id	sid	tid	token	lemma	pos
ct-9922	1	1	2018	2018	NUM
ct-9922	1	2	:	:	PUNCT
ct-9922	1	3	application	application	NOUN
ct-9922	1	4	of	of	ADP
ct-9922	1	5	gene	gene	NOUN
ct-9922	1	6	-	-	PUNCT
ct-9922	1	7	editing	editing	NOUN
ct-9922	1	8	in	in	ADP
ct-9922	1	9	livestock	livestock	NOUN
ct-9922	1	10	?	?	PUNCT
ct-9922	2	1	updates	update	NOUN
ct-9922	2	2	and	and	CCONJ
ct-9922	2	3	prospects	prospect	VERB
ct-9922	2	4	application	application	NOUN
ct-9922	2	5	of	of	ADP
ct-9922	2	6	gene	gene	NOUN
ct-9922	2	7	-	-	PUNCT
ct-9922	2	8	editing	editing	NOUN
ct-9922	2	9	in	in	ADP
ct-9922	2	10	livestock	livestock	NOUN
ct-9922	2	11	–	–	PUNCT
ct-9922	2	12	updates	update	NOUN
ct-9922	2	13	and	and	CCONJ
ct-9922	2	14	prospects	prospect	NOUN
ct-9922	2	15	kiho	kiho	PROPN
ct-9922	2	16	lee	lee	PROPN
ct-9922	2	17	,	,	PUNCT
ct-9922	2	18	kyungjun	kyungjun	PROPN
ct-9922	2	19	uh	uh	INTJ
ct-9922	2	20	,	,	PUNCT
ct-9922	2	21	junghyun	junghyun	PROPN
ct-9922	2	22	ryu	ryu	PROPN
ct-9922	2	23	department	department	PROPN
ct-9922	2	24	of	of	ADP
ct-9922	2	25	animal	animal	NOUN
ct-9922	2	26	and	and	CCONJ
ct-9922	2	27	poultry	poultry	NOUN
ct-9922	2	28	sciences	sciences	PROPN
ct-9922	2	29	,	,	PUNCT
ct-9922	2	30	virginia	virginia	PROPN
ct-9922	2	31	tech	tech	PROPN
ct-9922	2	32	,	,	PUNCT
ct-9922	2	33	blacksburg	blacksburg	PROPN
ct-9922	2	34	,	,	PUNCT
ct-9922	2	35	va	va	NOUN
ct-9922	2	36	introduction	introduction	NOUN
ct-9922	2	37	genetic	genetic	ADJ
ct-9922	2	38	improvements	improvement	NOUN
ct-9922	2	39	are	be	AUX
ct-9922	2	40	essential	essential	ADJ
ct-9922	2	41	for	for	ADP
ct-9922	2	42	sustainable	sustainable	ADJ
ct-9922	2	43	production	production	NOUN
ct-9922	2	44	in	in	ADP
ct-9922	2	45	livestock	livestock	NOUN
ct-9922	2	46	.	.	PUNCT
ct-9922	3	1	traditionally	traditionally	ADV
ct-9922	3	2	,	,	PUNCT
ct-9922	3	3	genetic	genetic	ADJ
ct-9922	3	4	selection	selection	NOUN
ct-9922	3	5	has	have	AUX
ct-9922	3	6	been	be	AUX
ct-9922	3	7	based	base	VERB
ct-9922	3	8	on	on	ADP
ct-9922	3	9	phenotypes	phenotype	NOUN
ct-9922	3	10	related	relate	VERB
ct-9922	3	11	to	to	ADP
ct-9922	3	12	efficient	efficient	ADJ
ct-9922	3	13	production	production	NOUN
ct-9922	3	14	or	or	CCONJ
ct-9922	3	15	economically	economically	ADV
ct-9922	3	16	valuable	valuable	ADJ
ct-9922	3	17	traits	trait	NOUN
ct-9922	3	18	;	;	PUNCT
ct-9922	3	19	livestock	livestock	NOUN
ct-9922	3	20	has	have	AUX
ct-9922	3	21	been	be	AUX
ct-9922	3	22	bred	breed	VERB
ct-9922	3	23	for	for	SCONJ
ct-9922	3	24	these	these	DET
ct-9922	3	25	traits	trait	NOUN
ct-9922	3	26	to	to	PART
ct-9922	3	27	enhance	enhance	VERB
ct-9922	3	28	profit	profit	NOUN
ct-9922	3	29	.	.	PUNCT
ct-9922	4	1	for	for	ADP
ct-9922	4	2	instance	instance	NOUN
ct-9922	4	3	,	,	PUNCT
ct-9922	4	4	cattle	cattle	NOUN
ct-9922	4	5	have	have	AUX
ct-9922	4	6	been	be	AUX
ct-9922	4	7	selectively	selectively	ADV
ct-9922	4	8	bred	breed	VERB
ct-9922	4	9	to	to	PART
ct-9922	4	10	produce	produce	VERB
ct-9922	4	11	more	more	ADJ
ct-9922	4	12	meat	meat	NOUN
ct-9922	4	13	or	or	CCONJ
ct-9922	4	14	more	more	ADJ
ct-9922	4	15	milk	milk	NOUN
ct-9922	4	16	,	,	PUNCT
ct-9922	4	17	and	and	CCONJ
ct-9922	4	18	pigs	pig	NOUN
ct-9922	4	19	have	have	AUX
ct-9922	4	20	been	be	AUX
ct-9922	4	21	crossed	cross	VERB
ct-9922	4	22	to	to	PART
ct-9922	4	23	improve	improve	VERB
ct-9922	4	24	productivity	productivity	NOUN
ct-9922	4	25	,	,	PUNCT
ct-9922	4	26	reproductive	reproductive	ADJ
ct-9922	4	27	traits	trait	NOUN
ct-9922	4	28	,	,	PUNCT
ct-9922	4	29	and	and	CCONJ
ct-9922	4	30	resistance	resistance	NOUN
ct-9922	4	31	to	to	ADP
ct-9922	4	32	diseases	disease	NOUN
ct-9922	4	33	.	.	PUNCT
ct-9922	5	1	these	these	DET
ct-9922	5	2	breeding	breeding	NOUN
ct-9922	5	3	programs	program	NOUN
ct-9922	5	4	have	have	AUX
ct-9922	5	5	utilized	utilize	VERB
ct-9922	5	6	the	the	DET
ct-9922	5	7	natural	natural	ADJ
ct-9922	5	8	genetic	genetic	ADJ
ct-9922	5	9	variation	variation	NOUN
ct-9922	5	10	present	present	ADJ
ct-9922	5	11	in	in	ADP
ct-9922	5	12	an	an	DET
ct-9922	5	13	animal	animal	NOUN
ct-9922	5	14	population	population	NOUN
ct-9922	5	15	.	.	PUNCT
ct-9922	6	1	on	on	ADP
ct-9922	6	2	the	the	DET
ct-9922	6	3	other	other	ADJ
ct-9922	6	4	hand	hand	NOUN
ct-9922	6	5	,	,	PUNCT
ct-9922	6	6	genetic	genetic	ADJ
ct-9922	6	7	engineering	engineering	NOUN
ct-9922	6	8	technology	technology	NOUN
ct-9922	6	9	can	can	AUX
ct-9922	6	10	precisely	precisely	ADV
ct-9922	6	11	modify	modify	VERB
ct-9922	6	12	a	a	DET
ct-9922	6	13	genome	genome	NOUN
ct-9922	6	14	to	to	PART
ct-9922	6	15	improve	improve	VERB
ct-9922	6	16	genetic	genetic	ADJ
ct-9922	6	17	value	value	NOUN
ct-9922	6	18	of	of	ADP
ct-9922	6	19	livestock.1	livestock.1	NOUN
ct-9922	6	20	the	the	DET
ct-9922	6	21	approach	approach	NOUN
ct-9922	6	22	can	can	AUX
ct-9922	6	23	selectively	selectively	ADV
ct-9922	6	24	edit	edit	VERB
ct-9922	6	25	genetic	genetic	ADJ
ct-9922	6	26	traits	trait	NOUN
ct-9922	6	27	without	without	ADP
ct-9922	6	28	segregating	segregate	VERB
ct-9922	6	29	other	other	ADJ
ct-9922	6	30	economically	economically	ADV
ct-9922	6	31	valuable	valuable	ADJ
ct-9922	6	32	traits	trait	NOUN
ct-9922	6	33	seen	see	VERB
ct-9922	6	34	in	in	ADP
ct-9922	6	35	breeding	breeding	NOUN
ct-9922	6	36	-	-	PUNCT
ct-9922	6	37	based	base	VERB
ct-9922	6	38	genetic	genetic	ADJ
ct-9922	6	39	improvements	improvement	NOUN
ct-9922	6	40	;	;	PUNCT
ct-9922	6	41	therefore	therefore	ADV
ct-9922	6	42	,	,	PUNCT
ct-9922	6	43	the	the	DET
ct-9922	6	44	approach	approach	NOUN
ct-9922	6	45	can	can	AUX
ct-9922	6	46	dramatically	dramatically	ADV
ct-9922	6	47	reduce	reduce	VERB
ct-9922	6	48	the	the	DET
ct-9922	6	49	genetic	genetic	ADJ
ct-9922	6	50	value	value	NOUN
ct-9922	6	51	of	of	ADP
ct-9922	6	52	livestock	livestock	NOUN
ct-9922	6	53	with	with	ADP
ct-9922	6	54	a	a	DET
ct-9922	6	55	minimum	minimum	ADJ
ct-9922	6	56	number	number	NOUN
ct-9922	6	57	of	of	ADP
ct-9922	6	58	breedings	breeding	NOUN
ct-9922	6	59	.	.	PUNCT
ct-9922	7	1	success	success	NOUN
ct-9922	7	2	of	of	ADP
ct-9922	7	3	genetic	genetic	ADJ
ct-9922	7	4	engineering	engineering	NOUN
ct-9922	7	5	in	in	ADP
ct-9922	7	6	livestock	livestock	NOUN
ct-9922	7	7	has	have	AUX
ct-9922	7	8	been	be	AUX
ct-9922	7	9	historically	historically	ADV
ct-9922	7	10	low	low	ADJ
ct-9922	7	11	due	due	ADJ
ct-9922	7	12	to	to	ADP
ct-9922	7	13	technical	technical	ADJ
ct-9922	7	14	challenges	challenge	NOUN
ct-9922	7	15	.	.	PUNCT
ct-9922	8	1	however	however	ADV
ct-9922	8	2	,	,	PUNCT
ct-9922	8	3	the	the	DET
ct-9922	8	4	recent	recent	ADJ
ct-9922	8	5	development	development	NOUN
ct-9922	8	6	of	of	ADP
ct-9922	8	7	gene	gene	NOUN
ct-9922	8	8	-	-	PUNCT
ct-9922	8	9	editing	edit	VERB
ct-9922	8	10	technology	technology	NOUN
ct-9922	8	11	allows	allow	VERB
ct-9922	8	12	these	these	DET
ct-9922	8	13	modifications	modification	NOUN
ct-9922	8	14	to	to	PART
ct-9922	8	15	be	be	AUX
ct-9922	8	16	highly	highly	ADV
ct-9922	8	17	efficient.2	efficient.2	ADJ
ct-9922	8	18	historical	historical	ADJ
ct-9922	8	19	approach	approach	NOUN
ct-9922	8	20	of	of	ADP
ct-9922	8	21	genetic	genetic	ADJ
ct-9922	8	22	engineering	engineering	NOUN
ct-9922	8	23	the	the	DET
ct-9922	8	24	first	first	ADJ
ct-9922	8	25	report	report	NOUN
ct-9922	8	26	of	of	ADP
ct-9922	8	27	genetic	genetic	ADJ
ct-9922	8	28	engineering	engineering	NOUN
ct-9922	8	29	in	in	ADP
ct-9922	8	30	mammals	mammal	NOUN
ct-9922	8	31	was	be	AUX
ct-9922	8	32	in	in	ADP
ct-9922	8	33	1976	1976	NUM
ct-9922	8	34	by	by	ADP
ct-9922	8	35	introducing	introduce	VERB
ct-9922	8	36	exogenous	exogenous	ADJ
ct-9922	8	37	moloney	moloney	PROPN
ct-9922	8	38	leukemia	leukemia	NOUN
ct-9922	8	39	virus	virus	NOUN
ct-9922	8	40	(	(	PUNCT
ct-9922	8	41	m	m	NOUN
ct-9922	8	42	-	-	ADJ
ct-9922	8	43	mulv	mulv	ADJ
ct-9922	8	44	)	)	PUNCT
ct-9922	8	45	into	into	ADP
ct-9922	8	46	a	a	DET
ct-9922	8	47	mouse	mouse	NOUN
ct-9922	8	48	genome	genome	NOUN
ct-9922	8	49	and	and	CCONJ
ct-9922	8	50	transmitting	transmit	VERB
ct-9922	8	51	it	it	PRON
ct-9922	8	52	to	to	ADP
ct-9922	8	53	its	its	PRON
ct-9922	8	54	offspring.3	offspring.3	PROPN
ct-9922	8	55	engineering	engineering	NOUN
ct-9922	8	56	of	of	ADP
ct-9922	8	57	these	these	DET
ct-9922	8	58	viral	viral	ADJ
ct-9922	8	59	vector	vector	NOUN
ct-9922	8	60	systems	system	NOUN
ct-9922	8	61	allowed	allow	VERB
ct-9922	8	62	us	we	PRON
ct-9922	8	63	to	to	PART
ct-9922	8	64	deliver	deliver	VERB
ct-9922	8	65	exogenous	exogenous	ADJ
ct-9922	8	66	dna	dna	NOUN
ct-9922	8	67	into	into	ADP
ct-9922	8	68	livestock	livestock	NOUN
ct-9922	8	69	genomes	genome	NOUN
ct-9922	8	70	as	as	ADP
ct-9922	8	71	a	a	DET
ct-9922	8	72	form	form	NOUN
ct-9922	8	73	of	of	ADP
ct-9922	8	74	transgenesis	transgenesis	NOUN
ct-9922	8	75	including	include	VERB
ct-9922	8	76	pigs4	pigs4	NOUN
ct-9922	8	77	and	and	CCONJ
ct-9922	8	78	cattle.5	cattle.5	VERB
ct-9922	8	79	although	although	SCONJ
ct-9922	8	80	successful	successful	ADJ
ct-9922	8	81	,	,	PUNCT
ct-9922	8	82	application	application	NOUN
ct-9922	8	83	of	of	ADP
ct-9922	8	84	the	the	DET
ct-9922	8	85	approach	approach	NOUN
ct-9922	8	86	has	have	AUX
ct-9922	8	87	been	be	AUX
ct-9922	8	88	limited	limit	VERB
ct-9922	8	89	because	because	SCONJ
ct-9922	8	90	of	of	ADP
ct-9922	8	91	difficulties	difficulty	NOUN
ct-9922	8	92	in	in	ADP
ct-9922	8	93	constructing	construct	VERB
ct-9922	8	94	effective	effective	ADJ
ct-9922	8	95	viral	viral	ADJ
ct-9922	8	96	vectors	vector	NOUN
ct-9922	8	97	and	and	CCONJ
ct-9922	8	98	integration	integration	NOUN
ct-9922	8	99	of	of	ADP
ct-9922	8	100	viral	viral	ADJ
ct-9922	8	101	genes	gene	NOUN
ct-9922	8	102	into	into	ADP
ct-9922	8	103	host	host	NOUN
ct-9922	8	104	genomes	genome	NOUN
ct-9922	8	105	.	.	PUNCT
ct-9922	9	1	pronuclear	pronuclear	PROPN
ct-9922	9	2	injection	injection	NOUN
ct-9922	9	3	,	,	PUNCT
ct-9922	9	4	on	on	ADP
ct-9922	9	5	the	the	DET
ct-9922	9	6	other	other	ADJ
ct-9922	9	7	hand	hand	NOUN
ct-9922	9	8	,	,	PUNCT
ct-9922	9	9	is	be	AUX
ct-9922	9	10	technically	technically	ADV
ct-9922	9	11	more	more	ADV
ct-9922	9	12	convenient	convenient	ADJ
ct-9922	9	13	,	,	PUNCT
ct-9922	9	14	and	and	CCONJ
ct-9922	9	15	unlike	unlike	ADP
ct-9922	9	16	virus	virus	NOUN
ct-9922	9	17	-	-	PUNCT
ct-9922	9	18	mediated	mediate	VERB
ct-9922	9	19	transgenesis	transgenesis	NOUN
ct-9922	9	20	,	,	PUNCT
ct-9922	9	21	there	there	PRON
ct-9922	9	22	is	be	VERB
ct-9922	9	23	no	no	DET
ct-9922	9	24	limit	limit	NOUN
ct-9922	9	25	to	to	ADP
ct-9922	9	26	the	the	DET
ct-9922	9	27	size	size	NOUN
ct-9922	9	28	of	of	ADP
ct-9922	9	29	exogenous	exogenous	ADJ
ct-9922	9	30	dna	dna	NOUN
ct-9922	9	31	that	that	PRON
ct-9922	9	32	can	can	AUX
ct-9922	9	33	be	be	AUX
ct-9922	9	34	integrated	integrate	VERB
ct-9922	9	35	into	into	ADP
ct-9922	9	36	the	the	DET
ct-9922	9	37	genome	genome	NOUN
ct-9922	9	38	.	.	PUNCT
ct-9922	10	1	in	in	ADP
ct-9922	10	2	1980	1980	NUM
ct-9922	10	3	,	,	PUNCT
ct-9922	10	4	gordon	gordon	PROPN
ct-9922	10	5	et	et	PROPN
ct-9922	10	6	al.6	al.6	PROPN
ct-9922	10	7	successfully	successfully	ADV
ct-9922	10	8	introduced	introduce	VERB
ct-9922	10	9	exogenous	exogenous	ADJ
ct-9922	10	10	dna	dna	NOUN
ct-9922	10	11	into	into	ADP
ct-9922	10	12	the	the	DET
ct-9922	10	13	mouse	mouse	NOUN
ct-9922	10	14	genome	genome	NOUN
ct-9922	10	15	by	by	ADP
ct-9922	10	16	pronuclear	pronuclear	NOUN
ct-9922	10	17	microinjection	microinjection	NOUN
ct-9922	10	18	.	.	PUNCT
ct-9922	11	1	the	the	DET
ct-9922	11	2	pronuclear	pronuclear	NOUN
ct-9922	11	3	injection	injection	NOUN
ct-9922	11	4	approach	approach	NOUN
ct-9922	11	5	was	be	AUX
ct-9922	11	6	also	also	ADV
ct-9922	11	7	applied	apply	VERB
ct-9922	11	8	to	to	PART
ct-9922	11	9	develop	develop	VERB
ct-9922	11	10	numerous	numerous	ADJ
ct-9922	11	11	transgenic	transgenic	NOUN
ct-9922	11	12	pig	pig	NOUN
ct-9922	11	13	lines7	lines7	NOUN
ct-9922	11	14	-	-	PUNCT
ct-9922	11	15	9	9	NUM
ct-9922	11	16	and	and	CCONJ
ct-9922	11	17	cattle.10	cattle.10	NOUN
ct-9922	11	18	however	however	ADV
ct-9922	11	19	,	,	PUNCT
ct-9922	11	20	this	this	DET
ct-9922	11	21	technique	technique	NOUN
ct-9922	11	22	has	have	VERB
ct-9922	11	23	limitations	limitation	NOUN
ct-9922	11	24	because	because	SCONJ
ct-9922	11	25	the	the	DET
ct-9922	11	26	exogenous	exogenous	ADJ
ct-9922	11	27	dna	dna	NOUN
ct-9922	11	28	integrates	integrate	NOUN
ct-9922	11	29	to	to	ADP
ct-9922	11	30	a	a	DET
ct-9922	11	31	random	random	ADJ
ct-9922	11	32	location	location	NOUN
ct-9922	11	33	of	of	ADP
ct-9922	11	34	genome11	genome11	PROPN
ct-9922	11	35	therefore	therefore	ADV
ct-9922	11	36	,	,	PUNCT
ct-9922	11	37	no	no	DET
ct-9922	11	38	targeted	target	VERB
ct-9922	11	39	disruption	disruption	NOUN
ct-9922	11	40	is	be	AUX
ct-9922	11	41	possible	possible	ADJ
ct-9922	11	42	and	and	CCONJ
ct-9922	11	43	the	the	DET
ct-9922	11	44	copy	copy	NOUN
ct-9922	11	45	number	number	NOUN
ct-9922	11	46	of	of	ADP
ct-9922	11	47	integrated	integrate	VERB
ct-9922	11	48	exogenous	exogenous	ADJ
ct-9922	11	49	dna	dna	NOUN
ct-9922	11	50	can	can	AUX
ct-9922	11	51	not	not	PART
ct-9922	11	52	be	be	AUX
ct-9922	11	53	controlled	control	VERB
ct-9922	11	54	.	.	PUNCT
ct-9922	12	1	in	in	ADP
ct-9922	12	2	mice	mouse	NOUN
ct-9922	12	3	,	,	PUNCT
ct-9922	12	4	use	use	NOUN
ct-9922	12	5	of	of	ADP
ct-9922	12	6	embryonic	embryonic	ADJ
ct-9922	12	7	stem	stem	NOUN
ct-9922	12	8	(	(	PUNCT
ct-9922	12	9	es	es	NOUN
ct-9922	12	10	)	)	PUNCT
ct-9922	12	11	cell	cell	NOUN
ct-9922	12	12	based	base	VERB
ct-9922	12	13	genetic	genetic	ADJ
ct-9922	12	14	engineering	engineering	NOUN
ct-9922	12	15	allow	allow	VERB
ct-9922	12	16	us	we	PRON
ct-9922	12	17	to	to	PART
ct-9922	12	18	overcome	overcome	VERB
ct-9922	12	19	these	these	DET
ct-9922	12	20	issues	issue	NOUN
ct-9922	12	21	.	.	PUNCT
ct-9922	13	1	homologous	homologous	ADJ
ct-9922	13	2	recombination	recombination	NOUN
ct-9922	13	3	-	-	PUNCT
ct-9922	13	4	based	base	VERB
ct-9922	13	5	gene	gene	NOUN
ct-9922	13	6	targeting	target	VERB
ct-9922	13	7	approach	approach	NOUN
ct-9922	13	8	permits	permit	VERB
ct-9922	13	9	us	we	PRON
ct-9922	13	10	to	to	PART
ct-9922	13	11	modify	modify	VERB
ct-9922	13	12	genome	genome	NOUN
ct-9922	13	13	in	in	ADP
ct-9922	13	14	es	es	NOUN
ct-9922	13	15	cells	cell	NOUN
ct-9922	13	16	,	,	PUNCT
ct-9922	13	17	then	then	ADV
ct-9922	13	18	es	es	VERB
ct-9922	13	19	cells	cell	NOUN
ct-9922	13	20	can	can	AUX
ct-9922	13	21	be	be	AUX
ct-9922	13	22	used	use	VERB
ct-9922	13	23	to	to	PART
ct-9922	13	24	generate	generate	VERB
ct-9922	13	25	a	a	DET
ct-9922	13	26	chimeric	chimeric	ADJ
ct-9922	13	27	mouse	mouse	NOUN
ct-9922	13	28	carrying	carry	VERB
ct-9922	13	29	the	the	DET
ct-9922	13	30	genetic	genetic	ADJ
ct-9922	13	31	modifications.12	modifications.12	NOUN
ct-9922	13	32	breeding	breed	VERB
ct-9922	13	33	the	the	DET
ct-9922	13	34	chimeric	chimeric	ADJ
ct-9922	13	35	mice	mouse	NOUN
ct-9922	13	36	establishes	establish	VERB
ct-9922	13	37	genetically	genetically	ADV
ct-9922	13	38	engineered	engineer	VERB
ct-9922	13	39	mouse	mouse	NOUN
ct-9922	13	40	models	model	NOUN
ct-9922	13	41	carrying	carry	VERB
ct-9922	13	42	desired	desire	VERB
ct-9922	13	43	genetic	genetic	ADJ
ct-9922	13	44	modifications	modification	NOUN
ct-9922	13	45	.	.	PUNCT
ct-9922	14	1	this	this	DET
ct-9922	14	2	technique	technique	NOUN
ct-9922	14	3	has	have	AUX
ct-9922	14	4	been	be	AUX
ct-9922	14	5	the	the	DET
ct-9922	14	6	main	main	ADJ
ct-9922	14	7	approach	approach	NOUN
ct-9922	14	8	to	to	PART
ct-9922	14	9	generate	generate	VERB
ct-9922	14	10	knockout	knockout	NOUN
ct-9922	14	11	mouse	mouse	NOUN
ct-9922	14	12	models	model	NOUN
ct-9922	14	13	,	,	PUNCT
ct-9922	14	14	which	which	PRON
ct-9922	14	15	are	be	AUX
ct-9922	14	16	valuable	valuable	ADJ
ct-9922	14	17	animal	animal	NOUN
ct-9922	14	18	models	model	NOUN
ct-9922	14	19	in	in	ADP
ct-9922	14	20	biological	biological	ADJ
ct-9922	14	21	sciences.13	sciences.13	NOUN
ct-9922	14	22	-	-	SYM
ct-9922	14	23	15	15	NUM
ct-9922	14	24	however	however	ADV
ct-9922	14	25	,	,	PUNCT
ct-9922	14	26	the	the	DET
ct-9922	14	27	lack	lack	NOUN
ct-9922	14	28	of	of	ADP
ct-9922	14	29	true	true	ADJ
ct-9922	14	30	es	es	NOUN
ct-9922	14	31	cells	cell	NOUN
ct-9922	14	32	in	in	ADP
ct-9922	14	33	livestock	livestock	NOUN
ct-9922	14	34	has	have	AUX
ct-9922	14	35	prohibited	prohibit	VERB
ct-9922	14	36	this	this	DET
ct-9922	14	37	approach	approach	NOUN
ct-9922	14	38	in	in	ADP
ct-9922	14	39	producing	produce	VERB
ct-9922	14	40	genetically	genetically	ADV
ct-9922	14	41	engineered	engineer	VERB
ct-9922	14	42	livestock	livestock	NOUN
ct-9922	14	43	.	.	PUNCT
ct-9922	15	1	alternatively	alternatively	ADV
ct-9922	15	2	,	,	PUNCT
ct-9922	15	3	application	application	NOUN
ct-9922	15	4	of	of	ADP
ct-9922	15	5	somatic	somatic	ADJ
ct-9922	15	6	cell	cell	NOUN
ct-9922	15	7	nuclear	nuclear	ADJ
ct-9922	15	8	transfer	transfer	NOUN
ct-9922	15	9	(	(	PUNCT
ct-9922	15	10	scnt	scnt	ADJ
ct-9922	15	11	)	)	PUNCT
ct-9922	15	12	,	,	PUNCT
ct-9922	15	13	i.e.	i.e.	X
ct-9922	15	14	cloning	cloning	NOUN
ct-9922	15	15	,	,	PUNCT
ct-9922	15	16	allows	allow	VERB
ct-9922	15	17	us	we	PRON
ct-9922	15	18	to	to	PART
ct-9922	15	19	bypass	bypass	VERB
ct-9922	15	20	the	the	DET
ct-9922	15	21	need	need	NOUN
ct-9922	15	22	of	of	ADP
ct-9922	15	23	es	es	NOUN
ct-9922	15	24	cells	cell	NOUN
ct-9922	15	25	in	in	ADP
ct-9922	15	26	production	production	NOUN
ct-9922	15	27	of	of	ADP
ct-9922	15	28	genetically	genetically	ADV
ct-9922	15	29	engineered	engineer	VERB
ct-9922	15	30	livestock	livestock	NOUN
ct-9922	15	31	.	.	PUNCT
ct-9922	16	1	early	early	ADJ
ct-9922	16	2	experiments	experiment	NOUN
ct-9922	16	3	used	use	VERB
ct-9922	16	4	embryonic	embryonic	ADJ
ct-9922	16	5	cells	cell	NOUN
ct-9922	16	6	from	from	ADP
ct-9922	16	7	cleavage	cleavage	NOUN
ct-9922	16	8	stage	stage	NOUN
ct-9922	16	9	embryos	embryo	NOUN
ct-9922	16	10	or	or	CCONJ
ct-9922	16	11	blastocysts	blastocyst	NOUN
ct-9922	16	12	as	as	ADP
ct-9922	16	13	donor	donor	NOUN
ct-9922	16	14	nuclei	nucleus	NOUN
ct-9922	16	15	:	:	PUNCT
ct-9922	16	16	cattle16,17	cattle16,17	NOUN
ct-9922	16	17	and	and	CCONJ
ct-9922	16	18	pigs.18	pigs.18	NOUN
ct-9922	16	19	later	later	ADV
ct-9922	16	20	,	,	PUNCT
ct-9922	16	21	it	it	PRON
ct-9922	16	22	was	be	AUX
ct-9922	16	23	demonstrated	demonstrate	VERB
ct-9922	16	24	that	that	SCONJ
ct-9922	16	25	somatic	somatic	ADJ
ct-9922	16	26	cells	cell	NOUN
ct-9922	16	27	,	,	PUNCT
ct-9922	16	28	such	such	ADJ
ct-9922	16	29	as	as	ADP
ct-9922	16	30	fetal	fetal	ADJ
ct-9922	16	31	derived	derive	VERB
ct-9922	16	32	fibroblasts19	fibroblasts19	NOUN
ct-9922	16	33	or	or	CCONJ
ct-9922	16	34	adult	adult	NOUN
ct-9922	16	35	derived	derive	VERB
ct-9922	16	36	cells,20	cells,20	NOUN
ct-9922	16	37	could	could	AUX
ct-9922	16	38	have	have	VERB
ct-9922	16	39	full	full	ADJ
ct-9922	16	40	term	term	NOUN
ct-9922	16	41	development	development	NOUN
ct-9922	16	42	through	through	ADP
ct-9922	16	43	scnt	scnt	PRON
ct-9922	16	44	when	when	SCONJ
ct-9922	16	45	used	use	VERB
ct-9922	16	46	as	as	ADP
ct-9922	16	47	donor	donor	NOUN
ct-9922	16	48	cells	cell	NOUN
ct-9922	16	49	.	.	PUNCT
ct-9922	17	1	this	this	PRON
ct-9922	17	2	was	be	AUX
ct-9922	17	3	a	a	DET
ct-9922	17	4	groundbreaking	groundbreake	VERB
ct-9922	17	5	report	report	NOUN
ct-9922	17	6	in	in	ADP
ct-9922	17	7	cellular	cellular	ADJ
ct-9922	17	8	reprogramming	reprogramming	NOUN
ct-9922	17	9	,	,	PUNCT
ct-9922	17	10	but	but	CCONJ
ct-9922	17	11	also	also	ADV
ct-9922	17	12	indicated	indicate	VERB
ct-9922	17	13	that	that	SCONJ
ct-9922	17	14	genetic	genetic	ADJ
ct-9922	17	15	engineering	engineering	NOUN
ct-9922	17	16	of	of	ADP
ct-9922	17	17	donor	donor	NOUN
ct-9922	17	18	cells	cell	NOUN
ct-9922	17	19	followed	follow	VERB
ct-9922	17	20	by	by	ADP
ct-9922	17	21	scnt	scnt	NOUN
ct-9922	17	22	could	could	AUX
ct-9922	17	23	be	be	AUX
ct-9922	17	24	an	an	DET
ct-9922	17	25	ideal	ideal	ADJ
ct-9922	17	26	system	system	NOUN
ct-9922	17	27	to	to	PART
ct-9922	17	28	produce	produce	VERB
ct-9922	17	29	genetically	genetically	ADV
ct-9922	17	30	engineered	engineer	VERB
ct-9922	17	31	livestock	livestock	NOUN
ct-9922	17	32	.	.	PUNCT
ct-9922	18	1	the	the	DET
ct-9922	18	2	strategy	strategy	NOUN
ct-9922	18	3	was	be	AUX
ct-9922	18	4	quickly	quickly	ADV
ct-9922	18	5	adopted	adopt	VERB
ct-9922	18	6	and	and	CCONJ
ct-9922	18	7	resulted	result	VERB
ct-9922	18	8	in	in	ADP
ct-9922	18	9	the	the	DET
ct-9922	18	10	production	production	NOUN
ct-9922	18	11	of	of	ADP
ct-9922	18	12	genetically	genetically	ADV
ct-9922	18	13	engineered	engineer	VERB
ct-9922	18	14	livestock21	livestock21	NOUN
ct-9922	18	15	-	-	PUNCT
ct-9922	18	16	24	24	NUM
ct-9922	18	17	for	for	ADP
ct-9922	18	18	various	various	ADJ
ct-9922	18	19	applications	application	NOUN
ct-9922	18	20	.	.	PUNCT
ct-9922	19	1	however	however	ADV
ct-9922	19	2	,	,	PUNCT
ct-9922	19	3	efficiency	efficiency	NOUN
ct-9922	19	4	of	of	ADP
ct-9922	19	5	gene	gene	NOUN
ct-9922	19	6	targeting	target	VERB
ct-9922	19	7	through	through	ADP
ct-9922	19	8	conventional	conventional	ADJ
ct-9922	19	9	hr	hr	NOUN
ct-9922	19	10	is	be	AUX
ct-9922	19	11	extremely	extremely	ADV
ct-9922	19	12	poor	poor	ADJ
ct-9922	19	13	thus	thus	ADV
ct-9922	19	14	only	only	ADV
ct-9922	19	15	limited	limited	ADJ
ct-9922	19	16	reports	report	NOUN
ct-9922	19	17	of	of	ADP
ct-9922	19	18	genetically	genetically	ADV
ct-9922	19	19	engineered	engineer	VERB
ct-9922	19	20	livestock	livestock	NOUN
ct-9922	19	21	have	have	AUX
ct-9922	19	22	been	be	AUX
ct-9922	19	23	made	make	VERB
ct-9922	19	24	.	.	PUNCT
ct-9922	20	1	recent	recent	ADJ
ct-9922	20	2	developments	development	NOUN
ct-9922	20	3	in	in	ADP
ct-9922	20	4	gene	gene	NOUN
ct-9922	20	5	-	-	PUNCT
ct-9922	20	6	editing	edit	VERB
ct-9922	20	7	technology	technology	NOUN
ct-9922	20	8	allow	allow	VERB
ct-9922	20	9	us	we	PRON
ct-9922	20	10	to	to	PART
ct-9922	20	11	introduce	introduce	VERB
ct-9922	20	12	site	site	NOUN
ct-9922	20	13	-	-	PUNCT
ct-9922	20	14	specific	specific	ADJ
ct-9922	20	15	genetic	genetic	ADJ
ct-9922	20	16	modifications	modification	NOUN
ct-9922	20	17	in	in	ADP
ct-9922	20	18	somatic	somatic	ADJ
ct-9922	20	19	cells	cell	NOUN
ct-9922	20	20	at	at	ADP
ct-9922	20	21	high	high	ADJ
ct-9922	20	22	efficiency	efficiency	NOUN
ct-9922	20	23	.	.	PUNCT
ct-9922	21	1	specifically	specifically	ADV
ct-9922	21	2	,	,	PUNCT
ct-9922	21	3	the	the	DET
ct-9922	21	4	use	use	NOUN
ct-9922	21	5	of	of	ADP
ct-9922	21	6	engineered	engineer	VERB
ct-9922	21	7	endonucleases	endonuclease	NOUN
ct-9922	21	8	such	such	ADJ
ct-9922	21	9	as	as	ADP
ct-9922	21	10	zinc	zinc	NOUN
ct-9922	21	11	-	-	PUNCT
ct-9922	21	12	finger	finger	NOUN
ct-9922	21	13	nucleases	nuclease	NOUN
ct-9922	21	14	(	(	PUNCT
ct-9922	21	15	zfns	zfns	NOUN
ct-9922	21	16	)	)	PUNCT
ct-9922	21	17	,	,	PUNCT
ct-9922	21	18	transcription	transcription	NOUN
ct-9922	21	19	activator	activator	NOUN
ct-9922	21	20	-	-	PUNCT
ct-9922	21	21	like	like	ADJ
ct-9922	21	22	effector	effector	NOUN
ct-9922	21	23	nucleases	nuclease	NOUN
ct-9922	21	24	(	(	PUNCT
ct-9922	21	25	talens	talen	NOUN
ct-9922	21	26	)	)	PUNCT
ct-9922	21	27	,	,	PUNCT
ct-9922	21	28	and	and	CCONJ
ct-9922	21	29	clustered	cluster	VERB
ct-9922	21	30	regularly	regularly	ADV
ct-9922	21	31	interspaced	interspace	VERB
ct-9922	21	32	short	short	ADJ
ct-9922	21	33	palindromic	palindromic	ADJ
ct-9922	21	34	repeat	repeat	NOUN
ct-9922	21	35	(	(	PUNCT
ct-9922	21	36	crispr)/crispr	crispr)/crispr	ADV
ct-9922	21	37	-	-	PUNCT
ct-9922	21	38	associated	associate	VERB
ct-9922	21	39	9	9	NUM
ct-9922	21	40	(	(	PUNCT
ct-9922	21	41	cas9	cas9	NOUN
ct-9922	21	42	)	)	PUNCT
ct-9922	21	43	system	system	NOUN
ct-9922	21	44	can	can	AUX
ct-9922	21	45	introduce	introduce	VERB
ct-9922	21	46	homozygous	homozygous	ADJ
ct-9922	21	47	or	or	CCONJ
ct-9922	21	48	biallelic	biallelic	ADJ
ct-9922	21	49	clinical	clinical	ADJ
ct-9922	21	50	theriogenology	theriogenology	NOUN
ct-9922	21	51	•	•	NOUN
ct-9922	21	52	volume	volume	NOUN
ct-9922	21	53	10	10	NUM
ct-9922	21	54	,	,	PUNCT
ct-9922	21	55	number	number	NOUN
ct-9922	21	56	3	3	NUM
ct-9922	21	57	•	•	NOUN
ct-9922	21	58	september	september	PROPN
ct-9922	21	59	2018239	2018239	NUM
ct-9922	21	60	modifications	modification	NOUN
ct-9922	21	61	in	in	ADP
ct-9922	21	62	somatic	somatic	ADJ
ct-9922	21	63	cells	cell	NOUN
ct-9922	21	64	in	in	ADP
ct-9922	21	65	various	various	ADJ
ct-9922	21	66	livestock	livestock	NOUN
ct-9922	21	67	species.25	species.25	PROPN
ct-9922	21	68	-	-	PUNCT
ct-9922	21	69	27	27	NUM
ct-9922	21	70	in	in	ADP
ct-9922	21	71	addition	addition	NOUN
ct-9922	21	72	,	,	PUNCT
ct-9922	21	73	the	the	DET
ct-9922	21	74	systems	system	NOUN
ct-9922	21	75	are	be	AUX
ct-9922	21	76	powerful	powerful	ADJ
ct-9922	21	77	enough	enough	ADV
ct-9922	21	78	to	to	PART
ct-9922	21	79	introduce	introduce	VERB
ct-9922	21	80	genetic	genetic	ADJ
ct-9922	21	81	modifications	modification	NOUN
ct-9922	21	82	during	during	ADP
ct-9922	21	83	embryogenesis	embryogenesis	NOUN
ct-9922	21	84	,	,	PUNCT
ct-9922	21	85	thus	thus	ADV
ct-9922	21	86	bypassing	bypass	VERB
ct-9922	21	87	the	the	DET
ct-9922	21	88	need	need	NOUN
ct-9922	21	89	of	of	ADP
ct-9922	21	90	scnt	scnt	PRON
ct-9922	21	91	in	in	ADP
ct-9922	21	92	generating	generate	VERB
ct-9922	21	93	genetically	genetically	ADV
ct-9922	21	94	engineered	engineer	VERB
ct-9922	21	95	livestock.28	livestock.28	NOUN
ct-9922	21	96	these	these	DET
ct-9922	21	97	gene	gene	NOUN
ct-9922	21	98	-	-	PUNCT
ct-9922	21	99	editing	edit	VERB
ct-9922	21	100	systems	system	NOUN
ct-9922	21	101	furnish	furnish	VERB
ct-9922	21	102	unprecedented	unprecedented	ADJ
ct-9922	21	103	opportunities	opportunity	NOUN
ct-9922	21	104	to	to	PART
ct-9922	21	105	enhance	enhance	VERB
ct-9922	21	106	the	the	DET
ct-9922	21	107	genetic	genetic	ADJ
ct-9922	21	108	value	value	NOUN
ct-9922	21	109	of	of	ADP
ct-9922	21	110	livestock	livestock	NOUN
ct-9922	21	111	species	specie	NOUN
ct-9922	21	112	.	.	PUNCT
ct-9922	22	1	mechanistic	mechanistic	ADJ
ct-9922	22	2	action	action	NOUN
ct-9922	22	3	of	of	ADP
ct-9922	22	4	gene	gene	NOUN
ct-9922	22	5	-	-	PUNCT
ct-9922	22	6	editing	edit	VERB
ct-9922	22	7	system	system	NOUN
ct-9922	22	8	:	:	PUNCT
ct-9922	22	9	engineered	engineer	VERB
ct-9922	22	10	endonucleases	endonuclease	NOUN
ct-9922	22	11	the	the	DET
ct-9922	22	12	gene	gene	NOUN
ct-9922	22	13	-	-	PUNCT
ct-9922	22	14	editing	edit	VERB
ct-9922	22	15	systems	system	NOUN
ct-9922	22	16	are	be	AUX
ct-9922	22	17	labeled	label	VERB
ct-9922	22	18	as	as	ADP
ct-9922	22	19	engineered	engineer	VERB
ct-9922	22	20	endonucleases	endonuclease	NOUN
ct-9922	22	21	because	because	SCONJ
ct-9922	22	22	they	they	PRON
ct-9922	22	23	can	can	AUX
ct-9922	22	24	bind	bind	VERB
ct-9922	22	25	to	to	ADP
ct-9922	22	26	a	a	DET
ct-9922	22	27	specific	specific	ADJ
ct-9922	22	28	region	region	NOUN
ct-9922	22	29	of	of	ADP
ct-9922	22	30	genome	genome	NOUN
ct-9922	22	31	and	and	CCONJ
ct-9922	22	32	induce	induce	VERB
ct-9922	22	33	a	a	DET
ct-9922	22	34	double	double	ADJ
ct-9922	22	35	-	-	PUNCT
ct-9922	22	36	strand	strand	NOUN
ct-9922	22	37	break	break	NOUN
ct-9922	22	38	(	(	PUNCT
ct-9922	22	39	dsb	dsb	PROPN
ct-9922	22	40	)	)	PUNCT
ct-9922	22	41	in	in	ADP
ct-9922	22	42	the	the	DET
ct-9922	22	43	chromosome	chromosome	NOUN
ct-9922	22	44	,	,	PUNCT
ct-9922	22	45	allowing	allow	VERB
ct-9922	22	46	introduction	introduction	NOUN
ct-9922	22	47	of	of	ADP
ct-9922	22	48	targeted	target	VERB
ct-9922	22	49	modification	modification	NOUN
ct-9922	22	50	into	into	ADP
ct-9922	22	51	the	the	DET
ct-9922	22	52	locus	locus	NOUN
ct-9922	22	53	(	(	PUNCT
ct-9922	22	54	reviewed	review	VERB
ct-9922	22	55	in2,29	in2,29	NOUN
ct-9922	22	56	)	)	PUNCT
ct-9922	22	57	.	.	PUNCT
ct-9922	23	1	endogenous	endogenous	ADJ
ct-9922	23	2	dna	dna	PROPN
ct-9922	23	3	repair	repair	NOUN
ct-9922	23	4	pathways	pathway	NOUN
ct-9922	23	5	,	,	PUNCT
ct-9922	23	6	non	non	ADJ
ct-9922	23	7	-	-	ADJ
ct-9922	23	8	homologous	homologous	ADJ
ct-9922	23	9	end	end	NOUN
ct-9922	23	10	joining	join	VERB
ct-9922	23	11	(	(	PUNCT
ct-9922	23	12	nhej	nhej	ADJ
ct-9922	23	13	)	)	PUNCT
ct-9922	23	14	or	or	CCONJ
ct-9922	23	15	homologous	homologous	ADJ
ct-9922	23	16	recombination	recombination	NOUN
ct-9922	23	17	(	(	PUNCT
ct-9922	23	18	hr	hr	NOUN
ct-9922	23	19	)	)	PUNCT
ct-9922	23	20	,	,	PUNCT
ct-9922	23	21	are	be	AUX
ct-9922	23	22	vigorously	vigorously	ADV
ct-9922	23	23	activated	activate	VERB
ct-9922	23	24	by	by	ADP
ct-9922	23	25	response	response	NOUN
ct-9922	23	26	to	to	ADP
ct-9922	23	27	the	the	DET
ct-9922	23	28	dsb	dsb	NOUN
ct-9922	23	29	.	.	PUNCT
ct-9922	24	1	the	the	DET
ct-9922	24	2	repair	repair	NOUN
ct-9922	24	3	through	through	ADP
ct-9922	24	4	nhej	nhej	ADJ
ct-9922	24	5	does	do	AUX
ct-9922	24	6	not	not	PART
ct-9922	24	7	rely	rely	VERB
ct-9922	24	8	on	on	ADP
ct-9922	24	9	template	template	NOUN
ct-9922	24	10	dna	dna	NOUN
ct-9922	24	11	,	,	PUNCT
ct-9922	24	12	thus	thus	ADV
ct-9922	24	13	it	it	PRON
ct-9922	24	14	may	may	AUX
ct-9922	24	15	result	result	VERB
ct-9922	24	16	in	in	ADP
ct-9922	24	17	the	the	DET
ct-9922	24	18	formation	formation	NOUN
ct-9922	24	19	of	of	ADP
ct-9922	24	20	small	small	ADJ
ct-9922	24	21	insertion	insertion	NOUN
ct-9922	24	22	or	or	CCONJ
ct-9922	24	23	deletion	deletion	NOUN
ct-9922	24	24	(	(	PUNCT
ct-9922	24	25	indels	indel	NOUN
ct-9922	24	26	)	)	PUNCT
ct-9922	24	27	.	.	PUNCT
ct-9922	25	1	these	these	DET
ct-9922	25	2	small	small	ADJ
ct-9922	25	3	indels	indel	NOUN
ct-9922	25	4	often	often	ADV
ct-9922	25	5	cause	cause	VERB
ct-9922	25	6	frameshifts	frameshift	NOUN
ct-9922	25	7	on	on	ADP
ct-9922	25	8	the	the	DET
ct-9922	25	9	coding	code	VERB
ct-9922	25	10	region	region	NOUN
ct-9922	25	11	of	of	ADP
ct-9922	25	12	the	the	DET
ct-9922	25	13	target	target	NOUN
ct-9922	25	14	gene	gene	NOUN
ct-9922	25	15	,	,	PUNCT
ct-9922	25	16	resulting	result	VERB
ct-9922	25	17	in	in	ADP
ct-9922	25	18	a	a	DET
ct-9922	25	19	targeted	target	VERB
ct-9922	25	20	disruption	disruption	NOUN
ct-9922	25	21	.	.	PUNCT
ct-9922	26	1	the	the	DET
ct-9922	26	2	repair	repair	NOUN
ct-9922	26	3	through	through	ADP
ct-9922	26	4	hr	hr	NOUN
ct-9922	26	5	is	be	AUX
ct-9922	26	6	accurate	accurate	ADJ
ct-9922	26	7	at	at	ADP
ct-9922	26	8	the	the	DET
ct-9922	26	9	nucleotide	nucleotide	ADJ
ct-9922	26	10	level	level	NOUN
ct-9922	26	11	,	,	PUNCT
ct-9922	26	12	as	as	SCONJ
ct-9922	26	13	it	it	PRON
ct-9922	26	14	utilizes	utilize	VERB
ct-9922	26	15	the	the	DET
ct-9922	26	16	dna	dna	PROPN
ct-9922	26	17	template	template	NOUN
ct-9922	26	18	,	,	PUNCT
ct-9922	26	19	in	in	ADP
ct-9922	26	20	nature	nature	NOUN
ct-9922	26	21	sister	sister	NOUN
ct-9922	26	22	chromatid	chromatid	ADJ
ct-9922	26	23	,	,	PUNCT
ct-9922	26	24	to	to	PART
ct-9922	26	25	correct	correct	VERB
ct-9922	26	26	damages	damage	NOUN
ct-9922	26	27	caused	cause	VERB
ct-9922	26	28	by	by	ADP
ct-9922	26	29	the	the	DET
ct-9922	26	30	dsb	dsb	NOUN
ct-9922	26	31	.	.	PUNCT
ct-9922	27	1	introducing	introduce	VERB
ct-9922	27	2	donor	donor	NOUN
ct-9922	27	3	dna	dna	NOUN
ct-9922	27	4	with	with	ADP
ct-9922	27	5	engineered	engineer	VERB
ct-9922	27	6	endonucleases	endonuclease	NOUN
ct-9922	27	7	can	can	AUX
ct-9922	27	8	induce	induce	VERB
ct-9922	27	9	targeted	targeted	ADJ
ct-9922	27	10	insertion	insertion	NOUN
ct-9922	27	11	of	of	ADP
ct-9922	27	12	specific	specific	ADJ
ct-9922	27	13	dna	dna	PROPN
ct-9922	27	14	sequences	sequence	NOUN
ct-9922	27	15	or	or	CCONJ
ct-9922	27	16	exogenous	exogenous	ADJ
ct-9922	27	17	genes	gene	NOUN
ct-9922	27	18	into	into	ADP
ct-9922	27	19	the	the	DET
ct-9922	27	20	dsb	dsb	NOUN
ct-9922	27	21	locus	locu	VERB
ct-9922	27	22	through	through	ADP
ct-9922	27	23	homology	homology	NOUN
ct-9922	27	24	-	-	PUNCT
ct-9922	27	25	directed	direct	VERB
ct-9922	27	26	repair	repair	NOUN
ct-9922	27	27	(	(	PUNCT
ct-9922	27	28	hdr	hdr	NOUN
ct-9922	27	29	)	)	PUNCT
ct-9922	27	30	pathway	pathway	NOUN
ct-9922	27	31	.	.	PUNCT
ct-9922	28	1	the	the	DET
ct-9922	28	2	modifications	modification	NOUN
ct-9922	28	3	through	through	ADP
ct-9922	28	4	hdr	hdr	NOUN
ct-9922	28	5	is	be	AUX
ct-9922	28	6	specific	specific	ADJ
ct-9922	28	7	at	at	ADP
ct-9922	28	8	the	the	DET
ct-9922	28	9	nucleotide	nucleotide	ADJ
ct-9922	28	10	level	level	NOUN
ct-9922	28	11	.	.	PUNCT
ct-9922	29	1	genetically	genetically	ADV
ct-9922	29	2	engineered	engineer	VERB
ct-9922	29	3	livestock	livestock	NOUN
ct-9922	29	4	by	by	ADP
ct-9922	29	5	zfns	zfns	PROPN
ct-9922	29	6	zinc	zinc	NOUN
ct-9922	29	7	-	-	PUNCT
ct-9922	29	8	finger	finger	NOUN
ct-9922	29	9	nucleases	nuclease	NOUN
ct-9922	29	10	(	(	PUNCT
ct-9922	29	11	zfns	zfns	NOUN
ct-9922	29	12	)	)	PUNCT
ct-9922	29	13	were	be	AUX
ct-9922	29	14	the	the	DET
ct-9922	29	15	first	first	ADJ
ct-9922	29	16	developed	develop	VERB
ct-9922	29	17	engineered	engineer	VERB
ct-9922	29	18	endonucleases	endonuclease	NOUN
ct-9922	29	19	,	,	PUNCT
ct-9922	29	20	consisting	consist	VERB
ct-9922	29	21	of	of	ADP
ct-9922	29	22	zinc	zinc	NOUN
ct-9922	29	23	-	-	PUNCT
ct-9922	29	24	finger	finger	NOUN
ct-9922	29	25	proteins	protein	NOUN
ct-9922	29	26	,	,	PUNCT
ct-9922	29	27	which	which	PRON
ct-9922	29	28	recognize	recognize	VERB
ct-9922	29	29	specific	specific	ADJ
ct-9922	29	30	dna	dna	NOUN
ct-9922	29	31	sequences	sequence	NOUN
ct-9922	29	32	,	,	PUNCT
ct-9922	29	33	and	and	CCONJ
ct-9922	29	34	foki	foki	ADJ
ct-9922	29	35	enzyme	enzyme	NOUN
ct-9922	29	36	,	,	PUNCT
ct-9922	29	37	a	a	DET
ct-9922	29	38	non	non	ADJ
ct-9922	29	39	-	-	ADJ
ct-9922	29	40	specific	specific	ADJ
ct-9922	29	41	endonuclease	endonuclease	NOUN
ct-9922	29	42	.	.	PUNCT
ct-9922	30	1	each	each	DET
ct-9922	30	2	zinc	zinc	NOUN
ct-9922	30	3	-	-	PUNCT
ct-9922	30	4	finger	finger	NOUN
ct-9922	30	5	protein	protein	NOUN
ct-9922	30	6	motif	motif	NOUN
ct-9922	30	7	,	,	PUNCT
ct-9922	30	8	originally	originally	ADV
ct-9922	30	9	identified	identify	VERB
ct-9922	30	10	from	from	ADP
ct-9922	30	11	xenopus	xenopus	PROPN
ct-9922	30	12	oocytes,30	oocytes,30	PROPN
ct-9922	30	13	can	can	AUX
ct-9922	30	14	recognize	recognize	VERB
ct-9922	30	15	and	and	CCONJ
ct-9922	30	16	bind	bind	VERB
ct-9922	30	17	to	to	ADP
ct-9922	30	18	three	three	NUM
ct-9922	30	19	nucleotides	nucleotide	NOUN
ct-9922	30	20	.	.	PUNCT
ct-9922	31	1	the	the	DET
ct-9922	31	2	zinc	zinc	NOUN
ct-9922	31	3	-	-	PUNCT
ct-9922	31	4	finger	finger	NOUN
ct-9922	31	5	proteins	protein	NOUN
ct-9922	31	6	can	can	AUX
ct-9922	31	7	be	be	AUX
ct-9922	31	8	engineered	engineer	VERB
ct-9922	31	9	to	to	PART
ct-9922	31	10	recognize	recognize	VERB
ct-9922	31	11	any	any	DET
ct-9922	31	12	three	three	NUM
ct-9922	31	13	nucleotides	nucleotide	NOUN
ct-9922	31	14	in	in	ADP
ct-9922	31	15	the	the	DET
ct-9922	31	16	genome	genome	NOUN
ct-9922	31	17	,	,	PUNCT
ct-9922	31	18	and	and	CCONJ
ct-9922	31	19	these	these	DET
ct-9922	31	20	proteins	protein	NOUN
ct-9922	31	21	can	can	AUX
ct-9922	31	22	be	be	AUX
ct-9922	31	23	connected	connect	VERB
ct-9922	31	24	to	to	PART
ct-9922	31	25	recognize	recognize	VERB
ct-9922	31	26	a	a	DET
ct-9922	31	27	longer	long	ADJ
ct-9922	31	28	dna	dna	NOUN
ct-9922	31	29	sequence	sequence	NOUN
ct-9922	31	30	.	.	PUNCT
ct-9922	32	1	these	these	DET
ct-9922	32	2	zinc	zinc	NOUN
ct-9922	32	3	-	-	PUNCT
ct-9922	32	4	finger	finger	NOUN
ct-9922	32	5	proteins	protein	NOUN
ct-9922	32	6	are	be	AUX
ct-9922	32	7	fused	fuse	VERB
ct-9922	32	8	with	with	ADP
ct-9922	32	9	a	a	DET
ct-9922	32	10	restriction	restriction	NOUN
ct-9922	32	11	endonuclease	endonuclease	NOUN
ct-9922	32	12	foki	foki	NOUN
ct-9922	32	13	to	to	PART
ct-9922	32	14	induce	induce	VERB
ct-9922	32	15	a	a	DET
ct-9922	32	16	site	site	NOUN
ct-9922	32	17	-	-	PUNCT
ct-9922	32	18	specific	specific	ADJ
ct-9922	32	19	dsb	dsb	NOUN
ct-9922	32	20	in	in	ADP
ct-9922	32	21	the	the	DET
ct-9922	32	22	genome	genome	NOUN
ct-9922	32	23	.	.	PUNCT
ct-9922	33	1	the	the	DET
ct-9922	33	2	use	use	NOUN
ct-9922	33	3	of	of	ADP
ct-9922	33	4	zfns	zfns	PROPN
ct-9922	33	5	dramatically	dramatically	ADV
ct-9922	33	6	improved	improve	VERB
ct-9922	33	7	the	the	DET
ct-9922	33	8	efficiency	efficiency	NOUN
ct-9922	33	9	of	of	ADP
ct-9922	33	10	gene	gene	NOUN
ct-9922	33	11	targeting	target	VERB
ct-9922	33	12	.	.	PUNCT
ct-9922	34	1	the	the	DET
ct-9922	34	2	first	first	ADJ
ct-9922	34	3	publication	publication	NOUN
ct-9922	34	4	using	use	VERB
ct-9922	34	5	human	human	ADJ
ct-9922	34	6	cells	cell	NOUN
ct-9922	34	7	demonstrated	demonstrate	VERB
ct-9922	34	8	that	that	SCONJ
ct-9922	34	9	the	the	DET
ct-9922	34	10	system	system	NOUN
ct-9922	34	11	can	can	AUX
ct-9922	34	12	induce	induce	VERB
ct-9922	34	13	targeted	targeted	ADJ
ct-9922	34	14	modifications	modification	NOUN
ct-9922	34	15	at	at	ADP
ct-9922	34	16	1,000fold	1,000fold	NUM
ct-9922	34	17	higher	high	ADJ
ct-9922	34	18	,	,	PUNCT
ct-9922	34	19	compared	compare	VERB
ct-9922	34	20	to	to	ADP
ct-9922	34	21	the	the	DET
ct-9922	34	22	conventional	conventional	ADJ
ct-9922	34	23	gene	gene	NOUN
ct-9922	34	24	targeting	target	VERB
ct-9922	34	25	approach.31	approach.31	NOUN
ct-9922	34	26	the	the	DET
ct-9922	34	27	zfns	zfns	NOUN
ct-9922	34	28	were	be	AUX
ct-9922	34	29	first	first	ADV
ct-9922	34	30	applied	apply	VERB
ct-9922	34	31	in	in	ADP
ct-9922	34	32	livestock	livestock	NOUN
ct-9922	34	33	to	to	PART
ct-9922	34	34	generate	generate	VERB
ct-9922	34	35	biomedical	biomedical	ADJ
ct-9922	34	36	pig	pig	NOUN
ct-9922	34	37	models.32,33	models.32,33	NOUN
ct-9922	34	38	for	for	ADP
ct-9922	34	39	agricultural	agricultural	ADJ
ct-9922	34	40	application	application	NOUN
ct-9922	34	41	,	,	PUNCT
ct-9922	34	42	zfns	zfns	PROPN
ct-9922	34	43	were	be	AUX
ct-9922	34	44	first	first	ADV
ct-9922	34	45	used	use	VERB
ct-9922	34	46	to	to	PART
ct-9922	34	47	generate	generate	VERB
ct-9922	34	48	genetically	genetically	ADV
ct-9922	34	49	engineered	engineer	VERB
ct-9922	34	50	cattle	cattle	NOUN
ct-9922	34	51	with	with	ADP
ct-9922	34	52	a	a	DET
ct-9922	34	53	different	different	ADJ
ct-9922	34	54	milk	milk	NOUN
ct-9922	34	55	composition	composition	NOUN
ct-9922	34	56	.	.	PUNCT
ct-9922	35	1	genetically	genetically	ADV
ct-9922	35	2	engineered	engineer	VERB
ct-9922	35	3	cattle	cattle	NOUN
ct-9922	35	4	carrying	carry	VERB
ct-9922	35	5	modified	modify	VERB
ct-9922	35	6	beta	beta	NOUN
ct-9922	35	7	-	-	PUNCT
ct-9922	35	8	lactoglobulin	lactoglobulin	NOUN
ct-9922	35	9	(	(	PUNCT
ct-9922	35	10	blg	blg	PROPN
ct-9922	35	11	)	)	PUNCT
ct-9922	35	12	gene	gene	NOUN
ct-9922	35	13	,	,	PUNCT
ct-9922	35	14	known	know	VERB
ct-9922	35	15	as	as	ADP
ct-9922	35	16	one	one	NUM
ct-9922	35	17	of	of	ADP
ct-9922	35	18	the	the	DET
ct-9922	35	19	major	major	ADJ
ct-9922	35	20	milk	milk	NOUN
ct-9922	35	21	allergens	allergen	NOUN
ct-9922	35	22	,	,	PUNCT
ct-9922	35	23	was	be	AUX
ct-9922	35	24	produced	produce	VERB
ct-9922	35	25	by	by	ADP
ct-9922	35	26	utilizing	utilize	VERB
ct-9922	35	27	zfns.34	zfns.34	NOUN
ct-9922	35	28	in	in	ADP
ct-9922	35	29	this	this	DET
ct-9922	35	30	study	study	NOUN
ct-9922	35	31	,	,	PUNCT
ct-9922	35	32	first	first	ADJ
ct-9922	35	33	zfns	zfns	PROPN
ct-9922	35	34	were	be	AUX
ct-9922	35	35	used	use	VERB
ct-9922	35	36	to	to	PART
ct-9922	35	37	alter	alter	VERB
ct-9922	35	38	blg	blg	PROPN
ct-9922	35	39	gene	gene	PROPN
ct-9922	35	40	in	in	ADP
ct-9922	35	41	bovine	bovine	NOUN
ct-9922	35	42	cell	cell	NOUN
ct-9922	35	43	lines	line	NOUN
ct-9922	35	44	through	through	ADP
ct-9922	35	45	nhej	nhej	ADJ
ct-9922	35	46	repair	repair	NOUN
ct-9922	35	47	pathway	pathway	NOUN
ct-9922	35	48	.	.	PUNCT
ct-9922	36	1	then	then	ADV
ct-9922	36	2	,	,	PUNCT
ct-9922	36	3	two	two	NUM
ct-9922	36	4	cell	cell	NOUN
ct-9922	36	5	lines	line	NOUN
ct-9922	36	6	containing	contain	VERB
ct-9922	36	7	biallelic	biallelic	ADJ
ct-9922	36	8	mutation	mutation	NOUN
ct-9922	36	9	in	in	ADP
ct-9922	36	10	the	the	DET
ct-9922	36	11	blg	blg	PROPN
ct-9922	36	12	locus	locus	NOUN
ct-9922	36	13	were	be	AUX
ct-9922	36	14	used	use	VERB
ct-9922	36	15	as	as	ADP
ct-9922	36	16	nucleus	nucleus	ADJ
ct-9922	36	17	donors	donor	NOUN
ct-9922	36	18	for	for	ADP
ct-9922	36	19	scnt	scnt	ADV
ct-9922	36	20	.	.	PUNCT
ct-9922	37	1	a	a	DET
ct-9922	37	2	total	total	NOUN
ct-9922	37	3	of	of	ADP
ct-9922	37	4	eight	eight	NUM
ct-9922	37	5	live	live	ADJ
ct-9922	37	6	animals	animal	NOUN
ct-9922	37	7	were	be	AUX
ct-9922	37	8	born	bear	VERB
ct-9922	37	9	through	through	ADP
ct-9922	37	10	the	the	DET
ct-9922	37	11	scnt	scnt	NOUN
ct-9922	37	12	,	,	PUNCT
ct-9922	37	13	but	but	CCONJ
ct-9922	37	14	only	only	ADV
ct-9922	37	15	one	one	NUM
ct-9922	37	16	cow	cow	NOUN
ct-9922	37	17	survived	survive	VERB
ct-9922	37	18	over	over	ADP
ct-9922	37	19	a	a	DET
ct-9922	37	20	month	month	NOUN
ct-9922	37	21	.	.	PUNCT
ct-9922	38	1	the	the	DET
ct-9922	38	2	report	report	NOUN
ct-9922	38	3	did	do	AUX
ct-9922	38	4	not	not	PART
ct-9922	38	5	comment	comment	VERB
ct-9922	38	6	on	on	ADP
ct-9922	38	7	the	the	DET
ct-9922	38	8	quality	quality	NOUN
ct-9922	38	9	of	of	ADP
ct-9922	38	10	milk	milk	NOUN
ct-9922	38	11	from	from	ADP
ct-9922	38	12	the	the	DET
ct-9922	38	13	cow	cow	NOUN
ct-9922	38	14	,	,	PUNCT
ct-9922	38	15	probably	probably	ADV
ct-9922	38	16	due	due	ADJ
ct-9922	38	17	to	to	ADP
ct-9922	38	18	extended	extend	VERB
ct-9922	38	19	time	time	NOUN
ct-9922	38	20	required	require	VERB
ct-9922	38	21	to	to	PART
ct-9922	38	22	breed	breed	VERB
ct-9922	38	23	and	and	CCONJ
ct-9922	38	24	obtain	obtain	VERB
ct-9922	38	25	milk	milk	NOUN
ct-9922	38	26	from	from	ADP
ct-9922	38	27	the	the	DET
ct-9922	38	28	cow	cow	NOUN
ct-9922	38	29	.	.	PUNCT
ct-9922	39	1	another	another	DET
ct-9922	39	2	study	study	NOUN
ct-9922	39	3	applied	apply	VERB
ct-9922	39	4	zinc	zinc	NOUN
ct-9922	39	5	-	-	PUNCT
ct-9922	39	6	finger	finger	NOUN
ct-9922	39	7	nickases	nickase	NOUN
ct-9922	39	8	(	(	PUNCT
ct-9922	39	9	zfnickases	zfnickase	NOUN
ct-9922	39	10	)	)	PUNCT
ct-9922	39	11	to	to	PART
ct-9922	39	12	produce	produce	VERB
ct-9922	39	13	dairy	dairy	NOUN
ct-9922	39	14	cattle	cattle	NOUN
ct-9922	39	15	which	which	PRON
ct-9922	39	16	can	can	AUX
ct-9922	39	17	be	be	AUX
ct-9922	39	18	resistant	resistant	ADJ
ct-9922	39	19	to	to	ADP
ct-9922	39	20	staphylococcus	staphylococcus	NOUN
ct-9922	39	21	aureus	aureus	PROPN
ct-9922	39	22	(	(	PUNCT
ct-9922	39	23	s.	s.	PROPN
ct-9922	39	24	aureus)-induced	aureus)-induced	PROPN
ct-9922	39	25	mastitis	mastitis	PROPN
ct-9922	39	26	.	.	PUNCT
ct-9922	40	1	use	use	NOUN
ct-9922	40	2	of	of	ADP
ct-9922	40	3	zfnikase	zfnikase	NOUN
ct-9922	40	4	instead	instead	ADV
ct-9922	40	5	of	of	ADP
ct-9922	40	6	zfns	zfns	PROPN
ct-9922	40	7	allowed	allow	VERB
ct-9922	40	8	them	they	PRON
ct-9922	40	9	to	to	PART
ct-9922	40	10	utilize	utilize	VERB
ct-9922	40	11	hdr	hdr	NOUN
ct-9922	40	12	pathway	pathway	NOUN
ct-9922	40	13	instead	instead	ADV
ct-9922	40	14	of	of	ADP
ct-9922	40	15	nhej	nhej	ADJ
ct-9922	40	16	because	because	SCONJ
ct-9922	40	17	zfnikases	zfnikase	NOUN
ct-9922	40	18	trigger	trigger	NOUN
ct-9922	40	19	site	site	NOUN
ct-9922	40	20	-	-	PUNCT
ct-9922	40	21	specific	specific	ADJ
ct-9922	40	22	singlestrand	singlestrand	NOUN
ct-9922	40	23	break	break	NOUN
ct-9922	40	24	(	(	PUNCT
ct-9922	40	25	ssb	ssb	PROPN
ct-9922	40	26	)	)	PUNCT
ct-9922	40	27	without	without	ADP
ct-9922	40	28	causing	cause	VERB
ct-9922	40	29	dsb	dsb	NOUN
ct-9922	40	30	.	.	PUNCT
ct-9922	41	1	in	in	ADP
ct-9922	41	2	this	this	DET
ct-9922	41	3	study	study	NOUN
ct-9922	41	4	,	,	PUNCT
ct-9922	41	5	through	through	ADP
ct-9922	41	6	the	the	DET
ct-9922	41	7	zfnickases	zfnickase	NOUN
ct-9922	41	8	-	-	PUNCT
ct-9922	41	9	mediated	mediate	VERB
ct-9922	41	10	hdr	hdr	NOUN
ct-9922	41	11	,	,	PUNCT
ct-9922	41	12	the	the	DET
ct-9922	41	13	lysostaphin	lysostaphin	ADJ
ct-9922	41	14	gene	gene	NOUN
ct-9922	41	15	was	be	AUX
ct-9922	41	16	inserted	insert	VERB
ct-9922	41	17	into	into	ADP
ct-9922	41	18	the	the	DET
ct-9922	41	19	endogenous	endogenous	ADJ
ct-9922	41	20	β	β	NOUN
ct-9922	41	21	-	-	NOUN
ct-9922	41	22	casein	casein	NOUN
ct-9922	41	23	locus	locus	NOUN
ct-9922	41	24	(	(	PUNCT
ct-9922	41	25	csn2	csn2	PROPN
ct-9922	41	26	)	)	PUNCT
ct-9922	41	27	in	in	ADP
ct-9922	41	28	bovine	bovine	ADJ
ct-9922	41	29	fetal	fetal	ADJ
ct-9922	41	30	fibroblasts.35	fibroblasts.35	ADJ
ct-9922	41	31	lysostaphin	lysostaphin	NOUN
ct-9922	41	32	,	,	PUNCT
ct-9922	41	33	which	which	PRON
ct-9922	41	34	is	be	AUX
ct-9922	41	35	naturally	naturally	ADV
ct-9922	41	36	produced	produce	VERB
ct-9922	41	37	in	in	ADP
ct-9922	41	38	staphylococcus	staphylococcus	NOUN
ct-9922	41	39	simulans	simulan	NOUN
ct-9922	41	40	(	(	PUNCT
ct-9922	41	41	s.	s.	PROPN
ct-9922	41	42	simulans	simulans	PROPN
ct-9922	41	43	)	)	PUNCT
ct-9922	41	44	,	,	PUNCT
ct-9922	41	45	is	be	AUX
ct-9922	41	46	known	know	VERB
ct-9922	41	47	to	to	PART
ct-9922	41	48	be	be	AUX
ct-9922	41	49	effective	effective	ADJ
ct-9922	41	50	in	in	ADP
ct-9922	41	51	treating	treat	VERB
ct-9922	41	52	staphylococcus	staphylococcus	NOUN
ct-9922	41	53	aureus	aureus	NOUN
ct-9922	41	54	(	(	PUNCT
ct-9922	41	55	s.	s.	PROPN
ct-9922	41	56	aureus)-induced	aureus)-induced	PROPN
ct-9922	41	57	mastitis	mastitis	PROPN
ct-9922	41	58	,	,	PUNCT
ct-9922	41	59	the	the	DET
ct-9922	41	60	most	most	ADV
ct-9922	41	61	consequential	consequential	ADJ
ct-9922	41	62	disease	disease	NOUN
ct-9922	41	63	in	in	ADP
ct-9922	41	64	dairy	dairy	NOUN
ct-9922	41	65	cattle	cattle	NOUN
ct-9922	41	66	.	.	PUNCT
ct-9922	42	1	the	the	DET
ct-9922	42	2	lysostaphin	lysostaphin	ADJ
ct-9922	42	3	knock	knock	VERB
ct-9922	42	4	-	-	PUNCT
ct-9922	42	5	in	in	ADP
ct-9922	42	6	fibroblast	fibroblast	ADJ
ct-9922	42	7	cells	cell	NOUN
ct-9922	42	8	were	be	AUX
ct-9922	42	9	used	use	VERB
ct-9922	42	10	for	for	ADP
ct-9922	42	11	scnt	scnt	PRON
ct-9922	42	12	and	and	CCONJ
ct-9922	42	13	the	the	DET
ct-9922	42	14	gene	gene	NOUN
ct-9922	42	15	-	-	PUNCT
ct-9922	42	16	targeted	target	VERB
ct-9922	42	17	calves	calf	NOUN
ct-9922	42	18	were	be	AUX
ct-9922	42	19	born	bear	VERB
ct-9922	42	20	.	.	PUNCT
ct-9922	43	1	analysis	analysis	NOUN
ct-9922	43	2	of	of	ADP
ct-9922	43	3	milk	milk	NOUN
ct-9922	43	4	from	from	ADP
ct-9922	43	5	the	the	DET
ct-9922	43	6	cows	cow	NOUN
ct-9922	43	7	indicated	indicate	VERB
ct-9922	43	8	that	that	SCONJ
ct-9922	43	9	the	the	DET
ct-9922	43	10	lysostaphin	lysostaphin	NOUN
ct-9922	43	11	was	be	AUX
ct-9922	43	12	present	present	ADJ
ct-9922	43	13	in	in	ADP
ct-9922	43	14	the	the	DET
ct-9922	43	15	milk	milk	NOUN
ct-9922	43	16	and	and	CCONJ
ct-9922	43	17	in	in	ADP
ct-9922	43	18	vitro	vitro	X
ct-9922	43	19	assay	assay	PROPN
ct-9922	43	20	demonstrated	demonstrate	VERB
ct-9922	43	21	the	the	DET
ct-9922	43	22	milk	milk	NOUN
ct-9922	43	23	’s	’s	PART
ct-9922	43	24	ability	ability	NOUN
ct-9922	43	25	to	to	PART
ct-9922	43	26	kill	kill	VERB
ct-9922	43	27	s.	s.	PROPN
ct-9922	43	28	aureus	aureus	PROPN
ct-9922	43	29	.	.	PUNCT
ct-9922	44	1	the	the	DET
ct-9922	44	2	zfns	zfns	PROPN
ct-9922	44	3	were	be	AUX
ct-9922	44	4	also	also	ADV
ct-9922	44	5	applied	apply	VERB
ct-9922	44	6	to	to	PART
ct-9922	44	7	generate	generate	VERB
ct-9922	44	8	genetic	genetic	ADJ
ct-9922	44	9	engineered	engineer	VERB
ct-9922	44	10	pigs	pig	NOUN
ct-9922	44	11	for	for	ADP
ct-9922	44	12	agricultural	agricultural	ADJ
ct-9922	44	13	improvements	improvement	NOUN
ct-9922	44	14	.	.	PUNCT
ct-9922	45	1	myostatin	myostatin	NOUN
ct-9922	45	2	(	(	PUNCT
ct-9922	45	3	mstn	mstn	NOUN
ct-9922	45	4	)	)	PUNCT
ct-9922	45	5	gene	gene	NOUN
ct-9922	45	6	plays	play	VERB
ct-9922	45	7	a	a	DET
ct-9922	45	8	negative	negative	ADJ
ct-9922	45	9	regulatory	regulatory	ADJ
ct-9922	45	10	role	role	NOUN
ct-9922	45	11	in	in	ADP
ct-9922	45	12	muscle	muscle	NOUN
ct-9922	45	13	development	development	NOUN
ct-9922	45	14	and	and	CCONJ
ct-9922	45	15	naturally	naturally	ADV
ct-9922	45	16	occurring	occur	VERB
ct-9922	45	17	mutation	mutation	NOUN
ct-9922	45	18	in	in	ADP
ct-9922	45	19	mstn	mstn	NOUN
ct-9922	45	20	has	have	AUX
ct-9922	45	21	been	be	AUX
ct-9922	45	22	identified	identify	VERB
ct-9922	45	23	in	in	ADP
ct-9922	45	24	multiple	multiple	ADJ
ct-9922	45	25	species	specie	NOUN
ct-9922	45	26	such	such	ADJ
ct-9922	45	27	as	as	ADP
ct-9922	45	28	sheep36	sheep36	NOUN
ct-9922	45	29	and	and	CCONJ
ct-9922	45	30	cattle,37	cattle,37	VERB
ct-9922	45	31	famously	famously	ADV
ct-9922	45	32	known	know	VERB
ct-9922	45	33	in	in	ADP
ct-9922	45	34	the	the	DET
ct-9922	45	35	belgian	belgian	ADJ
ct-9922	45	36	blue	blue	ADJ
ct-9922	45	37	breed	breed	NOUN
ct-9922	45	38	of	of	ADP
ct-9922	45	39	cattle	cattle	NOUN
ct-9922	45	40	.	.	PUNCT
ct-9922	46	1	these	these	DET
ct-9922	46	2	animals	animal	NOUN
ct-9922	46	3	present	present	VERB
ct-9922	46	4	better	well	ADJ
ct-9922	46	5	feed	feed	NOUN
ct-9922	46	6	efficiency	efficiency	NOUN
ct-9922	46	7	,	,	PUNCT
ct-9922	46	8	growth	growth	NOUN
ct-9922	46	9	rate	rate	NOUN
ct-9922	46	10	,	,	PUNCT
ct-9922	46	11	and	and	CCONJ
ct-9922	46	12	higher	high	ADJ
ct-9922	46	13	muscle	muscle	NOUN
ct-9922	46	14	mass	mass	PROPN
ct-9922	46	15	.	.	PUNCT
ct-9922	47	1	this	this	DET
ct-9922	47	2	naturally	naturally	ADV
ct-9922	47	3	occurring	occur	VERB
ct-9922	47	4	mutation	mutation	NOUN
ct-9922	47	5	was	be	AUX
ct-9922	47	6	introduced	introduce	VERB
ct-9922	47	7	into	into	ADP
ct-9922	47	8	pigs	pig	NOUN
ct-9922	47	9	by	by	ADP
ct-9922	47	10	disrupting	disrupt	VERB
ct-9922	47	11	the	the	DET
ct-9922	47	12	mstn	mstn	NOUN
ct-9922	47	13	in	in	ADP
ct-9922	47	14	clinical	clinical	ADJ
ct-9922	47	15	theriogenology	theriogenology	NOUN
ct-9922	47	16	•	•	NOUN
ct-9922	47	17	volume	volume	NOUN
ct-9922	47	18	10	10	NUM
ct-9922	47	19	,	,	PUNCT
ct-9922	47	20	number	number	NOUN
ct-9922	47	21	3	3	NUM
ct-9922	47	22	•	•	NUM
ct-9922	47	23	september	september	PROPN
ct-9922	47	24	2018	2018	NUM
ct-9922	47	25	240	240	NUM
ct-9922	47	26	somatic	somatic	ADJ
ct-9922	47	27	cells	cell	NOUN
ct-9922	47	28	using	use	VERB
ct-9922	47	29	zfns	zfns	NOUN
ct-9922	47	30	followed	follow	VERB
ct-9922	47	31	by	by	ADP
ct-9922	47	32	scnt.38	scnt.38	PROPN
ct-9922	47	33	the	the	DET
ct-9922	47	34	mstn	mstn	NOUN
ct-9922	47	35	null	null	ADJ
ct-9922	47	36	pigs	pig	NOUN
ct-9922	47	37	displayed	display	VERB
ct-9922	47	38	higher	high	ADJ
ct-9922	47	39	growth	growth	NOUN
ct-9922	47	40	rate	rate	NOUN
ct-9922	47	41	and	and	CCONJ
ct-9922	47	42	increased	increase	VERB
ct-9922	47	43	muscle	muscle	NOUN
ct-9922	47	44	mass	mass	NOUN
ct-9922	47	45	compared	compare	VERB
ct-9922	47	46	to	to	ADP
ct-9922	47	47	wild	wild	ADJ
ct-9922	47	48	-	-	PUNCT
ct-9922	47	49	type	type	NOUN
ct-9922	47	50	control	control	NOUN
ct-9922	47	51	,	,	PUNCT
ct-9922	47	52	indicating	indicate	VERB
ct-9922	47	53	these	these	DET
ct-9922	47	54	line	line	NOUN
ct-9922	47	55	of	of	ADP
ct-9922	47	56	pigs	pig	NOUN
ct-9922	47	57	can	can	AUX
ct-9922	47	58	increase	increase	VERB
ct-9922	47	59	productivity	productivity	NOUN
ct-9922	47	60	,	,	PUNCT
ct-9922	47	61	if	if	SCONJ
ct-9922	47	62	incorporated	incorporate	VERB
ct-9922	47	63	into	into	ADP
ct-9922	47	64	production	production	NOUN
ct-9922	47	65	system	system	NOUN
ct-9922	47	66	.	.	PUNCT
ct-9922	48	1	as	as	SCONJ
ct-9922	48	2	shown	show	VERB
ct-9922	48	3	above	above	ADV
ct-9922	48	4	,	,	PUNCT
ct-9922	48	5	the	the	DET
ct-9922	48	6	use	use	NOUN
ct-9922	48	7	of	of	ADP
ct-9922	48	8	zfns	zfns	PROPN
ct-9922	48	9	significantly	significantly	ADV
ct-9922	48	10	increased	increase	VERB
ct-9922	48	11	the	the	DET
ct-9922	48	12	efficiency	efficiency	NOUN
ct-9922	48	13	of	of	ADP
ct-9922	48	14	generating	generate	VERB
ct-9922	48	15	genetically	genetically	ADV
ct-9922	48	16	engineered	engineer	VERB
ct-9922	48	17	livestock	livestock	NOUN
ct-9922	48	18	and	and	CCONJ
ct-9922	48	19	provided	provide	VERB
ct-9922	48	20	new	new	ADJ
ct-9922	48	21	opportunities	opportunity	NOUN
ct-9922	48	22	to	to	PART
ct-9922	48	23	design	design	VERB
ct-9922	48	24	animals	animal	NOUN
ct-9922	48	25	with	with	ADP
ct-9922	48	26	higher	high	ADJ
ct-9922	48	27	genetic	genetic	ADJ
ct-9922	48	28	values	value	NOUN
ct-9922	48	29	.	.	PUNCT
ct-9922	49	1	however	however	ADV
ct-9922	49	2	,	,	PUNCT
ct-9922	49	3	assembly	assembly	NOUN
ct-9922	49	4	of	of	ADP
ct-9922	49	5	zfns	zfns	PROPN
ct-9922	49	6	can	can	AUX
ct-9922	49	7	be	be	AUX
ct-9922	49	8	technically	technically	ADV
ct-9922	49	9	challenging	challenging	ADJ
ct-9922	49	10	,	,	PUNCT
ct-9922	49	11	and	and	CCONJ
ct-9922	49	12	effectiveness	effectiveness	NOUN
ct-9922	49	13	of	of	ADP
ct-9922	49	14	zfns	zfns	PROPN
ct-9922	49	15	was	be	AUX
ct-9922	49	16	limited	limit	VERB
ct-9922	49	17	to	to	ADP
ct-9922	49	18	gc	gc	PROPN
ct-9922	49	19	-	-	PUNCT
ct-9922	49	20	rich	rich	ADJ
ct-9922	49	21	regions	region	NOUN
ct-9922	49	22	of	of	ADP
ct-9922	49	23	the	the	DET
ct-9922	49	24	genome.39	genome.39	NOUN
ct-9922	49	25	genetically	genetically	ADV
ct-9922	49	26	engineered	engineer	VERB
ct-9922	49	27	livestock	livestock	NOUN
ct-9922	49	28	by	by	ADP
ct-9922	49	29	talens	talen	NOUN
ct-9922	49	30	transcription	transcription	NOUN
ct-9922	49	31	activator	activator	NOUN
ct-9922	49	32	-	-	PUNCT
ct-9922	49	33	like	like	ADJ
ct-9922	49	34	effector	effector	NOUN
ct-9922	49	35	nucleases	nuclease	NOUN
ct-9922	49	36	(	(	PUNCT
ct-9922	49	37	talens	talen	NOUN
ct-9922	49	38	)	)	PUNCT
ct-9922	49	39	are	be	AUX
ct-9922	49	40	designed	design	VERB
ct-9922	49	41	by	by	ADP
ct-9922	49	42	fusing	fuse	VERB
ct-9922	49	43	a	a	DET
ct-9922	49	44	tal	tal	X
ct-9922	49	45	effector	effector	NOUN
ct-9922	49	46	dna	dna	NOUN
ct-9922	49	47	binding	bind	VERB
ct-9922	49	48	domain	domain	NOUN
ct-9922	49	49	to	to	ADP
ct-9922	49	50	foki	foki	ADJ
ct-9922	49	51	enzyme	enzyme	NOUN
ct-9922	49	52	,	,	PUNCT
ct-9922	49	53	which	which	PRON
ct-9922	49	54	introduces	introduce	VERB
ct-9922	49	55	a	a	DET
ct-9922	49	56	dsb	dsb	NOUN
ct-9922	49	57	.	.	PUNCT
ct-9922	50	1	the	the	DET
ct-9922	50	2	tal	tal	PROPN
ct-9922	50	3	effector	effector	NOUN
ct-9922	50	4	was	be	AUX
ct-9922	50	5	originally	originally	ADV
ct-9922	50	6	isolated	isolate	VERB
ct-9922	50	7	from	from	ADP
ct-9922	50	8	plant	plant	NOUN
ct-9922	50	9	pathogenic	pathogenic	ADJ
ct-9922	50	10	bacteria	bacteria	NOUN
ct-9922	50	11	,	,	PUNCT
ct-9922	50	12	xanthomonas.40,41	xanthomonas.40,41	X
ct-9922	51	1	the	the	DET
ct-9922	51	2	binding	bind	VERB
ct-9922	51	3	specificity	specificity	NOUN
ct-9922	51	4	of	of	ADP
ct-9922	51	5	talen	talen	NOUN
ct-9922	51	6	is	be	AUX
ct-9922	51	7	determined	determine	VERB
ct-9922	51	8	by	by	ADP
ct-9922	51	9	a	a	DET
ct-9922	51	10	central	central	ADJ
ct-9922	51	11	domain	domain	NOUN
ct-9922	51	12	of	of	ADP
ct-9922	51	13	tandem	tandem	PROPN
ct-9922	51	14	,	,	PUNCT
ct-9922	51	15	33–35	33–35	NUM
ct-9922	51	16	amino	amino	NOUN
ct-9922	51	17	acid	acid	NOUN
ct-9922	51	18	repeats	repeat	NOUN
ct-9922	51	19	,	,	PUNCT
ct-9922	51	20	and	and	CCONJ
ct-9922	51	21	one	one	NUM
ct-9922	51	22	talen	talen	NOUN
ct-9922	51	23	motif	motif	NOUN
ct-9922	51	24	can	can	AUX
ct-9922	51	25	bind	bind	VERB
ct-9922	51	26	to	to	ADP
ct-9922	51	27	a	a	DET
ct-9922	51	28	single	single	ADJ
ct-9922	51	29	base	base	NOUN
ct-9922	51	30	pair.42,43	pair.42,43	NOUN
ct-9922	51	31	in	in	ADP
ct-9922	51	32	contrast	contrast	NOUN
ct-9922	51	33	to	to	ADP
ct-9922	51	34	the	the	DET
ct-9922	51	35	zfns	zfns	NOUN
ct-9922	51	36	,	,	PUNCT
ct-9922	51	37	talens	talen	NOUN
ct-9922	51	38	have	have	VERB
ct-9922	51	39	a	a	DET
ct-9922	51	40	greater	great	ADJ
ct-9922	51	41	design	design	NOUN
ct-9922	51	42	flexibility	flexibility	NOUN
ct-9922	51	43	with	with	ADP
ct-9922	51	44	the	the	DET
ct-9922	51	45	ability	ability	NOUN
ct-9922	51	46	of	of	ADP
ct-9922	51	47	single	single	ADJ
ct-9922	51	48	base	base	NOUN
ct-9922	51	49	recognition	recognition	NOUN
ct-9922	51	50	of	of	ADP
ct-9922	51	51	tal	tal	PROPN
ct-9922	51	52	effector	effector	NOUN
ct-9922	51	53	.	.	PUNCT
ct-9922	52	1	the	the	DET
ct-9922	52	2	first	first	ADJ
ct-9922	52	3	application	application	NOUN
ct-9922	52	4	of	of	ADP
ct-9922	52	5	talens	talen	NOUN
ct-9922	52	6	on	on	ADP
ct-9922	52	7	genetically	genetically	ADV
ct-9922	52	8	engineered	engineer	VERB
ct-9922	52	9	livestock	livestock	NOUN
ct-9922	52	10	production	production	NOUN
ct-9922	52	11	was	be	AUX
ct-9922	52	12	on	on	ADP
ct-9922	52	13	the	the	DET
ct-9922	52	14	pig	pig	NOUN
ct-9922	52	15	and	and	CCONJ
ct-9922	52	16	cattle	cattle	NOUN
ct-9922	52	17	.	.	PUNCT
ct-9922	53	1	use	use	NOUN
ct-9922	53	2	of	of	ADP
ct-9922	53	3	talens	talen	NOUN
ct-9922	53	4	effectively	effectively	ADV
ct-9922	53	5	introduced	introduce	VERB
ct-9922	53	6	targeted	target	VERB
ct-9922	53	7	modifications	modification	NOUN
ct-9922	53	8	in	in	ADP
ct-9922	53	9	somatic	somatic	ADJ
ct-9922	53	10	cells	cell	NOUN
ct-9922	53	11	,	,	PUNCT
ct-9922	53	12	as	as	ADV
ct-9922	53	13	well	well	ADV
ct-9922	53	14	as	as	ADP
ct-9922	53	15	in	in	ADP
ct-9922	53	16	embryos.27	embryos.27	PROPN
ct-9922	53	17	the	the	DET
ct-9922	53	18	paper	paper	NOUN
ct-9922	53	19	produced	produce	VERB
ct-9922	53	20	a	a	DET
ct-9922	53	21	pig	pig	NOUN
ct-9922	53	22	model	model	NOUN
ct-9922	53	23	for	for	ADP
ct-9922	53	24	human	human	ADJ
ct-9922	53	25	metabolic	metabolic	NOUN
ct-9922	53	26	syndromes	syndrome	NOUN
ct-9922	53	27	as	as	ADP
ct-9922	53	28	a	a	DET
ct-9922	53	29	proof	proof	NOUN
ct-9922	53	30	of	of	ADP
ct-9922	53	31	concept	concept	NOUN
ct-9922	53	32	.	.	PUNCT
ct-9922	54	1	the	the	DET
ct-9922	54	2	same	same	ADJ
ct-9922	54	3	group	group	NOUN
ct-9922	54	4	reported	report	VERB
ct-9922	54	5	the	the	DET
ct-9922	54	6	possibility	possibility	NOUN
ct-9922	54	7	of	of	ADP
ct-9922	54	8	introducing	introduce	VERB
ct-9922	54	9	the	the	DET
ct-9922	54	10	hornless	hornless	NOUN
ct-9922	54	11	phenotype	phenotype	NOUN
ct-9922	54	12	,	,	PUNCT
ct-9922	54	13	exists	exist	VERB
ct-9922	54	14	in	in	ADP
ct-9922	54	15	breeds	breed	NOUN
ct-9922	54	16	such	such	ADJ
ct-9922	54	17	as	as	ADP
ct-9922	54	18	angus,44	angus,44	NOUN
ct-9922	54	19	into	into	ADP
ct-9922	54	20	dairy	dairy	NOUN
ct-9922	54	21	cattle	cattle	NOUN
ct-9922	54	22	by	by	ADP
ct-9922	54	23	introgression	introgression	NOUN
ct-9922	54	24	of	of	ADP
ct-9922	54	25	a	a	DET
ct-9922	54	26	candidate	candidate	NOUN
ct-9922	54	27	polled	poll	VERB
ct-9922	54	28	allele	allele	NOUN
ct-9922	54	29	into	into	ADP
ct-9922	54	30	the	the	DET
ct-9922	54	31	genome	genome	NOUN
ct-9922	54	32	of	of	ADP
ct-9922	54	33	somatic	somatic	ADJ
ct-9922	54	34	cells	cell	NOUN
ct-9922	54	35	isolated	isolate	VERB
ct-9922	54	36	from	from	ADP
ct-9922	54	37	dairy	dairy	NOUN
ct-9922	54	38	cattle	cattle	NOUN
ct-9922	54	39	.	.	PUNCT
ct-9922	55	1	in	in	ADP
ct-9922	55	2	a	a	DET
ct-9922	55	3	follow	follow	VERB
ct-9922	55	4	-	-	PUNCT
ct-9922	55	5	up	up	ADP
ct-9922	55	6	study	study	NOUN
ct-9922	55	7	,	,	PUNCT
ct-9922	55	8	these	these	DET
ct-9922	55	9	cell	cell	NOUN
ct-9922	55	10	lines	line	NOUN
ct-9922	55	11	were	be	AUX
ct-9922	55	12	used	use	VERB
ct-9922	55	13	for	for	SCONJ
ct-9922	55	14	scnt	scnt	PRON
ct-9922	55	15	to	to	PART
ct-9922	55	16	produce	produce	VERB
ct-9922	55	17	five	five	NUM
ct-9922	55	18	hornless	hornless	NOUN
ct-9922	55	19	calves	calf	NOUN
ct-9922	55	20	,	,	PUNCT
ct-9922	55	21	which	which	PRON
ct-9922	55	22	,	,	PUNCT
ct-9922	55	23	as	as	SCONJ
ct-9922	55	24	expected	expect	VERB
ct-9922	55	25	,	,	PUNCT
ct-9922	55	26	presented	present	VERB
ct-9922	55	27	the	the	DET
ct-9922	55	28	hornless	hornless	NOUN
ct-9922	55	29	phenotype.45	phenotype.45	PROPN
ct-9922	55	30	physical	physical	ADJ
ct-9922	55	31	dehorning	dehorning	NOUN
ct-9922	55	32	of	of	ADP
ct-9922	55	33	cattle	cattle	NOUN
ct-9922	55	34	is	be	AUX
ct-9922	55	35	typically	typically	ADV
ct-9922	55	36	carried	carry	VERB
ct-9922	55	37	out	out	ADP
ct-9922	55	38	in	in	ADP
ct-9922	55	39	the	the	DET
ct-9922	55	40	dairy	dairy	NOUN
ct-9922	55	41	industry	industry	NOUN
ct-9922	55	42	to	to	PART
ct-9922	55	43	protect	protect	VERB
ct-9922	55	44	animals	animal	NOUN
ct-9922	55	45	and	and	CCONJ
ct-9922	55	46	producers	producer	NOUN
ct-9922	55	47	from	from	ADP
ct-9922	55	48	accidental	accidental	ADJ
ct-9922	55	49	injury	injury	NOUN
ct-9922	55	50	.	.	PUNCT
ct-9922	56	1	however	however	ADV
ct-9922	56	2	,	,	PUNCT
ct-9922	56	3	the	the	DET
ct-9922	56	4	process	process	NOUN
ct-9922	56	5	is	be	AUX
ct-9922	56	6	costly	costly	ADJ
ct-9922	56	7	and	and	CCONJ
ct-9922	56	8	painful	painful	ADJ
ct-9922	56	9	for	for	ADP
ct-9922	56	10	the	the	DET
ct-9922	56	11	animals	animal	NOUN
ct-9922	56	12	.	.	PUNCT
ct-9922	57	1	this	this	DET
ct-9922	57	2	talen	talen	NOUN
ct-9922	57	3	-	-	PUNCT
ct-9922	57	4	mediated	mediate	VERB
ct-9922	57	5	introgression	introgression	NOUN
ct-9922	57	6	of	of	ADP
ct-9922	57	7	a	a	DET
ct-9922	57	8	specific	specific	ADJ
ct-9922	57	9	allele	allele	NOUN
ct-9922	57	10	into	into	ADP
ct-9922	57	11	a	a	DET
ct-9922	57	12	breed	breed	NOUN
ct-9922	57	13	demonstrates	demonstrate	VERB
ct-9922	57	14	that	that	SCONJ
ct-9922	57	15	gene	gene	NOUN
ct-9922	57	16	-	-	PUNCT
ct-9922	57	17	editing	edit	VERB
ct-9922	57	18	technology	technology	NOUN
ct-9922	57	19	can	can	AUX
ct-9922	57	20	be	be	AUX
ct-9922	57	21	used	use	VERB
ct-9922	57	22	to	to	PART
ct-9922	57	23	improve	improve	VERB
ct-9922	57	24	economic	economic	ADJ
ct-9922	57	25	value	value	NOUN
ct-9922	57	26	to	to	ADP
ct-9922	57	27	producers	producer	NOUN
ct-9922	57	28	and	and	CCONJ
ct-9922	57	29	contribute	contribute	VERB
ct-9922	57	30	to	to	ADP
ct-9922	57	31	animal	animal	NOUN
ct-9922	57	32	welfare	welfare	NOUN
ct-9922	57	33	as	as	ADV
ct-9922	57	34	well	well	ADV
ct-9922	57	35	.	.	PUNCT
ct-9922	58	1	the	the	DET
ct-9922	58	2	talens	talen	NOUN
ct-9922	58	3	were	be	AUX
ct-9922	58	4	also	also	ADV
ct-9922	58	5	used	use	VERB
ct-9922	58	6	to	to	PART
ct-9922	58	7	generate	generate	VERB
ct-9922	58	8	pigs	pig	NOUN
ct-9922	58	9	carrying	carry	VERB
ct-9922	58	10	targeted	target	VERB
ct-9922	58	11	modifications	modification	NOUN
ct-9922	58	12	without	without	ADP
ct-9922	58	13	having	have	VERB
ct-9922	58	14	to	to	PART
ct-9922	58	15	apply	apply	VERB
ct-9922	58	16	scnt.28	scnt.28	NOUN
ct-9922	58	17	genetically	genetically	ADV
ct-9922	58	18	engineered	engineer	VERB
ct-9922	58	19	pigs	pig	NOUN
ct-9922	58	20	potentially	potentially	ADV
ct-9922	58	21	resistant	resistant	ADJ
ct-9922	58	22	to	to	ADP
ct-9922	58	23	african	african	ADJ
ct-9922	58	24	swine	swine	ADJ
ct-9922	58	25	fever	fever	NOUN
ct-9922	58	26	virus	virus	NOUN
ct-9922	58	27	were	be	AUX
ct-9922	58	28	produced	produce	VERB
ct-9922	58	29	by	by	ADP
ct-9922	58	30	direct	direct	ADJ
ct-9922	58	31	injection	injection	NOUN
ct-9922	58	32	of	of	ADP
ct-9922	58	33	talen	talen	ADJ
ct-9922	58	34	mrnas	mrna	NOUN
ct-9922	58	35	targeting	target	VERB
ct-9922	58	36	rela	rela	PROPN
ct-9922	58	37	gene	gene	NOUN
ct-9922	58	38	.	.	PUNCT
ct-9922	59	1	in	in	ADP
ct-9922	59	2	this	this	DET
ct-9922	59	3	study	study	NOUN
ct-9922	59	4	,	,	PUNCT
ct-9922	59	5	zfns	zfns	PROPN
ct-9922	59	6	were	be	AUX
ct-9922	59	7	also	also	ADV
ct-9922	59	8	able	able	ADJ
ct-9922	59	9	to	to	PART
ct-9922	59	10	introduce	introduce	VERB
ct-9922	59	11	a	a	DET
ct-9922	59	12	targeted	target	VERB
ct-9922	59	13	modification	modification	NOUN
ct-9922	59	14	in	in	ADP
ct-9922	59	15	the	the	DET
ct-9922	59	16	rela	rela	PROPN
ct-9922	59	17	region	region	NOUN
ct-9922	59	18	,	,	PUNCT
ct-9922	59	19	but	but	CCONJ
ct-9922	59	20	only	only	ADV
ct-9922	59	21	one	one	NUM
ct-9922	59	22	allele	allele	NOUN
ct-9922	59	23	was	be	AUX
ct-9922	59	24	modified	modify	VERB
ct-9922	59	25	through	through	ADP
ct-9922	59	26	zfns	zfns	PROPN
ct-9922	59	27	,	,	PUNCT
ct-9922	59	28	whereas	whereas	SCONJ
ct-9922	59	29	talens	talen	NOUN
ct-9922	59	30	were	be	AUX
ct-9922	59	31	able	able	ADJ
ct-9922	59	32	to	to	PART
ct-9922	59	33	disrupt	disrupt	VERB
ct-9922	59	34	both	both	DET
ct-9922	59	35	alleles	allele	NOUN
ct-9922	59	36	during	during	ADP
ct-9922	59	37	embryogenesis	embryogenesis	NOUN
ct-9922	59	38	.	.	PUNCT
ct-9922	60	1	this	this	PRON
ct-9922	60	2	was	be	AUX
ct-9922	60	3	the	the	DET
ct-9922	60	4	first	first	ADJ
ct-9922	60	5	report	report	NOUN
ct-9922	60	6	of	of	ADP
ct-9922	60	7	producing	produce	VERB
ct-9922	60	8	genetically	genetically	ADV
ct-9922	60	9	engineered	engineer	VERB
ct-9922	60	10	livestock	livestock	NOUN
ct-9922	60	11	with	with	ADP
ct-9922	60	12	site	site	NOUN
ct-9922	60	13	specific	specific	ADJ
ct-9922	60	14	modifications	modification	NOUN
ct-9922	60	15	without	without	ADP
ct-9922	60	16	having	have	VERB
ct-9922	60	17	to	to	PART
ct-9922	60	18	apply	apply	VERB
ct-9922	60	19	scnt	scnt	ADJ
ct-9922	60	20	.	.	PUNCT
ct-9922	61	1	similar	similar	ADJ
ct-9922	61	2	approaches	approach	NOUN
ct-9922	61	3	were	be	AUX
ct-9922	61	4	used	use	VERB
ct-9922	61	5	to	to	PART
ct-9922	61	6	generate	generate	VERB
ct-9922	61	7	mstn	mstn	NOUN
ct-9922	61	8	-	-	PUNCT
ct-9922	61	9	mutant	mutant	NOUN
ct-9922	61	10	cattle	cattle	NOUN
ct-9922	61	11	and	and	CCONJ
ct-9922	61	12	sheep.46	sheep.46	NOUN
ct-9922	61	13	in	in	ADP
ct-9922	61	14	this	this	DET
ct-9922	61	15	study	study	NOUN
ct-9922	61	16	,	,	PUNCT
ct-9922	61	17	oocytes	oocyte	NOUN
ct-9922	61	18	were	be	AUX
ct-9922	61	19	fertilized	fertilize	VERB
ct-9922	61	20	in	in	ADP
ct-9922	61	21	vitro	vitro	NOUN
ct-9922	61	22	,	,	PUNCT
ct-9922	61	23	and	and	CCONJ
ct-9922	61	24	then	then	ADV
ct-9922	61	25	talen	talen	ADJ
ct-9922	61	26	mrna	mrna	PROPN
ct-9922	61	27	targeting	target	VERB
ct-9922	61	28	mstn	mstn	NOUN
ct-9922	61	29	was	be	AUX
ct-9922	61	30	injected	inject	VERB
ct-9922	61	31	into	into	ADP
ct-9922	61	32	the	the	DET
ct-9922	61	33	zygotes	zygote	NOUN
ct-9922	61	34	.	.	PUNCT
ct-9922	62	1	the	the	DET
ct-9922	62	2	cultured	cultured	ADJ
ct-9922	62	3	blastocysts	blastocyst	NOUN
ct-9922	62	4	were	be	AUX
ct-9922	62	5	transferred	transfer	VERB
ct-9922	62	6	to	to	ADP
ct-9922	62	7	surrogates	surrogate	NOUN
ct-9922	62	8	and	and	CCONJ
ct-9922	62	9	live	live	ADJ
ct-9922	62	10	mstn	mstn	NOUN
ct-9922	62	11	-	-	PUNCT
ct-9922	62	12	mutant	mutant	ADJ
ct-9922	62	13	animals	animal	NOUN
ct-9922	62	14	were	be	AUX
ct-9922	62	15	born	bear	VERB
ct-9922	62	16	.	.	PUNCT
ct-9922	63	1	not	not	PART
ct-9922	63	2	all	all	DET
ct-9922	63	3	animals	animal	NOUN
ct-9922	63	4	showed	show	VERB
ct-9922	63	5	increased	increase	VERB
ct-9922	63	6	muscle	muscle	NOUN
ct-9922	63	7	phenotype	phenotype	NOUN
ct-9922	63	8	because	because	SCONJ
ct-9922	63	9	the	the	DET
ct-9922	63	10	modifications	modification	NOUN
ct-9922	63	11	introduced	introduce	VERB
ct-9922	63	12	by	by	ADP
ct-9922	63	13	talens	talen	NOUN
ct-9922	63	14	did	do	AUX
ct-9922	63	15	not	not	PART
ct-9922	63	16	cause	cause	VERB
ct-9922	63	17	a	a	DET
ct-9922	63	18	frame	frame	NOUN
ct-9922	63	19	shift	shift	NOUN
ct-9922	63	20	of	of	ADP
ct-9922	63	21	coding	code	VERB
ct-9922	63	22	sequences	sequence	NOUN
ct-9922	63	23	in	in	ADP
ct-9922	63	24	many	many	ADJ
ct-9922	63	25	of	of	ADP
ct-9922	63	26	the	the	DET
ct-9922	63	27	gene	gene	NOUN
ct-9922	63	28	-	-	PUNCT
ct-9922	63	29	edited	edit	VERB
ct-9922	63	30	animals	animal	NOUN
ct-9922	63	31	.	.	PUNCT
ct-9922	64	1	these	these	DET
ct-9922	64	2	studies	study	NOUN
ct-9922	64	3	demonstrated	demonstrate	VERB
ct-9922	64	4	that	that	SCONJ
ct-9922	64	5	zygote	zygote	ADJ
ct-9922	64	6	injection	injection	NOUN
ct-9922	64	7	of	of	ADP
ct-9922	64	8	talen	talen	ADJ
ct-9922	64	9	mrna	mrna	PROPN
ct-9922	64	10	can	can	AUX
ct-9922	64	11	be	be	AUX
ct-9922	64	12	an	an	DET
ct-9922	64	13	alternative	alternative	NOUN
ct-9922	64	14	to	to	ADP
ct-9922	64	15	the	the	DET
ct-9922	64	16	laborious	laborious	ADJ
ct-9922	64	17	and	and	CCONJ
ct-9922	64	18	technically	technically	ADV
ct-9922	64	19	difficult	difficult	ADJ
ct-9922	64	20	scnt	scnt	ADJ
ct-9922	64	21	technique	technique	NOUN
ct-9922	64	22	for	for	ADP
ct-9922	64	23	genetically	genetically	ADV
ct-9922	64	24	engineering	engineering	NOUN
ct-9922	64	25	livestock	livestock	NOUN
ct-9922	64	26	.	.	PUNCT
ct-9922	65	1	use	use	NOUN
ct-9922	65	2	of	of	ADP
ct-9922	65	3	talen	talen	NOUN
ct-9922	65	4	also	also	ADV
ct-9922	65	5	allowed	allow	VERB
ct-9922	65	6	for	for	ADP
ct-9922	65	7	generation	generation	NOUN
ct-9922	65	8	of	of	ADP
ct-9922	65	9	mstn	mstn	NOUN
ct-9922	65	10	-	-	PUNCT
ct-9922	65	11	mutant	mutant	NOUN
ct-9922	65	12	goats	goat	NOUN
ct-9922	65	13	by	by	ADP
ct-9922	65	14	a	a	DET
ct-9922	65	15	targeted	target	VERB
ct-9922	65	16	disruption	disruption	NOUN
ct-9922	65	17	of	of	ADP
ct-9922	65	18	mstn	mstn	NOUN
ct-9922	65	19	in	in	ADP
ct-9922	65	20	somatic	somatic	ADJ
ct-9922	65	21	cells	cell	NOUN
ct-9922	65	22	followed	follow	VERB
ct-9922	65	23	by	by	ADP
ct-9922	65	24	scnt.47	scnt.47	NOUN
ct-9922	65	25	similar	similar	ADJ
ct-9922	65	26	to	to	ADP
ct-9922	65	27	the	the	DET
ct-9922	65	28	application	application	NOUN
ct-9922	65	29	of	of	ADP
ct-9922	65	30	zfnickase	zfnickase	NOUN
ct-9922	65	31	,	,	PUNCT
ct-9922	65	32	transcription	transcription	NOUN
ct-9922	65	33	activator	activator	NOUN
ct-9922	65	34	-	-	PUNCT
ct-9922	65	35	like	like	ADJ
ct-9922	65	36	effector	effector	NOUN
ct-9922	65	37	nickase	nickase	NOUN
ct-9922	65	38	(	(	PUNCT
ct-9922	65	39	tale	tale	NOUN
ct-9922	65	40	nickase	nickase	NOUN
ct-9922	65	41	)	)	PUNCT
ct-9922	65	42	was	be	AUX
ct-9922	65	43	also	also	ADV
ct-9922	65	44	applied	apply	VERB
ct-9922	65	45	to	to	PART
ct-9922	65	46	introduce	introduce	VERB
ct-9922	65	47	a	a	DET
ct-9922	65	48	specific	specific	ADJ
ct-9922	65	49	gene	gene	NOUN
ct-9922	65	50	into	into	ADP
ct-9922	65	51	a	a	DET
ct-9922	65	52	specific	specific	ADJ
ct-9922	65	53	location	location	NOUN
ct-9922	65	54	of	of	ADP
ct-9922	65	55	the	the	DET
ct-9922	65	56	bovine	bovine	NOUN
ct-9922	65	57	genome	genome	NOUN
ct-9922	65	58	.	.	PUNCT
ct-9922	66	1	in	in	ADP
ct-9922	66	2	2015	2015	NUM
ct-9922	66	3	,	,	PUNCT
ct-9922	66	4	tale	tale	ADJ
ct-9922	66	5	nickase	nickase	NOUN
ct-9922	66	6	system	system	NOUN
ct-9922	66	7	was	be	AUX
ct-9922	66	8	used	use	VERB
ct-9922	66	9	to	to	PART
ct-9922	66	10	produce	produce	VERB
ct-9922	66	11	cattle	cattle	NOUN
ct-9922	66	12	resistant	resistant	ADJ
ct-9922	66	13	to	to	ADP
ct-9922	66	14	tuberculosis	tuberculosis	VERB
ct-9922	66	15	,	,	PUNCT
ct-9922	66	16	a	a	DET
ct-9922	66	17	chronic	chronic	ADJ
ct-9922	66	18	infectious	infectious	ADJ
ct-9922	66	19	disease	disease	NOUN
ct-9922	66	20	,	,	PUNCT
ct-9922	66	21	by	by	ADP
ct-9922	66	22	introducing	introduce	VERB
ct-9922	66	23	the	the	DET
ct-9922	66	24	sp110	sp110	PROPN
ct-9922	66	25	gene	gene	NOUN
ct-9922	66	26	under	under	ADP
ct-9922	66	27	the	the	DET
ct-9922	66	28	control	control	NOUN
ct-9922	66	29	of	of	ADP
ct-9922	66	30	a	a	DET
ct-9922	66	31	macrophage	macrophage	ADJ
ct-9922	66	32	specific	specific	ADJ
ct-9922	66	33	promoter	promoter	NOUN
ct-9922	66	34	,	,	PUNCT
ct-9922	66	35	macrophage	macrophage	ADJ
ct-9922	66	36	scavenger	scavenger	NOUN
ct-9922	66	37	receptor	receptor	NOUN
ct-9922	66	38	1	1	NUM
ct-9922	66	39	(	(	PUNCT
ct-9922	66	40	msr1	msr1	PROPN
ct-9922	66	41	)	)	PUNCT
ct-9922	66	42	promoter.48	promoter.48	VERB
ct-9922	66	43	expression	expression	NOUN
ct-9922	66	44	of	of	ADP
ct-9922	66	45	the	the	DET
ct-9922	66	46	sp110	sp110	PROPN
ct-9922	66	47	gene	gene	NOUN
ct-9922	66	48	,	,	PUNCT
ct-9922	66	49	obtained	obtain	VERB
ct-9922	66	50	from	from	ADP
ct-9922	66	51	tuberculosisresistant	tuberculosisresistant	ADJ
ct-9922	66	52	mouse	mouse	NOUN
ct-9922	66	53	strain	strain	NOUN
ct-9922	66	54	,	,	PUNCT
ct-9922	66	55	allowed	allow	VERB
ct-9922	66	56	the	the	DET
ct-9922	66	57	genetically	genetically	ADV
ct-9922	66	58	engineered	engineer	VERB
ct-9922	66	59	cows	cow	NOUN
ct-9922	66	60	to	to	PART
ct-9922	66	61	manage	manage	VERB
ct-9922	66	62	the	the	DET
ct-9922	66	63	growth	growth	NOUN
ct-9922	66	64	of	of	ADP
ct-9922	66	65	mycobacterium	mycobacterium	NOUN
ct-9922	66	66	bovis	bovis	NOUN
ct-9922	66	67	(	(	PUNCT
ct-9922	66	68	m.	m.	NOUN
ct-9922	66	69	bovis	bovis	NOUN
ct-9922	66	70	)	)	PUNCT
ct-9922	66	71	in	in	ADP
ct-9922	66	72	their	their	PRON
ct-9922	66	73	system	system	NOUN
ct-9922	66	74	and	and	CCONJ
ct-9922	66	75	efficiently	efficiently	ADV
ct-9922	66	76	be	be	AUX
ct-9922	66	77	resistant	resistant	ADJ
ct-9922	66	78	to	to	ADP
ct-9922	66	79	the	the	DET
ct-9922	66	80	low	low	ADJ
ct-9922	66	81	dose	dose	NOUN
ct-9922	66	82	of	of	ADP
ct-9922	66	83	m.	m.	NOUN
ct-9922	66	84	bovis	bovis	PROPN
ct-9922	66	85	.	.	PUNCT
ct-9922	67	1	application	application	NOUN
ct-9922	67	2	of	of	ADP
ct-9922	67	3	talens	talen	NOUN
ct-9922	67	4	expanded	expand	VERB
ct-9922	67	5	the	the	DET
ct-9922	67	6	production	production	NOUN
ct-9922	67	7	of	of	ADP
ct-9922	67	8	gene	gene	NOUN
ct-9922	67	9	-	-	PUNCT
ct-9922	67	10	edited	edit	VERB
ct-9922	67	11	animals	animal	NOUN
ct-9922	67	12	and	and	CCONJ
ct-9922	67	13	demonstrated	demonstrate	VERB
ct-9922	67	14	that	that	SCONJ
ct-9922	67	15	introducing	introduce	VERB
ct-9922	67	16	specific	specific	ADJ
ct-9922	67	17	mutations	mutation	NOUN
ct-9922	67	18	during	during	ADP
ct-9922	67	19	embryogenesis	embryogenesis	NOUN
ct-9922	67	20	was	be	AUX
ct-9922	67	21	possible	possible	ADJ
ct-9922	67	22	.	.	PUNCT
ct-9922	68	1	however	however	ADV
ct-9922	68	2	,	,	PUNCT
ct-9922	68	3	although	although	SCONJ
ct-9922	68	4	simper	simper	NOUN
ct-9922	68	5	than	than	ADP
ct-9922	68	6	zfn	zfn	PROPN
ct-9922	68	7	assembly	assembly	NOUN
ct-9922	68	8	,	,	PUNCT
ct-9922	68	9	constructing	construct	VERB
ct-9922	68	10	effective	effective	ADJ
ct-9922	68	11	talen	talen	NOUN
ct-9922	68	12	sets	set	NOUN
ct-9922	68	13	has	have	AUX
ct-9922	68	14	been	be	AUX
ct-9922	68	15	the	the	DET
ct-9922	68	16	main	main	ADJ
ct-9922	68	17	limitation	limitation	NOUN
ct-9922	68	18	on	on	ADP
ct-9922	68	19	the	the	DET
ct-9922	68	20	wide	wide	ADJ
ct-9922	68	21	use	use	NOUN
ct-9922	68	22	of	of	ADP
ct-9922	68	23	the	the	DET
ct-9922	68	24	technology	technology	NOUN
ct-9922	68	25	.	.	PUNCT
ct-9922	69	1	clinical	clinical	ADJ
ct-9922	69	2	theriogenology	theriogenology	NOUN
ct-9922	69	3	•	•	NOUN
ct-9922	69	4	volume	volume	NOUN
ct-9922	69	5	10	10	NUM
ct-9922	69	6	,	,	PUNCT
ct-9922	69	7	number	number	NOUN
ct-9922	69	8	3	3	NUM
ct-9922	69	9	•	•	NOUN
ct-9922	69	10	september	september	PROPN
ct-9922	69	11	2018241	2018241	NUM
ct-9922	69	12	genetically	genetically	ADV
ct-9922	69	13	engineered	engineer	VERB
ct-9922	69	14	livestock	livestock	NOUN
ct-9922	69	15	by	by	ADP
ct-9922	69	16	crispr	crispr	ADJ
ct-9922	69	17	/	/	SYM
ct-9922	69	18	cas9	cas9	NOUN
ct-9922	69	19	system	system	NOUN
ct-9922	69	20	clustered	cluster	VERB
ct-9922	69	21	regularly	regularly	ADV
ct-9922	69	22	interspaced	interspace	VERB
ct-9922	69	23	palindromic	palindromic	ADJ
ct-9922	69	24	repeats	repeat	NOUN
ct-9922	69	25	(	(	PUNCT
ct-9922	69	26	crispr	crispr	NOUN
ct-9922	69	27	)	)	PUNCT
ct-9922	69	28	is	be	AUX
ct-9922	69	29	an	an	DET
ct-9922	69	30	adaptive	adaptive	ADJ
ct-9922	69	31	immune	immune	ADJ
ct-9922	69	32	mechanism	mechanism	NOUN
ct-9922	69	33	presented	present	VERB
ct-9922	69	34	in	in	ADP
ct-9922	69	35	bacteria	bacteria	NOUN
ct-9922	69	36	cells	cell	NOUN
ct-9922	69	37	against	against	ADP
ct-9922	69	38	exogenous	exogenous	ADJ
ct-9922	69	39	dna	dna	NOUN
ct-9922	69	40	from	from	ADP
ct-9922	69	41	virus	virus	NOUN
ct-9922	69	42	or	or	CCONJ
ct-9922	69	43	plasmid.49,50	plasmid.49,50	VERB
ct-9922	69	44	the	the	DET
ct-9922	69	45	guide	guide	NOUN
ct-9922	69	46	sequences	sequence	NOUN
ct-9922	69	47	within	within	ADP
ct-9922	69	48	the	the	DET
ct-9922	69	49	crispr	crispr	ADJ
ct-9922	69	50	system	system	NOUN
ct-9922	69	51	,	,	PUNCT
ct-9922	69	52	which	which	PRON
ct-9922	69	53	corresponds	correspond	VERB
ct-9922	69	54	to	to	ADP
ct-9922	69	55	the	the	DET
ct-9922	69	56	viral	viral	ADJ
ct-9922	69	57	dna	dna	NOUN
ct-9922	69	58	,	,	PUNCT
ct-9922	69	59	can	can	AUX
ct-9922	69	60	be	be	AUX
ct-9922	69	61	easily	easily	ADV
ct-9922	69	62	replaced	replace	VERB
ct-9922	69	63	by	by	ADP
ct-9922	69	64	a	a	DET
ct-9922	69	65	target	target	NOUN
ct-9922	69	66	of	of	ADP
ct-9922	69	67	interest	interest	NOUN
ct-9922	69	68	.	.	PUNCT
ct-9922	70	1	this	this	DET
ct-9922	70	2	engineered	engineer	VERB
ct-9922	70	3	single	single	ADJ
ct-9922	70	4	guide	guide	NOUN
ct-9922	70	5	rna	rna	PROPN
ct-9922	70	6	(	(	PUNCT
ct-9922	70	7	sgrna	sgrna	PROPN
ct-9922	70	8	)	)	PUNCT
ct-9922	70	9	combined	combine	VERB
ct-9922	70	10	with	with	ADP
ct-9922	70	11	tracr	tracr	NOUN
ct-9922	70	12	-	-	PUNCT
ct-9922	70	13	rna	rna	NOUN
ct-9922	70	14	can	can	AUX
ct-9922	70	15	bind	bind	VERB
ct-9922	70	16	to	to	ADP
ct-9922	70	17	a	a	DET
ct-9922	70	18	target	target	NOUN
ct-9922	70	19	dna	dna	NOUN
ct-9922	70	20	sequence	sequence	NOUN
ct-9922	70	21	,	,	PUNCT
ct-9922	70	22	and	and	CCONJ
ct-9922	70	23	recruit	recruit	NOUN
ct-9922	70	24	cas9	cas9	NOUN
ct-9922	70	25	endonuclease	endonuclease	NOUN
ct-9922	70	26	protein	protein	NOUN
ct-9922	70	27	to	to	PART
ct-9922	70	28	induce	induce	VERB
ct-9922	70	29	dsb	dsb	NOUN
ct-9922	70	30	on	on	ADP
ct-9922	70	31	the	the	DET
ct-9922	70	32	target	target	NOUN
ct-9922	70	33	site.51,52	site.51,52	VERB
ct-9922	70	34	both	both	PRON
ct-9922	70	35	zfn	zfn	PROPN
ct-9922	70	36	and	and	CCONJ
ct-9922	70	37	talen	talen	ADJ
ct-9922	70	38	systems	system	NOUN
ct-9922	70	39	require	require	VERB
ct-9922	70	40	a	a	DET
ct-9922	70	41	series	series	NOUN
ct-9922	70	42	of	of	ADP
ct-9922	70	43	assembly	assembly	NOUN
ct-9922	70	44	to	to	PART
ct-9922	70	45	generate	generate	VERB
ct-9922	70	46	a	a	DET
ct-9922	70	47	construct	construct	NOUN
ct-9922	70	48	;	;	PUNCT
ct-9922	70	49	however	however	ADV
ct-9922	70	50	,	,	PUNCT
ct-9922	70	51	design	design	NOUN
ct-9922	70	52	of	of	ADP
ct-9922	70	53	20	20	NUM
ct-9922	70	54	bp	bp	PROPN
ct-9922	70	55	grna	grna	NOUN
ct-9922	70	56	for	for	ADP
ct-9922	70	57	the	the	DET
ct-9922	70	58	target	target	NOUN
ct-9922	70	59	sequence	sequence	NOUN
ct-9922	70	60	is	be	AUX
ct-9922	70	61	only	only	ADV
ct-9922	70	62	needed	need	VERB
ct-9922	70	63	to	to	PART
ct-9922	70	64	establish	establish	VERB
ct-9922	70	65	a	a	DET
ct-9922	70	66	crispr	crispr	ADJ
ct-9922	70	67	/	/	SYM
ct-9922	70	68	cas9	cas9	NOUN
ct-9922	70	69	system	system	NOUN
ct-9922	70	70	for	for	ADP
ct-9922	70	71	gene	gene	NOUN
ct-9922	70	72	-	-	PUNCT
ct-9922	70	73	editing	editing	NOUN
ct-9922	70	74	.	.	PUNCT
ct-9922	71	1	due	due	ADP
ct-9922	71	2	to	to	ADP
ct-9922	71	3	the	the	DET
ct-9922	71	4	simplicity	simplicity	NOUN
ct-9922	71	5	,	,	PUNCT
ct-9922	71	6	crispr	crispr	ADJ
ct-9922	71	7	/	/	SYM
ct-9922	71	8	cas9	cas9	NOUN
ct-9922	71	9	system	system	NOUN
ct-9922	71	10	has	have	AUX
ct-9922	71	11	become	become	VERB
ct-9922	71	12	the	the	DET
ct-9922	71	13	leading	lead	VERB
ct-9922	71	14	gene	gene	NOUN
ct-9922	71	15	-	-	PUNCT
ct-9922	71	16	editing	edit	VERB
ct-9922	71	17	system	system	NOUN
ct-9922	71	18	to	to	PART
ct-9922	71	19	develop	develop	VERB
ct-9922	71	20	gene	gene	NOUN
ct-9922	71	21	-	-	PUNCT
ct-9922	71	22	edited	edit	VERB
ct-9922	71	23	livestock	livestock	NOUN
ct-9922	71	24	.	.	PUNCT
ct-9922	72	1	the	the	DET
ct-9922	72	2	first	first	ADJ
ct-9922	72	3	application	application	NOUN
ct-9922	72	4	of	of	ADP
ct-9922	72	5	crispr	crispr	ADJ
ct-9922	72	6	/	/	SYM
ct-9922	72	7	cas9	cas9	NOUN
ct-9922	72	8	system	system	NOUN
ct-9922	72	9	in	in	ADP
ct-9922	72	10	livestock	livestock	NOUN
ct-9922	72	11	was	be	AUX
ct-9922	72	12	to	to	PART
ct-9922	72	13	produce	produce	VERB
ct-9922	72	14	a	a	DET
ct-9922	72	15	pig	pig	NOUN
ct-9922	72	16	model	model	NOUN
ct-9922	72	17	for	for	ADP
ct-9922	72	18	von	von	PROPN
ct-9922	72	19	willebrand	willebrand	PROPN
ct-9922	72	20	disease	disease	NOUN
ct-9922	72	21	in	in	ADP
ct-9922	72	22	humans.53	humans.53	PROPN
ct-9922	72	23	for	for	ADP
ct-9922	72	24	agricultural	agricultural	ADJ
ct-9922	72	25	purposes	purpose	NOUN
ct-9922	72	26	,	,	PUNCT
ct-9922	72	27	the	the	DET
ct-9922	72	28	first	first	ADJ
ct-9922	72	29	report	report	NOUN
ct-9922	72	30	was	be	AUX
ct-9922	72	31	to	to	PART
ct-9922	72	32	produce	produce	VERB
ct-9922	72	33	pigs	pig	NOUN
ct-9922	72	34	,	,	PUNCT
ct-9922	72	35	resistant	resistant	ADJ
ct-9922	72	36	to	to	PART
ct-9922	72	37	porcine	porcine	VERB
ct-9922	72	38	reproductive	reproductive	ADJ
ct-9922	72	39	and	and	CCONJ
ct-9922	72	40	respiratory	respiratory	ADJ
ct-9922	72	41	syndrome	syndrome	NOUN
ct-9922	72	42	(	(	PUNCT
ct-9922	72	43	prrs	prrs	PROPN
ct-9922	72	44	)	)	PUNCT
ct-9922	72	45	virus.54,55	virus.54,55	NOUN
ct-9922	72	46	although	although	SCONJ
ct-9922	72	47	prrs	prrs	NOUN
ct-9922	72	48	virus	virus	NOUN
ct-9922	72	49	causes	cause	VERB
ct-9922	72	50	substantial	substantial	ADJ
ct-9922	72	51	economic	economic	ADJ
ct-9922	72	52	losses	loss	NOUN
ct-9922	72	53	in	in	ADP
ct-9922	72	54	north	north	PROPN
ct-9922	72	55	america	america	PROPN
ct-9922	72	56	,	,	PUNCT
ct-9922	72	57	europe	europe	PROPN
ct-9922	72	58	,	,	PUNCT
ct-9922	72	59	and	and	CCONJ
ct-9922	72	60	asia	asia	PROPN
ct-9922	72	61	,	,	PUNCT
ct-9922	72	62	there	there	PRON
ct-9922	72	63	is	be	VERB
ct-9922	72	64	no	no	DET
ct-9922	72	65	effective	effective	ADJ
ct-9922	72	66	vaccine	vaccine	NOUN
ct-9922	72	67	against	against	ADP
ct-9922	72	68	the	the	DET
ct-9922	72	69	virus	virus	NOUN
ct-9922	72	70	.	.	PUNCT
ct-9922	73	1	piglets	piglet	NOUN
ct-9922	73	2	lacking	lack	VERB
ct-9922	73	3	functional	functional	ADJ
ct-9922	73	4	siglec1	siglec1	NOUN
ct-9922	73	5	(	(	PUNCT
ct-9922	73	6	cd169	cd169	PROPN
ct-9922	73	7	)	)	PUNCT
ct-9922	73	8	,	,	PUNCT
ct-9922	73	9	a	a	DET
ct-9922	73	10	candidate	candidate	NOUN
ct-9922	73	11	primary	primary	ADJ
ct-9922	73	12	viral	viral	ADJ
ct-9922	73	13	receptor	receptor	NOUN
ct-9922	73	14	for	for	ADP
ct-9922	73	15	prrs	prrs	NOUN
ct-9922	73	16	virus	virus	NOUN
ct-9922	73	17	infection	infection	NOUN
ct-9922	73	18	,	,	PUNCT
ct-9922	73	19	were	be	AUX
ct-9922	73	20	generated	generate	VERB
ct-9922	73	21	by	by	ADP
ct-9922	73	22	the	the	DET
ct-9922	73	23	conventional	conventional	ADJ
ct-9922	73	24	approach	approach	NOUN
ct-9922	73	25	without	without	ADP
ct-9922	73	26	the	the	DET
ct-9922	73	27	use	use	NOUN
ct-9922	73	28	of	of	ADP
ct-9922	73	29	gene	gene	NOUN
ct-9922	73	30	-	-	PUNCT
ct-9922	73	31	editing	edit	VERB
ct-9922	73	32	system.56	system.56	NOUN
ct-9922	73	33	establishing	establish	VERB
ct-9922	73	34	the	the	DET
ct-9922	73	35	pigs	pig	NOUN
ct-9922	73	36	required	require	VERB
ct-9922	73	37	two	two	NUM
ct-9922	73	38	breeding	breeding	NOUN
ct-9922	73	39	cycles	cycle	NOUN
ct-9922	73	40	because	because	SCONJ
ct-9922	73	41	only	only	ADV
ct-9922	73	42	one	one	NUM
ct-9922	73	43	siglec1	siglec1	PRON
ct-9922	73	44	allele	allele	NOUN
ct-9922	73	45	could	could	AUX
ct-9922	73	46	be	be	AUX
ct-9922	73	47	modified	modify	VERB
ct-9922	73	48	through	through	ADP
ct-9922	73	49	the	the	DET
ct-9922	73	50	conventional	conventional	ADJ
ct-9922	73	51	gene	gene	NOUN
ct-9922	73	52	targeting	target	VERB
ct-9922	73	53	approach	approach	NOUN
ct-9922	73	54	.	.	PUNCT
ct-9922	74	1	unfortunately	unfortunately	ADV
ct-9922	74	2	,	,	PUNCT
ct-9922	74	3	these	these	DET
ct-9922	74	4	pigs	pig	NOUN
ct-9922	74	5	were	be	AUX
ct-9922	74	6	not	not	PART
ct-9922	74	7	resistant	resistant	ADJ
ct-9922	74	8	to	to	ADP
ct-9922	74	9	the	the	DET
ct-9922	74	10	prrs	prrs	PROPN
ct-9922	74	11	virus	virus	PROPN
ct-9922	74	12	.	.	PUNCT
ct-9922	75	1	when	when	SCONJ
ct-9922	75	2	crispr	crispr	PROPN
ct-9922	75	3	/	/	SYM
ct-9922	75	4	cas9	cas9	NOUN
ct-9922	75	5	was	be	AUX
ct-9922	75	6	used	use	VERB
ct-9922	75	7	to	to	PART
ct-9922	75	8	disrupt	disrupt	VERB
ct-9922	75	9	cd163	cd163	PROPN
ct-9922	75	10	,	,	PUNCT
ct-9922	75	11	another	another	DET
ct-9922	75	12	putative	putative	ADJ
ct-9922	75	13	receptor	receptor	NOUN
ct-9922	75	14	for	for	ADP
ct-9922	75	15	prrs	prrs	NOUN
ct-9922	75	16	virus	virus	NOUN
ct-9922	75	17	,	,	PUNCT
ct-9922	75	18	cd163	cd163	PROPN
ct-9922	75	19	null	null	ADJ
ct-9922	75	20	pigs	pig	NOUN
ct-9922	75	21	were	be	AUX
ct-9922	75	22	established	establish	VERB
ct-9922	75	23	without	without	ADP
ct-9922	75	24	incorporating	incorporate	VERB
ct-9922	75	25	any	any	DET
ct-9922	75	26	breeding.55	breeding.55	NOUN
ct-9922	75	27	some	some	PRON
ct-9922	75	28	of	of	ADP
ct-9922	75	29	these	these	DET
ct-9922	75	30	pigs	pig	NOUN
ct-9922	75	31	were	be	AUX
ct-9922	75	32	generated	generate	VERB
ct-9922	75	33	by	by	ADP
ct-9922	75	34	injecting	inject	VERB
ct-9922	75	35	crispr	crispr	ADJ
ct-9922	75	36	/	/	SYM
ct-9922	75	37	cas9	cas9	NOUN
ct-9922	75	38	system	system	NOUN
ct-9922	75	39	into	into	ADP
ct-9922	75	40	fertilized	fertilize	VERB
ct-9922	75	41	embryos	embryos	NOUN
ct-9922	75	42	.	.	PUNCT
ct-9922	76	1	challenging	challenge	VERB
ct-9922	76	2	these	these	DET
ct-9922	76	3	pigs	pig	NOUN
ct-9922	76	4	with	with	ADP
ct-9922	76	5	prrs	prr	NOUN
ct-9922	76	6	virus	virus	NOUN
ct-9922	76	7	demonstrated	demonstrate	VERB
ct-9922	76	8	that	that	SCONJ
ct-9922	76	9	,	,	PUNCT
ct-9922	76	10	indeed	indeed	ADV
ct-9922	76	11	,	,	PUNCT
ct-9922	76	12	the	the	DET
ct-9922	76	13	cd163	cd163	PROPN
ct-9922	76	14	null	null	ADJ
ct-9922	76	15	piglets	piglet	NOUN
ct-9922	76	16	were	be	AUX
ct-9922	76	17	resistant	resistant	ADJ
ct-9922	76	18	to	to	ADP
ct-9922	76	19	prrs,54	prrs,54	NOUN
ct-9922	76	20	indicating	indicate	VERB
ct-9922	76	21	that	that	SCONJ
ct-9922	76	22	incorporation	incorporation	NOUN
ct-9922	76	23	of	of	ADP
ct-9922	76	24	these	these	DET
ct-9922	76	25	pigs	pig	NOUN
ct-9922	76	26	into	into	ADP
ct-9922	76	27	production	production	NOUN
ct-9922	76	28	can	can	AUX
ct-9922	76	29	dramatically	dramatically	ADV
ct-9922	76	30	reduce	reduce	VERB
ct-9922	76	31	economic	economic	ADJ
ct-9922	76	32	losses	loss	NOUN
ct-9922	76	33	associated	associate	VERB
ct-9922	76	34	with	with	ADP
ct-9922	76	35	the	the	DET
ct-9922	76	36	prrs	prrs	PROPN
ct-9922	76	37	virus	virus	NOUN
ct-9922	76	38	.	.	PUNCT
ct-9922	77	1	the	the	DET
ct-9922	77	2	first	first	ADJ
ct-9922	77	3	cd163	cd163	PROPN
ct-9922	77	4	knockout	knockout	NOUN
ct-9922	77	5	paper	paper	NOUN
ct-9922	77	6	also	also	ADV
ct-9922	77	7	proved	prove	VERB
ct-9922	77	8	that	that	SCONJ
ct-9922	77	9	direct	direct	ADJ
ct-9922	77	10	injection	injection	NOUN
ct-9922	77	11	of	of	ADP
ct-9922	77	12	crispr	crispr	ADJ
ct-9922	77	13	/	/	SYM
ct-9922	77	14	cas9	cas9	NOUN
ct-9922	77	15	system	system	NOUN
ct-9922	77	16	could	could	AUX
ct-9922	77	17	be	be	AUX
ct-9922	77	18	highly	highly	ADV
ct-9922	77	19	effective	effective	ADJ
ct-9922	77	20	in	in	ADP
ct-9922	77	21	generating	generate	VERB
ct-9922	77	22	knockout	knockout	NOUN
ct-9922	77	23	pigs	pig	NOUN
ct-9922	77	24	;	;	PUNCT
ct-9922	77	25	efficiencies	efficiency	NOUN
ct-9922	77	26	were	be	AUX
ct-9922	77	27	100	100	NUM
ct-9922	77	28	%	%	NOUN
ct-9922	77	29	in	in	ADP
ct-9922	77	30	the	the	DET
ct-9922	77	31	study	study	NOUN
ct-9922	77	32	.	.	PUNCT
ct-9922	78	1	using	use	VERB
ct-9922	78	2	a	a	DET
ct-9922	78	3	similar	similar	ADJ
ct-9922	78	4	approach	approach	NOUN
ct-9922	78	5	,	,	PUNCT
ct-9922	78	6	we	we	PRON
ct-9922	78	7	generated	generate	VERB
ct-9922	78	8	rag2	rag2	PROPN
ct-9922	78	9	/	/	SYM
ct-9922	78	10	il2rg	il2rg	NOUN
ct-9922	78	11	double	double	ADJ
ct-9922	78	12	knockout	knockout	NOUN
ct-9922	78	13	pigs	pig	NOUN
ct-9922	78	14	without	without	ADP
ct-9922	78	15	breeding	breeding	NOUN
ct-9922	78	16	or	or	CCONJ
ct-9922	78	17	scnt.57	scnt.57	PROPN
ct-9922	78	18	all	all	DET
ct-9922	78	19	seventeen	seventeen	NUM
ct-9922	78	20	pigs	pig	NOUN
ct-9922	78	21	produced	produce	VERB
ct-9922	78	22	through	through	ADP
ct-9922	78	23	the	the	DET
ct-9922	78	24	approaches	approach	NOUN
ct-9922	78	25	carried	carry	VERB
ct-9922	78	26	modification	modification	NOUN
ct-9922	78	27	on	on	ADP
ct-9922	78	28	both	both	DET
ct-9922	78	29	rag2	rag2	PROPN
ct-9922	78	30	and	and	CCONJ
ct-9922	78	31	il2rg	il2rg	NOUN
ct-9922	78	32	.	.	PUNCT
ct-9922	79	1	they	they	PRON
ct-9922	79	2	also	also	ADV
ct-9922	79	3	presented	present	VERB
ct-9922	79	4	expected	expect	VERB
ct-9922	79	5	phenotype	phenotype	NOUN
ct-9922	79	6	,	,	PUNCT
ct-9922	79	7	primary	primary	ADJ
ct-9922	79	8	immunodeficiency	immunodeficiency	NOUN
ct-9922	79	9	.	.	PUNCT
ct-9922	80	1	to	to	ADP
ct-9922	80	2	the	the	DET
ct-9922	80	3	best	good	ADJ
ct-9922	80	4	of	of	ADP
ct-9922	80	5	our	our	PRON
ct-9922	80	6	knowledge	knowledge	NOUN
ct-9922	80	7	,	,	PUNCT
ct-9922	80	8	this	this	PRON
ct-9922	80	9	was	be	AUX
ct-9922	80	10	the	the	DET
ct-9922	80	11	first	first	ADJ
ct-9922	80	12	report	report	NOUN
ct-9922	80	13	of	of	ADP
ct-9922	80	14	pigs	pig	NOUN
ct-9922	80	15	lacking	lack	VERB
ct-9922	80	16	all	all	DET
ct-9922	80	17	major	major	ADJ
ct-9922	80	18	lymphocytes	lymphocyte	NOUN
ct-9922	80	19	:	:	PUNCT
ct-9922	80	20	b	b	NUM
ct-9922	80	21	,	,	PUNCT
ct-9922	80	22	t	t	PROPN
ct-9922	80	23	,	,	PUNCT
ct-9922	80	24	and	and	CCONJ
ct-9922	80	25	nk	nk	PROPN
ct-9922	80	26	cells	cell	NOUN
ct-9922	80	27	.	.	PUNCT
ct-9922	81	1	the	the	DET
ct-9922	81	2	direct	direct	ADJ
ct-9922	81	3	injection	injection	NOUN
ct-9922	81	4	of	of	ADP
ct-9922	81	5	crispr	crispr	ADJ
ct-9922	81	6	/	/	SYM
ct-9922	81	7	cas9	cas9	NOUN
ct-9922	81	8	system	system	NOUN
ct-9922	81	9	indicates	indicate	VERB
ct-9922	81	10	that	that	SCONJ
ct-9922	81	11	scnt	scnt	PRON
ct-9922	81	12	may	may	AUX
ct-9922	81	13	not	not	PART
ct-9922	81	14	always	always	ADV
ct-9922	81	15	be	be	AUX
ct-9922	81	16	necessary	necessary	ADJ
ct-9922	81	17	to	to	PART
ct-9922	81	18	generate	generate	VERB
ct-9922	81	19	genetically	genetically	ADV
ct-9922	81	20	engineered	engineer	VERB
ct-9922	81	21	livestock	livestock	NOUN
ct-9922	81	22	carrying	carry	VERB
ct-9922	81	23	multiple	multiple	ADJ
ct-9922	81	24	gene	gene	NOUN
ct-9922	81	25	-	-	PUNCT
ct-9922	81	26	edits	edit	NOUN
ct-9922	81	27	,	,	PUNCT
ct-9922	81	28	thus	thus	ADV
ct-9922	81	29	avoiding	avoid	VERB
ct-9922	81	30	developmental	developmental	ADJ
ct-9922	81	31	abnormalities	abnormality	NOUN
ct-9922	81	32	associated	associate	VERB
ct-9922	81	33	with	with	ADP
ct-9922	81	34	scnt	scnt	NOUN
ct-9922	81	35	.	.	PUNCT
ct-9922	82	1	the	the	DET
ct-9922	82	2	study	study	NOUN
ct-9922	82	3	utilized	utilize	VERB
ct-9922	82	4	nhej	nhej	ADJ
ct-9922	82	5	to	to	PART
ct-9922	82	6	introduce	introduce	VERB
ct-9922	82	7	site	site	NOUN
ct-9922	82	8	-	-	PUNCT
ct-9922	82	9	specific	specific	ADJ
ct-9922	82	10	modifications	modification	NOUN
ct-9922	82	11	;	;	PUNCT
ct-9922	82	12	however	however	ADV
ct-9922	82	13	,	,	PUNCT
ct-9922	82	14	we	we	PRON
ct-9922	82	15	also	also	ADV
ct-9922	82	16	showed	show	VERB
ct-9922	82	17	that	that	SCONJ
ct-9922	82	18	exogenous	exogenous	ADJ
ct-9922	82	19	dna	dna	NOUN
ct-9922	82	20	fragment	fragment	NOUN
ct-9922	82	21	could	could	AUX
ct-9922	82	22	be	be	AUX
ct-9922	82	23	integrated	integrate	VERB
ct-9922	82	24	into	into	ADP
ct-9922	82	25	a	a	DET
ct-9922	82	26	specific	specific	ADJ
ct-9922	82	27	locus	locus	NOUN
ct-9922	82	28	through	through	ADP
ct-9922	82	29	hdr	hdr	NOUN
ct-9922	82	30	during	during	ADP
ct-9922	82	31	embryogenesis	embryogenesis	NOUN
ct-9922	82	32	in	in	ADP
ct-9922	82	33	pigs.58	pigs.58	ADJ
ct-9922	82	34	crispr	crispr	ADJ
ct-9922	82	35	/	/	SYM
ct-9922	82	36	cas9	cas9	NOUN
ct-9922	82	37	system	system	NOUN
ct-9922	82	38	has	have	AUX
ct-9922	82	39	also	also	ADV
ct-9922	82	40	been	be	AUX
ct-9922	82	41	applied	apply	VERB
ct-9922	82	42	to	to	PART
ct-9922	82	43	generate	generate	VERB
ct-9922	82	44	genetically	genetically	ADV
ct-9922	82	45	engineered	engineer	VERB
ct-9922	82	46	cattle	cattle	NOUN
ct-9922	82	47	to	to	PART
ct-9922	82	48	prevent	prevent	VERB
ct-9922	82	49	diseases	disease	NOUN
ct-9922	82	50	.	.	PUNCT
ct-9922	83	1	the	the	DET
ct-9922	83	2	bovine	bovine	PROPN
ct-9922	83	3	prnp	prnp	PROPN
ct-9922	83	4	gene	gene	NOUN
ct-9922	83	5	,	,	PUNCT
ct-9922	83	6	responsible	responsible	ADJ
ct-9922	83	7	for	for	ADP
ct-9922	83	8	mad	mad	ADJ
ct-9922	83	9	cow	cow	NOUN
ct-9922	83	10	disease	disease	NOUN
ct-9922	83	11	,	,	PUNCT
ct-9922	83	12	was	be	AUX
ct-9922	83	13	successfully	successfully	ADV
ct-9922	83	14	modified	modify	VERB
ct-9922	83	15	using	use	VERB
ct-9922	83	16	crispr	crispr	ADJ
ct-9922	83	17	/	/	SYM
ct-9922	83	18	cas9	cas9	NOUN
ct-9922	83	19	system,59	system,59	VERB
ct-9922	83	20	similar	similar	ADJ
ct-9922	83	21	to	to	ADP
ct-9922	83	22	a	a	DET
ct-9922	83	23	previous	previous	ADJ
ct-9922	83	24	study	study	NOUN
ct-9922	83	25	in	in	ADP
ct-9922	83	26	which	which	PRON
ct-9922	83	27	prnp	prnp	NOUN
ct-9922	83	28	gene	gene	NOUN
ct-9922	83	29	was	be	AUX
ct-9922	83	30	disrupted	disrupt	VERB
ct-9922	83	31	by	by	ADP
ct-9922	83	32	using	use	VERB
ct-9922	83	33	talen	talen	ADJ
ct-9922	83	34	system.60	system.60	PROPN
ct-9922	83	35	although	although	SCONJ
ct-9922	83	36	prnp	prnp	NOUN
ct-9922	83	37	-	-	PUNCT
ct-9922	83	38	mutant	mutant	ADJ
ct-9922	83	39	cattle	cattle	NOUN
ct-9922	83	40	have	have	AUX
ct-9922	83	41	not	not	PART
ct-9922	83	42	been	be	AUX
ct-9922	83	43	generated	generate	VERB
ct-9922	83	44	,	,	PUNCT
ct-9922	83	45	this	this	DET
ct-9922	83	46	study	study	NOUN
ct-9922	83	47	suggested	suggest	VERB
ct-9922	83	48	the	the	DET
ct-9922	83	49	possibility	possibility	NOUN
ct-9922	83	50	that	that	SCONJ
ct-9922	83	51	cattle	cattle	NOUN
ct-9922	83	52	with	with	ADP
ct-9922	83	53	a	a	DET
ct-9922	83	54	resistance	resistance	NOUN
ct-9922	83	55	to	to	ADP
ct-9922	83	56	mad	mad	ADJ
ct-9922	83	57	cow	cow	NOUN
ct-9922	83	58	disease	disease	NOUN
ct-9922	83	59	can	can	AUX
ct-9922	83	60	be	be	AUX
ct-9922	83	61	created	create	VERB
ct-9922	83	62	through	through	ADP
ct-9922	83	63	crispr	crispr	ADJ
ct-9922	83	64	/	/	SYM
ct-9922	83	65	cas9	cas9	NOUN
ct-9922	83	66	system	system	NOUN
ct-9922	83	67	.	.	PUNCT
ct-9922	84	1	more	more	ADV
ct-9922	84	2	importantly	importantly	ADV
ct-9922	84	3	,	,	PUNCT
ct-9922	84	4	the	the	DET
ct-9922	84	5	efficiency	efficiency	NOUN
ct-9922	84	6	of	of	ADP
ct-9922	84	7	targeted	target	VERB
ct-9922	84	8	disruptions	disruption	NOUN
ct-9922	84	9	in	in	ADP
ct-9922	84	10	these	these	DET
ct-9922	84	11	studies	study	NOUN
ct-9922	84	12	was	be	AUX
ct-9922	84	13	much	much	ADV
ct-9922	84	14	more	more	ADV
ct-9922	84	15	efficient	efficient	ADJ
ct-9922	84	16	compared	compare	VERB
ct-9922	84	17	to	to	ADP
ct-9922	84	18	publications	publication	NOUN
ct-9922	84	19	related	relate	VERB
ct-9922	84	20	to	to	ADP
ct-9922	84	21	the	the	DET
ct-9922	84	22	original	original	ADJ
ct-9922	84	23	production	production	NOUN
ct-9922	84	24	of	of	ADP
ct-9922	84	25	prnp	prnp	PROPN
ct-9922	84	26	knockout	knockout	NOUN
ct-9922	84	27	cattle.24	cattle.24	NOUN
ct-9922	84	28	,	,	PUNCT
ct-9922	84	29	61	61	NUM
ct-9922	84	30	in	in	ADP
ct-9922	84	31	addition	addition	NOUN
ct-9922	84	32	to	to	ADP
ct-9922	84	33	disrupting	disrupt	VERB
ct-9922	84	34	endogenous	endogenous	ADJ
ct-9922	84	35	genes	gene	NOUN
ct-9922	84	36	to	to	PART
ct-9922	84	37	improve	improve	VERB
ct-9922	84	38	disease	disease	NOUN
ct-9922	84	39	resistance	resistance	NOUN
ct-9922	84	40	,	,	PUNCT
ct-9922	84	41	crispr	crispr	ADJ
ct-9922	84	42	/	/	SYM
ct-9922	84	43	cas9	cas9	NOUN
ct-9922	84	44	system	system	NOUN
ct-9922	84	45	targeting	target	VERB
ct-9922	84	46	an	an	DET
ct-9922	84	47	african	african	ADJ
ct-9922	84	48	swine	swine	ADJ
ct-9922	84	49	fever	fever	NOUN
ct-9922	84	50	virus	virus	NOUN
ct-9922	84	51	gene	gene	NOUN
ct-9922	84	52	,	,	PUNCT
ct-9922	84	53	cp204l	cp204l	PROPN
ct-9922	84	54	,	,	PUNCT
ct-9922	84	55	was	be	AUX
ct-9922	84	56	incorporated	incorporate	VERB
ct-9922	84	57	into	into	ADP
ct-9922	84	58	the	the	DET
ct-9922	84	59	pig	pig	NOUN
ct-9922	84	60	genome	genome	NOUN
ct-9922	84	61	to	to	PART
ct-9922	84	62	effectively	effectively	ADV
ct-9922	84	63	prevent	prevent	VERB
ct-9922	84	64	the	the	DET
ct-9922	84	65	viral	viral	ADJ
ct-9922	84	66	infection	infection	NOUN
ct-9922	84	67	.	.	PUNCT
ct-9922	85	1	porcine	porcine	NOUN
ct-9922	85	2	cell	cell	NOUN
ct-9922	85	3	lines	line	NOUN
ct-9922	85	4	carrying	carry	VERB
ct-9922	85	5	the	the	DET
ct-9922	85	6	crispr	crispr	ADJ
ct-9922	85	7	/	/	SYM
ct-9922	85	8	cas9	cas9	NOUN
ct-9922	85	9	system	system	NOUN
ct-9922	85	10	was	be	AUX
ct-9922	85	11	resistant	resistant	ADJ
ct-9922	85	12	to	to	ADP
ct-9922	85	13	the	the	DET
ct-9922	85	14	african	african	ADJ
ct-9922	85	15	swine	swine	ADJ
ct-9922	85	16	fever	fever	NOUN
ct-9922	85	17	virus,62	virus,62	NOUN
ct-9922	85	18	indicating	indicate	VERB
ct-9922	85	19	the	the	DET
ct-9922	85	20	approach	approach	NOUN
ct-9922	85	21	can	can	AUX
ct-9922	85	22	be	be	AUX
ct-9922	85	23	used	use	VERB
ct-9922	85	24	to	to	PART
ct-9922	85	25	provide	provide	VERB
ct-9922	85	26	an	an	DET
ct-9922	85	27	enhanced	enhanced	ADJ
ct-9922	85	28	immunity	immunity	NOUN
ct-9922	85	29	to	to	ADP
ct-9922	85	30	pigs	pig	NOUN
ct-9922	85	31	.	.	PUNCT
ct-9922	86	1	above	above	ADP
ct-9922	86	2	examples	example	NOUN
ct-9922	86	3	focused	focus	VERB
ct-9922	86	4	on	on	ADP
ct-9922	86	5	generating	generate	VERB
ct-9922	86	6	gene	gene	NOUN
ct-9922	86	7	-	-	PUNCT
ct-9922	86	8	edited	edit	VERB
ct-9922	86	9	livestock	livestock	NOUN
ct-9922	86	10	for	for	ADP
ct-9922	86	11	disease	disease	NOUN
ct-9922	86	12	prevention	prevention	NOUN
ct-9922	86	13	.	.	PUNCT
ct-9922	87	1	the	the	DET
ct-9922	87	2	crispr	crispr	ADJ
ct-9922	87	3	/	/	SYM
ct-9922	87	4	cas9	cas9	NOUN
ct-9922	87	5	system	system	NOUN
ct-9922	87	6	was	be	AUX
ct-9922	87	7	also	also	ADV
ct-9922	87	8	used	use	VERB
ct-9922	87	9	to	to	PART
ct-9922	87	10	improve	improve	VERB
ct-9922	87	11	genetic	genetic	ADJ
ct-9922	87	12	value	value	NOUN
ct-9922	87	13	of	of	ADP
ct-9922	87	14	livestock	livestock	NOUN
ct-9922	87	15	by	by	ADP
ct-9922	87	16	introducing	introduce	VERB
ct-9922	87	17	or	or	CCONJ
ct-9922	87	18	replacing	replace	VERB
ct-9922	87	19	specific	specific	ADJ
ct-9922	87	20	dna	dna	NOUN
ct-9922	87	21	sequences	sequence	NOUN
ct-9922	87	22	.	.	PUNCT
ct-9922	88	1	the	the	DET
ct-9922	88	2	japanese	japanese	ADJ
ct-9922	88	3	black	black	ADJ
ct-9922	88	4	cattle	cattle	NOUN
ct-9922	88	5	breed	breed	NOUN
ct-9922	88	6	is	be	AUX
ct-9922	88	7	known	know	VERB
ct-9922	88	8	for	for	ADP
ct-9922	88	9	producing	produce	VERB
ct-9922	88	10	high	high	ADJ
ct-9922	88	11	quality	quality	NOUN
ct-9922	88	12	meat	meat	NOUN
ct-9922	88	13	.	.	PUNCT
ct-9922	89	1	however	however	ADV
ct-9922	89	2	,	,	PUNCT
ct-9922	89	3	the	the	DET
ct-9922	89	4	breed	breed	NOUN
ct-9922	89	5	is	be	AUX
ct-9922	89	6	susceptible	susceptible	ADJ
ct-9922	89	7	to	to	ADP
ct-9922	89	8	isoleucyl	isoleucyl	NOUN
ct-9922	89	9	-	-	PUNCT
ct-9922	89	10	trna	trna	NOUN
ct-9922	89	11	synthetase	synthetase	NOUN
ct-9922	89	12	(	(	PUNCT
ct-9922	89	13	iars	iar	NOUN
ct-9922	89	14	)	)	PUNCT
ct-9922	89	15	syndrome	syndrome	NOUN
ct-9922	89	16	,	,	PUNCT
ct-9922	89	17	a	a	DET
ct-9922	89	18	recessive	recessive	ADJ
ct-9922	89	19	disease	disease	NOUN
ct-9922	89	20	in	in	ADP
ct-9922	89	21	japanese	japanese	ADJ
ct-9922	89	22	black	black	ADJ
ct-9922	89	23	cattle	cattle	NOUN
ct-9922	89	24	caused	cause	VERB
ct-9922	89	25	by	by	ADP
ct-9922	89	26	a	a	DET
ct-9922	89	27	single	single	ADJ
ct-9922	89	28	nucleotide	nucleotide	NOUN
ct-9922	89	29	substitution.63	substitution.63	NOUN
ct-9922	89	30	the	the	DET
ct-9922	89	31	recessive	recessive	ADJ
ct-9922	89	32	genetic	genetic	ADJ
ct-9922	89	33	trait	trait	NOUN
ct-9922	89	34	was	be	AUX
ct-9922	89	35	successfully	successfully	ADV
ct-9922	89	36	replaced	replace	VERB
ct-9922	89	37	/	/	SYM
ct-9922	89	38	repaired	repair	VERB
ct-9922	89	39	by	by	ADP
ct-9922	89	40	utilizing	utilize	VERB
ct-9922	89	41	crispr	crispr	ADJ
ct-9922	89	42	/	/	SYM
ct-9922	89	43	cas9	cas9	NOUN
ct-9922	89	44	system.64	system.64	NOUN
ct-9922	89	45	the	the	DET
ct-9922	89	46	study	study	NOUN
ct-9922	89	47	demonstrates	demonstrate	VERB
ct-9922	89	48	that	that	SCONJ
ct-9922	89	49	harmful	harmful	ADJ
ct-9922	89	50	clinical	clinical	ADJ
ct-9922	89	51	theriogenology	theriogenology	NOUN
ct-9922	89	52	•	•	NOUN
ct-9922	89	53	volume	volume	NOUN
ct-9922	89	54	10	10	NUM
ct-9922	89	55	,	,	PUNCT
ct-9922	89	56	number	number	NOUN
ct-9922	89	57	3	3	NUM
ct-9922	89	58	•	•	NUM
ct-9922	89	59	september	september	PROPN
ct-9922	89	60	2018	2018	NUM
ct-9922	89	61	242	242	NUM
ct-9922	89	62	genetic	genetic	ADJ
ct-9922	89	63	traits	trait	NOUN
ct-9922	89	64	can	can	AUX
ct-9922	89	65	be	be	AUX
ct-9922	89	66	precisely	precisely	ADV
ct-9922	89	67	replaced	replace	VERB
ct-9922	89	68	,	,	PUNCT
ct-9922	89	69	while	while	SCONJ
ct-9922	89	70	keeping	keep	VERB
ct-9922	89	71	valuable	valuable	ADJ
ct-9922	89	72	genetic	genetic	ADJ
ct-9922	89	73	information	information	NOUN
ct-9922	89	74	unmodified	unmodified	ADJ
ct-9922	89	75	.	.	PUNCT
ct-9922	90	1	similarly	similarly	ADV
ct-9922	90	2	,	,	PUNCT
ct-9922	90	3	gene	gene	NOUN
ct-9922	90	4	-	-	PUNCT
ct-9922	90	5	edited	edit	VERB
ct-9922	90	6	pigs	pig	NOUN
ct-9922	90	7	that	that	PRON
ct-9922	90	8	have	have	AUX
ct-9922	90	9	improved	improve	VERB
ct-9922	90	10	thermogenesis	thermogenesis	NOUN
ct-9922	90	11	capability	capability	NOUN
ct-9922	90	12	were	be	AUX
ct-9922	90	13	produced	produce	VERB
ct-9922	90	14	by	by	ADP
ct-9922	90	15	replacing	replace	VERB
ct-9922	90	16	endogenous	endogenous	ADJ
ct-9922	90	17	uncoupling	uncoupling	NOUN
ct-9922	90	18	protein	protein	NOUN
ct-9922	90	19	1	1	NUM
ct-9922	90	20	(	(	PUNCT
ct-9922	90	21	ucp1	ucp1	ADJ
ct-9922	90	22	)	)	PUNCT
ct-9922	90	23	gene	gene	NOUN
ct-9922	90	24	,	,	PUNCT
ct-9922	90	25	known	know	VERB
ct-9922	90	26	to	to	PART
ct-9922	90	27	be	be	AUX
ct-9922	90	28	a	a	DET
ct-9922	90	29	key	key	ADJ
ct-9922	90	30	element	element	NOUN
ct-9922	90	31	for	for	ADP
ct-9922	90	32	brown	brown	ADJ
ct-9922	90	33	adipose	adipose	PRON
ct-9922	90	34	tissue	tissue	NOUN
ct-9922	90	35	-	-	PUNCT
ct-9922	90	36	mediated	mediate	VERB
ct-9922	90	37	thermogenesis	thermogenesis	NOUN
ct-9922	90	38	and	and	CCONJ
ct-9922	90	39	regulating	regulate	VERB
ct-9922	90	40	energy	energy	NOUN
ct-9922	90	41	homeostasis	homeostasis	NOUN
ct-9922	90	42	,	,	PUNCT
ct-9922	90	43	by	by	ADP
ct-9922	90	44	utilizing	utilize	VERB
ct-9922	90	45	crispr	crispr	ADJ
ct-9922	90	46	/	/	SYM
ct-9922	90	47	cas9	cas9	NOUN
ct-9922	90	48	system.65	system.65	NOUN
ct-9922	90	49	pigs	pig	NOUN
ct-9922	90	50	have	have	AUX
ct-9922	90	51	lost	lose	VERB
ct-9922	90	52	functional	functional	ADJ
ct-9922	90	53	ucp1	ucp1	NOUN
ct-9922	90	54	during	during	ADP
ct-9922	90	55	evolution	evolution	NOUN
ct-9922	90	56	,	,	PUNCT
ct-9922	90	57	thus	thus	ADV
ct-9922	90	58	showing	show	VERB
ct-9922	90	59	susceptibility	susceptibility	NOUN
ct-9922	90	60	to	to	PART
ct-9922	90	61	cold	cold	VERB
ct-9922	90	62	,	,	PUNCT
ct-9922	90	63	which	which	PRON
ct-9922	90	64	leads	lead	VERB
ct-9922	90	65	to	to	ADP
ct-9922	90	66	high	high	ADJ
ct-9922	90	67	neonatal	neonatal	ADJ
ct-9922	90	68	mortality	mortality	NOUN
ct-9922	90	69	and	and	CCONJ
ct-9922	90	70	decreased	decrease	VERB
ct-9922	90	71	production	production	NOUN
ct-9922	90	72	efficiency	efficiency	NOUN
ct-9922	90	73	.	.	PUNCT
ct-9922	91	1	in	in	ADP
ct-9922	91	2	this	this	DET
ct-9922	91	3	study	study	NOUN
ct-9922	91	4	,	,	PUNCT
ct-9922	91	5	first	first	ADJ
ct-9922	91	6	adiponectin	adiponectin	NOUN
ct-9922	91	7	promoter	promoter	NOUN
ct-9922	91	8	driven	drive	VERB
ct-9922	91	9	mouse	mouse	PROPN
ct-9922	91	10	ucp1	ucp1	PROPN
ct-9922	91	11	gene	gene	NOUN
ct-9922	91	12	was	be	AUX
ct-9922	91	13	inserted	insert	VERB
ct-9922	91	14	into	into	ADP
ct-9922	91	15	the	the	DET
ct-9922	91	16	endogenous	endogenous	ADJ
ct-9922	91	17	porcine	porcine	NOUN
ct-9922	91	18	ucp1	ucp1	NOUN
ct-9922	91	19	locus	locus	NOUN
ct-9922	91	20	through	through	ADP
ct-9922	91	21	crispr	crispr	NOUN
ct-9922	91	22	/	/	SYM
ct-9922	91	23	cas9	cas9	NOUN
ct-9922	91	24	-	-	PUNCT
ct-9922	91	25	mediated	mediate	VERB
ct-9922	91	26	gene	gene	NOUN
ct-9922	91	27	insertion	insertion	NOUN
ct-9922	91	28	in	in	ADP
ct-9922	91	29	porcine	porcine	NOUN
ct-9922	91	30	fetal	fetal	ADJ
ct-9922	91	31	fibroblast	fibroblast	ADJ
ct-9922	91	32	cells	cell	NOUN
ct-9922	91	33	.	.	PUNCT
ct-9922	92	1	then	then	ADV
ct-9922	92	2	,	,	PUNCT
ct-9922	92	3	murine	murine	ADJ
ct-9922	92	4	ucp1	ucp1	ADJ
ct-9922	92	5	overexpressing	overexpresse	VERB
ct-9922	92	6	pigs	pig	NOUN
ct-9922	92	7	were	be	AUX
ct-9922	92	8	produced	produce	VERB
ct-9922	92	9	by	by	ADP
ct-9922	92	10	scnt	scnt	NOUN
ct-9922	92	11	using	use	VERB
ct-9922	92	12	the	the	DET
ct-9922	92	13	cells	cell	NOUN
ct-9922	92	14	.	.	PUNCT
ct-9922	93	1	the	the	DET
ct-9922	93	2	gene	gene	NOUN
ct-9922	93	3	-	-	PUNCT
ct-9922	93	4	edited	edit	VERB
ct-9922	93	5	pigs	pig	NOUN
ct-9922	93	6	showed	show	VERB
ct-9922	93	7	improved	improved	ADJ
ct-9922	93	8	ability	ability	NOUN
ct-9922	93	9	to	to	PART
ct-9922	93	10	maintain	maintain	VERB
ct-9922	93	11	body	body	NOUN
ct-9922	93	12	temperature	temperature	NOUN
ct-9922	93	13	,	,	PUNCT
ct-9922	93	14	decreased	decrease	VERB
ct-9922	93	15	fat	fat	ADJ
ct-9922	93	16	deposition	deposition	NOUN
ct-9922	93	17	,	,	PUNCT
ct-9922	93	18	and	and	CCONJ
ct-9922	93	19	increased	increase	VERB
ct-9922	93	20	carcass	carcass	NOUN
ct-9922	93	21	lean	lean	ADJ
ct-9922	93	22	percentage	percentage	NOUN
ct-9922	93	23	.	.	PUNCT
ct-9922	94	1	this	this	DET
ct-9922	94	2	report	report	NOUN
ct-9922	94	3	indicates	indicate	VERB
ct-9922	94	4	that	that	SCONJ
ct-9922	94	5	gene	gene	NOUN
ct-9922	94	6	-	-	PUNCT
ct-9922	94	7	editing	edit	VERB
ct-9922	94	8	technology	technology	NOUN
ct-9922	94	9	can	can	AUX
ct-9922	94	10	improve	improve	VERB
ct-9922	94	11	genetic	genetic	ADJ
ct-9922	94	12	value	value	NOUN
ct-9922	94	13	of	of	ADP
ct-9922	94	14	pigs	pig	NOUN
ct-9922	94	15	,	,	PUNCT
ct-9922	94	16	production	production	NOUN
ct-9922	94	17	efficiency	efficiency	NOUN
ct-9922	94	18	,	,	PUNCT
ct-9922	94	19	and	and	CCONJ
ct-9922	94	20	animal	animal	NOUN
ct-9922	94	21	welfare	welfare	NOUN
ct-9922	94	22	.	.	PUNCT
ct-9922	95	1	conclusion	conclusion	NOUN
ct-9922	95	2	the	the	DET
ct-9922	95	3	use	use	NOUN
ct-9922	95	4	of	of	ADP
ct-9922	95	5	gene	gene	NOUN
ct-9922	95	6	-	-	PUNCT
ct-9922	95	7	editing	edit	VERB
ct-9922	95	8	systems	system	NOUN
ct-9922	95	9	has	have	AUX
ct-9922	95	10	provided	provide	VERB
ct-9922	95	11	new	new	ADJ
ct-9922	95	12	opportunities	opportunity	NOUN
ct-9922	95	13	to	to	PART
ct-9922	95	14	improve	improve	VERB
ct-9922	95	15	the	the	DET
ct-9922	95	16	genetic	genetic	ADJ
ct-9922	95	17	value	value	NOUN
ct-9922	95	18	of	of	ADP
ct-9922	95	19	livestock	livestock	NOUN
ct-9922	95	20	.	.	PUNCT
ct-9922	96	1	due	due	ADP
ct-9922	96	2	to	to	ADP
ct-9922	96	3	available	available	ADJ
ct-9922	96	4	funding	funding	NOUN
ct-9922	96	5	opportunities	opportunity	NOUN
ct-9922	96	6	,	,	PUNCT
ct-9922	96	7	most	most	ADJ
ct-9922	96	8	gene	gene	NOUN
ct-9922	96	9	-	-	PUNCT
ct-9922	96	10	edited	edit	VERB
ct-9922	96	11	livestock	livestock	NOUN
ct-9922	96	12	is	be	AUX
ct-9922	96	13	generated	generate	VERB
ct-9922	96	14	for	for	ADP
ct-9922	96	15	biomedical	biomedical	ADJ
ct-9922	96	16	purposes.26,57,66	purposes.26,57,66	NOUN
ct-9922	96	17	-	-	PUNCT
ct-9922	96	18	69	69	NUM
ct-9922	96	19	however	however	ADV
ct-9922	96	20	,	,	PUNCT
ct-9922	96	21	examples	example	NOUN
ct-9922	96	22	introduced	introduce	VERB
ct-9922	96	23	here	here	ADV
ct-9922	96	24	certainly	certainly	ADV
ct-9922	96	25	illustrate	illustrate	VERB
ct-9922	96	26	the	the	DET
ct-9922	96	27	potential	potential	ADJ
ct-9922	96	28	impact	impact	NOUN
ct-9922	96	29	of	of	ADP
ct-9922	96	30	geneedited	geneedite	VERB
ct-9922	96	31	livestock	livestock	NOUN
ct-9922	96	32	in	in	ADP
ct-9922	96	33	the	the	DET
ct-9922	96	34	agriculture	agriculture	NOUN
ct-9922	96	35	industry	industry	NOUN
ct-9922	96	36	and	and	CCONJ
ct-9922	96	37	an	an	DET
ct-9922	96	38	upcoming	upcoming	ADJ
ct-9922	96	39	line	line	NOUN
ct-9922	96	40	of	of	ADP
ct-9922	96	41	animals	animal	NOUN
ct-9922	96	42	that	that	PRON
ct-9922	96	43	may	may	AUX
ct-9922	96	44	be	be	AUX
ct-9922	96	45	introduced	introduce	VERB
ct-9922	96	46	into	into	ADP
ct-9922	96	47	the	the	DET
ct-9922	96	48	food	food	NOUN
ct-9922	96	49	production	production	NOUN
ct-9922	96	50	system	system	NOUN
ct-9922	96	51	.	.	PUNCT
ct-9922	97	1	many	many	ADJ
ct-9922	97	2	of	of	ADP
ct-9922	97	3	the	the	DET
ct-9922	97	4	gene	gene	NOUN
ct-9922	97	5	-	-	PUNCT
ct-9922	97	6	edited	edit	VERB
ct-9922	97	7	animals	animal	NOUN
ct-9922	97	8	only	only	ADV
ct-9922	97	9	rely	rely	VERB
ct-9922	97	10	on	on	ADP
ct-9922	97	11	endogenous	endogenous	ADJ
ct-9922	97	12	nhej	nhej	ADJ
ct-9922	97	13	pathway	pathway	NOUN
ct-9922	97	14	to	to	PART
ct-9922	97	15	introduce	introduce	VERB
ct-9922	97	16	targeted	target	VERB
ct-9922	97	17	modification	modification	NOUN
ct-9922	97	18	,	,	PUNCT
ct-9922	97	19	thus	thus	ADV
ct-9922	97	20	no	no	DET
ct-9922	97	21	foot	foot	NOUN
ct-9922	97	22	-	-	PUNCT
ct-9922	97	23	print	print	NOUN
ct-9922	97	24	remained	remain	VERB
ct-9922	97	25	in	in	ADP
ct-9922	97	26	their	their	PRON
ct-9922	97	27	genome	genome	NOUN
ct-9922	97	28	.	.	PUNCT
ct-9922	98	1	because	because	SCONJ
ct-9922	98	2	there	there	PRON
ct-9922	98	3	is	be	VERB
ct-9922	98	4	no	no	DET
ct-9922	98	5	integration	integration	NOUN
ct-9922	98	6	of	of	ADP
ct-9922	98	7	exogenous	exogenous	ADJ
ct-9922	98	8	dna	dna	NOUN
ct-9922	98	9	sequence	sequence	NOUN
ct-9922	98	10	,	,	PUNCT
ct-9922	98	11	the	the	DET
ct-9922	98	12	word	word	NOUN
ct-9922	98	13	‘	'	PUNCT
ct-9922	98	14	transgenic	transgenic	NOUN
ct-9922	98	15	’	'	PUNCT
ct-9922	98	16	does	do	AUX
ct-9922	98	17	not	not	PART
ct-9922	98	18	apply	apply	VERB
ct-9922	98	19	to	to	ADP
ct-9922	98	20	these	these	DET
ct-9922	98	21	animals	animal	NOUN
ct-9922	98	22	.	.	PUNCT
ct-9922	99	1	the	the	DET
ct-9922	99	2	fda	fda	PROPN
ct-9922	99	3	approval	approval	NOUN
ct-9922	99	4	of	of	ADP
ct-9922	99	5	transgenic	transgenic	NOUN
ct-9922	99	6	salmon	salmon	NOUN
ct-9922	99	7	also	also	ADV
ct-9922	99	8	suggests	suggest	VERB
ct-9922	99	9	that	that	SCONJ
ct-9922	99	10	more	more	ADV
ct-9922	99	11	genetically	genetically	ADV
ct-9922	99	12	engineered	engineer	VERB
ct-9922	99	13	or	or	CCONJ
ct-9922	99	14	gene	gene	NOUN
ct-9922	99	15	-	-	PUNCT
ct-9922	99	16	edited	edit	VERB
ct-9922	99	17	animal	animal	NOUN
ct-9922	99	18	products	product	NOUN
ct-9922	99	19	may	may	AUX
ct-9922	99	20	be	be	AUX
ct-9922	99	21	introduced	introduce	VERB
ct-9922	99	22	into	into	ADP
ct-9922	99	23	the	the	DET
ct-9922	99	24	food	food	NOUN
ct-9922	99	25	production	production	NOUN
ct-9922	99	26	system.70	system.70	NOUN
ct-9922	99	27	the	the	DET
ct-9922	99	28	development	development	NOUN
ct-9922	99	29	of	of	ADP
ct-9922	99	30	gene	gene	NOUN
ct-9922	99	31	-	-	PUNCT
ct-9922	99	32	editing	edit	VERB
ct-9922	99	33	technology	technology	NOUN
ct-9922	99	34	will	will	AUX
ct-9922	99	35	certainly	certainly	ADV
ct-9922	99	36	lower	lower	VERB
ct-9922	99	37	the	the	DET
ct-9922	99	38	existing	exist	VERB
ct-9922	99	39	barriers	barrier	NOUN
ct-9922	99	40	in	in	ADP
ct-9922	99	41	producing	produce	VERB
ct-9922	99	42	genetically	genetically	ADV
ct-9922	99	43	engineered	engineer	VERB
ct-9922	99	44	livestock	livestock	NOUN
ct-9922	99	45	,	,	PUNCT
ct-9922	99	46	thus	thus	ADV
ct-9922	99	47	widening	widen	VERB
ct-9922	99	48	the	the	DET
ct-9922	99	49	use	use	NOUN
ct-9922	99	50	of	of	ADP
ct-9922	99	51	genetically	genetically	ADV
ct-9922	99	52	engineered	engineer	VERB
ct-9922	99	53	livestock	livestock	NOUN
ct-9922	99	54	in	in	ADP
ct-9922	99	55	agriculture	agriculture	NOUN
ct-9922	99	56	.	.	PUNCT
ct-9922	100	1	references	reference	NOUN
ct-9922	100	2	1	1	NUM
ct-9922	100	3	.	.	PUNCT
ct-9922	100	4	lotti	lotti	PROPN
ct-9922	100	5	sn	sn	PROPN
ct-9922	100	6	,	,	PUNCT
ct-9922	100	7	polkoff	polkoff	PROPN
ct-9922	100	8	km	km	PROPN
ct-9922	100	9	,	,	PUNCT
ct-9922	100	10	rubessa	rubessa	NOUN
ct-9922	100	11	m	m	PROPN
ct-9922	100	12	,	,	PUNCT
ct-9922	100	13	et	et	PROPN
ct-9922	100	14	al	al	PROPN
ct-9922	100	15	:	:	PUNCT
ct-9922	100	16	modification	modification	NOUN
ct-9922	100	17	of	of	ADP
ct-9922	100	18	the	the	DET
ct-9922	100	19	genome	genome	NOUN
ct-9922	100	20	of	of	ADP
ct-9922	100	21	domestic	domestic	ADJ
ct-9922	100	22	animals	animal	NOUN
ct-9922	100	23	.	.	PUNCT
ct-9922	101	1	anim	anim	NOUN
ct-9922	101	2	biotechnol	biotechnol	PROPN
ct-9922	101	3	2017;28:198	2017;28:198	PROPN
ct-9922	101	4	-	-	SYM
ct-9922	101	5	210	210	NUM
ct-9922	101	6	.	.	PUNCT
ct-9922	102	1	2	2	X
ct-9922	102	2	.	.	X
ct-9922	102	3	tan	tan	PROPN
ct-9922	102	4	w	w	PROPN
ct-9922	102	5	,	,	PUNCT
ct-9922	102	6	proudfoot	proudfoot	NOUN
ct-9922	102	7	c	c	NOUN
ct-9922	102	8	,	,	PUNCT
ct-9922	102	9	lillico	lillico	NOUN
ct-9922	102	10	sg	sg	PROPN
ct-9922	102	11	,	,	PUNCT
ct-9922	102	12	et	et	PROPN
ct-9922	102	13	al	al	PROPN
ct-9922	102	14	:	:	PUNCT
ct-9922	102	15	gene	gene	NOUN
ct-9922	102	16	targeting	targeting	NOUN
ct-9922	102	17	,	,	PUNCT
ct-9922	102	18	genome	genome	NOUN
ct-9922	102	19	editing	editing	NOUN
ct-9922	102	20	:	:	PUNCT
ct-9922	102	21	from	from	ADP
ct-9922	102	22	dolly	dolly	ADV
ct-9922	102	23	to	to	ADP
ct-9922	102	24	editors	editor	NOUN
ct-9922	102	25	.	.	PUNCT
ct-9922	103	1	transgenic	transgenic	NOUN
ct-9922	103	2	res	re	NOUN
ct-9922	103	3	2016;25:273	2016;25:273	NOUN
ct-9922	103	4	-	-	SYM
ct-9922	103	5	287	287	NUM
ct-9922	103	6	.	.	PUNCT
ct-9922	104	1	3	3	X
ct-9922	104	2	.	.	X
ct-9922	105	1	jaenisch	jaenisch	PROPN
ct-9922	105	2	r	r	NOUN
ct-9922	105	3	:	:	PUNCT
ct-9922	105	4	germ	germ	NOUN
ct-9922	105	5	line	line	NOUN
ct-9922	105	6	integration	integration	NOUN
ct-9922	105	7	and	and	CCONJ
ct-9922	105	8	mendelian	mendelian	ADJ
ct-9922	105	9	transmission	transmission	NOUN
ct-9922	105	10	of	of	ADP
ct-9922	105	11	the	the	DET
ct-9922	105	12	exogenous	exogenous	ADJ
ct-9922	105	13	moloney	moloney	PROPN
ct-9922	105	14	leukemia	leukemia	PROPN
ct-9922	105	15	virus	virus	NOUN
ct-9922	105	16	.	.	PUNCT
ct-9922	106	1	proc	proc	PROPN
ct-9922	106	2	nat	nat	PROPN
ct-9922	106	3	acad	acad	PROPN
ct-9922	106	4	sci	sci	PROPN
ct-9922	106	5	1976;73:1260	1976;73:1260	PROPN
ct-9922	106	6	-	-	SYM
ct-9922	106	7	1264	1264	NUM
ct-9922	106	8	.	.	PUNCT
ct-9922	107	1	4	4	X
ct-9922	107	2	.	.	X
ct-9922	107	3	hofmann	hofmann	PROPN
ct-9922	107	4	a	a	PROPN
ct-9922	107	5	,	,	PUNCT
ct-9922	107	6	kessler	kessler	PROPN
ct-9922	107	7	b	b	PROPN
ct-9922	107	8	,	,	PUNCT
ct-9922	107	9	ewerling	ewerle	VERB
ct-9922	107	10	s	s	PRON
ct-9922	107	11	,	,	PUNCT
ct-9922	107	12	et	et	PROPN
ct-9922	107	13	al	al	PROPN
ct-9922	107	14	:	:	PUNCT
ct-9922	107	15	efficient	efficient	ADJ
ct-9922	107	16	transgenesis	transgenesis	NOUN
ct-9922	107	17	in	in	ADP
ct-9922	107	18	farm	farm	NOUN
ct-9922	107	19	animals	animal	NOUN
ct-9922	107	20	by	by	ADP
ct-9922	107	21	lentiviral	lentiviral	ADJ
ct-9922	107	22	vectors	vector	NOUN
ct-9922	107	23	.	.	PUNCT
ct-9922	108	1	embo	embo	PROPN
ct-9922	108	2	reports	report	VERB
ct-9922	108	3	2003;4:1054	2003;4:1054	PROPN
ct-9922	108	4	-	-	SYM
ct-9922	108	5	1058	1058	NUM
ct-9922	108	6	.	.	PUNCT
ct-9922	109	1	5	5	NUM
ct-9922	109	2	.	.	X
ct-9922	110	1	chan	chan	PROPN
ct-9922	110	2	aw	aw	INTJ
ct-9922	110	3	,	,	PUNCT
ct-9922	110	4	homan	homan	PROPN
ct-9922	110	5	ej	ej	PROPN
ct-9922	110	6	,	,	PUNCT
ct-9922	110	7	ballou	ballou	PROPN
ct-9922	110	8	lu	lu	PROPN
ct-9922	110	9	,	,	PUNCT
ct-9922	110	10	et	et	PROPN
ct-9922	110	11	al	al	PROPN
ct-9922	110	12	:	:	PUNCT
ct-9922	110	13	transgenic	transgenic	NOUN
ct-9922	110	14	cattle	cattle	NOUN
ct-9922	110	15	produced	produce	VERB
ct-9922	110	16	by	by	ADP
ct-9922	110	17	reverse	reverse	NOUN
ct-9922	110	18	-	-	PUNCT
ct-9922	110	19	transcribed	transcribe	VERB
ct-9922	110	20	gene	gene	NOUN
ct-9922	110	21	transfer	transfer	NOUN
ct-9922	110	22	in	in	ADP
ct-9922	110	23	oocytes	oocyte	NOUN
ct-9922	110	24	.	.	PUNCT
ct-9922	111	1	proc	proc	PROPN
ct-9922	111	2	nat	nat	PROPN
ct-9922	111	3	acad	acad	PROPN
ct-9922	111	4	sci	sci	PROPN
ct-9922	111	5	1998;95:14028	1998;95:14028	PROPN
ct-9922	111	6	-	-	PUNCT
ct-9922	111	7	14033	14033	NUM
ct-9922	111	8	.	.	PUNCT
ct-9922	112	1	6	6	NUM
ct-9922	112	2	.	.	X
ct-9922	112	3	gordon	gordon	PROPN
ct-9922	112	4	jw	jw	PROPN
ct-9922	112	5	,	,	PUNCT
ct-9922	112	6	scangos	scangos	PROPN
ct-9922	112	7	ga	ga	PROPN
ct-9922	112	8	,	,	PUNCT
ct-9922	112	9	plotkin	plotkin	PROPN
ct-9922	112	10	dj	dj	PROPN
ct-9922	112	11	,	,	PUNCT
ct-9922	112	12	et	et	PROPN
ct-9922	112	13	al	al	PROPN
ct-9922	112	14	:	:	PUNCT
ct-9922	112	15	genetic	genetic	ADJ
ct-9922	112	16	transformation	transformation	NOUN
ct-9922	112	17	of	of	ADP
ct-9922	112	18	mouse	mouse	NOUN
ct-9922	112	19	embryos	embryo	NOUN
ct-9922	112	20	by	by	ADP
ct-9922	112	21	microinjection	microinjection	NOUN
ct-9922	112	22	of	of	ADP
ct-9922	112	23	purified	purified	ADJ
ct-9922	112	24	dna	dna	NOUN
ct-9922	112	25	.	.	PUNCT
ct-9922	113	1	proc	proc	PROPN
ct-9922	113	2	nat	nat	PROPN
ct-9922	113	3	acad	acad	PROPN
ct-9922	113	4	sci	sci	PROPN
ct-9922	113	5	1980;77:7380	1980;77:7380	PROPN
ct-9922	113	6	-	-	SYM
ct-9922	113	7	7384	7384	NUM
ct-9922	113	8	.	.	PUNCT
ct-9922	114	1	7	7	X
ct-9922	114	2	.	.	X
ct-9922	114	3	hammer	hammer	PROPN
ct-9922	114	4	re	re	PROPN
ct-9922	114	5	,	,	PUNCT
ct-9922	114	6	pursel	pursel	NOUN
ct-9922	114	7	vg	vg	NOUN
ct-9922	114	8	,	,	PUNCT
ct-9922	114	9	rexroad	rexroad	NOUN
ct-9922	114	10	jr	jr	PROPN
ct-9922	114	11	ce	ce	PROPN
ct-9922	114	12	,	,	PUNCT
ct-9922	114	13	et	et	PROPN
ct-9922	114	14	al	al	PROPN
ct-9922	114	15	:	:	PUNCT
ct-9922	114	16	production	production	NOUN
ct-9922	114	17	of	of	ADP
ct-9922	114	18	transgenic	transgenic	NOUN
ct-9922	114	19	rabbits	rabbit	NOUN
ct-9922	114	20	,	,	PUNCT
ct-9922	114	21	sheep	sheep	NOUN
ct-9922	114	22	and	and	CCONJ
ct-9922	114	23	pigs	pig	NOUN
ct-9922	114	24	by	by	ADP
ct-9922	114	25	microinjection	microinjection	NOUN
ct-9922	114	26	.	.	PUNCT
ct-9922	115	1	nature	nature	NOUN
ct-9922	115	2	1985;315:680	1985;315:680	NUM
ct-9922	115	3	.	.	PROPN
ct-9922	115	4	8	8	NUM
ct-9922	115	5	nagashima	nagashima	NOUN
ct-9922	115	6	h	h	NOUN
ct-9922	115	7	,	,	PUNCT
ct-9922	115	8	fujimura	fujimura	PROPN
ct-9922	115	9	t	t	PROPN
ct-9922	115	10	,	,	PUNCT
ct-9922	115	11	takahagi	takahagi	PROPN
ct-9922	115	12	y	y	PROPN
ct-9922	115	13	,	,	PUNCT
ct-9922	115	14	et	et	PROPN
ct-9922	115	15	al	al	PROPN
ct-9922	115	16	:	:	PUNCT
ct-9922	115	17	development	development	NOUN
ct-9922	115	18	of	of	ADP
ct-9922	115	19	efficient	efficient	ADJ
ct-9922	115	20	strategies	strategy	NOUN
ct-9922	115	21	for	for	ADP
ct-9922	115	22	the	the	DET
ct-9922	115	23	production	production	NOUN
ct-9922	115	24	of	of	ADP
ct-9922	115	25	genetically	genetically	ADV
ct-9922	115	26	modified	modify	VERB
ct-9922	115	27	pigs	pig	NOUN
ct-9922	115	28	.	.	PUNCT
ct-9922	116	1	theriogenology	theriogenology	NOUN
ct-9922	116	2	2003;59:95	2003;59:95	NUM
ct-9922	116	3	-	-	SYM
ct-9922	116	4	106	106	NUM
ct-9922	116	5	.	.	PUNCT
ct-9922	116	6	9	9	X
ct-9922	116	7	.	.	X
ct-9922	116	8	uchida	uchida	PROPN
ct-9922	116	9	m	m	PROPN
ct-9922	116	10	,	,	PUNCT
ct-9922	116	11	shimatsu	shimatsu	PROPN
ct-9922	116	12	y	y	NOUN
ct-9922	116	13	,	,	PUNCT
ct-9922	116	14	onoe	onoe	PROPN
ct-9922	116	15	k	k	PROPN
ct-9922	116	16	,	,	PUNCT
ct-9922	116	17	et	et	PROPN
ct-9922	116	18	al	al	PROPN
ct-9922	116	19	:	:	PUNCT
ct-9922	116	20	production	production	NOUN
ct-9922	116	21	of	of	ADP
ct-9922	116	22	transgenic	transgenic	NOUN
ct-9922	116	23	miniature	miniature	ADJ
ct-9922	116	24	pigs	pig	NOUN
ct-9922	116	25	by	by	ADP
ct-9922	116	26	pronuclear	pronuclear	NOUN
ct-9922	116	27	microinjection	microinjection	NOUN
ct-9922	116	28	.	.	PUNCT
ct-9922	117	1	transgenic	transgenic	NOUN
ct-9922	117	2	res	re	NOUN
ct-9922	117	3	2001;10:577	2001;10:577	PROPN
ct-9922	117	4	-	-	NUM
ct-9922	117	5	582	582	NUM
ct-9922	117	6	.	.	NOUN
ct-9922	117	7	10	10	NUM
ct-9922	117	8	.	.	PUNCT
ct-9922	118	1	krimpenfort	krimpenfort	PROPN
ct-9922	118	2	p	p	X
ct-9922	118	3	,	,	PUNCT
ct-9922	118	4	rademakers	rademaker	NOUN
ct-9922	118	5	a	a	PRON
ct-9922	118	6	,	,	PUNCT
ct-9922	118	7	eyestone	eyestone	NOUN
ct-9922	118	8	w	w	NOUN
ct-9922	118	9	,	,	PUNCT
ct-9922	118	10	et	et	PROPN
ct-9922	118	11	al	al	PROPN
ct-9922	118	12	:	:	PUNCT
ct-9922	118	13	generation	generation	NOUN
ct-9922	118	14	of	of	ADP
ct-9922	118	15	transgenic	transgenic	NOUN
ct-9922	118	16	dairy	dairy	NOUN
ct-9922	118	17	cattle	cattle	NOUN
ct-9922	118	18	using	use	VERB
ct-9922	118	19	'	'	PUNCT
ct-9922	118	20	in	in	ADP
ct-9922	118	21	vitro	vitro	X
ct-9922	118	22	'	'	PUNCT
ct-9922	118	23	embryo	embryo	NOUN
ct-9922	118	24	production	production	NOUN
ct-9922	118	25	.	.	PUNCT
ct-9922	119	1	bio	bio	PROPN
ct-9922	119	2	/	/	SYM
ct-9922	119	3	technology	technology	NOUN
ct-9922	119	4	1991;9:844	1991;9:844	NUM
ct-9922	119	5	-	-	SYM
ct-9922	119	6	847	847	NUM
ct-9922	119	7	.	.	PUNCT
ct-9922	119	8	11	11	NUM
ct-9922	119	9	.	.	PUNCT
ct-9922	120	1	yokoyama	yokoyama	PROPN
ct-9922	120	2	t	t	PROPN
ct-9922	120	3	,	,	PUNCT
ct-9922	120	4	copeland	copeland	PROPN
ct-9922	120	5	ng	ng	PROPN
ct-9922	120	6	,	,	PUNCT
ct-9922	120	7	jenkins	jenkins	PROPN
ct-9922	120	8	na	na	PROPN
ct-9922	120	9	,	,	PUNCT
ct-9922	120	10	et	et	PROPN
ct-9922	120	11	al	al	PROPN
ct-9922	120	12	:	:	PUNCT
ct-9922	120	13	reversal	reversal	NOUN
ct-9922	120	14	of	of	ADP
ct-9922	120	15	left	left	ADJ
ct-9922	120	16	-	-	PUNCT
ct-9922	120	17	right	right	NOUN
ct-9922	120	18	asymmetry	asymmetry	NOUN
ct-9922	120	19	:	:	PUNCT
ct-9922	120	20	a	a	DET
ct-9922	120	21	situs	situs	PROPN
ct-9922	120	22	inversus	inversus	NOUN
ct-9922	120	23	mutation	mutation	NOUN
ct-9922	120	24	.	.	PUNCT
ct-9922	121	1	science	science	NOUN
ct-9922	121	2	.	.	PUNCT
ct-9922	122	1	1993;260:679	1993;260:679	NUM
ct-9922	122	2	-	-	SYM
ct-9922	122	3	682	682	NUM
ct-9922	122	4	.	.	PUNCT
ct-9922	123	1	12	12	NUM
ct-9922	123	2	.	.	PUNCT
ct-9922	124	1	doetschman	doetschman	PROPN
ct-9922	124	2	t	t	PROPN
ct-9922	124	3	,	,	PUNCT
ct-9922	124	4	gregg	gregg	PROPN
ct-9922	124	5	rg	rg	PROPN
ct-9922	124	6	,	,	PUNCT
ct-9922	124	7	maeda	maeda	PROPN
ct-9922	124	8	n	n	CCONJ
ct-9922	124	9	,	,	PUNCT
ct-9922	124	10	et	et	PROPN
ct-9922	124	11	al	al	PROPN
ct-9922	124	12	:	:	PUNCT
ct-9922	124	13	targetted	targetted	ADJ
ct-9922	124	14	correction	correction	NOUN
ct-9922	124	15	of	of	ADP
ct-9922	124	16	a	a	DET
ct-9922	124	17	mutant	mutant	ADJ
ct-9922	124	18	hprt	hprt	NOUN
ct-9922	124	19	gene	gene	NOUN
ct-9922	124	20	in	in	ADP
ct-9922	124	21	mouse	mouse	NOUN
ct-9922	124	22	embryonic	embryonic	ADJ
ct-9922	124	23	stem	stem	NOUN
ct-9922	124	24	cells	cell	NOUN
ct-9922	124	25	.	.	PUNCT
ct-9922	125	1	nature	nature	NOUN
ct-9922	125	2	.	.	PUNCT
ct-9922	126	1	1987;330:576	1987;330:576	NUM
ct-9922	126	2	-	-	SYM
ct-9922	126	3	578	578	NUM
ct-9922	126	4	.	.	NOUN
ct-9922	127	1	13	13	NUM
ct-9922	127	2	.	.	PUNCT
ct-9922	127	3	safinia	safinia	PROPN
ct-9922	127	4	n	n	PROPN
ct-9922	127	5	,	,	PUNCT
ct-9922	127	6	becker	becker	PROPN
ct-9922	127	7	pd	pd	PROPN
ct-9922	127	8	,	,	PUNCT
ct-9922	127	9	vaikunthanathan	vaikunthanathan	ADP
ct-9922	127	10	t	t	PROPN
ct-9922	127	11	,	,	PUNCT
ct-9922	127	12	et	et	PROPN
ct-9922	127	13	al	al	PROPN
ct-9922	127	14	:	:	PUNCT
ct-9922	127	15	humanized	humanize	VERB
ct-9922	127	16	mice	mouse	NOUN
ct-9922	127	17	as	as	ADP
ct-9922	127	18	preclinical	preclinical	ADJ
ct-9922	127	19	models	model	NOUN
ct-9922	127	20	in	in	ADP
ct-9922	127	21	transplantation	transplantation	NOUN
ct-9922	127	22	.	.	PUNCT
ct-9922	128	1	methods	method	NOUN
ct-9922	128	2	mol	mol	ADP
ct-9922	128	3	biol	biol	PROPN
ct-9922	128	4	2016;1371:177	2016;1371:177	PROPN
ct-9922	128	5	-	-	NOUN
ct-9922	128	6	196	196	NUM
ct-9922	128	7	.	.	PUNCT
ct-9922	128	8	14	14	NUM
ct-9922	128	9	.	.	PUNCT
ct-9922	129	1	bunner	bunner	PROPN
ct-9922	129	2	ae	ae	PROPN
ct-9922	129	3	,	,	PUNCT
ct-9922	129	4	chandrasekera	chandrasekera	NOUN
ct-9922	129	5	pc	pc	PROPN
ct-9922	129	6	,	,	PUNCT
ct-9922	129	7	barnard	barnard	PROPN
ct-9922	129	8	nd	nd	PRON
ct-9922	129	9	:	:	PUNCT
ct-9922	129	10	knockout	knockout	NOUN
ct-9922	129	11	mouse	mouse	NOUN
ct-9922	129	12	models	model	NOUN
ct-9922	129	13	of	of	ADP
ct-9922	129	14	insulin	insulin	NOUN
ct-9922	129	15	signaling	signaling	NOUN
ct-9922	129	16	:	:	PUNCT
ct-9922	129	17	relevance	relevance	NOUN
ct-9922	129	18	past	past	NOUN
ct-9922	129	19	and	and	CCONJ
ct-9922	129	20	future	future	NOUN
ct-9922	129	21	.	.	PUNCT
ct-9922	130	1	world	world	PROPN
ct-9922	130	2	j	j	PROPN
ct-9922	130	3	diabetes	diabetes	PROPN
ct-9922	130	4	2014;5:146	2014;5:146	NUM
ct-9922	130	5	-	-	SYM
ct-9922	130	6	159	159	NUM
ct-9922	130	7	.	.	PUNCT
ct-9922	130	8	15	15	NUM
ct-9922	130	9	.	.	PUNCT
ct-9922	131	1	melton	melton	PROPN
ct-9922	131	2	dw	dw	PROPN
ct-9922	131	3	:	:	PUNCT
ct-9922	131	4	gene	gene	NOUN
ct-9922	131	5	targeting	target	VERB
ct-9922	131	6	in	in	ADP
ct-9922	131	7	the	the	DET
ct-9922	131	8	mouse	mouse	NOUN
ct-9922	131	9	.	.	PUNCT
ct-9922	132	1	bioessays	bioessay	NOUN
ct-9922	132	2	1994;16:633	1994;16:633	NOUN
ct-9922	132	3	-	-	SYM
ct-9922	132	4	638	638	NUM
ct-9922	132	5	.	.	PUNCT
ct-9922	133	1	clinical	clinical	ADJ
ct-9922	133	2	theriogenology	theriogenology	NOUN
ct-9922	133	3	•	•	NOUN
ct-9922	133	4	volume	volume	NOUN
ct-9922	133	5	10	10	NUM
ct-9922	133	6	,	,	PUNCT
ct-9922	133	7	number	number	NOUN
ct-9922	133	8	3	3	NUM
ct-9922	133	9	•	•	NUM
ct-9922	133	10	september	september	PROPN
ct-9922	133	11	2018243	2018243	NUM
ct-9922	133	12	16	16	NUM
ct-9922	133	13	.	.	PUNCT
ct-9922	134	1	prather	prather	PROPN
ct-9922	134	2	rs	rs	PROPN
ct-9922	134	3	,	,	PUNCT
ct-9922	134	4	barnes	barnes	PROPN
ct-9922	134	5	fl	fl	PROPN
ct-9922	134	6	,	,	PUNCT
ct-9922	134	7	sims	sim	NOUN
ct-9922	134	8	mm	mm	PROPN
ct-9922	134	9	,	,	PUNCT
ct-9922	134	10	et	et	PROPN
ct-9922	134	11	al	al	PROPN
ct-9922	134	12	:	:	PUNCT
ct-9922	134	13	nuclear	nuclear	ADJ
ct-9922	134	14	transplantation	transplantation	NOUN
ct-9922	134	15	in	in	ADP
ct-9922	134	16	the	the	DET
ct-9922	134	17	bovine	bovine	ADJ
ct-9922	134	18	embryo	embryo	NOUN
ct-9922	134	19	:	:	PUNCT
ct-9922	134	20	assessment	assessment	NOUN
ct-9922	134	21	of	of	ADP
ct-9922	134	22	donor	donor	NOUN
ct-9922	134	23	nuclei	nucleus	NOUN
ct-9922	134	24	and	and	CCONJ
ct-9922	134	25	recipient	recipient	NOUN
ct-9922	134	26	oocyte	oocyte	PROPN
ct-9922	134	27	biol	biol	PROPN
ct-9922	134	28	reprod	reprod	NOUN
ct-9922	134	29	1987;37:859	1987;37:859	PROPN
ct-9922	134	30	-	-	NOUN
ct-9922	134	31	866	866	NUM
ct-9922	134	32	.	.	PUNCT
ct-9922	135	1	17	17	NUM
ct-9922	135	2	.	.	PUNCT
ct-9922	136	1	sims	sim	NOUN
ct-9922	136	2	m	m	PROPN
ct-9922	136	3	,	,	PUNCT
ct-9922	136	4	first	first	ADJ
ct-9922	136	5	n	n	CCONJ
ct-9922	136	6	:	:	PUNCT
ct-9922	136	7	production	production	NOUN
ct-9922	136	8	of	of	ADP
ct-9922	136	9	calves	calf	NOUN
ct-9922	136	10	by	by	ADP
ct-9922	136	11	transfer	transfer	NOUN
ct-9922	136	12	of	of	ADP
ct-9922	136	13	nuclei	nucleus	NOUN
ct-9922	136	14	from	from	ADP
ct-9922	136	15	cultured	cultured	ADJ
ct-9922	136	16	inner	inner	ADJ
ct-9922	136	17	cell	cell	NOUN
ct-9922	136	18	mass	mass	NOUN
ct-9922	136	19	cells	cell	NOUN
ct-9922	136	20	.	.	PUNCT
ct-9922	137	1	proc	proc	NOUN
ct-9922	137	2	nat	nat	PROPN
ct-9922	137	3	acad	acad	PROPN
ct-9922	137	4	sci	sci	PROPN
ct-9922	137	5	1994;91:6143	1994;91:6143	PROPN
ct-9922	137	6	-	-	PUNCT
ct-9922	137	7	6147	6147	NUM
ct-9922	137	8	.	.	PUNCT
ct-9922	138	1	18	18	NUM
ct-9922	138	2	.	.	X
ct-9922	139	1	prather	prather	PROPN
ct-9922	139	2	rs	rs	PROPN
ct-9922	139	3	,	,	PUNCT
ct-9922	139	4	sims	sim	NOUN
ct-9922	139	5	mm	mm	PROPN
ct-9922	139	6	,	,	PUNCT
ct-9922	139	7	first	first	ADJ
ct-9922	139	8	nl	nl	PROPN
ct-9922	139	9	:	:	PUNCT
ct-9922	139	10	nuclear	nuclear	ADJ
ct-9922	139	11	transplantation	transplantation	NOUN
ct-9922	139	12	in	in	ADP
ct-9922	139	13	early	early	ADJ
ct-9922	139	14	pig	pig	NOUN
ct-9922	139	15	embryos	embryo	NOUN
ct-9922	139	16	.	.	PUNCT
ct-9922	140	1	biol	biol	PROPN
ct-9922	140	2	reprod	reprod	PROPN
ct-9922	140	3	1989;41:414	1989;41:414	X
ct-9922	140	4	-	-	SYM
ct-9922	140	5	418	418	NUM
ct-9922	140	6	.	.	PUNCT
ct-9922	140	7	19	19	NUM
ct-9922	140	8	.	.	PUNCT
ct-9922	141	1	campbell	campbell	PROPN
ct-9922	141	2	kh	kh	PROPN
ct-9922	141	3	,	,	PUNCT
ct-9922	141	4	mcwhir	mcwhir	PROPN
ct-9922	141	5	j	j	PROPN
ct-9922	141	6	,	,	PUNCT
ct-9922	141	7	ritchie	ritchie	PROPN
ct-9922	141	8	wa	wa	PROPN
ct-9922	141	9	,	,	PUNCT
ct-9922	141	10	et	et	PROPN
ct-9922	141	11	al	al	PROPN
ct-9922	141	12	:	:	PUNCT
ct-9922	141	13	sheep	sheep	NOUN
ct-9922	141	14	cloned	clone	VERB
ct-9922	141	15	by	by	ADP
ct-9922	141	16	nuclear	nuclear	ADJ
ct-9922	141	17	transfer	transfer	NOUN
ct-9922	141	18	from	from	ADP
ct-9922	141	19	a	a	DET
ct-9922	141	20	cultured	cultured	ADJ
ct-9922	141	21	cell	cell	NOUN
ct-9922	141	22	line	line	NOUN
ct-9922	141	23	.	.	PUNCT
ct-9922	142	1	nature	nature	NOUN
ct-9922	142	2	1996;380:64	1996;380:64	NUM
ct-9922	142	3	.	.	PUNCT
ct-9922	143	1	20	20	NUM
ct-9922	143	2	.	.	X
ct-9922	143	3	wilmut	wilmut	PROPN
ct-9922	143	4	i	i	PROPN
ct-9922	143	5	,	,	PUNCT
ct-9922	143	6	schnieke	schnieke	PROPN
ct-9922	143	7	ae	ae	PROPN
ct-9922	143	8	,	,	PUNCT
ct-9922	143	9	mcwhir	mcwhir	PROPN
ct-9922	143	10	j	j	PROPN
ct-9922	143	11	,	,	PUNCT
ct-9922	143	12	et	et	PROPN
ct-9922	143	13	al	al	PROPN
ct-9922	143	14	:	:	PUNCT
ct-9922	144	1	viable	viable	ADJ
ct-9922	144	2	offspring	offspring	NOUN
ct-9922	144	3	derived	derive	VERB
ct-9922	144	4	from	from	ADP
ct-9922	144	5	fetal	fetal	ADJ
ct-9922	144	6	and	and	CCONJ
ct-9922	144	7	adult	adult	NOUN
ct-9922	144	8	mammalian	mammalian	ADJ
ct-9922	144	9	cells	cell	NOUN
ct-9922	144	10	.	.	PUNCT
ct-9922	145	1	nature	nature	NOUN
ct-9922	145	2	1997;385:810	1997;385:810	NUM
ct-9922	145	3	.	.	PROPN
ct-9922	145	4	21	21	NUM
ct-9922	145	5	.	.	PUNCT
ct-9922	145	6	schnieke	schnieke	PROPN
ct-9922	145	7	ae	ae	PROPN
ct-9922	145	8	,	,	PUNCT
ct-9922	145	9	kind	kind	PROPN
ct-9922	145	10	aj	aj	PROPN
ct-9922	145	11	,	,	PUNCT
ct-9922	145	12	ritchie	ritchie	PROPN
ct-9922	145	13	wa	wa	PROPN
ct-9922	145	14	,	,	PUNCT
ct-9922	145	15	et	et	PROPN
ct-9922	145	16	al	al	PROPN
ct-9922	145	17	:	:	PUNCT
ct-9922	145	18	human	human	ADJ
ct-9922	145	19	factor	factor	NOUN
ct-9922	145	20	ix	ix	ADP
ct-9922	145	21	transgenic	transgenic	NOUN
ct-9922	145	22	sheep	sheep	NOUN
ct-9922	145	23	produced	produce	VERB
ct-9922	145	24	by	by	ADP
ct-9922	145	25	transfer	transfer	NOUN
ct-9922	145	26	of	of	ADP
ct-9922	145	27	nuclei	nucleus	NOUN
ct-9922	145	28	from	from	ADP
ct-9922	145	29	transfected	transfecte	VERB
ct-9922	145	30	fetal	fetal	ADJ
ct-9922	145	31	fibroblasts	fibroblast	NOUN
ct-9922	145	32	.	.	PUNCT
ct-9922	146	1	science	science	NOUN
ct-9922	146	2	1997;278:2130	1997;278:2130	NUM
ct-9922	146	3	-	-	SYM
ct-9922	146	4	2133	2133	NUM
ct-9922	146	5	.	.	PUNCT
ct-9922	147	1	22	22	NUM
ct-9922	147	2	.	.	PUNCT
ct-9922	147	3	denning	den	VERB
ct-9922	147	4	c	c	NOUN
ct-9922	147	5	,	,	PUNCT
ct-9922	147	6	burl	burl	VERB
ct-9922	147	7	s	s	PROPN
ct-9922	147	8	,	,	PUNCT
ct-9922	147	9	ainslie	ainslie	PROPN
ct-9922	147	10	a	a	PROPN
ct-9922	147	11	,	,	PUNCT
ct-9922	147	12	et	et	PROPN
ct-9922	147	13	al	al	PROPN
ct-9922	147	14	:	:	PUNCT
ct-9922	147	15	deletion	deletion	NOUN
ct-9922	147	16	of	of	ADP
ct-9922	147	17	the	the	DET
ct-9922	147	18	α	α	NOUN
ct-9922	147	19	(	(	PUNCT
ct-9922	147	20	1	1	NUM
ct-9922	147	21	,	,	PUNCT
ct-9922	147	22	3	3	X
ct-9922	147	23	)	)	PUNCT
ct-9922	147	24	galactosyl	galactosyl	ADJ
ct-9922	147	25	transferase	transferase	NOUN
ct-9922	147	26	(	(	PUNCT
ct-9922	147	27	ggta1	ggta1	NOUN
ct-9922	147	28	)	)	PUNCT
ct-9922	147	29	gene	gene	NOUN
ct-9922	147	30	and	and	CCONJ
ct-9922	147	31	the	the	DET
ct-9922	147	32	prion	prion	NOUN
ct-9922	147	33	protein	protein	NOUN
ct-9922	147	34	(	(	PUNCT
ct-9922	147	35	prp	prp	NOUN
ct-9922	147	36	)	)	PUNCT
ct-9922	147	37	gene	gene	NOUN
ct-9922	147	38	in	in	ADP
ct-9922	147	39	sheep	sheep	NOUN
ct-9922	147	40	.	.	PUNCT
ct-9922	148	1	nat	nat	PROPN
ct-9922	148	2	biotechnol	biotechnol	PROPN
ct-9922	148	3	2001;19:559	2001;19:559	NUM
ct-9922	148	4	.	.	PROPN
ct-9922	148	5	23	23	NUM
ct-9922	148	6	.	.	PUNCT
ct-9922	149	1	lai	lai	PROPN
ct-9922	149	2	l	l	PROPN
ct-9922	149	3	,	,	PUNCT
ct-9922	149	4	kolber	kolber	PROPN
ct-9922	149	5	-	-	PUNCT
ct-9922	149	6	simonds	simonds	PROPN
ct-9922	149	7	d	d	PROPN
ct-9922	149	8	,	,	PUNCT
ct-9922	149	9	park	park	NOUN
ct-9922	149	10	kw	kw	PROPN
ct-9922	149	11	,	,	PUNCT
ct-9922	149	12	et	et	PROPN
ct-9922	149	13	al	al	PROPN
ct-9922	149	14	:	:	PUNCT
ct-9922	149	15	production	production	NOUN
ct-9922	149	16	of	of	ADP
ct-9922	149	17	alpha-1,3	alpha-1,3	NOUN
ct-9922	149	18	-	-	PUNCT
ct-9922	149	19	galactosyltransferase	galactosyltransferase	NOUN
ct-9922	149	20	knockout	knockout	NOUN
ct-9922	149	21	pigs	pig	NOUN
ct-9922	149	22	by	by	ADP
ct-9922	149	23	nuclear	nuclear	ADJ
ct-9922	149	24	transfer	transfer	NOUN
ct-9922	149	25	cloning	cloning	NOUN
ct-9922	149	26	.	.	PUNCT
ct-9922	150	1	science	science	NOUN
ct-9922	150	2	2002;295:1089	2002;295:1089	NUM
ct-9922	150	3	-	-	SYM
ct-9922	150	4	1092	1092	NUM
ct-9922	150	5	.	.	PUNCT
ct-9922	151	1	24	24	NUM
ct-9922	151	2	.	.	PUNCT
ct-9922	152	1	richt	richt	PROPN
ct-9922	152	2	ja	ja	PROPN
ct-9922	152	3	,	,	PUNCT
ct-9922	152	4	kasinathan	kasinathan	PROPN
ct-9922	152	5	p	p	PROPN
ct-9922	152	6	,	,	PUNCT
ct-9922	152	7	hamir	hamir	X
ct-9922	152	8	an	an	PROPN
ct-9922	152	9	,	,	PUNCT
ct-9922	152	10	et	et	PROPN
ct-9922	152	11	al	al	PROPN
ct-9922	152	12	:	:	PUNCT
ct-9922	152	13	production	production	NOUN
ct-9922	152	14	of	of	ADP
ct-9922	152	15	cattle	cattle	NOUN
ct-9922	152	16	lacking	lack	VERB
ct-9922	152	17	prion	prion	NOUN
ct-9922	152	18	protein	protein	NOUN
ct-9922	152	19	.	.	PUNCT
ct-9922	153	1	na	na	ADP
ct-9922	153	2	biotechnol	biotechnol	PROPN
ct-9922	153	3	2007;25:132	2007;25:132	PROPN
ct-9922	153	4	-	-	SYM
ct-9922	153	5	138	138	NUM
ct-9922	153	6	.	.	PUNCT
ct-9922	154	1	25	25	NUM
ct-9922	154	2	.	.	PUNCT
ct-9922	155	1	li	li	PROPN
ct-9922	155	2	p	p	PROPN
ct-9922	155	3	,	,	PUNCT
ct-9922	155	4	estrada	estrada	PROPN
ct-9922	155	5	jl	jl	PROPN
ct-9922	155	6	,	,	PUNCT
ct-9922	155	7	burlak	burlak	ADJ
ct-9922	155	8	c	c	NOUN
ct-9922	155	9	,	,	PUNCT
ct-9922	155	10	et	et	PROPN
ct-9922	155	11	al	al	PROPN
ct-9922	155	12	:	:	PUNCT
ct-9922	155	13	efficient	efficient	ADJ
ct-9922	155	14	generation	generation	NOUN
ct-9922	155	15	of	of	ADP
ct-9922	155	16	genetically	genetically	ADV
ct-9922	155	17	distinct	distinct	ADJ
ct-9922	155	18	pigs	pig	NOUN
ct-9922	155	19	in	in	ADP
ct-9922	155	20	a	a	DET
ct-9922	155	21	single	single	ADJ
ct-9922	155	22	pregnancy	pregnancy	NOUN
ct-9922	155	23	using	use	VERB
ct-9922	155	24	multiplexed	multiplexed	ADJ
ct-9922	155	25	single	single	ADJ
ct-9922	155	26	-	-	PUNCT
ct-9922	155	27	guide	guide	NOUN
ct-9922	155	28	rna	rna	NOUN
ct-9922	155	29	and	and	CCONJ
ct-9922	155	30	carbohydrate	carbohydrate	NOUN
ct-9922	155	31	selection	selection	NOUN
ct-9922	155	32	.	.	PUNCT
ct-9922	156	1	xenotransplantation	xenotransplantation	NOUN
ct-9922	156	2	2015:22:20	2015:22:20	NUM
ct-9922	156	3	-	-	SYM
ct-9922	156	4	31	31	NUM
ct-9922	156	5	.	.	PUNCT
ct-9922	156	6	26	26	NUM
ct-9922	156	7	.	.	PUNCT
ct-9922	157	1	hauschild	hauschild	PROPN
ct-9922	157	2	j	j	PROPN
ct-9922	157	3	,	,	PUNCT
ct-9922	157	4	petersen	petersen	PROPN
ct-9922	157	5	b	b	PROPN
ct-9922	157	6	,	,	PUNCT
ct-9922	157	7	santiago	santiago	PROPN
ct-9922	157	8	y	y	PROPN
ct-9922	157	9	,	,	PUNCT
ct-9922	157	10	et	et	PROPN
ct-9922	157	11	al	al	PROPN
ct-9922	157	12	:	:	PUNCT
ct-9922	157	13	efficient	efficient	ADJ
ct-9922	157	14	generation	generation	NOUN
ct-9922	157	15	of	of	ADP
ct-9922	157	16	a	a	DET
ct-9922	157	17	biallelic	biallelic	ADJ
ct-9922	157	18	knockout	knockout	NOUN
ct-9922	157	19	in	in	ADP
ct-9922	157	20	pigs	pig	NOUN
ct-9922	157	21	using	use	VERB
ct-9922	157	22	zinc	zinc	NOUN
ct-9922	157	23	-	-	PUNCT
ct-9922	157	24	finger	finger	NOUN
ct-9922	157	25	nucleases	nuclease	NOUN
ct-9922	157	26	.	.	PUNCT
ct-9922	158	1	proc	proc	NOUN
ct-9922	158	2	nat	nat	PROPN
ct-9922	158	3	acad	acad	PROPN
ct-9922	158	4	sci	sci	PROPN
ct-9922	158	5	2011;108:12013	2011;108:12013	NUM
ct-9922	158	6	-	-	SYM
ct-9922	158	7	12017	12017	NUM
ct-9922	158	8	.	.	PUNCT
ct-9922	159	1	27	27	NUM
ct-9922	159	2	.	.	PUNCT
ct-9922	160	1	carlson	carlson	PROPN
ct-9922	160	2	df	df	PROPN
ct-9922	160	3	,	,	PUNCT
ct-9922	160	4	tan	tan	PROPN
ct-9922	160	5	w	w	PROPN
ct-9922	160	6	,	,	PUNCT
ct-9922	160	7	lillico	lillico	NOUN
ct-9922	160	8	sg	sg	PROPN
ct-9922	160	9	,	,	PUNCT
ct-9922	160	10	et	et	PROPN
ct-9922	160	11	al	al	PROPN
ct-9922	160	12	:	:	PUNCT
ct-9922	160	13	efficient	efficient	ADJ
ct-9922	160	14	talen	talen	NOUN
ct-9922	160	15	-	-	PUNCT
ct-9922	160	16	mediated	mediate	VERB
ct-9922	160	17	gene	gene	NOUN
ct-9922	160	18	knockout	knockout	NOUN
ct-9922	160	19	in	in	ADP
ct-9922	160	20	livestock	livestock	NOUN
ct-9922	160	21	.	.	PUNCT
ct-9922	161	1	proc	proc	NOUN
ct-9922	161	2	nat	nat	PROPN
ct-9922	161	3	acad	acad	PROPN
ct-9922	161	4	sci	sci	PROPN
ct-9922	161	5	2012;109:17382	2012;109:17382	NUM
ct-9922	161	6	-	-	SYM
ct-9922	161	7	17387	17387	NUM
ct-9922	161	8	.	.	PUNCT
ct-9922	162	1	28	28	NUM
ct-9922	162	2	.	.	PUNCT
ct-9922	163	1	lillico	lillico	PROPN
ct-9922	163	2	sg	sg	PROPN
ct-9922	163	3	,	,	PUNCT
ct-9922	163	4	proudfoot	proudfoot	PROPN
ct-9922	163	5	c	c	NOUN
ct-9922	163	6	,	,	PUNCT
ct-9922	163	7	carlson	carlson	PROPN
ct-9922	163	8	df	df	PROPN
ct-9922	163	9	,	,	PUNCT
ct-9922	163	10	et	et	PROPN
ct-9922	163	11	al	al	PROPN
ct-9922	163	12	:	:	PUNCT
ct-9922	163	13	live	live	VERB
ct-9922	163	14	pigs	pig	NOUN
ct-9922	163	15	produced	produce	VERB
ct-9922	163	16	from	from	ADP
ct-9922	163	17	genome	genome	NOUN
ct-9922	163	18	edited	edit	VERB
ct-9922	163	19	zygotes	zygote	NOUN
ct-9922	163	20	.	.	PUNCT
ct-9922	164	1	sci	sci	PROPN
ct-9922	164	2	rep	rep	PROPN
ct-9922	164	3	2013;3:2847	2013;3:2847	PROPN
ct-9922	164	4	.	.	PUNCT
ct-9922	165	1	29	29	NUM
ct-9922	165	2	.	.	PUNCT
ct-9922	166	1	zhang	zhang	PROPN
ct-9922	166	2	f	f	PROPN
ct-9922	166	3	,	,	PUNCT
ct-9922	166	4	wen	wen	PROPN
ct-9922	166	5	y	y	PROPN
ct-9922	166	6	,	,	PUNCT
ct-9922	166	7	guo	guo	PROPN
ct-9922	166	8	x	x	X
ct-9922	166	9	:	:	PUNCT
ct-9922	166	10	crispr	crispr	ADJ
ct-9922	166	11	/	/	SYM
ct-9922	166	12	cas9	cas9	NOUN
ct-9922	166	13	for	for	ADP
ct-9922	166	14	genome	genome	NOUN
ct-9922	166	15	editing	editing	NOUN
ct-9922	166	16	:	:	PUNCT
ct-9922	166	17	progress	progress	NOUN
ct-9922	166	18	,	,	PUNCT
ct-9922	166	19	implications	implication	NOUN
ct-9922	166	20	and	and	CCONJ
ct-9922	166	21	challenges	challenge	NOUN
ct-9922	166	22	.	.	PUNCT
ct-9922	167	1	hum	hum	PROPN
ct-9922	167	2	mol	mol	ADP
ct-9922	167	3	genet	genet	PROPN
ct-9922	167	4	2014;23	2014;23	NUM
ct-9922	167	5	:	:	PUNCT
ct-9922	167	6	r40	r40	NOUN
ct-9922	167	7	-	-	PUNCT
ct-9922	167	8	r46	r46	NOUN
ct-9922	167	9	.	.	PUNCT
ct-9922	168	1	30	30	NUM
ct-9922	168	2	.	.	PUNCT
ct-9922	169	1	miller	miller	PROPN
ct-9922	169	2	j	j	PROPN
ct-9922	169	3	,	,	PUNCT
ct-9922	169	4	mclachlan	mclachlan	PROPN
ct-9922	169	5	a	a	PROPN
ct-9922	169	6	,	,	PUNCT
ct-9922	169	7	klug	klug	PROPN
ct-9922	169	8	a	a	PRON
ct-9922	169	9	:	:	PUNCT
ct-9922	169	10	repetitive	repetitive	ADJ
ct-9922	169	11	zinc	zinc	NOUN
ct-9922	169	12	-	-	PUNCT
ct-9922	169	13	binding	bind	VERB
ct-9922	169	14	domains	domain	NOUN
ct-9922	169	15	in	in	ADP
ct-9922	169	16	the	the	DET
ct-9922	169	17	protein	protein	NOUN
ct-9922	169	18	transcription	transcription	NOUN
ct-9922	169	19	factor	factor	NOUN
ct-9922	169	20	iiia	iiia	NOUN
ct-9922	169	21	from	from	ADP
ct-9922	169	22	xenopus	xenopus	PROPN
ct-9922	169	23	oocytes	oocytes	PROPN
ct-9922	169	24	.	.	PUNCT
ct-9922	170	1	embo	embo	PROPN
ct-9922	170	2	j	j	PROPN
ct-9922	170	3	1985;4:1609	1985;4:1609	PROPN
ct-9922	170	4	-	-	PUNCT
ct-9922	170	5	1614	1614	NUM
ct-9922	170	6	.	.	PUNCT
ct-9922	171	1	31	31	NUM
ct-9922	171	2	.	.	PUNCT
ct-9922	171	3	urnov	urnov	PROPN
ct-9922	171	4	fd	fd	PROPN
ct-9922	171	5	,	,	PUNCT
ct-9922	171	6	miller	miller	PROPN
ct-9922	171	7	jc	jc	PROPN
ct-9922	171	8	,	,	PUNCT
ct-9922	171	9	lee	lee	PROPN
ct-9922	171	10	y	y	PROPN
ct-9922	171	11	-	-	PUNCT
ct-9922	171	12	l	l	PROPN
ct-9922	171	13	,	,	PUNCT
ct-9922	171	14	et	et	PROPN
ct-9922	171	15	al	al	PROPN
ct-9922	171	16	:	:	PUNCT
ct-9922	171	17	highly	highly	ADV
ct-9922	171	18	efficient	efficient	ADJ
ct-9922	171	19	endogenous	endogenous	ADJ
ct-9922	171	20	human	human	ADJ
ct-9922	171	21	gene	gene	NOUN
ct-9922	171	22	correction	correction	NOUN
ct-9922	171	23	using	use	VERB
ct-9922	171	24	designed	design	VERB
ct-9922	171	25	zinc	zinc	NOUN
ct-9922	171	26	-	-	PUNCT
ct-9922	171	27	finger	finger	NOUN
ct-9922	171	28	nucleases	nuclease	NOUN
ct-9922	171	29	.	.	PUNCT
ct-9922	172	1	nature	nature	NOUN
ct-9922	172	2	2005;435:646	2005;435:646	NUM
ct-9922	172	3	.	.	PUNCT
ct-9922	172	4	32	32	NUM
ct-9922	172	5	.	.	PUNCT
ct-9922	173	1	whyte	whyte	PROPN
ct-9922	173	2	jj	jj	PROPN
ct-9922	173	3	,	,	PUNCT
ct-9922	173	4	prather	prather	NOUN
ct-9922	173	5	rs	rs	NOUN
ct-9922	173	6	:	:	PUNCT
ct-9922	173	7	genetic	genetic	ADJ
ct-9922	173	8	modifications	modification	NOUN
ct-9922	173	9	of	of	ADP
ct-9922	173	10	pigs	pig	NOUN
ct-9922	173	11	for	for	ADP
ct-9922	173	12	medicine	medicine	NOUN
ct-9922	173	13	and	and	CCONJ
ct-9922	173	14	agriculture	agriculture	NOUN
ct-9922	173	15	.	.	PUNCT
ct-9922	174	1	mol	mol	PROPN
ct-9922	174	2	reprod	reprod	PROPN
ct-9922	174	3	dev	dev	PROPN
ct-9922	174	4	2011;78:879	2011;78:879	PROPN
ct-9922	174	5	-	-	PUNCT
ct-9922	174	6	891	891	NUM
ct-9922	174	7	.	.	PUNCT
ct-9922	175	1	33	33	NUM
ct-9922	175	2	.	.	PUNCT
ct-9922	176	1	yang	yang	PROPN
ct-9922	176	2	d	d	PROPN
ct-9922	176	3	,	,	PUNCT
ct-9922	176	4	yang	yang	PROPN
ct-9922	176	5	h	h	PROPN
ct-9922	176	6	,	,	PUNCT
ct-9922	176	7	li	li	PROPN
ct-9922	176	8	w	w	PROPN
ct-9922	176	9	,	,	PUNCT
ct-9922	176	10	et	et	PROPN
ct-9922	176	11	al	al	PROPN
ct-9922	176	12	:	:	PUNCT
ct-9922	176	13	generation	generation	NOUN
ct-9922	176	14	of	of	ADP
ct-9922	176	15	ppargamma	ppargamma	PROPN
ct-9922	176	16	mono	mono	PROPN
ct-9922	176	17	-	-	PUNCT
ct-9922	176	18	allelic	allelic	ADJ
ct-9922	176	19	knockout	knockout	NOUN
ct-9922	176	20	pigs	pig	NOUN
ct-9922	176	21	via	via	ADP
ct-9922	176	22	zinc	zinc	NOUN
ct-9922	176	23	-	-	PUNCT
ct-9922	176	24	finger	finger	NOUN
ct-9922	176	25	nucleases	nuclease	NOUN
ct-9922	176	26	and	and	CCONJ
ct-9922	176	27	nuclear	nuclear	ADJ
ct-9922	176	28	transfer	transfer	NOUN
ct-9922	176	29	cloning	cloning	NOUN
ct-9922	176	30	.	.	PUNCT
ct-9922	177	1	cell	cell	NOUN
ct-9922	177	2	res	re	NOUN
ct-9922	177	3	2011;21:979	2011;21:979	NUM
ct-9922	177	4	-	-	SYM
ct-9922	177	5	982	982	NUM
ct-9922	177	6	.	.	PUNCT
ct-9922	178	1	34	34	NUM
ct-9922	178	2	.	.	PUNCT
ct-9922	178	3	yu	yu	PROPN
ct-9922	178	4	s	s	PROPN
ct-9922	178	5	,	,	PUNCT
ct-9922	178	6	luo	luo	PROPN
ct-9922	178	7	j	j	PROPN
ct-9922	178	8	,	,	PUNCT
ct-9922	178	9	song	song	NOUN
ct-9922	178	10	z	z	PROPN
ct-9922	178	11	,	,	PUNCT
ct-9922	178	12	et	et	PROPN
ct-9922	178	13	al	al	PROPN
ct-9922	178	14	:	:	PUNCT
ct-9922	178	15	highly	highly	ADV
ct-9922	178	16	efficient	efficient	ADJ
ct-9922	178	17	modification	modification	NOUN
ct-9922	178	18	of	of	ADP
ct-9922	178	19	beta	beta	NOUN
ct-9922	178	20	-	-	PUNCT
ct-9922	178	21	lactoglobulin	lactoglobulin	NOUN
ct-9922	178	22	(	(	PUNCT
ct-9922	178	23	blg	blg	PROPN
ct-9922	178	24	)	)	PUNCT
ct-9922	178	25	gene	gene	NOUN
ct-9922	178	26	via	via	ADP
ct-9922	178	27	zinc	zinc	NOUN
ct-9922	178	28	-	-	PUNCT
ct-9922	178	29	finger	finger	NOUN
ct-9922	178	30	nucleases	nuclease	NOUN
ct-9922	178	31	in	in	ADP
ct-9922	178	32	cattle	cattle	NOUN
ct-9922	178	33	.	.	PUNCT
ct-9922	179	1	cell	cell	NOUN
ct-9922	179	2	res	re	NOUN
ct-9922	179	3	2011;21:1638	2011;21:1638	NOUN
ct-9922	179	4	.	.	PROPN
ct-9922	180	1	35	35	NUM
ct-9922	180	2	.	.	PUNCT
ct-9922	181	1	liu	liu	PROPN
ct-9922	181	2	x	x	PROPN
ct-9922	181	3	,	,	PUNCT
ct-9922	181	4	wang	wang	PROPN
ct-9922	181	5	y	y	PROPN
ct-9922	181	6	,	,	PUNCT
ct-9922	181	7	guo	guo	PROPN
ct-9922	181	8	w	w	PROPN
ct-9922	181	9	,	,	PUNCT
ct-9922	181	10	et	et	PROPN
ct-9922	181	11	al	al	PROPN
ct-9922	181	12	:	:	PUNCT
ct-9922	181	13	zinc	zinc	NOUN
ct-9922	181	14	-	-	PUNCT
ct-9922	181	15	finger	finger	NOUN
ct-9922	181	16	nickase	nickase	NOUN
ct-9922	181	17	-	-	PUNCT
ct-9922	181	18	mediated	mediate	VERB
ct-9922	181	19	insertion	insertion	NOUN
ct-9922	181	20	of	of	ADP
ct-9922	181	21	the	the	DET
ct-9922	181	22	lysostaphin	lysostaphin	ADJ
ct-9922	181	23	gene	gene	NOUN
ct-9922	181	24	into	into	ADP
ct-9922	181	25	the	the	DET
ct-9922	181	26	beta	beta	NOUN
ct-9922	181	27	-	-	PUNCT
ct-9922	181	28	casein	casein	NOUN
ct-9922	181	29	locus	locus	NOUN
ct-9922	181	30	in	in	ADP
ct-9922	181	31	cloned	cloned	ADJ
ct-9922	181	32	cows	cow	NOUN
ct-9922	181	33	.	.	PUNCT
ct-9922	182	1	nat	nat	PROPN
ct-9922	182	2	commun	commun	PROPN
ct-9922	182	3	2013;4:2565	2013;4:2565	PROPN
ct-9922	182	4	.	.	PUNCT
ct-9922	183	1	36	36	NUM
ct-9922	183	2	.	.	PUNCT
ct-9922	184	1	clop	clop	PROPN
ct-9922	184	2	a	a	PROPN
ct-9922	184	3	,	,	PUNCT
ct-9922	184	4	marcq	marcq	PROPN
ct-9922	184	5	f	f	PROPN
ct-9922	184	6	,	,	PUNCT
ct-9922	184	7	takeda	takeda	PROPN
ct-9922	184	8	h	h	PROPN
ct-9922	184	9	,	,	PUNCT
ct-9922	184	10	et	et	PROPN
ct-9922	184	11	al	al	PROPN
ct-9922	184	12	:	:	PUNCT
ct-9922	184	13	a	a	DET
ct-9922	184	14	mutation	mutation	NOUN
ct-9922	184	15	creating	create	VERB
ct-9922	184	16	a	a	DET
ct-9922	184	17	potential	potential	ADJ
ct-9922	184	18	illegitimate	illegitimate	ADJ
ct-9922	184	19	microrna	microrna	PROPN
ct-9922	184	20	target	target	NOUN
ct-9922	184	21	site	site	NOUN
ct-9922	184	22	in	in	ADP
ct-9922	184	23	the	the	DET
ct-9922	184	24	myostatin	myostatin	PROPN
ct-9922	184	25	gene	gene	NOUN
ct-9922	184	26	affects	affect	VERB
ct-9922	184	27	muscularity	muscularity	NOUN
ct-9922	184	28	in	in	ADP
ct-9922	184	29	sheep	sheep	NOUN
ct-9922	184	30	.	.	PUNCT
ct-9922	185	1	nat	nat	PROPN
ct-9922	185	2	genet	genet	PROPN
ct-9922	185	3	2006;38:813	2006;38:813	PROPN
ct-9922	185	4	-	-	PUNCT
ct-9922	185	5	818	818	NUM
ct-9922	185	6	.	.	PUNCT
ct-9922	186	1	37	37	NUM
ct-9922	186	2	.	.	PUNCT
ct-9922	187	1	grobet	grobet	PROPN
ct-9922	187	2	l	l	PROPN
ct-9922	187	3	,	,	PUNCT
ct-9922	187	4	martin	martin	PROPN
ct-9922	187	5	lj	lj	PROPN
ct-9922	187	6	,	,	PUNCT
ct-9922	187	7	poncelet	poncelet	NOUN
ct-9922	187	8	d	d	PROPN
ct-9922	187	9	,	,	PUNCT
ct-9922	187	10	et	et	PROPN
ct-9922	187	11	al	al	PROPN
ct-9922	187	12	:	:	PUNCT
ct-9922	187	13	a	a	DET
ct-9922	187	14	deletion	deletion	NOUN
ct-9922	187	15	in	in	ADP
ct-9922	187	16	the	the	DET
ct-9922	187	17	bovine	bovine	NOUN
ct-9922	187	18	myostatin	myostatin	NOUN
ct-9922	187	19	gene	gene	NOUN
ct-9922	187	20	causes	cause	VERB
ct-9922	187	21	the	the	DET
ct-9922	187	22	double	double	ADJ
ct-9922	187	23	-	-	PUNCT
ct-9922	187	24	muscled	muscle	VERB
ct-9922	187	25	phenotype	phenotype	NOUN
ct-9922	187	26	in	in	ADP
ct-9922	187	27	cattle	cattle	NOUN
ct-9922	187	28	.	.	PUNCT
ct-9922	188	1	nat	nat	PROPN
ct-9922	188	2	genet	genet	PROPN
ct-9922	188	3	1997;17:71	1997;17:71	NUM
ct-9922	188	4	-	-	SYM
ct-9922	188	5	74	74	NUM
ct-9922	188	6	.	.	PUNCT
ct-9922	188	7	38	38	NUM
ct-9922	188	8	.	.	PUNCT
ct-9922	189	1	qian	qian	PROPN
ct-9922	189	2	l	l	PROPN
ct-9922	189	3	,	,	PUNCT
ct-9922	189	4	tang	tang	PROPN
ct-9922	189	5	m	m	PROPN
ct-9922	189	6	,	,	PUNCT
ct-9922	189	7	yang	yang	PROPN
ct-9922	189	8	j	j	PROPN
ct-9922	189	9	,	,	PUNCT
ct-9922	189	10	et	et	PROPN
ct-9922	189	11	al	al	PROPN
ct-9922	189	12	:	:	PUNCT
ct-9922	189	13	targeted	target	VERB
ct-9922	189	14	mutations	mutation	NOUN
ct-9922	189	15	in	in	ADP
ct-9922	189	16	myostatin	myostatin	NOUN
ct-9922	189	17	by	by	ADP
ct-9922	189	18	zinc	zinc	NOUN
ct-9922	189	19	-	-	PUNCT
ct-9922	189	20	finger	finger	NOUN
ct-9922	189	21	nucleases	nuclease	NOUN
ct-9922	189	22	result	result	VERB
ct-9922	189	23	in	in	ADP
ct-9922	189	24	double	double	ADJ
ct-9922	189	25	-	-	PUNCT
ct-9922	189	26	muscled	muscle	VERB
ct-9922	189	27	phenotype	phenotype	NOUN
ct-9922	189	28	in	in	ADP
ct-9922	189	29	meishan	meishan	PROPN
ct-9922	189	30	pigs	pig	NOUN
ct-9922	189	31	.	.	PUNCT
ct-9922	190	1	sci	sci	PROPN
ct-9922	190	2	rep	rep	PROPN
ct-9922	190	3	2015;5:14435	2015;5:14435	PROPN
ct-9922	190	4	.	.	PUNCT
ct-9922	191	1	39	39	NUM
ct-9922	191	2	.	.	PUNCT
ct-9922	192	1	gaj	gaj	PROPN
ct-9922	192	2	t	t	PROPN
ct-9922	192	3	,	,	PUNCT
ct-9922	192	4	gersbach	gersbach	NOUN
ct-9922	192	5	ca	ca	NOUN
ct-9922	192	6	,	,	PUNCT
ct-9922	192	7	barbas	barbas	PROPN
ct-9922	192	8	cf	cf	NOUN
ct-9922	192	9	3rd	3rd	NOUN
ct-9922	192	10	:	:	PUNCT
ct-9922	192	11	zfn	zfn	NOUN
ct-9922	192	12	,	,	PUNCT
ct-9922	192	13	talen	talen	VERB
ct-9922	192	14	,	,	PUNCT
ct-9922	192	15	and	and	CCONJ
ct-9922	192	16	crispr	crispr	ADJ
ct-9922	192	17	/	/	SYM
ct-9922	192	18	cas	cas	NOUN
ct-9922	192	19	-	-	PUNCT
ct-9922	192	20	based	base	VERB
ct-9922	192	21	methods	method	NOUN
ct-9922	192	22	for	for	ADP
ct-9922	192	23	genome	genome	NOUN
ct-9922	192	24	engineering	engineering	NOUN
ct-9922	192	25	.	.	PUNCT
ct-9922	193	1	trends	trend	NOUN
ct-9922	193	2	biotechnol	biotechnol	VERB
ct-9922	193	3	2013;31:397	2013;31:397	NOUN
ct-9922	193	4	-	-	SYM
ct-9922	193	5	405	405	NUM
ct-9922	193	6	.	.	PUNCT
ct-9922	194	1	40	40	NUM
ct-9922	194	2	.	.	PUNCT
ct-9922	195	1	göhre	göhre	PROPN
ct-9922	195	2	v	v	NOUN
ct-9922	195	3	,	,	PUNCT
ct-9922	195	4	robatzek	robatzek	PROPN
ct-9922	195	5	s.	s.	PROPN
ct-9922	195	6	breaking	break	VERB
ct-9922	195	7	the	the	DET
ct-9922	195	8	barriers	barrier	NOUN
ct-9922	195	9	:	:	PUNCT
ct-9922	195	10	microbial	microbial	ADJ
ct-9922	195	11	effector	effector	NOUN
ct-9922	195	12	molecules	molecule	NOUN
ct-9922	195	13	subvert	subvert	VERB
ct-9922	195	14	plant	plant	NOUN
ct-9922	195	15	immunity	immunity	NOUN
ct-9922	195	16	.	.	PUNCT
ct-9922	196	1	annu	annu	PROPN
ct-9922	196	2	rev	rev	VERB
ct-9922	196	3	phytopathol	phytopathol	PROPN
ct-9922	196	4	2008;46:189	2008;46:189	PROPN
ct-9922	196	5	-	-	SYM
ct-9922	196	6	215	215	NUM
ct-9922	196	7	.	.	PUNCT
ct-9922	196	8	41	41	NUM
ct-9922	196	9	.	.	PUNCT
ct-9922	197	1	kay	kay	PROPN
ct-9922	197	2	s	s	PROPN
ct-9922	197	3	,	,	PUNCT
ct-9922	197	4	bonas	bona	NOUN
ct-9922	197	5	u	u	NOUN
ct-9922	197	6	:	:	PUNCT
ct-9922	197	7	how	how	SCONJ
ct-9922	197	8	xanthomonas	xanthomonas	PROPN
ct-9922	197	9	type	type	NOUN
ct-9922	197	10	iii	iii	NUM
ct-9922	197	11	effectors	effector	NOUN
ct-9922	197	12	manipulate	manipulate	VERB
ct-9922	197	13	the	the	DET
ct-9922	197	14	host	host	NOUN
ct-9922	197	15	plant	plant	NOUN
ct-9922	197	16	.	.	PUNCT
ct-9922	198	1	cur	cur	VERB
ct-9922	198	2	opin	opin	NOUN
ct-9922	198	3	microbiol	microbiol	NOUN
ct-9922	198	4	2009;12:37	2009;12:37	NUM
ct-9922	198	5	-	-	SYM
ct-9922	198	6	43	43	NUM
ct-9922	198	7	.	.	PUNCT
ct-9922	199	1	42	42	NUM
ct-9922	199	2	.	.	PUNCT
ct-9922	200	1	deng	deng	PROPN
ct-9922	200	2	d	d	PROPN
ct-9922	200	3	,	,	PUNCT
ct-9922	200	4	yan	yan	PROPN
ct-9922	200	5	c	c	X
ct-9922	200	6	,	,	PUNCT
ct-9922	200	7	pan	pan	NOUN
ct-9922	200	8	x	x	PROPN
ct-9922	200	9	,	,	PUNCT
ct-9922	200	10	et	et	PROPN
ct-9922	200	11	al	al	PROPN
ct-9922	200	12	:	:	PUNCT
ct-9922	200	13	structural	structural	ADJ
ct-9922	200	14	basis	basis	NOUN
ct-9922	200	15	for	for	ADP
ct-9922	200	16	sequence	sequence	NOUN
ct-9922	200	17	-	-	PUNCT
ct-9922	200	18	specific	specific	ADJ
ct-9922	200	19	recognition	recognition	NOUN
ct-9922	200	20	of	of	ADP
ct-9922	200	21	dna	dna	PROPN
ct-9922	200	22	by	by	ADP
ct-9922	200	23	tal	tal	ADJ
ct-9922	200	24	effectors	effector	NOUN
ct-9922	200	25	.	.	PUNCT
ct-9922	201	1	science	science	NOUN
ct-9922	201	2	2012;335:720	2012;335:720	NUM
ct-9922	201	3	-	-	SYM
ct-9922	201	4	723	723	NUM
ct-9922	201	5	.	.	NOUN
ct-9922	202	1	43	43	NUM
ct-9922	202	2	.	.	PUNCT
ct-9922	203	1	moscou	moscou	PROPN
ct-9922	203	2	mj	mj	PROPN
ct-9922	203	3	,	,	PUNCT
ct-9922	203	4	bogdanove	bogdanove	VERB
ct-9922	203	5	aj	aj	PROPN
ct-9922	203	6	:	:	PUNCT
ct-9922	203	7	a	a	DET
ct-9922	203	8	simple	simple	ADJ
ct-9922	203	9	cipher	cipher	ADJ
ct-9922	203	10	governs	govern	VERB
ct-9922	203	11	dna	dna	PROPN
ct-9922	203	12	recognition	recognition	NOUN
ct-9922	203	13	by	by	ADP
ct-9922	203	14	tal	tal	ADJ
ct-9922	203	15	effectors	effector	NOUN
ct-9922	203	16	.	.	PUNCT
ct-9922	204	1	science	science	NOUN
ct-9922	204	2	2009;326:1501	2009;326:1501	NUM
ct-9922	204	3	.	.	PUNCT
ct-9922	204	4	44	44	NUM
ct-9922	204	5	.	.	PUNCT
ct-9922	205	1	long	long	PROPN
ct-9922	205	2	cr	cr	PROPN
ct-9922	205	3	,	,	PUNCT
ct-9922	205	4	gregory	gregory	PROPN
ct-9922	205	5	ke	ke	PROPN
ct-9922	205	6	:	:	PUNCT
ct-9922	205	7	inheritance	inheritance	NOUN
ct-9922	205	8	of	of	ADP
ct-9922	205	9	the	the	DET
ct-9922	205	10	horned	horn	VERB
ct-9922	205	11	,	,	PUNCT
ct-9922	205	12	scurred	scurred	ADJ
ct-9922	205	13	,	,	PUNCT
ct-9922	205	14	and	and	CCONJ
ct-9922	205	15	polled	poll	VERB
ct-9922	205	16	condition	condition	NOUN
ct-9922	205	17	in	in	ADP
ct-9922	205	18	cattle	cattle	NOUN
ct-9922	205	19	.	.	PUNCT
ct-9922	206	1	j	j	PROPN
ct-9922	206	2	hered	here	VERB
ct-9922	206	3	1978;69:395	1978;69:395	NUM
ct-9922	206	4	-	-	SYM
ct-9922	206	5	400	400	NUM
ct-9922	206	6	.	.	PUNCT
ct-9922	207	1	45	45	NUM
ct-9922	207	2	.	.	PUNCT
ct-9922	208	1	carlson	carlson	PROPN
ct-9922	208	2	df	df	PROPN
ct-9922	208	3	,	,	PUNCT
ct-9922	208	4	lancto	lancto	PROPN
ct-9922	208	5	ca	ca	PROPN
ct-9922	208	6	,	,	PUNCT
ct-9922	208	7	zang	zang	PROPN
ct-9922	208	8	b	b	PROPN
ct-9922	208	9	,	,	PUNCT
ct-9922	208	10	et	et	PROPN
ct-9922	208	11	al	al	PROPN
ct-9922	208	12	:	:	PUNCT
ct-9922	208	13	production	production	NOUN
ct-9922	208	14	of	of	ADP
ct-9922	208	15	hornless	hornless	NOUN
ct-9922	208	16	dairy	dairy	NOUN
ct-9922	208	17	cattle	cattle	NOUN
ct-9922	208	18	from	from	ADP
ct-9922	208	19	genome	genome	NOUN
ct-9922	208	20	-	-	PUNCT
ct-9922	208	21	edited	edit	VERB
ct-9922	208	22	cell	cell	NOUN
ct-9922	208	23	lines	line	NOUN
ct-9922	208	24	.	.	PUNCT
ct-9922	209	1	nat	nat	PROPN
ct-9922	209	2	biotechnol	biotechnol	PROPN
ct-9922	209	3	2016;34:479	2016;34:479	PROPN
ct-9922	209	4	.	.	PUNCT
ct-9922	210	1	46	46	NUM
ct-9922	210	2	.	.	PUNCT
ct-9922	211	1	proudfoot	proudfoot	PROPN
ct-9922	211	2	c	c	PROPN
ct-9922	211	3	,	,	PUNCT
ct-9922	211	4	carlson	carlson	PROPN
ct-9922	211	5	df	df	PROPN
ct-9922	211	6	,	,	PUNCT
ct-9922	211	7	huddart	huddart	NOUN
ct-9922	211	8	r	r	NOUN
ct-9922	211	9	,	,	PUNCT
ct-9922	211	10	et	et	PROPN
ct-9922	211	11	al	al	PROPN
ct-9922	211	12	:	:	PUNCT
ct-9922	211	13	genome	genome	NOUN
ct-9922	211	14	edited	edit	VERB
ct-9922	211	15	sheep	sheep	NOUN
ct-9922	211	16	and	and	CCONJ
ct-9922	211	17	cattle	cattle	NOUN
ct-9922	211	18	.	.	PUNCT
ct-9922	212	1	transgenic	transgenic	NOUN
ct-9922	212	2	res	re	NOUN
ct-9922	212	3	2015;24:147	2015;24:147	NUM
ct-9922	212	4	-	-	PUNCT
ct-9922	212	5	153	153	NUM
ct-9922	212	6	.	.	PUNCT
ct-9922	213	1	47	47	NUM
ct-9922	213	2	.	.	PUNCT
ct-9922	214	1	yu	yu	PROPN
ct-9922	215	1	b	b	PROPN
ct-9922	215	2	,	,	PUNCT
ct-9922	215	3	lu	lu	PROPN
ct-9922	215	4	r	r	PROPN
ct-9922	215	5	,	,	PUNCT
ct-9922	215	6	yuan	yuan	PROPN
ct-9922	215	7	y	y	PROPN
ct-9922	215	8	,	,	PUNCT
ct-9922	215	9	et	et	PROPN
ct-9922	215	10	al	al	PROPN
ct-9922	215	11	:	:	PUNCT
ct-9922	215	12	efficient	efficient	ADJ
ct-9922	215	13	talen	talen	NOUN
ct-9922	215	14	-	-	PUNCT
ct-9922	215	15	mediated	mediate	VERB
ct-9922	215	16	myostatin	myostatin	ADJ
ct-9922	215	17	gene	gene	NOUN
ct-9922	215	18	editing	edit	VERB
ct-9922	215	19	in	in	ADP
ct-9922	215	20	goats	goat	NOUN
ct-9922	215	21	.	.	PUNCT
ct-9922	216	1	bmc	bmc	PROPN
ct-9922	216	2	dev	dev	PROPN
ct-9922	216	3	biol	biol	PROPN
ct-9922	216	4	2016;16:26	2016;16:26	NUM
ct-9922	216	5	.	.	PUNCT
ct-9922	217	1	48	48	NUM
ct-9922	217	2	.	.	PUNCT
ct-9922	218	1	wu	wu	PROPN
ct-9922	218	2	h	h	PROPN
ct-9922	218	3	,	,	PUNCT
ct-9922	218	4	wang	wang	PROPN
ct-9922	218	5	y	y	PROPN
ct-9922	218	6	,	,	PUNCT
ct-9922	218	7	zhang	zhang	PROPN
ct-9922	218	8	y	y	PROPN
ct-9922	218	9	,	,	PUNCT
ct-9922	218	10	et	et	PROPN
ct-9922	218	11	al	al	PROPN
ct-9922	218	12	:	:	PUNCT
ct-9922	218	13	tale	tale	PROPN
ct-9922	218	14	nickase	nickase	NOUN
ct-9922	218	15	-	-	PUNCT
ct-9922	218	16	mediated	mediate	VERB
ct-9922	218	17	sp110	sp110	PROPN
ct-9922	218	18	knockin	knockin	NOUN
ct-9922	218	19	endows	endow	VERB
ct-9922	218	20	cattle	cattle	NOUN
ct-9922	218	21	with	with	ADP
ct-9922	218	22	increased	increase	VERB
ct-9922	218	23	resistance	resistance	NOUN
ct-9922	218	24	to	to	ADP
ct-9922	218	25	tuberculosis	tuberculosis	NOUN
ct-9922	218	26	.	.	PUNCT
ct-9922	219	1	proc	proc	PROPN
ct-9922	219	2	nat	nat	PROPN
ct-9922	219	3	acad	acad	PROPN
ct-9922	219	4	sci	sci	PROPN
ct-9922	219	5	2015;112	2015;112	NUM
ct-9922	219	6	:	:	PUNCT
ct-9922	219	7	e1530	e1530	PROPN
ct-9922	219	8	-	-	PUNCT
ct-9922	219	9	e1539	e1539	NOUN
ct-9922	219	10	.	.	PROPN
ct-9922	220	1	49	49	NUM
ct-9922	220	2	.	.	PUNCT
ct-9922	221	1	horvath	horvath	PROPN
ct-9922	221	2	p	p	PROPN
ct-9922	221	3	,	,	PUNCT
ct-9922	221	4	barrangou	barrangou	PROPN
ct-9922	221	5	r	r	NOUN
ct-9922	221	6	:	:	PUNCT
ct-9922	221	7	crispr	crispr	PROPN
ct-9922	221	8	/	/	SYM
ct-9922	221	9	cas	cas	PROPN
ct-9922	221	10	,	,	PUNCT
ct-9922	221	11	the	the	DET
ct-9922	221	12	immune	immune	ADJ
ct-9922	221	13	system	system	NOUN
ct-9922	221	14	of	of	ADP
ct-9922	221	15	bacteria	bacteria	NOUN
ct-9922	221	16	and	and	CCONJ
ct-9922	221	17	archaea	archaea	NOUN
ct-9922	221	18	.	.	PUNCT
ct-9922	222	1	science	science	NOUN
ct-9922	222	2	2010;327:167	2010;327:167	NUM
ct-9922	222	3	-	-	SYM
ct-9922	222	4	170	170	NUM
ct-9922	222	5	.	.	PUNCT
ct-9922	222	6	50	50	NUM
ct-9922	222	7	.	.	PUNCT
ct-9922	223	1	wiedenheft	wiedenheft	PROPN
ct-9922	223	2	b	b	PROPN
ct-9922	223	3	,	,	PUNCT
ct-9922	223	4	sternberg	sternberg	PROPN
ct-9922	223	5	sh	sh	PROPN
ct-9922	223	6	,	,	PUNCT
ct-9922	223	7	doudna	doudna	VERB
ct-9922	223	8	ja	ja	PROPN
ct-9922	223	9	:	:	PUNCT
ct-9922	223	10	rna	rna	NOUN
ct-9922	223	11	-	-	PUNCT
ct-9922	223	12	guided	guide	VERB
ct-9922	223	13	genetic	genetic	ADJ
ct-9922	223	14	silencing	silence	VERB
ct-9922	223	15	systems	system	NOUN
ct-9922	223	16	in	in	ADP
ct-9922	223	17	bacteria	bacteria	NOUN
ct-9922	223	18	and	and	CCONJ
ct-9922	223	19	archaea	archaea	NOUN
ct-9922	223	20	.	.	PUNCT
ct-9922	224	1	nature	nature	NOUN
ct-9922	224	2	2012;482:331	2012;482:331	NUM
ct-9922	224	3	.	.	PUNCT
ct-9922	225	1	51	51	NUM
ct-9922	225	2	.	.	PUNCT
ct-9922	226	1	jinek	jinek	PROPN
ct-9922	226	2	m	m	PROPN
ct-9922	226	3	,	,	PUNCT
ct-9922	226	4	chylinski	chylinski	PROPN
ct-9922	226	5	k	k	PROPN
ct-9922	226	6	,	,	PUNCT
ct-9922	227	1	fonfara	fonfara	PROPN
ct-9922	227	2	i	i	PRON
ct-9922	227	3	,	,	PUNCT
ct-9922	227	4	et	et	PROPN
ct-9922	227	5	al	al	PROPN
ct-9922	227	6	:	:	PUNCT
ct-9922	227	7	a	a	DET
ct-9922	227	8	programmable	programmable	ADJ
ct-9922	227	9	dual	dual	ADJ
ct-9922	227	10	-	-	PUNCT
ct-9922	227	11	rna	rna	NOUN
ct-9922	227	12	–	–	PUNCT
ct-9922	227	13	guided	guide	VERB
ct-9922	227	14	dna	dna	NOUN
ct-9922	227	15	endonuclease	endonuclease	NOUN
ct-9922	227	16	in	in	ADP
ct-9922	227	17	adaptive	adaptive	ADJ
ct-9922	227	18	bacterial	bacterial	ADJ
ct-9922	227	19	immunity	immunity	NOUN
ct-9922	227	20	.	.	PUNCT
ct-9922	228	1	science	science	NOUN
ct-9922	228	2	2012:337:816	2012:337:816	NUM
ct-9922	228	3	-	-	SYM
ct-9922	228	4	821	821	NUM
ct-9922	228	5	.	.	PUNCT
ct-9922	229	1	clinical	clinical	ADJ
ct-9922	229	2	theriogenology	theriogenology	NOUN
ct-9922	229	3	•	•	NOUN
ct-9922	229	4	volume	volume	NOUN
ct-9922	229	5	10	10	NUM
ct-9922	229	6	,	,	PUNCT
ct-9922	229	7	number	number	NOUN
ct-9922	229	8	3	3	NUM
ct-9922	229	9	•	•	NUM
ct-9922	229	10	september	september	PROPN
ct-9922	229	11	2018	2018	NUM
ct-9922	229	12	244	244	NUM
ct-9922	229	13	52	52	NUM
ct-9922	229	14	.	.	PUNCT
ct-9922	230	1	cong	cong	NOUN
ct-9922	230	2	l	l	PROPN
ct-9922	230	3	,	,	PUNCT
ct-9922	230	4	ran	run	VERB
ct-9922	230	5	fa	fa	PROPN
ct-9922	230	6	,	,	PUNCT
ct-9922	230	7	cox	cox	PROPN
ct-9922	230	8	d	d	PROPN
ct-9922	230	9	,	,	PUNCT
ct-9922	230	10	et	et	PROPN
ct-9922	230	11	al	al	PROPN
ct-9922	230	12	:	:	PUNCT
ct-9922	230	13	multiplex	multiplex	PROPN
ct-9922	230	14	genome	genome	NOUN
ct-9922	230	15	engineering	engineering	NOUN
ct-9922	230	16	using	use	VERB
ct-9922	230	17	crispr	crispr	ADJ
ct-9922	230	18	/	/	SYM
ct-9922	230	19	cas	cas	NOUN
ct-9922	230	20	systems	system	NOUN
ct-9922	230	21	.	.	PUNCT
ct-9922	231	1	science	science	NOUN
ct-9922	231	2	2013;339:819	2013;339:819	NUM
ct-9922	231	3	-	-	SYM
ct-9922	231	4	823	823	NUM
ct-9922	231	5	.	.	PUNCT
ct-9922	231	6	53	53	NUM
ct-9922	231	7	.	.	PUNCT
ct-9922	232	1	hai	hai	PROPN
ct-9922	232	2	t	t	PROPN
ct-9922	232	3	,	,	PUNCT
ct-9922	232	4	teng	teng	PROPN
ct-9922	232	5	f	f	PROPN
ct-9922	232	6	,	,	PUNCT
ct-9922	232	7	guo	guo	PROPN
ct-9922	232	8	r	r	PROPN
ct-9922	232	9	,	,	PUNCT
ct-9922	232	10	et	et	PROPN
ct-9922	232	11	al	al	PROPN
ct-9922	232	12	:	:	PUNCT
ct-9922	232	13	one	one	NUM
ct-9922	232	14	-	-	PUNCT
ct-9922	232	15	step	step	NOUN
ct-9922	232	16	generation	generation	NOUN
ct-9922	232	17	of	of	ADP
ct-9922	232	18	knockout	knockout	NOUN
ct-9922	232	19	pigs	pig	NOUN
ct-9922	232	20	by	by	ADP
ct-9922	232	21	zygote	zygote	ADJ
ct-9922	232	22	injection	injection	NOUN
ct-9922	232	23	of	of	ADP
ct-9922	232	24	crispr	crispr	ADJ
ct-9922	232	25	/	/	SYM
ct-9922	232	26	cas	cas	NOUN
ct-9922	232	27	system	system	NOUN
ct-9922	232	28	.	.	PUNCT
ct-9922	233	1	cell	cell	NOUN
ct-9922	233	2	res	re	NOUN
ct-9922	233	3	2014;24:372	2014;24:372	PROPN
ct-9922	233	4	-	-	SYM
ct-9922	233	5	375	375	NUM
ct-9922	233	6	.	.	PUNCT
ct-9922	234	1	54	54	NUM
ct-9922	234	2	.	.	PUNCT
ct-9922	235	1	whitworth	whitworth	PROPN
ct-9922	235	2	km	km	PROPN
ct-9922	235	3	,	,	PUNCT
ct-9922	235	4	rowland	rowland	PROPN
ct-9922	235	5	rr	rr	PROPN
ct-9922	235	6	,	,	PUNCT
ct-9922	235	7	ewen	ewen	PROPN
ct-9922	235	8	cl	cl	PROPN
ct-9922	235	9	,	,	PUNCT
ct-9922	235	10	et	et	PROPN
ct-9922	235	11	al	al	PROPN
ct-9922	235	12	:	:	PUNCT
ct-9922	235	13	gene	gene	NOUN
ct-9922	235	14	-	-	PUNCT
ct-9922	235	15	edited	edit	VERB
ct-9922	235	16	pigs	pig	NOUN
ct-9922	235	17	are	be	AUX
ct-9922	235	18	protected	protect	VERB
ct-9922	235	19	from	from	ADP
ct-9922	235	20	porcine	porcine	NOUN
ct-9922	235	21	reproductive	reproductive	ADJ
ct-9922	235	22	and	and	CCONJ
ct-9922	235	23	respiratory	respiratory	ADJ
ct-9922	235	24	syndrome	syndrome	NOUN
ct-9922	235	25	virus	virus	NOUN
ct-9922	235	26	.	.	PUNCT
ct-9922	236	1	nat	nat	PROPN
ct-9922	236	2	biotechnol	biotechnol	PROPN
ct-9922	236	3	2015;34:20	2015;34:20	PROPN
ct-9922	236	4	.	.	PUNCT
ct-9922	237	1	55	55	NUM
ct-9922	237	2	.	.	PUNCT
ct-9922	238	1	whitworth	whitworth	PROPN
ct-9922	238	2	km	km	PROPN
ct-9922	238	3	,	,	PUNCT
ct-9922	238	4	lee	lee	PROPN
ct-9922	238	5	k	k	PROPN
ct-9922	238	6	,	,	PUNCT
ct-9922	238	7	benne	benne	PROPN
ct-9922	238	8	ja	ja	PROPN
ct-9922	238	9	,	,	PUNCT
ct-9922	238	10	et	et	PROPN
ct-9922	238	11	al	al	PROPN
ct-9922	238	12	:	:	PUNCT
ct-9922	238	13	use	use	NOUN
ct-9922	238	14	of	of	ADP
ct-9922	238	15	the	the	DET
ct-9922	238	16	crispr	crispr	ADJ
ct-9922	238	17	/	/	SYM
ct-9922	238	18	cas9	cas9	NOUN
ct-9922	238	19	system	system	NOUN
ct-9922	238	20	to	to	PART
ct-9922	238	21	produce	produce	VERB
ct-9922	238	22	genetically	genetically	ADV
ct-9922	238	23	engineered	engineer	VERB
ct-9922	238	24	pigs	pig	NOUN
ct-9922	238	25	from	from	ADP
ct-9922	238	26	in	in	ADP
ct-9922	238	27	vitro	vitro	X
ct-9922	238	28	-	-	PUNCT
ct-9922	238	29	derived	derive	VERB
ct-9922	238	30	oocytes	oocyte	NOUN
ct-9922	238	31	and	and	CCONJ
ct-9922	238	32	embryos	embryo	NOUN
ct-9922	238	33	.	.	PUNCT
ct-9922	239	1	biol	biol	PROPN
ct-9922	239	2	reprod	reprod	PROPN
ct-9922	239	3	2014;91:78	2014;91:78	NUM
ct-9922	239	4	.	.	PUNCT
ct-9922	240	1	56	56	NUM
ct-9922	240	2	.	.	PUNCT
ct-9922	241	1	prather	prather	PROPN
ct-9922	241	2	rs	rs	PROPN
ct-9922	241	3	,	,	PUNCT
ct-9922	241	4	rowland	rowland	PROPN
ct-9922	241	5	rr	rr	PROPN
ct-9922	241	6	,	,	PUNCT
ct-9922	241	7	ewen	ewen	PROPN
ct-9922	241	8	c	c	PROPN
ct-9922	241	9	,	,	PUNCT
ct-9922	241	10	et	et	PROPN
ct-9922	241	11	al	al	PROPN
ct-9922	241	12	:	:	PUNCT
ct-9922	241	13	an	an	DET
ct-9922	241	14	intact	intact	ADJ
ct-9922	241	15	sialoadhesin	sialoadhesin	NOUN
ct-9922	241	16	(	(	PUNCT
ct-9922	241	17	sn	sn	NOUN
ct-9922	241	18	/	/	SYM
ct-9922	241	19	siglec1	siglec1	NOUN
ct-9922	241	20	/	/	SYM
ct-9922	241	21	cd169	cd169	PROPN
ct-9922	241	22	)	)	PUNCT
ct-9922	241	23	is	be	AUX
ct-9922	241	24	not	not	PART
ct-9922	241	25	required	require	VERB
ct-9922	241	26	for	for	ADP
ct-9922	241	27	attachment	attachment	NOUN
ct-9922	241	28	/	/	SYM
ct-9922	241	29	internalization	internalization	NOUN
ct-9922	241	30	of	of	ADP
ct-9922	241	31	the	the	DET
ct-9922	241	32	porcine	porcine	NOUN
ct-9922	241	33	reproductive	reproductive	ADJ
ct-9922	241	34	and	and	CCONJ
ct-9922	241	35	respiratory	respiratory	ADJ
ct-9922	241	36	syndrome	syndrome	NOUN
ct-9922	241	37	virus	virus	NOUN
ct-9922	241	38	.	.	PUNCT
ct-9922	242	1	j	j	PROPN
ct-9922	242	2	virol	virol	PROPN
ct-9922	242	3	2013;87:9538	2013;87:9538	NUM
ct-9922	242	4	-	-	SYM
ct-9922	242	5	9546	9546	NUM
ct-9922	242	6	.	.	PUNCT
ct-9922	243	1	57	57	NUM
ct-9922	243	2	.	.	PUNCT
ct-9922	244	1	lei	lei	PROPN
ct-9922	244	2	s	s	PROPN
ct-9922	244	3	,	,	PUNCT
ct-9922	244	4	ryu	ryu	PROPN
ct-9922	244	5	j	j	PROPN
ct-9922	244	6	,	,	PUNCT
ct-9922	244	7	wen	wen	PROPN
ct-9922	244	8	k	k	PROPN
ct-9922	244	9	,	,	PUNCT
ct-9922	244	10	et	et	PROPN
ct-9922	244	11	al	al	PROPN
ct-9922	244	12	:	:	PUNCT
ct-9922	244	13	increased	increase	VERB
ct-9922	244	14	and	and	CCONJ
ct-9922	244	15	prolonged	prolong	VERB
ct-9922	244	16	human	human	ADJ
ct-9922	244	17	norovirus	noroviru	NOUN
ct-9922	244	18	infection	infection	NOUN
ct-9922	244	19	in	in	ADP
ct-9922	244	20	rag2	rag2	PROPN
ct-9922	244	21	/	/	SYM
ct-9922	244	22	il2rg	il2rg	NOUN
ct-9922	244	23	deficient	deficient	ADJ
ct-9922	244	24	gnotobiotic	gnotobiotic	ADJ
ct-9922	244	25	pigs	pig	NOUN
ct-9922	244	26	with	with	ADP
ct-9922	244	27	severe	severe	ADJ
ct-9922	244	28	combined	combined	ADJ
ct-9922	244	29	immunodeficiency	immunodeficiency	NOUN
ct-9922	244	30	.	.	PUNCT
ct-9922	245	1	sci	sci	PROPN
ct-9922	245	2	rep	rep	PROPN
ct-9922	245	3	2016;6:25222	2016;6:25222	PROPN
ct-9922	245	4	.	.	PUNCT
ct-9922	246	1	58	58	NUM
ct-9922	246	2	.	.	PUNCT
ct-9922	247	1	ryu	ryu	PROPN
ct-9922	247	2	j	j	PROPN
ct-9922	247	3	,	,	PUNCT
ct-9922	247	4	prather	prather	NOUN
ct-9922	247	5	rs	rs	PROPN
ct-9922	247	6	,	,	PUNCT
ct-9922	247	7	lee	lee	PROPN
ct-9922	247	8	k	k	NOUN
ct-9922	247	9	:	:	PUNCT
ct-9922	247	10	use	use	NOUN
ct-9922	247	11	of	of	ADP
ct-9922	247	12	gene	gene	NOUN
ct-9922	247	13	-	-	PUNCT
ct-9922	247	14	editing	edit	VERB
ct-9922	247	15	technology	technology	NOUN
ct-9922	247	16	to	to	PART
ct-9922	247	17	introduce	introduce	VERB
ct-9922	247	18	targeted	target	VERB
ct-9922	247	19	modifications	modification	NOUN
ct-9922	247	20	in	in	ADP
ct-9922	247	21	pigs	pig	NOUN
ct-9922	247	22	.	.	PUNCT
ct-9922	248	1	j	j	PROPN
ct-9922	248	2	anim	anim	NOUN
ct-9922	248	3	sci	sci	PROPN
ct-9922	248	4	biotechnol	biotechnol	PROPN
ct-9922	248	5	2018;9:5	2018;9:5	NOUN
ct-9922	248	6	.	.	PUNCT
ct-9922	249	1	59	59	NUM
ct-9922	249	2	.	.	PUNCT
ct-9922	249	3	bevacqua	bevacqua	PROPN
ct-9922	249	4	r	r	PROPN
ct-9922	249	5	,	,	PUNCT
ct-9922	249	6	fernandez	fernandez	NOUN
ct-9922	249	7	-	-	PUNCT
ct-9922	249	8	martín	martín	NOUN
ct-9922	249	9	r	r	NOUN
ct-9922	249	10	,	,	PUNCT
ct-9922	249	11	savy	savy	ADJ
ct-9922	249	12	v	v	PROPN
ct-9922	249	13	,	,	PUNCT
ct-9922	249	14	et	et	PROPN
ct-9922	249	15	al	al	PROPN
ct-9922	249	16	:	:	PUNCT
ct-9922	249	17	efficient	efficient	ADJ
ct-9922	249	18	edition	edition	NOUN
ct-9922	249	19	of	of	ADP
ct-9922	249	20	the	the	DET
ct-9922	249	21	bovine	bovine	PROPN
ct-9922	249	22	prnp	prnp	PROPN
ct-9922	249	23	prion	prion	NOUN
ct-9922	249	24	gene	gene	NOUN
ct-9922	249	25	in	in	ADP
ct-9922	249	26	somatic	somatic	ADJ
ct-9922	249	27	cells	cell	NOUN
ct-9922	249	28	and	and	CCONJ
ct-9922	249	29	ivf	ivf	NOUN
ct-9922	249	30	embryos	embryo	NOUN
ct-9922	249	31	using	use	VERB
ct-9922	249	32	the	the	DET
ct-9922	249	33	crispr	crispr	ADJ
ct-9922	249	34	/	/	SYM
ct-9922	249	35	cas9	cas9	NOUN
ct-9922	249	36	system	system	NOUN
ct-9922	249	37	.	.	PUNCT
ct-9922	250	1	theriogenology	theriogenology	NOUN
ct-9922	250	2	2016;86:1886	2016;86:1886	PROPN
ct-9922	250	3	-	-	SYM
ct-9922	250	4	1896	1896	NUM
ct-9922	250	5	.	.	PUNCT
ct-9922	251	1	60	60	NUM
ct-9922	251	2	.	.	PUNCT
ct-9922	252	1	choi	choi	PROPN
ct-9922	252	2	w	w	PROPN
ct-9922	252	3	,	,	PUNCT
ct-9922	252	4	kim	kim	PROPN
ct-9922	252	5	e	e	PROPN
ct-9922	252	6	,	,	PUNCT
ct-9922	252	7	yum	yum	PROPN
ct-9922	252	8	s	s	PROPN
ct-9922	252	9	-	-	PUNCT
ct-9922	252	10	y	y	PROPN
ct-9922	252	11	,	,	PUNCT
ct-9922	252	12	et	et	PROPN
ct-9922	252	13	al	al	PROPN
ct-9922	252	14	:	:	PUNCT
ct-9922	252	15	efficient	efficient	ADJ
ct-9922	252	16	prnp	prnp	PROPN
ct-9922	252	17	deletion	deletion	NOUN
ct-9922	252	18	in	in	ADP
ct-9922	252	19	bovine	bovine	NOUN
ct-9922	252	20	genome	genome	NOUN
ct-9922	252	21	using	use	VERB
ct-9922	252	22	gene	gene	NOUN
ct-9922	252	23	-	-	PUNCT
ct-9922	252	24	editing	edit	VERB
ct-9922	252	25	technologies	technology	NOUN
ct-9922	252	26	in	in	ADP
ct-9922	252	27	bovine	bovine	ADJ
ct-9922	252	28	cells	cell	NOUN
ct-9922	252	29	.	.	PUNCT
ct-9922	253	1	prion	prion	NOUN
ct-9922	253	2	2015;9:278	2015;9:278	NUM
ct-9922	253	3	-	-	SYM
ct-9922	253	4	291	291	NUM
ct-9922	253	5	.	.	PUNCT
ct-9922	253	6	61	61	NUM
ct-9922	253	7	.	.	PUNCT
ct-9922	254	1	kuroiwa	kuroiwa	PROPN
ct-9922	254	2	y	y	PROPN
ct-9922	254	3	,	,	PUNCT
ct-9922	254	4	kasinathan	kasinathan	PROPN
ct-9922	254	5	p	p	PROPN
ct-9922	254	6	,	,	PUNCT
ct-9922	254	7	matsushita	matsushita	PROPN
ct-9922	254	8	h	h	PROPN
ct-9922	254	9	,	,	PUNCT
ct-9922	254	10	et	et	PROPN
ct-9922	254	11	al	al	PROPN
ct-9922	254	12	:	:	PUNCT
ct-9922	254	13	sequential	sequential	ADJ
ct-9922	254	14	targeting	targeting	NOUN
ct-9922	254	15	of	of	ADP
ct-9922	254	16	the	the	DET
ct-9922	254	17	genes	gene	NOUN
ct-9922	254	18	encoding	encode	VERB
ct-9922	254	19	immunoglobulin	immunoglobulin	NOUN
ct-9922	254	20	-	-	PUNCT
ct-9922	254	21	mu	mu	NOUN
ct-9922	254	22	and	and	CCONJ
ct-9922	254	23	prion	prion	NOUN
ct-9922	254	24	protein	protein	NOUN
ct-9922	254	25	in	in	ADP
ct-9922	254	26	cattle	cattle	NOUN
ct-9922	254	27	.	.	PUNCT
ct-9922	255	1	nat	nat	PROPN
ct-9922	255	2	genet	genet	PROPN
ct-9922	255	3	2004;36:775	2004;36:775	PROPN
ct-9922	255	4	-	-	PUNCT
ct-9922	255	5	780	780	NUM
ct-9922	255	6	.	.	PUNCT
ct-9922	256	1	62	62	NUM
ct-9922	256	2	.	.	PUNCT
ct-9922	257	1	hübner	hübner	NOUN
ct-9922	257	2	a	a	NOUN
ct-9922	257	3	,	,	PUNCT
ct-9922	257	4	petersen	petersen	PROPN
ct-9922	257	5	b	b	PROPN
ct-9922	257	6	,	,	PUNCT
ct-9922	257	7	keil	keil	PROPN
ct-9922	257	8	gm	gm	PROPN
ct-9922	257	9	,	,	PUNCT
ct-9922	257	10	et	et	PROPN
ct-9922	257	11	al	al	PROPN
ct-9922	257	12	:	:	PUNCT
ct-9922	257	13	efficient	efficient	ADJ
ct-9922	257	14	inhibition	inhibition	NOUN
ct-9922	257	15	of	of	ADP
ct-9922	257	16	african	african	ADJ
ct-9922	257	17	swine	swine	ADJ
ct-9922	257	18	fever	fever	NOUN
ct-9922	257	19	virus	virus	NOUN
ct-9922	257	20	replication	replication	NOUN
ct-9922	257	21	by	by	ADP
ct-9922	257	22	crispr	crispr	NOUN
ct-9922	257	23	/	/	SYM
ct-9922	257	24	cas9	cas9	NOUN
ct-9922	257	25	targeting	targeting	NOUN
ct-9922	257	26	of	of	ADP
ct-9922	257	27	the	the	DET
ct-9922	257	28	viral	viral	ADJ
ct-9922	257	29	p30	p30	NOUN
ct-9922	257	30	gene	gene	NOUN
ct-9922	257	31	(	(	PUNCT
ct-9922	257	32	cp204l	cp204l	PROPN
ct-9922	257	33	)	)	PUNCT
ct-9922	257	34	.	.	PUNCT
ct-9922	258	1	sci	sci	PROPN
ct-9922	258	2	rep	rep	PROPN
ct-9922	258	3	2018;8:1449	2018;8:1449	PROPN
ct-9922	258	4	.	.	PUNCT
ct-9922	259	1	63	63	NUM
ct-9922	259	2	.	.	PUNCT
ct-9922	260	1	hirano	hirano	PROPN
ct-9922	260	2	t	t	PROPN
ct-9922	260	3	,	,	PUNCT
ct-9922	260	4	kobayashi	kobayashi	PROPN
ct-9922	260	5	n	n	CCONJ
ct-9922	260	6	,	,	PUNCT
ct-9922	260	7	matsuhashi	matsuhashi	PROPN
ct-9922	260	8	t	t	PROPN
ct-9922	260	9	,	,	PUNCT
ct-9922	260	10	et	et	PROPN
ct-9922	260	11	al	al	PROPN
ct-9922	260	12	:	:	PUNCT
ct-9922	260	13	mapping	mapping	NOUN
ct-9922	260	14	and	and	CCONJ
ct-9922	260	15	exome	exome	NOUN
ct-9922	260	16	sequencing	sequencing	NOUN
ct-9922	260	17	identifies	identify	VERB
ct-9922	260	18	a	a	DET
ct-9922	260	19	mutation	mutation	NOUN
ct-9922	260	20	in	in	ADP
ct-9922	260	21	the	the	DET
ct-9922	260	22	iars	iar	NOUN
ct-9922	260	23	gene	gene	NOUN
ct-9922	260	24	as	as	ADP
ct-9922	260	25	the	the	DET
ct-9922	260	26	cause	cause	NOUN
ct-9922	260	27	of	of	ADP
ct-9922	260	28	hereditary	hereditary	ADJ
ct-9922	260	29	perinatal	perinatal	ADJ
ct-9922	260	30	weak	weak	ADJ
ct-9922	260	31	calf	calf	NOUN
ct-9922	260	32	syndrome	syndrome	NOUN
ct-9922	260	33	.	.	PUNCT
ct-9922	261	1	plos	plos	PROPN
ct-9922	261	2	one	one	NUM
ct-9922	261	3	2013;8	2013;8	NUM
ct-9922	261	4	:	:	PUNCT
ct-9922	261	5	e64036	e64036	NOUN
ct-9922	261	6	.	.	PROPN
ct-9922	261	7	64	64	NUM
ct-9922	261	8	.	.	PUNCT
ct-9922	262	1	ikeda	ikeda	PROPN
ct-9922	262	2	m	m	PROPN
ct-9922	262	3	,	,	PUNCT
ct-9922	262	4	matsuyama	matsuyama	PROPN
ct-9922	262	5	s	s	PROPN
ct-9922	262	6	,	,	PUNCT
ct-9922	262	7	akagi	akagi	PROPN
ct-9922	262	8	s	s	PROPN
ct-9922	262	9	,	,	PUNCT
ct-9922	262	10	et	et	PROPN
ct-9922	262	11	al	al	PROPN
ct-9922	262	12	:	:	PUNCT
ct-9922	262	13	correction	correction	NOUN
ct-9922	262	14	of	of	ADP
ct-9922	262	15	a	a	DET
ct-9922	262	16	disease	disease	NOUN
ct-9922	262	17	mutation	mutation	NOUN
ct-9922	262	18	using	use	VERB
ct-9922	262	19	crispr	crispr	ADJ
ct-9922	262	20	/	/	SYM
ct-9922	262	21	cas9	cas9	NOUN
ct-9922	262	22	-	-	PUNCT
ct-9922	262	23	assisted	assist	VERB
ct-9922	262	24	genome	genome	NOUN
ct-9922	262	25	editing	editing	NOUN
ct-9922	262	26	in	in	ADP
ct-9922	262	27	japanese	japanese	ADJ
ct-9922	262	28	black	black	ADJ
ct-9922	262	29	cattle	cattle	NOUN
ct-9922	262	30	.	.	PUNCT
ct-9922	263	1	sci	sci	PROPN
ct-9922	263	2	rep	rep	PROPN
ct-9922	263	3	2017;7:17827	2017;7:17827	PROPN
ct-9922	263	4	.	.	PUNCT
ct-9922	264	1	65	65	NUM
ct-9922	264	2	.	.	PUNCT
ct-9922	265	1	zheng	zheng	PROPN
ct-9922	265	2	q	q	PROPN
ct-9922	265	3	,	,	PUNCT
ct-9922	265	4	lin	lin	PROPN
ct-9922	265	5	j	j	PROPN
ct-9922	265	6	,	,	PUNCT
ct-9922	265	7	huang	huang	PROPN
ct-9922	265	8	j	j	PROPN
ct-9922	265	9	,	,	PUNCT
ct-9922	265	10	et	et	PROPN
ct-9922	265	11	al	al	PROPN
ct-9922	265	12	:	:	PUNCT
ct-9922	265	13	reconstitution	reconstitution	NOUN
ct-9922	265	14	of	of	ADP
ct-9922	265	15	ucp1	ucp1	NOUN
ct-9922	265	16	using	use	VERB
ct-9922	265	17	crispr	crispr	PROPN
ct-9922	265	18	/	/	SYM
ct-9922	265	19	cas9	cas9	NOUN
ct-9922	265	20	in	in	ADP
ct-9922	265	21	the	the	DET
ct-9922	265	22	white	white	ADJ
ct-9922	265	23	adipose	adipose	ADJ
ct-9922	265	24	tissue	tissue	NOUN
ct-9922	265	25	of	of	ADP
ct-9922	265	26	pigs	pig	NOUN
ct-9922	265	27	decreases	decrease	VERB
ct-9922	265	28	fat	fat	ADJ
ct-9922	265	29	deposition	deposition	NOUN
ct-9922	265	30	and	and	CCONJ
ct-9922	265	31	improves	improve	VERB
ct-9922	265	32	thermogenic	thermogenic	ADJ
ct-9922	265	33	capacity	capacity	NOUN
ct-9922	265	34	.	.	PUNCT
ct-9922	266	1	proc	proc	NOUN
ct-9922	266	2	nat	nat	PROPN
ct-9922	266	3	acad	acad	PROPN
ct-9922	266	4	sci	sci	PROPN
ct-9922	266	5	2017;114	2017;114	NUM
ct-9922	266	6	:	:	PUNCT
ct-9922	266	7	e9474	e9474	NOUN
ct-9922	266	8	-	-	PUNCT
ct-9922	266	9	e9482	e9482	PROPN
ct-9922	266	10	.	.	PROPN
ct-9922	266	11	66	66	NUM
ct-9922	266	12	.	.	PUNCT
ct-9922	267	1	lee	lee	PROPN
ct-9922	267	2	k	k	PROPN
ct-9922	267	3	,	,	PUNCT
ct-9922	267	4	kwon	kwon	VERB
ct-9922	267	5	dn	dn	PROPN
ct-9922	267	6	,	,	PUNCT
ct-9922	267	7	ezashi	ezashi	PROPN
ct-9922	267	8	t	t	PROPN
ct-9922	267	9	,	,	PUNCT
ct-9922	267	10	et	et	PROPN
ct-9922	267	11	al	al	PROPN
ct-9922	267	12	:	:	PUNCT
ct-9922	267	13	engraftment	engraftment	NOUN
ct-9922	267	14	of	of	ADP
ct-9922	267	15	human	human	ADJ
ct-9922	267	16	ips	ips	NOUN
ct-9922	267	17	cells	cell	NOUN
ct-9922	267	18	and	and	CCONJ
ct-9922	267	19	allogeneic	allogeneic	ADJ
ct-9922	267	20	porcine	porcine	NOUN
ct-9922	267	21	cells	cell	NOUN
ct-9922	267	22	into	into	ADP
ct-9922	267	23	pigs	pig	NOUN
ct-9922	267	24	with	with	ADP
ct-9922	267	25	inactivated	inactivated	ADJ
ct-9922	267	26	rag2	rag2	NOUN
ct-9922	267	27	and	and	CCONJ
ct-9922	267	28	accompanying	accompany	VERB
ct-9922	267	29	severe	severe	ADJ
ct-9922	267	30	combined	combined	ADJ
ct-9922	267	31	immunodeficiency	immunodeficiency	NOUN
ct-9922	267	32	.	.	PUNCT
ct-9922	268	1	proc	proc	NOUN
ct-9922	268	2	nat	nat	PROPN
ct-9922	268	3	acad	acad	PROPN
ct-9922	268	4	sci	sci	PROPN
ct-9922	268	5	2014;111:7260	2014;111:7260	NUM
ct-9922	268	6	-	-	SYM
ct-9922	268	7	7265	7265	NUM
ct-9922	268	8	.	.	PUNCT
ct-9922	268	9	67	67	NUM
ct-9922	268	10	.	.	PUNCT
ct-9922	269	1	kang	kang	PROPN
ct-9922	269	2	jt	jt	PROPN
ct-9922	269	3	,	,	PUNCT
ct-9922	269	4	cho	cho	PROPN
ct-9922	269	5	b	b	PROPN
ct-9922	269	6	,	,	PUNCT
ct-9922	269	7	ryu	ryu	PROPN
ct-9922	269	8	j	j	PROPN
ct-9922	269	9	,	,	PUNCT
ct-9922	269	10	et	et	PROPN
ct-9922	269	11	al	al	PROPN
ct-9922	269	12	:	:	PUNCT
ct-9922	269	13	biallelic	biallelic	ADJ
ct-9922	269	14	modification	modification	NOUN
ct-9922	269	15	of	of	ADP
ct-9922	269	16	il2rg	il2rg	NOUN
ct-9922	269	17	leads	lead	VERB
ct-9922	269	18	to	to	ADP
ct-9922	269	19	severe	severe	ADJ
ct-9922	269	20	combined	combine	VERB
ct-9922	269	21	immunodeficiency	immunodeficiency	NOUN
ct-9922	269	22	in	in	ADP
ct-9922	269	23	pigs	pig	NOUN
ct-9922	269	24	.	.	PUNCT
ct-9922	270	1	reprod	reprod	AUX
ct-9922	270	2	biol	biol	PROPN
ct-9922	270	3	endocrinol	endocrinol	VERB
ct-9922	270	4	2016;14:74	2016;14:74	NUM
ct-9922	270	5	.	.	PUNCT
ct-9922	271	1	68	68	NUM
ct-9922	271	2	.	.	PUNCT
ct-9922	272	1	klymiuk	klymiuk	VERB
ct-9922	272	2	n	n	NUM
ct-9922	272	3	,	,	PUNCT
ct-9922	272	4	blutke	blutke	NOUN
ct-9922	272	5	a	a	X
ct-9922	272	6	,	,	PUNCT
ct-9922	272	7	graf	graf	PROPN
ct-9922	272	8	a	a	X
ct-9922	272	9	,	,	PUNCT
ct-9922	272	10	et	et	PROPN
ct-9922	272	11	al	al	PROPN
ct-9922	272	12	:	:	PUNCT
ct-9922	272	13	dystrophin	dystrophin	ADJ
ct-9922	272	14	-	-	PUNCT
ct-9922	272	15	deficient	deficient	ADJ
ct-9922	272	16	pigs	pig	NOUN
ct-9922	272	17	provide	provide	VERB
ct-9922	272	18	new	new	ADJ
ct-9922	272	19	insights	insight	NOUN
ct-9922	272	20	into	into	ADP
ct-9922	272	21	the	the	DET
ct-9922	272	22	hierarchy	hierarchy	NOUN
ct-9922	272	23	of	of	ADP
ct-9922	272	24	physiological	physiological	ADJ
ct-9922	272	25	derangements	derangement	NOUN
ct-9922	272	26	of	of	ADP
ct-9922	272	27	dystrophic	dystrophic	ADJ
ct-9922	272	28	muscle	muscle	NOUN
ct-9922	272	29	.	.	PUNCT
ct-9922	273	1	hum	hum	PROPN
ct-9922	273	2	mol	mol	ADP
ct-9922	273	3	genet	genet	PROPN
ct-9922	273	4	2013;22:4368	2013;22:4368	NUM
ct-9922	273	5	-	-	SYM
ct-9922	273	6	4382	4382	NUM
ct-9922	273	7	.	.	PUNCT
ct-9922	274	1	69	69	NUM
ct-9922	274	2	.	.	PUNCT
ct-9922	275	1	li	li	PROPN
ct-9922	275	2	p	p	PROPN
ct-9922	275	3	,	,	PUNCT
ct-9922	275	4	estrada	estrada	PROPN
ct-9922	275	5	jl	jl	PROPN
ct-9922	275	6	,	,	PUNCT
ct-9922	275	7	burlak	burlak	ADJ
ct-9922	275	8	c	c	NOUN
ct-9922	275	9	,	,	PUNCT
ct-9922	275	10	et	et	PROPN
ct-9922	275	11	al	al	PROPN
ct-9922	275	12	:	:	PUNCT
ct-9922	275	13	efficient	efficient	ADJ
ct-9922	275	14	generation	generation	NOUN
ct-9922	275	15	of	of	ADP
ct-9922	275	16	genetically	genetically	ADV
ct-9922	275	17	distinct	distinct	ADJ
ct-9922	275	18	pigs	pig	NOUN
ct-9922	275	19	in	in	ADP
ct-9922	275	20	a	a	DET
ct-9922	275	21	single	single	ADJ
ct-9922	275	22	pregnancy	pregnancy	NOUN
ct-9922	275	23	using	use	VERB
ct-9922	275	24	multiplexed	multiplexed	ADJ
ct-9922	275	25	single	single	ADJ
ct-9922	275	26	-	-	PUNCT
ct-9922	275	27	guide	guide	NOUN
ct-9922	275	28	rna	rna	NOUN
ct-9922	275	29	and	and	CCONJ
ct-9922	275	30	carbohydrate	carbohydrate	NOUN
ct-9922	275	31	selection	selection	NOUN
ct-9922	275	32	.	.	PUNCT
ct-9922	276	1	xenotransplantation	xenotransplantation	PROPN
ct-9922	276	2	.	.	PUNCT
ct-9922	277	1	2015;22:20	2015;22:20	NUM
ct-9922	277	2	-	-	SYM
ct-9922	277	3	31	31	NUM
ct-9922	277	4	.	.	PUNCT
ct-9922	278	1	70	70	NUM
ct-9922	278	2	.	.	PUNCT
ct-9922	279	1	ledford	ledford	PROPN
ct-9922	279	2	h	h	PROPN
ct-9922	279	3	:	:	PUNCT
ct-9922	279	4	salmon	salmon	PROPN
ct-9922	279	5	approval	approval	NOUN
ct-9922	279	6	heralds	herald	NOUN
ct-9922	279	7	rethink	rethink	VERB
ct-9922	279	8	of	of	ADP
ct-9922	279	9	transgenic	transgenic	NOUN
ct-9922	279	10	animals	animal	NOUN
ct-9922	279	11	.	.	PUNCT
ct-9922	280	1	nature	nature	NOUN
ct-9922	280	2	2015;527:417	2015;527:417	NUM
ct-9922	280	3	-	-	SYM
ct-9922	280	4	418	418	NUM
ct-9922	280	5	.	.	PUNCT
ct-9922	281	1	clinical	clinical	ADJ
ct-9922	281	2	theriogenology	theriogenology	NOUN
ct-9922	281	3	•	•	NOUN
ct-9922	281	4	volume	volume	NOUN
ct-9922	281	5	10	10	NUM
ct-9922	281	6	,	,	PUNCT
ct-9922	281	7	number	number	NOUN
ct-9922	281	8	3	3	NUM
ct-9922	281	9	•	•	NOUN
ct-9922	281	10	september	september	PROPN
ct-9922	281	11	2018245	2018245	NUM
ct-9922	281	12	clinical	clinical	ADJ
ct-9922	281	13	theriogenology	theriogenology	NOUN
ct-9922	281	14	•	•	NOUN
ct-9922	281	15	volume	volume	NOUN
ct-9922	281	16	10	10	NUM
ct-9922	281	17	,	,	PUNCT
ct-9922	281	18	number	number	NOUN
ct-9922	281	19	3	3	NUM
ct-9922	281	20	•	•	NUM
ct-9922	281	21	september	september	PROPN
ct-9922	281	22	2018	2018	NUM
ct-9922	281	23	246	246	NUM
ct-9922	281	24	omniblank	omniblank	NOUN
ct-9922	281	25	:	:	PUNCT
ct-9922	281	26	<	<	X
ct-9922	281	27	<	<	X
ct-9922	281	28	/ascii85encodepages	/ascii85encodepage	NOUN
ct-9922	281	29	false	false	ADJ
ct-9922	281	30	/allowtransparency	/allowtransparency	NOUN
ct-9922	281	31	false	false	ADJ
ct-9922	281	32	/autopositionepsfiles	/autopositionepsfile	NOUN
ct-9922	281	33	true	true	ADJ
ct-9922	281	34	/autorotatepages	/autorotatepage	NOUN
ct-9922	281	35	/none	/none	PUNCT
ct-9922	281	36	/binding	/binding	PUNCT
ct-9922	281	37	/left	/left	ADJ
ct-9922	282	1	/calgrayprofile	/calgrayprofile	VERB
ct-9922	282	2	(	(	PUNCT
ct-9922	282	3	dot	dot	NOUN
ct-9922	282	4	gain	gain	NOUN
ct-9922	282	5	20	20	NUM
ct-9922	282	6	%	%	NOUN
ct-9922	282	7	)	)	PUNCT
ct-9922	282	8	/calrgbprofile	/calrgbprofile	PUNCT
ct-9922	283	1	(	(	PUNCT
ct-9922	283	2	srgb	srgb	PROPN
ct-9922	283	3	iec61966	iec61966	NOUN
ct-9922	283	4	-	-	PUNCT
ct-9922	283	5	2.1	2.1	NUM
ct-9922	283	6	)	)	PUNCT
ct-9922	283	7	/calcmykprofile	/calcmykprofile	PUNCT
ct-9922	284	1	(	(	PUNCT
ct-9922	284	2	u.s	u.s	PROPN
ct-9922	284	3	.	.	PROPN
ct-9922	284	4	web	web	NOUN
ct-9922	284	5	coated	coat	VERB
ct-9922	284	6	\050swop\051	\050swop\051	ADJ
ct-9922	284	7	v2	v2	NOUN
ct-9922	284	8	)	)	PUNCT
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ct-9922	284	10	(	(	PUNCT
ct-9922	284	11	srgb	srgb	PROPN
ct-9922	284	12	iec61966	iec61966	NOUN
ct-9922	284	13	-	-	PUNCT
ct-9922	284	14	2.1	2.1	NUM
ct-9922	284	15	)	)	PUNCT
ct-9922	284	16	/cannotembedfontpolicy	/cannotembedfontpolicy	NOUN
ct-9922	285	1	/warning	/warne	VERB
ct-9922	285	2	/compatibilitylevel	/compatibilitylevel	NOUN
ct-9922	285	3	1.6	1.6	NUM
ct-9922	285	4	/compressobjects	/compressobject	NOUN
ct-9922	286	1	/tags	/tag	VERB
ct-9922	286	2	/compresspages	/compresspage	NOUN
ct-9922	286	3	true	true	ADJ
ct-9922	286	4	/convertimagestoindexed	/convertimagestoindexed	ADJ
ct-9922	286	5	true	true	ADJ
ct-9922	286	6	/passthroughjpegimages	/passthroughjpegimage	NOUN
ct-9922	286	7	true	true	ADJ
ct-9922	286	8	/createjobticket	/createjobticket	NOUN
ct-9922	286	9	false	false	ADJ
ct-9922	286	10	/defaultrenderingintent	/defaultrenderingintent	NOUN
ct-9922	286	11	/default	/default	PUNCT
ct-9922	286	12	/detectblends	/detectblend	NOUN
ct-9922	286	13	true	true	ADJ
ct-9922	286	14	/detectcurves	/detectcurve	NOUN
ct-9922	286	15	0.0000	0.0000	NUM
ct-9922	286	16	/colorconversionstrategy	/colorconversionstrategy	NOUN
ct-9922	286	17	/leavecolorunchanged	/leavecolorunchange	VERB
ct-9922	286	18	/dothumbnails	/dothumbnail	VERB
ct-9922	287	1	false	false	ADJ
ct-9922	287	2	/embedallfonts	/embedallfont	NOUN
ct-9922	287	3	true	true	ADJ
ct-9922	287	4	/embedopentype	/embedopentype	PUNCT
ct-9922	287	5	true	true	ADJ
ct-9922	287	6	/parseiccprofilesincomments	/parseiccprofilesincomment	NOUN
ct-9922	287	7	true	true	ADJ
ct-9922	287	8	/embedjoboptions	/embedjoboption	NOUN
ct-9922	287	9	true	true	ADJ
ct-9922	287	10	/dscreportinglevel	/dscreportinglevel	NOUN
ct-9922	287	11	0	0	NUM
ct-9922	287	12	/emitdscwarnings	/emitdscwarning	NOUN
ct-9922	287	13	false	false	ADJ
ct-9922	287	14	/endpage	/endpage	NOUN
ct-9922	287	15	-1	-1	NOUN
ct-9922	287	16	/imagememory	/imagememory	NUM
ct-9922	287	17	1048576	1048576	NUM
ct-9922	287	18	/lockdistillerparams	/lockdistillerparams	NOUN
ct-9922	287	19	false	false	ADJ
ct-9922	287	20	/maxsubsetpct	/maxsubsetpct	ADJ
ct-9922	287	21	100	100	NUM
ct-9922	287	22	/optimize	/optimize	NOUN
ct-9922	287	23	true	true	ADJ
ct-9922	287	24	/opm	/opm	NOUN
ct-9922	287	25	1	1	NUM
ct-9922	287	26	/parsedsccomments	/parsedsccomment	NOUN
ct-9922	287	27	true	true	ADJ
ct-9922	287	28	/parsedsccommentsfordocinfo	/parsedsccommentsfordocinfo	VERB
ct-9922	287	29	true	true	ADJ
ct-9922	287	30	/preservecopypage	/preservecopypage	NOUN
ct-9922	287	31	true	true	ADJ
ct-9922	287	32	/preservedicmykvalues	/preservedicmykvalue	NOUN
ct-9922	287	33	true	true	ADJ
ct-9922	287	34	/preserveepsinfo	/preserveepsinfo	NOUN
ct-9922	287	35	true	true	ADJ
ct-9922	287	36	/preserveflatness	/preserveflatness	NOUN
ct-9922	287	37	true	true	ADJ
ct-9922	287	38	/preservehalftoneinfo	/preservehalftoneinfo	PUNCT
ct-9922	287	39	false	false	ADJ
ct-9922	287	40	/preserveopicomments	/preserveopicomment	NOUN
ct-9922	287	41	true	true	ADJ
ct-9922	287	42	/preserveoverprintsettings	/preserveoverprintsetting	NOUN
ct-9922	287	43	true	true	ADJ
ct-9922	287	44	/startpage	/startpage	NOUN
ct-9922	287	45	1	1	NUM
ct-9922	287	46	/subsetfonts	/subsetfont	NOUN
ct-9922	287	47	true	true	ADJ
ct-9922	287	48	/transferfunctioninfo	/transferfunctioninfo	PUNCT
ct-9922	287	49	/apply	/apply	PUNCT
ct-9922	287	50	/ucrandbginfo	/ucrandbginfo	PUNCT
ct-9922	288	1	/preserve	/preserve	NOUN
ct-9922	288	2	/useprologue	/useprologue	NOUN
ct-9922	288	3	false	false	ADJ
ct-9922	288	4	/colorsettingsfile	/colorsettingsfile	NOUN
ct-9922	288	5	(	(	PUNCT
ct-9922	288	6	)	)	PUNCT
ct-9922	288	7	/alwaysembed	/alwaysembe	VERB
ct-9922	288	8	[	[	PUNCT
ct-9922	288	9	true	true	ADJ
ct-9922	288	10	]	]	PUNCT
ct-9922	288	11	/neverembed	/neverembed	PUNCT
ct-9922	289	1	[	[	PUNCT
ct-9922	289	2	true	true	ADJ
ct-9922	289	3	]	]	PUNCT
ct-9922	289	4	/antialiascolorimages	/antialiascolorimages	X
ct-9922	289	5	false	false	ADJ
ct-9922	289	6	/cropcolorimages	/cropcolorimages	PUNCT
ct-9922	289	7	true	true	ADJ
ct-9922	289	8	/colorimageminresolution	/colorimageminresolution	PUNCT
ct-9922	289	9	300	300	NUM
ct-9922	289	10	/colorimageminresolutionpolicy	/colorimageminresolutionpolicy	NOUN
ct-9922	289	11	/ok	/ok	ADJ
ct-9922	290	1	/downsamplecolorimages	/downsamplecolorimage	VERB
ct-9922	291	1	true	true	ADJ
ct-9922	291	2	/colorimagedownsampletype	/colorimagedownsampletype	PUNCT
ct-9922	291	3	/bicubic	/bicubic	NOUN
ct-9922	291	4	/colorimageresolution	/colorimageresolution	NOUN
ct-9922	292	1	300	300	NUM
ct-9922	292	2	/colorimagedepth	/colorimagedepth	PRON
ct-9922	292	3	-1	-1	INTJ
ct-9922	292	4	/colorimagemindownsampledepth	/colorimagemindownsampledepth	SYM
ct-9922	292	5	1	1	NUM
ct-9922	292	6	/colorimagedownsamplethreshold	/colorimagedownsamplethreshold	SYM
ct-9922	292	7	1.50000	1.50000	NUM
ct-9922	292	8	/encodecolorimages	/encodecolorimage	NOUN
ct-9922	292	9	true	true	ADJ
ct-9922	292	10	/colorimagefilter	/colorimagefilter	PUNCT
ct-9922	292	11	/dctencode	/dctencode	PUNCT
ct-9922	293	1	/autofiltercolorimages	/autofiltercolorimage	NOUN
ct-9922	293	2	true	true	ADJ
ct-9922	293	3	/colorimageautofilterstrategy	/colorimageautofilterstrategy	PUNCT
ct-9922	293	4	/jpeg	/jpeg	PUNCT
ct-9922	293	5	/coloracsimagedict	/coloracsimagedict	PUNCT
ct-9922	294	1	<	<	X
ct-9922	294	2	<	<	X
ct-9922	294	3	/qfactor	/qfactor	NOUN
ct-9922	294	4	0.15	0.15	NUM
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ct-9922	295	1	[	[	X
ct-9922	295	2	1	1	NUM
ct-9922	295	3	1	1	NUM
ct-9922	295	4	1	1	NUM
ct-9922	295	5	1	1	NUM
ct-9922	295	6	]	]	PUNCT
ct-9922	295	7	/vsamples	/vsample	NOUN
ct-9922	296	1	[	[	X
ct-9922	296	2	1	1	NUM
ct-9922	296	3	1	1	NUM
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ct-9922	296	5	1	1	NUM
ct-9922	296	6	]	]	PUNCT
ct-9922	296	7	>	>	PUNCT
ct-9922	296	8	>	>	X
ct-9922	296	9	/colorimagedict	/colorimagedict	PUNCT
ct-9922	297	1	<	<	X
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ct-9922	299	8	>	>	X
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ct-9922	302	4	/encodegrayimages	/encodegrayimage	NOUN
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ct-9922	303	4	/jpeg	/jpeg	PUNCT
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ct-9922	305	6	]	]	PUNCT
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ct-9922	316	7	(	(	PUNCT
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ct-9922	336	3	>	>	X
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ct-9922	348	9	false	false	ADJ
ct-9922	348	10	/namespace	/namespace	NOUN
ct-9922	349	1	[	[	PUNCT
ct-9922	349	2	(	(	PUNCT
ct-9922	349	3	adobe	adobe	PROPN
ct-9922	349	4	)	)	PUNCT
ct-9922	349	5	(	(	PUNCT
ct-9922	349	6	indesign	indesign	NOUN
ct-9922	349	7	)	)	PUNCT
ct-9922	349	8	(	(	PUNCT
ct-9922	349	9	4.0	4.0	NUM
ct-9922	349	10	)	)	PUNCT
ct-9922	349	11	]	]	PUNCT
ct-9922	349	12	/omitplacedbitmaps	/omitplacedbitmaps	PUNCT
ct-9922	350	1	false	false	ADJ
ct-9922	350	2	/omitplacedeps	/omitplacedeps	INTJ
ct-9922	350	3	false	false	ADJ
ct-9922	350	4	/omitplacedpdf	/omitplacedpdf	PUNCT
ct-9922	350	5	false	false	ADJ
ct-9922	350	6	/simulateoverprint	/simulateoverprint	NOUN
ct-9922	350	7	/legacy	/legacy	PUNCT
ct-9922	351	1	>	>	PUNCT
ct-9922	351	2	>	>	X
ct-9922	352	1	<	<	X
ct-9922	352	2	<	<	X
ct-9922	352	3	/addbleedmarks	/addbleedmarks	X
ct-9922	352	4	false	false	ADJ
ct-9922	352	5	/addcolorbars	/addcolorbars	INTJ
ct-9922	352	6	false	false	ADJ
ct-9922	352	7	/addcropmarks	/addcropmarks	PUNCT
ct-9922	352	8	false	false	ADJ
ct-9922	352	9	/addpageinfo	/addpageinfo	INTJ
ct-9922	352	10	false	false	ADJ
ct-9922	352	11	/addregmarks	/addregmark	NOUN
ct-9922	352	12	false	false	ADJ
ct-9922	352	13	/convertcolors	/convertcolor	NOUN
ct-9922	352	14	/converttocmyk	/converttocmyk	INTJ
ct-9922	352	15	/destinationprofilename	/destinationprofilename	PUNCT
ct-9922	352	16	(	(	PUNCT
ct-9922	352	17	)	)	PUNCT
ct-9922	352	18	/destinationprofileselector	/destinationprofileselector	NOUN
ct-9922	352	19	/documentcmyk	/documentcmyk	PUNCT
ct-9922	352	20	/downsample16bitimages	/downsample16bitimage	NOUN
ct-9922	352	21	true	true	ADJ
ct-9922	352	22	/flattenerpreset	/flattenerpreset	PUNCT
ct-9922	353	1	<	<	X
ct-9922	353	2	<	<	X
ct-9922	353	3	/presetselector	/presetselector	X
ct-9922	353	4	/mediumresolution	/mediumresolution	NOUN
ct-9922	353	5	>	>	PUNCT
ct-9922	353	6	>	>	X
ct-9922	353	7	/formelements	/formelement	NOUN
ct-9922	354	1	false	false	ADJ
ct-9922	354	2	/generatestructure	/generatestructure	PUNCT
ct-9922	354	3	false	false	ADJ
ct-9922	354	4	/includebookmarks	/includebookmark	NOUN
ct-9922	354	5	false	false	ADJ
ct-9922	354	6	/includehyperlinks	/includehyperlinks	INTJ
ct-9922	354	7	false	false	ADJ
ct-9922	354	8	/includeinteractive	/includeinteractive	ADJ
ct-9922	354	9	false	false	ADJ
ct-9922	354	10	/includelayers	/includelayer	NOUN
ct-9922	354	11	false	false	ADJ
ct-9922	354	12	/includeprofiles	/includeprofiles	INTJ
ct-9922	354	13	false	false	ADJ
ct-9922	354	14	/multimediahandling	/multimediahandling	NOUN
ct-9922	355	1	/useobjectsettings	/useobjectsettings	PRON
ct-9922	356	1	/namespace	/namespace	PUNCT
ct-9922	357	1	[	[	PUNCT
ct-9922	357	2	(	(	PUNCT
ct-9922	357	3	adobe	adobe	PROPN
ct-9922	357	4	)	)	PUNCT
ct-9922	357	5	(	(	PUNCT
ct-9922	357	6	creativesuite	creativesuite	NOUN
ct-9922	357	7	)	)	PUNCT
ct-9922	357	8	(	(	PUNCT
ct-9922	357	9	2.0	2.0	NUM
ct-9922	357	10	)	)	PUNCT
ct-9922	357	11	]	]	PUNCT
ct-9922	358	1	/pdfxoutputintentprofileselector	/pdfxoutputintentprofileselector	INTJ
ct-9922	358	2	/documentcmyk	/documentcmyk	PUNCT
ct-9922	359	1	/preserveediting	/preserveedite	VERB
ct-9922	359	2	true	true	ADJ
ct-9922	359	3	/untaggedcmykhandling	/untaggedcmykhandling	NOUN
ct-9922	359	4	/leaveuntagged	/leaveuntagge	VERB
ct-9922	359	5	/untaggedrgbhandling	/untaggedrgbhandling	NOUN
ct-9922	359	6	/usedocumentprofile	/usedocumentprofile	INTJ
ct-9922	359	7	/usedocumentbleed	/usedocumentbleed	NOUN
ct-9922	360	1	false	false	ADJ
ct-9922	360	2	>	>	PUNCT
ct-9922	360	3	>	>	X
ct-9922	360	4	]	]	PUNCT
ct-9922	360	5	>	>	PUNCT
ct-9922	360	6	>	>	X
ct-9922	360	7	setdistillerparams	setdistillerparam	NOUN
ct-9922	361	1	<	<	X
ct-9922	361	2	<	<	X
ct-9922	361	3	/hwresolution	/hwresolution	NOUN
ct-9922	362	1	[	[	X
ct-9922	362	2	2400	2400	NUM
ct-9922	362	3	2400	2400	NUM
ct-9922	362	4	]	]	PUNCT
ct-9922	362	5	/pagesize	/pagesize	X
ct-9922	363	1	[	[	X
ct-9922	363	2	612.000	612.000	NUM
ct-9922	363	3	792.000	792.000	NUM
ct-9922	363	4	]	]	PUNCT
ct-9922	363	5	>	>	PUNCT
ct-9922	363	6	>	>	X
ct-9922	363	7	setpagedevice	setpagedevice	PROPN