 9 em em PRON ct-9916 127 10 , , PUNCT ct-9916 127 11 et et PROPN ct-9916 127 12 al al PROPN ct-9916 127 13 : : PUNCT ct-9916 127 14 associations association NOUN ct-9916 127 15 between between ADP ct-9916 127 16 maternal maternal ADJ ct-9916 127 17 thyroid thyroid NOUN ct-9916 127 18 function function NOUN ct-9916 127 19 in in ADP ct-9916 127 20 pregnancy pregnancy NOUN ct-9916 127 21 and and CCONJ ct-9916 127 22 child child NOUN ct-9916 127 23 neurodevelopmental neurodevelopmental ADJ ct-9916 127 24 outcomes outcome NOUN ct-9916 127 25 at at ADP ct-9916 127 26 20 20 NUM ct-9916 127 27 months month NOUN ct-9916 127 28 in in ADP ct-9916 127 29 the the DET ct-9916 127 30 seychelles seychelles PROPN ct-9916 127 31 child child NOUN ct-9916 127 32 development development PROPN ct-9916 127 33 study study PROPN ct-9916 127 34 , , PUNCT ct-9916 127 35 nutrition nutrition NOUN ct-9916 127 36 cohort cohort NOUN ct-9916 127 37 2 2 NUM ct-9916 127 38 ( ( PUNCT ct-9916 127 39 scds scds PROPN ct-9916 127 40 nc2 nc2 NOUN ct-9916 127 41 ) ) PUNCT ct-9916 127 42 . . PUNCT ct-9916 128 1 j j PROPN ct-9916 128 2 nutr nutr PROPN ct-9916 128 3 sci sci PROPN ct-9916 128 4 2021;10 2021;10 PROPN ct-9916 128 5 : : PUNCT ct-9916 128 6 e71 e71 NOUN ct-9916 128 7 . . PUNCT ct-9916 129 1 doi doi NOUN ct-9916 129 2 : : PUNCT ct-9916 129 3 10.1017 10.1017 NUM ct-9916 129 4 / / SYM ct-9916 129 5 jns.2021.66 jns.2021.66 NUM ct-9916 129 6 16 16 NUM ct-9916 129 7 . . PUNCT ct-9916 130 1 chen chen PROPN ct-9916 130 2 j j PROPN ct-9916 130 3 , , PUNCT ct-9916 130 4 zhu zhu PROPN ct-9916 130 5 j j PROPN ct-9916 130 6 , , PUNCT ct-9916 130 7 huang huang PROPN ct-9916 130 8 x x PROPN ct-9916 130 9 , , PUNCT ct-9916 130 10 et et PROPN ct-9916 130 11 al al PROPN ct-9916 130 12 : : PUNCT ct-9916 130 13 subclinical subclinical ADJ ct-9916 130 14 hypothyroidism hypothyroidism NOUN ct-9916 130 15 with with ADP ct-9916 130 16 negative negative ADJ ct-9916 130 17 for for ADP ct-9916 130 18 thyroid thyroid NOUN ct-9916 130 19 peroxidase peroxidase NOUN ct-9916 130 20 antibodies antibodie VERB ct-9916 130 21 in in ADP ct-9916 130 22 pregnancy pregnancy NOUN ct-9916 130 23 : : PUNCT ct-9916 130 24 intellectual intellectual ADJ ct-9916 130 25 development development NOUN ct-9916 130 26 of of ADP ct-9916 130 27 offspring offspring NOUN ct-9916 130 28 . . PUNCT ct-9916 131 1 thyroid thyroid PROPN ct-9916 131 2 2022;32:449–458 2022;32:449–458 NOUN ct-9916 131 3 . . PUNCT ct-9916 132 1 doi doi NOUN ct-9916 132 2 : : PUNCT ct-9916 132 3 10.1089 10.1089 NUM ct-9916 132 4 / / SYM ct-9916 132 5 thy.2021.0374 thy.2021.0374 ADP ct-9916 132 6 17 17 NUM ct-9916 132 7 . . PUNCT ct-9916 133 1 cecere cecere PROPN ct-9916 133 2 j j PROPN ct-9916 133 3 , , PUNCT ct-9916 133 4 purswell purswell PROPN ct-9916 133 5 b b PROPN ct-9916 133 6 , , PUNCT ct-9916 133 7 panciera panciera NOUN ct-9916 133 8 d d NOUN ct-9916 133 9 : : PUNCT ct-9916 133 10 levothyroxine levothyroxine NOUN ct-9916 133 11 supplementation supplementation NOUN ct-9916 133 12 in in ADP ct-9916 133 13 hypothyroid hypothyroid ADJ ct-9916 133 14 bitches bitch NOUN ct-9916 133 15 during during ADP ct-9916 133 16 pregnancy pregnancy NOUN ct-9916 133 17 . . PUNCT ct-9916 134 1 theriogenology theriogenology NOUN ct-9916 134 2 2020;142:48–53 2020;142:48–53 PROPN ct-9916 134 3 . . PUNCT ct-9916 134 4 doi doi PROPN ct-9916 134 5 : : PUNCT ct-9916 134 6 10.1016 10.1016 NUM ct-9916 134 7 / / SYM ct-9916 134 8 j.theriogenology.2019.09.036 j.theriogenology.2019.09.036 PROPN ct-9916 134 9 18 18 NUM ct-9916 134 10 . . PUNCT ct-9916 135 1 johnson johnson PROPN ct-9916 135 2 ca can AUX ct-9916 135 3 : : PUNCT ct-9916 135 4 thyroid thyroid VERB ct-9916 135 5 issues issue NOUN ct-9916 135 6 in in ADP ct-9916 135 7 reproduction reproduction NOUN ct-9916 135 8 . . PUNCT ct-9916 136 1 clin clin PROPN ct-9916 136 2 tech tech PROPN ct-9916 136 3 small small PROPN ct-9916 136 4 anim anim NOUN ct-9916 136 5 pract pract NOUN ct-9916 136 6 2002;17:129–132 2002;17:129–132 PROPN ct-9916 136 7 . . PUNCT ct-9916 137 1 doi doi NOUN ct-9916 137 2 : : PUNCT ct-9916 137 3 10.1053 10.1053 NUM ct-9916 137 4 / / SYM ct-9916 137 5 svms.2002.34643 svms.2002.34643 PROPN ct-9916 137 6 19 19 NUM ct-9916 137 7 . . PUNCT ct-9916 138 1 david david PROPN ct-9916 138 2 lp lp PROPN ct-9916 138 3 : : PUNCT ct-9916 138 4 conditions condition NOUN ct-9916 138 5 associated associate VERB ct-9916 138 6 with with ADP ct-9916 138 7 canine canine NOUN ct-9916 138 8 hypothyroidism hypothyroidism NOUN ct-9916 138 9 . . PUNCT ct-9916 139 1 vet vet NOUN ct-9916 139 2 clin clin PROPN ct-9916 139 3 small small PROPN ct-9916 139 4 am be AUX ct-9916 139 5 pract pract PROPN ct-9916 139 6 2001;31:935–950 2001;31:935–950 PROPN ct-9916 139 7 . . PUNCT ct-9916 140 1 doi doi NOUN ct-9916 140 2 : : PUNCT ct-9916 140 3 10.1016/ 10.1016/ NUM ct-9916 140 4 s0195 s0195 PROPN ct-9916 140 5 - - ADJ ct-9916 140 6 5616(01)50006 5616(01)50006 NUM ct-9916 140 7 - - PUNCT ct-9916 140 8 6 6 NUM ct-9916 140 9 20 20 NUM ct-9916 140 10 . . PUNCT ct-9916 141 1 wilborn wilborn VERB ct-9916 141 2 rr rr PROPN ct-9916 141 3 , , PUNCT ct-9916 141 4 maxwell maxwell PROPN ct-9916 141 5 hs hs PROPN ct-9916 141 6 : : PUNCT ct-9916 141 7 clinical clinical ADJ ct-9916 141 8 approaches approach NOUN ct-9916 141 9 to to ADP ct-9916 141 10 infertility infertility NOUN ct-9916 141 11 in in ADP ct-9916 141 12 the the DET ct-9916 141 13 bitch bitch NOUN ct-9916 141 14 . . PUNCT ct-9916 142 1 vet vet NOUN ct-9916 142 2 clin clin PROPN ct-9916 142 3 small small PROPN ct-9916 142 4 am be AUX ct-9916 142 5 pract pract NOUN ct-9916 142 6 2012;42:457–468 2012;42:457–468 NUM ct-9916 142 7 . . PUNCT ct-9916 143 1 doi doi NOUN ct-9916 143 2 : : PUNCT ct-9916 143 3 10.1016 10.1016 NUM ct-9916 143 4 / / SYM ct-9916 143 5 j. j. PROPN ct-9916 143 6 cvsm.2012.01.016 cvsm.2012.01.016 PROPN ct-9916 143 7 21 21 NUM ct-9916 143 8 . . PUNCT ct-9916 144 1 panciera panciera NOUN ct-9916 144 2 d d NOUN ct-9916 144 3 , , PUNCT ct-9916 144 4 purswell purswell PROPN ct-9916 144 5 b b PROPN ct-9916 144 6 , , PUNCT ct-9916 144 7 kolster kolster ADJ ct-9916 144 8 k k NOUN ct-9916 144 9 : : PUNCT ct-9916 144 10 effect effect NOUN ct-9916 144 11 of of ADP ct-9916 144 12 short short ADJ ct-9916 144 13 - - PUNCT ct-9916 144 14 term term NOUN ct-9916 144 15 hypothyroidism hypothyroidism NOUN ct-9916 144 16 on on ADP ct-9916 144 17 reproduction reproduction NOUN ct-9916 144 18 in in ADP ct-9916 144 19 the the DET ct-9916 144 20 bitch bitch NOUN ct-9916 144 21 . . PUNCT ct-9916 145 1 theriogenology theriogenology NOUN ct-9916 145 2 2007;68:316–321 2007;68:316–321 PROPN ct-9916 145 3 . . PUNCT ct-9916 146 1 doi doi NOUN ct-9916 146 2 : : PUNCT ct-9916 146 3 10.1016 10.1016 NUM ct-9916 146 4 / / SYM ct-9916 146 5 j.theriogenology.2007.04.026 j.theriogenology.2007.04.026 PROPN ct-9916 146 6 22 22 NUM ct-9916 146 7 . . PUNCT ct-9916 147 1 panciera panciera NOUN ct-9916 147 2 d d NOUN ct-9916 147 3 , , PUNCT ct-9916 147 4 purswell purswell PROPN ct-9916 147 5 b b PROPN ct-9916 147 6 , , PUNCT ct-9916 147 7 kolster kolster PROPN ct-9916 147 8 k k PROPN ct-9916 147 9 , , PUNCT ct-9916 147 10 et et PROPN ct-9916 147 11 al al PROPN ct-9916 147 12 : : PUNCT ct-9916 147 13 reproductive reproductive ADJ ct-9916 147 14 effects effect NOUN ct-9916 147 15 of of ADP ct-9916 147 16 prolonged prolonged ADJ ct-9916 147 17 experimentally experimentally ADV ct-9916 147 18 induced induce VERB ct-9916 147 19 hypothyroidism hypothyroidism NOUN ct-9916 147 20 in in ADP ct-9916 147 21 bitches bitch NOUN ct-9916 147 22 . . PUNCT ct-9916 148 1 j j PROPN ct-9916 148 2 vet vet NOUN ct-9916 148 3 intern intern NOUN ct-9916 148 4 med med ADJ ct-9916 148 5 2012;26:326–333 2012;26:326–333 NOUN ct-9916 148 6 . . PUNCT ct-9916 149 1 doi doi NOUN ct-9916 149 2 : : PUNCT ct-9916 149 3 10.1111/ 10.1111/ NUM ct-9916 149 4 j.1939 j.1939 PROPN ct-9916 149 5 - - PUNCT ct-9916 149 6 1676.2011.00872.x 1676.2011.00872.x NUM ct-9916 149 7 23 23 NUM ct-9916 149 8 . . PUNCT ct-9916 150 1 thuróczy thuróczy PROPN ct-9916 151 1 j j PROPN ct-9916 151 2 , , PUNCT ct-9916 151 3 müller müller PROPN ct-9916 151 4 l l PROPN ct-9916 151 5 , , PUNCT ct-9916 151 6 kollár kollár PROPN ct-9916 151 7 e e NOUN ct-9916 151 8 , , PUNCT ct-9916 151 9 et et PROPN ct-9916 151 10 al al PROPN ct-9916 151 11 : : PUNCT ct-9916 151 12 thyroxin thyroxin NOUN ct-9916 151 13 and and CCONJ ct-9916 151 14 progesterone progesterone NOUN ct-9916 151 15 concentrations concentration NOUN ct-9916 151 16 in in ADP ct-9916 151 17 pregnant pregnant ADJ ct-9916 151 18 , , PUNCT ct-9916 151 19 nonpregnant nonpregnant ADJ ct-9916 151 20 bitches bitch NOUN ct-9916 151 21 , , PUNCT ct-9916 151 22 and and CCONJ ct-9916 151 23 bitches bitch NOUN ct-9916 151 24 during during ADP ct-9916 151 25 abortion abortion NOUN ct-9916 151 26 . . PUNCT ct-9916 152 1 theriogenology theriogenology NOUN ct-9916 152 2 2016;85:1186–1191 2016;85:1186–1191 PROPN ct-9916 152 3 . . PUNCT ct-9916 153 1 doi doi PROPN ct-9916 153 2 : : PUNCT ct-9916 153 3 10.1016 10.1016 NUM ct-9916 153 4 / / SYM ct-9916 153 5 j. j. PROPN ct-9916 153 6 theriogenology.2015.11.035 theriogenology.2015.11.035 PROPN ct-9916 154 1 24 24 NUM ct-9916 154 2 . . PUNCT ct-9916 155 1 conaway conaway PROPN ct-9916 155 2 d d PROPN ct-9916 155 3 , , PUNCT ct-9916 155 4 padgett padgett PROPN ct-9916 155 5 g g PROPN ct-9916 155 6 , , PUNCT ct-9916 155 7 bunton bunton PROPN ct-9916 155 8 t t PROPN ct-9916 155 9 , , PUNCT ct-9916 155 10 et et PROPN ct-9916 155 11 al al PROPN ct-9916 155 12 : : PUNCT ct-9916 155 13 clinical clinical ADJ ct-9916 155 14 and and CCONJ ct-9916 155 15 histological histological ADJ ct-9916 155 16 features feature NOUN ct-9916 155 17 of of ADP ct-9916 155 18 primary primary ADJ ct-9916 155 19 progressive progressive ADJ ct-9916 155 20 , , PUNCT ct-9916 155 21 familial familial ADJ ct-9916 155 22 thyroiditis thyroiditis NOUN ct-9916 155 23 in in ADP ct-9916 155 24 a a DET ct-9916 155 25 colony colony NOUN ct-9916 155 26 of of ADP ct-9916 155 27     SPACE ct-9916 155 28 borzoi borzoi VERB ct-9916 155 29 dogs dog NOUN ct-9916 155 30 . . PUNCT ct-9916 156 1 vet vet NOUN ct-9916 156 2 pathol pathol NOUN ct-9916 156 3 1985;22:439–446 1985;22:439–446 PROPN ct-9916 156 4 . . PUNCT ct-9916 157 1 doi doi NOUN ct-9916 157 2 : : PUNCT ct-9916 157 3 10.1177/ 10.1177/ PROPN ct-9916 157 4 030098588502200502 030098588502200502 NUM ct-9916 157 5 25 25 NUM ct-9916 157 6 . . PUNCT ct-9916 158 1 johnson johnson PROPN ct-9916 158 2 c c PROPN ct-9916 158 3 , , PUNCT ct-9916 158 4 nachreiner nachreiner ADJ ct-9916 158 5 r r NOUN ct-9916 158 6 , , PUNCT ct-9916 158 7 mullaney mullaney NOUN ct-9916 158 8 t t PROPN ct-9916 158 9 , , PUNCT ct-9916 158 10 et et PROPN ct-9916 158 11 al al PROPN ct-9916 158 12 : : PUNCT ct-9916 158 13 reproductive reproductive ADJ ct-9916 158 14 manifestations manifestation NOUN ct-9916 158 15 of of ADP ct-9916 158 16 hypothyroidism hypothyroidism NOUN ct-9916 158 17 . . PUNCT ct-9916 159 1 santa santa PROPN ct-9916 159 2 barbara barbara PROPN ct-9916 159 3 , , PUNCT ct-9916 159 4 ca can AUX ct-9916 159 5 : : PUNCT ct-9916 159 6 canine canine VERB ct-9916 159 7 practice practice NOUN ct-9916 159 8 , , PUNCT ct-9916 159 9 1997 1997 NUM ct-9916 159 10 , , PUNCT ct-9916 159 11 p. p. NOUN ct-9916 159 12 29–30 29–30 NUM ct-9916 159 13 . . PUNCT ct-9916 160 1 26 26 NUM ct-9916 160 2 . . PUNCT ct-9916 161 1 johnson johnson PROPN ct-9916 161 2 c c PROPN ct-9916 161 3 , , PUNCT ct-9916 161 4 olivier olivier PROPN ct-9916 161 5 nb nb PROPN ct-9916 161 6 , , PUNCT ct-9916 161 7 nachreiner nachreiner ADJ ct-9916 161 8 r r NOUN ct-9916 161 9 , , PUNCT ct-9916 161 10 et et PROPN ct-9916 161 11 al al PROPN ct-9916 161 12 : : PUNCT ct-9916 161 13 effect effect NOUN ct-9916 161 14 of of ADP ct-9916 161 15 131 131 NUM ct-9916 161 16 i i ADV ct-9916 161 17 - - PUNCT ct-9916 161 18 induced induce VERB ct-9916 161 19 hypothyroidism hypothyroidism NOUN ct-9916 161 20 on on ADP ct-9916 161 21 indices index NOUN ct-9916 161 22 of of ADP ct-9916 161 23 reproductive reproductive ADJ ct-9916 161 24 function function NOUN ct-9916 161 25 in in ADP ct-9916 161 26 adult adult NOUN ct-9916 161 27 male male ADJ ct-9916 161 28 dogs dog NOUN ct-9916 161 29 . . PUNCT ct-9916 162 1 j j PROPN ct-9916 162 2 vet vet NOUN ct-9916 162 3 intern intern NOUN ct-9916 162 4 med med PROPN ct-9916 162 5 1999;13:104–110 1999;13:104–110 PROPN ct-9916 162 6 . . PUNCT ct-9916 163 1 doi doi NOUN ct-9916 163 2 : : PUNCT ct-9916 163 3 10.1111 10.1111 NUM ct-9916 163 4 / / SYM ct-9916 163 5 j.1939 j.1939 PROPN ct-9916 163 6 - - PUNCT ct-9916 163 7 1676.1999.tb01137.x 1676.1999.tb01137.x NUM ct-9916 163 8 http://dx.doi.org/10.58292/ct.v15.9916 http://dx.doi.org/10.58292/ct.v15.9916 PROPN ct-9916 163 9 https://doi.org/10.2460/ajvr.2001.62.1130 https://doi.org/10.2460/ajvr.2001.62.1130 SYM ct-9916 163 10 https://doi.org/10.2460/javma.236.3.302 https://doi.org/10.2460/javma.236.3.302 NOUN ct-9916 163 11 https://doi.org/10.1177/1040638715606953 https://doi.org/10.1177/1040638715606953 ADP ct-9916 163 12 https://doi.org/10.1111/​j.1939-1676.2008.0155.x https://doi.org/10.1111/​j.1939-1676.2008.0155.x PROPN ct-9916 163 13 https://doi.org/10.1111/​j.1939-1676.2008.0155.x https://doi.org/10.1111/​j.1939-1676.2008.0155.x PROPN ct-9916 163 14 https://doi.org/10.1016/j.cvsm.2007.05.002 https://doi.org/10.1016/j.cvsm.2007.05.002 PROPN ct-9916 163 15 https://doi.org/10.1093/biolre/ioy115 https://doi.org/10.1093/biolre/ioy115 NOUN ct-9916 163 16 https://doi.org/10.1089/thy.2020.0154 https://doi.org/10.1089/thy.2020.0154 VERB ct-9916 163 17 https://doi.org/10.1089/thy.2020.0154 https://doi.org/10.1089/thy.2020.0154 PROPN ct-9916 163 18 https://doi.org/10.1017/jns.2021.66 https://doi.org/10.1017/jns.2021.66 NOUN ct-9916 163 19 https://doi.org/10.1089/thy.2021.0374 https://doi.org/10.1089/thy.2021.0374 ADJ ct-9916 163 20 https://doi.org/10.1016/j.theriogenology.2019.09.036 https://doi.org/10.1016/j.theriogenology.2019.09.036 NOUN ct-9916 164 1 https://doi.org/10.1053/svms.2002.34643 https://doi.org/10.1053/svms.2002.34643 PROPN ct-9916 164 2 https://doi.org/10.1016/s0195-5616(01)50006-6 https://doi.org/10.1016/s0195-5616(01)50006-6 AUX ct-9916 164 3 https://doi.org/10.1016/s0195-5616(01)50006-6 https://doi.org/10.1016/s0195-5616(01)50006-6 VERB ct-9916 164 4 https://doi.org/10.1016/j.cvsm.2012.01.016 https://doi.org/10.1016/j.cvsm.2012.01.016 NOUN ct-9916 164 5 https://doi.org/10.1016/j.cvsm.2012.01.016 https://doi.org/10.1016/j.cvsm.2012.01.016 PROPN ct-9916 164 6 https://doi.org/10.1016/j.theriogenology.2007.04.026 https://doi.org/10.1016/j.theriogenology.2007.04.026 PROPN ct-9916 164 7 https://doi.org/10.1111/j.1939-1676.2011.00872.x https://doi.org/10.1111/j.1939-1676.2011.00872.x NOUN ct-9916 164 8 https://doi.org/10.1016/j.theriogenology.2015.11.035 https://doi.org/10.1016/j.theriogenology.2015.11.035 NOUN ct-9916 164 9 https://doi.org/10.1016/j.theriogenology.2015.11.035 https://doi.org/10.1016/j.theriogenology.2015.11.035 NOUN ct-9916 164 10 https://doi.org/10.1177/030098588502200502 https://doi.org/10.1177/030098588502200502 NUM ct-9916 164 11 https://doi.org/10.1177/030098588502200502 https://doi.org/10.1177/030098588502200502 VERB ct-9916 164 12 https://doi.org/10.1111/j.1939-1676.1999.tb01137.x https://doi.org/10.1111/j.1939-1676.1999.tb01137.x PUNCT