id	sid	tid	token	lemma	pos
cusj-10288	1	1	template	template	NOUN
cusj-10288	1	2	for	for	ADP
cusj-10288	1	3	electronic	electronic	ADJ
cusj-10288	1	4	submission	submission	NOUN
cusj-10288	1	5	to	to	ADP
cusj-10288	1	6	acs	acs	PROPN
cusj-10288	1	7	journals	journal	NOUN
cusj-10288	1	8	17	17	NUM
cusj-10288	1	9	©	©	PROPN
cusj-10288	1	10	2023	2023	NUM
cusj-10288	1	11	datta	datta	PROPN
cusj-10288	1	12	,	,	PUNCT
cusj-10288	1	13	neelabh	neelabh	PROPN
cusj-10288	1	14	.	.	PUNCT
cusj-10288	2	1	this	this	PRON
cusj-10288	2	2	is	be	AUX
cusj-10288	2	3	an	an	DET
cusj-10288	2	4	open	open	ADJ
cusj-10288	2	5	access	access	NOUN
cusj-10288	2	6	article	article	NOUN
cusj-10288	2	7	distributed	distribute	VERB
cusj-10288	2	8	under	under	ADP
cusj-10288	2	9	the	the	DET
cusj-10288	2	10	terms	term	NOUN
cusj-10288	2	11	of	of	ADP
cusj-10288	2	12	the	the	DET
cusj-10288	2	13	creative	creative	ADJ
cusj-10288	2	14	commons	common	NOUN
cusj-10288	2	15	attribution	attribution	NOUN
cusj-10288	2	16	license	license	NOUN
cusj-10288	2	17	,	,	PUNCT
cusj-10288	2	18	which	which	PRON
cusj-10288	2	19	permits	permit	VERB
cusj-10288	2	20	the	the	DET
cusj-10288	2	21	user	user	NOUN
cusj-10288	2	22	to	to	PART
cusj-10288	2	23	copy	copy	VERB
cusj-10288	2	24	,	,	PUNCT
cusj-10288	2	25	distribute	distribute	VERB
cusj-10288	2	26	,	,	PUNCT
cusj-10288	2	27	and	and	CCONJ
cusj-10288	2	28	transmit	transmit	VERB
cusj-10288	2	29	the	the	DET
cusj-10288	2	30	work	work	NOUN
cusj-10288	2	31	provided	provide	VERB
cusj-10288	2	32	that	that	SCONJ
cusj-10288	2	33	the	the	DET
cusj-10288	2	34	original	original	ADJ
cusj-10288	2	35	authors	author	NOUN
cusj-10288	2	36	and	and	CCONJ
cusj-10288	2	37	source	source	NOUN
cusj-10288	2	38	are	be	AUX
cusj-10288	2	39	credited	credit	VERB
cusj-10288	2	40	.	.	PUNCT
cusj-10288	3	1	molecular	molecular	ADJ
cusj-10288	3	2	mechanisms	mechanism	NOUN
cusj-10288	3	3	and	and	CCONJ
cusj-10288	3	4	clinical	clinical	ADJ
cusj-10288	3	5	features	feature	NOUN
cusj-10288	3	6	of	of	ADP
cusj-10288	3	7	huntington	huntington	PROPN
cusj-10288	3	8	disease	disease	PROPN
cusj-10288	3	9	:	:	PUNCT
cusj-10288	3	10	a	a	DET
cusj-10288	3	11	fatal	fatal	ADJ
cusj-10288	3	12	neurodegenerative	neurodegenerative	ADJ
cusj-10288	3	13	disorder	disorder	NOUN
cusj-10288	3	14	with	with	ADP
cusj-10288	3	15	autosomal	autosomal	ADJ
cusj-10288	3	16	dominant	dominant	ADJ
cusj-10288	3	17	inheritance	inheritance	NOUN
cusj-10288	3	18	neelabh	neelabh	NOUN
cusj-10288	3	19	datta1	datta1	PROPN
cusj-10288	3	20	1department	1department	NUM
cusj-10288	3	21	of	of	ADP
cusj-10288	3	22	biochemistry	biochemistry	NOUN
cusj-10288	3	23	,	,	PUNCT
cusj-10288	3	24	asutosh	asutosh	PROPN
cusj-10288	3	25	college	college	PROPN
cusj-10288	3	26	(	(	PUNCT
cusj-10288	3	27	affiliated	affiliate	VERB
cusj-10288	3	28	to	to	ADP
cusj-10288	3	29	university	university	NOUN
cusj-10288	3	30	of	of	ADP
cusj-10288	3	31	calcutta	calcutta	PROPN
cusj-10288	3	32	)	)	PUNCT
cusj-10288	3	33	,	,	PUNCT
cusj-10288	3	34	92	92	NUM
cusj-10288	3	35	,	,	PUNCT
cusj-10288	3	36	shyama	shyama	NOUN
cusj-10288	3	37	prasad	prasad	PROPN
cusj-10288	3	38	mukherjee	mukherjee	PROPN
cusj-10288	3	39	rd	rd	PROPN
cusj-10288	3	40	,	,	PUNCT
cusj-10288	3	41	kolkata	kolkata	PROPN
cusj-10288	3	42	,	,	PUNCT
cusj-10288	3	43	west	west	PROPN
cusj-10288	3	44	bengal	bengal	PROPN
cusj-10288	3	45	,	,	PUNCT
cusj-10288	3	46	700025	700025	NUM
cusj-10288	3	47	,	,	PUNCT
cusj-10288	3	48	india	india	PROPN
cusj-10288	3	49	keywords	keyword	NOUN
cusj-10288	3	50	:	:	PUNCT
cusj-10288	3	51	huntington	huntington	PROPN
cusj-10288	3	52	’s	’s	PART
cusj-10288	3	53	disease	disease	NOUN
cusj-10288	3	54	,	,	PUNCT
cusj-10288	3	55	neurogenetics	neurogenetic	NOUN
cusj-10288	3	56	,	,	PUNCT
cusj-10288	3	57	molecular	molecular	ADJ
cusj-10288	3	58	mechanisms	mechanism	NOUN
cusj-10288	3	59	,	,	PUNCT
cusj-10288	3	60	pathophysiology	pathophysiology	NOUN
cusj-10288	3	61	,	,	PUNCT
cusj-10288	3	62	therapy	therapy	NOUN
cusj-10288	3	63	abstract	abstract	NOUN
cusj-10288	3	64	:	:	PUNCT
cusj-10288	3	65	huntington	huntington	PROPN
cusj-10288	3	66	disease	disease	PROPN
cusj-10288	3	67	(	(	PUNCT
cusj-10288	3	68	hd	hd	NOUN
cusj-10288	3	69	)	)	PUNCT
cusj-10288	3	70	is	be	AUX
cusj-10288	3	71	a	a	DET
cusj-10288	3	72	fatal	fatal	ADJ
cusj-10288	3	73	genetic	genetic	ADJ
cusj-10288	3	74	disorder	disorder	NOUN
cusj-10288	3	75	that	that	PRON
cusj-10288	3	76	affects	affect	VERB
cusj-10288	3	77	the	the	DET
cusj-10288	3	78	movement	movement	NOUN
cusj-10288	3	79	and	and	CCONJ
cusj-10288	3	80	cognition	cognition	NOUN
cusj-10288	3	81	of	of	ADP
cusj-10288	3	82	affected	affected	ADJ
cusj-10288	3	83	individuals	individual	NOUN
cusj-10288	3	84	.	.	PUNCT
cusj-10288	4	1	it	it	PRON
cusj-10288	4	2	is	be	AUX
cusj-10288	4	3	inherited	inherit	VERB
cusj-10288	4	4	in	in	ADP
cusj-10288	4	5	an	an	DET
cusj-10288	4	6	autosomal	autosomal	ADJ
cusj-10288	4	7	dominant	dominant	ADJ
cusj-10288	4	8	manner	manner	NOUN
cusj-10288	4	9	,	,	PUNCT
cusj-10288	4	10	meaning	mean	VERB
cusj-10288	4	11	that	that	SCONJ
cusj-10288	4	12	each	each	DET
cusj-10288	4	13	child	child	NOUN
cusj-10288	4	14	of	of	ADP
cusj-10288	4	15	a	a	DET
cusj-10288	4	16	parent	parent	NOUN
cusj-10288	4	17	with	with	ADP
cusj-10288	4	18	hd	hd	PROPN
cusj-10288	4	19	has	have	VERB
cusj-10288	4	20	a	a	DET
cusj-10288	4	21	50	50	NUM
cusj-10288	4	22	%	%	NOUN
cusj-10288	4	23	chance	chance	NOUN
cusj-10288	4	24	of	of	ADP
cusj-10288	4	25	inheriting	inherit	VERB
cusj-10288	4	26	the	the	DET
cusj-10288	4	27	mutated	mutate	VERB
cusj-10288	4	28	gene	gene	NOUN
cusj-10288	4	29	.	.	PUNCT
cusj-10288	5	1	the	the	DET
cusj-10288	5	2	mutation	mutation	NOUN
cusj-10288	5	3	involves	involve	VERB
cusj-10288	5	4	an	an	DET
cusj-10288	5	5	expansion	expansion	NOUN
cusj-10288	5	6	of	of	ADP
cusj-10288	5	7	a	a	DET
cusj-10288	5	8	trinucleotide	trinucleotide	NOUN
cusj-10288	5	9	repeat	repeat	NOUN
cusj-10288	5	10	(	(	PUNCT
cusj-10288	5	11	cag	cag	PROPN
cusj-10288	5	12	)	)	PUNCT
cusj-10288	5	13	in	in	ADP
cusj-10288	5	14	the	the	DET
cusj-10288	5	15	hd	hd	NOUN
cusj-10288	5	16	gene	gene	NOUN
cusj-10288	5	17	,	,	PUNCT
cusj-10288	5	18	which	which	PRON
cusj-10288	5	19	is	be	AUX
cusj-10288	5	20	located	locate	VERB
cusj-10288	5	21	on	on	ADP
cusj-10288	5	22	the	the	DET
cusj-10288	5	23	short	short	ADJ
cusj-10288	5	24	arm	arm	NOUN
cusj-10288	5	25	of	of	ADP
cusj-10288	5	26	chromosome	chromosome	NOUN
cusj-10288	5	27	4p16.3	4p16.3	NOUN
cusj-10288	5	28	.	.	PUNCT
cusj-10288	6	1	the	the	DET
cusj-10288	6	2	hd	hd	NOUN
cusj-10288	6	3	gene	gene	NOUN
cusj-10288	6	4	encodes	encode	VERB
cusj-10288	6	5	a	a	DET
cusj-10288	6	6	protein	protein	NOUN
cusj-10288	6	7	called	call	VERB
cusj-10288	6	8	huntingtin	huntingtin	NOUN
cusj-10288	6	9	,	,	PUNCT
cusj-10288	6	10	which	which	PRON
cusj-10288	6	11	has	have	VERB
cusj-10288	6	12	an	an	DET
cusj-10288	6	13	unknown	unknown	ADJ
cusj-10288	6	14	function	function	NOUN
cusj-10288	6	15	.	.	PUNCT
cusj-10288	7	1	the	the	DET
cusj-10288	7	2	number	number	NOUN
cusj-10288	7	3	of	of	ADP
cusj-10288	7	4	cag	cag	PROPN
cusj-10288	7	5	repeats	repeat	NOUN
cusj-10288	7	6	determines	determine	VERB
cusj-10288	7	7	the	the	DET
cusj-10288	7	8	severity	severity	NOUN
cusj-10288	7	9	and	and	CCONJ
cusj-10288	7	10	onset	onset	NOUN
cusj-10288	7	11	of	of	ADP
cusj-10288	7	12	the	the	DET
cusj-10288	7	13	disease	disease	NOUN
cusj-10288	7	14	.	.	PUNCT
cusj-10288	8	1	normal	normal	ADJ
cusj-10288	8	2	individuals	individual	NOUN
cusj-10288	8	3	have	have	VERB
cusj-10288	8	4	26	26	NUM
cusj-10288	8	5	or	or	CCONJ
cusj-10288	8	6	fewer	few	ADJ
cusj-10288	8	7	repeats	repeat	NOUN
cusj-10288	8	8	,	,	PUNCT
cusj-10288	8	9	while	while	SCONJ
cusj-10288	8	10	hd	hd	NOUN
cusj-10288	8	11	patients	patient	NOUN
cusj-10288	8	12	have	have	VERB
cusj-10288	8	13	40	40	NUM
cusj-10288	8	14	or	or	CCONJ
cusj-10288	8	15	more	more	ADJ
cusj-10288	8	16	repeats	repeat	NOUN
cusj-10288	8	17	.	.	PUNCT
cusj-10288	9	1	individuals	individual	NOUN
cusj-10288	9	2	with	with	ADP
cusj-10288	9	3	27	27	NUM
cusj-10288	9	4	to	to	PART
cusj-10288	9	5	35	35	NUM
cusj-10288	9	6	repeats	repeat	NOUN
cusj-10288	9	7	do	do	AUX
cusj-10288	9	8	not	not	PART
cusj-10288	9	9	develop	develop	VERB
cusj-10288	9	10	hd	hd	NOUN
cusj-10288	9	11	,	,	PUNCT
cusj-10288	9	12	but	but	CCONJ
cusj-10288	9	13	they	they	PRON
cusj-10288	9	14	can	can	AUX
cusj-10288	9	15	pass	pass	VERB
cusj-10288	9	16	on	on	ADP
cusj-10288	9	17	the	the	DET
cusj-10288	9	18	mutation	mutation	NOUN
cusj-10288	9	19	to	to	ADP
cusj-10288	9	20	their	their	PRON
cusj-10288	9	21	offspring	offspring	NOUN
cusj-10288	9	22	,	,	PUNCT
cusj-10288	9	23	especially	especially	ADV
cusj-10288	9	24	if	if	SCONJ
cusj-10288	9	25	the	the	DET
cusj-10288	9	26	mutation	mutation	NOUN
cusj-10288	9	27	is	be	AUX
cusj-10288	9	28	inherited	inherit	VERB
cusj-10288	9	29	from	from	ADP
cusj-10288	9	30	the	the	DET
cusj-10288	9	31	father	father	NOUN
cusj-10288	9	32	.	.	PUNCT
cusj-10288	10	1	individuals	individual	NOUN
cusj-10288	10	2	with	with	ADP
cusj-10288	10	3	36	36	NUM
cusj-10288	10	4	to	to	PART
cusj-10288	10	5	39	39	NUM
cusj-10288	10	6	repeats	repeat	NOUN
cusj-10288	10	7	may	may	AUX
cusj-10288	10	8	or	or	CCONJ
cusj-10288	10	9	may	may	AUX
cusj-10288	10	10	not	not	PART
cusj-10288	10	11	develop	develop	VERB
cusj-10288	10	12	hd	hd	NOUN
cusj-10288	10	13	,	,	PUNCT
cusj-10288	10	14	depending	depend	VERB
cusj-10288	10	15	on	on	ADP
cusj-10288	10	16	other	other	ADJ
cusj-10288	10	17	factors	factor	NOUN
cusj-10288	10	18	.	.	PUNCT
cusj-10288	11	1	the	the	PRON
cusj-10288	11	2	more	more	ADJ
cusj-10288	11	3	cag	cag	PROPN
cusj-10288	11	4	repeats	repeat	NOUN
cusj-10288	11	5	,	,	PUNCT
cusj-10288	11	6	the	the	PRON
cusj-10288	11	7	earlier	early	ADJ
cusj-10288	11	8	the	the	DET
cusj-10288	11	9	symptoms	symptom	NOUN
cusj-10288	11	10	appear	appear	VERB
cusj-10288	11	11	.	.	PUNCT
cusj-10288	12	1	hd	hd	PROPN
cusj-10288	12	2	is	be	AUX
cusj-10288	12	3	the	the	DET
cusj-10288	12	4	most	most	ADV
cusj-10288	12	5	extensively	extensively	ADV
cusj-10288	12	6	studied	study	VERB
cusj-10288	12	7	neurodegenerative	neurodegenerative	ADJ
cusj-10288	12	8	disorder	disorder	NOUN
cusj-10288	12	9	with	with	ADP
cusj-10288	12	10	a	a	DET
cusj-10288	12	11	genetic	genetic	ADJ
cusj-10288	12	12	cause	cause	NOUN
cusj-10288	12	13	.	.	PUNCT
cusj-10288	13	1	there	there	PRON
cusj-10288	13	2	are	be	VERB
cusj-10288	13	3	genetic	genetic	ADJ
cusj-10288	13	4	tests	test	NOUN
cusj-10288	13	5	available	available	ADJ
cusj-10288	13	6	to	to	PART
cusj-10288	13	7	diagnose	diagnose	VERB
cusj-10288	13	8	hd	hd	NOUN
cusj-10288	13	9	and	and	CCONJ
cusj-10288	13	10	to	to	PART
cusj-10288	13	11	predict	predict	VERB
cusj-10288	13	12	the	the	DET
cusj-10288	13	13	risk	risk	NOUN
cusj-10288	13	14	of	of	ADP
cusj-10288	13	15	developing	develop	VERB
cusj-10288	13	16	hd	hd	NOUN
cusj-10288	13	17	in	in	ADP
cusj-10288	13	18	asymptomatic	asymptomatic	ADJ
cusj-10288	13	19	individuals	individual	NOUN
cusj-10288	13	20	.	.	PUNCT
cusj-10288	14	1	there	there	PRON
cusj-10288	14	2	are	be	VERB
cusj-10288	14	3	also	also	ADV
cusj-10288	14	4	prenatal	prenatal	ADJ
cusj-10288	14	5	and	and	CCONJ
cusj-10288	14	6	preimplantation	preimplantation	NOUN
cusj-10288	14	7	tests	test	NOUN
cusj-10288	14	8	to	to	PART
cusj-10288	14	9	prevent	prevent	VERB
cusj-10288	14	10	the	the	DET
cusj-10288	14	11	transmission	transmission	NOUN
cusj-10288	14	12	of	of	ADP
cusj-10288	14	13	hd	hd	NOUN
cusj-10288	14	14	to	to	ADP
cusj-10288	14	15	the	the	DET
cusj-10288	14	16	next	next	ADJ
cusj-10288	14	17	generation	generation	NOUN
cusj-10288	14	18	.	.	PUNCT
cusj-10288	15	1	hd	hd	PROPN
cusj-10288	15	2	is	be	AUX
cusj-10288	15	3	characterized	characterize	VERB
cusj-10288	15	4	by	by	ADP
cusj-10288	15	5	involuntary	involuntary	ADJ
cusj-10288	15	6	movements	movement	NOUN
cusj-10288	15	7	called	call	VERB
cusj-10288	15	8	chorea	chorea	NOUN
cusj-10288	15	9	,	,	PUNCT
cusj-10288	15	10	which	which	PRON
cusj-10288	15	11	affect	affect	VERB
cusj-10288	15	12	all	all	DET
cusj-10288	15	13	muscles	muscle	NOUN
cusj-10288	15	14	and	and	CCONJ
cusj-10288	15	15	impair	impair	VERB
cusj-10288	15	16	all	all	DET
cusj-10288	15	17	psychomotor	psychomotor	NOUN
cusj-10288	15	18	functions	function	NOUN
cusj-10288	15	19	.	.	PUNCT
cusj-10288	16	1	hd	hd	NOUN
cusj-10288	16	2	patients	patient	NOUN
cusj-10288	16	3	also	also	ADV
cusj-10288	16	4	suffer	suffer	VERB
cusj-10288	16	5	from	from	ADP
cusj-10288	16	6	cognitive	cognitive	ADJ
cusj-10288	16	7	decline	decline	NOUN
cusj-10288	16	8	and	and	CCONJ
cusj-10288	16	9	psychiatric	psychiatric	ADJ
cusj-10288	16	10	symptoms	symptom	NOUN
cusj-10288	16	11	,	,	PUNCT
cusj-10288	16	12	such	such	ADJ
cusj-10288	16	13	as	as	ADP
cusj-10288	16	14	mood	mood	NOUN
cusj-10288	16	15	disorders	disorder	NOUN
cusj-10288	16	16	and	and	CCONJ
cusj-10288	16	17	social	social	ADJ
cusj-10288	16	18	changes	change	NOUN
cusj-10288	16	19	.	.	PUNCT
cusj-10288	17	1	these	these	DET
cusj-10288	17	2	symptoms	symptom	NOUN
cusj-10288	17	3	are	be	AUX
cusj-10288	17	4	chronic	chronic	ADJ
cusj-10288	17	5	and	and	CCONJ
cusj-10288	17	6	progressive	progressive	ADJ
cusj-10288	17	7	,	,	PUNCT
cusj-10288	17	8	leading	lead	VERB
cusj-10288	17	9	to	to	ADP
cusj-10288	17	10	complete	complete	ADJ
cusj-10288	17	11	dependence	dependence	NOUN
cusj-10288	17	12	and	and	CCONJ
cusj-10288	17	13	death	death	NOUN
cusj-10288	17	14	.	.	PUNCT
cusj-10288	18	1	chorea	chorea	PROPN
cusj-10288	18	2	can	can	AUX
cusj-10288	18	3	also	also	ADV
cusj-10288	18	4	be	be	AUX
cusj-10288	18	5	caused	cause	VERB
cusj-10288	18	6	by	by	ADP
cusj-10288	18	7	other	other	ADJ
cusj-10288	18	8	conditions	condition	NOUN
cusj-10288	18	9	,	,	PUNCT
cusj-10288	18	10	such	such	ADJ
cusj-10288	18	11	as	as	ADP
cusj-10288	18	12	metabolic	metabolic	NOUN
cusj-10288	18	13	disorders	disorder	NOUN
cusj-10288	18	14	or	or	CCONJ
cusj-10288	18	15	drug	drug	NOUN
cusj-10288	18	16	-	-	PUNCT
cusj-10288	18	17	induced	induce	VERB
cusj-10288	18	18	side	side	NOUN
cusj-10288	18	19	effects	effect	NOUN
cusj-10288	18	20	.	.	PUNCT
cusj-10288	19	1	neuroimaging	neuroimage	VERB
cusj-10288	19	2	techniques	technique	NOUN
cusj-10288	19	3	,	,	PUNCT
cusj-10288	19	4	such	such	ADJ
cusj-10288	19	5	as	as	ADP
cusj-10288	19	6	mr	mr	PROPN
cusj-10288	19	7	imaging	imaging	PROPN
cusj-10288	19	8	,	,	PUNCT
cusj-10288	19	9	fluorodeoxyglucose	fluorodeoxyglucose	ADJ
cusj-10288	19	10	positron	positron	NOUN
cusj-10288	19	11	emission	emission	NOUN
cusj-10288	19	12	tomography	tomography	NOUN
cusj-10288	19	13	(	(	PUNCT
cusj-10288	19	14	fdg	fdg	X
cusj-10288	19	15	-	-	NOUN
cusj-10288	19	16	pet	pet	NOUN
cusj-10288	19	17	)	)	PUNCT
cusj-10288	19	18	,	,	PUNCT
cusj-10288	19	19	mr	mr	PROPN
cusj-10288	19	20	spectroscopy	spectroscopy	NOUN
cusj-10288	19	21	,	,	PUNCT
cusj-10288	19	22	and	and	CCONJ
cusj-10288	19	23	diffusion	diffusion	NOUN
cusj-10288	19	24	tensor	tensor	NOUN
cusj-10288	19	25	imaging	imaging	NOUN
cusj-10288	19	26	,	,	PUNCT
cusj-10288	19	27	can	can	AUX
cusj-10288	19	28	help	help	VERB
cusj-10288	19	29	to	to	PART
cusj-10288	19	30	diagnose	diagnose	VERB
cusj-10288	19	31	hd	hd	NOUN
cusj-10288	19	32	and	and	CCONJ
cusj-10288	19	33	monitor	monitor	VERB
cusj-10288	19	34	its	its	PRON
cusj-10288	19	35	progression	progression	NOUN
cusj-10288	19	36	.	.	PUNCT
cusj-10288	20	1	the	the	DET
cusj-10288	20	2	pathophysiology	pathophysiology	NOUN
cusj-10288	20	3	of	of	ADP
cusj-10288	20	4	hd	hd	NOUN
cusj-10288	20	5	involves	involve	VERB
cusj-10288	20	6	the	the	DET
cusj-10288	20	7	loss	loss	NOUN
cusj-10288	20	8	of	of	ADP
cusj-10288	20	9	neurons	neuron	NOUN
cusj-10288	20	10	and	and	CCONJ
cusj-10288	20	11	the	the	DET
cusj-10288	20	12	dysfunction	dysfunction	NOUN
cusj-10288	20	13	of	of	ADP
cusj-10288	20	14	neurotransmitter	neurotransmitter	NOUN
cusj-10288	20	15	systems	system	NOUN
cusj-10288	20	16	,	,	PUNCT
cusj-10288	20	17	especially	especially	ADV
cusj-10288	20	18	the	the	DET
cusj-10288	20	19	dopaminergic	dopaminergic	ADJ
cusj-10288	20	20	system	system	NOUN
cusj-10288	20	21	.	.	PUNCT
cusj-10288	21	1	there	there	PRON
cusj-10288	21	2	is	be	VERB
cusj-10288	21	3	no	no	DET
cusj-10288	21	4	cure	cure	NOUN
cusj-10288	21	5	for	for	ADP
cusj-10288	21	6	hd	hd	NOUN
cusj-10288	21	7	,	,	PUNCT
cusj-10288	21	8	but	but	CCONJ
cusj-10288	21	9	there	there	PRON
cusj-10288	21	10	are	be	VERB
cusj-10288	21	11	treatments	treatment	NOUN
cusj-10288	21	12	to	to	PART
cusj-10288	21	13	manage	manage	VERB
cusj-10288	21	14	the	the	DET
cusj-10288	21	15	symptoms	symptom	NOUN
cusj-10288	21	16	and	and	CCONJ
cusj-10288	21	17	to	to	PART
cusj-10288	21	18	improve	improve	VERB
cusj-10288	21	19	the	the	DET
cusj-10288	21	20	quality	quality	NOUN
cusj-10288	21	21	of	of	ADP
cusj-10288	21	22	life	life	NOUN
cusj-10288	21	23	of	of	ADP
cusj-10288	21	24	hd	hd	NOUN
cusj-10288	21	25	patients	patient	NOUN
cusj-10288	21	26	.	.	PUNCT
cusj-10288	22	1	these	these	PRON
cusj-10288	22	2	include	include	VERB
cusj-10288	22	3	pharmacological	pharmacological	ADJ
cusj-10288	22	4	interventions	intervention	NOUN
cusj-10288	22	5	,	,	PUNCT
cusj-10288	22	6	such	such	ADJ
cusj-10288	22	7	as	as	ADP
cusj-10288	22	8	dopamine	dopamine	NOUN
cusj-10288	22	9	receptor	receptor	NOUN
cusj-10288	22	10	antagonists	antagonist	NOUN
cusj-10288	22	11	or	or	CCONJ
cusj-10288	22	12	depleters	depleter	NOUN
cusj-10288	22	13	,	,	PUNCT
cusj-10288	22	14	and	and	CCONJ
cusj-10288	22	15	nonpharmacological	nonpharmacological	ADJ
cusj-10288	22	16	interventions	intervention	NOUN
cusj-10288	22	17	,	,	PUNCT
cusj-10288	22	18	such	such	ADJ
cusj-10288	22	19	as	as	ADP
cusj-10288	22	20	psychological	psychological	ADJ
cusj-10288	22	21	and	and	CCONJ
cusj-10288	22	22	social	social	ADJ
cusj-10288	22	23	support	support	NOUN
cusj-10288	22	24	.	.	PUNCT
cusj-10288	23	1	hd	hd	PROPN
cusj-10288	23	2	is	be	AUX
cusj-10288	23	3	a	a	DET
cusj-10288	23	4	devastating	devastating	ADJ
cusj-10288	23	5	disease	disease	NOUN
cusj-10288	23	6	that	that	PRON
cusj-10288	23	7	poses	pose	VERB
cusj-10288	23	8	many	many	ADJ
cusj-10288	23	9	challenges	challenge	NOUN
cusj-10288	23	10	for	for	ADP
cusj-10288	23	11	patients	patient	NOUN
cusj-10288	23	12	,	,	PUNCT
cusj-10288	23	13	families	family	NOUN
cusj-10288	23	14	,	,	PUNCT
cusj-10288	23	15	and	and	CCONJ
cusj-10288	23	16	healthcare	healthcare	NOUN
cusj-10288	23	17	providers	provider	NOUN
cusj-10288	23	18	.	.	PUNCT
cusj-10288	24	1	there	there	PRON
cusj-10288	24	2	is	be	VERB
cusj-10288	24	3	hope	hope	NOUN
cusj-10288	24	4	that	that	SCONJ
cusj-10288	24	5	genetargeted	genetargete	VERB
cusj-10288	24	6	therapies	therapy	NOUN
cusj-10288	24	7	will	will	AUX
cusj-10288	24	8	be	be	AUX
cusj-10288	24	9	developed	develop	VERB
cusj-10288	24	10	in	in	ADP
cusj-10288	24	11	the	the	DET
cusj-10288	24	12	near	near	ADJ
cusj-10288	24	13	future	future	NOUN
cusj-10288	24	14	to	to	PART
cusj-10288	24	15	stop	stop	VERB
cusj-10288	24	16	or	or	CCONJ
cusj-10288	24	17	slow	slow	VERB
cusj-10288	24	18	down	down	ADP
cusj-10288	24	19	the	the	DET
cusj-10288	24	20	disease	disease	NOUN
cusj-10288	24	21	process	process	NOUN
cusj-10288	24	22	.	.	PUNCT
cusj-10288	25	1	introduction	introduction	NOUN
cusj-10288	25	2	huntington	huntington	PROPN
cusj-10288	25	3	disease	disease	PROPN
cusj-10288	25	4	(	(	PUNCT
cusj-10288	25	5	hd	hd	NOUN
cusj-10288	25	6	)	)	PUNCT
cusj-10288	25	7	is	be	AUX
cusj-10288	25	8	a	a	DET
cusj-10288	25	9	fatal	fatal	ADJ
cusj-10288	25	10	neurodegenerative	neurodegenerative	ADJ
cusj-10288	25	11	disorder	disorder	NOUN
cusj-10288	25	12	that	that	PRON
cusj-10288	25	13	affects	affect	VERB
cusj-10288	25	14	the	the	DET
cusj-10288	25	15	cns	cns	NOUN
cusj-10288	25	16	and	and	CCONJ
cusj-10288	25	17	causes	cause	VERB
cusj-10288	25	18	motor	motor	NOUN
cusj-10288	25	19	,	,	PUNCT
cusj-10288	25	20	cognitive	cognitive	NOUN
cusj-10288	25	21	,	,	PUNCT
cusj-10288	25	22	and	and	CCONJ
cusj-10288	25	23	behavioural	behavioural	ADJ
cusj-10288	25	24	problems	problem	NOUN
cusj-10288	25	25	in	in	ADP
cusj-10288	25	26	the	the	DET
cusj-10288	25	27	patients	patient	NOUN
cusj-10288	25	28	[	[	X
cusj-10288	25	29	1	1	NUM
cusj-10288	25	30	]	]	PUNCT
cusj-10288	25	31	.	.	PUNCT
cusj-10288	26	1	the	the	DET
cusj-10288	26	2	disease	disease	NOUN
cusj-10288	26	3	is	be	AUX
cusj-10288	26	4	inherited	inherit	VERB
cusj-10288	26	5	in	in	ADP
cusj-10288	26	6	an	an	DET
cusj-10288	26	7	autosomal	autosomal	ADJ
cusj-10288	26	8	dominant	dominant	ADJ
cusj-10288	26	9	manner	manner	NOUN
cusj-10288	26	10	and	and	CCONJ
cusj-10288	26	11	is	be	AUX
cusj-10288	26	12	caused	cause	VERB
cusj-10288	26	13	by	by	ADP
cusj-10288	26	14	a	a	DET
cusj-10288	26	15	mutation	mutation	NOUN
cusj-10288	26	16	in	in	ADP
cusj-10288	26	17	the	the	DET
cusj-10288	26	18	htt	htt	NOUN
cusj-10288	26	19	gene	gene	NOUN
cusj-10288	26	20	that	that	PRON
cusj-10288	26	21	results	result	VERB
cusj-10288	26	22	in	in	ADP
cusj-10288	26	23	an	an	DET
cusj-10288	26	24	expansion	expansion	NOUN
cusj-10288	26	25	of	of	ADP
cusj-10288	26	26	the	the	DET
cusj-10288	26	27	polyq	polyq	NOUN
cusj-10288	26	28	domain	domain	NOUN
cusj-10288	26	29	of	of	ADP
cusj-10288	26	30	the	the	DET
cusj-10288	26	31	htt	htt	NOUN
cusj-10288	26	32	protein	protein	NOUN
cusj-10288	26	33	beyond	beyond	ADP
cusj-10288	26	34	36	36	NUM
cusj-10288	26	35	glutamines	glutamine	NOUN
cusj-10288	27	1	[	[	X
cusj-10288	27	2	3	3	NUM
cusj-10288	27	3	]	]	PUNCT
cusj-10288	27	4	.	.	PUNCT
cusj-10288	28	1	the	the	DET
cusj-10288	28	2	brain	brain	NOUN
cusj-10288	28	3	cells	cell	NOUN
cusj-10288	28	4	of	of	ADP
cusj-10288	28	5	hd	hd	NOUN
cusj-10288	28	6	patients	patient	NOUN
cusj-10288	28	7	have	have	AUX
cusj-10288	28	8	misfolded	misfolde	VERB
cusj-10288	28	9	polyq	polyq	NOUN
cusj-10288	28	10	htt	htt	NOUN
cusj-10288	28	11	proteins	protein	NOUN
cusj-10288	28	12	that	that	PRON
cusj-10288	28	13	form	form	VERB
cusj-10288	28	14	columbia	columbia	PROPN
cusj-10288	28	15	undergraduate	undergraduate	PROPN
cusj-10288	28	16	science	science	PROPN
cusj-10288	28	17	journal	journal	PROPN
cusj-10288	28	18	vol	vol	NOUN
cusj-10288	28	19	.	.	PROPN
cusj-10288	28	20	17	17	NUM
cusj-10288	28	21	,	,	PUNCT
cusj-10288	28	22	2023	2023	NUM
cusj-10288	28	23	datta	datta	NOUN
cusj-10288	28	24	18	18	NUM
cusj-10288	28	25	clumps	clump	NOUN
cusj-10288	28	26	,	,	PUNCT
cusj-10288	28	27	unlike	unlike	ADP
cusj-10288	28	28	the	the	DET
cusj-10288	28	29	normal	normal	ADJ
cusj-10288	28	30	individuals	individual	NOUN
cusj-10288	28	31	who	who	PRON
cusj-10288	28	32	have	have	VERB
cusj-10288	28	33	diffuse	diffuse	NOUN
cusj-10288	28	34	localization	localization	NOUN
cusj-10288	28	35	of	of	ADP
cusj-10288	28	36	htt	htt	NOUN
cusj-10288	28	37	[	[	X
cusj-10288	28	38	12	12	NUM
cusj-10288	28	39	]	]	PUNCT
cusj-10288	28	40	.	.	PUNCT
cusj-10288	29	1	the	the	DET
cusj-10288	29	2	length	length	NOUN
cusj-10288	29	3	of	of	ADP
cusj-10288	29	4	the	the	DET
cusj-10288	29	5	polyq	polyq	NOUN
cusj-10288	29	6	expansion	expansion	NOUN
cusj-10288	29	7	determines	determine	VERB
cusj-10288	29	8	how	how	SCONJ
cusj-10288	29	9	fast	fast	ADV
cusj-10288	29	10	the	the	DET
cusj-10288	29	11	aggregation	aggregation	NOUN
cusj-10288	29	12	occurs	occur	VERB
cusj-10288	29	13	[	[	X
cusj-10288	29	14	13	13	NUM
cusj-10288	29	15	]	]	PUNCT
cusj-10288	29	16	.	.	PUNCT
cusj-10288	30	1	the	the	DET
cusj-10288	30	2	normal	normal	ADJ
cusj-10288	30	3	function	function	NOUN
cusj-10288	30	4	of	of	ADP
cusj-10288	30	5	the	the	DET
cusj-10288	30	6	cell	cell	NOUN
cusj-10288	30	7	to	to	PART
cusj-10288	30	8	recycle	recycle	VERB
cusj-10288	30	9	and	and	CCONJ
cusj-10288	30	10	degrade	degrade	VERB
cusj-10288	30	11	proteins	protein	NOUN
cusj-10288	30	12	and	and	CCONJ
cusj-10288	30	13	produce	produce	VERB
cusj-10288	30	14	energy	energy	NOUN
cusj-10288	30	15	is	be	AUX
cusj-10288	30	16	disrupted	disrupt	VERB
cusj-10288	30	17	by	by	ADP
cusj-10288	30	18	the	the	DET
cusj-10288	30	19	misfolded	misfolded	ADJ
cusj-10288	30	20	polyq	polyq	NOUN
cusj-10288	30	21	htt	htt	NOUN
cusj-10288	30	22	,	,	PUNCT
cusj-10288	30	23	which	which	PRON
cusj-10288	30	24	also	also	ADV
cusj-10288	30	25	binds	bind	VERB
cusj-10288	30	26	to	to	ADP
cusj-10288	30	27	other	other	ADJ
cusj-10288	30	28	proteins	protein	NOUN
cusj-10288	30	29	such	such	ADJ
cusj-10288	30	30	as	as	ADP
cusj-10288	30	31	creb	creb	NOUN
cusj-10288	30	32	binding	bind	VERB
cusj-10288	30	33	protein	protein	NOUN
cusj-10288	30	34	and	and	CCONJ
cusj-10288	30	35	depletes	deplete	VERB
cusj-10288	30	36	them	they	PRON
cusj-10288	30	37	from	from	ADP
cusj-10288	30	38	the	the	DET
cusj-10288	30	39	cell	cell	NOUN
cusj-10288	30	40	[	[	X
cusj-10288	30	41	14	14	NUM
cusj-10288	30	42	]	]	PUNCT
cusj-10288	30	43	.	.	PUNCT
cusj-10288	31	1	this	this	PRON
cusj-10288	31	2	leads	lead	VERB
cusj-10288	31	3	to	to	ADP
cusj-10288	31	4	a	a	DET
cusj-10288	31	5	toxic	toxic	ADJ
cusj-10288	31	6	effect	effect	NOUN
cusj-10288	31	7	of	of	ADP
cusj-10288	31	8	the	the	DET
cusj-10288	31	9	mutant	mutant	ADJ
cusj-10288	31	10	htt	htt	NOUN
cusj-10288	31	11	,	,	PUNCT
cusj-10288	31	12	but	but	CCONJ
cusj-10288	31	13	it	it	PRON
cusj-10288	31	14	also	also	ADV
cusj-10288	31	15	affects	affect	VERB
cusj-10288	31	16	the	the	DET
cusj-10288	31	17	normal	normal	ADJ
cusj-10288	31	18	function	function	NOUN
cusj-10288	31	19	of	of	ADP
cusj-10288	31	20	the	the	DET
cusj-10288	31	21	wildtype	wildtype	NOUN
cusj-10288	31	22	htt	htt	NOUN
cusj-10288	31	23	,	,	PUNCT
cusj-10288	31	24	which	which	PRON
cusj-10288	31	25	does	do	AUX
cusj-10288	31	26	not	not	PART
cusj-10288	31	27	have	have	VERB
cusj-10288	31	28	the	the	DET
cusj-10288	31	29	polyq	polyq	NOUN
cusj-10288	31	30	expansion	expansion	NOUN
cusj-10288	32	1	[	[	X
cusj-10288	32	2	2	2	NUM
cusj-10288	32	3	,	,	PUNCT
cusj-10288	32	4	15	15	NUM
cusj-10288	32	5	]	]	PUNCT
cusj-10288	32	6	.	.	PUNCT
cusj-10288	33	1	therefore	therefore	ADV
cusj-10288	33	2	,	,	PUNCT
cusj-10288	33	3	any	any	DET
cusj-10288	33	4	treatment	treatment	NOUN
cusj-10288	33	5	for	for	ADP
cusj-10288	33	6	hd	hd	NOUN
cusj-10288	33	7	must	must	AUX
cusj-10288	33	8	consider	consider	VERB
cusj-10288	33	9	both	both	CCONJ
cusj-10288	33	10	the	the	DET
cusj-10288	33	11	gain	gain	VERB
cusj-10288	33	12	-	-	PUNCT
cusj-10288	33	13	of	of	ADP
cusj-10288	33	14	-	-	PUNCT
cusj-10288	33	15	function	function	NOUN
cusj-10288	33	16	and	and	CCONJ
cusj-10288	33	17	the	the	DET
cusj-10288	33	18	loss	loss	NOUN
cusj-10288	33	19	-	-	PUNCT
cusj-10288	33	20	of	of	ADP
cusj-10288	33	21	-	-	PUNCT
cusj-10288	33	22	function	function	NOUN
cusj-10288	33	23	effects	effect	NOUN
cusj-10288	33	24	of	of	ADP
cusj-10288	33	25	the	the	DET
cusj-10288	33	26	mutant	mutant	ADJ
cusj-10288	33	27	htt	htt	NOUN
cusj-10288	33	28	.	.	PUNCT
cusj-10288	34	1	the	the	DET
cusj-10288	34	2	age	age	NOUN
cusj-10288	34	3	of	of	ADP
cusj-10288	34	4	onset	onset	NOUN
cusj-10288	34	5	of	of	ADP
cusj-10288	34	6	hd	hd	NOUN
cusj-10288	34	7	depends	depend	VERB
cusj-10288	34	8	on	on	ADP
cusj-10288	34	9	the	the	DET
cusj-10288	34	10	length	length	NOUN
cusj-10288	34	11	of	of	ADP
cusj-10288	34	12	the	the	DET
cusj-10288	34	13	polyq	polyq	NOUN
cusj-10288	34	14	expansion	expansion	NOUN
cusj-10288	34	15	,	,	PUNCT
cusj-10288	34	16	with	with	ADP
cusj-10288	34	17	longer	long	ADJ
cusj-10288	34	18	expansions	expansion	NOUN
cusj-10288	34	19	causing	cause	VERB
cusj-10288	34	20	earlier	early	ADV
cusj-10288	34	21	and	and	CCONJ
cusj-10288	34	22	more	more	ADV
cusj-10288	34	23	severe	severe	ADJ
cusj-10288	34	24	symptoms	symptom	NOUN
cusj-10288	34	25	[	[	X
cusj-10288	34	26	4	4	NUM
cusj-10288	34	27	]	]	PUNCT
cusj-10288	34	28	.	.	PUNCT
cusj-10288	35	1	the	the	DET
cusj-10288	35	2	polyq	polyq	NOUN
cusj-10288	35	3	length	length	NOUN
cusj-10288	35	4	explains	explain	VERB
cusj-10288	35	5	60	60	NUM
cusj-10288	35	6	-	-	SYM
cusj-10288	35	7	70	70	NUM
cusj-10288	35	8	%	%	NOUN
cusj-10288	35	9	of	of	ADP
cusj-10288	35	10	the	the	DET
cusj-10288	35	11	variation	variation	NOUN
cusj-10288	35	12	in	in	ADP
cusj-10288	35	13	the	the	DET
cusj-10288	35	14	age	age	NOUN
cusj-10288	35	15	of	of	ADP
cusj-10288	35	16	onset	onset	NOUN
cusj-10288	35	17	,	,	PUNCT
cusj-10288	35	18	while	while	SCONJ
cusj-10288	35	19	the	the	DET
cusj-10288	35	20	rest	rest	NOUN
cusj-10288	35	21	is	be	AUX
cusj-10288	35	22	influenced	influence	VERB
cusj-10288	35	23	by	by	ADP
cusj-10288	35	24	environmental	environmental	ADJ
cusj-10288	35	25	and	and	CCONJ
cusj-10288	35	26	genetic	genetic	ADJ
cusj-10288	35	27	factors	factor	NOUN
cusj-10288	35	28	[	[	X
cusj-10288	35	29	5	5	NUM
cusj-10288	35	30	]	]	PUNCT
cusj-10288	35	31	.	.	PUNCT
cusj-10288	36	1	the	the	DET
cusj-10288	36	2	main	main	ADJ
cusj-10288	36	3	feature	feature	NOUN
cusj-10288	36	4	of	of	ADP
cusj-10288	36	5	hd	hd	NOUN
cusj-10288	36	6	pathology	pathology	NOUN
cusj-10288	36	7	is	be	AUX
cusj-10288	36	8	the	the	DET
cusj-10288	36	9	death	death	NOUN
cusj-10288	36	10	of	of	ADP
cusj-10288	36	11	the	the	DET
cusj-10288	36	12	gabaergic	gabaergic	ADJ
cusj-10288	36	13	msn	msn	NOUN
cusj-10288	36	14	in	in	ADP
cusj-10288	36	15	the	the	DET
cusj-10288	36	16	striatum	striatum	NOUN
cusj-10288	36	17	,	,	PUNCT
cusj-10288	36	18	which	which	PRON
cusj-10288	36	19	is	be	AUX
cusj-10288	36	20	a	a	DET
cusj-10288	36	21	part	part	NOUN
cusj-10288	36	22	of	of	ADP
cusj-10288	36	23	the	the	DET
cusj-10288	36	24	brain	brain	NOUN
cusj-10288	36	25	that	that	PRON
cusj-10288	36	26	controls	control	VERB
cusj-10288	36	27	movement	movement	NOUN
cusj-10288	36	28	and	and	CCONJ
cusj-10288	36	29	cognition	cognition	NOUN
cusj-10288	36	30	[	[	X
cusj-10288	36	31	2	2	NUM
cusj-10288	36	32	,	,	PUNCT
cusj-10288	36	33	6	6	NUM
cusj-10288	36	34	]	]	PUNCT
cusj-10288	36	35	.	.	PUNCT
cusj-10288	37	1	the	the	DET
cusj-10288	37	2	death	death	NOUN
cusj-10288	37	3	of	of	ADP
cusj-10288	37	4	the	the	DET
cusj-10288	37	5	msn	msn	NOUN
cusj-10288	37	6	is	be	AUX
cusj-10288	37	7	accompanied	accompany	VERB
cusj-10288	37	8	by	by	ADP
cusj-10288	37	9	inflammation	inflammation	NOUN
cusj-10288	37	10	and	and	CCONJ
cusj-10288	37	11	activation	activation	NOUN
cusj-10288	37	12	of	of	ADP
cusj-10288	37	13	glial	glial	ADJ
cusj-10288	37	14	cells	cell	NOUN
cusj-10288	37	15	,	,	PUNCT
cusj-10288	37	16	which	which	PRON
cusj-10288	37	17	are	be	AUX
cusj-10288	37	18	the	the	DET
cusj-10288	37	19	support	support	NOUN
cusj-10288	37	20	cells	cell	NOUN
cusj-10288	37	21	of	of	ADP
cusj-10288	37	22	the	the	DET
cusj-10288	37	23	cns	cns	NOUN
cusj-10288	38	1	[	[	X
cusj-10288	38	2	2	2	NUM
cusj-10288	38	3	]	]	PUNCT
cusj-10288	38	4	.	.	PUNCT
cusj-10288	39	1	microglia	microglia	PROPN
cusj-10288	39	2	,	,	PUNCT
cusj-10288	39	3	which	which	PRON
cusj-10288	39	4	are	be	AUX
cusj-10288	39	5	the	the	DET
cusj-10288	39	6	immune	immune	ADJ
cusj-10288	39	7	cells	cell	NOUN
cusj-10288	39	8	of	of	ADP
cusj-10288	39	9	the	the	DET
cusj-10288	39	10	cns	cns	NOUN
cusj-10288	39	11	,	,	PUNCT
cusj-10288	39	12	are	be	AUX
cusj-10288	39	13	activated	activate	VERB
cusj-10288	39	14	in	in	ADP
cusj-10288	39	15	both	both	CCONJ
cusj-10288	39	16	early	early	ADJ
cusj-10288	39	17	and	and	CCONJ
cusj-10288	39	18	late	late	ADJ
cusj-10288	39	19	stages	stage	NOUN
cusj-10288	39	20	of	of	ADP
cusj-10288	39	21	hd	hd	NOUN
cusj-10288	39	22	and	and	CCONJ
cusj-10288	39	23	cause	cause	VERB
cusj-10288	39	24	damage	damage	NOUN
cusj-10288	39	25	to	to	ADP
cusj-10288	39	26	the	the	DET
cusj-10288	39	27	neurons	neuron	NOUN
cusj-10288	39	28	in	in	ADP
cusj-10288	39	29	the	the	DET
cusj-10288	39	30	striatum	striatum	NOUN
cusj-10288	39	31	and	and	CCONJ
cusj-10288	39	32	cortex	cortex	NOUN
cusj-10288	39	33	[	[	X
cusj-10288	39	34	7	7	NUM
cusj-10288	39	35	]	]	PUNCT
cusj-10288	39	36	.	.	PUNCT
cusj-10288	40	1	astrocytes	astrocyte	NOUN
cusj-10288	40	2	and	and	CCONJ
cusj-10288	40	3	oligodendroglia	oligodendroglia	NOUN
cusj-10288	40	4	,	,	PUNCT
cusj-10288	40	5	which	which	PRON
cusj-10288	40	6	are	be	AUX
cusj-10288	40	7	the	the	DET
cusj-10288	40	8	cells	cell	NOUN
cusj-10288	40	9	that	that	PRON
cusj-10288	40	10	provide	provide	VERB
cusj-10288	40	11	nutrients	nutrient	NOUN
cusj-10288	40	12	and	and	CCONJ
cusj-10288	40	13	insulation	insulation	NOUN
cusj-10288	40	14	to	to	ADP
cusj-10288	40	15	the	the	DET
cusj-10288	40	16	neurons	neuron	NOUN
cusj-10288	40	17	,	,	PUNCT
cusj-10288	40	18	are	be	AUX
cusj-10288	40	19	also	also	ADV
cusj-10288	40	20	increased	increase	VERB
cusj-10288	40	21	in	in	ADP
cusj-10288	40	22	hd	hd	NOUN
cusj-10288	40	23	brains	brain	NOUN
cusj-10288	40	24	,	,	PUNCT
cusj-10288	40	25	especially	especially	ADV
cusj-10288	40	26	in	in	ADP
cusj-10288	40	27	the	the	DET
cusj-10288	40	28	globus	globus	NOUN
cusj-10288	40	29	pallidus	pallidus	NOUN
cusj-10288	40	30	and	and	CCONJ
cusj-10288	40	31	the	the	DET
cusj-10288	40	32	white	white	ADJ
cusj-10288	40	33	matter	matter	NOUN
cusj-10288	40	34	surrounding	surround	VERB
cusj-10288	40	35	it	it	PRON
cusj-10288	40	36	[	[	X
cusj-10288	40	37	8	8	NUM
cusj-10288	40	38	]	]	PUNCT
cusj-10288	40	39	.	.	PUNCT
cusj-10288	41	1	hd	hd	NOUN
cusj-10288	41	2	patients	patient	NOUN
cusj-10288	41	3	also	also	ADV
cusj-10288	41	4	show	show	VERB
cusj-10288	41	5	a	a	DET
cusj-10288	41	6	significant	significant	ADJ
cusj-10288	41	7	loss	loss	NOUN
cusj-10288	41	8	of	of	ADP
cusj-10288	41	9	brain	brain	NOUN
cusj-10288	41	10	volume	volume	NOUN
cusj-10288	41	11	in	in	ADP
cusj-10288	41	12	different	different	ADJ
cusj-10288	41	13	regions	region	NOUN
cusj-10288	41	14	,	,	PUNCT
cusj-10288	41	15	such	such	ADJ
cusj-10288	41	16	as	as	ADP
cusj-10288	41	17	the	the	DET
cusj-10288	41	18	cerebral	cerebral	ADJ
cusj-10288	41	19	cortex	cortex	NOUN
cusj-10288	41	20	,	,	PUNCT
cusj-10288	41	21	the	the	DET
cusj-10288	41	22	telencephalic	telencephalic	ADJ
cusj-10288	41	23	white	white	ADJ
cusj-10288	41	24	matter	matter	NOUN
cusj-10288	41	25	,	,	PUNCT
cusj-10288	41	26	the	the	DET
cusj-10288	41	27	putamen	putaman	NOUN
cusj-10288	41	28	,	,	PUNCT
cusj-10288	41	29	and	and	CCONJ
cusj-10288	41	30	the	the	DET
cusj-10288	41	31	caudate	caudate	ADJ
cusj-10288	41	32	nucleus	nucleus	NOUN
cusj-10288	41	33	[	[	X
cusj-10288	41	34	2	2	NUM
cusj-10288	41	35	,	,	PUNCT
cusj-10288	41	36	9	9	NUM
cusj-10288	41	37	,	,	PUNCT
cusj-10288	41	38	11	11	NUM
cusj-10288	41	39	]	]	PUNCT
cusj-10288	41	40	.	.	PUNCT
cusj-10288	42	1	the	the	DET
cusj-10288	42	2	loss	loss	NOUN
cusj-10288	42	3	of	of	ADP
cusj-10288	42	4	brain	brain	NOUN
cusj-10288	42	5	volume	volume	NOUN
cusj-10288	42	6	can	can	AUX
cusj-10288	42	7	be	be	AUX
cusj-10288	42	8	detected	detect	VERB
cusj-10288	42	9	even	even	ADV
cusj-10288	42	10	before	before	SCONJ
cusj-10288	42	11	the	the	DET
cusj-10288	42	12	symptoms	symptom	NOUN
cusj-10288	42	13	of	of	ADP
cusj-10288	42	14	hd	hd	NOUN
cusj-10288	42	15	appear	appear	VERB
cusj-10288	42	16	,	,	PUNCT
cusj-10288	42	17	indicating	indicate	VERB
cusj-10288	42	18	an	an	DET
cusj-10288	42	19	early	early	ADJ
cusj-10288	42	20	degeneration	degeneration	NOUN
cusj-10288	42	21	of	of	ADP
cusj-10288	42	22	the	the	DET
cusj-10288	42	23	brain	brain	NOUN
cusj-10288	43	1	[	[	X
cusj-10288	43	2	10	10	NUM
cusj-10288	43	3	]	]	PUNCT
cusj-10288	43	4	.	.	PUNCT
cusj-10288	44	1	hd	hd	PROPN
cusj-10288	44	2	is	be	AUX
cusj-10288	44	3	a	a	DET
cusj-10288	44	4	disease	disease	NOUN
cusj-10288	44	5	that	that	PRON
cusj-10288	44	6	affects	affect	VERB
cusj-10288	44	7	the	the	DET
cusj-10288	44	8	whole	whole	ADJ
cusj-10288	44	9	brain	brain	NOUN
cusj-10288	44	10	and	and	CCONJ
cusj-10288	44	11	causes	cause	VERB
cusj-10288	44	12	progressive	progressive	ADJ
cusj-10288	44	13	deterioration	deterioration	NOUN
cusj-10288	44	14	of	of	ADP
cusj-10288	44	15	the	the	DET
cusj-10288	44	16	patients	patient	NOUN
cusj-10288	44	17	'	'	PART
cusj-10288	44	18	functions	function	NOUN
cusj-10288	44	19	and	and	CCONJ
cusj-10288	44	20	quality	quality	NOUN
cusj-10288	44	21	of	of	ADP
cusj-10288	44	22	life	life	NOUN
cusj-10288	44	23	.	.	PUNCT
cusj-10288	45	1	there	there	PRON
cusj-10288	45	2	is	be	VERB
cusj-10288	45	3	no	no	DET
cusj-10288	45	4	cure	cure	NOUN
cusj-10288	45	5	for	for	ADP
cusj-10288	45	6	hd	hd	NOUN
cusj-10288	45	7	,	,	PUNCT
cusj-10288	45	8	and	and	CCONJ
cusj-10288	45	9	the	the	DET
cusj-10288	45	10	current	current	ADJ
cusj-10288	45	11	treatments	treatment	NOUN
cusj-10288	45	12	are	be	AUX
cusj-10288	45	13	only	only	ADV
cusj-10288	45	14	palliative	palliative	ADJ
cusj-10288	45	15	and	and	CCONJ
cusj-10288	45	16	symptomatic	symptomatic	ADJ
cusj-10288	45	17	.	.	PUNCT
cusj-10288	46	1	structure	structure	NOUN
cusj-10288	46	2	of	of	ADP
cusj-10288	46	3	the	the	DET
cusj-10288	46	4	huntingtin	huntingtin	ADJ
cusj-10288	46	5	protein	protein	NOUN
cusj-10288	46	6	the	the	DET
cusj-10288	46	7	huntingtin	huntingtin	NOUN
cusj-10288	46	8	(	(	PUNCT
cusj-10288	46	9	htt	htt	NOUN
cusj-10288	46	10	)	)	PUNCT
cusj-10288	46	11	protein	protein	NOUN
cusj-10288	46	12	is	be	AUX
cusj-10288	46	13	a	a	DET
cusj-10288	46	14	molecule	molecule	NOUN
cusj-10288	46	15	that	that	PRON
cusj-10288	46	16	is	be	AUX
cusj-10288	46	17	found	find	VERB
cusj-10288	46	18	in	in	ADP
cusj-10288	46	19	humans	human	NOUN
cusj-10288	46	20	and	and	CCONJ
cusj-10288	46	21	other	other	ADJ
cusj-10288	46	22	vertebrates	vertebrate	NOUN
cusj-10288	46	23	,	,	PUNCT
cusj-10288	46	24	and	and	CCONJ
cusj-10288	46	25	it	it	PRON
cusj-10288	46	26	has	have	VERB
cusj-10288	46	27	a	a	DET
cusj-10288	46	28	very	very	ADV
cusj-10288	46	29	similar	similar	ADJ
cusj-10288	46	30	structure	structure	NOUN
cusj-10288	46	31	and	and	CCONJ
cusj-10288	46	32	function	function	NOUN
cusj-10288	46	33	among	among	ADP
cusj-10288	46	34	them	they	PRON
cusj-10288	46	35	[	[	X
cusj-10288	46	36	2,16	2,16	NUM
cusj-10288	46	37	]	]	X
cusj-10288	46	38	.	.	PUNCT
cusj-10288	47	1	it	it	PRON
cusj-10288	47	2	is	be	AUX
cusj-10288	47	3	a	a	DET
cusj-10288	47	4	big	big	ADJ
cusj-10288	47	5	protein	protein	NOUN
cusj-10288	47	6	,	,	PUNCT
cusj-10288	47	7	with	with	ADP
cusj-10288	47	8	a	a	DET
cusj-10288	47	9	molecular	molecular	ADJ
cusj-10288	47	10	weight	weight	NOUN
cusj-10288	47	11	of	of	ADP
cusj-10288	47	12	about	about	ADV
cusj-10288	47	13	350	350	NUM
cusj-10288	47	14	kda	kda	NOUN
cusj-10288	47	15	,	,	PUNCT
cusj-10288	47	16	and	and	CCONJ
cusj-10288	47	17	it	it	PRON
cusj-10288	47	18	has	have	VERB
cusj-10288	47	19	a	a	DET
cusj-10288	47	20	shape	shape	NOUN
cusj-10288	47	21	that	that	PRON
cusj-10288	47	22	is	be	AUX
cusj-10288	47	23	long	long	ADJ
cusj-10288	47	24	and	and	CCONJ
cusj-10288	47	25	flexible	flexible	ADJ
cusj-10288	47	26	[	[	X
cusj-10288	47	27	17,18	17,18	NUM
cusj-10288	47	28	]	]	X
cusj-10288	47	29	.	.	PUNCT
cusj-10288	48	1	the	the	DET
cusj-10288	48	2	protein	protein	NOUN
cusj-10288	48	3	is	be	AUX
cusj-10288	48	4	made	make	VERB
cusj-10288	48	5	up	up	ADP
cusj-10288	48	6	of	of	ADP
cusj-10288	48	7	many	many	ADJ
cusj-10288	48	8	repeated	repeat	VERB
cusj-10288	48	9	units	unit	NOUN
cusj-10288	48	10	called	call	VERB
cusj-10288	48	11	heat	heat	NOUN
cusj-10288	48	12	(	(	PUNCT
cusj-10288	48	13	huntingtin	huntingtin	PROPN
cusj-10288	48	14	,	,	PUNCT
cusj-10288	48	15	elongator	elongator	NOUN
cusj-10288	48	16	factor3	factor3	PROPN
cusj-10288	48	17	,	,	PUNCT
cusj-10288	48	18	pr65	pr65	PROPN
cusj-10288	48	19	/	/	SYM
cusj-10288	48	20	a	a	DET
cusj-10288	48	21	regulatory	regulatory	ADJ
cusj-10288	48	22	subunits	subunit	NOUN
cusj-10288	48	23	of	of	ADP
cusj-10288	48	24	pp2a	pp2a	PROPN
cusj-10288	48	25	,	,	PUNCT
cusj-10288	48	26	and	and	CCONJ
cusj-10288	48	27	tor1	tor1	PROPN
cusj-10288	48	28	)	)	PUNCT
cusj-10288	48	29	,	,	PUNCT
cusj-10288	48	30	which	which	PRON
cusj-10288	48	31	help	help	VERB
cusj-10288	48	32	the	the	DET
cusj-10288	48	33	protein	protein	NOUN
cusj-10288	48	34	to	to	PART
cusj-10288	48	35	interact	interact	VERB
cusj-10288	48	36	with	with	ADP
cusj-10288	48	37	other	other	ADJ
cusj-10288	48	38	proteins	protein	NOUN
cusj-10288	48	39	and	and	CCONJ
cusj-10288	48	40	to	to	PART
cusj-10288	48	41	form	form	VERB
cusj-10288	48	42	complex	complex	ADJ
cusj-10288	48	43	structures	structure	NOUN
cusj-10288	48	44	[	[	X
cusj-10288	48	45	2,24	2,24	X
cusj-10288	48	46	]	]	X
cusj-10288	48	47	.	.	PUNCT
cusj-10288	49	1	one	one	NUM
cusj-10288	49	2	of	of	ADP
cusj-10288	49	3	the	the	DET
cusj-10288	49	4	special	special	ADJ
cusj-10288	49	5	features	feature	NOUN
cusj-10288	49	6	of	of	ADP
cusj-10288	49	7	the	the	DET
cusj-10288	49	8	htt	htt	NOUN
cusj-10288	49	9	protein	protein	NOUN
cusj-10288	49	10	is	be	AUX
cusj-10288	49	11	that	that	SCONJ
cusj-10288	49	12	it	it	PRON
cusj-10288	49	13	has	have	VERB
cusj-10288	49	14	a	a	DET
cusj-10288	49	15	region	region	NOUN
cusj-10288	49	16	near	near	ADP
cusj-10288	49	17	the	the	DET
cusj-10288	49	18	beginning	beginning	NOUN
cusj-10288	49	19	of	of	ADP
cusj-10288	49	20	the	the	DET
cusj-10288	49	21	protein	protein	NOUN
cusj-10288	49	22	that	that	PRON
cusj-10288	49	23	contains	contain	VERB
cusj-10288	49	24	many	many	ADJ
cusj-10288	49	25	glutamine	glutamine	NOUN
cusj-10288	49	26	residues	residue	NOUN
cusj-10288	49	27	,	,	PUNCT
cusj-10288	49	28	which	which	PRON
cusj-10288	49	29	are	be	AUX
cusj-10288	49	30	amino	amino	ADJ
cusj-10288	49	31	acids	acid	NOUN
cusj-10288	49	32	that	that	PRON
cusj-10288	49	33	have	have	VERB
cusj-10288	49	34	a	a	DET
cusj-10288	49	35	nitrogen	nitrogen	NOUN
cusj-10288	49	36	atom	atom	NOUN
cusj-10288	49	37	in	in	ADP
cusj-10288	49	38	their	their	PRON
cusj-10288	49	39	side	side	NOUN
cusj-10288	49	40	chain	chain	NOUN
cusj-10288	49	41	[	[	X
cusj-10288	49	42	2	2	NUM
cusj-10288	49	43	]	]	PUNCT
cusj-10288	49	44	.	.	PUNCT
cusj-10288	50	1	this	this	DET
cusj-10288	50	2	region	region	NOUN
cusj-10288	50	3	is	be	AUX
cusj-10288	50	4	called	call	VERB
cusj-10288	50	5	the	the	DET
cusj-10288	50	6	polyq	polyq	NOUN
cusj-10288	50	7	tract	tract	NOUN
cusj-10288	50	8	,	,	PUNCT
cusj-10288	50	9	and	and	CCONJ
cusj-10288	50	10	it	it	PRON
cusj-10288	50	11	starts	start	VERB
cusj-10288	50	12	from	from	ADP
cusj-10288	50	13	the	the	DET
cusj-10288	50	14	18th	18th	ADJ
cusj-10288	50	15	amino	amino	NOUN
cusj-10288	50	16	acid	acid	NOUN
cusj-10288	50	17	in	in	ADP
cusj-10288	50	18	the	the	DET
cusj-10288	50	19	protein	protein	NOUN
cusj-10288	50	20	[	[	X
cusj-10288	50	21	2	2	NUM
cusj-10288	50	22	]	]	PUNCT
cusj-10288	50	23	.	.	PUNCT
cusj-10288	51	1	the	the	DET
cusj-10288	51	2	number	number	NOUN
cusj-10288	51	3	of	of	ADP
cusj-10288	51	4	glutamines	glutamine	NOUN
cusj-10288	51	5	in	in	ADP
cusj-10288	51	6	the	the	DET
cusj-10288	51	7	polyq	polyq	NOUN
cusj-10288	51	8	tract	tract	NOUN
cusj-10288	51	9	can	can	AUX
cusj-10288	51	10	vary	vary	VERB
cusj-10288	51	11	a	a	DET
cusj-10288	51	12	lot	lot	NOUN
cusj-10288	51	13	,	,	PUNCT
cusj-10288	51	14	and	and	CCONJ
cusj-10288	51	15	this	this	PRON
cusj-10288	51	16	can	can	AUX
cusj-10288	51	17	affect	affect	VERB
cusj-10288	51	18	how	how	SCONJ
cusj-10288	51	19	the	the	DET
cusj-10288	51	20	protein	protein	NOUN
cusj-10288	51	21	works	work	VERB
cusj-10288	51	22	and	and	CCONJ
cusj-10288	51	23	how	how	SCONJ
cusj-10288	51	24	easily	easily	ADV
cusj-10288	51	25	it	it	PRON
cusj-10288	51	26	dissolves	dissolve	VERB
cusj-10288	51	27	in	in	ADP
cusj-10288	51	28	water	water	NOUN
cusj-10288	52	1	[	[	X
cusj-10288	52	2	27,30	27,30	X
cusj-10288	52	3	]	]	X
cusj-10288	52	4	.	.	PUNCT
cusj-10288	53	1	in	in	ADP
cusj-10288	53	2	most	most	ADJ
cusj-10288	53	3	people	people	NOUN
cusj-10288	53	4	,	,	PUNCT
cusj-10288	53	5	the	the	DET
cusj-10288	53	6	polyq	polyq	NOUN
cusj-10288	53	7	tract	tract	NOUN
cusj-10288	53	8	has	have	VERB
cusj-10288	53	9	around	around	ADV
cusj-10288	53	10	20	20	NUM
cusj-10288	53	11	glutamines	glutamine	NOUN
cusj-10288	53	12	,	,	PUNCT
cusj-10288	53	13	but	but	CCONJ
cusj-10288	53	14	in	in	ADP
cusj-10288	53	15	some	some	DET
cusj-10288	53	16	people	people	NOUN
cusj-10288	53	17	,	,	PUNCT
cusj-10288	53	18	it	it	PRON
cusj-10288	53	19	can	can	AUX
cusj-10288	53	20	have	have	VERB
cusj-10288	53	21	more	more	ADJ
cusj-10288	53	22	than	than	ADP
cusj-10288	53	23	40	40	NUM
cusj-10288	53	24	glutamines	glutamine	NOUN
cusj-10288	53	25	,	,	PUNCT
cusj-10288	53	26	and	and	CCONJ
cusj-10288	53	27	this	this	PRON
cusj-10288	53	28	can	can	AUX
cusj-10288	53	29	cause	cause	VERB
cusj-10288	53	30	a	a	DET
cusj-10288	53	31	brain	brain	NOUN
cusj-10288	53	32	disease	disease	NOUN
cusj-10288	53	33	called	call	VERB
cusj-10288	53	34	huntington	huntington	PROPN
cusj-10288	53	35	's	's	PART
cusj-10288	53	36	disease	disease	NOUN
cusj-10288	53	37	(	(	PUNCT
cusj-10288	53	38	hd	hd	NOUN
cusj-10288	53	39	)	)	PUNCT
cusj-10288	54	1	[	[	X
cusj-10288	54	2	20,21,22	20,21,22	NUM
cusj-10288	54	3	]	]	X
cusj-10288	54	4	.	.	PUNCT
cusj-10288	55	1	the	the	DET
cusj-10288	55	2	polyq	polyq	NOUN
cusj-10288	55	3	tract	tract	NOUN
cusj-10288	55	4	is	be	AUX
cusj-10288	55	5	surrounded	surround	VERB
cusj-10288	55	6	by	by	ADP
cusj-10288	55	7	another	another	DET
cusj-10288	55	8	region	region	NOUN
cusj-10288	55	9	that	that	PRON
cusj-10288	55	10	has	have	VERB
cusj-10288	55	11	many	many	ADJ
cusj-10288	55	12	proline	proline	NOUN
cusj-10288	55	13	residues	residue	NOUN
cusj-10288	55	14	,	,	PUNCT
cusj-10288	55	15	which	which	PRON
cusj-10288	55	16	are	be	AUX
cusj-10288	55	17	amino	amino	ADJ
cusj-10288	55	18	acids	acid	NOUN
cusj-10288	55	19	that	that	PRON
cusj-10288	55	20	have	have	VERB
cusj-10288	55	21	a	a	DET
cusj-10288	55	22	ring	ring	NOUN
cusj-10288	55	23	-	-	PUNCT
cusj-10288	55	24	shaped	shape	VERB
cusj-10288	55	25	side	side	NOUN
cusj-10288	55	26	chain	chain	NOUN
cusj-10288	55	27	[	[	X
cusj-10288	55	28	31	31	NUM
cusj-10288	55	29	]	]	PUNCT
cusj-10288	55	30	.	.	PUNCT
cusj-10288	56	1	this	this	DET
cusj-10288	56	2	region	region	NOUN
cusj-10288	56	3	is	be	AUX
cusj-10288	56	4	called	call	VERB
cusj-10288	56	5	the	the	DET
cusj-10288	56	6	polyp	polyp	NOUN
cusj-10288	56	7	tract	tract	NOUN
cusj-10288	56	8	,	,	PUNCT
cusj-10288	56	9	and	and	CCONJ
cusj-10288	56	10	it	it	PRON
cusj-10288	56	11	helps	help	VERB
cusj-10288	56	12	the	the	DET
cusj-10288	56	13	protein	protein	NOUN
cusj-10288	56	14	to	to	PART
cusj-10288	56	15	stay	stay	VERB
cusj-10288	56	16	dissolved	dissolve	VERB
cusj-10288	56	17	in	in	ADP
cusj-10288	56	18	water	water	NOUN
cusj-10288	56	19	and	and	CCONJ
cusj-10288	56	20	to	to	PART
cusj-10288	56	21	interact	interact	VERB
cusj-10288	56	22	with	with	ADP
cusj-10288	56	23	proteins	protein	NOUN
cusj-10288	56	24	that	that	PRON
cusj-10288	56	25	are	be	AUX
cusj-10288	56	26	involved	involve	VERB
cusj-10288	56	27	in	in	ADP
cusj-10288	56	28	moving	move	VERB
cusj-10288	56	29	things	thing	NOUN
cusj-10288	56	30	inside	inside	ADP
cusj-10288	56	31	the	the	DET
cusj-10288	56	32	cell	cell	NOUN
cusj-10288	56	33	[	[	X
cusj-10288	56	34	31,32	31,32	NUM
cusj-10288	56	35	]	]	X
cusj-10288	56	36	.	.	PUNCT
cusj-10288	57	1	the	the	DET
cusj-10288	57	2	polyq	polyq	NOUN
cusj-10288	57	3	tract	tract	NOUN
cusj-10288	57	4	is	be	AUX
cusj-10288	57	5	not	not	PART
cusj-10288	57	6	present	present	ADJ
cusj-10288	57	7	in	in	ADP
cusj-10288	57	8	all	all	DET
cusj-10288	57	9	animals	animal	NOUN
cusj-10288	57	10	that	that	PRON
cusj-10288	57	11	have	have	VERB
cusj-10288	57	12	a	a	DET
cusj-10288	57	13	similar	similar	ADJ
cusj-10288	57	14	protein	protein	NOUN
cusj-10288	57	15	to	to	ADP
cusj-10288	57	16	htt	htt	NOUN
cusj-10288	57	17	,	,	PUNCT
cusj-10288	57	18	but	but	CCONJ
cusj-10288	57	19	it	it	PRON
cusj-10288	57	20	is	be	AUX
cusj-10288	57	21	very	very	ADV
cusj-10288	57	22	important	important	ADJ
cusj-10288	57	23	for	for	ADP
cusj-10288	57	24	the	the	DET
cusj-10288	57	25	brain	brain	NOUN
cusj-10288	57	26	functions	function	NOUN
cusj-10288	57	27	of	of	ADP
cusj-10288	57	28	animals	animal	NOUN
cusj-10288	57	29	that	that	PRON
cusj-10288	57	30	have	have	VERB
cusj-10288	57	31	it	it	PRON
cusj-10288	57	32	,	,	PUNCT
cusj-10288	57	33	columbia	columbia	PROPN
cusj-10288	57	34	undergraduate	undergraduate	PROPN
cusj-10288	57	35	science	science	PROPN
cusj-10288	57	36	journal	journal	PROPN
cusj-10288	57	37	vol	vol	NOUN
cusj-10288	57	38	.	.	PROPN
cusj-10288	57	39	17	17	NUM
cusj-10288	57	40	,	,	PUNCT
cusj-10288	57	41	2023	2023	NUM
cusj-10288	57	42	datta	datta	NOUN
cusj-10288	57	43	19	19	NUM
cusj-10288	57	44	as	as	SCONJ
cusj-10288	57	45	shown	show	VERB
cusj-10288	57	46	by	by	ADP
cusj-10288	57	47	experiments	experiment	NOUN
cusj-10288	57	48	with	with	ADP
cusj-10288	57	49	mice	mouse	NOUN
cusj-10288	57	50	that	that	PRON
cusj-10288	57	51	do	do	AUX
cusj-10288	57	52	not	not	PART
cusj-10288	57	53	have	have	VERB
cusj-10288	57	54	the	the	DET
cusj-10288	57	55	polyq	polyq	NOUN
cusj-10288	57	56	tract	tract	NOUN
cusj-10288	57	57	[	[	X
cusj-10288	57	58	2,29	2,29	X
cusj-10288	57	59	]	]	X
cusj-10288	57	60	.	.	PUNCT
cusj-10288	58	1	the	the	DET
cusj-10288	58	2	polyq	polyq	NOUN
cusj-10288	58	3	tract	tract	NOUN
cusj-10288	58	4	can	can	AUX
cusj-10288	58	5	also	also	ADV
cusj-10288	58	6	form	form	VERB
cusj-10288	58	7	structures	structure	NOUN
cusj-10288	58	8	that	that	PRON
cusj-10288	58	9	look	look	VERB
cusj-10288	58	10	like	like	ADP
cusj-10288	58	11	zippers	zipper	NOUN
cusj-10288	58	12	,	,	PUNCT
cusj-10288	58	13	and	and	CCONJ
cusj-10288	58	14	these	these	DET
cusj-10288	58	15	structures	structure	NOUN
cusj-10288	58	16	can	can	AUX
cusj-10288	58	17	bind	bind	VERB
cusj-10288	58	18	to	to	ADP
cusj-10288	58	19	other	other	ADJ
cusj-10288	58	20	parts	part	NOUN
cusj-10288	58	21	of	of	ADP
cusj-10288	58	22	the	the	DET
cusj-10288	58	23	protein	protein	NOUN
cusj-10288	58	24	or	or	CCONJ
cusj-10288	58	25	to	to	ADP
cusj-10288	58	26	other	other	ADJ
cusj-10288	58	27	proteins	protein	NOUN
cusj-10288	58	28	that	that	PRON
cusj-10288	58	29	have	have	VERB
cusj-10288	58	30	similar	similar	ADJ
cusj-10288	58	31	structures	structure	NOUN
cusj-10288	58	32	[	[	X
cusj-10288	58	33	2,28	2,28	X
cusj-10288	58	34	]	]	X
cusj-10288	58	35	.	.	PUNCT
cusj-10288	59	1	the	the	DET
cusj-10288	59	2	htt	htt	NOUN
cusj-10288	59	3	protein	protein	NOUN
cusj-10288	59	4	is	be	AUX
cusj-10288	59	5	therefore	therefore	ADV
cusj-10288	59	6	a	a	DET
cusj-10288	59	7	very	very	ADV
cusj-10288	59	8	complex	complex	ADJ
cusj-10288	59	9	and	and	CCONJ
cusj-10288	59	10	versatile	versatile	ADJ
cusj-10288	59	11	protein	protein	NOUN
cusj-10288	59	12	that	that	PRON
cusj-10288	59	13	is	be	AUX
cusj-10288	59	14	involved	involve	VERB
cusj-10288	59	15	in	in	ADP
cusj-10288	59	16	many	many	ADJ
cusj-10288	59	17	different	different	ADJ
cusj-10288	59	18	processes	process	NOUN
cusj-10288	59	19	in	in	ADP
cusj-10288	59	20	the	the	DET
cusj-10288	59	21	cell	cell	NOUN
cusj-10288	59	22	.	.	PUNCT
cusj-10288	60	1	the	the	DET
cusj-10288	60	2	way	way	NOUN
cusj-10288	60	3	that	that	PRON
cusj-10288	60	4	hd	hd	PROPN
cusj-10288	60	5	is	be	AUX
cusj-10288	60	6	inherited	inherit	VERB
cusj-10288	60	7	and	and	CCONJ
cusj-10288	60	8	how	how	SCONJ
cusj-10288	60	9	it	it	PRON
cusj-10288	60	10	affects	affect	VERB
cusj-10288	60	11	different	different	ADJ
cusj-10288	60	12	people	people	NOUN
cusj-10288	60	13	is	be	AUX
cusj-10288	60	14	related	relate	VERB
cusj-10288	60	15	to	to	ADP
cusj-10288	60	16	the	the	DET
cusj-10288	60	17	way	way	NOUN
cusj-10288	60	18	that	that	PRON
cusj-10288	60	19	the	the	DET
cusj-10288	60	20	polyq	polyq	NOUN
cusj-10288	60	21	tract	tract	NOUN
cusj-10288	60	22	can	can	AUX
cusj-10288	60	23	change	change	VERB
cusj-10288	60	24	in	in	ADP
cusj-10288	60	25	size	size	NOUN
cusj-10288	60	26	and	and	CCONJ
cusj-10288	60	27	cause	cause	VERB
cusj-10288	60	28	problems	problem	NOUN
cusj-10288	60	29	,	,	PUNCT
cusj-10288	60	30	which	which	PRON
cusj-10288	60	31	is	be	AUX
cusj-10288	60	32	caused	cause	VERB
cusj-10288	60	33	by	by	ADP
cusj-10288	60	34	an	an	DET
cusj-10288	60	35	increase	increase	NOUN
cusj-10288	60	36	of	of	ADP
cusj-10288	60	37	the	the	DET
cusj-10288	60	38	number	number	NOUN
cusj-10288	60	39	of	of	ADP
cusj-10288	60	40	repeats	repeat	NOUN
cusj-10288	60	41	of	of	ADP
cusj-10288	60	42	three	three	NUM
cusj-10288	60	43	nucleic	nucleic	ADJ
cusj-10288	60	44	acids	acid	NOUN
cusj-10288	60	45	(	(	PUNCT
cusj-10288	60	46	c	c	NOUN
cusj-10288	60	47	,	,	PUNCT
cusj-10288	60	48	a	a	PRON
cusj-10288	60	49	,	,	PUNCT
cusj-10288	60	50	and	and	CCONJ
cusj-10288	60	51	g	g	NOUN
cusj-10288	60	52	)	)	PUNCT
cusj-10288	60	53	in	in	ADP
cusj-10288	60	54	the	the	DET
cusj-10288	60	55	first	first	ADJ
cusj-10288	60	56	exon	exon	NOUN
cusj-10288	60	57	of	of	ADP
cusj-10288	60	58	the	the	DET
cusj-10288	60	59	hd	hd	NOUN
cusj-10288	60	60	gene	gene	NOUN
cusj-10288	60	61	,	,	PUNCT
cusj-10288	60	62	which	which	PRON
cusj-10288	60	63	is	be	AUX
cusj-10288	60	64	located	locate	VERB
cusj-10288	60	65	on	on	ADP
cusj-10288	60	66	chromosome	chromosome	NOUN
cusj-10288	60	67	4p16.32	4p16.32	NUM
cusj-10288	61	1	[	[	X
cusj-10288	61	2	19	19	NUM
cusj-10288	61	3	]	]	PUNCT
cusj-10288	61	4	.	.	PUNCT
cusj-10288	62	1	htt	htt	NOUN
cusj-10288	62	2	has	have	VERB
cusj-10288	62	3	various	various	ADJ
cusj-10288	62	4	features	feature	NOUN
cusj-10288	62	5	that	that	PRON
cusj-10288	62	6	allow	allow	VERB
cusj-10288	62	7	it	it	PRON
cusj-10288	62	8	to	to	PART
cusj-10288	62	9	move	move	VERB
cusj-10288	62	10	between	between	ADP
cusj-10288	62	11	the	the	DET
cusj-10288	62	12	nucleus	nucleus	NOUN
cusj-10288	62	13	and	and	CCONJ
cusj-10288	62	14	the	the	DET
cusj-10288	62	15	cytoplasm	cytoplasm	NOUN
cusj-10288	62	16	of	of	ADP
cusj-10288	62	17	the	the	DET
cusj-10288	62	18	cell	cell	NOUN
cusj-10288	62	19	[	[	X
cusj-10288	62	20	2	2	NUM
cusj-10288	62	21	]	]	PUNCT
cusj-10288	62	22	.	.	PUNCT
cusj-10288	63	1	it	it	PRON
cusj-10288	63	2	has	have	VERB
cusj-10288	63	3	a	a	DET
cusj-10288	63	4	nuclear	nuclear	ADJ
cusj-10288	63	5	export	export	NOUN
cusj-10288	63	6	signal	signal	NOUN
cusj-10288	63	7	(	(	PUNCT
cusj-10288	63	8	nes	ne	NOUN
cusj-10288	63	9	)	)	PUNCT
cusj-10288	63	10	at	at	ADP
cusj-10288	63	11	the	the	DET
cusj-10288	63	12	end	end	NOUN
cusj-10288	63	13	of	of	ADP
cusj-10288	63	14	its	its	PRON
cusj-10288	63	15	c	c	NOUN
cusj-10288	63	16	-	-	PUNCT
cusj-10288	63	17	terminal	terminal	ADJ
cusj-10288	63	18	domain	domain	NOUN
cusj-10288	63	19	,	,	PUNCT
cusj-10288	63	20	which	which	PRON
cusj-10288	63	21	enables	enable	VERB
cusj-10288	63	22	it	it	PRON
cusj-10288	63	23	to	to	PART
cusj-10288	63	24	exit	exit	VERB
cusj-10288	63	25	the	the	DET
cusj-10288	63	26	nucleus	nucleus	NOUN
cusj-10288	64	1	[	[	X
cusj-10288	64	2	33	33	NUM
cusj-10288	64	3	]	]	PUNCT
cusj-10288	64	4	.	.	PUNCT
cusj-10288	65	1	it	it	PRON
cusj-10288	65	2	also	also	ADV
cusj-10288	65	3	has	have	VERB
cusj-10288	65	4	a	a	DET
cusj-10288	65	5	domain	domain	NOUN
cusj-10288	65	6	at	at	ADP
cusj-10288	65	7	the	the	DET
cusj-10288	65	8	beginning	beginning	NOUN
cusj-10288	65	9	of	of	ADP
cusj-10288	65	10	its	its	PRON
cusj-10288	65	11	nterminal	nterminal	ADJ
cusj-10288	65	12	domain	domain	NOUN
cusj-10288	65	13	,	,	PUNCT
cusj-10288	65	14	which	which	PRON
cusj-10288	65	15	consists	consist	VERB
cusj-10288	65	16	of	of	ADP
cusj-10288	65	17	18	18	NUM
cusj-10288	65	18	amino	amino	ADJ
cusj-10288	65	19	acids	acid	NOUN
cusj-10288	65	20	and	and	CCONJ
cusj-10288	65	21	interacts	interact	VERB
cusj-10288	65	22	with	with	ADP
cusj-10288	65	23	tpr	tpr	NOUN
cusj-10288	65	24	,	,	PUNCT
cusj-10288	65	25	a	a	DET
cusj-10288	65	26	protein	protein	NOUN
cusj-10288	65	27	that	that	PRON
cusj-10288	65	28	is	be	AUX
cusj-10288	65	29	part	part	NOUN
cusj-10288	65	30	of	of	ADP
cusj-10288	65	31	the	the	DET
cusj-10288	65	32	nuclear	nuclear	ADJ
cusj-10288	65	33	pore	pore	ADJ
cusj-10288	65	34	complex	complex	NOUN
cusj-10288	65	35	and	and	CCONJ
cusj-10288	65	36	facilitates	facilitate	VERB
cusj-10288	65	37	nuclear	nuclear	ADJ
cusj-10288	65	38	import	import	NOUN
cusj-10288	65	39	[	[	X
cusj-10288	65	40	33	33	NUM
cusj-10288	65	41	]	]	PUNCT
cusj-10288	65	42	.	.	PUNCT
cusj-10288	66	1	this	this	DET
cusj-10288	66	2	domain	domain	NOUN
cusj-10288	66	3	also	also	ADV
cusj-10288	66	4	forms	form	VERB
cusj-10288	66	5	a	a	DET
cusj-10288	66	6	membrane	membrane	NOUN
cusj-10288	66	7	-	-	PUNCT
cusj-10288	66	8	binding	bind	VERB
cusj-10288	66	9	domain	domain	NOUN
cusj-10288	66	10	that	that	PRON
cusj-10288	66	11	has	have	VERB
cusj-10288	66	12	an	an	DET
cusj-10288	66	13	amphipathic	amphipathic	ADJ
cusj-10288	66	14	alpha	alpha	NOUN
cusj-10288	66	15	helical	helical	ADJ
cusj-10288	66	16	structure	structure	NOUN
cusj-10288	66	17	and	and	CCONJ
cusj-10288	66	18	can	can	AUX
cusj-10288	66	19	reversibly	reversibly	ADV
cusj-10288	66	20	bind	bind	VERB
cusj-10288	66	21	to	to	ADP
cusj-10288	66	22	different	different	ADJ
cusj-10288	66	23	types	type	NOUN
cusj-10288	66	24	of	of	ADP
cusj-10288	66	25	vesicles	vesicle	NOUN
cusj-10288	66	26	,	,	PUNCT
cusj-10288	66	27	such	such	ADJ
cusj-10288	66	28	as	as	ADP
cusj-10288	66	29	those	those	PRON
cusj-10288	66	30	derived	derive	VERB
cusj-10288	66	31	from	from	ADP
cusj-10288	66	32	the	the	DET
cusj-10288	66	33	endoplasmic	endoplasmic	ADJ
cusj-10288	66	34	reticulum	reticulum	NOUN
cusj-10288	66	35	(	(	PUNCT
cusj-10288	66	36	er	er	INTJ
cusj-10288	66	37	)	)	PUNCT
cusj-10288	66	38	,	,	PUNCT
cusj-10288	66	39	endosomes	endosome	VERB
cusj-10288	66	40	,	,	PUNCT
cusj-10288	66	41	and	and	CCONJ
cusj-10288	66	42	autophagosomes	autophagosome	VERB
cusj-10288	66	43	[	[	X
cusj-10288	66	44	34	34	NUM
cusj-10288	66	45	]	]	PUNCT
cusj-10288	66	46	.	.	PUNCT
cusj-10288	67	1	this	this	DET
cusj-10288	67	2	domain	domain	NOUN
cusj-10288	67	3	is	be	AUX
cusj-10288	67	4	essential	essential	ADJ
cusj-10288	67	5	for	for	ADP
cusj-10288	67	6	the	the	DET
cusj-10288	67	7	normal	normal	ADJ
cusj-10288	67	8	function	function	NOUN
cusj-10288	67	9	of	of	ADP
cusj-10288	67	10	htt	htt	NOUN
cusj-10288	67	11	,	,	PUNCT
cusj-10288	67	12	as	as	ADP
cusj-10288	67	13	mutations	mutation	NOUN
cusj-10288	67	14	or	or	CCONJ
cusj-10288	67	15	deletions	deletion	NOUN
cusj-10288	67	16	in	in	ADP
cusj-10288	67	17	this	this	DET
cusj-10288	67	18	region	region	NOUN
cusj-10288	67	19	cause	cause	VERB
cusj-10288	67	20	htt	htt	NOUN
cusj-10288	67	21	to	to	PART
cusj-10288	67	22	accumulate	accumulate	VERB
cusj-10288	67	23	in	in	ADP
cusj-10288	67	24	the	the	DET
cusj-10288	67	25	nucleus	nucleus	NOUN
cusj-10288	67	26	and	and	CCONJ
cusj-10288	67	27	induce	induce	VERB
cusj-10288	67	28	cellular	cellular	ADJ
cusj-10288	67	29	toxicity	toxicity	NOUN
cusj-10288	67	30	[	[	X
cusj-10288	67	31	33	33	NUM
cusj-10288	67	32	]	]	PUNCT
cusj-10288	67	33	.	.	PUNCT
cusj-10288	68	1	htt	htt	NOUN
cusj-10288	68	2	is	be	AUX
cusj-10288	68	3	also	also	ADV
cusj-10288	68	4	subject	subject	ADJ
cusj-10288	68	5	to	to	ADP
cusj-10288	68	6	proteolytic	proteolytic	ADJ
cusj-10288	68	7	cleavage	cleavage	NOUN
cusj-10288	68	8	by	by	ADP
cusj-10288	68	9	various	various	ADJ
cusj-10288	68	10	enzymes	enzyme	NOUN
cusj-10288	68	11	,	,	PUNCT
cusj-10288	68	12	such	such	ADJ
cusj-10288	68	13	as	as	ADP
cusj-10288	68	14	caspases	caspase	NOUN
cusj-10288	68	15	and	and	CCONJ
cusj-10288	68	16	calpains	calpain	NOUN
cusj-10288	68	17	,	,	PUNCT
cusj-10288	68	18	which	which	PRON
cusj-10288	68	19	are	be	AUX
cusj-10288	68	20	conserved	conserve	VERB
cusj-10288	68	21	among	among	ADP
cusj-10288	68	22	higher	high	ADJ
cusj-10288	68	23	vertebrates	vertebrate	NOUN
cusj-10288	68	24	[	[	X
cusj-10288	68	25	35	35	NUM
cusj-10288	68	26	]	]	PUNCT
cusj-10288	68	27	.	.	PUNCT
cusj-10288	69	1	these	these	DET
cusj-10288	69	2	enzymes	enzyme	NOUN
cusj-10288	69	3	generate	generate	VERB
cusj-10288	69	4	fragments	fragment	NOUN
cusj-10288	69	5	of	of	ADP
cusj-10288	69	6	htt	htt	NOUN
cusj-10288	69	7	that	that	PRON
cusj-10288	69	8	are	be	AUX
cusj-10288	69	9	found	find	VERB
cusj-10288	69	10	in	in	ADP
cusj-10288	69	11	the	the	DET
cusj-10288	69	12	nucleus	nucleus	NOUN
cusj-10288	69	13	,	,	PUNCT
cusj-10288	69	14	but	but	CCONJ
cusj-10288	69	15	their	their	PRON
cusj-10288	69	16	role	role	NOUN
cusj-10288	69	17	is	be	AUX
cusj-10288	69	18	unclear	unclear	ADJ
cusj-10288	69	19	.	.	PUNCT
cusj-10288	70	1	the	the	DET
cusj-10288	70	2	proteolysis	proteolysis	NOUN
cusj-10288	70	3	of	of	ADP
cusj-10288	70	4	htt	htt	NOUN
cusj-10288	70	5	is	be	AUX
cusj-10288	70	6	influenced	influence	VERB
cusj-10288	70	7	by	by	ADP
cusj-10288	70	8	the	the	DET
cusj-10288	70	9	cellular	cellular	ADJ
cusj-10288	70	10	context	context	NOUN
cusj-10288	70	11	,	,	PUNCT
cusj-10288	70	12	as	as	SCONJ
cusj-10288	70	13	it	it	PRON
cusj-10288	70	14	is	be	AUX
cusj-10288	70	15	increased	increase	VERB
cusj-10288	70	16	in	in	ADP
cusj-10288	70	17	diseased	diseased	ADJ
cusj-10288	70	18	brains	brain	NOUN
cusj-10288	70	19	and	and	CCONJ
cusj-10288	70	20	more	more	ADV
cusj-10288	70	21	selective	selective	ADJ
cusj-10288	70	22	for	for	ADP
cusj-10288	70	23	the	the	DET
cusj-10288	70	24	fragments	fragment	NOUN
cusj-10288	70	25	that	that	PRON
cusj-10288	70	26	have	have	VERB
cusj-10288	70	27	the	the	DET
cusj-10288	70	28	nand	nand	NOUN
cusj-10288	70	29	c	c	NOUN
cusj-10288	70	30	-	-	PUNCT
cusj-10288	70	31	terminal	terminal	ADJ
cusj-10288	70	32	domains	domain	NOUN
cusj-10288	70	33	,	,	PUNCT
cusj-10288	70	34	especially	especially	ADV
cusj-10288	70	35	in	in	ADP
cusj-10288	70	36	the	the	DET
cusj-10288	70	37	striatum	striatum	NOUN
cusj-10288	70	38	[	[	X
cusj-10288	70	39	2,36	2,36	X
cusj-10288	70	40	]	]	PUNCT
cusj-10288	70	41	.	.	PUNCT
cusj-10288	71	1	another	another	DET
cusj-10288	71	2	enzyme	enzyme	NOUN
cusj-10288	71	3	that	that	PRON
cusj-10288	71	4	can	can	AUX
cusj-10288	71	5	produce	produce	VERB
cusj-10288	71	6	n	n	CCONJ
cusj-10288	71	7	-	-	PUNCT
cusj-10288	71	8	terminal	terminal	ADJ
cusj-10288	71	9	fragments	fragment	NOUN
cusj-10288	71	10	of	of	ADP
cusj-10288	71	11	htt	htt	NOUN
cusj-10288	71	12	is	be	AUX
cusj-10288	71	13	cathepsin	cathepsin	NOUN
cusj-10288	71	14	,	,	PUNCT
cusj-10288	71	15	which	which	PRON
cusj-10288	71	16	belongs	belong	VERB
cusj-10288	71	17	to	to	ADP
cusj-10288	71	18	the	the	DET
cusj-10288	71	19	lysosomal	lysosomal	ADJ
cusj-10288	71	20	degradation	degradation	NOUN
cusj-10288	71	21	pathway	pathway	NOUN
cusj-10288	72	1	[	[	X
cusj-10288	72	2	37	37	NUM
cusj-10288	72	3	]	]	PUNCT
cusj-10288	72	4	.	.	PUNCT
cusj-10288	73	1	htt	htt	NOUN
cusj-10288	73	2	can	can	AUX
cusj-10288	73	3	also	also	ADV
cusj-10288	73	4	undergo	undergo	VERB
cusj-10288	73	5	different	different	ADJ
cusj-10288	73	6	types	type	NOUN
cusj-10288	73	7	of	of	ADP
cusj-10288	73	8	posttranslational	posttranslational	ADJ
cusj-10288	73	9	modifications	modification	NOUN
cusj-10288	73	10	in	in	ADP
cusj-10288	73	11	its	its	PRON
cusj-10288	73	12	n	n	CCONJ
cusj-10288	73	13	-	-	PUNCT
cusj-10288	73	14	terminal	terminal	ADJ
cusj-10288	73	15	region	region	NOUN
cusj-10288	73	16	,	,	PUNCT
cusj-10288	73	17	such	such	ADJ
cusj-10288	73	18	as	as	ADP
cusj-10288	73	19	ubiquitination	ubiquitination	NOUN
cusj-10288	73	20	,	,	PUNCT
cusj-10288	73	21	sumoylation	sumoylation	NOUN
cusj-10288	73	22	,	,	PUNCT
cusj-10288	73	23	and	and	CCONJ
cusj-10288	73	24	phosphorylation	phosphorylation	NOUN
cusj-10288	73	25	by	by	ADP
cusj-10288	73	26	kinases	kinase	NOUN
cusj-10288	73	27	like	like	ADP
cusj-10288	73	28	akt	akt	PROPN
cusj-10288	73	29	,	,	PUNCT
cusj-10288	73	30	erk1	erk1	PROPN
cusj-10288	73	31	,	,	PUNCT
cusj-10288	73	32	and	and	CCONJ
cusj-10288	73	33	cdk5	cdk5	PROPN
cusj-10288	74	1	[	[	X
cusj-10288	74	2	2,38	2,38	X
cusj-10288	74	3	]	]	X
cusj-10288	74	4	.	.	PUNCT
cusj-10288	75	1	the	the	DET
cusj-10288	75	2	phosphorylation	phosphorylation	NOUN
cusj-10288	75	3	level	level	NOUN
cusj-10288	75	4	of	of	ADP
cusj-10288	75	5	htt	htt	NOUN
cusj-10288	75	6	is	be	AUX
cusj-10288	75	7	regulated	regulate	VERB
cusj-10288	75	8	by	by	ADP
cusj-10288	75	9	s	s	PROPN
cusj-10288	75	10	/	/	SYM
cusj-10288	75	11	t	t	PROPN
cusj-10288	75	12	phosphatases	phosphatase	NOUN
cusj-10288	75	13	pp1	pp1	NOUN
cusj-10288	75	14	and	and	CCONJ
cusj-10288	75	15	pp2a	pp2a	PROPN
cusj-10288	75	16	[	[	X
cusj-10288	75	17	39	39	NUM
cusj-10288	75	18	]	]	PUNCT
cusj-10288	75	19	.	.	PUNCT
cusj-10288	76	1	furthermore	furthermore	ADV
cusj-10288	76	2	,	,	PUNCT
cusj-10288	76	3	htt	htt	NOUN
cusj-10288	76	4	can	can	AUX
cusj-10288	76	5	be	be	AUX
cusj-10288	76	6	palmitoylated	palmitoylate	VERB
cusj-10288	76	7	in	in	ADP
cusj-10288	76	8	its	its	PRON
cusj-10288	76	9	n	n	CCONJ
cusj-10288	76	10	-	-	PUNCT
cusj-10288	76	11	terminal	terminal	ADJ
cusj-10288	76	12	region	region	NOUN
cusj-10288	76	13	through	through	ADP
cusj-10288	76	14	the	the	DET
cusj-10288	76	15	interaction	interaction	NOUN
cusj-10288	76	16	with	with	ADP
cusj-10288	76	17	huntingtin	huntingtin	NOUN
cusj-10288	76	18	-	-	PUNCT
cusj-10288	76	19	interacting	interact	VERB
cusj-10288	76	20	protein	protein	NOUN
cusj-10288	76	21	14	14	NUM
cusj-10288	76	22	(	(	PUNCT
cusj-10288	76	23	hip	hip	NOUN
cusj-10288	76	24	14	14	NUM
cusj-10288	76	25	)	)	PUNCT
cusj-10288	77	1	[	[	X
cusj-10288	77	2	40	40	NUM
cusj-10288	77	3	]	]	PUNCT
cusj-10288	77	4	.	.	PUNCT
cusj-10288	78	1	palmitoylation	palmitoylation	NOUN
cusj-10288	78	2	is	be	AUX
cusj-10288	78	3	a	a	DET
cusj-10288	78	4	mechanism	mechanism	NOUN
cusj-10288	78	5	that	that	PRON
cusj-10288	78	6	is	be	AUX
cusj-10288	78	7	used	use	VERB
cusj-10288	78	8	by	by	ADP
cusj-10288	78	9	several	several	ADJ
cusj-10288	78	10	proteins	protein	NOUN
cusj-10288	78	11	that	that	PRON
cusj-10288	78	12	are	be	AUX
cusj-10288	78	13	involved	involve	VERB
cusj-10288	78	14	in	in	ADP
cusj-10288	78	15	vesicle	vesicle	NOUN
cusj-10288	78	16	trafficking	traffic	VERB
cusj-10288	78	17	to	to	PART
cusj-10288	78	18	maintain	maintain	VERB
cusj-10288	78	19	their	their	PRON
cusj-10288	78	20	proximity	proximity	NOUN
cusj-10288	78	21	to	to	ADP
cusj-10288	78	22	the	the	DET
cusj-10288	78	23	plasma	plasma	NOUN
cusj-10288	78	24	membrane	membrane	NOUN
cusj-10288	78	25	[	[	X
cusj-10288	78	26	2	2	NUM
cusj-10288	78	27	]	]	PUNCT
cusj-10288	78	28	.	.	PUNCT
cusj-10288	79	1	htt	htt	NOUN
cusj-10288	79	2	is	be	AUX
cusj-10288	79	3	highly	highly	ADV
cusj-10288	79	4	expressed	express	VERB
cusj-10288	79	5	in	in	ADP
cusj-10288	79	6	the	the	DET
cusj-10288	79	7	human	human	ADJ
cusj-10288	79	8	brain	brain	NOUN
cusj-10288	79	9	and	and	CCONJ
cusj-10288	79	10	testes	testis	NOUN
cusj-10288	79	11	[	[	X
cusj-10288	79	12	41	41	NUM
cusj-10288	79	13	]	]	PUNCT
cusj-10288	79	14	.	.	PUNCT
cusj-10288	80	1	in	in	ADP
cusj-10288	80	2	the	the	DET
cusj-10288	80	3	brain	brain	NOUN
cusj-10288	80	4	,	,	PUNCT
cusj-10288	80	5	it	it	PRON
cusj-10288	80	6	is	be	AUX
cusj-10288	80	7	present	present	ADJ
cusj-10288	80	8	in	in	ADP
cusj-10288	80	9	both	both	DET
cusj-10288	80	10	neurons	neuron	NOUN
cusj-10288	80	11	and	and	CCONJ
cusj-10288	80	12	glial	glial	ADJ
cusj-10288	80	13	cells	cell	NOUN
cusj-10288	80	14	[	[	X
cusj-10288	80	15	42	42	NUM
cusj-10288	80	16	]	]	PUNCT
cusj-10288	80	17	.	.	PUNCT
cusj-10288	81	1	htt	htt	NOUN
cusj-10288	81	2	has	have	VERB
cusj-10288	81	3	a	a	DET
cusj-10288	81	4	complex	complex	ADJ
cusj-10288	81	5	subcellular	subcellular	ADJ
cusj-10288	81	6	localization	localization	NOUN
cusj-10288	81	7	pattern	pattern	NOUN
cusj-10288	81	8	,	,	PUNCT
cusj-10288	81	9	which	which	PRON
cusj-10288	81	10	may	may	AUX
cusj-10288	81	11	depend	depend	VERB
cusj-10288	81	12	on	on	ADP
cusj-10288	81	13	its	its	PRON
cusj-10288	81	14	conformational	conformational	ADJ
cusj-10288	81	15	state	state	NOUN
cusj-10288	81	16	,	,	PUNCT
cusj-10288	81	17	as	as	SCONJ
cusj-10288	81	18	different	different	ADJ
cusj-10288	81	19	antibodies	antibody	NOUN
cusj-10288	81	20	that	that	PRON
cusj-10288	81	21	recognize	recognize	VERB
cusj-10288	81	22	different	different	ADJ
cusj-10288	81	23	epitopes	epitope	NOUN
cusj-10288	81	24	within	within	ADP
cusj-10288	81	25	the	the	DET
cusj-10288	81	26	protein	protein	NOUN
cusj-10288	81	27	show	show	VERB
cusj-10288	81	28	different	different	ADJ
cusj-10288	81	29	subcellular	subcellular	ADJ
cusj-10288	81	30	staining	stain	VERB
cusj-10288	81	31	profiles	profile	NOUN
cusj-10288	81	32	[	[	X
cusj-10288	81	33	43	43	NUM
cusj-10288	81	34	]	]	PUNCT
cusj-10288	81	35	.	.	PUNCT
cusj-10288	82	1	htt	htt	NOUN
cusj-10288	82	2	is	be	AUX
cusj-10288	82	3	not	not	PART
cusj-10288	82	4	only	only	ADV
cusj-10288	82	5	localized	localize	VERB
cusj-10288	82	6	in	in	ADP
cusj-10288	82	7	the	the	DET
cusj-10288	82	8	nucleus	nucleus	NOUN
cusj-10288	82	9	,	,	PUNCT
cusj-10288	82	10	er	er	INTJ
cusj-10288	82	11	,	,	PUNCT
cusj-10288	82	12	and	and	CCONJ
cusj-10288	82	13	golgi	golgi	PROPN
cusj-10288	82	14	complex	complex	NOUN
cusj-10288	82	15	,	,	PUNCT
cusj-10288	82	16	but	but	CCONJ
cusj-10288	82	17	also	also	ADV
cusj-10288	82	18	in	in	ADP
cusj-10288	82	19	the	the	DET
cusj-10288	82	20	axons	axon	NOUN
cusj-10288	82	21	and	and	CCONJ
cusj-10288	82	22	synapses	synapsis	NOUN
cusj-10288	82	23	of	of	ADP
cusj-10288	82	24	neurons	neuron	NOUN
cusj-10288	82	25	[	[	X
cusj-10288	82	26	41	41	NUM
cusj-10288	82	27	]	]	PUNCT
cusj-10288	82	28	,	,	PUNCT
cusj-10288	82	29	where	where	SCONJ
cusj-10288	82	30	it	it	PRON
cusj-10288	82	31	is	be	AUX
cusj-10288	82	32	associated	associate	VERB
cusj-10288	82	33	with	with	ADP
cusj-10288	82	34	microtubules	microtubule	NOUN
cusj-10288	82	35	,	,	PUNCT
cusj-10288	82	36	caveolae	caveolae	NOUN
cusj-10288	82	37	,	,	PUNCT
cusj-10288	82	38	and	and	CCONJ
cusj-10288	82	39	synaptosomes	synaptosome	NOUN
cusj-10288	83	1	[	[	X
cusj-10288	83	2	41	41	NUM
cusj-10288	83	3	]	]	PUNCT
cusj-10288	83	4	.	.	PUNCT
cusj-10288	84	1	significance	significance	NOUN
cusj-10288	84	2	and	and	CCONJ
cusj-10288	84	3	function	function	NOUN
cusj-10288	84	4	of	of	ADP
cusj-10288	84	5	the	the	DET
cusj-10288	84	6	huntingtin	huntingtin	ADJ
cusj-10288	84	7	protein	protein	NOUN
cusj-10288	84	8	the	the	DET
cusj-10288	84	9	function	function	NOUN
cusj-10288	84	10	and	and	CCONJ
cusj-10288	84	11	role	role	NOUN
cusj-10288	84	12	of	of	ADP
cusj-10288	84	13	the	the	DET
cusj-10288	84	14	huntingtin	huntingtin	ADJ
cusj-10288	84	15	protein	protein	NOUN
cusj-10288	84	16	is	be	AUX
cusj-10288	84	17	still	still	ADV
cusj-10288	84	18	unclear	unclear	ADJ
cusj-10288	84	19	,	,	PUNCT
cusj-10288	84	20	despite	despite	SCONJ
cusj-10288	84	21	the	the	DET
cusj-10288	84	22	fact	fact	NOUN
cusj-10288	84	23	that	that	SCONJ
cusj-10288	84	24	its	its	PRON
cusj-10288	84	25	genetic	genetic	ADJ
cusj-10288	84	26	location	location	NOUN
cusj-10288	84	27	was	be	AUX
cusj-10288	84	28	identified	identify	VERB
cusj-10288	84	29	a	a	DET
cusj-10288	84	30	long	long	ADJ
cusj-10288	84	31	time	time	NOUN
cusj-10288	84	32	ago	ago	ADV
cusj-10288	84	33	.	.	PUNCT
cusj-10288	85	1	some	some	DET
cusj-10288	85	2	studies	study	NOUN
cusj-10288	85	3	have	have	AUX
cusj-10288	85	4	proposed	propose	VERB
cusj-10288	85	5	that	that	SCONJ
cusj-10288	85	6	huntingtin	huntingtin	NOUN
cusj-10288	85	7	is	be	AUX
cusj-10288	85	8	involved	involve	VERB
cusj-10288	85	9	in	in	ADP
cusj-10288	85	10	regulating	regulate	VERB
cusj-10288	85	11	gene	gene	NOUN
cusj-10288	85	12	expression	expression	NOUN
cusj-10288	85	13	and	and	CCONJ
cusj-10288	85	14	transporting	transport	VERB
cusj-10288	85	15	molecules	molecule	NOUN
cusj-10288	85	16	inside	inside	ADP
cusj-10288	85	17	the	the	DET
cusj-10288	85	18	cell	cell	NOUN
cusj-10288	85	19	,	,	PUNCT
cusj-10288	85	20	based	base	VERB
cusj-10288	85	21	on	on	ADP
cusj-10288	85	22	its	its	PRON
cusj-10288	85	23	presence	presence	NOUN
cusj-10288	85	24	in	in	ADP
cusj-10288	85	25	both	both	CCONJ
cusj-10288	85	26	the	the	DET
cusj-10288	85	27	cytoplasm	cytoplasm	NOUN
cusj-10288	85	28	and	and	CCONJ
cusj-10288	85	29	the	the	DET
cusj-10288	85	30	nucleus	nucleus	NOUN
cusj-10288	85	31	and	and	CCONJ
cusj-10288	85	32	its	its	PRON
cusj-10288	85	33	frequent	frequent	ADJ
cusj-10288	85	34	interactions	interaction	NOUN
cusj-10288	85	35	with	with	ADP
cusj-10288	85	36	other	other	ADJ
cusj-10288	85	37	proteins	protein	NOUN
cusj-10288	85	38	[	[	X
cusj-10288	85	39	44	44	NUM
cusj-10288	85	40	]	]	PUNCT
cusj-10288	85	41	.	.	PUNCT
cusj-10288	86	1	the	the	DET
cusj-10288	86	2	huntingtin	huntingtin	ADJ
cusj-10288	86	3	protein	protein	NOUN
cusj-10288	86	4	also	also	ADV
cusj-10288	86	5	plays	play	VERB
cusj-10288	86	6	a	a	DET
cusj-10288	86	7	role	role	NOUN
cusj-10288	86	8	in	in	ADP
cusj-10288	86	9	neuronal	neuronal	ADJ
cusj-10288	86	10	development	development	NOUN
cusj-10288	86	11	,	,	PUNCT
cusj-10288	86	12	synaptic	synaptic	ADJ
cusj-10288	86	13	transmission	transmission	NOUN
cusj-10288	86	14	,	,	PUNCT
cusj-10288	86	15	axonal	axonal	ADJ
cusj-10288	86	16	transport	transport	NOUN
cusj-10288	86	17	,	,	PUNCT
cusj-10288	86	18	and	and	CCONJ
cusj-10288	86	19	autophagy	autophagy	NOUN
cusj-10288	86	20	[	[	X
cusj-10288	86	21	51	51	NUM
cusj-10288	86	22	]	]	PUNCT
cusj-10288	86	23	.	.	PUNCT
cusj-10288	87	1	the	the	DET
cusj-10288	87	2	huntingtin	huntingtin	PROPN
cusj-10288	87	3	columbia	columbia	PROPN
cusj-10288	87	4	undergraduate	undergraduate	PROPN
cusj-10288	87	5	science	science	PROPN
cusj-10288	87	6	journal	journal	PROPN
cusj-10288	87	7	vol	vol	NOUN
cusj-10288	87	8	.	.	PROPN
cusj-10288	87	9	17	17	NUM
cusj-10288	87	10	,	,	PUNCT
cusj-10288	87	11	2023	2023	NUM
cusj-10288	87	12	datta	datta	NOUN
cusj-10288	87	13	20	20	NUM
cusj-10288	87	14	gene	gene	NOUN
cusj-10288	87	15	has	have	VERB
cusj-10288	87	16	a	a	DET
cusj-10288	87	17	segment	segment	NOUN
cusj-10288	87	18	of	of	ADP
cusj-10288	87	19	dna	dna	NOUN
cusj-10288	87	20	that	that	PRON
cusj-10288	87	21	repeats	repeat	VERB
cusj-10288	87	22	the	the	DET
cusj-10288	87	23	sequence	sequence	NOUN
cusj-10288	87	24	cag	cag	PROPN
cusj-10288	87	25	,	,	PUNCT
cusj-10288	87	26	which	which	PRON
cusj-10288	87	27	codes	code	VERB
cusj-10288	87	28	for	for	ADP
cusj-10288	87	29	the	the	DET
cusj-10288	87	30	amino	amino	NOUN
cusj-10288	87	31	acid	acid	NOUN
cusj-10288	87	32	glutamine	glutamine	NOUN
cusj-10288	87	33	.	.	PUNCT
cusj-10288	88	1	in	in	ADP
cusj-10288	88	2	normal	normal	ADJ
cusj-10288	88	3	huntingtin	huntingtin	NOUN
cusj-10288	88	4	proteins	protein	NOUN
cusj-10288	88	5	,	,	PUNCT
cusj-10288	88	6	this	this	DET
cusj-10288	88	7	segment	segment	NOUN
cusj-10288	88	8	has	have	VERB
cusj-10288	88	9	less	less	ADJ
cusj-10288	88	10	than	than	ADP
cusj-10288	88	11	27	27	NUM
cusj-10288	88	12	repeats	repeat	NOUN
cusj-10288	88	13	,	,	PUNCT
cusj-10288	88	14	and	and	CCONJ
cusj-10288	88	15	people	people	NOUN
cusj-10288	88	16	with	with	ADP
cusj-10288	88	17	27	27	NUM
cusj-10288	88	18	to	to	PART
cusj-10288	88	19	35	35	NUM
cusj-10288	88	20	repeats	repeat	NOUN
cusj-10288	88	21	(	(	PUNCT
cusj-10288	88	22	called	call	VERB
cusj-10288	88	23	transitional	transitional	ADJ
cusj-10288	88	24	alleles	allele	NOUN
cusj-10288	88	25	)	)	PUNCT
cusj-10288	89	1	[	[	X
cusj-10288	89	2	45	45	NUM
cusj-10288	89	3	]	]	PUNCT
cusj-10288	89	4	do	do	AUX
cusj-10288	89	5	not	not	PART
cusj-10288	89	6	develop	develop	VERB
cusj-10288	89	7	the	the	DET
cusj-10288	89	8	disease	disease	NOUN
cusj-10288	89	9	,	,	PUNCT
cusj-10288	89	10	but	but	CCONJ
cusj-10288	89	11	they	they	PRON
cusj-10288	89	12	may	may	AUX
cusj-10288	89	13	pass	pass	VERB
cusj-10288	89	14	on	on	ADP
cusj-10288	89	15	longer	long	ADJ
cusj-10288	89	16	repeats	repeat	NOUN
cusj-10288	89	17	to	to	ADP
cusj-10288	89	18	their	their	PRON
cusj-10288	89	19	offspring	offspring	NOUN
cusj-10288	89	20	.	.	PUNCT
cusj-10288	90	1	people	people	NOUN
cusj-10288	90	2	with	with	ADP
cusj-10288	90	3	36	36	NUM
cusj-10288	90	4	or	or	CCONJ
cusj-10288	90	5	more	more	ADJ
cusj-10288	90	6	repeats	repeat	NOUN
cusj-10288	90	7	will	will	AUX
cusj-10288	90	8	develop	develop	VERB
cusj-10288	90	9	the	the	DET
cusj-10288	90	10	disease	disease	NOUN
cusj-10288	90	11	[	[	X
cusj-10288	90	12	46	46	NUM
cusj-10288	90	13	]	]	PUNCT
cusj-10288	90	14	.	.	PUNCT
cusj-10288	91	1	the	the	DET
cusj-10288	91	2	number	number	NOUN
cusj-10288	91	3	of	of	ADP
cusj-10288	91	4	cag	cag	PROPN
cusj-10288	91	5	repeats	repeat	NOUN
cusj-10288	91	6	tends	tend	VERB
cusj-10288	91	7	to	to	PART
cusj-10288	91	8	increase	increase	VERB
cusj-10288	91	9	in	in	ADP
cusj-10288	91	10	each	each	DET
cusj-10288	91	11	generation	generation	NOUN
cusj-10288	91	12	,	,	PUNCT
cusj-10288	91	13	which	which	PRON
cusj-10288	91	14	means	mean	VERB
cusj-10288	91	15	that	that	SCONJ
cusj-10288	91	16	the	the	DET
cusj-10288	91	17	disease	disease	NOUN
cusj-10288	91	18	becomes	become	VERB
cusj-10288	91	19	more	more	ADV
cusj-10288	91	20	severe	severe	ADJ
cusj-10288	91	21	and	and	CCONJ
cusj-10288	91	22	appears	appear	VERB
cusj-10288	91	23	earlier	early	ADV
cusj-10288	91	24	in	in	ADP
cusj-10288	91	25	life	life	NOUN
cusj-10288	91	26	.	.	PUNCT
cusj-10288	92	1	this	this	DET
cusj-10288	92	2	phenomenon	phenomenon	NOUN
cusj-10288	92	3	is	be	AUX
cusj-10288	92	4	called	call	VERB
cusj-10288	92	5	"	"	PUNCT
cusj-10288	92	6	anticipation	anticipation	NOUN
cusj-10288	92	7	"	"	PUNCT
cusj-10288	92	8	[	[	X
cusj-10288	92	9	47	47	NUM
cusj-10288	92	10	]	]	PUNCT
cusj-10288	92	11	.	.	PUNCT
cusj-10288	93	1	the	the	DET
cusj-10288	93	2	age	age	NOUN
cusj-10288	93	3	of	of	ADP
cusj-10288	93	4	onset	onset	NOUN
cusj-10288	93	5	of	of	ADP
cusj-10288	93	6	the	the	DET
cusj-10288	93	7	disease	disease	NOUN
cusj-10288	93	8	is	be	AUX
cusj-10288	93	9	inversely	inversely	ADV
cusj-10288	93	10	related	relate	VERB
cusj-10288	93	11	to	to	ADP
cusj-10288	93	12	the	the	DET
cusj-10288	93	13	number	number	NOUN
cusj-10288	93	14	of	of	ADP
cusj-10288	93	15	cag	cag	PROPN
cusj-10288	93	16	repeats	repeat	NOUN
cusj-10288	93	17	.	.	PUNCT
cusj-10288	94	1	therefore	therefore	ADV
cusj-10288	94	2	,	,	PUNCT
cusj-10288	94	3	people	people	NOUN
cusj-10288	94	4	with	with	ADP
cusj-10288	94	5	juvenileand	juvenileand	NOUN
cusj-10288	94	6	infantile	infantile	NOUN
cusj-10288	94	7	-	-	PUNCT
cusj-10288	94	8	onset	onset	NOUN
cusj-10288	94	9	hd	hd	NOUN
cusj-10288	94	10	have	have	VERB
cusj-10288	94	11	more	more	ADJ
cusj-10288	94	12	repeats	repeat	NOUN
cusj-10288	94	13	than	than	ADP
cusj-10288	94	14	their	their	PRON
cusj-10288	94	15	parents	parent	NOUN
cusj-10288	94	16	and	and	CCONJ
cusj-10288	94	17	show	show	VERB
cusj-10288	94	18	symptoms	symptom	NOUN
cusj-10288	94	19	earlier	early	ADV
cusj-10288	94	20	[	[	X
cusj-10288	94	21	48	48	NUM
cusj-10288	94	22	]	]	PUNCT
cusj-10288	94	23	.	.	PUNCT
cusj-10288	95	1	the	the	DET
cusj-10288	95	2	huntingtin	huntingtin	ADJ
cusj-10288	95	3	protein	protein	NOUN
cusj-10288	95	4	is	be	AUX
cusj-10288	95	5	expressed	express	VERB
cusj-10288	95	6	in	in	ADP
cusj-10288	95	7	many	many	ADJ
cusj-10288	95	8	different	different	ADJ
cusj-10288	95	9	types	type	NOUN
cusj-10288	95	10	of	of	ADP
cusj-10288	95	11	cells	cell	NOUN
cusj-10288	95	12	,	,	PUNCT
cusj-10288	95	13	but	but	CCONJ
cusj-10288	95	14	it	it	PRON
cusj-10288	95	15	is	be	AUX
cusj-10288	95	16	especially	especially	ADV
cusj-10288	95	17	abundant	abundant	ADJ
cusj-10288	95	18	in	in	ADP
cusj-10288	95	19	the	the	DET
cusj-10288	95	20	brain	brain	NOUN
cusj-10288	95	21	and	and	CCONJ
cusj-10288	95	22	the	the	DET
cusj-10288	95	23	testes	testis	NOUN
cusj-10288	95	24	,	,	PUNCT
cusj-10288	95	25	and	and	CCONJ
cusj-10288	95	26	to	to	ADP
cusj-10288	95	27	a	a	DET
cusj-10288	95	28	lesser	less	ADJ
cusj-10288	95	29	extent	extent	NOUN
cusj-10288	95	30	,	,	PUNCT
cusj-10288	95	31	in	in	ADP
cusj-10288	95	32	the	the	DET
cusj-10288	95	33	liver	liver	NOUN
cusj-10288	95	34	and	and	CCONJ
cusj-10288	95	35	the	the	DET
cusj-10288	95	36	lungs	lung	NOUN
cusj-10288	95	37	[	[	X
cusj-10288	95	38	49	49	NUM
cusj-10288	95	39	]	]	PUNCT
cusj-10288	95	40	.	.	PUNCT
cusj-10288	96	1	it	it	PRON
cusj-10288	96	2	has	have	VERB
cusj-10288	96	3	a	a	DET
cusj-10288	96	4	protective	protective	ADJ
cusj-10288	96	5	role	role	NOUN
cusj-10288	96	6	against	against	ADP
cusj-10288	96	7	cell	cell	NOUN
cusj-10288	96	8	death	death	NOUN
cusj-10288	96	9	,	,	PUNCT
cusj-10288	96	10	but	but	CCONJ
cusj-10288	96	11	when	when	SCONJ
cusj-10288	96	12	it	it	PRON
cusj-10288	96	13	is	be	AUX
cusj-10288	96	14	mutated	mutate	VERB
cusj-10288	96	15	or	or	CCONJ
cusj-10288	96	16	underexpressed	underexpressed	ADJ
cusj-10288	96	17	,	,	PUNCT
cusj-10288	96	18	it	it	PRON
cusj-10288	96	19	causes	cause	VERB
cusj-10288	96	20	early	early	ADJ
cusj-10288	96	21	apoptosis	apoptosis	NOUN
cusj-10288	96	22	and	and	CCONJ
cusj-10288	96	23	dysfunction	dysfunction	NOUN
cusj-10288	96	24	.	.	PUNCT
cusj-10288	97	1	the	the	DET
cusj-10288	97	2	mutation	mutation	NOUN
cusj-10288	97	3	that	that	PRON
cusj-10288	97	4	causes	cause	VERB
cusj-10288	97	5	hd	hd	NOUN
cusj-10288	97	6	is	be	AUX
cusj-10288	97	7	an	an	DET
cusj-10288	97	8	expansion	expansion	NOUN
cusj-10288	97	9	of	of	ADP
cusj-10288	97	10	the	the	DET
cusj-10288	97	11	cag	cag	PROPN
cusj-10288	97	12	repeats	repeat	NOUN
cusj-10288	97	13	,	,	PUNCT
cusj-10288	97	14	which	which	PRON
cusj-10288	97	15	results	result	VERB
cusj-10288	97	16	in	in	ADP
cusj-10288	97	17	a	a	DET
cusj-10288	97	18	longer	long	ADJ
cusj-10288	97	19	stretch	stretch	NOUN
cusj-10288	97	20	of	of	ADP
cusj-10288	97	21	glutamine	glutamine	NOUN
cusj-10288	97	22	in	in	ADP
cusj-10288	97	23	the	the	DET
cusj-10288	97	24	protein	protein	NOUN
cusj-10288	97	25	[	[	X
cusj-10288	97	26	46	46	NUM
cusj-10288	97	27	]	]	PUNCT
cusj-10288	97	28	.	.	PUNCT
cusj-10288	98	1	this	this	PRON
cusj-10288	98	2	leads	lead	VERB
cusj-10288	98	3	to	to	ADP
cusj-10288	98	4	the	the	DET
cusj-10288	98	5	formation	formation	NOUN
cusj-10288	98	6	of	of	ADP
cusj-10288	98	7	abnormal	abnormal	ADJ
cusj-10288	98	8	aggregates	aggregate	NOUN
cusj-10288	98	9	of	of	ADP
cusj-10288	98	10	the	the	DET
cusj-10288	98	11	protein	protein	NOUN
cusj-10288	98	12	in	in	ADP
cusj-10288	98	13	the	the	DET
cusj-10288	98	14	nucleus	nucleus	NOUN
cusj-10288	98	15	and	and	CCONJ
cusj-10288	98	16	the	the	DET
cusj-10288	98	17	cytoplasm	cytoplasm	NOUN
cusj-10288	98	18	of	of	ADP
cusj-10288	98	19	the	the	DET
cusj-10288	98	20	cell	cell	NOUN
cusj-10288	98	21	,	,	PUNCT
cusj-10288	98	22	which	which	PRON
cusj-10288	98	23	disrupts	disrupt	VERB
cusj-10288	98	24	the	the	DET
cusj-10288	98	25	normal	normal	ADJ
cusj-10288	98	26	balance	balance	NOUN
cusj-10288	98	27	of	of	ADP
cusj-10288	98	28	the	the	DET
cusj-10288	98	29	cell	cell	NOUN
cusj-10288	98	30	and	and	CCONJ
cusj-10288	98	31	triggers	trigger	NOUN
cusj-10288	98	32	apoptosis	apoptosis	VERB
cusj-10288	98	33	[	[	X
cusj-10288	98	34	50	50	NUM
cusj-10288	98	35	]	]	PUNCT
cusj-10288	98	36	.	.	PUNCT
cusj-10288	99	1	the	the	DET
cusj-10288	99	2	aggregates	aggregate	NOUN
cusj-10288	99	3	also	also	ADV
cusj-10288	99	4	interfere	interfere	VERB
cusj-10288	99	5	with	with	ADP
cusj-10288	99	6	the	the	DET
cusj-10288	99	7	normal	normal	ADJ
cusj-10288	99	8	function	function	NOUN
cusj-10288	99	9	of	of	ADP
cusj-10288	99	10	huntingtin	huntingtin	NOUN
cusj-10288	99	11	and	and	CCONJ
cusj-10288	99	12	its	its	PRON
cusj-10288	99	13	interacting	interact	VERB
cusj-10288	99	14	partners	partner	NOUN
cusj-10288	99	15	,	,	PUNCT
cusj-10288	99	16	leading	lead	VERB
cusj-10288	99	17	to	to	ADP
cusj-10288	99	18	neuronal	neuronal	ADJ
cusj-10288	99	19	degeneration	degeneration	NOUN
cusj-10288	99	20	,	,	PUNCT
cusj-10288	99	21	inflammation	inflammation	NOUN
cusj-10288	99	22	,	,	PUNCT
cusj-10288	99	23	oxidative	oxidative	ADJ
cusj-10288	99	24	stress	stress	NOUN
cusj-10288	99	25	,	,	PUNCT
cusj-10288	99	26	mitochondrial	mitochondrial	ADJ
cusj-10288	99	27	dysfunction	dysfunction	NOUN
cusj-10288	99	28	,	,	PUNCT
cusj-10288	99	29	and	and	CCONJ
cusj-10288	99	30	impaired	impaired	ADJ
cusj-10288	99	31	autophagy[52	autophagy[52	NOUN
cusj-10288	99	32	]	]	PUNCT
cusj-10288	99	33	.	.	PUNCT
cusj-10288	100	1	the	the	DET
cusj-10288	100	2	most	most	ADV
cusj-10288	100	3	affected	affected	ADJ
cusj-10288	100	4	brain	brain	NOUN
cusj-10288	100	5	region	region	NOUN
cusj-10288	100	6	is	be	AUX
cusj-10288	100	7	the	the	DET
cusj-10288	100	8	striatum	striatum	NOUN
cusj-10288	100	9	,	,	PUNCT
cusj-10288	100	10	which	which	PRON
cusj-10288	100	11	is	be	AUX
cusj-10288	100	12	involved	involve	VERB
cusj-10288	100	13	in	in	ADP
cusj-10288	100	14	motor	motor	NOUN
cusj-10288	100	15	control	control	NOUN
cusj-10288	100	16	and	and	CCONJ
cusj-10288	100	17	cognition	cognition	NOUN
cusj-10288	100	18	,	,	PUNCT
cusj-10288	100	19	followed	follow	VERB
cusj-10288	100	20	by	by	ADP
cusj-10288	100	21	the	the	DET
cusj-10288	100	22	cortex	cortex	NOUN
cusj-10288	100	23	,	,	PUNCT
cusj-10288	100	24	which	which	PRON
cusj-10288	100	25	is	be	AUX
cusj-10288	100	26	responsible	responsible	ADJ
cusj-10288	100	27	for	for	ADP
cusj-10288	100	28	higher	high	ADJ
cusj-10288	100	29	cognitive	cognitive	ADJ
cusj-10288	100	30	functions	function	NOUN
cusj-10288	100	31	[	[	X
cusj-10288	100	32	53	53	NUM
cusj-10288	100	33	]	]	PUNCT
cusj-10288	100	34	.	.	PUNCT
cusj-10288	101	1	the	the	DET
cusj-10288	101	2	symptoms	symptom	NOUN
cusj-10288	101	3	of	of	ADP
cusj-10288	101	4	hd	hd	PROPN
cusj-10288	101	5	include	include	VERB
cusj-10288	101	6	chorea	chorea	NOUN
cusj-10288	101	7	,	,	PUNCT
cusj-10288	101	8	dystonia	dystonia	NOUN
cusj-10288	101	9	,	,	PUNCT
cusj-10288	101	10	rigidity	rigidity	NOUN
cusj-10288	101	11	,	,	PUNCT
cusj-10288	101	12	bradykinesia	bradykinesia	PROPN
cusj-10288	101	13	,	,	PUNCT
cusj-10288	101	14	cognitive	cognitive	ADJ
cusj-10288	101	15	impairment	impairment	NOUN
cusj-10288	101	16	,	,	PUNCT
cusj-10288	101	17	and	and	CCONJ
cusj-10288	101	18	psychiatric	psychiatric	ADJ
cusj-10288	101	19	disturbances	disturbance	NOUN
cusj-10288	101	20	[	[	X
cusj-10288	101	21	54	54	NUM
cusj-10288	101	22	]	]	PUNCT
cusj-10288	101	23	.	.	PUNCT
cusj-10288	102	1	there	there	PRON
cusj-10288	102	2	is	be	VERB
cusj-10288	102	3	no	no	DET
cusj-10288	102	4	cure	cure	NOUN
cusj-10288	102	5	for	for	ADP
cusj-10288	102	6	hd	hd	NOUN
cusj-10288	102	7	,	,	PUNCT
cusj-10288	102	8	but	but	CCONJ
cusj-10288	102	9	some	some	DET
cusj-10288	102	10	treatments	treatment	NOUN
cusj-10288	102	11	can	can	AUX
cusj-10288	102	12	help	help	VERB
cusj-10288	102	13	to	to	PART
cusj-10288	102	14	manage	manage	VERB
cusj-10288	102	15	the	the	DET
cusj-10288	102	16	symptoms	symptom	NOUN
cusj-10288	102	17	and	and	CCONJ
cusj-10288	102	18	improve	improve	VERB
cusj-10288	102	19	the	the	DET
cusj-10288	102	20	quality	quality	NOUN
cusj-10288	102	21	of	of	ADP
cusj-10288	102	22	life	life	NOUN
cusj-10288	102	23	of	of	ADP
cusj-10288	102	24	the	the	DET
cusj-10288	102	25	patients	patient	NOUN
cusj-10288	102	26	[	[	X
cusj-10288	102	27	55	55	NUM
cusj-10288	102	28	]	]	PUNCT
cusj-10288	102	29	.	.	PUNCT
cusj-10288	103	1	clinical	clinical	ADJ
cusj-10288	103	2	indicators	indicator	NOUN
cusj-10288	103	3	of	of	ADP
cusj-10288	103	4	huntington	huntington	PROPN
cusj-10288	103	5	disease	disease	PROPN
cusj-10288	103	6	hd	hd	PROPN
cusj-10288	103	7	affects	affect	VERB
cusj-10288	103	8	the	the	DET
cusj-10288	103	9	different	different	ADJ
cusj-10288	103	10	aspects	aspect	NOUN
cusj-10288	103	11	of	of	ADP
cusj-10288	103	12	behaviour	behaviour	NOUN
cusj-10288	103	13	,	,	PUNCT
cusj-10288	103	14	cognition	cognition	NOUN
cusj-10288	103	15	,	,	PUNCT
cusj-10288	103	16	and	and	CCONJ
cusj-10288	103	17	motor	motor	NOUN
cusj-10288	103	18	function	function	NOUN
cusj-10288	103	19	of	of	ADP
cusj-10288	103	20	humans	human	NOUN
cusj-10288	103	21	[	[	X
cusj-10288	103	22	51	51	NUM
cusj-10288	103	23	]	]	PUNCT
cusj-10288	103	24	.	.	PUNCT
cusj-10288	104	1	the	the	DET
cusj-10288	104	2	disease	disease	NOUN
cusj-10288	104	3	has	have	VERB
cusj-10288	104	4	three	three	NUM
cusj-10288	104	5	subtypes	subtype	NOUN
cusj-10288	104	6	,	,	PUNCT
cusj-10288	104	7	depending	depend	VERB
cusj-10288	104	8	on	on	ADP
cusj-10288	104	9	the	the	DET
cusj-10288	104	10	age	age	NOUN
cusj-10288	104	11	of	of	ADP
cusj-10288	104	12	onset	onset	NOUN
cusj-10288	104	13	:	:	PUNCT
cusj-10288	104	14	adult	adult	NOUN
cusj-10288	104	15	-	-	PUNCT
cusj-10288	104	16	onset	onset	NOUN
cusj-10288	104	17	,	,	PUNCT
cusj-10288	104	18	juvenile	juvenile	NOUN
cusj-10288	104	19	-	-	PUNCT
cusj-10288	104	20	onset	onset	ADJ
cusj-10288	104	21	,	,	PUNCT
cusj-10288	104	22	and	and	CCONJ
cusj-10288	104	23	infantile	infantile	ADJ
cusj-10288	104	24	-	-	PUNCT
cusj-10288	104	25	onset	onset	NOUN
cusj-10288	104	26	.	.	PUNCT
cusj-10288	105	1	the	the	DET
cusj-10288	105	2	most	most	ADV
cusj-10288	105	3	common	common	ADJ
cusj-10288	105	4	subtype	subtype	NOUN
cusj-10288	105	5	is	be	AUX
cusj-10288	105	6	adult	adult	NOUN
cusj-10288	105	7	-	-	PUNCT
cusj-10288	105	8	onset	onset	NOUN
cusj-10288	105	9	hd	hd	NOUN
cusj-10288	105	10	,	,	PUNCT
cusj-10288	105	11	which	which	PRON
cusj-10288	105	12	usually	usually	ADV
cusj-10288	105	13	manifests	manifest	VERB
cusj-10288	105	14	in	in	ADP
cusj-10288	105	15	the	the	DET
cusj-10288	105	16	fourth	fourth	ADJ
cusj-10288	105	17	or	or	CCONJ
cusj-10288	105	18	fifth	fifth	ADJ
cusj-10288	105	19	decade	decade	NOUN
cusj-10288	105	20	of	of	ADP
cusj-10288	105	21	life	life	NOUN
cusj-10288	105	22	.	.	PUNCT
cusj-10288	106	1	patients	patient	NOUN
cusj-10288	106	2	with	with	ADP
cusj-10288	106	3	adult	adult	NOUN
cusj-10288	106	4	-	-	PUNCT
cusj-10288	106	5	onset	onset	NOUN
cusj-10288	106	6	hd	hd	NOUN
cusj-10288	106	7	experience	experience	NOUN
cusj-10288	106	8	a	a	DET
cusj-10288	106	9	range	range	NOUN
cusj-10288	106	10	of	of	ADP
cusj-10288	106	11	behavioural	behavioural	ADJ
cusj-10288	106	12	symptoms	symptom	NOUN
cusj-10288	106	13	,	,	PUNCT
cusj-10288	106	14	such	such	ADJ
cusj-10288	106	15	as	as	ADP
cusj-10288	106	16	irritability	irritability	NOUN
cusj-10288	106	17	,	,	PUNCT
cusj-10288	106	18	agitation	agitation	NOUN
cusj-10288	106	19	,	,	PUNCT
cusj-10288	106	20	loss	loss	NOUN
cusj-10288	106	21	of	of	ADP
cusj-10288	106	22	inhibition	inhibition	NOUN
cusj-10288	106	23	,	,	PUNCT
cusj-10288	106	24	and	and	CCONJ
cusj-10288	106	25	aggression	aggression	NOUN
cusj-10288	106	26	,	,	PUNCT
cusj-10288	106	27	which	which	PRON
cusj-10288	106	28	often	often	ADV
cusj-10288	106	29	precede	precede	VERB
cusj-10288	106	30	the	the	DET
cusj-10288	106	31	motor	motor	NOUN
cusj-10288	106	32	symptoms	symptom	NOUN
cusj-10288	106	33	[	[	X
cusj-10288	106	34	46,52	46,52	X
cusj-10288	106	35	]	]	PUNCT
cusj-10288	106	36	.	.	PUNCT
cusj-10288	107	1	the	the	DET
cusj-10288	107	2	motor	motor	NOUN
cusj-10288	107	3	symptoms	symptom	NOUN
cusj-10288	107	4	include	include	VERB
cusj-10288	107	5	involuntary	involuntary	ADJ
cusj-10288	107	6	movements	movement	NOUN
cusj-10288	107	7	(	(	PUNCT
cusj-10288	107	8	chorea	chorea	NOUN
cusj-10288	107	9	)	)	PUNCT
cusj-10288	107	10	,	,	PUNCT
cusj-10288	107	11	which	which	PRON
cusj-10288	107	12	become	become	VERB
cusj-10288	107	13	less	less	ADV
cusj-10288	107	14	prominent	prominent	ADJ
cusj-10288	107	15	as	as	SCONJ
cusj-10288	107	16	the	the	DET
cusj-10288	107	17	disease	disease	NOUN
cusj-10288	107	18	progresses	progress	VERB
cusj-10288	107	19	and	and	CCONJ
cusj-10288	107	20	are	be	AUX
cusj-10288	107	21	replaced	replace	VERB
cusj-10288	107	22	by	by	ADP
cusj-10288	107	23	rigidity	rigidity	NOUN
cusj-10288	107	24	and	and	CCONJ
cusj-10288	107	25	abnormal	abnormal	ADJ
cusj-10288	107	26	muscle	muscle	NOUN
cusj-10288	107	27	contractions	contraction	NOUN
cusj-10288	107	28	(	(	PUNCT
cusj-10288	107	29	dyskinesia	dyskinesia	NOUN
cusj-10288	107	30	)	)	PUNCT
cusj-10288	107	31	.	.	PUNCT
cusj-10288	108	1	patients	patient	NOUN
cusj-10288	108	2	also	also	ADV
cusj-10288	108	3	lose	lose	VERB
cusj-10288	108	4	their	their	PRON
cusj-10288	108	5	ability	ability	NOUN
cusj-10288	108	6	to	to	PART
cusj-10288	108	7	maintain	maintain	VERB
cusj-10288	108	8	a	a	DET
cusj-10288	108	9	sustained	sustained	ADJ
cusj-10288	108	10	voluntary	voluntary	ADJ
cusj-10288	108	11	muscle	muscle	NOUN
cusj-10288	108	12	contraction	contraction	NOUN
cusj-10288	108	13	and	and	CCONJ
cusj-10288	108	14	their	their	PRON
cusj-10288	108	15	fine	fine	ADJ
cusj-10288	108	16	and	and	CCONJ
cusj-10288	108	17	gross	gross	ADJ
cusj-10288	108	18	motor	motor	NOUN
cusj-10288	108	19	skills	skill	NOUN
cusj-10288	108	20	,	,	PUNCT
cusj-10288	108	21	leading	lead	VERB
cusj-10288	108	22	to	to	ADP
cusj-10288	108	23	severe	severe	ADJ
cusj-10288	108	24	disability	disability	NOUN
cusj-10288	108	25	and	and	CCONJ
cusj-10288	108	26	dependence	dependence	NOUN
cusj-10288	108	27	[	[	X
cusj-10288	108	28	46,52	46,52	X
cusj-10288	108	29	]	]	PUNCT
cusj-10288	108	30	.	.	PUNCT
cusj-10288	109	1	the	the	DET
cusj-10288	109	2	cognitive	cognitive	ADJ
cusj-10288	109	3	symptoms	symptom	NOUN
cusj-10288	109	4	include	include	VERB
cusj-10288	109	5	impairment	impairment	NOUN
cusj-10288	109	6	of	of	ADP
cusj-10288	109	7	memory	memory	NOUN
cusj-10288	109	8	,	,	PUNCT
cusj-10288	109	9	executive	executive	ADJ
cusj-10288	109	10	function	function	NOUN
cusj-10288	109	11	,	,	PUNCT
cusj-10288	109	12	language	language	NOUN
cusj-10288	109	13	,	,	PUNCT
cusj-10288	109	14	and	and	CCONJ
cusj-10288	109	15	visuospatial	visuospatial	ADJ
cusj-10288	109	16	skills	skill	NOUN
cusj-10288	109	17	,	,	PUNCT
cusj-10288	109	18	which	which	PRON
cusj-10288	109	19	worsen	worsen	VERB
cusj-10288	109	20	over	over	ADP
cusj-10288	109	21	time	time	NOUN
cusj-10288	109	22	and	and	CCONJ
cusj-10288	109	23	result	result	VERB
cusj-10288	109	24	in	in	ADP
cusj-10288	109	25	dementia	dementia	NOUN
cusj-10288	109	26	[	[	X
cusj-10288	109	27	51	51	NUM
cusj-10288	109	28	]	]	PUNCT
cusj-10288	109	29	.	.	PUNCT
cusj-10288	110	1	the	the	DET
cusj-10288	110	2	disease	disease	NOUN
cusj-10288	110	3	course	course	NOUN
cusj-10288	110	4	of	of	ADP
cusj-10288	110	5	adult	adult	NOUN
cusj-10288	110	6	-	-	PUNCT
cusj-10288	110	7	onset	onset	NOUN
cusj-10288	110	8	hd	hd	NOUN
cusj-10288	110	9	is	be	AUX
cusj-10288	110	10	typically	typically	ADV
cusj-10288	110	11	15–20	15–20	NUM
cusj-10288	110	12	years	year	NOUN
cusj-10288	110	13	from	from	ADP
cusj-10288	110	14	the	the	DET
cusj-10288	110	15	onset	onset	NOUN
cusj-10288	110	16	of	of	ADP
cusj-10288	110	17	symptoms	symptom	NOUN
cusj-10288	110	18	to	to	ADP
cusj-10288	110	19	death	death	NOUN
cusj-10288	110	20	[	[	X
cusj-10288	110	21	51	51	NUM
cusj-10288	110	22	]	]	PUNCT
cusj-10288	110	23	.	.	PUNCT
cusj-10288	111	1	the	the	DET
cusj-10288	111	2	other	other	ADJ
cusj-10288	111	3	two	two	NUM
cusj-10288	111	4	subtypes	subtype	NOUN
cusj-10288	111	5	,	,	PUNCT
cusj-10288	111	6	juvenile	juvenile	ADJ
cusj-10288	111	7	-	-	PUNCT
cusj-10288	111	8	onset	onset	ADJ
cusj-10288	111	9	and	and	CCONJ
cusj-10288	111	10	infantile	infantile	ADJ
cusj-10288	111	11	-	-	PUNCT
cusj-10288	111	12	onset	onset	NOUN
cusj-10288	111	13	hd	hd	NOUN
cusj-10288	111	14	,	,	PUNCT
cusj-10288	111	15	are	be	AUX
cusj-10288	111	16	much	much	ADV
cusj-10288	111	17	rarer	rare	ADJ
cusj-10288	111	18	and	and	CCONJ
cusj-10288	111	19	account	account	VERB
cusj-10288	111	20	for	for	ADP
cusj-10288	111	21	about	about	ADV
cusj-10288	111	22	10	10	NUM
cusj-10288	111	23	%	%	NOUN
cusj-10288	111	24	of	of	ADP
cusj-10288	111	25	hd	hd	NOUN
cusj-10288	111	26	cases	case	NOUN
cusj-10288	111	27	.	.	PUNCT
cusj-10288	112	1	they	they	PRON
cusj-10288	112	2	are	be	AUX
cusj-10288	112	3	characterized	characterize	VERB
cusj-10288	112	4	by	by	ADP
cusj-10288	112	5	an	an	DET
cusj-10288	112	6	earlier	early	ADJ
cusj-10288	112	7	onset	onset	NOUN
cusj-10288	112	8	of	of	ADP
cusj-10288	112	9	symptoms	symptom	NOUN
cusj-10288	112	10	,	,	PUNCT
cusj-10288	112	11	usually	usually	ADV
cusj-10288	112	12	before	before	ADP
cusj-10288	112	13	the	the	DET
cusj-10288	112	14	age	age	NOUN
cusj-10288	112	15	of	of	ADP
cusj-10288	112	16	20	20	NUM
cusj-10288	112	17	,	,	PUNCT
cusj-10288	112	18	and	and	CCONJ
cusj-10288	112	19	a	a	DET
cusj-10288	112	20	more	more	ADV
cusj-10288	112	21	rapid	rapid	ADJ
cusj-10288	112	22	progression	progression	NOUN
cusj-10288	112	23	of	of	ADP
cusj-10288	112	24	the	the	DET
cusj-10288	112	25	disease	disease	NOUN
cusj-10288	112	26	[	[	X
cusj-10288	112	27	46,53	46,53	NOUN
cusj-10288	112	28	]	]	PUNCT
cusj-10288	112	29	.	.	PUNCT
cusj-10288	113	1	the	the	DET
cusj-10288	113	2	main	main	ADJ
cusj-10288	113	3	features	feature	NOUN
cusj-10288	113	4	of	of	ADP
cusj-10288	113	5	these	these	DET
cusj-10288	113	6	subtypes	subtype	NOUN
cusj-10288	113	7	are	be	AUX
cusj-10288	113	8	rigidity	rigidity	NOUN
cusj-10288	113	9	,	,	PUNCT
cusj-10288	113	10	dyskinesia	dyskinesia	NOUN
cusj-10288	113	11	,	,	PUNCT
cusj-10288	113	12	and	and	CCONJ
cusj-10288	113	13	cognitive	cognitive	ADJ
cusj-10288	113	14	decline	decline	NOUN
cusj-10288	113	15	,	,	PUNCT
cusj-10288	113	16	with	with	ADP
cusj-10288	113	17	little	little	ADJ
cusj-10288	113	18	or	or	CCONJ
cusj-10288	113	19	no	no	PRON
cusj-10288	113	20	chorea	chorea	NOUN
cusj-10288	113	21	[	[	X
cusj-10288	113	22	46,53	46,53	NOUN
cusj-10288	113	23	]	]	PUNCT
cusj-10288	113	24	.	.	PUNCT
cusj-10288	114	1	these	these	DET
cusj-10288	114	2	patients	patient	NOUN
cusj-10288	114	3	often	often	ADV
cusj-10288	114	4	show	show	VERB
cusj-10288	114	5	signs	sign	NOUN
cusj-10288	114	6	of	of	ADP
cusj-10288	114	7	motor	motor	NOUN
cusj-10288	114	8	deterioration	deterioration	NOUN
cusj-10288	114	9	and	and	CCONJ
cusj-10288	114	10	poor	poor	ADJ
cusj-10288	114	11	academic	academic	ADJ
cusj-10288	114	12	performance	performance	NOUN
cusj-10288	114	13	before	before	SCONJ
cusj-10288	114	14	they	they	PRON
cusj-10288	114	15	are	be	AUX
cusj-10288	114	16	diagnosed	diagnose	VERB
cusj-10288	114	17	[	[	X
cusj-10288	114	18	46,53	46,53	NOUN
cusj-10288	114	19	]	]	PUNCT
cusj-10288	114	20	.	.	PUNCT
cusj-10288	115	1	columbia	columbia	PROPN
cusj-10288	115	2	undergraduate	undergraduate	PROPN
cusj-10288	115	3	science	science	PROPN
cusj-10288	115	4	journal	journal	PROPN
cusj-10288	115	5	vol	vol	NOUN
cusj-10288	115	6	.	.	PROPN
cusj-10288	115	7	17	17	NUM
cusj-10288	115	8	,	,	PUNCT
cusj-10288	115	9	2023	2023	NUM
cusj-10288	115	10	datta	datta	NOUN
cusj-10288	115	11	21	21	NUM
cusj-10288	115	12	genetic	genetic	ADJ
cusj-10288	115	13	modifiers	modifier	NOUN
cusj-10288	115	14	of	of	ADP
cusj-10288	115	15	huntington	huntington	PROPN
cusj-10288	115	16	’s	’s	PART
cusj-10288	115	17	disease	disease	NOUN
cusj-10288	115	18	the	the	DET
cusj-10288	115	19	discovery	discovery	NOUN
cusj-10288	115	20	of	of	ADP
cusj-10288	115	21	the	the	DET
cusj-10288	115	22	hd	hd	NOUN
cusj-10288	115	23	defect	defect	NOUN
cusj-10288	115	24	[	[	X
cusj-10288	115	25	54	54	NUM
cusj-10288	115	26	]	]	PUNCT
cusj-10288	115	27	prompted	prompt	VERB
cusj-10288	115	28	many	many	ADJ
cusj-10288	115	29	researchers	researcher	NOUN
cusj-10288	115	30	to	to	PART
cusj-10288	115	31	investigate	investigate	VERB
cusj-10288	115	32	the	the	DET
cusj-10288	115	33	role	role	NOUN
cusj-10288	115	34	of	of	ADP
cusj-10288	115	35	hd	hd	NOUN
cusj-10288	115	36	genes	gene	NOUN
cusj-10288	115	37	that	that	PRON
cusj-10288	115	38	were	be	AUX
cusj-10288	115	39	chosen	choose	VERB
cusj-10288	115	40	based	base	VERB
cusj-10288	115	41	on	on	ADP
cusj-10288	115	42	their	their	PRON
cusj-10288	115	43	functional	functional	ADJ
cusj-10288	115	44	relevance	relevance	NOUN
cusj-10288	115	45	.	.	PUNCT
cusj-10288	116	1	however	however	ADV
cusj-10288	116	2	,	,	PUNCT
cusj-10288	116	3	a	a	DET
cusj-10288	116	4	new	new	ADJ
cusj-10288	116	5	approach	approach	NOUN
cusj-10288	116	6	emerged	emerge	VERB
cusj-10288	116	7	in	in	ADP
cusj-10288	116	8	the	the	DET
cusj-10288	116	9	early	early	ADJ
cusj-10288	116	10	21st	21st	ADJ
cusj-10288	116	11	century	century	NOUN
cusj-10288	116	12	,	,	PUNCT
cusj-10288	116	13	which	which	PRON
cusj-10288	116	14	was	be	AUX
cusj-10288	116	15	based	base	VERB
cusj-10288	116	16	on	on	ADP
cusj-10288	116	17	two	two	NUM
cusj-10288	116	18	major	major	ADJ
cusj-10288	116	19	advances	advance	NOUN
cusj-10288	116	20	in	in	ADP
cusj-10288	116	21	human	human	ADJ
cusj-10288	116	22	genetics	genetic	NOUN
cusj-10288	116	23	:	:	PUNCT
cusj-10288	116	24	firstly	firstly	ADV
cusj-10288	116	25	,	,	PUNCT
cusj-10288	116	26	the	the	DET
cusj-10288	116	27	identification	identification	NOUN
cusj-10288	116	28	of	of	ADP
cusj-10288	116	29	common	common	ADJ
cusj-10288	116	30	genetic	genetic	ADJ
cusj-10288	116	31	variations	variation	NOUN
cusj-10288	116	32	across	across	ADP
cusj-10288	116	33	the	the	DET
cusj-10288	116	34	genome	genome	NOUN
cusj-10288	116	35	,	,	PUNCT
cusj-10288	116	36	known	know	VERB
cusj-10288	116	37	as	as	ADP
cusj-10288	116	38	single	single	ADJ
cusj-10288	116	39	nucleotide	nucleotide	ADJ
cusj-10288	116	40	polymorphisms	polymorphism	NOUN
cusj-10288	116	41	(	(	PUNCT
cusj-10288	116	42	snps	snps	PROPN
cusj-10288	116	43	)	)	PUNCT
cusj-10288	116	44	,	,	PUNCT
cusj-10288	116	45	and	and	CCONJ
cusj-10288	116	46	secondly	secondly	ADV
cusj-10288	116	47	,	,	PUNCT
cusj-10288	116	48	the	the	DET
cusj-10288	116	49	development	development	NOUN
cusj-10288	116	50	of	of	ADP
cusj-10288	116	51	oligonucleotide	oligonucleotide	ADJ
cusj-10288	116	52	array	array	PROPN
cusj-10288	116	53	technology	technology	NOUN
cusj-10288	116	54	,	,	PUNCT
cusj-10288	116	55	which	which	PRON
cusj-10288	116	56	enabled	enable	VERB
cusj-10288	116	57	the	the	DET
cusj-10288	116	58	simultaneous	simultaneous	ADJ
cusj-10288	116	59	genotyping	genotyping	NOUN
cusj-10288	116	60	of	of	ADP
cusj-10288	116	61	hundreds	hundred	NOUN
cusj-10288	116	62	of	of	ADP
cusj-10288	116	63	thousands	thousand	NOUN
cusj-10288	116	64	to	to	PART
cusj-10288	116	65	millions	million	NOUN
cusj-10288	116	66	of	of	ADP
cusj-10288	116	67	snps	snps	PROPN
cusj-10288	116	68	for	for	ADP
cusj-10288	116	69	unbiased	unbiased	ADJ
cusj-10288	116	70	genetic	genetic	ADJ
cusj-10288	116	71	studies	study	NOUN
cusj-10288	116	72	[	[	X
cusj-10288	116	73	55	55	NUM
cusj-10288	116	74	]	]	PUNCT
cusj-10288	116	75	.	.	PUNCT
cusj-10288	117	1	this	this	DET
cusj-10288	117	2	approach	approach	NOUN
cusj-10288	117	3	,	,	PUNCT
cusj-10288	117	4	called	call	VERB
cusj-10288	117	5	genome	genome	NOUN
cusj-10288	117	6	-	-	PUNCT
cusj-10288	117	7	wide	wide	ADJ
cusj-10288	117	8	association	association	NOUN
cusj-10288	117	9	analysis	analysis	NOUN
cusj-10288	117	10	(	(	PUNCT
cusj-10288	117	11	gwa	gwa	NOUN
cusj-10288	117	12	)	)	PUNCT
cusj-10288	117	13	,	,	PUNCT
cusj-10288	117	14	allowed	allow	VERB
cusj-10288	117	15	the	the	DET
cusj-10288	117	16	researchers	researcher	NOUN
cusj-10288	117	17	to	to	PART
cusj-10288	117	18	scan	scan	VERB
cusj-10288	117	19	the	the	DET
cusj-10288	117	20	entire	entire	ADJ
cusj-10288	117	21	genome	genome	NOUN
cusj-10288	117	22	for	for	ADP
cusj-10288	117	23	genetic	genetic	ADJ
cusj-10288	117	24	factors	factor	NOUN
cusj-10288	117	25	that	that	PRON
cusj-10288	117	26	influence	influence	VERB
cusj-10288	117	27	the	the	DET
cusj-10288	117	28	hd	hd	NOUN
cusj-10288	117	29	phenotype	phenotype	NOUN
cusj-10288	117	30	,	,	PUNCT
cusj-10288	117	31	without	without	ADP
cusj-10288	117	32	relying	rely	VERB
cusj-10288	117	33	on	on	ADP
cusj-10288	117	34	prior	prior	ADJ
cusj-10288	117	35	knowledge	knowledge	NOUN
cusj-10288	117	36	of	of	ADP
cusj-10288	117	37	gene	gene	NOUN
cusj-10288	117	38	function	function	NOUN
cusj-10288	117	39	.	.	PUNCT
cusj-10288	118	1	to	to	PART
cusj-10288	118	2	apply	apply	VERB
cusj-10288	118	3	this	this	DET
cusj-10288	118	4	approach	approach	NOUN
cusj-10288	118	5	to	to	ADP
cusj-10288	118	6	hd	hd	VERB
cusj-10288	118	7	with	with	ADP
cusj-10288	118	8	sufficient	sufficient	ADJ
cusj-10288	118	9	statistical	statistical	ADJ
cusj-10288	118	10	power	power	NOUN
cusj-10288	118	11	,	,	PUNCT
cusj-10288	118	12	three	three	NUM
cusj-10288	118	13	additional	additional	ADJ
cusj-10288	118	14	requirements	requirement	NOUN
cusj-10288	118	15	had	have	VERB
cusj-10288	118	16	to	to	PART
cusj-10288	118	17	be	be	AUX
cusj-10288	118	18	met	meet	VERB
cusj-10288	118	19	:	:	PUNCT
cusj-10288	118	20	firstly	firstly	ADV
cusj-10288	118	21	,	,	PUNCT
cusj-10288	118	22	the	the	DET
cusj-10288	118	23	availability	availability	NOUN
cusj-10288	118	24	of	of	ADP
cusj-10288	118	25	genomic	genomic	ADJ
cusj-10288	118	26	dna	dna	PROPN
cusj-10288	118	27	from	from	ADP
cusj-10288	118	28	a	a	DET
cusj-10288	118	29	large	large	ADJ
cusj-10288	118	30	number	number	NOUN
cusj-10288	118	31	of	of	ADP
cusj-10288	118	32	hd	hd	NOUN
cusj-10288	118	33	subjects	subject	NOUN
cusj-10288	118	34	for	for	ADP
cusj-10288	118	35	genotyping	genotyping	NOUN
cusj-10288	118	36	;	;	PUNCT
cusj-10288	118	37	secondly	secondly	ADV
cusj-10288	118	38	,	,	PUNCT
cusj-10288	118	39	the	the	DET
cusj-10288	118	40	definition	definition	NOUN
cusj-10288	118	41	of	of	ADP
cusj-10288	118	42	a	a	DET
cusj-10288	118	43	robust	robust	ADJ
cusj-10288	118	44	phenotype	phenotype	NOUN
cusj-10288	118	45	that	that	PRON
cusj-10288	118	46	accounted	account	VERB
cusj-10288	118	47	for	for	ADP
cusj-10288	118	48	the	the	DET
cusj-10288	118	49	effects	effect	NOUN
cusj-10288	118	50	of	of	ADP
cusj-10288	118	51	the	the	DET
cusj-10288	118	52	cag	cag	PROPN
cusj-10288	118	53	repeat	repeat	PROPN
cusj-10288	118	54	size	size	NOUN
cusj-10288	118	55	,	,	PUNCT
cusj-10288	118	56	which	which	PRON
cusj-10288	118	57	is	be	AUX
cusj-10288	118	58	the	the	DET
cusj-10288	118	59	main	main	ADJ
cusj-10288	118	60	determinant	determinant	NOUN
cusj-10288	118	61	of	of	ADP
cusj-10288	118	62	the	the	DET
cusj-10288	118	63	hd	hd	NOUN
cusj-10288	118	64	phenotype	phenotype	NOUN
cusj-10288	118	65	;	;	PUNCT
cusj-10288	118	66	and	and	CCONJ
cusj-10288	118	67	thirdly	thirdly	ADV
cusj-10288	118	68	,	,	PUNCT
cusj-10288	118	69	the	the	DET
cusj-10288	118	70	exclusion	exclusion	NOUN
cusj-10288	118	71	of	of	ADP
cusj-10288	118	72	any	any	DET
cusj-10288	118	73	potential	potential	ADJ
cusj-10288	118	74	modifier	modifier	NOUN
cusj-10288	118	75	factors	factor	NOUN
cusj-10288	118	76	that	that	PRON
cusj-10288	118	77	are	be	AUX
cusj-10288	118	78	linked	link	VERB
cusj-10288	118	79	to	to	ADP
cusj-10288	118	80	htt	htt	NOUN
cusj-10288	118	81	and	and	CCONJ
cusj-10288	118	82	act	act	VERB
cusj-10288	118	83	in	in	ADP
cusj-10288	118	84	cis	cis	NOUN
cusj-10288	118	85	to	to	PART
cusj-10288	118	86	modify	modify	VERB
cusj-10288	118	87	the	the	DET
cusj-10288	118	88	effect	effect	NOUN
cusj-10288	118	89	of	of	ADP
cusj-10288	118	90	the	the	DET
cusj-10288	118	91	mutation	mutation	NOUN
cusj-10288	118	92	,	,	PUNCT
cusj-10288	118	93	as	as	SCONJ
cusj-10288	118	94	these	these	DET
cusj-10288	118	95	factors	factor	NOUN
cusj-10288	118	96	would	would	AUX
cusj-10288	118	97	confound	confound	VERB
cusj-10288	118	98	the	the	DET
cusj-10288	118	99	genome	genome	NOUN
cusj-10288	118	100	-	-	PUNCT
cusj-10288	118	101	wide	wide	ADJ
cusj-10288	118	102	search	search	NOUN
cusj-10288	118	103	[	[	X
cusj-10288	118	104	55	55	NUM
cusj-10288	118	105	]	]	PUNCT
cusj-10288	118	106	.	.	PUNCT
cusj-10288	119	1	statistically	statistically	ADV
cusj-10288	119	2	assessing	assess	VERB
cusj-10288	119	3	the	the	DET
cusj-10288	119	4	relationship	relationship	NOUN
cusj-10288	119	5	between	between	ADP
cusj-10288	119	6	the	the	DET
cusj-10288	119	7	length	length	NOUN
cusj-10288	119	8	of	of	ADP
cusj-10288	119	9	inherited	inherit	VERB
cusj-10288	119	10	cag	cag	PROPN
cusj-10288	119	11	repeats	repeat	NOUN
cusj-10288	119	12	and	and	CCONJ
cusj-10288	119	13	the	the	DET
cusj-10288	119	14	age	age	NOUN
cusj-10288	119	15	of	of	ADP
cusj-10288	119	16	motor	motor	NOUN
cusj-10288	119	17	onset	onset	NOUN
cusj-10288	119	18	provided	provide	VERB
cusj-10288	119	19	a	a	DET
cusj-10288	119	20	vigorous	vigorous	ADJ
cusj-10288	119	21	hd	hd	NOUN
cusj-10288	119	22	phenotype	phenotype	NOUN
cusj-10288	119	23	that	that	PRON
cusj-10288	119	24	accounted	account	VERB
cusj-10288	119	25	for	for	ADP
cusj-10288	119	26	the	the	DET
cusj-10288	119	27	effect	effect	NOUN
cusj-10288	119	28	of	of	ADP
cusj-10288	119	29	cag	cag	PROPN
cusj-10288	119	30	repeats	repeat	NOUN
cusj-10288	119	31	.	.	PUNCT
cusj-10288	120	1	due	due	ADP
cusj-10288	120	2	to	to	ADP
cusj-10288	120	3	the	the	DET
cusj-10288	120	4	danger	danger	NOUN
cusj-10288	120	5	of	of	ADP
cusj-10288	120	6	including	include	VERB
cusj-10288	120	7	inexplicably	inexplicably	ADV
cusj-10288	120	8	influential	influential	ADJ
cusj-10288	120	9	outliers	outlier	NOUN
cusj-10288	120	10	,	,	PUNCT
cusj-10288	120	11	the	the	DET
cusj-10288	120	12	analysis	analysis	NOUN
cusj-10288	120	13	was	be	AUX
cusj-10288	120	14	limited	limit	VERB
cusj-10288	120	15	to	to	ADP
cusj-10288	120	16	cag	cag	PROPN
cusj-10288	120	17	repeat	repeat	NOUN
cusj-10288	120	18	lengths	length	NOUN
cusj-10288	120	19	typical	typical	ADJ
cusj-10288	120	20	of	of	ADP
cusj-10288	120	21	adult	adult	NOUN
cusj-10288	120	22	-	-	PUNCT
cusj-10288	120	23	onset	onset	NOUN
cusj-10288	120	24	(	(	PUNCT
cusj-10288	120	25	40	40	NUM
cusj-10288	120	26	to	to	ADP
cusj-10288	120	27	53–55	53–55	NUM
cusj-10288	120	28	)	)	PUNCT
cusj-10288	120	29	and	and	CCONJ
cusj-10288	120	30	sufficient	sufficient	ADJ
cusj-10288	120	31	representation	representation	NOUN
cusj-10288	120	32	of	of	ADP
cusj-10288	120	33	subjects	subject	NOUN
cusj-10288	120	34	to	to	PART
cusj-10288	120	35	guarantee	guarantee	VERB
cusj-10288	120	36	consistent	consistent	ADJ
cusj-10288	120	37	results	result	NOUN
cusj-10288	120	38	[	[	X
cusj-10288	120	39	56	56	NUM
cusj-10288	120	40	]	]	PUNCT
cusj-10288	120	41	.	.	PUNCT
cusj-10288	121	1	based	base	VERB
cusj-10288	121	2	on	on	ADP
cusj-10288	121	3	their	their	PRON
cusj-10288	121	4	inherited	inherit	VERB
cusj-10288	121	5	cag	cag	PROPN
cusj-10288	121	6	repeat	repeat	NOUN
cusj-10288	121	7	lengths	length	NOUN
cusj-10288	121	8	,	,	PUNCT
cusj-10288	121	9	>	>	PUNCT
cusj-10288	121	10	90	90	NUM
cusj-10288	121	11	%	%	NOUN
cusj-10288	121	12	of	of	ADP
cusj-10288	121	13	hd	hd	NOUN
cusj-10288	121	14	subjects	subject	NOUN
cusj-10288	121	15	met	meet	VERB
cusj-10288	121	16	these	these	DET
cusj-10288	121	17	criteria	criterion	NOUN
cusj-10288	121	18	,	,	PUNCT
cusj-10288	121	19	allowing	allow	VERB
cusj-10288	121	20	a	a	DET
cusj-10288	121	21	standard	standard	ADJ
cusj-10288	121	22	curve	curve	NOUN
cusj-10288	121	23	to	to	PART
cusj-10288	121	24	be	be	AUX
cusj-10288	121	25	produced	produce	VERB
cusj-10288	121	26	that	that	PRON
cusj-10288	121	27	relates	relate	VERB
cusj-10288	121	28	cag	cag	PROPN
cusj-10288	121	29	repeat	repeat	VERB
cusj-10288	121	30	size	size	NOUN
cusj-10288	121	31	to	to	PART
cusj-10288	121	32	average	average	VERB
cusj-10288	121	33	age	age	NOUN
cusj-10288	121	34	-	-	PUNCT
cusj-10288	121	35	at	at	ADP
cusj-10288	121	36	-	-	PUNCT
cusj-10288	121	37	onset	onset	NOUN
cusj-10288	121	38	.	.	PUNCT
cusj-10288	122	1	in	in	ADP
cusj-10288	122	2	the	the	DET
cusj-10288	122	3	absence	absence	NOUN
cusj-10288	122	4	of	of	ADP
cusj-10288	122	5	the	the	DET
cusj-10288	122	6	effects	effect	NOUN
cusj-10288	122	7	of	of	ADP
cusj-10288	122	8	the	the	DET
cusj-10288	122	9	cag	cag	PROPN
cusj-10288	122	10	repeat	repeat	PROPN
cusj-10288	122	11	size	size	NOUN
cusj-10288	122	12	,	,	PUNCT
cusj-10288	122	13	an	an	DET
cusj-10288	122	14	evaluation	evaluation	NOUN
cusj-10288	122	15	of	of	ADP
cusj-10288	122	16	this	this	DET
cusj-10288	122	17	expected	expect	VERB
cusj-10288	122	18	age	age	NOUN
cusj-10288	122	19	-	-	PUNCT
cusj-10288	122	20	at	at	ADP
cusj-10288	122	21	-	-	PUNCT
cusj-10288	122	22	onset	onset	NOUN
cusj-10288	122	23	with	with	ADP
cusj-10288	122	24	the	the	DET
cusj-10288	122	25	individual	individual	NOUN
cusj-10288	122	26	's	's	PART
cusj-10288	122	27	observed	observe	VERB
cusj-10288	122	28	age	age	NOUN
cusj-10288	122	29	-	-	PUNCT
cusj-10288	122	30	at	at	ADP
cusj-10288	122	31	-	-	PUNCT
cusj-10288	122	32	onset	onset	NOUN
cusj-10288	122	33	provided	provide	VERB
cusj-10288	122	34	the	the	DET
cusj-10288	122	35	phenotype	phenotype	NOUN
cusj-10288	122	36	for	for	ADP
cusj-10288	122	37	analysis	analysis	NOUN
cusj-10288	122	38	of	of	ADP
cusj-10288	122	39	genetic	genetic	ADJ
cusj-10288	122	40	effects	effect	NOUN
cusj-10288	122	41	on	on	ADP
cusj-10288	122	42	onset	onset	NOUN
cusj-10288	122	43	[	[	X
cusj-10288	122	44	57	57	NUM
cusj-10288	122	45	]	]	PUNCT
cusj-10288	122	46	.	.	PUNCT
cusj-10288	123	1	it	it	PRON
cusj-10288	123	2	was	be	AUX
cusj-10288	123	3	fundamentally	fundamentally	ADV
cusj-10288	123	4	a	a	DET
cusj-10288	123	5	matter	matter	NOUN
cusj-10288	123	6	of	of	ADP
cusj-10288	123	7	subtracting	subtract	VERB
cusj-10288	123	8	the	the	DET
cusj-10288	123	9	expected	expect	VERB
cusj-10288	123	10	age	age	NOUN
cusj-10288	123	11	-	-	PUNCT
cusj-10288	123	12	at	at	ADP
cusj-10288	123	13	-	-	PUNCT
cusj-10288	123	14	onset	onset	NOUN
cusj-10288	123	15	from	from	ADP
cusj-10288	123	16	the	the	DET
cusj-10288	123	17	observed	observe	VERB
cusj-10288	123	18	age	age	NOUN
cusj-10288	123	19	-	-	PUNCT
cusj-10288	123	20	at	at	ADP
cusj-10288	123	21	-	-	PUNCT
cusj-10288	123	22	onset	onset	NOUN
cusj-10288	123	23	to	to	PART
cusj-10288	123	24	obtain	obtain	VERB
cusj-10288	123	25	the	the	DET
cusj-10288	123	26	test	test	NOUN
cusj-10288	123	27	phenotype	phenotype	NOUN
cusj-10288	123	28	,	,	PUNCT
cusj-10288	123	29	or	or	CCONJ
cusj-10288	123	30	residual	residual	ADJ
cusj-10288	123	31	ageat	ageat	NOUN
cusj-10288	123	32	-	-	PUNCT
cusj-10288	123	33	onset	onset	NOUN
cusj-10288	123	34	,	,	PUNCT
cusj-10288	123	35	which	which	PRON
cusj-10288	123	36	was	be	AUX
cusj-10288	123	37	either	either	CCONJ
cusj-10288	123	38	a	a	DET
cusj-10288	123	39	positive	positive	ADJ
cusj-10288	123	40	or	or	CCONJ
cusj-10288	123	41	negative	negative	ADJ
cusj-10288	123	42	number	number	NOUN
cusj-10288	123	43	of	of	ADP
cusj-10288	123	44	years	year	NOUN
cusj-10288	123	45	based	base	VERB
cusj-10288	123	46	on	on	ADP
cusj-10288	123	47	whether	whether	SCONJ
cusj-10288	123	48	the	the	DET
cusj-10288	123	49	subject	subject	NOUN
cusj-10288	123	50	's	's	PART
cusj-10288	123	51	onset	onset	NOUN
cusj-10288	123	52	was	be	AUX
cusj-10288	123	53	later	later	ADV
cusj-10288	123	54	or	or	CCONJ
cusj-10288	123	55	earlier	early	ADV
cusj-10288	123	56	than	than	SCONJ
cusj-10288	123	57	anticipated	anticipate	VERB
cusj-10288	123	58	.	.	PUNCT
cusj-10288	124	1	it	it	PRON
cusj-10288	124	2	was	be	AUX
cusj-10288	124	3	possible	possible	ADJ
cusj-10288	124	4	to	to	PART
cusj-10288	124	5	test	test	VERB
cusj-10288	124	6	whether	whether	SCONJ
cusj-10288	124	7	genetic	genetic	ADJ
cusj-10288	124	8	variations	variation	NOUN
cusj-10288	124	9	at	at	ADP
cusj-10288	124	10	the	the	DET
cusj-10288	124	11	htt	htt	NOUN
cusj-10288	124	12	locus	locus	NOUN
cusj-10288	124	13	other	other	ADJ
cusj-10288	124	14	than	than	ADP
cusj-10288	124	15	the	the	DET
cusj-10288	124	16	cag	cag	PROPN
cusj-10288	124	17	repeat	repeat	PROPN
cusj-10288	124	18	size	size	NOUN
cusj-10288	124	19	affect	affect	VERB
cusj-10288	124	20	age	age	NOUN
cusj-10288	124	21	-	-	PUNCT
cusj-10288	124	22	at	at	ADP
cusj-10288	124	23	-	-	PUNCT
cusj-10288	124	24	onset	onset	NOUN
cusj-10288	124	25	by	by	ADP
cusj-10288	124	26	using	use	VERB
cusj-10288	124	27	residual	residual	ADJ
cusj-10288	124	28	age	age	NOUN
cusj-10288	124	29	-	-	PUNCT
cusj-10288	124	30	at	at	ADP
cusj-10288	124	31	-	-	PUNCT
cusj-10288	124	32	onset	onset	NOUN
cusj-10288	124	33	as	as	ADP
cusj-10288	124	34	a	a	DET
cusj-10288	124	35	relevant	relevant	ADJ
cusj-10288	124	36	hd	hd	NOUN
cusj-10288	124	37	phenotype	phenotype	NOUN
cusj-10288	124	38	and	and	CCONJ
cusj-10288	124	39	several	several	ADJ
cusj-10288	124	40	thousand	thousand	NUM
cusj-10288	124	41	unrelated	unrelated	ADJ
cusj-10288	124	42	hd	hd	NOUN
cusj-10288	124	43	subjects	subject	NOUN
cusj-10288	124	44	[	[	X
cusj-10288	124	45	55	55	NUM
cusj-10288	124	46	]	]	PUNCT
cusj-10288	124	47	.	.	PUNCT
cusj-10288	125	1	in	in	ADP
cusj-10288	125	2	order	order	NOUN
cusj-10288	125	3	to	to	PART
cusj-10288	125	4	examine	examine	VERB
cusj-10288	125	5	this	this	PRON
cusj-10288	125	6	,	,	PUNCT
cusj-10288	125	7	common	common	ADJ
cusj-10288	125	8	single	single	ADJ
cusj-10288	125	9	nucleotide	nucleotide	NOUN
cusj-10288	125	10	polymorphisms	polymorphism	NOUN
cusj-10288	125	11	(	(	PUNCT
cusj-10288	125	12	snps	snps	PROPN
cusj-10288	125	13	)	)	PUNCT
cusj-10288	125	14	were	be	AUX
cusj-10288	125	15	compiled	compile	VERB
cusj-10288	125	16	across	across	ADP
cusj-10288	125	17	the	the	DET
cusj-10288	125	18	gene	gene	NOUN
cusj-10288	125	19	and	and	CCONJ
cusj-10288	125	20	defined	define	VERB
cusj-10288	125	21	as	as	ADP
cusj-10288	125	22	haplotypes	haplotype	NOUN
cusj-10288	125	23	(	(	PUNCT
cusj-10288	125	24	i.e.	i.e.	X
cusj-10288	125	25	the	the	DET
cusj-10288	125	26	linear	linear	ADJ
cusj-10288	125	27	array	array	NOUN
cusj-10288	125	28	of	of	ADP
cusj-10288	125	29	alleles	allele	NOUN
cusj-10288	125	30	at	at	ADP
cusj-10288	125	31	multiple	multiple	ADJ
cusj-10288	125	32	snps	snps	PROPN
cusj-10288	125	33	along	along	ADP
cusj-10288	125	34	the	the	DET
cusj-10288	125	35	chromosome	chromosome	NOUN
cusj-10288	125	36	,	,	PUNCT
cusj-10288	125	37	conducted	conduct	VERB
cusj-10288	125	38	as	as	ADP
cusj-10288	125	39	a	a	DET
cusj-10288	125	40	physically	physically	ADV
cusj-10288	125	41	linked	link	VERB
cusj-10288	125	42	set	set	VERB
cusj-10288	125	43	to	to	PART
cusj-10288	125	44	progeny	progeny	VERB
cusj-10288	125	45	—	—	PUNCT
cusj-10288	125	46	basically	basically	ADV
cusj-10288	125	47	a	a	DET
cusj-10288	125	48	digital	digital	ADJ
cusj-10288	125	49	fingerprint	fingerprint	NOUN
cusj-10288	125	50	for	for	ADP
cusj-10288	125	51	the	the	DET
cusj-10288	125	52	htt	htt	NOUN
cusj-10288	125	53	region	region	NOUN
cusj-10288	125	54	)	)	PUNCT
cusj-10288	126	1	[	[	X
cusj-10288	126	2	55	55	NUM
cusj-10288	126	3	]	]	PUNCT
cusj-10288	126	4	.	.	PUNCT
cusj-10288	127	1	in	in	ADP
cusj-10288	127	2	addition	addition	NOUN
cusj-10288	127	3	,	,	PUNCT
cusj-10288	127	4	expanded	expand	VERB
cusj-10288	127	5	cag	cag	PROPN
cusj-10288	127	6	alleles	allele	NOUN
cusj-10288	127	7	associated	associate	VERB
cusj-10288	127	8	with	with	ADP
cusj-10288	127	9	hd	hd	PROPN
cusj-10288	127	10	were	be	AUX
cusj-10288	127	11	found	find	VERB
cusj-10288	127	12	in	in	ADP
cusj-10288	127	13	multiple	multiple	ADJ
cusj-10288	127	14	haplotypes	haplotype	NOUN
cusj-10288	127	15	,	,	PUNCT
cusj-10288	127	16	indicating	indicate	VERB
cusj-10288	127	17	that	that	SCONJ
cusj-10288	127	18	multiple	multiple	ADJ
cusj-10288	127	19	independent	independent	ADJ
cusj-10288	127	20	ancestral	ancestral	ADJ
cusj-10288	127	21	hd	hd	PROPN
cusj-10288	127	22	cag	cag	PROPN
cusj-10288	127	23	expansion	expansion	NOUN
cusj-10288	127	24	mutations	mutation	NOUN
cusj-10288	127	25	contributed	contribute	VERB
cusj-10288	127	26	to	to	ADP
cusj-10288	127	27	the	the	DET
cusj-10288	127	28	contemporary	contemporary	ADJ
cusj-10288	127	29	population	population	NOUN
cusj-10288	127	30	of	of	ADP
cusj-10288	127	31	hd	hd	NOUN
cusj-10288	127	32	individuals	individual	NOUN
cusj-10288	127	33	[	[	X
cusj-10288	127	34	58	58	NUM
cusj-10288	127	35	]	]	PUNCT
cusj-10288	127	36	.	.	PUNCT
cusj-10288	128	1	the	the	DET
cusj-10288	128	2	most	most	ADV
cusj-10288	128	3	common	common	ADJ
cusj-10288	128	4	haplotypes	haplotype	NOUN
cusj-10288	128	5	,	,	PUNCT
cusj-10288	128	6	representing	represent	VERB
cusj-10288	128	7	more	more	ADJ
cusj-10288	128	8	than	than	ADP
cusj-10288	128	9	83	83	NUM
cusj-10288	128	10	%	%	NOUN
cusj-10288	128	11	of	of	ADP
cusj-10288	128	12	hd	hd	NOUN
cusj-10288	128	13	subjects	subject	NOUN
cusj-10288	128	14	,	,	PUNCT
cusj-10288	128	15	were	be	AUX
cusj-10288	128	16	not	not	PART
cusj-10288	128	17	related	relate	VERB
cusj-10288	128	18	with	with	ADP
cusj-10288	128	19	differences	difference	NOUN
cusj-10288	128	20	in	in	ADP
cusj-10288	128	21	onset	onset	NOUN
cusj-10288	128	22	age	age	NOUN
cusj-10288	128	23	,	,	PUNCT
cusj-10288	128	24	which	which	PRON
cusj-10288	128	25	suggests	suggest	VERB
cusj-10288	128	26	that	that	SCONJ
cusj-10288	128	27	genetic	genetic	ADJ
cusj-10288	128	28	factors	factor	NOUN
cusj-10288	128	29	usually	usually	ADV
cusj-10288	128	30	act	act	VERB
cusj-10288	128	31	in	in	ADP
cusj-10288	128	32	transfer	transfer	NOUN
cusj-10288	128	33	through	through	ADP
cusj-10288	128	34	genes	gene	NOUN
cusj-10288	128	35	detached	detach	VERB
cusj-10288	128	36	from	from	ADP
cusj-10288	128	37	htt	htt	NOUN
cusj-10288	128	38	[	[	X
cusj-10288	128	39	58	58	NUM
cusj-10288	128	40	]	]	PUNCT
cusj-10288	128	41	.	.	PUNCT
cusj-10288	129	1	accordingly	accordingly	ADV
cusj-10288	129	2	,	,	PUNCT
cusj-10288	129	3	hd	hd	PROPN
cusj-10288	129	4	is	be	AUX
cusj-10288	129	5	viewed	view	VERB
cusj-10288	129	6	as	as	ADP
cusj-10288	129	7	a	a	DET
cusj-10288	129	8	prototypical	prototypical	ADJ
cusj-10288	129	9	autosomal	autosomal	ADJ
cusj-10288	129	10	dominant	dominant	ADJ
cusj-10288	129	11	genetic	genetic	ADJ
cusj-10288	129	12	disorder	disorder	NOUN
cusj-10288	129	13	based	base	VERB
cusj-10288	129	14	on	on	ADP
cusj-10288	129	15	whether	whether	SCONJ
cusj-10288	129	16	it	it	PRON
cusj-10288	129	17	is	be	AUX
cusj-10288	129	18	passed	pass	VERB
cusj-10288	129	19	on	on	ADP
cusj-10288	129	20	to	to	PART
cusj-10288	129	21	progeny	progeny	VERB
cusj-10288	129	22	(	(	PUNCT
cusj-10288	129	23	or	or	CCONJ
cusj-10288	129	24	not	not	PART
cusj-10288	129	25	)	)	PUNCT
cusj-10288	129	26	,	,	PUNCT
cusj-10288	129	27	but	but	CCONJ
cusj-10288	129	28	the	the	DET
cusj-10288	129	29	timing	timing	NOUN
cusj-10288	129	30	of	of	ADP
cusj-10288	129	31	disease	disease	NOUN
cusj-10288	129	32	onset	onset	NOUN
cusj-10288	129	33	is	be	AUX
cusj-10288	129	34	actually	actually	ADV
cusj-10288	129	35	polygenic	polygenic	ADJ
cusj-10288	129	36	,	,	PUNCT
cusj-10288	129	37	determined	determine	VERB
cusj-10288	129	38	by	by	ADP
cusj-10288	129	39	the	the	DET
cusj-10288	129	40	combination	combination	NOUN
cusj-10288	129	41	of	of	ADP
cusj-10288	129	42	cag	cag	PROPN
cusj-10288	129	43	repeats	repeat	NOUN
cusj-10288	129	44	and	and	CCONJ
cusj-10288	129	45	other	other	ADJ
cusj-10288	129	46	genetic	genetic	ADJ
cusj-10288	129	47	factors	factor	NOUN
cusj-10288	129	48	.	.	PUNCT
cusj-10288	130	1	columbia	columbia	PROPN
cusj-10288	130	2	undergraduate	undergraduate	PROPN
cusj-10288	130	3	science	science	PROPN
cusj-10288	130	4	journal	journal	PROPN
cusj-10288	130	5	vol	vol	NOUN
cusj-10288	130	6	.	.	PROPN
cusj-10288	130	7	17	17	NUM
cusj-10288	130	8	,	,	PUNCT
cusj-10288	130	9	2023	2023	NUM
cusj-10288	130	10	datta	datta	NOUN
cusj-10288	130	11	22	22	NUM
cusj-10288	130	12	factors	factor	NOUN
cusj-10288	130	13	that	that	PRON
cusj-10288	130	14	play	play	VERB
cusj-10288	130	15	a	a	DET
cusj-10288	130	16	role	role	NOUN
cusj-10288	130	17	in	in	ADP
cusj-10288	130	18	the	the	DET
cusj-10288	130	19	development	development	NOUN
cusj-10288	130	20	of	of	ADP
cusj-10288	130	21	hd	hd	PROPN
cusj-10288	130	22	1	1	NUM
cusj-10288	130	23	.	.	PUNCT
cusj-10288	130	24	mitochondrial	mitochondrial	ADJ
cusj-10288	130	25	disorder	disorder	NOUN
cusj-10288	130	26	in	in	ADP
cusj-10288	130	27	early	early	ADJ
cusj-10288	130	28	studies	study	NOUN
cusj-10288	130	29	,	,	PUNCT
cusj-10288	130	30	functional	functional	ADJ
cusj-10288	130	31	abnormalities	abnormality	NOUN
cusj-10288	130	32	in	in	ADP
cusj-10288	130	33	mitochondria	mitochondria	NOUN
cusj-10288	130	34	were	be	AUX
cusj-10288	130	35	discovered	discover	VERB
cusj-10288	130	36	,	,	PUNCT
cusj-10288	130	37	indicating	indicate	VERB
cusj-10288	130	38	that	that	SCONJ
cusj-10288	130	39	mitochondrial	mitochondrial	ADJ
cusj-10288	130	40	dysfunction	dysfunction	NOUN
cusj-10288	130	41	plays	play	VERB
cusj-10288	130	42	an	an	DET
cusj-10288	130	43	essential	essential	ADJ
cusj-10288	130	44	role	role	NOUN
cusj-10288	130	45	in	in	ADP
cusj-10288	130	46	the	the	DET
cusj-10288	130	47	pathogenesis	pathogenesis	NOUN
cusj-10288	130	48	of	of	ADP
cusj-10288	130	49	hd	hd	NOUN
cusj-10288	130	50	and	and	CCONJ
cusj-10288	130	51	this	this	PRON
cusj-10288	130	52	is	be	AUX
cusj-10288	130	53	usually	usually	ADV
cusj-10288	130	54	seen	see	VERB
cusj-10288	130	55	in	in	ADP
cusj-10288	130	56	the	the	DET
cusj-10288	130	57	early	early	ADJ
cusj-10288	130	58	disease	disease	NOUN
cusj-10288	130	59	process	process	NOUN
cusj-10288	130	60	.	.	PUNCT
cusj-10288	131	1	the	the	DET
cusj-10288	131	2	caudate	caudate	NOUN
cusj-10288	131	3	and	and	CCONJ
cusj-10288	131	4	to	to	ADP
cusj-10288	131	5	a	a	DET
cusj-10288	131	6	lesser	less	ADJ
cusj-10288	131	7	extent	extent	NOUN
cusj-10288	131	8	the	the	DET
cusj-10288	131	9	cortex	cortex	NOUN
cusj-10288	131	10	of	of	ADP
cusj-10288	131	11	post	post	ADJ
cusj-10288	131	12	-	-	ADJ
cusj-10288	131	13	mortem	mortem	ADJ
cusj-10288	131	14	hd	hd	NOUN
cusj-10288	131	15	brains	brain	NOUN
cusj-10288	131	16	have	have	VERB
cusj-10288	131	17	succinate	succinate	NOUN
cusj-10288	131	18	dehydrogenase	dehydrogenase	NOUN
cusj-10288	131	19	deficiency	deficiency	NOUN
cusj-10288	131	20	,	,	PUNCT
cusj-10288	131	21	a	a	DET
cusj-10288	131	22	component	component	NOUN
cusj-10288	131	23	of	of	ADP
cusj-10288	131	24	both	both	CCONJ
cusj-10288	131	25	the	the	DET
cusj-10288	131	26	krebs	krebs	NOUN
cusj-10288	131	27	cycle	cycle	NOUN
cusj-10288	131	28	and	and	CCONJ
cusj-10288	131	29	the	the	DET
cusj-10288	131	30	electron	electron	NOUN
cusj-10288	131	31	transport	transport	NOUN
cusj-10288	131	32	chain	chain	NOUN
cusj-10288	131	33	's	's	PART
cusj-10288	131	34	complex	complex	PROPN
cusj-10288	131	35	ii	ii	NOUN
cusj-10288	131	36	.	.	PUNCT
cusj-10288	132	1	as	as	SCONJ
cusj-10288	132	2	compared	compare	VERB
cusj-10288	132	3	to	to	ADP
cusj-10288	132	4	levels	level	NOUN
cusj-10288	132	5	in	in	ADP
cusj-10288	132	6	matched	match	VERB
cusj-10288	132	7	control	control	NOUN
cusj-10288	132	8	brains	brain	NOUN
cusj-10288	132	9	,	,	PUNCT
cusj-10288	132	10	hd	hd	VERB
cusj-10288	132	11	brains	brain	NOUN
cusj-10288	132	12	demonstrated	demonstrate	VERB
cusj-10288	132	13	a	a	DET
cusj-10288	132	14	significant	significant	ADJ
cusj-10288	132	15	decrease	decrease	NOUN
cusj-10288	132	16	in	in	ADP
cusj-10288	132	17	complex	complex	ADJ
cusj-10288	132	18	ii	ii	NOUN
cusj-10288	132	19	activity	activity	NOUN
cusj-10288	132	20	in	in	ADP
cusj-10288	132	21	the	the	DET
cusj-10288	132	22	caudate	caudate	ADJ
cusj-10288	132	23	nucleus	nucleus	NOUN
cusj-10288	132	24	(	(	PUNCT
cusj-10288	132	25	roughly	roughly	ADV
cusj-10288	132	26	50	50	NUM
cusj-10288	132	27	%	%	NOUN
cusj-10288	132	28	)	)	PUNCT
cusj-10288	133	1	[	[	X
cusj-10288	133	2	67	67	NUM
cusj-10288	133	3	]	]	PUNCT
cusj-10288	133	4	.	.	PUNCT
cusj-10288	134	1	in	in	ADP
cusj-10288	134	2	addition	addition	NOUN
cusj-10288	134	3	to	to	ADP
cusj-10288	134	4	reductions	reduction	NOUN
cusj-10288	134	5	in	in	ADP
cusj-10288	134	6	complex	complex	ADJ
cusj-10288	134	7	ii	ii	NOUN
cusj-10288	134	8	activity	activity	NOUN
cusj-10288	134	9	,	,	PUNCT
cusj-10288	134	10	complex	complex	ADJ
cusj-10288	134	11	iii	iii	NUM
cusj-10288	134	12	activity	activity	NOUN
cusj-10288	134	13	in	in	ADP
cusj-10288	134	14	the	the	DET
cusj-10288	134	15	caudate	caudate	NOUN
cusj-10288	134	16	and	and	CCONJ
cusj-10288	134	17	putamen	putaman	NOUN
cusj-10288	134	18	,	,	PUNCT
cusj-10288	134	19	as	as	ADV
cusj-10288	134	20	well	well	ADV
cusj-10288	134	21	as	as	ADP
cusj-10288	134	22	complex	complex	ADJ
cusj-10288	134	23	iv	iv	NUM
cusj-10288	134	24	activity	activity	NOUN
cusj-10288	134	25	in	in	ADP
cusj-10288	134	26	the	the	DET
cusj-10288	134	27	putamen	putaman	NOUN
cusj-10288	134	28	,	,	PUNCT
cusj-10288	134	29	have	have	AUX
cusj-10288	134	30	decreased	decrease	VERB
cusj-10288	134	31	as	as	ADV
cusj-10288	134	32	well	well	ADV
cusj-10288	134	33	[	[	X
cusj-10288	134	34	67	67	NUM
cusj-10288	134	35	]	]	PUNCT
cusj-10288	134	36	.	.	PUNCT
cusj-10288	135	1	in	in	ADP
cusj-10288	135	2	spite	spite	NOUN
cusj-10288	135	3	of	of	ADP
cusj-10288	135	4	this	this	PRON
cusj-10288	135	5	,	,	PUNCT
cusj-10288	135	6	since	since	SCONJ
cusj-10288	135	7	most	most	ADJ
cusj-10288	135	8	of	of	ADP
cusj-10288	135	9	these	these	DET
cusj-10288	135	10	patients	patient	NOUN
cusj-10288	135	11	suffered	suffer	VERB
cusj-10288	135	12	from	from	ADP
cusj-10288	135	13	advanced	advanced	ADJ
cusj-10288	135	14	neuropathy	neuropathy	ADJ
cusj-10288	135	15	,	,	PUNCT
cusj-10288	135	16	including	include	VERB
cusj-10288	135	17	severe	severe	ADJ
cusj-10288	135	18	striatal	striatal	ADJ
cusj-10288	135	19	atrophy	atrophy	NOUN
cusj-10288	135	20	(	(	PUNCT
cusj-10288	135	21	pathological	pathological	ADJ
cusj-10288	135	22	grades	grade	NOUN
cusj-10288	135	23	3	3	NUM
cusj-10288	135	24	and	and	CCONJ
cusj-10288	135	25	4	4	NUM
cusj-10288	135	26	of	of	ADP
cusj-10288	135	27	hd	hd	NOUN
cusj-10288	135	28	)	)	PUNCT
cusj-10288	135	29	,	,	PUNCT
cusj-10288	135	30	mutations	mutation	NOUN
cusj-10288	135	31	in	in	ADP
cusj-10288	135	32	mitochondrial	mitochondrial	ADJ
cusj-10288	135	33	sources	source	NOUN
cusj-10288	135	34	(	(	PUNCT
cusj-10288	135	35	i.e.	i.e.	X
cusj-10288	135	36	,	,	PUNCT
cusj-10288	135	37	glial	glial	ADJ
cusj-10288	135	38	,	,	PUNCT
cusj-10288	135	39	neuronal	neuronal	ADJ
cusj-10288	135	40	,	,	PUNCT
cusj-10288	135	41	etc	etc	X
cusj-10288	135	42	.	.	X
cusj-10288	135	43	)	)	PUNCT
cusj-10288	135	44	may	may	AUX
cusj-10288	135	45	have	have	AUX
cusj-10288	135	46	occurred	occur	VERB
cusj-10288	135	47	[	[	X
cusj-10288	135	48	59	59	NUM
cusj-10288	135	49	]	]	PUNCT
cusj-10288	135	50	.	.	PUNCT
cusj-10288	136	1	2	2	X
cusj-10288	136	2	.	.	X
cusj-10288	136	3	oxidative	oxidative	ADJ
cusj-10288	136	4	stress	stress	NOUN
cusj-10288	136	5	due	due	ADP
cusj-10288	136	6	to	to	ADP
cusj-10288	136	7	ros	ros	PROPN
cusj-10288	136	8	reactive	reactive	ADJ
cusj-10288	136	9	oxygen	oxygen	NOUN
cusj-10288	136	10	species	specie	NOUN
cusj-10288	136	11	(	(	PUNCT
cusj-10288	136	12	ros	ros	PROPN
cusj-10288	136	13	)	)	PUNCT
cusj-10288	136	14	are	be	AUX
cusj-10288	136	15	produced	produce	VERB
cusj-10288	136	16	in	in	ADP
cusj-10288	136	17	excess	excess	NOUN
cusj-10288	136	18	in	in	ADP
cusj-10288	136	19	the	the	DET
cusj-10288	136	20	body	body	NOUN
cusj-10288	136	21	,	,	PUNCT
cusj-10288	136	22	which	which	PRON
cusj-10288	136	23	results	result	VERB
cusj-10288	136	24	in	in	ADP
cusj-10288	136	25	oxidative	oxidative	ADJ
cusj-10288	136	26	stress	stress	NOUN
cusj-10288	136	27	when	when	SCONJ
cusj-10288	136	28	the	the	DET
cusj-10288	136	29	body	body	NOUN
cusj-10288	136	30	is	be	AUX
cusj-10288	136	31	unable	unable	ADJ
cusj-10288	136	32	to	to	PART
cusj-10288	136	33	detoxify	detoxify	VERB
cusj-10288	136	34	them	they	PRON
cusj-10288	136	35	and	and	CCONJ
cusj-10288	136	36	repair	repair	VERB
cusj-10288	136	37	the	the	DET
cusj-10288	136	38	damage	damage	NOUN
cusj-10288	136	39	they	they	PRON
cusj-10288	136	40	cause	cause	VERB
cusj-10288	136	41	.	.	PUNCT
cusj-10288	137	1	animal	animal	NOUN
cusj-10288	137	2	models	model	NOUN
cusj-10288	137	3	with	with	ADP
cusj-10288	137	4	hd	hd	NOUN
cusj-10288	137	5	showed	show	VERB
cusj-10288	137	6	increased	increase	VERB
cusj-10288	137	7	levels	level	NOUN
cusj-10288	137	8	of	of	ADP
cusj-10288	137	9	malondialdehyde	malondialdehyde	NOUN
cusj-10288	137	10	,	,	PUNCT
cusj-10288	137	11	8hydroxydeoxyguanosine	8hydroxydeoxyguanosine	NUM
cusj-10288	137	12	,	,	PUNCT
cusj-10288	137	13	3	3	NUM
cusj-10288	137	14	-	-	NUM
cusj-10288	137	15	nitrotyrosine	nitrotyrosine	NOUN
cusj-10288	137	16	,	,	PUNCT
cusj-10288	137	17	and	and	CCONJ
cusj-10288	137	18	heme	heme	NOUN
cusj-10288	137	19	oxygenase	oxygenase	NOUN
cusj-10288	137	20	oxidative	oxidative	ADJ
cusj-10288	137	21	damage	damage	NOUN
cusj-10288	137	22	products	product	NOUN
cusj-10288	137	23	,	,	PUNCT
cusj-10288	137	24	and	and	CCONJ
cusj-10288	137	25	free	free	ADJ
cusj-10288	137	26	radicals	radical	NOUN
cusj-10288	137	27	in	in	ADP
cusj-10288	137	28	the	the	DET
cusj-10288	137	29	areas	area	NOUN
cusj-10288	137	30	of	of	ADP
cusj-10288	137	31	degeneration	degeneration	NOUN
cusj-10288	137	32	in	in	ADP
cusj-10288	137	33	the	the	DET
cusj-10288	137	34	brain	brain	NOUN
cusj-10288	137	35	of	of	ADP
cusj-10288	137	36	hd	hd	NOUN
cusj-10288	137	37	affected	affect	VERB
cusj-10288	137	38	individuals	individual	NOUN
cusj-10288	137	39	which	which	PRON
cusj-10288	137	40	propose	propose	VERB
cusj-10288	137	41	that	that	SCONJ
cusj-10288	137	42	oxidative	oxidative	ADJ
cusj-10288	137	43	stress	stress	NOUN
cusj-10288	137	44	is	be	AUX
cusj-10288	137	45	connected	connect	VERB
cusj-10288	137	46	with	with	ADP
cusj-10288	137	47	the	the	DET
cusj-10288	137	48	disease	disease	NOUN
cusj-10288	137	49	,	,	PUNCT
cusj-10288	137	50	either	either	CCONJ
cusj-10288	137	51	as	as	ADP
cusj-10288	137	52	a	a	DET
cusj-10288	137	53	primary	primary	ADJ
cusj-10288	137	54	event	event	NOUN
cusj-10288	137	55	or	or	CCONJ
cusj-10288	137	56	a	a	DET
cusj-10288	137	57	secondary	secondary	ADJ
cusj-10288	137	58	component	component	NOUN
cusj-10288	137	59	of	of	ADP
cusj-10288	137	60	the	the	DET
cusj-10288	137	61	cascade	cascade	NOUN
cusj-10288	137	62	processes	process	NOUN
cusj-10288	137	63	of	of	ADP
cusj-10288	137	64	cell	cell	NOUN
cusj-10288	137	65	death	death	NOUN
cusj-10288	138	1	[	[	X
cusj-10288	138	2	67	67	NUM
cusj-10288	138	3	]	]	PUNCT
cusj-10288	138	4	.	.	PUNCT
cusj-10288	139	1	there	there	PRON
cusj-10288	139	2	is	be	VERB
cusj-10288	139	3	ample	ample	ADJ
cusj-10288	139	4	evidence	evidence	NOUN
cusj-10288	139	5	that	that	PRON
cusj-10288	139	6	oxidative	oxidative	ADJ
cusj-10288	139	7	damage	damage	NOUN
cusj-10288	139	8	subsidizes	subsidize	VERB
cusj-10288	139	9	significantly	significantly	ADV
cusj-10288	139	10	to	to	ADP
cusj-10288	139	11	the	the	DET
cusj-10288	139	12	pathogenesis	pathogenesis	NOUN
cusj-10288	139	13	of	of	ADP
cusj-10288	139	14	neurodegenerative	neurodegenerative	ADJ
cusj-10288	139	15	diseases	disease	NOUN
cusj-10288	139	16	such	such	ADJ
cusj-10288	139	17	as	as	ADP
cusj-10288	139	18	hd	hd	NOUN
cusj-10288	139	19	[	[	X
cusj-10288	139	20	60	60	NUM
cusj-10288	139	21	]	]	PUNCT
cusj-10288	139	22	.	.	PUNCT
cusj-10288	140	1	3	3	X
cusj-10288	140	2	.	.	X
cusj-10288	140	3	apoptosis	apoptosis	NOUN
cusj-10288	140	4	there	there	PRON
cusj-10288	140	5	is	be	VERB
cusj-10288	140	6	a	a	DET
cusj-10288	140	7	link	link	NOUN
cusj-10288	140	8	between	between	ADP
cusj-10288	140	9	the	the	DET
cusj-10288	140	10	pathogenic	pathogenic	ADJ
cusj-10288	140	11	mechanism	mechanism	NOUN
cusj-10288	140	12	of	of	ADP
cusj-10288	140	13	apoptosis	apoptosis	NOUN
cusj-10288	140	14	and	and	CCONJ
cusj-10288	140	15	chronic	chronic	ADJ
cusj-10288	140	16	neurodegenerative	neurodegenerative	ADJ
cusj-10288	140	17	diseases	disease	NOUN
cusj-10288	140	18	like	like	ADP
cusj-10288	140	19	hd	hd	NOUN
cusj-10288	140	20	[	[	X
cusj-10288	140	21	61	61	NUM
cusj-10288	140	22	]	]	PUNCT
cusj-10288	140	23	.	.	PUNCT
cusj-10288	141	1	caspases	caspase	NOUN
cusj-10288	141	2	are	be	AUX
cusj-10288	141	3	cysteine	cysteine	NOUN
cusj-10288	141	4	-	-	PUNCT
cusj-10288	141	5	dependent	dependent	ADJ
cusj-10288	141	6	,	,	PUNCT
cusj-10288	141	7	aspartatespecific	aspartatespecific	ADJ
cusj-10288	141	8	proteases	protease	NOUN
cusj-10288	141	9	that	that	PRON
cusj-10288	141	10	initiate	initiate	VERB
cusj-10288	141	11	and	and	CCONJ
cusj-10288	141	12	execute	execute	VERB
cusj-10288	141	13	apoptosis	apoptosis	NOUN
cusj-10288	141	14	.	.	PUNCT
cusj-10288	142	1	a	a	DET
cusj-10288	142	2	transcriptional	transcriptional	NOUN
cusj-10288	142	3	up	up	ADP
cusj-10288	142	4	regulation	regulation	NOUN
cusj-10288	142	5	of	of	ADP
cusj-10288	142	6	caspase-1	caspase-1	PROPN
cusj-10288	142	7	,	,	PUNCT
cusj-10288	142	8	caspase-3	caspase-3	NUM
cusj-10288	142	9	,	,	PUNCT
cusj-10288	142	10	and	and	CCONJ
cusj-10288	142	11	caspase-9	caspase-9	PROPN
cusj-10288	142	12	in	in	ADP
cusj-10288	142	13	hd	hd	NOUN
cusj-10288	142	14	patients	patient	NOUN
cusj-10288	142	15	as	as	ADV
cusj-10288	142	16	well	well	ADV
cusj-10288	142	17	as	as	ADP
cusj-10288	142	18	in	in	ADP
cusj-10288	142	19	animal	animal	NOUN
cusj-10288	142	20	models	model	NOUN
cusj-10288	142	21	of	of	ADP
cusj-10288	142	22	hd	hd	NOUN
cusj-10288	142	23	has	have	AUX
cusj-10288	142	24	been	be	AUX
cusj-10288	142	25	reported	report	VERB
cusj-10288	142	26	[	[	PUNCT
cusj-10288	142	27	62	62	NUM
cusj-10288	142	28	]	]	PUNCT
cusj-10288	142	29	.	.	PUNCT
cusj-10288	143	1	amyloidogenic	amyloidogenic	ADJ
cusj-10288	143	2	mutant	mutant	NOUN
cusj-10288	143	3	huntingtin	huntingtin	NOUN
cusj-10288	143	4	(	(	PUNCT
cusj-10288	143	5	mhtt	mhtt	NOUN
cusj-10288	143	6	)	)	PUNCT
cusj-10288	143	7	has	have	AUX
cusj-10288	143	8	been	be	AUX
cusj-10288	143	9	confirmed	confirm	VERB
cusj-10288	143	10	to	to	PART
cusj-10288	143	11	induce	induce	VERB
cusj-10288	143	12	apoptosis	apoptosis	NOUN
cusj-10288	143	13	in	in	ADP
cusj-10288	143	14	hd	hd	NOUN
cusj-10288	143	15	patients	patient	NOUN
cusj-10288	143	16	[	[	X
cusj-10288	143	17	63	63	NUM
cusj-10288	143	18	]	]	PUNCT
cusj-10288	143	19	.	.	PUNCT
cusj-10288	144	1	4	4	X
cusj-10288	144	2	.	.	X
cusj-10288	144	3	neuroinflammation	neuroinflammation	NOUN
cusj-10288	144	4	by	by	ADP
cusj-10288	144	5	discharging	discharge	VERB
cusj-10288	144	6	cell	cell	NOUN
cusj-10288	144	7	mediators	mediator	NOUN
cusj-10288	144	8	that	that	PRON
cusj-10288	144	9	combat	combat	VERB
cusj-10288	144	10	foreign	foreign	ADJ
cusj-10288	144	11	substances	substance	NOUN
cusj-10288	144	12	and	and	CCONJ
cusj-10288	144	13	prevent	prevent	VERB
cusj-10288	144	14	infections	infection	NOUN
cusj-10288	144	15	,	,	PUNCT
cusj-10288	144	16	the	the	DET
cusj-10288	144	17	inflammatory	inflammatory	ADJ
cusj-10288	144	18	process	process	NOUN
cusj-10288	144	19	safeguards	safeguard	VERB
cusj-10288	144	20	our	our	PRON
cusj-10288	144	21	bodies	body	NOUN
cusj-10288	144	22	from	from	ADP
cusj-10288	144	23	harm	harm	NOUN
cusj-10288	144	24	and	and	CCONJ
cusj-10288	144	25	disease	disease	NOUN
cusj-10288	144	26	.	.	PUNCT
cusj-10288	145	1	neuroinflammation	neuroinflammation	NOUN
cusj-10288	145	2	does	do	AUX
cusj-10288	145	3	not	not	PART
cusj-10288	145	4	directly	directly	ADV
cusj-10288	145	5	correlate	correlate	VERB
cusj-10288	145	6	with	with	ADP
cusj-10288	145	7	hd	hd	NOUN
cusj-10288	145	8	progression	progression	NOUN
cusj-10288	145	9	,	,	PUNCT
cusj-10288	145	10	despite	despite	SCONJ
cusj-10288	145	11	inflammatory	inflammatory	ADJ
cusj-10288	145	12	processes	process	NOUN
cusj-10288	145	13	being	be	AUX
cusj-10288	145	14	evidently	evidently	ADV
cusj-10288	145	15	confirmed	confirm	VERB
cusj-10288	145	16	in	in	ADP
cusj-10288	145	17	its	its	PRON
cusj-10288	145	18	pathophysiology	pathophysiology	NOUN
cusj-10288	145	19	.	.	PUNCT
cusj-10288	146	1	post	post	ADJ
cusj-10288	146	2	-	-	ADJ
cusj-10288	146	3	mortem	mortem	ADJ
cusj-10288	146	4	studies	study	NOUN
cusj-10288	146	5	of	of	ADP
cusj-10288	146	6	degenerating	degenerate	VERB
cusj-10288	146	7	neurons	neuron	NOUN
cusj-10288	146	8	in	in	ADP
cusj-10288	146	9	hd	hd	PROPN
cusj-10288	146	10	have	have	AUX
cusj-10288	146	11	discovered	discover	VERB
cusj-10288	146	12	high	high	ADJ
cusj-10288	146	13	levels	level	NOUN
cusj-10288	146	14	of	of	ADP
cusj-10288	146	15	activated	activate	VERB
cusj-10288	146	16	microglia	microglia	NOUN
cusj-10288	146	17	and	and	CCONJ
cusj-10288	146	18	macrophages	macrophage	NOUN
cusj-10288	146	19	as	as	ADV
cusj-10288	146	20	well	well	ADV
cusj-10288	146	21	as	as	ADP
cusj-10288	146	22	elevated	elevated	ADJ
cusj-10288	146	23	levels	level	NOUN
cusj-10288	146	24	of	of	ADP
cusj-10288	146	25	il-6	il-6	NUM
cusj-10288	146	26	,	,	PUNCT
cusj-10288	146	27	il1	il1	PROPN
cusj-10288	146	28	,	,	PUNCT
cusj-10288	146	29	and	and	CCONJ
cusj-10288	146	30	tnfin	tnfin	VERB
cusj-10288	146	31	the	the	DET
cusj-10288	146	32	plasma	plasma	NOUN
cusj-10288	146	33	and	and	CCONJ
cusj-10288	146	34	striatum	striatum	NOUN
cusj-10288	146	35	of	of	ADP
cusj-10288	146	36	hd	hd	NOUN
cusj-10288	146	37	patients	patient	NOUN
cusj-10288	146	38	[	[	X
cusj-10288	146	39	67	67	NUM
cusj-10288	146	40	]	]	PUNCT
cusj-10288	146	41	.	.	PUNCT
cusj-10288	147	1	microglial	microglial	ADJ
cusj-10288	147	2	cells	cell	NOUN
cusj-10288	147	3	may	may	AUX
cusj-10288	147	4	identify	identify	VERB
cusj-10288	147	5	the	the	DET
cusj-10288	147	6	pathogenic	pathogenic	ADJ
cusj-10288	147	7	mhtt	mhtt	NOUN
cusj-10288	147	8	aggregates	aggregate	NOUN
cusj-10288	147	9	as	as	ADP
cusj-10288	147	10	foreign	foreign	ADJ
cusj-10288	147	11	substances	substance	NOUN
cusj-10288	147	12	,	,	PUNCT
cusj-10288	147	13	resulting	result	VERB
cusj-10288	147	14	in	in	ADP
cusj-10288	147	15	neuro	neuro	NOUN
cusj-10288	147	16	-	-	PUNCT
cusj-10288	147	17	inflammation	inflammation	NOUN
cusj-10288	147	18	[	[	X
cusj-10288	147	19	64	64	NUM
cusj-10288	147	20	]	]	PUNCT
cusj-10288	147	21	.	.	PUNCT
cusj-10288	148	1	5	5	X
cusj-10288	148	2	.	.	X
cusj-10288	148	3	neurotoxicity	neurotoxicity	NOUN
cusj-10288	148	4	disproportionate	disproportionate	ADJ
cusj-10288	148	5	glutamate	glutamate	NOUN
cusj-10288	148	6	neurotransmission	neurotransmission	NOUN
cusj-10288	148	7	leads	lead	VERB
cusj-10288	148	8	to	to	ADP
cusj-10288	148	9	excitotoxic	excitotoxic	ADJ
cusj-10288	148	10	neuronal	neuronal	ADJ
cusj-10288	148	11	death	death	NOUN
cusj-10288	148	12	,	,	PUNCT
cusj-10288	148	13	which	which	PRON
cusj-10288	148	14	is	be	AUX
cusj-10288	148	15	supplemented	supplement	VERB
cusj-10288	148	16	by	by	ADP
cusj-10288	148	17	insistent	insistent	ADJ
cusj-10288	148	18	intracellular	intracellular	ADJ
cusj-10288	148	19	calcium	calcium	NOUN
cusj-10288	148	20	level	level	NOUN
cusj-10288	148	21	elevation	elevation	NOUN
cusj-10288	148	22	[	[	X
cusj-10288	148	23	65	65	NUM
cusj-10288	148	24	]	]	PUNCT
cusj-10288	148	25	.	.	PUNCT
cusj-10288	149	1	as	as	SCONJ
cusj-10288	149	2	nmda	nmda	ADJ
cusj-10288	149	3	(	(	PUNCT
cusj-10288	149	4	n	n	CCONJ
cusj-10288	149	5	-	-	PUNCT
cusj-10288	149	6	methyl	methyl	NOUN
cusj-10288	149	7	-	-	PUNCT
cusj-10288	149	8	d	d	NOUN
cusj-10288	149	9	-	-	ADJ
cusj-10288	149	10	aspartic	aspartic	ADJ
cusj-10288	149	11	acid	acid	NOUN
cusj-10288	149	12	)	)	PUNCT
cusj-10288	149	13	receptors	receptor	NOUN
cusj-10288	149	14	are	be	AUX
cusj-10288	149	15	over	over	ADP
cusj-10288	149	16	activated	activate	VERB
cusj-10288	149	17	by	by	ADP
cusj-10288	149	18	excited	excited	ADJ
cusj-10288	149	19	amino	amino	NOUN
cusj-10288	149	20	acids	acid	NOUN
cusj-10288	149	21	,	,	PUNCT
cusj-10288	149	22	free	free	ADJ
cusj-10288	149	23	radicals	radical	NOUN
cusj-10288	149	24	are	be	AUX
cusj-10288	149	25	formed	form	VERB
cusj-10288	149	26	and	and	CCONJ
cusj-10288	149	27	mitochondrial	mitochondrial	ADJ
cusj-10288	149	28	percolumbia	percolumbia	NOUN
cusj-10288	149	29	undergraduate	undergraduate	NOUN
cusj-10288	149	30	science	science	PROPN
cusj-10288	149	31	journal	journal	PROPN
cusj-10288	149	32	vol	vol	NOUN
cusj-10288	149	33	.	.	PROPN
cusj-10288	150	1	17	17	NUM
cusj-10288	150	2	,	,	PUNCT
cusj-10288	150	3	2023	2023	NUM
cusj-10288	150	4	datta	datta	NOUN
cusj-10288	150	5	23	23	NUM
cusj-10288	150	6	meability	meability	NOUN
cusj-10288	150	7	transition	transition	NOUN
cusj-10288	150	8	pores	pore	NOUN
cusj-10288	150	9	are	be	AUX
cusj-10288	150	10	unlocked	unlock	VERB
cusj-10288	150	11	,	,	PUNCT
cusj-10288	150	12	both	both	PRON
cusj-10288	150	13	of	of	ADP
cusj-10288	150	14	which	which	PRON
cusj-10288	150	15	are	be	AUX
cusj-10288	150	16	lethal	lethal	ADJ
cusj-10288	150	17	.	.	PUNCT
cusj-10288	151	1	the	the	DET
cusj-10288	151	2	role	role	NOUN
cusj-10288	151	3	of	of	ADP
cusj-10288	151	4	neurotoxicity	neurotoxicity	NOUN
cusj-10288	151	5	has	have	AUX
cusj-10288	151	6	been	be	AUX
cusj-10288	151	7	documented	document	VERB
cusj-10288	151	8	as	as	ADP
cusj-10288	151	9	significant	significant	ADJ
cusj-10288	151	10	since	since	SCONJ
cusj-10288	151	11	the	the	DET
cusj-10288	151	12	undeviating	undeviating	ADJ
cusj-10288	151	13	injection	injection	NOUN
cusj-10288	151	14	of	of	ADP
cusj-10288	151	15	acids	acid	NOUN
cusj-10288	151	16	such	such	ADJ
cusj-10288	151	17	as	as	ADP
cusj-10288	151	18	qa	qa	PROPN
cusj-10288	151	19	and	and	CCONJ
cusj-10288	151	20	kainic	kainic	ADJ
cusj-10288	151	21	acid	acid	PROPN
cusj-10288	151	22	causes	cause	VERB
cusj-10288	151	23	neuro	neuro	NOUN
cusj-10288	151	24	-	-	PUNCT
cusj-10288	151	25	degeneration	degeneration	NOUN
cusj-10288	151	26	of	of	ADP
cusj-10288	151	27	gabaergic	gabaergic	ADJ
cusj-10288	151	28	msn	msn	NOUN
cusj-10288	151	29	in	in	ADP
cusj-10288	151	30	hd	hd	PROPN
cusj-10288	151	31	[	[	X
cusj-10288	151	32	66	66	NUM
cusj-10288	151	33	]	]	PUNCT
cusj-10288	151	34	.	.	PUNCT
cusj-10288	152	1	advances	advance	NOUN
cusj-10288	152	2	in	in	ADP
cusj-10288	152	3	huntington	huntington	PROPN
cusj-10288	152	4	's	's	PART
cusj-10288	152	5	disease	disease	NOUN
cusj-10288	152	6	therapy	therapy	NOUN
cusj-10288	152	7	the	the	DET
cusj-10288	152	8	htt	htt	NOUN
cusj-10288	152	9	gene	gene	NOUN
cusj-10288	152	10	mutations	mutation	NOUN
cusj-10288	152	11	that	that	PRON
cusj-10288	152	12	cause	cause	VERB
cusj-10288	152	13	hd	hd	NOUN
cusj-10288	152	14	are	be	AUX
cusj-10288	152	15	still	still	ADV
cusj-10288	152	16	not	not	PART
cusj-10288	152	17	fully	fully	ADV
cusj-10288	152	18	understood	understand	VERB
cusj-10288	152	19	,	,	PUNCT
cusj-10288	152	20	but	but	CCONJ
cusj-10288	152	21	research	research	NOUN
cusj-10288	152	22	on	on	ADP
cusj-10288	152	23	the	the	DET
cusj-10288	152	24	molecular	molecular	ADJ
cusj-10288	152	25	mechanisms	mechanism	NOUN
cusj-10288	152	26	behind	behind	ADP
cusj-10288	152	27	them	they	PRON
cusj-10288	152	28	is	be	AUX
cusj-10288	152	29	very	very	ADV
cusj-10288	152	30	promising	promising	ADJ
cusj-10288	152	31	and	and	CCONJ
cusj-10288	152	32	could	could	AUX
cusj-10288	152	33	lead	lead	VERB
cusj-10288	152	34	to	to	ADP
cusj-10288	152	35	a	a	DET
cusj-10288	152	36	cure	cure	NOUN
cusj-10288	152	37	.	.	PUNCT
cusj-10288	153	1	currently	currently	ADV
cusj-10288	153	2	,	,	PUNCT
cusj-10288	153	3	there	there	PRON
cusj-10288	153	4	are	be	VERB
cusj-10288	153	5	no	no	DET
cusj-10288	153	6	neuroprotective	neuroprotective	ADJ
cusj-10288	153	7	therapies	therapy	NOUN
cusj-10288	153	8	that	that	PRON
cusj-10288	153	9	can	can	AUX
cusj-10288	153	10	prevent	prevent	VERB
cusj-10288	153	11	or	or	CCONJ
cusj-10288	153	12	slow	slow	VERB
cusj-10288	153	13	down	down	ADP
cusj-10288	153	14	the	the	DET
cusj-10288	153	15	disease	disease	NOUN
cusj-10288	153	16	,	,	PUNCT
cusj-10288	153	17	and	and	CCONJ
cusj-10288	153	18	the	the	DET
cusj-10288	153	19	only	only	ADJ
cusj-10288	153	20	treatments	treatment	NOUN
cusj-10288	153	21	available	available	ADJ
cusj-10288	153	22	are	be	AUX
cusj-10288	153	23	symptomatic	symptomatic	ADJ
cusj-10288	153	24	[	[	X
cusj-10288	153	25	67	67	NUM
cusj-10288	153	26	]	]	PUNCT
cusj-10288	153	27	.	.	PUNCT
cusj-10288	154	1	one	one	NUM
cusj-10288	154	2	of	of	ADP
cusj-10288	154	3	the	the	DET
cusj-10288	154	4	main	main	ADJ
cusj-10288	154	5	causes	cause	NOUN
cusj-10288	154	6	of	of	ADP
cusj-10288	154	7	hd	hd	NOUN
cusj-10288	154	8	is	be	AUX
cusj-10288	154	9	the	the	DET
cusj-10288	154	10	toxicity	toxicity	NOUN
cusj-10288	154	11	of	of	ADP
cusj-10288	154	12	mhtt	mhtt	NOUN
cusj-10288	154	13	,	,	PUNCT
cusj-10288	154	14	the	the	DET
cusj-10288	154	15	mutant	mutant	ADJ
cusj-10288	154	16	form	form	NOUN
cusj-10288	154	17	of	of	ADP
cusj-10288	154	18	the	the	DET
cusj-10288	154	19	htt	htt	NOUN
cusj-10288	154	20	protein	protein	NOUN
cusj-10288	154	21	,	,	PUNCT
cusj-10288	154	22	which	which	PRON
cusj-10288	154	23	is	be	AUX
cusj-10288	154	24	produced	produce	VERB
cusj-10288	154	25	by	by	ADP
cusj-10288	154	26	the	the	DET
cusj-10288	154	27	mutated	mutate	VERB
cusj-10288	154	28	gene	gene	NOUN
cusj-10288	154	29	.	.	PUNCT
cusj-10288	155	1	therefore	therefore	ADV
cusj-10288	155	2	,	,	PUNCT
cusj-10288	155	3	reducing	reduce	VERB
cusj-10288	155	4	the	the	DET
cusj-10288	155	5	expression	expression	NOUN
cusj-10288	155	6	of	of	ADP
cusj-10288	155	7	mhtt	mhtt	NOUN
cusj-10288	155	8	,	,	PUNCT
cusj-10288	155	9	either	either	CCONJ
cusj-10288	155	10	by	by	ADP
cusj-10288	155	11	lowering	lower	VERB
cusj-10288	155	12	the	the	DET
cusj-10288	155	13	levels	level	NOUN
cusj-10288	155	14	of	of	ADP
cusj-10288	155	15	htt	htt	PROPN
cusj-10288	155	16	mrna	mrna	PROPN
cusj-10288	155	17	or	or	CCONJ
cusj-10288	155	18	the	the	DET
cusj-10288	155	19	protein	protein	NOUN
cusj-10288	155	20	itself	itself	PRON
cusj-10288	155	21	,	,	PUNCT
cusj-10288	155	22	is	be	AUX
cusj-10288	155	23	a	a	DET
cusj-10288	155	24	potential	potential	ADJ
cusj-10288	155	25	strategy	strategy	NOUN
cusj-10288	155	26	to	to	PART
cusj-10288	155	27	treat	treat	VERB
cusj-10288	155	28	hd	hd	NOUN
cusj-10288	155	29	[	[	X
cusj-10288	155	30	68	68	NUM
cusj-10288	155	31	]	]	PUNCT
cusj-10288	155	32	.	.	PUNCT
cusj-10288	156	1	some	some	DET
cusj-10288	156	2	studies	study	NOUN
cusj-10288	156	3	have	have	AUX
cusj-10288	156	4	suggested	suggest	VERB
cusj-10288	156	5	that	that	SCONJ
cusj-10288	156	6	gene	gene	NOUN
cusj-10288	156	7	-	-	PUNCT
cusj-10288	156	8	silencing	silence	VERB
cusj-10288	156	9	techniques	technique	NOUN
cusj-10288	156	10	that	that	PRON
cusj-10288	156	11	target	target	VERB
cusj-10288	156	12	the	the	DET
cusj-10288	156	13	cag	cag	PROPN
cusj-10288	156	14	repeats	repeat	NOUN
cusj-10288	156	15	in	in	ADP
cusj-10288	156	16	the	the	DET
cusj-10288	156	17	htt	htt	NOUN
cusj-10288	156	18	gene	gene	NOUN
cusj-10288	156	19	,	,	PUNCT
cusj-10288	156	20	which	which	PRON
cusj-10288	156	21	are	be	AUX
cusj-10288	156	22	responsible	responsible	ADJ
cusj-10288	156	23	for	for	ADP
cusj-10288	156	24	the	the	DET
cusj-10288	156	25	mutation	mutation	NOUN
cusj-10288	156	26	,	,	PUNCT
cusj-10288	156	27	could	could	AUX
cusj-10288	156	28	improve	improve	VERB
cusj-10288	156	29	the	the	DET
cusj-10288	156	30	functional	functional	ADJ
cusj-10288	156	31	,	,	PUNCT
cusj-10288	156	32	motor	motor	NOUN
cusj-10288	156	33	and	and	CCONJ
cusj-10288	156	34	cognitive	cognitive	ADJ
cusj-10288	156	35	outcomes	outcome	NOUN
cusj-10288	156	36	of	of	ADP
cusj-10288	156	37	hd	hd	NOUN
cusj-10288	156	38	patients	patient	NOUN
cusj-10288	156	39	,	,	PUNCT
cusj-10288	156	40	but	but	CCONJ
cusj-10288	156	41	not	not	PART
cusj-10288	156	42	their	their	PRON
cusj-10288	156	43	weight	weight	NOUN
cusj-10288	156	44	loss	loss	NOUN
cusj-10288	156	45	[	[	X
cusj-10288	156	46	67	67	NUM
cusj-10288	156	47	,	,	PUNCT
cusj-10288	156	48	69	69	NUM
cusj-10288	156	49	]	]	PUNCT
cusj-10288	156	50	.	.	PUNCT
cusj-10288	157	1	these	these	DET
cusj-10288	157	2	techniques	technique	NOUN
cusj-10288	157	3	involve	involve	VERB
cusj-10288	157	4	using	use	VERB
cusj-10288	157	5	different	different	ADJ
cusj-10288	157	6	types	type	NOUN
cusj-10288	157	7	of	of	ADP
cusj-10288	157	8	dnabinding	dnabinding	NOUN
cusj-10288	157	9	elements	element	NOUN
cusj-10288	157	10	,	,	PUNCT
cusj-10288	157	11	such	such	ADJ
cusj-10288	157	12	as	as	ADP
cusj-10288	157	13	zinc	zinc	NOUN
cusj-10288	157	14	-	-	PUNCT
cusj-10288	157	15	finger	finger	NOUN
cusj-10288	157	16	proteins	protein	NOUN
cusj-10288	157	17	,	,	PUNCT
cusj-10288	157	18	nucleases	nuclease	NOUN
cusj-10288	157	19	,	,	PUNCT
cusj-10288	157	20	epigenetic	epigenetic	ADJ
cusj-10288	157	21	modulators	modulator	NOUN
cusj-10288	157	22	,	,	PUNCT
cusj-10288	157	23	or	or	CCONJ
cusj-10288	157	24	transcription	transcription	NOUN
cusj-10288	157	25	factors	factor	NOUN
cusj-10288	157	26	,	,	PUNCT
cusj-10288	157	27	to	to	ADP
cusj-10288	157	28	either	either	PRON
cusj-10288	157	29	block	block	NOUN
cusj-10288	157	30	,	,	PUNCT
cusj-10288	157	31	disrupt	disrupt	VERB
cusj-10288	157	32	,	,	PUNCT
cusj-10288	157	33	or	or	CCONJ
cusj-10288	157	34	correct	correct	VERB
cusj-10288	157	35	the	the	DET
cusj-10288	157	36	mutant	mutant	ADJ
cusj-10288	157	37	gene	gene	NOUN
cusj-10288	157	38	.	.	PUNCT
cusj-10288	158	1	for	for	ADP
cusj-10288	158	2	example	example	NOUN
cusj-10288	158	3	,	,	PUNCT
cusj-10288	158	4	zinc	zinc	NOUN
cusj-10288	158	5	-	-	PUNCT
cusj-10288	158	6	finger	finger	NOUN
cusj-10288	158	7	transcriptional	transcriptional	NOUN
cusj-10288	158	8	repressors	repressor	NOUN
cusj-10288	158	9	can	can	AUX
cusj-10288	158	10	bind	bind	VERB
cusj-10288	158	11	to	to	ADP
cusj-10288	158	12	the	the	DET
cusj-10288	158	13	dna	dna	NOUN
cusj-10288	158	14	and	and	CCONJ
cusj-10288	158	15	prevent	prevent	VERB
cusj-10288	158	16	its	its	PRON
cusj-10288	158	17	transcription	transcription	NOUN
cusj-10288	158	18	,	,	PUNCT
cusj-10288	158	19	while	while	SCONJ
cusj-10288	158	20	zinc	zinc	NOUN
cusj-10288	158	21	-	-	PUNCT
cusj-10288	158	22	finger	finger	NOUN
cusj-10288	158	23	nucleases	nuclease	NOUN
cusj-10288	158	24	can	can	AUX
cusj-10288	158	25	cut	cut	VERB
cusj-10288	158	26	and	and	CCONJ
cusj-10288	158	27	edit	edit	VERB
cusj-10288	158	28	the	the	DET
cusj-10288	158	29	dna	dna	NOUN
cusj-10288	159	1	[	[	X
cusj-10288	159	2	67,70	67,70	NOUN
cusj-10288	159	3	]	]	PUNCT
cusj-10288	159	4	.	.	PUNCT
cusj-10288	160	1	another	another	DET
cusj-10288	160	2	example	example	NOUN
cusj-10288	160	3	of	of	ADP
cusj-10288	160	4	a	a	DET
cusj-10288	160	5	genome	genome	NOUN
cusj-10288	160	6	editing	editing	NOUN
cusj-10288	160	7	technique	technique	NOUN
cusj-10288	160	8	is	be	AUX
cusj-10288	160	9	crispr	crispr	ADJ
cusj-10288	160	10	/	/	SYM
cusj-10288	160	11	cas9	cas9	NOUN
cusj-10288	160	12	,	,	PUNCT
cusj-10288	160	13	which	which	PRON
cusj-10288	160	14	can	can	AUX
cusj-10288	160	15	also	also	ADV
cusj-10288	160	16	target	target	VERB
cusj-10288	160	17	and	and	CCONJ
cusj-10288	160	18	modify	modify	VERB
cusj-10288	160	19	the	the	DET
cusj-10288	160	20	htt	htt	NOUN
cusj-10288	160	21	gene	gene	NOUN
cusj-10288	160	22	.	.	PUNCT
cusj-10288	161	1	these	these	DET
cusj-10288	161	2	approaches	approach	NOUN
cusj-10288	161	3	have	have	VERB
cusj-10288	161	4	the	the	DET
cusj-10288	161	5	advantage	advantage	NOUN
cusj-10288	161	6	of	of	ADP
cusj-10288	161	7	permanently	permanently	ADV
cusj-10288	161	8	correcting	correct	VERB
cusj-10288	161	9	the	the	DET
cusj-10288	161	10	cag	cag	PROPN
cusj-10288	161	11	expansion	expansion	NOUN
cusj-10288	161	12	that	that	PRON
cusj-10288	161	13	causes	cause	VERB
cusj-10288	161	14	hd	hd	VERB
cusj-10288	161	15	.	.	PUNCT
cusj-10288	162	1	another	another	DET
cusj-10288	162	2	way	way	NOUN
cusj-10288	162	3	of	of	ADP
cusj-10288	162	4	reducing	reduce	VERB
cusj-10288	162	5	mhtt	mhtt	NOUN
cusj-10288	162	6	expression	expression	NOUN
cusj-10288	162	7	is	be	AUX
cusj-10288	162	8	by	by	ADP
cusj-10288	162	9	using	use	VERB
cusj-10288	162	10	antisense	antisense	NOUN
cusj-10288	162	11	oligonucleotides	oligonucleotide	NOUN
cusj-10288	162	12	(	(	PUNCT
cusj-10288	162	13	asos	asos	NOUN
cusj-10288	162	14	)	)	PUNCT
cusj-10288	162	15	,	,	PUNCT
cusj-10288	162	16	which	which	PRON
cusj-10288	162	17	are	be	AUX
cusj-10288	162	18	synthetic	synthetic	ADJ
cusj-10288	162	19	molecules	molecule	NOUN
cusj-10288	162	20	that	that	PRON
cusj-10288	162	21	bind	bind	VERB
cusj-10288	162	22	to	to	ADP
cusj-10288	162	23	the	the	DET
cusj-10288	162	24	htt	htt	NOUN
cusj-10288	162	25	mrna	mrna	PROPN
cusj-10288	162	26	and	and	CCONJ
cusj-10288	162	27	trigger	trigger	VERB
cusj-10288	162	28	its	its	PRON
cusj-10288	162	29	degradation	degradation	NOUN
cusj-10288	162	30	by	by	ADP
cusj-10288	162	31	an	an	DET
cusj-10288	162	32	enzyme	enzyme	NOUN
cusj-10288	162	33	called	call	VERB
cusj-10288	162	34	rnase	rnase	PROPN
cusj-10288	162	35	h1	h1	PROPN
cusj-10288	162	36	[	[	X
cusj-10288	162	37	71	71	NUM
cusj-10288	162	38	]	]	PUNCT
cusj-10288	162	39	.	.	PUNCT
cusj-10288	163	1	asos	asos	PROPN
cusj-10288	163	2	can	can	AUX
cusj-10288	163	3	reach	reach	VERB
cusj-10288	163	4	the	the	DET
cusj-10288	163	5	central	central	ADJ
cusj-10288	163	6	nervous	nervous	ADJ
cusj-10288	163	7	system	system	NOUN
cusj-10288	163	8	without	without	ADP
cusj-10288	163	9	needing	need	VERB
cusj-10288	163	10	a	a	DET
cusj-10288	163	11	viral	viral	ADJ
cusj-10288	163	12	or	or	CCONJ
cusj-10288	163	13	lipid	lipid	NOUN
cusj-10288	163	14	carrier	carrier	NOUN
cusj-10288	163	15	,	,	PUNCT
cusj-10288	163	16	and	and	CCONJ
cusj-10288	163	17	they	they	PRON
cusj-10288	163	18	are	be	AUX
cusj-10288	163	19	easy	easy	ADJ
cusj-10288	163	20	to	to	PART
cusj-10288	163	21	develop	develop	VERB
cusj-10288	163	22	[	[	X
cusj-10288	163	23	67	67	NUM
cusj-10288	163	24	]	]	PUNCT
cusj-10288	163	25	.	.	PUNCT
cusj-10288	164	1	a	a	DET
cusj-10288	164	2	clinical	clinical	ADJ
cusj-10288	164	3	trial	trial	NOUN
cusj-10288	164	4	by	by	ADP
cusj-10288	164	5	tabrizi	tabrizi	NOUN
cusj-10288	164	6	et	et	NOUN
cusj-10288	164	7	al	al	PROPN
cusj-10288	165	1	[	[	X
cusj-10288	165	2	72	72	NUM
cusj-10288	165	3	]	]	PUNCT
cusj-10288	165	4	used	use	VERB
cusj-10288	165	5	an	an	DET
cusj-10288	165	6	aso	aso	NOUN
cusj-10288	165	7	called	call	VERB
cusj-10288	165	8	ionis	ionis	NOUN
cusj-10288	165	9	-	-	PUNCT
cusj-10288	165	10	httrx	httrx	NOUN
cusj-10288	165	11	to	to	PART
cusj-10288	165	12	lower	lower	VERB
cusj-10288	165	13	the	the	DET
cusj-10288	165	14	levels	level	NOUN
cusj-10288	165	15	of	of	ADP
cusj-10288	165	16	mhtt	mhtt	PROPN
cusj-10288	165	17	in	in	ADP
cusj-10288	165	18	the	the	DET
cusj-10288	165	19	cerebrospinal	cerebrospinal	ADJ
cusj-10288	165	20	fluid	fluid	NOUN
cusj-10288	165	21	of	of	ADP
cusj-10288	165	22	34	34	NUM
cusj-10288	165	23	hd	hd	NOUN
cusj-10288	165	24	patients	patient	NOUN
cusj-10288	165	25	,	,	PUNCT
cusj-10288	165	26	who	who	PRON
cusj-10288	165	27	received	receive	VERB
cusj-10288	165	28	doses	dose	NOUN
cusj-10288	165	29	ranging	range	VERB
cusj-10288	165	30	from	from	ADP
cusj-10288	165	31	10	10	NUM
cusj-10288	165	32	to	to	PART
cusj-10288	165	33	120	120	NUM
cusj-10288	165	34	mg	mg	NOUN
cusj-10288	165	35	,	,	PUNCT
cusj-10288	165	36	and	and	CCONJ
cusj-10288	165	37	compared	compare	VERB
cusj-10288	165	38	them	they	PRON
cusj-10288	165	39	with	with	ADP
cusj-10288	165	40	a	a	DET
cusj-10288	165	41	placebo	placebo	NOUN
cusj-10288	165	42	group	group	NOUN
cusj-10288	165	43	.	.	PUNCT
cusj-10288	166	1	the	the	DET
cusj-10288	166	2	results	result	NOUN
cusj-10288	166	3	showed	show	VERB
cusj-10288	166	4	that	that	SCONJ
cusj-10288	166	5	the	the	DET
cusj-10288	166	6	mhtt	mhtt	PROPN
cusj-10288	166	7	reduction	reduction	NOUN
cusj-10288	166	8	was	be	AUX
cusj-10288	166	9	dose	dose	NOUN
cusj-10288	166	10	-	-	PUNCT
cusj-10288	166	11	dependent	dependent	ADJ
cusj-10288	166	12	[	[	X
cusj-10288	166	13	72	72	NUM
cusj-10288	166	14	]	]	PUNCT
cusj-10288	166	15	.	.	PUNCT
cusj-10288	167	1	a	a	DET
cusj-10288	167	2	similar	similar	ADJ
cusj-10288	167	3	method	method	NOUN
cusj-10288	167	4	of	of	ADP
cusj-10288	167	5	post	post	ADJ
cusj-10288	167	6	-	-	ADJ
cusj-10288	167	7	transcriptional	transcriptional	ADJ
cusj-10288	167	8	gene	gene	NOUN
cusj-10288	167	9	suppression	suppression	NOUN
cusj-10288	167	10	is	be	AUX
cusj-10288	167	11	rna	rna	NOUN
cusj-10288	167	12	interference	interference	NOUN
cusj-10288	167	13	(	(	PUNCT
cusj-10288	167	14	rnai	rnai	PROPN
cusj-10288	167	15	)	)	PUNCT
cusj-10288	167	16	,	,	PUNCT
cusj-10288	167	17	which	which	PRON
cusj-10288	167	18	uses	use	VERB
cusj-10288	167	19	noncoding	noncode	VERB
cusj-10288	167	20	double	double	ADJ
cusj-10288	167	21	-	-	PUNCT
cusj-10288	167	22	stranded	strand	VERB
cusj-10288	167	23	rna	rna	NOUN
cusj-10288	167	24	sequences	sequence	NOUN
cusj-10288	167	25	to	to	PART
cusj-10288	167	26	silence	silence	VERB
cusj-10288	167	27	specific	specific	ADJ
cusj-10288	167	28	genes	gene	NOUN
cusj-10288	167	29	.	.	PUNCT
cusj-10288	168	1	rnai	rnai	PROPN
cusj-10288	168	2	can	can	AUX
cusj-10288	168	3	be	be	AUX
cusj-10288	168	4	achieved	achieve	VERB
cusj-10288	168	5	by	by	ADP
cusj-10288	168	6	using	use	VERB
cusj-10288	168	7	different	different	ADJ
cusj-10288	168	8	types	type	NOUN
cusj-10288	168	9	of	of	ADP
cusj-10288	168	10	rna	rna	NOUN
cusj-10288	168	11	molecules	molecule	NOUN
cusj-10288	168	12	,	,	PUNCT
cusj-10288	168	13	such	such	ADJ
cusj-10288	168	14	as	as	ADP
cusj-10288	168	15	sirnas	sirna	NOUN
cusj-10288	168	16	,	,	PUNCT
cusj-10288	168	17	shrnas	shrna	NOUN
cusj-10288	168	18	,	,	PUNCT
cusj-10288	168	19	or	or	CCONJ
cusj-10288	168	20	artificial	artificial	ADJ
cusj-10288	168	21	mirnas	mirna	NOUN
cusj-10288	168	22	,	,	PUNCT
cusj-10288	168	23	which	which	PRON
cusj-10288	168	24	have	have	AUX
cusj-10288	168	25	been	be	AUX
cusj-10288	168	26	shown	show	VERB
cusj-10288	168	27	to	to	PART
cusj-10288	168	28	reduce	reduce	VERB
cusj-10288	168	29	the	the	DET
cusj-10288	168	30	hd	hd	NOUN
cusj-10288	168	31	symptoms	symptom	NOUN
cusj-10288	168	32	[	[	X
cusj-10288	168	33	67	67	NUM
cusj-10288	168	34	]	]	PUNCT
cusj-10288	168	35	.	.	PUNCT
cusj-10288	169	1	rnai	rnai	PROPN
cusj-10288	169	2	is	be	AUX
cusj-10288	169	3	also	also	ADV
cusj-10288	169	4	a	a	DET
cusj-10288	169	5	promising	promising	ADJ
cusj-10288	169	6	technique	technique	NOUN
cusj-10288	169	7	for	for	ADP
cusj-10288	169	8	many	many	ADJ
cusj-10288	169	9	other	other	ADJ
cusj-10288	169	10	diseases	disease	NOUN
cusj-10288	169	11	.	.	PUNCT
cusj-10288	170	1	one	one	NUM
cusj-10288	170	2	of	of	ADP
cusj-10288	170	3	the	the	DET
cusj-10288	170	4	main	main	ADJ
cusj-10288	170	5	approaches	approach	NOUN
cusj-10288	170	6	for	for	ADP
cusj-10288	170	7	treating	treat	VERB
cusj-10288	170	8	hd	hd	NOUN
cusj-10288	170	9	is	be	AUX
cusj-10288	170	10	to	to	PART
cusj-10288	170	11	reduce	reduce	VERB
cusj-10288	170	12	the	the	DET
cusj-10288	170	13	synthesis	synthesis	NOUN
cusj-10288	170	14	of	of	ADP
cusj-10288	170	15	the	the	DET
cusj-10288	170	16	mutant	mutant	ADJ
cusj-10288	170	17	htt	htt	NOUN
cusj-10288	170	18	(	(	PUNCT
cusj-10288	170	19	mhtt	mhtt	PROPN
cusj-10288	170	20	)	)	PUNCT
cusj-10288	170	21	protein	protein	NOUN
cusj-10288	170	22	,	,	PUNCT
cusj-10288	170	23	which	which	PRON
cusj-10288	170	24	forms	form	VERB
cusj-10288	170	25	toxic	toxic	ADJ
cusj-10288	170	26	aggregates	aggregate	NOUN
cusj-10288	170	27	in	in	ADP
cusj-10288	170	28	the	the	DET
cusj-10288	170	29	brain	brain	NOUN
cusj-10288	170	30	.	.	PUNCT
cusj-10288	171	1	this	this	PRON
cusj-10288	171	2	can	can	AUX
cusj-10288	171	3	be	be	AUX
cusj-10288	171	4	achieved	achieve	VERB
cusj-10288	171	5	by	by	ADP
cusj-10288	171	6	using	use	VERB
cusj-10288	171	7	rna	rna	NOUN
cusj-10288	171	8	interference	interference	NOUN
cusj-10288	171	9	(	(	PUNCT
cusj-10288	171	10	rnai	rnai	NOUN
cusj-10288	171	11	)	)	PUNCT
cusj-10288	171	12	techniques	technique	NOUN
cusj-10288	171	13	,	,	PUNCT
cusj-10288	171	14	which	which	PRON
cusj-10288	171	15	involve	involve	VERB
cusj-10288	171	16	the	the	DET
cusj-10288	171	17	use	use	NOUN
cusj-10288	171	18	of	of	ADP
cusj-10288	171	19	small	small	ADJ
cusj-10288	171	20	rna	rna	NOUN
cusj-10288	171	21	molecules	molecule	NOUN
cusj-10288	171	22	that	that	PRON
cusj-10288	171	23	bind	bind	VERB
cusj-10288	171	24	to	to	ADP
cusj-10288	171	25	the	the	DET
cusj-10288	171	26	mhtt	mhtt	PROPN
cusj-10288	171	27	mrna	mrna	PROPN
cusj-10288	171	28	and	and	CCONJ
cusj-10288	171	29	prevent	prevent	VERB
cusj-10288	171	30	its	its	PRON
cusj-10288	171	31	translation	translation	NOUN
cusj-10288	171	32	.	.	PUNCT
cusj-10288	172	1	several	several	ADJ
cusj-10288	172	2	types	type	NOUN
cusj-10288	172	3	of	of	ADP
cusj-10288	172	4	rna	rna	NOUN
cusj-10288	172	5	molecules	molecule	NOUN
cusj-10288	172	6	have	have	AUX
cusj-10288	172	7	been	be	AUX
cusj-10288	172	8	used	use	VERB
cusj-10288	172	9	for	for	ADP
cusj-10288	172	10	rnai	rnai	PROPN
cusj-10288	172	11	,	,	PUNCT
cusj-10288	172	12	such	such	ADJ
cusj-10288	172	13	as	as	ADP
cusj-10288	172	14	short	short	ADJ
cusj-10288	172	15	hairpin	hairpin	NOUN
cusj-10288	172	16	rna	rna	NOUN
cusj-10288	172	17	(	(	PUNCT
cusj-10288	172	18	shrna	shrna	NOUN
cusj-10288	172	19	)	)	PUNCT
cusj-10288	172	20	,	,	PUNCT
cusj-10288	172	21	small	small	ADJ
cusj-10288	172	22	interfering	interfere	VERB
cusj-10288	172	23	rna	rna	NOUN
cusj-10288	172	24	(	(	PUNCT
cusj-10288	172	25	sirna	sirna	PROPN
cusj-10288	172	26	)	)	PUNCT
cusj-10288	172	27	,	,	PUNCT
cusj-10288	172	28	and	and	CCONJ
cusj-10288	172	29	microrna	microrna	PROPN
cusj-10288	172	30	(	(	PUNCT
cusj-10288	172	31	mirna	mirna	PROPN
cusj-10288	172	32	)	)	PUNCT
cusj-10288	173	1	[	[	X
cusj-10288	173	2	67	67	NUM
cusj-10288	173	3	]	]	PUNCT
cusj-10288	173	4	.	.	PUNCT
cusj-10288	174	1	these	these	DET
cusj-10288	174	2	molecules	molecule	NOUN
cusj-10288	174	3	have	have	AUX
cusj-10288	174	4	been	be	AUX
cusj-10288	174	5	delivered	deliver	VERB
cusj-10288	174	6	to	to	ADP
cusj-10288	174	7	the	the	DET
cusj-10288	174	8	brain	brain	NOUN
cusj-10288	174	9	of	of	ADP
cusj-10288	174	10	hd	hd	NOUN
cusj-10288	174	11	animal	animal	NOUN
cusj-10288	174	12	models	model	NOUN
cusj-10288	174	13	using	use	VERB
cusj-10288	174	14	viral	viral	ADJ
cusj-10288	174	15	vectors	vector	NOUN
cusj-10288	174	16	,	,	PUNCT
cusj-10288	174	17	such	such	ADJ
cusj-10288	174	18	as	as	ADP
cusj-10288	174	19	adeno	adeno	NOUN
cusj-10288	174	20	-	-	PUNCT
cusj-10288	174	21	associated	associate	VERB
cusj-10288	174	22	virus	virus	NOUN
cusj-10288	174	23	(	(	PUNCT
cusj-10288	174	24	aav	aav	PROPN
cusj-10288	174	25	)	)	PUNCT
cusj-10288	174	26	,	,	PUNCT
cusj-10288	174	27	which	which	PRON
cusj-10288	174	28	contain	contain	VERB
cusj-10288	174	29	enhancers	enhancer	NOUN
cusj-10288	174	30	and	and	CCONJ
cusj-10288	174	31	promoters	promoter	NOUN
cusj-10288	174	32	to	to	PART
cusj-10288	174	33	drive	drive	VERB
cusj-10288	174	34	the	the	DET
cusj-10288	174	35	expression	expression	NOUN
cusj-10288	174	36	of	of	ADP
cusj-10288	174	37	the	the	DET
cusj-10288	174	38	rna	rna	NOUN
cusj-10288	174	39	molecules	molecule	NOUN
cusj-10288	174	40	.	.	PUNCT
cusj-10288	175	1	the	the	DET
cusj-10288	175	2	first	first	ADJ
cusj-10288	175	3	trials	trial	NOUN
cusj-10288	175	4	of	of	ADP
cusj-10288	175	5	rnai	rnai	PROPN
cusj-10288	175	6	for	for	ADP
cusj-10288	175	7	hd	hd	NOUN
cusj-10288	175	8	were	be	AUX
cusj-10288	175	9	performed	perform	VERB
cusj-10288	175	10	in	in	ADP
cusj-10288	175	11	rodents	rodent	NOUN
cusj-10288	175	12	two	two	NUM
cusj-10288	175	13	decades	decade	NOUN
cusj-10288	175	14	ago	ago	ADV
cusj-10288	175	15	.	.	PUNCT
cusj-10288	176	1	it	it	PRON
cusj-10288	176	2	is	be	AUX
cusj-10288	176	3	seen	see	VERB
cusj-10288	176	4	that	that	DET
cusj-10288	176	5	shrna	shrna	NOUN
cusj-10288	176	6	targeting	target	VERB
cusj-10288	176	7	mhtt	mhtt	NOUN
cusj-10288	176	8	reduced	reduce	VERB
cusj-10288	176	9	its	its	PRON
cusj-10288	176	10	synthesis	synthesis	NOUN
cusj-10288	176	11	and	and	CCONJ
cusj-10288	176	12	prevented	prevent	VERB
cusj-10288	176	13	the	the	DET
cusj-10288	176	14	formation	formation	NOUN
cusj-10288	176	15	of	of	ADP
cusj-10288	176	16	inclusions	inclusion	NOUN
cusj-10288	176	17	,	,	PUNCT
cusj-10288	176	18	gait	gait	ADJ
cusj-10288	176	19	deficits	deficit	NOUN
cusj-10288	176	20	,	,	PUNCT
cusj-10288	176	21	and	and	CCONJ
cusj-10288	176	22	rotarod	rotarod	NOUN
cusj-10288	176	23	dysfunction	dysfunction	NOUN
cusj-10288	176	24	in	in	ADP
cusj-10288	176	25	mice	mouse	NOUN
cusj-10288	176	26	,	,	PUNCT
cusj-10288	176	27	in	in	ADP
cusj-10288	176	28	recent	recent	ADJ
cusj-10288	176	29	studies	study	NOUN
cusj-10288	176	30	[	[	X
cusj-10288	176	31	67	67	NUM
cusj-10288	176	32	]	]	PUNCT
cusj-10288	176	33	.	.	PUNCT
cusj-10288	177	1	similarly	similarly	ADV
cusj-10288	177	2	,	,	PUNCT
cusj-10288	177	3	columbia	columbia	PROPN
cusj-10288	177	4	undergraduate	undergraduate	PROPN
cusj-10288	177	5	science	science	PROPN
cusj-10288	177	6	journal	journal	PROPN
cusj-10288	177	7	vol	vol	NOUN
cusj-10288	177	8	.	.	PROPN
cusj-10288	177	9	17	17	NUM
cusj-10288	177	10	,	,	PUNCT
cusj-10288	177	11	2023	2023	NUM
cusj-10288	177	12	datta	datta	NOUN
cusj-10288	177	13	24	24	NUM
cusj-10288	177	14	sirna	sirna	PROPN
cusj-10288	177	15	injected	inject	VERB
cusj-10288	177	16	into	into	ADP
cusj-10288	177	17	the	the	DET
cusj-10288	177	18	mouse	mouse	NOUN
cusj-10288	177	19	striatum	striatum	NOUN
cusj-10288	177	20	prolonged	prolong	VERB
cusj-10288	177	21	the	the	DET
cusj-10288	177	22	survival	survival	NOUN
cusj-10288	177	23	of	of	ADP
cusj-10288	177	24	striatal	striatal	ADJ
cusj-10288	177	25	neurons	neuron	NOUN
cusj-10288	177	26	,	,	PUNCT
cusj-10288	177	27	reduced	reduce	VERB
cusj-10288	177	28	mhtt	mhtt	PROPN
cusj-10288	177	29	aggregates	aggregate	NOUN
cusj-10288	177	30	,	,	PUNCT
cusj-10288	177	31	and	and	CCONJ
cusj-10288	177	32	prevented	prevent	VERB
cusj-10288	177	33	motor	motor	NOUN
cusj-10288	177	34	dysfunction	dysfunction	NOUN
cusj-10288	178	1	[	[	X
cusj-10288	178	2	73	73	NUM
cusj-10288	178	3	]	]	PUNCT
cusj-10288	178	4	.	.	PUNCT
cusj-10288	179	1	these	these	DET
cusj-10288	179	2	results	result	NOUN
cusj-10288	179	3	were	be	AUX
cusj-10288	179	4	replicated	replicate	VERB
cusj-10288	179	5	in	in	ADP
cusj-10288	179	6	multiple	multiple	ADJ
cusj-10288	179	7	animal	animal	NOUN
cusj-10288	179	8	systems	system	NOUN
cusj-10288	179	9	,	,	PUNCT
cusj-10288	179	10	such	such	ADJ
cusj-10288	179	11	as	as	ADP
cusj-10288	179	12	rats	rat	NOUN
cusj-10288	179	13	,	,	PUNCT
cusj-10288	179	14	monkeys	monkey	NOUN
cusj-10288	179	15	,	,	PUNCT
cusj-10288	179	16	and	and	CCONJ
cusj-10288	179	17	sheep	sheep	NOUN
cusj-10288	179	18	[	[	X
cusj-10288	179	19	74	74	NUM
cusj-10288	179	20	]	]	PUNCT
cusj-10288	179	21	.	.	PUNCT
cusj-10288	180	1	a	a	DET
cusj-10288	180	2	recent	recent	ADJ
cusj-10288	180	3	study	study	NOUN
cusj-10288	180	4	used	use	VERB
cusj-10288	180	5	a	a	DET
cusj-10288	180	6	single	single	ADJ
cusj-10288	180	7	-	-	PUNCT
cusj-10288	180	8	stranded	strand	VERB
cusj-10288	180	9	sirna	sirna	PROPN
cusj-10288	180	10	(	(	PUNCT
cusj-10288	180	11	sssirna	sssirna	PROPN
cusj-10288	180	12	)	)	PUNCT
cusj-10288	180	13	for	for	ADP
cusj-10288	180	14	rnai	rnai	PROPN
cusj-10288	180	15	and	and	CCONJ
cusj-10288	180	16	achieved	achieve	VERB
cusj-10288	180	17	a	a	DET
cusj-10288	180	18	selective	selective	ADJ
cusj-10288	180	19	decrease	decrease	NOUN
cusj-10288	180	20	of	of	ADP
cusj-10288	180	21	cag	cag	PROPN
cusj-10288	180	22	-	-	PUNCT
cusj-10288	180	23	expanded	expand	VERB
cusj-10288	180	24	htt	htt	NOUN
cusj-10288	180	25	protein	protein	NOUN
cusj-10288	180	26	in	in	ADP
cusj-10288	180	27	various	various	ADJ
cusj-10288	180	28	regions	region	NOUN
cusj-10288	180	29	of	of	ADP
cusj-10288	180	30	the	the	DET
cusj-10288	180	31	mouse	mouse	NOUN
cusj-10288	180	32	brain	brain	NOUN
cusj-10288	181	1	[	[	X
cusj-10288	181	2	75	75	NUM
cusj-10288	181	3	]	]	PUNCT
cusj-10288	181	4	.	.	PUNCT
cusj-10288	182	1	another	another	DET
cusj-10288	182	2	type	type	NOUN
cusj-10288	182	3	of	of	ADP
cusj-10288	182	4	rna	rna	NOUN
cusj-10288	182	5	molecule	molecule	NOUN
cusj-10288	182	6	that	that	PRON
cusj-10288	182	7	has	have	AUX
cusj-10288	182	8	been	be	AUX
cusj-10288	182	9	used	use	VERB
cusj-10288	182	10	for	for	ADP
cusj-10288	182	11	the	the	DET
cusj-10288	182	12	suppression	suppression	NOUN
cusj-10288	182	13	of	of	ADP
cusj-10288	182	14	mhtt	mhtt	PROPN
cusj-10288	182	15	is	be	AUX
cusj-10288	182	16	mirna	mirna	NOUN
cusj-10288	182	17	,	,	PUNCT
cusj-10288	182	18	which	which	PRON
cusj-10288	182	19	is	be	AUX
cusj-10288	182	20	a	a	DET
cusj-10288	182	21	natural	natural	ADJ
cusj-10288	182	22	regulator	regulator	NOUN
cusj-10288	182	23	of	of	ADP
cusj-10288	182	24	gene	gene	NOUN
cusj-10288	182	25	expression	expression	NOUN
cusj-10288	182	26	.	.	PUNCT
cusj-10288	183	1	mirnas	mirna	NOUN
cusj-10288	183	2	have	have	AUX
cusj-10288	183	3	been	be	AUX
cusj-10288	183	4	shown	show	VERB
cusj-10288	183	5	to	to	PART
cusj-10288	183	6	have	have	VERB
cusj-10288	183	7	promising	promising	ADJ
cusj-10288	183	8	effects	effect	NOUN
cusj-10288	183	9	in	in	ADP
cusj-10288	183	10	genetically	genetically	ADV
cusj-10288	183	11	modified	modify	VERB
cusj-10288	183	12	mice	mouse	NOUN
cusj-10288	183	13	with	with	ADP
cusj-10288	183	14	hd	hd	NOUN
cusj-10288	183	15	;	;	PUNCT
cusj-10288	183	16	for	for	ADP
cusj-10288	183	17	example	example	NOUN
cusj-10288	183	18	,	,	PUNCT
cusj-10288	183	19	one	one	NUM
cusj-10288	183	20	study	study	NOUN
cusj-10288	183	21	reported	report	VERB
cusj-10288	183	22	that	that	SCONJ
cusj-10288	183	23	mirna	mirna	NOUN
cusj-10288	183	24	-	-	PUNCT
cusj-10288	183	25	mediated	mediate	VERB
cusj-10288	183	26	knockdown	knockdown	NOUN
cusj-10288	183	27	of	of	ADP
cusj-10288	183	28	mhtt	mhtt	PROPN
cusj-10288	183	29	prevented	prevent	VERB
cusj-10288	183	30	regional	regional	ADJ
cusj-10288	183	31	cortical	cortical	ADJ
cusj-10288	183	32	and	and	CCONJ
cusj-10288	183	33	striatal	striatal	ADJ
cusj-10288	183	34	atrophy	atrophy	NOUN
cusj-10288	183	35	and	and	CCONJ
cusj-10288	183	36	reduced	reduce	VERB
cusj-10288	183	37	weight	weight	NOUN
cusj-10288	183	38	loss	loss	NOUN
cusj-10288	183	39	[	[	X
cusj-10288	183	40	76	76	NUM
cusj-10288	183	41	]	]	X
cusj-10288	183	42	.	.	PUNCT
cusj-10288	184	1	most	most	ADJ
cusj-10288	184	2	of	of	ADP
cusj-10288	184	3	the	the	DET
cusj-10288	184	4	rnai	rnai	PROPN
cusj-10288	184	5	techniques	technique	NOUN
cusj-10288	184	6	do	do	AUX
cusj-10288	184	7	not	not	PART
cusj-10288	184	8	completely	completely	ADV
cusj-10288	184	9	eliminate	eliminate	VERB
cusj-10288	184	10	the	the	DET
cusj-10288	184	11	production	production	NOUN
cusj-10288	184	12	of	of	ADP
cusj-10288	184	13	mhtt	mhtt	NOUN
cusj-10288	184	14	,	,	PUNCT
cusj-10288	184	15	but	but	CCONJ
cusj-10288	184	16	only	only	ADV
cusj-10288	184	17	reduce	reduce	VERB
cusj-10288	184	18	it	it	PRON
cusj-10288	184	19	to	to	ADP
cusj-10288	184	20	a	a	DET
cusj-10288	184	21	certain	certain	ADJ
cusj-10288	184	22	extent	extent	NOUN
cusj-10288	184	23	.	.	PUNCT
cusj-10288	185	1	therefore	therefore	ADV
cusj-10288	185	2	,	,	PUNCT
cusj-10288	185	3	another	another	DET
cusj-10288	185	4	possible	possible	ADJ
cusj-10288	185	5	therapeutic	therapeutic	ADJ
cusj-10288	185	6	approach	approach	NOUN
cusj-10288	185	7	is	be	AUX
cusj-10288	185	8	to	to	PART
cusj-10288	185	9	overexpress	overexpress	VERB
cusj-10288	185	10	the	the	DET
cusj-10288	185	11	wild	wild	ADJ
cusj-10288	185	12	-	-	PUNCT
cusj-10288	185	13	type	type	NOUN
cusj-10288	185	14	htt	htt	NOUN
cusj-10288	185	15	,	,	PUNCT
cusj-10288	185	16	which	which	PRON
cusj-10288	185	17	may	may	AUX
cusj-10288	185	18	have	have	VERB
cusj-10288	185	19	a	a	DET
cusj-10288	185	20	protective	protective	ADJ
cusj-10288	185	21	role	role	NOUN
cusj-10288	185	22	against	against	ADP
cusj-10288	185	23	the	the	DET
cusj-10288	185	24	toxic	toxic	ADJ
cusj-10288	185	25	effects	effect	NOUN
cusj-10288	185	26	of	of	ADP
cusj-10288	185	27	mhtt	mhtt	NOUN
cusj-10288	185	28	.	.	PUNCT
cusj-10288	186	1	early	early	ADJ
cusj-10288	186	2	trials	trial	NOUN
cusj-10288	186	3	of	of	ADP
cusj-10288	186	4	this	this	DET
cusj-10288	186	5	strategy	strategy	NOUN
cusj-10288	186	6	showed	show	VERB
cusj-10288	186	7	that	that	SCONJ
cusj-10288	186	8	inserting	insert	VERB
cusj-10288	186	9	the	the	DET
cusj-10288	186	10	wild	wild	ADJ
cusj-10288	186	11	-	-	PUNCT
cusj-10288	186	12	type	type	NOUN
cusj-10288	186	13	htt	htt	NOUN
cusj-10288	186	14	into	into	ADP
cusj-10288	186	15	mammalian	mammalian	ADJ
cusj-10288	186	16	cells	cell	NOUN
cusj-10288	186	17	that	that	PRON
cusj-10288	186	18	expressed	express	VERB
cusj-10288	186	19	mhtt	mhtt	NOUN
cusj-10288	186	20	reduced	reduce	VERB
cusj-10288	186	21	cell	cell	NOUN
cusj-10288	186	22	death	death	NOUN
cusj-10288	186	23	[	[	X
cusj-10288	186	24	77	77	NUM
cusj-10288	186	25	]	]	PUNCT
cusj-10288	186	26	.	.	PUNCT
cusj-10288	187	1	several	several	ADJ
cusj-10288	187	2	natural	natural	ADJ
cusj-10288	187	3	and	and	CCONJ
cusj-10288	187	4	synthetic	synthetic	ADJ
cusj-10288	187	5	compounds	compound	NOUN
cusj-10288	187	6	have	have	AUX
cusj-10288	187	7	been	be	AUX
cusj-10288	187	8	suggested	suggest	VERB
cusj-10288	187	9	as	as	ADP
cusj-10288	187	10	potential	potential	ADJ
cusj-10288	187	11	candidates	candidate	NOUN
cusj-10288	187	12	for	for	ADP
cusj-10288	187	13	the	the	DET
cusj-10288	187	14	treatment	treatment	NOUN
cusj-10288	187	15	of	of	ADP
cusj-10288	187	16	hd	hd	NOUN
cusj-10288	187	17	and	and	CCONJ
cusj-10288	187	18	other	other	ADJ
cusj-10288	187	19	neurodegenerative	neurodegenerative	ADJ
cusj-10288	187	20	disorders	disorder	NOUN
cusj-10288	187	21	.	.	PUNCT
cusj-10288	188	1	one	one	NUM
cusj-10288	188	2	of	of	ADP
cusj-10288	188	3	the	the	DET
cusj-10288	188	4	most	most	ADV
cusj-10288	188	5	widely	widely	ADV
cusj-10288	188	6	studied	study	VERB
cusj-10288	188	7	compounds	compound	NOUN
cusj-10288	188	8	for	for	ADP
cusj-10288	188	9	hd	hd	NOUN
cusj-10288	188	10	is	be	AUX
cusj-10288	188	11	tetrabenazine	tetrabenazine	NOUN
cusj-10288	188	12	(	(	PUNCT
cusj-10288	188	13	tbz	tbz	NOUN
cusj-10288	188	14	)	)	PUNCT
cusj-10288	188	15	,	,	PUNCT
cusj-10288	188	16	which	which	PRON
cusj-10288	188	17	is	be	AUX
cusj-10288	188	18	an	an	DET
cusj-10288	188	19	inhibitor	inhibitor	NOUN
cusj-10288	188	20	of	of	ADP
cusj-10288	188	21	the	the	DET
cusj-10288	188	22	vesicular	vesicular	ADJ
cusj-10288	188	23	monoamine	monoamine	NOUN
cusj-10288	188	24	transporter	transporter	NOUN
cusj-10288	188	25	2	2	NUM
cusj-10288	188	26	(	(	PUNCT
cusj-10288	188	27	vmat2	vmat2	PROPN
cusj-10288	188	28	)	)	PUNCT
cusj-10288	188	29	that	that	PRON
cusj-10288	188	30	blocks	block	VERB
cusj-10288	188	31	the	the	DET
cusj-10288	188	32	uptake	uptake	NOUN
cusj-10288	188	33	of	of	ADP
cusj-10288	188	34	dopamine	dopamine	NOUN
cusj-10288	188	35	into	into	ADP
cusj-10288	188	36	vesicles	vesicle	NOUN
cusj-10288	188	37	[	[	X
cusj-10288	188	38	67	67	NUM
cusj-10288	188	39	]	]	PUNCT
cusj-10288	188	40	.	.	PUNCT
cusj-10288	189	1	tbz	tbz	PROPN
cusj-10288	189	2	has	have	AUX
cusj-10288	189	3	been	be	AUX
cusj-10288	189	4	shown	show	VERB
cusj-10288	189	5	to	to	PART
cusj-10288	189	6	exert	exert	VERB
cusj-10288	189	7	antichorea	antichorea	NOUN
cusj-10288	189	8	effects	effect	NOUN
cusj-10288	189	9	in	in	ADP
cusj-10288	189	10	patients	patient	NOUN
cusj-10288	189	11	with	with	ADP
cusj-10288	189	12	hd	hd	NOUN
cusj-10288	189	13	and	and	CCONJ
cusj-10288	189	14	was	be	AUX
cusj-10288	189	15	the	the	DET
cusj-10288	189	16	first	first	ADJ
cusj-10288	189	17	approved	approve	VERB
cusj-10288	189	18	drug	drug	NOUN
cusj-10288	189	19	for	for	ADP
cusj-10288	189	20	the	the	DET
cusj-10288	189	21	disease	disease	NOUN
cusj-10288	189	22	[	[	X
cusj-10288	189	23	78	78	NUM
cusj-10288	189	24	]	]	PUNCT
cusj-10288	189	25	.	.	PUNCT
cusj-10288	190	1	however	however	ADV
cusj-10288	190	2	,	,	PUNCT
cusj-10288	190	3	tbz	tbz	PROPN
cusj-10288	190	4	has	have	VERB
cusj-10288	190	5	some	some	DET
cusj-10288	190	6	limitations	limitation	NOUN
cusj-10288	190	7	,	,	PUNCT
cusj-10288	190	8	such	such	ADJ
cusj-10288	190	9	as	as	ADP
cusj-10288	190	10	low	low	ADJ
cusj-10288	190	11	bioavailability	bioavailability	NOUN
cusj-10288	190	12	and	and	CCONJ
cusj-10288	190	13	adverse	adverse	ADJ
cusj-10288	190	14	effects	effect	NOUN
cusj-10288	190	15	.	.	PUNCT
cusj-10288	191	1	therefore	therefore	ADV
cusj-10288	191	2	,	,	PUNCT
cusj-10288	191	3	studies	study	NOUN
cusj-10288	191	4	have	have	AUX
cusj-10288	191	5	been	be	AUX
cusj-10288	191	6	conducted	conduct	VERB
cusj-10288	191	7	to	to	PART
cusj-10288	191	8	optimize	optimize	VERB
cusj-10288	191	9	the	the	DET
cusj-10288	191	10	drug	drug	NOUN
cusj-10288	191	11	delivery	delivery	NOUN
cusj-10288	191	12	and	and	CCONJ
cusj-10288	191	13	bioavailability	bioavailability	NOUN
cusj-10288	191	14	of	of	ADP
cusj-10288	191	15	tbz	tbz	PRON
cusj-10288	191	16	using	use	VERB
cusj-10288	191	17	nanotechnology	nanotechnology	NOUN
cusj-10288	191	18	techniques	technique	NOUN
cusj-10288	191	19	,	,	PUNCT
cusj-10288	191	20	such	such	ADJ
cusj-10288	191	21	as	as	ADP
cusj-10288	191	22	nanoparticles	nanoparticle	NOUN
cusj-10288	191	23	and	and	CCONJ
cusj-10288	191	24	nanocapsules	nanocapsule	NOUN
cusj-10288	191	25	[	[	X
cusj-10288	191	26	79	79	NUM
cusj-10288	191	27	]	]	PUNCT
cusj-10288	191	28	.	.	PUNCT
cusj-10288	192	1	another	another	DET
cusj-10288	192	2	class	class	NOUN
cusj-10288	192	3	of	of	ADP
cusj-10288	192	4	compounds	compound	NOUN
cusj-10288	192	5	that	that	PRON
cusj-10288	192	6	may	may	AUX
cusj-10288	192	7	have	have	VERB
cusj-10288	192	8	beneficial	beneficial	ADJ
cusj-10288	192	9	effects	effect	NOUN
cusj-10288	192	10	for	for	ADP
cusj-10288	192	11	hd	hd	NOUN
cusj-10288	192	12	are	be	AUX
cusj-10288	192	13	flavonoids	flavonoid	NOUN
cusj-10288	192	14	,	,	PUNCT
cusj-10288	192	15	which	which	PRON
cusj-10288	192	16	are	be	AUX
cusj-10288	192	17	natural	natural	ADJ
cusj-10288	192	18	polyphenolic	polyphenolic	ADJ
cusj-10288	192	19	compounds	compound	NOUN
cusj-10288	192	20	found	find	VERB
cusj-10288	192	21	in	in	ADP
cusj-10288	192	22	plants	plant	NOUN
cusj-10288	192	23	.	.	PUNCT
cusj-10288	193	1	flavonoids	flavonoid	NOUN
cusj-10288	193	2	have	have	AUX
cusj-10288	193	3	been	be	AUX
cusj-10288	193	4	shown	show	VERB
cusj-10288	193	5	to	to	PART
cusj-10288	193	6	reduce	reduce	VERB
cusj-10288	193	7	cellular	cellular	ADJ
cusj-10288	193	8	stress	stress	NOUN
cusj-10288	193	9	and	and	CCONJ
cusj-10288	193	10	exert	exert	VERB
cusj-10288	193	11	anti	anti	ADJ
cusj-10288	193	12	-	-	ADJ
cusj-10288	193	13	inflammatory	inflammatory	ADJ
cusj-10288	193	14	and	and	CCONJ
cusj-10288	193	15	antiapoptotic	antiapoptotic	ADJ
cusj-10288	193	16	effects	effect	NOUN
cusj-10288	193	17	in	in	ADP
cusj-10288	193	18	the	the	DET
cusj-10288	193	19	cell	cell	NOUN
cusj-10288	193	20	[	[	X
cusj-10288	193	21	80	80	NUM
cusj-10288	193	22	]	]	PUNCT
cusj-10288	193	23	.	.	PUNCT
cusj-10288	194	1	some	some	DET
cusj-10288	194	2	examples	example	NOUN
cusj-10288	194	3	of	of	ADP
cusj-10288	194	4	flavonoids	flavonoid	NOUN
cusj-10288	194	5	that	that	PRON
cusj-10288	194	6	have	have	AUX
cusj-10288	194	7	been	be	AUX
cusj-10288	194	8	tested	test	VERB
cusj-10288	194	9	for	for	ADP
cusj-10288	194	10	hd	hd	NOUN
cusj-10288	194	11	are	be	AUX
cusj-10288	194	12	resveratrol	resveratrol	NOUN
cusj-10288	194	13	,	,	PUNCT
cusj-10288	194	14	curcumin	curcumin	NOUN
cusj-10288	194	15	,	,	PUNCT
cusj-10288	194	16	and	and	CCONJ
cusj-10288	194	17	quercetin	quercetin	NOUN
cusj-10288	194	18	.	.	PUNCT
cusj-10288	195	1	marine	marine	PROPN
cusj-10288	195	2	compounds	compound	NOUN
cusj-10288	195	3	have	have	AUX
cusj-10288	195	4	been	be	AUX
cusj-10288	195	5	proposed	propose	VERB
cusj-10288	195	6	as	as	ADP
cusj-10288	195	7	potential	potential	ADJ
cusj-10288	195	8	sources	source	NOUN
cusj-10288	195	9	of	of	ADP
cusj-10288	195	10	novel	novel	ADJ
cusj-10288	195	11	drugs	drug	NOUN
cusj-10288	195	12	for	for	ADP
cusj-10288	195	13	hd	hd	NOUN
cusj-10288	195	14	and	and	CCONJ
cusj-10288	195	15	other	other	ADJ
cusj-10288	195	16	neurodegenerative	neurodegenerative	ADJ
cusj-10288	195	17	diseases	disease	NOUN
cusj-10288	195	18	.	.	PUNCT
cusj-10288	196	1	marine	marine	PROPN
cusj-10288	196	2	compounds	compound	NOUN
cusj-10288	196	3	have	have	VERB
cusj-10288	196	4	diverse	diverse	ADJ
cusj-10288	196	5	chemical	chemical	NOUN
cusj-10288	196	6	structures	structure	NOUN
cusj-10288	196	7	and	and	CCONJ
cusj-10288	196	8	biological	biological	ADJ
cusj-10288	196	9	activities	activity	NOUN
cusj-10288	196	10	,	,	PUNCT
cusj-10288	196	11	such	such	ADJ
cusj-10288	196	12	as	as	ADP
cusj-10288	196	13	antioxidant	antioxidant	ADJ
cusj-10288	196	14	,	,	PUNCT
cusj-10288	196	15	anti	anti	ADJ
cusj-10288	196	16	-	-	ADJ
cusj-10288	196	17	inflammatory	inflammatory	ADJ
cusj-10288	196	18	,	,	PUNCT
cusj-10288	196	19	and	and	CCONJ
cusj-10288	196	20	anti	anti	ADJ
cusj-10288	196	21	-	-	ADJ
cusj-10288	196	22	apoptotic	apoptotic	ADJ
cusj-10288	196	23	properties	property	NOUN
cusj-10288	196	24	.	.	PUNCT
cusj-10288	197	1	some	some	DET
cusj-10288	197	2	examples	example	NOUN
cusj-10288	197	3	of	of	ADP
cusj-10288	197	4	marine	marine	ADJ
cusj-10288	197	5	compounds	compound	NOUN
cusj-10288	197	6	that	that	PRON
cusj-10288	197	7	have	have	AUX
cusj-10288	197	8	been	be	AUX
cusj-10288	197	9	investigated	investigate	VERB
cusj-10288	197	10	for	for	ADP
cusj-10288	197	11	hd	hd	NOUN
cusj-10288	197	12	are	be	AUX
cusj-10288	197	13	fucoidan	fucoidan	ADJ
cusj-10288	197	14	,	,	PUNCT
cusj-10288	197	15	xyloketal	xyloketal	ADJ
cusj-10288	197	16	b	b	NOUN
cusj-10288	197	17	,	,	PUNCT
cusj-10288	197	18	fucoxanthin	fucoxanthin	NOUN
cusj-10288	197	19	,	,	PUNCT
cusj-10288	197	20	and	and	CCONJ
cusj-10288	197	21	cerebrosides	cerebroside	VERB
cusj-10288	197	22	[	[	PUNCT
cusj-10288	197	23	67	67	NUM
cusj-10288	197	24	,	,	PUNCT
cusj-10288	197	25	81	81	NUM
cusj-10288	197	26	]	]	PUNCT
cusj-10288	197	27	.	.	PUNCT
cusj-10288	198	1	a	a	DET
cusj-10288	198	2	recent	recent	ADJ
cusj-10288	198	3	study	study	NOUN
cusj-10288	198	4	suggested	suggest	VERB
cusj-10288	198	5	that	that	SCONJ
cusj-10288	198	6	pridopidine	pridopidine	NOUN
cusj-10288	198	7	,	,	PUNCT
cusj-10288	198	8	a	a	DET
cusj-10288	198	9	dopamine	dopamine	NOUN
cusj-10288	198	10	stabilizer	stabilizer	NOUN
cusj-10288	198	11	,	,	PUNCT
cusj-10288	198	12	may	may	AUX
cusj-10288	198	13	be	be	AUX
cusj-10288	198	14	a	a	DET
cusj-10288	198	15	promising	promising	ADJ
cusj-10288	198	16	drug	drug	NOUN
cusj-10288	198	17	for	for	ADP
cusj-10288	198	18	hd	hd	NOUN
cusj-10288	198	19	symptoms	symptom	NOUN
cusj-10288	198	20	.	.	PUNCT
cusj-10288	199	1	pridopidine	pridopidine	NOUN
cusj-10288	199	2	acts	act	NOUN
cusj-10288	199	3	on	on	ADP
cusj-10288	199	4	the	the	DET
cusj-10288	199	5	sigma-1	sigma-1	NUM
cusj-10288	199	6	receptor	receptor	NOUN
cusj-10288	199	7	,	,	PUNCT
cusj-10288	199	8	which	which	PRON
cusj-10288	199	9	is	be	AUX
cusj-10288	199	10	involved	involve	VERB
cusj-10288	199	11	in	in	ADP
cusj-10288	199	12	the	the	DET
cusj-10288	199	13	regulation	regulation	NOUN
cusj-10288	199	14	of	of	ADP
cusj-10288	199	15	calcium	calcium	NOUN
cusj-10288	199	16	homeostasis	homeostasis	NOUN
cusj-10288	199	17	,	,	PUNCT
cusj-10288	199	18	mitochondrial	mitochondrial	ADJ
cusj-10288	199	19	function	function	NOUN
cusj-10288	199	20	,	,	PUNCT
cusj-10288	199	21	and	and	CCONJ
cusj-10288	199	22	neuroprotection	neuroprotection	NOUN
cusj-10288	199	23	.	.	PUNCT
cusj-10288	200	1	pridopidine	pridopidine	NOUN
cusj-10288	200	2	has	have	AUX
cusj-10288	200	3	been	be	AUX
cusj-10288	200	4	shown	show	VERB
cusj-10288	200	5	to	to	PART
cusj-10288	200	6	improve	improve	VERB
cusj-10288	200	7	motor	motor	NOUN
cusj-10288	200	8	and	and	CCONJ
cusj-10288	200	9	cognitive	cognitive	ADJ
cusj-10288	200	10	functions	function	NOUN
cusj-10288	200	11	in	in	ADP
cusj-10288	200	12	hd	hd	NOUN
cusj-10288	200	13	animal	animal	NOUN
cusj-10288	200	14	models	model	NOUN
cusj-10288	200	15	and	and	CCONJ
cusj-10288	200	16	patients	patient	NOUN
cusj-10288	200	17	[	[	X
cusj-10288	200	18	82	82	NUM
cusj-10288	200	19	]	]	PUNCT
cusj-10288	200	20	.	.	PUNCT
cusj-10288	201	1	the	the	DET
cusj-10288	201	2	stage	stage	NOUN
cusj-10288	201	3	of	of	ADP
cusj-10288	201	4	huntington	huntington	PROPN
cusj-10288	201	5	's	's	PART
cusj-10288	201	6	disease	disease	NOUN
cusj-10288	201	7	(	(	PUNCT
cusj-10288	201	8	hd	hd	NOUN
cusj-10288	201	9	)	)	PUNCT
cusj-10288	201	10	is	be	AUX
cusj-10288	201	11	related	relate	VERB
cusj-10288	201	12	to	to	ADP
cusj-10288	201	13	the	the	DET
cusj-10288	201	14	amount	amount	NOUN
cusj-10288	201	15	of	of	ADP
cusj-10288	201	16	dopamine	dopamine	NOUN
cusj-10288	201	17	in	in	ADP
cusj-10288	201	18	the	the	DET
cusj-10288	201	19	central	central	ADJ
cusj-10288	201	20	nervous	nervous	ADJ
cusj-10288	201	21	system	system	NOUN
cusj-10288	201	22	,	,	PUNCT
cusj-10288	201	23	since	since	SCONJ
cusj-10288	201	24	dopaminergic	dopaminergic	ADJ
cusj-10288	201	25	conduction	conduction	NOUN
cusj-10288	201	26	disorders	disorder	NOUN
cusj-10288	201	27	are	be	AUX
cusj-10288	201	28	the	the	DET
cusj-10288	201	29	main	main	ADJ
cusj-10288	201	30	cause	cause	NOUN
cusj-10288	201	31	of	of	ADP
cusj-10288	201	32	hd	hd	PROPN
cusj-10288	201	33	.	.	PUNCT
cusj-10288	201	34	pridopidine	pridopidine	NOUN
cusj-10288	201	35	,	,	PUNCT
cusj-10288	201	36	a	a	DET
cusj-10288	201	37	drug	drug	NOUN
cusj-10288	201	38	that	that	PRON
cusj-10288	201	39	protects	protect	VERB
cusj-10288	201	40	nerve	nerve	NOUN
cusj-10288	201	41	cells	cell	NOUN
cusj-10288	201	42	from	from	ADP
cusj-10288	201	43	degeneration	degeneration	NOUN
cusj-10288	201	44	,	,	PUNCT
cusj-10288	201	45	has	have	AUX
cusj-10288	201	46	shown	show	VERB
cusj-10288	201	47	promising	promising	ADJ
cusj-10288	201	48	results	result	NOUN
cusj-10288	201	49	in	in	ADP
cusj-10288	201	50	animal	animal	NOUN
cusj-10288	201	51	models	model	NOUN
cusj-10288	201	52	[	[	X
cusj-10288	201	53	83	83	NUM
cusj-10288	201	54	]	]	PUNCT
cusj-10288	201	55	.	.	PUNCT
cusj-10288	202	1	drug	drug	NOUN
cusj-10288	202	2	treatment	treatment	NOUN
cusj-10288	202	3	for	for	ADP
cusj-10288	202	4	hd	hd	NOUN
cusj-10288	202	5	has	have	VERB
cusj-10288	202	6	the	the	DET
cusj-10288	202	7	advantage	advantage	NOUN
cusj-10288	202	8	of	of	ADP
cusj-10288	202	9	being	be	AUX
cusj-10288	202	10	based	base	VERB
cusj-10288	202	11	on	on	ADP
cusj-10288	202	12	well	well	ADV
cusj-10288	202	13	-	-	PUNCT
cusj-10288	202	14	studied	study	VERB
cusj-10288	202	15	active	active	ADJ
cusj-10288	202	16	compounds	compound	NOUN
cusj-10288	202	17	that	that	PRON
cusj-10288	202	18	are	be	AUX
cusj-10288	202	19	effective	effective	ADJ
cusj-10288	202	20	and	and	CCONJ
cusj-10288	202	21	tolerable	tolerable	ADJ
cusj-10288	202	22	for	for	ADP
cusj-10288	202	23	other	other	ADJ
cusj-10288	202	24	similar	similar	ADJ
cusj-10288	202	25	neurodegenerative	neurodegenerative	ADJ
cusj-10288	202	26	diseases	disease	NOUN
cusj-10288	202	27	[	[	X
cusj-10288	202	28	67	67	NUM
cusj-10288	202	29	]	]	PUNCT
cusj-10288	202	30	.	.	PUNCT
cusj-10288	203	1	this	this	PRON
cusj-10288	203	2	makes	make	VERB
cusj-10288	203	3	it	it	PRON
cusj-10288	203	4	easier	easy	ADJ
cusj-10288	203	5	to	to	PART
cusj-10288	203	6	personalize	personalize	VERB
cusj-10288	203	7	the	the	DET
cusj-10288	203	8	medication	medication	NOUN
cusj-10288	203	9	according	accord	VERB
cusj-10288	203	10	to	to	ADP
cusj-10288	203	11	the	the	DET
cusj-10288	203	12	patient	patient	NOUN
cusj-10288	203	13	's	's	PART
cusj-10288	203	14	diagnostics	diagnostic	NOUN
cusj-10288	203	15	.	.	PUNCT
cusj-10288	204	1	another	another	DET
cusj-10288	204	2	potential	potential	ADJ
cusj-10288	204	3	treatment	treatment	NOUN
cusj-10288	204	4	for	for	ADP
cusj-10288	204	5	hd	hd	NOUN
cusj-10288	204	6	is	be	AUX
cusj-10288	204	7	cell	cell	NOUN
cusj-10288	204	8	replacement	replacement	NOUN
cusj-10288	204	9	therapy	therapy	NOUN
cusj-10288	204	10	using	use	VERB
cusj-10288	204	11	stem	stem	NOUN
cusj-10288	204	12	cells	cell	NOUN
cusj-10288	204	13	,	,	PUNCT
cusj-10288	204	14	which	which	PRON
cusj-10288	204	15	could	could	AUX
cusj-10288	204	16	reduce	reduce	VERB
cusj-10288	204	17	the	the	DET
cusj-10288	204	18	symptoms	symptom	NOUN
cusj-10288	204	19	of	of	ADP
cusj-10288	204	20	the	the	DET
cusj-10288	204	21	disease	disease	NOUN
cusj-10288	204	22	[	[	X
cusj-10288	204	23	84	84	NUM
cusj-10288	204	24	]	]	PUNCT
cusj-10288	204	25	.	.	PUNCT
cusj-10288	205	1	moreover	moreover	ADV
cusj-10288	205	2	,	,	PUNCT
cusj-10288	205	3	exercise	exercise	NOUN
cusj-10288	205	4	and	and	CCONJ
cusj-10288	205	5	physical	physical	ADJ
cusj-10288	205	6	activity	activity	NOUN
cusj-10288	205	7	columbia	columbia	PROPN
cusj-10288	205	8	undergraduate	undergraduate	PROPN
cusj-10288	205	9	science	science	PROPN
cusj-10288	205	10	journal	journal	PROPN
cusj-10288	205	11	vol	vol	NOUN
cusj-10288	205	12	.	.	PROPN
cusj-10288	205	13	17	17	NUM
cusj-10288	205	14	,	,	PUNCT
cusj-10288	205	15	2023	2023	NUM
cusj-10288	205	16	datta	datta	NOUN
cusj-10288	205	17	25	25	NUM
cusj-10288	205	18	have	have	AUX
cusj-10288	205	19	been	be	AUX
cusj-10288	205	20	reported	report	VERB
cusj-10288	205	21	to	to	PART
cusj-10288	205	22	have	have	VERB
cusj-10288	205	23	positive	positive	ADJ
cusj-10288	205	24	effects	effect	NOUN
cusj-10288	205	25	on	on	ADP
cusj-10288	205	26	the	the	DET
cusj-10288	205	27	motor	motor	NOUN
cusj-10288	205	28	function	function	NOUN
cusj-10288	205	29	,	,	PUNCT
cusj-10288	205	30	gait	gait	ADJ
cusj-10288	205	31	speed	speed	NOUN
cusj-10288	205	32	,	,	PUNCT
cusj-10288	205	33	balance	balance	NOUN
cusj-10288	205	34	,	,	PUNCT
cusj-10288	205	35	and	and	CCONJ
cusj-10288	205	36	social	social	ADJ
cusj-10288	205	37	well	well	ADV
cusj-10288	205	38	-	-	PUNCT
cusj-10288	205	39	being	being	NOUN
cusj-10288	205	40	of	of	ADP
cusj-10288	205	41	hd	hd	NOUN
cusj-10288	205	42	patients	patient	NOUN
cusj-10288	205	43	[	[	X
cusj-10288	205	44	67	67	NUM
cusj-10288	205	45	,	,	PUNCT
cusj-10288	205	46	85	85	NUM
cusj-10288	205	47	]	]	PUNCT
cusj-10288	205	48	.	.	PUNCT
cusj-10288	206	1	therefore	therefore	ADV
cusj-10288	206	2	,	,	PUNCT
cusj-10288	206	3	exercise	exercise	NOUN
cusj-10288	206	4	could	could	AUX
cusj-10288	206	5	be	be	AUX
cusj-10288	206	6	a	a	DET
cusj-10288	206	7	complementary	complementary	ADJ
cusj-10288	206	8	therapy	therapy	NOUN
cusj-10288	206	9	for	for	ADP
cusj-10288	206	10	hd	hd	PROPN
cusj-10288	206	11	.	.	PUNCT
cusj-10288	207	1	a	a	DET
cusj-10288	207	2	novel	novel	ADJ
cusj-10288	207	3	approach	approach	NOUN
cusj-10288	207	4	to	to	PART
cusj-10288	207	5	target	target	VERB
cusj-10288	207	6	the	the	DET
cusj-10288	207	7	underlying	underlie	VERB
cusj-10288	207	8	cause	cause	NOUN
cusj-10288	207	9	of	of	ADP
cusj-10288	207	10	hd	hd	NOUN
cusj-10288	207	11	is	be	AUX
cusj-10288	207	12	the	the	DET
cusj-10288	207	13	use	use	NOUN
cusj-10288	207	14	of	of	ADP
cusj-10288	207	15	monoclonal	monoclonal	NOUN
cusj-10288	207	16	antibodies	antibody	NOUN
cusj-10288	207	17	that	that	PRON
cusj-10288	207	18	bind	bind	VERB
cusj-10288	207	19	to	to	ADP
cusj-10288	207	20	the	the	DET
cusj-10288	207	21	mutant	mutant	ADJ
cusj-10288	207	22	huntingtin	huntingtin	NOUN
cusj-10288	207	23	(	(	PUNCT
cusj-10288	207	24	mhtt	mhtt	NOUN
cusj-10288	207	25	)	)	PUNCT
cusj-10288	207	26	protein	protein	NOUN
cusj-10288	207	27	and	and	CCONJ
cusj-10288	207	28	lower	lower	VERB
cusj-10288	207	29	its	its	PRON
cusj-10288	207	30	concentration	concentration	NOUN
cusj-10288	207	31	in	in	ADP
cusj-10288	207	32	the	the	DET
cusj-10288	207	33	cell	cell	NOUN
cusj-10288	207	34	.	.	PUNCT
cusj-10288	208	1	this	this	PRON
cusj-10288	208	2	could	could	AUX
cusj-10288	208	3	prevent	prevent	VERB
cusj-10288	208	4	the	the	DET
cusj-10288	208	5	mhtt	mhtt	NOUN
cusj-10288	208	6	from	from	ADP
cusj-10288	208	7	spreading	spread	VERB
cusj-10288	208	8	and	and	CCONJ
cusj-10288	208	9	causing	cause	VERB
cusj-10288	208	10	damage	damage	NOUN
cusj-10288	208	11	to	to	ADP
cusj-10288	208	12	the	the	DET
cusj-10288	208	13	brain	brain	NOUN
cusj-10288	208	14	[	[	X
cusj-10288	208	15	84	84	NUM
cusj-10288	208	16	]	]	PUNCT
cusj-10288	208	17	.	.	PUNCT
cusj-10288	209	1	gene	gene	NOUN
cusj-10288	209	2	therapy	therapy	NOUN
cusj-10288	209	3	:	:	PUNCT
cusj-10288	209	4	a	a	DET
cusj-10288	209	5	possible	possible	ADJ
cusj-10288	209	6	treatment	treatment	NOUN
cusj-10288	209	7	of	of	ADP
cusj-10288	209	8	hd	hd	NOUN
cusj-10288	209	9	in	in	ADP
cusj-10288	209	10	the	the	DET
cusj-10288	209	11	future	future	ADJ
cusj-10288	209	12	research	research	NOUN
cusj-10288	209	13	into	into	ADP
cusj-10288	209	14	gene	gene	NOUN
cusj-10288	209	15	therapy	therapy	NOUN
cusj-10288	209	16	has	have	AUX
cusj-10288	209	17	led	lead	VERB
cusj-10288	209	18	to	to	ADP
cusj-10288	209	19	the	the	DET
cusj-10288	209	20	most	most	ADV
cusj-10288	209	21	exhilarating	exhilarating	ADJ
cusj-10288	209	22	and	and	CCONJ
cusj-10288	209	23	favorable	favorable	ADJ
cusj-10288	209	24	advances	advance	NOUN
cusj-10288	209	25	in	in	ADP
cusj-10288	209	26	hd	hd	NOUN
cusj-10288	209	27	research	research	NOUN
cusj-10288	209	28	.	.	PUNCT
cusj-10288	210	1	a	a	DET
cusj-10288	210	2	potential	potential	ADJ
cusj-10288	210	3	therapy	therapy	NOUN
cusj-10288	210	4	for	for	ADP
cusj-10288	210	5	dominant	dominant	ADJ
cusj-10288	210	6	genetic	genetic	ADJ
cusj-10288	210	7	disorders	disorder	NOUN
cusj-10288	210	8	,	,	PUNCT
cusj-10288	210	9	silencing	silence	VERB
cusj-10288	210	10	mutant	mutant	ADJ
cusj-10288	210	11	genes	gene	NOUN
cusj-10288	210	12	can	can	AUX
cusj-10288	210	13	offer	offer	VERB
cusj-10288	210	14	major	major	ADJ
cusj-10288	210	15	benefits	benefit	NOUN
cusj-10288	210	16	.	.	PUNCT
cusj-10288	211	1	it	it	PRON
cusj-10288	211	2	is	be	AUX
cusj-10288	211	3	generally	generally	ADV
cusj-10288	211	4	believed	believe	VERB
cusj-10288	211	5	that	that	SCONJ
cusj-10288	211	6	gene	gene	NOUN
cusj-10288	211	7	therapy	therapy	NOUN
cusj-10288	211	8	could	could	AUX
cusj-10288	211	9	have	have	VERB
cusj-10288	211	10	a	a	DET
cusj-10288	211	11	twofold	twofold	ADJ
cusj-10288	211	12	effect	effect	NOUN
cusj-10288	211	13	:	:	PUNCT
cusj-10288	211	14	(	(	PUNCT
cusj-10288	211	15	i	i	NOUN
cusj-10288	211	16	)	)	PUNCT
cusj-10288	211	17	restoring	restore	VERB
cusj-10288	211	18	function	function	NOUN
cusj-10288	211	19	to	to	ADP
cusj-10288	211	20	non	non	ADJ
cusj-10288	211	21	-	-	ADJ
cusj-10288	211	22	dead	dead	ADJ
cusj-10288	211	23	,	,	PUNCT
cusj-10288	211	24	but	but	CCONJ
cusj-10288	211	25	dysfunctional	dysfunctional	ADJ
cusj-10288	211	26	neuronal	neuronal	ADJ
cusj-10288	211	27	circuits	circuit	NOUN
cusj-10288	211	28	,	,	PUNCT
cusj-10288	211	29	and	and	CCONJ
cusj-10288	211	30	(	(	PUNCT
cusj-10288	211	31	ii	ii	NOUN
cusj-10288	211	32	)	)	PUNCT
cusj-10288	211	33	protecting	protect	VERB
cusj-10288	211	34	against	against	ADP
cusj-10288	211	35	disease	disease	NOUN
cusj-10288	211	36	progression	progression	NOUN
cusj-10288	211	37	[	[	X
cusj-10288	211	38	86	86	NUM
cusj-10288	211	39	]	]	PUNCT
cusj-10288	211	40	.	.	PUNCT
cusj-10288	212	1	as	as	ADP
cusj-10288	212	2	a	a	DET
cusj-10288	212	3	matter	matter	NOUN
cusj-10288	212	4	of	of	ADP
cusj-10288	212	5	fact	fact	NOUN
cusj-10288	212	6	,	,	PUNCT
cusj-10288	212	7	gene	gene	NOUN
cusj-10288	212	8	therapy	therapy	NOUN
cusj-10288	212	9	will	will	AUX
cusj-10288	212	10	not	not	PART
cusj-10288	212	11	be	be	AUX
cusj-10288	212	12	used	use	VERB
cusj-10288	212	13	to	to	PART
cusj-10288	212	14	treat	treat	VERB
cusj-10288	212	15	disease	disease	NOUN
cusj-10288	212	16	,	,	PUNCT
cusj-10288	212	17	but	but	CCONJ
cusj-10288	212	18	to	to	PART
cusj-10288	212	19	prevent	prevent	VERB
cusj-10288	212	20	it	it	PRON
cusj-10288	212	21	to	to	PART
cusj-10288	212	22	eliminate	eliminate	VERB
cusj-10288	212	23	symptoms	symptom	NOUN
cusj-10288	212	24	entirely	entirely	ADV
cusj-10288	212	25	.	.	PUNCT
cusj-10288	213	1	molecular	molecular	ADJ
cusj-10288	213	2	gene	gene	NOUN
cusj-10288	213	3	therapy	therapy	NOUN
cusj-10288	213	4	targets	target	VERB
cusj-10288	213	5	the	the	DET
cusj-10288	213	6	transcription	transcription	NOUN
cusj-10288	213	7	and	and	CCONJ
cusj-10288	213	8	translation	translation	NOUN
cusj-10288	213	9	processes	process	NOUN
cusj-10288	213	10	of	of	ADP
cusj-10288	213	11	dna	dna	NOUN
cusj-10288	213	12	into	into	ADP
cusj-10288	213	13	mrna	mrna	PROPN
cusj-10288	213	14	(	(	PUNCT
cusj-10288	213	15	messenger	messenger	PROPN
cusj-10288	213	16	rna	rna	PROPN
cusj-10288	213	17	)	)	PUNCT
cusj-10288	213	18	by	by	ADP
cusj-10288	213	19	a	a	DET
cusj-10288	213	20	process	process	NOUN
cusj-10288	213	21	called	call	VERB
cusj-10288	213	22	transcription	transcription	NOUN
cusj-10288	213	23	and	and	CCONJ
cusj-10288	213	24	the	the	DET
cusj-10288	213	25	synthesis	synthesis	NOUN
cusj-10288	213	26	of	of	ADP
cusj-10288	213	27	proteins	protein	NOUN
cusj-10288	213	28	using	use	VERB
cusj-10288	213	29	the	the	DET
cusj-10288	213	30	information	information	NOUN
cusj-10288	213	31	in	in	ADP
cusj-10288	213	32	mrna	mrna	PROPN
cusj-10288	213	33	(	(	PUNCT
cusj-10288	213	34	a	a	DET
cusj-10288	213	35	process	process	NOUN
cusj-10288	213	36	called	call	VERB
cusj-10288	213	37	translation	translation	NOUN
cusj-10288	213	38	)	)	PUNCT
cusj-10288	214	1	[	[	X
cusj-10288	214	2	87	87	NUM
cusj-10288	214	3	]	]	PUNCT
cusj-10288	214	4	.	.	PUNCT
cusj-10288	215	1	antisense	antisense	NOUN
cusj-10288	215	2	oligonucleotides	oligonucleotide	NOUN
cusj-10288	215	3	(	(	PUNCT
cusj-10288	215	4	asos	asos	NOUN
cusj-10288	215	5	)	)	PUNCT
cusj-10288	215	6	,	,	PUNCT
cusj-10288	215	7	zinc	zinc	NOUN
cusj-10288	215	8	finger	finger	NOUN
cusj-10288	215	9	proteins	protein	NOUN
cusj-10288	215	10	,	,	PUNCT
cusj-10288	215	11	and	and	CCONJ
cusj-10288	215	12	rna	rna	NOUN
cusj-10288	215	13	interference	interference	NOUN
cusj-10288	215	14	techniques	technique	NOUN
cusj-10288	215	15	are	be	AUX
cusj-10288	215	16	three	three	NUM
cusj-10288	215	17	common	common	ADJ
cusj-10288	215	18	methods	method	NOUN
cusj-10288	215	19	for	for	ADP
cusj-10288	215	20	gene	gene	NOUN
cusj-10288	215	21	-	-	PUNCT
cusj-10288	215	22	silencing	silence	VERB
cusj-10288	215	23	[	[	NOUN
cusj-10288	215	24	88	88	NUM
cusj-10288	215	25	]	]	PUNCT
cusj-10288	215	26	.	.	PUNCT
cusj-10288	216	1	zinc	zinc	NOUN
cusj-10288	216	2	finger	finger	NOUN
cusj-10288	216	3	proteins	protein	NOUN
cusj-10288	216	4	suppress	suppress	VERB
cusj-10288	216	5	transcription	transcription	NOUN
cusj-10288	216	6	,	,	PUNCT
cusj-10288	216	7	antisense	antisense	NOUN
cusj-10288	216	8	oligonucleotides	oligonucleotide	NOUN
cusj-10288	216	9	suppress	suppress	VERB
cusj-10288	216	10	translation	translation	NOUN
cusj-10288	216	11	of	of	ADP
cusj-10288	216	12	mhtt	mhtt	NOUN
cusj-10288	216	13	,	,	PUNCT
cusj-10288	216	14	and	and	CCONJ
cusj-10288	216	15	rna	rna	NOUN
cusj-10288	216	16	interference	interference	NOUN
cusj-10288	216	17	blocks	block	VERB
cusj-10288	216	18	protein	protein	NOUN
cusj-10288	216	19	translation	translation	NOUN
cusj-10288	216	20	[	[	X
cusj-10288	216	21	89	89	NUM
cusj-10288	216	22	]	]	PUNCT
cusj-10288	216	23	in	in	ADP
cusj-10288	216	24	large	large	ADJ
cusj-10288	216	25	neuroimaging	neuroimage	VERB
cusj-10288	216	26	studies	study	NOUN
cusj-10288	216	27	performed	perform	VERB
cusj-10288	216	28	during	during	ADP
cusj-10288	216	29	prehd	prehd	NOUN
cusj-10288	216	30	,	,	PUNCT
cusj-10288	216	31	measurable	measurable	ADJ
cusj-10288	216	32	measures	measure	NOUN
cusj-10288	216	33	of	of	ADP
cusj-10288	216	34	brain	brain	NOUN
cusj-10288	216	35	regions	region	NOUN
cusj-10288	216	36	such	such	ADJ
cusj-10288	216	37	as	as	ADP
cusj-10288	216	38	the	the	DET
cusj-10288	216	39	striatum	striatum	NOUN
cusj-10288	216	40	have	have	AUX
cusj-10288	216	41	been	be	AUX
cusj-10288	216	42	found	find	VERB
cusj-10288	216	43	to	to	PART
cusj-10288	216	44	be	be	AUX
cusj-10288	216	45	excellent	excellent	ADJ
cusj-10288	216	46	biomarkers	biomarker	NOUN
cusj-10288	216	47	of	of	ADP
cusj-10288	216	48	disease	disease	NOUN
cusj-10288	216	49	progression	progression	NOUN
cusj-10288	216	50	and	and	CCONJ
cusj-10288	216	51	will	will	AUX
cusj-10288	216	52	be	be	AUX
cusj-10288	216	53	useful	useful	ADJ
cusj-10288	216	54	in	in	ADP
cusj-10288	216	55	future	future	ADJ
cusj-10288	216	56	gene	gene	NOUN
cusj-10288	216	57	therapy	therapy	NOUN
cusj-10288	216	58	trials	trial	NOUN
cusj-10288	216	59	[	[	X
cusj-10288	216	60	90	90	NUM
cusj-10288	216	61	]	]	PUNCT
cusj-10288	216	62	.	.	PUNCT
cusj-10288	217	1	conclusion	conclusion	NOUN
cusj-10288	217	2	research	research	NOUN
cusj-10288	217	3	indicates	indicate	VERB
cusj-10288	217	4	that	that	SCONJ
cusj-10288	217	5	the	the	DET
cusj-10288	217	6	pathology	pathology	NOUN
cusj-10288	217	7	of	of	ADP
cusj-10288	217	8	huntington	huntington	PROPN
cusj-10288	217	9	's	's	PART
cusj-10288	217	10	disease	disease	NOUN
cusj-10288	217	11	(	(	PUNCT
cusj-10288	217	12	hd	hd	NOUN
cusj-10288	217	13	)	)	PUNCT
cusj-10288	217	14	may	may	AUX
cusj-10288	217	15	be	be	AUX
cusj-10288	217	16	significantly	significantly	ADV
cusj-10288	217	17	influenced	influence	VERB
cusj-10288	217	18	by	by	ADP
cusj-10288	217	19	the	the	DET
cusj-10288	217	20	loss	loss	NOUN
cusj-10288	217	21	of	of	ADP
cusj-10288	217	22	function	function	NOUN
cusj-10288	217	23	in	in	ADP
cusj-10288	217	24	the	the	DET
cusj-10288	217	25	normal	normal	ADJ
cusj-10288	217	26	htt	htt	NOUN
cusj-10288	217	27	protein	protein	NOUN
cusj-10288	217	28	,	,	PUNCT
cusj-10288	217	29	despite	despite	SCONJ
cusj-10288	217	30	the	the	DET
cusj-10288	217	31	disease	disease	NOUN
cusj-10288	217	32	primarily	primarily	ADV
cusj-10288	217	33	being	be	AUX
cusj-10288	217	34	attributed	attribute	VERB
cusj-10288	217	35	to	to	ADP
cusj-10288	217	36	a	a	DET
cusj-10288	217	37	toxic	toxic	ADJ
cusj-10288	217	38	gain	gain	NOUN
cusj-10288	217	39	of	of	ADP
cusj-10288	217	40	function	function	NOUN
cusj-10288	217	41	caused	cause	VERB
cusj-10288	217	42	by	by	ADP
cusj-10288	217	43	the	the	DET
cusj-10288	217	44	expansion	expansion	NOUN
cusj-10288	217	45	of	of	ADP
cusj-10288	217	46	polyglutamine	polyglutamine	NOUN
cusj-10288	217	47	(	(	PUNCT
cusj-10288	217	48	polyq	polyq	NOUN
cusj-10288	217	49	)	)	PUNCT
cusj-10288	217	50	sequences	sequence	NOUN
cusj-10288	217	51	.	.	PUNCT
cusj-10288	218	1	the	the	DET
cusj-10288	218	2	htt	htt	NOUN
cusj-10288	218	3	protein	protein	NOUN
cusj-10288	218	4	is	be	AUX
cusj-10288	218	5	known	know	VERB
cusj-10288	218	6	to	to	PART
cusj-10288	218	7	interact	interact	VERB
cusj-10288	218	8	with	with	ADP
cusj-10288	218	9	various	various	ADJ
cusj-10288	218	10	effector	effector	NOUN
cusj-10288	218	11	proteins	protein	NOUN
cusj-10288	218	12	and	and	CCONJ
cusj-10288	218	13	is	be	AUX
cusj-10288	218	14	involved	involve	VERB
cusj-10288	218	15	in	in	ADP
cusj-10288	218	16	critical	critical	ADJ
cusj-10288	218	17	cellular	cellular	ADJ
cusj-10288	218	18	processes	process	NOUN
cusj-10288	218	19	such	such	ADJ
cusj-10288	218	20	as	as	ADP
cusj-10288	218	21	transcription	transcription	NOUN
cusj-10288	218	22	and	and	CCONJ
cusj-10288	218	23	intracellular	intracellular	ADJ
cusj-10288	218	24	trafficking	trafficking	NOUN
cusj-10288	218	25	.	.	PUNCT
cusj-10288	219	1	these	these	DET
cusj-10288	219	2	interactions	interaction	NOUN
cusj-10288	219	3	and	and	CCONJ
cusj-10288	219	4	processes	process	NOUN
cusj-10288	219	5	are	be	AUX
cusj-10288	219	6	vital	vital	ADJ
cusj-10288	219	7	for	for	ADP
cusj-10288	219	8	the	the	DET
cusj-10288	219	9	proper	proper	ADJ
cusj-10288	219	10	processing	processing	NOUN
cusj-10288	219	11	and	and	CCONJ
cusj-10288	219	12	localization	localization	NOUN
cusj-10288	219	13	of	of	ADP
cusj-10288	219	14	numerous	numerous	ADJ
cusj-10288	219	15	proteins	protein	NOUN
cusj-10288	219	16	.	.	PUNCT
cusj-10288	220	1	consequently	consequently	ADV
cusj-10288	220	2	,	,	PUNCT
cusj-10288	220	3	a	a	DET
cusj-10288	220	4	deficiency	deficiency	NOUN
cusj-10288	220	5	in	in	ADP
cusj-10288	220	6	htt	htt	NOUN
cusj-10288	220	7	function	function	NOUN
cusj-10288	220	8	could	could	AUX
cusj-10288	220	9	potentially	potentially	ADV
cusj-10288	220	10	have	have	VERB
cusj-10288	220	11	a	a	DET
cusj-10288	220	12	more	more	ADV
cusj-10288	220	13	extensive	extensive	ADJ
cusj-10288	220	14	impact	impact	NOUN
cusj-10288	220	15	on	on	ADP
cusj-10288	220	16	cellular	cellular	ADJ
cusj-10288	220	17	physiology	physiology	NOUN
cusj-10288	220	18	than	than	SCONJ
cusj-10288	220	19	previously	previously	ADV
cusj-10288	220	20	comprehended	comprehend	VERB
cusj-10288	220	21	.	.	PUNCT
cusj-10288	221	1	given	give	VERB
cusj-10288	221	2	the	the	DET
cusj-10288	221	3	variety	variety	NOUN
cusj-10288	221	4	of	of	ADP
cusj-10288	221	5	cellular	cellular	ADJ
cusj-10288	221	6	disruptions	disruption	NOUN
cusj-10288	221	7	caused	cause	VERB
cusj-10288	221	8	by	by	ADP
cusj-10288	221	9	this	this	DET
cusj-10288	221	10	deficiency	deficiency	NOUN
cusj-10288	221	11	,	,	PUNCT
cusj-10288	221	12	it	it	PRON
cusj-10288	221	13	appears	appear	VERB
cusj-10288	221	14	that	that	SCONJ
cusj-10288	221	15	certain	certain	ADJ
cusj-10288	221	16	neurons	neuron	NOUN
cusj-10288	221	17	may	may	AUX
cusj-10288	221	18	be	be	AUX
cusj-10288	221	19	more	more	ADV
cusj-10288	221	20	resilient	resilient	ADJ
cusj-10288	221	21	than	than	ADP
cusj-10288	221	22	others	other	NOUN
cusj-10288	221	23	.	.	PUNCT
cusj-10288	222	1	identifying	identify	VERB
cusj-10288	222	2	which	which	PRON
cusj-10288	222	3	altered	alter	VERB
cusj-10288	222	4	physiological	physiological	ADJ
cusj-10288	222	5	processes	process	NOUN
cusj-10288	222	6	most	most	ADV
cusj-10288	222	7	significantly	significantly	ADV
cusj-10288	222	8	contribute	contribute	VERB
cusj-10288	222	9	to	to	ADP
cusj-10288	222	10	the	the	DET
cusj-10288	222	11	progression	progression	NOUN
cusj-10288	222	12	of	of	ADP
cusj-10288	222	13	hd	hd	NOUN
cusj-10288	222	14	will	will	AUX
cusj-10288	222	15	be	be	AUX
cusj-10288	222	16	imperative	imperative	ADJ
cusj-10288	222	17	for	for	ADP
cusj-10288	222	18	the	the	DET
cusj-10288	222	19	development	development	NOUN
cusj-10288	222	20	of	of	ADP
cusj-10288	222	21	effective	effective	ADJ
cusj-10288	222	22	therapeutic	therapeutic	ADJ
cusj-10288	222	23	interventions	intervention	NOUN
cusj-10288	222	24	.	.	PUNCT
cusj-10288	223	1	as	as	SCONJ
cusj-10288	223	2	current	current	ADJ
cusj-10288	223	3	therapeutic	therapeutic	ADJ
cusj-10288	223	4	strategies	strategy	NOUN
cusj-10288	223	5	under	under	ADP
cusj-10288	223	6	development	development	NOUN
cusj-10288	223	7	aim	aim	VERB
cusj-10288	223	8	to	to	PART
cusj-10288	223	9	reduce	reduce	VERB
cusj-10288	223	10	htt	htt	NOUN
cusj-10288	223	11	levels	level	NOUN
cusj-10288	223	12	,	,	PUNCT
cusj-10288	223	13	it	it	PRON
cusj-10288	223	14	is	be	AUX
cusj-10288	223	15	also	also	ADV
cusj-10288	223	16	essential	essential	ADJ
cusj-10288	223	17	to	to	PART
cusj-10288	223	18	ascertain	ascertain	VERB
cusj-10288	223	19	the	the	DET
cusj-10288	223	20	degree	degree	NOUN
cusj-10288	223	21	to	to	PART
cusj-10288	223	22	which	which	PRON
cusj-10288	223	23	cells	cell	NOUN
cusj-10288	223	24	can	can	AUX
cusj-10288	223	25	tolerate	tolerate	VERB
cusj-10288	223	26	a	a	DET
cusj-10288	223	27	reduction	reduction	NOUN
cusj-10288	223	28	in	in	ADP
cusj-10288	223	29	normal	normal	ADJ
cusj-10288	223	30	htt	htt	NOUN
cusj-10288	223	31	expression	expression	NOUN
cusj-10288	223	32	.	.	PUNCT
cusj-10288	224	1	in	in	ADP
cusj-10288	224	2	the	the	DET
cusj-10288	224	3	field	field	NOUN
cusj-10288	224	4	of	of	ADP
cusj-10288	224	5	human	human	ADJ
cusj-10288	224	6	disease	disease	NOUN
cusj-10288	224	7	research	research	NOUN
cusj-10288	224	8	,	,	PUNCT
cusj-10288	224	9	utilizing	utilize	VERB
cusj-10288	224	10	human	human	ADJ
cusj-10288	224	11	subjects	subject	NOUN
cusj-10288	224	12	is	be	AUX
cusj-10288	224	13	considered	consider	VERB
cusj-10288	224	14	the	the	DET
cusj-10288	224	15	benchmark	benchmark	NOUN
cusj-10288	224	16	for	for	ADP
cusj-10288	224	17	validating	validate	VERB
cusj-10288	224	18	experimental	experimental	ADJ
cusj-10288	224	19	findings	finding	NOUN
cusj-10288	224	20	related	relate	VERB
cusj-10288	224	21	to	to	ADP
cusj-10288	224	22	disease	disease	NOUN
cusj-10288	224	23	pathogenesis	pathogenesis	NOUN
cusj-10288	224	24	.	.	PUNCT
cusj-10288	225	1	this	this	DET
cusj-10288	225	2	approach	approach	NOUN
cusj-10288	225	3	is	be	AUX
cusj-10288	225	4	instrumental	instrumental	ADJ
cusj-10288	225	5	in	in	ADP
cusj-10288	225	6	elucidating	elucidate	VERB
cusj-10288	225	7	the	the	DET
cusj-10288	225	8	mechanisms	mechanism	NOUN
cusj-10288	225	9	underlying	underlie	VERB
cusj-10288	225	10	disease	disease	NOUN
cusj-10288	225	11	onset	onset	VERB
cusj-10288	225	12	and	and	CCONJ
cusj-10288	225	13	in	in	ADP
cusj-10288	225	14	exploring	explore	VERB
cusj-10288	225	15	viable	viable	ADJ
cusj-10288	225	16	treatment	treatment	NOUN
cusj-10288	225	17	modalities	modality	NOUN
cusj-10288	225	18	for	for	ADP
cusj-10288	225	19	genetic	genetic	ADJ
cusj-10288	225	20	disorders	disorder	NOUN
cusj-10288	225	21	.	.	PUNCT
cusj-10288	226	1	take	take	VERB
cusj-10288	226	2	hd	hd	NOUN
cusj-10288	226	3	,	,	PUNCT
cusj-10288	226	4	for	for	ADP
cusj-10288	226	5	instance	instance	NOUN
cusj-10288	226	6	,	,	PUNCT
cusj-10288	226	7	a	a	DET
cusj-10288	226	8	genetic	genetic	ADJ
cusj-10288	226	9	condition	condition	NOUN
cusj-10288	226	10	precipitated	precipitate	VERB
cusj-10288	226	11	by	by	ADP
cusj-10288	226	12	the	the	DET
cusj-10288	226	13	incessant	incessant	ADJ
cusj-10288	226	14	elongation	elongation	NOUN
cusj-10288	226	15	of	of	ADP
cusj-10288	226	16	the	the	DET
cusj-10288	226	17	cag	cag	PROPN
cusj-10288	226	18	trinucleotide	trinucleotide	INTJ
cusj-10288	226	19	repeat	repeat	VERB
cusj-10288	226	20	within	within	ADP
cusj-10288	226	21	the	the	DET
cusj-10288	226	22	htt	htt	NOUN
cusj-10288	226	23	gene	gene	NOUN
cusj-10288	226	24	.	.	PUNCT
cusj-10288	227	1	the	the	DET
cusj-10288	227	2	extent	extent	NOUN
cusj-10288	227	3	of	of	ADP
cusj-10288	227	4	this	this	DET
cusj-10288	227	5	repeat	repeat	NOUN
cusj-10288	227	6	sequence	sequence	NOUN
cusj-10288	227	7	is	be	AUX
cusj-10288	227	8	a	a	DET
cusj-10288	227	9	determinant	determinant	NOUN
cusj-10288	227	10	of	of	ADP
cusj-10288	227	11	the	the	DET
cusj-10288	227	12	age	age	NOUN
cusj-10288	227	13	at	at	ADP
cusj-10288	227	14	which	which	PRON
cusj-10288	227	15	hd	hd	VERB
cusj-10288	227	16	symptoms	symptom	NOUN
cusj-10288	227	17	manifest	manifest	VERB
cusj-10288	227	18	,	,	PUNCT
cusj-10288	227	19	as	as	SCONJ
cusj-10288	227	20	the	the	DET
cusj-10288	227	21	accumulation	accumulation	NOUN
cusj-10288	227	22	of	of	ADP
cusj-10288	227	23	toxicity	toxicity	NOUN
cusj-10288	227	24	from	from	ADP
cusj-10288	227	25	the	the	DET
cusj-10288	227	26	expanded	expand	VERB
cusj-10288	227	27	repeat	repeat	NOUN
cusj-10288	227	28	sequence	sequence	NOUN
cusj-10288	227	29	reaches	reach	VERB
cusj-10288	227	30	a	a	DET
cusj-10288	227	31	critical	critical	ADJ
cusj-10288	227	32	threshold	threshold	NOUN
cusj-10288	227	33	,	,	PUNCT
cusj-10288	227	34	instigating	instigate	VERB
cusj-10288	227	35	cellular	cellular	ADJ
cusj-10288	227	36	damage	damage	NOUN
cusj-10288	227	37	processes	process	NOUN
cusj-10288	227	38	that	that	PRON
cusj-10288	227	39	culcolumbia	culcolumbia	PROPN
cusj-10288	227	40	undergraduate	undergraduate	PROPN
cusj-10288	227	41	science	science	PROPN
cusj-10288	227	42	journal	journal	PROPN
cusj-10288	227	43	vol	vol	NOUN
cusj-10288	227	44	.	.	PROPN
cusj-10288	227	45	17	17	NUM
cusj-10288	227	46	,	,	PUNCT
cusj-10288	227	47	2023	2023	NUM
cusj-10288	227	48	datta	datta	NOUN
cusj-10288	227	49	26	26	NUM
cusj-10288	227	50	minate	minate	NOUN
cusj-10288	227	51	in	in	ADP
cusj-10288	227	52	neuronal	neuronal	ADJ
cusj-10288	227	53	impairment	impairment	NOUN
cusj-10288	227	54	and	and	CCONJ
cusj-10288	227	55	the	the	DET
cusj-10288	227	56	onset	onset	NOUN
cusj-10288	227	57	of	of	ADP
cusj-10288	227	58	the	the	DET
cusj-10288	227	59	disease	disease	NOUN
cusj-10288	227	60	.	.	PUNCT
cusj-10288	228	1	however	however	ADV
cusj-10288	228	2	,	,	PUNCT
cusj-10288	228	3	the	the	DET
cusj-10288	228	4	length	length	NOUN
cusj-10288	228	5	of	of	ADP
cusj-10288	228	6	the	the	DET
cusj-10288	228	7	cag	cag	PROPN
cusj-10288	228	8	repeat	repeat	NOUN
cusj-10288	228	9	is	be	AUX
cusj-10288	228	10	not	not	PART
cusj-10288	228	11	static	static	ADJ
cusj-10288	228	12	;	;	PUNCT
cusj-10288	228	13	it	it	PRON
cusj-10288	228	14	is	be	AUX
cusj-10288	228	15	subject	subject	ADJ
cusj-10288	228	16	to	to	ADP
cusj-10288	228	17	somatic	somatic	ADJ
cusj-10288	228	18	expansion	expansion	NOUN
cusj-10288	228	19	influenced	influence	VERB
cusj-10288	228	20	by	by	ADP
cusj-10288	228	21	both	both	CCONJ
cusj-10288	228	22	genetic	genetic	ADJ
cusj-10288	228	23	and	and	CCONJ
cusj-10288	228	24	environmental	environmental	ADJ
cusj-10288	228	25	factors	factor	NOUN
cusj-10288	228	26	.	.	PUNCT
cusj-10288	229	1	this	this	DET
cusj-10288	229	2	variability	variability	NOUN
cusj-10288	229	3	leads	lead	VERB
cusj-10288	229	4	to	to	AUX
cusj-10288	229	5	differential	differential	VERB
cusj-10288	229	6	susceptibility	susceptibility	NOUN
cusj-10288	229	7	,	,	PUNCT
cusj-10288	229	8	damage	damage	NOUN
cusj-10288	229	9	,	,	PUNCT
cusj-10288	229	10	and	and	CCONJ
cusj-10288	229	11	toxicity	toxicity	NOUN
cusj-10288	229	12	across	across	ADP
cusj-10288	229	13	various	various	ADJ
cusj-10288	229	14	cell	cell	NOUN
cusj-10288	229	15	types	type	NOUN
cusj-10288	229	16	,	,	PUNCT
cusj-10288	229	17	resulting	result	VERB
cusj-10288	229	18	in	in	ADP
cusj-10288	229	19	diverse	diverse	ADJ
cusj-10288	229	20	phenotypic	phenotypic	ADJ
cusj-10288	229	21	expressions	expression	NOUN
cusj-10288	229	22	among	among	ADP
cusj-10288	229	23	individuals	individual	NOUN
cusj-10288	229	24	.	.	PUNCT
cusj-10288	230	1	thus	thus	ADV
cusj-10288	230	2	,	,	PUNCT
cusj-10288	230	3	the	the	DET
cusj-10288	230	4	dna	dna	PROPN
cusj-10288	230	5	repair	repair	NOUN
cusj-10288	230	6	mechanisms	mechanism	NOUN
cusj-10288	230	7	that	that	PRON
cusj-10288	230	8	govern	govern	VERB
cusj-10288	230	9	the	the	DET
cusj-10288	230	10	length	length	NOUN
cusj-10288	230	11	of	of	ADP
cusj-10288	230	12	the	the	DET
cusj-10288	230	13	cag	cag	PROPN
cusj-10288	230	14	repeat	repeat	NOUN
cusj-10288	230	15	are	be	AUX
cusj-10288	230	16	pivotal	pivotal	ADJ
cusj-10288	230	17	targets	target	NOUN
cusj-10288	230	18	for	for	ADP
cusj-10288	230	19	therapeutic	therapeutic	ADJ
cusj-10288	230	20	interventions	intervention	NOUN
cusj-10288	230	21	aimed	aim	VERB
cusj-10288	230	22	at	at	ADP
cusj-10288	230	23	delaying	delay	VERB
cusj-10288	230	24	or	or	CCONJ
cusj-10288	230	25	averting	avert	VERB
cusj-10288	230	26	the	the	DET
cusj-10288	230	27	onset	onset	NOUN
cusj-10288	230	28	of	of	ADP
cusj-10288	230	29	hd	hd	NOUN
cusj-10288	230	30	and	and	CCONJ
cusj-10288	230	31	similar	similar	ADJ
cusj-10288	230	32	trinucleotide	trinucleotide	ADJ
cusj-10288	230	33	repeat	repeat	NOUN
cusj-10288	230	34	disorders	disorder	NOUN
cusj-10288	230	35	.	.	PUNCT
cusj-10288	231	1	nonetheless	nonetheless	ADV
cusj-10288	231	2	,	,	PUNCT
cusj-10288	231	3	these	these	DET
cusj-10288	231	4	dna	dna	PROPN
cusj-10288	231	5	repair	repair	NOUN
cusj-10288	231	6	mechanisms	mechanism	NOUN
cusj-10288	231	7	are	be	AUX
cusj-10288	231	8	modulated	modulate	VERB
cusj-10288	231	9	by	by	ADP
cusj-10288	231	10	a	a	DET
cusj-10288	231	11	plethora	plethora	NOUN
cusj-10288	231	12	of	of	ADP
cusj-10288	231	13	genes	gene	NOUN
cusj-10288	231	14	that	that	PRON
cusj-10288	231	15	serve	serve	VERB
cusj-10288	231	16	as	as	ADP
cusj-10288	231	17	modifiers	modifier	NOUN
cusj-10288	231	18	of	of	ADP
cusj-10288	231	19	hd	hd	NOUN
cusj-10288	231	20	onset	onset	NOUN
cusj-10288	231	21	,	,	PUNCT
cusj-10288	231	22	complicating	complicate	VERB
cusj-10288	231	23	the	the	DET
cusj-10288	231	24	prediction	prediction	NOUN
cusj-10288	231	25	of	of	ADP
cusj-10288	231	26	disease	disease	NOUN
cusj-10288	231	27	trajectory	trajectory	NOUN
cusj-10288	231	28	for	for	ADP
cusj-10288	231	29	individual	individual	ADJ
cusj-10288	231	30	patients	patient	NOUN
cusj-10288	231	31	.	.	PUNCT
cusj-10288	232	1	furthermore	furthermore	ADV
cusj-10288	232	2	,	,	PUNCT
cusj-10288	232	3	these	these	DET
cusj-10288	232	4	modifier	modifier	NOUN
cusj-10288	232	5	genes	gene	NOUN
cusj-10288	232	6	may	may	AUX
cusj-10288	232	7	influence	influence	VERB
cusj-10288	232	8	not	not	PART
cusj-10288	232	9	only	only	ADV
cusj-10288	232	10	dna	dna	ADJ
cusj-10288	232	11	repair	repair	VERB
cusj-10288	232	12	pathways	pathway	NOUN
cusj-10288	232	13	but	but	CCONJ
cusj-10288	232	14	also	also	ADV
cusj-10288	232	15	other	other	ADJ
cusj-10288	232	16	processes	process	NOUN
cusj-10288	232	17	that	that	PRON
cusj-10288	232	18	initiate	initiate	VERB
cusj-10288	232	19	cellular	cellular	ADJ
cusj-10288	232	20	damage	damage	NOUN
cusj-10288	232	21	and	and	CCONJ
cusj-10288	232	22	toxicity	toxicity	NOUN
cusj-10288	232	23	in	in	ADP
cusj-10288	232	24	hd	hd	NOUN
cusj-10288	232	25	.	.	PUNCT
cusj-10288	233	1	another	another	DET
cusj-10288	233	2	dimension	dimension	NOUN
cusj-10288	233	3	of	of	ADP
cusj-10288	233	4	hd	hd	NOUN
cusj-10288	233	5	that	that	PRON
cusj-10288	233	6	remains	remain	VERB
cusj-10288	233	7	elusive	elusive	ADJ
cusj-10288	233	8	is	be	AUX
cusj-10288	233	9	the	the	DET
cusj-10288	233	10	normal	normal	ADJ
cusj-10288	233	11	function	function	NOUN
cusj-10288	233	12	of	of	ADP
cusj-10288	233	13	the	the	DET
cusj-10288	233	14	htt	htt	NOUN
cusj-10288	233	15	protein	protein	NOUN
cusj-10288	233	16	,	,	PUNCT
cusj-10288	233	17	which	which	PRON
cusj-10288	233	18	is	be	AUX
cusj-10288	233	19	implicated	implicate	VERB
cusj-10288	233	20	in	in	ADP
cusj-10288	233	21	synaptic	synaptic	ADJ
cusj-10288	233	22	vesicle	vesicle	NOUN
cusj-10288	233	23	trafficking	trafficking	NOUN
cusj-10288	233	24	and	and	CCONJ
cusj-10288	233	25	endosomal	endosomal	ADJ
cusj-10288	233	26	signaling	signal	VERB
cusj-10288	233	27	—	—	PUNCT
cusj-10288	233	28	processes	process	NOUN
cusj-10288	233	29	that	that	PRON
cusj-10288	233	30	are	be	AUX
cusj-10288	233	31	crucial	crucial	ADJ
cusj-10288	233	32	for	for	ADP
cusj-10288	233	33	neuronal	neuronal	ADJ
cusj-10288	233	34	development	development	NOUN
cusj-10288	233	35	and	and	CCONJ
cusj-10288	233	36	functionality	functionality	NOUN
cusj-10288	233	37	.	.	PUNCT
cusj-10288	234	1	the	the	DET
cusj-10288	234	2	precise	precise	ADJ
cusj-10288	234	3	mechanisms	mechanism	NOUN
cusj-10288	234	4	by	by	ADP
cusj-10288	234	5	which	which	PRON
cusj-10288	234	6	htt	htt	NOUN
cusj-10288	234	7	facilitates	facilitate	VERB
cusj-10288	234	8	these	these	DET
cusj-10288	234	9	synaptic	synaptic	ADJ
cusj-10288	234	10	functions	function	NOUN
cusj-10288	234	11	,	,	PUNCT
cusj-10288	234	12	and	and	CCONJ
cusj-10288	234	13	how	how	SCONJ
cusj-10288	234	14	they	they	PRON
cusj-10288	234	15	are	be	AUX
cusj-10288	234	16	disrupted	disrupt	VERB
cusj-10288	234	17	by	by	ADP
cusj-10288	234	18	the	the	DET
cusj-10288	234	19	mutant	mutant	ADJ
cusj-10288	234	20	form	form	NOUN
cusj-10288	234	21	of	of	ADP
cusj-10288	234	22	htt	htt	NOUN
cusj-10288	234	23	in	in	ADP
cusj-10288	234	24	hdafflicted	hdafflicte	VERB
cusj-10288	234	25	neurons	neuron	NOUN
cusj-10288	234	26	,	,	PUNCT
cusj-10288	234	27	are	be	AUX
cusj-10288	234	28	areas	area	NOUN
cusj-10288	234	29	that	that	PRON
cusj-10288	234	30	warrant	warrant	VERB
cusj-10288	234	31	further	further	ADJ
cusj-10288	234	32	investigation	investigation	NOUN
cusj-10288	234	33	.	.	PUNCT
cusj-10288	235	1	a	a	DET
cusj-10288	235	2	more	more	ADV
cusj-10288	235	3	thorough	thorough	ADJ
cusj-10288	235	4	characterization	characterization	NOUN
cusj-10288	235	5	of	of	ADP
cusj-10288	235	6	the	the	DET
cusj-10288	235	7	normal	normal	ADJ
cusj-10288	235	8	roles	role	NOUN
cusj-10288	235	9	of	of	ADP
cusj-10288	235	10	htt	htt	NOUN
cusj-10288	235	11	could	could	AUX
cusj-10288	235	12	unveil	unveil	VERB
cusj-10288	235	13	new	new	ADJ
cusj-10288	235	14	therapeutic	therapeutic	ADJ
cusj-10288	235	15	avenues	avenue	NOUN
cusj-10288	235	16	and	and	CCONJ
cusj-10288	235	17	foster	foster	VERB
cusj-10288	235	18	a	a	DET
cusj-10288	235	19	more	more	ADV
cusj-10288	235	20	holistic	holistic	ADJ
cusj-10288	235	21	understanding	understanding	NOUN
cusj-10288	235	22	of	of	ADP
cusj-10288	235	23	hd	hd	NOUN
cusj-10288	235	24	.	.	PUNCT
cusj-10288	235	25	.	.	PUNCT
cusj-10288	236	1	author	author	NOUN
cusj-10288	236	2	information	information	NOUN
cusj-10288	236	3	corresponding	correspond	VERB
cusj-10288	236	4	author	author	NOUN
cusj-10288	236	5	neelabh	neelabh	PROPN
cusj-10288	236	6	datta	datta	PROPN
cusj-10288	236	7	neelabhdatta@gmail.com	neelabhdatta@gmail.com	X
cusj-10288	237	1	author	author	NOUN
cusj-10288	237	2	contributions	contribution	NOUN
cusj-10288	237	3	text	text	NOUN
cusj-10288	237	4	.	.	PUNCT
cusj-10288	238	1	references	reference	NOUN
cusj-10288	238	2	[	[	X
cusj-10288	238	3	1	1	NUM
cusj-10288	238	4	]	]	PUNCT
cusj-10288	238	5	myers	myer	NOUN
cusj-10288	238	6	,	,	PUNCT
cusj-10288	238	7	r.	r.	PROPN
cusj-10288	238	8	h.	h.	PROPN
cusj-10288	238	9	,	,	PUNCT
cusj-10288	238	10	macdonald	macdonald	PROPN
cusj-10288	238	11	,	,	PUNCT
cusj-10288	238	12	m.	m.	PROPN
cusj-10288	238	13	e.	e.	PROPN
cusj-10288	238	14	,	,	PUNCT
cusj-10288	238	15	koroshetz	koroshetz	PROPN
cusj-10288	238	16	,	,	PUNCT
cusj-10288	238	17	w.	w.	PROPN
cusj-10288	238	18	j.	j.	PROPN
cusj-10288	238	19	,	,	PUNCT
cusj-10288	238	20	duyao	duyao	NOUN
cusj-10288	238	21	,	,	PUNCT
cusj-10288	238	22	m.	m.	NOUN
cusj-10288	238	23	p.	p.	PROPN
cusj-10288	238	24	,	,	PUNCT
cusj-10288	238	25	ambrose	ambrose	PROPN
cusj-10288	238	26	,	,	PUNCT
cusj-10288	238	27	c.	c.	PROPN
cusj-10288	238	28	m.	m.	PROPN
cusj-10288	238	29	,	,	PUNCT
cusj-10288	238	30	taylor	taylor	PROPN
cusj-10288	238	31	,	,	PUNCT
cusj-10288	238	32	s.	s.	PROPN
cusj-10288	238	33	a.	a.	PROPN
cusj-10288	238	34	,	,	PUNCT
cusj-10288	238	35	barnes	barnes	PROPN
cusj-10288	238	36	,	,	PUNCT
cusj-10288	238	37	g.	g.	PROPN
cusj-10288	238	38	,	,	PUNCT
cusj-10288	238	39	srinidhi	srinidhi	PROPN
cusj-10288	238	40	,	,	PUNCT
cusj-10288	238	41	j.	j.	PROPN
cusj-10288	238	42	,	,	PUNCT
cusj-10288	238	43	lin	lin	PROPN
cusj-10288	238	44	,	,	PUNCT
cusj-10288	238	45	c.	c.	PROPN
cusj-10288	238	46	s.	s.	PROPN
cusj-10288	238	47	,	,	PUNCT
cusj-10288	238	48	&	&	CCONJ
cusj-10288	238	49	whaley	whaley	PROPN
cusj-10288	238	50	,	,	PUNCT
cusj-10288	238	51	w.	w.	PROPN
cusj-10288	238	52	l.	l.	PROPN
cusj-10288	238	53	(	(	PUNCT
cusj-10288	238	54	1993	1993	NUM
cusj-10288	238	55	)	)	PUNCT
cusj-10288	238	56	.	.	PUNCT
cusj-10288	239	1	de	de	PROPN
cusj-10288	239	2	novo	novo	PROPN
cusj-10288	239	3	expansion	expansion	NOUN
cusj-10288	239	4	of	of	ADP
cusj-10288	239	5	a	a	DET
cusj-10288	239	6	(	(	PUNCT
cusj-10288	239	7	cag)n	cag)n	NOUN
cusj-10288	239	8	repeat	repeat	NOUN
cusj-10288	239	9	in	in	ADP
cusj-10288	239	10	sporadic	sporadic	ADJ
cusj-10288	239	11	huntington	huntington	PROPN
cusj-10288	239	12	's	's	PART
cusj-10288	239	13	disease	disease	NOUN
cusj-10288	239	14	.	.	PUNCT
cusj-10288	240	1	nature	nature	NOUN
cusj-10288	240	2	genetics	genetic	NOUN
cusj-10288	240	3	,	,	PUNCT
cusj-10288	240	4	5(2	5(2	NUM
cusj-10288	240	5	)	)	PUNCT
cusj-10288	240	6	,	,	PUNCT
cusj-10288	240	7	168–173	168–173	NUM
cusj-10288	240	8	.	.	PUNCT
cusj-10288	241	1	https://doi.org/10.1038/ng1093168	https://doi.org/10.1038/ng1093168	NOUN
cusj-10288	241	2	.	.	PUNCT
cusj-10288	242	1	[	[	X
cusj-10288	242	2	2	2	NUM
cusj-10288	242	3	]	]	X
cusj-10288	242	4	schulte	schulte	PROPN
cusj-10288	242	5	,	,	PUNCT
cusj-10288	242	6	j.	j.	PROPN
cusj-10288	242	7	,	,	PUNCT
cusj-10288	242	8	&	&	CCONJ
cusj-10288	242	9	littleton	littleton	PROPN
cusj-10288	242	10	,	,	PUNCT
cusj-10288	242	11	j.	j.	PROPN
cusj-10288	242	12	t.	t.	PROPN
cusj-10288	242	13	(	(	PUNCT
cusj-10288	242	14	2011	2011	NUM
cusj-10288	242	15	)	)	PUNCT
cusj-10288	242	16	.	.	PUNCT
cusj-10288	243	1	the	the	DET
cusj-10288	243	2	biological	biological	ADJ
cusj-10288	243	3	function	function	NOUN
cusj-10288	243	4	of	of	ADP
cusj-10288	243	5	the	the	DET
cusj-10288	243	6	huntingtin	huntingtin	NOUN
cusj-10288	243	7	protein	protein	NOUN
cusj-10288	243	8	and	and	CCONJ
cusj-10288	243	9	its	its	PRON
cusj-10288	243	10	relevance	relevance	NOUN
cusj-10288	243	11	to	to	ADP
cusj-10288	243	12	huntington	huntington	PROPN
cusj-10288	243	13	's	's	PART
cusj-10288	243	14	disease	disease	NOUN
cusj-10288	243	15	pathology	pathology	NOUN
cusj-10288	243	16	.	.	PUNCT
cusj-10288	244	1	current	current	ADJ
cusj-10288	244	2	trends	trend	NOUN
cusj-10288	244	3	in	in	ADP
cusj-10288	244	4	neurology	neurology	NOUN
cusj-10288	244	5	,	,	PUNCT
cusj-10288	244	6	5	5	NUM
cusj-10288	244	7	,	,	PUNCT
cusj-10288	244	8	65–78	65–78	NUM
cusj-10288	244	9	.	.	PUNCT
cusj-10288	245	1	[	[	X
cusj-10288	245	2	3	3	NUM
cusj-10288	245	3	]	]	X
cusj-10288	245	4	myers	myers	PROPN
cusj-10288	245	5	r.	r.	PROPN
cusj-10288	245	6	h.	h.	PROPN
cusj-10288	245	7	(	(	PUNCT
cusj-10288	245	8	2004	2004	NUM
cusj-10288	245	9	)	)	PUNCT
cusj-10288	245	10	.	.	PUNCT
cusj-10288	246	1	huntington	huntington	PROPN
cusj-10288	246	2	's	's	PART
cusj-10288	246	3	disease	disease	NOUN
cusj-10288	246	4	genetics	genetic	NOUN
cusj-10288	246	5	.	.	PUNCT
cusj-10288	247	1	neurorx	neurorx	PROPN
cusj-10288	247	2	:	:	PUNCT
cusj-10288	247	3	the	the	DET
cusj-10288	247	4	journal	journal	NOUN
cusj-10288	247	5	of	of	ADP
cusj-10288	247	6	the	the	DET
cusj-10288	247	7	american	american	ADJ
cusj-10288	247	8	society	society	NOUN
cusj-10288	247	9	for	for	ADP
cusj-10288	247	10	experimental	experimental	ADJ
cusj-10288	247	11	neurotherapeutics	neurotherapeutic	NOUN
cusj-10288	247	12	,	,	PUNCT
cusj-10288	247	13	1(2	1(2	NUM
cusj-10288	247	14	)	)	PUNCT
cusj-10288	247	15	,	,	PUNCT
cusj-10288	247	16	255–262	255–262	NUM
cusj-10288	247	17	.	.	PUNCT
cusj-10288	248	1	https://doi.org/10.1602/neurorx.1.2.255	https://doi.org/10.1602/neurorx.1.2.255	PROPN
cusj-10288	248	2	.	.	PUNCT
cusj-10288	249	1	[	[	X
cusj-10288	249	2	4	4	NUM
cusj-10288	249	3	]	]	X
cusj-10288	249	4	squitieri	squitieri	PROPN
cusj-10288	249	5	,	,	PUNCT
cusj-10288	249	6	f.	f.	PROPN
cusj-10288	249	7	,	,	PUNCT
cusj-10288	249	8	cannella	cannella	PROPN
cusj-10288	249	9	,	,	PUNCT
cusj-10288	249	10	m.	m.	NOUN
cusj-10288	249	11	,	,	PUNCT
cusj-10288	249	12	&	&	CCONJ
cusj-10288	249	13	simonelli	simonelli	PROPN
cusj-10288	249	14	,	,	PUNCT
cusj-10288	249	15	m.	m.	NOUN
cusj-10288	249	16	(	(	PUNCT
cusj-10288	249	17	2002	2002	NUM
cusj-10288	249	18	)	)	PUNCT
cusj-10288	249	19	.	.	PUNCT
cusj-10288	250	1	cag	cag	PROPN
cusj-10288	250	2	mutation	mutation	PROPN
cusj-10288	250	3	effect	effect	NOUN
cusj-10288	250	4	on	on	ADP
cusj-10288	250	5	rate	rate	NOUN
cusj-10288	250	6	of	of	ADP
cusj-10288	250	7	progression	progression	NOUN
cusj-10288	250	8	in	in	ADP
cusj-10288	250	9	huntington	huntington	PROPN
cusj-10288	250	10	's	's	PART
cusj-10288	250	11	disease	disease	NOUN
cusj-10288	250	12	.	.	PUNCT
cusj-10288	251	1	neurological	neurological	ADJ
cusj-10288	251	2	sciences	science	NOUN
cusj-10288	251	3	:	:	PUNCT
cusj-10288	251	4	official	official	ADJ
cusj-10288	251	5	journal	journal	NOUN
cusj-10288	251	6	of	of	ADP
cusj-10288	251	7	the	the	DET
cusj-10288	251	8	italian	italian	ADJ
cusj-10288	251	9	neurological	neurological	ADJ
cusj-10288	251	10	society	society	NOUN
cusj-10288	251	11	and	and	CCONJ
cusj-10288	251	12	of	of	ADP
cusj-10288	251	13	the	the	DET
cusj-10288	251	14	italian	italian	ADJ
cusj-10288	251	15	society	society	NOUN
cusj-10288	251	16	of	of	ADP
cusj-10288	251	17	clinical	clinical	ADJ
cusj-10288	251	18	neurophysiology	neurophysiology	NOUN
cusj-10288	251	19	,	,	PUNCT
cusj-10288	251	20	23	23	NUM
cusj-10288	251	21	suppl	suppl	ADJ
cusj-10288	251	22	2	2	NUM
cusj-10288	251	23	,	,	PUNCT
cusj-10288	251	24	s107	s107	PROPN
cusj-10288	251	25	–	–	PUNCT
cusj-10288	251	26	s108	s108	PROPN
cusj-10288	251	27	.	.	PUNCT
cusj-10288	252	1	https://doi.org/10.1007/s100720200092	https://doi.org/10.1007/s100720200092	NOUN
cusj-10288	253	1	[	[	X
cusj-10288	253	2	5	5	NUM
cusj-10288	253	3	]	]	X
cusj-10288	253	4	rubinsztein	rubinsztein	PROPN
cusj-10288	253	5	,	,	PUNCT
cusj-10288	253	6	d.	d.	PROPN
cusj-10288	253	7	c.	c.	PROPN
cusj-10288	253	8	,	,	PUNCT
cusj-10288	253	9	leggo	leggo	PROPN
cusj-10288	253	10	,	,	PUNCT
cusj-10288	253	11	j.	j.	PROPN
cusj-10288	253	12	,	,	PUNCT
cusj-10288	253	13	chiano	chiano	PROPN
cusj-10288	253	14	,	,	PUNCT
cusj-10288	253	15	m.	m.	NOUN
cusj-10288	253	16	,	,	PUNCT
cusj-10288	253	17	korn	korn	PROPN
cusj-10288	253	18	,	,	PUNCT
cusj-10288	253	19	s.	s.	PROPN
cusj-10288	253	20	,	,	PUNCT
cusj-10288	253	21	dodge	dodge	PROPN
cusj-10288	253	22	,	,	PUNCT
cusj-10288	253	23	a.	a.	NOUN
cusj-10288	253	24	,	,	PUNCT
cusj-10288	253	25	norbury	norbury	PROPN
cusj-10288	253	26	,	,	PUNCT
cusj-10288	253	27	g.	g.	PROPN
cusj-10288	253	28	,	,	PUNCT
cusj-10288	253	29	rosser	rosser	PROPN
cusj-10288	253	30	,	,	PUNCT
cusj-10288	253	31	e.	e.	PROPN
cusj-10288	253	32	,	,	PUNCT
cusj-10288	253	33	&	&	CCONJ
cusj-10288	253	34	craufurd	craufurd	PROPN
cusj-10288	253	35	,	,	PUNCT
cusj-10288	253	36	d.	d.	PROPN
cusj-10288	253	37	(	(	PUNCT
cusj-10288	253	38	1997	1997	NUM
cusj-10288	253	39	)	)	PUNCT
cusj-10288	253	40	.	.	PUNCT
cusj-10288	254	1	homozygotes	homozygote	NOUN
cusj-10288	254	2	and	and	CCONJ
cusj-10288	254	3	heterozygotes	heterozygote	NOUN
cusj-10288	254	4	for	for	ADP
cusj-10288	254	5	ciliary	ciliary	ADJ
cusj-10288	254	6	neurotrophic	neurotrophic	ADJ
cusj-10288	254	7	factor	factor	NOUN
cusj-10288	254	8	null	null	ADJ
cusj-10288	254	9	alleles	allele	NOUN
cusj-10288	254	10	do	do	AUX
cusj-10288	254	11	not	not	PART
cusj-10288	254	12	show	show	VERB
cusj-10288	254	13	earlier	early	ADJ
cusj-10288	254	14	onset	onset	NOUN
cusj-10288	254	15	of	of	ADP
cusj-10288	254	16	huntington	huntington	PROPN
cusj-10288	254	17	's	's	PART
cusj-10288	254	18	disease	disease	NOUN
cusj-10288	254	19	.	.	PUNCT
cusj-10288	255	1	neurology	neurology	NOUN
cusj-10288	255	2	,	,	PUNCT
cusj-10288	255	3	49(3	49(3	PROPN
cusj-10288	255	4	)	)	PUNCT
cusj-10288	255	5	,	,	PUNCT
cusj-10288	255	6	890	890	NUM
cusj-10288	255	7	–	–	PUNCT
cusj-10288	255	8	892	892	NUM
cusj-10288	255	9	.	.	PUNCT
cusj-10288	256	1	https://doi.org/10.1212/wnl.49.3.890	https://doi.org/10.1212/wnl.49.3.890	NOUN
cusj-10288	256	2	.	.	PUNCT
cusj-10288	257	1	[	[	X
cusj-10288	257	2	6	6	NUM
cusj-10288	257	3	]	]	X
cusj-10288	257	4	albin	albin	PROPN
cusj-10288	257	5	,	,	PUNCT
cusj-10288	257	6	r.	r.	PROPN
cusj-10288	257	7	l.	l.	PROPN
cusj-10288	257	8	,	,	PUNCT
cusj-10288	257	9	reiner	reiner	NOUN
cusj-10288	257	10	,	,	PUNCT
cusj-10288	257	11	a.	a.	PROPN
cusj-10288	257	12	,	,	PUNCT
cusj-10288	257	13	anderson	anderson	PROPN
cusj-10288	257	14	,	,	PUNCT
cusj-10288	257	15	k.	k.	PROPN
cusj-10288	257	16	d.	d.	PROPN
cusj-10288	257	17	,	,	PUNCT
cusj-10288	257	18	dure	dure	PROPN
cusj-10288	257	19	,	,	PUNCT
cusj-10288	257	20	l.	l.	PROPN
cusj-10288	257	21	s.	s.	PROPN
cusj-10288	257	22	,	,	PUNCT
cusj-10288	257	23	4th	4th	ADJ
cusj-10288	257	24	,	,	PUNCT
cusj-10288	257	25	handelin	handelin	PROPN
cusj-10288	257	26	,	,	PUNCT
cusj-10288	257	27	b.	b.	PROPN
cusj-10288	257	28	,	,	PUNCT
cusj-10288	257	29	balfour	balfour	PROPN
cusj-10288	257	30	,	,	PUNCT
cusj-10288	257	31	r.	r.	PROPN
cusj-10288	257	32	,	,	PUNCT
cusj-10288	257	33	whetsell	whetsell	PROPN
cusj-10288	257	34	,	,	PUNCT
cusj-10288	257	35	w.	w.	PROPN
cusj-10288	257	36	o.	o.	PROPN
cusj-10288	257	37	,	,	PUNCT
cusj-10288	257	38	jr	jr	PROPN
cusj-10288	257	39	,	,	PUNCT
cusj-10288	257	40	penney	penney	PROPN
cusj-10288	257	41	,	,	PUNCT
cusj-10288	257	42	j.	j.	PROPN
cusj-10288	257	43	b.	b.	PROPN
cusj-10288	257	44	,	,	PUNCT
cusj-10288	257	45	&	&	CCONJ
cusj-10288	257	46	young	young	ADJ
cusj-10288	257	47	,	,	PUNCT
cusj-10288	257	48	a.	a.	PROPN
cusj-10288	257	49	b.	b.	PROPN
cusj-10288	257	50	(	(	PUNCT
cusj-10288	257	51	1992	1992	NUM
cusj-10288	257	52	)	)	PUNCT
cusj-10288	257	53	.	.	PUNCT
cusj-10288	258	1	preferential	preferential	ADJ
cusj-10288	258	2	loss	loss	NOUN
cusj-10288	258	3	of	of	ADP
cusj-10288	258	4	striatoexternal	striatoexternal	ADJ
cusj-10288	258	5	pallidal	pallidal	ADJ
cusj-10288	258	6	projection	projection	NOUN
cusj-10288	258	7	neurons	neuron	NOUN
cusj-10288	258	8	in	in	ADP
cusj-10288	258	9	presymptomatic	presymptomatic	PROPN
cusj-10288	258	10	huntington	huntington	PROPN
cusj-10288	258	11	's	's	PART
cusj-10288	258	12	disease	disease	NOUN
cusj-10288	258	13	.	.	PUNCT
cusj-10288	259	1	annals	annal	NOUN
cusj-10288	259	2	of	of	ADP
cusj-10288	259	3	neurology	neurology	NOUN
cusj-10288	259	4	,	,	PUNCT
cusj-10288	259	5	31(4	31(4	NUM
cusj-10288	259	6	)	)	PUNCT
cusj-10288	259	7	,	,	PUNCT
cusj-10288	259	8	425–430	425–430	NUM
cusj-10288	259	9	.	.	PUNCT
cusj-10288	260	1	https://doi.org/10.1002/ana.410310412	https://doi.org/10.1002/ana.410310412	PROPN
cusj-10288	260	2	.	.	PUNCT
cusj-10288	261	1	columbia	columbia	PROPN
cusj-10288	261	2	undergraduate	undergraduate	PROPN
cusj-10288	261	3	science	science	PROPN
cusj-10288	261	4	journal	journal	PROPN
cusj-10288	261	5	vol	vol	NOUN
cusj-10288	261	6	.	.	PROPN
cusj-10288	261	7	17	17	NUM
cusj-10288	261	8	,	,	PUNCT
cusj-10288	261	9	2023	2023	NUM
cusj-10288	261	10	datta	datta	NOUN
cusj-10288	261	11	27	27	NUM
cusj-10288	262	1	[	[	X
cusj-10288	262	2	7	7	NUM
cusj-10288	262	3	]	]	SYM
cusj-10288	262	4	sapp	sapp	PROPN
cusj-10288	262	5	,	,	PUNCT
cusj-10288	262	6	e.	e.	PROPN
cusj-10288	262	7	,	,	PUNCT
cusj-10288	262	8	kegel	kegel	PROPN
cusj-10288	262	9	,	,	PUNCT
cusj-10288	262	10	k.	k.	PROPN
cusj-10288	262	11	b.	b.	PROPN
cusj-10288	262	12	,	,	PUNCT
cusj-10288	262	13	aronin	aronin	PROPN
cusj-10288	262	14	,	,	PUNCT
cusj-10288	262	15	n.	n.	NOUN
cusj-10288	262	16	,	,	PUNCT
cusj-10288	262	17	hashikawa	hashikawa	PROPN
cusj-10288	262	18	,	,	PUNCT
cusj-10288	262	19	t.	t.	NOUN
cusj-10288	262	20	,	,	PUNCT
cusj-10288	262	21	uchiyama	uchiyama	NOUN
cusj-10288	262	22	,	,	PUNCT
cusj-10288	262	23	y.	y.	NOUN
cusj-10288	262	24	,	,	PUNCT
cusj-10288	262	25	tohyama	tohyama	PROPN
cusj-10288	262	26	,	,	PUNCT
cusj-10288	262	27	k.	k.	PROPN
cusj-10288	262	28	,	,	PUNCT
cusj-10288	262	29	bhide	bhide	ADV
cusj-10288	262	30	,	,	PUNCT
cusj-10288	262	31	p.	p.	PROPN
cusj-10288	262	32	g.	g.	PROPN
cusj-10288	262	33	,	,	PUNCT
cusj-10288	262	34	vonsattel	vonsattel	NOUN
cusj-10288	262	35	,	,	PUNCT
cusj-10288	262	36	j.	j.	PROPN
cusj-10288	262	37	p.	p.	PROPN
cusj-10288	262	38	,	,	PUNCT
cusj-10288	262	39	&	&	CCONJ
cusj-10288	262	40	difiglia	difiglia	PROPN
cusj-10288	262	41	,	,	PUNCT
cusj-10288	262	42	m.	m.	NOUN
cusj-10288	262	43	(	(	PUNCT
cusj-10288	262	44	2001	2001	NUM
cusj-10288	262	45	)	)	PUNCT
cusj-10288	262	46	.	.	PUNCT
cusj-10288	263	1	early	early	ADJ
cusj-10288	263	2	and	and	CCONJ
cusj-10288	263	3	progressive	progressive	ADJ
cusj-10288	263	4	accumulation	accumulation	NOUN
cusj-10288	263	5	of	of	ADP
cusj-10288	263	6	reactive	reactive	ADJ
cusj-10288	263	7	microglia	microglia	NOUN
cusj-10288	263	8	in	in	ADP
cusj-10288	263	9	the	the	DET
cusj-10288	263	10	huntington	huntington	PROPN
cusj-10288	263	11	disease	disease	NOUN
cusj-10288	263	12	brain	brain	PROPN
cusj-10288	263	13	.	.	PUNCT
cusj-10288	264	1	journal	journal	PROPN
cusj-10288	264	2	of	of	ADP
cusj-10288	264	3	neuropathology	neuropathology	NOUN
cusj-10288	264	4	and	and	CCONJ
cusj-10288	264	5	experimental	experimental	ADJ
cusj-10288	264	6	neurology	neurology	NOUN
cusj-10288	264	7	,	,	PUNCT
cusj-10288	264	8	60(2	60(2	NUM
cusj-10288	264	9	)	)	PUNCT
cusj-10288	264	10	,	,	PUNCT
cusj-10288	264	11	161–172	161–172	NUM
cusj-10288	264	12	.	.	PUNCT
cusj-10288	265	1	https://doi.org/10.1093/jnen/60.2.161	https://doi.org/10.1093/jnen/60.2.161	VERB
cusj-10288	265	2	.	.	PUNCT
cusj-10288	266	1	[	[	X
cusj-10288	266	2	8	8	NUM
cusj-10288	266	3	]	]	SYM
cusj-10288	266	4	vonsattel	vonsattel	NOUN
cusj-10288	266	5	,	,	PUNCT
cusj-10288	266	6	j.	j.	PROPN
cusj-10288	266	7	p.	p.	PROPN
cusj-10288	266	8	,	,	PUNCT
cusj-10288	266	9	myers	myers	PROPN
cusj-10288	266	10	,	,	PUNCT
cusj-10288	266	11	r.	r.	PROPN
cusj-10288	266	12	h.	h.	PROPN
cusj-10288	266	13	,	,	PUNCT
cusj-10288	266	14	stevens	stevens	PROPN
cusj-10288	266	15	,	,	PUNCT
cusj-10288	266	16	t.	t.	PROPN
cusj-10288	266	17	j.	j.	PROPN
cusj-10288	266	18	,	,	PUNCT
cusj-10288	266	19	ferrante	ferrante	PROPN
cusj-10288	266	20	,	,	PUNCT
cusj-10288	266	21	r.	r.	PROPN
cusj-10288	266	22	j.	j.	PROPN
cusj-10288	266	23	,	,	PUNCT
cusj-10288	266	24	bird	bird	PROPN
cusj-10288	266	25	,	,	PUNCT
cusj-10288	266	26	e.	e.	PROPN
cusj-10288	266	27	d.	d.	PROPN
cusj-10288	266	28	,	,	PUNCT
cusj-10288	266	29	&	&	CCONJ
cusj-10288	266	30	richardson	richardson	PROPN
cusj-10288	266	31	,	,	PUNCT
cusj-10288	266	32	e.	e.	PROPN
cusj-10288	266	33	p.	p.	PROPN
cusj-10288	266	34	,	,	PUNCT
cusj-10288	266	35	jr	jr	PROPN
cusj-10288	266	36	(	(	PUNCT
cusj-10288	266	37	1985	1985	NUM
cusj-10288	266	38	)	)	PUNCT
cusj-10288	266	39	.	.	PUNCT
cusj-10288	267	1	neuropathological	neuropathological	ADJ
cusj-10288	267	2	classification	classification	NOUN
cusj-10288	267	3	of	of	ADP
cusj-10288	267	4	huntington	huntington	PROPN
cusj-10288	267	5	's	's	PART
cusj-10288	267	6	disease	disease	NOUN
cusj-10288	267	7	.	.	PUNCT
cusj-10288	268	1	journal	journal	PROPN
cusj-10288	268	2	of	of	ADP
cusj-10288	268	3	neuropathology	neuropathology	NOUN
cusj-10288	268	4	and	and	CCONJ
cusj-10288	268	5	experimental	experimental	ADJ
cusj-10288	268	6	neurology	neurology	NOUN
cusj-10288	268	7	,	,	PUNCT
cusj-10288	268	8	44(6	44(6	PROPN
cusj-10288	268	9	)	)	PUNCT
cusj-10288	268	10	,	,	PUNCT
cusj-10288	268	11	559–577	559–577	NUM
cusj-10288	268	12	.	.	PUNCT
cusj-10288	269	1	https://doi.org/10.1097/00005072198511000-00003	https://doi.org/10.1097/00005072198511000-00003	PROPN
cusj-10288	269	2	.	.	PUNCT
cusj-10288	270	1	[	[	X
cusj-10288	270	2	9	9	NUM
cusj-10288	270	3	]	]	X
cusj-10288	270	4	nopoulos	nopoulo	NOUN
cusj-10288	270	5	,	,	PUNCT
cusj-10288	270	6	p.	p.	PROPN
cusj-10288	270	7	c.	c.	PROPN
cusj-10288	270	8	,	,	PUNCT
cusj-10288	270	9	aylward	aylward	PROPN
cusj-10288	270	10	,	,	PUNCT
cusj-10288	270	11	e.	e.	PROPN
cusj-10288	270	12	h.	h.	PROPN
cusj-10288	270	13	,	,	PUNCT
cusj-10288	270	14	ross	ross	PROPN
cusj-10288	270	15	,	,	PUNCT
cusj-10288	270	16	c.	c.	PROPN
cusj-10288	270	17	a.	a.	PROPN
cusj-10288	270	18	,	,	PUNCT
cusj-10288	270	19	johnson	johnson	PROPN
cusj-10288	270	20	,	,	PUNCT
cusj-10288	270	21	h.	h.	PROPN
cusj-10288	270	22	j.	j.	PROPN
cusj-10288	270	23	,	,	PUNCT
cusj-10288	270	24	magnotta	magnotta	NOUN
cusj-10288	270	25	,	,	PUNCT
cusj-10288	270	26	v.	v.	PROPN
cusj-10288	270	27	a.	a.	PROPN
cusj-10288	270	28	,	,	PUNCT
cusj-10288	270	29	juhl	juhl	PROPN
cusj-10288	270	30	,	,	PUNCT
cusj-10288	270	31	a.	a.	PROPN
cusj-10288	270	32	r.	r.	PROPN
cusj-10288	270	33	,	,	PUNCT
cusj-10288	270	34	pierson	pierson	PROPN
cusj-10288	270	35	,	,	PUNCT
cusj-10288	270	36	r.	r.	PROPN
cusj-10288	270	37	k.	k.	PROPN
cusj-10288	270	38	,	,	PUNCT
cusj-10288	270	39	mills	mills	PROPN
cusj-10288	270	40	,	,	PUNCT
cusj-10288	270	41	j.	j.	PROPN
cusj-10288	270	42	,	,	PUNCT
cusj-10288	270	43	langbehn	langbehn	PROPN
cusj-10288	270	44	,	,	PUNCT
cusj-10288	270	45	d.	d.	PROPN
cusj-10288	270	46	r.	r.	PROPN
cusj-10288	270	47	,	,	PUNCT
cusj-10288	270	48	paulsen	paulsen	PROPN
cusj-10288	270	49	,	,	PUNCT
cusj-10288	270	50	j.	j.	PROPN
cusj-10288	270	51	s.	s.	PROPN
cusj-10288	270	52	,	,	PUNCT
cusj-10288	270	53	&	&	CCONJ
cusj-10288	270	54	predict	predict	VERB
cusj-10288	270	55	-	-	PUNCT
cusj-10288	270	56	hd	hd	VERB
cusj-10288	270	57	investigators	investigator	NOUN
cusj-10288	270	58	coordinators	coordinator	NOUN
cusj-10288	270	59	of	of	ADP
cusj-10288	270	60	huntington	huntington	PROPN
cusj-10288	270	61	study	study	PROPN
cusj-10288	270	62	group	group	NOUN
cusj-10288	270	63	(	(	PUNCT
cusj-10288	270	64	hsg	hsg	PROPN
cusj-10288	270	65	)	)	PUNCT
cusj-10288	270	66	(	(	PUNCT
cusj-10288	270	67	2010	2010	NUM
cusj-10288	270	68	)	)	PUNCT
cusj-10288	270	69	.	.	PUNCT
cusj-10288	271	1	cerebral	cerebral	ADJ
cusj-10288	271	2	cortex	cortex	NOUN
cusj-10288	271	3	structure	structure	NOUN
cusj-10288	271	4	in	in	ADP
cusj-10288	271	5	prodromal	prodromal	ADJ
cusj-10288	271	6	huntington	huntington	PROPN
cusj-10288	271	7	disease	disease	NOUN
cusj-10288	271	8	.	.	PUNCT
cusj-10288	272	1	neurobiology	neurobiology	NOUN
cusj-10288	272	2	of	of	ADP
cusj-10288	272	3	disease	disease	NOUN
cusj-10288	272	4	,	,	PUNCT
cusj-10288	272	5	40(3	40(3	NUM
cusj-10288	272	6	)	)	PUNCT
cusj-10288	272	7	,	,	PUNCT
cusj-10288	272	8	544–554	544–554	NUM
cusj-10288	272	9	.	.	PUNCT
cusj-10288	273	1	https://doi.org/10.1016/j.nbd.2010.07.014	https://doi.org/10.1016/j.nbd.2010.07.014	VERB
cusj-10288	273	2	.	.	PUNCT
cusj-10288	274	1	[	[	X
cusj-10288	274	2	10	10	NUM
cusj-10288	274	3	]	]	X
cusj-10288	274	4	squitieri	squitieri	PROPN
cusj-10288	274	5	,	,	PUNCT
cusj-10288	274	6	f.	f.	PROPN
cusj-10288	274	7	,	,	PUNCT
cusj-10288	274	8	cannella	cannella	PROPN
cusj-10288	274	9	,	,	PUNCT
cusj-10288	274	10	m.	m.	NOUN
cusj-10288	274	11	,	,	PUNCT
cusj-10288	274	12	simonelli	simonelli	PROPN
cusj-10288	274	13	,	,	PUNCT
cusj-10288	274	14	m.	m.	NOUN
cusj-10288	274	15	,	,	PUNCT
cusj-10288	274	16	sassone	sassone	PROPN
cusj-10288	274	17	,	,	PUNCT
cusj-10288	274	18	j.	j.	PROPN
cusj-10288	274	19	,	,	PUNCT
cusj-10288	274	20	martino	martino	PROPN
cusj-10288	274	21	,	,	PUNCT
cusj-10288	274	22	t.	t.	PROPN
cusj-10288	274	23	,	,	PUNCT
cusj-10288	274	24	venditti	venditti	PROPN
cusj-10288	274	25	,	,	PUNCT
cusj-10288	274	26	e.	e.	PROPN
cusj-10288	274	27	,	,	PUNCT
cusj-10288	274	28	ciammola	ciammola	PROPN
cusj-10288	274	29	,	,	PUNCT
cusj-10288	274	30	a.	a.	PROPN
cusj-10288	274	31	,	,	PUNCT
cusj-10288	274	32	colonnese	colonnese	NOUN
cusj-10288	274	33	,	,	PUNCT
cusj-10288	274	34	c.	c.	PROPN
cusj-10288	274	35	,	,	PUNCT
cusj-10288	274	36	frati	frati	PROPN
cusj-10288	274	37	,	,	PUNCT
cusj-10288	274	38	l.	l.	PROPN
cusj-10288	274	39	,	,	PUNCT
cusj-10288	274	40	&	&	CCONJ
cusj-10288	274	41	ciarmiello	ciarmiello	PROPN
cusj-10288	274	42	,	,	PUNCT
cusj-10288	274	43	a.	a.	NOUN
cusj-10288	274	44	(	(	PUNCT
cusj-10288	274	45	2009	2009	NUM
cusj-10288	274	46	)	)	PUNCT
cusj-10288	274	47	.	.	PUNCT
cusj-10288	275	1	distinct	distinct	ADJ
cusj-10288	275	2	brain	brain	NOUN
cusj-10288	275	3	volume	volume	NOUN
cusj-10288	275	4	changes	change	NOUN
cusj-10288	275	5	correlating	correlate	VERB
cusj-10288	275	6	with	with	ADP
cusj-10288	275	7	clinical	clinical	ADJ
cusj-10288	275	8	stage	stage	NOUN
cusj-10288	275	9	,	,	PUNCT
cusj-10288	275	10	disease	disease	NOUN
cusj-10288	275	11	progression	progression	NOUN
cusj-10288	275	12	rate	rate	NOUN
cusj-10288	275	13	,	,	PUNCT
cusj-10288	275	14	mutation	mutation	NOUN
cusj-10288	275	15	size	size	NOUN
cusj-10288	275	16	,	,	PUNCT
cusj-10288	275	17	and	and	CCONJ
cusj-10288	275	18	age	age	NOUN
cusj-10288	275	19	at	at	ADP
cusj-10288	275	20	onset	onset	NOUN
cusj-10288	275	21	prediction	prediction	NOUN
cusj-10288	275	22	as	as	ADP
cusj-10288	275	23	early	early	ADJ
cusj-10288	275	24	biomarkers	biomarker	NOUN
cusj-10288	275	25	of	of	ADP
cusj-10288	275	26	brain	brain	NOUN
cusj-10288	275	27	atrophy	atrophy	NOUN
cusj-10288	275	28	in	in	ADP
cusj-10288	275	29	huntington	huntington	PROPN
cusj-10288	275	30	's	's	PART
cusj-10288	275	31	disease	disease	NOUN
cusj-10288	275	32	.	.	PUNCT
cusj-10288	276	1	cns	cns	PROPN
cusj-10288	276	2	neuroscience	neuroscience	PROPN
cusj-10288	276	3	&	&	CCONJ
cusj-10288	276	4	therapeutics	therapeutic	NOUN
cusj-10288	276	5	,	,	PUNCT
cusj-10288	276	6	15(1	15(1	NUM
cusj-10288	276	7	)	)	PUNCT
cusj-10288	276	8	,	,	PUNCT
cusj-10288	276	9	1–11	1–11	PROPN
cusj-10288	276	10	.	.	PUNCT
cusj-10288	277	1	https://doi.org/10.1111/j.17555949.2008.00068.x	https://doi.org/10.1111/j.17555949.2008.00068.x	X
cusj-10288	277	2	.	.	PUNCT
cusj-10288	278	1	[	[	X
cusj-10288	278	2	11	11	NUM
cusj-10288	278	3	]	]	X
cusj-10288	278	4	de	de	X
cusj-10288	278	5	la	la	X
cusj-10288	278	6	monte	monte	PROPN
cusj-10288	278	7	,	,	PUNCT
cusj-10288	278	8	s.	s.	PROPN
cusj-10288	278	9	m.	m.	PROPN
cusj-10288	278	10	,	,	PUNCT
cusj-10288	278	11	vonsattel	vonsattel	NOUN
cusj-10288	278	12	,	,	PUNCT
cusj-10288	278	13	j.	j.	PROPN
cusj-10288	278	14	p.	p.	PROPN
cusj-10288	278	15	,	,	PUNCT
cusj-10288	278	16	&	&	CCONJ
cusj-10288	278	17	richardson	richardson	PROPN
cusj-10288	278	18	,	,	PUNCT
cusj-10288	278	19	e.	e.	PROPN
cusj-10288	278	20	p.	p.	PROPN
cusj-10288	278	21	,	,	PUNCT
cusj-10288	278	22	jr	jr	PROPN
cusj-10288	278	23	(	(	PUNCT
cusj-10288	278	24	1988	1988	NUM
cusj-10288	278	25	)	)	PUNCT
cusj-10288	278	26	.	.	PUNCT
cusj-10288	279	1	morphometric	morphometric	ADJ
cusj-10288	279	2	demonstration	demonstration	NOUN
cusj-10288	279	3	of	of	ADP
cusj-10288	279	4	atrophic	atrophic	ADJ
cusj-10288	279	5	changes	change	NOUN
cusj-10288	279	6	in	in	ADP
cusj-10288	279	7	the	the	DET
cusj-10288	279	8	cerebral	cerebral	ADJ
cusj-10288	279	9	cortex	cortex	NOUN
cusj-10288	279	10	,	,	PUNCT
cusj-10288	279	11	white	white	ADJ
cusj-10288	279	12	matter	matter	NOUN
cusj-10288	279	13	,	,	PUNCT
cusj-10288	279	14	and	and	CCONJ
cusj-10288	279	15	neostriatum	neostriatum	NOUN
cusj-10288	279	16	in	in	ADP
cusj-10288	279	17	huntington	huntington	PROPN
cusj-10288	279	18	's	's	PART
cusj-10288	279	19	disease	disease	NOUN
cusj-10288	279	20	.	.	PUNCT
cusj-10288	280	1	journal	journal	PROPN
cusj-10288	280	2	of	of	ADP
cusj-10288	280	3	neuropathology	neuropathology	NOUN
cusj-10288	280	4	and	and	CCONJ
cusj-10288	280	5	experimental	experimental	ADJ
cusj-10288	280	6	neurology	neurology	NOUN
cusj-10288	280	7	,	,	PUNCT
cusj-10288	280	8	47(5	47(5	NOUN
cusj-10288	280	9	)	)	PUNCT
cusj-10288	280	10	,	,	PUNCT
cusj-10288	280	11	516–525	516–525	NUM
cusj-10288	280	12	.	.	PUNCT
cusj-10288	281	1	https://doi.org/10.1097/00005072198809000-00003	https://doi.org/10.1097/00005072198809000-00003	PROPN
cusj-10288	281	2	.	.	PUNCT
cusj-10288	282	1	[	[	X
cusj-10288	282	2	12	12	NUM
cusj-10288	282	3	]	]	X
cusj-10288	282	4	hatters	hatter	NOUN
cusj-10288	282	5	d.	d.	PROPN
cusj-10288	282	6	m.	m.	PROPN
cusj-10288	282	7	(	(	PUNCT
cusj-10288	282	8	2008	2008	NUM
cusj-10288	282	9	)	)	PUNCT
cusj-10288	282	10	.	.	PUNCT
cusj-10288	283	1	protein	protein	NOUN
cusj-10288	283	2	misfolding	misfolde	VERB
cusj-10288	283	3	inside	inside	ADP
cusj-10288	283	4	cells	cell	NOUN
cusj-10288	283	5	:	:	PUNCT
cusj-10288	283	6	the	the	DET
cusj-10288	283	7	case	case	NOUN
cusj-10288	283	8	of	of	ADP
cusj-10288	283	9	huntingtin	huntingtin	NOUN
cusj-10288	283	10	and	and	CCONJ
cusj-10288	283	11	huntington	huntington	PROPN
cusj-10288	283	12	's	's	PART
cusj-10288	283	13	disease	disease	NOUN
cusj-10288	283	14	.	.	PUNCT
cusj-10288	284	1	iubmb	iubmb	NOUN
cusj-10288	284	2	life	life	NOUN
cusj-10288	284	3	,	,	PUNCT
cusj-10288	284	4	60(11	60(11	NUM
cusj-10288	284	5	)	)	PUNCT
cusj-10288	284	6	,	,	PUNCT
cusj-10288	284	7	724	724	NUM
cusj-10288	284	8	–	–	PUNCT
cusj-10288	284	9	728	728	NUM
cusj-10288	284	10	.	.	PUNCT
cusj-10288	285	1	https://doi.org/10.1002/iub.111	https://doi.org/10.1002/iub.111	NOUN
cusj-10288	285	2	.	.	PUNCT
cusj-10288	286	1	[	[	X
cusj-10288	286	2	13	13	NUM
cusj-10288	286	3	]	]	SYM
cusj-10288	286	4	scherzinger	scherzinger	NOUN
cusj-10288	286	5	,	,	PUNCT
cusj-10288	286	6	e.	e.	PROPN
cusj-10288	286	7	,	,	PUNCT
cusj-10288	286	8	sittler	sittler	PROPN
cusj-10288	286	9	,	,	PUNCT
cusj-10288	286	10	a.	a.	PROPN
cusj-10288	286	11	,	,	PUNCT
cusj-10288	286	12	schweiger	schweiger	PROPN
cusj-10288	286	13	,	,	PUNCT
cusj-10288	286	14	k.	k.	PROPN
cusj-10288	286	15	,	,	PUNCT
cusj-10288	286	16	heiser	heiser	PROPN
cusj-10288	286	17	,	,	PUNCT
cusj-10288	286	18	v.	v.	ADV
cusj-10288	286	19	,	,	PUNCT
cusj-10288	286	20	lurz	lurz	PROPN
cusj-10288	286	21	,	,	PUNCT
cusj-10288	286	22	r.	r.	PROPN
cusj-10288	286	23	,	,	PUNCT
cusj-10288	286	24	hasenbank	hasenbank	PROPN
cusj-10288	286	25	,	,	PUNCT
cusj-10288	286	26	r.	r.	PROPN
cusj-10288	286	27	,	,	PUNCT
cusj-10288	286	28	bates	bate	NOUN
cusj-10288	286	29	,	,	PUNCT
cusj-10288	286	30	g.	g.	PROPN
cusj-10288	286	31	p.	p.	PROPN
cusj-10288	286	32	,	,	PUNCT
cusj-10288	286	33	lehrach	lehrach	PROPN
cusj-10288	286	34	,	,	PUNCT
cusj-10288	286	35	h.	h.	PROPN
cusj-10288	286	36	,	,	PUNCT
cusj-10288	286	37	&	&	CCONJ
cusj-10288	286	38	wanker	wanker	PROPN
cusj-10288	286	39	,	,	PUNCT
cusj-10288	286	40	e.	e.	PROPN
cusj-10288	286	41	e.	e.	PROPN
cusj-10288	286	42	(	(	PUNCT
cusj-10288	286	43	1999	1999	NUM
cusj-10288	286	44	)	)	PUNCT
cusj-10288	286	45	.	.	PUNCT
cusj-10288	287	1	self	self	NOUN
cusj-10288	287	2	-	-	PUNCT
cusj-10288	287	3	assembly	assembly	NOUN
cusj-10288	287	4	of	of	ADP
cusj-10288	287	5	polyglutaminecontaining	polyglutaminecontaine	VERB
cusj-10288	287	6	huntingtin	huntingtin	ADJ
cusj-10288	287	7	fragments	fragment	NOUN
cusj-10288	287	8	into	into	ADP
cusj-10288	287	9	amyloidlike	amyloidlike	ADJ
cusj-10288	287	10	fibrils	fibril	NOUN
cusj-10288	287	11	:	:	PUNCT
cusj-10288	287	12	implications	implication	NOUN
cusj-10288	287	13	for	for	ADP
cusj-10288	287	14	huntington	huntington	PROPN
cusj-10288	287	15	's	's	PART
cusj-10288	287	16	disease	disease	NOUN
cusj-10288	287	17	pathology	pathology	NOUN
cusj-10288	287	18	.	.	PUNCT
cusj-10288	288	1	proceedings	proceeding	NOUN
cusj-10288	288	2	of	of	ADP
cusj-10288	288	3	the	the	DET
cusj-10288	288	4	national	national	PROPN
cusj-10288	288	5	academy	academy	PROPN
cusj-10288	288	6	of	of	ADP
cusj-10288	288	7	sciences	sciences	PROPN
cusj-10288	288	8	of	of	ADP
cusj-10288	288	9	the	the	DET
cusj-10288	288	10	united	united	PROPN
cusj-10288	288	11	states	states	PROPN
cusj-10288	288	12	of	of	ADP
cusj-10288	288	13	america	america	PROPN
cusj-10288	288	14	,	,	PUNCT
cusj-10288	288	15	96(8	96(8	NUM
cusj-10288	288	16	)	)	PUNCT
cusj-10288	288	17	,	,	PUNCT
cusj-10288	288	18	4604–4609	4604–4609	NUM
cusj-10288	288	19	.	.	PUNCT
cusj-10288	289	1	https://doi.org/10.1073/pnas.96.8.4604	https://doi.org/10.1073/pnas.96.8.4604	PROPN
cusj-10288	289	2	.	.	PUNCT
cusj-10288	290	1	[	[	X
cusj-10288	290	2	14	14	NUM
cusj-10288	290	3	]	]	X
cusj-10288	290	4	nucifora	nucifora	NOUN
cusj-10288	290	5	,	,	PUNCT
cusj-10288	290	6	f.	f.	PROPN
cusj-10288	290	7	c.	c.	PROPN
cusj-10288	290	8	,	,	PUNCT
cusj-10288	290	9	jr	jr	PROPN
cusj-10288	290	10	,	,	PUNCT
cusj-10288	290	11	sasaki	sasaki	PROPN
cusj-10288	290	12	,	,	PUNCT
cusj-10288	290	13	m.	m.	NOUN
cusj-10288	290	14	,	,	PUNCT
cusj-10288	290	15	peters	peters	PROPN
cusj-10288	290	16	,	,	PUNCT
cusj-10288	290	17	m.	m.	PROPN
cusj-10288	290	18	f.	f.	PROPN
cusj-10288	290	19	,	,	PUNCT
cusj-10288	290	20	huang	huang	PROPN
cusj-10288	290	21	,	,	PUNCT
cusj-10288	290	22	h.	h.	PROPN
cusj-10288	290	23	,	,	PUNCT
cusj-10288	290	24	cooper	cooper	PROPN
cusj-10288	290	25	,	,	PUNCT
cusj-10288	290	26	j.	j.	PROPN
cusj-10288	290	27	k.	k.	PROPN
cusj-10288	290	28	,	,	PUNCT
cusj-10288	290	29	yamada	yamada	PROPN
cusj-10288	290	30	,	,	PUNCT
cusj-10288	290	31	m.	m.	NOUN
cusj-10288	290	32	,	,	PUNCT
cusj-10288	290	33	takahashi	takahashi	PROPN
cusj-10288	290	34	,	,	PUNCT
cusj-10288	290	35	h.	h.	PROPN
cusj-10288	290	36	,	,	PUNCT
cusj-10288	290	37	tsuji	tsuji	PROPN
cusj-10288	290	38	,	,	PUNCT
cusj-10288	290	39	s.	s.	PROPN
cusj-10288	290	40	,	,	PUNCT
cusj-10288	290	41	troncoso	troncoso	PROPN
cusj-10288	290	42	,	,	PUNCT
cusj-10288	290	43	j.	j.	PROPN
cusj-10288	290	44	,	,	PUNCT
cusj-10288	290	45	dawson	dawson	PROPN
cusj-10288	290	46	,	,	PUNCT
cusj-10288	290	47	v.	v.	PROPN
cusj-10288	290	48	l.	l.	PROPN
cusj-10288	290	49	,	,	PUNCT
cusj-10288	290	50	dawson	dawson	PROPN
cusj-10288	290	51	,	,	PUNCT
cusj-10288	290	52	t.	t.	NOUN
cusj-10288	290	53	m.	m.	NOUN
cusj-10288	290	54	,	,	PUNCT
cusj-10288	290	55	&	&	CCONJ
cusj-10288	290	56	ross	ross	PROPN
cusj-10288	290	57	,	,	PUNCT
cusj-10288	290	58	c.	c.	PROPN
cusj-10288	290	59	a.	a.	PROPN
cusj-10288	290	60	(	(	PUNCT
cusj-10288	290	61	2001	2001	NUM
cusj-10288	290	62	)	)	PUNCT
cusj-10288	290	63	.	.	PUNCT
cusj-10288	291	1	interference	interference	NOUN
cusj-10288	291	2	by	by	ADP
cusj-10288	291	3	huntingtin	huntingtin	NOUN
cusj-10288	291	4	and	and	CCONJ
cusj-10288	291	5	atrophin-1	atrophin-1	NUM
cusj-10288	291	6	with	with	ADP
cusj-10288	291	7	cbp	cbp	PROPN
cusj-10288	291	8	-	-	PUNCT
cusj-10288	291	9	mediated	mediate	VERB
cusj-10288	291	10	transcription	transcription	NOUN
cusj-10288	291	11	leading	lead	VERB
cusj-10288	291	12	to	to	ADP
cusj-10288	291	13	cellular	cellular	ADJ
cusj-10288	291	14	toxicity	toxicity	NOUN
cusj-10288	291	15	.	.	PUNCT
cusj-10288	292	1	science	science	NOUN
cusj-10288	292	2	(	(	PUNCT
cusj-10288	292	3	new	new	PROPN
cusj-10288	292	4	york	york	PROPN
cusj-10288	292	5	,	,	PUNCT
cusj-10288	292	6	n.y	n.y	PROPN
cusj-10288	292	7	.	.	PROPN
cusj-10288	292	8	)	)	PUNCT
cusj-10288	292	9	,	,	PUNCT
cusj-10288	292	10	291(5512	291(5512	NOUN
cusj-10288	292	11	)	)	PUNCT
cusj-10288	292	12	,	,	PUNCT
cusj-10288	292	13	2423–2428	2423–2428	NUM
cusj-10288	292	14	.	.	PUNCT
cusj-10288	293	1	https://doi.org/10.1126/science.1056784	https://doi.org/10.1126/science.1056784	NOUN
cusj-10288	293	2	.	.	PUNCT
cusj-10288	294	1	[	[	X
cusj-10288	294	2	15	15	NUM
cusj-10288	294	3	]	]	X
cusj-10288	294	4	imarisio	imarisio	NOUN
cusj-10288	294	5	,	,	PUNCT
cusj-10288	294	6	s.	s.	PROPN
cusj-10288	294	7	,	,	PUNCT
cusj-10288	294	8	carmichael	carmichael	PROPN
cusj-10288	294	9	,	,	PUNCT
cusj-10288	294	10	j.	j.	PROPN
cusj-10288	294	11	,	,	PUNCT
cusj-10288	294	12	korolchuk	korolchuk	NOUN
cusj-10288	294	13	,	,	PUNCT
cusj-10288	294	14	v.	v.	PROPN
cusj-10288	294	15	,	,	PUNCT
cusj-10288	294	16	chen	chen	PROPN
cusj-10288	294	17	,	,	PUNCT
cusj-10288	294	18	c.	c.	PROPN
cusj-10288	294	19	w.	w.	PROPN
cusj-10288	294	20	,	,	PUNCT
cusj-10288	294	21	saiki	saiki	PROPN
cusj-10288	294	22	,	,	PUNCT
cusj-10288	294	23	s.	s.	PROPN
cusj-10288	294	24	,	,	PUNCT
cusj-10288	294	25	rose	rise	VERB
cusj-10288	294	26	,	,	PUNCT
cusj-10288	294	27	c.	c.	NOUN
cusj-10288	294	28	,	,	PUNCT
cusj-10288	294	29	krishna	krishna	PROPN
cusj-10288	294	30	,	,	PUNCT
cusj-10288	294	31	g.	g.	PROPN
cusj-10288	294	32	,	,	PUNCT
cusj-10288	294	33	davies	davy	NOUN
cusj-10288	294	34	,	,	PUNCT
cusj-10288	294	35	j.	j.	PROPN
cusj-10288	294	36	e.	e.	PROPN
cusj-10288	294	37	,	,	PUNCT
cusj-10288	294	38	ttofi	ttofi	PROPN
cusj-10288	294	39	,	,	PUNCT
cusj-10288	294	40	e.	e.	PROPN
cusj-10288	294	41	,	,	PUNCT
cusj-10288	294	42	underwood	underwood	PROPN
cusj-10288	294	43	,	,	PUNCT
cusj-10288	294	44	b.	b.	PROPN
cusj-10288	294	45	r.	r.	PROPN
cusj-10288	294	46	,	,	PUNCT
cusj-10288	294	47	&	&	CCONJ
cusj-10288	294	48	rubinsztein	rubinsztein	PROPN
cusj-10288	294	49	,	,	PUNCT
cusj-10288	294	50	d.	d.	PROPN
cusj-10288	294	51	c.	c.	PROPN
cusj-10288	294	52	(	(	PUNCT
cusj-10288	294	53	2008	2008	NUM
cusj-10288	294	54	)	)	PUNCT
cusj-10288	294	55	.	.	PUNCT
cusj-10288	295	1	huntington	huntington	PROPN
cusj-10288	295	2	's	's	PART
cusj-10288	295	3	disease	disease	NOUN
cusj-10288	295	4	:	:	PUNCT
cusj-10288	295	5	from	from	ADP
cusj-10288	295	6	pathology	pathology	NOUN
cusj-10288	295	7	and	and	CCONJ
cusj-10288	295	8	genetics	genetic	NOUN
cusj-10288	295	9	to	to	ADP
cusj-10288	295	10	potential	potential	ADJ
cusj-10288	295	11	therapies	therapy	NOUN
cusj-10288	295	12	.	.	PUNCT
cusj-10288	296	1	the	the	DET
cusj-10288	296	2	biochemical	biochemical	ADJ
cusj-10288	296	3	journal	journal	NOUN
cusj-10288	296	4	,	,	PUNCT
cusj-10288	296	5	412(2	412(2	NUM
cusj-10288	296	6	)	)	PUNCT
cusj-10288	296	7	,	,	PUNCT
cusj-10288	296	8	191–209	191–209	NUM
cusj-10288	296	9	.	.	PUNCT
cusj-10288	296	10	https://doi.org/10.1042/bj20071619	https://doi.org/10.1042/bj20071619	X
cusj-10288	296	11	.	.	PUNCT
cusj-10288	297	1	[	[	X
cusj-10288	297	2	16	16	NUM
cusj-10288	297	3	]	]	PUNCT
cusj-10288	297	4	baxendale	baxendale	NOUN
cusj-10288	297	5	,	,	PUNCT
cusj-10288	297	6	s.	s.	PROPN
cusj-10288	297	7	,	,	PUNCT
cusj-10288	297	8	abdulla	abdulla	PROPN
cusj-10288	297	9	,	,	PUNCT
cusj-10288	297	10	s.	s.	PROPN
cusj-10288	297	11	,	,	PUNCT
cusj-10288	297	12	elgar	elgar	PROPN
cusj-10288	297	13	,	,	PUNCT
cusj-10288	297	14	g.	g.	PROPN
cusj-10288	297	15	,	,	PUNCT
cusj-10288	297	16	buck	buck	PROPN
cusj-10288	297	17	,	,	PUNCT
cusj-10288	297	18	d.	d.	PROPN
cusj-10288	297	19	,	,	PUNCT
cusj-10288	297	20	berks	berks	PROPN
cusj-10288	297	21	,	,	PUNCT
cusj-10288	297	22	m.	m.	NOUN
cusj-10288	297	23	,	,	PUNCT
cusj-10288	297	24	micklem	micklem	NOUN
cusj-10288	297	25	,	,	PUNCT
cusj-10288	297	26	g.	g.	NOUN
cusj-10288	297	27	,	,	PUNCT
cusj-10288	297	28	durbin	durbin	PROPN
cusj-10288	297	29	,	,	PUNCT
cusj-10288	297	30	r.	r.	PROPN
cusj-10288	297	31	,	,	PUNCT
cusj-10288	297	32	bates	bate	NOUN
cusj-10288	297	33	,	,	PUNCT
cusj-10288	297	34	g.	g.	PROPN
cusj-10288	297	35	,	,	PUNCT
cusj-10288	297	36	brenner	brenner	PROPN
cusj-10288	297	37	,	,	PUNCT
cusj-10288	297	38	s.	s.	PROPN
cusj-10288	297	39	,	,	PUNCT
cusj-10288	297	40	&	&	CCONJ
cusj-10288	297	41	beck	beck	PROPN
cusj-10288	297	42	,	,	PUNCT
cusj-10288	297	43	s.	s.	PROPN
cusj-10288	297	44	(	(	PUNCT
cusj-10288	297	45	1995	1995	NUM
cusj-10288	297	46	)	)	PUNCT
cusj-10288	297	47	.	.	PUNCT
cusj-10288	298	1	comparative	comparative	ADJ
cusj-10288	298	2	sequence	sequence	NOUN
cusj-10288	298	3	analysis	analysis	NOUN
cusj-10288	298	4	of	of	ADP
cusj-10288	298	5	the	the	DET
cusj-10288	298	6	human	human	ADJ
cusj-10288	298	7	and	and	CCONJ
cusj-10288	298	8	pufferfish	pufferfish	PROPN
cusj-10288	298	9	huntington	huntington	PROPN
cusj-10288	298	10	's	's	PART
cusj-10288	298	11	disease	disease	NOUN
cusj-10288	298	12	genes	gene	NOUN
cusj-10288	298	13	.	.	PUNCT
cusj-10288	299	1	nature	nature	NOUN
cusj-10288	299	2	genetics	genetic	NOUN
cusj-10288	299	3	,	,	PUNCT
cusj-10288	299	4	10(1	10(1	NUM
cusj-10288	299	5	)	)	PUNCT
cusj-10288	299	6	,	,	PUNCT
cusj-10288	299	7	67–76	67–76	NOUN
cusj-10288	299	8	.	.	PUNCT
cusj-10288	300	1	https://doi.org/10.1038/ng0595-67	https://doi.org/10.1038/ng0595-67	X
cusj-10288	300	2	.	.	PUNCT
cusj-10288	301	1	columbia	columbia	PROPN
cusj-10288	301	2	undergraduate	undergraduate	PROPN
cusj-10288	301	3	science	science	PROPN
cusj-10288	301	4	journal	journal	PROPN
cusj-10288	301	5	vol	vol	NOUN
cusj-10288	301	6	.	.	PROPN
cusj-10288	301	7	17	17	NUM
cusj-10288	301	8	,	,	PUNCT
cusj-10288	301	9	2023	2023	NUM
cusj-10288	301	10	datta	datta	NOUN
cusj-10288	301	11	28	28	NUM
cusj-10288	302	1	[	[	X
cusj-10288	302	2	17	17	NUM
cusj-10288	302	3	]	]	SYM
cusj-10288	302	4	li	li	PROPN
cusj-10288	302	5	,	,	PUNCT
cusj-10288	302	6	w.	w.	PROPN
cusj-10288	302	7	,	,	PUNCT
cusj-10288	302	8	serpell	serpell	PROPN
cusj-10288	302	9	,	,	PUNCT
cusj-10288	302	10	l.	l.	PROPN
cusj-10288	302	11	c.	c.	PROPN
cusj-10288	302	12	,	,	PUNCT
cusj-10288	302	13	carter	carter	PROPN
cusj-10288	302	14	,	,	PUNCT
cusj-10288	302	15	w.	w.	PROPN
cusj-10288	302	16	j.	j.	PROPN
cusj-10288	302	17	,	,	PUNCT
cusj-10288	302	18	rubinsztein	rubinsztein	PROPN
cusj-10288	302	19	,	,	PUNCT
cusj-10288	302	20	d.	d.	PROPN
cusj-10288	302	21	c.	c.	PROPN
cusj-10288	302	22	,	,	PUNCT
cusj-10288	302	23	&	&	CCONJ
cusj-10288	302	24	huntington	huntington	PROPN
cusj-10288	302	25	,	,	PUNCT
cusj-10288	302	26	j.	j.	PROPN
cusj-10288	302	27	a.	a.	PROPN
cusj-10288	302	28	(	(	PUNCT
cusj-10288	302	29	2006	2006	NUM
cusj-10288	302	30	)	)	PUNCT
cusj-10288	302	31	.	.	PUNCT
cusj-10288	303	1	expression	expression	NOUN
cusj-10288	303	2	and	and	CCONJ
cusj-10288	303	3	characterization	characterization	NOUN
cusj-10288	303	4	of	of	ADP
cusj-10288	303	5	full	full	ADJ
cusj-10288	303	6	-	-	PUNCT
cusj-10288	303	7	length	length	NOUN
cusj-10288	303	8	human	human	ADJ
cusj-10288	303	9	huntingtin	huntingtin	NOUN
cusj-10288	303	10	,	,	PUNCT
cusj-10288	303	11	an	an	DET
cusj-10288	303	12	elongated	elongate	VERB
cusj-10288	303	13	heat	heat	NOUN
cusj-10288	303	14	repeat	repeat	NOUN
cusj-10288	303	15	protein	protein	NOUN
cusj-10288	303	16	.	.	PUNCT
cusj-10288	304	1	the	the	DET
cusj-10288	304	2	journal	journal	NOUN
cusj-10288	304	3	of	of	ADP
cusj-10288	304	4	biological	biological	ADJ
cusj-10288	304	5	chemistry	chemistry	NOUN
cusj-10288	304	6	,	,	PUNCT
cusj-10288	304	7	281(23	281(23	NOUN
cusj-10288	304	8	)	)	PUNCT
cusj-10288	304	9	,	,	PUNCT
cusj-10288	304	10	15916–15922	15916–15922	NUM
cusj-10288	304	11	.	.	PUNCT
cusj-10288	304	12	https://doi.org/10.1074/jbc.m511007200	https://doi.org/10.1074/jbc.m511007200	X
cusj-10288	304	13	.	.	PUNCT
cusj-10288	305	1	[	[	X
cusj-10288	305	2	18	18	NUM
cusj-10288	305	3	]	]	X
cusj-10288	305	4	macdonald	macdonald	PROPN
cusj-10288	305	5	m.	m.	PROPN
cusj-10288	305	6	e.	e.	PROPN
cusj-10288	305	7	(	(	PUNCT
cusj-10288	305	8	2003	2003	NUM
cusj-10288	305	9	)	)	PUNCT
cusj-10288	305	10	.	.	PUNCT
cusj-10288	306	1	huntingtin	huntingtin	PROPN
cusj-10288	306	2	:	:	PUNCT
cusj-10288	306	3	alive	alive	ADJ
cusj-10288	306	4	and	and	CCONJ
cusj-10288	306	5	well	well	ADV
cusj-10288	306	6	and	and	CCONJ
cusj-10288	306	7	working	work	VERB
cusj-10288	306	8	in	in	ADP
cusj-10288	306	9	middle	middle	ADJ
cusj-10288	306	10	management	management	NOUN
cusj-10288	306	11	.	.	PUNCT
cusj-10288	307	1	science	science	NOUN
cusj-10288	307	2	's	's	PART
cusj-10288	307	3	stke	stke	NOUN
cusj-10288	307	4	:	:	PUNCT
cusj-10288	307	5	signal	signal	VERB
cusj-10288	307	6	transduction	transduction	NOUN
cusj-10288	307	7	knowledge	knowledge	NOUN
cusj-10288	307	8	environment	environment	NOUN
cusj-10288	307	9	,	,	PUNCT
cusj-10288	307	10	2003(207	2003(207	NOUN
cusj-10288	307	11	)	)	PUNCT
cusj-10288	307	12	,	,	PUNCT
cusj-10288	307	13	pe48	pe48	PROPN
cusj-10288	307	14	.	.	PUNCT
cusj-10288	307	15	https://doi.org/10.1126/stke.2003.207.pe48	https://doi.org/10.1126/stke.2003.207.pe48	PROPN
cusj-10288	307	16	.	.	PUNCT
cusj-10288	308	1	[	[	X
cusj-10288	308	2	19	19	NUM
cusj-10288	308	3	]	]	X
cusj-10288	308	4	myers	myers	PROPN
cusj-10288	308	5	rh	rh	PROPN
cusj-10288	308	6	,	,	PUNCT
cusj-10288	308	7	marans	marans	PROPN
cusj-10288	308	8	k	k	PROPN
cusj-10288	308	9	,	,	PUNCT
cusj-10288	308	10	macdonald	macdonald	PROPN
cusj-10288	308	11	me	me	PROPN
cusj-10288	308	12	.	.	PUNCT
cusj-10288	309	1	huntington	huntington	PROPN
cusj-10288	309	2	’s	’s	PART
cusj-10288	309	3	disease	disease	NOUN
cusj-10288	309	4	.	.	PUNCT
cusj-10288	310	1	in	in	ADP
cusj-10288	310	2	:	:	PUNCT
cusj-10288	310	3	genetic	genetic	ADJ
cusj-10288	310	4	instabilities	instability	NOUN
cusj-10288	310	5	and	and	CCONJ
cusj-10288	310	6	hereditary	hereditary	ADJ
cusj-10288	310	7	neurological	neurological	ADJ
cusj-10288	310	8	diseases	disease	NOUN
cusj-10288	310	9	(	(	PUNCT
cusj-10288	310	10	warren	warren	PROPN
cusj-10288	310	11	st	st	PROPN
cusj-10288	310	12	,	,	PUNCT
cusj-10288	310	13	wells	wells	PROPN
cusj-10288	310	14	rt	rt	PROPN
cusj-10288	310	15	,	,	PUNCT
cusj-10288	310	16	eds	ed	NOUN
cusj-10288	310	17	)	)	PUNCT
cusj-10288	310	18	,	,	PUNCT
cusj-10288	310	19	pp	pp	ADP
cusj-10288	310	20	301–323	301–323	NUM
cusj-10288	310	21	.	.	PUNCT
cusj-10288	310	22	new	new	PROPN
cusj-10288	310	23	york	york	PROPN
cusj-10288	310	24	:	:	PUNCT
cusj-10288	310	25	academic	academic	ADJ
cusj-10288	310	26	press	press	NOUN
cusj-10288	310	27	,	,	PUNCT
cusj-10288	310	28	1998	1998	NUM
cusj-10288	310	29	.	.	PUNCT
cusj-10288	311	1	[	[	X
cusj-10288	311	2	20	20	NUM
cusj-10288	311	3	]	]	SYM
cusj-10288	311	4	gusella	gusella	PROPN
cusj-10288	311	5	,	,	PUNCT
cusj-10288	311	6	j.	j.	PROPN
cusj-10288	311	7	f.	f.	PROPN
cusj-10288	311	8	,	,	PUNCT
cusj-10288	311	9	wexler	wexler	PROPN
cusj-10288	311	10	,	,	PUNCT
cusj-10288	311	11	n.	n.	PROPN
cusj-10288	311	12	s.	s.	PROPN
cusj-10288	311	13	,	,	PUNCT
cusj-10288	311	14	conneally	conneally	ADV
cusj-10288	311	15	,	,	PUNCT
cusj-10288	311	16	p.	p.	NOUN
cusj-10288	311	17	m.	m.	NOUN
cusj-10288	311	18	,	,	PUNCT
cusj-10288	311	19	naylor	naylor	PROPN
cusj-10288	311	20	,	,	PUNCT
cusj-10288	311	21	s.	s.	PROPN
cusj-10288	311	22	l.	l.	PROPN
cusj-10288	311	23	,	,	PUNCT
cusj-10288	311	24	anderson	anderson	PROPN
cusj-10288	311	25	,	,	PUNCT
cusj-10288	311	26	m.	m.	NOUN
cusj-10288	311	27	a.	a.	PROPN
cusj-10288	311	28	,	,	PUNCT
cusj-10288	311	29	tanzi	tanzi	PROPN
cusj-10288	311	30	,	,	PUNCT
cusj-10288	311	31	r.	r.	PROPN
cusj-10288	311	32	e.	e.	PROPN
cusj-10288	311	33	,	,	PUNCT
cusj-10288	311	34	watkins	watkins	PROPN
cusj-10288	311	35	,	,	PUNCT
cusj-10288	311	36	p.	p.	PROPN
cusj-10288	311	37	c.	c.	PROPN
cusj-10288	311	38	,	,	PUNCT
cusj-10288	311	39	ottina	ottina	PROPN
cusj-10288	311	40	,	,	PUNCT
cusj-10288	311	41	k.	k.	PROPN
cusj-10288	311	42	,	,	PUNCT
cusj-10288	311	43	wallace	wallace	PROPN
cusj-10288	311	44	,	,	PUNCT
cusj-10288	311	45	m.	m.	NOUN
cusj-10288	311	46	r.	r.	PROPN
cusj-10288	311	47	,	,	PUNCT
cusj-10288	311	48	&	&	CCONJ
cusj-10288	311	49	sakaguchi	sakaguchi	PROPN
cusj-10288	311	50	,	,	PUNCT
cusj-10288	311	51	a.	a.	NOUN
cusj-10288	311	52	y.	y.	PROPN
cusj-10288	311	53	(	(	PUNCT
cusj-10288	311	54	1983	1983	NUM
cusj-10288	311	55	)	)	PUNCT
cusj-10288	311	56	.	.	PUNCT
cusj-10288	312	1	a	a	DET
cusj-10288	312	2	polymorphic	polymorphic	ADJ
cusj-10288	312	3	dna	dna	NOUN
cusj-10288	312	4	marker	marker	NOUN
cusj-10288	312	5	genetically	genetically	ADV
cusj-10288	312	6	linked	link	VERB
cusj-10288	312	7	to	to	ADP
cusj-10288	312	8	huntington	huntington	PROPN
cusj-10288	312	9	's	's	PART
cusj-10288	312	10	disease	disease	NOUN
cusj-10288	312	11	.	.	PUNCT
cusj-10288	313	1	nature	nature	NOUN
cusj-10288	313	2	,	,	PUNCT
cusj-10288	313	3	306(5940	306(5940	NUM
cusj-10288	313	4	)	)	PUNCT
cusj-10288	313	5	,	,	PUNCT
cusj-10288	313	6	234–238	234–238	NUM
cusj-10288	313	7	.	.	PUNCT
cusj-10288	313	8	https://doi.org/10.1038/306234a0	https://doi.org/10.1038/306234a0	PROPN
cusj-10288	313	9	.	.	PUNCT
cusj-10288	314	1	[	[	X
cusj-10288	314	2	21	21	NUM
cusj-10288	314	3	]	]	X
cusj-10288	314	4	myers	myers	PROPN
cusj-10288	314	5	r.	r.	PROPN
cusj-10288	314	6	h.	h.	PROPN
cusj-10288	314	7	(	(	PUNCT
cusj-10288	314	8	2004	2004	NUM
cusj-10288	314	9	)	)	PUNCT
cusj-10288	314	10	.	.	PUNCT
cusj-10288	315	1	huntington	huntington	PROPN
cusj-10288	315	2	's	's	PART
cusj-10288	315	3	disease	disease	NOUN
cusj-10288	315	4	genetics	genetic	NOUN
cusj-10288	315	5	.	.	PUNCT
cusj-10288	316	1	neurorx	neurorx	PROPN
cusj-10288	316	2	:	:	PUNCT
cusj-10288	316	3	the	the	DET
cusj-10288	316	4	journal	journal	NOUN
cusj-10288	316	5	of	of	ADP
cusj-10288	316	6	the	the	DET
cusj-10288	316	7	american	american	ADJ
cusj-10288	316	8	society	society	NOUN
cusj-10288	316	9	for	for	ADP
cusj-10288	316	10	experimental	experimental	ADJ
cusj-10288	316	11	neurotherapeutics	neurotherapeutic	NOUN
cusj-10288	316	12	,	,	PUNCT
cusj-10288	316	13	1(2	1(2	NUM
cusj-10288	316	14	)	)	PUNCT
cusj-10288	316	15	,	,	PUNCT
cusj-10288	316	16	255–262	255–262	NUM
cusj-10288	316	17	.	.	PUNCT
cusj-10288	317	1	https://doi.org/10.1602/neurorx.1.2.255	https://doi.org/10.1602/neurorx.1.2.255	PROPN
cusj-10288	317	2	.	.	PUNCT
cusj-10288	318	1	[	[	X
cusj-10288	318	2	22	22	NUM
cusj-10288	318	3	]	]	SYM
cusj-10288	318	4	duyao	duyao	NOUN
cusj-10288	318	5	,	,	PUNCT
cusj-10288	318	6	m.	m.	NOUN
cusj-10288	318	7	,	,	PUNCT
cusj-10288	318	8	ambrose	ambrose	PROPN
cusj-10288	318	9	,	,	PUNCT
cusj-10288	318	10	c.	c.	PROPN
cusj-10288	318	11	,	,	PUNCT
cusj-10288	318	12	myers	myers	PROPN
cusj-10288	318	13	,	,	PUNCT
cusj-10288	318	14	r.	r.	PROPN
cusj-10288	318	15	,	,	PUNCT
cusj-10288	318	16	novelletto	novelletto	NOUN
cusj-10288	318	17	,	,	PUNCT
cusj-10288	318	18	a.	a.	NOUN
cusj-10288	318	19	,	,	PUNCT
cusj-10288	318	20	persichetti	persichetti	PROPN
cusj-10288	318	21	,	,	PUNCT
cusj-10288	318	22	f.	f.	PROPN
cusj-10288	318	23	,	,	PUNCT
cusj-10288	318	24	frontali	frontali	VERB
cusj-10288	318	25	,	,	PUNCT
cusj-10288	318	26	m.	m.	NOUN
cusj-10288	318	27	,	,	PUNCT
cusj-10288	318	28	folstein	folstein	ADJ
cusj-10288	318	29	,	,	PUNCT
cusj-10288	318	30	s.	s.	PROPN
cusj-10288	318	31	,	,	PUNCT
cusj-10288	318	32	ross	ross	PROPN
cusj-10288	318	33	,	,	PUNCT
cusj-10288	318	34	c.	c.	PROPN
cusj-10288	318	35	,	,	PUNCT
cusj-10288	318	36	franz	franz	PROPN
cusj-10288	318	37	,	,	PUNCT
cusj-10288	318	38	m.	m.	NOUN
cusj-10288	318	39	,	,	PUNCT
cusj-10288	318	40	&	&	CCONJ
cusj-10288	318	41	abbott	abbott	PROPN
cusj-10288	318	42	,	,	PUNCT
cusj-10288	318	43	m.	m.	NOUN
cusj-10288	318	44	(	(	PUNCT
cusj-10288	318	45	1993	1993	NUM
cusj-10288	318	46	)	)	PUNCT
cusj-10288	318	47	.	.	PUNCT
cusj-10288	319	1	trinucleotide	trinucleotide	INTJ
cusj-10288	319	2	repeat	repeat	NOUN
cusj-10288	319	3	length	length	NOUN
cusj-10288	319	4	instability	instability	NOUN
cusj-10288	319	5	and	and	CCONJ
cusj-10288	319	6	age	age	NOUN
cusj-10288	319	7	of	of	ADP
cusj-10288	319	8	onset	onset	NOUN
cusj-10288	319	9	in	in	ADP
cusj-10288	319	10	huntington	huntington	PROPN
cusj-10288	319	11	's	's	PART
cusj-10288	319	12	disease	disease	NOUN
cusj-10288	319	13	.	.	PUNCT
cusj-10288	320	1	nature	nature	NOUN
cusj-10288	320	2	genetics	genetic	NOUN
cusj-10288	320	3	,	,	PUNCT
cusj-10288	320	4	4(4	4(4	NUM
cusj-10288	320	5	)	)	PUNCT
cusj-10288	320	6	,	,	PUNCT
cusj-10288	320	7	387–392	387–392	NUM
cusj-10288	320	8	.	.	PUNCT
cusj-10288	320	9	https://doi.org/10.1038/ng0893-387	https://doi.org/10.1038/ng0893-387	NOUN
cusj-10288	320	10	.	.	PUNCT
cusj-10288	321	1	[	[	X
cusj-10288	321	2	23	23	NUM
cusj-10288	321	3	]	]	PUNCT
cusj-10288	321	4	tartari	tartari	NOUN
cusj-10288	321	5	,	,	PUNCT
cusj-10288	321	6	m.	m.	NOUN
cusj-10288	321	7	,	,	PUNCT
cusj-10288	321	8	gissi	gissi	NOUN
cusj-10288	321	9	,	,	PUNCT
cusj-10288	321	10	c.	c.	PROPN
cusj-10288	321	11	,	,	PUNCT
cusj-10288	321	12	lo	lo	PROPN
cusj-10288	321	13	sardo	sardo	PROPN
cusj-10288	321	14	,	,	PUNCT
cusj-10288	321	15	v.	v.	ADV
cusj-10288	321	16	,	,	PUNCT
cusj-10288	321	17	zuccato	zuccato	PROPN
cusj-10288	321	18	,	,	PUNCT
cusj-10288	321	19	c.	c.	PROPN
cusj-10288	321	20	,	,	PUNCT
cusj-10288	321	21	picardi	picardi	PROPN
cusj-10288	321	22	,	,	PUNCT
cusj-10288	321	23	e.	e.	PROPN
cusj-10288	321	24	,	,	PUNCT
cusj-10288	321	25	pesole	pesole	NOUN
cusj-10288	321	26	,	,	PUNCT
cusj-10288	321	27	g.	g.	PROPN
cusj-10288	321	28	,	,	PUNCT
cusj-10288	321	29	&	&	CCONJ
cusj-10288	321	30	cattaneo	cattaneo	PROPN
cusj-10288	321	31	,	,	PUNCT
cusj-10288	321	32	e.	e.	PROPN
cusj-10288	321	33	(	(	PUNCT
cusj-10288	321	34	2008	2008	NUM
cusj-10288	321	35	)	)	PUNCT
cusj-10288	321	36	.	.	PUNCT
cusj-10288	322	1	phylogenetic	phylogenetic	ADJ
cusj-10288	322	2	comparison	comparison	NOUN
cusj-10288	322	3	of	of	ADP
cusj-10288	322	4	huntingtin	huntingtin	ADJ
cusj-10288	322	5	homologues	homologue	NOUN
cusj-10288	322	6	reveals	reveal	VERB
cusj-10288	322	7	the	the	DET
cusj-10288	322	8	appearance	appearance	NOUN
cusj-10288	322	9	of	of	ADP
cusj-10288	322	10	a	a	DET
cusj-10288	322	11	primitive	primitive	ADJ
cusj-10288	322	12	polyq	polyq	NOUN
cusj-10288	322	13	in	in	ADP
cusj-10288	322	14	sea	sea	NOUN
cusj-10288	322	15	urchin	urchin	NOUN
cusj-10288	322	16	.	.	PUNCT
cusj-10288	323	1	molecular	molecular	ADJ
cusj-10288	323	2	biology	biology	NOUN
cusj-10288	323	3	and	and	CCONJ
cusj-10288	323	4	evolution	evolution	NOUN
cusj-10288	323	5	,	,	PUNCT
cusj-10288	323	6	25(2	25(2	NUM
cusj-10288	323	7	)	)	PUNCT
cusj-10288	323	8	,	,	PUNCT
cusj-10288	323	9	330	330	NUM
cusj-10288	323	10	–	–	PUNCT
cusj-10288	323	11	338	338	NUM
cusj-10288	323	12	.	.	PUNCT
cusj-10288	324	1	https://doi.org/10.1093/molbev/msm258	https://doi.org/10.1093/molbev/msm258	NOUN
cusj-10288	324	2	.	.	PUNCT
cusj-10288	325	1	[	[	X
cusj-10288	325	2	24	24	NUM
cusj-10288	325	3	]	]	X
cusj-10288	325	4	takano	takano	PROPN
cusj-10288	325	5	,	,	PUNCT
cusj-10288	325	6	h.	h.	PROPN
cusj-10288	325	7	,	,	PUNCT
cusj-10288	325	8	&	&	CCONJ
cusj-10288	325	9	gusella	gusella	PROPN
cusj-10288	325	10	,	,	PUNCT
cusj-10288	325	11	j.	j.	PROPN
cusj-10288	325	12	f.	f.	PROPN
cusj-10288	325	13	(	(	PUNCT
cusj-10288	325	14	2002	2002	NUM
cusj-10288	325	15	)	)	PUNCT
cusj-10288	325	16	.	.	PUNCT
cusj-10288	326	1	the	the	DET
cusj-10288	326	2	predominantly	predominantly	ADV
cusj-10288	326	3	heat	heat	NOUN
cusj-10288	326	4	-	-	PUNCT
cusj-10288	326	5	like	like	ADJ
cusj-10288	326	6	motif	motif	NOUN
cusj-10288	326	7	structure	structure	NOUN
cusj-10288	326	8	of	of	ADP
cusj-10288	326	9	huntingtin	huntingtin	NOUN
cusj-10288	326	10	and	and	CCONJ
cusj-10288	326	11	its	its	PRON
cusj-10288	326	12	association	association	NOUN
cusj-10288	326	13	and	and	CCONJ
cusj-10288	326	14	coincident	coincident	ADJ
cusj-10288	326	15	nuclear	nuclear	ADJ
cusj-10288	326	16	entry	entry	NOUN
cusj-10288	326	17	with	with	ADP
cusj-10288	326	18	dorsal	dorsal	NOUN
cusj-10288	326	19	,	,	PUNCT
cusj-10288	326	20	an	an	DET
cusj-10288	326	21	nfkb	nfkb	PROPN
cusj-10288	326	22	/	/	SYM
cusj-10288	326	23	rel	rel	NOUN
cusj-10288	326	24	/	/	SYM
cusj-10288	326	25	dorsal	dorsal	NOUN
cusj-10288	326	26	family	family	NOUN
cusj-10288	326	27	transcription	transcription	NOUN
cusj-10288	326	28	factor	factor	NOUN
cusj-10288	326	29	.	.	PUNCT
cusj-10288	327	1	bmc	bmc	ADJ
cusj-10288	327	2	neuroscience	neuroscience	NOUN
cusj-10288	327	3	,	,	PUNCT
cusj-10288	327	4	3	3	NUM
cusj-10288	327	5	,	,	PUNCT
cusj-10288	327	6	15	15	NUM
cusj-10288	327	7	.	.	PUNCT
cusj-10288	328	1	https://doi.org/10.1186/1471-2202-3-15	https://doi.org/10.1186/1471-2202-3-15	NOUN
cusj-10288	328	2	.	.	PUNCT
cusj-10288	329	1	[	[	X
cusj-10288	329	2	25	25	NUM
cusj-10288	329	3	]	]	PUNCT
cusj-10288	329	4	chook	chook	NOUN
cusj-10288	329	5	,	,	PUNCT
cusj-10288	329	6	y.	y.	PROPN
cusj-10288	329	7	m.	m.	PROPN
cusj-10288	329	8	,	,	PUNCT
cusj-10288	329	9	&	&	CCONJ
cusj-10288	329	10	blobel	blobel	NOUN
cusj-10288	329	11	,	,	PUNCT
cusj-10288	329	12	g.	g.	PROPN
cusj-10288	329	13	(	(	PUNCT
cusj-10288	329	14	1999	1999	NUM
cusj-10288	329	15	)	)	PUNCT
cusj-10288	329	16	.	.	PUNCT
cusj-10288	330	1	structure	structure	NOUN
cusj-10288	330	2	of	of	ADP
cusj-10288	330	3	the	the	DET
cusj-10288	330	4	nuclear	nuclear	ADJ
cusj-10288	330	5	transport	transport	NOUN
cusj-10288	330	6	complex	complex	ADJ
cusj-10288	330	7	karyopherin	karyopherin	NOUN
cusj-10288	330	8	-	-	PUNCT
cusj-10288	330	9	beta2	beta2	NOUN
cusj-10288	330	10	-	-	PUNCT
cusj-10288	330	11	ran	ran	NOUN
cusj-10288	330	12	x	x	PROPN
cusj-10288	330	13	gppnhp	gppnhp	PROPN
cusj-10288	330	14	.	.	PUNCT
cusj-10288	331	1	nature	nature	NOUN
cusj-10288	331	2	,	,	PUNCT
cusj-10288	331	3	399(6733	399(6733	NUM
cusj-10288	331	4	)	)	PUNCT
cusj-10288	331	5	,	,	PUNCT
cusj-10288	331	6	230–237	230–237	NUM
cusj-10288	331	7	.	.	PUNCT
cusj-10288	332	1	https://doi.org/10.1038/20375	https://doi.org/10.1038/20375	X
cusj-10288	332	2	.	.	PUNCT
cusj-10288	333	1	[	[	X
cusj-10288	333	2	26	26	NUM
cusj-10288	333	3	]	]	PUNCT
cusj-10288	333	4	grinthal	grinthal	NOUN
cusj-10288	333	5	,	,	PUNCT
cusj-10288	333	6	a.	a.	NOUN
cusj-10288	333	7	,	,	PUNCT
cusj-10288	333	8	adamovic	adamovic	ADJ
cusj-10288	333	9	,	,	PUNCT
cusj-10288	333	10	i.	i.	NOUN
cusj-10288	333	11	,	,	PUNCT
cusj-10288	333	12	weiner	weiner	NOUN
cusj-10288	333	13	,	,	PUNCT
cusj-10288	333	14	b.	b.	PROPN
cusj-10288	333	15	,	,	PUNCT
cusj-10288	333	16	karplus	karplus	PROPN
cusj-10288	333	17	,	,	PUNCT
cusj-10288	333	18	m.	m.	NOUN
cusj-10288	333	19	,	,	PUNCT
cusj-10288	333	20	&	&	CCONJ
cusj-10288	333	21	kleckner	kleckner	PROPN
cusj-10288	333	22	,	,	PUNCT
cusj-10288	333	23	n.	n.	PROPN
cusj-10288	333	24	(	(	PUNCT
cusj-10288	333	25	2010	2010	NUM
cusj-10288	333	26	)	)	PUNCT
cusj-10288	333	27	.	.	PUNCT
cusj-10288	334	1	pr65	pr65	PROPN
cusj-10288	334	2	,	,	PUNCT
cusj-10288	334	3	the	the	DET
cusj-10288	334	4	heat	heat	NOUN
cusj-10288	334	5	-	-	PUNCT
cusj-10288	334	6	repeat	repeat	NOUN
cusj-10288	334	7	scaffold	scaffold	NOUN
cusj-10288	334	8	of	of	ADP
cusj-10288	334	9	phosphatase	phosphatase	NOUN
cusj-10288	334	10	pp2a	pp2a	PROPN
cusj-10288	334	11	,	,	PUNCT
cusj-10288	334	12	is	be	AUX
cusj-10288	334	13	an	an	DET
cusj-10288	334	14	elastic	elastic	ADJ
cusj-10288	334	15	connector	connector	NOUN
cusj-10288	334	16	that	that	PRON
cusj-10288	334	17	links	link	VERB
cusj-10288	334	18	force	force	NOUN
cusj-10288	334	19	and	and	CCONJ
cusj-10288	334	20	catalysis	catalysis	NOUN
cusj-10288	334	21	.	.	PUNCT
cusj-10288	335	1	proceedings	proceeding	NOUN
cusj-10288	335	2	of	of	ADP
cusj-10288	335	3	the	the	DET
cusj-10288	335	4	national	national	PROPN
cusj-10288	335	5	academy	academy	PROPN
cusj-10288	335	6	of	of	ADP
cusj-10288	335	7	sciences	sciences	PROPN
cusj-10288	335	8	of	of	ADP
cusj-10288	335	9	the	the	DET
cusj-10288	335	10	united	united	PROPN
cusj-10288	335	11	states	states	PROPN
cusj-10288	335	12	of	of	ADP
cusj-10288	335	13	america	america	PROPN
cusj-10288	335	14	,	,	PUNCT
cusj-10288	335	15	107(6	107(6	NUM
cusj-10288	335	16	)	)	PUNCT
cusj-10288	335	17	,	,	PUNCT
cusj-10288	335	18	2467–2472	2467–2472	NUM
cusj-10288	335	19	.	.	PUNCT
cusj-10288	336	1	https://doi.org/10.1073/pnas.0914073107	https://doi.org/10.1073/pnas.0914073107	NOUN
cusj-10288	336	2	.	.	PUNCT
cusj-10288	337	1	[	[	X
cusj-10288	337	2	27	27	NUM
cusj-10288	337	3	]	]	PUNCT
cusj-10288	337	4	tartari	tartari	NOUN
cusj-10288	337	5	,	,	PUNCT
cusj-10288	337	6	m.	m.	NOUN
cusj-10288	337	7	,	,	PUNCT
cusj-10288	337	8	gissi	gissi	NOUN
cusj-10288	337	9	,	,	PUNCT
cusj-10288	337	10	c.	c.	PROPN
cusj-10288	337	11	,	,	PUNCT
cusj-10288	337	12	lo	lo	PROPN
cusj-10288	337	13	sardo	sardo	PROPN
cusj-10288	337	14	,	,	PUNCT
cusj-10288	337	15	v.	v.	ADV
cusj-10288	337	16	,	,	PUNCT
cusj-10288	337	17	zuccato	zuccato	PROPN
cusj-10288	337	18	,	,	PUNCT
cusj-10288	337	19	c.	c.	PROPN
cusj-10288	337	20	,	,	PUNCT
cusj-10288	337	21	picardi	picardi	PROPN
cusj-10288	337	22	,	,	PUNCT
cusj-10288	337	23	e.	e.	PROPN
cusj-10288	337	24	,	,	PUNCT
cusj-10288	337	25	pesole	pesole	NOUN
cusj-10288	337	26	,	,	PUNCT
cusj-10288	337	27	g.	g.	PROPN
cusj-10288	337	28	,	,	PUNCT
cusj-10288	337	29	&	&	CCONJ
cusj-10288	337	30	cattaneo	cattaneo	PROPN
cusj-10288	337	31	,	,	PUNCT
cusj-10288	337	32	e.	e.	PROPN
cusj-10288	337	33	(	(	PUNCT
cusj-10288	337	34	2008	2008	NUM
cusj-10288	337	35	)	)	PUNCT
cusj-10288	337	36	.	.	PUNCT
cusj-10288	338	1	phylogenetic	phylogenetic	ADJ
cusj-10288	338	2	comparison	comparison	NOUN
cusj-10288	338	3	of	of	ADP
cusj-10288	338	4	huntingtin	huntingtin	ADJ
cusj-10288	338	5	homologues	homologue	NOUN
cusj-10288	338	6	reveals	reveal	VERB
cusj-10288	338	7	the	the	DET
cusj-10288	338	8	appearance	appearance	NOUN
cusj-10288	338	9	of	of	ADP
cusj-10288	338	10	a	a	DET
cusj-10288	338	11	primitive	primitive	ADJ
cusj-10288	338	12	polyq	polyq	NOUN
cusj-10288	338	13	in	in	ADP
cusj-10288	338	14	sea	sea	NOUN
cusj-10288	338	15	urchin	urchin	NOUN
cusj-10288	338	16	.	.	PUNCT
cusj-10288	339	1	molecular	molecular	ADJ
cusj-10288	339	2	biology	biology	NOUN
cusj-10288	339	3	and	and	CCONJ
cusj-10288	339	4	evolution	evolution	NOUN
cusj-10288	339	5	,	,	PUNCT
cusj-10288	339	6	25(2	25(2	NUM
cusj-10288	339	7	)	)	PUNCT
cusj-10288	339	8	,	,	PUNCT
cusj-10288	339	9	330	330	NUM
cusj-10288	339	10	–	–	PUNCT
cusj-10288	339	11	338	338	NUM
cusj-10288	339	12	.	.	PUNCT
cusj-10288	340	1	https://doi.org/10.1093/molbev/msm258	https://doi.org/10.1093/molbev/msm258	NOUN
cusj-10288	340	2	.	.	PUNCT
cusj-10288	341	1	[	[	X
cusj-10288	341	2	28	28	NUM
cusj-10288	341	3	]	]	SYM
cusj-10288	341	4	li	li	PROPN
cusj-10288	341	5	,	,	PUNCT
cusj-10288	341	6	s.	s.	PROPN
cusj-10288	341	7	h.	h.	PROPN
cusj-10288	341	8	,	,	PUNCT
cusj-10288	341	9	&	&	CCONJ
cusj-10288	341	10	li	li	PROPN
cusj-10288	341	11	,	,	PUNCT
cusj-10288	341	12	x.	x.	PROPN
cusj-10288	341	13	j.	j.	PROPN
cusj-10288	341	14	(	(	PUNCT
cusj-10288	341	15	2004	2004	NUM
cusj-10288	341	16	)	)	PUNCT
cusj-10288	341	17	.	.	PUNCT
cusj-10288	342	1	huntingtinprotein	huntingtinprotein	ADJ
cusj-10288	342	2	interactions	interaction	NOUN
cusj-10288	342	3	and	and	CCONJ
cusj-10288	342	4	the	the	DET
cusj-10288	342	5	pathogenesis	pathogenesis	NOUN
cusj-10288	342	6	of	of	ADP
cusj-10288	342	7	huntington	huntington	PROPN
cusj-10288	342	8	's	's	PART
cusj-10288	342	9	disease	disease	NOUN
cusj-10288	342	10	.	.	PUNCT
cusj-10288	343	1	trends	trend	NOUN
cusj-10288	343	2	in	in	ADP
cusj-10288	343	3	genetics	genetics	PROPN
cusj-10288	343	4	:	:	PUNCT
cusj-10288	343	5	tig	tig	X
cusj-10288	343	6	,	,	PUNCT
cusj-10288	343	7	20(3	20(3	NOUN
cusj-10288	343	8	)	)	PUNCT
cusj-10288	343	9	,	,	PUNCT
cusj-10288	343	10	146–154	146–154	NUM
cusj-10288	343	11	.	.	PUNCT
cusj-10288	344	1	https://doi.org/10.1016/j.tig.2004.01.008	https://doi.org/10.1016/j.tig.2004.01.008	NOUN
cusj-10288	344	2	.	.	PUNCT
cusj-10288	345	1	[	[	X
cusj-10288	345	2	29	29	NUM
cusj-10288	345	3	]	]	SYM
cusj-10288	345	4	clabough	clabough	NOUN
cusj-10288	345	5	,	,	PUNCT
cusj-10288	345	6	e.	e.	PROPN
cusj-10288	345	7	b.	b.	PROPN
cusj-10288	345	8	,	,	PUNCT
cusj-10288	345	9	&	&	CCONJ
cusj-10288	345	10	zeitlin	zeitlin	PROPN
cusj-10288	345	11	,	,	PUNCT
cusj-10288	345	12	s.	s.	PROPN
cusj-10288	345	13	o.	o.	PROPN
cusj-10288	345	14	(	(	PUNCT
cusj-10288	345	15	2006	2006	NUM
cusj-10288	345	16	)	)	PUNCT
cusj-10288	345	17	.	.	PUNCT
cusj-10288	346	1	deletion	deletion	NOUN
cusj-10288	346	2	of	of	ADP
cusj-10288	346	3	the	the	DET
cusj-10288	346	4	triplet	triplet	NOUN
cusj-10288	346	5	repeat	repeat	NOUN
cusj-10288	346	6	encoding	encode	VERB
cusj-10288	346	7	polyglutamine	polyglutamine	NOUN
cusj-10288	346	8	within	within	ADP
cusj-10288	346	9	the	the	DET
cusj-10288	346	10	mouse	mouse	PROPN
cusj-10288	346	11	huntington	huntington	PROPN
cusj-10288	346	12	's	's	PART
cusj-10288	346	13	disease	disease	NOUN
cusj-10288	346	14	gene	gene	NOUN
cusj-10288	346	15	results	result	NOUN
cusj-10288	346	16	in	in	ADP
cusj-10288	346	17	subtle	subtle	ADJ
cusj-10288	346	18	behaviorcolumbia	behaviorcolumbia	NOUN
cusj-10288	346	19	undergraduate	undergraduate	NOUN
cusj-10288	346	20	science	science	PROPN
cusj-10288	346	21	journal	journal	PROPN
cusj-10288	346	22	vol	vol	NOUN
cusj-10288	346	23	.	.	PROPN
cusj-10288	346	24	17	17	NUM
cusj-10288	346	25	,	,	PUNCT
cusj-10288	346	26	2023	2023	NUM
cusj-10288	346	27	datta	datta	NOUN
cusj-10288	346	28	29	29	NUM
cusj-10288	346	29	al	al	PROPN
cusj-10288	346	30	/	/	SYM
cusj-10288	346	31	motor	motor	NOUN
cusj-10288	346	32	phenotypes	phenotype	NOUN
cusj-10288	346	33	in	in	ADP
cusj-10288	346	34	vivo	vivo	NOUN
cusj-10288	346	35	and	and	CCONJ
cusj-10288	346	36	elevated	elevated	ADJ
cusj-10288	346	37	levels	level	NOUN
cusj-10288	346	38	of	of	ADP
cusj-10288	346	39	atp	atp	PROPN
cusj-10288	346	40	with	with	ADP
cusj-10288	346	41	cellular	cellular	ADJ
cusj-10288	346	42	senescence	senescence	NOUN
cusj-10288	346	43	in	in	ADP
cusj-10288	346	44	vitro	vitro	X
cusj-10288	346	45	.	.	PUNCT
cusj-10288	347	1	human	human	ADJ
cusj-10288	347	2	molecular	molecular	ADJ
cusj-10288	347	3	genetics	genetic	NOUN
cusj-10288	347	4	,	,	PUNCT
cusj-10288	347	5	15(4	15(4	NUM
cusj-10288	347	6	)	)	PUNCT
cusj-10288	347	7	,	,	PUNCT
cusj-10288	347	8	607	607	NUM
cusj-10288	347	9	–	–	PUNCT
cusj-10288	347	10	623	623	NUM
cusj-10288	347	11	.	.	PUNCT
cusj-10288	348	1	https://doi.org/10.1093/hmg/ddi477	https://doi.org/10.1093/hmg/ddi477	NOUN
cusj-10288	348	2	.	.	PUNCT
cusj-10288	349	1	[	[	X
cusj-10288	349	2	30	30	NUM
cusj-10288	349	3	]	]	PUNCT
cusj-10288	349	4	fiumara	fiumara	PROPN
cusj-10288	349	5	,	,	PUNCT
cusj-10288	349	6	f.	f.	PROPN
cusj-10288	349	7	,	,	PUNCT
cusj-10288	349	8	fioriti	fioriti	PROPN
cusj-10288	349	9	,	,	PUNCT
cusj-10288	349	10	l.	l.	PROPN
cusj-10288	349	11	,	,	PUNCT
cusj-10288	349	12	kandel	kandel	PROPN
cusj-10288	349	13	,	,	PUNCT
cusj-10288	349	14	e.	e.	PROPN
cusj-10288	349	15	r.	r.	PROPN
cusj-10288	349	16	,	,	PUNCT
cusj-10288	349	17	&	&	CCONJ
cusj-10288	349	18	hendrickson	hendrickson	PROPN
cusj-10288	349	19	,	,	PUNCT
cusj-10288	349	20	w.	w.	PROPN
cusj-10288	349	21	a.	a.	PROPN
cusj-10288	349	22	(	(	PUNCT
cusj-10288	349	23	2010	2010	NUM
cusj-10288	349	24	)	)	PUNCT
cusj-10288	349	25	.	.	PUNCT
cusj-10288	350	1	essential	essential	ADJ
cusj-10288	350	2	role	role	NOUN
cusj-10288	350	3	of	of	ADP
cusj-10288	350	4	coiled	coil	VERB
cusj-10288	350	5	coils	coil	NOUN
cusj-10288	350	6	for	for	ADP
cusj-10288	350	7	aggregation	aggregation	NOUN
cusj-10288	350	8	and	and	CCONJ
cusj-10288	350	9	activity	activity	NOUN
cusj-10288	350	10	of	of	ADP
cusj-10288	350	11	q	q	NOUN
cusj-10288	350	12	/	/	SYM
cusj-10288	350	13	n	n	CCONJ
cusj-10288	350	14	-	-	PUNCT
cusj-10288	350	15	rich	rich	ADJ
cusj-10288	350	16	prions	prion	NOUN
cusj-10288	350	17	and	and	CCONJ
cusj-10288	350	18	polyq	polyq	NOUN
cusj-10288	350	19	proteins	protein	NOUN
cusj-10288	350	20	.	.	PUNCT
cusj-10288	351	1	cell	cell	NOUN
cusj-10288	351	2	,	,	PUNCT
cusj-10288	351	3	143(7	143(7	NUM
cusj-10288	351	4	)	)	PUNCT
cusj-10288	351	5	,	,	PUNCT
cusj-10288	351	6	1121–1135	1121–1135	NUM
cusj-10288	351	7	.	.	PUNCT
cusj-10288	352	1	https://doi.org/10.1016/j.cell.2010.11.042	https://doi.org/10.1016/j.cell.2010.11.042	NOUN
cusj-10288	352	2	.	.	PUNCT
cusj-10288	353	1	[	[	X
cusj-10288	353	2	31	31	NUM
cusj-10288	353	3	]	]	X
cusj-10288	353	4	ignatova	ignatova	PROPN
cusj-10288	353	5	,	,	PUNCT
cusj-10288	353	6	z.	z.	PROPN
cusj-10288	353	7	,	,	PUNCT
cusj-10288	353	8	&	&	CCONJ
cusj-10288	353	9	gierasch	gierasch	PROPN
cusj-10288	353	10	,	,	PUNCT
cusj-10288	353	11	l.	l.	PROPN
cusj-10288	353	12	m.	m.	PROPN
cusj-10288	353	13	(	(	PUNCT
cusj-10288	353	14	2006	2006	NUM
cusj-10288	353	15	)	)	PUNCT
cusj-10288	353	16	.	.	PUNCT
cusj-10288	354	1	inhibition	inhibition	NOUN
cusj-10288	354	2	of	of	ADP
cusj-10288	354	3	protein	protein	NOUN
cusj-10288	354	4	aggregation	aggregation	NOUN
cusj-10288	354	5	in	in	ADP
cusj-10288	354	6	vitro	vitro	X
cusj-10288	354	7	and	and	CCONJ
cusj-10288	354	8	in	in	ADP
cusj-10288	354	9	vivo	vivo	NOUN
cusj-10288	354	10	by	by	ADP
cusj-10288	354	11	a	a	DET
cusj-10288	354	12	natural	natural	ADJ
cusj-10288	354	13	osmoprotectant	osmoprotectant	NOUN
cusj-10288	354	14	.	.	PUNCT
cusj-10288	355	1	proceedings	proceeding	NOUN
cusj-10288	355	2	of	of	ADP
cusj-10288	355	3	the	the	DET
cusj-10288	355	4	national	national	PROPN
cusj-10288	355	5	academy	academy	PROPN
cusj-10288	355	6	of	of	ADP
cusj-10288	355	7	sciences	sciences	PROPN
cusj-10288	355	8	of	of	ADP
cusj-10288	355	9	the	the	DET
cusj-10288	355	10	united	united	PROPN
cusj-10288	355	11	states	states	PROPN
cusj-10288	355	12	of	of	ADP
cusj-10288	355	13	america	america	PROPN
cusj-10288	355	14	,	,	PUNCT
cusj-10288	355	15	103(36	103(36	NUM
cusj-10288	355	16	)	)	PUNCT
cusj-10288	355	17	,	,	PUNCT
cusj-10288	355	18	13357–13361	13357–13361	NUM
cusj-10288	355	19	.	.	PUNCT
cusj-10288	355	20	https://doi.org/10.1073/pnas.0603772103	https://doi.org/10.1073/pnas.0603772103	NOUN
cusj-10288	355	21	.	.	PUNCT
cusj-10288	356	1	[	[	X
cusj-10288	356	2	32	32	NUM
cusj-10288	356	3	]	]	X
cusj-10288	356	4	qin	qin	PROPN
cusj-10288	356	5	,	,	PUNCT
cusj-10288	356	6	z.	z.	PROPN
cusj-10288	356	7	h.	h.	PROPN
cusj-10288	356	8	,	,	PUNCT
cusj-10288	356	9	wang	wang	PROPN
cusj-10288	356	10	,	,	PUNCT
cusj-10288	356	11	y.	y.	PROPN
cusj-10288	356	12	,	,	PUNCT
cusj-10288	356	13	sapp	sapp	PROPN
cusj-10288	356	14	,	,	PUNCT
cusj-10288	356	15	e.	e.	PROPN
cusj-10288	356	16	,	,	PUNCT
cusj-10288	356	17	cuiffo	cuiffo	PROPN
cusj-10288	356	18	,	,	PUNCT
cusj-10288	356	19	b.	b.	PROPN
cusj-10288	356	20	,	,	PUNCT
cusj-10288	356	21	wanker	wanker	PROPN
cusj-10288	356	22	,	,	PUNCT
cusj-10288	356	23	e.	e.	PROPN
cusj-10288	356	24	,	,	PUNCT
cusj-10288	356	25	hayden	hayden	PROPN
cusj-10288	356	26	,	,	PUNCT
cusj-10288	356	27	m.	m.	PROPN
cusj-10288	356	28	r.	r.	PROPN
cusj-10288	356	29	,	,	PUNCT
cusj-10288	356	30	kegel	kegel	PROPN
cusj-10288	356	31	,	,	PUNCT
cusj-10288	356	32	k.	k.	PROPN
cusj-10288	356	33	b.	b.	PROPN
cusj-10288	356	34	,	,	PUNCT
cusj-10288	356	35	aronin	aronin	PROPN
cusj-10288	356	36	,	,	PUNCT
cusj-10288	356	37	n.	n.	NOUN
cusj-10288	356	38	,	,	PUNCT
cusj-10288	356	39	&	&	CCONJ
cusj-10288	356	40	difiglia	difiglia	PROPN
cusj-10288	356	41	,	,	PUNCT
cusj-10288	356	42	m.	m.	NOUN
cusj-10288	356	43	(	(	PUNCT
cusj-10288	356	44	2004	2004	NUM
cusj-10288	356	45	)	)	PUNCT
cusj-10288	356	46	.	.	PUNCT
cusj-10288	357	1	huntingtin	huntingtin	PROPN
cusj-10288	357	2	bodies	body	NOUN
cusj-10288	357	3	sequester	sequester	VERB
cusj-10288	357	4	vesicle	vesicle	NOUN
cusj-10288	357	5	-	-	PUNCT
cusj-10288	357	6	associated	associate	VERB
cusj-10288	357	7	proteins	protein	NOUN
cusj-10288	357	8	by	by	ADP
cusj-10288	357	9	a	a	DET
cusj-10288	357	10	polyproline	polyproline	ADJ
cusj-10288	357	11	-	-	PUNCT
cusj-10288	357	12	dependent	dependent	ADJ
cusj-10288	357	13	interaction	interaction	NOUN
cusj-10288	357	14	.	.	PUNCT
cusj-10288	358	1	the	the	DET
cusj-10288	358	2	journal	journal	NOUN
cusj-10288	358	3	of	of	ADP
cusj-10288	358	4	neuroscience	neuroscience	NOUN
cusj-10288	358	5	:	:	PUNCT
cusj-10288	358	6	the	the	DET
cusj-10288	358	7	official	official	ADJ
cusj-10288	358	8	journal	journal	NOUN
cusj-10288	358	9	of	of	ADP
cusj-10288	358	10	the	the	DET
cusj-10288	358	11	society	society	NOUN
cusj-10288	358	12	for	for	ADP
cusj-10288	358	13	neuroscience	neuroscience	NOUN
cusj-10288	358	14	,	,	PUNCT
cusj-10288	358	15	24(1	24(1	NUM
cusj-10288	358	16	)	)	PUNCT
cusj-10288	358	17	,	,	PUNCT
cusj-10288	358	18	269	269	NUM
cusj-10288	358	19	–	–	PUNCT
cusj-10288	358	20	281	281	NUM
cusj-10288	358	21	.	.	PUNCT
cusj-10288	359	1	https://doi.org/10.1523/jneurosci.140903.2004	https://doi.org/10.1523/jneurosci.140903.2004	NOUN
cusj-10288	359	2	.	.	PUNCT
cusj-10288	360	1	[	[	X
cusj-10288	360	2	33	33	NUM
cusj-10288	360	3	]	]	PUNCT
cusj-10288	360	4	atwal	atwal	NOUN
cusj-10288	360	5	,	,	PUNCT
cusj-10288	360	6	r.	r.	PROPN
cusj-10288	360	7	s.	s.	PROPN
cusj-10288	360	8	,	,	PUNCT
cusj-10288	360	9	xia	xia	PROPN
cusj-10288	360	10	,	,	PUNCT
cusj-10288	360	11	j.	j.	PROPN
cusj-10288	360	12	,	,	PUNCT
cusj-10288	360	13	pinchev	pinchev	PROPN
cusj-10288	360	14	,	,	PUNCT
cusj-10288	360	15	d.	d.	PROPN
cusj-10288	360	16	,	,	PUNCT
cusj-10288	360	17	taylor	taylor	PROPN
cusj-10288	360	18	,	,	PUNCT
cusj-10288	360	19	j.	j.	PROPN
cusj-10288	360	20	,	,	PUNCT
cusj-10288	360	21	epand	epand	PROPN
cusj-10288	360	22	,	,	PUNCT
cusj-10288	360	23	r.	r.	PROPN
cusj-10288	360	24	m.	m.	PROPN
cusj-10288	360	25	,	,	PUNCT
cusj-10288	360	26	&	&	CCONJ
cusj-10288	360	27	truant	truant	PROPN
cusj-10288	360	28	,	,	PUNCT
cusj-10288	360	29	r.	r.	PROPN
cusj-10288	360	30	(	(	PUNCT
cusj-10288	360	31	2007	2007	NUM
cusj-10288	360	32	)	)	PUNCT
cusj-10288	360	33	.	.	PUNCT
cusj-10288	361	1	huntingtin	huntingtin	PROPN
cusj-10288	361	2	has	have	VERB
cusj-10288	361	3	a	a	DET
cusj-10288	361	4	membrane	membrane	NOUN
cusj-10288	361	5	association	association	NOUN
cusj-10288	361	6	signal	signal	NOUN
cusj-10288	361	7	that	that	PRON
cusj-10288	361	8	can	can	AUX
cusj-10288	361	9	modulate	modulate	VERB
cusj-10288	361	10	huntingtin	huntingtin	NOUN
cusj-10288	361	11	aggregation	aggregation	NOUN
cusj-10288	361	12	,	,	PUNCT
cusj-10288	361	13	nuclear	nuclear	ADJ
cusj-10288	361	14	entry	entry	NOUN
cusj-10288	361	15	and	and	CCONJ
cusj-10288	361	16	toxicity	toxicity	NOUN
cusj-10288	361	17	.	.	PUNCT
cusj-10288	362	1	human	human	ADJ
cusj-10288	362	2	molecular	molecular	ADJ
cusj-10288	362	3	genetics	genetic	NOUN
cusj-10288	362	4	,	,	PUNCT
cusj-10288	362	5	16(21	16(21	NUM
cusj-10288	362	6	)	)	PUNCT
cusj-10288	362	7	,	,	PUNCT
cusj-10288	362	8	2600–2615	2600–2615	NUM
cusj-10288	362	9	.	.	PUNCT
cusj-10288	363	1	https://doi.org/10.1093/hmg/ddm217	https://doi.org/10.1093/hmg/ddm217	NOUN
cusj-10288	363	2	.	.	PUNCT
cusj-10288	364	1	[	[	X
cusj-10288	364	2	34	34	NUM
cusj-10288	364	3	]	]	PUNCT
cusj-10288	364	4	cornett	cornett	NOUN
cusj-10288	364	5	,	,	PUNCT
cusj-10288	364	6	j.	j.	PROPN
cusj-10288	364	7	,	,	PUNCT
cusj-10288	364	8	cao	cao	PROPN
cusj-10288	364	9	,	,	PUNCT
cusj-10288	364	10	f.	f.	PROPN
cusj-10288	364	11	,	,	PUNCT
cusj-10288	364	12	wang	wang	PROPN
cusj-10288	364	13	,	,	PUNCT
cusj-10288	364	14	c.	c.	PROPN
cusj-10288	364	15	e.	e.	PROPN
cusj-10288	364	16	,	,	PUNCT
cusj-10288	364	17	ross	ross	PROPN
cusj-10288	364	18	,	,	PUNCT
cusj-10288	364	19	c.	c.	PROPN
cusj-10288	364	20	a.	a.	PROPN
cusj-10288	364	21	,	,	PUNCT
cusj-10288	364	22	bates	bate	NOUN
cusj-10288	364	23	,	,	PUNCT
cusj-10288	364	24	g.	g.	PROPN
cusj-10288	364	25	p.	p.	PROPN
cusj-10288	364	26	,	,	PUNCT
cusj-10288	364	27	li	li	PROPN
cusj-10288	364	28	,	,	PUNCT
cusj-10288	364	29	s.	s.	PROPN
cusj-10288	364	30	h.	h.	PROPN
cusj-10288	364	31	,	,	PUNCT
cusj-10288	364	32	&	&	CCONJ
cusj-10288	364	33	li	li	PROPN
cusj-10288	364	34	,	,	PUNCT
cusj-10288	364	35	x.	x.	PROPN
cusj-10288	364	36	j.	j.	PROPN
cusj-10288	364	37	(	(	PUNCT
cusj-10288	364	38	2005	2005	NUM
cusj-10288	364	39	)	)	PUNCT
cusj-10288	364	40	.	.	PUNCT
cusj-10288	365	1	polyglutamine	polyglutamine	NOUN
cusj-10288	365	2	expansion	expansion	NOUN
cusj-10288	365	3	of	of	ADP
cusj-10288	365	4	huntingtin	huntingtin	NOUN
cusj-10288	365	5	impairs	impair	VERB
cusj-10288	365	6	its	its	PRON
cusj-10288	365	7	nuclear	nuclear	ADJ
cusj-10288	365	8	export	export	NOUN
cusj-10288	365	9	.	.	PUNCT
cusj-10288	366	1	nature	nature	NOUN
cusj-10288	366	2	genetics	genetics	PROPN
cusj-10288	366	3	,	,	PUNCT
cusj-10288	366	4	37(2	37(2	NOUN
cusj-10288	366	5	)	)	PUNCT
cusj-10288	366	6	,	,	PUNCT
cusj-10288	366	7	198–204	198–204	NUM
cusj-10288	366	8	.	.	PUNCT
cusj-10288	367	1	https://doi.org/10.1038/ng1503	https://doi.org/10.1038/ng1503	NOUN
cusj-10288	367	2	.	.	PUNCT
cusj-10288	368	1	[	[	X
cusj-10288	368	2	35	35	NUM
cusj-10288	368	3	]	]	X
cusj-10288	368	4	gafni	gafni	NOUN
cusj-10288	368	5	,	,	PUNCT
cusj-10288	368	6	j.	j.	PROPN
cusj-10288	368	7	,	,	PUNCT
cusj-10288	368	8	hermel	hermel	PROPN
cusj-10288	368	9	,	,	PUNCT
cusj-10288	368	10	e.	e.	PROPN
cusj-10288	368	11	,	,	PUNCT
cusj-10288	368	12	young	young	PROPN
cusj-10288	368	13	,	,	PUNCT
cusj-10288	368	14	j.	j.	PROPN
cusj-10288	368	15	e.	e.	PROPN
cusj-10288	368	16	,	,	PUNCT
cusj-10288	368	17	wellington	wellington	PROPN
cusj-10288	368	18	,	,	PUNCT
cusj-10288	368	19	c.	c.	PROPN
cusj-10288	368	20	l.	l.	PROPN
cusj-10288	368	21	,	,	PUNCT
cusj-10288	368	22	hayden	hayden	PROPN
cusj-10288	368	23	,	,	PUNCT
cusj-10288	368	24	m.	m.	PROPN
cusj-10288	368	25	r.	r.	PROPN
cusj-10288	368	26	,	,	PUNCT
cusj-10288	368	27	&	&	CCONJ
cusj-10288	368	28	ellerby	ellerby	PROPN
cusj-10288	368	29	,	,	PUNCT
cusj-10288	368	30	l.	l.	PROPN
cusj-10288	368	31	m.	m.	PROPN
cusj-10288	368	32	(	(	PUNCT
cusj-10288	368	33	2004	2004	NUM
cusj-10288	368	34	)	)	PUNCT
cusj-10288	368	35	.	.	PUNCT
cusj-10288	369	1	inhibition	inhibition	NOUN
cusj-10288	369	2	of	of	ADP
cusj-10288	369	3	calpain	calpain	NOUN
cusj-10288	369	4	cleavage	cleavage	NOUN
cusj-10288	369	5	of	of	ADP
cusj-10288	369	6	huntingtin	huntingtin	NOUN
cusj-10288	369	7	reduces	reduce	VERB
cusj-10288	369	8	toxicity	toxicity	NOUN
cusj-10288	369	9	:	:	PUNCT
cusj-10288	369	10	accumulation	accumulation	NOUN
cusj-10288	369	11	of	of	ADP
cusj-10288	369	12	calpain	calpain	NOUN
cusj-10288	369	13	/	/	SYM
cusj-10288	369	14	caspase	caspase	NOUN
cusj-10288	369	15	fragments	fragment	VERB
cusj-10288	369	16	in	in	ADP
cusj-10288	369	17	the	the	DET
cusj-10288	369	18	nucleus	nucleus	NOUN
cusj-10288	369	19	.	.	PUNCT
cusj-10288	370	1	the	the	DET
cusj-10288	370	2	journal	journal	NOUN
cusj-10288	370	3	of	of	ADP
cusj-10288	370	4	biological	biological	ADJ
cusj-10288	370	5	chemistry	chemistry	NOUN
cusj-10288	370	6	,	,	PUNCT
cusj-10288	370	7	279(19	279(19	NUM
cusj-10288	370	8	)	)	PUNCT
cusj-10288	370	9	,	,	PUNCT
cusj-10288	370	10	20211–20220	20211–20220	NUM
cusj-10288	370	11	.	.	PUNCT
cusj-10288	370	12	https://doi.org/10.1074/jbc.m401267200	https://doi.org/10.1074/jbc.m401267200	NOUN
cusj-10288	370	13	.	.	PUNCT
cusj-10288	371	1	[	[	X
cusj-10288	371	2	36	36	NUM
cusj-10288	371	3	]	]	X
cusj-10288	371	4	mende	mende	PROPN
cusj-10288	371	5	-	-	PUNCT
cusj-10288	371	6	mueller	mueller	PROPN
cusj-10288	371	7	,	,	PUNCT
cusj-10288	371	8	l.	l.	PROPN
cusj-10288	371	9	m.	m.	PROPN
cusj-10288	371	10	,	,	PUNCT
cusj-10288	371	11	toneff	toneff	NOUN
cusj-10288	371	12	,	,	PUNCT
cusj-10288	371	13	t.	t.	PROPN
cusj-10288	371	14	,	,	PUNCT
cusj-10288	371	15	hwang	hwang	PROPN
cusj-10288	371	16	,	,	PUNCT
cusj-10288	371	17	s.	s.	PROPN
cusj-10288	371	18	r.	r.	PROPN
cusj-10288	371	19	,	,	PUNCT
cusj-10288	371	20	chesselet	chesselet	NOUN
cusj-10288	371	21	,	,	PUNCT
cusj-10288	371	22	m.	m.	NOUN
cusj-10288	371	23	f.	f.	PROPN
cusj-10288	371	24	,	,	PUNCT
cusj-10288	371	25	&	&	CCONJ
cusj-10288	371	26	hook	hook	NOUN
cusj-10288	371	27	,	,	PUNCT
cusj-10288	371	28	v.	v.	PROPN
cusj-10288	371	29	y.	y.	PROPN
cusj-10288	371	30	(	(	PUNCT
cusj-10288	371	31	2001	2001	NUM
cusj-10288	371	32	)	)	PUNCT
cusj-10288	371	33	.	.	PUNCT
cusj-10288	372	1	tissue	tissue	NOUN
cusj-10288	372	2	-	-	PUNCT
cusj-10288	372	3	specific	specific	ADJ
cusj-10288	372	4	proteolysis	proteolysis	NOUN
cusj-10288	372	5	of	of	ADP
cusj-10288	372	6	huntingtin	huntingtin	NOUN
cusj-10288	372	7	(	(	PUNCT
cusj-10288	372	8	htt	htt	NOUN
cusj-10288	372	9	)	)	PUNCT
cusj-10288	372	10	in	in	ADP
cusj-10288	372	11	human	human	ADJ
cusj-10288	372	12	brain	brain	NOUN
cusj-10288	372	13	:	:	PUNCT
cusj-10288	372	14	evidence	evidence	NOUN
cusj-10288	372	15	of	of	ADP
cusj-10288	372	16	enhanced	enhanced	ADJ
cusj-10288	372	17	levels	level	NOUN
cusj-10288	372	18	of	of	ADP
cusj-10288	372	19	nand	nand	NOUN
cusj-10288	372	20	c	c	NOUN
cusj-10288	372	21	-	-	PUNCT
cusj-10288	372	22	terminal	terminal	ADJ
cusj-10288	372	23	htt	htt	NOUN
cusj-10288	372	24	fragments	fragment	NOUN
cusj-10288	372	25	in	in	ADP
cusj-10288	372	26	huntington	huntington	PROPN
cusj-10288	372	27	's	's	PART
cusj-10288	372	28	disease	disease	NOUN
cusj-10288	372	29	striatum	striatum	NOUN
cusj-10288	372	30	.	.	PUNCT
cusj-10288	373	1	the	the	DET
cusj-10288	373	2	journal	journal	NOUN
cusj-10288	373	3	of	of	ADP
cusj-10288	373	4	neuroscience	neuroscience	NOUN
cusj-10288	373	5	:	:	PUNCT
cusj-10288	373	6	the	the	DET
cusj-10288	373	7	official	official	ADJ
cusj-10288	373	8	journal	journal	NOUN
cusj-10288	373	9	of	of	ADP
cusj-10288	373	10	the	the	DET
cusj-10288	373	11	society	society	NOUN
cusj-10288	373	12	for	for	ADP
cusj-10288	373	13	neuroscience	neuroscience	NOUN
cusj-10288	373	14	,	,	PUNCT
cusj-10288	373	15	21(6	21(6	NUM
cusj-10288	373	16	)	)	PUNCT
cusj-10288	373	17	,	,	PUNCT
cusj-10288	373	18	1830–1837	1830–1837	NUM
cusj-10288	373	19	.	.	PUNCT
cusj-10288	374	1	https://doi.org/10.1523/jneurosci.21-0601830.2001	https://doi.org/10.1523/jneurosci.21-0601830.2001	PROPN
cusj-10288	374	2	.	.	PUNCT
cusj-10288	375	1	[	[	X
cusj-10288	375	2	37	37	NUM
cusj-10288	375	3	]	]	X
cusj-10288	375	4	kim	kim	PROPN
cusj-10288	375	5	,	,	PUNCT
cusj-10288	375	6	y.	y.	PROPN
cusj-10288	375	7	j.	j.	PROPN
cusj-10288	375	8	,	,	PUNCT
cusj-10288	375	9	sapp	sapp	PROPN
cusj-10288	375	10	,	,	PUNCT
cusj-10288	375	11	e.	e.	PROPN
cusj-10288	375	12	,	,	PUNCT
cusj-10288	375	13	cuiffo	cuiffo	PROPN
cusj-10288	375	14	,	,	PUNCT
cusj-10288	375	15	b.	b.	PROPN
cusj-10288	375	16	g.	g.	PROPN
cusj-10288	375	17	,	,	PUNCT
cusj-10288	375	18	sobin	sobin	PROPN
cusj-10288	375	19	,	,	PUNCT
cusj-10288	375	20	l.	l.	PROPN
cusj-10288	375	21	,	,	PUNCT
cusj-10288	375	22	yoder	yoder	PROPN
cusj-10288	375	23	,	,	PUNCT
cusj-10288	375	24	j.	j.	PROPN
cusj-10288	375	25	,	,	PUNCT
cusj-10288	375	26	kegel	kegel	PROPN
cusj-10288	375	27	,	,	PUNCT
cusj-10288	375	28	k.	k.	PROPN
cusj-10288	375	29	b.	b.	PROPN
cusj-10288	375	30	,	,	PUNCT
cusj-10288	375	31	qin	qin	PROPN
cusj-10288	375	32	,	,	PUNCT
cusj-10288	375	33	z.	z.	PROPN
cusj-10288	375	34	h.	h.	PROPN
cusj-10288	375	35	,	,	PUNCT
cusj-10288	375	36	detloff	detloff	PROPN
cusj-10288	375	37	,	,	PUNCT
cusj-10288	375	38	p.	p.	NOUN
cusj-10288	375	39	,	,	PUNCT
cusj-10288	375	40	aronin	aronin	ADV
cusj-10288	375	41	,	,	PUNCT
cusj-10288	375	42	n.	n.	NOUN
cusj-10288	375	43	,	,	PUNCT
cusj-10288	375	44	&	&	CCONJ
cusj-10288	375	45	difiglia	difiglia	PROPN
cusj-10288	375	46	,	,	PUNCT
cusj-10288	375	47	m.	m.	NOUN
cusj-10288	375	48	(	(	PUNCT
cusj-10288	375	49	2006	2006	NUM
cusj-10288	375	50	)	)	PUNCT
cusj-10288	375	51	.	.	PUNCT
cusj-10288	376	1	lysosomal	lysosomal	ADJ
cusj-10288	376	2	proteases	protease	NOUN
cusj-10288	376	3	are	be	AUX
cusj-10288	376	4	involved	involve	VERB
cusj-10288	376	5	in	in	ADP
cusj-10288	376	6	generation	generation	NOUN
cusj-10288	376	7	of	of	ADP
cusj-10288	376	8	n	n	CCONJ
cusj-10288	376	9	-	-	PUNCT
cusj-10288	376	10	terminal	terminal	ADJ
cusj-10288	376	11	huntingtin	huntingtin	NOUN
cusj-10288	376	12	fragments	fragment	NOUN
cusj-10288	376	13	.	.	PUNCT
cusj-10288	377	1	neurobiology	neurobiology	NOUN
cusj-10288	377	2	of	of	ADP
cusj-10288	377	3	disease	disease	NOUN
cusj-10288	377	4	,	,	PUNCT
cusj-10288	377	5	22(2	22(2	NUM
cusj-10288	377	6	)	)	PUNCT
cusj-10288	377	7	,	,	PUNCT
cusj-10288	377	8	346–356	346–356	NUM
cusj-10288	377	9	.	.	PUNCT
cusj-10288	378	1	https://doi.org/10.1016/j.nbd.2005.11.012	https://doi.org/10.1016/j.nbd.2005.11.012	NOUN
cusj-10288	378	2	.	.	PUNCT
cusj-10288	379	1	[	[	X
cusj-10288	379	2	38	38	NUM
cusj-10288	379	3	]	]	X
cusj-10288	379	4	humbert	humbert	PROPN
cusj-10288	379	5	,	,	PUNCT
cusj-10288	379	6	s.	s.	PROPN
cusj-10288	379	7	,	,	PUNCT
cusj-10288	379	8	bryson	bryson	PROPN
cusj-10288	379	9	,	,	PUNCT
cusj-10288	379	10	e.	e.	PROPN
cusj-10288	379	11	a.	a.	PROPN
cusj-10288	379	12	,	,	PUNCT
cusj-10288	379	13	cordelières	cordelière	NOUN
cusj-10288	379	14	,	,	PUNCT
cusj-10288	379	15	f.	f.	PROPN
cusj-10288	379	16	p.	p.	PROPN
cusj-10288	379	17	,	,	PUNCT
cusj-10288	379	18	connors	connor	NOUN
cusj-10288	379	19	,	,	PUNCT
cusj-10288	379	20	n.	n.	PROPN
cusj-10288	379	21	c.	c.	PROPN
cusj-10288	379	22	,	,	PUNCT
cusj-10288	379	23	datta	datta	PROPN
cusj-10288	379	24	,	,	PUNCT
cusj-10288	379	25	s.	s.	PROPN
cusj-10288	379	26	r.	r.	PROPN
cusj-10288	379	27	,	,	PUNCT
cusj-10288	379	28	finkbeiner	finkbeiner	NOUN
cusj-10288	379	29	,	,	PUNCT
cusj-10288	379	30	s.	s.	PROPN
cusj-10288	379	31	,	,	PUNCT
cusj-10288	379	32	greenberg	greenberg	PROPN
cusj-10288	379	33	,	,	PUNCT
cusj-10288	379	34	m.	m.	PROPN
cusj-10288	379	35	e.	e.	PROPN
cusj-10288	379	36	,	,	PUNCT
cusj-10288	379	37	&	&	CCONJ
cusj-10288	379	38	saudou	saudou	PROPN
cusj-10288	379	39	,	,	PUNCT
cusj-10288	379	40	f.	f.	PROPN
cusj-10288	379	41	(	(	PUNCT
cusj-10288	379	42	2002	2002	NUM
cusj-10288	379	43	)	)	PUNCT
cusj-10288	379	44	.	.	PUNCT
cusj-10288	380	1	the	the	DET
cusj-10288	380	2	igf-1	igf-1	NOUN
cusj-10288	380	3	/	/	SYM
cusj-10288	380	4	akt	akt	PROPN
cusj-10288	380	5	pathway	pathway	NOUN
cusj-10288	380	6	is	be	AUX
cusj-10288	380	7	neuroprotective	neuroprotective	ADJ
cusj-10288	380	8	in	in	ADP
cusj-10288	380	9	huntington	huntington	PROPN
cusj-10288	380	10	's	's	PART
cusj-10288	380	11	disease	disease	NOUN
cusj-10288	380	12	and	and	CCONJ
cusj-10288	380	13	involves	involve	VERB
cusj-10288	380	14	huntingtin	huntingtin	ADJ
cusj-10288	380	15	phosphorylation	phosphorylation	NOUN
cusj-10288	380	16	by	by	ADP
cusj-10288	380	17	akt	akt	PROPN
cusj-10288	380	18	.	.	PUNCT
cusj-10288	381	1	developmental	developmental	ADJ
cusj-10288	381	2	cell	cell	NOUN
cusj-10288	381	3	,	,	PUNCT
cusj-10288	381	4	2(6	2(6	NUM
cusj-10288	381	5	)	)	PUNCT
cusj-10288	381	6	,	,	PUNCT
cusj-10288	381	7	831–837	831–837	NUM
cusj-10288	381	8	.	.	PUNCT
cusj-10288	382	1	https://doi.org/10.1016/s15345807(02)00188-0	https://doi.org/10.1016/s15345807(02)00188-0	NOUN
cusj-10288	382	2	.	.	PUNCT
cusj-10288	383	1	[	[	X
cusj-10288	383	2	39	39	NUM
cusj-10288	383	3	]	]	PUNCT
cusj-10288	383	4	metzler	metzler	NOUN
cusj-10288	383	5	,	,	PUNCT
cusj-10288	383	6	m.	m.	NOUN
cusj-10288	383	7	,	,	PUNCT
cusj-10288	383	8	gan	gan	PROPN
cusj-10288	383	9	,	,	PUNCT
cusj-10288	383	10	l.	l.	PROPN
cusj-10288	383	11	,	,	PUNCT
cusj-10288	383	12	mazarei	mazarei	NOUN
cusj-10288	383	13	,	,	PUNCT
cusj-10288	383	14	g.	g.	PROPN
cusj-10288	383	15	,	,	PUNCT
cusj-10288	383	16	graham	graham	PROPN
cusj-10288	383	17	,	,	PUNCT
cusj-10288	383	18	r.	r.	PROPN
cusj-10288	383	19	k.	k.	PROPN
cusj-10288	383	20	,	,	PUNCT
cusj-10288	383	21	liu	liu	PROPN
cusj-10288	383	22	,	,	PUNCT
cusj-10288	383	23	l.	l.	PROPN
cusj-10288	383	24	,	,	PUNCT
cusj-10288	383	25	bissada	bissada	PROPN
cusj-10288	383	26	,	,	PUNCT
cusj-10288	383	27	n.	n.	PROPN
cusj-10288	383	28	,	,	PUNCT
cusj-10288	383	29	lu	lu	PROPN
cusj-10288	383	30	,	,	PUNCT
cusj-10288	383	31	g.	g.	PROPN
cusj-10288	383	32	,	,	PUNCT
cusj-10288	383	33	leavitt	leavitt	PROPN
cusj-10288	383	34	,	,	PUNCT
cusj-10288	383	35	b.	b.	PROPN
cusj-10288	383	36	r.	r.	PROPN
cusj-10288	383	37	,	,	PUNCT
cusj-10288	383	38	&	&	CCONJ
cusj-10288	383	39	hayden	hayden	PROPN
cusj-10288	383	40	,	,	PUNCT
cusj-10288	383	41	m.	m.	PROPN
cusj-10288	383	42	r.	r.	PROPN
cusj-10288	383	43	(	(	PUNCT
cusj-10288	383	44	2010	2010	NUM
cusj-10288	383	45	)	)	PUNCT
cusj-10288	383	46	.	.	PUNCT
cusj-10288	384	1	phosphorylation	phosphorylation	NOUN
cusj-10288	384	2	of	of	ADP
cusj-10288	384	3	huntingtin	huntingtin	NOUN
cusj-10288	384	4	at	at	ADP
cusj-10288	384	5	ser421	ser421	NOUN
cusj-10288	384	6	in	in	ADP
cusj-10288	384	7	yac128	yac128	NOUN
cusj-10288	384	8	neurons	neuron	NOUN
cusj-10288	384	9	is	be	AUX
cusj-10288	384	10	associated	associate	VERB
cusj-10288	384	11	with	with	ADP
cusj-10288	384	12	protection	protection	NOUN
cusj-10288	384	13	of	of	ADP
cusj-10288	384	14	yac128	yac128	NOUN
cusj-10288	384	15	neurons	neuron	NOUN
cusj-10288	384	16	from	from	ADP
cusj-10288	384	17	nmdamediated	nmdamediate	VERB
cusj-10288	384	18	excitotoxicity	excitotoxicity	NOUN
cusj-10288	384	19	and	and	CCONJ
cusj-10288	384	20	is	be	AUX
cusj-10288	384	21	modulated	modulate	VERB
cusj-10288	384	22	by	by	ADP
cusj-10288	384	23	columbia	columbia	PROPN
cusj-10288	384	24	undergraduate	undergraduate	PROPN
cusj-10288	384	25	science	science	PROPN
cusj-10288	384	26	journal	journal	PROPN
cusj-10288	384	27	vol	vol	NOUN
cusj-10288	384	28	.	.	PROPN
cusj-10288	384	29	17	17	NUM
cusj-10288	384	30	,	,	PUNCT
cusj-10288	384	31	2023	2023	NUM
cusj-10288	384	32	datta	datta	NOUN
cusj-10288	384	33	30	30	NUM
cusj-10288	384	34	pp1	pp1	NOUN
cusj-10288	384	35	and	and	CCONJ
cusj-10288	384	36	pp2a	pp2a	PROPN
cusj-10288	384	37	.	.	PUNCT
cusj-10288	385	1	the	the	DET
cusj-10288	385	2	journal	journal	NOUN
cusj-10288	385	3	of	of	ADP
cusj-10288	385	4	neuroscience	neuroscience	NOUN
cusj-10288	385	5	:	:	PUNCT
cusj-10288	385	6	the	the	DET
cusj-10288	385	7	official	official	ADJ
cusj-10288	385	8	journal	journal	NOUN
cusj-10288	385	9	of	of	ADP
cusj-10288	385	10	the	the	DET
cusj-10288	385	11	society	society	NOUN
cusj-10288	385	12	for	for	ADP
cusj-10288	385	13	neuroscience	neuroscience	NOUN
cusj-10288	385	14	,	,	PUNCT
cusj-10288	385	15	30(43	30(43	NUM
cusj-10288	385	16	)	)	PUNCT
cusj-10288	385	17	,	,	PUNCT
cusj-10288	385	18	14318–14329	14318–14329	NUM
cusj-10288	385	19	.	.	PUNCT
cusj-10288	386	1	https://doi.org/10.1523/jneurosci.158910.2010	https://doi.org/10.1523/jneurosci.158910.2010	PROPN
cusj-10288	386	2	.	.	PUNCT
cusj-10288	387	1	[	[	X
cusj-10288	387	2	40	40	NUM
cusj-10288	387	3	]	]	PUNCT
cusj-10288	387	4	yanai	yanai	PROPN
cusj-10288	387	5	,	,	PUNCT
cusj-10288	387	6	a.	a.	PROPN
cusj-10288	387	7	,	,	PUNCT
cusj-10288	387	8	huang	huang	PROPN
cusj-10288	387	9	,	,	PUNCT
cusj-10288	387	10	k.	k.	PROPN
cusj-10288	387	11	,	,	PUNCT
cusj-10288	387	12	kang	kang	PROPN
cusj-10288	387	13	,	,	PUNCT
cusj-10288	387	14	r.	r.	PROPN
cusj-10288	387	15	,	,	PUNCT
cusj-10288	387	16	singaraja	singaraja	PROPN
cusj-10288	387	17	,	,	PUNCT
cusj-10288	387	18	r.	r.	PROPN
cusj-10288	387	19	r.	r.	PROPN
cusj-10288	387	20	,	,	PUNCT
cusj-10288	387	21	arstikaitis	arstikaitis	NOUN
cusj-10288	387	22	,	,	PUNCT
cusj-10288	387	23	p.	p.	PROPN
cusj-10288	387	24	,	,	PUNCT
cusj-10288	387	25	gan	gan	PROPN
cusj-10288	387	26	,	,	PUNCT
cusj-10288	387	27	l.	l.	PROPN
cusj-10288	387	28	,	,	PUNCT
cusj-10288	387	29	orban	orban	NOUN
cusj-10288	387	30	,	,	PUNCT
cusj-10288	387	31	p.	p.	PROPN
cusj-10288	387	32	c.	c.	PROPN
cusj-10288	387	33	,	,	PUNCT
cusj-10288	387	34	mullard	mullard	PROPN
cusj-10288	387	35	,	,	PUNCT
cusj-10288	387	36	a.	a.	PROPN
cusj-10288	387	37	,	,	PUNCT
cusj-10288	387	38	cowan	cowan	PROPN
cusj-10288	387	39	,	,	PUNCT
cusj-10288	387	40	c.	c.	PROPN
cusj-10288	387	41	m.	m.	PROPN
cusj-10288	387	42	,	,	PUNCT
cusj-10288	387	43	raymond	raymond	PROPN
cusj-10288	387	44	,	,	PUNCT
cusj-10288	387	45	l.	l.	PROPN
cusj-10288	387	46	a.	a.	PROPN
cusj-10288	387	47	,	,	PUNCT
cusj-10288	387	48	drisdel	drisdel	PROPN
cusj-10288	387	49	,	,	PUNCT
cusj-10288	387	50	r.	r.	PROPN
cusj-10288	387	51	c.	c.	PROPN
cusj-10288	387	52	,	,	PUNCT
cusj-10288	387	53	green	green	PROPN
cusj-10288	387	54	,	,	PUNCT
cusj-10288	387	55	w.	w.	PROPN
cusj-10288	387	56	n.	n.	PROPN
cusj-10288	387	57	,	,	PUNCT
cusj-10288	387	58	ravikumar	ravikumar	PROPN
cusj-10288	387	59	,	,	PUNCT
cusj-10288	387	60	b.	b.	PROPN
cusj-10288	387	61	,	,	PUNCT
cusj-10288	387	62	rubinsztein	rubinsztein	PROPN
cusj-10288	387	63	,	,	PUNCT
cusj-10288	387	64	d.	d.	PROPN
cusj-10288	387	65	c.	c.	PROPN
cusj-10288	387	66	,	,	PUNCT
cusj-10288	387	67	el	el	PROPN
cusj-10288	387	68	-	-	PUNCT
cusj-10288	387	69	husseini	husseini	PROPN
cusj-10288	387	70	,	,	PUNCT
cusj-10288	387	71	a.	a.	PROPN
cusj-10288	387	72	,	,	PUNCT
cusj-10288	387	73	&	&	CCONJ
cusj-10288	387	74	hayden	hayden	PROPN
cusj-10288	387	75	,	,	PUNCT
cusj-10288	387	76	m.	m.	PROPN
cusj-10288	387	77	r.	r.	PROPN
cusj-10288	387	78	(	(	PUNCT
cusj-10288	387	79	2006	2006	NUM
cusj-10288	387	80	)	)	PUNCT
cusj-10288	387	81	.	.	PUNCT
cusj-10288	388	1	palmitoylation	palmitoylation	NOUN
cusj-10288	388	2	of	of	ADP
cusj-10288	388	3	huntingtin	huntingtin	NOUN
cusj-10288	388	4	by	by	ADP
cusj-10288	388	5	hip14	hip14	PROPN
cusj-10288	388	6	is	be	AUX
cusj-10288	388	7	essential	essential	ADJ
cusj-10288	388	8	for	for	ADP
cusj-10288	388	9	its	its	PRON
cusj-10288	388	10	trafficking	trafficking	NOUN
cusj-10288	388	11	and	and	CCONJ
cusj-10288	388	12	function	function	NOUN
cusj-10288	388	13	.	.	PUNCT
cusj-10288	389	1	nature	nature	NOUN
cusj-10288	389	2	neuroscience	neuroscience	NOUN
cusj-10288	389	3	,	,	PUNCT
cusj-10288	389	4	9(6	9(6	NUM
cusj-10288	389	5	)	)	PUNCT
cusj-10288	389	6	,	,	PUNCT
cusj-10288	389	7	824–831	824–831	NUM
cusj-10288	389	8	.	.	PUNCT
cusj-10288	390	1	https://doi.org/10.1038/nn1702	https://doi.org/10.1038/nn1702	PROPN
cusj-10288	390	2	.	.	PUNCT
cusj-10288	391	1	[	[	X
cusj-10288	391	2	41	41	NUM
cusj-10288	391	3	]	]	X
cusj-10288	391	4	difiglia	difiglia	NOUN
cusj-10288	391	5	,	,	PUNCT
cusj-10288	391	6	m.	m.	NOUN
cusj-10288	391	7	,	,	PUNCT
cusj-10288	391	8	sapp	sapp	PROPN
cusj-10288	391	9	,	,	PUNCT
cusj-10288	391	10	e.	e.	PROPN
cusj-10288	391	11	,	,	PUNCT
cusj-10288	391	12	chase	chase	PROPN
cusj-10288	391	13	,	,	PUNCT
cusj-10288	391	14	k.	k.	PROPN
cusj-10288	391	15	,	,	PUNCT
cusj-10288	391	16	schwarz	schwarz	PROPN
cusj-10288	391	17	,	,	PUNCT
cusj-10288	391	18	c.	c.	PROPN
cusj-10288	391	19	,	,	PUNCT
cusj-10288	391	20	meloni	meloni	PROPN
cusj-10288	391	21	,	,	PUNCT
cusj-10288	391	22	a.	a.	NOUN
cusj-10288	391	23	,	,	PUNCT
cusj-10288	391	24	young	young	ADJ
cusj-10288	391	25	,	,	PUNCT
cusj-10288	391	26	c.	c.	PROPN
cusj-10288	391	27	,	,	PUNCT
cusj-10288	391	28	martin	martin	PROPN
cusj-10288	391	29	,	,	PUNCT
cusj-10288	391	30	e.	e.	PROPN
cusj-10288	391	31	,	,	PUNCT
cusj-10288	391	32	vonsattel	vonsattel	PROPN
cusj-10288	391	33	,	,	PUNCT
cusj-10288	391	34	j.	j.	PROPN
cusj-10288	391	35	p.	p.	PROPN
cusj-10288	391	36	,	,	PUNCT
cusj-10288	391	37	carraway	carraway	PROPN
cusj-10288	391	38	,	,	PUNCT
cusj-10288	391	39	r.	r.	PROPN
cusj-10288	391	40	,	,	PUNCT
cusj-10288	391	41	&	&	CCONJ
cusj-10288	391	42	reeves	reeves	PROPN
cusj-10288	391	43	,	,	PUNCT
cusj-10288	391	44	s.	s.	PROPN
cusj-10288	391	45	a.	a.	PROPN
cusj-10288	391	46	(	(	PUNCT
cusj-10288	391	47	1995	1995	NUM
cusj-10288	391	48	)	)	PUNCT
cusj-10288	391	49	.	.	PUNCT
cusj-10288	392	1	huntingtin	huntingtin	PROPN
cusj-10288	392	2	is	be	AUX
cusj-10288	392	3	a	a	DET
cusj-10288	392	4	cytoplasmic	cytoplasmic	ADJ
cusj-10288	392	5	protein	protein	NOUN
cusj-10288	392	6	associated	associate	VERB
cusj-10288	392	7	with	with	ADP
cusj-10288	392	8	vesicles	vesicle	NOUN
cusj-10288	392	9	in	in	ADP
cusj-10288	392	10	human	human	ADJ
cusj-10288	392	11	and	and	CCONJ
cusj-10288	392	12	rat	rat	NOUN
cusj-10288	392	13	brain	brain	NOUN
cusj-10288	392	14	neurons	neuron	NOUN
cusj-10288	392	15	.	.	PUNCT
cusj-10288	393	1	neuron	neuron	PROPN
cusj-10288	393	2	,	,	PUNCT
cusj-10288	393	3	14(5	14(5	PROPN
cusj-10288	393	4	)	)	PUNCT
cusj-10288	393	5	,	,	PUNCT
cusj-10288	393	6	1075	1075	NUM
cusj-10288	393	7	–	–	PUNCT
cusj-10288	393	8	1081	1081	NUM
cusj-10288	393	9	.	.	PUNCT
cusj-10288	394	1	https://doi.org/10.1016/08966273(95)90346-1	https://doi.org/10.1016/08966273(95)90346-1	NOUN
cusj-10288	394	2	.	.	PUNCT
cusj-10288	395	1	[	[	X
cusj-10288	395	2	42	42	NUM
cusj-10288	395	3	]	]	X
cusj-10288	395	4	hebb	hebb	PROPN
cusj-10288	395	5	,	,	PUNCT
cusj-10288	395	6	m.	m.	NOUN
cusj-10288	395	7	o.	o.	PROPN
cusj-10288	395	8	,	,	PUNCT
cusj-10288	395	9	denovan	denovan	PROPN
cusj-10288	395	10	-	-	PUNCT
cusj-10288	395	11	wright	wright	PROPN
cusj-10288	395	12	,	,	PUNCT
cusj-10288	395	13	e.	e.	PROPN
cusj-10288	395	14	m.	m.	PROPN
cusj-10288	395	15	,	,	PUNCT
cusj-10288	395	16	&	&	CCONJ
cusj-10288	395	17	robertson	robertson	PROPN
cusj-10288	395	18	,	,	PUNCT
cusj-10288	395	19	h.	h.	PROPN
cusj-10288	395	20	a.	a.	PROPN
cusj-10288	395	21	(	(	PUNCT
cusj-10288	395	22	1999	1999	NUM
cusj-10288	395	23	)	)	PUNCT
cusj-10288	395	24	.	.	PUNCT
cusj-10288	396	1	expression	expression	NOUN
cusj-10288	396	2	of	of	ADP
cusj-10288	396	3	the	the	DET
cusj-10288	396	4	huntington	huntington	PROPN
cusj-10288	396	5	's	's	PART
cusj-10288	396	6	disease	disease	NOUN
cusj-10288	396	7	gene	gene	NOUN
cusj-10288	396	8	is	be	AUX
cusj-10288	396	9	regulated	regulate	VERB
cusj-10288	396	10	in	in	ADP
cusj-10288	396	11	astrocytes	astrocyte	NOUN
cusj-10288	396	12	in	in	ADP
cusj-10288	396	13	the	the	DET
cusj-10288	396	14	arcuate	arcuate	ADJ
cusj-10288	396	15	nucleus	nucleus	NOUN
cusj-10288	396	16	of	of	ADP
cusj-10288	396	17	the	the	DET
cusj-10288	396	18	hypothalamus	hypothalamus	NOUN
cusj-10288	396	19	of	of	ADP
cusj-10288	396	20	postpartum	postpartum	NOUN
cusj-10288	396	21	rats	rat	NOUN
cusj-10288	396	22	.	.	PUNCT
cusj-10288	397	1	faseb	faseb	PROPN
cusj-10288	397	2	journal	journal	PROPN
cusj-10288	397	3	:	:	PUNCT
cusj-10288	397	4	official	official	ADJ
cusj-10288	397	5	publication	publication	NOUN
cusj-10288	397	6	of	of	ADP
cusj-10288	397	7	the	the	DET
cusj-10288	397	8	federation	federation	PROPN
cusj-10288	397	9	of	of	ADP
cusj-10288	397	10	american	american	ADJ
cusj-10288	397	11	societies	society	NOUN
cusj-10288	397	12	for	for	ADP
cusj-10288	397	13	experimental	experimental	ADJ
cusj-10288	397	14	biology	biology	NOUN
cusj-10288	397	15	,	,	PUNCT
cusj-10288	397	16	13(9	13(9	NUM
cusj-10288	397	17	)	)	PUNCT
cusj-10288	397	18	,	,	PUNCT
cusj-10288	397	19	1099–1106	1099–1106	NUM
cusj-10288	397	20	.	.	PUNCT
cusj-10288	398	1	https://doi.org/10.1096/fasebj.13.9.1099	https://doi.org/10.1096/fasebj.13.9.1099	VERB
cusj-10288	398	2	.	.	PUNCT
cusj-10288	399	1	[	[	X
cusj-10288	399	2	43	43	NUM
cusj-10288	399	3	]	]	X
cusj-10288	399	4	ko	ko	PROPN
cusj-10288	399	5	,	,	PUNCT
cusj-10288	399	6	j.	j.	PROPN
cusj-10288	399	7	,	,	PUNCT
cusj-10288	399	8	ou	ou	PROPN
cusj-10288	399	9	,	,	PUNCT
cusj-10288	399	10	s.	s.	PROPN
cusj-10288	399	11	,	,	PUNCT
cusj-10288	399	12	&	&	CCONJ
cusj-10288	399	13	patterson	patterson	PROPN
cusj-10288	399	14	,	,	PUNCT
cusj-10288	399	15	p.	p.	PROPN
cusj-10288	399	16	h.	h.	PROPN
cusj-10288	399	17	(	(	PUNCT
cusj-10288	399	18	2001	2001	NUM
cusj-10288	399	19	)	)	PUNCT
cusj-10288	399	20	.	.	PUNCT
cusj-10288	400	1	new	new	ADJ
cusj-10288	400	2	anti	anti	ADJ
cusj-10288	400	3	-	-	ADJ
cusj-10288	400	4	huntingtin	huntingtin	ADJ
cusj-10288	400	5	monoclonal	monoclonal	NOUN
cusj-10288	400	6	antibodies	antibodie	VERB
cusj-10288	400	7	:	:	PUNCT
cusj-10288	400	8	implications	implication	NOUN
cusj-10288	400	9	for	for	ADP
cusj-10288	400	10	huntingtin	huntingtin	NOUN
cusj-10288	400	11	conformation	conformation	NOUN
cusj-10288	400	12	and	and	CCONJ
cusj-10288	400	13	its	its	PRON
cusj-10288	400	14	binding	bind	VERB
cusj-10288	400	15	proteins	protein	NOUN
cusj-10288	400	16	.	.	PUNCT
cusj-10288	401	1	brain	brain	NOUN
cusj-10288	401	2	research	research	NOUN
cusj-10288	401	3	bulletin	bulletin	NOUN
cusj-10288	401	4	,	,	PUNCT
cusj-10288	401	5	56(3	56(3	NOUN
cusj-10288	401	6	-	-	SYM
cusj-10288	401	7	4	4	NUM
cusj-10288	401	8	)	)	PUNCT
cusj-10288	401	9	,	,	PUNCT
cusj-10288	401	10	319–329	319–329	NUM
cusj-10288	401	11	.	.	PUNCT
cusj-10288	401	12	https://doi.org/10.1016/s03619230(01)00599-8	https://doi.org/10.1016/s03619230(01)00599-8	NOUN
cusj-10288	401	13	.	.	PUNCT
cusj-10288	402	1	[	[	X
cusj-10288	402	2	44	44	NUM
cusj-10288	402	3	]	]	X
cusj-10288	402	4	borrell	borrell	PROPN
cusj-10288	402	5	-	-	PUNCT
cusj-10288	402	6	pagès	pagès	NOUN
cusj-10288	402	7	,	,	PUNCT
cusj-10288	402	8	m.	m.	NOUN
cusj-10288	402	9	,	,	PUNCT
cusj-10288	402	10	zala	zala	PROPN
cusj-10288	402	11	,	,	PUNCT
cusj-10288	402	12	d.	d.	PROPN
cusj-10288	402	13	,	,	PUNCT
cusj-10288	402	14	humbert	humbert	PROPN
cusj-10288	402	15	,	,	PUNCT
cusj-10288	402	16	s.	s.	PROPN
cusj-10288	402	17	,	,	PUNCT
cusj-10288	402	18	&	&	CCONJ
cusj-10288	402	19	saudou	saudou	PROPN
cusj-10288	402	20	,	,	PUNCT
cusj-10288	402	21	f.	f.	PROPN
cusj-10288	402	22	(	(	PUNCT
cusj-10288	402	23	2006	2006	NUM
cusj-10288	402	24	)	)	PUNCT
cusj-10288	402	25	.	.	PUNCT
cusj-10288	403	1	huntington	huntington	PROPN
cusj-10288	403	2	's	's	PART
cusj-10288	403	3	disease	disease	NOUN
cusj-10288	403	4	:	:	PUNCT
cusj-10288	403	5	from	from	ADP
cusj-10288	403	6	huntingtin	huntingtin	NOUN
cusj-10288	403	7	function	function	NOUN
cusj-10288	403	8	and	and	CCONJ
cusj-10288	403	9	dysfunction	dysfunction	NOUN
cusj-10288	403	10	to	to	ADP
cusj-10288	403	11	therapeutic	therapeutic	ADJ
cusj-10288	403	12	strategies	strategy	NOUN
cusj-10288	403	13	.	.	PUNCT
cusj-10288	404	1	cellular	cellular	ADJ
cusj-10288	404	2	and	and	CCONJ
cusj-10288	404	3	molecular	molecular	ADJ
cusj-10288	404	4	life	life	NOUN
cusj-10288	404	5	sciences	science	NOUN
cusj-10288	404	6	:	:	PUNCT
cusj-10288	404	7	cmls	cmls	NOUN
cusj-10288	404	8	,	,	PUNCT
cusj-10288	404	9	63(22	63(22	NUM
cusj-10288	404	10	)	)	PUNCT
cusj-10288	404	11	,	,	PUNCT
cusj-10288	404	12	2642–2660	2642–2660	NOUN
cusj-10288	404	13	.	.	PUNCT
cusj-10288	405	1	https://doi.org/10.1007/s00018-006-6242-0	https://doi.org/10.1007/s00018-006-6242-0	NUM
cusj-10288	405	2	.	.	PUNCT
cusj-10288	406	1	[	[	X
cusj-10288	406	2	45	45	NUM
cusj-10288	406	3	]	]	X
cusj-10288	406	4	semaka	semaka	PROPN
cusj-10288	406	5	,	,	PUNCT
cusj-10288	406	6	a.	a.	PROPN
cusj-10288	406	7	,	,	PUNCT
cusj-10288	406	8	creighton	creighton	PROPN
cusj-10288	406	9	,	,	PUNCT
cusj-10288	406	10	s.	s.	PROPN
cusj-10288	406	11	,	,	PUNCT
cusj-10288	406	12	warby	warby	PROPN
cusj-10288	406	13	,	,	PUNCT
cusj-10288	406	14	s.	s.	PROPN
cusj-10288	406	15	,	,	PUNCT
cusj-10288	406	16	&	&	CCONJ
cusj-10288	406	17	hayden	hayden	PROPN
cusj-10288	406	18	,	,	PUNCT
cusj-10288	406	19	m.	m.	PROPN
cusj-10288	406	20	r.	r.	PROPN
cusj-10288	406	21	(	(	PUNCT
cusj-10288	406	22	2006	2006	NUM
cusj-10288	406	23	)	)	PUNCT
cusj-10288	406	24	.	.	PUNCT
cusj-10288	407	1	predictive	predictive	ADJ
cusj-10288	407	2	testing	testing	NOUN
cusj-10288	407	3	for	for	ADP
cusj-10288	407	4	huntington	huntington	PROPN
cusj-10288	407	5	disease	disease	PROPN
cusj-10288	407	6	:	:	PUNCT
cusj-10288	407	7	interpretation	interpretation	NOUN
cusj-10288	407	8	and	and	CCONJ
cusj-10288	407	9	significance	significance	NOUN
cusj-10288	407	10	of	of	ADP
cusj-10288	407	11	intermediate	intermediate	ADJ
cusj-10288	407	12	alleles	allele	NOUN
cusj-10288	407	13	.	.	PUNCT
cusj-10288	408	1	clinical	clinical	ADJ
cusj-10288	408	2	genetics	genetic	NOUN
cusj-10288	408	3	,	,	PUNCT
cusj-10288	408	4	70(4	70(4	NUM
cusj-10288	408	5	)	)	PUNCT
cusj-10288	408	6	,	,	PUNCT
cusj-10288	408	7	283–294	283–294	NUM
cusj-10288	408	8	.	.	PUNCT
cusj-10288	409	1	https://doi.org/10.1111/j.13990004.2006.00668.x	https://doi.org/10.1111/j.13990004.2006.00668.x	X
cusj-10288	409	2	.	.	PUNCT
cusj-10288	410	1	[	[	X
cusj-10288	410	2	46	46	NUM
cusj-10288	410	3	]	]	PUNCT
cusj-10288	410	4	s.	s.	PROPN
cusj-10288	410	5	mahalingam	mahalingam	PROPN
cusj-10288	410	6	and	and	CCONJ
cusj-10288	410	7	l.m	l.m	PROPN
cusj-10288	410	8	.	.	PROPN
cusj-10288	410	9	levy	levy	NOUN
cusj-10288	410	10	(	(	PUNCT
cusj-10288	410	11	2014	2014	NUM
cusj-10288	410	12	)	)	PUNCT
cusj-10288	410	13	.	.	PUNCT
cusj-10288	411	1	genetics	genetic	NOUN
cusj-10288	411	2	of	of	ADP
cusj-10288	411	3	huntington	huntington	PROPN
cusj-10288	411	4	disease	disease	PROPN
cusj-10288	411	5	american	american	PROPN
cusj-10288	411	6	journal	journal	PROPN
cusj-10288	411	7	of	of	ADP
cusj-10288	411	8	neuroradiology	neuroradiology	NOUN
cusj-10288	411	9	35	35	NUM
cusj-10288	411	10	(	(	PUNCT
cusj-10288	411	11	6	6	NUM
cusj-10288	411	12	)	)	PUNCT
cusj-10288	411	13	1070	1070	NUM
cusj-10288	411	14	-	-	SYM
cusj-10288	411	15	1072	1072	NUM
cusj-10288	411	16	;	;	PUNCT
cusj-10288	411	17	doi	doi	NOUN
cusj-10288	411	18	:	:	PUNCT
cusj-10288	411	19	https://doi.org/10.3174/ajnr.a3772	https://doi.org/10.3174/ajnr.a3772	PROPN
cusj-10288	411	20	.	.	PUNCT
cusj-10288	412	1	[	[	X
cusj-10288	412	2	47	47	NUM
cusj-10288	412	3	]	]	X
cusj-10288	412	4	walker	walker	PROPN
cusj-10288	412	5	f.	f.	PROPN
cusj-10288	412	6	o.	o.	PROPN
cusj-10288	412	7	(	(	PUNCT
cusj-10288	412	8	2007	2007	NUM
cusj-10288	412	9	)	)	PUNCT
cusj-10288	412	10	.	.	PUNCT
cusj-10288	413	1	huntington	huntington	PROPN
cusj-10288	413	2	's	's	PART
cusj-10288	413	3	disease	disease	NOUN
cusj-10288	413	4	.	.	PUNCT
cusj-10288	414	1	lancet	lancet	PROPN
cusj-10288	414	2	(	(	PUNCT
cusj-10288	414	3	london	london	PROPN
cusj-10288	414	4	,	,	PUNCT
cusj-10288	414	5	england	england	PROPN
cusj-10288	414	6	)	)	PUNCT
cusj-10288	414	7	,	,	PUNCT
cusj-10288	414	8	369(9557	369(9557	NUM
cusj-10288	414	9	)	)	PUNCT
cusj-10288	414	10	,	,	PUNCT
cusj-10288	414	11	218–228	218–228	NUM
cusj-10288	414	12	.	.	PUNCT
cusj-10288	414	13	https://doi.org/10.1016/s01406736(07)60111-1	https://doi.org/10.1016/s01406736(07)60111-1	NOUN
cusj-10288	414	14	.	.	PUNCT
cusj-10288	415	1	[	[	X
cusj-10288	415	2	48	48	NUM
cusj-10288	415	3	]	]	PUNCT
cusj-10288	415	4	tabrizi	tabrizi	NOUN
cusj-10288	415	5	,	,	PUNCT
cusj-10288	415	6	s.	s.	PROPN
cusj-10288	415	7	j.	j.	PROPN
cusj-10288	415	8	,	,	PUNCT
cusj-10288	415	9	langbehn	langbehn	PROPN
cusj-10288	415	10	,	,	PUNCT
cusj-10288	415	11	d.	d.	PROPN
cusj-10288	415	12	r.	r.	PROPN
cusj-10288	415	13	,	,	PUNCT
cusj-10288	415	14	leavitt	leavitt	PROPN
cusj-10288	415	15	,	,	PUNCT
cusj-10288	415	16	b.	b.	PROPN
cusj-10288	415	17	r.	r.	PROPN
cusj-10288	415	18	,	,	PUNCT
cusj-10288	415	19	roos	roos	PROPN
cusj-10288	415	20	,	,	PUNCT
cusj-10288	415	21	r.	r.	PROPN
cusj-10288	415	22	a.	a.	PROPN
cusj-10288	415	23	,	,	PUNCT
cusj-10288	415	24	durr	durr	PROPN
cusj-10288	415	25	,	,	PUNCT
cusj-10288	415	26	a.	a.	NOUN
cusj-10288	415	27	,	,	PUNCT
cusj-10288	415	28	craufurd	craufurd	PROPN
cusj-10288	415	29	,	,	PUNCT
cusj-10288	415	30	d.	d.	PROPN
cusj-10288	415	31	,	,	PUNCT
cusj-10288	415	32	kennard	kennard	PROPN
cusj-10288	415	33	,	,	PUNCT
cusj-10288	415	34	c.	c.	PROPN
cusj-10288	415	35	,	,	PUNCT
cusj-10288	415	36	hicks	hicks	PROPN
cusj-10288	415	37	,	,	PUNCT
cusj-10288	415	38	s.	s.	PROPN
cusj-10288	415	39	l.	l.	PROPN
cusj-10288	415	40	,	,	PUNCT
cusj-10288	415	41	fox	fox	PROPN
cusj-10288	415	42	,	,	PUNCT
cusj-10288	415	43	n.	n.	PROPN
cusj-10288	415	44	c.	c.	PROPN
cusj-10288	415	45	,	,	PUNCT
cusj-10288	415	46	scahill	scahill	PROPN
cusj-10288	415	47	,	,	PUNCT
cusj-10288	415	48	r.	r.	PROPN
cusj-10288	415	49	i.	i.	PROPN
cusj-10288	415	50	,	,	PUNCT
cusj-10288	415	51	borowsky	borowsky	PROPN
cusj-10288	415	52	,	,	PUNCT
cusj-10288	415	53	b.	b.	PROPN
cusj-10288	415	54	,	,	PUNCT
cusj-10288	415	55	tobin	tobin	PROPN
cusj-10288	415	56	,	,	PUNCT
cusj-10288	415	57	a.	a.	PROPN
cusj-10288	415	58	j.	j.	PROPN
cusj-10288	415	59	,	,	PUNCT
cusj-10288	415	60	rosas	rosas	PROPN
cusj-10288	415	61	,	,	PUNCT
cusj-10288	415	62	h.	h.	PROPN
cusj-10288	415	63	d.	d.	PROPN
cusj-10288	415	64	,	,	PUNCT
cusj-10288	415	65	johnson	johnson	PROPN
cusj-10288	415	66	,	,	PUNCT
cusj-10288	415	67	h.	h.	PROPN
cusj-10288	415	68	,	,	PUNCT
cusj-10288	415	69	reilmann	reilmann	PROPN
cusj-10288	415	70	,	,	PUNCT
cusj-10288	415	71	r.	r.	PROPN
cusj-10288	415	72	,	,	PUNCT
cusj-10288	415	73	landwehrmeyer	landwehrmeyer	PROPN
cusj-10288	415	74	,	,	PUNCT
cusj-10288	415	75	b.	b.	PROPN
cusj-10288	415	76	,	,	PUNCT
cusj-10288	415	77	stout	stout	PROPN
cusj-10288	415	78	,	,	PUNCT
cusj-10288	415	79	j.	j.	PROPN
cusj-10288	415	80	c.	c.	PROPN
cusj-10288	415	81	,	,	PUNCT
cusj-10288	415	82	&	&	CCONJ
cusj-10288	415	83	track	track	NOUN
cusj-10288	415	84	-	-	PUNCT
cusj-10288	415	85	hd	hd	NOUN
cusj-10288	415	86	investigators	investigator	NOUN
cusj-10288	415	87	(	(	PUNCT
cusj-10288	415	88	2009	2009	NUM
cusj-10288	415	89	)	)	PUNCT
cusj-10288	415	90	.	.	PUNCT
cusj-10288	416	1	biological	biological	ADJ
cusj-10288	416	2	and	and	CCONJ
cusj-10288	416	3	clinical	clinical	ADJ
cusj-10288	416	4	manifestations	manifestation	NOUN
cusj-10288	416	5	of	of	ADP
cusj-10288	416	6	huntington	huntington	PROPN
cusj-10288	416	7	's	's	PART
cusj-10288	416	8	disease	disease	NOUN
cusj-10288	416	9	in	in	ADP
cusj-10288	416	10	the	the	DET
cusj-10288	416	11	longitudinal	longitudinal	ADJ
cusj-10288	416	12	track	track	NOUN
cusj-10288	416	13	-	-	PUNCT
cusj-10288	416	14	hd	hd	NOUN
cusj-10288	416	15	study	study	NOUN
cusj-10288	416	16	:	:	PUNCT
cusj-10288	416	17	crosssectional	crosssectional	ADJ
cusj-10288	416	18	analysis	analysis	NOUN
cusj-10288	416	19	of	of	ADP
cusj-10288	416	20	baseline	baseline	ADJ
cusj-10288	416	21	data	datum	NOUN
cusj-10288	416	22	.	.	PUNCT
cusj-10288	417	1	the	the	DET
cusj-10288	417	2	lancet	lancet	PROPN
cusj-10288	417	3	.	.	PUNCT
cusj-10288	418	1	neurology	neurology	NOUN
cusj-10288	418	2	,	,	PUNCT
cusj-10288	418	3	8(9	8(9	NUM
cusj-10288	418	4	)	)	PUNCT
cusj-10288	418	5	,	,	PUNCT
cusj-10288	418	6	791–801	791–801	NUM
cusj-10288	418	7	.	.	PUNCT
cusj-10288	419	1	https://doi.org/10.1016/s14744422(09)70170-x	https://doi.org/10.1016/s14744422(09)70170-x	PROPN
cusj-10288	419	2	.	.	PUNCT
cusj-10288	420	1	[	[	X
cusj-10288	420	2	49	49	NUM
cusj-10288	420	3	]	]	PUNCT
cusj-10288	420	4	trottier	trottier	VERB
cusj-10288	420	5	,	,	PUNCT
cusj-10288	420	6	y.	y.	PROPN
cusj-10288	420	7	,	,	PUNCT
cusj-10288	420	8	devys	devys	PROPN
cusj-10288	420	9	,	,	PUNCT
cusj-10288	420	10	d.	d.	PROPN
cusj-10288	420	11	,	,	PUNCT
cusj-10288	420	12	imbert	imbert	PROPN
cusj-10288	420	13	,	,	PUNCT
cusj-10288	420	14	g.	g.	PROPN
cusj-10288	420	15	,	,	PUNCT
cusj-10288	420	16	saudou	saudou	NOUN
cusj-10288	420	17	,	,	PUNCT
cusj-10288	420	18	f.	f.	PROPN
cusj-10288	420	19	,	,	PUNCT
cusj-10288	420	20	an	an	PRON
cusj-10288	420	21	,	,	PUNCT
cusj-10288	420	22	i.	i.	NOUN
cusj-10288	420	23	,	,	PUNCT
cusj-10288	420	24	lutz	lutz	PROPN
cusj-10288	420	25	,	,	PUNCT
cusj-10288	420	26	y.	y.	PROPN
cusj-10288	420	27	,	,	PUNCT
cusj-10288	420	28	weber	weber	PROPN
cusj-10288	420	29	,	,	PUNCT
cusj-10288	420	30	c.	c.	PROPN
cusj-10288	420	31	,	,	PUNCT
cusj-10288	420	32	agid	agid	ADJ
cusj-10288	420	33	,	,	PUNCT
cusj-10288	420	34	y.	y.	PROPN
cusj-10288	420	35	,	,	PUNCT
cusj-10288	420	36	hirsch	hirsch	PROPN
cusj-10288	420	37	,	,	PUNCT
cusj-10288	420	38	e.	e.	PROPN
cusj-10288	420	39	c.	c.	PROPN
cusj-10288	420	40	,	,	PUNCT
cusj-10288	420	41	&	&	CCONJ
cusj-10288	420	42	mandel	mandel	PROPN
cusj-10288	420	43	,	,	PUNCT
cusj-10288	420	44	j.	j.	PROPN
cusj-10288	420	45	l.	l.	PROPN
cusj-10288	420	46	(	(	PUNCT
cusj-10288	420	47	1995	1995	NUM
cusj-10288	420	48	)	)	PUNCT
cusj-10288	420	49	.	.	PUNCT
cusj-10288	421	1	cellular	cellular	ADJ
cusj-10288	421	2	localization	localization	NOUN
cusj-10288	421	3	of	of	ADP
cusj-10288	421	4	the	the	DET
cusj-10288	421	5	huntington	huntington	PROPN
cusj-10288	421	6	's	's	PART
cusj-10288	421	7	disease	disease	NOUN
cusj-10288	421	8	protein	protein	NOUN
cusj-10288	421	9	and	and	CCONJ
cusj-10288	421	10	discrimination	discrimination	NOUN
cusj-10288	421	11	of	of	ADP
cusj-10288	421	12	the	the	DET
cusj-10288	421	13	normal	normal	ADJ
cusj-10288	421	14	and	and	CCONJ
cusj-10288	421	15	mutated	mutate	VERB
cusj-10288	421	16	form	form	NOUN
cusj-10288	421	17	.	.	PUNCT
cusj-10288	422	1	nature	nature	NOUN
cusj-10288	422	2	genetics	genetic	NOUN
cusj-10288	422	3	,	,	PUNCT
cusj-10288	422	4	10(1	10(1	NUM
cusj-10288	422	5	)	)	PUNCT
cusj-10288	422	6	,	,	PUNCT
cusj-10288	422	7	104	104	NUM
cusj-10288	422	8	–	–	SYM
cusj-10288	422	9	110	110	NUM
cusj-10288	422	10	.	.	PUNCT
cusj-10288	423	1	https://doi.org/10.1038/ng0595-104	https://doi.org/10.1038/ng0595-104	X
cusj-10288	423	2	.	.	PUNCT
cusj-10288	424	1	[	[	X
cusj-10288	424	2	50	50	NUM
cusj-10288	424	3	]	]	X
cusj-10288	424	4	bates	bates	PROPN
cusj-10288	424	5	g.	g.	PROPN
cusj-10288	424	6	(	(	PUNCT
cusj-10288	424	7	2003	2003	NUM
cusj-10288	424	8	)	)	PUNCT
cusj-10288	424	9	.	.	PUNCT
cusj-10288	425	1	huntingtin	huntingtin	PROPN
cusj-10288	425	2	aggregation	aggregation	NOUN
cusj-10288	425	3	and	and	CCONJ
cusj-10288	425	4	toxicity	toxicity	NOUN
cusj-10288	425	5	in	in	ADP
cusj-10288	425	6	huntington	huntington	PROPN
cusj-10288	425	7	's	's	PART
cusj-10288	425	8	disease	disease	NOUN
cusj-10288	425	9	.	.	PUNCT
cusj-10288	426	1	lancet	lancet	PROPN
cusj-10288	426	2	(	(	PUNCT
cusj-10288	426	3	london	london	PROPN
cusj-10288	426	4	,	,	PUNCT
cusj-10288	426	5	england	england	PROPN
cusj-10288	426	6	)	)	PUNCT
cusj-10288	426	7	,	,	PUNCT
cusj-10288	426	8	361(9369	361(9369	NUM
cusj-10288	426	9	)	)	PUNCT
cusj-10288	426	10	,	,	PUNCT
cusj-10288	426	11	1642–1644	1642–1644	NUM
cusj-10288	426	12	.	.	PUNCT
cusj-10288	427	1	columbia	columbia	PROPN
cusj-10288	427	2	undergraduate	undergraduate	PROPN
cusj-10288	427	3	science	science	PROPN
cusj-10288	427	4	journal	journal	PROPN
cusj-10288	427	5	vol	vol	NOUN
cusj-10288	427	6	.	.	PROPN
cusj-10288	427	7	17	17	NUM
cusj-10288	427	8	,	,	PUNCT
cusj-10288	427	9	2023	2023	NUM
cusj-10288	427	10	datta	datta	NOUN
cusj-10288	427	11	31	31	NUM
cusj-10288	427	12	https://doi.org/10.1016/s01406736(03)13304-1	https://doi.org/10.1016/s01406736(03)13304-1	NOUN
cusj-10288	427	13	.	.	PUNCT
cusj-10288	428	1	[	[	X
cusj-10288	428	2	51	51	NUM
cusj-10288	428	3	]	]	PUNCT
cusj-10288	428	4	ross	ross	PROPN
cusj-10288	428	5	,	,	PUNCT
cusj-10288	428	6	c.	c.	PROPN
cusj-10288	428	7	a.	a.	PROPN
cusj-10288	428	8	,	,	PUNCT
cusj-10288	428	9	&	&	CCONJ
cusj-10288	428	10	tabrizi	tabrizi	NOUN
cusj-10288	428	11	,	,	PUNCT
cusj-10288	428	12	s.	s.	PROPN
cusj-10288	428	13	j.	j.	PROPN
cusj-10288	428	14	(	(	PUNCT
cusj-10288	428	15	2011	2011	NUM
cusj-10288	428	16	)	)	PUNCT
cusj-10288	428	17	.	.	PUNCT
cusj-10288	429	1	huntington	huntington	PROPN
cusj-10288	429	2	's	's	PART
cusj-10288	429	3	disease	disease	NOUN
cusj-10288	429	4	:	:	PUNCT
cusj-10288	429	5	from	from	ADP
cusj-10288	429	6	molecular	molecular	ADJ
cusj-10288	429	7	pathogenesis	pathogenesis	NOUN
cusj-10288	429	8	to	to	ADP
cusj-10288	429	9	clinical	clinical	ADJ
cusj-10288	429	10	treatment	treatment	NOUN
cusj-10288	429	11	.	.	PUNCT
cusj-10288	430	1	the	the	DET
cusj-10288	430	2	lancet	lancet	PROPN
cusj-10288	430	3	.	.	PUNCT
cusj-10288	431	1	neurology	neurology	NOUN
cusj-10288	431	2	,	,	PUNCT
cusj-10288	431	3	10(1	10(1	NUM
cusj-10288	431	4	)	)	PUNCT
cusj-10288	431	5	,	,	PUNCT
cusj-10288	431	6	83–98	83–98	NUM
cusj-10288	431	7	.	.	PUNCT
cusj-10288	432	1	https://doi.org/10.1016/s14744422(10)70245-3	https://doi.org/10.1016/s14744422(10)70245-3	NOUN
cusj-10288	432	2	.	.	PUNCT
cusj-10288	433	1	[	[	X
cusj-10288	433	2	52	52	NUM
cusj-10288	433	3	]	]	X
cusj-10288	433	4	walker	walker	PROPN
cusj-10288	433	5	f.	f.	PROPN
cusj-10288	433	6	o.	o.	PROPN
cusj-10288	433	7	(	(	PUNCT
cusj-10288	433	8	2007	2007	NUM
cusj-10288	433	9	)	)	PUNCT
cusj-10288	433	10	.	.	PUNCT
cusj-10288	434	1	huntington	huntington	PROPN
cusj-10288	434	2	's	's	PART
cusj-10288	434	3	disease	disease	NOUN
cusj-10288	434	4	.	.	PUNCT
cusj-10288	435	1	lancet	lancet	PROPN
cusj-10288	435	2	(	(	PUNCT
cusj-10288	435	3	london	london	PROPN
cusj-10288	435	4	,	,	PUNCT
cusj-10288	435	5	england	england	PROPN
cusj-10288	435	6	)	)	PUNCT
cusj-10288	435	7	,	,	PUNCT
cusj-10288	435	8	369(9557	369(9557	NUM
cusj-10288	435	9	)	)	PUNCT
cusj-10288	435	10	,	,	PUNCT
cusj-10288	435	11	218–228	218–228	NUM
cusj-10288	435	12	.	.	PUNCT
cusj-10288	435	13	https://doi.org/10.1016/s01406736(07)60111-1	https://doi.org/10.1016/s01406736(07)60111-1	NOUN
cusj-10288	435	14	.	.	PUNCT
cusj-10288	436	1	[	[	X
cusj-10288	436	2	53	53	NUM
cusj-10288	436	3	]	]	PUNCT
cusj-10288	436	4	koutsis	koutsis	NOUN
cusj-10288	436	5	g	g	PROPN
cusj-10288	436	6	,	,	PUNCT
cusj-10288	436	7	karadima	karadima	PROPN
cusj-10288	436	8	g	g	PROPN
cusj-10288	436	9	,	,	PUNCT
cusj-10288	436	10	kladi	kladi	PROPN
cusj-10288	436	11	a	a	NOUN
cusj-10288	436	12	,	,	PUNCT
cusj-10288	436	13	et	et	PROPN
cusj-10288	436	14	al	al	PROPN
cusj-10288	436	15	.	.	PROPN
cusj-10288	437	1	(	(	PUNCT
cusj-10288	437	2	2013	2013	NUM
cusj-10288	437	3	)	)	PUNCT
cusj-10288	437	4	.	.	PUNCT
cusj-10288	438	1	the	the	DET
cusj-10288	438	2	challenge	challenge	NOUN
cusj-10288	438	3	of	of	ADP
cusj-10288	438	4	juvenile	juvenile	ADJ
cusj-10288	438	5	huntington	huntington	PROPN
cusj-10288	438	6	disease	disease	NOUN
cusj-10288	438	7	:	:	PUNCT
cusj-10288	438	8	to	to	PART
cusj-10288	438	9	test	test	VERB
cusj-10288	438	10	or	or	CCONJ
cusj-10288	438	11	not	not	PART
cusj-10288	438	12	to	to	PART
cusj-10288	438	13	test	test	VERB
cusj-10288	438	14	.	.	PUNCT
cusj-10288	439	1	neurology	neurology	NOUN
cusj-10288	439	2	;	;	PUNCT
cusj-10288	439	3	80:990–96	80:990–96	NUM
cusj-10288	439	4	.	.	PUNCT
cusj-10288	440	1	[	[	X
cusj-10288	440	2	54	54	NUM
cusj-10288	440	3	]	]	X
cusj-10288	440	4	gusella	gusella	PROPN
cusj-10288	440	5	,	,	PUNCT
cusj-10288	440	6	j.	j.	PROPN
cusj-10288	440	7	f.	f.	PROPN
cusj-10288	440	8	,	,	PUNCT
cusj-10288	440	9	macdonald	macdonald	PROPN
cusj-10288	440	10	,	,	PUNCT
cusj-10288	440	11	m.	m.	PROPN
cusj-10288	440	12	e.	e.	PROPN
cusj-10288	440	13	,	,	PUNCT
cusj-10288	440	14	&	&	CCONJ
cusj-10288	440	15	lee	lee	PROPN
cusj-10288	440	16	,	,	PUNCT
cusj-10288	440	17	j.	j.	PROPN
cusj-10288	440	18	m.	m.	PROPN
cusj-10288	440	19	(	(	PUNCT
cusj-10288	440	20	2014	2014	NUM
cusj-10288	440	21	)	)	PUNCT
cusj-10288	440	22	.	.	PUNCT
cusj-10288	441	1	genetic	genetic	ADJ
cusj-10288	441	2	modifiers	modifier	NOUN
cusj-10288	441	3	of	of	ADP
cusj-10288	441	4	huntington	huntington	PROPN
cusj-10288	441	5	's	's	PART
cusj-10288	441	6	disease	disease	NOUN
cusj-10288	441	7	.	.	PUNCT
cusj-10288	442	1	movement	movement	NOUN
cusj-10288	442	2	disorders	disorder	NOUN
cusj-10288	442	3	:	:	PUNCT
cusj-10288	442	4	official	official	ADJ
cusj-10288	442	5	journal	journal	NOUN
cusj-10288	442	6	of	of	ADP
cusj-10288	442	7	the	the	DET
cusj-10288	442	8	movement	movement	NOUN
cusj-10288	442	9	disorder	disorder	NOUN
cusj-10288	442	10	society	society	NOUN
cusj-10288	442	11	,	,	PUNCT
cusj-10288	442	12	29(11	29(11	NUM
cusj-10288	442	13	)	)	PUNCT
cusj-10288	442	14	,	,	PUNCT
cusj-10288	442	15	1359–1365	1359–1365	NUM
cusj-10288	442	16	.	.	PUNCT
cusj-10288	443	1	https://doi.org/10.1002/mds.26001	https://doi.org/10.1002/mds.26001	NOUN
cusj-10288	443	2	.	.	PUNCT
cusj-10288	444	1	[	[	X
cusj-10288	444	2	55	55	NUM
cusj-10288	444	3	]	]	X
cusj-10288	444	4	hong	hong	PROPN
cusj-10288	444	5	,	,	PUNCT
cusj-10288	444	6	e.	e.	PROPN
cusj-10288	444	7	p.	p.	PROPN
cusj-10288	444	8	,	,	PUNCT
cusj-10288	444	9	macdonald	macdonald	PROPN
cusj-10288	444	10	,	,	PUNCT
cusj-10288	444	11	m.	m.	PROPN
cusj-10288	444	12	e.	e.	PROPN
cusj-10288	444	13	,	,	PUNCT
cusj-10288	444	14	wheeler	wheeler	NOUN
cusj-10288	444	15	,	,	PUNCT
cusj-10288	444	16	v.	v.	PROPN
cusj-10288	444	17	c.	c.	PROPN
cusj-10288	444	18	,	,	PUNCT
cusj-10288	444	19	jones	jones	PROPN
cusj-10288	444	20	,	,	PUNCT
cusj-10288	444	21	l.	l.	PROPN
cusj-10288	444	22	,	,	PUNCT
cusj-10288	444	23	holmans	holman	NOUN
cusj-10288	444	24	,	,	PUNCT
cusj-10288	444	25	p.	p.	NOUN
cusj-10288	444	26	,	,	PUNCT
cusj-10288	444	27	orth	orth	PROPN
cusj-10288	444	28	,	,	PUNCT
cusj-10288	444	29	m.	m.	NOUN
cusj-10288	444	30	,	,	PUNCT
cusj-10288	444	31	monckton	monckton	PROPN
cusj-10288	444	32	,	,	PUNCT
cusj-10288	444	33	d.	d.	PROPN
cusj-10288	444	34	g.	g.	PROPN
cusj-10288	444	35	,	,	PUNCT
cusj-10288	444	36	long	long	ADV
cusj-10288	444	37	,	,	PUNCT
cusj-10288	444	38	j.	j.	PROPN
cusj-10288	444	39	d.	d.	PROPN
cusj-10288	444	40	,	,	PUNCT
cusj-10288	444	41	kwak	kwak	PROPN
cusj-10288	444	42	,	,	PUNCT
cusj-10288	444	43	s.	s.	PROPN
cusj-10288	444	44	,	,	PUNCT
cusj-10288	444	45	gusella	gusella	PROPN
cusj-10288	444	46	,	,	PUNCT
cusj-10288	444	47	j.	j.	PROPN
cusj-10288	444	48	f.	f.	PROPN
cusj-10288	444	49	,	,	PUNCT
cusj-10288	444	50	&	&	CCONJ
cusj-10288	444	51	lee	lee	PROPN
cusj-10288	444	52	,	,	PUNCT
cusj-10288	444	53	j.	j.	PROPN
cusj-10288	444	54	m.	m.	PROPN
cusj-10288	444	55	(	(	PUNCT
cusj-10288	444	56	2021	2021	NUM
cusj-10288	444	57	)	)	PUNCT
cusj-10288	444	58	.	.	PUNCT
cusj-10288	445	1	huntington	huntington	PROPN
cusj-10288	445	2	's	's	PART
cusj-10288	445	3	disease	disease	NOUN
cusj-10288	445	4	pathogenesis	pathogenesis	NOUN
cusj-10288	445	5	:	:	PUNCT
cusj-10288	445	6	two	two	NUM
cusj-10288	445	7	sequential	sequential	ADJ
cusj-10288	445	8	components	component	NOUN
cusj-10288	445	9	.	.	PUNCT
cusj-10288	446	1	journal	journal	PROPN
cusj-10288	446	2	of	of	ADP
cusj-10288	446	3	huntington	huntington	PROPN
cusj-10288	446	4	's	's	PART
cusj-10288	446	5	disease	disease	NOUN
cusj-10288	446	6	,	,	PUNCT
cusj-10288	446	7	10(1	10(1	NUM
cusj-10288	446	8	)	)	PUNCT
cusj-10288	446	9	,	,	PUNCT
cusj-10288	446	10	35–51	35–51	NUM
cusj-10288	446	11	.	.	PUNCT
cusj-10288	447	1	https://doi.org/10.3233/jhd-200427	https://doi.org/10.3233/jhd-200427	NOUN
cusj-10288	447	2	.	.	PUNCT
cusj-10288	448	1	[	[	X
cusj-10288	448	2	56	56	NUM
cusj-10288	448	3	]	]	X
cusj-10288	448	4	lee	lee	PROPN
cusj-10288	448	5	,	,	PUNCT
cusj-10288	448	6	j.	j.	PROPN
cusj-10288	448	7	m.	m.	PROPN
cusj-10288	448	8	,	,	PUNCT
cusj-10288	448	9	ramos	ramos	PROPN
cusj-10288	448	10	,	,	PUNCT
cusj-10288	448	11	e.	e.	PROPN
cusj-10288	448	12	m.	m.	PROPN
cusj-10288	448	13	,	,	PUNCT
cusj-10288	448	14	lee	lee	PROPN
cusj-10288	448	15	,	,	PUNCT
cusj-10288	448	16	j.	j.	PROPN
cusj-10288	448	17	h.	h.	PROPN
cusj-10288	448	18	,	,	PUNCT
cusj-10288	448	19	gillis	gillis	PROPN
cusj-10288	448	20	,	,	PUNCT
cusj-10288	448	21	t.	t.	PROPN
cusj-10288	448	22	,	,	PUNCT
cusj-10288	448	23	mysore	mysore	PROPN
cusj-10288	448	24	,	,	PUNCT
cusj-10288	448	25	j.	j.	PROPN
cusj-10288	448	26	s.	s.	PROPN
cusj-10288	448	27	,	,	PUNCT
cusj-10288	448	28	hayden	hayden	PROPN
cusj-10288	448	29	,	,	PUNCT
cusj-10288	448	30	m.	m.	PROPN
cusj-10288	448	31	r.	r.	PROPN
cusj-10288	448	32	,	,	PUNCT
cusj-10288	448	33	warby	warby	PROPN
cusj-10288	448	34	,	,	PUNCT
cusj-10288	448	35	s.	s.	PROPN
cusj-10288	448	36	c.	c.	PROPN
cusj-10288	448	37	,	,	PUNCT
cusj-10288	448	38	morrison	morrison	PROPN
cusj-10288	448	39	,	,	PUNCT
cusj-10288	448	40	p.	p.	PROPN
cusj-10288	448	41	,	,	PUNCT
cusj-10288	448	42	nance	nance	NOUN
cusj-10288	448	43	,	,	PUNCT
cusj-10288	448	44	m.	m.	NOUN
cusj-10288	448	45	,	,	PUNCT
cusj-10288	448	46	ross	ross	PROPN
cusj-10288	448	47	,	,	PUNCT
cusj-10288	448	48	c.	c.	PROPN
cusj-10288	448	49	a.	a.	PROPN
cusj-10288	448	50	,	,	PUNCT
cusj-10288	448	51	margolis	margolis	PROPN
cusj-10288	448	52	,	,	PUNCT
cusj-10288	448	53	r.	r.	PROPN
cusj-10288	448	54	l.	l.	PROPN
cusj-10288	448	55	,	,	PUNCT
cusj-10288	448	56	squitieri	squitieri	PROPN
cusj-10288	448	57	,	,	PUNCT
cusj-10288	448	58	f.	f.	PROPN
cusj-10288	448	59	,	,	PUNCT
cusj-10288	448	60	orobello	orobello	PROPN
cusj-10288	448	61	,	,	PUNCT
cusj-10288	448	62	s.	s.	PROPN
cusj-10288	448	63	,	,	PUNCT
cusj-10288	448	64	di	di	NOUN
cusj-10288	448	65	donato	donato	PROPN
cusj-10288	448	66	,	,	PUNCT
cusj-10288	448	67	s.	s.	PROPN
cusj-10288	448	68	,	,	PUNCT
cusj-10288	448	69	gomez	gomez	PROPN
cusj-10288	448	70	-	-	PUNCT
cusj-10288	448	71	tortosa	tortosa	PROPN
cusj-10288	448	72	,	,	PUNCT
cusj-10288	448	73	e.	e.	PROPN
cusj-10288	448	74	,	,	PUNCT
cusj-10288	448	75	ayuso	ayuso	PROPN
cusj-10288	448	76	,	,	PUNCT
cusj-10288	448	77	c.	c.	PROPN
cusj-10288	448	78	,	,	PUNCT
cusj-10288	448	79	suchowersky	suchowersky	NOUN
cusj-10288	448	80	,	,	PUNCT
cusj-10288	448	81	o.	o.	NOUN
cusj-10288	448	82	,	,	PUNCT
cusj-10288	448	83	trent	trent	NOUN
cusj-10288	448	84	,	,	PUNCT
cusj-10288	448	85	r.	r.	PROPN
cusj-10288	448	86	j.	j.	PROPN
cusj-10288	448	87	,	,	PUNCT
cusj-10288	448	88	mccusker	mccusker	PROPN
cusj-10288	448	89	,	,	PUNCT
cusj-10288	448	90	e.	e.	PROPN
cusj-10288	448	91	,	,	PUNCT
cusj-10288	448	92	novelletto	novelletto	NOUN
cusj-10288	448	93	,	,	PUNCT
cusj-10288	448	94	a.	a.	NOUN
cusj-10288	448	95	,	,	PUNCT
cusj-10288	448	96	…	…	PUNCT
cusj-10288	448	97	cohort	cohort	NOUN
cusj-10288	448	98	study	study	NOUN
cusj-10288	448	99	of	of	ADP
cusj-10288	448	100	the	the	DET
cusj-10288	448	101	hsg	hsg	NOUN
cusj-10288	448	102	(	(	PUNCT
cusj-10288	448	103	2012	2012	NUM
cusj-10288	448	104	)	)	PUNCT
cusj-10288	448	105	.	.	PUNCT
cusj-10288	449	1	cag	cag	PROPN
cusj-10288	449	2	repeat	repeat	VERB
cusj-10288	449	3	expansion	expansion	NOUN
cusj-10288	449	4	in	in	ADP
cusj-10288	449	5	huntington	huntington	PROPN
cusj-10288	449	6	disease	disease	NOUN
cusj-10288	449	7	determines	determine	VERB
cusj-10288	449	8	age	age	NOUN
cusj-10288	449	9	at	at	ADP
cusj-10288	449	10	onset	onset	NOUN
cusj-10288	449	11	in	in	ADP
cusj-10288	449	12	a	a	DET
cusj-10288	449	13	fully	fully	ADV
cusj-10288	449	14	dominant	dominant	ADJ
cusj-10288	449	15	fashion	fashion	NOUN
cusj-10288	449	16	.	.	PUNCT
cusj-10288	450	1	neurology	neurology	NOUN
cusj-10288	450	2	,	,	PUNCT
cusj-10288	450	3	78(10	78(10	NUM
cusj-10288	450	4	)	)	PUNCT
cusj-10288	450	5	,	,	PUNCT
cusj-10288	450	6	690–695	690–695	NUM
cusj-10288	450	7	.	.	PUNCT
cusj-10288	451	1	https://doi.org/10.1212/wnl.0b013e318249f	https://doi.org/10.1212/wnl.0b013e318249f	NOUN
cusj-10288	451	2	683	683	NUM
cusj-10288	451	3	.	.	PUNCT
cusj-10288	452	1	[	[	X
cusj-10288	452	2	57	57	NUM
cusj-10288	452	3	]	]	X
cusj-10288	452	4	genetic	genetic	ADJ
cusj-10288	452	5	modifiers	modifier	NOUN
cusj-10288	452	6	of	of	ADP
cusj-10288	452	7	huntington	huntington	PROPN
cusj-10288	452	8	’s	’s	PART
cusj-10288	452	9	disease	disease	NOUN
cusj-10288	452	10	(	(	PUNCT
cusj-10288	452	11	gem	gem	NOUN
cusj-10288	452	12	-	-	PUNCT
cusj-10288	452	13	hd	hd	NOUN
cusj-10288	452	14	)	)	PUNCT
cusj-10288	452	15	consortium	consortium	NOUN
cusj-10288	452	16	(	(	PUNCT
cusj-10288	452	17	2015	2015	NUM
cusj-10288	452	18	)	)	PUNCT
cusj-10288	452	19	.	.	PUNCT
cusj-10288	453	1	identification	identification	NOUN
cusj-10288	453	2	of	of	ADP
cusj-10288	453	3	genetic	genetic	ADJ
cusj-10288	453	4	factors	factor	NOUN
cusj-10288	453	5	that	that	PRON
cusj-10288	453	6	modify	modify	VERB
cusj-10288	453	7	clinical	clinical	ADJ
cusj-10288	453	8	onset	onset	NOUN
cusj-10288	453	9	of	of	ADP
cusj-10288	453	10	huntington	huntington	PROPN
cusj-10288	453	11	's	's	PART
cusj-10288	453	12	disease	disease	NOUN
cusj-10288	453	13	.	.	PUNCT
cusj-10288	454	1	cell	cell	NOUN
cusj-10288	454	2	,	,	PUNCT
cusj-10288	454	3	162(3	162(3	NUM
cusj-10288	454	4	)	)	PUNCT
cusj-10288	454	5	,	,	PUNCT
cusj-10288	454	6	516–526	516–526	NUM
cusj-10288	454	7	.	.	PUNCT
cusj-10288	455	1	https://doi.org/10.1016/j.cell.2015.07.003	https://doi.org/10.1016/j.cell.2015.07.003	ADJ
cusj-10288	455	2	.	.	PUNCT
cusj-10288	456	1	[	[	X
cusj-10288	456	2	58	58	NUM
cusj-10288	456	3	]	]	X
cusj-10288	456	4	lee	lee	PROPN
cusj-10288	456	5	,	,	PUNCT
cusj-10288	456	6	j.	j.	PROPN
cusj-10288	456	7	m.	m.	PROPN
cusj-10288	456	8	,	,	PUNCT
cusj-10288	456	9	gillis	gillis	PROPN
cusj-10288	456	10	,	,	PUNCT
cusj-10288	456	11	t.	t.	PROPN
cusj-10288	456	12	,	,	PUNCT
cusj-10288	456	13	mysore	mysore	PROPN
cusj-10288	456	14	,	,	PUNCT
cusj-10288	456	15	j.	j.	PROPN
cusj-10288	456	16	s.	s.	PROPN
cusj-10288	456	17	,	,	PUNCT
cusj-10288	456	18	ramos	ramos	PROPN
cusj-10288	456	19	,	,	PUNCT
cusj-10288	456	20	e.	e.	PROPN
cusj-10288	456	21	m.	m.	PROPN
cusj-10288	456	22	,	,	PUNCT
cusj-10288	456	23	myers	myers	PROPN
cusj-10288	456	24	,	,	PUNCT
cusj-10288	456	25	r.	r.	PROPN
cusj-10288	456	26	h.	h.	PROPN
cusj-10288	456	27	,	,	PUNCT
cusj-10288	456	28	hayden	hayden	PROPN
cusj-10288	456	29	,	,	PUNCT
cusj-10288	456	30	m.	m.	PROPN
cusj-10288	456	31	r.	r.	PROPN
cusj-10288	456	32	,	,	PUNCT
cusj-10288	456	33	morrison	morrison	PROPN
cusj-10288	456	34	,	,	PUNCT
cusj-10288	456	35	p.	p.	PROPN
cusj-10288	456	36	j.	j.	PROPN
cusj-10288	456	37	,	,	PUNCT
cusj-10288	456	38	nance	nance	NOUN
cusj-10288	456	39	,	,	PUNCT
cusj-10288	456	40	m.	m.	NOUN
cusj-10288	456	41	,	,	PUNCT
cusj-10288	456	42	ross	ross	PROPN
cusj-10288	456	43	,	,	PUNCT
cusj-10288	456	44	c.	c.	PROPN
cusj-10288	456	45	a.	a.	PROPN
cusj-10288	456	46	,	,	PUNCT
cusj-10288	456	47	margolis	margolis	PROPN
cusj-10288	456	48	,	,	PUNCT
cusj-10288	456	49	r.	r.	PROPN
cusj-10288	456	50	l.	l.	PROPN
cusj-10288	456	51	,	,	PUNCT
cusj-10288	456	52	squitieri	squitieri	PROPN
cusj-10288	456	53	,	,	PUNCT
cusj-10288	456	54	f.	f.	PROPN
cusj-10288	456	55	,	,	PUNCT
cusj-10288	456	56	griguoli	griguoli	NOUN
cusj-10288	456	57	,	,	PUNCT
cusj-10288	456	58	a.	a.	NOUN
cusj-10288	456	59	,	,	PUNCT
cusj-10288	456	60	di	di	NOUN
cusj-10288	456	61	donato	donato	PROPN
cusj-10288	456	62	,	,	PUNCT
cusj-10288	456	63	s.	s.	PROPN
cusj-10288	456	64	,	,	PUNCT
cusj-10288	456	65	gomez	gomez	PROPN
cusj-10288	456	66	-	-	PUNCT
cusj-10288	456	67	tortosa	tortosa	PROPN
cusj-10288	456	68	,	,	PUNCT
cusj-10288	456	69	e.	e.	PROPN
cusj-10288	456	70	,	,	PUNCT
cusj-10288	456	71	ayuso	ayuso	PROPN
cusj-10288	456	72	,	,	PUNCT
cusj-10288	456	73	c.	c.	PROPN
cusj-10288	456	74	,	,	PUNCT
cusj-10288	456	75	suchowersky	suchowersky	NOUN
cusj-10288	456	76	,	,	PUNCT
cusj-10288	456	77	o.	o.	NOUN
cusj-10288	456	78	,	,	PUNCT
cusj-10288	456	79	trent	trent	NOUN
cusj-10288	456	80	,	,	PUNCT
cusj-10288	456	81	r.	r.	PROPN
cusj-10288	456	82	j.	j.	PROPN
cusj-10288	456	83	,	,	PUNCT
cusj-10288	456	84	mccusker	mccusker	PROPN
cusj-10288	456	85	,	,	PUNCT
cusj-10288	456	86	e.	e.	PROPN
cusj-10288	456	87	,	,	PUNCT
cusj-10288	456	88	novelletto	novelletto	NOUN
cusj-10288	456	89	,	,	PUNCT
cusj-10288	456	90	a.	a.	NOUN
cusj-10288	456	91	,	,	PUNCT
cusj-10288	456	92	frontali	frontali	ADJ
cusj-10288	456	93	,	,	PUNCT
cusj-10288	456	94	m.	m.	NOUN
cusj-10288	456	95	,	,	PUNCT
cusj-10288	456	96	…	…	PUNCT
cusj-10288	456	97	gusella	gusella	X
cusj-10288	456	98	,	,	PUNCT
cusj-10288	456	99	j.	j.	PROPN
cusj-10288	456	100	f.	f.	PROPN
cusj-10288	456	101	(	(	PUNCT
cusj-10288	456	102	2012	2012	NUM
cusj-10288	456	103	)	)	PUNCT
cusj-10288	456	104	.	.	PUNCT
cusj-10288	457	1	common	common	ADJ
cusj-10288	457	2	snp	snp	VERB
cusj-10288	457	3	-	-	PUNCT
cusj-10288	457	4	based	base	VERB
cusj-10288	457	5	haplotype	haplotype	NOUN
cusj-10288	457	6	analysis	analysis	NOUN
cusj-10288	457	7	of	of	ADP
cusj-10288	457	8	the	the	DET
cusj-10288	457	9	4p16.3	4p16.3	PROPN
cusj-10288	457	10	huntington	huntington	PROPN
cusj-10288	457	11	disease	disease	PROPN
cusj-10288	457	12	gene	gene	NOUN
cusj-10288	457	13	region	region	NOUN
cusj-10288	457	14	.	.	PUNCT
cusj-10288	458	1	american	american	PROPN
cusj-10288	458	2	journal	journal	PROPN
cusj-10288	458	3	of	of	ADP
cusj-10288	458	4	human	human	ADJ
cusj-10288	458	5	genetics	genetic	NOUN
cusj-10288	458	6	,	,	PUNCT
cusj-10288	458	7	90(3	90(3	NOUN
cusj-10288	458	8	)	)	PUNCT
cusj-10288	458	9	,	,	PUNCT
cusj-10288	458	10	434–444	434–444	NUM
cusj-10288	458	11	.	.	PUNCT
cusj-10288	459	1	https://doi.org/10.1016/j.ajhg.2012.01.005	https://doi.org/10.1016/j.ajhg.2012.01.005	ADJ
cusj-10288	459	2	.	.	PUNCT
cusj-10288	460	1	[	[	X
cusj-10288	460	2	59	59	NUM
cusj-10288	460	3	]	]	SYM
cusj-10288	460	4	quintanilla	quintanilla	PROPN
cusj-10288	460	5	,	,	PUNCT
cusj-10288	460	6	r.	r.	PROPN
cusj-10288	460	7	a.	a.	PROPN
cusj-10288	460	8	,	,	PUNCT
cusj-10288	460	9	&	&	CCONJ
cusj-10288	460	10	johnson	johnson	PROPN
cusj-10288	460	11	,	,	PUNCT
cusj-10288	460	12	g.	g.	PROPN
cusj-10288	460	13	v.	v.	PROPN
cusj-10288	460	14	(	(	PUNCT
cusj-10288	460	15	2009	2009	NUM
cusj-10288	460	16	)	)	PUNCT
cusj-10288	460	17	.	.	PUNCT
cusj-10288	461	1	role	role	NOUN
cusj-10288	461	2	of	of	ADP
cusj-10288	461	3	mitochondrial	mitochondrial	ADJ
cusj-10288	461	4	dysfunction	dysfunction	NOUN
cusj-10288	461	5	in	in	ADP
cusj-10288	461	6	the	the	DET
cusj-10288	461	7	pathogenesis	pathogenesis	NOUN
cusj-10288	461	8	of	of	ADP
cusj-10288	461	9	huntington	huntington	PROPN
cusj-10288	461	10	's	's	PART
cusj-10288	461	11	disease	disease	NOUN
cusj-10288	461	12	.	.	PUNCT
cusj-10288	462	1	brain	brain	NOUN
cusj-10288	462	2	research	research	PROPN
cusj-10288	462	3	bulletin	bulletin	NOUN
cusj-10288	462	4	,	,	PUNCT
cusj-10288	462	5	80(4	80(4	NUM
cusj-10288	462	6	-	-	SYM
cusj-10288	462	7	5	5	NUM
cusj-10288	462	8	)	)	PUNCT
cusj-10288	462	9	,	,	PUNCT
cusj-10288	462	10	242–247	242–247	NUM
cusj-10288	462	11	.	.	PUNCT
cusj-10288	463	1	https://doi.org/10.1016/j.brainresbull.2009.07	https://doi.org/10.1016/j.brainresbull.2009.07	PROPN
cusj-10288	463	2	.010	.010	NUM
cusj-10288	463	3	.	.	PUNCT
cusj-10288	464	1	[	[	X
cusj-10288	464	2	60	60	NUM
cusj-10288	464	3	]	]	X
cusj-10288	464	4	chen	chen	PROPN
cusj-10288	464	5	c.	c.	PROPN
cusj-10288	464	6	m.	m.	PROPN
cusj-10288	464	7	(	(	PUNCT
cusj-10288	464	8	2011	2011	NUM
cusj-10288	464	9	)	)	PUNCT
cusj-10288	464	10	.	.	PUNCT
cusj-10288	465	1	mitochondrial	mitochondrial	ADJ
cusj-10288	465	2	dysfunction	dysfunction	NOUN
cusj-10288	465	3	,	,	PUNCT
cusj-10288	465	4	metabolic	metabolic	NOUN
cusj-10288	465	5	deficits	deficit	NOUN
cusj-10288	465	6	,	,	PUNCT
cusj-10288	465	7	and	and	CCONJ
cusj-10288	465	8	increased	increase	VERB
cusj-10288	465	9	oxidative	oxidative	ADJ
cusj-10288	465	10	stress	stress	NOUN
cusj-10288	465	11	in	in	ADP
cusj-10288	465	12	huntington	huntington	PROPN
cusj-10288	465	13	's	's	PART
cusj-10288	465	14	disease	disease	NOUN
cusj-10288	465	15	.	.	PUNCT
cusj-10288	466	1	chang	chang	PROPN
cusj-10288	466	2	gung	gung	PROPN
cusj-10288	466	3	medical	medical	PROPN
cusj-10288	466	4	journal	journal	PROPN
cusj-10288	466	5	,	,	PUNCT
cusj-10288	466	6	34(2	34(2	NUM
cusj-10288	466	7	)	)	PUNCT
cusj-10288	466	8	,	,	PUNCT
cusj-10288	466	9	135	135	NUM
cusj-10288	466	10	–	–	PUNCT
cusj-10288	466	11	152	152	NUM
cusj-10288	466	12	.	.	PUNCT
cusj-10288	467	1	[	[	X
cusj-10288	467	2	61	61	NUM
cusj-10288	467	3	]	]	PUNCT
cusj-10288	467	4	friedlander	friedlander	PROPN
cusj-10288	467	5	r.	r.	PROPN
cusj-10288	467	6	m.	m.	PROPN
cusj-10288	467	7	(	(	PUNCT
cusj-10288	467	8	2003	2003	NUM
cusj-10288	467	9	)	)	PUNCT
cusj-10288	467	10	.	.	PUNCT
cusj-10288	468	1	apoptosis	apoptosis	NOUN
cusj-10288	468	2	and	and	CCONJ
cusj-10288	468	3	caspases	caspase	NOUN
cusj-10288	468	4	in	in	ADP
cusj-10288	468	5	neurodegenerative	neurodegenerative	ADJ
cusj-10288	468	6	diseases	disease	NOUN
cusj-10288	468	7	.	.	PUNCT
cusj-10288	469	1	the	the	DET
cusj-10288	469	2	new	new	PROPN
cusj-10288	469	3	england	england	PROPN
cusj-10288	469	4	journal	journal	PROPN
cusj-10288	469	5	of	of	ADP
cusj-10288	469	6	medicine	medicine	NOUN
cusj-10288	469	7	,	,	PUNCT
cusj-10288	469	8	348(14	348(14	NUM
cusj-10288	469	9	)	)	PUNCT
cusj-10288	469	10	,	,	PUNCT
cusj-10288	469	11	1365–1375	1365–1375	NUM
cusj-10288	469	12	.	.	PUNCT
cusj-10288	470	1	https://doi.org/10.1056/nejmra022366	https://doi.org/10.1056/nejmra022366	VERB
cusj-10288	470	2	.	.	PUNCT
cusj-10288	471	1	[	[	X
cusj-10288	471	2	62	62	NUM
cusj-10288	471	3	]	]	PUNCT
cusj-10288	471	4	leegwater	leegwater	PROPN
cusj-10288	471	5	-	-	PUNCT
cusj-10288	471	6	kim	kim	PROPN
cusj-10288	471	7	,	,	PUNCT
cusj-10288	471	8	j.	j.	PROPN
cusj-10288	471	9	,	,	PUNCT
cusj-10288	471	10	&	&	CCONJ
cusj-10288	471	11	cha	cha	PROPN
cusj-10288	471	12	,	,	PUNCT
cusj-10288	471	13	j.	j.	PROPN
cusj-10288	471	14	h.	h.	PROPN
cusj-10288	471	15	(	(	PUNCT
cusj-10288	471	16	2004	2004	NUM
cusj-10288	471	17	)	)	PUNCT
cusj-10288	471	18	.	.	PUNCT
cusj-10288	472	1	the	the	DET
cusj-10288	472	2	paradigm	paradigm	NOUN
cusj-10288	472	3	of	of	ADP
cusj-10288	472	4	huntington	huntington	PROPN
cusj-10288	472	5	's	's	PART
cusj-10288	472	6	disease	disease	NOUN
cusj-10288	472	7	:	:	PUNCT
cusj-10288	472	8	therapeutic	therapeutic	ADJ
cusj-10288	472	9	opportunities	opportunity	NOUN
cusj-10288	472	10	in	in	ADP
cusj-10288	472	11	neurodegeneration	neurodegeneration	NOUN
cusj-10288	472	12	.	.	PUNCT
cusj-10288	473	1	neurorx	neurorx	PROPN
cusj-10288	473	2	:	:	PUNCT
cusj-10288	473	3	the	the	DET
cusj-10288	473	4	journal	journal	NOUN
cusj-10288	473	5	of	of	ADP
cusj-10288	473	6	the	the	DET
cusj-10288	473	7	american	american	ADJ
cusj-10288	473	8	society	society	NOUN
cusj-10288	473	9	for	for	ADP
cusj-10288	473	10	experimental	experimental	ADJ
cusj-10288	473	11	neurotherapeutics	neurotherapeutic	NOUN
cusj-10288	473	12	,	,	PUNCT
cusj-10288	473	13	1(1	1(1	NUM
cusj-10288	473	14	)	)	PUNCT
cusj-10288	473	15	,	,	PUNCT
cusj-10288	473	16	columbia	columbia	PROPN
cusj-10288	473	17	undergraduate	undergraduate	PROPN
cusj-10288	473	18	science	science	PROPN
cusj-10288	473	19	journal	journal	PROPN
cusj-10288	473	20	vol	vol	NOUN
cusj-10288	473	21	.	.	PROPN
cusj-10288	473	22	17	17	NUM
cusj-10288	473	23	,	,	PUNCT
cusj-10288	473	24	2023	2023	NUM
cusj-10288	473	25	datta	datta	NOUN
cusj-10288	473	26	32	32	NUM
cusj-10288	473	27	128–138	128–138	NUM
cusj-10288	473	28	.	.	PUNCT
cusj-10288	474	1	https://doi.org/10.1602/neurorx.1.1.128	https://doi.org/10.1602/neurorx.1.1.128	NOUN
cusj-10288	474	2	.	.	PUNCT
cusj-10288	475	1	[	[	X
cusj-10288	475	2	63	63	NUM
cusj-10288	475	3	]	]	SYM
cusj-10288	475	4	li	li	PROPN
cusj-10288	475	5	,	,	PUNCT
cusj-10288	475	6	s.	s.	PROPN
cusj-10288	475	7	h.	h.	PROPN
cusj-10288	475	8	,	,	PUNCT
cusj-10288	475	9	lam	lam	PROPN
cusj-10288	475	10	,	,	PUNCT
cusj-10288	475	11	s.	s.	PROPN
cusj-10288	475	12	,	,	PUNCT
cusj-10288	475	13	cheng	cheng	PROPN
cusj-10288	475	14	,	,	PUNCT
cusj-10288	475	15	a.	a.	PROPN
cusj-10288	475	16	l.	l.	PROPN
cusj-10288	475	17	,	,	PUNCT
cusj-10288	475	18	&	&	CCONJ
cusj-10288	475	19	li	li	PROPN
cusj-10288	475	20	,	,	PUNCT
cusj-10288	475	21	x.	x.	PROPN
cusj-10288	475	22	j.	j.	PROPN
cusj-10288	475	23	(	(	PUNCT
cusj-10288	475	24	2000	2000	NUM
cusj-10288	475	25	)	)	PUNCT
cusj-10288	475	26	.	.	PUNCT
cusj-10288	476	1	intranuclear	intranuclear	NOUN
cusj-10288	476	2	huntingtin	huntingtin	PROPN
cusj-10288	476	3	increases	increase	VERB
cusj-10288	476	4	the	the	DET
cusj-10288	476	5	expression	expression	NOUN
cusj-10288	476	6	of	of	ADP
cusj-10288	476	7	caspase-1	caspase-1	NOUN
cusj-10288	476	8	and	and	CCONJ
cusj-10288	476	9	induces	induce	VERB
cusj-10288	476	10	apoptosis	apoptosis	NOUN
cusj-10288	476	11	.	.	PUNCT
cusj-10288	477	1	human	human	ADJ
cusj-10288	477	2	molecular	molecular	ADJ
cusj-10288	477	3	genetics	genetic	NOUN
cusj-10288	477	4	,	,	PUNCT
cusj-10288	477	5	9(19	9(19	NUM
cusj-10288	477	6	)	)	PUNCT
cusj-10288	477	7	,	,	PUNCT
cusj-10288	477	8	2859–2867	2859–2867	NUM
cusj-10288	477	9	.	.	PUNCT
cusj-10288	477	10	https://doi.org/10.1093/hmg/9.19.2859	https://doi.org/10.1093/hmg/9.19.2859	NOUN
cusj-10288	477	11	.	.	PUNCT
cusj-10288	478	1	[	[	X
cusj-10288	478	2	64	64	NUM
cusj-10288	478	3	]	]	X
cusj-10288	478	4	kalonia	kalonia	PROPN
cusj-10288	478	5	,	,	PUNCT
cusj-10288	478	6	h.	h.	PROPN
cusj-10288	478	7	,	,	PUNCT
cusj-10288	478	8	kumar	kumar	PROPN
cusj-10288	478	9	,	,	PUNCT
cusj-10288	478	10	p.	p.	PROPN
cusj-10288	478	11	,	,	PUNCT
cusj-10288	478	12	&	&	CCONJ
cusj-10288	478	13	kumar	kumar	PROPN
cusj-10288	478	14	,	,	PUNCT
cusj-10288	478	15	a.	a.	NOUN
cusj-10288	478	16	(	(	PUNCT
cusj-10288	478	17	2011	2011	NUM
cusj-10288	478	18	)	)	PUNCT
cusj-10288	478	19	.	.	PUNCT
cusj-10288	479	1	attenuation	attenuation	NOUN
cusj-10288	479	2	of	of	ADP
cusj-10288	479	3	proinflammatory	proinflammatory	ADJ
cusj-10288	479	4	cytokines	cytokine	NOUN
cusj-10288	479	5	and	and	CCONJ
cusj-10288	479	6	apoptotic	apoptotic	ADJ
cusj-10288	479	7	process	process	NOUN
cusj-10288	479	8	by	by	ADP
cusj-10288	479	9	verapamil	verapamil	NOUN
cusj-10288	479	10	and	and	CCONJ
cusj-10288	479	11	diltiazem	diltiazem	NOUN
cusj-10288	479	12	against	against	ADP
cusj-10288	479	13	quinolinic	quinolinic	ADJ
cusj-10288	479	14	acid	acid	NOUN
cusj-10288	479	15	induced	induce	VERB
cusj-10288	479	16	huntington	huntington	PROPN
cusj-10288	479	17	like	like	ADP
cusj-10288	479	18	alterations	alteration	NOUN
cusj-10288	479	19	in	in	ADP
cusj-10288	479	20	rats	rat	NOUN
cusj-10288	479	21	.	.	PUNCT
cusj-10288	480	1	brain	brain	NOUN
cusj-10288	480	2	research	research	NOUN
cusj-10288	480	3	,	,	PUNCT
cusj-10288	480	4	1372	1372	NUM
cusj-10288	480	5	,	,	PUNCT
cusj-10288	480	6	115–126	115–126	NUM
cusj-10288	480	7	.	.	PUNCT
cusj-10288	480	8	https://doi.org/10.1016/j.brainres.2010.11.06	https://doi.org/10.1016/j.brainres.2010.11.06	NOUN
cusj-10288	480	9	0	0	NUM
cusj-10288	480	10	.	.	PUNCT
cusj-10288	481	1	[	[	X
cusj-10288	481	2	65	65	NUM
cusj-10288	481	3	]	]	X
cusj-10288	481	4	difiglia	difiglia	PROPN
cusj-10288	481	5	m.	m.	NOUN
cusj-10288	481	6	(	(	PUNCT
cusj-10288	481	7	1990	1990	NUM
cusj-10288	481	8	)	)	PUNCT
cusj-10288	481	9	.	.	PUNCT
cusj-10288	482	1	excitotoxic	excitotoxic	ADJ
cusj-10288	482	2	injury	injury	NOUN
cusj-10288	482	3	of	of	ADP
cusj-10288	482	4	the	the	DET
cusj-10288	482	5	neostriatum	neostriatum	NOUN
cusj-10288	482	6	:	:	PUNCT
cusj-10288	482	7	a	a	DET
cusj-10288	482	8	model	model	NOUN
cusj-10288	482	9	for	for	ADP
cusj-10288	482	10	huntington	huntington	PROPN
cusj-10288	482	11	's	's	PART
cusj-10288	482	12	disease	disease	NOUN
cusj-10288	482	13	.	.	PUNCT
cusj-10288	483	1	trends	trend	NOUN
cusj-10288	483	2	in	in	ADP
cusj-10288	483	3	neurosciences	neuroscience	NOUN
cusj-10288	483	4	,	,	PUNCT
cusj-10288	483	5	13(7	13(7	NUM
cusj-10288	483	6	)	)	PUNCT
cusj-10288	483	7	,	,	PUNCT
cusj-10288	483	8	286–289	286–289	NUM
cusj-10288	483	9	.	.	PUNCT
cusj-10288	483	10	https://doi.org/10.1016/01662236(90)90111-m	https://doi.org/10.1016/01662236(90)90111-m	NOUN
cusj-10288	483	11	.	.	PUNCT
cusj-10288	484	1	[	[	X
cusj-10288	484	2	66	66	NUM
cusj-10288	484	3	]	]	PUNCT
cusj-10288	484	4	jamwal	jamwal	NOUN
cusj-10288	484	5	,	,	PUNCT
cusj-10288	484	6	s.	s.	PROPN
cusj-10288	484	7	,	,	PUNCT
cusj-10288	484	8	&	&	CCONJ
cusj-10288	484	9	kumar	kumar	PROPN
cusj-10288	484	10	,	,	PUNCT
cusj-10288	484	11	p.	p.	NOUN
cusj-10288	484	12	(	(	PUNCT
cusj-10288	484	13	2015	2015	NUM
cusj-10288	484	14	)	)	PUNCT
cusj-10288	484	15	.	.	PUNCT
cusj-10288	485	1	antidepressants	antidepressant	NOUN
cusj-10288	485	2	for	for	ADP
cusj-10288	485	3	neuroprotection	neuroprotection	NOUN
cusj-10288	485	4	in	in	ADP
cusj-10288	485	5	huntington	huntington	PROPN
cusj-10288	485	6	's	's	PART
cusj-10288	485	7	disease	disease	NOUN
cusj-10288	485	8	:	:	PUNCT
cusj-10288	485	9	a	a	DET
cusj-10288	485	10	review	review	NOUN
cusj-10288	485	11	.	.	PUNCT
cusj-10288	486	1	european	european	PROPN
cusj-10288	486	2	journal	journal	PROPN
cusj-10288	486	3	of	of	ADP
cusj-10288	486	4	pharmacology	pharmacology	NOUN
cusj-10288	486	5	,	,	PUNCT
cusj-10288	486	6	769	769	NUM
cusj-10288	486	7	,	,	PUNCT
cusj-10288	486	8	33–42	33–42	NUM
cusj-10288	486	9	.	.	PUNCT
cusj-10288	486	10	https://doi.org/10.1016/j.ejphar.2015.10.033	https://doi.org/10.1016/j.ejphar.2015.10.033	PROPN
cusj-10288	486	11	.	.	PUNCT
cusj-10288	487	1	[	[	X
cusj-10288	487	2	67	67	NUM
cusj-10288	487	3	]	]	PUNCT
cusj-10288	487	4	palaiogeorgou	palaiogeorgou	PROPN
cusj-10288	487	5	,	,	PUNCT
cusj-10288	487	6	a.m.	a.m.	ADV
cusj-10288	487	7	,	,	PUNCT
cusj-10288	487	8	papakonstantinou	papakonstantinou	PROPN
cusj-10288	487	9	,	,	PUNCT
cusj-10288	487	10	e.	e.	PROPN
cusj-10288	487	11	,	,	PUNCT
cusj-10288	487	12	golfinopoulou	golfinopoulou	PROPN
cusj-10288	487	13	,	,	PUNCT
cusj-10288	487	14	r.	r.	PROPN
cusj-10288	487	15	,	,	PUNCT
cusj-10288	487	16	sigala	sigala	NOUN
cusj-10288	487	17	,	,	PUNCT
cusj-10288	487	18	m.	m.	NOUN
cusj-10288	487	19	,	,	PUNCT
cusj-10288	487	20	mitsis	mitsis	NOUN
cusj-10288	487	21	,	,	PUNCT
cusj-10288	487	22	t.	t.	PROPN
cusj-10288	487	23	,	,	PUNCT
cusj-10288	487	24	papageorgiou	papageorgiou	PROPN
cusj-10288	487	25	,	,	PUNCT
cusj-10288	487	26	l.	l.	PROPN
cusj-10288	487	27	...	...	PUNCT
cusj-10288	487	28	vlachakis	vlachaki	NOUN
cusj-10288	487	29	,	,	PUNCT
cusj-10288	487	30	d.	d.	PROPN
cusj-10288	487	31	(	(	PUNCT
cusj-10288	487	32	2023	2023	NUM
cusj-10288	487	33	)	)	PUNCT
cusj-10288	487	34	.	.	PUNCT
cusj-10288	488	1	recent	recent	ADJ
cusj-10288	488	2	approaches	approach	NOUN
cusj-10288	488	3	on	on	ADP
cusj-10288	488	4	huntington	huntington	PROPN
cusj-10288	488	5	's	's	PART
cusj-10288	488	6	disease	disease	NOUN
cusj-10288	488	7	(	(	PUNCT
cusj-10288	488	8	review	review	NOUN
cusj-10288	488	9	)	)	PUNCT
cusj-10288	488	10	.	.	PUNCT
cusj-10288	489	1	biomedical	biomedical	ADJ
cusj-10288	489	2	reports	report	NOUN
cusj-10288	489	3	,	,	PUNCT
cusj-10288	489	4	18	18	NUM
cusj-10288	489	5	,	,	PUNCT
cusj-10288	489	6	5	5	NUM
cusj-10288	489	7	.	.	PUNCT
cusj-10288	489	8	https://doi.org/10.3892/br.2022.1587	https://doi.org/10.3892/br.2022.1587	ADJ
cusj-10288	490	1	[	[	X
cusj-10288	490	2	68	68	NUM
cusj-10288	490	3	]	]	X
cusj-10288	490	4	barker	barker	PROPN
cusj-10288	490	5	,	,	PUNCT
cusj-10288	490	6	r.	r.	PROPN
cusj-10288	490	7	a.	a.	PROPN
cusj-10288	490	8	,	,	PUNCT
cusj-10288	490	9	fujimaki	fujimaki	NOUN
cusj-10288	490	10	,	,	PUNCT
cusj-10288	490	11	m.	m.	NOUN
cusj-10288	490	12	,	,	PUNCT
cusj-10288	490	13	rogers	roger	NOUN
cusj-10288	490	14	,	,	PUNCT
cusj-10288	490	15	p.	p.	PROPN
cusj-10288	490	16	,	,	PUNCT
cusj-10288	490	17	&	&	CCONJ
cusj-10288	490	18	rubinsztein	rubinsztein	PROPN
cusj-10288	490	19	,	,	PUNCT
cusj-10288	490	20	d.	d.	PROPN
cusj-10288	490	21	c.	c.	PROPN
cusj-10288	490	22	(	(	PUNCT
cusj-10288	490	23	2020	2020	NUM
cusj-10288	490	24	)	)	PUNCT
cusj-10288	490	25	.	.	PUNCT
cusj-10288	491	1	huntingtinlowering	huntingtinlowere	VERB
cusj-10288	491	2	strategies	strategy	NOUN
cusj-10288	491	3	for	for	ADP
cusj-10288	491	4	huntington	huntington	PROPN
cusj-10288	491	5	's	's	PART
cusj-10288	491	6	disease	disease	NOUN
cusj-10288	491	7	.	.	PUNCT
cusj-10288	492	1	expert	expert	ADJ
cusj-10288	492	2	opinion	opinion	NOUN
cusj-10288	492	3	on	on	ADP
cusj-10288	492	4	investigational	investigational	ADJ
cusj-10288	492	5	drugs	drug	NOUN
cusj-10288	492	6	,	,	PUNCT
cusj-10288	492	7	29(10	29(10	NOUN
cusj-10288	492	8	)	)	PUNCT
cusj-10288	492	9	,	,	PUNCT
cusj-10288	492	10	1125–1132	1125–1132	NUM
cusj-10288	492	11	.	.	PUNCT
cusj-10288	493	1	https://doi.org/10.1080/13543784.2020.1804	https://doi.org/10.1080/13543784.2020.1804	NOUN
cusj-10288	493	2	552	552	NUM
cusj-10288	494	1	[	[	X
cusj-10288	494	2	69	69	NUM
cusj-10288	494	3	]	]	X
cusj-10288	494	4	aziz	aziz	PROPN
cusj-10288	494	5	,	,	PUNCT
cusj-10288	494	6	n.	n.	PROPN
cusj-10288	494	7	a.	a.	PROPN
cusj-10288	494	8	,	,	PUNCT
cusj-10288	494	9	van	van	PROPN
cusj-10288	494	10	der	der	PROPN
cusj-10288	494	11	burg	burg	PROPN
cusj-10288	494	12	,	,	PUNCT
cusj-10288	494	13	j.	j.	PROPN
cusj-10288	494	14	m.	m.	PROPN
cusj-10288	494	15	m.	m.	PROPN
cusj-10288	494	16	,	,	PUNCT
cusj-10288	494	17	tabrizi	tabrizi	NOUN
cusj-10288	494	18	,	,	PUNCT
cusj-10288	494	19	s.	s.	PROPN
cusj-10288	494	20	j.	j.	PROPN
cusj-10288	494	21	,	,	PUNCT
cusj-10288	494	22	&	&	CCONJ
cusj-10288	494	23	landwehrmeyer	landwehrmeyer	PROPN
cusj-10288	494	24	,	,	PUNCT
cusj-10288	494	25	g.	g.	PROPN
cusj-10288	494	26	b.	b.	PROPN
cusj-10288	494	27	(	(	PUNCT
cusj-10288	494	28	2018	2018	NUM
cusj-10288	494	29	)	)	PUNCT
cusj-10288	494	30	.	.	PUNCT
cusj-10288	495	1	overlap	overlap	NOUN
cusj-10288	495	2	between	between	ADP
cusj-10288	495	3	age	age	NOUN
cusj-10288	495	4	-	-	PUNCT
cusj-10288	495	5	at	at	ADP
cusj-10288	495	6	-	-	PUNCT
cusj-10288	495	7	onset	onset	VERB
cusj-10288	495	8	and	and	CCONJ
cusj-10288	495	9	diseaseprogression	diseaseprogression	NOUN
cusj-10288	495	10	determinants	determinant	NOUN
cusj-10288	495	11	in	in	ADP
cusj-10288	495	12	huntington	huntington	PROPN
cusj-10288	495	13	disease	disease	PROPN
cusj-10288	495	14	.	.	PUNCT
cusj-10288	496	1	neurology	neurology	NOUN
cusj-10288	496	2	,	,	PUNCT
cusj-10288	496	3	90(24	90(24	NUM
cusj-10288	496	4	)	)	PUNCT
cusj-10288	496	5	,	,	PUNCT
cusj-10288	496	6	e2099	e2099	PROPN
cusj-10288	496	7	–	–	PUNCT
cusj-10288	496	8	e2106	e2106	NOUN
cusj-10288	496	9	.	.	PUNCT
cusj-10288	497	1	https://doi.org/10.1212/wnl.0000000000005	https://doi.org/10.1212/wnl.0000000000005	VERB
cusj-10288	497	2	690	690	NUM
cusj-10288	498	1	[	[	X
cusj-10288	498	2	70	70	NUM
cusj-10288	498	3	]	]	PUNCT
cusj-10288	498	4	tabrizi	tabrizi	NOUN
cusj-10288	498	5	,	,	PUNCT
cusj-10288	498	6	s.	s.	PROPN
cusj-10288	498	7	j.	j.	PROPN
cusj-10288	498	8	,	,	PUNCT
cusj-10288	498	9	ghosh	ghosh	PROPN
cusj-10288	498	10	,	,	PUNCT
cusj-10288	498	11	r.	r.	PROPN
cusj-10288	498	12	,	,	PUNCT
cusj-10288	498	13	&	&	CCONJ
cusj-10288	498	14	leavitt	leavitt	PROPN
cusj-10288	498	15	,	,	PUNCT
cusj-10288	498	16	b.	b.	PROPN
cusj-10288	498	17	r.	r.	PROPN
cusj-10288	498	18	(	(	PUNCT
cusj-10288	498	19	2019	2019	NUM
cusj-10288	498	20	)	)	PUNCT
cusj-10288	498	21	.	.	PUNCT
cusj-10288	499	1	huntingtin	huntingtin	NOUN
cusj-10288	499	2	lowering	lower	VERB
cusj-10288	499	3	strategies	strategy	NOUN
cusj-10288	499	4	for	for	ADP
cusj-10288	499	5	disease	disease	NOUN
cusj-10288	499	6	modification	modification	NOUN
cusj-10288	499	7	in	in	ADP
cusj-10288	499	8	huntington	huntington	PROPN
cusj-10288	499	9	's	's	PART
cusj-10288	499	10	disease	disease	NOUN
cusj-10288	499	11	.	.	PUNCT
cusj-10288	500	1	neuron	neuron	PROPN
cusj-10288	500	2	,	,	PUNCT
cusj-10288	500	3	102(4	102(4	NUM
cusj-10288	500	4	)	)	PUNCT
cusj-10288	500	5	,	,	PUNCT
cusj-10288	500	6	899	899	NUM
cusj-10288	500	7	.	.	PUNCT
cusj-10288	501	1	https://doi.org/10.1016/j.neuron.2019.05.001	https://doi.org/10.1016/j.neuron.2019.05.001	NOUN
cusj-10288	501	2	[	[	X
cusj-10288	501	3	71	71	NUM
cusj-10288	501	4	]	]	X
cusj-10288	501	5	lane	lane	NOUN
cusj-10288	501	6	,	,	PUNCT
cusj-10288	501	7	r.	r.	PROPN
cusj-10288	501	8	m.	m.	PROPN
cusj-10288	501	9	,	,	PUNCT
cusj-10288	501	10	smith	smith	PROPN
cusj-10288	501	11	,	,	PUNCT
cusj-10288	501	12	a.	a.	PROPN
cusj-10288	501	13	,	,	PUNCT
cusj-10288	501	14	baumann	baumann	PROPN
cusj-10288	501	15	,	,	PUNCT
cusj-10288	501	16	t.	t.	PROPN
cusj-10288	501	17	,	,	PUNCT
cusj-10288	501	18	gleichmann	gleichmann	PROPN
cusj-10288	501	19	,	,	PUNCT
cusj-10288	501	20	m.	m.	NOUN
cusj-10288	501	21	,	,	PUNCT
cusj-10288	501	22	norris	norris	PROPN
cusj-10288	501	23	,	,	PUNCT
cusj-10288	501	24	d.	d.	PROPN
cusj-10288	501	25	,	,	PUNCT
cusj-10288	501	26	bennett	bennett	PROPN
cusj-10288	501	27	,	,	PUNCT
cusj-10288	501	28	c.	c.	PROPN
cusj-10288	501	29	f.	f.	PROPN
cusj-10288	501	30	,	,	PUNCT
cusj-10288	501	31	&	&	CCONJ
cusj-10288	501	32	kordasiewicz	kordasiewicz	PROPN
cusj-10288	501	33	,	,	PUNCT
cusj-10288	501	34	h.	h.	PROPN
cusj-10288	501	35	(	(	PUNCT
cusj-10288	501	36	2018	2018	NUM
cusj-10288	501	37	)	)	PUNCT
cusj-10288	501	38	.	.	PUNCT
cusj-10288	502	1	translating	translate	VERB
cusj-10288	502	2	antisense	antisense	NOUN
cusj-10288	502	3	technology	technology	NOUN
cusj-10288	502	4	into	into	ADP
cusj-10288	502	5	a	a	DET
cusj-10288	502	6	treatment	treatment	NOUN
cusj-10288	502	7	for	for	ADP
cusj-10288	502	8	huntington	huntington	PROPN
cusj-10288	502	9	's	's	PART
cusj-10288	502	10	disease	disease	NOUN
cusj-10288	502	11	.	.	PUNCT
cusj-10288	503	1	methods	method	NOUN
cusj-10288	503	2	in	in	ADP
cusj-10288	503	3	molecular	molecular	ADJ
cusj-10288	503	4	biology	biology	NOUN
cusj-10288	503	5	(	(	PUNCT
cusj-10288	503	6	clifton	clifton	PROPN
cusj-10288	503	7	,	,	PUNCT
cusj-10288	503	8	n.j	n.j	PROPN
cusj-10288	503	9	.	.	PROPN
cusj-10288	503	10	)	)	PUNCT
cusj-10288	503	11	,	,	PUNCT
cusj-10288	503	12	1780	1780	NUM
cusj-10288	503	13	,	,	PUNCT
cusj-10288	503	14	497–523	497–523	NUM
cusj-10288	503	15	.	.	PUNCT
cusj-10288	504	1	https://doi.org/10.1007/978-1-4939-78250_23	https://doi.org/10.1007/978-1-4939-78250_23	PRON
cusj-10288	504	2	[	[	X
cusj-10288	504	3	72	72	NUM
cusj-10288	504	4	]	]	PUNCT
cusj-10288	504	5	tabrizi	tabrizi	NOUN
cusj-10288	504	6	,	,	PUNCT
cusj-10288	504	7	s.	s.	PROPN
cusj-10288	504	8	j.	j.	PROPN
cusj-10288	504	9	,	,	PUNCT
cusj-10288	504	10	leavitt	leavitt	PROPN
cusj-10288	504	11	,	,	PUNCT
cusj-10288	504	12	b.	b.	PROPN
cusj-10288	504	13	r.	r.	PROPN
cusj-10288	504	14	,	,	PUNCT
cusj-10288	504	15	landwehrmeyer	landwehrmeyer	PROPN
cusj-10288	504	16	,	,	PUNCT
cusj-10288	504	17	g.	g.	PROPN
cusj-10288	504	18	b.	b.	PROPN
cusj-10288	504	19	,	,	PUNCT
cusj-10288	504	20	wild	wild	PROPN
cusj-10288	504	21	,	,	PUNCT
cusj-10288	504	22	e.	e.	PROPN
cusj-10288	504	23	j.	j.	PROPN
cusj-10288	504	24	,	,	PUNCT
cusj-10288	504	25	saft	saft	PROPN
cusj-10288	504	26	,	,	PUNCT
cusj-10288	504	27	c.	c.	PROPN
cusj-10288	504	28	,	,	PUNCT
cusj-10288	504	29	barker	barker	PROPN
cusj-10288	504	30	,	,	PUNCT
cusj-10288	504	31	r.	r.	PROPN
cusj-10288	504	32	a.	a.	PROPN
cusj-10288	504	33	,	,	PUNCT
cusj-10288	504	34	blair	blair	PROPN
cusj-10288	504	35	,	,	PUNCT
cusj-10288	504	36	n.	n.	PROPN
cusj-10288	504	37	f.	f.	PROPN
cusj-10288	504	38	,	,	PUNCT
cusj-10288	504	39	craufurd	craufurd	PROPN
cusj-10288	504	40	,	,	PUNCT
cusj-10288	504	41	d.	d.	PROPN
cusj-10288	504	42	,	,	PUNCT
cusj-10288	504	43	priller	priller	NOUN
cusj-10288	504	44	,	,	PUNCT
cusj-10288	504	45	j.	j.	PROPN
cusj-10288	504	46	,	,	PUNCT
cusj-10288	504	47	rickards	rickard	NOUN
cusj-10288	504	48	,	,	PUNCT
cusj-10288	504	49	h.	h.	PROPN
cusj-10288	504	50	,	,	PUNCT
cusj-10288	504	51	rosser	rosser	PROPN
cusj-10288	504	52	,	,	PUNCT
cusj-10288	504	53	a.	a.	PROPN
cusj-10288	504	54	,	,	PUNCT
cusj-10288	504	55	kordasiewicz	kordasiewicz	PROPN
cusj-10288	504	56	,	,	PUNCT
cusj-10288	504	57	h.	h.	PROPN
cusj-10288	504	58	b.	b.	PROPN
cusj-10288	504	59	,	,	PUNCT
cusj-10288	504	60	czech	czech	PROPN
cusj-10288	504	61	,	,	PUNCT
cusj-10288	504	62	c.	c.	PROPN
cusj-10288	504	63	,	,	PUNCT
cusj-10288	504	64	swayze	swayze	PROPN
cusj-10288	504	65	,	,	PUNCT
cusj-10288	504	66	e.	e.	PROPN
cusj-10288	504	67	e.	e.	PROPN
cusj-10288	504	68	,	,	PUNCT
cusj-10288	504	69	norris	norris	PROPN
cusj-10288	504	70	,	,	PUNCT
cusj-10288	504	71	d.	d.	PROPN
cusj-10288	504	72	a.	a.	PROPN
cusj-10288	504	73	,	,	PUNCT
cusj-10288	504	74	baumann	baumann	PROPN
cusj-10288	504	75	,	,	PUNCT
cusj-10288	504	76	t.	t.	PROPN
cusj-10288	504	77	,	,	PUNCT
cusj-10288	504	78	gerlach	gerlach	PROPN
cusj-10288	504	79	,	,	PUNCT
cusj-10288	504	80	i.	i.	PROPN
cusj-10288	504	81	,	,	PUNCT
cusj-10288	504	82	schobel	schobel	PROPN
cusj-10288	504	83	,	,	PUNCT
cusj-10288	504	84	s.	s.	PROPN
cusj-10288	504	85	a.	a.	PROPN
cusj-10288	504	86	,	,	PUNCT
cusj-10288	504	87	paz	paz	PROPN
cusj-10288	504	88	,	,	PUNCT
cusj-10288	504	89	e.	e.	PROPN
cusj-10288	504	90	,	,	PUNCT
cusj-10288	504	91	smith	smith	PROPN
cusj-10288	504	92	,	,	PUNCT
cusj-10288	504	93	a.	a.	NOUN
cusj-10288	504	94	v.	v.	PROPN
cusj-10288	504	95	,	,	PUNCT
cusj-10288	504	96	…	…	PUNCT
cusj-10288	504	97	phase	phase	NOUN
cusj-10288	504	98	1–2a	1–2a	NUM
cusj-10288	504	99	ionishttrx	ionishttrx	ADJ
cusj-10288	504	100	study	study	NOUN
cusj-10288	504	101	site	site	NOUN
cusj-10288	504	102	teams	team	NOUN
cusj-10288	504	103	(	(	PUNCT
cusj-10288	504	104	2019	2019	NUM
cusj-10288	504	105	)	)	PUNCT
cusj-10288	504	106	.	.	PUNCT
cusj-10288	505	1	targeting	target	VERB
cusj-10288	505	2	huntingtin	huntingtin	ADJ
cusj-10288	505	3	expression	expression	NOUN
cusj-10288	505	4	in	in	ADP
cusj-10288	505	5	patients	patient	NOUN
cusj-10288	505	6	with	with	ADP
cusj-10288	505	7	huntington	huntington	PROPN
cusj-10288	505	8	's	's	PART
cusj-10288	505	9	disease	disease	NOUN
cusj-10288	505	10	.	.	PUNCT
cusj-10288	506	1	the	the	DET
cusj-10288	506	2	new	new	PROPN
cusj-10288	506	3	england	england	PROPN
cusj-10288	506	4	journal	journal	PROPN
cusj-10288	506	5	of	of	ADP
cusj-10288	506	6	medicine	medicine	NOUN
cusj-10288	506	7	,	,	PUNCT
cusj-10288	506	8	380(24	380(24	NUM
cusj-10288	506	9	)	)	PUNCT
cusj-10288	506	10	,	,	PUNCT
cusj-10288	506	11	2307–2316	2307–2316	NUM
cusj-10288	506	12	.	.	PUNCT
cusj-10288	506	13	https://doi.org/10.1056/nejmoa1900907	https://doi.org/10.1056/nejmoa1900907	PROPN
cusj-10288	507	1	[	[	X
cusj-10288	507	2	73	73	NUM
cusj-10288	507	3	]	]	X
cusj-10288	507	4	keiser	keiser	PROPN
cusj-10288	507	5	,	,	PUNCT
cusj-10288	507	6	m.	m.	NOUN
cusj-10288	507	7	s.	s.	PROPN
cusj-10288	507	8	,	,	PUNCT
cusj-10288	507	9	kordasiewicz	kordasiewicz	PROPN
cusj-10288	507	10	,	,	PUNCT
cusj-10288	507	11	h.	h.	PROPN
cusj-10288	507	12	b.	b.	PROPN
cusj-10288	507	13	,	,	PUNCT
cusj-10288	507	14	&	&	CCONJ
cusj-10288	507	15	mcbride	mcbride	PROPN
cusj-10288	507	16	,	,	PUNCT
cusj-10288	507	17	j.	j.	PROPN
cusj-10288	507	18	l.	l.	PROPN
cusj-10288	507	19	(	(	PUNCT
cusj-10288	507	20	2016	2016	NUM
cusj-10288	507	21	)	)	PUNCT
cusj-10288	507	22	.	.	PUNCT
cusj-10288	508	1	gene	gene	NOUN
cusj-10288	508	2	suppression	suppression	NOUN
cusj-10288	508	3	strategies	strategy	NOUN
cusj-10288	508	4	for	for	ADP
cusj-10288	508	5	dominantly	dominantly	ADV
cusj-10288	508	6	inherited	inherit	VERB
cusj-10288	508	7	neurodegenerative	neurodegenerative	ADJ
cusj-10288	508	8	diseases	disease	NOUN
cusj-10288	508	9	:	:	PUNCT
cusj-10288	508	10	lessons	lesson	NOUN
cusj-10288	508	11	from	from	ADP
cusj-10288	508	12	huntington	huntington	PROPN
cusj-10288	508	13	's	's	PART
cusj-10288	508	14	disease	disease	NOUN
cusj-10288	508	15	and	and	CCONJ
cusj-10288	508	16	spinocerebellar	spinocerebellar	ADJ
cusj-10288	508	17	ataxia	ataxia	NOUN
cusj-10288	508	18	.	.	PUNCT
cusj-10288	509	1	human	human	ADJ
cusj-10288	509	2	molecular	molecular	ADJ
cusj-10288	509	3	genetics	genetic	NOUN
cusj-10288	509	4	,	,	PUNCT
cusj-10288	509	5	25(r1	25(r1	NUM
cusj-10288	509	6	)	)	PUNCT
cusj-10288	509	7	,	,	PUNCT
cusj-10288	509	8	r53	r53	NOUN
cusj-10288	509	9	–	–	PUNCT
cusj-10288	509	10	r64	r64	NOUN
cusj-10288	509	11	.	.	PUNCT
cusj-10288	510	1	https://doi.org/10.1093/hmg/ddv442	https://doi.org/10.1093/hmg/ddv442	PROPN
cusj-10288	510	2	[	[	X
cusj-10288	510	3	74	74	NUM
cusj-10288	510	4	]	]	PUNCT
cusj-10288	510	5	difiglia	difiglia	PROPN
cusj-10288	510	6	,	,	PUNCT
cusj-10288	510	7	m.	m.	NOUN
cusj-10288	510	8	,	,	PUNCT
cusj-10288	510	9	sena	sena	PROPN
cusj-10288	510	10	-	-	PUNCT
cusj-10288	510	11	esteves	esteves	PROPN
cusj-10288	510	12	,	,	PUNCT
cusj-10288	510	13	m.	m.	NOUN
cusj-10288	510	14	,	,	PUNCT
cusj-10288	510	15	chase	chase	PROPN
cusj-10288	510	16	,	,	PUNCT
cusj-10288	510	17	k.	k.	PROPN
cusj-10288	510	18	,	,	PUNCT
cusj-10288	510	19	sapp	sapp	PROPN
cusj-10288	510	20	,	,	PUNCT
cusj-10288	510	21	e.	e.	PROPN
cusj-10288	510	22	,	,	PUNCT
cusj-10288	510	23	pfister	pfister	PROPN
cusj-10288	510	24	,	,	PUNCT
cusj-10288	510	25	e.	e.	PROPN
cusj-10288	510	26	,	,	PUNCT
cusj-10288	510	27	sass	sass	NOUN
cusj-10288	510	28	,	,	PUNCT
cusj-10288	510	29	m.	m.	NOUN
cusj-10288	510	30	,	,	PUNCT
cusj-10288	510	31	yoder	yoder	PROPN
cusj-10288	510	32	,	,	PUNCT
cusj-10288	510	33	j.	j.	PROPN
cusj-10288	510	34	,	,	PUNCT
cusj-10288	510	35	reeves	reeves	PROPN
cusj-10288	510	36	,	,	PUNCT
cusj-10288	510	37	p.	p.	PROPN
cusj-10288	510	38	,	,	PUNCT
cusj-10288	510	39	pandey	pandey	PROPN
cusj-10288	510	40	,	,	PUNCT
cusj-10288	510	41	r.	r.	PROPN
cusj-10288	510	42	k.	k.	PROPN
cusj-10288	510	43	,	,	PUNCT
cusj-10288	510	44	rajeev	rajeev	PROPN
cusj-10288	510	45	,	,	PUNCT
cusj-10288	510	46	k.	k.	PROPN
cusj-10288	510	47	g.	g.	PROPN
cusj-10288	510	48	,	,	PUNCT
cusj-10288	510	49	columbia	columbia	PROPN
cusj-10288	510	50	undergraduate	undergraduate	PROPN
cusj-10288	510	51	science	science	PROPN
cusj-10288	510	52	journal	journal	PROPN
cusj-10288	510	53	vol	vol	NOUN
cusj-10288	510	54	.	.	PROPN
cusj-10288	510	55	17	17	NUM
cusj-10288	510	56	,	,	PUNCT
cusj-10288	510	57	2023	2023	NUM
cusj-10288	510	58	datta	datta	NOUN
cusj-10288	510	59	33	33	NUM
cusj-10288	510	60	manoharan	manoharan	NOUN
cusj-10288	510	61	,	,	PUNCT
cusj-10288	510	62	m.	m.	NOUN
cusj-10288	510	63	,	,	PUNCT
cusj-10288	510	64	sah	sah	PROPN
cusj-10288	510	65	,	,	PUNCT
cusj-10288	510	66	d.	d.	PROPN
cusj-10288	510	67	w.	w.	PROPN
cusj-10288	510	68	,	,	PUNCT
cusj-10288	510	69	zamore	zamore	PROPN
cusj-10288	510	70	,	,	PUNCT
cusj-10288	510	71	p.	p.	PROPN
cusj-10288	510	72	d.	d.	PROPN
cusj-10288	510	73	,	,	PUNCT
cusj-10288	510	74	&	&	CCONJ
cusj-10288	510	75	aronin	aronin	PROPN
cusj-10288	510	76	,	,	PUNCT
cusj-10288	510	77	n.	n.	PROPN
cusj-10288	510	78	(	(	PUNCT
cusj-10288	510	79	2007	2007	NUM
cusj-10288	510	80	)	)	PUNCT
cusj-10288	510	81	.	.	PUNCT
cusj-10288	511	1	therapeutic	therapeutic	ADJ
cusj-10288	511	2	silencing	silencing	NOUN
cusj-10288	511	3	of	of	ADP
cusj-10288	511	4	mutant	mutant	ADJ
cusj-10288	511	5	huntingtin	huntingtin	NOUN
cusj-10288	511	6	with	with	ADP
cusj-10288	511	7	sirna	sirna	PROPN
cusj-10288	511	8	attenuates	attenuate	VERB
cusj-10288	511	9	striatal	striatal	ADJ
cusj-10288	511	10	and	and	CCONJ
cusj-10288	511	11	cortical	cortical	ADJ
cusj-10288	511	12	neuropathology	neuropathology	NOUN
cusj-10288	511	13	and	and	CCONJ
cusj-10288	511	14	behavioral	behavioral	ADJ
cusj-10288	511	15	deficits	deficit	NOUN
cusj-10288	511	16	.	.	PUNCT
cusj-10288	512	1	proceedings	proceeding	NOUN
cusj-10288	512	2	of	of	ADP
cusj-10288	512	3	the	the	DET
cusj-10288	512	4	national	national	PROPN
cusj-10288	512	5	academy	academy	PROPN
cusj-10288	512	6	of	of	ADP
cusj-10288	512	7	sciences	sciences	PROPN
cusj-10288	512	8	of	of	ADP
cusj-10288	512	9	the	the	DET
cusj-10288	512	10	united	united	PROPN
cusj-10288	512	11	states	states	PROPN
cusj-10288	512	12	of	of	ADP
cusj-10288	512	13	america	america	PROPN
cusj-10288	512	14	,	,	PUNCT
cusj-10288	512	15	104(43	104(43	NUM
cusj-10288	512	16	)	)	PUNCT
cusj-10288	512	17	,	,	PUNCT
cusj-10288	512	18	17204–17209	17204–17209	NUM
cusj-10288	512	19	.	.	PUNCT
cusj-10288	513	1	https://doi.org/10.1073/pnas.0708285104	https://doi.org/10.1073/pnas.0708285104	PUNCT
cusj-10288	514	1	[	[	X
cusj-10288	514	2	75	75	NUM
cusj-10288	514	3	]	]	SYM
cusj-10288	514	4	yu	yu	PROPN
cusj-10288	514	5	,	,	PUNCT
cusj-10288	514	6	d.	d.	PROPN
cusj-10288	514	7	,	,	PUNCT
cusj-10288	514	8	pendergraff	pendergraff	NOUN
cusj-10288	514	9	,	,	PUNCT
cusj-10288	514	10	h.	h.	PROPN
cusj-10288	514	11	,	,	PUNCT
cusj-10288	514	12	liu	liu	PROPN
cusj-10288	514	13	,	,	PUNCT
cusj-10288	514	14	j.	j.	PROPN
cusj-10288	514	15	,	,	PUNCT
cusj-10288	514	16	kordasiewicz	kordasiewicz	PROPN
cusj-10288	514	17	,	,	PUNCT
cusj-10288	514	18	h.	h.	PROPN
cusj-10288	514	19	b.	b.	PROPN
cusj-10288	514	20	,	,	PUNCT
cusj-10288	514	21	cleveland	cleveland	PROPN
cusj-10288	514	22	,	,	PUNCT
cusj-10288	514	23	d.	d.	PROPN
cusj-10288	514	24	w.	w.	PROPN
cusj-10288	514	25	,	,	PUNCT
cusj-10288	514	26	swayze	swayze	PROPN
cusj-10288	514	27	,	,	PUNCT
cusj-10288	514	28	e.	e.	PROPN
cusj-10288	514	29	e.	e.	PROPN
cusj-10288	514	30	,	,	PUNCT
cusj-10288	514	31	lima	lima	PROPN
cusj-10288	514	32	,	,	PUNCT
cusj-10288	514	33	w.	w.	PROPN
cusj-10288	514	34	f.	f.	PROPN
cusj-10288	514	35	,	,	PUNCT
cusj-10288	514	36	crooke	crooke	NOUN
cusj-10288	514	37	,	,	PUNCT
cusj-10288	514	38	s.	s.	PROPN
cusj-10288	514	39	t.	t.	PROPN
cusj-10288	514	40	,	,	PUNCT
cusj-10288	514	41	prakash	prakash	PROPN
cusj-10288	514	42	,	,	PUNCT
cusj-10288	514	43	t.	t.	PROPN
cusj-10288	514	44	p.	p.	PROPN
cusj-10288	514	45	,	,	PUNCT
cusj-10288	514	46	&	&	CCONJ
cusj-10288	514	47	corey	corey	PROPN
cusj-10288	514	48	,	,	PUNCT
cusj-10288	514	49	d.	d.	PROPN
cusj-10288	514	50	r.	r.	PROPN
cusj-10288	514	51	(	(	PUNCT
cusj-10288	514	52	2012	2012	NUM
cusj-10288	514	53	)	)	PUNCT
cusj-10288	514	54	.	.	PUNCT
cusj-10288	515	1	single	single	ADJ
cusj-10288	515	2	-	-	PUNCT
cusj-10288	515	3	stranded	strand	VERB
cusj-10288	515	4	rnas	rna	NOUN
cusj-10288	515	5	use	use	VERB
cusj-10288	515	6	rnai	rnai	NOUN
cusj-10288	515	7	to	to	PART
cusj-10288	515	8	potently	potently	ADV
cusj-10288	515	9	and	and	CCONJ
cusj-10288	515	10	alleleselectively	alleleselectively	ADV
cusj-10288	515	11	inhibit	inhibit	VERB
cusj-10288	515	12	mutant	mutant	ADJ
cusj-10288	515	13	huntingtin	huntingtin	NOUN
cusj-10288	515	14	expression	expression	NOUN
cusj-10288	515	15	.	.	PUNCT
cusj-10288	516	1	cell	cell	NOUN
cusj-10288	516	2	,	,	PUNCT
cusj-10288	516	3	150(5	150(5	NUM
cusj-10288	516	4	)	)	PUNCT
cusj-10288	516	5	,	,	PUNCT
cusj-10288	516	6	895–908	895–908	NUM
cusj-10288	516	7	.	.	PUNCT
cusj-10288	517	1	https://doi.org/10.1016/j.cell.2012.08.002	https://doi.org/10.1016/j.cell.2012.08.002	PROPN
cusj-10288	517	2	[	[	X
cusj-10288	517	3	76	76	NUM
cusj-10288	517	4	]	]	X
cusj-10288	517	5	dufour	dufour	PROPN
cusj-10288	517	6	,	,	PUNCT
cusj-10288	517	7	b.	b.	PROPN
cusj-10288	517	8	d.	d.	PROPN
cusj-10288	517	9	,	,	PUNCT
cusj-10288	517	10	smith	smith	PROPN
cusj-10288	517	11	,	,	PUNCT
cusj-10288	517	12	c.	c.	PROPN
cusj-10288	517	13	a.	a.	PROPN
cusj-10288	517	14	,	,	PUNCT
cusj-10288	517	15	clark	clark	PROPN
cusj-10288	517	16	,	,	PUNCT
cusj-10288	517	17	r.	r.	PROPN
cusj-10288	517	18	l.	l.	PROPN
cusj-10288	517	19	,	,	PUNCT
cusj-10288	517	20	walker	walker	PROPN
cusj-10288	517	21	,	,	PUNCT
cusj-10288	517	22	t.	t.	PROPN
cusj-10288	517	23	r.	r.	PROPN
cusj-10288	517	24	,	,	PUNCT
cusj-10288	517	25	&	&	CCONJ
cusj-10288	517	26	mcbride	mcbride	PROPN
cusj-10288	517	27	,	,	PUNCT
cusj-10288	517	28	j.	j.	PROPN
cusj-10288	517	29	l.	l.	PROPN
cusj-10288	517	30	(	(	PUNCT
cusj-10288	517	31	2014	2014	NUM
cusj-10288	517	32	)	)	PUNCT
cusj-10288	517	33	.	.	PUNCT
cusj-10288	518	1	intrajugular	intrajugular	ADJ
cusj-10288	518	2	vein	vein	ADJ
cusj-10288	518	3	delivery	delivery	NOUN
cusj-10288	518	4	of	of	ADP
cusj-10288	518	5	aav9	aav9	PROPN
cusj-10288	518	6	-	-	PUNCT
cusj-10288	518	7	rnai	rnai	PROPN
cusj-10288	518	8	prevents	prevent	VERB
cusj-10288	518	9	neuropathological	neuropathological	ADJ
cusj-10288	518	10	changes	change	NOUN
cusj-10288	518	11	and	and	CCONJ
cusj-10288	518	12	weight	weight	NOUN
cusj-10288	518	13	loss	loss	NOUN
cusj-10288	518	14	in	in	ADP
cusj-10288	518	15	huntington	huntington	PROPN
cusj-10288	518	16	's	's	PART
cusj-10288	518	17	disease	disease	NOUN
cusj-10288	518	18	mice	mouse	NOUN
cusj-10288	518	19	.	.	PUNCT
cusj-10288	519	1	molecular	molecular	ADJ
cusj-10288	519	2	therapy	therapy	NOUN
cusj-10288	519	3	:	:	PUNCT
cusj-10288	519	4	the	the	DET
cusj-10288	519	5	journal	journal	NOUN
cusj-10288	519	6	of	of	ADP
cusj-10288	519	7	the	the	DET
cusj-10288	519	8	american	american	ADJ
cusj-10288	519	9	society	society	NOUN
cusj-10288	519	10	of	of	ADP
cusj-10288	519	11	gene	gene	NOUN
cusj-10288	519	12	therapy	therapy	NOUN
cusj-10288	519	13	,	,	PUNCT
cusj-10288	519	14	22(4	22(4	NUM
cusj-10288	519	15	)	)	PUNCT
cusj-10288	519	16	,	,	PUNCT
cusj-10288	519	17	797–810	797–810	NUM
cusj-10288	519	18	.	.	PUNCT
cusj-10288	520	1	https://doi.org/10.1038/mt.2013.289	https://doi.org/10.1038/mt.2013.289	ADJ
cusj-10288	521	1	[	[	X
cusj-10288	521	2	77	77	NUM
cusj-10288	521	3	]	]	X
cusj-10288	521	4	ho	ho	PROPN
cusj-10288	521	5	,	,	PUNCT
cusj-10288	521	6	l.	l.	PROPN
cusj-10288	521	7	w.	w.	PROPN
cusj-10288	521	8	,	,	PUNCT
cusj-10288	521	9	brown	brown	PROPN
cusj-10288	521	10	,	,	PUNCT
cusj-10288	521	11	r.	r.	PROPN
cusj-10288	521	12	,	,	PUNCT
cusj-10288	521	13	maxwell	maxwell	PROPN
cusj-10288	521	14	,	,	PUNCT
cusj-10288	521	15	m.	m.	NOUN
cusj-10288	521	16	,	,	PUNCT
cusj-10288	521	17	wyttenbach	wyttenbach	ADV
cusj-10288	521	18	,	,	PUNCT
cusj-10288	521	19	a.	a.	NOUN
cusj-10288	521	20	,	,	PUNCT
cusj-10288	521	21	&	&	CCONJ
cusj-10288	521	22	rubinsztein	rubinsztein	PROPN
cusj-10288	521	23	,	,	PUNCT
cusj-10288	521	24	d.	d.	PROPN
cusj-10288	521	25	c.	c.	PROPN
cusj-10288	521	26	(	(	PUNCT
cusj-10288	521	27	2001	2001	NUM
cusj-10288	521	28	)	)	PUNCT
cusj-10288	521	29	.	.	PUNCT
cusj-10288	522	1	wild	wild	ADJ
cusj-10288	522	2	type	type	NOUN
cusj-10288	522	3	huntingtin	huntingtin	NOUN
cusj-10288	522	4	reduces	reduce	VERB
cusj-10288	522	5	the	the	DET
cusj-10288	522	6	cellular	cellular	ADJ
cusj-10288	522	7	toxicity	toxicity	NOUN
cusj-10288	522	8	of	of	ADP
cusj-10288	522	9	mutant	mutant	ADJ
cusj-10288	522	10	huntingtin	huntingtin	NOUN
cusj-10288	522	11	in	in	ADP
cusj-10288	522	12	mammalian	mammalian	ADJ
cusj-10288	522	13	cell	cell	NOUN
cusj-10288	522	14	models	model	NOUN
cusj-10288	522	15	of	of	ADP
cusj-10288	522	16	huntington	huntington	PROPN
cusj-10288	522	17	's	's	PART
cusj-10288	522	18	disease	disease	NOUN
cusj-10288	522	19	.	.	PUNCT
cusj-10288	523	1	journal	journal	PROPN
cusj-10288	523	2	of	of	ADP
cusj-10288	523	3	medical	medical	ADJ
cusj-10288	523	4	genetics	genetic	NOUN
cusj-10288	523	5	,	,	PUNCT
cusj-10288	523	6	38(7	38(7	NUM
cusj-10288	523	7	)	)	PUNCT
cusj-10288	523	8	,	,	PUNCT
cusj-10288	523	9	450–452	450–452	NUM
cusj-10288	523	10	.	.	PUNCT
cusj-10288	524	1	https://doi.org/10.1136/jmg.38.7.450	https://doi.org/10.1136/jmg.38.7.450	X
cusj-10288	524	2	[	[	X
cusj-10288	524	3	78	78	NUM
cusj-10288	524	4	]	]	X
cusj-10288	524	5	huntington	huntington	PROPN
cusj-10288	524	6	study	study	PROPN
cusj-10288	524	7	group	group	NOUN
cusj-10288	524	8	(	(	PUNCT
cusj-10288	524	9	2006	2006	NUM
cusj-10288	524	10	)	)	PUNCT
cusj-10288	524	11	.	.	PUNCT
cusj-10288	525	1	tetrabenazine	tetrabenazine	PROPN
cusj-10288	525	2	as	as	ADP
cusj-10288	525	3	antichorea	antichorea	PROPN
cusj-10288	525	4	therapy	therapy	PROPN
cusj-10288	525	5	in	in	ADP
cusj-10288	525	6	huntington	huntington	PROPN
cusj-10288	525	7	disease	disease	PROPN
cusj-10288	525	8	:	:	PUNCT
cusj-10288	525	9	a	a	DET
cusj-10288	525	10	randomized	randomized	ADJ
cusj-10288	525	11	controlled	control	VERB
cusj-10288	525	12	trial	trial	NOUN
cusj-10288	525	13	.	.	PUNCT
cusj-10288	526	1	neurology	neurology	NOUN
cusj-10288	526	2	,	,	PUNCT
cusj-10288	526	3	66(3	66(3	NOUN
cusj-10288	526	4	)	)	PUNCT
cusj-10288	526	5	,	,	PUNCT
cusj-10288	526	6	366–372	366–372	NUM
cusj-10288	526	7	.	.	PUNCT
cusj-10288	526	8	https://doi.org/10.1212/01.wnl.0000198586.8	https://doi.org/10.1212/01.wnl.0000198586.8	NOUN
cusj-10288	527	1	5250.13	5250.13	NUM
cusj-10288	527	2	[	[	SYM
cusj-10288	527	3	79	79	NUM
cusj-10288	527	4	]	]	X
cusj-10288	527	5	arora	arora	PROPN
cusj-10288	527	6	,	,	PUNCT
cusj-10288	527	7	a.	a.	PROPN
cusj-10288	527	8	,	,	PUNCT
cusj-10288	527	9	kumar	kumar	PROPN
cusj-10288	527	10	,	,	PUNCT
cusj-10288	527	11	s.	s.	PROPN
cusj-10288	527	12	,	,	PUNCT
cusj-10288	527	13	ali	ali	PROPN
cusj-10288	527	14	,	,	PUNCT
cusj-10288	527	15	j.	j.	PROPN
cusj-10288	527	16	,	,	PUNCT
cusj-10288	527	17	&	&	CCONJ
cusj-10288	527	18	baboota	baboota	PROPN
cusj-10288	527	19	,	,	PUNCT
cusj-10288	527	20	s.	s.	PROPN
cusj-10288	527	21	(	(	PUNCT
cusj-10288	527	22	2020	2020	NUM
cusj-10288	527	23	)	)	PUNCT
cusj-10288	527	24	.	.	PUNCT
cusj-10288	528	1	intranasal	intranasal	ADJ
cusj-10288	528	2	delivery	delivery	NOUN
cusj-10288	528	3	of	of	ADP
cusj-10288	528	4	tetrabenazine	tetrabenazine	ADJ
cusj-10288	528	5	nanoemulsion	nanoemulsion	NOUN
cusj-10288	528	6	via	via	ADP
cusj-10288	528	7	olfactory	olfactory	ADJ
cusj-10288	528	8	region	region	NOUN
cusj-10288	528	9	for	for	ADP
cusj-10288	528	10	better	well	ADJ
cusj-10288	528	11	treatment	treatment	NOUN
cusj-10288	528	12	of	of	ADP
cusj-10288	528	13	hyperkinetic	hyperkinetic	ADJ
cusj-10288	528	14	movement	movement	NOUN
cusj-10288	528	15	associated	associate	VERB
cusj-10288	528	16	with	with	ADP
cusj-10288	528	17	huntington	huntington	PROPN
cusj-10288	528	18	's	's	PART
cusj-10288	528	19	disease	disease	NOUN
cusj-10288	528	20	:	:	PUNCT
cusj-10288	528	21	pharmacokinetic	pharmacokinetic	ADJ
cusj-10288	528	22	and	and	CCONJ
cusj-10288	528	23	brain	brain	NOUN
cusj-10288	528	24	delivery	delivery	NOUN
cusj-10288	528	25	study	study	NOUN
cusj-10288	528	26	.	.	PUNCT
cusj-10288	529	1	chemistry	chemistry	NOUN
cusj-10288	529	2	and	and	CCONJ
cusj-10288	529	3	physics	physic	NOUN
cusj-10288	529	4	of	of	ADP
cusj-10288	529	5	lipids	lipid	NOUN
cusj-10288	529	6	,	,	PUNCT
cusj-10288	529	7	230	230	NUM
cusj-10288	529	8	,	,	PUNCT
cusj-10288	529	9	104917	104917	NUM
cusj-10288	529	10	.	.	PUNCT
cusj-10288	530	1	https://doi.org/10.1016/j.chemphyslip.2020.1	https://doi.org/10.1016/j.chemphyslip.2020.1	NUM
cusj-10288	530	2	04917	04917	NUM
cusj-10288	530	3	[	[	X
cusj-10288	530	4	80	80	NUM
cusj-10288	530	5	]	]	X
cusj-10288	530	6	devi	devi	PROPN
cusj-10288	530	7	,	,	PUNCT
cusj-10288	530	8	s.	s.	PROPN
cusj-10288	530	9	,	,	PUNCT
cusj-10288	530	10	kumar	kumar	PROPN
cusj-10288	530	11	,	,	PUNCT
cusj-10288	530	12	v.	v.	PROPN
cusj-10288	530	13	,	,	PUNCT
cusj-10288	530	14	singh	singh	PROPN
cusj-10288	530	15	,	,	PUNCT
cusj-10288	530	16	s.	s.	PROPN
cusj-10288	530	17	k.	k.	PROPN
cusj-10288	530	18	,	,	PUNCT
cusj-10288	530	19	dubey	dubey	PROPN
cusj-10288	530	20	,	,	PUNCT
cusj-10288	530	21	a.	a.	PROPN
cusj-10288	530	22	k.	k.	PROPN
cusj-10288	530	23	,	,	PUNCT
cusj-10288	530	24	&	&	CCONJ
cusj-10288	530	25	kim	kim	PROPN
cusj-10288	530	26	,	,	PUNCT
cusj-10288	530	27	j.	j.	PROPN
cusj-10288	530	28	j.	j.	PROPN
cusj-10288	530	29	(	(	PUNCT
cusj-10288	530	30	2021	2021	NUM
cusj-10288	530	31	)	)	PUNCT
cusj-10288	530	32	.	.	PUNCT
cusj-10288	531	1	flavonoids	flavonoid	NOUN
cusj-10288	531	2	:	:	PUNCT
cusj-10288	531	3	potential	potential	ADJ
cusj-10288	531	4	candidates	candidate	NOUN
cusj-10288	531	5	for	for	ADP
cusj-10288	531	6	the	the	DET
cusj-10288	531	7	treatment	treatment	NOUN
cusj-10288	531	8	of	of	ADP
cusj-10288	531	9	neurodegenerative	neurodegenerative	ADJ
cusj-10288	531	10	disorders	disorder	NOUN
cusj-10288	531	11	.	.	PUNCT
cusj-10288	532	1	biomedicines	biomedicine	NOUN
cusj-10288	532	2	,	,	PUNCT
cusj-10288	532	3	9(2	9(2	NUM
cusj-10288	532	4	)	)	PUNCT
cusj-10288	532	5	,	,	PUNCT
cusj-10288	532	6	99	99	NUM
cusj-10288	532	7	.	.	PUNCT
cusj-10288	533	1	https://doi.org/10.3390/biomedicines9020099	https://doi.org/10.3390/biomedicines9020099	PROPN
cusj-10288	533	2	[	[	X
cusj-10288	533	3	81	81	NUM
cusj-10288	533	4	]	]	PUNCT
cusj-10288	533	5	catanesi	catanesi	NOUN
cusj-10288	533	6	,	,	PUNCT
cusj-10288	533	7	m.	m.	NOUN
cusj-10288	533	8	,	,	PUNCT
cusj-10288	533	9	caioni	caioni	PROPN
cusj-10288	533	10	,	,	PUNCT
cusj-10288	533	11	g.	g.	PROPN
cusj-10288	533	12	,	,	PUNCT
cusj-10288	533	13	castelli	castelli	PROPN
cusj-10288	533	14	,	,	PUNCT
cusj-10288	533	15	v.	v.	PROPN
cusj-10288	533	16	,	,	PUNCT
cusj-10288	533	17	benedetti	benedetti	PROPN
cusj-10288	533	18	,	,	PUNCT
cusj-10288	533	19	e.	e.	PROPN
cusj-10288	533	20	,	,	PUNCT
cusj-10288	533	21	d'angelo	d'angelo	PROPN
cusj-10288	533	22	,	,	PUNCT
cusj-10288	533	23	m.	m.	NOUN
cusj-10288	533	24	,	,	PUNCT
cusj-10288	533	25	&	&	CCONJ
cusj-10288	533	26	cimini	cimini	PROPN
cusj-10288	533	27	,	,	PUNCT
cusj-10288	533	28	a.	a.	NOUN
cusj-10288	533	29	(	(	PUNCT
cusj-10288	533	30	2021	2021	NUM
cusj-10288	533	31	)	)	PUNCT
cusj-10288	533	32	.	.	PUNCT
cusj-10288	534	1	benefits	benefit	NOUN
cusj-10288	534	2	under	under	ADP
cusj-10288	534	3	the	the	DET
cusj-10288	534	4	sea	sea	NOUN
cusj-10288	534	5	:	:	PUNCT
cusj-10288	534	6	the	the	DET
cusj-10288	534	7	role	role	NOUN
cusj-10288	534	8	of	of	ADP
cusj-10288	534	9	marine	marine	ADJ
cusj-10288	534	10	compounds	compound	NOUN
cusj-10288	534	11	in	in	ADP
cusj-10288	534	12	neurodegenerative	neurodegenerative	ADJ
cusj-10288	534	13	disorders	disorder	NOUN
cusj-10288	534	14	.	.	PUNCT
cusj-10288	535	1	marine	marine	ADJ
cusj-10288	535	2	drugs	drug	NOUN
cusj-10288	535	3	,	,	PUNCT
cusj-10288	535	4	19(1	19(1	NUM
cusj-10288	535	5	)	)	PUNCT
cusj-10288	535	6	,	,	PUNCT
cusj-10288	535	7	24	24	NUM
cusj-10288	535	8	.	.	PUNCT
cusj-10288	535	9	https://doi.org/10.3390/md19010024	https://doi.org/10.3390/md19010024	PROPN
cusj-10288	536	1	[	[	X
cusj-10288	536	2	82	82	NUM
cusj-10288	536	3	]	]	X
cusj-10288	536	4	jabłońska	jabłońska	ADJ
cusj-10288	536	5	,	,	PUNCT
cusj-10288	536	6	m.	m.	NOUN
cusj-10288	536	7	,	,	PUNCT
cusj-10288	536	8	grzelakowska	grzelakowska	NOUN
cusj-10288	536	9	,	,	PUNCT
cusj-10288	536	10	k.	k.	PROPN
cusj-10288	536	11	,	,	PUNCT
cusj-10288	536	12	wiśniewski	wiśniewski	PROPN
cusj-10288	536	13	,	,	PUNCT
cusj-10288	536	14	b.	b.	PROPN
cusj-10288	536	15	,	,	PUNCT
cusj-10288	536	16	mazur	mazur	PROPN
cusj-10288	536	17	,	,	PUNCT
cusj-10288	536	18	e.	e.	PROPN
cusj-10288	536	19	,	,	PUNCT
cusj-10288	536	20	leis	leis	NOUN
cusj-10288	536	21	,	,	PUNCT
cusj-10288	536	22	k.	k.	PROPN
cusj-10288	536	23	,	,	PUNCT
cusj-10288	536	24	&	&	CCONJ
cusj-10288	536	25	gałązka	gałązka	PROPN
cusj-10288	536	26	,	,	PUNCT
cusj-10288	536	27	p.	p.	NOUN
cusj-10288	536	28	(	(	PUNCT
cusj-10288	536	29	2020	2020	NUM
cusj-10288	536	30	)	)	PUNCT
cusj-10288	536	31	.	.	PUNCT
cusj-10288	537	1	pridopidine	pridopidine	NOUN
cusj-10288	537	2	in	in	ADP
cusj-10288	537	3	the	the	DET
cusj-10288	537	4	treatment	treatment	NOUN
cusj-10288	537	5	of	of	ADP
cusj-10288	537	6	huntington	huntington	PROPN
cusj-10288	537	7	's	's	PART
cusj-10288	537	8	disease	disease	NOUN
cusj-10288	537	9	.	.	PUNCT
cusj-10288	538	1	reviews	review	NOUN
cusj-10288	538	2	in	in	ADP
cusj-10288	538	3	the	the	DET
cusj-10288	538	4	neurosciences	neuroscience	NOUN
cusj-10288	538	5	,	,	PUNCT
cusj-10288	538	6	31(4	31(4	NUM
cusj-10288	538	7	)	)	PUNCT
cusj-10288	538	8	,	,	PUNCT
cusj-10288	538	9	441–451	441–451	NUM
cusj-10288	538	10	.	.	PUNCT
cusj-10288	539	1	https://doi.org/10.1515/revneuro-2019-0085	https://doi.org/10.1515/revneuro-2019-0085	PROPN
cusj-10288	539	2	[	[	X
cusj-10288	539	3	83	83	NUM
cusj-10288	539	4	]	]	X
cusj-10288	539	5	garcia	garcia	PROPN
cusj-10288	539	6	-	-	PUNCT
cusj-10288	539	7	miralles	miralle	NOUN
cusj-10288	539	8	,	,	PUNCT
cusj-10288	539	9	m.	m.	NOUN
cusj-10288	539	10	,	,	PUNCT
cusj-10288	539	11	geva	geva	PROPN
cusj-10288	539	12	,	,	PUNCT
cusj-10288	539	13	m.	m.	NOUN
cusj-10288	539	14	,	,	PUNCT
cusj-10288	539	15	tan	tan	PROPN
cusj-10288	539	16	,	,	PUNCT
cusj-10288	539	17	j.	j.	PROPN
cusj-10288	539	18	y.	y.	PROPN
cusj-10288	539	19	,	,	PUNCT
cusj-10288	539	20	yusof	yusof	NOUN
cusj-10288	539	21	,	,	PUNCT
cusj-10288	539	22	n.	n.	PROPN
cusj-10288	539	23	a.	a.	PROPN
cusj-10288	539	24	b.	b.	PROPN
cusj-10288	539	25	m.	m.	PROPN
cusj-10288	539	26	,	,	PUNCT
cusj-10288	539	27	cha	cha	PROPN
cusj-10288	539	28	,	,	PUNCT
cusj-10288	539	29	y.	y.	PROPN
cusj-10288	539	30	,	,	PUNCT
cusj-10288	539	31	kusko	kusko	PROPN
cusj-10288	539	32	,	,	PUNCT
cusj-10288	539	33	r.	r.	PROPN
cusj-10288	539	34	,	,	PUNCT
cusj-10288	539	35	tan	tan	PROPN
cusj-10288	539	36	,	,	PUNCT
cusj-10288	539	37	l.	l.	PROPN
cusj-10288	539	38	j.	j.	PROPN
cusj-10288	539	39	,	,	PUNCT
cusj-10288	539	40	xu	xu	PROPN
cusj-10288	539	41	,	,	PUNCT
cusj-10288	539	42	x.	x.	PROPN
cusj-10288	539	43	,	,	PUNCT
cusj-10288	539	44	grossman	grossman	PROPN
cusj-10288	539	45	,	,	PUNCT
cusj-10288	539	46	i.	i.	PROPN
cusj-10288	539	47	,	,	PUNCT
cusj-10288	539	48	orbach	orbach	PROPN
cusj-10288	539	49	,	,	PUNCT
cusj-10288	539	50	a.	a.	NOUN
cusj-10288	539	51	,	,	PUNCT
cusj-10288	539	52	hayden	hayden	PROPN
cusj-10288	539	53	,	,	PUNCT
cusj-10288	539	54	m.	m.	PROPN
cusj-10288	539	55	r.	r.	PROPN
cusj-10288	539	56	,	,	PUNCT
cusj-10288	539	57	&	&	CCONJ
cusj-10288	539	58	pouladi	pouladi	NOUN
cusj-10288	539	59	,	,	PUNCT
cusj-10288	539	60	m.	m.	NOUN
cusj-10288	539	61	a.	a.	NOUN
cusj-10288	539	62	(	(	PUNCT
cusj-10288	539	63	2017	2017	NUM
cusj-10288	539	64	)	)	PUNCT
cusj-10288	539	65	.	.	PUNCT
cusj-10288	540	1	early	early	ADJ
cusj-10288	540	2	pridopidine	pridopidine	ADJ
cusj-10288	540	3	treatment	treatment	NOUN
cusj-10288	540	4	improves	improve	VERB
cusj-10288	540	5	behavioral	behavioral	ADJ
cusj-10288	540	6	and	and	CCONJ
cusj-10288	540	7	transcriptional	transcriptional	ADJ
cusj-10288	540	8	deficits	deficit	NOUN
cusj-10288	540	9	in	in	ADP
cusj-10288	540	10	yac128	yac128	PROPN
cusj-10288	540	11	huntington	huntington	PROPN
cusj-10288	540	12	disease	disease	NOUN
cusj-10288	540	13	mice	mouse	NOUN
cusj-10288	540	14	.	.	PUNCT
cusj-10288	541	1	jci	jci	PROPN
cusj-10288	541	2	insight	insight	PROPN
cusj-10288	541	3	,	,	PUNCT
cusj-10288	541	4	2(23	2(23	NOUN
cusj-10288	541	5	)	)	PUNCT
cusj-10288	541	6	,	,	PUNCT
cusj-10288	541	7	e95665	e95665	NOUN
cusj-10288	541	8	.	.	PUNCT
cusj-10288	541	9	https://doi.org/10.1172/jci.insight.95665	https://doi.org/10.1172/jci.insight.95665	PROPN
cusj-10288	542	1	[	[	X
cusj-10288	542	2	84	84	NUM
cusj-10288	542	3	]	]	SYM
cusj-10288	542	4	bartl	bartl	NOUN
cusj-10288	542	5	,	,	PUNCT
cusj-10288	542	6	s.	s.	PROPN
cusj-10288	542	7	,	,	PUNCT
cusj-10288	542	8	oueslati	oueslati	PROPN
cusj-10288	542	9	,	,	PUNCT
cusj-10288	542	10	a.	a.	PROPN
cusj-10288	542	11	,	,	PUNCT
cusj-10288	542	12	southwell	southwell	PROPN
cusj-10288	542	13	,	,	PUNCT
cusj-10288	542	14	a.	a.	PROPN
cusj-10288	542	15	l.	l.	PROPN
cusj-10288	542	16	,	,	PUNCT
cusj-10288	542	17	siddu	siddu	PROPN
cusj-10288	542	18	,	,	PUNCT
cusj-10288	542	19	a.	a.	NOUN
cusj-10288	542	20	,	,	PUNCT
cusj-10288	542	21	parth	parth	NOUN
cusj-10288	542	22	,	,	PUNCT
cusj-10288	542	23	m.	m.	NOUN
cusj-10288	542	24	,	,	PUNCT
cusj-10288	542	25	david	david	PROPN
cusj-10288	542	26	,	,	PUNCT
cusj-10288	542	27	l.	l.	PROPN
cusj-10288	542	28	s.	s.	PROPN
cusj-10288	542	29	,	,	PUNCT
cusj-10288	542	30	maxan	maxan	PROPN
cusj-10288	542	31	,	,	PUNCT
cusj-10288	542	32	a.	a.	NOUN
cusj-10288	542	33	,	,	PUNCT
cusj-10288	542	34	salhat	salhat	NOUN
cusj-10288	542	35	,	,	PUNCT
cusj-10288	542	36	n.	n.	NOUN
cusj-10288	542	37	,	,	PUNCT
cusj-10288	542	38	burkert	burkert	NOUN
cusj-10288	542	39	,	,	PUNCT
cusj-10288	542	40	m.	m.	NOUN
cusj-10288	542	41	,	,	PUNCT
cusj-10288	542	42	mairhofer	mairhofer	NOUN
cusj-10288	542	43	,	,	PUNCT
cusj-10288	542	44	a.	a.	NOUN
cusj-10288	542	45	,	,	PUNCT
cusj-10288	542	46	friedrich	friedrich	NOUN
cusj-10288	542	47	,	,	PUNCT
cusj-10288	542	48	t.	t.	PROPN
cusj-10288	542	49	,	,	PUNCT
cusj-10288	542	50	pankevych	pankevych	NOUN
cusj-10288	542	51	,	,	PUNCT
cusj-10288	542	52	h.	h.	PROPN
cusj-10288	542	53	,	,	PUNCT
cusj-10288	542	54	balazs	balazs	PROPN
cusj-10288	542	55	,	,	PUNCT
cusj-10288	542	56	k.	k.	PROPN
cusj-10288	542	57	,	,	PUNCT
cusj-10288	542	58	staffler	staffler	NOUN
cusj-10288	542	59	,	,	PUNCT
cusj-10288	542	60	g.	g.	PROPN
cusj-10288	542	61	,	,	PUNCT
cusj-10288	542	62	hayden	hayden	PROPN
cusj-10288	542	63	,	,	PUNCT
cusj-10288	542	64	m.	m.	PROPN
cusj-10288	542	65	r.	r.	PROPN
cusj-10288	542	66	,	,	PUNCT
cusj-10288	542	67	cicchetti	cicchetti	PROPN
cusj-10288	542	68	,	,	PUNCT
cusj-10288	542	69	f.	f.	PROPN
cusj-10288	542	70	,	,	PUNCT
cusj-10288	542	71	&	&	CCONJ
cusj-10288	542	72	smrzka	smrzka	PROPN
cusj-10288	542	73	,	,	PUNCT
cusj-10288	542	74	o.	o.	PROPN
cusj-10288	542	75	w.	w.	PROPN
cusj-10288	542	76	(	(	PUNCT
cusj-10288	542	77	2020	2020	NUM
cusj-10288	542	78	)	)	PUNCT
cusj-10288	542	79	.	.	PUNCT
cusj-10288	543	1	inhibiting	inhibit	VERB
cusj-10288	543	2	cellular	cellular	ADJ
cusj-10288	543	3	uptake	uptake	NOUN
cusj-10288	543	4	of	of	ADP
cusj-10288	543	5	mutant	mutant	ADJ
cusj-10288	543	6	huntingtin	huntingtin	NOUN
cusj-10288	543	7	using	use	VERB
cusj-10288	543	8	a	a	DET
cusj-10288	543	9	monoclonal	monoclonal	NOUN
cusj-10288	543	10	antibody	antibody	NOUN
cusj-10288	543	11	:	:	PUNCT
cusj-10288	543	12	implications	implication	NOUN
cusj-10288	543	13	for	for	ADP
cusj-10288	543	14	the	the	DET
cusj-10288	543	15	treatment	treatment	NOUN
cusj-10288	543	16	of	of	ADP
cusj-10288	543	17	huntington	huntington	PROPN
cusj-10288	543	18	's	's	PART
cusj-10288	543	19	disease	disease	NOUN
cusj-10288	543	20	.	.	PUNCT
cusj-10288	544	1	neurobiology	neurobiology	NOUN
cusj-10288	544	2	of	of	ADP
cusj-10288	544	3	disease	disease	NOUN
cusj-10288	544	4	,	,	PUNCT
cusj-10288	544	5	141	141	NUM
cusj-10288	544	6	,	,	PUNCT
cusj-10288	544	7	104943	104943	NUM
cusj-10288	544	8	.	.	PUNCT
cusj-10288	545	1	https://doi.org/10.1016/j.nbd.2020.104943	https://doi.org/10.1016/j.nbd.2020.104943	PROPN
cusj-10288	545	2	columbia	columbia	PROPN
cusj-10288	545	3	undergraduate	undergraduate	PROPN
cusj-10288	545	4	science	science	PROPN
cusj-10288	545	5	journal	journal	PROPN
cusj-10288	545	6	vol	vol	NOUN
cusj-10288	545	7	.	.	PROPN
cusj-10288	545	8	17	17	NUM
cusj-10288	545	9	,	,	PUNCT
cusj-10288	545	10	2023	2023	NUM
cusj-10288	545	11	datta	datta	NOUN
cusj-10288	545	12	34	34	NUM
cusj-10288	546	1	[	[	NOUN
cusj-10288	546	2	85	85	NUM
cusj-10288	546	3	]	]	X
cusj-10288	546	4	fritz	fritz	NOUN
cusj-10288	546	5	,	,	PUNCT
cusj-10288	546	6	n.	n.	PROPN
cusj-10288	546	7	e.	e.	PROPN
cusj-10288	546	8	,	,	PUNCT
cusj-10288	546	9	rao	rao	PROPN
cusj-10288	546	10	,	,	PUNCT
cusj-10288	546	11	a.	a.	PROPN
cusj-10288	546	12	k.	k.	PROPN
cusj-10288	546	13	,	,	PUNCT
cusj-10288	546	14	kegelmeyer	kegelmeyer	PROPN
cusj-10288	546	15	,	,	PUNCT
cusj-10288	546	16	d.	d.	PROPN
cusj-10288	546	17	,	,	PUNCT
cusj-10288	546	18	kloos	kloos	PROPN
cusj-10288	546	19	,	,	PUNCT
cusj-10288	546	20	a.	a.	PROPN
cusj-10288	546	21	,	,	PUNCT
cusj-10288	546	22	busse	busse	PROPN
cusj-10288	546	23	,	,	PUNCT
cusj-10288	546	24	m.	m.	NOUN
cusj-10288	546	25	,	,	PUNCT
cusj-10288	546	26	hartel	hartel	PROPN
cusj-10288	546	27	,	,	PUNCT
cusj-10288	546	28	l.	l.	PROPN
cusj-10288	546	29	,	,	PUNCT
cusj-10288	546	30	carrier	carrier	NOUN
cusj-10288	546	31	,	,	PUNCT
cusj-10288	546	32	j.	j.	PROPN
cusj-10288	546	33	,	,	PUNCT
cusj-10288	546	34	&	&	CCONJ
cusj-10288	546	35	quinn	quinn	PROPN
cusj-10288	546	36	,	,	PUNCT
cusj-10288	546	37	l.	l.	PROPN
cusj-10288	546	38	(	(	PUNCT
cusj-10288	546	39	2017	2017	NUM
cusj-10288	546	40	)	)	PUNCT
cusj-10288	546	41	.	.	PUNCT
cusj-10288	547	1	physical	physical	ADJ
cusj-10288	547	2	therapy	therapy	NOUN
cusj-10288	547	3	and	and	CCONJ
cusj-10288	547	4	exercise	exercise	NOUN
cusj-10288	547	5	interventions	intervention	NOUN
cusj-10288	547	6	in	in	ADP
cusj-10288	547	7	huntington	huntington	PROPN
cusj-10288	547	8	's	's	PART
cusj-10288	547	9	disease	disease	NOUN
cusj-10288	547	10	:	:	PUNCT
cusj-10288	547	11	a	a	DET
cusj-10288	547	12	mixed	mixed	ADJ
cusj-10288	547	13	methods	method	NOUN
cusj-10288	547	14	systematic	systematic	PROPN
cusj-10288	547	15	review	review	PROPN
cusj-10288	547	16	.	.	PUNCT
cusj-10288	548	1	journal	journal	PROPN
cusj-10288	548	2	of	of	ADP
cusj-10288	548	3	huntington	huntington	PROPN
cusj-10288	548	4	's	's	PART
cusj-10288	548	5	disease	disease	NOUN
cusj-10288	548	6	,	,	PUNCT
cusj-10288	548	7	6(3	6(3	NOUN
cusj-10288	548	8	)	)	PUNCT
cusj-10288	548	9	,	,	PUNCT
cusj-10288	548	10	217–235	217–235	NUM
cusj-10288	548	11	.	.	PUNCT
cusj-10288	549	1	https://doi.org/10.3233/jhd-170260	https://doi.org/10.3233/jhd-170260	PROPN
cusj-10288	550	1	[	[	X
cusj-10288	550	2	86	86	NUM
cusj-10288	550	3	]	]	X
cusj-10288	550	4	nopoulos	nopoulos	PROPN
cusj-10288	550	5	p.	p.	PROPN
cusj-10288	550	6	c.	c.	PROPN
cusj-10288	550	7	(	(	PUNCT
cusj-10288	550	8	2016	2016	NUM
cusj-10288	550	9	)	)	PUNCT
cusj-10288	550	10	.	.	PUNCT
cusj-10288	551	1	huntington	huntington	PROPN
cusj-10288	551	2	disease	disease	PROPN
cusj-10288	551	3	:	:	PUNCT
cusj-10288	551	4	a	a	DET
cusj-10288	551	5	single	single	ADJ
cusj-10288	551	6	-	-	PUNCT
cusj-10288	551	7	gene	gene	NOUN
cusj-10288	551	8	degenerative	degenerative	ADJ
cusj-10288	551	9	disorder	disorder	NOUN
cusj-10288	551	10	of	of	ADP
cusj-10288	551	11	the	the	DET
cusj-10288	551	12	striatum	striatum	NOUN
cusj-10288	551	13	.	.	PUNCT
cusj-10288	552	1	dialogues	dialogue	NOUN
cusj-10288	552	2	in	in	ADP
cusj-10288	552	3	clinical	clinical	ADJ
cusj-10288	552	4	neuroscience	neuroscience	NOUN
cusj-10288	552	5	,	,	PUNCT
cusj-10288	552	6	18(1	18(1	NUM
cusj-10288	552	7	)	)	PUNCT
cusj-10288	552	8	,	,	PUNCT
cusj-10288	552	9	91–98	91–98	NUM
cusj-10288	552	10	.	.	PUNCT
cusj-10288	553	1	https://doi.org/10.31887/dcns.2016.18.1/pn	https://doi.org/10.31887/dcns.2016.18.1/pn	PROPN
cusj-10288	553	2	opoulos	opoulos	PROPN
cusj-10288	553	3	.	.	PUNCT
cusj-10288	554	1	[	[	X
cusj-10288	554	2	87	87	NUM
cusj-10288	554	3	]	]	SYM
cusj-10288	554	4	shannon	shannon	PROPN
cusj-10288	554	5	,	,	PUNCT
cusj-10288	554	6	k.	k.	PROPN
cusj-10288	554	7	m.	m.	PROPN
cusj-10288	554	8	,	,	PUNCT
cusj-10288	554	9	&	&	CCONJ
cusj-10288	554	10	fraint	fraint	PROPN
cusj-10288	554	11	,	,	PUNCT
cusj-10288	554	12	a.	a.	NOUN
cusj-10288	554	13	(	(	PUNCT
cusj-10288	554	14	2015	2015	NUM
cusj-10288	554	15	)	)	PUNCT
cusj-10288	554	16	.	.	PUNCT
cusj-10288	555	1	therapeutic	therapeutic	ADJ
cusj-10288	555	2	advances	advance	NOUN
cusj-10288	555	3	in	in	ADP
cusj-10288	555	4	huntington	huntington	PROPN
cusj-10288	555	5	's	's	PART
cusj-10288	555	6	disease	disease	NOUN
cusj-10288	555	7	.	.	PUNCT
cusj-10288	556	1	movement	movement	NOUN
cusj-10288	556	2	disorders	disorder	NOUN
cusj-10288	556	3	:	:	PUNCT
cusj-10288	556	4	official	official	ADJ
cusj-10288	556	5	journal	journal	NOUN
cusj-10288	556	6	of	of	ADP
cusj-10288	556	7	the	the	DET
cusj-10288	556	8	movement	movement	NOUN
cusj-10288	556	9	disorder	disorder	NOUN
cusj-10288	556	10	society	society	NOUN
cusj-10288	556	11	,	,	PUNCT
cusj-10288	556	12	30(11	30(11	NUM
cusj-10288	556	13	)	)	PUNCT
cusj-10288	556	14	,	,	PUNCT
cusj-10288	556	15	1539–1546	1539–1546	NUM
cusj-10288	556	16	.	.	PUNCT
cusj-10288	557	1	https://doi.org/10.1002/mds.26331	https://doi.org/10.1002/mds.26331	NOUN
cusj-10288	557	2	.	.	PUNCT
cusj-10288	558	1	[	[	X
cusj-10288	558	2	88	88	NUM
cusj-10288	558	3	]	]	SYM
cusj-10288	558	4	paulsen	paulsen	PROPN
cusj-10288	558	5	,	,	PUNCT
cusj-10288	558	6	j.	j.	PROPN
cusj-10288	558	7	s.	s.	PROPN
cusj-10288	558	8	,	,	PUNCT
cusj-10288	558	9	long	long	ADV
cusj-10288	558	10	,	,	PUNCT
cusj-10288	558	11	j.	j.	PROPN
cusj-10288	558	12	d.	d.	PROPN
cusj-10288	558	13	,	,	PUNCT
cusj-10288	558	14	johnson	johnson	PROPN
cusj-10288	558	15	,	,	PUNCT
cusj-10288	558	16	h.	h.	PROPN
cusj-10288	558	17	j.	j.	PROPN
cusj-10288	558	18	,	,	PUNCT
cusj-10288	558	19	aylward	aylward	PROPN
cusj-10288	558	20	,	,	PUNCT
cusj-10288	558	21	e.	e.	PROPN
cusj-10288	558	22	h.	h.	PROPN
cusj-10288	558	23	,	,	PUNCT
cusj-10288	558	24	ross	ross	PROPN
cusj-10288	558	25	,	,	PUNCT
cusj-10288	558	26	c.	c.	PROPN
cusj-10288	558	27	a.	a.	PROPN
cusj-10288	558	28	,	,	PUNCT
cusj-10288	558	29	williams	williams	PROPN
cusj-10288	558	30	,	,	PUNCT
cusj-10288	558	31	j.	j.	PROPN
cusj-10288	558	32	k.	k.	PROPN
cusj-10288	558	33	,	,	PUNCT
cusj-10288	558	34	nance	nance	NOUN
cusj-10288	558	35	,	,	PUNCT
cusj-10288	558	36	m.	m.	NOUN
cusj-10288	558	37	a.	a.	PROPN
cusj-10288	558	38	,	,	PUNCT
cusj-10288	558	39	erwin	erwin	PROPN
cusj-10288	558	40	,	,	PUNCT
cusj-10288	558	41	c.	c.	PROPN
cusj-10288	558	42	j.	j.	PROPN
cusj-10288	558	43	,	,	PUNCT
cusj-10288	558	44	westervelt	westervelt	PROPN
cusj-10288	558	45	,	,	PUNCT
cusj-10288	558	46	h.	h.	PROPN
cusj-10288	558	47	j.	j.	PROPN
cusj-10288	558	48	,	,	PUNCT
cusj-10288	558	49	harrington	harrington	PROPN
cusj-10288	558	50	,	,	PUNCT
cusj-10288	558	51	d.	d.	PROPN
cusj-10288	558	52	l.	l.	PROPN
cusj-10288	558	53	,	,	PUNCT
cusj-10288	558	54	bockholt	bockholt	PROPN
cusj-10288	558	55	,	,	PUNCT
cusj-10288	558	56	h.	h.	PROPN
cusj-10288	558	57	j.	j.	PROPN
cusj-10288	558	58	,	,	PUNCT
cusj-10288	558	59	zhang	zhang	PROPN
cusj-10288	558	60	,	,	PUNCT
cusj-10288	558	61	y.	y.	PROPN
cusj-10288	558	62	,	,	PUNCT
cusj-10288	558	63	mccusker	mccusker	PROPN
cusj-10288	558	64	,	,	PUNCT
cusj-10288	558	65	e.	e.	PROPN
cusj-10288	558	66	a.	a.	PROPN
cusj-10288	558	67	,	,	PUNCT
cusj-10288	558	68	chiu	chiu	PROPN
cusj-10288	558	69	,	,	PUNCT
cusj-10288	558	70	e.	e.	PROPN
cusj-10288	558	71	m.	m.	PROPN
cusj-10288	558	72	,	,	PUNCT
cusj-10288	558	73	panegyres	panegyre	VERB
cusj-10288	558	74	,	,	PUNCT
cusj-10288	558	75	p.	p.	PROPN
cusj-10288	558	76	k.	k.	PROPN
cusj-10288	558	77	,	,	PUNCT
cusj-10288	558	78	&	&	CCONJ
cusj-10288	558	79	predict	predict	VERB
cusj-10288	558	80	-	-	PUNCT
cusj-10288	558	81	hd	hd	VERB
cusj-10288	558	82	investigators	investigator	NOUN
cusj-10288	558	83	and	and	CCONJ
cusj-10288	558	84	coordinators	coordinator	NOUN
cusj-10288	558	85	of	of	ADP
cusj-10288	558	86	the	the	DET
cusj-10288	558	87	huntington	huntington	PROPN
cusj-10288	558	88	study	study	PROPN
cusj-10288	558	89	group	group	NOUN
cusj-10288	558	90	(	(	PUNCT
cusj-10288	558	91	2014	2014	NUM
cusj-10288	558	92	)	)	PUNCT
cusj-10288	558	93	.	.	PUNCT
cusj-10288	559	1	clinical	clinical	ADJ
cusj-10288	559	2	and	and	CCONJ
cusj-10288	559	3	biomarker	biomarker	NOUN
cusj-10288	559	4	changes	change	NOUN
cusj-10288	559	5	in	in	ADP
cusj-10288	559	6	premanifest	premanif	ADJ
cusj-10288	559	7	huntington	huntington	PROPN
cusj-10288	559	8	disease	disease	NOUN
cusj-10288	559	9	show	show	VERB
cusj-10288	559	10	trial	trial	NOUN
cusj-10288	559	11	feasibility	feasibility	NOUN
cusj-10288	559	12	:	:	PUNCT
cusj-10288	559	13	a	a	DET
cusj-10288	559	14	decade	decade	NOUN
cusj-10288	559	15	of	of	ADP
cusj-10288	559	16	the	the	DET
cusj-10288	559	17	predict	predict	ADJ
cusj-10288	559	18	-	-	PUNCT
cusj-10288	559	19	hd	hd	NOUN
cusj-10288	559	20	study	study	NOUN
cusj-10288	559	21	.	.	PUNCT
cusj-10288	560	1	frontiers	frontier	NOUN
cusj-10288	560	2	in	in	ADP
cusj-10288	560	3	aging	age	VERB
cusj-10288	560	4	neuroscience	neuroscience	NOUN
cusj-10288	560	5	,	,	PUNCT
cusj-10288	560	6	6	6	NUM
cusj-10288	560	7	,	,	PUNCT
cusj-10288	560	8	78	78	NUM
cusj-10288	560	9	.	.	PUNCT
cusj-10288	561	1	https://doi.org/10.3389/fnagi.2014.00078	https://doi.org/10.3389/fnagi.2014.00078	NOUN
cusj-10288	561	2	.	.	PUNCT
cusj-10288	562	1	[	[	X
cusj-10288	562	2	89	89	NUM
cusj-10288	562	3	]	]	X
cusj-10288	562	4	maxwell	maxwell	PROPN
cusj-10288	562	5	m.	m.	PROPN
cusj-10288	562	6	m.	m.	NOUN
cusj-10288	562	7	(	(	PUNCT
cusj-10288	562	8	2009	2009	NUM
cusj-10288	562	9	)	)	PUNCT
cusj-10288	562	10	.	.	PUNCT
cusj-10288	563	1	rnai	rnai	PROPN
cusj-10288	563	2	applications	application	NOUN
cusj-10288	563	3	in	in	ADP
cusj-10288	563	4	therapy	therapy	NOUN
cusj-10288	563	5	development	development	NOUN
cusj-10288	563	6	for	for	ADP
cusj-10288	563	7	neurodegenerative	neurodegenerative	ADJ
cusj-10288	563	8	disease	disease	NOUN
cusj-10288	563	9	.	.	PUNCT
cusj-10288	564	1	current	current	ADJ
cusj-10288	564	2	pharmaceutical	pharmaceutical	ADJ
cusj-10288	564	3	design	design	NOUN
cusj-10288	564	4	,	,	PUNCT
cusj-10288	564	5	15(34	15(34	NUM
cusj-10288	564	6	)	)	PUNCT
cusj-10288	564	7	,	,	PUNCT
cusj-10288	564	8	3977–3991	3977–3991	NUM
cusj-10288	564	9	.	.	PUNCT
cusj-10288	565	1	https://doi.org/10.2174/13816120978964929	https://doi.org/10.2174/13816120978964929	NOUN
cusj-10288	565	2	5	5	NUM
cusj-10288	565	3	.	.	PUNCT
cusj-10288	566	1	[	[	X
cusj-10288	566	2	90	90	NUM
cusj-10288	566	3	]	]	PUNCT
cusj-10288	566	4	beal	beal	NOUN
cusj-10288	566	5	,	,	PUNCT
cusj-10288	566	6	m.	m.	PROPN
cusj-10288	566	7	f.	f.	PROPN
cusj-10288	566	8	,	,	PUNCT
cusj-10288	566	9	ferrante	ferrante	PROPN
cusj-10288	566	10	,	,	PUNCT
cusj-10288	566	11	r.	r.	PROPN
cusj-10288	566	12	j.	j.	PROPN
cusj-10288	566	13	,	,	PUNCT
cusj-10288	566	14	swartz	swartz	PROPN
cusj-10288	566	15	,	,	PUNCT
cusj-10288	566	16	k.	k.	PROPN
cusj-10288	566	17	j.	j.	PROPN
cusj-10288	566	18	,	,	PUNCT
cusj-10288	566	19	&	&	CCONJ
cusj-10288	566	20	kowall	kowall	PROPN
cusj-10288	566	21	,	,	PUNCT
cusj-10288	566	22	n.	n.	PROPN
cusj-10288	566	23	w.	w.	PROPN
cusj-10288	566	24	(	(	PUNCT
cusj-10288	566	25	1991	1991	NUM
cusj-10288	566	26	)	)	PUNCT
cusj-10288	566	27	.	.	PUNCT
cusj-10288	567	1	chronic	chronic	ADJ
cusj-10288	567	2	quinolinic	quinolinic	ADJ
cusj-10288	567	3	acid	acid	NOUN
cusj-10288	567	4	lesions	lesion	NOUN
cusj-10288	567	5	in	in	ADP
cusj-10288	567	6	rats	rat	NOUN
cusj-10288	567	7	closely	closely	ADV
cusj-10288	567	8	resemble	resemble	VERB
cusj-10288	567	9	huntington	huntington	PROPN
cusj-10288	567	10	's	's	PART
cusj-10288	567	11	disease	disease	NOUN
cusj-10288	567	12	.	.	PUNCT
cusj-10288	568	1	the	the	DET
cusj-10288	568	2	journal	journal	NOUN
cusj-10288	568	3	of	of	ADP
cusj-10288	568	4	neuroscience	neuroscience	NOUN
cusj-10288	568	5	:	:	PUNCT
cusj-10288	568	6	the	the	DET
cusj-10288	568	7	official	official	ADJ
cusj-10288	568	8	journal	journal	NOUN
cusj-10288	568	9	of	of	ADP
cusj-10288	568	10	the	the	DET
cusj-10288	568	11	society	society	NOUN
cusj-10288	568	12	for	for	ADP
cusj-10288	568	13	neuroscience	neuroscience	NOUN
cusj-10288	568	14	,	,	PUNCT
cusj-10288	568	15	11(6	11(6	NUM
cusj-10288	568	16	)	)	PUNCT
cusj-10288	568	17	,	,	PUNCT
cusj-10288	568	18	1649–1659	1649–1659	NUM
cusj-10288	568	19	.	.	PUNCT
cusj-10288	569	1	https://doi.org/10.1523/jneurosci.11-0601649.1991	https://doi.org/10.1523/jneurosci.11-0601649.1991	PROPN
cusj-10288	569	2	.	.	PUNCT
cusj-10288	570	1	[	[	X
cusj-10288	570	2	91	91	NUM
cusj-10288	570	3	]	]	PUNCT
cusj-10288	570	4	rozas	rozas	PROPN
cusj-10288	570	5	,	,	PUNCT
cusj-10288	570	6	j.	j.	PROPN
cusj-10288	570	7	l.	l.	PROPN
cusj-10288	570	8	,	,	PUNCT
cusj-10288	570	9	gómez	gómez	NOUN
cusj-10288	570	10	-	-	PUNCT
cusj-10288	570	11	sánchez	sánchez	NOUN
cusj-10288	570	12	,	,	PUNCT
cusj-10288	570	13	l.	l.	PROPN
cusj-10288	570	14	,	,	PUNCT
cusj-10288	570	15	tomás	tomás	ADJ
cusj-10288	570	16	-	-	PUNCT
cusj-10288	570	17	zapico	zapico	NOUN
cusj-10288	570	18	,	,	PUNCT
cusj-10288	570	19	c.	c.	NOUN
cusj-10288	570	20	,	,	PUNCT
cusj-10288	570	21	lucas	lucas	PROPN
cusj-10288	570	22	,	,	PUNCT
cusj-10288	570	23	j.	j.	PROPN
cusj-10288	570	24	j.	j.	PROPN
cusj-10288	570	25	,	,	PUNCT
cusj-10288	570	26	&	&	CCONJ
cusj-10288	570	27	fernández	fernández	PROPN
cusj-10288	570	28	-	-	PUNCT
cusj-10288	570	29	chacón	chacón	PROPN
cusj-10288	570	30	,	,	PUNCT
cusj-10288	570	31	r.	r.	PROPN
cusj-10288	570	32	(	(	PUNCT
cusj-10288	570	33	2010	2010	NUM
cusj-10288	570	34	)	)	PUNCT
cusj-10288	570	35	.	.	PUNCT
cusj-10288	571	1	presynaptic	presynaptic	ADJ
cusj-10288	571	2	dysfunction	dysfunction	NOUN
cusj-10288	571	3	in	in	ADP
cusj-10288	571	4	huntington	huntington	PROPN
cusj-10288	571	5	's	's	PART
cusj-10288	571	6	disease	disease	NOUN
cusj-10288	571	7	.	.	PUNCT
cusj-10288	572	1	biochemical	biochemical	ADJ
cusj-10288	572	2	society	society	NOUN
cusj-10288	572	3	transactions	transaction	NOUN
cusj-10288	572	4	,	,	PUNCT
cusj-10288	572	5	38(2	38(2	NOUN
cusj-10288	572	6	)	)	PUNCT
cusj-10288	572	7	,	,	PUNCT
cusj-10288	572	8	488–492	488–492	NUM
cusj-10288	572	9	.	.	PUNCT
cusj-10288	573	1	https://doi.org/10.1042/bst0380488	https://doi.org/10.1042/bst0380488	NUM
cusj-10288	573	2	.	.	PUNCT
cusj-10288	574	1	[	[	X
cusj-10288	574	2	92	92	NUM
cusj-10288	574	3	]	]	X
cusj-10288	574	4	von	von	PROPN
cusj-10288	574	5	zastrow	zastrow	PROPN
cusj-10288	574	6	,	,	PUNCT
cusj-10288	574	7	m.	m.	NOUN
cusj-10288	574	8	,	,	PUNCT
cusj-10288	574	9	&	&	CCONJ
cusj-10288	574	10	sorkin	sorkin	PROPN
cusj-10288	574	11	,	,	PUNCT
cusj-10288	574	12	a.	a.	NOUN
cusj-10288	574	13	(	(	PUNCT
cusj-10288	574	14	2007	2007	NUM
cusj-10288	574	15	)	)	PUNCT
cusj-10288	574	16	.	.	PUNCT
cusj-10288	575	1	signaling	signal	VERB
cusj-10288	575	2	on	on	ADP
cusj-10288	575	3	the	the	DET
cusj-10288	575	4	endocytic	endocytic	ADJ
cusj-10288	575	5	pathway	pathway	NOUN
cusj-10288	575	6	.	.	PUNCT
cusj-10288	576	1	current	current	ADJ
cusj-10288	576	2	opinion	opinion	NOUN
cusj-10288	576	3	in	in	ADP
cusj-10288	576	4	cell	cell	NOUN
cusj-10288	576	5	biology	biology	NOUN
cusj-10288	576	6	,	,	PUNCT
cusj-10288	576	7	19(4	19(4	PROPN
cusj-10288	576	8	)	)	PUNCT
cusj-10288	576	9	,	,	PUNCT
cusj-10288	576	10	436–445	436–445	NOUN
cusj-10288	576	11	.	.	PUNCT
cusj-10288	577	1	https://doi.org/10.1016/j.ceb.2007.04.021	https://doi.org/10.1016/j.ceb.2007.04.021	NOUN
cusj-10288	577	2	.	.	PUNCT
cusj-10288	578	1	[	[	X
cusj-10288	578	2	93	93	NUM
cusj-10288	578	3	]	]	X
cusj-10288	578	4	hong	hong	PROPN
cusj-10288	578	5	,	,	PUNCT
cusj-10288	578	6	e.	e.	PROPN
cusj-10288	578	7	p.	p.	PROPN
cusj-10288	578	8	,	,	PUNCT
cusj-10288	578	9	macdonald	macdonald	PROPN
cusj-10288	578	10	,	,	PUNCT
cusj-10288	578	11	m.	m.	PROPN
cusj-10288	578	12	e.	e.	PROPN
cusj-10288	578	13	,	,	PUNCT
cusj-10288	578	14	wheeler	wheeler	NOUN
cusj-10288	578	15	,	,	PUNCT
cusj-10288	578	16	v.	v.	PROPN
cusj-10288	578	17	c.	c.	PROPN
cusj-10288	578	18	,	,	PUNCT
cusj-10288	578	19	jones	jones	PROPN
cusj-10288	578	20	,	,	PUNCT
cusj-10288	578	21	l.	l.	PROPN
cusj-10288	578	22	,	,	PUNCT
cusj-10288	578	23	holmans	holman	NOUN
cusj-10288	578	24	,	,	PUNCT
cusj-10288	578	25	p.	p.	NOUN
cusj-10288	578	26	,	,	PUNCT
cusj-10288	578	27	orth	orth	PROPN
cusj-10288	578	28	,	,	PUNCT
cusj-10288	578	29	m.	m.	NOUN
cusj-10288	578	30	,	,	PUNCT
cusj-10288	578	31	monckton	monckton	PROPN
cusj-10288	578	32	,	,	PUNCT
cusj-10288	578	33	d.	d.	PROPN
cusj-10288	578	34	g.	g.	PROPN
cusj-10288	578	35	,	,	PUNCT
cusj-10288	578	36	long	long	ADV
cusj-10288	578	37	,	,	PUNCT
cusj-10288	578	38	j.	j.	PROPN
cusj-10288	578	39	d.	d.	PROPN
cusj-10288	578	40	,	,	PUNCT
cusj-10288	578	41	kwak	kwak	PROPN
cusj-10288	578	42	,	,	PUNCT
cusj-10288	578	43	s.	s.	PROPN
cusj-10288	578	44	,	,	PUNCT
cusj-10288	578	45	gusella	gusella	PROPN
cusj-10288	578	46	,	,	PUNCT
cusj-10288	578	47	j.	j.	PROPN
cusj-10288	578	48	f.	f.	PROPN
cusj-10288	578	49	,	,	PUNCT
cusj-10288	578	50	&	&	CCONJ
cusj-10288	578	51	lee	lee	PROPN
cusj-10288	578	52	,	,	PUNCT
cusj-10288	578	53	j.	j.	PROPN
cusj-10288	578	54	m.	m.	PROPN
cusj-10288	578	55	(	(	PUNCT
cusj-10288	578	56	2021	2021	NUM
cusj-10288	578	57	)	)	PUNCT
cusj-10288	578	58	.	.	PUNCT
cusj-10288	579	1	huntington	huntington	PROPN
cusj-10288	579	2	's	's	PART
cusj-10288	579	3	disease	disease	NOUN
cusj-10288	579	4	pathogenesis	pathogenesis	NOUN
cusj-10288	579	5	:	:	PUNCT
cusj-10288	579	6	two	two	NUM
cusj-10288	579	7	sequential	sequential	ADJ
cusj-10288	579	8	components	component	NOUN
cusj-10288	579	9	.	.	PUNCT
cusj-10288	580	1	journal	journal	PROPN
cusj-10288	580	2	of	of	ADP
cusj-10288	580	3	huntington	huntington	PROPN
cusj-10288	580	4	's	's	PART
cusj-10288	580	5	disease	disease	NOUN
cusj-10288	580	6	,	,	PUNCT
cusj-10288	580	7	10(1	10(1	NUM
cusj-10288	580	8	)	)	PUNCT
cusj-10288	580	9	,	,	PUNCT
cusj-10288	580	10	35–51	35–51	NUM
cusj-10288	580	11	.	.	PUNCT
cusj-10288	581	1	https://doi.org/10.3233/jhd-200427	https://doi.org/10.3233/jhd-200427	AUX
cusj-10288	581	2	.	.	PUNCT