id	sid	tid	token	lemma	pos
cusj-12940	1	1	16	16	NUM
cusj-12940	1	2	introduction	introduction	NOUN
cusj-12940	1	3	glioblastomas	glioblastoma	NOUN
cusj-12940	1	4	(	(	PUNCT
cusj-12940	1	5	gbm	gbm	PROPN
cusj-12940	1	6	)	)	PUNCT
cusj-12940	1	7	are	be	AUX
cusj-12940	1	8	grade	grade	NOUN
cusj-12940	1	9	iv	iv	NUM
cusj-12940	1	10	gliomas	glioma	NOUN
cusj-12940	1	11	and	and	CCONJ
cusj-12940	1	12	are	be	AUX
cusj-12940	1	13	the	the	DET
cusj-12940	1	14	most	most	ADV
cusj-12940	1	15	lethal	lethal	ADJ
cusj-12940	1	16	primary	primary	ADJ
cusj-12940	1	17	malignancy	malignancy	NOUN
cusj-12940	1	18	of	of	ADP
cusj-12940	1	19	the	the	DET
cusj-12940	1	20	central	central	ADJ
cusj-12940	1	21	nervous	nervous	ADJ
cusj-12940	1	22	system	system	NOUN
cusj-12940	1	23	(	(	PUNCT
cusj-12940	1	24	cns	cns	NOUN
cusj-12940	1	25	)	)	PUNCT
cusj-12940	1	26	.	.	PUNCT
cusj-12940	2	1	despite	despite	SCONJ
cusj-12940	2	2	comprising	comprise	VERB
cusj-12940	2	3	54	54	NUM
cusj-12940	2	4	%	%	NOUN
cusj-12940	2	5	of	of	ADP
cusj-12940	2	6	all	all	DET
cusj-12940	2	7	gliomas	glioma	NOUN
cusj-12940	2	8	and	and	CCONJ
cusj-12940	2	9	16	16	NUM
cusj-12940	2	10	%	%	NOUN
cusj-12940	2	11	of	of	ADP
cusj-12940	2	12	all	all	DET
cusj-12940	2	13	primary	primary	ADJ
cusj-12940	2	14	brain	brain	NOUN
cusj-12940	2	15	tumors	tumor	NOUN
cusj-12940	2	16	,	,	PUNCT
cusj-12940	2	17	gbm	gbm	PROPN
cusj-12940	2	18	lacks	lack	VERB
cusj-12940	2	19	a	a	DET
cusj-12940	2	20	cure	cure	NOUN
cusj-12940	2	21	and	and	CCONJ
cusj-12940	2	22	only	only	ADV
cusj-12940	2	23	has	have	VERB
cusj-12940	2	24	a	a	DET
cusj-12940	2	25	handful	handful	NOUN
cusj-12940	2	26	of	of	ADP
cusj-12940	2	27	treatments	treatment	NOUN
cusj-12940	2	28	[	[	X
cusj-12940	2	29	1	1	NUM
cusj-12940	2	30	]	]	PUNCT
cusj-12940	2	31	.	.	PUNCT
cusj-12940	3	1	the	the	DET
cusj-12940	3	2	lack	lack	NOUN
cusj-12940	3	3	of	of	ADP
cusj-12940	3	4	curative	curative	ADJ
cusj-12940	3	5	treatment	treatment	NOUN
cusj-12940	3	6	for	for	ADP
cusj-12940	3	7	gbm	gbm	NOUN
cusj-12940	3	8	can	can	AUX
cusj-12940	3	9	be	be	AUX
cusj-12940	3	10	attributed	attribute	VERB
cusj-12940	3	11	to	to	ADP
cusj-12940	3	12	several	several	ADJ
cusj-12940	3	13	factors	factor	NOUN
cusj-12940	3	14	,	,	PUNCT
cusj-12940	3	15	some	some	PRON
cusj-12940	3	16	of	of	ADP
cusj-12940	3	17	which	which	PRON
cusj-12940	3	18	being	be	AUX
cusj-12940	3	19	high	high	ADJ
cusj-12940	3	20	gbm	gbm	NOUN
cusj-12940	3	21	resistance	resistance	NOUN
cusj-12940	3	22	rates	rate	NOUN
cusj-12940	3	23	,	,	PUNCT
cusj-12940	3	24	rapid	rapid	ADJ
cusj-12940	3	25	angiogenesis	angiogenesis	NOUN
cusj-12940	3	26	,	,	PUNCT
cusj-12940	3	27	and	and	CCONJ
cusj-12940	3	28	vast	vast	ADJ
cusj-12940	3	29	spread	spread	NOUN
cusj-12940	3	30	[	[	X
cusj-12940	3	31	10	10	NUM
cusj-12940	3	32	]	]	PUNCT
cusj-12940	3	33	.	.	PUNCT
cusj-12940	4	1	studies	study	NOUN
cusj-12940	4	2	have	have	AUX
cusj-12940	4	3	demonstrated	demonstrate	VERB
cusj-12940	4	4	that	that	SCONJ
cusj-12940	4	5	,	,	PUNCT
cusj-12940	4	6	unlike	unlike	ADP
cusj-12940	4	7	non	non	ADJ
cusj-12940	4	8	-	-	ADJ
cusj-12940	4	9	tumorigenic	tumorigenic	ADJ
cusj-12940	4	10	cells	cell	NOUN
cusj-12940	4	11	–	–	PUNCT
cusj-12940	4	12	which	which	PRON
cusj-12940	4	13	have	have	VERB
cusj-12940	4	14	extracellular	extracellular	ADJ
cusj-12940	4	15	ph	ph	NOUN
cusj-12940	4	16	(	(	PUNCT
cusj-12940	4	17	phe	phe	NOUN
cusj-12940	4	18	)	)	PUNCT
cusj-12940	4	19	of	of	ADP
cusj-12940	4	20	approximately	approximately	ADV
cusj-12940	4	21	7.4	7.4	NUM
cusj-12940	4	22	–	–	PUNCT
cusj-12940	4	23	gbm	gbm	NOUN
cusj-12940	4	24	have	have	VERB
cusj-12940	4	25	acidic	acidic	ADJ
cusj-12940	4	26	phe	phe	NOUN
cusj-12940	4	27	ranging	range	VERB
cusj-12940	4	28	between	between	ADP
cusj-12940	4	29	6.7	6.7	NUM
cusj-12940	4	30	-	-	SYM
cusj-12940	4	31	7.1	7.1	NUM
cusj-12940	4	32	[	[	X
cusj-12940	4	33	3	3	NUM
cusj-12940	4	34	]	]	PUNCT
cusj-12940	4	35	.	.	PUNCT
cusj-12940	5	1	this	this	DET
cusj-12940	5	2	acidic	acidic	ADJ
cusj-12940	5	3	extracellular	extracellular	ADJ
cusj-12940	5	4	ph	ph	NOUN
cusj-12940	5	5	has	have	AUX
cusj-12940	5	6	recently	recently	ADV
cusj-12940	5	7	been	be	AUX
cusj-12940	5	8	demonstrated	demonstrate	VERB
cusj-12940	5	9	to	to	PART
cusj-12940	5	10	activate	activate	VERB
cusj-12940	5	11	proteases	protease	NOUN
cusj-12940	5	12	(	(	PUNCT
cusj-12940	5	13	such	such	ADJ
cusj-12940	5	14	as	as	ADP
cusj-12940	5	15	serine	serine	ADJ
cusj-12940	5	16	proteases	protease	NOUN
cusj-12940	5	17	,	,	PUNCT
cusj-12940	5	18	plasminogen	plasminogen	NOUN
cusj-12940	5	19	activators	activator	NOUN
cusj-12940	5	20	,	,	PUNCT
cusj-12940	5	21	and	and	CCONJ
cusj-12940	5	22	metalloproteinases	metalloproteinase	NOUN
cusj-12940	5	23	)	)	PUNCT
cusj-12940	5	24	.	.	PUNCT
cusj-12940	6	1	these	these	DET
cusj-12940	6	2	proteases	protease	NOUN
cusj-12940	6	3	degrade	degrade	VERB
cusj-12940	6	4	the	the	DET
cusj-12940	6	5	gbm	gbm	PROPN
cusj-12940	6	6	extracellular	extracellular	PROPN
cusj-12940	6	7	environment	environment	NOUN
cusj-12940	6	8	,	,	PUNCT
cusj-12940	6	9	explaining	explain	VERB
cusj-12940	6	10	why	why	SCONJ
cusj-12940	6	11	they	they	PRON
cusj-12940	6	12	have	have	AUX
cusj-12940	6	13	been	be	AUX
cusj-12940	6	14	indicated	indicate	VERB
cusj-12940	6	15	to	to	PART
cusj-12940	6	16	be	be	AUX
cusj-12940	6	17	involved	involve	VERB
cusj-12940	6	18	in	in	ADP
cusj-12940	6	19	gbm	gbm	NOUN
cusj-12940	6	20	growth	growth	NOUN
cusj-12940	6	21	,	,	PUNCT
cusj-12940	6	22	invasion	invasion	NOUN
cusj-12940	6	23	,	,	PUNCT
cusj-12940	6	24	angiogenesis	angiogenesis	NOUN
cusj-12940	6	25	and	and	CCONJ
cusj-12940	6	26	metastasis	metastasis	PRON
cusj-12940	6	27	[	[	X
cusj-12940	6	28	2	2	NUM
cusj-12940	6	29	,	,	PUNCT
cusj-12940	6	30	4	4	NUM
cusj-12940	6	31	]	]	PUNCT
cusj-12940	6	32	.	.	PUNCT
cusj-12940	7	1	given	give	VERB
cusj-12940	7	2	the	the	DET
cusj-12940	7	3	importance	importance	NOUN
cusj-12940	7	4	of	of	ADP
cusj-12940	7	5	ph	ph	NOUN
cusj-12940	7	6	in	in	ADP
cusj-12940	7	7	gbm	gbm	NOUN
cusj-12940	7	8	progression	progression	NOUN
cusj-12940	7	9	,	,	PUNCT
cusj-12940	7	10	this	this	DET
cusj-12940	7	11	study	study	NOUN
cusj-12940	7	12	aimed	aim	VERB
cusj-12940	7	13	to	to	PART
cusj-12940	7	14	focus	focus	VERB
cusj-12940	7	15	on	on	ADP
cusj-12940	7	16	ph	ph	ADJ
cusj-12940	7	17	regulation	regulation	NOUN
cusj-12940	7	18	as	as	ADP
cusj-12940	7	19	a	a	DET
cusj-12940	7	20	means	means	NOUN
cusj-12940	7	21	of	of	ADP
cusj-12940	7	22	gbm	gbm	PROPN
cusj-12940	7	23	treatment	treatment	NOUN
cusj-12940	7	24	.	.	PUNCT
cusj-12940	8	1	a	a	DET
cusj-12940	8	2	major	major	ADJ
cusj-12940	8	3	regulator	regulator	NOUN
cusj-12940	8	4	of	of	ADP
cusj-12940	8	5	physiological	physiological	ADJ
cusj-12940	8	6	ph	ph	NOUN
cusj-12940	8	7	is	be	AUX
cusj-12940	8	8	the	the	DET
cusj-12940	8	9	vacuolar	vacuolar	ADJ
cusj-12940	8	10	(	(	PUNCT
cusj-12940	8	11	h+)-atpase	h+)-atpase	PROPN
cusj-12940	8	12	(	(	PUNCT
cusj-12940	8	13	v	v	NOUN
cusj-12940	8	14	-	-	PUNCT
cusj-12940	8	15	atpase	atpase	NOUN
cusj-12940	8	16	)	)	PUNCT
cusj-12940	8	17	.	.	PUNCT
cusj-12940	9	1	v	v	X
cusj-12940	9	2	-	-	PUNCT
cusj-12940	9	3	atpases	atpase	NOUN
cusj-12940	9	4	are	be	AUX
cusj-12940	9	5	ubiquitously	ubiquitously	ADV
cusj-12940	9	6	expressed	express	VERB
cusj-12940	9	7	and	and	CCONJ
cusj-12940	9	8	can	can	AUX
cusj-12940	9	9	be	be	AUX
cusj-12940	9	10	found	find	VERB
cusj-12940	9	11	in	in	ADP
cusj-12940	9	12	lysosomes	lysosome	NOUN
cusj-12940	9	13	,	,	PUNCT
cusj-12940	9	14	exploring	explore	VERB
cusj-12940	9	15	the	the	DET
cusj-12940	9	16	“	"	PUNCT
cusj-12940	9	17	cascade	cascade	NOUN
cusj-12940	9	18	effect	effect	NOUN
cusj-12940	9	19	”	"	PUNCT
cusj-12940	9	20	of	of	ADP
cusj-12940	9	21	aebsf	aebsf	ADV
cusj-12940	9	22	on	on	ADP
cusj-12940	9	23	reduced	reduce	VERB
cusj-12940	9	24	glioblastoma	glioblastoma	NOUN
cusj-12940	9	25	proliferation	proliferation	NOUN
cusj-12940	9	26	mehwish	mehwish	PROPN
cusj-12940	9	27	mirza	mirza	PROPN
cusj-12940	10	1	©	©	PROPN
cusj-12940	10	2	2022	2022	NUM
cusj-12940	10	3	mirza	mirza	PROPN
cusj-12940	10	4	.	.	PUNCT
cusj-12940	11	1	this	this	PRON
cusj-12940	11	2	is	be	AUX
cusj-12940	11	3	an	an	DET
cusj-12940	11	4	open	open	ADJ
cusj-12940	11	5	access	access	NOUN
cusj-12940	11	6	article	article	NOUN
cusj-12940	11	7	distributed	distribute	VERB
cusj-12940	11	8	under	under	ADP
cusj-12940	11	9	the	the	DET
cusj-12940	11	10	terms	term	NOUN
cusj-12940	11	11	of	of	ADP
cusj-12940	11	12	the	the	DET
cusj-12940	11	13	creative	creative	ADJ
cusj-12940	11	14	commons	common	NOUN
cusj-12940	11	15	attribution	attribution	NOUN
cusj-12940	11	16	license	license	NOUN
cusj-12940	11	17	,	,	PUNCT
cusj-12940	11	18	which	which	PRON
cusj-12940	11	19	permits	permit	VERB
cusj-12940	11	20	the	the	DET
cusj-12940	11	21	user	user	NOUN
cusj-12940	11	22	to	to	PART
cusj-12940	11	23	copy	copy	VERB
cusj-12940	11	24	,	,	PUNCT
cusj-12940	11	25	distribute	distribute	VERB
cusj-12940	11	26	,	,	PUNCT
cusj-12940	11	27	and	and	CCONJ
cusj-12940	11	28	transmit	transmit	VERB
cusj-12940	11	29	the	the	DET
cusj-12940	11	30	work	work	NOUN
cusj-12940	11	31	provided	provide	VERB
cusj-12940	11	32	that	that	SCONJ
cusj-12940	11	33	the	the	DET
cusj-12940	11	34	original	original	ADJ
cusj-12940	11	35	authors	author	NOUN
cusj-12940	11	36	and	and	CCONJ
cusj-12940	11	37	source	source	NOUN
cusj-12940	11	38	are	be	AUX
cusj-12940	11	39	credited	credit	VERB
cusj-12940	11	40	.	.	PUNCT
cusj-12940	12	1	columbia	columbia	PROPN
cusj-12940	12	2	university	university	PROPN
cusj-12940	12	3	,	,	PUNCT
cusj-12940	12	4	new	new	PROPN
cusj-12940	12	5	york	york	PROPN
cusj-12940	12	6	,	,	PUNCT
cusj-12940	12	7	ny	ny	PROPN
cusj-12940	12	8	,	,	PUNCT
cusj-12940	12	9	usa	usa	PROPN
cusj-12940	12	10	keywords	keyword	NOUN
cusj-12940	12	11	:	:	PUNCT
cusj-12940	12	12	glioblastoma	glioblastoma	NOUN
cusj-12940	12	13	,	,	PUNCT
cusj-12940	12	14	aebsf	aebsf	ADV
cusj-12940	12	15	,	,	PUNCT
cusj-12940	12	16	v	v	NOUN
cusj-12940	12	17	-	-	PUNCT
cusj-12940	12	18	atpase	atpase	ADJ
cusj-12940	12	19	,	,	PUNCT
cusj-12940	12	20	cascade	cascade	NOUN
cusj-12940	12	21	effect	effect	NOUN
cusj-12940	12	22	,	,	PUNCT
cusj-12940	12	23	metalloproteinases	metalloproteinase	NOUN
cusj-12940	12	24	,	,	PUNCT
cusj-12940	12	25	cancer	cancer	NOUN
cusj-12940	12	26	proliferation	proliferation	NOUN
cusj-12940	12	27	,	,	PUNCT
cusj-12940	12	28	extracellular	extracellular	ADJ
cusj-12940	12	29	matrix	matrix	NOUN
cusj-12940	12	30	disassembly	disassembly	NOUN
cusj-12940	12	31	in	in	ADP
cusj-12940	12	32	cancer	cancer	NOUN
cusj-12940	12	33	abstract	abstract	NOUN
cusj-12940	12	34	:	:	PUNCT
cusj-12940	12	35	glioblastomas	glioblastoma	NOUN
cusj-12940	12	36	(	(	PUNCT
cusj-12940	12	37	gbms	gbms	PROPN
cusj-12940	12	38	)	)	PUNCT
cusj-12940	12	39	are	be	AUX
cusj-12940	12	40	one	one	NUM
cusj-12940	12	41	of	of	ADP
cusj-12940	12	42	the	the	DET
cusj-12940	12	43	deadliest	deadly	ADJ
cusj-12940	12	44	cancers	cancer	NOUN
cusj-12940	12	45	,	,	PUNCT
cusj-12940	12	46	and	and	CCONJ
cusj-12940	12	47	yet	yet	ADV
cusj-12940	12	48	still	still	ADV
cusj-12940	12	49	lack	lack	VERB
cusj-12940	12	50	treatment	treatment	NOUN
cusj-12940	12	51	.	.	PUNCT
cusj-12940	13	1	in	in	ADP
cusj-12940	13	2	this	this	DET
cusj-12940	13	3	study	study	NOUN
cusj-12940	13	4	,	,	PUNCT
cusj-12940	13	5	serine	serine	ADJ
cusj-12940	13	6	protease	protease	NOUN
cusj-12940	13	7	inhibitor	inhibitor	NOUN
cusj-12940	13	8	aebsf	aebsf	ADV
cusj-12940	13	9	is	be	AUX
cusj-12940	13	10	shown	show	VERB
cusj-12940	13	11	to	to	PART
cusj-12940	13	12	decrease	decrease	VERB
cusj-12940	13	13	gbm	gbm	NOUN
cusj-12940	13	14	viability	viability	NOUN
cusj-12940	13	15	and	and	CCONJ
cusj-12940	13	16	proliferation	proliferation	NOUN
cusj-12940	13	17	through	through	ADP
cusj-12940	13	18	a	a	DET
cusj-12940	13	19	series	series	NOUN
cusj-12940	13	20	of	of	ADP
cusj-12940	13	21	intertwined	intertwine	VERB
cusj-12940	13	22	steps	step	NOUN
cusj-12940	13	23	.	.	PUNCT
cusj-12940	14	1	by	by	ADP
cusj-12940	14	2	decreasing	decrease	VERB
cusj-12940	14	3	the	the	DET
cusj-12940	14	4	expression	expression	NOUN
cusj-12940	14	5	of	of	ADP
cusj-12940	14	6	atp6v1a	atp6v1a	PROPN
cusj-12940	14	7	--	--	PUNCT
cusj-12940	14	8	the	the	DET
cusj-12940	14	9	first	first	ADJ
cusj-12940	14	10	step	step	NOUN
cusj-12940	14	11	of	of	ADP
cusj-12940	14	12	the	the	DET
cusj-12940	14	13	“	"	PUNCT
cusj-12940	14	14	cascade	cascade	NOUN
cusj-12940	14	15	effect”--aebsf	effect”--aebsf	ADV
cusj-12940	14	16	creates	create	VERB
cusj-12940	14	17	an	an	DET
cusj-12940	14	18	unfavorable	unfavorable	ADJ
cusj-12940	14	19	environment	environment	NOUN
cusj-12940	14	20	for	for	ADP
cusj-12940	14	21	protease	protease	NOUN
cusj-12940	14	22	activity	activity	NOUN
cusj-12940	14	23	.	.	PUNCT
cusj-12940	15	1	such	such	ADJ
cusj-12940	15	2	“	"	PUNCT
cusj-12940	15	3	unfavorability	unfavorability	NOUN
cusj-12940	15	4	”	"	PUNCT
cusj-12940	15	5	is	be	AUX
cusj-12940	15	6	proven	prove	VERB
cusj-12940	15	7	by	by	ADP
cusj-12940	15	8	a	a	DET
cusj-12940	15	9	decline	decline	NOUN
cusj-12940	15	10	in	in	ADP
cusj-12940	15	11	expression	expression	NOUN
cusj-12940	15	12	of	of	ADP
cusj-12940	15	13	proteases	protease	NOUN
cusj-12940	15	14	mmp9	mmp9	VERB
cusj-12940	15	15	and	and	CCONJ
cusj-12940	15	16	elane	elane	NOUN
cusj-12940	15	17	upon	upon	SCONJ
cusj-12940	15	18	gbm	gbm	NOUN
cusj-12940	15	19	treatment	treatment	NOUN
cusj-12940	15	20	with	with	ADP
cusj-12940	15	21	aebsf	aebsf	ADJ
cusj-12940	15	22	.	.	PUNCT
cusj-12940	16	1	increasingly	increasingly	ADV
cusj-12940	16	2	higher	high	ADJ
cusj-12940	16	3	concentrations	concentration	NOUN
cusj-12940	16	4	of	of	ADP
cusj-12940	16	5	aebsf	aebsf	ADV
cusj-12940	16	6	are	be	AUX
cusj-12940	16	7	shown	show	VERB
cusj-12940	16	8	to	to	PART
cusj-12940	16	9	decrease	decrease	VERB
cusj-12940	16	10	the	the	DET
cusj-12940	16	11	percentage	percentage	NOUN
cusj-12940	16	12	of	of	ADP
cusj-12940	16	13	cell	cell	NOUN
cusj-12940	16	14	viability	viability	NOUN
cusj-12940	16	15	,	,	PUNCT
cusj-12940	16	16	proliferation	proliferation	NOUN
cusj-12940	16	17	,	,	PUNCT
cusj-12940	16	18	and	and	CCONJ
cusj-12940	16	19	metastasis	metastasis	NOUN
cusj-12940	16	20	.	.	PUNCT
cusj-12940	17	1	this	this	PRON
cusj-12940	17	2	is	be	AUX
cusj-12940	17	3	explained	explain	VERB
cusj-12940	17	4	through	through	ADP
cusj-12940	17	5	biological	biological	ADJ
cusj-12940	17	6	process	process	NOUN
cusj-12940	17	7	enrichment	enrichment	NOUN
cusj-12940	17	8	analyses	analysis	NOUN
cusj-12940	17	9	,	,	PUNCT
cusj-12940	17	10	which	which	PRON
cusj-12940	17	11	indicate	indicate	VERB
cusj-12940	17	12	that	that	DET
cusj-12940	17	13	mmp9	mmp9	NOUN
cusj-12940	17	14	and	and	CCONJ
cusj-12940	17	15	elane	elane	NOUN
cusj-12940	17	16	play	play	VERB
cusj-12940	17	17	a	a	DET
cusj-12940	17	18	role	role	NOUN
cusj-12940	17	19	in	in	ADP
cusj-12940	17	20	the	the	DET
cusj-12940	17	21	disassembly	disassembly	NOUN
cusj-12940	17	22	of	of	ADP
cusj-12940	17	23	the	the	DET
cusj-12940	17	24	extracellular	extracellular	ADJ
cusj-12940	17	25	protein	protein	NOUN
cusj-12940	17	26	network	network	NOUN
cusj-12940	17	27	.	.	PUNCT
cusj-12940	18	1	this	this	DET
cusj-12940	18	2	disassembly	disassembly	NOUN
cusj-12940	18	3	of	of	ADP
cusj-12940	18	4	the	the	DET
cusj-12940	18	5	extracellular	extracellular	ADJ
cusj-12940	18	6	environment	environment	NOUN
cusj-12940	18	7	enables	enable	VERB
cusj-12940	18	8	tumorigenic	tumorigenic	ADJ
cusj-12940	18	9	spread	spread	NOUN
cusj-12940	18	10	and	and	CCONJ
cusj-12940	18	11	viability	viability	NOUN
cusj-12940	18	12	.	.	PUNCT
cusj-12940	19	1	the	the	DET
cusj-12940	19	2	results	result	NOUN
cusj-12940	19	3	of	of	ADP
cusj-12940	19	4	the	the	DET
cusj-12940	19	5	viability	viability	NOUN
cusj-12940	19	6	and	and	CCONJ
cusj-12940	19	7	proliferation	proliferation	NOUN
cusj-12940	19	8	assays	assay	NOUN
cusj-12940	19	9	,	,	PUNCT
cusj-12940	19	10	in	in	ADP
cusj-12940	19	11	combination	combination	NOUN
cusj-12940	19	12	with	with	ADP
cusj-12940	19	13	those	those	PRON
cusj-12940	19	14	of	of	ADP
cusj-12940	19	15	the	the	DET
cusj-12940	19	16	indirect	indirect	ADJ
cusj-12940	19	17	elisas	elisas	NOUN
cusj-12940	19	18	,	,	PUNCT
cusj-12940	19	19	enrichment	enrichment	NOUN
cusj-12940	19	20	analyses	analysis	NOUN
cusj-12940	19	21	,	,	PUNCT
cusj-12940	19	22	and	and	CCONJ
cusj-12940	19	23	scratch	scratch	NOUN
cusj-12940	19	24	assays	assay	NOUN
cusj-12940	19	25	,	,	PUNCT
cusj-12940	19	26	underscore	underscore	VERB
cusj-12940	19	27	an	an	DET
cusj-12940	19	28	intricate	intricate	ADJ
cusj-12940	19	29	and	and	CCONJ
cusj-12940	19	30	profound	profound	ADJ
cusj-12940	19	31	sequence	sequence	NOUN
cusj-12940	19	32	of	of	ADP
cusj-12940	19	33	events	event	NOUN
cusj-12940	19	34	that	that	PRON
cusj-12940	19	35	constitute	constitute	VERB
cusj-12940	19	36	the	the	DET
cusj-12940	19	37	“	"	PUNCT
cusj-12940	19	38	cascade	cascade	NOUN
cusj-12940	19	39	effect	effect	NOUN
cusj-12940	19	40	”	"	PUNCT
cusj-12940	19	41	.	.	PUNCT
cusj-12940	20	1	17	17	NUM
cusj-12940	20	2	endosomes	endosome	NOUN
cusj-12940	20	3	,	,	PUNCT
cusj-12940	20	4	secretory	secretory	ADJ
cusj-12940	20	5	vesicles	vesicle	NOUN
cusj-12940	20	6	,	,	PUNCT
cusj-12940	20	7	clathrin	clathrin	NOUN
cusj-12940	20	8	-	-	PUNCT
cusj-12940	20	9	coated	coat	VERB
cusj-12940	20	10	vesicles	vesicle	NOUN
cusj-12940	20	11	,	,	PUNCT
cusj-12940	20	12	and	and	CCONJ
cusj-12940	20	13	the	the	DET
cusj-12940	20	14	plasma	plasma	NOUN
cusj-12940	20	15	membrane	membrane	NOUN
cusj-12940	20	16	[	[	X
cusj-12940	20	17	4	4	NUM
cusj-12940	20	18	]	]	PUNCT
cusj-12940	20	19	.	.	PUNCT
cusj-12940	21	1	consisting	consist	VERB
cusj-12940	21	2	of	of	ADP
cusj-12940	21	3	13	13	NUM
cusj-12940	21	4	subunits	subunit	NOUN
cusj-12940	21	5	in	in	ADP
cusj-12940	21	6	mammalian	mammalian	ADJ
cusj-12940	21	7	cells	cell	NOUN
cusj-12940	21	8	,	,	PUNCT
cusj-12940	21	9	the	the	DET
cusj-12940	21	10	primary	primary	ADJ
cusj-12940	21	11	function	function	NOUN
cusj-12940	21	12	of	of	ADP
cusj-12940	21	13	these	these	DET
cusj-12940	21	14	proton	proton	NOUN
cusj-12940	21	15	pumps	pump	NOUN
cusj-12940	21	16	is	be	AUX
cusj-12940	21	17	to	to	PART
cusj-12940	21	18	regulate	regulate	VERB
cusj-12940	21	19	both	both	CCONJ
cusj-12940	21	20	intracellular	intracellular	ADJ
cusj-12940	21	21	and	and	CCONJ
cusj-12940	21	22	extracellular	extracellular	ADJ
cusj-12940	21	23	acidification	acidification	NOUN
cusj-12940	21	24	[	[	X
cusj-12940	21	25	5	5	NUM
cusj-12940	21	26	]	]	PUNCT
cusj-12940	21	27	.	.	PUNCT
cusj-12940	22	1	v	v	X
cusj-12940	22	2	-	-	PUNCT
cusj-12940	22	3	atpases	atpase	NOUN
cusj-12940	22	4	comprise	comprise	VERB
cusj-12940	22	5	two	two	NUM
cusj-12940	22	6	domains	domain	NOUN
cusj-12940	22	7	:	:	PUNCT
cusj-12940	22	8	the	the	DET
cusj-12940	22	9	v0	v0	NOUN
cusj-12940	22	10	and	and	CCONJ
cusj-12940	22	11	v1	v1	NOUN
cusj-12940	22	12	domains	domain	NOUN
cusj-12940	22	13	.	.	PUNCT
cusj-12940	23	1	the	the	DET
cusj-12940	23	2	peripheral	peripheral	ADJ
cusj-12940	23	3	v1	v1	NOUN
cusj-12940	23	4	domain	domain	NOUN
cusj-12940	23	5	consists	consist	VERB
cusj-12940	23	6	of	of	ADP
cusj-12940	23	7	eight	eight	NUM
cusj-12940	23	8	subunits	subunit	NOUN
cusj-12940	23	9	(	(	PUNCT
cusj-12940	23	10	a	a	DET
cusj-12940	23	11	–	–	PUNCT
cusj-12940	23	12	h	h	NOUN
cusj-12940	23	13	)	)	PUNCT
cusj-12940	23	14	,	,	PUNCT
cusj-12940	23	15	all	all	PRON
cusj-12940	23	16	of	of	ADP
cusj-12940	23	17	which	which	PRON
cusj-12940	23	18	assist	assist	VERB
cusj-12940	23	19	in	in	ADP
cusj-12940	23	20	atp	atp	NOUN
cusj-12940	23	21	hydrolysis	hydrolysis	NOUN
cusj-12940	23	22	.	.	PUNCT
cusj-12940	24	1	the	the	DET
cusj-12940	24	2	membrane	membrane	NOUN
cusj-12940	24	3	-	-	PUNCT
cusj-12940	24	4	embedded	embed	VERB
cusj-12940	24	5	v0	v0	NOUN
cusj-12940	24	6	domain	domain	NOUN
cusj-12940	24	7	--	--	PUNCT
cusj-12940	24	8	consisting	consist	VERB
cusj-12940	24	9	of	of	ADP
cusj-12940	24	10	subunits	subunit	NOUN
cusj-12940	24	11	a	a	PRON
cusj-12940	24	12	,	,	PUNCT
cusj-12940	24	13	c	c	NOUN
cusj-12940	24	14	,	,	PUNCT
cusj-12940	24	15	c″	c″	NOUN
cusj-12940	24	16	,	,	PUNCT
cusj-12940	24	17	d	d	NOUN
cusj-12940	24	18	,	,	PUNCT
cusj-12940	24	19	and	and	CCONJ
cusj-12940	24	20	e	e	X
cusj-12940	24	21	--	--	PUNCT
cusj-12940	24	22	is	be	AUX
cusj-12940	24	23	responsible	responsible	ADJ
cusj-12940	24	24	for	for	ADP
cusj-12940	24	25	proton	proton	NOUN
cusj-12940	24	26	translocation	translocation	NOUN
cusj-12940	24	27	[	[	X
cusj-12940	24	28	6	6	NUM
cusj-12940	24	29	]	]	PUNCT
cusj-12940	24	30	.	.	PUNCT
cusj-12940	25	1	in	in	ADP
cusj-12940	25	2	this	this	DET
cusj-12940	25	3	study	study	NOUN
cusj-12940	25	4	,	,	PUNCT
cusj-12940	25	5	subunit	subunit	NOUN
cusj-12940	25	6	a	a	PRON
cusj-12940	25	7	of	of	ADP
cusj-12940	25	8	the	the	DET
cusj-12940	25	9	v1	v1	NOUN
cusj-12940	25	10	domain	domain	NOUN
cusj-12940	25	11	(	(	PUNCT
cusj-12940	25	12	atp6v1a	atp6v1a	NUM
cusj-12940	25	13	)	)	PUNCT
cusj-12940	25	14	is	be	AUX
cusj-12940	25	15	closely	closely	ADV
cusj-12940	25	16	examined	examine	VERB
cusj-12940	25	17	due	due	ADP
cusj-12940	25	18	to	to	ADP
cusj-12940	25	19	its	its	PRON
cusj-12940	25	20	cytoplasmic	cytoplasmic	ADJ
cusj-12940	25	21	location	location	NOUN
cusj-12940	25	22	and	and	CCONJ
cusj-12940	25	23	ubiquitous	ubiquitous	ADJ
cusj-12940	25	24	nature	nature	NOUN
cusj-12940	25	25	across	across	ADP
cusj-12940	25	26	the	the	DET
cusj-12940	25	27	body	body	NOUN
cusj-12940	25	28	[	[	X
cusj-12940	25	29	14	14	NUM
cusj-12940	25	30	,	,	PUNCT
cusj-12940	25	31	15	15	NUM
cusj-12940	25	32	]	]	PUNCT
cusj-12940	25	33	.	.	PUNCT
cusj-12940	26	1	this	this	DET
cusj-12940	26	2	study	study	NOUN
cusj-12940	26	3	explores	explore	VERB
cusj-12940	26	4	the	the	DET
cusj-12940	26	5	sequence	sequence	NOUN
cusj-12940	26	6	of	of	ADP
cusj-12940	26	7	events	event	NOUN
cusj-12940	26	8	in	in	ADP
cusj-12940	26	9	the	the	DET
cusj-12940	26	10	“	"	PUNCT
cusj-12940	26	11	cascade	cascade	NOUN
cusj-12940	26	12	effect	effect	NOUN
cusj-12940	26	13	”	"	PUNCT
cusj-12940	26	14	perpetuated	perpetuate	VERB
cusj-12940	26	15	by	by	ADP
cusj-12940	26	16	4	4	NUM
cusj-12940	26	17	-	-	PUNCT
cusj-12940	26	18	benzenesulfonyl	benzenesulfonyl	NOUN
cusj-12940	26	19	fluoride	fluoride	NOUN
cusj-12940	26	20	hydrochloride	hydrochloride	NOUN
cusj-12940	26	21	(	(	PUNCT
cusj-12940	26	22	aebsf	aebsf	ADJ
cusj-12940	26	23	)	)	PUNCT
cusj-12940	26	24	.	.	PUNCT
cusj-12940	27	1	aebsf	aebsf	ADV
cusj-12940	27	2	,	,	PUNCT
cusj-12940	27	3	also	also	ADV
cusj-12940	27	4	known	know	VERB
cusj-12940	27	5	as	as	ADP
cusj-12940	27	6	aebsf	aebsf	ADJ
cusj-12940	27	7	hydrochloride	hydrochloride	NOUN
cusj-12940	27	8	,	,	PUNCT
cusj-12940	27	9	is	be	AUX
cusj-12940	27	10	an	an	DET
cusj-12940	27	11	irreversible	irreversible	ADJ
cusj-12940	27	12	serine	serine	NOUN
cusj-12940	27	13	protease	protease	NOUN
cusj-12940	27	14	inhibitor	inhibitor	NOUN
cusj-12940	27	15	that	that	PRON
cusj-12940	27	16	has	have	AUX
cusj-12940	27	17	previously	previously	ADV
cusj-12940	27	18	been	be	AUX
cusj-12940	27	19	indicated	indicate	VERB
cusj-12940	27	20	to	to	PART
cusj-12940	27	21	inactivate	inactivate	VERB
cusj-12940	27	22	serine	serine	NOUN
cusj-12940	27	23	proteases	protease	NOUN
cusj-12940	27	24	such	such	ADJ
cusj-12940	27	25	as	as	ADP
cusj-12940	27	26	chymotrypsin	chymotrypsin	NOUN
cusj-12940	27	27	and	and	CCONJ
cusj-12940	27	28	proteinase	proteinase	NOUN
cusj-12940	27	29	k	k	PROPN
cusj-12940	28	1	[	[	X
cusj-12940	28	2	11	11	NUM
cusj-12940	28	3	]	]	PUNCT
cusj-12940	28	4	.	.	PUNCT
cusj-12940	29	1	aebsf	aebsf	PROPN
cusj-12940	29	2	has	have	AUX
cusj-12940	29	3	been	be	AUX
cusj-12940	29	4	shown	show	VERB
cusj-12940	29	5	in	in	ADP
cusj-12940	29	6	literature	literature	NOUN
cusj-12940	29	7	to	to	PART
cusj-12940	29	8	have	have	VERB
cusj-12940	29	9	a	a	DET
cusj-12940	29	10	potential	potential	ADJ
cusj-12940	29	11	regulatory	regulatory	ADJ
cusj-12940	29	12	effect	effect	NOUN
cusj-12940	29	13	on	on	ADP
cusj-12940	29	14	the	the	DET
cusj-12940	29	15	secretion	secretion	NOUN
cusj-12940	29	16	of	of	ADP
cusj-12940	29	17	antitumor	antitumor	PROPN
cusj-12940	29	18	effector	effector	NOUN
cusj-12940	29	19	molecules	molecule	NOUN
cusj-12940	29	20	in	in	ADP
cusj-12940	29	21	leukemia	leukemia	NOUN
cusj-12940	30	1	[	[	X
cusj-12940	30	2	12	12	NUM
cusj-12940	30	3	]	]	PUNCT
cusj-12940	30	4	.	.	PUNCT
cusj-12940	31	1	aebsf	aebsf	PROPN
cusj-12940	31	2	has	have	AUX
cusj-12940	31	3	also	also	ADV
cusj-12940	31	4	been	be	AUX
cusj-12940	31	5	shown	show	VERB
cusj-12940	31	6	to	to	PART
cusj-12940	31	7	reduces	reduce	VERB
cusj-12940	31	8	dengue	dengue	NOUN
cusj-12940	31	9	virus	virus	NOUN
cusj-12940	31	10	infection	infection	NOUN
cusj-12940	31	11	via	via	ADP
cusj-12940	31	12	decreased	decrease	VERB
cusj-12940	31	13	cholesterol	cholesterol	NOUN
cusj-12940	31	14	synthesis	synthesis	NOUN
cusj-12940	32	1	[	[	X
cusj-12940	32	2	13	13	NUM
cusj-12940	32	3	]	]	PUNCT
cusj-12940	32	4	.	.	PUNCT
cusj-12940	33	1	in	in	ADP
cusj-12940	33	2	this	this	DET
cusj-12940	33	3	study	study	NOUN
cusj-12940	33	4	,	,	PUNCT
cusj-12940	33	5	aebsf	aebsf	ADV
cusj-12940	33	6	was	be	AUX
cusj-12940	33	7	studied	study	VERB
cusj-12940	33	8	under	under	ADP
cusj-12940	33	9	the	the	DET
cusj-12940	33	10	context	context	NOUN
cusj-12940	33	11	of	of	ADP
cusj-12940	33	12	gb	gb	NOUN
cusj-12940	33	13	,	,	PUNCT
cusj-12940	33	14	proliferation	proliferation	NOUN
cusj-12940	33	15	and	and	CCONJ
cusj-12940	33	16	metastasis	metastasis	NOUN
cusj-12940	33	17	.	.	PUNCT
cusj-12940	34	1	the	the	DET
cusj-12940	34	2	question	question	NOUN
cusj-12940	34	3	sought	seek	VERB
cusj-12940	34	4	to	to	PART
cusj-12940	34	5	be	be	AUX
cusj-12940	34	6	answered	answer	VERB
cusj-12940	34	7	is	be	AUX
cusj-12940	34	8	,	,	PUNCT
cusj-12940	34	9	“	"	PUNCT
cusj-12940	34	10	what	what	PRON
cusj-12940	34	11	are	be	AUX
cusj-12940	34	12	the	the	DET
cusj-12940	34	13	chronological	chronological	ADJ
cusj-12940	34	14	events	event	NOUN
cusj-12940	34	15	that	that	PRON
cusj-12940	34	16	occur	occur	VERB
cusj-12940	34	17	in	in	ADP
cusj-12940	34	18	the	the	DET
cusj-12940	34	19	reduction	reduction	NOUN
cusj-12940	34	20	of	of	ADP
cusj-12940	34	21	gbm	gbm	NOUN
cusj-12940	34	22	metastasis	metastasis	NOUN
cusj-12940	34	23	perpetuated	perpetuate	VERB
cusj-12940	34	24	by	by	ADP
cusj-12940	34	25	aebsf	aebsf	ADJ
cusj-12940	34	26	?	?	PUNCT
cusj-12940	34	27	”	"	PUNCT
cusj-12940	35	1	the	the	DET
cusj-12940	35	2	findings	finding	NOUN
cusj-12940	35	3	in	in	ADP
cusj-12940	35	4	this	this	DET
cusj-12940	35	5	study	study	NOUN
cusj-12940	35	6	may	may	AUX
cusj-12940	35	7	:	:	PUNCT
cusj-12940	35	8	1	1	X
cusj-12940	35	9	)	)	PUNCT
cusj-12940	35	10	provide	provide	VERB
cusj-12940	35	11	more	more	ADJ
cusj-12940	35	12	insight	insight	NOUN
cusj-12940	35	13	into	into	ADP
cusj-12940	35	14	the	the	DET
cusj-12940	35	15	mechanics	mechanic	NOUN
cusj-12940	35	16	of	of	ADP
cusj-12940	35	17	gbm	gbm	PROPN
cusj-12940	35	18	metastasis	metastasis	NOUN
cusj-12940	35	19	,	,	PUNCT
cusj-12940	35	20	2	2	X
cusj-12940	35	21	)	)	PUNCT
cusj-12940	35	22	highlight	highlight	VERB
cusj-12940	35	23	the	the	DET
cusj-12940	35	24	role	role	NOUN
cusj-12940	35	25	of	of	ADP
cusj-12940	35	26	serine	serine	NOUN
cusj-12940	35	27	proteases	protease	NOUN
cusj-12940	35	28	in	in	ADP
cusj-12940	35	29	gbm	gbm	NOUN
cusj-12940	35	30	progression	progression	NOUN
cusj-12940	35	31	,	,	PUNCT
cusj-12940	35	32	and	and	CCONJ
cusj-12940	35	33	3	3	X
cusj-12940	35	34	)	)	PUNCT
cusj-12940	35	35	provide	provide	VERB
cusj-12940	35	36	greater	great	ADJ
cusj-12940	35	37	insight	insight	NOUN
cusj-12940	35	38	into	into	ADP
cusj-12940	35	39	such	such	ADJ
cusj-12940	35	40	proteases	protease	NOUN
cusj-12940	35	41	’	'	PUNCT
cusj-12940	35	42	mechanisms	mechanism	NOUN
cusj-12940	35	43	of	of	ADP
cusj-12940	35	44	action	action	NOUN
cusj-12940	35	45	,	,	PUNCT
cusj-12940	35	46	thereby	thereby	ADV
cusj-12940	35	47	clarifying	clarify	VERB
cusj-12940	35	48	the	the	DET
cusj-12940	35	49	link	link	NOUN
cusj-12940	35	50	between	between	ADP
cusj-12940	35	51	ecm	ecm	NOUN
cusj-12940	35	52	disassembly	disassembly	ADV
cusj-12940	35	53	and	and	CCONJ
cusj-12940	35	54	gbm	gbm	PROPN
cusj-12940	35	55	metastasis	metastasis	NOUN
cusj-12940	35	56	.	.	PUNCT
cusj-12940	36	1	methods	method	NOUN
cusj-12940	36	2	cell	cell	NOUN
cusj-12940	36	3	culture	culture	PROPN
cusj-12940	36	4	t98	t98	PROPN
cusj-12940	36	5	g	g	PROPN
cusj-12940	36	6	human	human	ADJ
cusj-12940	36	7	glioblastoma	glioblastoma	NOUN
cusj-12940	36	8	cells	cell	NOUN
cusj-12940	36	9	were	be	AUX
cusj-12940	36	10	obtained	obtain	VERB
cusj-12940	36	11	from	from	ADP
cusj-12940	36	12	the	the	DET
cusj-12940	36	13	american	american	ADJ
cusj-12940	36	14	type	type	NOUN
cusj-12940	36	15	culture	culture	NOUN
cusj-12940	36	16	collection	collection	NOUN
cusj-12940	36	17	(	(	PUNCT
cusj-12940	36	18	crl-1690	crl-1690	NOUN
cusj-12940	36	19	;	;	PUNCT
cusj-12940	36	20	atcc	atcc	PROPN
cusj-12940	36	21	,	,	PUNCT
cusj-12940	36	22	manassas	manassas	PROPN
cusj-12940	36	23	,	,	PUNCT
cusj-12940	36	24	va	va	PROPN
cusj-12940	36	25	,	,	PUNCT
cusj-12940	36	26	usa	usa	PROPN
cusj-12940	36	27	)	)	PUNCT
cusj-12940	36	28	.	.	PUNCT
cusj-12940	37	1	cells	cell	NOUN
cusj-12940	37	2	were	be	AUX
cusj-12940	37	3	grown	grow	VERB
cusj-12940	37	4	in	in	ADP
cusj-12940	37	5	dulbecco	dulbecco	NOUN
cusj-12940	37	6	's	's	PART
cusj-12940	37	7	modified	modify	VERB
cusj-12940	37	8	eagle	eagle	PROPN
cusj-12940	37	9	medium	medium	NOUN
cusj-12940	37	10	(	(	PUNCT
cusj-12940	37	11	dmem	dmem	ADJ
cusj-12940	37	12	)	)	PUNCT
cusj-12940	37	13	supplemented	supplement	VERB
cusj-12940	37	14	with	with	ADP
cusj-12940	37	15	1	1	NUM
cusj-12940	37	16	%	%	NOUN
cusj-12940	37	17	5000	5000	NUM
cusj-12940	37	18	u	u	NOUN
cusj-12940	37	19	/	/	SYM
cusj-12940	37	20	ml	ml	ADP
cusj-12940	37	21	penicillin	penicillin	NOUN
cusj-12940	37	22	-	-	PUNCT
cusj-12940	37	23	streptomycin	streptomycin	PROPN
cusj-12940	37	24	(	(	PUNCT
cusj-12940	37	25	thermofisher	thermofisher	PROPN
cusj-12940	37	26	,	,	PUNCT
cusj-12940	37	27	waltham	waltham	PROPN
cusj-12940	37	28	,	,	PUNCT
cusj-12940	37	29	ma	ma	PROPN
cusj-12940	37	30	,	,	PUNCT
cusj-12940	37	31	usa	usa	PROPN
cusj-12940	37	32	)	)	PUNCT
cusj-12940	37	33	and	and	CCONJ
cusj-12940	37	34	10	10	NUM
cusj-12940	37	35	%	%	NOUN
cusj-12940	37	36	fetal	fetal	ADJ
cusj-12940	37	37	bovine	bovine	NOUN
cusj-12940	37	38	serum	serum	NOUN
cusj-12940	37	39	(	(	PUNCT
cusj-12940	37	40	fbs	fbs	PROPN
cusj-12940	37	41	)	)	PUNCT
cusj-12940	37	42	(	(	PUNCT
cusj-12940	37	43	gibco	gibco	NOUN
cusj-12940	37	44	,	,	PUNCT
cusj-12940	37	45	waltham	waltham	PROPN
cusj-12940	37	46	,	,	PUNCT
cusj-12940	37	47	ma	ma	PROPN
cusj-12940	37	48	,	,	PUNCT
cusj-12940	37	49	usa	usa	PROPN
cusj-12940	37	50	)	)	PUNCT
cusj-12940	37	51	.	.	PUNCT
cusj-12940	38	1	cells	cell	NOUN
cusj-12940	38	2	were	be	AUX
cusj-12940	38	3	incubated	incubate	VERB
cusj-12940	38	4	at	at	ADP
cusj-12940	38	5	37	37	NUM
cusj-12940	38	6	°	°	NOUN
cusj-12940	38	7	c	c	NOUN
cusj-12940	38	8	with	with	ADP
cusj-12940	38	9	5	5	NUM
cusj-12940	38	10	%	%	NOUN
cusj-12940	38	11	co2	co2	NOUN
cusj-12940	38	12	and	and	CCONJ
cusj-12940	38	13	100	100	NUM
cusj-12940	38	14	%	%	NOUN
cusj-12940	39	1	humidity	humidity	NOUN
cusj-12940	40	1	.	.	PUNCT
cusj-12940	41	1	cell	cell	NOUN
cusj-12940	41	2	culture	culture	NOUN
cusj-12940	41	3	images	image	NOUN
cusj-12940	41	4	were	be	AUX
cusj-12940	41	5	taken	take	VERB
cusj-12940	41	6	with	with	ADP
cusj-12940	41	7	a	a	DET
cusj-12940	41	8	nikon	nikon	ADJ
cusj-12940	41	9	eclipse	eclipse	NOUN
cusj-12940	41	10	ts100	ts100	PROPN
cusj-12940	41	11	light	light	ADJ
cusj-12940	41	12	microscope	microscope	NOUN
cusj-12940	41	13	at	at	ADP
cusj-12940	41	14	100x	100x	NUM
cusj-12940	41	15	magnification	magnification	NOUN
cusj-12940	41	16	.	.	PUNCT
cusj-12940	42	1	figure	figure	NOUN
cusj-12940	42	2	1	1	NUM
cusj-12940	42	3	.	.	PUNCT
cusj-12940	42	4	created	create	VERB
cusj-12940	42	5	by	by	ADP
cusj-12940	42	6	author	author	PROPN
cusj-12940	42	7	columbia	columbia	PROPN
cusj-12940	42	8	undergraduate	undergraduate	PROPN
cusj-12940	42	9	science	science	PROPN
cusj-12940	42	10	journal	journal	PROPN
cusj-12940	42	11	vol	vol	NOUN
cusj-12940	42	12	.	.	PROPN
cusj-12940	43	1	16	16	NUM
cusj-12940	43	2	,	,	PUNCT
cusj-12940	43	3	2022	2022	NUM
cusj-12940	43	4	18	18	NUM
cusj-12940	43	5	reagent	reagent	ADJ
cusj-12940	43	6	preparation	preparation	NOUN
cusj-12940	43	7	aebsf	aebsf	ADV
cusj-12940	43	8	(	(	PUNCT
cusj-12940	43	9	solubility	solubility	NOUN
cusj-12940	43	10	50mg	50mg	NOUN
cusj-12940	43	11	/	/	SYM
cusj-12940	43	12	ml	ml	X
cusj-12940	43	13	h2o	h2o	PROPN
cusj-12940	43	14	,	,	PUNCT
cusj-12940	43	15	molar	molar	ADJ
cusj-12940	43	16	mass	mass	NOUN
cusj-12940	43	17	:	:	PUNCT
cusj-12940	43	18	239.69	239.69	NUM
cusj-12940	43	19	g	g	NOUN
cusj-12940	43	20	/	/	SYM
cusj-12940	43	21	mol	mol	NOUN
cusj-12940	43	22	)	)	PUNCT
cusj-12940	43	23	was	be	AUX
cusj-12940	43	24	dissolved	dissolve	VERB
cusj-12940	43	25	in	in	ADP
cusj-12940	43	26	h2o	h2o	PROPN
cusj-12940	43	27	.	.	PUNCT
cusj-12940	44	1	treatment	treatment	NOUN
cusj-12940	44	2	of	of	ADP
cusj-12940	44	3	cells	cell	NOUN
cusj-12940	44	4	with	with	ADP
cusj-12940	44	5	aebsf	aebsf	ADJ
cusj-12940	44	6	cells	cell	NOUN
cusj-12940	44	7	were	be	AUX
cusj-12940	44	8	seeded	seed	VERB
cusj-12940	44	9	at	at	ADP
cusj-12940	44	10	~10	~10	NOUN
cusj-12940	44	11	^	^	SYM
cusj-12940	44	12	6	6	NUM
cusj-12940	44	13	cells	cell	NOUN
cusj-12940	44	14	in	in	ADP
cusj-12940	44	15	t25	t25	ADJ
cusj-12940	44	16	flasks	flask	NOUN
cusj-12940	44	17	for	for	ADP
cusj-12940	44	18	24	24	NUM
cusj-12940	44	19	hours	hour	NOUN
cusj-12940	44	20	(	(	PUNCT
cusj-12940	44	21	incubated	incubate	VERB
cusj-12940	44	22	at	at	ADP
cusj-12940	44	23	37	37	NUM
cusj-12940	44	24	°	°	ADP
cusj-12940	44	25	c	c	NOUN
cusj-12940	44	26	with	with	ADP
cusj-12940	44	27	5	5	NUM
cusj-12940	44	28	%	%	NOUN
cusj-12940	44	29	co2	co2	NOUN
cusj-12940	44	30	and	and	CCONJ
cusj-12940	44	31	100	100	NUM
cusj-12940	44	32	%	%	NOUN
cusj-12940	44	33	humidity	humidity	NOUN
cusj-12940	44	34	)	)	PUNCT
cusj-12940	44	35	.	.	PUNCT
cusj-12940	45	1	cells	cell	NOUN
cusj-12940	45	2	were	be	AUX
cusj-12940	45	3	subsequently	subsequently	ADV
cusj-12940	45	4	treated	treat	VERB
cusj-12940	45	5	with	with	ADP
cusj-12940	45	6	the	the	DET
cusj-12940	45	7	appropriate	appropriate	ADJ
cusj-12940	45	8	aebsf	aebsf	NOUN
cusj-12940	45	9	concentrations--125	concentrations--125	NOUN
cusj-12940	45	10	µm	µm	NOUN
cusj-12940	45	11	,	,	PUNCT
cusj-12940	45	12	500	500	NUM
cusj-12940	45	13	µm	µm	NOUN
cusj-12940	45	14	,	,	PUNCT
cusj-12940	45	15	or	or	CCONJ
cusj-12940	45	16	2000µm	2000µm	NOUN
cusj-12940	45	17	--	--	PUNCT
cusj-12940	45	18	for	for	ADP
cusj-12940	45	19	48	48	NUM
cusj-12940	45	20	hours	hour	NOUN
cusj-12940	45	21	.	.	PUNCT
cusj-12940	46	1	preparation	preparation	NOUN
cusj-12940	46	2	of	of	ADP
cusj-12940	46	3	lysates	lysate	NOUN
cusj-12940	46	4	for	for	ADP
cusj-12940	46	5	enzyme	enzyme	NOUN
cusj-12940	46	6	-	-	PUNCT
cusj-12940	46	7	linked	link	VERB
cusj-12940	46	8	immunosorbent	immunosorbent	NOUN
cusj-12940	46	9	assay	assay	PROPN
cusj-12940	46	10	(	(	PUNCT
cusj-12940	46	11	elisa	elisa	NOUN
cusj-12940	46	12	)	)	PUNCT
cusj-12940	46	13	phosphate	phosphate	ADJ
cusj-12940	46	14	buffered	buffer	VERB
cusj-12940	46	15	saline	saline	NOUN
cusj-12940	46	16	(	(	PUNCT
cusj-12940	46	17	pbs	pbs	PROPN
cusj-12940	46	18	)	)	PUNCT
cusj-12940	46	19	(	(	PUNCT
cusj-12940	46	20	thermofisher	thermofisher	PROPN
cusj-12940	46	21	,	,	PUNCT
cusj-12940	46	22	waltham	waltham	PROPN
cusj-12940	46	23	,	,	PUNCT
cusj-12940	46	24	ma	ma	PROPN
cusj-12940	46	25	,	,	PUNCT
cusj-12940	46	26	usa	usa	PROPN
cusj-12940	46	27	)	)	PUNCT
cusj-12940	46	28	,	,	PUNCT
cusj-12940	46	29	1x	1x	NUM
cusj-12940	46	30	cell	cell	NOUN
cusj-12940	46	31	lysis	lysis	NOUN
cusj-12940	46	32	buffer	buffer	NOUN
cusj-12940	46	33	(	(	PUNCT
cusj-12940	46	34	cell	cell	NOUN
cusj-12940	46	35	signaling	signal	VERB
cusj-12940	46	36	technology	technology	NOUN
cusj-12940	46	37	,	,	PUNCT
cusj-12940	46	38	danvers	danver	NOUN
cusj-12940	46	39	,	,	PUNCT
cusj-12940	46	40	ma	ma	PROPN
cusj-12940	46	41	,	,	PUNCT
cusj-12940	46	42	usa	usa	PROPN
cusj-12940	46	43	)	)	PUNCT
cusj-12940	46	44	,	,	PUNCT
cusj-12940	46	45	and	and	CCONJ
cusj-12940	46	46	protease	protease	NOUN
cusj-12940	46	47	inhibitor	inhibitor	NOUN
cusj-12940	46	48	cocktail	cocktail	NOUN
cusj-12940	46	49	(	(	PUNCT
cusj-12940	46	50	sigma	sigma	NOUN
cusj-12940	46	51	-	-	PUNCT
cusj-12940	46	52	aldrich	aldrich	PROPN
cusj-12940	46	53	,	,	PUNCT
cusj-12940	46	54	st	st	PROPN
cusj-12940	46	55	.	.	PROPN
cusj-12940	46	56	louis	louis	PROPN
cusj-12940	46	57	,	,	PUNCT
cusj-12940	46	58	mo	mo	PROPN
cusj-12940	46	59	,	,	PUNCT
cusj-12940	46	60	usa	usa	PROPN
cusj-12940	46	61	)	)	PUNCT
cusj-12940	46	62	were	be	AUX
cusj-12940	46	63	used	use	VERB
cusj-12940	46	64	to	to	PART
cusj-12940	46	65	lyse	lyse	VERB
cusj-12940	46	66	10	10	NUM
cusj-12940	46	67	^	^	SYM
cusj-12940	46	68	6	6	NUM
cusj-12940	46	69	cells	cell	NOUN
cusj-12940	46	70	/	/	SYM
cusj-12940	46	71	ml	ml	NOUN
cusj-12940	46	72	from	from	ADP
cusj-12940	46	73	each	each	DET
cusj-12940	46	74	treatment	treatment	NOUN
cusj-12940	46	75	group	group	NOUN
cusj-12940	46	76	.	.	PUNCT
cusj-12940	47	1	cells	cell	NOUN
cusj-12940	47	2	were	be	AUX
cusj-12940	47	3	incubated	incubate	VERB
cusj-12940	47	4	at	at	ADP
cusj-12940	47	5	37	37	NUM
cusj-12940	47	6	°	°	ADP
cusj-12940	47	7	c	c	NOUN
cusj-12940	47	8	with	with	ADP
cusj-12940	47	9	5	5	NUM
cusj-12940	47	10	%	%	NOUN
cusj-12940	47	11	co2	co2	NOUN
cusj-12940	47	12	and	and	CCONJ
cusj-12940	47	13	100	100	NUM
cusj-12940	47	14	%	%	NOUN
cusj-12940	47	15	humidity	humidity	NOUN
cusj-12940	47	16	with	with	ADP
cusj-12940	47	17	trypsin	trypsin	NOUN
cusj-12940	47	18	for	for	ADP
cusj-12940	47	19	3	3	NUM
cusj-12940	47	20	minutes	minute	NOUN
cusj-12940	47	21	until	until	ADP
cusj-12940	47	22	detachment	detachment	NOUN
cusj-12940	47	23	.	.	PUNCT
cusj-12940	48	1	cells	cell	NOUN
cusj-12940	48	2	were	be	AUX
cusj-12940	48	3	subsequently	subsequently	ADV
cusj-12940	48	4	neutralized	neutralize	VERB
cusj-12940	48	5	with	with	ADP
cusj-12940	48	6	dmem	dmem	VERB
cusj-12940	48	7	and	and	CCONJ
cusj-12940	48	8	transferred	transfer	VERB
cusj-12940	48	9	to	to	ADP
cusj-12940	48	10	15ml	15ml	ADJ
cusj-12940	48	11	centrifuge	centrifuge	NOUN
cusj-12940	48	12	tubes	tube	NOUN
cusj-12940	48	13	.	.	PUNCT
cusj-12940	49	1	tubes	tube	NOUN
cusj-12940	49	2	were	be	AUX
cusj-12940	49	3	gently	gently	ADV
cusj-12940	49	4	inverted	inverted	ADJ
cusj-12940	49	5	and	and	CCONJ
cusj-12940	49	6	cells	cell	NOUN
cusj-12940	49	7	were	be	AUX
cusj-12940	49	8	counted	count	VERB
cusj-12940	49	9	using	use	VERB
cusj-12940	49	10	vicell	vicell	PROPN
cusj-12940	49	11	xr	xr	PROPN
cusj-12940	50	1	(	(	PUNCT
cusj-12940	50	2	beckman	beckman	PROPN
cusj-12940	50	3	coulter	coulter	PROPN
cusj-12940	50	4	,	,	PUNCT
cusj-12940	50	5	indianapolis	indianapolis	PROPN
cusj-12940	50	6	,	,	PUNCT
cusj-12940	50	7	in	in	ADP
cusj-12940	50	8	,	,	PUNCT
cusj-12940	50	9	usa	usa	PROPN
cusj-12940	50	10	)	)	PUNCT
cusj-12940	50	11	.	.	PUNCT
cusj-12940	51	1	tubes	tube	NOUN
cusj-12940	51	2	were	be	AUX
cusj-12940	51	3	subsequently	subsequently	ADV
cusj-12940	51	4	centrifuged	centrifuge	VERB
cusj-12940	51	5	at	at	ADP
cusj-12940	51	6	1000	1000	NUM
cusj-12940	51	7	rpm	rpm	NOUN
cusj-12940	51	8	for	for	ADP
cusj-12940	51	9	7	7	NUM
cusj-12940	51	10	minutes	minute	NOUN
cusj-12940	51	11	at	at	ADP
cusj-12940	51	12	room	room	NOUN
cusj-12940	51	13	temperature	temperature	NOUN
cusj-12940	51	14	,	,	PUNCT
cusj-12940	51	15	after	after	ADP
cusj-12940	51	16	which	which	PRON
cusj-12940	51	17	the	the	DET
cusj-12940	51	18	pellets	pellet	NOUN
cusj-12940	51	19	were	be	AUX
cusj-12940	51	20	poured	pour	VERB
cusj-12940	51	21	off	off	ADP
cusj-12940	51	22	and	and	CCONJ
cusj-12940	51	23	the	the	DET
cusj-12940	51	24	pellet	pellet	NOUN
cusj-12940	51	25	was	be	AUX
cusj-12940	51	26	broken	break	VERB
cusj-12940	51	27	.	.	PUNCT
cusj-12940	52	1	chilled	chill	VERB
cusj-12940	52	2	pbs	pbs	PROPN
cusj-12940	52	3	was	be	AUX
cusj-12940	52	4	added	add	VERB
cusj-12940	52	5	to	to	ADP
cusj-12940	52	6	the	the	DET
cusj-12940	52	7	tubes	tube	NOUN
cusj-12940	52	8	,	,	PUNCT
cusj-12940	52	9	which	which	PRON
cusj-12940	52	10	were	be	AUX
cusj-12940	52	11	subsequently	subsequently	ADV
cusj-12940	52	12	re	re	VERB
cusj-12940	52	13	-	-	VERB
cusj-12940	52	14	centrifuged	centrifuged	ADJ
cusj-12940	52	15	at	at	ADP
cusj-12940	52	16	1000	1000	NUM
cusj-12940	52	17	rpm	rpm	NOUN
cusj-12940	52	18	for	for	ADP
cusj-12940	52	19	7	7	NUM
cusj-12940	52	20	minutes	minute	NOUN
cusj-12940	52	21	at	at	ADP
cusj-12940	52	22	25	25	NUM
cusj-12940	52	23	°	°	NOUN
cusj-12940	52	24	c	c	NOUN
cusj-12940	52	25	.	.	PUNCT
cusj-12940	53	1	the	the	DET
cusj-12940	53	2	residual	residual	ADJ
cusj-12940	53	3	supernatant	supernatant	NOUN
cusj-12940	53	4	was	be	AUX
cusj-12940	53	5	poured	pour	VERB
cusj-12940	53	6	out	out	ADP
cusj-12940	53	7	and	and	CCONJ
cusj-12940	53	8	the	the	DET
cusj-12940	53	9	pellet	pellet	NOUN
cusj-12940	53	10	was	be	AUX
cusj-12940	53	11	broken	break	VERB
cusj-12940	53	12	up	up	ADP
cusj-12940	53	13	.	.	PUNCT
cusj-12940	54	1	the	the	DET
cusj-12940	54	2	appropriate	appropriate	ADJ
cusj-12940	54	3	volume	volume	NOUN
cusj-12940	54	4	of	of	ADP
cusj-12940	54	5	lysis	lysis	NOUN
cusj-12940	54	6	buffer	buffer	NOUN
cusj-12940	54	7	,	,	PUNCT
cusj-12940	54	8	calculated	calculate	VERB
cusj-12940	54	9	using	use	VERB
cusj-12940	54	10	the	the	DET
cusj-12940	54	11	following	follow	VERB
cusj-12940	54	12	equation	equation	NOUN
cusj-12940	54	13	,	,	PUNCT
cusj-12940	54	14	was	be	AUX
cusj-12940	54	15	added	add	VERB
cusj-12940	54	16	to	to	ADP
cusj-12940	54	17	each	each	DET
cusj-12940	54	18	tube	tube	NOUN
cusj-12940	54	19	and	and	CCONJ
cusj-12940	54	20	incubated	incubate	VERB
cusj-12940	54	21	on	on	ADP
cusj-12940	54	22	ice	ice	NOUN
cusj-12940	54	23	for	for	ADP
cusj-12940	54	24	10	10	NUM
cusj-12940	54	25	minutes	minute	NOUN
cusj-12940	54	26	:	:	PUNCT
cusj-12940	55	1	[	[	X
cusj-12940	55	2	viable	viable	ADJ
cusj-12940	55	3	cell	cell	NOUN
cusj-12940	55	4	count	count	NOUN
cusj-12940	55	5	(	(	PUNCT
cusj-12940	55	6	cells	cell	NOUN
cusj-12940	55	7	/	/	SYM
cusj-12940	55	8	ml	ml	NOUN
cusj-12940	55	9	)	)	PUNCT
cusj-12940	55	10	×	×	NOUN
cusj-12940	55	11	volume	volume	NOUN
cusj-12940	55	12	of	of	ADP
cusj-12940	55	13	cell	cell	NOUN
cusj-12940	55	14	suspension	suspension	NOUN
cusj-12940	55	15	prior	prior	ADV
cusj-12940	55	16	to	to	ADP
cusj-12940	55	17	first	first	ADJ
cusj-12940	55	18	round	round	NOUN
cusj-12940	55	19	of	of	ADP
cusj-12940	55	20	centrifugation	centrifugation	NOUN
cusj-12940	55	21	(	(	PUNCT
cusj-12940	55	22	ml	ml	NOUN
cusj-12940	55	23	)	)	PUNCT
cusj-12940	55	24	]	]	PUNCT
cusj-12940	56	1	÷	÷	NUM
cusj-12940	56	2	106	106	NUM
cusj-12940	56	3	cells	cell	NOUN
cusj-12940	56	4	/	/	SYM
cusj-12940	56	5	ml	ml	NOUN
cusj-12940	56	6	lysates	lysate	NOUN
cusj-12940	56	7	from	from	ADP
cusj-12940	56	8	the	the	DET
cusj-12940	56	9	tubes	tube	NOUN
cusj-12940	56	10	were	be	AUX
cusj-12940	56	11	subsequently	subsequently	ADV
cusj-12940	56	12	transferred	transfer	VERB
cusj-12940	56	13	to	to	ADP
cusj-12940	56	14	chilled	chill	VERB
cusj-12940	56	15	eppendorf	eppendorf	PROPN
cusj-12940	56	16	tubes	tube	NOUN
cusj-12940	56	17	.	.	PUNCT
cusj-12940	57	1	the	the	DET
cusj-12940	57	2	tubes	tube	NOUN
cusj-12940	57	3	were	be	AUX
cusj-12940	57	4	micro	micro	ADJ
cusj-12940	57	5	-	-	VERB
cusj-12940	57	6	centrifuged	centrifuged	ADJ
cusj-12940	57	7	at	at	ADP
cusj-12940	57	8	13000	13000	NUM
cusj-12940	57	9	rpm	rpm	NOUN
cusj-12940	57	10	for	for	ADP
cusj-12940	57	11	15	15	NUM
cusj-12940	57	12	minutes	minute	NOUN
cusj-12940	57	13	at	at	ADP
cusj-12940	57	14	4	4	NUM
cusj-12940	57	15	°	°	NOUN
cusj-12940	57	16	c	c	NOUN
cusj-12940	57	17	.	.	PUNCT
cusj-12940	58	1	the	the	DET
cusj-12940	58	2	supernatants	supernatant	NOUN
cusj-12940	58	3	were	be	AUX
cusj-12940	58	4	stored	store	VERB
cusj-12940	58	5	at	at	ADP
cusj-12940	58	6	-80	-80	NOUN
cusj-12940	58	7	°	°	NOUN
cusj-12940	58	8	c	c	NOUN
cusj-12940	58	9	.	.	PUNCT
cusj-12940	59	1	indirect	indirect	ADJ
cusj-12940	59	2	elisa	elisa	PROPN
cusj-12940	59	3	100µl	100µl	PROPN
cusj-12940	59	4	/	/	SYM
cusj-12940	60	1	well	well	NOUN
cusj-12940	60	2	of	of	ADP
cusj-12940	60	3	lysates	lysate	NOUN
cusj-12940	60	4	were	be	AUX
cusj-12940	60	5	transferred	transfer	VERB
cusj-12940	60	6	at	at	ADP
cusj-12940	60	7	4	4	NUM
cusj-12940	60	8	replicates	replicate	NOUN
cusj-12940	60	9	per	per	ADP
cusj-12940	60	10	treatment	treatment	NOUN
cusj-12940	60	11	group	group	NOUN
cusj-12940	60	12	to	to	ADP
cusj-12940	60	13	a	a	DET
cusj-12940	60	14	96	96	NUM
cusj-12940	60	15	-	-	PUNCT
cusj-12940	60	16	well	well	NOUN
cusj-12940	60	17	plate	plate	NOUN
cusj-12940	60	18	.	.	PUNCT
cusj-12940	61	1	lysates	lysate	NOUN
cusj-12940	61	2	were	be	AUX
cusj-12940	61	3	left	leave	VERB
cusj-12940	61	4	to	to	PART
cusj-12940	61	5	incubate	incubate	VERB
cusj-12940	61	6	for	for	ADP
cusj-12940	61	7	24	24	NUM
cusj-12940	61	8	hours	hour	NOUN
cusj-12940	61	9	at	at	ADP
cusj-12940	61	10	4	4	NUM
cusj-12940	61	11	°	°	ADP
cusj-12940	61	12	c	c	NOUN
cusj-12940	61	13	and	and	CCONJ
cusj-12940	61	14	then	then	ADV
cusj-12940	61	15	removed	remove	VERB
cusj-12940	61	16	by	by	ADP
cusj-12940	61	17	blotting	blot	VERB
cusj-12940	61	18	.	.	PUNCT
cusj-12940	62	1	200µl/	200µl/	NUM
cusj-12940	62	2	well	well	NOUN
cusj-12940	62	3	of	of	ADP
cusj-12940	62	4	blocking	block	VERB
cusj-12940	62	5	buffer	buffer	NOUN
cusj-12940	62	6	(	(	PUNCT
cusj-12940	62	7	thermofisher	thermofisher	PROPN
cusj-12940	62	8	,	,	PUNCT
cusj-12940	62	9	waltham	waltham	PROPN
cusj-12940	62	10	,	,	PUNCT
cusj-12940	62	11	ma	ma	PROPN
cusj-12940	62	12	,	,	PUNCT
cusj-12940	62	13	usa	usa	PROPN
cusj-12940	62	14	)	)	PUNCT
cusj-12940	62	15	with	with	ADP
cusj-12940	62	16	1	1	NUM
cusj-12940	62	17	%	%	NOUN
cusj-12940	62	18	bovine	bovine	NOUN
cusj-12940	62	19	serum	serum	NOUN
cusj-12940	62	20	albumin	albumin	PROPN
cusj-12940	62	21	(	(	PUNCT
cusj-12940	62	22	bsa	bsa	PROPN
cusj-12940	62	23	)	)	PUNCT
cusj-12940	62	24	(	(	PUNCT
cusj-12940	62	25	seracare	seracare	NOUN
cusj-12940	62	26	,	,	PUNCT
cusj-12940	62	27	milford	milford	PROPN
cusj-12940	62	28	,	,	PUNCT
cusj-12940	62	29	ma	ma	PROPN
cusj-12940	62	30	,	,	PUNCT
cusj-12940	62	31	usa	usa	PROPN
cusj-12940	62	32	)	)	PUNCT
cusj-12940	62	33	was	be	AUX
cusj-12940	62	34	added	add	VERB
cusj-12940	62	35	and	and	CCONJ
cusj-12940	62	36	left	leave	VERB
cusj-12940	62	37	to	to	PART
cusj-12940	62	38	incubate	incubate	VERB
cusj-12940	62	39	for	for	ADP
cusj-12940	62	40	10	10	NUM
cusj-12940	62	41	minutes	minute	NOUN
cusj-12940	62	42	at	at	ADP
cusj-12940	62	43	25	25	NUM
cusj-12940	62	44	°	°	NOUN
cusj-12940	62	45	c	c	NOUN
cusj-12940	62	46	.	.	PUNCT
cusj-12940	63	1	cell	cell	NOUN
cusj-12940	63	2	proliferation	proliferation	NOUN
cusj-12940	63	3	assay	assay	NOUN
cusj-12940	63	4	cells	cell	NOUN
cusj-12940	63	5	were	be	AUX
cusj-12940	63	6	seeded	seed	VERB
cusj-12940	63	7	at	at	ADP
cusj-12940	63	8	62,500	62,500	NUM
cusj-12940	63	9	cells	cell	NOUN
cusj-12940	63	10	/	/	SYM
cusj-12940	64	1	well	well	INTJ
cusj-12940	64	2	24	24	NUM
cusj-12940	64	3	hours	hour	NOUN
cusj-12940	64	4	prior	prior	ADV
cusj-12940	64	5	to	to	ADP
cusj-12940	64	6	treatment	treatment	NOUN
cusj-12940	64	7	in	in	ADP
cusj-12940	64	8	a	a	DET
cusj-12940	64	9	6	6	NUM
cusj-12940	64	10	-	-	PUNCT
cusj-12940	64	11	well	well	NOUN
cusj-12940	64	12	plate	plate	NOUN
cusj-12940	64	13	.	.	PUNCT
cusj-12940	65	1	cells	cell	NOUN
cusj-12940	65	2	were	be	AUX
cusj-12940	65	3	subsequently	subsequently	ADV
cusj-12940	65	4	treated	treat	VERB
cusj-12940	65	5	for	for	ADP
cusj-12940	65	6	48	48	NUM
cusj-12940	65	7	hours	hour	NOUN
cusj-12940	65	8	,	,	PUNCT
cusj-12940	65	9	supernatants	supernatant	NOUN
cusj-12940	65	10	were	be	AUX
cusj-12940	65	11	collected	collect	VERB
cusj-12940	65	12	,	,	PUNCT
cusj-12940	65	13	and	and	CCONJ
cusj-12940	65	14	cell	cell	NOUN
cusj-12940	65	15	proliferation	proliferation	NOUN
cusj-12940	65	16	was	be	AUX
cusj-12940	65	17	analyzed	analyze	VERB
cusj-12940	65	18	using	use	VERB
cusj-12940	65	19	a	a	DET
cusj-12940	65	20	synergy	synergy	NOUN
cusj-12940	65	21	machine	machine	NOUN
cusj-12940	65	22	.	.	PUNCT
cusj-12940	66	1	trypan	trypan	NOUN
cusj-12940	66	2	blue	blue	ADJ
cusj-12940	66	3	exclusion	exclusion	NOUN
cusj-12940	66	4	viability	viability	NOUN
cusj-12940	66	5	assay	assay	NOUN
cusj-12940	66	6	cells	cell	NOUN
cusj-12940	66	7	were	be	AUX
cusj-12940	66	8	seeded	seed	VERB
cusj-12940	66	9	at	at	ADP
cusj-12940	66	10	~40,000	~40,000	PUNCT
cusj-12940	66	11	cells/	cells/	NUM
cusj-12940	66	12	flask	flask	NOUN
cusj-12940	66	13	24	24	NUM
cusj-12940	66	14	hours	hour	NOUN
cusj-12940	66	15	prior	prior	ADV
cusj-12940	66	16	to	to	ADP
cusj-12940	66	17	treatment	treatment	NOUN
cusj-12940	66	18	.	.	PUNCT
cusj-12940	67	1	cells	cell	NOUN
cusj-12940	67	2	were	be	AUX
cusj-12940	67	3	subsequently	subsequently	ADV
cusj-12940	67	4	treated	treat	VERB
cusj-12940	67	5	for	for	ADP
cusj-12940	67	6	48	48	NUM
cusj-12940	67	7	hours	hour	NOUN
cusj-12940	67	8	,	,	PUNCT
cusj-12940	67	9	supernatants	supernatant	NOUN
cusj-12940	67	10	were	be	AUX
cusj-12940	67	11	collected	collect	VERB
cusj-12940	67	12	,	,	PUNCT
cusj-12940	67	13	and	and	CCONJ
cusj-12940	67	14	cells	cell	NOUN
cusj-12940	67	15	were	be	AUX
cusj-12940	67	16	trypsinized	trypsinize	VERB
cusj-12940	67	17	and	and	CCONJ
cusj-12940	67	18	counted	count	VERB
cusj-12940	67	19	using	use	VERB
cusj-12940	67	20	vicell	vicell	PROPN
cusj-12940	67	21	xr	xr	PROPN
cusj-12940	67	22	(	(	PUNCT
cusj-12940	67	23	beckman	beckman	PROPN
cusj-12940	67	24	coulter	coulter	PROPN
cusj-12940	67	25	,	,	PUNCT
cusj-12940	67	26	indianapolis	indianapolis	PROPN
cusj-12940	67	27	,	,	PUNCT
cusj-12940	67	28	in	in	ADP
cusj-12940	67	29	,	,	PUNCT
cusj-12940	67	30	usa	usa	PROPN
cusj-12940	67	31	)	)	PUNCT
cusj-12940	67	32	.	.	PUNCT
cusj-12940	68	1	reverse	reverse	ADJ
cusj-12940	68	2	docking	dock	VERB
cusj-12940	68	3	reverse	reverse	NOUN
cusj-12940	68	4	docking	docking	NOUN
cusj-12940	68	5	tool	tool	NOUN
cusj-12940	68	6	chemmapper	chemmapper	NOUN
cusj-12940	68	7	was	be	AUX
cusj-12940	68	8	used	use	VERB
cusj-12940	68	9	to	to	PART
cusj-12940	68	10	predict	predict	VERB
cusj-12940	68	11	the	the	DET
cusj-12940	68	12	protein	protein	NOUN
cusj-12940	68	13	targets	target	NOUN
cusj-12940	68	14	of	of	ADP
cusj-12940	68	15	aebsf	aebsf	ADJ
cusj-12940	68	16	.	.	PUNCT
cusj-12940	69	1	the	the	DET
cusj-12940	69	2	smiles	smile	NOUN
cusj-12940	69	3	(	(	PUNCT
cusj-12940	69	4	simplified	simplify	VERB
cusj-12940	69	5	molecular	molecular	ADJ
cusj-12940	69	6	input	input	NOUN
cusj-12940	69	7	line	line	NOUN
cusj-12940	69	8	entry	entry	NOUN
cusj-12940	69	9	system	system	NOUN
cusj-12940	69	10	)	)	PUNCT
cusj-12940	69	11	notation	notation	NOUN
cusj-12940	69	12	of	of	ADP
cusj-12940	69	13	aebsf	aebsf	ADV
cusj-12940	69	14	,	,	PUNCT
cusj-12940	69	15	obtained	obtain	VERB
cusj-12940	69	16	from	from	ADP
cusj-12940	69	17	pubchem	pubchem	NOUN
cusj-12940	69	18	,	,	PUNCT
cusj-12940	69	19	was	be	AUX
cusj-12940	69	20	inputted	inputte	VERB
cusj-12940	69	21	into	into	ADP
cusj-12940	69	22	chemmapper	chemmapper	NOUN
cusj-12940	69	23	.	.	PUNCT
cusj-12940	70	1	subsequently	subsequently	ADV
cusj-12940	70	2	,	,	PUNCT
cusj-12940	70	3	the	the	DET
cusj-12940	70	4	“	"	PUNCT
cusj-12940	70	5	target	target	NOUN
cusj-12940	70	6	navigator	navigator	NOUN
cusj-12940	70	7	”	"	PUNCT
cusj-12940	70	8	service	service	NOUN
cusj-12940	70	9	was	be	AUX
cusj-12940	70	10	selected	select	VERB
cusj-12940	70	11	and	and	CCONJ
cusj-12940	70	12	the	the	DET
cusj-12940	70	13	3d	3d	PROPN
cusj-12940	70	14	similarity	similarity	NOUN
cusj-12940	70	15	method	method	NOUN
cusj-12940	70	16	shaft	shaft	NOUN
cusj-12940	70	17	was	be	AUX
cusj-12940	70	18	chosen	choose	VERB
cusj-12940	70	19	.	.	PUNCT
cusj-12940	71	1	the	the	DET
cusj-12940	71	2	default	default	NOUN
cusj-12940	71	3	similarity	similarity	NOUN
cusj-12940	71	4	threshold	threshold	NOUN
cusj-12940	71	5	of	of	ADP
cusj-12940	71	6	1.2	1.2	NUM
cusj-12940	71	7	was	be	AUX
cusj-12940	71	8	selected	select	VERB
cusj-12940	71	9	,	,	PUNCT
cusj-12940	71	10	and	and	CCONJ
cusj-12940	71	11	the	the	DET
cusj-12940	71	12	bioactivity	bioactivity	NOUN
cusj-12940	71	13	database	database	NOUN
cusj-12940	71	14	chembl	chembl	NOUN
cusj-12940	71	15	was	be	AUX
cusj-12940	71	16	then	then	ADV
cusj-12940	71	17	chosen	choose	VERB
cusj-12940	71	18	[	[	PUNCT
cusj-12940	71	19	7	7	NUM
cusj-12940	71	20	-	-	SYM
cusj-12940	71	21	9	9	NUM
cusj-12940	71	22	]	]	PUNCT
cusj-12940	71	23	.	.	PUNCT
cusj-12940	72	1	columbia	columbia	PROPN
cusj-12940	72	2	undergraduate	undergraduate	PROPN
cusj-12940	72	3	science	science	PROPN
cusj-12940	72	4	journal	journal	PROPN
cusj-12940	72	5	vol	vol	NOUN
cusj-12940	72	6	.	.	PROPN
cusj-12940	73	1	16	16	NUM
cusj-12940	73	2	,	,	PUNCT
cusj-12940	73	3	2022	2022	NUM
cusj-12940	73	4	19	19	NUM
cusj-12940	73	5	data	datum	NOUN
cusj-12940	73	6	analysis	analysis	NOUN
cusj-12940	73	7	statistical	statistical	ADJ
cusj-12940	73	8	and	and	CCONJ
cusj-12940	73	9	computational	computational	ADJ
cusj-12940	73	10	biology	biology	NOUN
cusj-12940	73	11	analyses	analysis	NOUN
cusj-12940	73	12	were	be	AUX
cusj-12940	73	13	performed	perform	VERB
cusj-12940	73	14	using	use	VERB
cusj-12940	73	15	microsoft	microsoft	PROPN
cusj-12940	73	16	excel	excel	PROPN
cusj-12940	73	17	.	.	PUNCT
cusj-12940	74	1	an	an	DET
cusj-12940	74	2	unpaired	unpaired	ADJ
cusj-12940	74	3	,	,	PUNCT
cusj-12940	74	4	two	two	NUM
cusj-12940	74	5	-	-	PUNCT
cusj-12940	74	6	tailed	tail	VERB
cusj-12940	74	7	t	t	NOUN
cusj-12940	74	8	-	-	PUNCT
cusj-12940	74	9	test	test	NOUN
cusj-12940	74	10	was	be	AUX
cusj-12940	74	11	performed	perform	VERB
cusj-12940	74	12	in	in	ADP
cusj-12940	74	13	excel	excel	NOUN
cusj-12940	74	14	,	,	PUNCT
cusj-12940	74	15	and	and	CCONJ
cusj-12940	74	16	a	a	DET
cusj-12940	74	17	p	p	NOUN
cusj-12940	74	18	-	-	PUNCT
cusj-12940	74	19	value	value	NOUN
cusj-12940	74	20	<	<	X
cusj-12940	74	21	0.05	0.05	NUM
cusj-12940	74	22	was	be	AUX
cusj-12940	74	23	considered	consider	VERB
cusj-12940	74	24	statistically	statistically	ADV
cusj-12940	74	25	significant	significant	ADJ
cusj-12940	74	26	.	.	PUNCT
cusj-12940	75	1	means	mean	NOUN
cusj-12940	75	2	and	and	CCONJ
cusj-12940	75	3	standard	standard	ADJ
cusj-12940	75	4	deviations	deviation	NOUN
cusj-12940	75	5	are	be	AUX
cusj-12940	75	6	taken	take	VERB
cusj-12940	75	7	for	for	ADP
cusj-12940	75	8	all	all	DET
cusj-12940	75	9	data	datum	NOUN
cusj-12940	75	10	and	and	CCONJ
cusj-12940	75	11	compared	compare	VERB
cusj-12940	75	12	as	as	ADP
cusj-12940	75	13	%	%	NOUN
cusj-12940	75	14	of	of	ADP
cusj-12940	75	15	control	control	NOUN
cusj-12940	75	16	.	.	PUNCT
cusj-12940	76	1	results	result	NOUN
cusj-12940	76	2	aebsf	aebsf	ADV
cusj-12940	76	3	reduces	reduce	VERB
cusj-12940	76	4	t98	t98	NOUN
cusj-12940	76	5	g	g	NOUN
cusj-12940	76	6	proliferation	proliferation	NOUN
cusj-12940	76	7	aebsf	aebsf	ADV
cusj-12940	76	8	was	be	AUX
cusj-12940	76	9	first	first	ADV
cusj-12940	76	10	demonstrated	demonstrate	VERB
cusj-12940	76	11	to	to	PART
cusj-12940	76	12	reduce	reduce	VERB
cusj-12940	76	13	proliferation	proliferation	NOUN
cusj-12940	76	14	in	in	ADP
cusj-12940	76	15	t98	t98	NOUN
cusj-12940	76	16	g	g	NOUN
cusj-12940	76	17	cells	cell	NOUN
cusj-12940	76	18	.	.	PUNCT
cusj-12940	77	1	as	as	ADP
cusj-12940	77	2	hypothesized	hypothesized	ADJ
cusj-12940	77	3	,	,	PUNCT
cusj-12940	77	4	aebsf	aebsf	ADV
cusj-12940	77	5	reduces	reduce	VERB
cusj-12940	77	6	proliferation	proliferation	NOUN
cusj-12940	77	7	in	in	ADP
cusj-12940	77	8	a	a	DET
cusj-12940	77	9	statistically	statistically	ADV
cusj-12940	77	10	significant	significant	ADJ
cusj-12940	77	11	manner	manner	NOUN
cusj-12940	77	12	,	,	PUNCT
cusj-12940	77	13	demonstrating	demonstrate	VERB
cusj-12940	77	14	the	the	DET
cusj-12940	77	15	efficacy	efficacy	NOUN
cusj-12940	77	16	of	of	ADP
cusj-12940	77	17	this	this	DET
cusj-12940	77	18	treatment	treatment	NOUN
cusj-12940	77	19	(	(	PUNCT
cusj-12940	77	20	fig	fig	NOUN
cusj-12940	77	21	.	.	PUNCT
cusj-12940	78	1	1a	1a	NUM
cusj-12940	78	2	)	)	PUNCT
cusj-12940	78	3	.	.	PUNCT
cusj-12940	79	1	aebsf	aebsf	PROPN
cusj-12940	79	2	decreases	decrease	VERB
cusj-12940	79	3	t98	t98	PROPN
cusj-12940	79	4	g	g	PROPN
cusj-12940	79	5	viability	viability	NOUN
cusj-12940	79	6	aebsf	aebsf	ADV
cusj-12940	79	7	was	be	AUX
cusj-12940	79	8	also	also	ADV
cusj-12940	79	9	demonstrated	demonstrate	VERB
cusj-12940	79	10	to	to	PART
cusj-12940	79	11	reduce	reduce	VERB
cusj-12940	79	12	viability	viability	NOUN
cusj-12940	79	13	in	in	ADP
cusj-12940	79	14	t98	t98	NOUN
cusj-12940	79	15	g	g	NOUN
cusj-12940	79	16	cells	cell	NOUN
cusj-12940	79	17	.	.	PUNCT
cusj-12940	80	1	specifically	specifically	ADV
cusj-12940	80	2	,	,	PUNCT
cusj-12940	80	3	higher	high	ADJ
cusj-12940	80	4	concentrations	concentration	NOUN
cusj-12940	80	5	of	of	ADP
cusj-12940	80	6	aebsf	aebsf	ADV
cusj-12940	80	7	were	be	AUX
cusj-12940	80	8	shown	show	VERB
cusj-12940	80	9	to	to	PART
cusj-12940	80	10	decrease	decrease	VERB
cusj-12940	80	11	the	the	DET
cusj-12940	80	12	number	number	NOUN
cusj-12940	80	13	of	of	ADP
cusj-12940	80	14	viable	viable	ADJ
cusj-12940	80	15	cells	cell	NOUN
cusj-12940	80	16	and	and	CCONJ
cusj-12940	80	17	increase	increase	VERB
cusj-12940	80	18	the	the	DET
cusj-12940	80	19	number	number	NOUN
cusj-12940	80	20	of	of	ADP
cusj-12940	80	21	dead	dead	ADJ
cusj-12940	80	22	cells	cell	NOUN
cusj-12940	80	23	(	(	PUNCT
cusj-12940	80	24	fig	fig	NOUN
cusj-12940	80	25	.	.	PUNCT
cusj-12940	81	1	2	2	NUM
cusj-12940	81	2	)	)	PUNCT
cusj-12940	81	3	.	.	PUNCT
cusj-12940	82	1	as	as	SCONJ
cusj-12940	82	2	hypothesized	hypothesized	ADJ
cusj-12940	82	3	,	,	PUNCT
cusj-12940	82	4	aebsf	aebsf	ADV
cusj-12940	82	5	reduces	reduce	VERB
cusj-12940	82	6	viability	viability	NOUN
cusj-12940	82	7	in	in	ADP
cusj-12940	82	8	a	a	DET
cusj-12940	82	9	statistically	statistically	ADV
cusj-12940	82	10	significant	significant	ADJ
cusj-12940	82	11	manner	manner	NOUN
cusj-12940	82	12	,	,	PUNCT
cusj-12940	82	13	once	once	ADV
cusj-12940	82	14	again	again	ADV
cusj-12940	82	15	demonstrating	demonstrate	VERB
cusj-12940	82	16	the	the	DET
cusj-12940	82	17	efficacy	efficacy	NOUN
cusj-12940	82	18	of	of	ADP
cusj-12940	82	19	this	this	DET
cusj-12940	82	20	treatment	treatment	NOUN
cusj-12940	82	21	(	(	PUNCT
cusj-12940	82	22	fig	fig	NOUN
cusj-12940	82	23	.	.	PUNCT
cusj-12940	83	1	2	2	NUM
cusj-12940	83	2	)	)	PUNCT
cusj-12940	83	3	.	.	PUNCT
cusj-12940	84	1	plasma	plasma	NOUN
cusj-12940	84	2	membrane	membrane	NOUN
cusj-12940	84	3	v	v	NOUN
cusj-12940	84	4	-	-	PUNCT
cusj-12940	84	5	atpase	atpase	NOUN
cusj-12940	84	6	subunit	subunit	NOUN
cusj-12940	84	7	a	a	DET
cusj-12940	84	8	(	(	PUNCT
cusj-12940	84	9	atp6v1a	atp6v1a	NUM
cusj-12940	84	10	)	)	PUNCT
cusj-12940	84	11	protein	protein	NOUN
cusj-12940	84	12	expression	expression	NOUN
cusj-12940	84	13	is	be	AUX
cusj-12940	84	14	enhanced	enhance	VERB
cusj-12940	84	15	in	in	ADP
cusj-12940	84	16	glioblastomas	glioblastoma	NOUN
cusj-12940	84	17	and	and	CCONJ
cusj-12940	84	18	decreased	decrease	VERB
cusj-12940	84	19	upon	upon	SCONJ
cusj-12940	84	20	aebsf	aebsf	ADJ
cusj-12940	84	21	treatment	treatment	NOUN
cusj-12940	84	22	v	v	NOUN
cusj-12940	84	23	-	-	PUNCT
cusj-12940	84	24	atpase	atpase	ADJ
cusj-12940	84	25	subunit	subunit	NOUN
cusj-12940	84	26	a	a	PRON
cusj-12940	84	27	(	(	PUNCT
cusj-12940	84	28	atp6v1a	atp6v1a	NUM
cusj-12940	84	29	)	)	PUNCT
cusj-12940	84	30	plays	play	VERB
cusj-12940	84	31	a	a	DET
cusj-12940	84	32	vital	vital	ADJ
cusj-12940	84	33	role	role	NOUN
cusj-12940	84	34	in	in	ADP
cusj-12940	84	35	the	the	DET
cusj-12940	84	36	primary	primary	ADJ
cusj-12940	84	37	function	function	NOUN
cusj-12940	84	38	of	of	ADP
cusj-12940	84	39	the	the	DET
cusj-12940	84	40	overall	overall	ADJ
cusj-12940	84	41	proton	proton	NOUN
cusj-12940	84	42	pump	pump	NOUN
cusj-12940	84	43	--	--	PUNCT
cusj-12940	84	44	acidification	acidification	NOUN
cusj-12940	84	45	of	of	ADP
cusj-12940	84	46	the	the	DET
cusj-12940	84	47	extracellular	extracellular	ADJ
cusj-12940	84	48	environment	environment	NOUN
cusj-12940	84	49	.	.	PUNCT
cusj-12940	85	1	through	through	ADP
cusj-12940	85	2	an	an	DET
cusj-12940	85	3	indirect	indirect	ADJ
cusj-12940	85	4	elisa	elisa	NOUN
cusj-12940	85	5	,	,	PUNCT
cusj-12940	85	6	it	it	PRON
cusj-12940	85	7	is	be	AUX
cusj-12940	85	8	demonstrated	demonstrate	VERB
cusj-12940	85	9	that	that	SCONJ
cusj-12940	85	10	atp6v1a	atp6v1a	VERB
cusj-12940	85	11	protein	protein	NOUN
cusj-12940	85	12	expression	expression	NOUN
cusj-12940	85	13	decreases	decrease	VERB
cusj-12940	85	14	with	with	ADP
cusj-12940	85	15	increasing	increase	VERB
cusj-12940	85	16	aebsf	aebsf	ADJ
cusj-12940	85	17	concentration	concentration	NOUN
cusj-12940	85	18	(	(	PUNCT
cusj-12940	85	19	fig	fig	NOUN
cusj-12940	85	20	.	.	PUNCT
cusj-12940	86	1	3	3	NUM
cusj-12940	86	2	)	)	PUNCT
cusj-12940	86	3	.	.	PUNCT
cusj-12940	87	1	aebsf	aebsf	PROPN
cusj-12940	87	2	targets	target	VERB
cusj-12940	87	3	serine	serine	NOUN
cusj-12940	87	4	proteases	protease	NOUN
cusj-12940	87	5	and	and	CCONJ
cusj-12940	87	6	metalloproteinases	metalloproteinase	NOUN
cusj-12940	87	7	aebsf	aebsf	ADV
cusj-12940	87	8	is	be	AUX
cusj-12940	87	9	a	a	DET
cusj-12940	87	10	well	well	ADV
cusj-12940	87	11	known	know	VERB
cusj-12940	87	12	serine	serine	NOUN
cusj-12940	87	13	protease	protease	NOUN
cusj-12940	87	14	inhibitor	inhibitor	NOUN
cusj-12940	87	15	.	.	PUNCT
cusj-12940	88	1	although	although	SCONJ
cusj-12940	88	2	it	it	PRON
cusj-12940	88	3	is	be	AUX
cusj-12940	88	4	known	know	VERB
cusj-12940	88	5	that	that	SCONJ
cusj-12940	88	6	aebsf	aebsf	ADV
cusj-12940	88	7	inhibits	inhibit	VERB
cusj-12940	88	8	serine	serine	NOUN
cusj-12940	88	9	proteases	protease	NOUN
cusj-12940	88	10	such	such	ADJ
cusj-12940	88	11	as	as	ADP
cusj-12940	88	12	trypsin	trypsin	NOUN
cusj-12940	88	13	and	and	CCONJ
cusj-12940	88	14	chymotrypsin	chymotrypsin	NOUN
cusj-12940	88	15	,	,	PUNCT
cusj-12940	88	16	shape	shape	NOUN
cusj-12940	88	17	-	-	PUNCT
cusj-12940	88	18	screening	screen	VERB
cusj-12940	88	19	tool	tool	NOUN
cusj-12940	88	20	chemmapper	chemmapper	NOUN
cusj-12940	88	21	was	be	AUX
cusj-12940	88	22	utilized	utilize	VERB
cusj-12940	88	23	to	to	PART
cusj-12940	88	24	predict	predict	VERB
cusj-12940	88	25	its	its	PRON
cusj-12940	88	26	protein	protein	NOUN
cusj-12940	88	27	targets	target	NOUN
cusj-12940	88	28	with	with	ADP
cusj-12940	88	29	the	the	DET
cusj-12940	88	30	highest	high	ADJ
cusj-12940	88	31	confidence	confidence	NOUN
cusj-12940	88	32	scores	score	NOUN
cusj-12940	88	33	.	.	PUNCT
cusj-12940	89	1	chemmapper	chemmapper	NOUN
cusj-12940	89	2	is	be	AUX
cusj-12940	89	3	fundamentally	fundamentally	ADV
cusj-12940	89	4	rooted	root	VERB
cusj-12940	89	5	in	in	ADP
cusj-12940	89	6	the	the	DET
cusj-12940	89	7	“	"	PUNCT
cusj-12940	89	8	chemical	chemical	ADJ
cusj-12940	89	9	similarity	similarity	NOUN
cusj-12940	89	10	principle	principle	NOUN
cusj-12940	89	11	”	"	PUNCT
cusj-12940	89	12	,	,	PUNCT
cusj-12940	89	13	which	which	PRON
cusj-12940	89	14	states	state	VERB
cusj-12940	89	15	that	that	SCONJ
cusj-12940	89	16	structurally	structurally	ADV
cusj-12940	89	17	similar	similar	ADJ
cusj-12940	89	18	compounds	compound	NOUN
cusj-12940	89	19	have	have	VERB
cusj-12940	89	20	similar	similar	ADJ
cusj-12940	89	21	bioactivies	bioactivie	NOUN
cusj-12940	89	22	[	[	X
cusj-12940	89	23	7	7	NUM
cusj-12940	89	24	]	]	PUNCT
cusj-12940	89	25	.	.	PUNCT
cusj-12940	90	1	thus	thus	ADV
cusj-12940	90	2	,	,	PUNCT
cusj-12940	90	3	it	it	PRON
cusj-12940	90	4	can	can	AUX
cusj-12940	90	5	be	be	AUX
cusj-12940	90	6	said	say	VERB
cusj-12940	90	7	that	that	SCONJ
cusj-12940	90	8	a	a	DET
cusj-12940	90	9	higher	high	ADJ
cusj-12940	90	10	similarity	similarity	NOUN
cusj-12940	90	11	score	score	NOUN
cusj-12940	90	12	between	between	ADP
cusj-12940	90	13	the	the	DET
cusj-12940	90	14	query	query	NOUN
cusj-12940	90	15	ligand	ligand	NOUN
cusj-12940	90	16	(	(	PUNCT
cusj-12940	90	17	aebsf	aebsf	ADV
cusj-12940	90	18	in	in	ADP
cusj-12940	90	19	this	this	DET
cusj-12940	90	20	study	study	NOUN
cusj-12940	90	21	)	)	PUNCT
cusj-12940	90	22	and	and	CCONJ
cusj-12940	90	23	the	the	DET
cusj-12940	90	24	database	database	NOUN
cusj-12940	90	25	ligands	ligand	NOUN
cusj-12940	90	26	indicates	indicate	VERB
cusj-12940	90	27	a	a	DET
cusj-12940	90	28	higher	high	ADJ
cusj-12940	90	29	likelihood	likelihood	NOUN
cusj-12940	90	30	that	that	SCONJ
cusj-12940	90	31	a	a	DET
cusj-12940	90	32	given	give	VERB
cusj-12940	90	33	protein	protein	NOUN
cusj-12940	90	34	target	target	NOUN
cusj-12940	90	35	of	of	ADP
cusj-12940	90	36	the	the	DET
cusj-12940	90	37	database	database	NOUN
cusj-12940	90	38	ligand	ligand	NOUN
cusj-12940	90	39	is	be	AUX
cusj-12940	90	40	also	also	ADV
cusj-12940	90	41	a	a	DET
cusj-12940	90	42	target	target	NOUN
cusj-12940	90	43	of	of	ADP
cusj-12940	90	44	aebsf	aebsf	ADJ
cusj-12940	90	45	,	,	PUNCT
cusj-12940	90	46	the	the	DET
cusj-12940	90	47	query	query	NOUN
cusj-12940	90	48	ligand	ligand	NOUN
cusj-12940	90	49	.	.	PUNCT
cusj-12940	91	1	thus	thus	ADV
cusj-12940	91	2	,	,	PUNCT
cusj-12940	91	3	as	as	SCONJ
cusj-12940	91	4	previously	previously	ADV
cusj-12940	91	5	discussed	discuss	VERB
cusj-12940	91	6	,	,	PUNCT
cusj-12940	91	7	a	a	DET
cusj-12940	91	8	similarity	similarity	NOUN
cusj-12940	91	9	threshold	threshold	NOUN
cusj-12940	91	10	of	of	ADP
cusj-12940	91	11	1.2	1.2	NUM
cusj-12940	91	12	(	(	PUNCT
cusj-12940	91	13	on	on	ADP
cusj-12940	91	14	a	a	DET
cusj-12940	91	15	scale	scale	NOUN
cusj-12940	91	16	of	of	ADP
cusj-12940	91	17	2.0	2.0	NUM
cusj-12940	91	18	)	)	PUNCT
cusj-12940	91	19	was	be	AUX
cusj-12940	91	20	set	set	VERB
cusj-12940	91	21	in	in	ADP
cusj-12940	91	22	order	order	NOUN
cusj-12940	91	23	to	to	PART
cusj-12940	91	24	filter	filter	VERB
cusj-12940	91	25	out	out	ADP
cusj-12940	91	26	protein	protein	NOUN
cusj-12940	91	27	targets	target	NOUN
cusj-12940	91	28	of	of	ADP
cusj-12940	91	29	database	database	NOUN
cusj-12940	91	30	ligands	ligand	NOUN
cusj-12940	91	31	with	with	ADP
cusj-12940	91	32	low	low	ADJ
cusj-12940	91	33	-	-	PUNCT
cusj-12940	91	34	similarity	similarity	NOUN
cusj-12940	91	35	scores	score	NOUN
cusj-12940	91	36	.	.	PUNCT
cusj-12940	92	1	using	use	VERB
cusj-12940	92	2	chemmapper	chemmapper	NOUN
cusj-12940	92	3	,	,	PUNCT
cusj-12940	92	4	it	it	PRON
cusj-12940	92	5	was	be	AUX
cusj-12940	92	6	predicted	predict	VERB
cusj-12940	92	7	that	that	SCONJ
cusj-12940	92	8	aebsf	aebsf	ADJ
cusj-12940	92	9	targets	target	VERB
cusj-12940	92	10	6	6	NUM
cusj-12940	92	11	serine	serine	NOUN
cusj-12940	92	12	proteases	protease	NOUN
cusj-12940	92	13	(	(	PUNCT
cusj-12940	92	14	fig	fig	NOUN
cusj-12940	92	15	.	.	PUNCT
cusj-12940	92	16	4a	4a	NOUN
cusj-12940	92	17	)	)	PUNCT
cusj-12940	92	18	and	and	CCONJ
cusj-12940	92	19	2	2	NUM
cusj-12940	92	20	metalloproteinases	metalloproteinase	NOUN
cusj-12940	92	21	(	(	PUNCT
cusj-12940	92	22	fig	fig	NOUN
cusj-12940	92	23	.	.	PUNCT
cusj-12940	93	1	4b	4b	PROPN
cusj-12940	93	2	)	)	PUNCT
cusj-12940	93	3	.	.	PUNCT
cusj-12940	94	1	serine	serine	NOUN
cusj-12940	94	2	proteases	protease	NOUN
cusj-12940	94	3	and	and	CCONJ
cusj-12940	94	4	metalloproteinases	metalloproteinase	NOUN
cusj-12940	94	5	targeted	target	VERB
cusj-12940	94	6	by	by	ADP
cusj-12940	94	7	aebsf	aebsf	ADV
cusj-12940	94	8	primarily	primarily	ADV
cusj-12940	94	9	play	play	VERB
cusj-12940	94	10	a	a	DET
cusj-12940	94	11	role	role	NOUN
cusj-12940	94	12	in	in	ADP
cusj-12940	94	13	extracellular	extracellular	ADJ
cusj-12940	94	14	matrix	matrix	NOUN
cusj-12940	94	15	disassembly	disassembly	NOUN
cusj-12940	94	16	and	and	CCONJ
cusj-12940	94	17	cell	cell	NOUN
cusj-12940	94	18	migration	migration	NOUN
cusj-12940	94	19	in	in	ADP
cusj-12940	94	20	glioblastomas	glioblastoma	NOUN
cusj-12940	94	21	the	the	DET
cusj-12940	94	22	eight	eight	NUM
cusj-12940	94	23	protein	protein	NOUN
cusj-12940	94	24	targets	target	NOUN
cusj-12940	94	25	predicted	predict	VERB
cusj-12940	94	26	by	by	ADP
cusj-12940	94	27	chemmap	chemmap	NOUN
cusj-12940	94	28	were	be	AUX
cusj-12940	94	29	plugged	plug	VERB
cusj-12940	94	30	into	into	ADP
cusj-12940	94	31	“	"	PUNCT
cusj-12940	94	32	search	search	NOUN
cusj-12940	94	33	tool	tool	NOUN
cusj-12940	94	34	for	for	ADP
cusj-12940	94	35	the	the	DET
cusj-12940	94	36	retrieval	retrieval	NOUN
cusj-12940	94	37	of	of	ADP
cusj-12940	94	38	interacting	interact	VERB
cusj-12940	94	39	genes	gene	NOUN
cusj-12940	94	40	/	/	SYM
cusj-12940	94	41	proteins	protein	NOUN
cusj-12940	94	42	”	"	PUNCT
cusj-12940	94	43	(	(	PUNCT
cusj-12940	94	44	string	string	NOUN
cusj-12940	94	45	)	)	PUNCT
cusj-12940	94	46	to	to	PART
cusj-12940	94	47	carry	carry	VERB
cusj-12940	94	48	out	out	ADP
cusj-12940	94	49	an	an	DET
cusj-12940	94	50	enrichment	enrichment	NOUN
cusj-12940	94	51	analysis	analysis	NOUN
cusj-12940	94	52	of	of	ADP
cusj-12940	94	53	the	the	DET
cusj-12940	94	54	biological	biological	ADJ
cusj-12940	94	55	processes	process	NOUN
cusj-12940	94	56	that	that	PRON
cusj-12940	94	57	they	they	PRON
cusj-12940	94	58	are	be	AUX
cusj-12940	94	59	involved	involve	VERB
cusj-12940	94	60	in	in	ADP
cusj-12940	94	61	.	.	PUNCT
cusj-12940	95	1	the	the	DET
cusj-12940	95	2	top	top	ADJ
cusj-12940	95	3	five	five	NUM
cusj-12940	95	4	biological	biological	ADJ
cusj-12940	95	5	processes	process	NOUN
cusj-12940	95	6	,	,	PUNCT
cusj-12940	95	7	along	along	ADP
cusj-12940	95	8	with	with	ADP
cusj-12940	95	9	their	their	PRON
cusj-12940	95	10	false	false	ADJ
cusj-12940	95	11	discovery	discovery	NOUN
cusj-12940	95	12	rates	rate	NOUN
cusj-12940	95	13	(	(	PUNCT
cusj-12940	95	14	fdrs	fdrs	PROPN
cusj-12940	95	15	)	)	PUNCT
cusj-12940	95	16	and	and	CCONJ
cusj-12940	95	17	strength	strength	NOUN
cusj-12940	95	18	values	value	NOUN
cusj-12940	95	19	,	,	PUNCT
cusj-12940	95	20	were	be	AUX
cusj-12940	95	21	analyzed	analyze	VERB
cusj-12940	95	22	(	(	PUNCT
cusj-12940	95	23	fig	fig	NOUN
cusj-12940	95	24	.	.	PUNCT
cusj-12940	96	1	5	5	NUM
cusj-12940	96	2	)	)	PUNCT
cusj-12940	96	3	.	.	PUNCT
cusj-12940	97	1	columbia	columbia	PROPN
cusj-12940	97	2	undergraduate	undergraduate	PROPN
cusj-12940	97	3	science	science	PROPN
cusj-12940	97	4	journal	journal	PROPN
cusj-12940	97	5	vol	vol	NOUN
cusj-12940	97	6	.	.	PROPN
cusj-12940	98	1	16	16	NUM
cusj-12940	98	2	,	,	PUNCT
cusj-12940	98	3	2022	2022	NUM
cusj-12940	98	4	20	20	NUM
cusj-12940	98	5	figure	figure	NOUN
cusj-12940	98	6	1	1	NUM
cusj-12940	98	7	.	.	X
cusj-12940	98	8	48	48	NUM
cusj-12940	98	9	-	-	PUNCT
cusj-12940	98	10	hour	hour	NOUN
cusj-12940	98	11	treatment	treatment	NOUN
cusj-12940	98	12	with	with	ADP
cusj-12940	98	13	4	4	NUM
cusj-12940	98	14	-	-	PUNCT
cusj-12940	98	15	benzenesulfonyl	benzenesulfonyl	NOUN
cusj-12940	98	16	fluoride	fluoride	NOUN
cusj-12940	98	17	hydrochloride	hydrochloride	NOUN
cusj-12940	98	18	(	(	PUNCT
cusj-12940	98	19	aebsf	aebsf	ADV
cusj-12940	98	20	)	)	PUNCT
cusj-12940	98	21	reduces	reduce	VERB
cusj-12940	98	22	proliferation	proliferation	NOUN
cusj-12940	98	23	in	in	ADP
cusj-12940	98	24	t98	t98	NOUN
cusj-12940	98	25	g	g	NOUN
cusj-12940	98	26	cells	cell	NOUN
cusj-12940	98	27	.	.	PUNCT
cusj-12940	99	1	a	a	DET
cusj-12940	99	2	:	:	PUNCT
cusj-12940	99	3	bars	bar	NOUN
cusj-12940	99	4	are	be	AUX
cusj-12940	99	5	means	mean	VERB
cusj-12940	99	6	±	±	NUM
cusj-12940	99	7	stdev	stdev	NOUN
cusj-12940	99	8	(	(	PUNCT
cusj-12940	99	9	n=4	n=4	NOUN
cusj-12940	99	10	)	)	PUNCT
cusj-12940	99	11	.	.	PUNCT
cusj-12940	100	1	*	*	PUNCT
cusj-12940	100	2	significantly	significantly	ADV
cusj-12940	100	3	different	different	ADJ
cusj-12940	100	4	by	by	ADP
cusj-12940	100	5	t	t	PROPN
cusj-12940	100	6	-	-	PUNCT
cusj-12940	100	7	test	test	NOUN
cusj-12940	100	8	at	at	ADP
cusj-12940	100	9	p<0.05	p<0.05	NOUN
cusj-12940	100	10	comparing	compare	VERB
cusj-12940	100	11	data	datum	NOUN
cusj-12940	100	12	to	to	ADP
cusj-12940	100	13	that	that	PRON
cusj-12940	100	14	at	at	ADP
cusj-12940	100	15	vehicle	vehicle	NOUN
cusj-12940	100	16	control	control	NOUN
cusj-12940	100	17	(	(	PUNCT
cusj-12940	100	18	cells	cell	NOUN
cusj-12940	100	19	and	and	CCONJ
cusj-12940	100	20	h2o	h2o	NOUN
cusj-12940	100	21	)	)	PUNCT
cusj-12940	100	22	.	.	PUNCT
cusj-12940	101	1	*	*	PUNCT
cusj-12940	101	2	*	*	PUNCT
cusj-12940	101	3	significantly	significantly	ADV
cusj-12940	101	4	different	different	ADJ
cusj-12940	101	5	by	by	ADP
cusj-12940	101	6	t	t	PROPN
cusj-12940	101	7	-	-	PUNCT
cusj-12940	101	8	test	test	NOUN
cusj-12940	101	9	at	at	ADP
cusj-12940	101	10	p<0.01	p<0.01	PROPN
cusj-12940	101	11	comparing	compare	VERB
cusj-12940	101	12	data	datum	NOUN
cusj-12940	101	13	to	to	ADP
cusj-12940	101	14	that	that	PRON
cusj-12940	101	15	at	at	ADP
cusj-12940	101	16	vehicle	vehicle	NOUN
cusj-12940	101	17	control	control	NOUN
cusj-12940	101	18	.	.	PUNCT
cusj-12940	102	1	*	*	PUNCT
cusj-12940	103	1	*	*	PUNCT
cusj-12940	103	2	*	*	PUNCT
cusj-12940	103	3	significantly	significantly	ADV
cusj-12940	103	4	different	different	ADJ
cusj-12940	103	5	by	by	ADP
cusj-12940	103	6	t	t	PROPN
cusj-12940	103	7	-	-	PUNCT
cusj-12940	103	8	test	test	NOUN
cusj-12940	103	9	at	at	ADP
cusj-12940	103	10	p<0.001	p<0.001	NOUN
cusj-12940	103	11	comparing	compare	VERB
cusj-12940	103	12	data	datum	NOUN
cusj-12940	103	13	to	to	ADP
cusj-12940	103	14	that	that	PRON
cusj-12940	103	15	at	at	ADP
cusj-12940	103	16	vehicle	vehicle	NOUN
cusj-12940	103	17	control	control	NOUN
cusj-12940	103	18	.	.	PUNCT
cusj-12940	104	1	b	b	X
cusj-12940	104	2	:	:	PUNCT
cusj-12940	104	3	light	light	ADJ
cusj-12940	104	4	microscopy	microscopy	NOUN
cusj-12940	104	5	images	image	NOUN
cusj-12940	104	6	of	of	ADP
cusj-12940	104	7	t98	t98	NOUN
cusj-12940	104	8	g	g	PROPN
cusj-12940	104	9	treated	treat	VERB
cusj-12940	104	10	with	with	ADP
cusj-12940	104	11	125	125	NUM
cusj-12940	104	12	µm	µm	NOUN
cusj-12940	104	13	,	,	PUNCT
cusj-12940	104	14	500	500	NUM
cusj-12940	104	15	µm	µm	NOUN
cusj-12940	104	16	,	,	PUNCT
cusj-12940	104	17	or	or	CCONJ
cusj-12940	104	18	2000	2000	NUM
cusj-12940	104	19	µm	µm	NOUN
cusj-12940	104	20	aebsf	aebsf	ADV
cusj-12940	104	21	at	at	ADP
cusj-12940	104	22	100x	100x	NUM
cusj-12940	104	23	.	.	PUNCT
cusj-12940	105	1	figure	figure	NOUN
cusj-12940	105	2	2	2	NUM
cusj-12940	105	3	.	.	NOUN
cusj-12940	105	4	48	48	NUM
cusj-12940	105	5	-	-	PUNCT
cusj-12940	105	6	hour	hour	NOUN
cusj-12940	105	7	treatment	treatment	NOUN
cusj-12940	105	8	with	with	ADP
cusj-12940	105	9	4	4	NUM
cusj-12940	105	10	-	-	PUNCT
cusj-12940	105	11	benzenesulfonyl	benzenesulfonyl	NOUN
cusj-12940	105	12	fluoride	fluoride	NOUN
cusj-12940	105	13	hydrochloride	hydrochloride	NOUN
cusj-12940	105	14	(	(	PUNCT
cusj-12940	105	15	aebsf	aebsf	ADV
cusj-12940	105	16	)	)	PUNCT
cusj-12940	105	17	reduces	reduce	VERB
cusj-12940	105	18	viability	viability	NOUN
cusj-12940	105	19	in	in	ADP
cusj-12940	105	20	t98	t98	NOUN
cusj-12940	105	21	g	g	PROPN
cusj-12940	105	22	cells	cell	NOUN
cusj-12940	105	23	.	.	PUNCT
cusj-12940	106	1	columbia	columbia	PROPN
cusj-12940	106	2	undergraduate	undergraduate	PROPN
cusj-12940	106	3	science	science	PROPN
cusj-12940	106	4	journal	journal	PROPN
cusj-12940	106	5	vol	vol	NOUN
cusj-12940	106	6	.	.	PROPN
cusj-12940	107	1	16	16	NUM
cusj-12940	107	2	,	,	PUNCT
cusj-12940	107	3	2022	2022	NUM
cusj-12940	107	4	21	21	NUM
cusj-12940	107	5	figure	figure	NOUN
cusj-12940	107	6	3	3	NUM
cusj-12940	107	7	.	.	PUNCT
cusj-12940	107	8	atp6v1a	atp6v1a	PROPN
cusj-12940	107	9	elisa	elisa	PROPN
cusj-12940	107	10	on	on	ADP
cusj-12940	107	11	t98	t98	NOUN
cusj-12940	107	12	g	g	PROPN
cusj-12940	107	13	cells	cell	NOUN
cusj-12940	107	14	treated	treat	VERB
cusj-12940	107	15	with	with	ADP
cusj-12940	107	16	4	4	NUM
cusj-12940	107	17	-	-	PUNCT
cusj-12940	107	18	benzenesulfonyl	benzenesulfonyl	NOUN
cusj-12940	107	19	fluoride	fluoride	NOUN
cusj-12940	107	20	hydrochloride	hydrochloride	NOUN
cusj-12940	107	21	(	(	PUNCT
cusj-12940	107	22	aebsf	aebsf	ADV
cusj-12940	107	23	)	)	PUNCT
cusj-12940	107	24	for	for	ADP
cusj-12940	107	25	48	48	NUM
cusj-12940	107	26	hours	hour	NOUN
cusj-12940	107	27	.	.	PUNCT
cusj-12940	108	1	48	48	NUM
cusj-12940	108	2	-	-	PUNCT
cusj-12940	108	3	hour	hour	NOUN
cusj-12940	108	4	treatment	treatment	NOUN
cusj-12940	108	5	with	with	ADP
cusj-12940	108	6	aebsf	aebsf	ADJ
cusj-12940	108	7	reduces	reduce	VERB
cusj-12940	108	8	atp6v1a	atp6v1a	VERB
cusj-12940	108	9	protein	protein	NOUN
cusj-12940	108	10	expression	expression	NOUN
cusj-12940	108	11	in	in	ADP
cusj-12940	108	12	t98	t98	PROPN
cusj-12940	108	13	g.	g.	PROPN
cusj-12940	108	14	figure	figure	NOUN
cusj-12940	108	15	4	4	NUM
cusj-12940	108	16	.	.	PUNCT
cusj-12940	109	1	reverse	reverse	ADJ
cusj-12940	109	2	docking	dock	VERB
cusj-12940	109	3	analysis	analysis	NOUN
cusj-12940	109	4	of	of	ADP
cusj-12940	109	5	4	4	NUM
cusj-12940	109	6	-	-	PUNCT
cusj-12940	109	7	benzenesulfonyl	benzenesulfonyl	NOUN
cusj-12940	109	8	fluoride	fluoride	NOUN
cusj-12940	109	9	hydrochloride	hydrochloride	NOUN
cusj-12940	109	10	(	(	PUNCT
cusj-12940	109	11	aebsf	aebsf	ADV
cusj-12940	109	12	)	)	PUNCT
cusj-12940	109	13	using	use	VERB
cusj-12940	109	14	chemmapper	chemmapper	NOUN
cusj-12940	109	15	.	.	PUNCT
cusj-12940	110	1	z	z	NOUN
cusj-12940	110	2	-	-	PUNCT
cusj-12940	110	3	scores	score	NOUN
cusj-12940	110	4	and	and	CCONJ
cusj-12940	110	5	similarity	similarity	NOUN
cusj-12940	110	6	scores	score	NOUN
cusj-12940	110	7	of	of	ADP
cusj-12940	110	8	each	each	DET
cusj-12940	110	9	predicted	predict	VERB
cusj-12940	110	10	target	target	NOUN
cusj-12940	110	11	are	be	AUX
cusj-12940	110	12	displayed	display	VERB
cusj-12940	110	13	.	.	PUNCT
cusj-12940	111	1	the	the	DET
cusj-12940	111	2	similarity	similarity	NOUN
cusj-12940	111	3	score	score	NOUN
cusj-12940	111	4	ranges	range	VERB
cusj-12940	111	5	from	from	ADP
cusj-12940	111	6	[	[	X
cusj-12940	111	7	0	0	NUM
cusj-12940	111	8	,	,	PUNCT
cusj-12940	111	9	2	2	NUM
cusj-12940	111	10	]	]	PUNCT
cusj-12940	111	11	.	.	PUNCT
cusj-12940	112	1	the	the	PRON
cusj-12940	112	2	closer	close	ADV
cusj-12940	112	3	the	the	DET
cusj-12940	112	4	score	score	NOUN
cusj-12940	112	5	is	be	AUX
cusj-12940	112	6	to	to	ADP
cusj-12940	112	7	2.0	2.0	NUM
cusj-12940	112	8	,	,	PUNCT
cusj-12940	112	9	the	the	PRON
cusj-12940	112	10	higher	high	ADJ
cusj-12940	112	11	the	the	DET
cusj-12940	112	12	potential	potential	NOUN
cusj-12940	112	13	of	of	ADP
cusj-12940	112	14	pharmacological	pharmacological	ADJ
cusj-12940	112	15	association	association	NOUN
cusj-12940	112	16	there	there	PRON
cusj-12940	112	17	is	be	VERB
cusj-12940	112	18	between	between	ADP
cusj-12940	112	19	aebsf	aebsf	ADJ
cusj-12940	112	20	and	and	CCONJ
cusj-12940	112	21	the	the	DET
cusj-12940	112	22	database	database	NOUN
cusj-12940	112	23	ligands	ligand	NOUN
cusj-12940	112	24	of	of	ADP
cusj-12940	112	25	the	the	DET
cusj-12940	112	26	outputted	outputted	ADJ
cusj-12940	112	27	protein	protein	NOUN
cusj-12940	112	28	targets	target	NOUN
cusj-12940	112	29	^similarity	^similarity	ADP
cusj-12940	112	30	score	score	NOUN
cusj-12940	112	31	ranges	range	NOUN
cusj-12940	112	32	between	between	ADP
cusj-12940	112	33	1.2	1.2	NUM
cusj-12940	112	34	-	-	SYM
cusj-12940	112	35	1.4	1.4	NUM
cusj-12940	112	36	^^similarity	^^similarity	NOUN
cusj-12940	112	37	score	score	NOUN
cusj-12940	112	38	ranges	range	VERB
cusj-12940	112	39	between	between	ADP
cusj-12940	112	40	1.4	1.4	NUM
cusj-12940	112	41	-	-	SYM
cusj-12940	112	42	1.6	1.6	NUM
cusj-12940	112	43	#	#	SYM
cusj-12940	112	44	z	z	NOUN
cusj-12940	112	45	-	-	PUNCT
cusj-12940	112	46	score<0.5	score<0.5	VERB
cusj-12940	112	47	#	#	SYM
cusj-12940	112	48	#	#	NOUN
cusj-12940	112	49	z	z	NOUN
cusj-12940	112	50	-	-	NOUN
cusj-12940	112	51	score<0.1	score<0.1	ADJ
cusj-12940	113	1	#	#	SYM
cusj-12940	113	2	#	#	SYM
cusj-12940	113	3	#	#	NOUN
cusj-12940	113	4	z	z	NOUN
cusj-12940	113	5	-	-	PUNCT
cusj-12940	113	6	score<0.01	score<0.01	VERB
cusj-12940	113	7	a	a	DET
cusj-12940	113	8	:	:	PUNCT
cusj-12940	113	9	aebsf	aebsf	ADJ
cusj-12940	113	10	targets	target	NOUN
cusj-12940	113	11	serine	serine	NOUN
cusj-12940	113	12	proteases	protease	NOUN
cusj-12940	113	13	chymotrypsin	chymotrypsin	VERB
cusj-12940	113	14	-	-	PUNCT
cusj-12940	113	15	c	c	PROPN
cusj-12940	113	16	,	,	PUNCT
cusj-12940	113	17	trypsin-1	trypsin-1	PROPN
cusj-12940	113	18	,	,	PUNCT
cusj-12940	113	19	trypsin-2	trypsin-2	NUM
cusj-12940	113	20	,	,	PUNCT
cusj-12940	113	21	neutrophil	neutrophil	ADJ
cusj-12940	113	22	elastase	elastase	NOUN
cusj-12940	113	23	,	,	PUNCT
cusj-12940	113	24	urokinase	urokinase	NOUN
cusj-12940	113	25	-	-	PUNCT
cusj-12940	113	26	type	type	NOUN
cusj-12940	113	27	plasminogen	plasminogen	NOUN
cusj-12940	113	28	activator	activator	NOUN
cusj-12940	113	29	,	,	PUNCT
cusj-12940	113	30	and	and	CCONJ
cusj-12940	113	31	prothrombin	prothrombin	NOUN
cusj-12940	113	32	.	.	PUNCT
cusj-12940	114	1	b	b	X
cusj-12940	114	2	:	:	PUNCT
cusj-12940	114	3	aebsf	aebsf	ADJ
cusj-12940	114	4	targets	target	NOUN
cusj-12940	114	5	matrix	matrix	NOUN
cusj-12940	114	6	metalloproteinase-9	metalloproteinase-9	NUM
cusj-12940	114	7	(	(	PUNCT
cusj-12940	114	8	mmp9	mmp9	PROPN
cusj-12940	114	9	)	)	PUNCT
cusj-12940	115	1	and	and	CCONJ
cusj-12940	115	2	matrix	matrix	VERB
cusj-12940	115	3	metalloproteinase-14	metalloproteinase-14	NOUN
cusj-12940	115	4	(	(	PUNCT
cusj-12940	115	5	mmp14	mmp14	PROPN
cusj-12940	115	6	)	)	PUNCT
cusj-12940	115	7	.	.	PUNCT
cusj-12940	116	1	columbia	columbia	PROPN
cusj-12940	116	2	undergraduate	undergraduate	PROPN
cusj-12940	116	3	science	science	PROPN
cusj-12940	116	4	journal	journal	PROPN
cusj-12940	116	5	vol	vol	NOUN
cusj-12940	116	6	.	.	PROPN
cusj-12940	117	1	16	16	NUM
cusj-12940	117	2	,	,	PUNCT
cusj-12940	117	3	2022	2022	NUM
cusj-12940	117	4	22	22	NUM
cusj-12940	117	5	figure	figure	NOUN
cusj-12940	117	6	5	5	NUM
cusj-12940	117	7	.	.	PUNCT
cusj-12940	117	8	biological	biological	ADJ
cusj-12940	117	9	process	process	NOUN
cusj-12940	117	10	enrichment	enrichment	NOUN
cusj-12940	117	11	analysis	analysis	NOUN
cusj-12940	117	12	of	of	ADP
cusj-12940	117	13	aebsf	aebsf	ADJ
cusj-12940	117	14	serine	serine	NOUN
cusj-12940	117	15	protease	protease	NOUN
cusj-12940	117	16	(	(	PUNCT
cusj-12940	117	17	chymotrypsin	chymotrypsin	NOUN
cusj-12940	117	18	-	-	PUNCT
cusj-12940	117	19	c	c	PROPN
cusj-12940	117	20	,	,	PUNCT
cusj-12940	117	21	trypsin-1	trypsin-1	PROPN
cusj-12940	117	22	,	,	PUNCT
cusj-12940	117	23	trypsin-2	trypsin-2	NUM
cusj-12940	117	24	,	,	PUNCT
cusj-12940	117	25	neutrophil	neutrophil	ADJ
cusj-12940	117	26	elastase	elastase	NOUN
cusj-12940	117	27	,	,	PUNCT
cusj-12940	117	28	urokinase	urokinase	NOUN
cusj-12940	117	29	-	-	PUNCT
cusj-12940	117	30	type	type	NOUN
cusj-12940	117	31	plasminogen	plasminogen	NOUN
cusj-12940	117	32	activator	activator	NOUN
cusj-12940	117	33	,	,	PUNCT
cusj-12940	117	34	prothrombin	prothrombin	NOUN
cusj-12940	117	35	)	)	PUNCT
cusj-12940	117	36	and	and	CCONJ
cusj-12940	117	37	metalloproteinase	metalloproteinase	NOUN
cusj-12940	117	38	(	(	PUNCT
cusj-12940	117	39	mmp9	mmp9	PROPN
cusj-12940	117	40	,	,	PUNCT
cusj-12940	117	41	mmp14	mmp14	PROPN
cusj-12940	117	42	)	)	PUNCT
cusj-12940	117	43	targets	target	NOUN
cusj-12940	117	44	.	.	PUNCT
cusj-12940	118	1	search	search	NOUN
cusj-12940	118	2	tool	tool	NOUN
cusj-12940	118	3	for	for	ADP
cusj-12940	118	4	the	the	DET
cusj-12940	118	5	retrieval	retrieval	NOUN
cusj-12940	118	6	of	of	ADP
cusj-12940	118	7	interacting	interact	VERB
cusj-12940	118	8	genes	gene	NOUN
cusj-12940	118	9	/	/	SYM
cusj-12940	118	10	proteins	protein	NOUN
cusj-12940	118	11	(	(	PUNCT
cusj-12940	118	12	string	string	NOUN
cusj-12940	118	13	)	)	PUNCT
cusj-12940	118	14	was	be	AUX
cusj-12940	118	15	utilized	utilize	VERB
cusj-12940	118	16	for	for	ADP
cusj-12940	118	17	this	this	DET
cusj-12940	118	18	analysis	analysis	NOUN
cusj-12940	118	19	.	.	PUNCT
cusj-12940	119	1	false	false	ADJ
cusj-12940	119	2	discovery	discovery	NOUN
cusj-12940	119	3	rates	rate	NOUN
cusj-12940	119	4	(	(	PUNCT
cusj-12940	119	5	fdrs	fdrs	PROPN
cusj-12940	119	6	)	)	PUNCT
cusj-12940	119	7	and	and	CCONJ
cusj-12940	119	8	strength	strength	NOUN
cusj-12940	119	9	values	value	NOUN
cusj-12940	119	10	are	be	AUX
cusj-12940	119	11	displayed	display	VERB
cusj-12940	119	12	;	;	PUNCT
cusj-12940	119	13	p	p	X
cusj-12940	119	14	=	=	PROPN
cusj-12940	119	15	7.61e-1	7.61e-1	NOUN
cusj-12940	119	16	.	.	PUNCT
cusj-12940	120	1	five	five	NUM
cusj-12940	120	2	biological	biological	ADJ
cusj-12940	120	3	processes	process	NOUN
cusj-12940	120	4	with	with	ADP
cusj-12940	120	5	the	the	DET
cusj-12940	120	6	highest	high	ADJ
cusj-12940	120	7	strength	strength	NOUN
cusj-12940	120	8	values	value	NOUN
cusj-12940	120	9	are	be	AUX
cusj-12940	120	10	displayed	display	VERB
cusj-12940	120	11	.	.	PUNCT
cusj-12940	121	1	aebsf	aebsf	PROPN
cusj-12940	121	2	downregulates	downregulate	VERB
cusj-12940	121	3	elane	elane	NOUN
cusj-12940	121	4	and	and	CCONJ
cusj-12940	121	5	mmp9	mmp9	VERB
cusj-12940	121	6	protein	protein	NOUN
cusj-12940	121	7	expression	expression	NOUN
cusj-12940	121	8	following	follow	VERB
cusj-12940	121	9	the	the	DET
cusj-12940	121	10	reverse	reverse	ADJ
cusj-12940	121	11	docking	docking	NOUN
cusj-12940	121	12	and	and	CCONJ
cusj-12940	121	13	biological	biological	ADJ
cusj-12940	121	14	processes	process	NOUN
cusj-12940	121	15	enrichment	enrichment	NOUN
cusj-12940	121	16	analyses	analysis	NOUN
cusj-12940	121	17	,	,	PUNCT
cusj-12940	121	18	neutrophil	neutrophil	ADJ
cusj-12940	121	19	elastase	elastase	NOUN
cusj-12940	121	20	(	(	PUNCT
cusj-12940	121	21	elane	elane	NOUN
cusj-12940	121	22	)	)	PUNCT
cusj-12940	121	23	and	and	CCONJ
cusj-12940	121	24	matrix	matrix	NOUN
cusj-12940	121	25	metalloproteinase-9	metalloproteinase-9	NUM
cusj-12940	121	26	(	(	PUNCT
cusj-12940	121	27	mmp9	mmp9	ADJ
cusj-12940	121	28	)	)	PUNCT
cusj-12940	121	29	expression	expression	NOUN
cusj-12940	121	30	were	be	AUX
cusj-12940	121	31	selected	select	VERB
cusj-12940	121	32	to	to	PART
cusj-12940	121	33	be	be	AUX
cusj-12940	121	34	analyzed	analyze	VERB
cusj-12940	121	35	.	.	PUNCT
cusj-12940	122	1	these	these	DET
cusj-12940	122	2	two	two	NUM
cusj-12940	122	3	proteins	protein	NOUN
cusj-12940	122	4	were	be	AUX
cusj-12940	122	5	selected	select	VERB
cusj-12940	122	6	to	to	PART
cusj-12940	122	7	be	be	AUX
cusj-12940	122	8	studied	study	VERB
cusj-12940	122	9	,	,	PUNCT
cusj-12940	122	10	as	as	SCONJ
cusj-12940	122	11	in	in	ADP
cusj-12940	122	12	the	the	DET
cusj-12940	122	13	reverse	reverse	ADJ
cusj-12940	122	14	docking	docking	NOUN
cusj-12940	122	15	analysis	analysis	NOUN
cusj-12940	122	16	,	,	PUNCT
cusj-12940	122	17	elane	elane	NOUN
cusj-12940	122	18	and	and	CCONJ
cusj-12940	122	19	mmp9	mmp9	PROPN
cusj-12940	122	20	were	be	AUX
cusj-12940	122	21	demonstrated	demonstrate	VERB
cusj-12940	122	22	to	to	PART
cusj-12940	122	23	have	have	VERB
cusj-12940	122	24	the	the	DET
cusj-12940	122	25	highest	high	ADJ
cusj-12940	122	26	similarity	similarity	NOUN
cusj-12940	122	27	scores	score	NOUN
cusj-12940	122	28	,	,	PUNCT
cusj-12940	122	29	which	which	PRON
cusj-12940	122	30	was	be	AUX
cusj-12940	122	31	previously	previously	ADV
cusj-12940	122	32	established	establish	VERB
cusj-12940	122	33	to	to	PART
cusj-12940	122	34	be	be	AUX
cusj-12940	122	35	a	a	DET
cusj-12940	122	36	good	good	ADJ
cusj-12940	122	37	indicator	indicator	NOUN
cusj-12940	122	38	of	of	ADP
cusj-12940	122	39	the	the	DET
cusj-12940	122	40	likelihood	likelihood	NOUN
cusj-12940	122	41	that	that	SCONJ
cusj-12940	122	42	a	a	DET
cusj-12940	122	43	given	give	VERB
cusj-12940	122	44	protein	protein	NOUN
cusj-12940	122	45	target	target	NOUN
cusj-12940	122	46	of	of	ADP
cusj-12940	122	47	the	the	DET
cusj-12940	122	48	database	database	NOUN
cusj-12940	122	49	ligand	ligand	NOUN
cusj-12940	122	50	is	be	AUX
cusj-12940	122	51	also	also	ADV
cusj-12940	122	52	a	a	DET
cusj-12940	122	53	target	target	NOUN
cusj-12940	122	54	of	of	ADP
cusj-12940	122	55	aebsf	aebsf	ADJ
cusj-12940	122	56	,	,	PUNCT
cusj-12940	122	57	the	the	DET
cusj-12940	122	58	query	query	NOUN
cusj-12940	122	59	ligand	ligand	NOUN
cusj-12940	122	60	(	(	PUNCT
cusj-12940	122	61	fig	fig	NOUN
cusj-12940	122	62	.	.	PUNCT
cusj-12940	122	63	4a	4a	NUM
cusj-12940	122	64	,	,	PUNCT
cusj-12940	122	65	4b	4b	PROPN
cusj-12940	122	66	)	)	PUNCT
cusj-12940	122	67	.	.	PUNCT
cusj-12940	123	1	hence	hence	ADV
cusj-12940	123	2	,	,	PUNCT
cusj-12940	123	3	serine	serine	ADJ
cusj-12940	123	4	protease	protease	NOUN
cusj-12940	123	5	elane	elane	NOUN
cusj-12940	123	6	and	and	CCONJ
cusj-12940	123	7	metalloproteinase	metalloproteinase	PROPN
cusj-12940	123	8	mmp9	mmp9	PROPN
cusj-12940	123	9	expression	expression	NOUN
cusj-12940	123	10	were	be	AUX
cusj-12940	123	11	analyzed	analyze	VERB
cusj-12940	123	12	through	through	ADP
cusj-12940	123	13	indirect	indirect	ADJ
cusj-12940	123	14	elisas	elisa	NOUN
cusj-12940	123	15	.	.	PUNCT
cusj-12940	124	1	both	both	PRON
cusj-12940	124	2	elane	elane	NOUN
cusj-12940	124	3	and	and	CCONJ
cusj-12940	124	4	mmp9	mmp9	VERB
cusj-12940	124	5	protein	protein	NOUN
cusj-12940	124	6	expression	expression	NOUN
cusj-12940	124	7	were	be	AUX
cusj-12940	124	8	demonstrated	demonstrate	VERB
cusj-12940	124	9	to	to	PART
cusj-12940	124	10	decrease	decrease	VERB
cusj-12940	124	11	with	with	ADP
cusj-12940	124	12	increasing	increase	VERB
cusj-12940	124	13	aebsf	aebsf	ADJ
cusj-12940	124	14	concentrations	concentration	NOUN
cusj-12940	124	15	(	(	PUNCT
cusj-12940	124	16	fig	fig	NOUN
cusj-12940	124	17	.	.	PUNCT
cusj-12940	125	1	6a	6a	NOUN
cusj-12940	125	2	,	,	PUNCT
cusj-12940	125	3	6b	6b	NUM
cusj-12940	125	4	)	)	PUNCT
cusj-12940	125	5	.	.	PUNCT
cusj-12940	126	1	columbia	columbia	PROPN
cusj-12940	126	2	undergraduate	undergraduate	PROPN
cusj-12940	126	3	science	science	PROPN
cusj-12940	126	4	journal	journal	PROPN
cusj-12940	126	5	vol	vol	NOUN
cusj-12940	126	6	.	.	PROPN
cusj-12940	127	1	16	16	NUM
cusj-12940	127	2	,	,	PUNCT
cusj-12940	127	3	2022	2022	NUM
cusj-12940	127	4	23	23	NUM
cusj-12940	127	5	figure	figure	NOUN
cusj-12940	127	6	6	6	NUM
cusj-12940	127	7	.	.	PUNCT
cusj-12940	128	1	mmp9	mmp9	PROPN
cusj-12940	128	2	and	and	CCONJ
cusj-12940	128	3	elane	elane	NOUN
cusj-12940	128	4	elisas	elisa	NOUN
cusj-12940	128	5	on	on	ADP
cusj-12940	128	6	t98	t98	NOUN
cusj-12940	128	7	g	g	PROPN
cusj-12940	128	8	cells	cell	NOUN
cusj-12940	128	9	treated	treat	VERB
cusj-12940	128	10	with	with	ADP
cusj-12940	128	11	4	4	NUM
cusj-12940	128	12	-	-	PUNCT
cusj-12940	128	13	benzenesulfonyl	benzenesulfonyl	NOUN
cusj-12940	128	14	fluoride	fluoride	NOUN
cusj-12940	128	15	hydrochloride	hydrochloride	NOUN
cusj-12940	128	16	(	(	PUNCT
cusj-12940	128	17	aebsf	aebsf	ADV
cusj-12940	128	18	)	)	PUNCT
cusj-12940	128	19	.	.	PUNCT
cusj-12940	129	1	bars	bar	NOUN
cusj-12940	129	2	are	be	AUX
cusj-12940	129	3	means	mean	VERB
cusj-12940	129	4	±	±	NUM
cusj-12940	129	5	stdev	stdev	NOUN
cusj-12940	129	6	(	(	PUNCT
cusj-12940	129	7	n=4	n=4	NOUN
cusj-12940	129	8	)	)	PUNCT
cusj-12940	129	9	.	.	PUNCT
cusj-12940	130	1	a	a	DET
cusj-12940	130	2	:	:	PUNCT
cusj-12940	130	3	mmp9	mmp9	PROPN
cusj-12940	130	4	elisa	elisa	PROPN
cusj-12940	130	5	on	on	ADP
cusj-12940	130	6	t98	t98	NOUN
cusj-12940	130	7	g	g	PROPN
cusj-12940	130	8	cells	cell	NOUN
cusj-12940	130	9	treated	treat	VERB
cusj-12940	130	10	with	with	ADP
cusj-12940	130	11	aebsf	aebsf	ADJ
cusj-12940	130	12	for	for	ADP
cusj-12940	130	13	48	48	NUM
cusj-12940	130	14	hours	hour	NOUN
cusj-12940	130	15	.	.	PUNCT
cusj-12940	131	1	48	48	NUM
cusj-12940	131	2	-	-	PUNCT
cusj-12940	131	3	hour	hour	NOUN
cusj-12940	131	4	treatment	treatment	NOUN
cusj-12940	131	5	with	with	ADP
cusj-12940	131	6	aebsf	aebsf	ADJ
cusj-12940	131	7	reduces	reduce	VERB
cusj-12940	131	8	mmp9	mmp9	NOUN
cusj-12940	131	9	protein	protein	NOUN
cusj-12940	131	10	expression	expression	NOUN
cusj-12940	131	11	in	in	ADP
cusj-12940	131	12	t98	t98	PROPN
cusj-12940	131	13	g.	g.	PROPN
cusj-12940	131	14	b	b	PROPN
cusj-12940	131	15	:	:	PUNCT
cusj-12940	131	16	elane	elane	PROPN
cusj-12940	131	17	elisa	elisa	PROPN
cusj-12940	131	18	on	on	ADP
cusj-12940	131	19	t98	t98	NOUN
cusj-12940	131	20	g	g	PROPN
cusj-12940	131	21	cells	cell	NOUN
cusj-12940	131	22	treated	treat	VERB
cusj-12940	131	23	with	with	ADP
cusj-12940	131	24	aebsf	aebsf	ADJ
cusj-12940	131	25	for	for	ADP
cusj-12940	131	26	48	48	NUM
cusj-12940	131	27	hours	hour	NOUN
cusj-12940	131	28	.	.	PUNCT
cusj-12940	132	1	48	48	NUM
cusj-12940	132	2	-	-	PUNCT
cusj-12940	132	3	hour	hour	NOUN
cusj-12940	132	4	treatment	treatment	NOUN
cusj-12940	132	5	with	with	ADP
cusj-12940	132	6	aebsf	aebsf	ADJ
cusj-12940	132	7	reduces	reduce	VERB
cusj-12940	132	8	elane	elane	NOUN
cusj-12940	132	9	protein	protein	NOUN
cusj-12940	132	10	expression	expression	NOUN
cusj-12940	132	11	in	in	ADP
cusj-12940	132	12	t98	t98	PROPN
cusj-12940	132	13	g.	g.	PROPN
cusj-12940	132	14	columbia	columbia	PROPN
cusj-12940	132	15	undergraduate	undergraduate	PROPN
cusj-12940	132	16	science	science	PROPN
cusj-12940	132	17	journal	journal	PROPN
cusj-12940	132	18	vol	vol	NOUN
cusj-12940	132	19	.	.	PROPN
cusj-12940	133	1	16	16	NUM
cusj-12940	133	2	,	,	PUNCT
cusj-12940	133	3	2022	2022	NUM
cusj-12940	133	4	24	24	NUM
cusj-12940	133	5	discussion	discussion	NOUN
cusj-12940	133	6	this	this	DET
cusj-12940	133	7	project	project	NOUN
cusj-12940	133	8	sought	seek	VERB
cusj-12940	133	9	to	to	PART
cusj-12940	133	10	explore	explore	VERB
cusj-12940	133	11	the	the	DET
cusj-12940	133	12	sequence	sequence	NOUN
cusj-12940	133	13	of	of	ADP
cusj-12940	133	14	events	event	NOUN
cusj-12940	133	15	of	of	ADP
cusj-12940	133	16	the	the	DET
cusj-12940	133	17	“	"	PUNCT
cusj-12940	133	18	cascade	cascade	NOUN
cusj-12940	133	19	effect	effect	NOUN
cusj-12940	133	20	”	"	PUNCT
cusj-12940	133	21	perpetuated	perpetuate	VERB
cusj-12940	133	22	by	by	ADP
cusj-12940	133	23	aebsf	aebsf	PROPN
cusj-12940	133	24	in	in	ADP
cusj-12940	133	25	gbm	gbm	PROPN
cusj-12940	133	26	.	.	PUNCT
cusj-12940	134	1	through	through	ADP
cusj-12940	134	2	an	an	DET
cusj-12940	134	3	indirect	indirect	ADJ
cusj-12940	134	4	elisa	elisa	NOUN
cusj-12940	134	5	,	,	PUNCT
cusj-12940	134	6	it	it	PRON
cusj-12940	134	7	was	be	AUX
cusj-12940	134	8	demonstrated	demonstrate	VERB
cusj-12940	134	9	that	that	SCONJ
cusj-12940	134	10	serine	serine	NOUN
cusj-12940	134	11	protease	protease	NOUN
cusj-12940	134	12	inhibitor	inhibitor	NOUN
cusj-12940	134	13	aebsf	aebsf	ADV
cusj-12940	134	14	decreases	decrease	VERB
cusj-12940	134	15	atp6v1a	atp6v1a	VERB
cusj-12940	134	16	expression	expression	NOUN
cusj-12940	134	17	,	,	PUNCT
cusj-12940	134	18	thereby	thereby	ADV
cusj-12940	134	19	activating	activate	VERB
cusj-12940	134	20	elane	elane	NOUN
cusj-12940	134	21	and	and	CCONJ
cusj-12940	134	22	mmp9	mmp9	ADJ
cusj-12940	134	23	proteases	protease	NOUN
cusj-12940	134	24	.	.	PUNCT
cusj-12940	135	1	this	this	PRON
cusj-12940	135	2	,	,	PUNCT
cusj-12940	135	3	in	in	ADP
cusj-12940	135	4	turn	turn	NOUN
cusj-12940	135	5	,	,	PUNCT
cusj-12940	135	6	was	be	AUX
cusj-12940	135	7	indicated	indicate	VERB
cusj-12940	135	8	to	to	PART
cusj-12940	135	9	stimulate	stimulate	VERB
cusj-12940	135	10	ecm	ecm	NOUN
cusj-12940	135	11	degradation	degradation	NOUN
cusj-12940	135	12	and	and	CCONJ
cusj-12940	135	13	overall	overall	ADJ
cusj-12940	135	14	gbm	gbm	PROPN
cusj-12940	135	15	metastasis	metastasis	NOUN
cusj-12940	135	16	and	and	CCONJ
cusj-12940	135	17	migration	migration	NOUN
cusj-12940	135	18	(	(	PUNCT
cusj-12940	135	19	fig	fig	NOUN
cusj-12940	135	20	.	.	PUNCT
cusj-12940	136	1	7	7	NUM
cusj-12940	136	2	)	)	PUNCT
cusj-12940	136	3	.	.	PUNCT
cusj-12940	137	1	it	it	PRON
cusj-12940	137	2	was	be	AUX
cusj-12940	137	3	demonstrated	demonstrate	VERB
cusj-12940	137	4	that	that	SCONJ
cusj-12940	137	5	higher	high	ADJ
cusj-12940	137	6	aebsf	aebsf	ADJ
cusj-12940	137	7	concentrations	concentration	NOUN
cusj-12940	137	8	had	have	VERB
cusj-12940	137	9	a	a	DET
cusj-12940	137	10	greater	great	ADJ
cusj-12940	137	11	effect	effect	NOUN
cusj-12940	137	12	on	on	ADP
cusj-12940	137	13	the	the	DET
cusj-12940	137	14	studied	study	VERB
cusj-12940	137	15	parameters	parameter	NOUN
cusj-12940	137	16	.	.	PUNCT
cusj-12940	138	1	however	however	ADV
cusj-12940	138	2	,	,	PUNCT
cusj-12940	138	3	the	the	DET
cusj-12940	138	4	optimal	optimal	ADJ
cusj-12940	138	5	aebsf	aebsf	ADJ
cusj-12940	138	6	dosage	dosage	NOUN
cusj-12940	138	7	remains	remain	VERB
cusj-12940	138	8	to	to	PART
cusj-12940	138	9	be	be	AUX
cusj-12940	138	10	determined	determine	VERB
cusj-12940	138	11	and	and	CCONJ
cusj-12940	138	12	will	will	AUX
cusj-12940	138	13	be	be	AUX
cusj-12940	138	14	studied	study	VERB
cusj-12940	138	15	in	in	ADP
cusj-12940	138	16	the	the	DET
cusj-12940	138	17	future	future	NOUN
cusj-12940	138	18	.	.	PUNCT
cusj-12940	139	1	in	in	ADP
cusj-12940	139	2	the	the	DET
cusj-12940	139	3	future	future	NOUN
cusj-12940	139	4	,	,	PUNCT
cusj-12940	139	5	the	the	DET
cusj-12940	139	6	mechanisms	mechanism	NOUN
cusj-12940	139	7	of	of	ADP
cusj-12940	139	8	elane	elane	NOUN
cusj-12940	139	9	and	and	CCONJ
cusj-12940	139	10	mmp9	mmp9	ADV
cusj-12940	139	11	-	-	PUNCT
cusj-12940	139	12	mediated	mediate	VERB
cusj-12940	139	13	ecm	ecm	NOUN
cusj-12940	139	14	disassembly	disassembly	ADV
cusj-12940	139	15	will	will	AUX
cusj-12940	139	16	be	be	AUX
cusj-12940	139	17	studied	study	VERB
cusj-12940	139	18	.	.	PUNCT
cusj-12940	140	1	this	this	PRON
cusj-12940	140	2	may	may	AUX
cusj-12940	140	3	give	give	VERB
cusj-12940	140	4	greater	great	ADJ
cusj-12940	140	5	insight	insight	NOUN
cusj-12940	140	6	into	into	ADP
cusj-12940	140	7	these	these	DET
cusj-12940	140	8	proteases	protease	NOUN
cusj-12940	140	9	’	'	PUNCT
cusj-12940	140	10	mechanisms	mechanism	NOUN
cusj-12940	140	11	of	of	ADP
cusj-12940	140	12	action	action	NOUN
cusj-12940	140	13	,	,	PUNCT
cusj-12940	140	14	and	and	CCONJ
cusj-12940	140	15	possibly	possibly	ADV
cusj-12940	140	16	further	far	ADV
cusj-12940	140	17	clarify	clarify	VERB
cusj-12940	140	18	the	the	DET
cusj-12940	140	19	link	link	NOUN
cusj-12940	140	20	between	between	ADP
cusj-12940	140	21	ecm	ecm	NOUN
cusj-12940	140	22	disassembly	disassembly	ADV
cusj-12940	140	23	and	and	CCONJ
cusj-12940	140	24	gbm	gbm	PROPN
cusj-12940	140	25	metastasis	metastasis	NOUN
cusj-12940	140	26	.	.	PUNCT
cusj-12940	141	1	the	the	DET
cusj-12940	141	2	findings	finding	NOUN
cusj-12940	141	3	in	in	ADP
cusj-12940	141	4	this	this	DET
cusj-12940	141	5	study	study	NOUN
cusj-12940	141	6	may	may	AUX
cusj-12940	141	7	provide	provide	VERB
cusj-12940	141	8	more	more	ADJ
cusj-12940	141	9	insight	insight	NOUN
cusj-12940	141	10	into	into	ADP
cusj-12940	141	11	the	the	DET
cusj-12940	141	12	mechanics	mechanic	NOUN
cusj-12940	141	13	of	of	ADP
cusj-12940	141	14	gbm	gbm	PROPN
cusj-12940	141	15	metastasis	metastasis	NOUN
cusj-12940	141	16	,	,	PUNCT
cusj-12940	141	17	highlighting	highlight	VERB
cusj-12940	141	18	the	the	DET
cusj-12940	141	19	role	role	NOUN
cusj-12940	141	20	of	of	ADP
cusj-12940	141	21	serine	serine	NOUN
cusj-12940	141	22	proteases	protease	NOUN
cusj-12940	141	23	and	and	CCONJ
cusj-12940	141	24	tumor	tumor	NOUN
cusj-12940	141	25	metastasis	metastasis	NOUN
cusj-12940	141	26	.	.	PUNCT
cusj-12940	142	1	author	author	NOUN
cusj-12940	142	2	information	information	NOUN
cusj-12940	142	3	corresponding	correspond	VERB
cusj-12940	142	4	author	author	NOUN
cusj-12940	142	5	*	*	PUNCT
cusj-12940	142	6	mehwish	mehwish	PROPN
cusj-12940	142	7	mirza	mirza	PROPN
cusj-12940	142	8	(	(	PUNCT
cusj-12940	142	9	academy	academy	NOUN
cusj-12940	142	10	for	for	ADP
cusj-12940	142	11	medical	medical	ADJ
cusj-12940	142	12	science	science	NOUN
cusj-12940	142	13	technology	technology	NOUN
cusj-12940	142	14	,	,	PUNCT
cusj-12940	142	15	department	department	NOUN
cusj-12940	142	16	of	of	ADP
cusj-12940	142	17	cellular	cellular	ADJ
cusj-12940	142	18	biology	biology	NOUN
cusj-12940	142	19	research	research	NOUN
cusj-12940	142	20	,	,	PUNCT
cusj-12940	142	21	bergen	bergen	PROPN
cusj-12940	142	22	county	county	PROPN
cusj-12940	142	23	academies	academy	NOUN
cusj-12940	142	24	,	,	PUNCT
cusj-12940	142	25	hackensack	hackensack	PROPN
cusj-12940	142	26	,	,	PUNCT
cusj-12940	142	27	nj	nj	PROPN
cusj-12940	142	28	,	,	PUNCT
cusj-12940	142	29	usa	usa	PROPN
cusj-12940	142	30	)	)	PUNCT
cusj-12940	142	31	mehwish.mirza05@gmail.com	mehwish.mirza05@gmail.com	PART
cusj-12940	143	1	author	author	NOUN
cusj-12940	143	2	contributions	contribution	VERB
cusj-12940	143	3	mehwish	mehwish	PROPN
cusj-12940	143	4	mirza	mirza	PROPN
cusj-12940	143	5	performed	perform	VERB
cusj-12940	143	6	the	the	DET
cusj-12940	143	7	data	datum	NOUN
cusj-12940	143	8	analysis	analysis	NOUN
cusj-12940	143	9	and	and	CCONJ
cusj-12940	143	10	produced	produce	VERB
cusj-12940	143	11	the	the	DET
cusj-12940	143	12	figures	figure	NOUN
cusj-12940	143	13	and	and	CCONJ
cusj-12940	143	14	manuscript	manuscript	NOUN
cusj-12940	143	15	.	.	PUNCT
cusj-12940	144	1	dr	dr	PROPN
cusj-12940	144	2	.	.	PROPN
cusj-12940	144	3	german	german	PROPN
cusj-12940	144	4	sabio	sabio	PROPN
cusj-12940	144	5	provided	provide	VERB
cusj-12940	144	6	technical	technical	ADJ
cusj-12940	144	7	assistance	assistance	NOUN
cusj-12940	144	8	with	with	ADP
cusj-12940	144	9	analysis	analysis	NOUN
cusj-12940	144	10	and	and	CCONJ
cusj-12940	144	11	pipelines	pipeline	NOUN
cusj-12940	144	12	.	.	PUNCT
cusj-12940	145	1	dr	dr	PROPN
cusj-12940	145	2	.	.	PROPN
cusj-12940	145	3	german	german	PROPN
cusj-12940	145	4	sabio	sabio	PROPN
cusj-12940	145	5	and	and	CCONJ
cusj-12940	145	6	donna	donna	PROPN
cusj-12940	145	7	leonardi	leonardi	PROPN
cusj-12940	145	8	added	add	VERB
cusj-12940	145	9	project	project	NOUN
cusj-12940	145	10	direction	direction	NOUN
cusj-12940	145	11	and	and	CCONJ
cusj-12940	145	12	provided	provide	VERB
cusj-12940	145	13	guidance	guidance	NOUN
cusj-12940	145	14	.	.	PUNCT
cusj-12940	146	1	elisa	elisa	PROPN
cusj-12940	146	2	huang	huang	PROPN
cusj-12940	146	3	and	and	CCONJ
cusj-12940	146	4	christine	christine	PROPN
cusj-12940	146	5	chow	chow	PROPN
cusj-12940	146	6	provided	provide	VERB
cusj-12940	146	7	expert	expert	NOUN
cusj-12940	146	8	feedback	feedback	NOUN
cusj-12940	146	9	for	for	ADP
cusj-12940	146	10	the	the	DET
cusj-12940	146	11	project	project	NOUN
cusj-12940	146	12	.	.	PUNCT
cusj-12940	147	1	competing	compete	VERB
cusj-12940	147	2	interests	interest	NOUN
cusj-12940	147	3	the	the	DET
cusj-12940	147	4	authors	author	NOUN
cusj-12940	147	5	declare	declare	VERB
cusj-12940	147	6	no	no	DET
cusj-12940	147	7	competing	compete	VERB
cusj-12940	147	8	financial	financial	ADJ
cusj-12940	147	9	and	and	CCONJ
cusj-12940	147	10	non	non	ADJ
cusj-12940	147	11	-	-	ADJ
cusj-12940	147	12	financial	financial	ADJ
cusj-12940	147	13	interests	interest	NOUN
cusj-12940	147	14	.	.	PUNCT
cusj-12940	148	1	references	reference	NOUN
cusj-12940	148	2	[	[	X
cusj-12940	148	3	1	1	NUM
cusj-12940	148	4	]	]	X
cusj-12940	148	5	tamimi	tamimi	PROPN
cusj-12940	148	6	af	af	PROPN
cusj-12940	148	7	,	,	PUNCT
cusj-12940	148	8	juweid	juweid	NOUN
cusj-12940	148	9	m.	m.	NOUN
cusj-12940	148	10	epidemiology	epidemiology	NOUN
cusj-12940	148	11	and	and	CCONJ
cusj-12940	148	12	outcome	outcome	NOUN
cusj-12940	148	13	of	of	ADP
cusj-12940	148	14	glioblastoma	glioblastoma	NOUN
cusj-12940	148	15	.	.	PUNCT
cusj-12940	149	1	in	in	ADP
cusj-12940	149	2	:	:	PUNCT
cusj-12940	149	3	de	de	X
cusj-12940	149	4	vleeschouwer	vleeschouwer	PROPN
cusj-12940	149	5	s	s	PROPN
cusj-12940	149	6	,	,	PUNCT
cusj-12940	149	7	editor	editor	NOUN
cusj-12940	149	8	.	.	PUNCT
cusj-12940	150	1	glioblastoma	glioblastoma	NOUN
cusj-12940	151	1	[	[	X
cusj-12940	151	2	internet	internet	NOUN
cusj-12940	151	3	]	]	PUNCT
cusj-12940	151	4	.	.	PUNCT
cusj-12940	152	1	brisbane	brisbane	PROPN
cusj-12940	152	2	(	(	PUNCT
cusj-12940	152	3	au	au	PROPN
cusj-12940	152	4	):	):	PUNCT
cusj-12940	152	5	codon	codon	ADJ
cusj-12940	152	6	publications	publication	NOUN
cusj-12940	152	7	;	;	PUNCT
cusj-12940	152	8	2017	2017	NUM
cusj-12940	152	9	sep	sep	NOUN
cusj-12940	152	10	27	27	NUM
cusj-12940	152	11	.	.	PUNCT
cusj-12940	153	1	chapter	chapter	NOUN
cusj-12940	153	2	8	8	NUM
cusj-12940	153	3	.	.	PUNCT
cusj-12940	153	4	doi	doi	NOUN
cusj-12940	153	5	:	:	PUNCT
cusj-12940	153	6	10.15586	10.15586	NUM
cusj-12940	153	7	/	/	SYM
cusj-12940	153	8	codon.glioblastoma.2017	codon.glioblastoma.2017	NOUN
cusj-12940	153	9	.	.	PUNCT
cusj-12940	153	10	ch8	ch8	PROPN
cusj-12940	153	11	.	.	PUNCT
cusj-12940	154	1	https://www.ncbi.nlm.nih.gov/books/	https://www.ncbi.nlm.nih.gov/books/	PROPN
cusj-12940	154	2	nbk470003/	nbk470003/	ADV
cusj-12940	154	3	[	[	X
cusj-12940	154	4	2	2	NUM
cusj-12940	154	5	]	]	X
cusj-12940	154	6	kato	kato	PROPN
cusj-12940	154	7	,	,	PUNCT
cusj-12940	154	8	y.	y.	PROPN
cusj-12940	154	9	,	,	PUNCT
cusj-12940	154	10	ozawa	ozawa	PROPN
cusj-12940	154	11	,	,	PUNCT
cusj-12940	154	12	s.	s.	PROPN
cusj-12940	154	13	,	,	PUNCT
cusj-12940	154	14	miyamoto	miyamoto	NOUN
cusj-12940	154	15	,	,	PUNCT
cusj-12940	154	16	c.	c.	PROPN
cusj-12940	154	17	,	,	PUNCT
cusj-12940	154	18	maehata	maehata	PROPN
cusj-12940	154	19	,	,	PUNCT
cusj-12940	154	20	y.	y.	PROPN
cusj-12940	154	21	,	,	PUNCT
cusj-12940	154	22	suzuki	suzuki	PROPN
cusj-12940	154	23	,	,	PUNCT
cusj-12940	154	24	a.	a.	PROPN
cusj-12940	154	25	,	,	PUNCT
cusj-12940	154	26	maeda	maeda	PROPN
cusj-12940	154	27	,	,	PUNCT
cusj-12940	154	28	t.	t.	PROPN
cusj-12940	154	29	,	,	PUNCT
cusj-12940	154	30	&	&	CCONJ
cusj-12940	154	31	baba	baba	PROPN
cusj-12940	154	32	,	,	PUNCT
cusj-12940	154	33	y.	y.	PROPN
cusj-12940	154	34	(	(	PUNCT
cusj-12940	154	35	2013	2013	NUM
cusj-12940	154	36	)	)	PUNCT
cusj-12940	154	37	.	.	PUNCT
cusj-12940	155	1	acidic	acidic	ADJ
cusj-12940	155	2	extracellular	extracellular	ADJ
cusj-12940	155	3	microenvironment	microenvironment	NOUN
cusj-12940	155	4	and	and	CCONJ
cusj-12940	155	5	cancer	cancer	NOUN
cusj-12940	155	6	.	.	PUNCT
cusj-12940	156	1	cancer	cancer	NOUN
cusj-12940	156	2	cell	cell	NOUN
cusj-12940	156	3	international	international	PROPN
cusj-12940	156	4	,	,	PUNCT
cusj-12940	156	5	13(1	13(1	NUM
cusj-12940	156	6	)	)	PUNCT
cusj-12940	156	7	,	,	PUNCT
cusj-12940	156	8	89	89	NUM
cusj-12940	156	9	.	.	PUNCT
cusj-12940	157	1	doi	doi	NOUN
cusj-12940	157	2	:	:	PUNCT
cusj-12940	157	3	10.1186/1475	10.1186/1475	NUM
cusj-12940	157	4	-	-	SYM
cusj-12940	157	5	2867	2867	NUM
cusj-12940	157	6	-	-	SYM
cusj-12940	157	7	13	13	NUM
cusj-12940	157	8	-	-	SYM
cusj-12940	157	9	89	89	NUM
cusj-12940	157	10	.	.	PUNCT
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cusj-12940	158	1	[	[	X
cusj-12940	158	2	3	3	NUM
cusj-12940	158	3	]	]	PUNCT
cusj-12940	158	4	ward	ward	NOUN
cusj-12940	158	5	c	c	NOUN
cusj-12940	158	6	,	,	PUNCT
cusj-12940	158	7	meehan	meehan	PROPN
cusj-12940	158	8	j	j	PROPN
cusj-12940	158	9	,	,	PUNCT
cusj-12940	158	10	gray	gray	VERB
cusj-12940	158	11	me	i	PRON
cusj-12940	158	12	,	,	PUNCT
cusj-12940	158	13	murray	murray	PROPN
cusj-12940	158	14	af	af	PROPN
cusj-12940	158	15	,	,	PUNCT
cusj-12940	158	16	argyle	argyle	PROPN
cusj-12940	158	17	dj	dj	PROPN
cusj-12940	158	18	,	,	PUNCT
cusj-12940	158	19	kunkler	kunkler	PROPN
cusj-12940	158	20	ih	ih	PROPN
cusj-12940	158	21	,	,	PUNCT
cusj-12940	158	22	et	et	PROPN
cusj-12940	158	23	al	al	PROPN
cusj-12940	158	24	.	.	PUNCT
cusj-12940	159	1	the	the	DET
cusj-12940	159	2	impact	impact	NOUN
cusj-12940	159	3	of	of	ADP
cusj-12940	159	4	tumour	tumour	NOUN
cusj-12940	159	5	ph	ph	NOUN
cusj-12940	159	6	on	on	ADP
cusj-12940	159	7	cancer	cancer	NOUN
cusj-12940	159	8	progression	progression	NOUN
cusj-12940	159	9	:	:	PUNCT
cusj-12940	159	10	strategies	strategy	NOUN
cusj-12940	159	11	for	for	ADP
cusj-12940	159	12	clinical	clinical	ADJ
cusj-12940	159	13	intervention	intervention	NOUN
cusj-12940	159	14	.	.	PUNCT
cusj-12940	160	1	explor	explor	NOUN
cusj-12940	160	2	target	target	NOUN
cusj-12940	160	3	antitumor	antitumor	PROPN
cusj-12940	160	4	ther	ther	ADV
cusj-12940	160	5	.	.	PUNCT
cusj-12940	161	1	2020;1:71	2020;1:71	PROPN
cusj-12940	161	2	-	-	PUNCT
cusj-12940	161	3	100	100	NUM
cusj-12940	161	4	.	.	PUNCT
cusj-12940	162	1	doi	doi	NOUN
cusj-12940	162	2	:	:	PUNCT
cusj-12940	162	3	10.37349/	10.37349/	NUM
cusj-12940	162	4	etat.2020.00005	etat.2020.00005	NUM
cusj-12940	162	5	.	.	PUNCT
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cusj-12940	163	2	.	.	PUNCT
cusj-12940	163	3	com	com	NOUN
cusj-12940	163	4	/	/	SYM
cusj-12940	163	5	journals	journal	NOUN
cusj-12940	163	6	/	/	SYM
cusj-12940	163	7	etat	etat	PROPN
cusj-12940	163	8	/	/	SYM
cusj-12940	163	9	article/10025	article/10025	NOUN
cusj-12940	163	10	[	[	X
cusj-12940	163	11	4	4	NUM
cusj-12940	163	12	]	]	X
cusj-12940	163	13	park	park	NOUN
cusj-12940	163	14	,	,	PUNCT
cusj-12940	163	15	k.	k.	PROPN
cusj-12940	163	16	c.	c.	PROPN
cusj-12940	163	17	,	,	PUNCT
cusj-12940	163	18	dharmasivam	dharmasivam	NOUN
cusj-12940	163	19	,	,	PUNCT
cusj-12940	163	20	m.	m.	NOUN
cusj-12940	163	21	,	,	PUNCT
cusj-12940	163	22	&	&	CCONJ
cusj-12940	163	23	richardson	richardson	PROPN
cusj-12940	163	24	,	,	PUNCT
cusj-12940	163	25	d.	d.	PROPN
cusj-12940	163	26	r.	r.	PROPN
cusj-12940	163	27	(	(	PUNCT
cusj-12940	163	28	2020	2020	NUM
cusj-12940	163	29	)	)	PUNCT
cusj-12940	163	30	.	.	PUNCT
cusj-12940	164	1	the	the	DET
cusj-12940	164	2	role	role	NOUN
cusj-12940	164	3	of	of	ADP
cusj-12940	164	4	extracellular	extracellular	ADJ
cusj-12940	164	5	proteases	protease	NOUN
cusj-12940	164	6	in	in	ADP
cusj-12940	164	7	tumor	tumor	NOUN
cusj-12940	164	8	progression	progression	NOUN
cusj-12940	164	9	and	and	CCONJ
cusj-12940	164	10	the	the	DET
cusj-12940	164	11	development	development	NOUN
cusj-12940	164	12	of	of	ADP
cusj-12940	164	13	innovative	innovative	ADJ
cusj-12940	164	14	metal	metal	NOUN
cusj-12940	164	15	ion	ion	NOUN
cusj-12940	164	16	chelators	chelator	NOUN
cusj-12940	164	17	that	that	PRON
cusj-12940	164	18	inhibit	inhibit	VERB
cusj-12940	164	19	their	their	PRON
cusj-12940	164	20	activity	activity	NOUN
cusj-12940	164	21	.	.	PUNCT
cusj-12940	165	1	international	international	ADJ
cusj-12940	165	2	journal	journal	NOUN
cusj-12940	165	3	of	of	ADP
cusj-12940	165	4	molecular	molecular	ADJ
cusj-12940	165	5	sciences	science	NOUN
cusj-12940	165	6	,	,	PUNCT
cusj-12940	165	7	21(18	21(18	NUM
cusj-12940	165	8	)	)	PUNCT
cusj-12940	165	9	,	,	PUNCT
cusj-12940	165	10	6805	6805	NUM
cusj-12940	165	11	.	.	PUNCT
cusj-12940	166	1	doi	doi	NOUN
cusj-12940	166	2	:	:	PUNCT
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cusj-12940	166	4	/	/	SYM
cusj-12940	166	5	ijms21186805	ijms21186805	PROPN
cusj-12940	166	6	.	.	PUNCT
cusj-12940	167	1	https://www.ncbi.nlm	https://www.ncbi.nlm	X
cusj-12940	167	2	.	.	PUNCT
cusj-12940	168	1	nih.gov/pmc/articles/pmc7555822/	nih.gov/pmc/articles/pmc7555822/	PROPN
cusj-12940	169	1	[	[	X
cusj-12940	169	2	5	5	NUM
cusj-12940	169	3	]	]	PUNCT
cusj-12940	169	4	l.	l.	PROPN
cusj-12940	169	5	shannon	shannon	PROPN
cusj-12940	169	6	holliday	holliday	PROPN
cusj-12940	169	7	,	,	PUNCT
cusj-12940	169	8	"	"	PUNCT
cusj-12940	169	9	vacuolar	vacuolar	ADJ
cusj-12940	169	10	h+-atpase	h+-atpase	NOUN
cusj-12940	169	11	:	:	PUNCT
cusj-12940	169	12	an	an	DET
cusj-12940	169	13	essential	essential	ADJ
cusj-12940	169	14	multitasking	multitaske	VERB
cusj-12940	169	15	enzyme	enzyme	NOUN
cusj-12940	169	16	in	in	ADP
cusj-12940	169	17	physiology	physiology	NOUN
cusj-12940	169	18	and	and	CCONJ
cusj-12940	169	19	pathophysiology	pathophysiology	NOUN
cusj-12940	169	20	"	"	PUNCT
cusj-12940	169	21	,	,	PUNCT
cusj-12940	169	22	new	new	ADJ
cusj-12940	169	23	journal	journal	NOUN
cusj-12940	169	24	of	of	ADP
cusj-12940	169	25	science	science	NOUN
cusj-12940	169	26	,	,	PUNCT
cusj-12940	169	27	vol	vol	NOUN
cusj-12940	169	28	.	.	PROPN
cusj-12940	169	29	2014	2014	NUM
cusj-12940	169	30	,	,	PUNCT
cusj-12940	169	31	article	article	NOUN
cusj-12940	169	32	i	i	PROPN
cusj-12940	169	33	d	d	PROPN
cusj-12940	169	34	675430	675430	NUM
cusj-12940	169	35	,	,	PUNCT
cusj-12940	169	36	21	21	NUM
cusj-12940	169	37	pages	page	NOUN
cusj-12940	169	38	,	,	PUNCT
cusj-12940	169	39	2014	2014	NUM
cusj-12940	169	40	.	.	PUNCT
cusj-12940	170	1	doi	doi	NOUN
cusj-12940	170	2	:	:	PUNCT
cusj-12940	170	3	10.1155/2014/675430	10.1155/2014/675430	NUM
cusj-12940	170	4	.	.	PUNCT
cusj-12940	171	1	https://downcolumbia	https://downcolumbia	PRON
cusj-12940	171	2	undergraduate	undergraduate	NOUN
cusj-12940	171	3	science	science	PROPN
cusj-12940	171	4	journal	journal	PROPN
cusj-12940	171	5	vol	vol	NOUN
cusj-12940	171	6	.	.	PROPN
cusj-12940	172	1	16	16	NUM
cusj-12940	172	2	,	,	PUNCT
cusj-12940	172	3	2022	2022	NUM
cusj-12940	172	4	25	25	NUM
cusj-12940	172	5	[	[	SYM
cusj-12940	172	6	6	6	NUM
cusj-12940	172	7	]	]	X
cusj-12940	172	8	cotter	cotter	PROPN
cusj-12940	172	9	,	,	PUNCT
cusj-12940	172	10	k.	k.	PROPN
cusj-12940	172	11	,	,	PUNCT
cusj-12940	172	12	capecci	capecci	PROPN
cusj-12940	172	13	,	,	PUNCT
cusj-12940	172	14	j.	j.	PROPN
cusj-12940	172	15	,	,	PUNCT
cusj-12940	172	16	sennoune	sennoune	PROPN
cusj-12940	172	17	,	,	PUNCT
cusj-12940	172	18	s.	s.	PROPN
cusj-12940	172	19	,	,	PUNCT
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cusj-12940	172	21	,	,	PUNCT
cusj-12940	172	22	m.	m.	NOUN
cusj-12940	172	23	,	,	PUNCT
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cusj-12940	172	25	,	,	PUNCT
cusj-12940	172	26	m.	m.	NOUN
cusj-12940	172	27	,	,	PUNCT
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cusj-12940	172	29	-	-	PUNCT
cusj-12940	172	30	zaguilan	zaguilan	PROPN
cusj-12940	172	31	,	,	PUNCT
cusj-12940	172	32	r.	r.	PROPN
cusj-12940	172	33	,	,	PUNCT
cusj-12940	172	34	&	&	CCONJ
cusj-12940	172	35	forgac	forgac	PROPN
cusj-12940	172	36	,	,	PUNCT
cusj-12940	172	37	m.	m.	NOUN
cusj-12940	172	38	(	(	PUNCT
cusj-12940	172	39	2015	2015	NUM
cusj-12940	172	40	)	)	PUNCT
cusj-12940	172	41	.	.	PUNCT
cusj-12940	173	1	activity	activity	NOUN
cusj-12940	173	2	of	of	ADP
cusj-12940	173	3	plasma	plasma	NOUN
cusj-12940	173	4	membrane	membrane	NOUN
cusj-12940	173	5	v	v	NOUN
cusj-12940	173	6	-	-	PUNCT
cusj-12940	173	7	atpases	atpase	NOUN
cusj-12940	173	8	is	be	AUX
cusj-12940	173	9	critical	critical	ADJ
cusj-12940	173	10	for	for	ADP
cusj-12940	173	11	the	the	DET
cusj-12940	173	12	invasion	invasion	NOUN
cusj-12940	173	13	of	of	ADP
cusj-12940	173	14	mdamb231	mdamb231	PROPN
cusj-12940	173	15	breast	breast	NOUN
cusj-12940	173	16	cancer	cancer	NOUN
cusj-12940	173	17	cells	cell	NOUN
cusj-12940	173	18	.	.	PUNCT
cusj-12940	174	1	the	the	DET
cusj-12940	174	2	journal	journal	NOUN
cusj-12940	174	3	of	of	ADP
cusj-12940	174	4	biological	biological	ADJ
cusj-12940	174	5	chemistry	chemistry	NOUN
cusj-12940	174	6	,	,	PUNCT
cusj-12940	174	7	290(6	290(6	NUM
cusj-12940	174	8	)	)	PUNCT
cusj-12940	174	9	,	,	PUNCT
cusj-12940	174	10	3680–3692	3680–3692	NUM
cusj-12940	174	11	.	.	PUNCT
cusj-12940	175	1	doi	doi	NOUN
cusj-12940	175	2	:	:	PUNCT
cusj-12940	175	3	10.1074	10.1074	NUM
cusj-12940	175	4	/	/	SYM
cusj-12940	175	5	jbc.m114.611210	jbc.m114.611210	NOUN
cusj-12940	175	6	.	.	PUNCT
cusj-12940	176	1	https://www.ncbi	https://www.ncbi	PROPN
cusj-12940	176	2	.	.	PUNCT
cusj-12940	177	1	nlm.nih.gov/pmc/articles/pmc4319033/	nlm.nih.gov/pmc/articles/pmc4319033/	PRON
cusj-12940	178	1	[	[	X
cusj-12940	178	2	7	7	X
cusj-12940	178	3	]	]	X
cusj-12940	178	4	jiayu	jiayu	PROPN
cusj-12940	178	5	gong	gong	PROPN
cusj-12940	178	6	,	,	PUNCT
cusj-12940	178	7	chaoqian	chaoqian	PROPN
cusj-12940	178	8	cai	cai	PROPN
cusj-12940	178	9	,	,	PUNCT
cusj-12940	178	10	xiaofeng	xiaofeng	PROPN
cusj-12940	178	11	liu	liu	PROPN
cusj-12940	178	12	,	,	PUNCT
cusj-12940	178	13	xin	xin	PROPN
cusj-12940	178	14	ku	ku	PROPN
cusj-12940	178	15	,	,	PUNCT
cusj-12940	178	16	hualiang	hualiang	PROPN
cusj-12940	178	17	jiang	jiang	PROPN
cusj-12940	178	18	,	,	PUNCT
cusj-12940	178	19	daqi	daqi	PROPN
cusj-12940	178	20	gao	gao	PROPN
cusj-12940	178	21	and	and	CCONJ
cusj-12940	178	22	honglin	honglin	PROPN
cusj-12940	178	23	li	li	PROPN
cusj-12940	178	24	.	.	PROPN
cusj-12940	178	25	chemmapper	chemmapper	PROPN
cusj-12940	178	26	:	:	PUNCT
cusj-12940	178	27	a	a	DET
cusj-12940	178	28	versatile	versatile	ADJ
cusj-12940	178	29	web	web	NOUN
cusj-12940	178	30	server	server	NOUN
cusj-12940	178	31	for	for	ADP
cusj-12940	178	32	exploring	explore	VERB
cusj-12940	178	33	pharmacology	pharmacology	NOUN
cusj-12940	178	34	and	and	CCONJ
cusj-12940	178	35	chemical	chemical	NOUN
cusj-12940	178	36	structure	structure	NOUN
cusj-12940	178	37	association	association	NOUN
cusj-12940	178	38	based	base	VERB
cusj-12940	178	39	on	on	ADP
cusj-12940	178	40	molecular	molecular	ADJ
cusj-12940	178	41	3d	3d	PROPN
cusj-12940	178	42	similarity	similarity	NOUN
cusj-12940	178	43	method	method	NOUN
cusj-12940	178	44	.	.	PUNCT
cusj-12940	179	1	bioinformatics	bioinformatics	NOUN
cusj-12940	179	2	.	.	PUNCT
cusj-12940	180	1	2013	2013	NUM
cusj-12940	180	2	,	,	PUNCT
cusj-12940	180	3	29	29	NUM
cusj-12940	180	4	(	(	PUNCT
cusj-12940	180	5	14	14	NUM
cusj-12940	180	6	)	)	PUNCT
cusj-12940	180	7	,	,	PUNCT
cusj-12940	180	8	1827	1827	NUM
cusj-12940	180	9	-	-	SYM
cusj-12940	180	10	1829	1829	NUM
cusj-12940	180	11	.	.	PUNCT
cusj-12940	181	1	https://pubmed.ncbi.nlm.nih	https://pubmed.ncbi.nlm.nih	PROPN
cusj-12940	181	2	.	.	PUNCT
cusj-12940	182	1	gov/23712658/	gov/23712658/	PROPN
cusj-12940	182	2	[	[	X
cusj-12940	182	3	8	8	NUM
cusj-12940	182	4	]	]	PUNCT
cusj-12940	182	5	xiaofeng	xiaofeng	PROPN
cusj-12940	182	6	liu	liu	PROPN
cusj-12940	182	7	,	,	PUNCT
cusj-12940	182	8	hualiang	hualiang	PROPN
cusj-12940	182	9	jiang	jiang	PROPN
cusj-12940	182	10	,	,	PUNCT
cusj-12940	182	11	honglin	honglin	PROPN
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cusj-12940	182	13	.	.	PROPN
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cusj-12940	183	2	:	:	PUNCT
cusj-12940	183	3	a	a	DET
cusj-12940	183	4	hybrid	hybrid	ADJ
cusj-12940	183	5	approach	approach	NOUN
cusj-12940	183	6	for	for	ADP
cusj-12940	183	7	3d	3d	NUM
cusj-12940	183	8	molecular	molecular	ADJ
cusj-12940	183	9	similarity	similarity	NOUN
cusj-12940	183	10	calculation	calculation	NOUN
cusj-12940	183	11	.	.	PUNCT
cusj-12940	184	1	1	1	X
cusj-12940	184	2	.	.	X
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cusj-12940	184	4	and	and	CCONJ
cusj-12940	184	5	assessment	assessment	NOUN
cusj-12940	184	6	of	of	ADP
cusj-12940	184	7	virtual	virtual	ADJ
cusj-12940	184	8	screening	screening	NOUN
cusj-12940	184	9	.	.	PUNCT
cusj-12940	185	1	j.	j.	PROPN
cusj-12940	185	2	chem	chem	PROPN
cusj-12940	185	3	.	.	PUNCT
cusj-12940	186	1	inf	inf	PROPN
cusj-12940	186	2	.	.	PROPN
cusj-12940	186	3	model	model	PROPN
cusj-12940	186	4	.	.	PUNCT
cusj-12940	187	1	2011	2011	NUM
cusj-12940	187	2	,	,	PUNCT
cusj-12940	187	3	51	51	NUM
cusj-12940	187	4	(	(	PUNCT
cusj-12940	187	5	9	9	NUM
cusj-12940	187	6	)	)	PUNCT
cusj-12940	187	7	,	,	PUNCT
cusj-12940	187	8	2372	2372	NUM
cusj-12940	187	9	-	-	SYM
cusj-12940	187	10	2385	2385	NUM
cusj-12940	187	11	.	.	PUNCT
cusj-12940	188	1	https://pubs.acs.org/	https://pubs.acs.org/	PROPN
cusj-12940	188	2	doi	doi	PROPN
cusj-12940	188	3	/	/	SYM
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cusj-12940	188	5	/	/	SYM
cusj-12940	188	6	ci200060s	ci200060s	PROPN
cusj-12940	189	1	[	[	X
cusj-12940	189	2	9	9	X
cusj-12940	189	3	]	]	X
cusj-12940	189	4	weiqiang	weiqiang	PROPN
cusj-12940	189	5	lu	lu	PROPN
cusj-12940	189	6	,	,	PUNCT
cusj-12940	189	7	xiaofeng	xiaofeng	PROPN
cusj-12940	189	8	liu	liu	PROPN
cusj-12940	189	9	,	,	PUNCT
cusj-12940	189	10	xianwen	xianwen	PROPN
cusj-12940	189	11	cao	cao	PROPN
cusj-12940	189	12	,	,	PUNCT
cusj-12940	189	13	mengzhu	mengzhu	PROPN
cusj-12940	189	14	xue	xue	PROPN
cusj-12940	189	15	,	,	PUNCT
cusj-12940	189	16	kangdong	kangdong	PROPN
cusj-12940	189	17	liu	liu	PROPN
cusj-12940	189	18	,	,	PUNCT
cusj-12940	189	19	zhenjiang	zhenjiang	PROPN
cusj-12940	189	20	zhao	zhao	PROPN
cusj-12940	189	21	,	,	PUNCT
cusj-12940	189	22	xu	xu	PROPN
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cusj-12940	189	24	,	,	PUNCT
cusj-12940	189	25	hualiang	hualiang	PROPN
cusj-12940	189	26	jiang	jiang	PROPN
cusj-12940	189	27	,	,	PUNCT
cusj-12940	189	28	yufang	yufang	PROPN
cusj-12940	189	29	xu	xu	PROPN
cusj-12940	189	30	,	,	PUNCT
cusj-12940	189	31	jin	jin	PROPN
cusj-12940	189	32	huang	huang	PROPN
cusj-12940	189	33	and	and	CCONJ
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cusj-12940	189	35	li	li	PROPN
cusj-12940	189	36	.	.	PROPN
cusj-12940	189	37	shafts	shafts	ADJ
cusj-12940	189	38	:	:	PUNCT
cusj-12940	189	39	a	a	DET
cusj-12940	189	40	hybrid	hybrid	ADJ
cusj-12940	189	41	approach	approach	NOUN
cusj-12940	189	42	for	for	ADP
cusj-12940	189	43	3d	3d	NUM
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cusj-12940	189	46	calculation	calculation	NOUN
cusj-12940	189	47	.	.	PUNCT
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cusj-12940	190	13	s6	s6	PROPN
cusj-12940	190	14	protein	protein	NOUN
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cusj-12940	190	16	2	2	NUM
cusj-12940	190	17	inhibitors	inhibitor	NOUN
cusj-12940	190	18	to	to	PART
cusj-12940	190	19	suppress	suppress	VERB
cusj-12940	190	20	cell	cell	NOUN
cusj-12940	190	21	migration	migration	NOUN
cusj-12940	190	22	.	.	PUNCT
cusj-12940	191	1	j.	j.	PROPN
cusj-12940	191	2	med	med	PROPN
cusj-12940	191	3	.	.	PROPN
cusj-12940	191	4	chem	chem	PROPN
cusj-12940	191	5	.	.	PUNCT
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cusj-12940	192	2	,	,	PUNCT
cusj-12940	192	3	54	54	NUM
cusj-12940	192	4	,	,	PUNCT
cusj-12940	192	5	3564	3564	NUM
cusj-12940	192	6	-	-	SYM
cusj-12940	192	7	3574	3574	NUM
cusj-12940	192	8	.	.	PUNCT
cusj-12940	193	1	https://pubs.acs	https://pubs.ac	NOUN
cusj-12940	193	2	.	.	PUNCT
cusj-12940	194	1	org	org	ADJ
cusj-12940	194	2	/	/	SYM
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cusj-12940	194	4	/	/	SYM
cusj-12940	194	5	jm200139j	jm200139j	PROPN
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cusj-12940	195	2	10	10	NUM
cusj-12940	195	3	]	]	PUNCT
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cusj-12940	195	6	,	,	PUNCT
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cusj-12940	195	8	mc	mc	PROPN
cusj-12940	195	9	,	,	PUNCT
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cusj-12940	195	12	,	,	PUNCT
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cusj-12940	195	17	,	,	PUNCT
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cusj-12940	195	26	of	of	ADP
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cusj-12940	195	31	-	-	PUNCT
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cusj-12940	196	3	.	.	PUNCT
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cusj-12940	197	4	.	.	PUNCT
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cusj-12940	198	2	:	:	PUNCT
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cusj-12940	198	4	/	/	SYM
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cusj-12940	198	8	.	.	PUNCT
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cusj-12940	199	5	.	.	PUNCT
cusj-12940	200	1	pmid	pmid	NOUN
cusj-12940	200	2	:	:	PUNCT
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cusj-12940	200	6	:	:	PUNCT
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cusj-12940	200	8	.	.	PUNCT
cusj-12940	201	1	https://pubmed.ncbi.nlm.nih.gov/34006134/	https://pubmed.ncbi.nlm.nih.gov/34006134/	PROPN
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cusj-12940	202	5	.	.	PUNCT
cusj-12940	203	1	(	(	PUNCT
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cusj-12940	203	3	)	)	PUNCT
cusj-12940	203	4	.	.	PUNCT
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cusj-12940	204	4	.	.	PUNCT
cusj-12940	205	1	panreac	panreac	PROPN
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cusj-12940	206	6	]	]	X
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cusj-12940	206	9	,	,	PUNCT
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cusj-12940	207	2	mj	mj	PROPN
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cusj-12940	207	15	-	-	PUNCT
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cusj-12940	207	20	)	)	PUNCT
cusj-12940	207	21	,	,	PUNCT
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cusj-12940	207	25	inhibitor	inhibitor	NOUN
cusj-12940	207	26	.	.	PUNCT
cusj-12940	208	1	j	j	PROPN
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cusj-12940	208	4	.	.	PUNCT
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cusj-12940	209	3	-	-	PROPN
cusj-12940	209	4	36	36	NUM
cusj-12940	209	5	.	.	PUNCT
cusj-12940	210	1	doi	doi	NOUN
cusj-12940	210	2	:	:	PUNCT
cusj-12940	210	3	10.1002/	10.1002/	NUM
cusj-12940	210	4	jlb.60.3.328	jlb.60.3.328	NOUN
cusj-12940	210	5	.	.	PUNCT
cusj-12940	211	1	pmid	pmid	NOUN
cusj-12940	211	2	:	:	PUNCT
cusj-12940	211	3	8830789	8830789	NUM
cusj-12940	211	4	.	.	PUNCT
cusj-12940	212	1	https://pubmed	https://pubmed	X
cusj-12940	212	2	.	.	PUNCT
cusj-12940	212	3	ncbi.nlm.nih.gov/8830789/	ncbi.nlm.nih.gov/8830789/	X
cusj-12940	213	1	[	[	X
cusj-12940	213	2	13	13	NUM
cusj-12940	213	3	]	]	PUNCT
cusj-12940	213	4	sreelatha	sreelatha	PROPN
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cusj-12940	213	6	,	,	PUNCT
cusj-12940	213	7	malakar	malakar	PROPN
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cusj-12940	213	9	,	,	PUNCT
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cusj-12940	213	13	morchang	morchang	PROPN
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cusj-12940	213	16	srisawat	srisawat	ADJ
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cusj-12940	213	22	yenchitosomanus	yenchitosomanus	PROPN
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cusj-12940	213	24	,	,	PUNCT
cusj-12940	213	25	limjindaporn	limjindaporn	ADJ
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cusj-12940	213	28	protease	protease	NOUN
cusj-12940	213	29	inhibitor	inhibitor	NOUN
cusj-12940	213	30	aebsf	aebsf	ADV
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cusj-12940	213	32	dengue	dengue	NOUN
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cusj-12940	213	34	infection	infection	NOUN
cusj-12940	213	35	via	via	ADP
cusj-12940	213	36	decreased	decrease	VERB
cusj-12940	213	37	cholesterol	cholesterol	NOUN
cusj-12940	213	38	synthesis	synthesis	NOUN
cusj-12940	213	39	.	.	PUNCT
cusj-12940	214	1	virus	virus	NOUN
cusj-12940	214	2	res	re	NOUN
cusj-12940	214	3	.	.	PROPN
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cusj-12940	214	5	oct	oct	PROPN
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cusj-12940	214	7	.	.	PUNCT
cusj-12940	215	1	doi	doi	NOUN
cusj-12940	215	2	:	:	PUNCT
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cusj-12940	215	4	/	/	SYM
cusj-12940	215	5	j.	j.	PROPN
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