id	author	title	date	pages	extension	mime	words	sentence	flesch	summary	cache	txt
cusj-5696	Obradovic, Aleksandar; Qi, Hongjian	CFHMM: Heterogeneous Tumor CNV Classification by Hidden Markov	2020	2	.pdf	application/pdf	1616	68	46	After 15-state classification, a posterior purity estimate for each bin where tumor state is not equal to normal state can be derived from equation 2, and this distribution can be plotted to visualize clonal fraction, as well as k-means-clustered to group mutations belonging to the same clone sub-population. Where, conversely: (2) The purity prior k for input into CFHMM is taken as the mean of values from equation 2, assuming normal state 2 and using only extreme log-ratios over the equation 1 values for pure (k=1) tumor state 3, or under the threshold for pure tumor state 1.	cache/cusj-5696.pdf	txt/cusj-5696.txt