id	sid	tid	token	lemma	pos
cusj-5580	1	1	microsoft	microsoft	PROPN
cusj-5580	1	2	word	word	NOUN
cusj-5580	1	3	cusj	cusj	PROPN
cusj-5580	1	4	21.docx	21.docx	NUM
cusj-5580	1	5	_	_	PUNCT
cusj-5580	2	1	_	_	PUNCT
cusj-5580	3	1	_	_	PUNCT
cusj-5580	4	1	_	_	PUNCT
cusj-5580	5	1	_	_	PUNCT
cusj-5580	6	1	_	_	PUNCT
cusj-5580	7	1	_	_	PUNCT
cusj-5580	8	1	_	_	PUNCT
cusj-5580	9	1	_	_	PUNCT
cusj-5580	10	1	_	_	PUNCT
cusj-5580	11	1	_	_	PUNCT
cusj-5580	12	1	_	_	PUNCT
cusj-5580	13	1	_	_	PUNCT
cusj-5580	14	1	_	_	PUNCT
cusj-5580	15	1	_	_	PUNCT
cusj-5580	16	1	_	_	PUNCT
cusj-5580	17	1	_	_	PUNCT
cusj-5580	18	1	_	_	PUNCT
cusj-5580	19	1	_	_	PUNCT
cusj-5580	20	1	_	_	PUNCT
cusj-5580	21	1	_	_	PUNCT
cusj-5580	22	1	_	_	PUNCT
cusj-5580	23	1	_	_	PUNCT
cusj-5580	24	1	_	_	PUNCT
cusj-5580	25	1	_	_	PUNCT
cusj-5580	26	1	_	_	PUNCT
cusj-5580	27	1	_	_	PUNCT
cusj-5580	28	1	_	_	PUNCT
cusj-5580	29	1	_	_	PUNCT
cusj-5580	30	1	_	_	PUNCT
cusj-5580	31	1	_	_	PUNCT
cusj-5580	32	1	_	_	PUNCT
cusj-5580	33	1	_	_	PUNCT
cusj-5580	34	1	_	_	PUNCT
cusj-5580	35	1	_	_	PUNCT
cusj-5580	36	1	_	_	PUNCT
cusj-5580	37	1	_	_	PUNCT
cusj-5580	38	1	_	_	PUNCT
cusj-5580	39	1	_	_	PUNCT
cusj-5580	40	1	_	_	PUNCT
cusj-5580	41	1	_	_	PUNCT
cusj-5580	42	1	_	_	PUNCT
cusj-5580	43	1	_	_	PUNCT
cusj-5580	44	1	_	_	PUNCT
cusj-5580	45	1	_	_	PUNCT
cusj-5580	46	1	_	_	PUNCT
cusj-5580	47	1	_	_	PUNCT
cusj-5580	48	1	_	_	PUNCT
cusj-5580	49	1	_	_	PUNCT
cusj-5580	50	1	_	_	PUNCT
cusj-5580	51	1	_	_	PUNCT
cusj-5580	52	1	_	_	PUNCT
cusj-5580	53	1	_	_	PUNCT
cusj-5580	54	1	_	_	PUNCT
cusj-5580	55	1	_	_	PUNCT
cusj-5580	56	1	_	_	PUNCT
cusj-5580	57	1	_	_	PUNCT
cusj-5580	58	1	_	_	PUNCT
cusj-5580	59	1	_	_	PUNCT
cusj-5580	60	1	_	_	PUNCT
cusj-5580	61	1	_	_	PUNCT
cusj-5580	62	1	_	_	PUNCT
cusj-5580	63	1	_	_	PUNCT
cusj-5580	64	1	_	_	PUNCT
cusj-5580	65	1	_	_	PUNCT
cusj-5580	66	1	_	_	PUNCT
cusj-5580	67	1	_	_	PUNCT
cusj-5580	68	1	_	_	PUNCT
cusj-5580	69	1	_	_	PUNCT
cusj-5580	70	1	_	_	PUNCT
cusj-5580	71	1	_	_	PUNCT
cusj-5580	72	1	_	_	PUNCT
cusj-5580	73	1	_	_	PUNCT
cusj-5580	74	1	_	_	PUNCT
cusj-5580	75	1	_	_	PUNCT
cusj-5580	76	1	_	_	PUNCT
cusj-5580	77	1	_	_	PUNCT
cusj-5580	78	1	_	_	PUNCT
cusj-5580	79	1	_	_	PUNCT
cusj-5580	80	1	_	_	PUNCT
cusj-5580	80	2	cusj	cusj	VERB
cusj-5580	80	3	2019	2019	NUM
cusj-5580	80	4	_	_	PUNCT
cusj-5580	81	1	_	_	PUNCT
cusj-5580	82	1	_	_	PUNCT
cusj-5580	83	1	_	_	PUNCT
cusj-5580	84	1	_	_	PUNCT
cusj-5580	85	1	_	_	PUNCT
cusj-5580	86	1	_	_	PUNCT
cusj-5580	87	1	_	_	PUNCT
cusj-5580	88	1	_	_	PUNCT
cusj-5580	89	1	_	_	PUNCT
cusj-5580	90	1	_	_	PUNCT
cusj-5580	91	1	_	_	PUNCT
cusj-5580	92	1	_	_	PUNCT
cusj-5580	93	1	_	_	PUNCT
cusj-5580	94	1	_	_	PUNCT
cusj-5580	95	1	_	_	PUNCT
cusj-5580	96	1	_	_	PUNCT
cusj-5580	97	1	_	_	PUNCT
cusj-5580	98	1	_	_	PUNCT
cusj-5580	99	1	_	_	PUNCT
cusj-5580	100	1	_	_	PUNCT
cusj-5580	101	1	_	_	PUNCT
cusj-5580	102	1	_	_	PUNCT
cusj-5580	103	1	_	_	PUNCT
cusj-5580	104	1	_	_	PUNCT
cusj-5580	105	1	_	_	PUNCT
cusj-5580	106	1	_	_	PUNCT
cusj-5580	107	1	_	_	PUNCT
cusj-5580	108	1	_	_	PUNCT
cusj-5580	109	1	_	_	PUNCT
cusj-5580	110	1	_	_	PUNCT
cusj-5580	111	1	_	_	PUNCT
cusj-5580	112	1	_	_	PUNCT
cusj-5580	113	1	_	_	PUNCT
cusj-5580	114	1	_	_	PUNCT
cusj-5580	115	1	_	_	PUNCT
cusj-5580	116	1	_	_	PUNCT
cusj-5580	117	1	_	_	PUNCT
cusj-5580	118	1	_	_	PUNCT
cusj-5580	119	1	_	_	PUNCT
cusj-5580	120	1	_	_	PUNCT
cusj-5580	121	1	_	_	PUNCT
cusj-5580	122	1	_	_	PUNCT
cusj-5580	123	1	_	_	PUNCT
cusj-5580	124	1	_	_	PUNCT
cusj-5580	125	1	_	_	PUNCT
cusj-5580	126	1	_	_	PUNCT
cusj-5580	127	1	_	_	PUNCT
cusj-5580	128	1	_	_	PUNCT
cusj-5580	129	1	_	_	PUNCT
cusj-5580	130	1	_	_	PUNCT
cusj-5580	131	1	_	_	PUNCT
cusj-5580	132	1	_	_	PUNCT
cusj-5580	133	1	_	_	PUNCT
cusj-5580	134	1	_	_	PUNCT
cusj-5580	135	1	_	_	PUNCT
cusj-5580	136	1	_	_	PUNCT
cusj-5580	137	1	_	_	PUNCT
cusj-5580	138	1	_	_	PUNCT
cusj-5580	139	1	_	_	PUNCT
cusj-5580	140	1	_	_	PUNCT
cusj-5580	141	1	_	_	PUNCT
cusj-5580	142	1	_	_	PUNCT
cusj-5580	143	1	_	_	PUNCT
cusj-5580	144	1	_	_	PUNCT
cusj-5580	145	1	_	_	PUNCT
cusj-5580	146	1	_	_	PUNCT
cusj-5580	147	1	_	_	PUNCT
cusj-5580	148	1	_	_	PUNCT
cusj-5580	149	1	_	_	PUNCT
cusj-5580	150	1	_	_	PUNCT
cusj-5580	151	1	_	_	PUNCT
cusj-5580	152	1	_	_	PUNCT
cusj-5580	153	1	_	_	PUNCT
cusj-5580	154	1	_	_	PUNCT
cusj-5580	155	1	_	_	PUNCT
cusj-5580	156	1	_	_	PUNCT
cusj-5580	157	1	_	_	PUNCT
cusj-5580	158	1	_	_	PUNCT
cusj-5580	159	1	_	_	PUNCT
cusj-5580	160	1	_	_	PUNCT
cusj-5580	161	1	_	_	PUNCT
cusj-5580	162	1	_	_	PUNCT
cusj-5580	163	1	_	_	PUNCT
cusj-5580	164	1	_	_	PUNCT
cusj-5580	165	1	_	_	PUNCT
cusj-5580	166	1	_	_	PUNCT
cusj-5580	167	1	_	_	PUNCT
cusj-5580	168	1	_	_	PUNCT
cusj-5580	169	1	_	_	PUNCT
cusj-5580	170	1	21	21	NUM
cusj-5580	170	2	abstract	abstract	ADJ
cusj-5580	170	3	—	—	PUNCT
cusj-5580	170	4	nilotinib	nilotinib	NOUN
cusj-5580	170	5	(	(	PUNCT
cusj-5580	170	6	tasigna	tasigna	PROPN
cusj-5580	170	7	)	)	PUNCT
cusj-5580	170	8	is	be	AUX
cusj-5580	170	9	a	a	DET
cusj-5580	170	10	drug	drug	NOUN
cusj-5580	170	11	used	use	VERB
cusj-5580	170	12	to	to	PART
cusj-5580	170	13	treat	treat	VERB
cusj-5580	170	14	chronic	chronic	ADJ
cusj-5580	170	15	myelogenous	myelogenous	ADJ
cusj-5580	170	16	leukemia	leukemia	NOUN
cusj-5580	170	17	(	(	PUNCT
cusj-5580	170	18	cml	cml	PROPN
cusj-5580	170	19	)	)	PUNCT
cusj-5580	170	20	,	,	PUNCT
cusj-5580	170	21	a	a	DET
cusj-5580	170	22	disease	disease	NOUN
cusj-5580	170	23	which	which	PRON
cusj-5580	170	24	currently	currently	ADV
cusj-5580	170	25	affects	affect	VERB
cusj-5580	170	26	over	over	ADP
cusj-5580	170	27	100,000	100,000	NUM
cusj-5580	170	28	people	people	NOUN
cusj-5580	170	29	in	in	ADP
cusj-5580	170	30	the	the	DET
cusj-5580	170	31	u.s	u.s	PROPN
cusj-5580	170	32	.	.	PROPN
cusj-5580	170	33	the	the	DET
cusj-5580	170	34	drug	drug	NOUN
cusj-5580	170	35	is	be	AUX
cusj-5580	170	36	manufactured	manufacture	VERB
cusj-5580	170	37	by	by	ADP
cusj-5580	170	38	novartis	novartis	PROPN
cusj-5580	170	39	and	and	CCONJ
cusj-5580	170	40	has	have	AUX
cusj-5580	170	41	been	be	AUX
cusj-5580	170	42	one	one	NUM
cusj-5580	170	43	of	of	ADP
cusj-5580	170	44	its	its	PRON
cusj-5580	170	45	most	most	ADV
cusj-5580	170	46	profitable	profitable	ADJ
cusj-5580	170	47	,	,	PUNCT
cusj-5580	170	48	bringing	bring	VERB
cusj-5580	170	49	in	in	ADP
cusj-5580	170	50	a	a	DET
cusj-5580	170	51	total	total	ADJ
cusj-5580	170	52	revenue	revenue	NOUN
cusj-5580	170	53	of	of	ADP
cusj-5580	170	54	well	well	ADV
cusj-5580	170	55	over	over	ADP
cusj-5580	170	56	$	$	SYM
cusj-5580	170	57	2	2	NUM
cusj-5580	170	58	billion	billion	NUM
cusj-5580	170	59	usd	usd	NOUN
cusj-5580	170	60	in	in	ADP
cusj-5580	170	61	2016	2016	NUM
cusj-5580	170	62	.	.	PUNCT
cusj-5580	171	1	novartis	novartis	PROPN
cusj-5580	171	2	’s	’s	PART
cusj-5580	171	3	patent	patent	NOUN
cusj-5580	171	4	on	on	ADP
cusj-5580	171	5	tasigna	tasigna	PROPN
cusj-5580	171	6	is	be	AUX
cusj-5580	171	7	set	set	VERB
cusj-5580	171	8	to	to	PART
cusj-5580	171	9	expire	expire	VERB
cusj-5580	171	10	in	in	ADP
cusj-5580	171	11	2023	2023	NUM
cusj-5580	171	12	and	and	CCONJ
cusj-5580	171	13	cheaper	cheap	ADJ
cusj-5580	171	14	,	,	PUNCT
cusj-5580	171	15	generic	generic	ADJ
cusj-5580	171	16	versions	version	NOUN
cusj-5580	171	17	of	of	ADP
cusj-5580	171	18	the	the	DET
cusj-5580	171	19	drug	drug	NOUN
cusj-5580	171	20	will	will	AUX
cusj-5580	171	21	soon	soon	ADV
cusj-5580	171	22	be	be	AUX
cusj-5580	171	23	in	in	ADP
cusj-5580	171	24	great	great	ADJ
cusj-5580	171	25	demand	demand	NOUN
cusj-5580	171	26	.	.	PUNCT
cusj-5580	172	1	an	an	DET
cusj-5580	172	2	assessment	assessment	NOUN
cusj-5580	172	3	of	of	ADP
cusj-5580	172	4	novartis	novartis	PROPN
cusj-5580	172	5	’s	’s	PART
cusj-5580	172	6	existing	exist	VERB
cusj-5580	172	7	patent	patent	NOUN
cusj-5580	172	8	on	on	ADP
cusj-5580	172	9	the	the	DET
cusj-5580	172	10	synthesis	synthesis	NOUN
cusj-5580	172	11	of	of	ADP
cusj-5580	172	12	tasigna	tasigna	PROPN
cusj-5580	172	13	indicates	indicate	VERB
cusj-5580	172	14	many	many	ADJ
cusj-5580	172	15	drawbacks	drawback	NOUN
cusj-5580	172	16	in	in	ADP
cusj-5580	172	17	the	the	DET
cusj-5580	172	18	current	current	ADJ
cusj-5580	172	19	process	process	NOUN
cusj-5580	172	20	.	.	PUNCT
cusj-5580	173	1	namely	namely	ADV
cusj-5580	173	2	,	,	PUNCT
cusj-5580	173	3	the	the	DET
cusj-5580	173	4	novartis	novartis	NOUN
cusj-5580	173	5	synthesis	synthesis	NOUN
cusj-5580	173	6	requires	require	VERB
cusj-5580	173	7	multiple	multiple	ADJ
cusj-5580	173	8	days	day	NOUN
cusj-5580	173	9	of	of	ADP
cusj-5580	173	10	reaction	reaction	NOUN
cusj-5580	173	11	,	,	PUNCT
cusj-5580	173	12	nearly	nearly	ADV
cusj-5580	173	13	a	a	DET
cusj-5580	173	14	dozen	dozen	NOUN
cusj-5580	173	15	steps	step	NOUN
cusj-5580	173	16	,	,	PUNCT
cusj-5580	173	17	multiple	multiple	ADJ
cusj-5580	173	18	solvent	solvent	NOUN
cusj-5580	173	19	switching	switching	NOUN
cusj-5580	173	20	processes	process	NOUN
cusj-5580	173	21	,	,	PUNCT
cusj-5580	173	22	and	and	CCONJ
cusj-5580	173	23	gives	give	VERB
cusj-5580	173	24	very	very	ADV
cusj-5580	173	25	low	low	ADJ
cusj-5580	173	26	yields	yield	NOUN
cusj-5580	173	27	.	.	PUNCT
cusj-5580	174	1	on	on	ADP
cusj-5580	174	2	the	the	DET
cusj-5580	174	3	other	other	ADJ
cusj-5580	174	4	hand	hand	NOUN
cusj-5580	174	5	,	,	PUNCT
cusj-5580	174	6	work	work	NOUN
cusj-5580	174	7	published	publish	VERB
cusj-5580	174	8	by	by	ADP
cusj-5580	174	9	buchwald	buchwald	NOUN
cusj-5580	174	10	and	and	CCONJ
cusj-5580	174	11	coworkers	coworker	NOUN
cusj-5580	174	12	has	have	AUX
cusj-5580	174	13	shown	show	VERB
cusj-5580	174	14	an	an	DET
cusj-5580	174	15	efficient	efficient	ADJ
cusj-5580	174	16	method	method	NOUN
cusj-5580	174	17	of	of	ADP
cusj-5580	174	18	synthesizing	synthesize	VERB
cusj-5580	174	19	nilotinib	nilotinib	NOUN
cusj-5580	174	20	in	in	ADP
cusj-5580	174	21	fewer	few	ADJ
cusj-5580	174	22	than	than	ADP
cusj-5580	174	23	four	four	NUM
cusj-5580	174	24	steps	step	NOUN
cusj-5580	174	25	,	,	PUNCT
cusj-5580	174	26	in	in	ADP
cusj-5580	174	27	less	less	ADJ
cusj-5580	174	28	than	than	ADP
cusj-5580	174	29	24	24	NUM
cusj-5580	174	30	hours	hour	NOUN
cusj-5580	174	31	,	,	PUNCT
cusj-5580	174	32	and	and	CCONJ
cusj-5580	174	33	at	at	ADP
cusj-5580	174	34	>	>	SYM
cusj-5580	174	35	85	85	NUM
cusj-5580	174	36	%	%	NOUN
cusj-5580	174	37	yields	yield	NOUN
cusj-5580	174	38	.	.	PUNCT
cusj-5580	175	1	unfortunately	unfortunately	ADV
cusj-5580	175	2	,	,	PUNCT
cusj-5580	175	3	the	the	DET
cusj-5580	175	4	buchwald	buchwald	NOUN
cusj-5580	175	5	reaction	reaction	NOUN
cusj-5580	175	6	has	have	AUX
cusj-5580	175	7	only	only	ADV
cusj-5580	175	8	ever	ever	ADV
cusj-5580	175	9	been	be	AUX
cusj-5580	175	10	applied	apply	VERB
cusj-5580	175	11	in	in	ADP
cusj-5580	175	12	a	a	DET
cusj-5580	175	13	laboratory	laboratory	NOUN
cusj-5580	175	14	setting	setting	NOUN
cusj-5580	175	15	and	and	CCONJ
cusj-5580	175	16	has	have	AUX
cusj-5580	175	17	never	never	ADV
cusj-5580	175	18	been	be	AUX
cusj-5580	175	19	scaled	scale	VERB
cusj-5580	175	20	to	to	ADP
cusj-5580	175	21	an	an	DET
cusj-5580	175	22	industrial	industrial	ADJ
cusj-5580	175	23	level	level	NOUN
cusj-5580	175	24	.	.	PUNCT
cusj-5580	176	1	thus	thus	ADV
cusj-5580	176	2	,	,	PUNCT
cusj-5580	176	3	it	it	PRON
cusj-5580	176	4	was	be	AUX
cusj-5580	176	5	the	the	DET
cusj-5580	176	6	goal	goal	NOUN
cusj-5580	176	7	of	of	ADP
cusj-5580	176	8	this	this	DET
cusj-5580	176	9	investigation	investigation	NOUN
cusj-5580	176	10	to	to	PART
cusj-5580	176	11	develop	develop	VERB
cusj-5580	176	12	an	an	DET
cusj-5580	176	13	industrially	industrially	ADV
cusj-5580	176	14	scaled	scale	VERB
cusj-5580	176	15	,	,	PUNCT
cusj-5580	176	16	flow	flow	NOUN
cusj-5580	176	17	-	-	PUNCT
cusj-5580	176	18	based	base	VERB
cusj-5580	176	19	synthesis	synthesis	NOUN
cusj-5580	176	20	of	of	ADP
cusj-5580	176	21	the	the	DET
cusj-5580	176	22	buchwald	buchwald	ADJ
cusj-5580	176	23	synthesis	synthesis	NOUN
cusj-5580	176	24	of	of	ADP
cusj-5580	176	25	nilotinib	nilotinib	NOUN
cusj-5580	176	26	.	.	PUNCT
cusj-5580	177	1	for	for	ADP
cusj-5580	177	2	this	this	DET
cusj-5580	177	3	investigation	investigation	NOUN
cusj-5580	177	4	,	,	PUNCT
cusj-5580	177	5	our	our	PRON
cusj-5580	177	6	team	team	NOUN
cusj-5580	177	7	assumed	assume	VERB
cusj-5580	177	8	the	the	DET
cusj-5580	177	9	role	role	NOUN
cusj-5580	177	10	of	of	ADP
cusj-5580	177	11	a	a	DET
cusj-5580	177	12	generic	generic	ADJ
cusj-5580	177	13	pharmaceutical	pharmaceutical	ADJ
cusj-5580	177	14	company	company	NOUN
cusj-5580	177	15	with	with	ADP
cusj-5580	177	16	a	a	DET
cusj-5580	177	17	hypothetical	hypothetical	ADJ
cusj-5580	177	18	goal	goal	NOUN
cusj-5580	177	19	of	of	ADP
cusj-5580	177	20	producing	produce	VERB
cusj-5580	177	21	15	15	NUM
cusj-5580	177	22	%	%	NOUN
cusj-5580	177	23	of	of	ADP
cusj-5580	177	24	the	the	DET
cusj-5580	177	25	u.s	u.s	PROPN
cusj-5580	177	26	.	.	PROPN
cusj-5580	177	27	market	market	NOUN
cusj-5580	177	28	share	share	NOUN
cusj-5580	177	29	of	of	ADP
cusj-5580	177	30	nilotinib	nilotinib	NOUN
cusj-5580	177	31	(	(	PUNCT
cusj-5580	177	32	1150	1150	NUM
cusj-5580	177	33	kg	kg	NOUN
cusj-5580	177	34	of	of	ADP
cusj-5580	177	35	nilotinib	nilotinib	NOUN
cusj-5580	177	36	/	/	SYM
cusj-5580	177	37	year	year	NOUN
cusj-5580	177	38	)	)	PUNCT
cusj-5580	177	39	.	.	PUNCT
cusj-5580	178	1	utilizing	utilize	VERB
cusj-5580	178	2	chemical	chemical	NOUN
cusj-5580	178	3	reaction	reaction	NOUN
cusj-5580	178	4	modeling	model	VERB
cusj-5580	178	5	software	software	NOUN
cusj-5580	178	6	,	,	PUNCT
cusj-5580	178	7	chemcad	chemcad	PROPN
cusj-5580	178	8	,	,	PUNCT
cusj-5580	178	9	a	a	DET
cusj-5580	178	10	chemical	chemical	NOUN
cusj-5580	178	11	process	process	NOUN
cusj-5580	178	12	for	for	ADP
cusj-5580	178	13	the	the	DET
cusj-5580	178	14	large	large	ADJ
cusj-5580	178	15	scale	scale	NOUN
cusj-5580	178	16	buchwald	buchwald	NOUN
cusj-5580	178	17	synthesis	synthesis	NOUN
cusj-5580	178	18	of	of	ADP
cusj-5580	178	19	nilotinib	nilotinib	NOUN
cusj-5580	178	20	was	be	AUX
cusj-5580	178	21	successfully	successfully	ADV
cusj-5580	178	22	designed	design	VERB
cusj-5580	178	23	at	at	ADP
cusj-5580	178	24	the	the	DET
cusj-5580	178	25	1150	1150	NUM
cusj-5580	178	26	kg	kg	NOUN
cusj-5580	178	27	production	production	NOUN
cusj-5580	178	28	capacity	capacity	NOUN
cusj-5580	178	29	of	of	ADP
cusj-5580	178	30	the	the	DET
cusj-5580	178	31	active	active	ADJ
cusj-5580	178	32	pharmaceutical	pharmaceutical	ADJ
cusj-5580	178	33	ingredient	ingredient	NOUN
cusj-5580	178	34	of	of	ADP
cusj-5580	178	35	nilotinib	nilotinib	NOUN
cusj-5580	178	36	per	per	ADP
cusj-5580	178	37	year	year	NOUN
cusj-5580	178	38	.	.	PUNCT
cusj-5580	179	1	economic	economic	ADJ
cusj-5580	179	2	analysis	analysis	NOUN
cusj-5580	179	3	demonstrated	demonstrate	VERB
cusj-5580	179	4	the	the	DET
cusj-5580	179	5	fiscal	fiscal	ADJ
cusj-5580	179	6	viability	viability	NOUN
cusj-5580	179	7	of	of	ADP
cusj-5580	179	8	this	this	DET
cusj-5580	179	9	process	process	NOUN
cusj-5580	179	10	with	with	ADP
cusj-5580	179	11	estimated	estimate	VERB
cusj-5580	179	12	gross	gross	ADJ
cusj-5580	179	13	revenue	revenue	NOUN
cusj-5580	179	14	of	of	ADP
cusj-5580	179	15	>	>	PUNCT
cusj-5580	179	16	$	$	SYM
cusj-5580	179	17	250	250	NUM
cusj-5580	179	18	million	million	NUM
cusj-5580	179	19	usd	usd	NOUN
cusj-5580	179	20	/	/	SYM
cusj-5580	179	21	year	year	NOUN
cusj-5580	179	22	even	even	ADV
cusj-5580	179	23	with	with	ADP
cusj-5580	179	24	a	a	DET
cusj-5580	179	25	predicted	predict	VERB
cusj-5580	179	26	60	60	NUM
cusj-5580	179	27	%	%	NOUN
cusj-5580	179	28	drop	drop	NOUN
cusj-5580	179	29	in	in	ADP
cusj-5580	179	30	generic	generic	ADJ
cusj-5580	179	31	drug	drug	NOUN
cusj-5580	179	32	price	price	NOUN
cusj-5580	179	33	factored	factor	VERB
cusj-5580	179	34	in	in	ADP
cusj-5580	179	35	.	.	PUNCT
cusj-5580	180	1	this	this	PRON
cusj-5580	180	2	,	,	PUNCT
cusj-5580	180	3	we	we	PRON
cusj-5580	180	4	envision	envision	VERB
cusj-5580	180	5	,	,	PUNCT
cusj-5580	180	6	would	would	AUX
cusj-5580	180	7	serve	serve	VERB
cusj-5580	180	8	as	as	ADP
cusj-5580	180	9	an	an	DET
cusj-5580	180	10	important	important	ADJ
cusj-5580	180	11	improvement	improvement	NOUN
cusj-5580	180	12	in	in	ADP
cusj-5580	180	13	the	the	DET
cusj-5580	180	14	efficiency	efficiency	NOUN
cusj-5580	180	15	of	of	ADP
cusj-5580	180	16	industrial	industrial	ADJ
cusj-5580	180	17	level	level	NOUN
cusj-5580	180	18	synthesis	synthesis	NOUN
cusj-5580	180	19	of	of	ADP
cusj-5580	180	20	a	a	DET
cusj-5580	180	21	life	life	NOUN
cusj-5580	180	22	-	-	PUNCT
cusj-5580	180	23	saving	save	VERB
cusj-5580	180	24	cancer	cancer	NOUN
cusj-5580	180	25	drug	drug	NOUN
cusj-5580	180	26	.	.	PUNCT
cusj-5580	181	1	i.	i.	PROPN
cusj-5580	181	2	introduction	introduction	NOUN
cusj-5580	181	3	the	the	DET
cusj-5580	181	4	use	use	NOUN
cusj-5580	181	5	of	of	ADP
cusj-5580	181	6	tyrosine	tyrosine	NOUN
cusj-5580	181	7	kinase	kinase	PROPN
cusj-5580	181	8	inhibitors	inhibitor	NOUN
cusj-5580	181	9	(	(	PUNCT
cusj-5580	181	10	tkis	tkis	NOUN
cusj-5580	181	11	)	)	PUNCT
cusj-5580	181	12	to	to	PART
cusj-5580	181	13	treat	treat	VERB
cusj-5580	181	14	chronic	chronic	ADJ
cusj-5580	181	15	myeloid	myeloid	NOUN
cusj-5580	181	16	leukemia	leukemia	NOUN
cusj-5580	181	17	(	(	PUNCT
cusj-5580	181	18	cml	cml	PROPN
cusj-5580	181	19	)	)	PUNCT
cusj-5580	181	20	has	have	AUX
cusj-5580	181	21	been	be	AUX
cusj-5580	181	22	one	one	NUM
cusj-5580	181	23	of	of	ADP
cusj-5580	181	24	the	the	DET
cusj-5580	181	25	greatest	great	ADJ
cusj-5580	181	26	breakthroughs	breakthrough	NOUN
cusj-5580	181	27	in	in	ADP
cusj-5580	181	28	modern	modern	ADJ
cusj-5580	181	29	oncology	oncology	NOUN
cusj-5580	181	30	.	.	PUNCT
cusj-5580	182	1	the	the	DET
cusj-5580	182	2	advent	advent	NOUN
cusj-5580	182	3	and	and	CCONJ
cusj-5580	182	4	introduction	introduction	NOUN
cusj-5580	182	5	of	of	ADP
cusj-5580	182	6	tkis	tkis	NOUN
cusj-5580	182	7	into	into	ADP
cusj-5580	182	8	the	the	DET
cusj-5580	182	9	clinic	clinic	NOUN
cusj-5580	182	10	has	have	AUX
cusj-5580	182	11	extended	extend	VERB
cusj-5580	182	12	8year	8year	NUM
cusj-5580	182	13	survival	survival	NOUN
cusj-5580	182	14	rates	rate	NOUN
cusj-5580	182	15	of	of	ADP
cusj-5580	182	16	patients	patient	NOUN
cusj-5580	182	17	with	with	ADP
cusj-5580	182	18	cml	cml	PROPN
cusj-5580	182	19	from	from	ADP
cusj-5580	182	20	<	<	X
cusj-5580	182	21	15	15	NUM
cusj-5580	182	22	%	%	NOUN
cusj-5580	182	23	in	in	ADP
cusj-5580	182	24	the	the	DET
cusj-5580	182	25	1980s	1980	NOUN
cusj-5580	182	26	to	to	ADP
cusj-5580	182	27	nearly	nearly	ADV
cusj-5580	182	28	90	90	NUM
cusj-5580	182	29	%	%	NOUN
cusj-5580	182	30	in	in	ADP
cusj-5580	182	31	2012	2012	NUM
cusj-5580	182	32	(	(	PUNCT
cusj-5580	182	33	kantarjian	kantarjian	X
cusj-5580	182	34	et	et	PROPN
cusj-5580	182	35	al	al	PROPN
cusj-5580	182	36	.	.	PROPN
cusj-5580	182	37	,	,	PUNCT
cusj-5580	182	38	2012	2012	NUM
cusj-5580	182	39	)	)	PUNCT
cusj-5580	182	40	.	.	PUNCT
cusj-5580	183	1	even	even	ADV
cusj-5580	183	2	today	today	NOUN
cusj-5580	183	3	,	,	PUNCT
cusj-5580	183	4	over	over	ADP
cusj-5580	183	5	10,000	10,000	NUM
cusj-5580	183	6	people	people	NOUN
cusj-5580	183	7	each	each	DET
cusj-5580	183	8	year	year	NOUN
cusj-5580	183	9	are	be	AUX
cusj-5580	183	10	newly	newly	ADV
cusj-5580	183	11	diagnosed	diagnose	VERB
cusj-5580	183	12	with	with	ADP
cusj-5580	183	13	cml	cml	PROPN
cusj-5580	183	14	and	and	CCONJ
cusj-5580	183	15	the	the	DET
cusj-5580	183	16	vast	vast	ADJ
cusj-5580	183	17	majority	majority	NOUN
cusj-5580	183	18	,	,	PUNCT
cusj-5580	183	19	if	if	SCONJ
cusj-5580	183	20	not	not	PART
cusj-5580	183	21	all	all	PRON
cusj-5580	183	22	,	,	PUNCT
cusj-5580	183	23	of	of	ADP
cusj-5580	183	24	these	these	DET
cusj-5580	183	25	patients	patient	NOUN
cusj-5580	183	26	will	will	AUX
cusj-5580	183	27	rely	rely	VERB
cusj-5580	183	28	on	on	ADP
cusj-5580	183	29	tkis	tkis	PROPN
cusj-5580	183	30	(	(	PUNCT
cusj-5580	183	31	national	national	PROPN
cusj-5580	183	32	cancer	cancer	PROPN
cusj-5580	183	33	institute	institute	PROPN
cusj-5580	183	34	,	,	PUNCT
cusj-5580	183	35	2014	2014	NUM
cusj-5580	183	36	)	)	PUNCT
cusj-5580	183	37	.	.	PUNCT
cusj-5580	184	1	the	the	DET
cusj-5580	184	2	patent	patent	NOUN
cusj-5580	184	3	for	for	ADP
cusj-5580	184	4	novartis	novartis	PROPN
cusj-5580	184	5	’s	’s	PART
cusj-5580	184	6	original	original	ADJ
cusj-5580	184	7	first	first	ADJ
cusj-5580	184	8	-	-	PUNCT
cusj-5580	184	9	generation	generation	NOUN
cusj-5580	184	10	tki	tki	NOUN
cusj-5580	184	11	,	,	PUNCT
cusj-5580	184	12	known	know	VERB
cusj-5580	184	13	as	as	ADP
cusj-5580	184	14	gleevec	gleevec	PROPN
cusj-5580	184	15	(	(	PUNCT
cusj-5580	184	16	imatinib	imatinib	NOUN
cusj-5580	184	17	)	)	PUNCT
cusj-5580	184	18	,	,	PUNCT
cusj-5580	184	19	expired	expire	VERB
cusj-5580	184	20	in	in	ADP
cusj-5580	184	21	2016	2016	NUM
cusj-5580	184	22	.	.	PUNCT
cusj-5580	185	1	to	to	PART
cusj-5580	185	2	mitigate	mitigate	VERB
cusj-5580	185	3	its	its	PRON
cusj-5580	185	4	loss	loss	NOUN
cusj-5580	185	5	of	of	ADP
cusj-5580	185	6	profit	profit	NOUN
cusj-5580	185	7	and	and	CCONJ
cusj-5580	185	8	market	market	NOUN
cusj-5580	185	9	share	share	NOUN
cusj-5580	185	10	,	,	PUNCT
cusj-5580	185	11	novartis	novartis	PROPN
cusj-5580	185	12	developed	develop	VERB
cusj-5580	185	13	a	a	DET
cusj-5580	185	14	second	second	ADJ
cusj-5580	185	15	-	-	PUNCT
cusj-5580	185	16	generation	generation	NOUN
cusj-5580	185	17	tki	tki	NOUN
cusj-5580	185	18	known	know	VERB
cusj-5580	185	19	as	as	ADP
cusj-5580	185	20	tasigna	tasigna	PROPN
cusj-5580	185	21	(	(	PUNCT
cusj-5580	185	22	nilotinib	nilotinib	NOUN
cusj-5580	185	23	)	)	PUNCT
cusj-5580	185	24	,	,	PUNCT
cusj-5580	185	25	shown	show	VERB
cusj-5580	185	26	in	in	ADP
cusj-5580	185	27	fig	fig	NOUN
cusj-5580	185	28	.	.	PUNCT
cusj-5580	186	1	1	1	X
cusj-5580	186	2	.	.	PUNCT
cusj-5580	186	3	tasigna	tasigna	PROPN
cusj-5580	186	4	is	be	AUX
cusj-5580	186	5	designed	design	VERB
cusj-5580	186	6	to	to	PART
cusj-5580	186	7	be	be	AUX
cusj-5580	186	8	more	more	ADV
cusj-5580	186	9	potent	potent	ADJ
cusj-5580	186	10	in	in	ADP
cusj-5580	186	11	treating	treat	VERB
cusj-5580	186	12	cml	cml	PROPN
cusj-5580	186	13	than	than	ADP
cusj-5580	186	14	its	its	PRON
cusj-5580	186	15	first	first	ADJ
cusj-5580	186	16	-	-	PUNCT
cusj-5580	186	17	generation	generation	NOUN
cusj-5580	186	18	counterpart	counterpart	NOUN
cusj-5580	186	19	and	and	CCONJ
cusj-5580	186	20	also	also	ADV
cusj-5580	186	21	addresses	address	VERB
cusj-5580	186	22	many	many	ADJ
cusj-5580	186	23	of	of	ADP
cusj-5580	186	24	the	the	DET
cusj-5580	186	25	challenges	challenge	NOUN
cusj-5580	186	26	of	of	ADP
cusj-5580	186	27	chemotherapy	chemotherapy	NOUN
cusj-5580	186	28	resistance	resistance	NOUN
cusj-5580	186	29	that	that	PRON
cusj-5580	186	30	were	be	AUX
cusj-5580	186	31	faced	face	VERB
cusj-5580	186	32	by	by	ADP
cusj-5580	186	33	gleevec	gleevec	PROPN
cusj-5580	186	34	(	(	PUNCT
cusj-5580	186	35	huang	huang	PROPN
cusj-5580	186	36	et	et	PROPN
cusj-5580	186	37	al	al	PROPN
cusj-5580	186	38	.	.	PROPN
cusj-5580	186	39	,	,	PUNCT
cusj-5580	186	40	2007	2007	NUM
cusj-5580	186	41	)	)	PUNCT
cusj-5580	186	42	.	.	PUNCT
cusj-5580	187	1	tasigna	tasigna	PROPN
cusj-5580	187	2	received	receive	VERB
cusj-5580	187	3	its	its	PRON
cusj-5580	187	4	final	final	ADJ
cusj-5580	187	5	fda	fda	PROPN
cusj-5580	187	6	approval	approval	NOUN
cusj-5580	187	7	to	to	PART
cusj-5580	187	8	treat	treat	VERB
cusj-5580	187	9	cml	cml	PROPN
cusj-5580	187	10	in	in	ADP
cusj-5580	187	11	2010	2010	NUM
cusj-5580	187	12	.	.	PUNCT
cusj-5580	188	1	however	however	ADV
cusj-5580	188	2	,	,	PUNCT
cusj-5580	188	3	novartis	novartis	PROPN
cusj-5580	188	4	’s	’s	PART
cusj-5580	188	5	patent	patent	NOUN
cusj-5580	188	6	on	on	ADP
cusj-5580	188	7	tasigna	tasigna	PROPN
cusj-5580	188	8	is	be	AUX
cusj-5580	188	9	set	set	VERB
cusj-5580	188	10	to	to	PART
cusj-5580	188	11	expire	expire	VERB
cusj-5580	188	12	in	in	ADP
cusj-5580	188	13	2023	2023	NUM
cusj-5580	188	14	.	.	PUNCT
cusj-5580	189	1	this	this	PRON
cusj-5580	189	2	makes	make	VERB
cusj-5580	189	3	it	it	PRON
cusj-5580	189	4	a	a	DET
cusj-5580	189	5	particularly	particularly	ADV
cusj-5580	189	6	opportune	opportune	ADJ
cusj-5580	189	7	time	time	NOUN
cusj-5580	189	8	to	to	PART
cusj-5580	189	9	plan	plan	VERB
cusj-5580	189	10	the	the	DET
cusj-5580	189	11	development	development	NOUN
cusj-5580	189	12	of	of	ADP
cusj-5580	189	13	generic	generic	ADJ
cusj-5580	189	14	versions	version	NOUN
cusj-5580	189	15	of	of	ADP
cusj-5580	189	16	tasigna	tasigna	NOUN
cusj-5580	189	17	so	so	SCONJ
cusj-5580	189	18	that	that	SCONJ
cusj-5580	189	19	once	once	SCONJ
cusj-5580	189	20	novartis	novartis	PROPN
cusj-5580	189	21	’s	’s	PART
cusj-5580	189	22	patent	patent	NOUN
cusj-5580	189	23	on	on	ADP
cusj-5580	189	24	the	the	DET
cusj-5580	189	25	production	production	NOUN
cusj-5580	189	26	of	of	ADP
cusj-5580	189	27	tasigna	tasigna	PROPN
cusj-5580	189	28	expires	expire	NOUN
cusj-5580	189	29	,	,	PUNCT
cusj-5580	189	30	generic	generic	ADJ
cusj-5580	189	31	production	production	NOUN
cusj-5580	189	32	can	can	AUX
cusj-5580	189	33	begin	begin	VERB
cusj-5580	189	34	immediately	immediately	ADV
cusj-5580	189	35	.	.	PUNCT
cusj-5580	190	1	in	in	ADP
cusj-5580	190	2	2015	2015	NUM
cusj-5580	190	3	tasigna	tasigna	PROPN
cusj-5580	190	4	represented	represent	VERB
cusj-5580	190	5	12.8	12.8	NUM
cusj-5580	190	6	%	%	NOUN
cusj-5580	190	7	of	of	ADP
cusj-5580	190	8	the	the	DET
cusj-5580	190	9	current	current	ADJ
cusj-5580	190	10	market	market	NOUN
cusj-5580	190	11	share	share	NOUN
cusj-5580	190	12	of	of	ADP
cusj-5580	190	13	all	all	DET
cusj-5580	190	14	tki	tki	NOUN
cusj-5580	190	15	drugs	drug	NOUN
cusj-5580	190	16	for	for	ADP
cusj-5580	190	17	cml	cml	PROPN
cusj-5580	190	18	(	(	PUNCT
cusj-5580	190	19	bloudek	bloudek	PROPN
cusj-5580	190	20	et	et	PROPN
cusj-5580	190	21	al	al	PROPN
cusj-5580	190	22	.	.	PROPN
cusj-5580	190	23	,	,	PUNCT
cusj-5580	190	24	2015	2015	NUM
cusj-5580	190	25	)	)	PUNCT
cusj-5580	190	26	.	.	PUNCT
cusj-5580	191	1	additionally	additionally	ADV
cusj-5580	191	2	,	,	PUNCT
cusj-5580	191	3	it	it	PRON
cusj-5580	191	4	is	be	AUX
cusj-5580	191	5	currently	currently	ADV
cusj-5580	191	6	predicted	predict	VERB
cusj-5580	191	7	that	that	SCONJ
cusj-5580	191	8	the	the	DET
cusj-5580	191	9	incidence	incidence	NOUN
cusj-5580	191	10	of	of	ADP
cusj-5580	191	11	cml	cml	PROPN
cusj-5580	191	12	will	will	AUX
cusj-5580	191	13	increase	increase	VERB
cusj-5580	191	14	with	with	ADP
cusj-5580	191	15	an	an	DET
cusj-5580	191	16	estimated	estimate	VERB
cusj-5580	191	17	prevalence	prevalence	NOUN
cusj-5580	191	18	of	of	ADP
cusj-5580	191	19	112,000	112,000	NUM
cusj-5580	191	20	patients	patient	NOUN
cusj-5580	191	21	in	in	ADP
cusj-5580	191	22	the	the	DET
cusj-5580	191	23	us	we	PRON
cusj-5580	191	24	by	by	ADP
cusj-5580	191	25	2020	2020	NUM
cusj-5580	191	26	(	(	PUNCT
cusj-5580	191	27	cortes	corte	VERB
cusj-5580	191	28	et	et	PROPN
cusj-5580	191	29	al	al	PROPN
cusj-5580	191	30	.	.	PROPN
cusj-5580	191	31	,	,	PUNCT
cusj-5580	191	32	2012	2012	NUM
cusj-5580	191	33	)	)	PUNCT
cusj-5580	191	34	.	.	PUNCT
cusj-5580	192	1	by	by	ADP
cusj-5580	192	2	the	the	DET
cusj-5580	192	3	year	year	NOUN
cusj-5580	192	4	that	that	PRON
cusj-5580	192	5	novartis	novartis	NOUN
cusj-5580	192	6	’s	’s	PART
cusj-5580	192	7	patent	patent	NOUN
cusj-5580	192	8	on	on	ADP
cusj-5580	192	9	tasigna	tasigna	PROPN
cusj-5580	192	10	expires	expire	VERB
cusj-5580	192	11	,	,	PUNCT
cusj-5580	192	12	it	it	PRON
cusj-5580	192	13	would	would	AUX
cusj-5580	192	14	be	be	AUX
cusj-5580	192	15	expected	expect	VERB
cusj-5580	192	16	that	that	SCONJ
cusj-5580	192	17	there	there	PRON
cusj-5580	192	18	will	will	AUX
cusj-5580	192	19	be	be	AUX
cusj-5580	192	20	at	at	ADP
cusj-5580	192	21	least	least	ADJ
cusj-5580	192	22	140,000	140,000	NUM
cusj-5580	192	23	patients	patient	NOUN
cusj-5580	192	24	with	with	ADP
cusj-5580	192	25	cml	cml	PROPN
cusj-5580	192	26	in	in	ADP
cusj-5580	192	27	the	the	DET
cusj-5580	192	28	us	us	PROPN
cusj-5580	192	29	in	in	ADP
cusj-5580	192	30	need	need	NOUN
cusj-5580	192	31	of	of	ADP
cusj-5580	192	32	treatment	treatment	NOUN
cusj-5580	192	33	.	.	PUNCT
cusj-5580	193	1	the	the	DET
cusj-5580	193	2	cost	cost	NOUN
cusj-5580	193	3	on	on	ADP
cusj-5580	193	4	the	the	DET
cusj-5580	193	5	patient	patient	NOUN
cusj-5580	193	6	to	to	PART
cusj-5580	193	7	take	take	VERB
cusj-5580	193	8	tasigna	tasigna	NOUN
cusj-5580	193	9	for	for	ADP
cusj-5580	193	10	one	one	NUM
cusj-5580	193	11	year	year	NOUN
cusj-5580	193	12	is	be	AUX
cusj-5580	193	13	approximately	approximately	ADV
cusj-5580	193	14	$	$	SYM
cusj-5580	193	15	100,000	100,000	NUM
cusj-5580	193	16	,	,	PUNCT
cusj-5580	193	17	highlighting	highlight	VERB
cusj-5580	193	18	the	the	DET
cusj-5580	193	19	importance	importance	NOUN
cusj-5580	193	20	of	of	ADP
cusj-5580	193	21	quickly	quickly	ADV
cusj-5580	193	22	bringing	bring	VERB
cusj-5580	193	23	generic	generic	ADJ
cusj-5580	193	24	versions	version	NOUN
cusj-5580	193	25	of	of	ADP
cusj-5580	193	26	the	the	DET
cusj-5580	193	27	drug	drug	NOUN
cusj-5580	193	28	to	to	AUX
cusj-5580	193	29	market	market	VERB
cusj-5580	193	30	once	once	SCONJ
cusj-5580	193	31	the	the	DET
cusj-5580	193	32	novartis	novartis	PROPN
cusj-5580	193	33	patent	patent	NOUN
cusj-5580	193	34	expires	expire	VERB
cusj-5580	193	35	in	in	ADP
cusj-5580	193	36	order	order	NOUN
cusj-5580	193	37	to	to	PART
cusj-5580	193	38	reduce	reduce	VERB
cusj-5580	193	39	patient	patient	ADJ
cusj-5580	193	40	financial	financial	ADJ
cusj-5580	193	41	burdens	burden	NOUN
cusj-5580	193	42	.	.	PUNCT
cusj-5580	194	1	the	the	DET
cusj-5580	194	2	large	large	ADJ
cusj-5580	194	3	reliance	reliance	NOUN
cusj-5580	194	4	of	of	ADP
cusj-5580	194	5	cml	cml	PROPN
cusj-5580	194	6	patients	patient	NOUN
cusj-5580	194	7	on	on	ADP
cusj-5580	194	8	tki	tki	NOUN
cusj-5580	194	9	drugs	drug	NOUN
cusj-5580	194	10	in	in	ADP
cusj-5580	194	11	addition	addition	NOUN
cusj-5580	194	12	to	to	ADP
cusj-5580	194	13	the	the	DET
cusj-5580	194	14	prohibitively	prohibitively	ADV
cusj-5580	194	15	expensive	expensive	ADJ
cusj-5580	194	16	price	price	NOUN
cusj-5580	194	17	of	of	ADP
cusj-5580	194	18	current	current	ADJ
cusj-5580	194	19	tasigna	tasigna	PROPN
cusj-5580	194	20	treatments	treatment	NOUN
cusj-5580	194	21	highlights	highlight	VERB
cusj-5580	194	22	the	the	DET
cusj-5580	194	23	great	great	ADJ
cusj-5580	194	24	market	market	NOUN
cusj-5580	194	25	potential	potential	NOUN
cusj-5580	194	26	and	and	CCONJ
cusj-5580	194	27	demand	demand	NOUN
cusj-5580	194	28	for	for	ADP
cusj-5580	194	29	developing	develop	VERB
cusj-5580	194	30	a	a	DET
cusj-5580	194	31	generic	generic	ADJ
cusj-5580	194	32	,	,	PUNCT
cusj-5580	194	33	cheaper	cheap	ADJ
cusj-5580	194	34	version	version	NOUN
cusj-5580	194	35	of	of	ADP
cusj-5580	194	36	tasigna	tasigna	PROPN
cusj-5580	194	37	and	and	CCONJ
cusj-5580	194	38	thus	thus	ADV
cusj-5580	194	39	,	,	PUNCT
cusj-5580	194	40	will	will	AUX
cusj-5580	194	41	be	be	AUX
cusj-5580	194	42	the	the	DET
cusj-5580	194	43	focus	focus	NOUN
cusj-5580	194	44	of	of	ADP
cusj-5580	194	45	our	our	PRON
cusj-5580	194	46	investigation	investigation	NOUN
cusj-5580	194	47	.	.	PUNCT
cusj-5580	195	1	figure	figure	NOUN
cusj-5580	195	2	1	1	NUM
cusj-5580	195	3	.	.	PUNCT
cusj-5580	196	1	structure	structure	NOUN
cusj-5580	196	2	of	of	ADP
cusj-5580	196	3	nilotinib	nilotinib	NOUN
cusj-5580	196	4	.	.	PUNCT
cusj-5580	197	1	here	here	ADV
cusj-5580	197	2	,	,	PUNCT
cusj-5580	197	3	we	we	PRON
cusj-5580	197	4	outline	outline	VERB
cusj-5580	197	5	our	our	PRON
cusj-5580	197	6	unique	unique	ADJ
cusj-5580	197	7	process	process	NOUN
cusj-5580	197	8	design	design	NOUN
cusj-5580	197	9	for	for	ADP
cusj-5580	197	10	an	an	DET
cusj-5580	197	11	industrially	industrially	ADV
cusj-5580	197	12	scaled	scale	VERB
cusj-5580	197	13	,	,	PUNCT
cusj-5580	197	14	flow	flow	NOUN
cusj-5580	197	15	-	-	PUNCT
cusj-5580	197	16	based	base	VERB
cusj-5580	197	17	process	process	NOUN
cusj-5580	197	18	for	for	ADP
cusj-5580	197	19	the	the	DET
cusj-5580	197	20	production	production	NOUN
cusj-5580	197	21	of	of	ADP
cusj-5580	197	22	generic	generic	ADJ
cusj-5580	197	23	tasigna	tasigna	PROPN
cusj-5580	197	24	(	(	PUNCT
cusj-5580	197	25	nilotinib	nilotinib	NOUN
cusj-5580	197	26	)	)	PUNCT
cusj-5580	197	27	.	.	PUNCT
cusj-5580	198	1	the	the	DET
cusj-5580	198	2	ultimate	ultimate	ADJ
cusj-5580	198	3	goal	goal	NOUN
cusj-5580	198	4	of	of	ADP
cusj-5580	198	5	this	this	DET
cusj-5580	198	6	investigation	investigation	NOUN
cusj-5580	198	7	will	will	AUX
cusj-5580	198	8	be	be	AUX
cusj-5580	198	9	to	to	PART
cusj-5580	198	10	computationally	computationally	ADV
cusj-5580	198	11	develop	develop	VERB
cusj-5580	198	12	a	a	DET
cusj-5580	198	13	scalable	scalable	ADJ
cusj-5580	198	14	synthesis	synthesis	NOUN
cusj-5580	198	15	which	which	PRON
cusj-5580	198	16	could	could	AUX
cusj-5580	198	17	potentially	potentially	ADV
cusj-5580	198	18	be	be	AUX
cusj-5580	198	19	used	use	VERB
cusj-5580	198	20	to	to	PART
cusj-5580	198	21	produce	produce	VERB
cusj-5580	198	22	large	large	ADJ
cusj-5580	198	23	quantities	quantity	NOUN
cusj-5580	198	24	of	of	ADP
cusj-5580	198	25	nilotinib	nilotinib	NOUN
cusj-5580	198	26	with	with	ADP
cusj-5580	198	27	a	a	DET
cusj-5580	198	28	greater	great	ADJ
cusj-5580	198	29	degree	degree	NOUN
cusj-5580	198	30	of	of	ADP
cusj-5580	198	31	efficiency	efficiency	NOUN
cusj-5580	198	32	than	than	ADP
cusj-5580	198	33	the	the	DET
cusj-5580	198	34	existing	exist	VERB
cusj-5580	198	35	novartis	novartis	NOUN
cusj-5580	198	36	method	method	NOUN
cusj-5580	198	37	.	.	PUNCT
cusj-5580	199	1	thus	thus	ADV
cusj-5580	199	2	,	,	PUNCT
cusj-5580	199	3	once	once	SCONJ
cusj-5580	199	4	the	the	DET
cusj-5580	199	5	novartis	novartis	PROPN
cusj-5580	199	6	patent	patent	NOUN
cusj-5580	199	7	over	over	ADP
cusj-5580	199	8	nilotinib	nilotinib	NOUN
cusj-5580	199	9	production	production	NOUN
cusj-5580	199	10	expires	expire	VERB
cusj-5580	199	11	,	,	PUNCT
cusj-5580	199	12	efficient	efficient	ADJ
cusj-5580	199	13	methods	method	NOUN
cusj-5580	199	14	of	of	ADP
cusj-5580	199	15	producing	produce	VERB
cusj-5580	199	16	generic	generic	ADJ
cusj-5580	199	17	tasigna	tasigna	NOUN
cusj-5580	199	18	can	can	AUX
cusj-5580	199	19	be	be	AUX
cusj-5580	199	20	implemented	implement	VERB
cusj-5580	199	21	to	to	PART
cusj-5580	199	22	rapidly	rapidly	ADV
cusj-5580	199	23	capture	capture	VERB
cusj-5580	199	24	the	the	DET
cusj-5580	199	25	large	large	ADJ
cusj-5580	199	26	and	and	CCONJ
cusj-5580	199	27	profitable	profitable	ADJ
cusj-5580	199	28	market	market	NOUN
cusj-5580	199	29	which	which	PRON
cusj-5580	199	30	tasigna	tasigna	NOUN
cusj-5580	199	31	currently	currently	ADV
cusj-5580	199	32	holds	hold	VERB
cusj-5580	199	33	.	.	PUNCT
cusj-5580	200	1	this	this	PRON
cusj-5580	200	2	will	will	AUX
cusj-5580	200	3	allow	allow	VERB
cusj-5580	200	4	for	for	ADP
cusj-5580	200	5	the	the	DET
cusj-5580	200	6	increased	increase	VERB
cusj-5580	200	7	availability	availability	NOUN
cusj-5580	200	8	and	and	CCONJ
cusj-5580	200	9	lower	low	ADJ
cusj-5580	200	10	price	price	NOUN
cusj-5580	200	11	of	of	ADP
cusj-5580	200	12	a	a	DET
cusj-5580	200	13	much	much	ADV
cusj-5580	200	14	needed	need	VERB
cusj-5580	200	15	drug	drug	NOUN
cusj-5580	200	16	to	to	ADP
cusj-5580	200	17	tens	ten	NOUN
cusj-5580	200	18	of	of	ADP
cusj-5580	200	19	thousands	thousand	NOUN
cusj-5580	200	20	of	of	ADP
cusj-5580	200	21	cml	cml	PROPN
cusj-5580	200	22	patients	patient	NOUN
cusj-5580	200	23	.	.	PUNCT
cusj-5580	201	1	for	for	ADP
cusj-5580	201	2	this	this	DET
cusj-5580	201	3	investigation	investigation	NOUN
cusj-5580	201	4	,	,	PUNCT
cusj-5580	201	5	our	our	PRON
cusj-5580	201	6	team	team	NOUN
cusj-5580	201	7	has	have	AUX
cusj-5580	201	8	taken	take	VERB
cusj-5580	201	9	the	the	DET
cusj-5580	201	10	hypothetical	hypothetical	ADJ
cusj-5580	201	11	role	role	NOUN
cusj-5580	201	12	of	of	ADP
cusj-5580	201	13	a	a	DET
cusj-5580	201	14	generic	generic	ADJ
cusj-5580	201	15	pharmaceutical	pharmaceutical	ADJ
cusj-5580	201	16	company	company	NOUN
cusj-5580	201	17	in	in	ADP
cusj-5580	201	18	planning	plan	VERB
cusj-5580	201	19	the	the	DET
cusj-5580	201	20	development	development	NOUN
cusj-5580	201	21	and	and	CCONJ
cusj-5580	201	22	production	production	NOUN
cusj-5580	201	23	of	of	ADP
cusj-5580	201	24	generic	generic	ADJ
cusj-5580	201	25	tasigna	tasigna	PROPN
cusj-5580	201	26	.	.	PUNCT
cusj-5580	202	1	as	as	ADP
cusj-5580	202	2	such	such	ADJ
cusj-5580	202	3	,	,	PUNCT
cusj-5580	202	4	this	this	DET
cusj-5580	202	5	investigation	investigation	NOUN
cusj-5580	202	6	consists	consist	VERB
cusj-5580	202	7	of	of	ADP
cusj-5580	202	8	four	four	NUM
cusj-5580	202	9	designing	design	VERB
cusj-5580	202	10	an	an	DET
cusj-5580	202	11	industrially	industrially	ADV
cusj-5580	202	12	scalable	scalable	ADJ
cusj-5580	202	13	,	,	PUNCT
cusj-5580	202	14	flow	flow	NOUN
cusj-5580	202	15	-	-	PUNCT
cusj-5580	202	16	based	base	VERB
cusj-5580	202	17	synthesis	synthesis	NOUN
cusj-5580	202	18	for	for	ADP
cusj-5580	202	19	the	the	DET
cusj-5580	202	20	production	production	NOUN
cusj-5580	202	21	of	of	ADP
cusj-5580	202	22	nilotinib	nilotinib	NOUN
cusj-5580	202	23	:	:	PUNCT
cusj-5580	202	24	chemical	chemical	NOUN
cusj-5580	202	25	process	process	NOUN
cusj-5580	202	26	modeling	modeling	NOUN
cusj-5580	202	27	and	and	CCONJ
cusj-5580	202	28	economic	economic	ADJ
cusj-5580	202	29	analysis	analysis	NOUN
cusj-5580	202	30	justin	justin	PROPN
cusj-5580	202	31	m.	m.	PROPN
cusj-5580	202	32	cheung	cheung	PROPN
cusj-5580	202	33	*	*	PROPN
cusj-5580	202	34	,	,	PUNCT
cusj-5580	202	35	jessica	jessica	PROPN
cusj-5580	202	36	hofflich	hofflich	NOUN
cusj-5580	202	37	,	,	PUNCT
cusj-5580	202	38	pablo	pablo	PROPN
cusj-5580	202	39	henriquez	henriquez	PROPN
cusj-5580	202	40	,	,	PUNCT
cusj-5580	202	41	jian	jian	PROPN
cusj-5580	202	42	huang	huang	PROPN
cusj-5580	202	43	,	,	PUNCT
cusj-5580	202	44	and	and	CCONJ
cusj-5580	202	45	nafiul	nafiul	PROPN
cusj-5580	202	46	jami	jami	PROPN
cusj-5580	202	47	department	department	PROPN
cusj-5580	202	48	of	of	ADP
cusj-5580	202	49	materials	material	NOUN
cusj-5580	202	50	science	science	PROPN
cusj-5580	202	51	&	&	CCONJ
cusj-5580	202	52	chemical	chemical	PROPN
cusj-5580	202	53	engineering	engineering	PROPN
cusj-5580	202	54	,	,	PUNCT
cusj-5580	202	55	stony	stony	PROPN
cusj-5580	202	56	brook	brook	PROPN
cusj-5580	202	57	university	university	PROPN
cusj-5580	202	58	cusj	cusj	VERB
cusj-5580	202	59	2019	2019	NUM
cusj-5580	202	60	_	_	PUNCT
cusj-5580	203	1	_	_	PUNCT
cusj-5580	204	1	_	_	PUNCT
cusj-5580	205	1	_	_	PUNCT
cusj-5580	206	1	_	_	PUNCT
cusj-5580	207	1	_	_	PUNCT
cusj-5580	208	1	_	_	PUNCT
cusj-5580	209	1	_	_	PUNCT
cusj-5580	210	1	_	_	PUNCT
cusj-5580	211	1	_	_	PUNCT
cusj-5580	212	1	_	_	PUNCT
cusj-5580	213	1	_	_	PUNCT
cusj-5580	214	1	_	_	PUNCT
cusj-5580	215	1	_	_	PUNCT
cusj-5580	216	1	_	_	PUNCT
cusj-5580	217	1	_	_	PUNCT
cusj-5580	218	1	_	_	PUNCT
cusj-5580	219	1	_	_	PUNCT
cusj-5580	220	1	_	_	PUNCT
cusj-5580	221	1	_	_	PUNCT
cusj-5580	222	1	_	_	PUNCT
cusj-5580	223	1	_	_	PUNCT
cusj-5580	224	1	_	_	PUNCT
cusj-5580	225	1	_	_	PUNCT
cusj-5580	226	1	_	_	PUNCT
cusj-5580	227	1	_	_	PUNCT
cusj-5580	228	1	_	_	PUNCT
cusj-5580	229	1	_	_	PUNCT
cusj-5580	230	1	_	_	PUNCT
cusj-5580	231	1	_	_	PUNCT
cusj-5580	232	1	_	_	PUNCT
cusj-5580	233	1	_	_	PUNCT
cusj-5580	234	1	_	_	PUNCT
cusj-5580	235	1	_	_	PUNCT
cusj-5580	236	1	_	_	PUNCT
cusj-5580	237	1	_	_	PUNCT
cusj-5580	238	1	_	_	PUNCT
cusj-5580	239	1	_	_	PUNCT
cusj-5580	240	1	_	_	PUNCT
cusj-5580	241	1	_	_	PUNCT
cusj-5580	242	1	_	_	PUNCT
cusj-5580	243	1	_	_	PUNCT
cusj-5580	244	1	_	_	PUNCT
cusj-5580	245	1	_	_	PUNCT
cusj-5580	246	1	_	_	PUNCT
cusj-5580	247	1	_	_	PUNCT
cusj-5580	248	1	_	_	PUNCT
cusj-5580	249	1	_	_	PUNCT
cusj-5580	250	1	_	_	PUNCT
cusj-5580	251	1	_	_	PUNCT
cusj-5580	252	1	_	_	PUNCT
cusj-5580	253	1	_	_	PUNCT
cusj-5580	254	1	_	_	PUNCT
cusj-5580	255	1	_	_	PUNCT
cusj-5580	256	1	_	_	PUNCT
cusj-5580	257	1	_	_	PUNCT
cusj-5580	258	1	_	_	PUNCT
cusj-5580	259	1	_	_	PUNCT
cusj-5580	260	1	_	_	PUNCT
cusj-5580	261	1	_	_	PUNCT
cusj-5580	262	1	_	_	PUNCT
cusj-5580	263	1	_	_	PUNCT
cusj-5580	264	1	_	_	PUNCT
cusj-5580	265	1	_	_	PUNCT
cusj-5580	266	1	_	_	PUNCT
cusj-5580	267	1	_	_	PUNCT
cusj-5580	268	1	_	_	PUNCT
cusj-5580	269	1	_	_	PUNCT
cusj-5580	270	1	_	_	PUNCT
cusj-5580	271	1	_	_	PUNCT
cusj-5580	272	1	_	_	PUNCT
cusj-5580	273	1	_	_	PUNCT
cusj-5580	274	1	_	_	PUNCT
cusj-5580	275	1	_	_	PUNCT
cusj-5580	276	1	_	_	PUNCT
cusj-5580	277	1	_	_	PUNCT
cusj-5580	278	1	_	_	PUNCT
cusj-5580	279	1	_	_	PUNCT
cusj-5580	280	1	_	_	PUNCT
cusj-5580	281	1	_	_	PUNCT
cusj-5580	282	1	_	_	PUNCT
cusj-5580	283	1	_	_	PUNCT
cusj-5580	284	1	_	_	PUNCT
cusj-5580	285	1	_	_	PUNCT
cusj-5580	286	1	_	_	PUNCT
cusj-5580	287	1	_	_	PUNCT
cusj-5580	288	1	_	_	PUNCT
cusj-5580	289	1	_	_	PUNCT
cusj-5580	290	1	_	_	PUNCT
cusj-5580	291	1	_	_	PUNCT
cusj-5580	292	1	_	_	PUNCT
cusj-5580	293	1	_	_	PUNCT
cusj-5580	294	1	_	_	PUNCT
cusj-5580	295	1	_	_	PUNCT
cusj-5580	296	1	_	_	PUNCT
cusj-5580	297	1	_	_	PUNCT
cusj-5580	298	1	_	_	PUNCT
cusj-5580	299	1	_	_	PUNCT
cusj-5580	300	1	_	_	PUNCT
cusj-5580	301	1	_	_	PUNCT
cusj-5580	302	1	_	_	PUNCT
cusj-5580	303	1	_	_	PUNCT
cusj-5580	304	1	_	_	PUNCT
cusj-5580	305	1	_	_	PUNCT
cusj-5580	306	1	_	_	PUNCT
cusj-5580	307	1	_	_	PUNCT
cusj-5580	308	1	_	_	PUNCT
cusj-5580	309	1	_	_	PUNCT
cusj-5580	310	1	_	_	PUNCT
cusj-5580	311	1	_	_	PUNCT
cusj-5580	312	1	_	_	PUNCT
cusj-5580	313	1	_	_	PUNCT
cusj-5580	314	1	_	_	PUNCT
cusj-5580	315	1	_	_	PUNCT
cusj-5580	316	1	_	_	PUNCT
cusj-5580	317	1	_	_	PUNCT
cusj-5580	318	1	_	_	PUNCT
cusj-5580	319	1	_	_	PUNCT
cusj-5580	320	1	_	_	PUNCT
cusj-5580	321	1	_	_	PUNCT
cusj-5580	322	1	_	_	PUNCT
cusj-5580	323	1	_	_	PUNCT
cusj-5580	324	1	_	_	PUNCT
cusj-5580	325	1	_	_	PUNCT
cusj-5580	326	1	_	_	PUNCT
cusj-5580	327	1	_	_	PUNCT
cusj-5580	328	1	_	_	PUNCT
cusj-5580	329	1	_	_	PUNCT
cusj-5580	330	1	_	_	PUNCT
cusj-5580	331	1	_	_	PUNCT
cusj-5580	332	1	_	_	PUNCT
cusj-5580	333	1	_	_	PUNCT
cusj-5580	334	1	_	_	PUNCT
cusj-5580	335	1	_	_	PUNCT
cusj-5580	336	1	_	_	PUNCT
cusj-5580	337	1	_	_	PUNCT
cusj-5580	338	1	_	_	PUNCT
cusj-5580	339	1	_	_	PUNCT
cusj-5580	340	1	_	_	PUNCT
cusj-5580	341	1	_	_	PUNCT
cusj-5580	342	1	_	_	PUNCT
cusj-5580	343	1	_	_	PUNCT
cusj-5580	344	1	_	_	PUNCT
cusj-5580	345	1	_	_	PUNCT
cusj-5580	346	1	_	_	PUNCT
cusj-5580	347	1	_	_	PUNCT
cusj-5580	348	1	_	_	PUNCT
cusj-5580	349	1	_	_	PUNCT
cusj-5580	350	1	_	_	PUNCT
cusj-5580	351	1	_	_	PUNCT
cusj-5580	352	1	_	_	PUNCT
cusj-5580	353	1	_	_	PUNCT
cusj-5580	354	1	_	_	PUNCT
cusj-5580	355	1	_	_	PUNCT
cusj-5580	356	1	_	_	PUNCT
cusj-5580	357	1	_	_	PUNCT
cusj-5580	358	1	_	_	PUNCT
cusj-5580	359	1	_	_	PUNCT
cusj-5580	360	1	_	_	PUNCT
cusj-5580	361	1	_	_	PUNCT
cusj-5580	362	1	_	_	PUNCT
cusj-5580	363	1	_	_	PUNCT
cusj-5580	364	1	_	_	PUNCT
cusj-5580	365	1	_	_	PUNCT
cusj-5580	366	1	_	_	PUNCT
cusj-5580	367	1	_	_	PUNCT
cusj-5580	368	1	_	_	PUNCT
cusj-5580	369	1	_	_	PUNCT
cusj-5580	370	1	_	_	PUNCT
cusj-5580	371	1	_	_	PUNCT
cusj-5580	372	1	22	22	NUM
cusj-5580	372	2	distinct	distinct	ADJ
cusj-5580	372	3	sections	section	NOUN
cusj-5580	372	4	:	:	PUNCT
cusj-5580	372	5	(	(	PUNCT
cusj-5580	372	6	1	1	X
cusj-5580	372	7	)	)	PUNCT
cusj-5580	372	8	an	an	DET
cusj-5580	372	9	assessment	assessment	NOUN
cusj-5580	372	10	of	of	ADP
cusj-5580	372	11	the	the	DET
cusj-5580	372	12	commercial	commercial	ADJ
cusj-5580	372	13	efficacy	efficacy	NOUN
cusj-5580	372	14	of	of	ADP
cusj-5580	372	15	novartis	novartis	PROPN
cusj-5580	372	16	’s	’s	PART
cusj-5580	372	17	existing	exist	VERB
cusj-5580	372	18	production	production	NOUN
cusj-5580	372	19	methods	method	NOUN
cusj-5580	372	20	of	of	ADP
cusj-5580	372	21	nilotinib	nilotinib	NOUN
cusj-5580	372	22	,	,	PUNCT
cusj-5580	372	23	(	(	PUNCT
cusj-5580	372	24	2	2	X
cusj-5580	372	25	)	)	PUNCT
cusj-5580	372	26	literature	literature	NOUN
cusj-5580	372	27	review	review	NOUN
cusj-5580	372	28	assessing	assess	VERB
cusj-5580	372	29	the	the	DET
cusj-5580	372	30	efficiency	efficiency	NOUN
cusj-5580	372	31	and	and	CCONJ
cusj-5580	372	32	scalability	scalability	NOUN
cusj-5580	372	33	of	of	ADP
cusj-5580	372	34	existing	exist	VERB
cusj-5580	372	35	,	,	PUNCT
cusj-5580	372	36	laboratory	laboratory	NOUN
cusj-5580	372	37	level	level	NOUN
cusj-5580	372	38	(	(	PUNCT
cusj-5580	372	39	small	small	ADJ
cusj-5580	372	40	scale	scale	NOUN
cusj-5580	372	41	)	)	PUNCT
cusj-5580	372	42	synthesis	synthesis	NOUN
cusj-5580	372	43	methods	method	NOUN
cusj-5580	372	44	of	of	ADP
cusj-5580	372	45	nilotinib	nilotinib	NOUN
cusj-5580	372	46	,	,	PUNCT
cusj-5580	372	47	(	(	PUNCT
cusj-5580	372	48	3	3	X
cusj-5580	372	49	)	)	PUNCT
cusj-5580	372	50	selection	selection	NOUN
cusj-5580	372	51	of	of	ADP
cusj-5580	372	52	an	an	DET
cusj-5580	372	53	existing	exist	VERB
cusj-5580	372	54	small	small	ADJ
cusj-5580	372	55	scale	scale	NOUN
cusj-5580	372	56	nilotinib	nilotinib	NOUN
cusj-5580	372	57	production	production	NOUN
cusj-5580	372	58	process	process	NOUN
cusj-5580	372	59	and	and	CCONJ
cusj-5580	372	60	modeling	model	VERB
cusj-5580	372	61	its	its	PRON
cusj-5580	372	62	scaling	scaling	NOUN
cusj-5580	372	63	to	to	ADP
cusj-5580	372	64	an	an	DET
cusj-5580	372	65	industrial	industrial	ADJ
cusj-5580	372	66	level	level	NOUN
cusj-5580	372	67	using	use	VERB
cusj-5580	372	68	chemcad	chemcad	NOUN
cusj-5580	372	69	software	software	NOUN
cusj-5580	372	70	,	,	PUNCT
cusj-5580	372	71	and	and	CCONJ
cusj-5580	372	72	(	(	PUNCT
cusj-5580	372	73	4	4	X
cusj-5580	372	74	)	)	PUNCT
cusj-5580	372	75	an	an	DET
cusj-5580	372	76	economic	economic	ADJ
cusj-5580	372	77	analysis	analysis	NOUN
cusj-5580	372	78	of	of	ADP
cusj-5580	372	79	the	the	DET
cusj-5580	372	80	scaled	scale	VERB
cusj-5580	372	81	process	process	NOUN
cusj-5580	372	82	to	to	PART
cusj-5580	372	83	assess	assess	VERB
cusj-5580	372	84	its	its	PRON
cusj-5580	372	85	fiscal	fiscal	ADJ
cusj-5580	372	86	viability	viability	NOUN
cusj-5580	372	87	and	and	CCONJ
cusj-5580	372	88	profitability	profitability	NOUN
cusj-5580	372	89	.	.	PUNCT
cusj-5580	373	1	the	the	DET
cusj-5580	373	2	results	result	NOUN
cusj-5580	373	3	of	of	ADP
cusj-5580	373	4	this	this	DET
cusj-5580	373	5	investigation	investigation	NOUN
cusj-5580	373	6	have	have	VERB
cusj-5580	373	7	the	the	DET
cusj-5580	373	8	potential	potential	NOUN
cusj-5580	373	9	to	to	PART
cusj-5580	373	10	provide	provide	VERB
cusj-5580	373	11	a	a	DET
cusj-5580	373	12	robust	robust	ADJ
cusj-5580	373	13	framework	framework	NOUN
cusj-5580	373	14	for	for	ADP
cusj-5580	373	15	the	the	DET
cusj-5580	373	16	large	large	ADJ
cusj-5580	373	17	-	-	PUNCT
cusj-5580	373	18	scale	scale	NOUN
cusj-5580	373	19	development	development	NOUN
cusj-5580	373	20	of	of	ADP
cusj-5580	373	21	nilotinib	nilotinib	NOUN
cusj-5580	373	22	upon	upon	SCONJ
cusj-5580	373	23	the	the	DET
cusj-5580	373	24	expiration	expiration	NOUN
cusj-5580	373	25	of	of	ADP
cusj-5580	373	26	the	the	DET
cusj-5580	373	27	novartis	novartis	PROPN
cusj-5580	373	28	patent	patent	NOUN
cusj-5580	373	29	on	on	ADP
cusj-5580	373	30	tasigna	tasigna	PROPN
cusj-5580	373	31	.	.	PUNCT
cusj-5580	373	32	ii	ii	PROPN
cusj-5580	373	33	.	.	PUNCT
cusj-5580	373	34	methods	method	VERB
cusj-5580	373	35	a	a	DET
cusj-5580	373	36	three	three	NUM
cusj-5580	373	37	-	-	PUNCT
cusj-5580	373	38	stage	stage	NOUN
cusj-5580	373	39	literature	literature	NOUN
cusj-5580	373	40	search	search	NOUN
cusj-5580	373	41	was	be	AUX
cusj-5580	373	42	initially	initially	ADV
cusj-5580	373	43	con	con	PROPN
cusj-5580	373	44	ducted	ducte	VERB
cusj-5580	373	45	to	to	PART
cusj-5580	373	46	address	address	VERB
cusj-5580	373	47	the	the	DET
cusj-5580	373	48	following	follow	VERB
cusj-5580	373	49	goals	goal	NOUN
cusj-5580	373	50	:	:	PUNCT
cusj-5580	373	51	firstly	firstly	ADV
cusj-5580	373	52	,	,	PUNCT
cusj-5580	373	53	market	market	NOUN
cusj-5580	373	54	data	datum	NOUN
cusj-5580	373	55	on	on	ADP
cusj-5580	373	56	nilotinib	nilotinib	NOUN
cusj-5580	373	57	drug	drug	NOUN
cusj-5580	373	58	pricing	pricing	NOUN
cusj-5580	373	59	was	be	AUX
cusj-5580	373	60	collected	collect	VERB
cusj-5580	373	61	in	in	ADP
cusj-5580	373	62	order	order	NOUN
cusj-5580	373	63	to	to	PART
cusj-5580	373	64	develop	develop	VERB
cusj-5580	373	65	robust	robust	ADJ
cusj-5580	373	66	predictions	prediction	NOUN
cusj-5580	373	67	of	of	ADP
cusj-5580	373	68	feasible	feasible	ADJ
cusj-5580	373	69	generic	generic	ADJ
cusj-5580	373	70	pricing	pricing	NOUN
cusj-5580	373	71	patterns	pattern	NOUN
cusj-5580	373	72	as	as	ADV
cusj-5580	373	73	well	well	ADV
cusj-5580	373	74	as	as	ADP
cusj-5580	373	75	market	market	NOUN
cusj-5580	373	76	share	share	NOUN
cusj-5580	373	77	targets	target	NOUN
cusj-5580	373	78	for	for	ADP
cusj-5580	373	79	our	our	PRON
cusj-5580	373	80	given	give	VERB
cusj-5580	373	81	scenario	scenario	NOUN
cusj-5580	373	82	.	.	PUNCT
cusj-5580	374	1	this	this	PRON
cusj-5580	374	2	included	include	VERB
cusj-5580	374	3	a	a	DET
cusj-5580	374	4	comprehensive	comprehensive	ADJ
cusj-5580	374	5	search	search	NOUN
cusj-5580	374	6	of	of	ADP
cusj-5580	374	7	articles	article	NOUN
cusj-5580	374	8	pertaining	pertain	VERB
cusj-5580	374	9	to	to	ADP
cusj-5580	374	10	the	the	DET
cusj-5580	374	11	prevalence	prevalence	NOUN
cusj-5580	374	12	of	of	ADP
cusj-5580	374	13	specific	specific	ADJ
cusj-5580	374	14	tki	tki	NOUN
cusj-5580	374	15	usage	usage	NOUN
cusj-5580	374	16	in	in	ADP
cusj-5580	374	17	cml	cml	PROPN
cusj-5580	374	18	patients	patient	NOUN
cusj-5580	374	19	,	,	PUNCT
cusj-5580	374	20	marketing	marketing	NOUN
cusj-5580	374	21	of	of	ADP
cusj-5580	374	22	each	each	PRON
cusj-5580	374	23	of	of	ADP
cusj-5580	374	24	these	these	DET
cusj-5580	374	25	drugs	drug	NOUN
cusj-5580	374	26	,	,	PUNCT
cusj-5580	374	27	and	and	CCONJ
cusj-5580	374	28	pricing	pricing	NOUN
cusj-5580	374	29	before	before	ADV
cusj-5580	374	30	and	and	CCONJ
cusj-5580	374	31	after	after	ADP
cusj-5580	374	32	generic	generic	ADJ
cusj-5580	374	33	introduction	introduction	NOUN
cusj-5580	374	34	.	.	PUNCT
cusj-5580	375	1	the	the	DET
cusj-5580	375	2	literature	literature	NOUN
cusj-5580	375	3	search	search	NOUN
cusj-5580	375	4	mainly	mainly	ADV
cusj-5580	375	5	utilized	utilize	VERB
cusj-5580	375	6	the	the	DET
cusj-5580	375	7	nci	nci	PROPN
cusj-5580	375	8	(	(	PUNCT
cusj-5580	375	9	national	national	PROPN
cusj-5580	375	10	cancer	cancer	PROPN
cusj-5580	375	11	institute	institute	PROPN
cusj-5580	375	12	)	)	PUNCT
cusj-5580	375	13	database	database	NOUN
cusj-5580	375	14	as	as	ADV
cusj-5580	375	15	well	well	ADV
cusj-5580	375	16	as	as	ADP
cusj-5580	375	17	pharmaceutical	pharmaceutical	ADJ
cusj-5580	375	18	pricing	pricing	NOUN
cusj-5580	375	19	literature	literature	NOUN
cusj-5580	375	20	.	.	PUNCT
cusj-5580	376	1	secondly	secondly	ADV
cusj-5580	376	2	,	,	PUNCT
cusj-5580	376	3	due	due	ADP
cusj-5580	376	4	to	to	ADP
cusj-5580	376	5	the	the	DET
cusj-5580	376	6	lack	lack	NOUN
cusj-5580	376	7	of	of	ADP
cusj-5580	376	8	an	an	DET
cusj-5580	376	9	existing	exist	VERB
cusj-5580	376	10	published	publish	VERB
cusj-5580	376	11	process	process	NOUN
cusj-5580	376	12	flow	flow	NOUN
cusj-5580	376	13	diagram	diagram	NOUN
cusj-5580	376	14	,	,	PUNCT
cusj-5580	376	15	all	all	PRON
cusj-5580	376	16	of	of	ADP
cusj-5580	376	17	novartis	novartis	PROPN
cusj-5580	376	18	’s	’s	PART
cusj-5580	376	19	u.s	u.s	PROPN
cusj-5580	376	20	.	.	PROPN
cusj-5580	376	21	patents	patent	NOUN
cusj-5580	376	22	for	for	ADP
cusj-5580	376	23	the	the	DET
cusj-5580	376	24	production	production	NOUN
cusj-5580	376	25	of	of	ADP
cusj-5580	376	26	tasigna	tasigna	PROPN
cusj-5580	376	27	were	be	AUX
cusj-5580	376	28	collected	collect	VERB
cusj-5580	376	29	and	and	CCONJ
cusj-5580	376	30	a	a	DET
cusj-5580	376	31	predicted	predict	VERB
cusj-5580	376	32	process	process	NOUN
cusj-5580	376	33	flow	flow	NOUN
cusj-5580	376	34	chart	chart	NOUN
cusj-5580	376	35	of	of	ADP
cusj-5580	376	36	novartis	novartis	PROPN
cusj-5580	376	37	’s	’s	PART
cusj-5580	376	38	current	current	ADJ
cusj-5580	376	39	synthesis	synthesis	NOUN
cusj-5580	376	40	method	method	NOUN
cusj-5580	376	41	was	be	AUX
cusj-5580	376	42	constructed	construct	VERB
cusj-5580	376	43	based	base	VERB
cusj-5580	376	44	on	on	ADP
cusj-5580	376	45	the	the	DET
cusj-5580	376	46	claims	claim	NOUN
cusj-5580	376	47	outlined	outline	VERB
cusj-5580	376	48	in	in	ADP
cusj-5580	376	49	their	their	PRON
cusj-5580	376	50	filed	file	VERB
cusj-5580	376	51	patents	patent	NOUN
cusj-5580	376	52	.	.	PUNCT
cusj-5580	377	1	thirdly	thirdly	ADV
cusj-5580	377	2	,	,	PUNCT
cusj-5580	377	3	all	all	DET
cusj-5580	377	4	the	the	DET
cusj-5580	377	5	currently	currently	ADV
cusj-5580	377	6	published	publish	VERB
cusj-5580	377	7	methods	method	NOUN
cusj-5580	377	8	of	of	ADP
cusj-5580	377	9	synthesizing	synthesize	VERB
cusj-5580	377	10	nilotinib	nilotinib	NOUN
cusj-5580	377	11	at	at	ADP
cusj-5580	377	12	any	any	DET
cusj-5580	377	13	scale	scale	NOUN
cusj-5580	377	14	were	be	AUX
cusj-5580	377	15	collected	collect	VERB
cusj-5580	377	16	via	via	ADP
cusj-5580	377	17	literature	literature	NOUN
cusj-5580	377	18	search	search	NOUN
cusj-5580	377	19	and	and	CCONJ
cusj-5580	377	20	analyzed	analyze	VERB
cusj-5580	377	21	for	for	ADP
cusj-5580	377	22	their	their	PRON
cusj-5580	377	23	efficiency	efficiency	NOUN
cusj-5580	377	24	across	across	ADP
cusj-5580	377	25	seven	seven	NUM
cusj-5580	377	26	distinct	distinct	ADJ
cusj-5580	377	27	criteria	criterion	NOUN
cusj-5580	377	28	:	:	PUNCT
cusj-5580	377	29	(	(	PUNCT
cusj-5580	377	30	1	1	X
cusj-5580	377	31	)	)	PUNCT
cusj-5580	377	32	number	number	NOUN
cusj-5580	377	33	of	of	ADP
cusj-5580	377	34	steps	step	NOUN
cusj-5580	377	35	,	,	PUNCT
cusj-5580	377	36	(	(	PUNCT
cusj-5580	377	37	2	2	X
cusj-5580	377	38	)	)	PUNCT
cusj-5580	377	39	reaction	reaction	NOUN
cusj-5580	377	40	temperatures	temperature	NOUN
cusj-5580	377	41	,	,	PUNCT
cusj-5580	377	42	(	(	PUNCT
cusj-5580	377	43	3	3	X
cusj-5580	377	44	)	)	PUNCT
cusj-5580	377	45	reaction	reaction	NOUN
cusj-5580	377	46	pressures	pressure	NOUN
cusj-5580	377	47	,	,	PUNCT
cusj-5580	377	48	(	(	PUNCT
cusj-5580	377	49	4	4	X
cusj-5580	377	50	)	)	PUNCT
cusj-5580	377	51	reaction	reaction	NOUN
cusj-5580	377	52	yields	yield	NOUN
cusj-5580	377	53	,	,	PUNCT
cusj-5580	377	54	(	(	PUNCT
cusj-5580	377	55	5	5	X
cusj-5580	377	56	)	)	PUNCT
cusj-5580	377	57	catalysts	catalyst	NOUN
cusj-5580	377	58	required	require	VERB
cusj-5580	377	59	,	,	PUNCT
cusj-5580	377	60	(	(	PUNCT
cusj-5580	377	61	6	6	X
cusj-5580	377	62	)	)	PUNCT
cusj-5580	377	63	solvents	solvent	NOUN
cusj-5580	377	64	required	require	VERB
cusj-5580	377	65	,	,	PUNCT
cusj-5580	377	66	and	and	CCONJ
cusj-5580	377	67	(	(	PUNCT
cusj-5580	377	68	7	7	X
cusj-5580	377	69	)	)	PUNCT
cusj-5580	377	70	reaction	reaction	NOUN
cusj-5580	377	71	time	time	NOUN
cusj-5580	377	72	.	.	PUNCT
cusj-5580	378	1	once	once	ADV
cusj-5580	378	2	the	the	DET
cusj-5580	378	3	most	most	ADV
cusj-5580	378	4	efficient	efficient	ADJ
cusj-5580	378	5	of	of	ADP
cusj-5580	378	6	these	these	DET
cusj-5580	378	7	methods	method	NOUN
cusj-5580	378	8	was	be	AUX
cusj-5580	378	9	selected	select	VERB
cusj-5580	378	10	,	,	PUNCT
cusj-5580	378	11	process	process	NOUN
cusj-5580	378	12	design	design	NOUN
cusj-5580	378	13	modeling	modeling	NOUN
cusj-5580	378	14	of	of	ADP
cusj-5580	378	15	the	the	DET
cusj-5580	378	16	industrially	industrially	ADV
cusj-5580	378	17	scaled	scale	VERB
cusj-5580	378	18	nilotinib	nilotinib	NOUN
cusj-5580	378	19	synthesis	synthesis	NOUN
cusj-5580	378	20	was	be	AUX
cusj-5580	378	21	conducted	conduct	VERB
cusj-5580	378	22	using	use	VERB
cusj-5580	378	23	chemcad	chemcad	NOUN
cusj-5580	378	24	(	(	PUNCT
cusj-5580	378	25	computer	computer	NOUN
cusj-5580	378	26	-	-	PUNCT
cusj-5580	378	27	aided	aid	VERB
cusj-5580	378	28	design	design	NOUN
cusj-5580	378	29	)	)	PUNCT
cusj-5580	378	30	7	7	NUM
cusj-5580	378	31	software	software	NOUN
cusj-5580	378	32	(	(	PUNCT
cusj-5580	378	33	chemstations	chemstation	NOUN
cusj-5580	378	34	)	)	PUNCT
cusj-5580	378	35	.	.	PUNCT
cusj-5580	379	1	this	this	PRON
cusj-5580	379	2	allowed	allow	VERB
cusj-5580	379	3	for	for	ADP
cusj-5580	379	4	the	the	DET
cusj-5580	379	5	quantitative	quantitative	ADJ
cusj-5580	379	6	assessment	assessment	NOUN
cusj-5580	379	7	and	and	CCONJ
cusj-5580	379	8	control	control	NOUN
cusj-5580	379	9	of	of	ADP
cusj-5580	379	10	large	large	ADJ
cusj-5580	379	11	flow	flow	NOUN
cusj-5580	379	12	rates	rate	NOUN
cusj-5580	379	13	of	of	ADP
cusj-5580	379	14	material	material	NOUN
cusj-5580	379	15	,	,	PUNCT
cusj-5580	379	16	heat	heat	NOUN
cusj-5580	379	17	transfers	transfer	NOUN
cusj-5580	379	18	,	,	PUNCT
cusj-5580	379	19	and	and	CCONJ
cusj-5580	379	20	separation	separation	NOUN
cusj-5580	379	21	efficiencies	efficiency	NOUN
cusj-5580	379	22	,	,	PUNCT
cusj-5580	379	23	allowing	allow	VERB
cusj-5580	379	24	us	we	PRON
cusj-5580	379	25	to	to	PART
cusj-5580	379	26	judge	judge	VERB
cusj-5580	379	27	the	the	DET
cusj-5580	379	28	success	success	NOUN
cusj-5580	379	29	of	of	ADP
cusj-5580	379	30	the	the	DET
cusj-5580	379	31	industrial	industrial	ADJ
cusj-5580	379	32	scaling	scaling	NOUN
cusj-5580	379	33	process	process	NOUN
cusj-5580	379	34	.	.	PUNCT
cusj-5580	380	1	during	during	ADP
cusj-5580	380	2	the	the	DET
cusj-5580	380	3	process	process	NOUN
cusj-5580	380	4	of	of	ADP
cusj-5580	380	5	envisioning	envision	VERB
cusj-5580	380	6	the	the	DET
cusj-5580	380	7	design	design	NOUN
cusj-5580	380	8	through	through	ADP
cusj-5580	380	9	chemcad	chemcad	PROPN
cusj-5580	380	10	,	,	PUNCT
cusj-5580	380	11	special	special	ADJ
cusj-5580	380	12	considerations	consideration	NOUN
cusj-5580	380	13	were	be	AUX
cusj-5580	380	14	made	make	VERB
cusj-5580	380	15	to	to	PART
cusj-5580	380	16	ensure	ensure	VERB
cusj-5580	380	17	that	that	SCONJ
cusj-5580	380	18	the	the	DET
cusj-5580	380	19	process	process	NOUN
cusj-5580	380	20	remained	remain	VERB
cusj-5580	380	21	“	"	PUNCT
cusj-5580	380	22	flow	flow	NOUN
cusj-5580	380	23	-	-	PUNCT
cusj-5580	380	24	based	base	VERB
cusj-5580	380	25	”	"	PUNCT
cusj-5580	380	26	eliminating	eliminate	VERB
cusj-5580	380	27	the	the	DET
cusj-5580	380	28	need	need	NOUN
cusj-5580	380	29	for	for	ADP
cusj-5580	380	30	any	any	DET
cusj-5580	380	31	manual	manual	ADJ
cusj-5580	380	32	handling	handling	NOUN
cusj-5580	380	33	of	of	ADP
cusj-5580	380	34	reaction	reaction	NOUN
cusj-5580	380	35	intermediates	intermediate	NOUN
cusj-5580	380	36	and	and	CCONJ
cusj-5580	380	37	relying	rely	VERB
cusj-5580	380	38	on	on	ADP
cusj-5580	380	39	a	a	DET
cusj-5580	380	40	single	single	ADJ
cusj-5580	380	41	series	series	NOUN
cusj-5580	380	42	of	of	ADP
cusj-5580	380	43	reaction	reaction	NOUN
cusj-5580	380	44	chambers	chamber	NOUN
cusj-5580	380	45	.	.	PUNCT
cusj-5580	381	1	this	this	PRON
cusj-5580	381	2	was	be	AUX
cusj-5580	381	3	achieved	achieve	VERB
cusj-5580	381	4	using	use	VERB
cusj-5580	381	5	packed	packed	ADJ
cusj-5580	381	6	bed	bed	NOUN
cusj-5580	381	7	reactors	reactor	NOUN
cusj-5580	381	8	(	(	PUNCT
cusj-5580	381	9	pbrs	pbrs	NOUN
cusj-5580	381	10	)	)	PUNCT
cusj-5580	381	11	in	in	ADP
cusj-5580	381	12	the	the	DET
cusj-5580	381	13	model	model	NOUN
cusj-5580	381	14	which	which	PRON
cusj-5580	381	15	allow	allow	VERB
cusj-5580	381	16	for	for	ADP
cusj-5580	381	17	connections	connection	NOUN
cusj-5580	381	18	between	between	ADP
cusj-5580	381	19	parallel	parallel	ADJ
cusj-5580	381	20	reactions	reaction	NOUN
cusj-5580	381	21	and	and	CCONJ
cusj-5580	381	22	the	the	DET
cusj-5580	381	23	use	use	NOUN
cusj-5580	381	24	of	of	ADP
cusj-5580	381	25	solid	solid	ADJ
cusj-5580	381	26	catalysts	catalyst	NOUN
cusj-5580	381	27	without	without	ADP
cusj-5580	381	28	the	the	DET
cusj-5580	381	29	need	need	NOUN
cusj-5580	381	30	for	for	ADP
cusj-5580	381	31	interruption	interruption	NOUN
cusj-5580	381	32	of	of	ADP
cusj-5580	381	33	the	the	DET
cusj-5580	381	34	flow	flow	NOUN
cusj-5580	381	35	process	process	NOUN
cusj-5580	381	36	.	.	PUNCT
cusj-5580	382	1	the	the	DET
cusj-5580	382	2	chemcad	chemcad	NOUN
cusj-5580	382	3	software	software	NOUN
cusj-5580	382	4	was	be	AUX
cusj-5580	382	5	also	also	ADV
cusj-5580	382	6	utilized	utilize	VERB
cusj-5580	382	7	to	to	PART
cusj-5580	382	8	verify	verify	VERB
cusj-5580	382	9	that	that	SCONJ
cusj-5580	382	10	the	the	DET
cusj-5580	382	11	proposed	propose	VERB
cusj-5580	382	12	reaction	reaction	NOUN
cusj-5580	382	13	schema	schema	NOUN
cusj-5580	382	14	remained	remain	VERB
cusj-5580	382	15	thermodynamically	thermodynamically	ADV
cusj-5580	382	16	viable	viable	ADJ
cusj-5580	382	17	throughout	throughout	ADV
cusj-5580	382	18	and	and	CCONJ
cusj-5580	382	19	that	that	SCONJ
cusj-5580	382	20	the	the	DET
cusj-5580	382	21	output	output	NOUN
cusj-5580	382	22	products	product	NOUN
cusj-5580	382	23	were	be	AUX
cusj-5580	382	24	high	high	ADJ
cusj-5580	382	25	in	in	ADP
cusj-5580	382	26	purity	purity	NOUN
cusj-5580	382	27	.	.	PUNCT
cusj-5580	383	1	calculations	calculation	NOUN
cusj-5580	383	2	of	of	ADP
cusj-5580	383	3	heat	heat	NOUN
cusj-5580	383	4	and	and	CCONJ
cusj-5580	383	5	material	material	NOUN
cusj-5580	383	6	balances	balance	NOUN
cusj-5580	383	7	done	do	VERB
cusj-5580	383	8	via	via	ADP
cusj-5580	383	9	chemcad	chemcad	NOUN
cusj-5580	383	10	across	across	ADP
cusj-5580	383	11	each	each	DET
cusj-5580	383	12	chemical	chemical	NOUN
cusj-5580	383	13	reaction	reaction	NOUN
cusj-5580	383	14	stage	stage	NOUN
cusj-5580	383	15	ensured	ensure	VERB
cusj-5580	383	16	that	that	SCONJ
cusj-5580	383	17	the	the	DET
cusj-5580	383	18	reactions	reaction	NOUN
cusj-5580	383	19	were	be	AUX
cusj-5580	383	20	well	well	ADV
cusj-5580	383	21	controlled	control	VERB
cusj-5580	383	22	,	,	PUNCT
cusj-5580	383	23	in	in	ADP
cusj-5580	383	24	the	the	DET
cusj-5580	383	25	predicted	predict	VERB
cusj-5580	383	26	state	state	NOUN
cusj-5580	383	27	of	of	ADP
cusj-5580	383	28	matter	matter	NOUN
cusj-5580	383	29	,	,	PUNCT
cusj-5580	383	30	and	and	CCONJ
cusj-5580	383	31	exited	exit	VERB
cusj-5580	383	32	each	each	DET
cusj-5580	383	33	stage	stage	NOUN
cusj-5580	383	34	at	at	ADP
cusj-5580	383	35	the	the	DET
cusj-5580	383	36	appropriate	appropriate	ADJ
cusj-5580	383	37	temperature	temperature	NOUN
cusj-5580	383	38	and	and	CCONJ
cusj-5580	383	39	purity	purity	NOUN
cusj-5580	383	40	.	.	PUNCT
cusj-5580	384	1	lastly	lastly	ADV
cusj-5580	384	2	,	,	PUNCT
cusj-5580	384	3	economic	economic	ADJ
cusj-5580	384	4	analysis	analysis	NOUN
cusj-5580	384	5	incorporated	incorporate	VERB
cusj-5580	384	6	an	an	DET
cusj-5580	384	7	assessment	assessment	NOUN
cusj-5580	384	8	of	of	ADP
cusj-5580	384	9	the	the	DET
cusj-5580	384	10	estimated	estimate	VERB
cusj-5580	384	11	costs	cost	NOUN
cusj-5580	384	12	of	of	ADP
cusj-5580	384	13	running	run	VERB
cusj-5580	384	14	the	the	DET
cusj-5580	384	15	chemical	chemical	NOUN
cusj-5580	384	16	production	production	NOUN
cusj-5580	384	17	facility	facility	NOUN
cusj-5580	384	18	and	and	CCONJ
cusj-5580	384	19	raw	raw	ADJ
cusj-5580	384	20	material	material	NOUN
cusj-5580	384	21	costs	cost	NOUN
cusj-5580	384	22	balanced	balance	VERB
cusj-5580	384	23	against	against	ADP
cusj-5580	384	24	the	the	DET
cusj-5580	384	25	predicted	predict	VERB
cusj-5580	384	26	profits	profit	NOUN
cusj-5580	384	27	of	of	ADP
cusj-5580	384	28	the	the	DET
cusj-5580	384	29	drug	drug	NOUN
cusj-5580	384	30	.	.	PUNCT
cusj-5580	385	1	reactor	reactor	NOUN
cusj-5580	385	2	,	,	PUNCT
cusj-5580	385	3	piping	piping	NOUN
cusj-5580	385	4	,	,	PUNCT
cusj-5580	385	5	and	and	CCONJ
cusj-5580	385	6	distillation	distillation	NOUN
cusj-5580	385	7	tower	tower	NOUN
cusj-5580	385	8	cost	cost	NOUN
cusj-5580	385	9	estimates	estimate	NOUN
cusj-5580	385	10	were	be	AUX
cusj-5580	385	11	made	make	VERB
cusj-5580	385	12	through	through	ADP
cusj-5580	385	13	two	two	NUM
cusj-5580	385	14	american	american	ADJ
cusj-5580	385	15	society	society	NOUN
cusj-5580	385	16	of	of	ADP
cusj-5580	385	17	mechanical	mechanical	ADJ
cusj-5580	385	18	engineers	engineer	NOUN
cusj-5580	385	19	(	(	PUNCT
cusj-5580	385	20	asme	asme	PROPN
cusj-5580	385	21	)	)	PUNCT
cusj-5580	385	22	certified	certified	ADJ
cusj-5580	385	23	reactor	reactor	NOUN
cusj-5580	385	24	manufacturers	manufacturer	NOUN
cusj-5580	385	25	:	:	PUNCT
cusj-5580	385	26	dominion	dominion	NOUN
cusj-5580	385	27	tank	tank	NOUN
cusj-5580	385	28	&	&	CCONJ
cusj-5580	385	29	vessel	vessel	PROPN
cusj-5580	385	30	co.	co.	PROPN
cusj-5580	385	31	,	,	PUNCT
cusj-5580	385	32	inc	inc	PROPN
cusj-5580	385	33	.	.	PROPN
cusj-5580	385	34	based	base	VERB
cusj-5580	385	35	in	in	ADP
cusj-5580	385	36	richmond	richmond	PROPN
cusj-5580	385	37	,	,	PUNCT
cusj-5580	385	38	virginia	virginia	PROPN
cusj-5580	385	39	and	and	CCONJ
cusj-5580	385	40	procedyne	procedyne	PROPN
cusj-5580	385	41	inc	inc	PROPN
cusj-5580	385	42	.	.	PROPN
cusj-5580	385	43	,	,	PUNCT
cusj-5580	385	44	based	base	VERB
cusj-5580	385	45	in	in	ADP
cusj-5580	385	46	new	new	PROPN
cusj-5580	385	47	brunswick	brunswick	PROPN
cusj-5580	385	48	,	,	PUNCT
cusj-5580	385	49	nj	nj	PROPN
cusj-5580	385	50	.	.	PUNCT
cusj-5580	385	51	iii	iii	PROPN
cusj-5580	385	52	.	.	PROPN
cusj-5580	385	53	results	result	NOUN
cusj-5580	385	54	and	and	CCONJ
cusj-5580	385	55	discussion	discussion	NOUN
cusj-5580	385	56	a.	a.	NOUN
cusj-5580	385	57	chemical	chemical	PROPN
cusj-5580	385	58	process	process	NOUN
cusj-5580	385	59	model	model	NOUN
cusj-5580	385	60	design	design	NOUN
cusj-5580	385	61	rationale	rationale	NOUN
cusj-5580	385	62	&	&	CCONJ
cusj-5580	385	63	market	market	NOUN
cusj-5580	385	64	scale	scale	NOUN
cusj-5580	385	65	assessment	assessment	NOUN
cusj-5580	385	66	a	a	DET
cusj-5580	385	67	recent	recent	ADJ
cusj-5580	385	68	study	study	NOUN
cusj-5580	385	69	on	on	ADP
cusj-5580	385	70	patient	patient	PROPN
cusj-5580	385	71	cml	cml	PROPN
cusj-5580	385	72	drug	drug	NOUN
cusj-5580	385	73	preferences	preference	NOUN
cusj-5580	385	74	indicated	indicate	VERB
cusj-5580	385	75	that	that	SCONJ
cusj-5580	385	76	approximately	approximately	ADV
cusj-5580	385	77	20	20	NUM
cusj-5580	385	78	%	%	NOUN
cusj-5580	385	79	of	of	ADP
cusj-5580	385	80	all	all	DET
cusj-5580	385	81	cml	cml	PROPN
cusj-5580	385	82	patients	patient	NOUN
cusj-5580	385	83	take	take	VERB
cusj-5580	385	84	tasigna	tasigna	PROPN
cusj-5580	385	85	(	(	PUNCT
cusj-5580	385	86	nilotinib	nilotinib	NOUN
cusj-5580	385	87	)	)	PUNCT
cusj-5580	385	88	as	as	SCONJ
cusj-5580	385	89	opposed	oppose	VERB
cusj-5580	385	90	to	to	ADP
cusj-5580	385	91	other	other	ADJ
cusj-5580	385	92	tki	tki	X
cusj-5580	385	93	drugs	drug	NOUN
cusj-5580	385	94	(	(	PUNCT
cusj-5580	385	95	sanford	sanford	PROPN
cusj-5580	385	96	et	et	PROPN
cusj-5580	385	97	al	al	PROPN
cusj-5580	385	98	.	.	PROPN
cusj-5580	385	99	,	,	PUNCT
cusj-5580	385	100	2014	2014	NUM
cusj-5580	385	101	)	)	PUNCT
cusj-5580	385	102	.	.	PUNCT
cusj-5580	386	1	assuming	assume	VERB
cusj-5580	386	2	that	that	SCONJ
cusj-5580	386	3	this	this	DET
cusj-5580	386	4	trend	trend	NOUN
cusj-5580	386	5	continues	continue	VERB
cusj-5580	386	6	,	,	PUNCT
cusj-5580	386	7	we	we	PRON
cusj-5580	386	8	can	can	AUX
cusj-5580	386	9	predict	predict	VERB
cusj-5580	386	10	that	that	SCONJ
cusj-5580	386	11	the	the	DET
cusj-5580	386	12	total	total	ADJ
cusj-5580	386	13	cml	cml	PROPN
cusj-5580	386	14	patient	patient	ADJ
cusj-5580	386	15	pool	pool	NOUN
cusj-5580	386	16	taking	take	VERB
cusj-5580	386	17	nilotinib	nilotinib	NOUN
cusj-5580	386	18	by	by	ADP
cusj-5580	386	19	the	the	DET
cusj-5580	386	20	year	year	NOUN
cusj-5580	386	21	2023	2023	NUM
cusj-5580	386	22	is	be	AUX
cusj-5580	386	23	approximately	approximately	ADV
cusj-5580	386	24	28,000	28,000	NUM
cusj-5580	386	25	individuals	individual	NOUN
cusj-5580	386	26	.	.	PUNCT
cusj-5580	387	1	based	base	VERB
cusj-5580	387	2	on	on	ADP
cusj-5580	387	3	historical	historical	ADJ
cusj-5580	387	4	precedent	precedent	NOUN
cusj-5580	387	5	,	,	PUNCT
cusj-5580	387	6	as	as	ADP
cusj-5580	387	7	an	an	DET
cusj-5580	387	8	emerging	emerge	VERB
cusj-5580	387	9	generic	generic	ADJ
cusj-5580	387	10	pharmaceutical	pharmaceutical	ADJ
cusj-5580	387	11	company	company	NOUN
cusj-5580	387	12	,	,	PUNCT
cusj-5580	387	13	our	our	PRON
cusj-5580	387	14	goal	goal	NOUN
cusj-5580	387	15	would	would	AUX
cusj-5580	387	16	be	be	AUX
cusj-5580	387	17	to	to	PART
cusj-5580	387	18	capture	capture	VERB
cusj-5580	387	19	approximately	approximately	ADV
cusj-5580	387	20	15	15	NUM
cusj-5580	387	21	%	%	NOUN
cusj-5580	387	22	of	of	ADP
cusj-5580	387	23	the	the	DET
cusj-5580	387	24	nilotinib	nilotinib	NOUN
cusj-5580	387	25	market	market	NOUN
cusj-5580	387	26	share	share	NOUN
cusj-5580	387	27	in	in	ADP
cusj-5580	387	28	the	the	DET
cusj-5580	387	29	us	us	PROPN
cusj-5580	387	30	,	,	PUNCT
cusj-5580	387	31	translating	translate	VERB
cusj-5580	387	32	to	to	ADP
cusj-5580	387	33	about	about	ADV
cusj-5580	387	34	4200	4200	NUM
cusj-5580	387	35	patients	patient	NOUN
cusj-5580	387	36	.	.	PUNCT
cusj-5580	388	1	the	the	DET
cusj-5580	388	2	food	food	NOUN
cusj-5580	388	3	and	and	CCONJ
cusj-5580	388	4	drug	drug	PROPN
cusj-5580	388	5	administration	administration	PROPN
cusj-5580	388	6	(	(	PUNCT
cusj-5580	388	7	fda	fda	PROPN
cusj-5580	388	8	)	)	PUNCT
cusj-5580	388	9	approved	approve	VERB
cusj-5580	388	10	regimen	regiman	NOUN
cusj-5580	388	11	for	for	ADP
cusj-5580	388	12	treatment	treatment	NOUN
cusj-5580	388	13	of	of	ADP
cusj-5580	388	14	cml	cml	PROPN
cusj-5580	388	15	with	with	ADP
cusj-5580	388	16	nilotinib	nilotinib	NOUN
cusj-5580	388	17	requires	require	VERB
cusj-5580	388	18	a	a	DET
cusj-5580	388	19	dose	dose	NOUN
cusj-5580	388	20	of	of	ADP
cusj-5580	388	21	0.3	0.3	NUM
cusj-5580	388	22	mg	mg	NOUN
cusj-5580	388	23	twice	twice	ADV
cusj-5580	388	24	daily	daily	ADJ
cusj-5580	388	25	(	(	PUNCT
cusj-5580	388	26	or	or	CCONJ
cusj-5580	388	27	approximately	approximately	ADV
cusj-5580	388	28	230	230	NUM
cusj-5580	388	29	g	g	NOUN
cusj-5580	388	30	of	of	ADP
cusj-5580	388	31	nilotinib	nilotinib	NOUN
cusj-5580	388	32	per	per	ADP
cusj-5580	388	33	patient	patient	NOUN
cusj-5580	388	34	per	per	ADP
cusj-5580	388	35	year	year	NOUN
cusj-5580	388	36	)	)	PUNCT
cusj-5580	388	37	(	(	PUNCT
cusj-5580	388	38	national	national	PROPN
cusj-5580	388	39	cancer	cancer	PROPN
cusj-5580	388	40	institute	institute	PROPN
cusj-5580	388	41	,	,	PUNCT
cusj-5580	388	42	2013	2013	NUM
cusj-5580	388	43	)	)	PUNCT
cusj-5580	388	44	.	.	PUNCT
cusj-5580	389	1	thus	thus	ADV
cusj-5580	389	2	,	,	PUNCT
cusj-5580	389	3	if	if	SCONJ
cusj-5580	389	4	we	we	PRON
cusj-5580	389	5	wish	wish	VERB
cusj-5580	389	6	to	to	PART
cusj-5580	389	7	pursue	pursue	VERB
cusj-5580	389	8	15	15	NUM
cusj-5580	389	9	%	%	NOUN
cusj-5580	389	10	of	of	ADP
cusj-5580	389	11	the	the	DET
cusj-5580	389	12	nilotinib	nilotinib	NOUN
cusj-5580	389	13	market	market	NOUN
cusj-5580	389	14	share	share	NOUN
cusj-5580	389	15	,	,	PUNCT
cusj-5580	389	16	production	production	NOUN
cusj-5580	389	17	of	of	ADP
cusj-5580	389	18	at	at	ADV
cusj-5580	389	19	least	least	ADV
cusj-5580	389	20	1150	1150	NUM
cusj-5580	389	21	kg	kg	NOUN
cusj-5580	389	22	nilotinib	nilotinib	NOUN
cusj-5580	389	23	/	/	SYM
cusj-5580	389	24	year	year	NOUN
cusj-5580	389	25	is	be	AUX
cusj-5580	389	26	the	the	DET
cusj-5580	389	27	ultimate	ultimate	ADJ
cusj-5580	389	28	goal	goal	NOUN
cusj-5580	389	29	.	.	PUNCT
cusj-5580	390	1	the	the	DET
cusj-5580	390	2	current	current	ADJ
cusj-5580	390	3	market	market	NOUN
cusj-5580	390	4	price	price	NOUN
cusj-5580	390	5	of	of	ADP
cusj-5580	390	6	tasigna	tasigna	PROPN
cusj-5580	390	7	is	be	AUX
cusj-5580	390	8	~$600	~$600	X
cusj-5580	390	9	per	per	X
cusj-5580	390	10	gram	gram	NOUN
cusj-5580	390	11	(	(	PUNCT
cusj-5580	390	12	or	or	CCONJ
cusj-5580	390	13	$	$	SYM
cusj-5580	390	14	600,000	600,000	NUM
cusj-5580	390	15	per	per	ADP
cusj-5580	390	16	kg	kg	NOUN
cusj-5580	390	17	)	)	PUNCT
cusj-5580	390	18	.	.	PUNCT
cusj-5580	391	1	at	at	ADP
cusj-5580	391	2	current	current	ADJ
cusj-5580	391	3	pricing	pricing	NOUN
cusj-5580	391	4	,	,	PUNCT
cusj-5580	391	5	the	the	DET
cusj-5580	391	6	estimated	estimate	VERB
cusj-5580	391	7	profit	profit	NOUN
cusj-5580	391	8	for	for	ADP
cusj-5580	391	9	1150	1150	NUM
cusj-5580	391	10	kg	kg	NOUN
cusj-5580	391	11	/	/	SYM
cusj-5580	391	12	year	year	NOUN
cusj-5580	391	13	of	of	ADP
cusj-5580	391	14	is	be	AUX
cusj-5580	391	15	$	$	SYM
cusj-5580	391	16	690	690	NUM
cusj-5580	391	17	million	million	NUM
cusj-5580	391	18	/	/	SYM
cusj-5580	391	19	year	year	NOUN
cusj-5580	391	20	.	.	PUNCT
cusj-5580	392	1	however	however	ADV
cusj-5580	392	2	,	,	PUNCT
cusj-5580	392	3	once	once	SCONJ
cusj-5580	392	4	nilotinib	nilotinib	NOUN
cusj-5580	392	5	comes	come	VERB
cusj-5580	392	6	off	off	ADP
cusj-5580	392	7	patent	patent	NOUN
cusj-5580	392	8	and	and	CCONJ
cusj-5580	392	9	is	be	AUX
cusj-5580	392	10	generically	generically	ADV
cusj-5580	392	11	produced	produce	VERB
cusj-5580	392	12	,	,	PUNCT
cusj-5580	392	13	we	we	PRON
cusj-5580	392	14	can	can	AUX
cusj-5580	392	15	expect	expect	VERB
cusj-5580	392	16	a	a	DET
cusj-5580	392	17	sharp	sharp	ADJ
cusj-5580	392	18	price	price	NOUN
cusj-5580	392	19	drop	drop	NOUN
cusj-5580	392	20	.	.	PUNCT
cusj-5580	393	1	we	we	PRON
cusj-5580	393	2	developed	develop	VERB
cusj-5580	393	3	our	our	PRON
cusj-5580	393	4	estimates	estimate	NOUN
cusj-5580	393	5	of	of	ADP
cusj-5580	393	6	this	this	DET
cusj-5580	393	7	change	change	NOUN
cusj-5580	393	8	based	base	VERB
cusj-5580	393	9	on	on	ADP
cusj-5580	393	10	the	the	DET
cusj-5580	393	11	price	price	NOUN
cusj-5580	393	12	drop	drop	NOUN
cusj-5580	393	13	that	that	PRON
cusj-5580	393	14	gleevec	gleevec	PROPN
cusj-5580	393	15	(	(	PUNCT
cusj-5580	393	16	the	the	DET
cusj-5580	393	17	1st	1st	ADJ
cusj-5580	393	18	generation	generation	NOUN
cusj-5580	393	19	version	version	NOUN
cusj-5580	393	20	of	of	ADP
cusj-5580	393	21	tasigna	tasigna	PROPN
cusj-5580	393	22	)	)	PUNCT
cusj-5580	393	23	underwent	underwent	NOUN
cusj-5580	393	24	when	when	SCONJ
cusj-5580	393	25	it	it	PRON
cusj-5580	393	26	came	come	VERB
cusj-5580	393	27	off	off	ADP
cusj-5580	393	28	patent	patent	NOUN
cusj-5580	393	29	.	.	PUNCT
cusj-5580	394	1	in	in	ADP
cusj-5580	394	2	2016	2016	NUM
cusj-5580	394	3	,	,	PUNCT
cusj-5580	394	4	gleevec	gleevec	PROPN
cusj-5580	394	5	cost	cost	VERB
cusj-5580	394	6	~$146,000	~$146,000	NUM
cusj-5580	394	7	/	/	SYM
cusj-5580	394	8	year	year	NOUN
cusj-5580	394	9	.	.	PUNCT
cusj-5580	395	1	since	since	SCONJ
cusj-5580	395	2	coming	come	VERB
cusj-5580	395	3	off	off	ADP
cusj-5580	395	4	patent	patent	NOUN
cusj-5580	395	5	,	,	PUNCT
cusj-5580	395	6	the	the	DET
cusj-5580	395	7	cheapest	cheap	ADJ
cusj-5580	395	8	generic	generic	ADJ
cusj-5580	395	9	gleevec	gleevec	NOUN
cusj-5580	395	10	option	option	NOUN
cusj-5580	395	11	is	be	AUX
cusj-5580	395	12	~$57,000	~$57,000	NUM
cusj-5580	395	13	/	/	SYM
cusj-5580	395	14	year	year	NOUN
cusj-5580	395	15	(	(	PUNCT
cusj-5580	395	16	kantarjian	kantarjian	NOUN
cusj-5580	395	17	,	,	PUNCT
cusj-5580	395	18	2016	2016	NUM
cusj-5580	395	19	)	)	PUNCT
cusj-5580	395	20	.	.	PUNCT
cusj-5580	396	1	this	this	PRON
cusj-5580	396	2	is	be	AUX
cusj-5580	396	3	a	a	DET
cusj-5580	396	4	60	60	NUM
cusj-5580	396	5	%	%	NOUN
cusj-5580	396	6	decrease	decrease	NOUN
cusj-5580	396	7	in	in	ADP
cusj-5580	396	8	price	price	NOUN
cusj-5580	396	9	from	from	ADP
cusj-5580	396	10	original	original	ADJ
cusj-5580	396	11	to	to	ADP
cusj-5580	396	12	generic	generic	ADJ
cusj-5580	396	13	form	form	NOUN
cusj-5580	396	14	of	of	ADP
cusj-5580	396	15	the	the	DET
cusj-5580	396	16	first	first	ADJ
cusj-5580	396	17	generation	generation	NOUN
cusj-5580	396	18	tki	tki	X
cusj-5580	396	19	drug	drug	NOUN
cusj-5580	396	20	.	.	PUNCT
cusj-5580	397	1	we	we	PRON
cusj-5580	397	2	will	will	AUX
cusj-5580	397	3	assume	assume	VERB
cusj-5580	397	4	that	that	SCONJ
cusj-5580	397	5	this	this	DET
cusj-5580	397	6	pattern	pattern	NOUN
cusj-5580	397	7	(	(	PUNCT
cusj-5580	397	8	60	60	NUM
cusj-5580	397	9	%	%	NOUN
cusj-5580	397	10	drop	drop	NOUN
cusj-5580	397	11	in	in	ADP
cusj-5580	397	12	price	price	NOUN
cusj-5580	397	13	)	)	PUNCT
cusj-5580	397	14	will	will	AUX
cusj-5580	397	15	also	also	ADV
cusj-5580	397	16	hold	hold	VERB
cusj-5580	397	17	for	for	ADP
cusj-5580	397	18	tasigna	tasigna	PROPN
cusj-5580	397	19	/	/	SYM
cusj-5580	397	20	nilotinib	nilotinib	NOUN
cusj-5580	397	21	,	,	PUNCT
cusj-5580	397	22	therefore	therefore	ADV
cusj-5580	397	23	,	,	PUNCT
cusj-5580	397	24	we	we	PRON
cusj-5580	397	25	can	can	AUX
cusj-5580	397	26	assume	assume	VERB
cusj-5580	397	27	that	that	SCONJ
cusj-5580	397	28	tasigna	tasigna	PROPN
cusj-5580	397	29	’s	’s	PART
cusj-5580	397	30	generic	generic	PROPN
cusj-5580	397	31	will	will	AUX
cusj-5580	397	32	be	be	AUX
cusj-5580	397	33	priced	price	VERB
cusj-5580	397	34	at	at	ADP
cusj-5580	397	35	$	$	SYM
cusj-5580	397	36	240	240	NUM
cusj-5580	397	37	per	per	ADP
cusj-5580	397	38	gram	gram	NOUN
cusj-5580	397	39	and	and	CCONJ
cusj-5580	397	40	that	that	SCONJ
cusj-5580	397	41	the	the	DET
cusj-5580	397	42	estimated	estimate	VERB
cusj-5580	397	43	revenue	revenue	NOUN
cusj-5580	397	44	for	for	ADP
cusj-5580	397	45	1150	1150	NUM
cusj-5580	397	46	kg	kg	NOUN
cusj-5580	397	47	/	/	SYM
cusj-5580	397	48	year	year	NOUN
cusj-5580	397	49	nilotinib	nilotinib	NOUN
cusj-5580	397	50	production	production	NOUN
cusj-5580	397	51	is	be	AUX
cusj-5580	397	52	$	$	SYM
cusj-5580	397	53	276	276	NUM
cusj-5580	397	54	million	million	NUM
cusj-5580	397	55	/	/	SYM
cusj-5580	397	56	year	year	NOUN
cusj-5580	397	57	.	.	PUNCT
cusj-5580	398	1	in	in	ADP
cusj-5580	398	2	summary	summary	NOUN
cusj-5580	398	3	,	,	PUNCT
cusj-5580	398	4	our	our	PRON
cusj-5580	398	5	generic	generic	ADJ
cusj-5580	398	6	pharmaceutical	pharmaceutical	ADJ
cusj-5580	398	7	company	company	NOUN
cusj-5580	398	8	will	will	AUX
cusj-5580	398	9	aim	aim	VERB
cusj-5580	398	10	to	to	PART
cusj-5580	398	11	take	take	VERB
cusj-5580	398	12	15	15	NUM
cusj-5580	398	13	%	%	NOUN
cusj-5580	398	14	of	of	ADP
cusj-5580	398	15	the	the	DET
cusj-5580	398	16	nilotinib	nilotinib	NOUN
cusj-5580	398	17	market	market	NOUN
cusj-5580	398	18	share	share	NOUN
cusj-5580	398	19	when	when	SCONJ
cusj-5580	398	20	the	the	DET
cusj-5580	398	21	drug	drug	NOUN
cusj-5580	398	22	comes	come	VERB
cusj-5580	398	23	off	off	ADP
cusj-5580	398	24	patent	patent	NOUN
cusj-5580	398	25	in	in	ADP
cusj-5580	398	26	2023	2023	NUM
cusj-5580	398	27	,	,	PUNCT
cusj-5580	398	28	equating	equate	VERB
cusj-5580	398	29	to	to	ADP
cusj-5580	398	30	about	about	ADP
cusj-5580	398	31	4200	4200	NUM
cusj-5580	398	32	patients	patient	NOUN
cusj-5580	398	33	.	.	PUNCT
cusj-5580	399	1	to	to	PART
cusj-5580	399	2	meet	meet	VERB
cusj-5580	399	3	this	this	DET
cusj-5580	399	4	demand	demand	NOUN
cusj-5580	399	5	,	,	PUNCT
cusj-5580	399	6	our	our	PRON
cusj-5580	399	7	goal	goal	NOUN
cusj-5580	399	8	is	be	AUX
cusj-5580	399	9	to	to	PART
cusj-5580	399	10	design	design	VERB
cusj-5580	399	11	a	a	DET
cusj-5580	399	12	chemical	chemical	NOUN
cusj-5580	399	13	process	process	NOUN
cusj-5580	399	14	for	for	ADP
cusj-5580	399	15	nilotinib	nilotinib	NOUN
cusj-5580	399	16	production	production	NOUN
cusj-5580	399	17	with	with	ADP
cusj-5580	399	18	a	a	DET
cusj-5580	399	19	minimum	minimum	ADJ
cusj-5580	399	20	capacity	capacity	NOUN
cusj-5580	399	21	of	of	ADP
cusj-5580	399	22	1150	1150	NUM
cusj-5580	399	23	kg	kg	NOUN
cusj-5580	399	24	per	per	ADP
cusj-5580	399	25	year	year	NOUN
cusj-5580	399	26	.	.	PUNCT
cusj-5580	400	1	given	give	VERB
cusj-5580	400	2	,	,	PUNCT
cusj-5580	400	3	an	an	DET
cusj-5580	400	4	expected	expect	VERB
cusj-5580	400	5	60	60	NUM
cusj-5580	400	6	%	%	NOUN
cusj-5580	400	7	lower	low	ADJ
cusj-5580	400	8	price	price	NOUN
cusj-5580	400	9	of	of	ADP
cusj-5580	400	10	generic	generic	ADJ
cusj-5580	400	11	,	,	PUNCT
cusj-5580	400	12	the	the	DET
cusj-5580	400	13	cost	cost	NOUN
cusj-5580	400	14	of	of	ADP
cusj-5580	400	15	our	our	PRON
cusj-5580	400	16	generic	generic	ADJ
cusj-5580	400	17	nilotinib	nilotinib	NOUN
cusj-5580	400	18	will	will	AUX
cusj-5580	400	19	be	be	AUX
cusj-5580	400	20	~$240	~$240	NOUN
cusj-5580	400	21	/	/	SYM
cusj-5580	400	22	gram	gram	NOUN
cusj-5580	400	23	and	and	CCONJ
cusj-5580	400	24	our	our	PRON
cusj-5580	400	25	total	total	ADJ
cusj-5580	400	26	yearly	yearly	ADJ
cusj-5580	400	27	revenue	revenue	NOUN
cusj-5580	400	28	is	be	AUX
cusj-5580	400	29	predicted	predict	VERB
cusj-5580	400	30	to	to	PART
cusj-5580	400	31	be	be	AUX
cusj-5580	400	32	$	$	SYM
cusj-5580	400	33	276	276	NUM
cusj-5580	400	34	million	million	NUM
cusj-5580	400	35	.	.	PUNCT
cusj-5580	401	1	_	_	PUNCT
cusj-5580	402	1	_	_	PUNCT
cusj-5580	403	1	_	_	PUNCT
cusj-5580	404	1	_	_	PUNCT
cusj-5580	405	1	_	_	PUNCT
cusj-5580	406	1	_	_	PUNCT
cusj-5580	407	1	_	_	PUNCT
cusj-5580	408	1	_	_	PUNCT
cusj-5580	409	1	_	_	PUNCT
cusj-5580	410	1	_	_	PUNCT
cusj-5580	411	1	_	_	PUNCT
cusj-5580	412	1	_	_	PUNCT
cusj-5580	413	1	_	_	PUNCT
cusj-5580	414	1	_	_	PUNCT
cusj-5580	415	1	_	_	PUNCT
cusj-5580	416	1	_	_	PUNCT
cusj-5580	417	1	_	_	PUNCT
cusj-5580	418	1	_	_	PUNCT
cusj-5580	419	1	_	_	PUNCT
cusj-5580	420	1	_	_	PUNCT
cusj-5580	421	1	_	_	PUNCT
cusj-5580	422	1	_	_	PUNCT
cusj-5580	423	1	_	_	PUNCT
cusj-5580	424	1	_	_	PUNCT
cusj-5580	425	1	_	_	PUNCT
cusj-5580	426	1	_	_	PUNCT
cusj-5580	427	1	_	_	PUNCT
cusj-5580	428	1	_	_	PUNCT
cusj-5580	429	1	_	_	PUNCT
cusj-5580	430	1	_	_	PUNCT
cusj-5580	431	1	_	_	PUNCT
cusj-5580	432	1	_	_	PUNCT
cusj-5580	433	1	_	_	PUNCT
cusj-5580	434	1	_	_	PUNCT
cusj-5580	435	1	_	_	PUNCT
cusj-5580	436	1	_	_	PUNCT
cusj-5580	437	1	_	_	PUNCT
cusj-5580	438	1	_	_	PUNCT
cusj-5580	439	1	_	_	PUNCT
cusj-5580	440	1	_	_	PUNCT
cusj-5580	441	1	_	_	PUNCT
cusj-5580	442	1	_	_	PUNCT
cusj-5580	443	1	_	_	PUNCT
cusj-5580	444	1	_	_	PUNCT
cusj-5580	445	1	_	_	PUNCT
cusj-5580	446	1	_	_	PUNCT
cusj-5580	447	1	_	_	PUNCT
cusj-5580	448	1	_	_	PUNCT
cusj-5580	449	1	_	_	PUNCT
cusj-5580	450	1	_	_	PUNCT
cusj-5580	451	1	_	_	PUNCT
cusj-5580	452	1	_	_	PUNCT
cusj-5580	453	1	_	_	PUNCT
cusj-5580	454	1	_	_	PUNCT
cusj-5580	455	1	_	_	PUNCT
cusj-5580	456	1	_	_	PUNCT
cusj-5580	457	1	_	_	PUNCT
cusj-5580	458	1	_	_	PUNCT
cusj-5580	459	1	_	_	PUNCT
cusj-5580	460	1	_	_	PUNCT
cusj-5580	461	1	_	_	PUNCT
cusj-5580	462	1	_	_	PUNCT
cusj-5580	463	1	_	_	PUNCT
cusj-5580	464	1	_	_	PUNCT
cusj-5580	465	1	_	_	PUNCT
cusj-5580	466	1	_	_	PUNCT
cusj-5580	467	1	_	_	PUNCT
cusj-5580	468	1	_	_	PUNCT
cusj-5580	469	1	_	_	PUNCT
cusj-5580	470	1	_	_	PUNCT
cusj-5580	471	1	_	_	PUNCT
cusj-5580	472	1	_	_	PUNCT
cusj-5580	473	1	_	_	PUNCT
cusj-5580	474	1	_	_	PUNCT
cusj-5580	475	1	_	_	PUNCT
cusj-5580	476	1	_	_	PUNCT
cusj-5580	477	1	_	_	PUNCT
cusj-5580	478	1	_	_	PUNCT
cusj-5580	479	1	_	_	PUNCT
cusj-5580	480	1	_	_	PUNCT
cusj-5580	480	2	cusj	cusj	VERB
cusj-5580	480	3	2019	2019	NUM
cusj-5580	480	4	_	_	PUNCT
cusj-5580	481	1	_	_	PUNCT
cusj-5580	482	1	_	_	PUNCT
cusj-5580	483	1	_	_	PUNCT
cusj-5580	484	1	_	_	PUNCT
cusj-5580	485	1	_	_	PUNCT
cusj-5580	486	1	_	_	PUNCT
cusj-5580	487	1	_	_	PUNCT
cusj-5580	488	1	_	_	PUNCT
cusj-5580	489	1	_	_	PUNCT
cusj-5580	490	1	_	_	PUNCT
cusj-5580	491	1	_	_	PUNCT
cusj-5580	492	1	_	_	PUNCT
cusj-5580	493	1	_	_	PUNCT
cusj-5580	494	1	_	_	PUNCT
cusj-5580	495	1	_	_	PUNCT
cusj-5580	496	1	_	_	PUNCT
cusj-5580	497	1	_	_	PUNCT
cusj-5580	498	1	_	_	PUNCT
cusj-5580	499	1	_	_	PUNCT
cusj-5580	500	1	_	_	PUNCT
cusj-5580	501	1	_	_	PUNCT
cusj-5580	502	1	_	_	PUNCT
cusj-5580	503	1	_	_	PUNCT
cusj-5580	504	1	_	_	PUNCT
cusj-5580	505	1	_	_	PUNCT
cusj-5580	506	1	_	_	PUNCT
cusj-5580	507	1	_	_	PUNCT
cusj-5580	508	1	_	_	PUNCT
cusj-5580	509	1	_	_	PUNCT
cusj-5580	510	1	_	_	PUNCT
cusj-5580	511	1	_	_	PUNCT
cusj-5580	512	1	_	_	PUNCT
cusj-5580	513	1	_	_	PUNCT
cusj-5580	514	1	_	_	PUNCT
cusj-5580	515	1	_	_	PUNCT
cusj-5580	516	1	_	_	PUNCT
cusj-5580	517	1	_	_	PUNCT
cusj-5580	518	1	_	_	PUNCT
cusj-5580	519	1	_	_	PUNCT
cusj-5580	520	1	_	_	PUNCT
cusj-5580	521	1	_	_	PUNCT
cusj-5580	522	1	_	_	PUNCT
cusj-5580	523	1	_	_	PUNCT
cusj-5580	524	1	_	_	PUNCT
cusj-5580	525	1	_	_	PUNCT
cusj-5580	526	1	_	_	PUNCT
cusj-5580	527	1	_	_	PUNCT
cusj-5580	528	1	_	_	PUNCT
cusj-5580	529	1	_	_	PUNCT
cusj-5580	530	1	_	_	PUNCT
cusj-5580	531	1	_	_	PUNCT
cusj-5580	532	1	_	_	PUNCT
cusj-5580	533	1	_	_	PUNCT
cusj-5580	534	1	_	_	PUNCT
cusj-5580	535	1	_	_	PUNCT
cusj-5580	536	1	_	_	PUNCT
cusj-5580	537	1	_	_	PUNCT
cusj-5580	538	1	_	_	PUNCT
cusj-5580	539	1	_	_	PUNCT
cusj-5580	540	1	_	_	PUNCT
cusj-5580	541	1	_	_	PUNCT
cusj-5580	542	1	_	_	PUNCT
cusj-5580	543	1	_	_	PUNCT
cusj-5580	544	1	_	_	PUNCT
cusj-5580	545	1	_	_	PUNCT
cusj-5580	546	1	_	_	PUNCT
cusj-5580	547	1	_	_	PUNCT
cusj-5580	548	1	_	_	PUNCT
cusj-5580	549	1	_	_	PUNCT
cusj-5580	550	1	_	_	PUNCT
cusj-5580	551	1	_	_	PUNCT
cusj-5580	552	1	_	_	PUNCT
cusj-5580	553	1	_	_	PUNCT
cusj-5580	554	1	_	_	PUNCT
cusj-5580	555	1	_	_	PUNCT
cusj-5580	556	1	_	_	PUNCT
cusj-5580	557	1	_	_	PUNCT
cusj-5580	558	1	_	_	PUNCT
cusj-5580	559	1	_	_	PUNCT
cusj-5580	560	1	_	_	PUNCT
cusj-5580	561	1	_	_	PUNCT
cusj-5580	562	1	_	_	PUNCT
cusj-5580	563	1	_	_	PUNCT
cusj-5580	564	1	_	_	PUNCT
cusj-5580	565	1	_	_	PUNCT
cusj-5580	566	1	_	_	PUNCT
cusj-5580	567	1	_	_	PUNCT
cusj-5580	568	1	_	_	PUNCT
cusj-5580	569	1	_	_	PUNCT
cusj-5580	570	1	23	23	NUM
cusj-5580	570	2	critical	critical	ADJ
cusj-5580	570	3	assessment	assessment	NOUN
cusj-5580	570	4	of	of	ADP
cusj-5580	570	5	the	the	DET
cusj-5580	570	6	novartis	novartis	NOUN
cusj-5580	570	7	synthesis	synthesis	NOUN
cusj-5580	570	8	for	for	ADP
cusj-5580	570	9	nilotinib	nilotinib	NOUN
cusj-5580	570	10	novartis	novartis	PROPN
cusj-5580	570	11	has	have	AUX
cusj-5580	570	12	not	not	PART
cusj-5580	570	13	made	make	VERB
cusj-5580	570	14	a	a	DET
cusj-5580	570	15	process	process	NOUN
cusj-5580	570	16	flow	flow	NOUN
cusj-5580	570	17	sheet	sheet	NOUN
cusj-5580	570	18	for	for	ADP
cusj-5580	570	19	its	its	PRON
cusj-5580	570	20	synthesis	synthesis	NOUN
cusj-5580	570	21	of	of	ADP
cusj-5580	570	22	nilotinib	nilotinib	NOUN
cusj-5580	570	23	publicly	publicly	ADV
cusj-5580	570	24	available	available	ADJ
cusj-5580	570	25	.	.	PUNCT
cusj-5580	571	1	to	to	PART
cusj-5580	571	2	circumvent	circumvent	VERB
cusj-5580	571	3	this	this	PRON
cusj-5580	571	4	,	,	PUNCT
cusj-5580	571	5	our	our	PRON
cusj-5580	571	6	team	team	NOUN
cusj-5580	571	7	has	have	AUX
cusj-5580	571	8	utilized	utilize	VERB
cusj-5580	571	9	the	the	DET
cusj-5580	571	10	steps	step	NOUN
cusj-5580	571	11	outlined	outline	VERB
cusj-5580	571	12	in	in	ADP
cusj-5580	571	13	novartis	novartis	PROPN
cusj-5580	571	14	’s	’s	PART
cusj-5580	571	15	patent	patent	NOUN
cusj-5580	571	16	to	to	PART
cusj-5580	571	17	create	create	VERB
cusj-5580	571	18	our	our	PRON
cusj-5580	571	19	own	own	ADJ
cusj-5580	571	20	process	process	NOUN
cusj-5580	571	21	flow	flow	NOUN
cusj-5580	571	22	sheet	sheet	NOUN
cusj-5580	571	23	of	of	ADP
cusj-5580	571	24	the	the	DET
cusj-5580	571	25	novartis	novartis	NOUN
cusj-5580	571	26	synthesis	synthesis	NOUN
cusj-5580	571	27	shown	show	VERB
cusj-5580	571	28	in	in	ADP
cusj-5580	571	29	fig	fig	NOUN
cusj-5580	571	30	.	.	PUNCT
cusj-5580	572	1	2	2	NUM
cusj-5580	572	2	(	(	PUNCT
cusj-5580	572	3	breitenstein	breitenstein	NOUN
cusj-5580	572	4	et	et	PROPN
cusj-5580	572	5	al	al	PROPN
cusj-5580	572	6	.	.	PROPN
cusj-5580	572	7	,	,	PUNCT
cusj-5580	572	8	2004	2004	NUM
cusj-5580	572	9	)	)	PUNCT
cusj-5580	572	10	.	.	PUNCT
cusj-5580	573	1	fig	fig	NOUN
cusj-5580	573	2	.	.	PUNCT
cusj-5580	574	1	2	2	NUM
cusj-5580	574	2	overviews	overview	NOUN
cusj-5580	574	3	novartis	novartis	NOUN
cusj-5580	574	4	’s	’s	PART
cusj-5580	574	5	patented	patent	VERB
cusj-5580	574	6	process	process	NOUN
cusj-5580	574	7	chemistry	chemistry	NOUN
cusj-5580	574	8	for	for	ADP
cusj-5580	574	9	the	the	DET
cusj-5580	574	10	synthesis	synthesis	NOUN
cusj-5580	574	11	of	of	ADP
cusj-5580	574	12	nilotinib	nilotinib	NOUN
cusj-5580	574	13	which	which	PRON
cusj-5580	574	14	is	be	AUX
cusj-5580	574	15	currently	currently	ADV
cusj-5580	574	16	used	use	VERB
cusj-5580	574	17	for	for	ADP
cusj-5580	574	18	the	the	DET
cusj-5580	574	19	industrial	industrial	ADJ
cusj-5580	574	20	production	production	NOUN
cusj-5580	574	21	of	of	ADP
cusj-5580	574	22	tasigna	tasigna	PROPN
cusj-5580	574	23	(	(	PUNCT
cusj-5580	574	24	deadman	deadman	PROPN
cusj-5580	574	25	et	et	PROPN
cusj-5580	574	26	al	al	PROPN
cusj-5580	574	27	.	.	PROPN
cusj-5580	574	28	,	,	PUNCT
cusj-5580	574	29	2013	2013	NUM
cusj-5580	574	30	)	)	PUNCT
cusj-5580	574	31	.	.	PUNCT
cusj-5580	575	1	from	from	ADP
cusj-5580	575	2	the	the	DET
cusj-5580	575	3	process	process	NOUN
cusj-5580	575	4	flow	flow	NOUN
cusj-5580	575	5	diagram	diagram	NOUN
cusj-5580	575	6	,	,	PUNCT
cusj-5580	575	7	it	it	PRON
cusj-5580	575	8	can	can	AUX
cusj-5580	575	9	be	be	AUX
cusj-5580	575	10	seen	see	VERB
cusj-5580	575	11	that	that	SCONJ
cusj-5580	575	12	the	the	DET
cusj-5580	575	13	production	production	NOUN
cusj-5580	575	14	of	of	ADP
cusj-5580	575	15	nilotinib	nilotinib	NOUN
cusj-5580	575	16	consists	consist	VERB
cusj-5580	575	17	of	of	ADP
cusj-5580	575	18	three	three	NUM
cusj-5580	575	19	main	main	ADJ
cusj-5580	575	20	parts	part	NOUN
cusj-5580	575	21	.	.	PUNCT
cusj-5580	576	1	the	the	DET
cusj-5580	576	2	first	first	ADJ
cusj-5580	576	3	part	part	NOUN
cusj-5580	576	4	(	(	PUNCT
cusj-5580	576	5	the	the	DET
cusj-5580	576	6	top	top	ADJ
cusj-5580	576	7	portion	portion	NOUN
cusj-5580	576	8	of	of	ADP
cusj-5580	576	9	the	the	DET
cusj-5580	576	10	reaction	reaction	NOUN
cusj-5580	576	11	scheme	scheme	NOUN
cusj-5580	576	12	)	)	PUNCT
cusj-5580	576	13	is	be	AUX
cusj-5580	576	14	required	require	VERB
cusj-5580	576	15	to	to	PART
cusj-5580	576	16	produce	produce	VERB
cusj-5580	576	17	the	the	DET
cusj-5580	576	18	carbon	carbon	NOUN
cusj-5580	576	19	-	-	PUNCT
cusj-5580	576	20	nitrogen	nitrogen	NOUN
cusj-5580	576	21	bond	bond	NOUN
cusj-5580	576	22	(	(	PUNCT
cusj-5580	576	23	fig	fig	NOUN
cusj-5580	576	24	.	.	PUNCT
cusj-5580	577	1	2	2	NUM
cusj-5580	577	2	)	)	PUNCT
cusj-5580	577	3	.	.	PUNCT
cusj-5580	578	1	the	the	DET
cusj-5580	578	2	second	second	ADJ
cusj-5580	578	3	part	part	NOUN
cusj-5580	578	4	is	be	AUX
cusj-5580	578	5	the	the	DET
cusj-5580	578	6	nucleophilic	nucleophilic	ADJ
cusj-5580	578	7	substitution	substitution	NOUN
cusj-5580	578	8	which	which	PRON
cusj-5580	578	9	occurs	occur	VERB
cusj-5580	578	10	concurrently	concurrently	ADV
cusj-5580	578	11	to	to	PART
cusj-5580	578	12	produce	produce	VERB
cusj-5580	578	13	the	the	DET
cusj-5580	578	14	required	require	VERB
cusj-5580	578	15	inter	inter	ADJ
cusj-5580	578	16	mediate	mediate	NOUN
cusj-5580	578	17	in	in	ADP
cusj-5580	578	18	the	the	DET
cusj-5580	578	19	bottom	bottom	ADJ
cusj-5580	578	20	portion	portion	NOUN
cusj-5580	578	21	of	of	ADP
cusj-5580	578	22	the	the	DET
cusj-5580	578	23	reaction	reaction	NOUN
cusj-5580	578	24	scheme	scheme	NOUN
cusj-5580	578	25	(	(	PUNCT
cusj-5580	578	26	fig	fig	NOUN
cusj-5580	578	27	.	.	PUNCT
cusj-5580	579	1	2	2	NUM
cusj-5580	579	2	)	)	PUNCT
cusj-5580	579	3	.	.	PUNCT
cusj-5580	580	1	with	with	SCONJ
cusj-5580	580	2	both	both	DET
cusj-5580	580	3	parts	part	NOUN
cusj-5580	580	4	completed	complete	VERB
cusj-5580	580	5	,	,	PUNCT
cusj-5580	580	6	the	the	DET
cusj-5580	580	7	third	third	ADJ
cusj-5580	580	8	and	and	CCONJ
cusj-5580	580	9	final	final	ADJ
cusj-5580	580	10	amide	amide	NOUN
cusj-5580	580	11	formation	formation	NOUN
cusj-5580	580	12	occurs	occur	VERB
cusj-5580	580	13	during	during	ADP
cusj-5580	580	14	the	the	DET
cusj-5580	580	15	last	last	ADJ
cusj-5580	580	16	synthesis	synthesis	NOUN
cusj-5580	580	17	step	step	NOUN
cusj-5580	580	18	to	to	ADP
cusj-5580	580	19	nilotinib	nilotinib	NOUN
cusj-5580	580	20	formation	formation	NOUN
cusj-5580	580	21	(	(	PUNCT
cusj-5580	580	22	fig	fig	NOUN
cusj-5580	580	23	.	.	PUNCT
cusj-5580	581	1	2	2	NUM
cusj-5580	581	2	)	)	PUNCT
cusj-5580	581	3	.	.	PUNCT
cusj-5580	582	1	although	although	SCONJ
cusj-5580	582	2	this	this	DET
cusj-5580	582	3	process	process	NOUN
cusj-5580	582	4	chemistry	chemistry	NOUN
cusj-5580	582	5	for	for	ADP
cusj-5580	582	6	nilotinib	nilotinib	NOUN
cusj-5580	582	7	synthesis	synthesis	NOUN
cusj-5580	582	8	is	be	AUX
cusj-5580	582	9	currently	currently	ADV
cusj-5580	582	10	in	in	ADP
cusj-5580	582	11	use	use	NOUN
cusj-5580	582	12	for	for	ADP
cusj-5580	582	13	its	its	PRON
cusj-5580	582	14	commercial	commercial	ADJ
cusj-5580	582	15	production	production	NOUN
cusj-5580	582	16	,	,	PUNCT
cusj-5580	582	17	there	there	PRON
cusj-5580	582	18	are	be	VERB
cusj-5580	582	19	four	four	NUM
cusj-5580	582	20	distinct	distinct	ADJ
cusj-5580	582	21	drawbacks	drawback	NOUN
cusj-5580	582	22	of	of	ADP
cusj-5580	582	23	novartis	novartis	NOUN
cusj-5580	582	24	’s	’s	PART
cusj-5580	582	25	currently	currently	ADV
cusj-5580	582	26	patented	patent	VERB
cusj-5580	582	27	method	method	NOUN
cusj-5580	582	28	.	.	PUNCT
cusj-5580	583	1	(	(	PUNCT
cusj-5580	583	2	1	1	X
cusj-5580	583	3	)	)	PUNCT
cusj-5580	583	4	during	during	ADP
cusj-5580	583	5	the	the	DET
cusj-5580	583	6	production	production	NOUN
cusj-5580	583	7	of	of	ADP
cusj-5580	583	8	the	the	DET
cusj-5580	583	9	intermediate	intermediate	ADJ
cusj-5580	583	10	at	at	ADP
cusj-5580	583	11	the	the	DET
cusj-5580	583	12	top	top	NOUN
cusj-5580	583	13	of	of	ADP
cusj-5580	583	14	the	the	DET
cusj-5580	583	15	reaction	reaction	NOUN
cusj-5580	583	16	scheme	scheme	NOUN
cusj-5580	583	17	(	(	PUNCT
cusj-5580	583	18	fig	fig	NOUN
cusj-5580	583	19	.	.	PUNCT
cusj-5580	584	1	2	2	NUM
cusj-5580	584	2	)	)	PUNCT
cusj-5580	584	3	,	,	PUNCT
cusj-5580	584	4	the	the	DET
cusj-5580	584	5	use	use	NOUN
cusj-5580	584	6	of	of	ADP
cusj-5580	584	7	nucleophilic	nucleophilic	ADJ
cusj-5580	584	8	substitution	substitution	NOUN
cusj-5580	584	9	allows	allow	VERB
cusj-5580	584	10	for	for	ADP
cusj-5580	584	11	the	the	DET
cusj-5580	584	12	possible	possible	ADJ
cusj-5580	584	13	formation	formation	NOUN
cusj-5580	584	14	of	of	ADP
cusj-5580	584	15	two	two	NUM
cusj-5580	584	16	intermediate	intermediate	ADJ
cusj-5580	584	17	isomers	isomer	NOUN
cusj-5580	584	18	.	.	PUNCT
cusj-5580	585	1	the	the	DET
cusj-5580	585	2	formation	formation	NOUN
cusj-5580	585	3	of	of	ADP
cusj-5580	585	4	these	these	DET
cusj-5580	585	5	two	two	NUM
cusj-5580	585	6	distinct	distinct	ADJ
cusj-5580	585	7	isomers	isomer	NOUN
cusj-5580	585	8	means	mean	VERB
cusj-5580	585	9	that	that	SCONJ
cusj-5580	585	10	regioselectivity	regioselectivity	NOUN
cusj-5580	585	11	of	of	ADP
cusj-5580	585	12	the	the	DET
cusj-5580	585	13	reaction	reaction	NOUN
cusj-5580	585	14	becomes	become	VERB
cusj-5580	585	15	a	a	DET
cusj-5580	585	16	great	great	ADJ
cusj-5580	585	17	challenge	challenge	NOUN
cusj-5580	585	18	since	since	SCONJ
cusj-5580	585	19	only	only	ADV
cusj-5580	585	20	one	one	NUM
cusj-5580	585	21	of	of	ADP
cusj-5580	585	22	thregioisomers	thregioisomer	NOUN
cusj-5580	585	23	is	be	AUX
cusj-5580	585	24	desired	desire	VERB
cusj-5580	585	25	(	(	PUNCT
cusj-5580	585	26	deadman	deadman	PROPN
cusj-5580	585	27	et	et	PROPN
cusj-5580	585	28	al	al	PROPN
cusj-5580	585	29	.	.	PROPN
cusj-5580	585	30	,	,	PUNCT
cusj-5580	585	31	2013	2013	NUM
cusj-5580	585	32	)	)	PUNCT
cusj-5580	585	33	.	.	PUNCT
cusj-5580	586	1	as	as	ADP
cusj-5580	586	2	such	such	ADJ
cusj-5580	586	3	,	,	PUNCT
cusj-5580	586	4	this	this	PRON
cusj-5580	586	5	would	would	AUX
cusj-5580	586	6	mean	mean	VERB
cusj-5580	586	7	that	that	SCONJ
cusj-5580	586	8	novartis	novartis	PROPN
cusj-5580	586	9	’s	’s	PART
cusj-5580	586	10	non	non	ADJ
cusj-5580	586	11	-	-	ADJ
cusj-5580	586	12	regioselective	regioselective	ADJ
cusj-5580	586	13	method	method	NOUN
cusj-5580	586	14	for	for	ADP
cusj-5580	586	15	the	the	DET
cusj-5580	586	16	synthesis	synthesis	NOUN
cusj-5580	586	17	of	of	ADP
cusj-5580	586	18	this	this	DET
cusj-5580	586	19	particular	particular	ADJ
cusj-5580	586	20	intermediate	intermediate	NOUN
cusj-5580	586	21	would	would	AUX
cusj-5580	586	22	require	require	VERB
cusj-5580	586	23	a	a	DET
cusj-5580	586	24	great	great	ADJ
cusj-5580	586	25	deal	deal	NOUN
cusj-5580	586	26	of	of	ADP
cusj-5580	586	27	subsequent	subsequent	ADJ
cusj-5580	586	28	separation	separation	NOUN
cusj-5580	586	29	and	and	CCONJ
cusj-5580	586	30	purification	purification	NOUN
cusj-5580	586	31	to	to	PART
cusj-5580	586	32	obtain	obtain	VERB
cusj-5580	586	33	only	only	ADV
cusj-5580	586	34	the	the	DET
cusj-5580	586	35	desired	desire	VERB
cusj-5580	586	36	regioisomer	regioisomer	NOUN
cusj-5580	586	37	,	,	PUNCT
cusj-5580	586	38	steps	step	NOUN
cusj-5580	586	39	that	that	PRON
cusj-5580	586	40	diminish	diminish	VERB
cusj-5580	586	41	efficiency	efficiency	NOUN
cusj-5580	586	42	and	and	CCONJ
cusj-5580	586	43	induce	induce	VERB
cusj-5580	586	44	great	great	ADJ
cusj-5580	586	45	time	time	NOUN
cusj-5580	586	46	and	and	CCONJ
cusj-5580	586	47	monetary	monetary	ADJ
cusj-5580	586	48	penalties	penalty	NOUN
cusj-5580	586	49	on	on	ADP
cusj-5580	586	50	the	the	DET
cusj-5580	586	51	production	production	NOUN
cusj-5580	586	52	process	process	NOUN
cusj-5580	586	53	.	.	PUNCT
cusj-5580	587	1	(	(	PUNCT
cusj-5580	587	2	2	2	NUM
cusj-5580	587	3	)	)	PUNCT
cusj-5580	587	4	from	from	ADP
cusj-5580	587	5	fig	fig	NOUN
cusj-5580	587	6	.	.	PUNCT
cusj-5580	588	1	2	2	NUM
cusj-5580	588	2	it	it	PRON
cusj-5580	588	3	is	be	AUX
cusj-5580	588	4	evident	evident	ADJ
cusj-5580	588	5	that	that	SCONJ
cusj-5580	588	6	the	the	DET
cusj-5580	588	7	entirety	entirety	NOUN
cusj-5580	588	8	of	of	ADP
cusj-5580	588	9	the	the	DET
cusj-5580	588	10	novartis	novartis	NOUN
cusj-5580	588	11	synthesis	synthesis	NOUN
cusj-5580	588	12	is	be	AUX
cusj-5580	588	13	an	an	DET
cusj-5580	588	14	extremely	extremely	ADV
cusj-5580	588	15	lengthy	lengthy	ADJ
cusj-5580	588	16	multi	multi	ADJ
cusj-5580	588	17	-	-	ADJ
cusj-5580	588	18	stage	stage	NOUN
cusj-5580	588	19	process	process	NOUN
cusj-5580	588	20	.	.	PUNCT
cusj-5580	589	1	for	for	ADP
cusj-5580	589	2	instance	instance	NOUN
cusj-5580	589	3	,	,	PUNCT
cusj-5580	589	4	the	the	DET
cusj-5580	589	5	reflux	reflux	NOUN
cusj-5580	589	6	stage	stage	NOUN
cusj-5580	589	7	of	of	ADP
cusj-5580	589	8	the	the	DET
cusj-5580	589	9	reaction	reaction	NOUN
cusj-5580	589	10	takes	take	VERB
cusj-5580	589	11	over	over	ADP
cusj-5580	590	1	68	68	NUM
cusj-5580	590	2	hours	hour	NOUN
cusj-5580	590	3	,	,	PUNCT
cusj-5580	590	4	alone	alone	ADV
cusj-5580	590	5	.	.	PUNCT
cusj-5580	591	1	(	(	PUNCT
cusj-5580	591	2	3	3	X
cusj-5580	591	3	)	)	PUNCT
cusj-5580	591	4	the	the	DET
cusj-5580	591	5	process	process	NOUN
cusj-5580	591	6	’s	’s	PART
cusj-5580	591	7	use	use	NOUN
cusj-5580	591	8	of	of	ADP
cusj-5580	591	9	multi	multi	ADJ
cusj-5580	591	10	-	-	ADJ
cusj-5580	591	11	stage	stage	NOUN
cusj-5580	591	12	batch	batch	NOUN
cusj-5580	591	13	reactors	reactor	NOUN
cusj-5580	591	14	is	be	AUX
cusj-5580	591	15	highly	highly	ADV
cusj-5580	591	16	unfavorable	unfavorable	ADJ
cusj-5580	591	17	due	due	ADP
cusj-5580	591	18	to	to	ADP
cusj-5580	591	19	the	the	DET
cusj-5580	591	20	time	time	NOUN
cusj-5580	591	21	-	-	PUNCT
cusj-5580	591	22	consuming	consume	VERB
cusj-5580	591	23	transfer	transfer	NOUN
cusj-5580	591	24	requirements	requirement	NOUN
cusj-5580	591	25	that	that	PRON
cusj-5580	591	26	will	will	AUX
cusj-5580	591	27	inevitably	inevitably	ADV
cusj-5580	591	28	also	also	ADV
cusj-5580	591	29	require	require	VERB
cusj-5580	591	30	a	a	DET
cusj-5580	591	31	great	great	ADJ
cusj-5580	591	32	deal	deal	NOUN
cusj-5580	591	33	of	of	ADP
cusj-5580	591	34	manpower	manpower	NOUN
cusj-5580	591	35	,	,	PUNCT
cusj-5580	591	36	further	far	ADV
cusj-5580	591	37	prolonging	prolong	VERB
cusj-5580	591	38	the	the	DET
cusj-5580	591	39	total	total	ADJ
cusj-5580	591	40	length	length	NOUN
cusj-5580	591	41	of	of	ADP
cusj-5580	591	42	the	the	DET
cusj-5580	591	43	reaction	reaction	NOUN
cusj-5580	591	44	.	.	PUNCT
cusj-5580	592	1	in	in	ADP
cusj-5580	592	2	addition	addition	NOUN
cusj-5580	592	3	,	,	PUNCT
cusj-5580	592	4	separation	separation	NOUN
cusj-5580	592	5	procedures	procedure	NOUN
cusj-5580	592	6	such	such	ADJ
cusj-5580	592	7	as	as	ADP
cusj-5580	592	8	evaporation	evaporation	NOUN
cusj-5580	592	9	and	and	CCONJ
cusj-5580	592	10	filtration	filtration	NOUN
cusj-5580	592	11	will	will	AUX
cusj-5580	592	12	likely	likely	ADV
cusj-5580	592	13	have	have	VERB
cusj-5580	592	14	to	to	PART
cusj-5580	592	15	be	be	AUX
cusj-5580	592	16	applied	apply	VERB
cusj-5580	592	17	after	after	ADP
cusj-5580	592	18	each	each	DET
cusj-5580	592	19	batch	batch	NOUN
cusj-5580	592	20	reaction	reaction	NOUN
cusj-5580	592	21	since	since	SCONJ
cusj-5580	592	22	solvent	solvent	ADJ
cusj-5580	592	23	switching	switching	NOUN
cusj-5580	592	24	will	will	AUX
cusj-5580	592	25	be	be	AUX
cusj-5580	592	26	required	require	VERB
cusj-5580	592	27	.	.	PUNCT
cusj-5580	593	1	these	these	DET
cusj-5580	593	2	separation	separation	NOUN
cusj-5580	593	3	techniques	technique	NOUN
cusj-5580	593	4	will	will	AUX
cusj-5580	593	5	be	be	AUX
cusj-5580	593	6	clumsy	clumsy	ADJ
cusj-5580	593	7	and	and	CCONJ
cusj-5580	593	8	greatly	greatly	ADV
cusj-5580	593	9	reduce	reduce	VERB
cusj-5580	593	10	the	the	DET
cusj-5580	593	11	degree	degree	NOUN
cusj-5580	593	12	of	of	ADP
cusj-5580	593	13	process	process	NOUN
cusj-5580	593	14	control	control	NOUN
cusj-5580	593	15	over	over	ADP
cusj-5580	593	16	the	the	DET
cusj-5580	593	17	reaction	reaction	NOUN
cusj-5580	593	18	.	.	PUNCT
cusj-5580	594	1	(	(	PUNCT
cusj-5580	594	2	4	4	NUM
cusj-5580	594	3	)	)	PUNCT
cusj-5580	594	4	from	from	ADP
cusj-5580	594	5	a	a	DET
cusj-5580	594	6	hazard	hazard	NOUN
cusj-5580	594	7	and	and	CCONJ
cusj-5580	594	8	operability	operability	NOUN
cusj-5580	594	9	(	(	PUNCT
cusj-5580	594	10	hazop	hazop	NOUN
cusj-5580	594	11	)	)	PUNCT
cusj-5580	594	12	stand	stand	VERB
cusj-5580	594	13	point	point	NOUN
cusj-5580	594	14	,	,	PUNCT
cusj-5580	594	15	the	the	DET
cusj-5580	594	16	overall	overall	ADJ
cusj-5580	594	17	novartis	novartis	NOUN
cusj-5580	594	18	synthesis	synthesis	NOUN
cusj-5580	594	19	is	be	AUX
cusj-5580	594	20	particularly	particularly	ADV
cusj-5580	594	21	dangerous	dangerous	ADJ
cusj-5580	594	22	as	as	SCONJ
cusj-5580	594	23	it	it	PRON
cusj-5580	594	24	requires	require	VERB
cusj-5580	594	25	many	many	ADJ
cusj-5580	594	26	steps	step	NOUN
cusj-5580	594	27	and	and	CCONJ
cusj-5580	594	28	solvents	solvent	NOUN
cusj-5580	594	29	.	.	PUNCT
cusj-5580	595	1	this	this	PRON
cusj-5580	595	2	presents	present	VERB
cusj-5580	595	3	a	a	DET
cusj-5580	595	4	concern	concern	NOUN
cusj-5580	595	5	for	for	ADP
cusj-5580	595	6	health	health	NOUN
cusj-5580	595	7	and	and	CCONJ
cusj-5580	595	8	safety	safety	NOUN
cusj-5580	595	9	,	,	PUNCT
cusj-5580	595	10	particularly	particularly	ADV
cusj-5580	595	11	since	since	SCONJ
cusj-5580	595	12	the	the	DET
cusj-5580	595	13	use	use	NOUN
cusj-5580	595	14	of	of	ADP
cusj-5580	595	15	multi	multi	ADJ
cusj-5580	595	16	-	-	ADJ
cusj-5580	595	17	stage	stage	NOUN
cusj-5580	595	18	batch	batch	NOUN
cusj-5580	595	19	reactor	reactor	NOUN
cusj-5580	595	20	processes	process	NOUN
cusj-5580	595	21	will	will	AUX
cusj-5580	595	22	create	create	VERB
cusj-5580	595	23	a	a	DET
cusj-5580	595	24	large	large	ADJ
cusj-5580	595	25	degree	degree	NOUN
cusj-5580	595	26	of	of	ADP
cusj-5580	595	27	exposure	exposure	NOUN
cusj-5580	595	28	risk	risk	NOUN
cusj-5580	595	29	to	to	ADP
cusj-5580	595	30	chemical	chemical	ADJ
cusj-5580	595	31	plant	plant	NOUN
cusj-5580	595	32	workers	worker	NOUN
cusj-5580	595	33	who	who	PRON
cusj-5580	595	34	will	will	AUX
cusj-5580	595	35	have	have	VERB
cusj-5580	595	36	to	to	PART
cusj-5580	595	37	directly	directly	ADV
cusj-5580	595	38	deal	deal	VERB
cusj-5580	595	39	with	with	ADP
cusj-5580	595	40	carcinogenic	carcinogenic	ADJ
cusj-5580	595	41	solvents	solvent	NOUN
cusj-5580	595	42	such	such	ADJ
cusj-5580	595	43	as	as	ADP
cusj-5580	595	44	dioxane	dioxane	NOUN
cusj-5580	595	45	and	and	CCONJ
cusj-5580	595	46	toluene	toluene	NOUN
cusj-5580	595	47	during	during	ADP
cusj-5580	595	48	mass	mass	ADJ
cusj-5580	595	49	transfer	transfer	NOUN
cusj-5580	595	50	operations	operation	NOUN
cusj-5580	595	51	.	.	PUNCT
cusj-5580	596	1	while	while	SCONJ
cusj-5580	596	2	novartis	novartis	PROPN
cusj-5580	596	3	does	do	AUX
cusj-5580	596	4	not	not	PART
cusj-5580	596	5	publicly	publicly	ADV
cusj-5580	596	6	disclose	disclose	VERB
cusj-5580	596	7	their	their	PRON
cusj-5580	596	8	production	production	NOUN
cusj-5580	596	9	processes	process	NOUN
cusj-5580	596	10	,	,	PUNCT
cusj-5580	596	11	this	this	DET
cusj-5580	596	12	entire	entire	ADJ
cusj-5580	596	13	synthesis	synthesis	NOUN
cusj-5580	596	14	would	would	AUX
cusj-5580	596	15	take	take	VERB
cusj-5580	596	16	over	over	ADP
cusj-5580	596	17	100	100	NUM
cusj-5580	596	18	hours	hour	NOUN
cusj-5580	596	19	in	in	ADP
cusj-5580	596	20	reaction	reaction	NOUN
cusj-5580	596	21	time	time	NOUN
cusj-5580	596	22	and	and	CCONJ
cusj-5580	596	23	an	an	DET
cusj-5580	596	24	estimated	estimate	VERB
cusj-5580	596	25	50	50	NUM
cusj-5580	596	26	hours	hour	NOUN
cusj-5580	596	27	in	in	ADP
cusj-5580	596	28	cleaning	cleaning	NOUN
cusj-5580	596	29	and	and	CCONJ
cusj-5580	596	30	separation	separation	NOUN
cusj-5580	596	31	downtime	downtime	NOUN
cusj-5580	596	32	.	.	PUNCT
cusj-5580	597	1	therefore	therefore	ADV
cusj-5580	597	2	,	,	PUNCT
cusj-5580	597	3	novartis	novartis	PROPN
cusj-5580	597	4	’s	’s	PART
cusj-5580	597	5	primary	primary	ADJ
cusj-5580	597	6	pathway	pathway	NOUN
cusj-5580	597	7	method	method	NOUN
cusj-5580	597	8	is	be	AUX
cusj-5580	597	9	an	an	DET
cusj-5580	597	10	expensive	expensive	ADJ
cusj-5580	597	11	and	and	CCONJ
cusj-5580	597	12	time	time	NOUN
cusj-5580	597	13	-	-	PUNCT
cusj-5580	597	14	consuming	consume	VERB
cusj-5580	597	15	process	process	NOUN
cusj-5580	597	16	with	with	ADP
cusj-5580	597	17	undisclosed	undisclosed	ADJ
cusj-5580	597	18	yields	yield	NOUN
cusj-5580	597	19	that	that	PRON
cusj-5580	597	20	are	be	AUX
cusj-5580	597	21	expected	expect	VERB
cusj-5580	597	22	to	to	PART
cusj-5580	597	23	require	require	VERB
cusj-5580	597	24	additional	additional	ADJ
cusj-5580	597	25	purification	purification	NOUN
cusj-5580	597	26	steps	step	NOUN
cusj-5580	597	27	.	.	PUNCT
cusj-5580	598	1	review	review	NOUN
cusj-5580	598	2	of	of	ADP
cusj-5580	598	3	the	the	DET
cusj-5580	598	4	alternative	alternative	ADJ
cusj-5580	598	5	nilotinib	nilotinib	NOUN
cusj-5580	598	6	synthesis	synthesis	NOUN
cusj-5580	598	7	pathways	pathway	NOUN
cusj-5580	598	8	although	although	SCONJ
cusj-5580	598	9	the	the	DET
cusj-5580	598	10	novartis	novartis	NOUN
cusj-5580	598	11	synthesis	synthesis	NOUN
cusj-5580	598	12	for	for	ADP
cusj-5580	598	13	nilotinib	nilotinib	NOUN
cusj-5580	598	14	is	be	AUX
cusj-5580	598	15	functional	functional	ADJ
cusj-5580	598	16	,	,	PUNCT
cusj-5580	598	17	there	there	PRON
cusj-5580	598	18	has	have	AUX
cusj-5580	598	19	been	be	AUX
cusj-5580	598	20	much	much	ADJ
cusj-5580	598	21	effort	effort	NOUN
cusj-5580	598	22	in	in	ADP
cusj-5580	598	23	developing	develop	VERB
cusj-5580	598	24	alternative	alternative	ADJ
cusj-5580	598	25	syntheses	synthesis	NOUN
cusj-5580	598	26	which	which	PRON
cusj-5580	598	27	mitigate	mitigate	VERB
cusj-5580	598	28	the	the	DET
cusj-5580	598	29	drawbacks	drawback	NOUN
cusj-5580	598	30	present	present	ADJ
cusj-5580	598	31	in	in	ADP
cusj-5580	598	32	the	the	DET
cusj-5580	598	33	novartis	novartis	NOUN
cusj-5580	598	34	synthesis	synthesis	NOUN
cusj-5580	598	35	pathway	pathway	NOUN
cusj-5580	598	36	.	.	PUNCT
cusj-5580	599	1	the	the	DET
cusj-5580	599	2	five	five	NUM
cusj-5580	599	3	known	know	VERB
cusj-5580	599	4	paths	path	NOUN
cusj-5580	599	5	for	for	ADP
cusj-5580	599	6	nilotinib	nilotinib	NOUN
cusj-5580	599	7	synthesis	synthesis	NOUN
cusj-5580	599	8	were	be	AUX
cusj-5580	599	9	compiled	compile	VERB
cusj-5580	599	10	and	and	CCONJ
cusj-5580	599	11	are	be	AUX
cusj-5580	599	12	outlined	outline	VERB
cusj-5580	599	13	in	in	ADP
cusj-5580	599	14	table	table	NOUN
cusj-5580	599	15	1	1	NUM
cusj-5580	599	16	.	.	PUNCT
cusj-5580	600	1	in	in	ADP
cusj-5580	600	2	addition	addition	NOUN
cusj-5580	600	3	to	to	ADP
cusj-5580	600	4	the	the	DET
cusj-5580	600	5	aforementioned	aforementione	VERB
cusj-5580	600	6	weaknesses	weakness	NOUN
cusj-5580	600	7	to	to	ADP
cusj-5580	600	8	the	the	DET
cusj-5580	600	9	novartis	novartis	NOUN
cusj-5580	600	10	synthesis	synthesis	NOUN
cusj-5580	600	11	,	,	PUNCT
cusj-5580	600	12	the	the	DET
cusj-5580	600	13	other	other	ADJ
cusj-5580	600	14	syntheses	synthesis	NOUN
cusj-5580	600	15	(	(	PUNCT
cusj-5580	600	16	table	table	NOUN
cusj-5580	600	17	1	1	NUM
cusj-5580	600	18	)	)	PUNCT
cusj-5580	600	19	also	also	ADV
cusj-5580	600	20	feature	feature	VERB
cusj-5580	600	21	several	several	ADJ
cusj-5580	600	22	key	key	ADJ
cusj-5580	600	23	weaknesses	weakness	NOUN
cusj-5580	600	24	affecting	affect	VERB
cusj-5580	600	25	their	their	PRON
cusj-5580	600	26	practicality	practicality	NOUN
cusj-5580	600	27	and	and	CCONJ
cusj-5580	600	28	profitability	profitability	NOUN
cusj-5580	600	29	.	.	PUNCT
cusj-5580	601	1	the	the	DET
cusj-5580	601	2	buchwald	buchwald	ADJ
cusj-5580	601	3	synthesis	synthesis	NOUN
cusj-5580	601	4	requires	require	VERB
cusj-5580	601	5	many	many	ADJ
cusj-5580	601	6	solid	solid	ADJ
cusj-5580	601	7	catalysts	catalyst	NOUN
cusj-5580	601	8	.	.	PUNCT
cusj-5580	602	1	however	however	ADV
cusj-5580	602	2	,	,	PUNCT
cusj-5580	602	3	this	this	PRON
cusj-5580	602	4	is	be	AUX
cusj-5580	602	5	balanced	balance	VERB
cusj-5580	602	6	by	by	ADP
cusj-5580	602	7	the	the	DET
cusj-5580	602	8	minimal	minimal	ADJ
cusj-5580	602	9	number	number	NOUN
cusj-5580	602	10	of	of	ADP
cusj-5580	602	11	steps	step	NOUN
cusj-5580	602	12	and	and	CCONJ
cusj-5580	602	13	the	the	DET
cusj-5580	602	14	significantly	significantly	ADV
cusj-5580	602	15	shorter	short	ADJ
cusj-5580	602	16	reaction	reaction	NOUN
cusj-5580	602	17	time	time	NOUN
cusj-5580	602	18	required	require	VERB
cusj-5580	602	19	(	(	PUNCT
cusj-5580	602	20	24h	24h	NOUN
cusj-5580	602	21	)	)	PUNCT
cusj-5580	602	22	in	in	ADP
cusj-5580	602	23	comparison	comparison	NOUN
cusj-5580	602	24	to	to	ADP
cusj-5580	602	25	the	the	DET
cusj-5580	602	26	novartis	novartis	NOUN
cusj-5580	602	27	method	method	NOUN
cusj-5580	602	28	figure	figure	NOUN
cusj-5580	602	29	2	2	NUM
cusj-5580	602	30	.	.	PUNCT
cusj-5580	602	31	process	process	NOUN
cusj-5580	602	32	flow	flow	NOUN
cusj-5580	602	33	diagram	diagram	NOUN
cusj-5580	602	34	of	of	ADP
cusj-5580	602	35	novartis	novartis	PROPN
cusj-5580	602	36	’s	’s	PART
cusj-5580	602	37	synthesis	synthesis	NOUN
cusj-5580	602	38	pathway	pathway	NOUN
cusj-5580	602	39	of	of	ADP
cusj-5580	602	40	nilotinib	nilotinib	NOUN
cusj-5580	602	41	.	.	PUNCT
cusj-5580	603	1	cusj	cusj	VERB
cusj-5580	603	2	2019	2019	NUM
cusj-5580	603	3	_	_	PUNCT
cusj-5580	604	1	_	_	PUNCT
cusj-5580	605	1	_	_	PUNCT
cusj-5580	606	1	_	_	PUNCT
cusj-5580	607	1	_	_	PUNCT
cusj-5580	608	1	_	_	PUNCT
cusj-5580	609	1	_	_	PUNCT
cusj-5580	610	1	_	_	PUNCT
cusj-5580	611	1	_	_	PUNCT
cusj-5580	612	1	_	_	PUNCT
cusj-5580	613	1	_	_	PUNCT
cusj-5580	614	1	_	_	PUNCT
cusj-5580	615	1	_	_	PUNCT
cusj-5580	616	1	_	_	PUNCT
cusj-5580	617	1	_	_	PUNCT
cusj-5580	618	1	_	_	PUNCT
cusj-5580	619	1	_	_	PUNCT
cusj-5580	620	1	_	_	PUNCT
cusj-5580	621	1	_	_	PUNCT
cusj-5580	622	1	_	_	PUNCT
cusj-5580	623	1	_	_	PUNCT
cusj-5580	624	1	_	_	PUNCT
cusj-5580	625	1	_	_	PUNCT
cusj-5580	626	1	_	_	PUNCT
cusj-5580	627	1	_	_	PUNCT
cusj-5580	628	1	_	_	PUNCT
cusj-5580	629	1	_	_	PUNCT
cusj-5580	630	1	_	_	PUNCT
cusj-5580	631	1	_	_	PUNCT
cusj-5580	632	1	_	_	PUNCT
cusj-5580	633	1	_	_	PUNCT
cusj-5580	634	1	_	_	PUNCT
cusj-5580	635	1	_	_	PUNCT
cusj-5580	636	1	_	_	PUNCT
cusj-5580	637	1	_	_	PUNCT
cusj-5580	638	1	_	_	PUNCT
cusj-5580	639	1	_	_	PUNCT
cusj-5580	640	1	_	_	PUNCT
cusj-5580	641	1	_	_	PUNCT
cusj-5580	642	1	_	_	PUNCT
cusj-5580	643	1	_	_	PUNCT
cusj-5580	644	1	_	_	PUNCT
cusj-5580	645	1	_	_	PUNCT
cusj-5580	646	1	_	_	PUNCT
cusj-5580	647	1	_	_	PUNCT
cusj-5580	648	1	_	_	PUNCT
cusj-5580	649	1	_	_	PUNCT
cusj-5580	650	1	_	_	PUNCT
cusj-5580	651	1	_	_	PUNCT
cusj-5580	652	1	_	_	PUNCT
cusj-5580	653	1	_	_	PUNCT
cusj-5580	654	1	_	_	PUNCT
cusj-5580	655	1	_	_	PUNCT
cusj-5580	656	1	_	_	PUNCT
cusj-5580	657	1	_	_	PUNCT
cusj-5580	658	1	_	_	PUNCT
cusj-5580	659	1	_	_	PUNCT
cusj-5580	660	1	_	_	PUNCT
cusj-5580	661	1	_	_	PUNCT
cusj-5580	662	1	_	_	PUNCT
cusj-5580	663	1	_	_	PUNCT
cusj-5580	664	1	_	_	PUNCT
cusj-5580	665	1	_	_	PUNCT
cusj-5580	666	1	_	_	PUNCT
cusj-5580	667	1	_	_	PUNCT
cusj-5580	668	1	_	_	PUNCT
cusj-5580	669	1	_	_	PUNCT
cusj-5580	670	1	_	_	PUNCT
cusj-5580	671	1	_	_	PUNCT
cusj-5580	672	1	_	_	PUNCT
cusj-5580	673	1	_	_	PUNCT
cusj-5580	674	1	_	_	PUNCT
cusj-5580	675	1	_	_	PUNCT
cusj-5580	676	1	_	_	PUNCT
cusj-5580	677	1	_	_	PUNCT
cusj-5580	678	1	_	_	PUNCT
cusj-5580	679	1	_	_	PUNCT
cusj-5580	680	1	_	_	PUNCT
cusj-5580	681	1	_	_	PUNCT
cusj-5580	682	1	_	_	PUNCT
cusj-5580	683	1	_	_	PUNCT
cusj-5580	684	1	_	_	PUNCT
cusj-5580	685	1	_	_	PUNCT
cusj-5580	686	1	_	_	PUNCT
cusj-5580	687	1	_	_	PUNCT
cusj-5580	688	1	_	_	PUNCT
cusj-5580	689	1	_	_	PUNCT
cusj-5580	690	1	_	_	PUNCT
cusj-5580	691	1	_	_	PUNCT
cusj-5580	692	1	_	_	PUNCT
cusj-5580	693	1	_	_	PUNCT
cusj-5580	694	1	_	_	PUNCT
cusj-5580	695	1	_	_	PUNCT
cusj-5580	696	1	_	_	PUNCT
cusj-5580	697	1	_	_	PUNCT
cusj-5580	698	1	_	_	PUNCT
cusj-5580	699	1	_	_	PUNCT
cusj-5580	700	1	_	_	PUNCT
cusj-5580	701	1	_	_	PUNCT
cusj-5580	702	1	_	_	PUNCT
cusj-5580	703	1	_	_	PUNCT
cusj-5580	704	1	_	_	PUNCT
cusj-5580	705	1	_	_	PUNCT
cusj-5580	706	1	_	_	PUNCT
cusj-5580	707	1	_	_	PUNCT
cusj-5580	708	1	_	_	PUNCT
cusj-5580	709	1	_	_	PUNCT
cusj-5580	710	1	_	_	PUNCT
cusj-5580	711	1	_	_	PUNCT
cusj-5580	712	1	_	_	PUNCT
cusj-5580	713	1	_	_	PUNCT
cusj-5580	714	1	_	_	PUNCT
cusj-5580	715	1	_	_	PUNCT
cusj-5580	716	1	_	_	PUNCT
cusj-5580	717	1	_	_	PUNCT
cusj-5580	718	1	_	_	PUNCT
cusj-5580	719	1	_	_	PUNCT
cusj-5580	720	1	_	_	PUNCT
cusj-5580	721	1	_	_	PUNCT
cusj-5580	722	1	_	_	PUNCT
cusj-5580	723	1	_	_	PUNCT
cusj-5580	724	1	_	_	PUNCT
cusj-5580	725	1	_	_	PUNCT
cusj-5580	726	1	_	_	PUNCT
cusj-5580	727	1	_	_	PUNCT
cusj-5580	728	1	_	_	PUNCT
cusj-5580	729	1	_	_	PUNCT
cusj-5580	730	1	_	_	PUNCT
cusj-5580	731	1	_	_	PUNCT
cusj-5580	732	1	_	_	PUNCT
cusj-5580	733	1	_	_	PUNCT
cusj-5580	734	1	_	_	PUNCT
cusj-5580	735	1	_	_	PUNCT
cusj-5580	736	1	_	_	PUNCT
cusj-5580	737	1	_	_	PUNCT
cusj-5580	738	1	_	_	PUNCT
cusj-5580	739	1	_	_	PUNCT
cusj-5580	740	1	_	_	PUNCT
cusj-5580	741	1	_	_	PUNCT
cusj-5580	742	1	_	_	PUNCT
cusj-5580	743	1	_	_	PUNCT
cusj-5580	744	1	_	_	PUNCT
cusj-5580	745	1	_	_	PUNCT
cusj-5580	746	1	_	_	PUNCT
cusj-5580	747	1	_	_	PUNCT
cusj-5580	748	1	_	_	PUNCT
cusj-5580	749	1	_	_	PUNCT
cusj-5580	750	1	_	_	PUNCT
cusj-5580	751	1	_	_	PUNCT
cusj-5580	752	1	_	_	PUNCT
cusj-5580	753	1	_	_	PUNCT
cusj-5580	754	1	_	_	PUNCT
cusj-5580	755	1	_	_	PUNCT
cusj-5580	756	1	_	_	PUNCT
cusj-5580	757	1	_	_	PUNCT
cusj-5580	758	1	_	_	PUNCT
cusj-5580	759	1	_	_	PUNCT
cusj-5580	760	1	_	_	PUNCT
cusj-5580	761	1	_	_	PUNCT
cusj-5580	762	1	_	_	PUNCT
cusj-5580	763	1	_	_	PUNCT
cusj-5580	764	1	_	_	PUNCT
cusj-5580	765	1	_	_	PUNCT
cusj-5580	766	1	_	_	PUNCT
cusj-5580	767	1	_	_	PUNCT
cusj-5580	768	1	_	_	PUNCT
cusj-5580	769	1	_	_	PUNCT
cusj-5580	770	1	_	_	PUNCT
cusj-5580	771	1	_	_	PUNCT
cusj-5580	772	1	_	_	PUNCT
cusj-5580	773	1	24	24	NUM
cusj-5580	773	2	(	(	PUNCT
cusj-5580	773	3	>	>	X
cusj-5580	773	4	100h	100h	NUM
cusj-5580	773	5	)	)	PUNCT
cusj-5580	773	6	(	(	PUNCT
cusj-5580	773	7	ueda	ueda	PROPN
cusj-5580	773	8	et	et	PROPN
cusj-5580	773	9	al	al	PROPN
cusj-5580	773	10	.	.	PROPN
cusj-5580	773	11	,	,	PUNCT
cusj-5580	773	12	2012	2012	NUM
cusj-5580	773	13	)	)	PUNCT
cusj-5580	773	14	.	.	PUNCT
cusj-5580	774	1	the	the	DET
cusj-5580	774	2	chen	chen	PROPN
cusj-5580	774	3	synthesis	synthesis	NOUN
cusj-5580	774	4	has	have	AUX
cusj-5580	774	5	been	be	AUX
cusj-5580	774	6	found	find	VERB
cusj-5580	774	7	to	to	PART
cusj-5580	774	8	have	have	VERB
cusj-5580	774	9	long	long	ADJ
cusj-5580	774	10	reaction	reaction	NOUN
cusj-5580	774	11	times	time	NOUN
cusj-5580	774	12	with	with	ADP
cusj-5580	774	13	certain	certain	ADJ
cusj-5580	774	14	steps	step	NOUN
cusj-5580	774	15	taking	take	VERB
cusj-5580	774	16	68	68	NUM
cusj-5580	774	17	hours	hour	NOUN
cusj-5580	774	18	to	to	PART
cusj-5580	774	19	complete	complete	VERB
cusj-5580	774	20	,	,	PUNCT
cusj-5580	774	21	while	while	SCONJ
cusj-5580	774	22	the	the	DET
cusj-5580	774	23	total	total	ADJ
cusj-5580	774	24	reaction	reaction	NOUN
cusj-5580	774	25	time	time	NOUN
cusj-5580	774	26	for	for	ADP
cusj-5580	774	27	the	the	DET
cusj-5580	774	28	process	process	NOUN
cusj-5580	774	29	was	be	AUX
cusj-5580	774	30	over	over	ADV
cusj-5580	774	31	three	three	NUM
cusj-5580	774	32	days	day	NOUN
cusj-5580	774	33	.	.	PUNCT
cusj-5580	775	1	furthermore	furthermore	ADV
cusj-5580	775	2	,	,	PUNCT
cusj-5580	775	3	the	the	DET
cusj-5580	775	4	chen	chen	PROPN
cusj-5580	775	5	synthesis	synthesis	NOUN
cusj-5580	775	6	features	feature	VERB
cusj-5580	775	7	a	a	DET
cusj-5580	775	8	very	very	ADV
cusj-5580	775	9	low	low	ADJ
cusj-5580	775	10	overall	overall	ADJ
cusj-5580	775	11	yield	yield	NOUN
cusj-5580	775	12	,	,	PUNCT
cusj-5580	775	13	around	around	ADV
cusj-5580	775	14	40	40	NUM
cusj-5580	775	15	%	%	NOUN
cusj-5580	775	16	.	.	PUNCT
cusj-5580	776	1	additionally	additionally	ADV
cusj-5580	776	2	,	,	PUNCT
cusj-5580	776	3	the	the	DET
cusj-5580	776	4	copper	copper	NOUN
cusj-5580	776	5	catalyst	catalyst	NOUN
cusj-5580	776	6	used	use	VERB
cusj-5580	776	7	in	in	ADP
cusj-5580	776	8	step	step	NOUN
cusj-5580	776	9	1a	1a	NOUN
cusj-5580	776	10	of	of	ADP
cusj-5580	776	11	the	the	DET
cusj-5580	776	12	chen	chen	PROPN
cusj-5580	776	13	synthesis	synthesis	NOUN
cusj-5580	776	14	is	be	AUX
cusj-5580	776	15	particularly	particularly	ADV
cusj-5580	776	16	slow	slow	ADJ
cusj-5580	776	17	and	and	CCONJ
cusj-5580	776	18	non	non	ADJ
cusj-5580	776	19	-	-	ADJ
cusj-5580	776	20	regioselective	regioselective	ADJ
cusj-5580	776	21	,	,	PUNCT
cusj-5580	776	22	resulting	result	VERB
cusj-5580	776	23	in	in	ADP
cusj-5580	776	24	the	the	DET
cusj-5580	776	25	need	need	NOUN
cusj-5580	776	26	for	for	ADP
cusj-5580	776	27	additional	additional	ADJ
cusj-5580	776	28	separation	separation	NOUN
cusj-5580	776	29	in	in	ADP
cusj-5580	776	30	order	order	NOUN
cusj-5580	776	31	to	to	PART
cusj-5580	776	32	isolate	isolate	VERB
cusj-5580	776	33	the	the	DET
cusj-5580	776	34	key	key	ADJ
cusj-5580	776	35	aniline	aniline	ADJ
cusj-5580	776	36	intermediate	intermediate	ADJ
cusj-5580	776	37	,	,	PUNCT
cusj-5580	776	38	further	far	ADV
cusj-5580	776	39	complicating	complicate	VERB
cusj-5580	776	40	an	an	DET
cusj-5580	776	41	already	already	ADV
cusj-5580	776	42	unwieldy	unwieldy	ADJ
cusj-5580	776	43	process	process	NOUN
cusj-5580	776	44	(	(	PUNCT
cusj-5580	776	45	chen	chen	PROPN
cusj-5580	776	46	et	et	PROPN
cusj-5580	776	47	al	al	PROPN
cusj-5580	776	48	.	.	PROPN
cusj-5580	776	49	,	,	PUNCT
cusj-5580	776	50	2009	2009	NUM
cusj-5580	776	51	)	)	PUNCT
cusj-5580	776	52	.	.	PUNCT
cusj-5580	777	1	the	the	DET
cusj-5580	777	2	teva	teva	ADJ
cusj-5580	777	3	synthesis	synthesis	NOUN
cusj-5580	777	4	likewise	likewise	ADV
cusj-5580	777	5	was	be	AUX
cusj-5580	777	6	found	find	VERB
cusj-5580	777	7	to	to	PART
cusj-5580	777	8	be	be	AUX
cusj-5580	777	9	exceptionally	exceptionally	ADV
cusj-5580	777	10	long	long	ADJ
cusj-5580	777	11	,	,	PUNCT
cusj-5580	777	12	taking	take	VERB
cusj-5580	777	13	over	over	ADP
cusj-5580	777	14	five	five	NUM
cusj-5580	777	15	days	day	NOUN
cusj-5580	777	16	total	total	ADJ
cusj-5580	777	17	.	.	PUNCT
cusj-5580	778	1	additionally	additionally	ADV
cusj-5580	778	2	,	,	PUNCT
cusj-5580	778	3	the	the	DET
cusj-5580	778	4	many	many	ADJ
cusj-5580	778	5	solvents	solvent	NOUN
cusj-5580	778	6	used	use	VERB
cusj-5580	778	7	can	can	AUX
cusj-5580	778	8	complicate	complicate	VERB
cusj-5580	778	9	the	the	DET
cusj-5580	778	10	unit	unit	NOUN
cusj-5580	778	11	operations	operation	NOUN
cusj-5580	778	12	involved	involve	VERB
cusj-5580	778	13	due	due	ADP
cusj-5580	778	14	to	to	ADP
cusj-5580	778	15	the	the	DET
cusj-5580	778	16	extensive	extensive	ADJ
cusj-5580	778	17	solvent	solvent	NOUN
cusj-5580	778	18	switching	switch	VERB
cusj-5580	778	19	they	they	PRON
cusj-5580	778	20	necessitate	necessitate	ADJ
cusj-5580	778	21	(	(	PUNCT
cusj-5580	778	22	yeori	yeori	NOUN
cusj-5580	778	23	et	et	PROPN
cusj-5580	778	24	al	al	PROPN
cusj-5580	778	25	.	.	PROPN
cusj-5580	778	26	,	,	PUNCT
cusj-5580	778	27	2010	2010	NUM
cusj-5580	778	28	)	)	PUNCT
cusj-5580	778	29	.	.	PUNCT
cusj-5580	779	1	lastly	lastly	ADV
cusj-5580	779	2	,	,	PUNCT
cusj-5580	779	3	the	the	DET
cusj-5580	779	4	ariad	ariad	NOUN
cusj-5580	779	5	synthesis	synthesis	NOUN
cusj-5580	779	6	,	,	PUNCT
cusj-5580	779	7	although	although	SCONJ
cusj-5580	779	8	brief	brief	ADJ
cusj-5580	779	9	at	at	ADP
cusj-5580	779	10	only	only	ADV
cusj-5580	779	11	four	four	NUM
cusj-5580	779	12	steps	step	NOUN
cusj-5580	779	13	,	,	PUNCT
cusj-5580	779	14	was	be	AUX
cusj-5580	779	15	reported	report	VERB
cusj-5580	779	16	to	to	PART
cusj-5580	779	17	have	have	AUX
cusj-5580	779	18	be	be	AUX
cusj-5580	779	19	unscalable	unscalable	ADJ
cusj-5580	779	20	,	,	PUNCT
cusj-5580	779	21	as	as	SCONJ
cusj-5580	779	22	its	its	PRON
cusj-5580	779	23	final	final	ADJ
cusj-5580	779	24	step	step	NOUN
cusj-5580	779	25	has	have	AUX
cusj-5580	779	26	been	be	AUX
cusj-5580	779	27	found	find	VERB
cusj-5580	779	28	to	to	PART
cusj-5580	779	29	give	give	VERB
cusj-5580	779	30	inconsistent	inconsistent	ADJ
cusj-5580	779	31	yields	yield	NOUN
cusj-5580	779	32	at	at	ADP
cusj-5580	779	33	scales	scale	NOUN
cusj-5580	779	34	above	above	ADP
cusj-5580	779	35	250	250	NUM
cusj-5580	779	36	milligrams	milligram	NOUN
cusj-5580	779	37	,	,	PUNCT
cusj-5580	779	38	resulting	result	VERB
cusj-5580	779	39	in	in	ADP
cusj-5580	779	40	impracticality	impracticality	NOUN
cusj-5580	779	41	at	at	ADP
cusj-5580	779	42	an	an	DET
cusj-5580	779	43	industrial	industrial	ADJ
cusj-5580	779	44	scale	scale	NOUN
cusj-5580	779	45	(	(	PUNCT
cusj-5580	779	46	deadman	deadman	PROPN
cusj-5580	779	47	et	et	PROPN
cusj-5580	779	48	al	al	PROPN
cusj-5580	779	49	.	.	PROPN
cusj-5580	779	50	,	,	PUNCT
cusj-5580	779	51	2013	2013	NUM
cusj-5580	779	52	)	)	PUNCT
cusj-5580	779	53	.	.	PUNCT
cusj-5580	780	1	table	table	NOUN
cusj-5580	780	2	1	1	NUM
cusj-5580	780	3	.	.	PUNCT
cusj-5580	781	1	a	a	DET
cusj-5580	781	2	comparison	comparison	NOUN
cusj-5580	781	3	of	of	ADP
cusj-5580	781	4	the	the	DET
cusj-5580	781	5	five	five	NUM
cusj-5580	781	6	existing	exist	VERB
cusj-5580	781	7	nilotinib	nilotinib	NOUN
cusj-5580	781	8	syntheses	synthesis	NOUN
cusj-5580	781	9	according	accord	VERB
cusj-5580	781	10	to	to	ADP
cusj-5580	781	11	their	their	PRON
cusj-5580	781	12	number	number	NOUN
cusj-5580	781	13	of	of	ADP
cusj-5580	781	14	steps	step	NOUN
cusj-5580	781	15	.	.	PUNCT
cusj-5580	782	1	the	the	DET
cusj-5580	782	2	associated	associated	ADJ
cusj-5580	782	3	reaction	reaction	NOUN
cusj-5580	782	4	temperatures	temperature	NOUN
cusj-5580	782	5	,	,	PUNCT
cusj-5580	782	6	reaction	reaction	NOUN
cusj-5580	782	7	pressures	pressure	NOUN
cusj-5580	782	8	,	,	PUNCT
cusj-5580	782	9	step	step	NOUN
cusj-5580	782	10	yields	yield	NOUN
cusj-5580	782	11	,	,	PUNCT
cusj-5580	782	12	solvents	solvent	NOUN
cusj-5580	782	13	,	,	PUNCT
cusj-5580	782	14	catalysts	catalyst	NOUN
cusj-5580	782	15	,	,	PUNCT
cusj-5580	782	16	and	and	CCONJ
cusj-5580	782	17	reaction	reaction	NOUN
cusj-5580	782	18	times	time	NOUN
cusj-5580	782	19	are	be	AUX
cusj-5580	782	20	also	also	ADV
cusj-5580	782	21	noted	note	VERB
cusj-5580	782	22	with	with	ADP
cusj-5580	782	23	respect	respect	NOUN
cusj-5580	782	24	to	to	ADP
cusj-5580	782	25	each	each	DET
cusj-5580	782	26	reaction	reaction	NOUN
cusj-5580	782	27	stage	stage	NOUN
cusj-5580	782	28	.	.	PUNCT
cusj-5580	783	1	of	of	ADP
cusj-5580	783	2	the	the	DET
cusj-5580	783	3	syntheses	synthesis	NOUN
cusj-5580	783	4	of	of	ADP
cusj-5580	783	5	nilotinib	nilotinib	NOUN
cusj-5580	783	6	that	that	PRON
cusj-5580	783	7	were	be	AUX
cusj-5580	783	8	discussed	discuss	VERB
cusj-5580	783	9	in	in	ADP
cusj-5580	783	10	table	table	NOUN
cusj-5580	783	11	1	1	NUM
cusj-5580	783	12	,	,	PUNCT
cusj-5580	783	13	the	the	DET
cusj-5580	783	14	buchwald	buchwald	ADJ
cusj-5580	783	15	synthesis	synthesis	NOUN
cusj-5580	783	16	seemed	seem	VERB
cusj-5580	783	17	by	by	ADP
cusj-5580	783	18	far	far	ADV
cusj-5580	783	19	the	the	DET
cusj-5580	783	20	most	most	ADV
cusj-5580	783	21	promising	promising	ADJ
cusj-5580	783	22	in	in	ADP
cusj-5580	783	23	terms	term	NOUN
cusj-5580	783	24	of	of	ADP
cusj-5580	783	25	developing	develop	VERB
cusj-5580	783	26	a	a	DET
cusj-5580	783	27	scalable	scalable	ADJ
cusj-5580	783	28	,	,	PUNCT
cusj-5580	783	29	flow	flow	NOUN
cusj-5580	783	30	-	-	PUNCT
cusj-5580	783	31	based	base	VERB
cusj-5580	783	32	synthesis	synthesis	NOUN
cusj-5580	783	33	process	process	NOUN
cusj-5580	783	34	of	of	ADP
cusj-5580	783	35	nilotinib	nilotinib	NOUN
cusj-5580	783	36	for	for	ADP
cusj-5580	783	37	the	the	DET
cusj-5580	783	38	production	production	NOUN
cusj-5580	783	39	of	of	ADP
cusj-5580	783	40	a	a	DET
cusj-5580	783	41	generic	generic	ADJ
cusj-5580	783	42	brand	brand	NOUN
cusj-5580	783	43	.	.	PUNCT
cusj-5580	784	1	figure	figure	VERB
cusj-5580	784	2	3	3	NUM
cusj-5580	784	3	.	.	PUNCT
cusj-5580	785	1	reaction	reaction	NOUN
cusj-5580	785	2	scheme	scheme	NOUN
cusj-5580	785	3	for	for	ADP
cusj-5580	785	4	the	the	DET
cusj-5580	785	5	buchwald	buchwald	ADJ
cusj-5580	785	6	synthesis	synthesis	NOUN
cusj-5580	785	7	of	of	ADP
cusj-5580	785	8	nilotinib	nilotinib	NOUN
cusj-5580	785	9	,	,	PUNCT
cusj-5580	785	10	modified	modify	VERB
cusj-5580	785	11	from	from	ADP
cusj-5580	785	12	ueda	ueda	PROPN
cusj-5580	785	13	et	et	PROPN
cusj-5580	785	14	al	al	PROPN
cusj-5580	785	15	.	.	PROPN
cusj-5580	785	16	,	,	PUNCT
cusj-5580	785	17	2012	2012	NUM
cusj-5580	785	18	.	.	PUNCT
cusj-5580	786	1	the	the	DET
cusj-5580	786	2	advantages	advantage	NOUN
cusj-5580	786	3	of	of	ADP
cusj-5580	786	4	the	the	DET
cusj-5580	786	5	buchwald	buchwald	ADJ
cusj-5580	786	6	synthesis	synthesis	NOUN
cusj-5580	786	7	that	that	PRON
cusj-5580	786	8	make	make	VERB
cusj-5580	786	9	it	it	PRON
cusj-5580	786	10	the	the	DET
cusj-5580	786	11	most	most	ADV
cusj-5580	786	12	promising	promising	ADJ
cusj-5580	786	13	are	be	AUX
cusj-5580	786	14	its	its	PRON
cusj-5580	786	15	three	three	NUM
cusj-5580	786	16	steps	step	NOUN
cusj-5580	786	17	taking	take	VERB
cusj-5580	786	18	approximately	approximately	ADV
cusj-5580	786	19	24	24	NUM
cusj-5580	786	20	hours	hour	NOUN
cusj-5580	786	21	of	of	ADP
cusj-5580	786	22	reaction	reaction	NOUN
cusj-5580	786	23	time	time	NOUN
cusj-5580	786	24	,	,	PUNCT
cusj-5580	786	25	fast	fast	ADJ
cusj-5580	786	26	and	and	CCONJ
cusj-5580	786	27	efficient	efficient	ADJ
cusj-5580	786	28	compared	compare	VERB
cusj-5580	786	29	to	to	ADP
cusj-5580	786	30	the	the	DET
cusj-5580	786	31	other	other	ADJ
cusj-5580	786	32	existing	exist	VERB
cusj-5580	786	33	methods	method	NOUN
cusj-5580	786	34	of	of	ADP
cusj-5580	786	35	nilotinib	nilotinib	NOUN
cusj-5580	786	36	synthesis	synthesis	NOUN
cusj-5580	786	37	.	.	PUNCT
cusj-5580	787	1	more	more	ADV
cusj-5580	787	2	importantly	importantly	ADV
cusj-5580	787	3	,	,	PUNCT
cusj-5580	787	4	the	the	DET
cusj-5580	787	5	buchwald	buchwald	ADJ
cusj-5580	787	6	synthesis	synthesis	NOUN
cusj-5580	787	7	is	be	AUX
cusj-5580	787	8	highly	highly	ADV
cusj-5580	787	9	regioselective	regioselective	ADJ
cusj-5580	787	10	in	in	ADP
cusj-5580	787	11	the	the	DET
cusj-5580	787	12	step	step	NOUN
cusj-5580	787	13	where	where	SCONJ
cusj-5580	787	14	an	an	DET
cusj-5580	787	15	important	important	ADJ
cusj-5580	787	16	aniline	aniline	NOUN
cusj-5580	787	17	compound	compound	NOUN
cusj-5580	787	18	is	be	AUX
cusj-5580	787	19	produced	produce	VERB
cusj-5580	787	20	(	(	PUNCT
cusj-5580	787	21	highlighted	highlight	VERB
cusj-5580	787	22	in	in	ADP
cusj-5580	787	23	the	the	DET
cusj-5580	787	24	red	red	PROPN
cusj-5580	787	25	box	box	PROPN
cusj-5580	787	26	in	in	ADP
cusj-5580	787	27	fig	fig	NOUN
cusj-5580	787	28	.	.	PUNCT
cusj-5580	788	1	3	3	NUM
cusj-5580	788	2	)	)	PUNCT
cusj-5580	788	3	.	.	PUNCT
cusj-5580	789	1	this	this	PRON
cusj-5580	789	2	gives	give	VERB
cusj-5580	789	3	the	the	DET
cusj-5580	789	4	buchwald	buchwald	ADJ
cusj-5580	789	5	synthesis	synthesis	NOUN
cusj-5580	789	6	a	a	DET
cusj-5580	789	7	distinct	distinct	ADJ
cusj-5580	789	8	advantage	advantage	NOUN
cusj-5580	789	9	over	over	ADP
cusj-5580	789	10	other	other	ADJ
cusj-5580	789	11	methods	method	NOUN
cusj-5580	789	12	of	of	ADP
cusj-5580	789	13	synthesizing	synthesize	VERB
cusj-5580	789	14	nilotinib	nilotinib	NOUN
cusj-5580	789	15	and	and	CCONJ
cusj-5580	789	16	more	more	ADV
cusj-5580	789	17	importantly	importantly	ADV
cusj-5580	789	18	,	,	PUNCT
cusj-5580	789	19	reduces	reduce	VERB
cusj-5580	789	20	the	the	DET
cusj-5580	789	21	need	need	NOUN
cusj-5580	789	22	for	for	ADP
cusj-5580	789	23	time	time	NOUN
cusj-5580	789	24	-	-	PUNCT
cusj-5580	789	25	intensive	intensive	ADJ
cusj-5580	789	26	regioselective	regioselective	ADJ
cusj-5580	789	27	purification	purification	NOUN
cusj-5580	789	28	at	at	ADP
cusj-5580	789	29	this	this	DET
cusj-5580	789	30	initial	initial	ADJ
cusj-5580	789	31	step	step	NOUN
cusj-5580	789	32	.	.	PUNCT
cusj-5580	790	1	lastly	lastly	ADV
cusj-5580	790	2	,	,	PUNCT
cusj-5580	790	3	the	the	DET
cusj-5580	790	4	buchwald	buchwald	ADJ
cusj-5580	790	5	synthesis	synthesis	NOUN
cusj-5580	790	6	requires	require	VERB
cusj-5580	790	7	only	only	ADV
cusj-5580	790	8	four	four	NUM
cusj-5580	790	9	,	,	PUNCT
cusj-5580	790	10	readily	readily	ADV
cusj-5580	790	11	purchasable	purchasable	ADJ
cusj-5580	790	12	starting	start	VERB
cusj-5580	790	13	reactants	reactant	NOUN
cusj-5580	790	14	:	:	PUNCT
cusj-5580	790	15	(	(	PUNCT
cusj-5580	790	16	1	1	X
cusj-5580	790	17	)	)	PUNCT
cusj-5580	790	18	3	3	NUM
cusj-5580	790	19	-	-	PUNCT
cusj-5580	790	20	amino-5	amino-5	NUM
cusj-5580	790	21	-	-	PUNCT
cusj-5580	790	22	bromobenzotrifluoride	bromobenzotrifluoride	ADJ
cusj-5580	790	23	(	(	PUNCT
cusj-5580	790	24	2	2	NUM
cusj-5580	790	25	)	)	PUNCT
cusj-5580	790	26	4	4	NUM
cusj-5580	790	27	-	-	PUNCT
cusj-5580	790	28	methylimidazole	methylimidazole	NOUN
cusj-5580	790	29	(	(	PUNCT
cusj-5580	790	30	3	3	NUM
cusj-5580	790	31	)	)	SYM
cusj-5580	790	32	4	4	NUM
cusj-5580	790	33	-	-	PUNCT
cusj-5580	790	34	pyrimidin-3	pyrimidin-3	NUM
cusj-5580	790	35	-	-	PUNCT
cusj-5580	790	36	yl	yl	NOUN
cusj-5580	790	37	-	-	PUNCT
cusj-5580	790	38	pyrimidine-2	pyrimidine-2	NOUN
cusj-5580	790	39	-	-	PUNCT
cusj-5580	790	40	amine	amine	ADJ
cusj-5580	790	41	(	(	PUNCT
cusj-5580	790	42	4	4	NUM
cusj-5580	790	43	)	)	PUNCT
cusj-5580	790	44	methyl	methyl	NOUN
cusj-5580	790	45	3	3	NUM
cusj-5580	790	46	-	-	PUNCT
cusj-5580	790	47	bromo-4	bromo-4	NOUN
cusj-5580	790	48	-	-	NOUN
cusj-5580	790	49	methylbenzoate	methylbenzoate	NOUN
cusj-5580	790	50	thus	thus	ADV
cusj-5580	790	51	,	,	PUNCT
cusj-5580	790	52	we	we	PRON
cusj-5580	790	53	chose	choose	VERB
cusj-5580	790	54	the	the	DET
cusj-5580	790	55	buchwald	buchwald	ADJ
cusj-5580	790	56	synthesis	synthesis	NOUN
cusj-5580	790	57	to	to	PART
cusj-5580	790	58	be	be	AUX
cusj-5580	790	59	the	the	DET
cusj-5580	790	60	focus	focus	NOUN
cusj-5580	790	61	of	of	ADP
cusj-5580	790	62	our	our	PRON
cusj-5580	790	63	computational	computational	ADJ
cusj-5580	790	64	process	process	NOUN
cusj-5580	790	65	scaling	scale	VERB
cusj-5580	790	66	methodology	methodology	NOUN
cusj-5580	790	67	.	.	PUNCT
cusj-5580	791	1	process	process	NOUN
cusj-5580	791	2	design	design	NOUN
cusj-5580	791	3	for	for	ADP
cusj-5580	791	4	an	an	DET
cusj-5580	791	5	industrial	industrial	ADJ
cusj-5580	791	6	scale	scale	NOUN
cusj-5580	791	7	buchwald	buchwald	NOUN
cusj-5580	791	8	synthesis	synthesis	NOUN
cusj-5580	791	9	of	of	ADP
cusj-5580	791	10	nilotinib	nilotinib	NOUN
cusj-5580	791	11	our	our	PRON
cusj-5580	791	12	goal	goal	NOUN
cusj-5580	791	13	was	be	AUX
cusj-5580	791	14	to	to	PART
cusj-5580	791	15	develop	develop	VERB
cusj-5580	791	16	a	a	DET
cusj-5580	791	17	scalable	scalable	ADJ
cusj-5580	791	18	,	,	PUNCT
cusj-5580	791	19	flow	flow	NOUN
cusj-5580	791	20	-	-	PUNCT
cusj-5580	791	21	based	base	VERB
cusj-5580	791	22	synthesis	synthesis	NOUN
cusj-5580	791	23	of	of	ADP
cusj-5580	791	24	nilotinib	nilotinib	NOUN
cusj-5580	791	25	which	which	PRON
cusj-5580	791	26	has	have	VERB
cusj-5580	791	27	greater	great	ADJ
cusj-5580	791	28	time	time	NOUN
cusj-5580	791	29	efficiency	efficiency	NOUN
cusj-5580	791	30	,	,	PUNCT
cusj-5580	791	31	safety	safety	NOUN
cusj-5580	791	32	,	,	PUNCT
cusj-5580	791	33	and	and	CCONJ
cusj-5580	791	34	yield	yield	NOUN
cusj-5580	791	35	than	than	ADP
cusj-5580	791	36	the	the	DET
cusj-5580	791	37	existing	exist	VERB
cusj-5580	791	38	novartis	novartis	NOUN
cusj-5580	791	39	synthesis	synthesis	NOUN
cusj-5580	791	40	.	.	PUNCT
cusj-5580	792	1	we	we	PRON
cusj-5580	792	2	hoped	hope	VERB
cusj-5580	792	3	to	to	PART
cusj-5580	792	4	employ	employ	VERB
cusj-5580	792	5	a	a	DET
cusj-5580	792	6	flow	flow	NOUN
cusj-5580	792	7	-	-	PUNCT
cusj-5580	792	8	chemistry	chemistry	NOUN
cusj-5580	792	9	based	base	VERB
cusj-5580	792	10	synthesis	synthesis	NOUN
cusj-5580	792	11	of	of	ADP
cusj-5580	792	12	nilotinib	nilotinib	NOUN
cusj-5580	792	13	.	.	PUNCT
cusj-5580	793	1	in	in	ADP
cusj-5580	793	2	contrast	contrast	NOUN
cusj-5580	793	3	to	to	PART
cusj-5580	793	4	batch	batch	VERB
cusj-5580	793	5	production	production	NOUN
cusj-5580	793	6	methods	method	NOUN
cusj-5580	793	7	,	,	PUNCT
cusj-5580	793	8	a	a	DET
cusj-5580	793	9	flowbased	flowbase	VERB
cusj-5580	793	10	synthesis	synthesis	NOUN
cusj-5580	793	11	would	would	AUX
cusj-5580	793	12	involve	involve	VERB
cusj-5580	793	13	the	the	DET
cusj-5580	793	14	use	use	NOUN
cusj-5580	793	15	of	of	ADP
cusj-5580	793	16	a	a	DET
cusj-5580	793	17	single	single	ADJ
cusj-5580	793	18	,	,	PUNCT
cusj-5580	793	19	continuous	continuous	ADJ
cusj-5580	793	20	flowing	flow	VERB
cusj-5580	793	21	stream	stream	NOUN
cusj-5580	793	22	wherein	wherein	SCONJ
cusj-5580	793	23	the	the	DET
cusj-5580	793	24	reaction	reaction	NOUN
cusj-5580	793	25	would	would	AUX
cusj-5580	793	26	take	take	VERB
cusj-5580	793	27	place	place	NOUN
cusj-5580	793	28	in	in	ADP
cusj-5580	793	29	a	a	DET
cusj-5580	793	30	series	series	NOUN
cusj-5580	793	31	of	of	ADP
cusj-5580	793	32	controlled	control	VERB
cusj-5580	793	33	steps	step	NOUN
cusj-5580	793	34	without	without	ADP
cusj-5580	793	35	the	the	DET
cusj-5580	793	36	need	need	NOUN
cusj-5580	793	37	for	for	ADP
cusj-5580	793	38	multiple	multiple	ADJ
cusj-5580	793	39	batch	batch	NOUN
cusj-5580	793	40	reactors	reactor	NOUN
cusj-5580	793	41	.	.	PUNCT
cusj-5580	794	1	as	as	SCONJ
cusj-5580	794	2	reported	report	VERB
cusj-5580	794	3	in	in	ADP
cusj-5580	794	4	previous	previous	ADJ
cusj-5580	794	5	literature	literature	NOUN
cusj-5580	794	6	,	,	PUNCT
cusj-5580	794	7	multi	multi	ADJ
cusj-5580	794	8	-	-	ADJ
cusj-5580	794	9	step	step	ADJ
cusj-5580	794	10	batch	batch	NOUN
cusj-5580	794	11	processes	process	NOUN
cusj-5580	794	12	require	require	VERB
cusj-5580	794	13	process	process	NOUN
cusj-5580	794	14	control	control	NOUN
cusj-5580	794	15	and	and	CCONJ
cusj-5580	794	16	purification	purification	NOUN
cusj-5580	794	17	techniques	technique	NOUN
cusj-5580	794	18	which	which	PRON
cusj-5580	794	19	are	be	AUX
cusj-5580	794	20	highly	highly	ADV
cusj-5580	794	21	complex	complex	ADJ
cusj-5580	794	22	in	in	ADP
cusj-5580	794	23	comparison	comparison	NOUN
cusj-5580	794	24	to	to	ADP
cusj-5580	794	25	flow	flow	NOUN
cusj-5580	794	26	-	-	PUNCT
cusj-5580	794	27	based	base	VERB
cusj-5580	794	28	reactions	reaction	NOUN
cusj-5580	794	29	(	(	PUNCT
cusj-5580	794	30	hopkin	hopkin	X
cusj-5580	794	31	et	et	PROPN
cusj-5580	794	32	al	al	PROPN
cusj-5580	794	33	.	.	PROPN
cusj-5580	794	34	,	,	PUNCT
cusj-5580	794	35	2010	2010	NUM
cusj-5580	794	36	)	)	PUNCT
cusj-5580	794	37	.	.	PUNCT
cusj-5580	795	1	as	as	ADP
cusj-5580	795	2	such	such	ADJ
cusj-5580	795	3	,	,	PUNCT
cusj-5580	795	4	a	a	DET
cusj-5580	795	5	general	general	ADJ
cusj-5580	795	6	process	process	NOUN
cusj-5580	795	7	flow	flow	NOUN
cusj-5580	795	8	diagram	diagram	NOUN
cusj-5580	795	9	which	which	PRON
cusj-5580	795	10	illustrates	illustrate	VERB
cusj-5580	795	11	the	the	DET
cusj-5580	795	12	changes	change	NOUN
cusj-5580	795	13	and	and	CCONJ
cusj-5580	795	14	modifications	modification	NOUN
cusj-5580	795	15	we	we	PRON
cusj-5580	795	16	wish	wish	VERB
cusj-5580	795	17	to	to	PART
cusj-5580	795	18	make	make	VERB
cusj-5580	795	19	to	to	ADP
cusj-5580	795	20	the	the	DET
cusj-5580	795	21	existing	exist	VERB
cusj-5580	795	22	buchwald	buchwald	ADJ
cusj-5580	795	23	synthesis	synthesis	NOUN
cusj-5580	795	24	is	be	AUX
cusj-5580	795	25	shown	show	VERB
cusj-5580	795	26	in	in	ADP
cusj-5580	795	27	fig	fig	NOUN
cusj-5580	795	28	.	.	PUNCT
cusj-5580	796	1	4	4	NUM
cusj-5580	796	2	.	.	X
cusj-5580	797	1	_	_	PUNCT
cusj-5580	798	1	_	_	PUNCT
cusj-5580	799	1	_	_	PUNCT
cusj-5580	800	1	_	_	PUNCT
cusj-5580	801	1	_	_	PUNCT
cusj-5580	802	1	_	_	PUNCT
cusj-5580	803	1	_	_	PUNCT
cusj-5580	804	1	_	_	PUNCT
cusj-5580	805	1	_	_	PUNCT
cusj-5580	806	1	_	_	PUNCT
cusj-5580	807	1	_	_	PUNCT
cusj-5580	808	1	_	_	PUNCT
cusj-5580	809	1	_	_	PUNCT
cusj-5580	810	1	_	_	PUNCT
cusj-5580	811	1	_	_	PUNCT
cusj-5580	812	1	_	_	PUNCT
cusj-5580	813	1	_	_	PUNCT
cusj-5580	814	1	_	_	PUNCT
cusj-5580	815	1	_	_	PUNCT
cusj-5580	816	1	_	_	PUNCT
cusj-5580	817	1	_	_	PUNCT
cusj-5580	818	1	_	_	PUNCT
cusj-5580	819	1	_	_	PUNCT
cusj-5580	820	1	_	_	PUNCT
cusj-5580	821	1	_	_	PUNCT
cusj-5580	822	1	_	_	PUNCT
cusj-5580	823	1	_	_	PUNCT
cusj-5580	824	1	_	_	PUNCT
cusj-5580	825	1	_	_	PUNCT
cusj-5580	826	1	_	_	PUNCT
cusj-5580	827	1	_	_	PUNCT
cusj-5580	828	1	_	_	PUNCT
cusj-5580	829	1	_	_	PUNCT
cusj-5580	830	1	_	_	PUNCT
cusj-5580	831	1	_	_	PUNCT
cusj-5580	832	1	_	_	PUNCT
cusj-5580	833	1	_	_	PUNCT
cusj-5580	834	1	_	_	PUNCT
cusj-5580	835	1	_	_	PUNCT
cusj-5580	836	1	_	_	PUNCT
cusj-5580	837	1	_	_	PUNCT
cusj-5580	838	1	_	_	PUNCT
cusj-5580	839	1	_	_	PUNCT
cusj-5580	840	1	_	_	PUNCT
cusj-5580	841	1	_	_	PUNCT
cusj-5580	842	1	_	_	PUNCT
cusj-5580	843	1	_	_	PUNCT
cusj-5580	844	1	_	_	PUNCT
cusj-5580	845	1	_	_	PUNCT
cusj-5580	846	1	_	_	PUNCT
cusj-5580	847	1	_	_	PUNCT
cusj-5580	848	1	_	_	PUNCT
cusj-5580	849	1	_	_	PUNCT
cusj-5580	850	1	_	_	PUNCT
cusj-5580	851	1	_	_	PUNCT
cusj-5580	852	1	_	_	PUNCT
cusj-5580	853	1	_	_	PUNCT
cusj-5580	854	1	_	_	PUNCT
cusj-5580	855	1	_	_	PUNCT
cusj-5580	856	1	_	_	PUNCT
cusj-5580	857	1	_	_	PUNCT
cusj-5580	858	1	_	_	PUNCT
cusj-5580	859	1	_	_	PUNCT
cusj-5580	860	1	_	_	PUNCT
cusj-5580	861	1	_	_	PUNCT
cusj-5580	862	1	_	_	PUNCT
cusj-5580	863	1	_	_	PUNCT
cusj-5580	864	1	_	_	PUNCT
cusj-5580	865	1	_	_	PUNCT
cusj-5580	866	1	_	_	PUNCT
cusj-5580	867	1	_	_	PUNCT
cusj-5580	868	1	_	_	PUNCT
cusj-5580	869	1	_	_	PUNCT
cusj-5580	870	1	_	_	PUNCT
cusj-5580	871	1	_	_	PUNCT
cusj-5580	872	1	_	_	PUNCT
cusj-5580	873	1	_	_	PUNCT
cusj-5580	874	1	_	_	PUNCT
cusj-5580	875	1	_	_	PUNCT
cusj-5580	876	1	_	_	PUNCT
cusj-5580	876	2	cusj	cusj	VERB
cusj-5580	876	3	2019	2019	NUM
cusj-5580	876	4	_	_	PUNCT
cusj-5580	877	1	_	_	PUNCT
cusj-5580	878	1	_	_	PUNCT
cusj-5580	879	1	_	_	PUNCT
cusj-5580	880	1	_	_	PUNCT
cusj-5580	881	1	_	_	PUNCT
cusj-5580	882	1	_	_	PUNCT
cusj-5580	883	1	_	_	PUNCT
cusj-5580	884	1	_	_	PUNCT
cusj-5580	885	1	_	_	PUNCT
cusj-5580	886	1	_	_	PUNCT
cusj-5580	887	1	_	_	PUNCT
cusj-5580	888	1	_	_	PUNCT
cusj-5580	889	1	_	_	PUNCT
cusj-5580	890	1	_	_	PUNCT
cusj-5580	891	1	_	_	PUNCT
cusj-5580	892	1	_	_	PUNCT
cusj-5580	893	1	_	_	PUNCT
cusj-5580	894	1	_	_	PUNCT
cusj-5580	895	1	_	_	PUNCT
cusj-5580	896	1	_	_	PUNCT
cusj-5580	897	1	_	_	PUNCT
cusj-5580	898	1	_	_	PUNCT
cusj-5580	899	1	_	_	PUNCT
cusj-5580	900	1	_	_	PUNCT
cusj-5580	901	1	_	_	PUNCT
cusj-5580	902	1	_	_	PUNCT
cusj-5580	903	1	_	_	PUNCT
cusj-5580	904	1	_	_	PUNCT
cusj-5580	905	1	_	_	PUNCT
cusj-5580	906	1	_	_	PUNCT
cusj-5580	907	1	_	_	PUNCT
cusj-5580	908	1	_	_	PUNCT
cusj-5580	909	1	_	_	PUNCT
cusj-5580	910	1	_	_	PUNCT
cusj-5580	911	1	_	_	PUNCT
cusj-5580	912	1	_	_	PUNCT
cusj-5580	913	1	_	_	PUNCT
cusj-5580	914	1	_	_	PUNCT
cusj-5580	915	1	_	_	PUNCT
cusj-5580	916	1	_	_	PUNCT
cusj-5580	917	1	_	_	PUNCT
cusj-5580	918	1	_	_	PUNCT
cusj-5580	919	1	_	_	PUNCT
cusj-5580	920	1	_	_	PUNCT
cusj-5580	921	1	_	_	PUNCT
cusj-5580	922	1	_	_	PUNCT
cusj-5580	923	1	_	_	PUNCT
cusj-5580	924	1	_	_	PUNCT
cusj-5580	925	1	_	_	PUNCT
cusj-5580	926	1	_	_	PUNCT
cusj-5580	927	1	_	_	PUNCT
cusj-5580	928	1	_	_	PUNCT
cusj-5580	929	1	_	_	PUNCT
cusj-5580	930	1	_	_	PUNCT
cusj-5580	931	1	_	_	PUNCT
cusj-5580	932	1	_	_	PUNCT
cusj-5580	933	1	_	_	PUNCT
cusj-5580	934	1	_	_	PUNCT
cusj-5580	935	1	_	_	PUNCT
cusj-5580	936	1	_	_	PUNCT
cusj-5580	937	1	_	_	PUNCT
cusj-5580	938	1	_	_	PUNCT
cusj-5580	939	1	_	_	PUNCT
cusj-5580	940	1	_	_	PUNCT
cusj-5580	941	1	_	_	PUNCT
cusj-5580	942	1	_	_	PUNCT
cusj-5580	943	1	_	_	PUNCT
cusj-5580	944	1	_	_	PUNCT
cusj-5580	945	1	_	_	PUNCT
cusj-5580	946	1	_	_	PUNCT
cusj-5580	947	1	_	_	PUNCT
cusj-5580	948	1	_	_	PUNCT
cusj-5580	949	1	_	_	PUNCT
cusj-5580	950	1	_	_	PUNCT
cusj-5580	951	1	_	_	PUNCT
cusj-5580	952	1	_	_	PUNCT
cusj-5580	953	1	_	_	PUNCT
cusj-5580	954	1	_	_	PUNCT
cusj-5580	955	1	_	_	PUNCT
cusj-5580	956	1	_	_	PUNCT
cusj-5580	957	1	_	_	PUNCT
cusj-5580	958	1	_	_	PUNCT
cusj-5580	959	1	_	_	PUNCT
cusj-5580	960	1	_	_	PUNCT
cusj-5580	961	1	_	_	PUNCT
cusj-5580	962	1	_	_	PUNCT
cusj-5580	963	1	_	_	PUNCT
cusj-5580	964	1	_	_	PUNCT
cusj-5580	965	1	_	_	PUNCT
cusj-5580	966	1	25	25	NUM
cusj-5580	966	2	figure	figure	NOUN
cusj-5580	966	3	4	4	NUM
cusj-5580	966	4	.	.	NUM
cusj-5580	966	5	envisioned	envision	VERB
cusj-5580	966	6	process	process	NOUN
cusj-5580	966	7	flow	flow	NOUN
cusj-5580	966	8	diagram	diagram	NOUN
cusj-5580	966	9	for	for	ADP
cusj-5580	966	10	the	the	DET
cusj-5580	966	11	flow	flow	NOUN
cusj-5580	966	12	-	-	PUNCT
cusj-5580	966	13	based	base	VERB
cusj-5580	966	14	buchwald	buchwald	ADJ
cusj-5580	966	15	synthesis	synthesis	NOUN
cusj-5580	966	16	of	of	ADP
cusj-5580	966	17	nilotinib	nilotinib	NOUN
cusj-5580	966	18	using	use	VERB
cusj-5580	966	19	packed	packed	ADJ
cusj-5580	966	20	bed	bed	NOUN
cusj-5580	966	21	reactors	reactor	NOUN
cusj-5580	966	22	.	.	PUNCT
cusj-5580	967	1	firstly	firstly	ADV
cusj-5580	967	2	,	,	PUNCT
cusj-5580	967	3	we	we	PRON
cusj-5580	967	4	re	re	VERB
cusj-5580	967	5	-	-	VERB
cusj-5580	967	6	designed	design	VERB
cusj-5580	967	7	the	the	DET
cusj-5580	967	8	reaction	reaction	NOUN
cusj-5580	967	9	scheme	scheme	NOUN
cusj-5580	967	10	of	of	ADP
cusj-5580	967	11	the	the	DET
cusj-5580	967	12	buchwald	buchwald	ADJ
cusj-5580	967	13	synthesis	synthesis	NOUN
cusj-5580	967	14	to	to	PART
cusj-5580	967	15	take	take	VERB
cusj-5580	967	16	place	place	NOUN
cusj-5580	967	17	under	under	ADP
cusj-5580	967	18	flow	flow	NOUN
cusj-5580	967	19	chemistry	chemistry	NOUN
cusj-5580	967	20	conditions	condition	NOUN
cusj-5580	967	21	(	(	PUNCT
cusj-5580	967	22	rather	rather	ADV
cusj-5580	967	23	than	than	ADP
cusj-5580	967	24	a	a	DET
cusj-5580	967	25	multi	multi	ADJ
cusj-5580	967	26	-	-	ADJ
cusj-5580	967	27	stage	stage	ADJ
cusj-5580	967	28	batch	batch	NOUN
cusj-5580	967	29	series	series	NOUN
cusj-5580	967	30	)	)	PUNCT
cusj-5580	967	31	.	.	PUNCT
cusj-5580	968	1	this	this	PRON
cusj-5580	968	2	should	should	AUX
cusj-5580	968	3	allow	allow	VERB
cusj-5580	968	4	for	for	ADP
cusj-5580	968	5	:	:	PUNCT
cusj-5580	968	6	(	(	PUNCT
cusj-5580	968	7	1	1	X
cusj-5580	968	8	)	)	PUNCT
cusj-5580	968	9	greater	great	ADJ
cusj-5580	968	10	efficiency	efficiency	NOUN
cusj-5580	968	11	by	by	ADP
cusj-5580	968	12	reducing	reduce	VERB
cusj-5580	968	13	manual	manual	ADJ
cusj-5580	968	14	mass	mass	NOUN
cusj-5580	968	15	transfers	transfer	NOUN
cusj-5580	968	16	between	between	ADP
cusj-5580	968	17	batch	batch	NOUN
cusj-5580	968	18	reactors	reactor	NOUN
cusj-5580	968	19	,	,	PUNCT
cusj-5580	968	20	(	(	PUNCT
cusj-5580	968	21	2	2	X
cusj-5580	968	22	)	)	PUNCT
cusj-5580	968	23	greater	great	ADJ
cusj-5580	968	24	degree	degree	NOUN
cusj-5580	968	25	of	of	ADP
cusj-5580	968	26	process	process	NOUN
cusj-5580	968	27	control	control	NOUN
cusj-5580	968	28	over	over	ADP
cusj-5580	968	29	the	the	DET
cusj-5580	968	30	synthesis	synthesis	NOUN
cusj-5580	968	31	wherein	wherein	ADV
cusj-5580	968	32	controlling	control	VERB
cusj-5580	968	33	reaction	reaction	NOUN
cusj-5580	968	34	flow	flow	NOUN
cusj-5580	968	35	rates	rate	NOUN
cusj-5580	968	36	will	will	AUX
cusj-5580	968	37	be	be	AUX
cusj-5580	968	38	the	the	DET
cusj-5580	968	39	key	key	ADJ
cusj-5580	968	40	concern	concern	NOUN
cusj-5580	968	41	,	,	PUNCT
cusj-5580	968	42	(	(	PUNCT
cusj-5580	968	43	3	3	X
cusj-5580	968	44	)	)	PUNCT
cusj-5580	968	45	greater	great	ADJ
cusj-5580	968	46	degree	degree	NOUN
cusj-5580	968	47	of	of	ADP
cusj-5580	968	48	safety	safety	NOUN
cusj-5580	968	49	by	by	ADP
cusj-5580	968	50	minimizing	minimize	VERB
cusj-5580	968	51	the	the	DET
cusj-5580	968	52	need	need	NOUN
cusj-5580	968	53	for	for	ADP
cusj-5580	968	54	reactor	reactor	NOUN
cusj-5580	968	55	transfers	transfer	NOUN
cusj-5580	968	56	and	and	CCONJ
cusj-5580	968	57	thus	thus	ADV
cusj-5580	968	58	eliminating	eliminate	VERB
cusj-5580	968	59	unnecessary	unnecessary	ADJ
cusj-5580	968	60	exposure	exposure	NOUN
cusj-5580	968	61	to	to	ADP
cusj-5580	968	62	dangerous	dangerous	ADJ
cusj-5580	968	63	solvents	solvent	NOUN
cusj-5580	968	64	,	,	PUNCT
cusj-5580	968	65	(	(	PUNCT
cusj-5580	968	66	4	4	X
cusj-5580	968	67	)	)	PUNCT
cusj-5580	968	68	greater	great	ADJ
cusj-5580	968	69	scalability	scalability	NOUN
cusj-5580	968	70	of	of	ADP
cusj-5580	968	71	the	the	DET
cusj-5580	968	72	reaction	reaction	NOUN
cusj-5580	968	73	to	to	ADP
cusj-5580	968	74	an	an	DET
cusj-5580	968	75	industrial	industrial	ADJ
cusj-5580	968	76	scale	scale	NOUN
cusj-5580	968	77	.	.	PUNCT
cusj-5580	969	1	the	the	DET
cusj-5580	969	2	buchwald	buchwald	ADJ
cusj-5580	969	3	synthesis	synthesis	NOUN
cusj-5580	969	4	requires	require	VERB
cusj-5580	969	5	palladium	palladium	NOUN
cusj-5580	969	6	and	and	CCONJ
cusj-5580	969	7	cesium	cesium	NOUN
cusj-5580	969	8	solid	solid	ADJ
cusj-5580	969	9	-	-	PUNCT
cusj-5580	969	10	state	state	NOUN
cusj-5580	969	11	catalysts	catalyst	NOUN
cusj-5580	969	12	at	at	ADP
cusj-5580	969	13	several	several	ADJ
cusj-5580	969	14	stages	stage	NOUN
cusj-5580	969	15	.	.	PUNCT
cusj-5580	970	1	to	to	PART
cusj-5580	970	2	address	address	VERB
cusj-5580	970	3	this	this	DET
cusj-5580	970	4	challenge	challenge	NOUN
cusj-5580	970	5	within	within	ADP
cusj-5580	970	6	the	the	DET
cusj-5580	970	7	scope	scope	NOUN
cusj-5580	970	8	of	of	ADP
cusj-5580	970	9	the	the	DET
cusj-5580	970	10	flow	flow	NOUN
cusj-5580	970	11	-	-	PUNCT
cusj-5580	970	12	based	base	VERB
cusj-5580	970	13	model	model	NOUN
cusj-5580	970	14	and	and	CCONJ
cusj-5580	970	15	make	make	VERB
cusj-5580	970	16	the	the	DET
cusj-5580	970	17	use	use	NOUN
cusj-5580	970	18	of	of	ADP
cusj-5580	970	19	such	such	ADJ
cusj-5580	970	20	catalysts	catalyst	NOUN
cusj-5580	970	21	feasible	feasible	ADJ
cusj-5580	970	22	on	on	ADP
cusj-5580	970	23	an	an	DET
cusj-5580	970	24	industrial	industrial	ADJ
cusj-5580	970	25	scale	scale	NOUN
cusj-5580	970	26	,	,	PUNCT
cusj-5580	970	27	we	we	PRON
cusj-5580	970	28	have	have	AUX
cusj-5580	970	29	designed	design	VERB
cusj-5580	970	30	for	for	ADP
cusj-5580	970	31	the	the	DET
cusj-5580	970	32	implementation	implementation	NOUN
cusj-5580	970	33	of	of	ADP
cusj-5580	970	34	packed	packed	ADJ
cusj-5580	970	35	bed	bed	NOUN
cusj-5580	970	36	reactors	reactor	NOUN
cusj-5580	970	37	(	(	PUNCT
cusj-5580	970	38	pbrs	pbrs	NOUN
cusj-5580	970	39	)	)	PUNCT
cusj-5580	970	40	into	into	ADP
cusj-5580	970	41	our	our	PRON
cusj-5580	970	42	process	process	NOUN
cusj-5580	970	43	.	.	PUNCT
cusj-5580	971	1	this	this	PRON
cusj-5580	971	2	will	will	AUX
cusj-5580	971	3	allow	allow	VERB
cusj-5580	971	4	for	for	ADP
cusj-5580	971	5	the	the	DET
cusj-5580	971	6	large	large	ADJ
cusj-5580	971	7	-	-	PUNCT
cusj-5580	971	8	scale	scale	NOUN
cusj-5580	971	9	use	use	NOUN
cusj-5580	971	10	of	of	ADP
cusj-5580	971	11	the	the	DET
cusj-5580	971	12	solid	solid	ADJ
cusj-5580	971	13	-	-	PUNCT
cusj-5580	971	14	state	state	NOUN
cusj-5580	971	15	catalysts	catalyst	NOUN
cusj-5580	971	16	in	in	ADP
cusj-5580	971	17	the	the	DET
cusj-5580	971	18	reaction	reaction	NOUN
cusj-5580	971	19	under	under	ADP
cusj-5580	971	20	flow	flow	NOUN
cusj-5580	971	21	chemistry	chemistry	NOUN
cusj-5580	971	22	conditions	condition	NOUN
cusj-5580	971	23	while	while	SCONJ
cusj-5580	971	24	also	also	ADV
cusj-5580	971	25	facilitating	facilitate	VERB
cusj-5580	971	26	catalyst	catalyst	NOUN
cusj-5580	971	27	recovery	recovery	NOUN
cusj-5580	971	28	and	and	CCONJ
cusj-5580	971	29	cleaning	cleaning	NOUN
cusj-5580	971	30	.	.	PUNCT
cusj-5580	972	1	fig	fig	NOUN
cusj-5580	972	2	.	.	PUNCT
cusj-5580	973	1	5	5	NUM
cusj-5580	973	2	illustrates	illustrate	VERB
cusj-5580	973	3	the	the	DET
cusj-5580	973	4	final	final	ADJ
cusj-5580	973	5	process	process	NOUN
cusj-5580	973	6	flow	flow	NOUN
cusj-5580	973	7	sheet	sheet	NOUN
cusj-5580	973	8	that	that	PRON
cusj-5580	973	9	was	be	AUX
cusj-5580	973	10	constructed	construct	VERB
cusj-5580	973	11	in	in	ADP
cusj-5580	973	12	chemcad	chemcad	NOUN
cusj-5580	973	13	.	.	PUNCT
cusj-5580	974	1	it	it	PRON
cusj-5580	974	2	illustrates	illustrate	VERB
cusj-5580	974	3	the	the	DET
cusj-5580	974	4	components	component	NOUN
cusj-5580	974	5	entering	enter	VERB
cusj-5580	974	6	the	the	DET
cusj-5580	974	7	pbrs	pbrs	NOUN
cusj-5580	974	8	in	in	ADP
cusj-5580	974	9	each	each	DET
cusj-5580	974	10	stage	stage	NOUN
cusj-5580	974	11	of	of	ADP
cusj-5580	974	12	the	the	DET
cusj-5580	974	13	reaction	reaction	NOUN
cusj-5580	974	14	and	and	CCONJ
cusj-5580	974	15	distillation	distillation	NOUN
cusj-5580	974	16	towers	tower	NOUN
cusj-5580	974	17	for	for	ADP
cusj-5580	974	18	separation	separation	NOUN
cusj-5580	974	19	.	.	PUNCT
cusj-5580	975	1	the	the	DET
cusj-5580	975	2	model	model	NOUN
cusj-5580	975	3	successfully	successfully	ADV
cusj-5580	975	4	converged	converge	VERB
cusj-5580	975	5	with	with	ADP
cusj-5580	975	6	respect	respect	NOUN
cusj-5580	975	7	to	to	ADP
cusj-5580	975	8	the	the	DET
cusj-5580	975	9	mass	mass	NOUN
cusj-5580	975	10	and	and	CCONJ
cusj-5580	975	11	energy	energy	NOUN
cusj-5580	975	12	balances	balance	NOUN
cusj-5580	975	13	and	and	CCONJ
cusj-5580	975	14	was	be	AUX
cusj-5580	975	15	able	able	ADJ
cusj-5580	975	16	to	to	PART
cusj-5580	975	17	produce	produce	VERB
cusj-5580	975	18	nilotinib	nilotinib	NOUN
cusj-5580	975	19	at	at	ADP
cusj-5580	975	20	a	a	DET
cusj-5580	975	21	desired	desire	VERB
cusj-5580	975	22	rate	rate	NOUN
cusj-5580	975	23	that	that	PRON
cusj-5580	975	24	would	would	AUX
cusj-5580	975	25	allow	allow	VERB
cusj-5580	975	26	us	we	PRON
cusj-5580	975	27	to	to	PART
cusj-5580	975	28	achieve	achieve	VERB
cusj-5580	975	29	the	the	DET
cusj-5580	975	30	1150	1150	NUM
cusj-5580	975	31	kg	kg	NOUN
cusj-5580	975	32	/year	/year	PUNCT
cusj-5580	976	1	design	design	NOUN
cusj-5580	976	2	basis	basis	NOUN
cusj-5580	976	3	goal	goal	NOUN
cusj-5580	976	4	.	.	PUNCT
cusj-5580	977	1	furthermore	furthermore	ADV
cusj-5580	977	2	,	,	PUNCT
cusj-5580	977	3	according	accord	VERB
cusj-5580	977	4	to	to	ADP
cusj-5580	977	5	the	the	DET
cusj-5580	977	6	chemcad	chemcad	NOUN
cusj-5580	977	7	model	model	NOUN
cusj-5580	977	8	,	,	PUNCT
cusj-5580	977	9	the	the	DET
cusj-5580	977	10	final	final	ADJ
cusj-5580	977	11	distillation	distillation	NOUN
cusj-5580	977	12	tower	tower	NOUN
cusj-5580	977	13	of	of	ADP
cusj-5580	977	14	nilotinib	nilotinib	NOUN
cusj-5580	977	15	production	production	NOUN
cusj-5580	977	16	achieved	achieve	VERB
cusj-5580	977	17	over	over	ADP
cusj-5580	977	18	98	98	NUM
cusj-5580	977	19	%	%	NOUN
cusj-5580	977	20	separation	separation	NOUN
cusj-5580	977	21	,	,	PUNCT
cusj-5580	977	22	indicating	indicate	VERB
cusj-5580	977	23	the	the	DET
cusj-5580	977	24	robust	robust	ADJ
cusj-5580	977	25	final	final	ADJ
cusj-5580	977	26	purity	purity	NOUN
cusj-5580	977	27	of	of	ADP
cusj-5580	977	28	our	our	PRON
cusj-5580	977	29	desired	desire	VERB
cusj-5580	977	30	nilotinib	nilotinib	NOUN
cusj-5580	977	31	product	product	NOUN
cusj-5580	977	32	.	.	PUNCT
cusj-5580	978	1	to	to	PART
cusj-5580	978	2	produce	produce	VERB
cusj-5580	978	3	our	our	PRON
cusj-5580	978	4	desired	desire	VERB
cusj-5580	978	5	output	output	NOUN
cusj-5580	978	6	of	of	ADP
cusj-5580	978	7	1150	1150	NUM
cusj-5580	978	8	kg	kg	NOUN
cusj-5580	978	9	of	of	ADP
cusj-5580	978	10	nilotinib	nilotinib	NOUN
cusj-5580	978	11	per	per	ADP
cusj-5580	978	12	year	year	NOUN
cusj-5580	978	13	,	,	PUNCT
cusj-5580	978	14	we	we	PRON
cusj-5580	978	15	approximate	approximate	VERB
cusj-5580	978	16	that	that	SCONJ
cusj-5580	978	17	our	our	PRON
cusj-5580	978	18	plant	plant	NOUN
cusj-5580	978	19	will	will	AUX
cusj-5580	978	20	need	need	VERB
cusj-5580	978	21	to	to	PART
cusj-5580	978	22	run	run	VERB
cusj-5580	978	23	for	for	ADP
cusj-5580	978	24	at	at	ADV
cusj-5580	978	25	least	least	ADV
cusj-5580	978	26	350	350	NUM
cusj-5580	978	27	days	day	NOUN
cusj-5580	978	28	of	of	ADP
cusj-5580	978	29	the	the	DET
cusj-5580	978	30	year	year	NOUN
cusj-5580	978	31	.	.	PUNCT
cusj-5580	979	1	assuming	assume	VERB
cusj-5580	979	2	constant	constant	ADJ
cusj-5580	979	3	production	production	NOUN
cusj-5580	979	4	,	,	PUNCT
cusj-5580	979	5	a	a	DET
cusj-5580	979	6	minimum	minimum	ADJ
cusj-5580	979	7	output	output	NOUN
cusj-5580	979	8	of	of	ADP
cusj-5580	979	9	137	137	NUM
cusj-5580	979	10	g	g	NOUN
cusj-5580	979	11	/	/	SYM
cusj-5580	979	12	hour	hour	NOUN
cusj-5580	979	13	(	(	PUNCT
cusj-5580	979	14	0.263	0.263	NUM
cusj-5580	979	15	moles	mole	NOUN
cusj-5580	979	16	)	)	PUNCT
cusj-5580	979	17	of	of	ADP
cusj-5580	979	18	nilotinib	nilotinib	NOUN
cusj-5580	979	19	is	be	AUX
cusj-5580	979	20	required	require	VERB
cusj-5580	979	21	.	.	PUNCT
cusj-5580	980	1	due	due	ADP
cusj-5580	980	2	to	to	ADP
cusj-5580	980	3	the	the	DET
cusj-5580	980	4	conversion	conversion	NOUN
cusj-5580	980	5	rates	rate	NOUN
cusj-5580	980	6	of	of	ADP
cusj-5580	980	7	90	90	NUM
cusj-5580	980	8	%	%	NOUN
cusj-5580	980	9	,	,	PUNCT
cusj-5580	980	10	95	95	NUM
cusj-5580	980	11	%	%	NOUN
cusj-5580	980	12	,	,	PUNCT
cusj-5580	980	13	and	and	CCONJ
cusj-5580	980	14	90	90	NUM
cusj-5580	980	15	%	%	NOUN
cusj-5580	980	16	for	for	ADP
cusj-5580	980	17	each	each	PRON
cusj-5580	980	18	of	of	ADP
cusj-5580	980	19	the	the	DET
cusj-5580	980	20	three	three	NUM
cusj-5580	980	21	stages	stage	NOUN
cusj-5580	980	22	of	of	ADP
cusj-5580	980	23	the	the	DET
cusj-5580	980	24	buchwald	buchwald	ADJ
cusj-5580	980	25	synthesis	synthesis	NOUN
cusj-5580	980	26	,	,	PUNCT
cusj-5580	980	27	respectively	respectively	ADV
cusj-5580	980	28	,	,	PUNCT
cusj-5580	980	29	that	that	PRON
cusj-5580	980	30	translates	translate	VERB
cusj-5580	980	31	to	to	ADP
cusj-5580	980	32	a	a	DET
cusj-5580	980	33	basis	basis	NOUN
cusj-5580	980	34	of	of	ADP
cusj-5580	980	35	approximately	approximately	ADV
cusj-5580	980	36	0.325	0.325	NUM
cusj-5580	980	37	mol	mol	PROPN
cusj-5580	980	38	/	/	SYM
cusj-5580	980	39	hr	hr	NOUN
cusj-5580	980	40	for	for	ADP
cusj-5580	980	41	the	the	DET
cusj-5580	980	42	starting	starting	NOUN
cusj-5580	980	43	reactants	reactant	NOUN
cusj-5580	980	44	of	of	ADP
cusj-5580	980	45	both	both	DET
cusj-5580	980	46	initial	initial	ADJ
cusj-5580	980	47	reactions	reaction	NOUN
cusj-5580	980	48	,	,	PUNCT
cusj-5580	980	49	with	with	SCONJ
cusj-5580	980	50	mole	mole	NOUN
cusj-5580	980	51	equivalencies	equivalencie	NOUN
cusj-5580	980	52	accounted	account	VERB
cusj-5580	980	53	for	for	ADP
cusj-5580	980	54	appropriately	appropriately	ADV
cusj-5580	980	55	.	.	PUNCT
cusj-5580	981	1	a	a	DET
cusj-5580	981	2	table	table	NOUN
cusj-5580	981	3	detailing	detail	VERB
cusj-5580	981	4	the	the	DET
cusj-5580	981	5	mass	mass	NOUN
cusj-5580	981	6	balance	balance	NOUN
cusj-5580	981	7	from	from	ADP
cusj-5580	981	8	our	our	PRON
cusj-5580	981	9	reactor	reactor	NOUN
cusj-5580	981	10	system	system	NOUN
cusj-5580	981	11	designed	design	VERB
cusj-5580	981	12	in	in	ADP
cusj-5580	981	13	chemcad	chemcad	NOUN
cusj-5580	981	14	is	be	AUX
cusj-5580	981	15	shown	show	VERB
cusj-5580	981	16	in	in	ADP
cusj-5580	981	17	table	table	NOUN
cusj-5580	981	18	2	2	NUM
cusj-5580	981	19	.	.	PUNCT
cusj-5580	982	1	here	here	ADV
cusj-5580	982	2	,	,	PUNCT
cusj-5580	982	3	an	an	DET
cusj-5580	982	4	output	output	NOUN
cusj-5580	982	5	of	of	ADP
cusj-5580	982	6	138	138	NUM
cusj-5580	982	7	g	g	NOUN
cusj-5580	982	8	/	/	SYM
cusj-5580	982	9	hr	hr	NOUN
cusj-5580	982	10	is	be	AUX
cusj-5580	982	11	shown	show	VERB
cusj-5580	982	12	,	,	PUNCT
cusj-5580	982	13	successfully	successfully	ADV
cusj-5580	982	14	achieving	achieve	VERB
cusj-5580	982	15	our	our	PRON
cusj-5580	982	16	design	design	NOUN
cusj-5580	982	17	basis	basis	NOUN
cusj-5580	982	18	of	of	ADP
cusj-5580	982	19	1150	1150	NUM
cusj-5580	982	20	kg	kg	NOUN
cusj-5580	982	21	per	per	ADP
cusj-5580	982	22	year	year	NOUN
cusj-5580	982	23	.	.	PUNCT
cusj-5580	983	1	additionally	additionally	ADV
cusj-5580	983	2	,	,	PUNCT
cusj-5580	983	3	very	very	ADV
cusj-5580	983	4	little	little	ADJ
cusj-5580	983	5	accumulation	accumulation	NOUN
cusj-5580	983	6	is	be	AUX
cusj-5580	983	7	shown	show	VERB
cusj-5580	983	8	,	,	PUNCT
cusj-5580	983	9	as	as	SCONJ
cusj-5580	983	10	evidenced	evidence	VERB
cusj-5580	983	11	by	by	ADP
cusj-5580	983	12	the	the	DET
cusj-5580	983	13	near	near	ADJ
cusj-5580	983	14	identical	identical	ADJ
cusj-5580	983	15	input	input	NOUN
cusj-5580	983	16	/	/	SYM
cusj-5580	983	17	output	output	NOUN
cusj-5580	983	18	masses	masse	NOUN
cusj-5580	983	19	.	.	PUNCT
cusj-5580	984	1	the	the	DET
cusj-5580	984	2	energy	energy	NOUN
cusj-5580	984	3	balance	balance	NOUN
cusj-5580	984	4	from	from	ADP
cusj-5580	984	5	the	the	DET
cusj-5580	984	6	reactor	reactor	NOUN
cusj-5580	984	7	process	process	NOUN
cusj-5580	984	8	,	,	PUNCT
cusj-5580	984	9	including	include	VERB
cusj-5580	984	10	energy	energy	NOUN
cusj-5580	984	11	added	add	VERB
cusj-5580	984	12	by	by	ADP
cusj-5580	984	13	each	each	DET
cusj-5580	984	14	distillation	distillation	NOUN
cusj-5580	984	15	tower	tower	NOUN
cusj-5580	984	16	,	,	PUNCT
cusj-5580	984	17	is	be	AUX
cusj-5580	984	18	also	also	ADV
cusj-5580	984	19	shown	show	VERB
cusj-5580	984	20	in	in	ADP
cusj-5580	984	21	table	table	NOUN
cusj-5580	984	22	3	3	NUM
cusj-5580	984	23	.	.	PUNCT
cusj-5580	984	24	figure	figure	NOUN
cusj-5580	984	25	5	5	NUM
cusj-5580	984	26	.	.	PUNCT
cusj-5580	984	27	final	final	ADJ
cusj-5580	984	28	process	process	NOUN
cusj-5580	984	29	flow	flow	NOUN
cusj-5580	984	30	sheet	sheet	NOUN
cusj-5580	984	31	for	for	ADP
cusj-5580	984	32	synthesis	synthesis	NOUN
cusj-5580	984	33	of	of	ADP
cusj-5580	984	34	nilotinib	nilotinib	NOUN
cusj-5580	984	35	as	as	SCONJ
cusj-5580	984	36	constructed	construct	VERB
cusj-5580	984	37	by	by	ADP
cusj-5580	984	38	chemcad	chemcad	PROPN
cusj-5580	984	39	.	.	PUNCT
cusj-5580	985	1	cusj	cusj	PROPN
cusj-5580	985	2	2019	2019	NUM
cusj-5580	985	3	_	_	PUNCT
cusj-5580	986	1	_	_	PUNCT
cusj-5580	987	1	_	_	PUNCT
cusj-5580	988	1	_	_	PUNCT
cusj-5580	989	1	_	_	PUNCT
cusj-5580	990	1	_	_	PUNCT
cusj-5580	991	1	_	_	PUNCT
cusj-5580	992	1	_	_	PUNCT
cusj-5580	993	1	_	_	PUNCT
cusj-5580	994	1	_	_	PUNCT
cusj-5580	995	1	_	_	PUNCT
cusj-5580	996	1	_	_	PUNCT
cusj-5580	997	1	_	_	PUNCT
cusj-5580	998	1	_	_	PUNCT
cusj-5580	999	1	_	_	PUNCT
cusj-5580	1000	1	_	_	PUNCT
cusj-5580	1001	1	_	_	PUNCT
cusj-5580	1002	1	_	_	PUNCT
cusj-5580	1003	1	_	_	PUNCT
cusj-5580	1004	1	_	_	PUNCT
cusj-5580	1005	1	_	_	PUNCT
cusj-5580	1006	1	_	_	PUNCT
cusj-5580	1007	1	_	_	PUNCT
cusj-5580	1008	1	_	_	PUNCT
cusj-5580	1009	1	_	_	PUNCT
cusj-5580	1010	1	_	_	PUNCT
cusj-5580	1011	1	_	_	PUNCT
cusj-5580	1012	1	_	_	PUNCT
cusj-5580	1013	1	_	_	PUNCT
cusj-5580	1014	1	_	_	PUNCT
cusj-5580	1015	1	_	_	PUNCT
cusj-5580	1016	1	_	_	PUNCT
cusj-5580	1017	1	_	_	PUNCT
cusj-5580	1018	1	_	_	PUNCT
cusj-5580	1019	1	_	_	PUNCT
cusj-5580	1020	1	_	_	PUNCT
cusj-5580	1021	1	_	_	PUNCT
cusj-5580	1022	1	_	_	PUNCT
cusj-5580	1023	1	_	_	PUNCT
cusj-5580	1024	1	_	_	PUNCT
cusj-5580	1025	1	_	_	PUNCT
cusj-5580	1026	1	_	_	PUNCT
cusj-5580	1027	1	_	_	PUNCT
cusj-5580	1028	1	_	_	PUNCT
cusj-5580	1029	1	_	_	PUNCT
cusj-5580	1030	1	_	_	PUNCT
cusj-5580	1031	1	_	_	PUNCT
cusj-5580	1032	1	_	_	PUNCT
cusj-5580	1033	1	_	_	PUNCT
cusj-5580	1034	1	_	_	PUNCT
cusj-5580	1035	1	_	_	PUNCT
cusj-5580	1036	1	_	_	PUNCT
cusj-5580	1037	1	_	_	PUNCT
cusj-5580	1038	1	_	_	PUNCT
cusj-5580	1039	1	_	_	PUNCT
cusj-5580	1040	1	_	_	PUNCT
cusj-5580	1041	1	_	_	PUNCT
cusj-5580	1042	1	_	_	PUNCT
cusj-5580	1043	1	_	_	PUNCT
cusj-5580	1044	1	_	_	PUNCT
cusj-5580	1045	1	_	_	PUNCT
cusj-5580	1046	1	_	_	PUNCT
cusj-5580	1047	1	_	_	PUNCT
cusj-5580	1048	1	_	_	PUNCT
cusj-5580	1049	1	_	_	PUNCT
cusj-5580	1050	1	_	_	PUNCT
cusj-5580	1051	1	_	_	PUNCT
cusj-5580	1052	1	_	_	PUNCT
cusj-5580	1053	1	_	_	PUNCT
cusj-5580	1054	1	_	_	PUNCT
cusj-5580	1055	1	_	_	PUNCT
cusj-5580	1056	1	_	_	PUNCT
cusj-5580	1057	1	_	_	PUNCT
cusj-5580	1058	1	_	_	PUNCT
cusj-5580	1059	1	_	_	PUNCT
cusj-5580	1060	1	_	_	PUNCT
cusj-5580	1061	1	_	_	PUNCT
cusj-5580	1062	1	_	_	PUNCT
cusj-5580	1063	1	_	_	PUNCT
cusj-5580	1064	1	_	_	PUNCT
cusj-5580	1065	1	_	_	PUNCT
cusj-5580	1066	1	_	_	PUNCT
cusj-5580	1067	1	_	_	PUNCT
cusj-5580	1068	1	_	_	PUNCT
cusj-5580	1069	1	_	_	PUNCT
cusj-5580	1070	1	_	_	PUNCT
cusj-5580	1071	1	_	_	PUNCT
cusj-5580	1072	1	_	_	PUNCT
cusj-5580	1073	1	_	_	PUNCT
cusj-5580	1074	1	_	_	PUNCT
cusj-5580	1075	1	_	_	PUNCT
cusj-5580	1076	1	_	_	PUNCT
cusj-5580	1077	1	_	_	PUNCT
cusj-5580	1078	1	_	_	PUNCT
cusj-5580	1079	1	_	_	PUNCT
cusj-5580	1080	1	_	_	PUNCT
cusj-5580	1081	1	_	_	PUNCT
cusj-5580	1082	1	_	_	PUNCT
cusj-5580	1083	1	_	_	PUNCT
cusj-5580	1084	1	_	_	PUNCT
cusj-5580	1085	1	_	_	PUNCT
cusj-5580	1086	1	_	_	PUNCT
cusj-5580	1087	1	_	_	PUNCT
cusj-5580	1088	1	_	_	PUNCT
cusj-5580	1089	1	_	_	PUNCT
cusj-5580	1090	1	_	_	PUNCT
cusj-5580	1091	1	_	_	PUNCT
cusj-5580	1092	1	_	_	PUNCT
cusj-5580	1093	1	_	_	PUNCT
cusj-5580	1094	1	_	_	PUNCT
cusj-5580	1095	1	_	_	PUNCT
cusj-5580	1096	1	_	_	PUNCT
cusj-5580	1097	1	_	_	PUNCT
cusj-5580	1098	1	_	_	PUNCT
cusj-5580	1099	1	_	_	PUNCT
cusj-5580	1100	1	_	_	PUNCT
cusj-5580	1101	1	_	_	PUNCT
cusj-5580	1102	1	_	_	PUNCT
cusj-5580	1103	1	_	_	PUNCT
cusj-5580	1104	1	_	_	PUNCT
cusj-5580	1105	1	_	_	PUNCT
cusj-5580	1106	1	_	_	PUNCT
cusj-5580	1107	1	_	_	PUNCT
cusj-5580	1108	1	_	_	PUNCT
cusj-5580	1109	1	_	_	PUNCT
cusj-5580	1110	1	_	_	PUNCT
cusj-5580	1111	1	_	_	PUNCT
cusj-5580	1112	1	_	_	PUNCT
cusj-5580	1113	1	_	_	PUNCT
cusj-5580	1114	1	_	_	PUNCT
cusj-5580	1115	1	_	_	PUNCT
cusj-5580	1116	1	_	_	PUNCT
cusj-5580	1117	1	_	_	PUNCT
cusj-5580	1118	1	_	_	PUNCT
cusj-5580	1119	1	_	_	PUNCT
cusj-5580	1120	1	_	_	PUNCT
cusj-5580	1121	1	_	_	PUNCT
cusj-5580	1122	1	_	_	PUNCT
cusj-5580	1123	1	_	_	PUNCT
cusj-5580	1124	1	_	_	PUNCT
cusj-5580	1125	1	_	_	PUNCT
cusj-5580	1126	1	_	_	PUNCT
cusj-5580	1127	1	_	_	PUNCT
cusj-5580	1128	1	_	_	PUNCT
cusj-5580	1129	1	_	_	PUNCT
cusj-5580	1130	1	_	_	PUNCT
cusj-5580	1131	1	_	_	PUNCT
cusj-5580	1132	1	_	_	PUNCT
cusj-5580	1133	1	_	_	PUNCT
cusj-5580	1134	1	_	_	PUNCT
cusj-5580	1135	1	_	_	PUNCT
cusj-5580	1136	1	_	_	PUNCT
cusj-5580	1137	1	_	_	PUNCT
cusj-5580	1138	1	_	_	PUNCT
cusj-5580	1139	1	_	_	PUNCT
cusj-5580	1140	1	_	_	PUNCT
cusj-5580	1141	1	_	_	PUNCT
cusj-5580	1142	1	_	_	PUNCT
cusj-5580	1143	1	_	_	PUNCT
cusj-5580	1144	1	_	_	PUNCT
cusj-5580	1145	1	_	_	PUNCT
cusj-5580	1146	1	_	_	PUNCT
cusj-5580	1147	1	_	_	PUNCT
cusj-5580	1148	1	_	_	PUNCT
cusj-5580	1149	1	_	_	PUNCT
cusj-5580	1150	1	_	_	PUNCT
cusj-5580	1151	1	_	_	PUNCT
cusj-5580	1152	1	_	_	PUNCT
cusj-5580	1153	1	_	_	PUNCT
cusj-5580	1154	1	_	_	PUNCT
cusj-5580	1155	1	26	26	NUM
cusj-5580	1155	2	table	table	NOUN
cusj-5580	1155	3	2	2	NUM
cusj-5580	1155	4	.	.	PUNCT
cusj-5580	1155	5	chemcad	chemcad	NOUN
cusj-5580	1155	6	report	report	NOUN
cusj-5580	1155	7	of	of	ADP
cusj-5580	1155	8	overall	overall	ADJ
cusj-5580	1155	9	mass	mass	ADJ
cusj-5580	1155	10	balance	balance	NOUN
cusj-5580	1155	11	.	.	PUNCT
cusj-5580	1155	12	table	table	NOUN
cusj-5580	1155	13	3	3	NUM
cusj-5580	1155	14	.	.	PUNCT
cusj-5580	1156	1	chemcad	chemcad	NOUN
cusj-5580	1156	2	report	report	NOUN
cusj-5580	1156	3	of	of	ADP
cusj-5580	1156	4	overall	overall	ADJ
cusj-5580	1156	5	energy	energy	NOUN
cusj-5580	1156	6	balance	balance	NOUN
cusj-5580	1156	7	.	.	PUNCT
cusj-5580	1157	1	similar	similar	ADJ
cusj-5580	1157	2	to	to	ADP
cusj-5580	1157	3	the	the	DET
cusj-5580	1157	4	mass	mass	NOUN
cusj-5580	1157	5	balance	balance	NOUN
cusj-5580	1157	6	,	,	PUNCT
cusj-5580	1157	7	it	it	PRON
cusj-5580	1157	8	is	be	AUX
cusj-5580	1157	9	evident	evident	ADJ
cusj-5580	1157	10	that	that	SCONJ
cusj-5580	1157	11	an	an	DET
cusj-5580	1157	12	almost	almost	ADV
cusj-5580	1157	13	perfect	perfect	ADJ
cusj-5580	1157	14	energy	energy	NOUN
cusj-5580	1157	15	balance	balance	NOUN
cusj-5580	1157	16	is	be	AUX
cusj-5580	1157	17	achieved	achieve	VERB
cusj-5580	1157	18	,	,	PUNCT
cusj-5580	1157	19	indicating	indicate	VERB
cusj-5580	1157	20	the	the	DET
cusj-5580	1157	21	convergence	convergence	NOUN
cusj-5580	1157	22	success	success	NOUN
cusj-5580	1157	23	of	of	ADP
cusj-5580	1157	24	our	our	PRON
cusj-5580	1157	25	chemcad	chemcad	NOUN
cusj-5580	1157	26	model	model	NOUN
cusj-5580	1157	27	.	.	PUNCT
cusj-5580	1158	1	this	this	DET
cusj-5580	1158	2	mass	mass	NOUN
cusj-5580	1158	3	and	and	CCONJ
cusj-5580	1158	4	energy	energy	NOUN
cusj-5580	1158	5	balance	balance	NOUN
cusj-5580	1158	6	from	from	ADP
cusj-5580	1158	7	the	the	DET
cusj-5580	1158	8	chemcad	chemcad	NOUN
cusj-5580	1158	9	model	model	NOUN
cusj-5580	1158	10	serves	serve	VERB
cusj-5580	1158	11	to	to	PART
cusj-5580	1158	12	highlight	highlight	VERB
cusj-5580	1158	13	that	that	SCONJ
cusj-5580	1158	14	our	our	PRON
cusj-5580	1158	15	industrial	industrial	ADJ
cusj-5580	1158	16	scaled	scale	VERB
cusj-5580	1158	17	synthesis	synthesis	NOUN
cusj-5580	1158	18	of	of	ADP
cusj-5580	1158	19	nilotinib	nilotinib	NOUN
cusj-5580	1158	20	using	use	VERB
cusj-5580	1158	21	the	the	DET
cusj-5580	1158	22	buchwald	buchwald	ADJ
cusj-5580	1158	23	synthesis	synthesis	NOUN
cusj-5580	1158	24	was	be	AUX
cusj-5580	1158	25	successful	successful	ADJ
cusj-5580	1158	26	and	and	CCONJ
cusj-5580	1158	27	that	that	SCONJ
cusj-5580	1158	28	,	,	PUNCT
cusj-5580	1158	29	computationally	computationally	ADV
cusj-5580	1158	30	,	,	PUNCT
cusj-5580	1158	31	there	there	PRON
cusj-5580	1158	32	is	be	VERB
cusj-5580	1158	33	strong	strong	ADJ
cusj-5580	1158	34	evidence	evidence	NOUN
cusj-5580	1158	35	to	to	PART
cusj-5580	1158	36	indicate	indicate	VERB
cusj-5580	1158	37	that	that	SCONJ
cusj-5580	1158	38	this	this	DET
cusj-5580	1158	39	process	process	NOUN
cusj-5580	1158	40	can	can	AUX
cusj-5580	1158	41	be	be	AUX
cusj-5580	1158	42	scaled	scale	VERB
cusj-5580	1158	43	to	to	PART
cusj-5580	1158	44	effectively	effectively	ADV
cusj-5580	1158	45	produce	produce	VERB
cusj-5580	1158	46	at	at	ADV
cusj-5580	1158	47	least	least	ADV
cusj-5580	1158	48	1150	1150	NUM
cusj-5580	1158	49	kg	kg	NOUN
cusj-5580	1158	50	of	of	ADP
cusj-5580	1158	51	nilotinib	nilotinib	NOUN
cusj-5580	1158	52	per	per	ADP
cusj-5580	1158	53	year	year	NOUN
cusj-5580	1158	54	.	.	PUNCT
cusj-5580	1159	1	given	give	VERB
cusj-5580	1159	2	our	our	PRON
cusj-5580	1159	3	flow	flow	NOUN
cusj-5580	1159	4	-	-	PUNCT
cusj-5580	1159	5	based	base	VERB
cusj-5580	1159	6	design	design	NOUN
cusj-5580	1159	7	and	and	CCONJ
cusj-5580	1159	8	the	the	DET
cusj-5580	1159	9	nature	nature	NOUN
cusj-5580	1159	10	of	of	ADP
cusj-5580	1159	11	the	the	DET
cusj-5580	1159	12	buchwald	buchwald	ADJ
cusj-5580	1159	13	synthesis	synthesis	NOUN
cusj-5580	1159	14	itself	itself	PRON
cusj-5580	1159	15	,	,	PUNCT
cusj-5580	1159	16	this	this	PRON
cusj-5580	1159	17	represents	represent	VERB
cusj-5580	1159	18	a	a	DET
cusj-5580	1159	19	great	great	ADJ
cusj-5580	1159	20	improvement	improvement	NOUN
cusj-5580	1159	21	with	with	ADP
cusj-5580	1159	22	respect	respect	NOUN
cusj-5580	1159	23	to	to	ADP
cusj-5580	1159	24	the	the	DET
cusj-5580	1159	25	time	time	NOUN
cusj-5580	1159	26	,	,	PUNCT
cusj-5580	1159	27	safety	safety	NOUN
cusj-5580	1159	28	,	,	PUNCT
cusj-5580	1159	29	and	and	CCONJ
cusj-5580	1159	30	ease	ease	NOUN
cusj-5580	1159	31	of	of	ADP
cusj-5580	1159	32	nilotinib	nilotinib	NOUN
cusj-5580	1159	33	production	production	NOUN
cusj-5580	1159	34	as	as	SCONJ
cusj-5580	1159	35	compared	compare	VERB
cusj-5580	1159	36	to	to	ADP
cusj-5580	1159	37	the	the	DET
cusj-5580	1159	38	existing	exist	VERB
cusj-5580	1159	39	novartis	novartis	NOUN
cusj-5580	1159	40	methodology	methodology	NOUN
cusj-5580	1159	41	.	.	PUNCT
cusj-5580	1160	1	b.	b.	PROPN
cusj-5580	1160	2	process	process	NOUN
cusj-5580	1160	3	economics	economic	NOUN
cusj-5580	1160	4	process	process	NOUN
cusj-5580	1160	5	economics	economic	NOUN
cusj-5580	1160	6	of	of	ADP
cusj-5580	1160	7	the	the	DET
cusj-5580	1160	8	scaled	scale	VERB
cusj-5580	1160	9	buchwald	buchwald	NOUN
cusj-5580	1160	10	synthesis	synthesis	NOUN
cusj-5580	1160	11	i.	i.	NOUN
cusj-5580	1160	12	capital	capital	NOUN
cusj-5580	1160	13	and	and	CCONJ
cusj-5580	1160	14	operating	operating	NOUN
cusj-5580	1160	15	costs	cost	NOUN
cusj-5580	1160	16	to	to	PART
cusj-5580	1160	17	calculate	calculate	VERB
cusj-5580	1160	18	profitability	profitability	NOUN
cusj-5580	1160	19	of	of	ADP
cusj-5580	1160	20	the	the	DET
cusj-5580	1160	21	process	process	NOUN
cusj-5580	1160	22	,	,	PUNCT
cusj-5580	1160	23	considered	consider	VERB
cusj-5580	1160	24	the	the	DET
cusj-5580	1160	25	capital	capital	NOUN
cusj-5580	1160	26	cost	cost	NOUN
cusj-5580	1160	27	of	of	ADP
cusj-5580	1160	28	procuring	procure	VERB
cusj-5580	1160	29	and	and	CCONJ
cusj-5580	1160	30	maintaining	maintain	VERB
cusj-5580	1160	31	a	a	DET
cusj-5580	1160	32	manufacturing	manufacturing	NOUN
cusj-5580	1160	33	facility	facility	NOUN
cusj-5580	1160	34	and	and	CCONJ
cusj-5580	1160	35	the	the	DET
cusj-5580	1160	36	operating	operate	VERB
cusj-5580	1160	37	cost	cost	NOUN
cusj-5580	1160	38	of	of	ADP
cusj-5580	1160	39	the	the	DET
cusj-5580	1160	40	process	process	NOUN
cusj-5580	1160	41	based	base	VERB
cusj-5580	1160	42	on	on	ADP
cusj-5580	1160	43	our	our	PRON
cusj-5580	1160	44	production	production	NOUN
cusj-5580	1160	45	design	design	NOUN
cusj-5580	1160	46	basis	basis	NOUN
cusj-5580	1160	47	of	of	ADP
cusj-5580	1160	48	1150	1150	NUM
cusj-5580	1160	49	kg	kg	NOUN
cusj-5580	1160	50	of	of	ADP
cusj-5580	1160	51	nilotinib	nilotinib	NOUN
cusj-5580	1160	52	.	.	PUNCT
cusj-5580	1161	1	we	we	PRON
cusj-5580	1161	2	estimated	estimate	VERB
cusj-5580	1161	3	a	a	DET
cusj-5580	1161	4	small	small	ADJ
cusj-5580	1161	5	-	-	PUNCT
cusj-5580	1161	6	scale	scale	NOUN
cusj-5580	1161	7	manufacturing	manufacturing	NOUN
cusj-5580	1161	8	facility	facility	NOUN
cusj-5580	1161	9	will	will	AUX
cusj-5580	1161	10	cost	cost	VERB
cusj-5580	1161	11	~	~	PUNCT
cusj-5580	1161	12	$	$	SYM
cusj-5580	1161	13	2	2	NUM
cusj-5580	1161	14	million	million	NUM
cusj-5580	1161	15	usd	usd	NOUN
cusj-5580	1161	16	and	and	CCONJ
cusj-5580	1161	17	an	an	DET
cusj-5580	1161	18	additional	additional	ADJ
cusj-5580	1161	19	~$2	~$2	NUM
cusj-5580	1161	20	million	million	NUM
cusj-5580	1161	21	to	to	PART
cusj-5580	1161	22	have	have	VERB
cusj-5580	1161	23	the	the	DET
cusj-5580	1161	24	facility	facility	NOUN
cusj-5580	1161	25	cgmp	cgmp	PROPN
cusj-5580	1161	26	certified	certify	VERB
cusj-5580	1161	27	for	for	ADP
cusj-5580	1161	28	production	production	NOUN
cusj-5580	1161	29	.	.	PUNCT
cusj-5580	1162	1	direct	direct	ADJ
cusj-5580	1162	2	costs	cost	NOUN
cusj-5580	1162	3	associated	associate	VERB
cusj-5580	1162	4	with	with	ADP
cusj-5580	1162	5	production	production	NOUN
cusj-5580	1162	6	include	include	VERB
cusj-5580	1162	7	employee	employee	NOUN
cusj-5580	1162	8	cost	cost	NOUN
cusj-5580	1162	9	,	,	PUNCT
cusj-5580	1162	10	utility	utility	NOUN
cusj-5580	1162	11	cost	cost	NOUN
cusj-5580	1162	12	and	and	CCONJ
cusj-5580	1162	13	waste	waste	NOUN
cusj-5580	1162	14	management	management	NOUN
cusj-5580	1162	15	cost	cost	NOUN
cusj-5580	1162	16	.	.	PUNCT
cusj-5580	1163	1	we	we	PRON
cusj-5580	1163	2	evaluated	evaluate	VERB
cusj-5580	1163	3	our	our	PRON
cusj-5580	1163	4	employee	employee	NOUN
cusj-5580	1163	5	needs	need	NOUN
cusj-5580	1163	6	based	base	VERB
cusj-5580	1163	7	on	on	ADP
cusj-5580	1163	8	existing	exist	VERB
cusj-5580	1163	9	industry	industry	NOUN
cusj-5580	1163	10	data	datum	NOUN
cusj-5580	1163	11	.	.	PUNCT
cusj-5580	1164	1	based	base	VERB
cusj-5580	1164	2	on	on	ADP
cusj-5580	1164	3	estimations	estimation	NOUN
cusj-5580	1164	4	for	for	ADP
cusj-5580	1164	5	a	a	DET
cusj-5580	1164	6	small	small	ADJ
cusj-5580	1164	7	-	-	PUNCT
cusj-5580	1164	8	scale	scale	NOUN
cusj-5580	1164	9	production	production	NOUN
cusj-5580	1164	10	facility	facility	NOUN
cusj-5580	1164	11	and	and	CCONJ
cusj-5580	1164	12	accounting	accounting	NOUN
cusj-5580	1164	13	for	for	ADP
cusj-5580	1164	14	employee	employee	NOUN
cusj-5580	1164	15	benefits	benefit	NOUN
cusj-5580	1164	16	and	and	CCONJ
cusj-5580	1164	17	human	human	ADJ
cusj-5580	1164	18	resources	resource	NOUN
cusj-5580	1164	19	cost	cost	NOUN
cusj-5580	1164	20	,	,	PUNCT
cusj-5580	1164	21	our	our	PRON
cusj-5580	1164	22	estimation	estimation	NOUN
cusj-5580	1164	23	for	for	ADP
cusj-5580	1164	24	employee	employee	NOUN
cusj-5580	1164	25	cost	cost	NOUN
cusj-5580	1164	26	was	be	AUX
cusj-5580	1164	27	$	$	SYM
cusj-5580	1164	28	1,100,000$1,400,000	1,100,000$1,400,000	NUM
cusj-5580	1164	29	usd	usd	NOUN
cusj-5580	1164	30	per	per	ADP
cusj-5580	1164	31	year	year	NOUN
cusj-5580	1164	32	.	.	PUNCT
cusj-5580	1165	1	we	we	PRON
cusj-5580	1165	2	have	have	AUX
cusj-5580	1165	3	also	also	ADV
cusj-5580	1165	4	predicted	predict	VERB
cusj-5580	1165	5	a	a	DET
cusj-5580	1165	6	budget	budget	NOUN
cusj-5580	1165	7	of	of	ADP
cusj-5580	1165	8	$	$	SYM
cusj-5580	1165	9	50,000	50,000	NUM
cusj-5580	1165	10	for	for	ADP
cusj-5580	1165	11	the	the	DET
cusj-5580	1165	12	annual	annual	ADJ
cusj-5580	1165	13	maintenance	maintenance	NOUN
cusj-5580	1165	14	and	and	CCONJ
cusj-5580	1165	15	servicing	servicing	NOUN
cusj-5580	1165	16	of	of	ADP
cusj-5580	1165	17	the	the	DET
cusj-5580	1165	18	equipment	equipment	NOUN
cusj-5580	1165	19	.	.	PUNCT
cusj-5580	1166	1	to	to	PART
cusj-5580	1166	2	implement	implement	VERB
cusj-5580	1166	3	a	a	DET
cusj-5580	1166	4	system	system	NOUN
cusj-5580	1166	5	to	to	PART
cusj-5580	1166	6	dispose	dispose	VERB
cusj-5580	1166	7	of	of	ADP
cusj-5580	1166	8	the	the	DET
cusj-5580	1166	9	organic	organic	ADJ
cusj-5580	1166	10	waste	waste	NOUN
cusj-5580	1166	11	in	in	ADP
cusj-5580	1166	12	an	an	DET
cusj-5580	1166	13	environmentally	environmentally	ADV
cusj-5580	1166	14	friendly	friendly	ADJ
cusj-5580	1166	15	way	way	NOUN
cusj-5580	1166	16	in	in	ADP
cusj-5580	1166	17	accordance	accordance	NOUN
cusj-5580	1166	18	with	with	ADP
cusj-5580	1166	19	epa	epa	PROPN
cusj-5580	1166	20	and	and	CCONJ
cusj-5580	1166	21	osha	osha	PROPN
cusj-5580	1166	22	regulations	regulation	NOUN
cusj-5580	1166	23	,	,	PUNCT
cusj-5580	1166	24	we	we	PRON
cusj-5580	1166	25	estimate	estimate	VERB
cusj-5580	1166	26	the	the	DET
cusj-5580	1166	27	cost	cost	NOUN
cusj-5580	1166	28	of	of	ADP
cusj-5580	1166	29	a	a	DET
cusj-5580	1166	30	waste	waste	NOUN
cusj-5580	1166	31	management	management	NOUN
cusj-5580	1166	32	system	system	NOUN
cusj-5580	1166	33	for	for	ADP
cusj-5580	1166	34	our	our	PRON
cusj-5580	1166	35	design	design	NOUN
cusj-5580	1166	36	will	will	AUX
cusj-5580	1166	37	be	be	AUX
cusj-5580	1166	38	$	$	SYM
cusj-5580	1166	39	200,000	200,000	NUM
cusj-5580	1166	40	on	on	ADP
cusj-5580	1166	41	an	an	DET
cusj-5580	1166	42	annual	annual	ADJ
cusj-5580	1166	43	basis	basis	NOUN
cusj-5580	1166	44	.	.	PUNCT
cusj-5580	1167	1	based	base	VERB
cusj-5580	1167	2	on	on	ADP
cusj-5580	1167	3	our	our	PRON
cusj-5580	1167	4	energy	energy	NOUN
cusj-5580	1167	5	and	and	CCONJ
cusj-5580	1167	6	water	water	NOUN
cusj-5580	1167	7	needs	need	NOUN
cusj-5580	1167	8	,	,	PUNCT
cusj-5580	1167	9	we	we	PRON
cusj-5580	1167	10	will	will	AUX
cusj-5580	1167	11	require	require	VERB
cusj-5580	1167	12	a	a	DET
cusj-5580	1167	13	budget	budget	NOUN
cusj-5580	1167	14	of	of	ADP
cusj-5580	1167	15	$	$	SYM
cusj-5580	1167	16	500,000	500,000	NUM
cusj-5580	1167	17	for	for	ADP
cusj-5580	1167	18	yearly	yearly	ADJ
cusj-5580	1167	19	utility	utility	NOUN
cusj-5580	1167	20	cost	cost	NOUN
cusj-5580	1167	21	.	.	PUNCT
cusj-5580	1168	1	ii	ii	PROPN
cusj-5580	1168	2	.	.	PUNCT
cusj-5580	1169	1	reactor	reactor	NOUN
cusj-5580	1169	2	,	,	PUNCT
cusj-5580	1169	3	piping	piping	NOUN
cusj-5580	1169	4	,	,	PUNCT
cusj-5580	1169	5	and	and	CCONJ
cusj-5580	1169	6	distillation	distillation	NOUN
cusj-5580	1169	7	tower	tower	NOUN
cusj-5580	1169	8	costs	cost	VERB
cusj-5580	1169	9	the	the	DET
cusj-5580	1169	10	design	design	NOUN
cusj-5580	1169	11	of	of	ADP
cusj-5580	1169	12	the	the	DET
cusj-5580	1169	13	synthesis	synthesis	NOUN
cusj-5580	1169	14	process	process	NOUN
cusj-5580	1169	15	for	for	ADP
cusj-5580	1169	16	nilotinib	nilotinib	NOUN
cusj-5580	1169	17	will	will	AUX
cusj-5580	1169	18	require	require	VERB
cusj-5580	1169	19	properly	properly	ADV
cusj-5580	1169	20	sized	sized	ADJ
cusj-5580	1169	21	industrial	industrial	ADJ
cusj-5580	1169	22	reactors	reactor	NOUN
cusj-5580	1169	23	and	and	CCONJ
cusj-5580	1169	24	piping	piping	NOUN
cusj-5580	1169	25	.	.	PUNCT
cusj-5580	1170	1	the	the	DET
cusj-5580	1170	2	pbrs	pbrs	NOUN
cusj-5580	1170	3	must	must	AUX
cusj-5580	1170	4	be	be	AUX
cusj-5580	1170	5	capable	capable	ADJ
cusj-5580	1170	6	of	of	ADP
cusj-5580	1170	7	resisting	resist	VERB
cusj-5580	1170	8	the	the	DET
cusj-5580	1170	9	organic	organic	ADJ
cusj-5580	1170	10	solvents	solvent	NOUN
cusj-5580	1170	11	and	and	CCONJ
cusj-5580	1170	12	the	the	DET
cusj-5580	1170	13	catalysts	catalyst	NOUN
cusj-5580	1170	14	that	that	PRON
cusj-5580	1170	15	will	will	AUX
cusj-5580	1170	16	be	be	AUX
cusj-5580	1170	17	reacting	react	VERB
cusj-5580	1170	18	inside	inside	ADP
cusj-5580	1170	19	the	the	DET
cusj-5580	1170	20	vessels	vessel	NOUN
cusj-5580	1170	21	.	.	PUNCT
cusj-5580	1171	1	316l	316l	NUM
cusj-5580	1171	2	grade	grade	NOUN
cusj-5580	1171	3	steel	steel	NOUN
cusj-5580	1171	4	is	be	AUX
cusj-5580	1171	5	the	the	DET
cusj-5580	1171	6	pharmaceutical	pharmaceutical	ADJ
cusj-5580	1171	7	industry	industry	NOUN
cusj-5580	1171	8	standard	standard	NOUN
cusj-5580	1171	9	for	for	ADP
cusj-5580	1171	10	contact	contact	NOUN
cusj-5580	1171	11	with	with	ADP
cusj-5580	1171	12	drug	drug	NOUN
cusj-5580	1171	13	-	-	PUNCT
cusj-5580	1171	14	based	base	VERB
cusj-5580	1171	15	flow	flow	NOUN
cusj-5580	1171	16	to	to	PART
cusj-5580	1171	17	avoid	avoid	VERB
cusj-5580	1171	18	contamination	contamination	NOUN
cusj-5580	1171	19	.	.	PUNCT
cusj-5580	1172	1	the	the	DET
cusj-5580	1172	2	total	total	ADJ
cusj-5580	1172	3	cost	cost	NOUN
cusj-5580	1172	4	of	of	ADP
cusj-5580	1172	5	three	three	NUM
cusj-5580	1172	6	0.15	0.15	NUM
cusj-5580	1172	7	m3	m3	PROPN
cusj-5580	1172	8	316l	316l	PROPN
cusj-5580	1172	9	steel	steel	NOUN
cusj-5580	1172	10	pbrs	pbrs	NOUN
cusj-5580	1172	11	is	be	AUX
cusj-5580	1172	12	$	$	SYM
cusj-5580	1172	13	75,600	75,600	NUM
cusj-5580	1172	14	.	.	PUNCT
cusj-5580	1173	1	it	it	PRON
cusj-5580	1173	2	is	be	AUX
cusj-5580	1173	3	estimated	estimate	VERB
cusj-5580	1173	4	from	from	ADP
cusj-5580	1173	5	our	our	PRON
cusj-5580	1173	6	process	process	NOUN
cusj-5580	1173	7	flow	flow	NOUN
cusj-5580	1173	8	diagram	diagram	NOUN
cusj-5580	1173	9	that	that	SCONJ
cusj-5580	1173	10	at	at	ADV
cusj-5580	1173	11	least	least	ADV
cusj-5580	1173	12	300	300	NUM
cusj-5580	1173	13	feet	foot	NOUN
cusj-5580	1173	14	of	of	ADP
cusj-5580	1173	15	316l	316l	NUM
cusj-5580	1173	16	steel	steel	NOUN
cusj-5580	1173	17	piping	piping	NOUN
cusj-5580	1173	18	at	at	ADP
cusj-5580	1173	19	1	1	NUM
cusj-5580	1173	20	”	"	PUNCT
cusj-5580	1173	21	piping	piping	NOUN
cusj-5580	1173	22	size	size	NOUN
cusj-5580	1173	23	will	will	AUX
cusj-5580	1173	24	cost	cost	VERB
cusj-5580	1173	25	$	$	SYM
cusj-5580	1173	26	8,850	8,850	NUM
cusj-5580	1173	27	.	.	PUNCT
cusj-5580	1174	1	the	the	DET
cusj-5580	1174	2	thickness	thickness	NOUN
cusj-5580	1174	3	of	of	ADP
cusj-5580	1174	4	the	the	DET
cusj-5580	1174	5	piping	piping	NOUN
cusj-5580	1174	6	is	be	AUX
cusj-5580	1174	7	appropriate	appropriate	ADJ
cusj-5580	1174	8	for	for	ADP
cusj-5580	1174	9	the	the	DET
cusj-5580	1174	10	expected	expect	VERB
cusj-5580	1174	11	flow	flow	NOUN
cusj-5580	1174	12	rates	rate	NOUN
cusj-5580	1174	13	and	and	CCONJ
cusj-5580	1174	14	the	the	DET
cusj-5580	1174	15	pressure	pressure	NOUN
cusj-5580	1174	16	drops	drop	NOUN
cusj-5580	1174	17	expected	expect	VERB
cusj-5580	1174	18	from	from	ADP
cusj-5580	1174	19	the	the	DET
cusj-5580	1174	20	system	system	NOUN
cusj-5580	1174	21	and	and	CCONJ
cusj-5580	1174	22	confirmed	confirm	VERB
cusj-5580	1174	23	with	with	ADP
cusj-5580	1174	24	chemcad	chemcad	NOUN
cusj-5580	1174	25	.	.	PUNCT
cusj-5580	1175	1	the	the	DET
cusj-5580	1175	2	distillation	distillation	NOUN
cusj-5580	1175	3	towers	tower	NOUN
cusj-5580	1175	4	that	that	SCONJ
cusj-5580	1175	5	our	our	PRON
cusj-5580	1175	6	process	process	NOUN
cusj-5580	1175	7	will	will	AUX
cusj-5580	1175	8	require	require	VERB
cusj-5580	1175	9	for	for	SCONJ
cusj-5580	1175	10	the	the	DET
cusj-5580	1175	11	separation	separation	NOUN
cusj-5580	1175	12	and	and	CCONJ
cusj-5580	1175	13	purification	purification	NOUN
cusj-5580	1175	14	of	of	ADP
cusj-5580	1175	15	products	product	NOUN
cusj-5580	1175	16	are	be	AUX
cusj-5580	1175	17	expected	expect	VERB
cusj-5580	1175	18	to	to	PART
cusj-5580	1175	19	cost	cost	VERB
cusj-5580	1175	20	$	$	SYM
cusj-5580	1175	21	55,100	55,100	NUM
cusj-5580	1175	22	in	in	ADP
cusj-5580	1175	23	total	total	NOUN
cusj-5580	1175	24	.	.	PUNCT
cusj-5580	1176	1	thus	thus	ADV
cusj-5580	1176	2	,	,	PUNCT
cusj-5580	1176	3	the	the	DET
cusj-5580	1176	4	overall	overall	ADJ
cusj-5580	1176	5	equipment	equipment	NOUN
cusj-5580	1176	6	cost	cost	NOUN
cusj-5580	1176	7	is	be	AUX
cusj-5580	1176	8	estimated	estimate	VERB
cusj-5580	1176	9	to	to	PART
cusj-5580	1176	10	be	be	AUX
cusj-5580	1176	11	~	~	PUNCT
cusj-5580	1176	12	$	$	SYM
cusj-5580	1176	13	140,000	140,000	NUM
cusj-5580	1176	14	.	.	PUNCT
cusj-5580	1177	1	this	this	DET
cusj-5580	1177	2	relatively	relatively	ADV
cusj-5580	1177	3	low	low	ADJ
cusj-5580	1177	4	cost	cost	NOUN
cusj-5580	1177	5	is	be	AUX
cusj-5580	1177	6	achieved	achieve	VERB
cusj-5580	1177	7	through	through	ADP
cusj-5580	1177	8	the	the	DET
cusj-5580	1177	9	low	low	ADJ
cusj-5580	1177	10	process	process	NOUN
cusj-5580	1177	11	flow	flow	NOUN
cusj-5580	1177	12	rate	rate	NOUN
cusj-5580	1177	13	as	as	SCONJ
cusj-5580	1177	14	the	the	DET
cusj-5580	1177	15	active	active	ADJ
cusj-5580	1177	16	ingredient	ingredient	NOUN
cusj-5580	1177	17	will	will	AUX
cusj-5580	1177	18	be	be	AUX
cusj-5580	1177	19	produced	produce	VERB
cusj-5580	1177	20	in	in	ADP
cusj-5580	1177	21	small	small	ADJ
cusj-5580	1177	22	amounts	amount	NOUN
cusj-5580	1177	23	throughout	throughout	ADP
cusj-5580	1177	24	the	the	DET
cusj-5580	1177	25	year	year	NOUN
cusj-5580	1177	26	and	and	CCONJ
cusj-5580	1177	27	does	do	AUX
cusj-5580	1177	28	not	not	PART
cusj-5580	1177	29	require	require	VERB
cusj-5580	1177	30	enormous	enormous	ADJ
cusj-5580	1177	31	vessel	vessel	NOUN
cusj-5580	1177	32	capacities	capacity	NOUN
cusj-5580	1177	33	.	.	PUNCT
cusj-5580	1178	1	iii	iii	X
cusj-5580	1178	2	.	.	PUNCT
cusj-5580	1179	1	starting	start	VERB
cusj-5580	1179	2	reagent	reagent	ADJ
cusj-5580	1179	3	costs	cost	NOUN
cusj-5580	1179	4	we	we	PRON
cusj-5580	1179	5	have	have	AUX
cusj-5580	1179	6	also	also	ADV
cusj-5580	1179	7	calculated	calculate	VERB
cusj-5580	1179	8	the	the	DET
cusj-5580	1179	9	costs	cost	NOUN
cusj-5580	1179	10	of	of	ADP
cusj-5580	1179	11	purchasing	purchase	VERB
cusj-5580	1179	12	the	the	DET
cusj-5580	1179	13	four	four	NUM
cusj-5580	1179	14	starting	start	VERB
cusj-5580	1179	15	material	material	ADJ
cusj-5580	1179	16	components	component	NOUN
cusj-5580	1179	17	of	of	ADP
cusj-5580	1179	18	the	the	DET
cusj-5580	1179	19	buchwald	buchwald	ADJ
cusj-5580	1179	20	reaction	reaction	NOUN
cusj-5580	1179	21	as	as	SCONJ
cusj-5580	1179	22	shown	show	VERB
cusj-5580	1179	23	in	in	ADP
cusj-5580	1179	24	table	table	NOUN
cusj-5580	1179	25	4	4	NUM
cusj-5580	1179	26	.	.	PUNCT
cusj-5580	1180	1	the	the	DET
cusj-5580	1180	2	total	total	ADJ
cusj-5580	1180	3	molar	molar	ADJ
cusj-5580	1180	4	amount	amount	NOUN
cusj-5580	1180	5	and	and	CCONJ
cusj-5580	1180	6	subsequent	subsequent	ADJ
cusj-5580	1180	7	mass	mass	NOUN
cusj-5580	1180	8	of	of	ADP
cusj-5580	1180	9	each	each	DET
cusj-5580	1180	10	reactant	reactant	NOUN
cusj-5580	1180	11	required	require	VERB
cusj-5580	1180	12	was	be	AUX
cusj-5580	1180	13	calculated	calculate	VERB
cusj-5580	1180	14	based	base	VERB
cusj-5580	1180	15	on	on	ADP
cusj-5580	1180	16	the	the	DET
cusj-5580	1180	17	process	process	NOUN
cusj-5580	1180	18	production	production	NOUN
cusj-5580	1180	19	demands	demand	NOUN
cusj-5580	1180	20	.	.	PUNCT
cusj-5580	1181	1	the	the	DET
cusj-5580	1181	2	total	total	ADJ
cusj-5580	1181	3	estimated	estimate	VERB
cusj-5580	1181	4	annual	annual	ADJ
cusj-5580	1181	5	costs	cost	NOUN
cusj-5580	1181	6	of	of	ADP
cusj-5580	1181	7	purchasing	purchase	VERB
cusj-5580	1181	8	the	the	DET
cusj-5580	1181	9	starting	start	VERB
cusj-5580	1181	10	components	component	NOUN
cusj-5580	1181	11	of	of	ADP
cusj-5580	1181	12	the	the	DET
cusj-5580	1181	13	buchwald	buchwald	ADJ
cusj-5580	1181	14	synthesis	synthesis	NOUN
cusj-5580	1181	15	is	be	AUX
cusj-5580	1181	16	estimated	estimate	VERB
cusj-5580	1181	17	to	to	PART
cusj-5580	1181	18	be	be	AUX
cusj-5580	1181	19	around	around	ADP
cusj-5580	1181	20	$	$	SYM
cusj-5580	1181	21	5,500,000	5,500,000	NUM
cusj-5580	1181	22	.	.	PUNCT
cusj-5580	1181	23	table	table	NOUN
cusj-5580	1181	24	4	4	NUM
cusj-5580	1181	25	.	.	PUNCT
cusj-5580	1181	26	material	material	NOUN
cusj-5580	1181	27	economics	economic	NOUN
cusj-5580	1181	28	of	of	ADP
cusj-5580	1181	29	starting	start	VERB
cusj-5580	1181	30	material	material	NOUN
cusj-5580	1181	31	for	for	ADP
cusj-5580	1181	32	nilotinib	nilotinib	NOUN
cusj-5580	1181	33	production	production	NOUN
cusj-5580	1181	34	.	.	PUNCT
cusj-5580	1182	1	overall	overall	ADJ
cusj-5580	1182	2	costs	cost	NOUN
cusj-5580	1182	3	and	and	CCONJ
cusj-5580	1182	4	final	final	ADJ
cusj-5580	1182	5	profit	profit	NOUN
cusj-5580	1182	6	calculation	calculation	NOUN
cusj-5580	1182	7	for	for	ADP
cusj-5580	1182	8	the	the	DET
cusj-5580	1182	9	first	first	ADJ
cusj-5580	1182	10	year	year	NOUN
cusj-5580	1182	11	of	of	ADP
cusj-5580	1182	12	production	production	NOUN
cusj-5580	1182	13	,	,	PUNCT
cusj-5580	1182	14	the	the	DET
cusj-5580	1182	15	overall	overall	ADJ
cusj-5580	1182	16	process	process	NOUN
cusj-5580	1182	17	cost	cost	NOUN
cusj-5580	1182	18	will	will	AUX
cusj-5580	1182	19	be	be	AUX
cusj-5580	1182	20	near	near	ADP
cusj-5580	1182	21	$	$	SYM
cusj-5580	1182	22	12	12	NUM
cusj-5580	1182	23	million	million	NUM
cusj-5580	1182	24	,	,	PUNCT
cusj-5580	1182	25	after	after	ADP
cusj-5580	1182	26	which	which	PRON
cusj-5580	1182	27	the	the	DET
cusj-5580	1182	28	overall	overall	ADJ
cusj-5580	1182	29	costs	cost	NOUN
cusj-5580	1182	30	drop	drop	VERB
cusj-5580	1182	31	to	to	ADP
cusj-5580	1182	32	around	around	ADP
cusj-5580	1182	33	$	$	SYM
cusj-5580	1182	34	8	8	NUM
cusj-5580	1182	35	million	million	NUM
cusj-5580	1182	36	as	as	SCONJ
cusj-5580	1182	37	shown	show	VERB
cusj-5580	1182	38	in	in	ADP
cusj-5580	1182	39	table	table	NOUN
cusj-5580	1182	40	5	5	NUM
cusj-5580	1182	41	.	.	PUNCT
cusj-5580	1182	42	considering	consider	VERB
cusj-5580	1182	43	the	the	DET
cusj-5580	1182	44	annual	annual	ADJ
cusj-5580	1182	45	projections	projection	NOUN
cusj-5580	1182	46	of	of	ADP
cusj-5580	1182	47	a	a	DET
cusj-5580	1182	48	profit	profit	NOUN
cusj-5580	1182	49	of	of	ADP
cusj-5580	1182	50	$	$	SYM
cusj-5580	1182	51	276	276	NUM
cusj-5580	1182	52	million	million	NUM
cusj-5580	1182	53	dollars	dollar	NOUN
cusj-5580	1182	54	,	,	PUNCT
cusj-5580	1182	55	capital	capital	NOUN
cusj-5580	1182	56	and	and	CCONJ
cusj-5580	1182	57	operating	operate	VERB
cusj-5580	1182	58	expenditure	expenditure	NOUN
cusj-5580	1182	59	only	only	ADV
cusj-5580	1182	60	accounts	account	VERB
cusj-5580	1182	61	for	for	ADP
cusj-5580	1182	62	4.2	4.2	NUM
cusj-5580	1182	63	%	%	NOUN
cusj-5580	1182	64	and	and	CCONJ
cusj-5580	1182	65	2.8	2.8	NUM
cusj-5580	1182	66	%	%	NOUN
cusj-5580	1182	67	of	of	ADP
cusj-5580	1182	68	revenue	revenue	NOUN
cusj-5580	1182	69	in	in	ADP
cusj-5580	1182	70	the	the	DET
cusj-5580	1182	71	first	first	ADJ
cusj-5580	1182	72	and	and	CCONJ
cusj-5580	1182	73	_	_	PUNCT
cusj-5580	1183	1	_	_	PUNCT
cusj-5580	1184	1	_	_	PUNCT
cusj-5580	1185	1	_	_	PUNCT
cusj-5580	1186	1	_	_	PUNCT
cusj-5580	1187	1	_	_	PUNCT
cusj-5580	1188	1	_	_	PUNCT
cusj-5580	1189	1	_	_	PUNCT
cusj-5580	1190	1	_	_	PUNCT
cusj-5580	1191	1	_	_	PUNCT
cusj-5580	1192	1	_	_	PUNCT
cusj-5580	1193	1	_	_	PUNCT
cusj-5580	1194	1	_	_	PUNCT
cusj-5580	1195	1	_	_	PUNCT
cusj-5580	1196	1	_	_	PUNCT
cusj-5580	1197	1	_	_	PUNCT
cusj-5580	1198	1	_	_	PUNCT
cusj-5580	1199	1	_	_	PUNCT
cusj-5580	1200	1	_	_	PUNCT
cusj-5580	1201	1	_	_	PUNCT
cusj-5580	1202	1	_	_	PUNCT
cusj-5580	1203	1	_	_	PUNCT
cusj-5580	1204	1	_	_	PUNCT
cusj-5580	1205	1	_	_	PUNCT
cusj-5580	1206	1	_	_	PUNCT
cusj-5580	1207	1	_	_	PUNCT
cusj-5580	1208	1	_	_	PUNCT
cusj-5580	1209	1	_	_	PUNCT
cusj-5580	1210	1	_	_	PUNCT
cusj-5580	1211	1	_	_	PUNCT
cusj-5580	1212	1	_	_	PUNCT
cusj-5580	1213	1	_	_	PUNCT
cusj-5580	1214	1	_	_	PUNCT
cusj-5580	1215	1	_	_	PUNCT
cusj-5580	1216	1	_	_	PUNCT
cusj-5580	1217	1	_	_	PUNCT
cusj-5580	1218	1	_	_	PUNCT
cusj-5580	1219	1	_	_	PUNCT
cusj-5580	1220	1	_	_	PUNCT
cusj-5580	1221	1	_	_	PUNCT
cusj-5580	1222	1	_	_	PUNCT
cusj-5580	1223	1	_	_	PUNCT
cusj-5580	1224	1	_	_	PUNCT
cusj-5580	1225	1	_	_	PUNCT
cusj-5580	1226	1	_	_	PUNCT
cusj-5580	1227	1	_	_	PUNCT
cusj-5580	1228	1	_	_	PUNCT
cusj-5580	1229	1	_	_	PUNCT
cusj-5580	1230	1	_	_	PUNCT
cusj-5580	1231	1	_	_	PUNCT
cusj-5580	1232	1	_	_	PUNCT
cusj-5580	1233	1	_	_	PUNCT
cusj-5580	1234	1	_	_	PUNCT
cusj-5580	1235	1	_	_	PUNCT
cusj-5580	1236	1	_	_	PUNCT
cusj-5580	1237	1	_	_	PUNCT
cusj-5580	1238	1	_	_	PUNCT
cusj-5580	1239	1	_	_	PUNCT
cusj-5580	1240	1	_	_	PUNCT
cusj-5580	1241	1	_	_	PUNCT
cusj-5580	1242	1	_	_	PUNCT
cusj-5580	1243	1	_	_	PUNCT
cusj-5580	1244	1	_	_	PUNCT
cusj-5580	1245	1	_	_	PUNCT
cusj-5580	1246	1	_	_	PUNCT
cusj-5580	1247	1	_	_	PUNCT
cusj-5580	1248	1	_	_	PUNCT
cusj-5580	1249	1	_	_	PUNCT
cusj-5580	1250	1	_	_	PUNCT
cusj-5580	1251	1	_	_	PUNCT
cusj-5580	1252	1	_	_	PUNCT
cusj-5580	1253	1	_	_	PUNCT
cusj-5580	1254	1	_	_	PUNCT
cusj-5580	1255	1	_	_	PUNCT
cusj-5580	1256	1	_	_	PUNCT
cusj-5580	1257	1	_	_	PUNCT
cusj-5580	1258	1	_	_	PUNCT
cusj-5580	1259	1	_	_	PUNCT
cusj-5580	1260	1	_	_	PUNCT
cusj-5580	1261	1	_	_	PUNCT
cusj-5580	1261	2	cusj	cusj	VERB
cusj-5580	1261	3	2019	2019	NUM
cusj-5580	1261	4	_	_	PUNCT
cusj-5580	1262	1	_	_	PUNCT
cusj-5580	1263	1	_	_	PUNCT
cusj-5580	1264	1	_	_	PUNCT
cusj-5580	1265	1	_	_	PUNCT
cusj-5580	1266	1	_	_	PUNCT
cusj-5580	1267	1	_	_	PUNCT
cusj-5580	1268	1	_	_	PUNCT
cusj-5580	1269	1	_	_	PUNCT
cusj-5580	1270	1	_	_	PUNCT
cusj-5580	1271	1	_	_	PUNCT
cusj-5580	1272	1	_	_	PUNCT
cusj-5580	1273	1	_	_	PUNCT
cusj-5580	1274	1	_	_	PUNCT
cusj-5580	1275	1	_	_	PUNCT
cusj-5580	1276	1	_	_	PUNCT
cusj-5580	1277	1	_	_	PUNCT
cusj-5580	1278	1	_	_	PUNCT
cusj-5580	1279	1	_	_	PUNCT
cusj-5580	1280	1	_	_	PUNCT
cusj-5580	1281	1	_	_	PUNCT
cusj-5580	1282	1	_	_	PUNCT
cusj-5580	1283	1	_	_	PUNCT
cusj-5580	1284	1	_	_	PUNCT
cusj-5580	1285	1	_	_	PUNCT
cusj-5580	1286	1	_	_	PUNCT
cusj-5580	1287	1	_	_	PUNCT
cusj-5580	1288	1	_	_	PUNCT
cusj-5580	1289	1	_	_	PUNCT
cusj-5580	1290	1	_	_	PUNCT
cusj-5580	1291	1	_	_	PUNCT
cusj-5580	1292	1	_	_	PUNCT
cusj-5580	1293	1	_	_	PUNCT
cusj-5580	1294	1	_	_	PUNCT
cusj-5580	1295	1	_	_	PUNCT
cusj-5580	1296	1	_	_	PUNCT
cusj-5580	1297	1	_	_	PUNCT
cusj-5580	1298	1	_	_	PUNCT
cusj-5580	1299	1	_	_	PUNCT
cusj-5580	1300	1	_	_	PUNCT
cusj-5580	1301	1	_	_	PUNCT
cusj-5580	1302	1	_	_	PUNCT
cusj-5580	1303	1	_	_	PUNCT
cusj-5580	1304	1	_	_	PUNCT
cusj-5580	1305	1	_	_	PUNCT
cusj-5580	1306	1	_	_	PUNCT
cusj-5580	1307	1	_	_	PUNCT
cusj-5580	1308	1	_	_	PUNCT
cusj-5580	1309	1	_	_	PUNCT
cusj-5580	1310	1	_	_	PUNCT
cusj-5580	1311	1	_	_	PUNCT
cusj-5580	1312	1	_	_	PUNCT
cusj-5580	1313	1	_	_	PUNCT
cusj-5580	1314	1	_	_	PUNCT
cusj-5580	1315	1	_	_	PUNCT
cusj-5580	1316	1	_	_	PUNCT
cusj-5580	1317	1	_	_	PUNCT
cusj-5580	1318	1	_	_	PUNCT
cusj-5580	1319	1	_	_	PUNCT
cusj-5580	1320	1	_	_	PUNCT
cusj-5580	1321	1	_	_	PUNCT
cusj-5580	1322	1	_	_	PUNCT
cusj-5580	1323	1	_	_	PUNCT
cusj-5580	1324	1	_	_	PUNCT
cusj-5580	1325	1	_	_	PUNCT
cusj-5580	1326	1	_	_	PUNCT
cusj-5580	1327	1	_	_	PUNCT
cusj-5580	1328	1	_	_	PUNCT
cusj-5580	1329	1	_	_	PUNCT
cusj-5580	1330	1	_	_	PUNCT
cusj-5580	1331	1	_	_	PUNCT
cusj-5580	1332	1	_	_	PUNCT
cusj-5580	1333	1	_	_	PUNCT
cusj-5580	1334	1	_	_	PUNCT
cusj-5580	1335	1	_	_	PUNCT
cusj-5580	1336	1	_	_	PUNCT
cusj-5580	1337	1	_	_	PUNCT
cusj-5580	1338	1	_	_	PUNCT
cusj-5580	1339	1	_	_	PUNCT
cusj-5580	1340	1	_	_	PUNCT
cusj-5580	1341	1	_	_	PUNCT
cusj-5580	1342	1	_	_	PUNCT
cusj-5580	1343	1	_	_	PUNCT
cusj-5580	1344	1	_	_	PUNCT
cusj-5580	1345	1	_	_	PUNCT
cusj-5580	1346	1	_	_	PUNCT
cusj-5580	1347	1	_	_	PUNCT
cusj-5580	1348	1	_	_	PUNCT
cusj-5580	1349	1	_	_	PUNCT
cusj-5580	1350	1	_	_	PUNCT
cusj-5580	1351	1	27	27	NUM
cusj-5580	1351	2	second	second	ADJ
cusj-5580	1351	3	year	year	NOUN
cusj-5580	1351	4	,	,	PUNCT
cusj-5580	1351	5	respectively	respectively	ADV
cusj-5580	1351	6	.	.	PUNCT
cusj-5580	1352	1	altogether	altogether	ADV
cusj-5580	1352	2	,	,	PUNCT
cusj-5580	1352	3	in	in	ADP
cusj-5580	1352	4	balancing	balance	VERB
cusj-5580	1352	5	our	our	PRON
cusj-5580	1352	6	predicted	predict	VERB
cusj-5580	1352	7	revenue	revenue	NOUN
cusj-5580	1352	8	with	with	ADP
cusj-5580	1352	9	predicted	predict	VERB
cusj-5580	1352	10	capital	capital	NOUN
cusj-5580	1352	11	/	/	SYM
cusj-5580	1352	12	operating	operate	VERB
cusj-5580	1352	13	expenditures	expenditure	NOUN
cusj-5580	1352	14	,	,	PUNCT
cusj-5580	1352	15	yearly	yearly	ADJ
cusj-5580	1352	16	profits	profit	NOUN
cusj-5580	1352	17	greater	great	ADJ
cusj-5580	1352	18	than	than	ADP
cusj-5580	1352	19	$	$	SYM
cusj-5580	1352	20	250	250	NUM
cusj-5580	1352	21	million	million	NUM
cusj-5580	1352	22	are	be	AUX
cusj-5580	1352	23	expected	expect	VERB
cusj-5580	1352	24	if	if	SCONJ
cusj-5580	1352	25	the	the	DET
cusj-5580	1352	26	design	design	NOUN
cusj-5580	1352	27	basis	basis	NOUN
cusj-5580	1352	28	criteria	criterion	NOUN
cusj-5580	1352	29	are	be	AUX
cusj-5580	1352	30	met	meet	VERB
cusj-5580	1352	31	and	and	CCONJ
cusj-5580	1352	32	15	15	NUM
cusj-5580	1352	33	%	%	NOUN
cusj-5580	1352	34	of	of	ADP
cusj-5580	1352	35	the	the	DET
cusj-5580	1352	36	nilotinib	nilotinib	NOUN
cusj-5580	1352	37	market	market	NOUN
cusj-5580	1352	38	share	share	NOUN
cusj-5580	1352	39	can	can	AUX
cusj-5580	1352	40	be	be	AUX
cusj-5580	1352	41	captured	capture	VERB
cusj-5580	1352	42	.	.	PUNCT
cusj-5580	1353	1	table	table	NOUN
cusj-5580	1353	2	5	5	NUM
cusj-5580	1353	3	.	.	PUNCT
cusj-5580	1353	4	table	table	NOUN
cusj-5580	1353	5	of	of	ADP
cusj-5580	1353	6	capital	capital	NOUN
cusj-5580	1353	7	and	and	CCONJ
cusj-5580	1353	8	operating	operating	NOUN
cusj-5580	1353	9	costs	cost	NOUN
cusj-5580	1353	10	.	.	PUNCT
cusj-5580	1354	1	iv	iv	X
cusj-5580	1354	2	.	.	PUNCT
cusj-5580	1354	3	conclusions	conclusion	NOUN
cusj-5580	1354	4	in	in	ADP
cusj-5580	1354	5	this	this	DET
cusj-5580	1354	6	investigation	investigation	NOUN
cusj-5580	1354	7	,	,	PUNCT
cusj-5580	1354	8	we	we	PRON
cusj-5580	1354	9	have	have	AUX
cusj-5580	1354	10	described	describe	VERB
cusj-5580	1354	11	a	a	DET
cusj-5580	1354	12	new	new	ADJ
cusj-5580	1354	13	method	method	NOUN
cusj-5580	1354	14	for	for	ADP
cusj-5580	1354	15	the	the	DET
cusj-5580	1354	16	large	large	ADJ
cusj-5580	1354	17	scale	scale	NOUN
cusj-5580	1354	18	production	production	NOUN
cusj-5580	1354	19	of	of	ADP
cusj-5580	1354	20	nilotinib	nilotinib	NOUN
cusj-5580	1354	21	,	,	PUNCT
cusj-5580	1354	22	an	an	DET
cusj-5580	1354	23	important	important	ADJ
cusj-5580	1354	24	chemotherapy	chemotherapy	NOUN
cusj-5580	1354	25	drug	drug	NOUN
cusj-5580	1354	26	.	.	PUNCT
cusj-5580	1355	1	current	current	ADJ
cusj-5580	1355	2	novartis	novartis	NOUN
cusj-5580	1355	3	practices	practice	NOUN
cusj-5580	1355	4	of	of	ADP
cusj-5580	1355	5	nilotinib	nilotinib	NOUN
cusj-5580	1355	6	synthesis	synthesis	NOUN
cusj-5580	1355	7	require	require	VERB
cusj-5580	1355	8	upwards	upwards	ADV
cusj-5580	1355	9	of	of	ADP
cusj-5580	1355	10	8	8	NUM
cusj-5580	1355	11	steps	step	NOUN
cusj-5580	1355	12	and	and	CCONJ
cusj-5580	1355	13	97	97	NUM
cusj-5580	1355	14	hours	hour	NOUN
cusj-5580	1355	15	of	of	ADP
cusj-5580	1355	16	reaction	reaction	NOUN
cusj-5580	1355	17	time	time	NOUN
cusj-5580	1355	18	.	.	PUNCT
cusj-5580	1356	1	by	by	ADP
cusj-5580	1356	2	contrast	contrast	NOUN
cusj-5580	1356	3	,	,	PUNCT
cusj-5580	1356	4	a	a	DET
cusj-5580	1356	5	recently	recently	ADV
cusj-5580	1356	6	developed	develop	VERB
cusj-5580	1356	7	approach	approach	NOUN
cusj-5580	1356	8	by	by	ADP
cusj-5580	1356	9	buchwald	buchwald	NOUN
cusj-5580	1356	10	and	and	CCONJ
cusj-5580	1356	11	coworkers	coworker	NOUN
cusj-5580	1356	12	allows	allow	VERB
cusj-5580	1356	13	for	for	ADP
cusj-5580	1356	14	the	the	DET
cusj-5580	1356	15	synthesis	synthesis	NOUN
cusj-5580	1356	16	of	of	ADP
cusj-5580	1356	17	nilotinib	nilotinib	NOUN
cusj-5580	1356	18	in	in	ADP
cusj-5580	1356	19	3	3	NUM
cusj-5580	1356	20	steps	step	NOUN
cusj-5580	1356	21	and	and	CCONJ
cusj-5580	1356	22	24	24	NUM
cusj-5580	1356	23	hours	hour	NOUN
cusj-5580	1356	24	.	.	PUNCT
cusj-5580	1357	1	until	until	ADP
cusj-5580	1357	2	now	now	ADV
cusj-5580	1357	3	,	,	PUNCT
cusj-5580	1357	4	this	this	DET
cusj-5580	1357	5	approach	approach	NOUN
cusj-5580	1357	6	had	have	AUX
cusj-5580	1357	7	only	only	ADV
cusj-5580	1357	8	been	be	AUX
cusj-5580	1357	9	designed	design	VERB
cusj-5580	1357	10	for	for	ADP
cusj-5580	1357	11	small	small	ADJ
cusj-5580	1357	12	scale	scale	NOUN
cusj-5580	1357	13	(	(	PUNCT
cusj-5580	1357	14	<	<	X
cusj-5580	1357	15	1	1	NUM
cusj-5580	1357	16	g	g	NOUN
cusj-5580	1357	17	)	)	PUNCT
cusj-5580	1357	18	synthesis	synthesis	NOUN
cusj-5580	1357	19	of	of	ADP
cusj-5580	1357	20	nilotinib	nilotinib	NOUN
cusj-5580	1357	21	in	in	ADP
cusj-5580	1357	22	laboratory	laboratory	NOUN
cusj-5580	1357	23	settings	setting	NOUN
cusj-5580	1357	24	.	.	PUNCT
cusj-5580	1358	1	this	this	DET
cusj-5580	1358	2	investigation	investigation	NOUN
cusj-5580	1358	3	provides	provide	VERB
cusj-5580	1358	4	a	a	DET
cusj-5580	1358	5	framework	framework	NOUN
cusj-5580	1358	6	for	for	ADP
cusj-5580	1358	7	which	which	PRON
cusj-5580	1358	8	the	the	DET
cusj-5580	1358	9	buchwald	buchwald	ADJ
cusj-5580	1358	10	synthesis	synthesis	NOUN
cusj-5580	1358	11	of	of	ADP
cusj-5580	1358	12	nilotinib	nilotinib	NOUN
cusj-5580	1358	13	can	can	AUX
cusj-5580	1358	14	be	be	AUX
cusj-5580	1358	15	scaled	scale	VERB
cusj-5580	1358	16	up	up	ADP
cusj-5580	1358	17	to	to	PART
cusj-5580	1358	18	produce	produce	VERB
cusj-5580	1358	19	1150	1150	NUM
cusj-5580	1358	20	kg	kg	NOUN
cusj-5580	1358	21	per	per	ADP
cusj-5580	1358	22	year	year	NOUN
cusj-5580	1358	23	much	much	ADV
cusj-5580	1358	24	more	more	ADV
cusj-5580	1358	25	efficiently	efficiently	ADV
cusj-5580	1358	26	than	than	ADP
cusj-5580	1358	27	novartis	novartis	NOUN
cusj-5580	1358	28	’s	’s	PART
cusj-5580	1358	29	current	current	ADJ
cusj-5580	1358	30	methods	method	NOUN
cusj-5580	1358	31	.	.	PUNCT
cusj-5580	1359	1	we	we	PRON
cusj-5580	1359	2	adopted	adopt	VERB
cusj-5580	1359	3	the	the	DET
cusj-5580	1359	4	role	role	NOUN
cusj-5580	1359	5	of	of	ADP
cusj-5580	1359	6	a	a	DET
cusj-5580	1359	7	generic	generic	ADJ
cusj-5580	1359	8	pharmaceutical	pharmaceutical	ADJ
cusj-5580	1359	9	company	company	NOUN
cusj-5580	1359	10	seeking	seek	VERB
cusj-5580	1359	11	to	to	PART
cusj-5580	1359	12	produce	produce	VERB
cusj-5580	1359	13	nilotinib	nilotinib	NOUN
cusj-5580	1359	14	upon	upon	SCONJ
cusj-5580	1359	15	novartis	novartis	PROPN
cusj-5580	1359	16	’s	’s	PART
cusj-5580	1359	17	patent	patent	NOUN
cusj-5580	1359	18	expiration	expiration	NOUN
cusj-5580	1359	19	in	in	ADP
cusj-5580	1359	20	2023	2023	NUM
cusj-5580	1359	21	.	.	PUNCT
cusj-5580	1360	1	our	our	PRON
cusj-5580	1360	2	goal	goal	NOUN
cusj-5580	1360	3	of	of	ADP
cusj-5580	1360	4	capturing	capture	VERB
cusj-5580	1360	5	15	15	NUM
cusj-5580	1360	6	%	%	NOUN
cusj-5580	1360	7	of	of	ADP
cusj-5580	1360	8	nilotinib	nilotinib	NOUN
cusj-5580	1360	9	’s	’s	PART
cusj-5580	1360	10	market	market	NOUN
cusj-5580	1360	11	share	share	NOUN
cusj-5580	1360	12	allowed	allow	VERB
cusj-5580	1360	13	us	we	PRON
cusj-5580	1360	14	to	to	PART
cusj-5580	1360	15	calculate	calculate	VERB
cusj-5580	1360	16	our	our	PRON
cusj-5580	1360	17	needed	need	VERB
cusj-5580	1360	18	production	production	NOUN
cusj-5580	1360	19	to	to	PART
cusj-5580	1360	20	be	be	AUX
cusj-5580	1360	21	1150	1150	NUM
cusj-5580	1360	22	kg	kg	NOUN
cusj-5580	1360	23	/	/	SYM
cusj-5580	1360	24	year	year	NOUN
cusj-5580	1360	25	with	with	ADP
cusj-5580	1360	26	projected	project	VERB
cusj-5580	1360	27	revenue	revenue	NOUN
cusj-5580	1360	28	of	of	ADP
cusj-5580	1360	29	$	$	SYM
cusj-5580	1360	30	276	276	NUM
cusj-5580	1360	31	million	million	NUM
cusj-5580	1360	32	/	/	SYM
cusj-5580	1360	33	year	year	NOUN
cusj-5580	1360	34	(	(	PUNCT
cusj-5580	1360	35	assuming	assume	VERB
cusj-5580	1360	36	60	60	NUM
cusj-5580	1360	37	%	%	NOUN
cusj-5580	1360	38	price	price	NOUN
cusj-5580	1360	39	drop	drop	NOUN
cusj-5580	1360	40	in	in	ADP
cusj-5580	1360	41	generic	generic	ADJ
cusj-5580	1360	42	drugs	drug	NOUN
cusj-5580	1360	43	)	)	PUNCT
cusj-5580	1360	44	.	.	PUNCT
cusj-5580	1361	1	using	use	VERB
cusj-5580	1361	2	chemcad	chemcad	NOUN
cusj-5580	1361	3	software	software	NOUN
cusj-5580	1361	4	,	,	PUNCT
cusj-5580	1361	5	a	a	DET
cusj-5580	1361	6	new	new	ADJ
cusj-5580	1361	7	process	process	NOUN
cusj-5580	1361	8	flow	flow	NOUN
cusj-5580	1361	9	diagram	diagram	NOUN
cusj-5580	1361	10	was	be	AUX
cusj-5580	1361	11	constructed	construct	VERB
cusj-5580	1361	12	for	for	ADP
cusj-5580	1361	13	the	the	DET
cusj-5580	1361	14	scaled	scale	VERB
cusj-5580	1361	15	production	production	NOUN
cusj-5580	1361	16	of	of	ADP
cusj-5580	1361	17	nilotinib	nilotinib	NOUN
cusj-5580	1361	18	using	use	VERB
cusj-5580	1361	19	the	the	DET
cusj-5580	1361	20	buchwald	buchwald	ADJ
cusj-5580	1361	21	synthesis	synthesis	NOUN
cusj-5580	1361	22	.	.	PUNCT
cusj-5580	1362	1	our	our	PRON
cusj-5580	1362	2	approach	approach	NOUN
cusj-5580	1362	3	focused	focus	VERB
cusj-5580	1362	4	on	on	ADP
cusj-5580	1362	5	the	the	DET
cusj-5580	1362	6	use	use	NOUN
cusj-5580	1362	7	of	of	ADP
cusj-5580	1362	8	plug	plug	NOUN
cusj-5580	1362	9	flow	flow	NOUN
cusj-5580	1362	10	reactors	reactor	NOUN
cusj-5580	1362	11	in	in	ADP
cusj-5580	1362	12	order	order	NOUN
cusj-5580	1362	13	to	to	PART
cusj-5580	1362	14	achieve	achieve	VERB
cusj-5580	1362	15	a	a	DET
cusj-5580	1362	16	flow	flow	NOUN
cusj-5580	1362	17	-	-	PUNCT
cusj-5580	1362	18	based	base	VERB
cusj-5580	1362	19	synthesis	synthesis	NOUN
cusj-5580	1362	20	and	and	CCONJ
cusj-5580	1362	21	improve	improve	VERB
cusj-5580	1362	22	the	the	DET
cusj-5580	1362	23	overall	overall	ADJ
cusj-5580	1362	24	efficiency	efficiency	NOUN
cusj-5580	1362	25	and	and	CCONJ
cusj-5580	1362	26	safety	safety	NOUN
cusj-5580	1362	27	of	of	ADP
cusj-5580	1362	28	nilotinib	nilotinib	NOUN
cusj-5580	1362	29	production	production	NOUN
cusj-5580	1362	30	,	,	PUNCT
cusj-5580	1362	31	minimizing	minimize	VERB
cusj-5580	1362	32	the	the	DET
cusj-5580	1362	33	need	need	NOUN
cusj-5580	1362	34	for	for	ADP
cusj-5580	1362	35	solvent	solvent	NOUN
cusj-5580	1362	36	switching	switching	NOUN
cusj-5580	1362	37	or	or	CCONJ
cusj-5580	1362	38	complex	complex	ADJ
cusj-5580	1362	39	unit	unit	NOUN
cusj-5580	1362	40	operations	operation	NOUN
cusj-5580	1362	41	for	for	ADP
cusj-5580	1362	42	mass	mass	NOUN
cusj-5580	1362	43	transfers	transfer	NOUN
cusj-5580	1362	44	.	.	PUNCT
cusj-5580	1363	1	our	our	PRON
cusj-5580	1363	2	chemcad	chemcad	NOUN
cusj-5580	1363	3	program	program	NOUN
cusj-5580	1363	4	successfully	successfully	ADV
cusj-5580	1363	5	converged	converged	ADJ
cusj-5580	1363	6	and	and	CCONJ
cusj-5580	1363	7	mass	mass	NOUN
cusj-5580	1363	8	and	and	CCONJ
cusj-5580	1363	9	energy	energy	NOUN
cusj-5580	1363	10	balances	balance	NOUN
cusj-5580	1363	11	across	across	ADP
cusj-5580	1363	12	the	the	DET
cusj-5580	1363	13	system	system	NOUN
cusj-5580	1363	14	were	be	AUX
cusj-5580	1363	15	achieved	achieve	VERB
cusj-5580	1363	16	.	.	PUNCT
cusj-5580	1364	1	this	this	PRON
cusj-5580	1364	2	serves	serve	VERB
cusj-5580	1364	3	to	to	PART
cusj-5580	1364	4	demonstrate	demonstrate	VERB
cusj-5580	1364	5	that	that	SCONJ
cusj-5580	1364	6	it	it	PRON
cusj-5580	1364	7	is	be	AUX
cusj-5580	1364	8	possible	possible	ADJ
cusj-5580	1364	9	to	to	ADP
cusj-5580	1364	10	industrial	industrial	ADJ
cusj-5580	1364	11	scale	scale	NOUN
cusj-5580	1364	12	the	the	DET
cusj-5580	1364	13	buchwald	buchwald	ADJ
cusj-5580	1364	14	synthesis	synthesis	NOUN
cusj-5580	1364	15	while	while	SCONJ
cusj-5580	1364	16	maintaining	maintain	VERB
cusj-5580	1364	17	profitability	profitability	NOUN
cusj-5580	1364	18	.	.	PUNCT
cusj-5580	1365	1	this	this	PRON
cusj-5580	1365	2	we	we	PRON
cusj-5580	1365	3	hope	hope	VERB
cusj-5580	1365	4	serves	serve	VERB
cusj-5580	1365	5	to	to	PART
cusj-5580	1365	6	establish	establish	VERB
cusj-5580	1365	7	an	an	DET
cusj-5580	1365	8	initial	initial	ADJ
cusj-5580	1365	9	framework	framework	NOUN
cusj-5580	1365	10	by	by	ADP
cusj-5580	1365	11	which	which	PRON
cusj-5580	1365	12	the	the	DET
cusj-5580	1365	13	generic	generic	ADJ
cusj-5580	1365	14	form	form	NOUN
cusj-5580	1365	15	of	of	ADP
cusj-5580	1365	16	a	a	DET
cusj-5580	1365	17	life	life	NOUN
cusj-5580	1365	18	saving	save	VERB
cusj-5580	1365	19	medication	medication	NOUN
cusj-5580	1365	20	can	can	AUX
cusj-5580	1365	21	be	be	AUX
cusj-5580	1365	22	produced	produce	VERB
cusj-5580	1365	23	safely	safely	ADV
cusj-5580	1365	24	and	and	CCONJ
cusj-5580	1365	25	efficiently	efficiently	ADV
cusj-5580	1365	26	.	.	PUNCT
cusj-5580	1366	1	acronyms	acronyms	PROPN
cusj-5580	1366	2	asme	asme	PROPN
cusj-5580	1366	3	–	–	PUNCT
cusj-5580	1366	4	american	american	ADJ
cusj-5580	1366	5	society	society	NOUN
cusj-5580	1366	6	of	of	ADP
cusj-5580	1366	7	mechanical	mechanical	ADJ
cusj-5580	1366	8	engineers	engineer	NOUN
cusj-5580	1366	9	cad	cad	PROPN
cusj-5580	1366	10	–	–	PUNCT
cusj-5580	1366	11	computer	computer	NOUN
cusj-5580	1366	12	-	-	PUNCT
cusj-5580	1366	13	aided	aid	VERB
cusj-5580	1366	14	design	design	NOUN
cusj-5580	1366	15	�	�	PROPN
cusj-5580	1366	16	cml	cml	PROPN
cusj-5580	1366	17	–	–	PUNCT
cusj-5580	1366	18	chronic	chronic	ADJ
cusj-5580	1366	19	myelogenous	myelogenous	ADJ
cusj-5580	1366	20	leukemia	leukemia	NOUN
cusj-5580	1366	21	cgmp	cgmp	NOUN
cusj-5580	1366	22	–	–	PUNCT
cusj-5580	1366	23	current	current	ADJ
cusj-5580	1366	24	good	good	ADJ
cusj-5580	1366	25	manufacturing	manufacturing	NOUN
cusj-5580	1366	26	practices	practice	NOUN
cusj-5580	1366	27	epa	epa	PROPN
cusj-5580	1366	28	–	–	PUNCT
cusj-5580	1366	29	environmental	environmental	PROPN
cusj-5580	1366	30	protection	protection	PROPN
cusj-5580	1366	31	agency	agency	PROPN
cusj-5580	1366	32	fda	fda	PROPN
cusj-5580	1366	33	–	–	PUNCT
cusj-5580	1366	34	food	food	NOUN
cusj-5580	1366	35	and	and	CCONJ
cusj-5580	1366	36	drug	drug	PROPN
cusj-5580	1366	37	administration	administration	PROPN
cusj-5580	1366	38	hazop	hazop	PROPN
cusj-5580	1366	39	–	–	PUNCT
cusj-5580	1366	40	hazards	hazard	NOUN
cusj-5580	1366	41	and	and	CCONJ
cusj-5580	1366	42	operability	operability	NOUN
cusj-5580	1366	43	nci	nci	PROPN
cusj-5580	1366	44	–	–	PUNCT
cusj-5580	1366	45	national	national	PROPN
cusj-5580	1366	46	cancer	cancer	PROPN
cusj-5580	1366	47	institute	institute	PROPN
cusj-5580	1366	48	osha	osha	PROPN
cusj-5580	1366	49	–	–	PUNCT
cusj-5580	1366	50	occupational	occupational	ADJ
cusj-5580	1366	51	safety	safety	NOUN
cusj-5580	1366	52	and	and	CCONJ
cusj-5580	1366	53	health	health	PROPN
cusj-5580	1366	54	administration	administration	PROPN
cusj-5580	1366	55	pbr	pbr	PROPN
cusj-5580	1366	56	–	–	PUNCT
cusj-5580	1366	57	packed	pack	VERB
cusj-5580	1366	58	bed	bed	NOUN
cusj-5580	1366	59	reactor	reactor	NOUN
cusj-5580	1366	60	tki	tki	NOUN
cusj-5580	1366	61	–	–	PUNCT
cusj-5580	1366	62	tyrosine	tyrosine	NOUN
cusj-5580	1366	63	kinase	kinase	PROPN
cusj-5580	1366	64	inhibitor	inhibitor	PROPN
cusj-5580	1366	65	author	author	NOUN
cusj-5580	1366	66	information	information	NOUN
cusj-5580	1366	67	corresponding	correspond	VERB
cusj-5580	1366	68	author	author	NOUN
cusj-5580	1366	69	*	*	PUNCT
cusj-5580	1366	70	justin.cheung@stonybrookmedicine.edu	justin.cheung@stonybrookmedicine.edu	X
cusj-5580	1366	71	author	author	NOUN
cusj-5580	1366	72	contributions	contribution	NOUN
cusj-5580	1366	73	all	all	DET
cusj-5580	1366	74	authors	author	NOUN
cusj-5580	1366	75	contributed	contribute	VERB
cusj-5580	1366	76	equally	equally	ADV
cusj-5580	1366	77	to	to	ADP
cusj-5580	1366	78	the	the	DET
cusj-5580	1366	79	design	design	NOUN
cusj-5580	1366	80	,	,	PUNCT
cusj-5580	1366	81	modeling	modeling	NOUN
cusj-5580	1366	82	,	,	PUNCT
cusj-5580	1366	83	analysis	analysis	NOUN
cusj-5580	1366	84	,	,	PUNCT
cusj-5580	1366	85	and	and	CCONJ
cusj-5580	1366	86	write	write	VERB
cusj-5580	1366	87	up	up	ADP
cusj-5580	1366	88	of	of	ADP
cusj-5580	1366	89	the	the	DET
cusj-5580	1366	90	article	article	NOUN
cusj-5580	1366	91	.	.	PUNCT
cusj-5580	1367	1	funding	funding	NOUN
cusj-5580	1367	2	sources	source	NOUN
cusj-5580	1367	3	no	no	DET
cusj-5580	1367	4	funding	funding	NOUN
cusj-5580	1367	5	sources	source	NOUN
cusj-5580	1367	6	to	to	PART
cusj-5580	1367	7	disclose	disclose	VERB
cusj-5580	1367	8	.	.	PUNCT
cusj-5580	1368	1	acknowledgment	acknowledgment	NOUN
cusj-5580	1368	2	we	we	PRON
cusj-5580	1368	3	would	would	AUX
cusj-5580	1368	4	like	like	VERB
cusj-5580	1368	5	to	to	PART
cusj-5580	1368	6	thank	thank	VERB
cusj-5580	1368	7	professor	professor	PROPN
cusj-5580	1368	8	devinder	devinder	PROPN
cusj-5580	1368	9	mahajan	mahajan	PROPN
cusj-5580	1368	10	for	for	ADP
cusj-5580	1368	11	his	his	PRON
cusj-5580	1368	12	guidance	guidance	NOUN
cusj-5580	1368	13	on	on	ADP
cusj-5580	1368	14	this	this	DET
cusj-5580	1368	15	project	project	NOUN
cusj-5580	1368	16	.	.	PUNCT
cusj-5580	1369	1	references	reference	NOUN
cusj-5580	1369	2	[	[	X
cusj-5580	1369	3	1	1	NUM
cusj-5580	1369	4	]	]	PUNCT
cusj-5580	1369	5	h.	h.	PROPN
cusj-5580	1369	6	kantarjian	kantarjian	PROPN
cusj-5580	1369	7	,	,	PUNCT
cusj-5580	1369	8	s.	s.	PROPN
cusj-5580	1369	9	o’brien	o’brien	PROPN
cusj-5580	1369	10	,	,	PUNCT
cusj-5580	1369	11	e.	e.	PROPN
cusj-5580	1369	12	jabbour	jabbour	PROPN
cusj-5580	1369	13	,	,	PUNCT
cusj-5580	1369	14	et	et	PROPN
cusj-5580	1369	15	al	al	PROPN
cusj-5580	1369	16	.	.	PROPN
cusj-5580	1369	17	,	,	PUNCT
cusj-5580	1369	18	and	and	CCONJ
cusj-5580	1369	19	j.	j.	PROPN
cusj-5580	1369	20	cortes	cortes	PROPN
cusj-5580	1369	21	,	,	PUNCT
cusj-5580	1369	22	blood	blood	NOUN
cusj-5580	1369	23	,	,	PUNCT
cusj-5580	1369	24	2012	2012	NUM
cusj-5580	1369	25	,	,	PUNCT
cusj-5580	1369	26	119(9	119(9	NUM
cusj-5580	1369	27	)	)	PUNCT
cusj-5580	1369	28	,	,	PUNCT
cusj-5580	1369	29	1981–1987	1981–1987	NUM
cusj-5580	1369	30	.	.	PUNCT
cusj-5580	1370	1	http://www.bloodjournal.org/content/117/6/1822.lo	http://www.bloodjournal.org/content/117/6/1822.lo	PROPN
cusj-5580	1370	2	ng?sso	ng?sso	NOUN
cusj-5580	1370	3	-	-	PUNCT
cusj-5580	1370	4	checked	check	VERB
cusj-5580	1370	5	=	=	ADJ
cusj-5580	1370	6	true	true	ADJ
cusj-5580	1370	7	[	[	X
cusj-5580	1370	8	2	2	NUM
cusj-5580	1370	9	]	]	X
cusj-5580	1370	10	national	national	PROPN
cusj-5580	1370	11	cancer	cancer	PROPN
cusj-5580	1370	12	institute	institute	PROPN
cusj-5580	1370	13	,	,	PUNCT
cusj-5580	1370	14	cancer	cancer	NOUN
cusj-5580	1370	15	stat	stat	PROPN
cusj-5580	1370	16	facts	fact	VERB
cusj-5580	1370	17	:	:	PUNCT
cusj-5580	1370	18	leukemia	leukemia	NOUN
cusj-5580	1370	19	chronic	chronic	ADJ
cusj-5580	1370	20	myeloid	myeloid	NOUN
cusj-5580	1370	21	leukemia	leukemia	NOUN
cusj-5580	1370	22	,	,	PUNCT
cusj-5580	1370	23	surveillance	surveillance	NOUN
cusj-5580	1370	24	,	,	PUNCT
cusj-5580	1370	25	epidemiology	epidemiology	NOUN
cusj-5580	1370	26	,	,	PUNCT
cusj-5580	1370	27	and	and	CCONJ
cusj-5580	1370	28	end	end	VERB
cusj-5580	1370	29	results	result	NOUN
cusj-5580	1370	30	program	program	NOUN
cusj-5580	1370	31	,	,	PUNCT
cusj-5580	1370	32	2014	2014	NUM
cusj-5580	1370	33	.	.	PUNCT
cusj-5580	1371	1	https://seer.cancer.gov/statfacts/html/cmyl.html	https://seer.cancer.gov/statfacts/html/cmyl.html	X
cusj-5580	1372	1	[	[	X
cusj-5580	1372	2	3	3	X
cusj-5580	1372	3	]	]	X
cusj-5580	1372	4	w.	w.	PROPN
cusj-5580	1372	5	huang	huang	PROPN
cusj-5580	1372	6	,	,	PUNCT
cusj-5580	1372	7	w.	w.	PROPN
cusj-5580	1372	8	c.	c.	PROPN
cusj-5580	1372	9	shakespeare	shakespeare	PROPN
cusj-5580	1372	10	,	,	PUNCT
cusj-5580	1372	11	synthesis	synthesis	NOUN
cusj-5580	1372	12	,	,	PUNCT
cusj-5580	1372	13	2007	2007	NUM
cusj-5580	1372	14	,	,	PUNCT
cusj-5580	1372	15	14	14	NUM
cusj-5580	1372	16	,	,	PUNCT
cusj-5580	1372	17	2121	2121	NUM
cusj-5580	1372	18	-	-	SYM
cusj-5580	1372	19	2124	2124	NUM
cusj-5580	1372	20	.	.	PUNCT
cusj-5580	1373	1	https://www.thiemeconnect.com/products/ejournals/html/10.1055/s2007-983754	https://www.thiemeconnect.com/products/ejournals/html/10.1055/s2007-983754	PROPN
cusj-5580	1374	1	[	[	X
cusj-5580	1374	2	4	4	NUM
cusj-5580	1374	3	]	]	PUNCT
cusj-5580	1374	4	bloudek	bloudek	NOUN
cusj-5580	1374	5	,	,	PUNCT
cusj-5580	1374	6	l.	l.	PROPN
cusj-5580	1374	7	m.	m.	PROPN
cusj-5580	1374	8	,	,	PUNCT
cusj-5580	1374	9	makenbaeva	makenbaeva	PROPN
cusj-5580	1374	10	,	,	PUNCT
cusj-5580	1374	11	d.	d.	PROPN
cusj-5580	1374	12	,	,	PUNCT
cusj-5580	1374	13	&	&	CCONJ
cusj-5580	1374	14	eaddy	eaddy	PROPN
cusj-5580	1374	15	,	,	PUNCT
cusj-5580	1374	16	m.	m.	NOUN
cusj-5580	1374	17	am	be	AUX
cusj-5580	1374	18	.	.	PUNCT
cusj-5580	1375	1	health	health	NOUN
cusj-5580	1375	2	drug	drug	NOUN
cusj-5580	1375	3	benefits	benefit	NOUN
cusj-5580	1375	4	,	,	PUNCT
cusj-5580	1375	5	2015	2015	NUM
cusj-5580	1375	6	,	,	PUNCT
cusj-5580	1375	7	8(9	8(9	NUM
cusj-5580	1375	8	):	):	PUNCT
cusj-5580	1375	9	472–480	472–480	NUM
cusj-5580	1375	10	.	.	PUNCT
cusj-5580	1376	1	https://europepmc.org/abstract/med/26834933	https://europepmc.org/abstract/med/26834933	PART
cusj-5580	1377	1	[	[	X
cusj-5580	1377	2	5	5	X
cusj-5580	1377	3	]	]	PUNCT
cusj-5580	1377	4	j.	j.	PROPN
cusj-5580	1377	5	cortes	cortes	PROPN
cusj-5580	1377	6	,	,	PUNCT
cusj-5580	1377	7	x.	x.	PROPN
cusj-5580	1377	8	huang	huang	PROPN
cusj-5580	1377	9	,	,	PUNCT
cusj-5580	1377	10	h.	h.	PROPN
cusj-5580	1377	11	kantarjian	kantarjian	PROPN
cusj-5580	1377	12	,	,	PUNCT
cusj-5580	1377	13	cancer	cancer	NOUN
cusj-5580	1377	14	,	,	PUNCT
cusj-5580	1377	15	2012	2012	NUM
cusj-5580	1377	16	,	,	PUNCT
cusj-5580	1377	17	118(12	118(12	NUM
cusj-5580	1377	18	)	)	PUNCT
cusj-5580	1377	19	,	,	PUNCT
cusj-5580	1377	20	3123	3123	NUM
cusj-5580	1377	21	-	-	SYM
cusj-5580	1377	22	3127	3127	NUM
cusj-5580	1377	23	.	.	PUNCT
cusj-5580	1378	1	https://onlinelibrary.wiley.com/doi/abs/10.1002/cn	https://onlinelibrary.wiley.com/doi/abs/10.1002/cn	VERB
cusj-5580	1378	2	cr.26679	cr.26679	PROPN
cusj-5580	1378	3	[	[	PUNCT
cusj-5580	1378	4	6	6	NUM
cusj-5580	1378	5	]	]	PUNCT
cusj-5580	1378	6	d.	d.	PROPN
cusj-5580	1378	7	sanford	sanford	PROPN
cusj-5580	1378	8	,	,	PUNCT
cusj-5580	1378	9	r.	r.	PROPN
cusj-5580	1378	10	kyle	kyle	PROPN
cusj-5580	1378	11	,	,	PUNCT
cusj-5580	1378	12	a.	a.	PROPN
cusj-5580	1378	13	lazo	lazo	PROPN
cusj-5580	1378	14	-	-	PUNCT
cusj-5580	1378	15	langer	langer	PROPN
cusj-5580	1378	16	,	,	PUNCT
cusj-5580	1378	17	a.	a.	NOUN
cusj-5580	1378	18	xenocostas	xenocostas	PROPN
cusj-5580	1378	19	,	,	PUNCT
cusj-5580	1378	20	i.	i.	PROPN
cusj-5580	1378	21	chin	chin	PROPN
cusj-5580	1378	22	-	-	PUNCT
cusj-5580	1378	23	yee	yee	PROPN
cusj-5580	1378	24	,	,	PUNCT
cusj-5580	1378	25	k.	k.	PROPN
cusj-5580	1378	26	howson	howson	PROPN
cusj-5580	1378	27	-	-	PUNCT
cusj-5580	1378	28	jan	jan	PROPN
cusj-5580	1378	29	,	,	PUNCT
cusj-5580	1378	30	c.	c.	PROPN
cusj-5580	1378	31	hsia	hsia	PROPN
cusj-5580	1378	32	,	,	PUNCT
cusj-5580	1378	33	current	current	ADJ
cusj-5580	1378	34	oncology	oncology	NOUN
cusj-5580	1378	35	,	,	PUNCT
cusj-5580	1378	36	2014	2014	NUM
cusj-5580	1378	37	,	,	PUNCT
cusj-5580	1378	38	21(2	21(2	NUM
cusj-5580	1378	39	)	)	PUNCT
cusj-5580	1378	40	,	,	PUNCT
cusj-5580	1378	41	241	241	PROPN
cusj-5580	1378	42	-	-	SYM
cusj-5580	1378	43	249	249	NUM
cusj-5580	1378	44	.	.	PUNCT
cusj-5580	1379	1	http://www.currentoncology.com/index.php/oncology/article/view/173	http://www.currentoncology.com/index.php/oncology/article/view/173	PROPN
cusj-5580	1379	2	6/1479	6/1479	PROPN
cusj-5580	1380	1	[	[	X
cusj-5580	1380	2	7	7	X
cusj-5580	1380	3	]	]	X
cusj-5580	1380	4	national	national	PROPN
cusj-5580	1380	5	cancer	cancer	PROPN
cusj-5580	1380	6	institute	institute	PROPN
cusj-5580	1380	7	,	,	PUNCT
cusj-5580	1380	8	fda	fda	PROPN
cusj-5580	1380	9	approval	approval	NOUN
cusj-5580	1380	10	for	for	ADP
cusj-5580	1380	11	nilotinib	nilotinib	NOUN
cusj-5580	1380	12	,	,	PUNCT
cusj-5580	1380	13	national	national	ADJ
cusj-5580	1380	14	institutes	institutes	PROPN
cusj-5580	1380	15	of	of	ADP
cusj-5580	1380	16	health	health	NOUN
cusj-5580	1380	17	,	,	PUNCT
cusj-5580	1380	18	2013	2013	NUM
cusj-5580	1380	19	.	.	PUNCT
cusj-5580	1381	1	[	[	X
cusj-5580	1381	2	8	8	NUM
cusj-5580	1381	3	]	]	X
cusj-5580	1381	4	h.	h.	PROPN
cusj-5580	1381	5	kantarjian	kantarjian	PROPN
cusj-5580	1381	6	.	.	PUNCT
cusj-5580	1382	1	the	the	DET
cusj-5580	1382	2	arrival	arrival	NOUN
cusj-5580	1382	3	of	of	ADP
cusj-5580	1382	4	generic	generic	ADJ
cusj-5580	1382	5	imatinib	imatinib	NOUN
cusj-5580	1382	6	into	into	ADP
cusj-5580	1382	7	the	the	DET
cusj-5580	1382	8	u.s	u.s	PROPN
cusj-5580	1382	9	.	.	PROPN
cusj-5580	1382	10	market	market	NOUN
cusj-5580	1382	11	:	:	PUNCT
cusj-5580	1382	12	an	an	DET
cusj-5580	1382	13	educational	educational	ADJ
cusj-5580	1382	14	event	event	NOUN
cusj-5580	1382	15	.	.	PUNCT
cusj-5580	1383	1	the	the	DET
cusj-5580	1383	2	asco	asco	PROPN
cusj-5580	1383	3	post	post	NOUN
cusj-5580	1383	4	,	,	PUNCT
cusj-5580	1383	5	2016	2016	NUM
cusj-5580	1383	6	.	.	PUNCT
cusj-5580	1384	1	http://www.ascopost.com/issues/may-252016/the-arrival-of-generic-imatinib-into-the-usmarket-an-educational-event/	http://www.ascopost.com/issues/may-252016/the-arrival-of-generic-imatinib-into-the-usmarket-an-educational-event/	PROPN
cusj-5580	1384	2	cusj	cusj	VERB
cusj-5580	1384	3	2019	2019	NUM
cusj-5580	1384	4	_	_	PUNCT
cusj-5580	1385	1	_	_	PUNCT
cusj-5580	1386	1	_	_	PUNCT
cusj-5580	1387	1	_	_	PUNCT
cusj-5580	1388	1	_	_	PUNCT
cusj-5580	1389	1	_	_	PUNCT
cusj-5580	1390	1	_	_	PUNCT
cusj-5580	1391	1	_	_	PUNCT
cusj-5580	1392	1	_	_	PUNCT
cusj-5580	1393	1	_	_	PUNCT
cusj-5580	1394	1	_	_	PUNCT
cusj-5580	1395	1	_	_	PUNCT
cusj-5580	1396	1	_	_	PUNCT
cusj-5580	1397	1	_	_	PUNCT
cusj-5580	1398	1	_	_	PUNCT
cusj-5580	1399	1	_	_	PUNCT
cusj-5580	1400	1	_	_	PUNCT
cusj-5580	1401	1	_	_	PUNCT
cusj-5580	1402	1	_	_	PUNCT
cusj-5580	1403	1	_	_	PUNCT
cusj-5580	1404	1	_	_	PUNCT
cusj-5580	1405	1	_	_	PUNCT
cusj-5580	1406	1	_	_	PUNCT
cusj-5580	1407	1	_	_	PUNCT
cusj-5580	1408	1	_	_	PUNCT
cusj-5580	1409	1	_	_	PUNCT
cusj-5580	1410	1	_	_	PUNCT
cusj-5580	1411	1	_	_	PUNCT
cusj-5580	1412	1	_	_	PUNCT
cusj-5580	1413	1	_	_	PUNCT
cusj-5580	1414	1	_	_	PUNCT
cusj-5580	1415	1	_	_	PUNCT
cusj-5580	1416	1	_	_	PUNCT
cusj-5580	1417	1	_	_	PUNCT
cusj-5580	1418	1	_	_	PUNCT
cusj-5580	1419	1	_	_	PUNCT
cusj-5580	1420	1	_	_	PUNCT
cusj-5580	1421	1	_	_	PUNCT
cusj-5580	1422	1	_	_	PUNCT
cusj-5580	1423	1	_	_	PUNCT
cusj-5580	1424	1	_	_	PUNCT
cusj-5580	1425	1	_	_	PUNCT
cusj-5580	1426	1	_	_	PUNCT
cusj-5580	1427	1	_	_	PUNCT
cusj-5580	1428	1	_	_	PUNCT
cusj-5580	1429	1	_	_	PUNCT
cusj-5580	1430	1	_	_	PUNCT
cusj-5580	1431	1	_	_	PUNCT
cusj-5580	1432	1	_	_	PUNCT
cusj-5580	1433	1	_	_	PUNCT
cusj-5580	1434	1	_	_	PUNCT
cusj-5580	1435	1	_	_	PUNCT
cusj-5580	1436	1	_	_	PUNCT
cusj-5580	1437	1	_	_	PUNCT
cusj-5580	1438	1	_	_	PUNCT
cusj-5580	1439	1	_	_	PUNCT
cusj-5580	1440	1	_	_	PUNCT
cusj-5580	1441	1	_	_	PUNCT
cusj-5580	1442	1	_	_	PUNCT
cusj-5580	1443	1	_	_	PUNCT
cusj-5580	1444	1	_	_	PUNCT
cusj-5580	1445	1	_	_	PUNCT
cusj-5580	1446	1	_	_	PUNCT
cusj-5580	1447	1	_	_	PUNCT
cusj-5580	1448	1	_	_	PUNCT
cusj-5580	1449	1	_	_	PUNCT
cusj-5580	1450	1	_	_	PUNCT
cusj-5580	1451	1	_	_	PUNCT
cusj-5580	1452	1	_	_	PUNCT
cusj-5580	1453	1	_	_	PUNCT
cusj-5580	1454	1	_	_	PUNCT
cusj-5580	1455	1	_	_	PUNCT
cusj-5580	1456	1	_	_	PUNCT
cusj-5580	1457	1	_	_	PUNCT
cusj-5580	1458	1	_	_	PUNCT
cusj-5580	1459	1	_	_	PUNCT
cusj-5580	1460	1	_	_	PUNCT
cusj-5580	1461	1	_	_	PUNCT
cusj-5580	1462	1	_	_	PUNCT
cusj-5580	1463	1	_	_	PUNCT
cusj-5580	1464	1	_	_	PUNCT
cusj-5580	1465	1	_	_	PUNCT
cusj-5580	1466	1	_	_	PUNCT
cusj-5580	1467	1	_	_	PUNCT
cusj-5580	1468	1	_	_	PUNCT
cusj-5580	1469	1	_	_	PUNCT
cusj-5580	1470	1	_	_	PUNCT
cusj-5580	1471	1	_	_	PUNCT
cusj-5580	1472	1	_	_	PUNCT
cusj-5580	1473	1	_	_	PUNCT
cusj-5580	1474	1	_	_	PUNCT
cusj-5580	1475	1	_	_	PUNCT
cusj-5580	1476	1	_	_	PUNCT
cusj-5580	1477	1	_	_	PUNCT
cusj-5580	1478	1	_	_	PUNCT
cusj-5580	1479	1	_	_	PUNCT
cusj-5580	1480	1	_	_	PUNCT
cusj-5580	1481	1	_	_	PUNCT
cusj-5580	1482	1	_	_	PUNCT
cusj-5580	1483	1	_	_	PUNCT
cusj-5580	1484	1	_	_	PUNCT
cusj-5580	1485	1	_	_	PUNCT
cusj-5580	1486	1	_	_	PUNCT
cusj-5580	1487	1	_	_	PUNCT
cusj-5580	1488	1	_	_	PUNCT
cusj-5580	1489	1	_	_	PUNCT
cusj-5580	1490	1	_	_	PUNCT
cusj-5580	1491	1	_	_	PUNCT
cusj-5580	1492	1	_	_	PUNCT
cusj-5580	1493	1	_	_	PUNCT
cusj-5580	1494	1	_	_	PUNCT
cusj-5580	1495	1	_	_	PUNCT
cusj-5580	1496	1	_	_	PUNCT
cusj-5580	1497	1	_	_	PUNCT
cusj-5580	1498	1	_	_	PUNCT
cusj-5580	1499	1	_	_	PUNCT
cusj-5580	1500	1	_	_	PUNCT
cusj-5580	1501	1	_	_	PUNCT
cusj-5580	1502	1	_	_	PUNCT
cusj-5580	1503	1	_	_	PUNCT
cusj-5580	1504	1	_	_	PUNCT
cusj-5580	1505	1	_	_	PUNCT
cusj-5580	1506	1	_	_	PUNCT
cusj-5580	1507	1	_	_	PUNCT
cusj-5580	1508	1	_	_	PUNCT
cusj-5580	1509	1	_	_	PUNCT
cusj-5580	1510	1	_	_	PUNCT
cusj-5580	1511	1	_	_	PUNCT
cusj-5580	1512	1	_	_	PUNCT
cusj-5580	1513	1	_	_	PUNCT
cusj-5580	1514	1	_	_	PUNCT
cusj-5580	1515	1	_	_	PUNCT
cusj-5580	1516	1	_	_	PUNCT
cusj-5580	1517	1	_	_	PUNCT
cusj-5580	1518	1	_	_	PUNCT
cusj-5580	1519	1	_	_	PUNCT
cusj-5580	1520	1	_	_	PUNCT
cusj-5580	1521	1	_	_	PUNCT
cusj-5580	1522	1	_	_	PUNCT
cusj-5580	1523	1	_	_	PUNCT
cusj-5580	1524	1	_	_	PUNCT
cusj-5580	1525	1	_	_	PUNCT
cusj-5580	1526	1	_	_	PUNCT
cusj-5580	1527	1	_	_	PUNCT
cusj-5580	1528	1	_	_	PUNCT
cusj-5580	1529	1	_	_	PUNCT
cusj-5580	1530	1	_	_	PUNCT
cusj-5580	1531	1	_	_	PUNCT
cusj-5580	1532	1	_	_	PUNCT
cusj-5580	1533	1	_	_	PUNCT
cusj-5580	1534	1	_	_	PUNCT
cusj-5580	1535	1	_	_	PUNCT
cusj-5580	1536	1	_	_	PUNCT
cusj-5580	1537	1	_	_	PUNCT
cusj-5580	1538	1	_	_	PUNCT
cusj-5580	1539	1	_	_	PUNCT
cusj-5580	1540	1	_	_	PUNCT
cusj-5580	1541	1	_	_	PUNCT
cusj-5580	1542	1	_	_	PUNCT
cusj-5580	1543	1	_	_	PUNCT
cusj-5580	1544	1	_	_	PUNCT
cusj-5580	1545	1	_	_	PUNCT
cusj-5580	1546	1	_	_	PUNCT
cusj-5580	1547	1	_	_	PUNCT
cusj-5580	1548	1	_	_	PUNCT
cusj-5580	1549	1	_	_	PUNCT
cusj-5580	1550	1	_	_	PUNCT
cusj-5580	1551	1	_	_	PUNCT
cusj-5580	1552	1	_	_	PUNCT
cusj-5580	1553	1	_	_	PUNCT
cusj-5580	1554	1	28	28	NUM
cusj-5580	1555	1	[	[	X
cusj-5580	1555	2	9	9	NUM
cusj-5580	1555	3	]	]	PUNCT
cusj-5580	1555	4	w.	w.	PROPN
cusj-5580	1555	5	breitenstein	breitenstein	PROPN
cusj-5580	1555	6	,	,	PUNCT
cusj-5580	1555	7	p.	p.	PROPN
cusj-5580	1555	8	furet	furet	PROPN
cusj-5580	1555	9	,	,	PUNCT
cusj-5580	1555	10	s.	s.	PROPN
cusj-5580	1555	11	jacob	jacob	PROPN
cusj-5580	1555	12	,	,	PUNCT
cusj-5580	1555	13	p.	p.	PROPN
cusj-5580	1555	14	w.	w.	PROPN
cusj-5580	1555	15	manley	manley	PROPN
cusj-5580	1555	16	,	,	PUNCT
cusj-5580	1555	17	united	united	PROPN
cusj-5580	1555	18	states	states	PROPN
cusj-5580	1555	19	patent	patent	PROPN
cusj-5580	1555	20	and	and	CCONJ
cusj-5580	1555	21	trademark	trademark	NOUN
cusj-5580	1555	22	office	office	NOUN
cusj-5580	1555	23	,	,	PUNCT
cusj-5580	1555	24	2004	2004	NUM
cusj-5580	1555	25	,	,	PUNCT
cusj-5580	1555	26	patent	patent	NOUN
cusj-5580	1555	27	publication	publication	NOUN
cusj-5580	1555	28	no	no	INTJ
cusj-5580	1555	29	.	.	PUNCT
cusj-5580	1556	1	wo/2004/005281	wo/2004/005281	PROPN
cusj-5580	1556	2	.	.	PUNCT
cusj-5580	1557	1	https://patentscope.wipo.int/search/en/detail.jsf%3	https://patentscope.wipo.int/search/en/detail.jsf%3	NUM
cusj-5580	1557	2	bjsessionid=39aea7187733e9827dc0bbb00f07b9d3	bjsessionid=39aea7187733e9827dc0bbb00f07b9d3	NUM
cusj-5580	1557	3	.	.	PUNCT
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cusj-5580	1558	2	=	=	SYM
cusj-5580	1558	3	wo2004005281&recnum=94&office=	wo2004005281&recnum=94&office=	NOUN
cusj-5580	1558	4	&	&	CCONJ
cusj-5580	1558	5	prevfilter=%2526fq%253dof%253akr%2526fq%253	prevfilter=%2526fq%253dof%253akr%2526fq%253	PROPN
cusj-5580	1558	6	dicf_m%253a%252522c07d%252522%2526fq%253d	dicf_m%253a%252522c07d%252522%2526fq%253d	PROPN
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cusj-5580	1558	9	sortoption	sortoption	NOUN
cusj-5580	1558	10	=	=	NOUN
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cusj-5580	1558	13	10	10	NUM
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cusj-5580	1558	15	b.	b.	PROPN
cusj-5580	1558	16	j.	j.	PROPN
cusj-5580	1558	17	deadman	deadman	PROPN
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cusj-5580	1558	19	m.	m.	PROPN
cusj-5580	1558	20	d.	d.	PROPN
cusj-5580	1558	21	hopkin	hopkin	PROPN
cusj-5580	1558	22	,	,	PUNCT
cusj-5580	1558	23	i.	i.	PROPN
cusj-5580	1558	24	r.	r.	PROPN
cusj-5580	1558	25	baxendale	baxendale	PROPN
cusj-5580	1558	26	,	,	PUNCT
cusj-5580	1558	27	s.	s.	PROPN
cusj-5580	1558	28	v.	v.	PROPN
cusj-5580	1558	29	ley	ley	PROPN
cusj-5580	1558	30	,	,	PUNCT
cusj-5580	1558	31	org	org	PROPN
cusj-5580	1558	32	.	.	PUNCT
cusj-5580	1558	33	biomol	biomol	PROPN
cusj-5580	1558	34	.	.	PUNCT
cusj-5580	1558	35	chem	chem	PROPN
cusj-5580	1558	36	.	.	PUNCT
cusj-5580	1558	37	,	,	PUNCT
cusj-5580	1558	38	2013	2013	NUM
cusj-5580	1558	39	,	,	PUNCT
cusj-5580	1558	40	11(11	11(11	NUM
cusj-5580	1558	41	)	)	PUNCT
cusj-5580	1558	42	,	,	PUNCT
cusj-5580	1558	43	1766	1766	NUM
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cusj-5580	1558	45	1800	1800	NUM
cusj-5580	1558	46	.	.	PUNCT
cusj-5580	1559	1	https://www.ncbi.nlm.nih.gov/pubmed/23247657	https://www.ncbi.nlm.nih.gov/pubmed/23247657	X
cusj-5580	1560	1	[	[	X
cusj-5580	1560	2	11	11	NUM
cusj-5580	1560	3	]	]	X
cusj-5580	1560	4	y.	y.	PROPN
cusj-5580	1560	5	chen	chen	PROPN
cusj-5580	1560	6	,	,	PUNCT
cusj-5580	1560	7	l.	l.	PROPN
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cusj-5580	1560	9	,	,	PUNCT
cusj-5580	1560	10	h.	h.	PROPN
cusj-5580	1560	11	zhou	zhou	PROPN
cusj-5580	1560	12	,	,	PUNCT
cusj-5580	1560	13	c.	c.	PROPN
cusj-5580	1560	14	wang	wang	PROPN
cusj-5580	1560	15	,	,	PUNCT
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cusj-5580	1560	17	yiyao	yiyao	PROPN
cusj-5580	1560	18	gongye	gongye	PROPN
cusj-5580	1560	19	zazhi	zazhi	PROPN
cusj-5580	1560	20	,	,	PUNCT
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cusj-5580	1560	22	,	,	PUNCT
cusj-5580	1560	23	40	40	NUM
cusj-5580	1560	24	,	,	PUNCT
cusj-5580	1560	25	401–403	401–403	NUM
cusj-5580	1560	26	.	.	PUNCT
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cusj-5580	1561	2	55640	55640	NUM
cusj-5580	1561	3	/	/	SYM
cusj-5580	1561	4	zhongguo	zhongguo	PROPN
cusj-5580	1561	5	-	-	PUNCT
cusj-5580	1561	6	yiyao	yiyao	NOUN
cusj-5580	1561	7	-	-	PUNCT
cusj-5580	1561	8	gongye	gongye	NOUN
cusj-5580	1561	9	-	-	PUNCT
cusj-5580	1561	10	zazhi/	zazhi/	NUM
cusj-5580	1561	11	[	[	X
cusj-5580	1561	12	12	12	NUM
cusj-5580	1561	13	]	]	PUNCT
cusj-5580	1561	14	a.	a.	NOUN
cusj-5580	1561	15	yeori	yeori	PROPN
cusj-5580	1561	16	,	,	PUNCT
cusj-5580	1561	17	y.	y.	PROPN
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cusj-5580	1561	21	li	li	PROPN
cusj-5580	1561	22	,	,	PUNCT
cusj-5580	1561	23	j.	j.	PROPN
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cusj-5580	1561	25	,	,	PUNCT
cusj-5580	1561	26	r.	r.	PROPN
cusj-5580	1561	27	lifshitz	lifshitz	PROPN
cusj-5580	1561	28	-	-	PUNCT
cusj-5580	1561	29	liron	liron	PROPN
cusj-5580	1561	30	,	,	PUNCT
cusj-5580	1561	31	x	x	PRON
cusj-5580	1561	32	,	,	PUNCT
cusj-5580	1561	33	he	he	PRON
cusj-5580	1561	34	,	,	PUNCT
cusj-5580	1561	35	united	united	PROPN
cusj-5580	1561	36	states	states	PROPN
cusj-5580	1561	37	patent	patent	PROPN
cusj-5580	1561	38	and	and	CCONJ
cusj-5580	1561	39	trademark	trademark	NOUN
cusj-5580	1561	40	office	office	NOUN
cusj-5580	1561	41	,	,	PUNCT
cusj-5580	1561	42	2010	2010	NUM
cusj-5580	1561	43	,	,	PUNCT
cusj-5580	1561	44	patent	patent	NOUN
cusj-5580	1561	45	publication	publication	NOUN
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cusj-5580	1561	47	.	.	PUNCT
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cusj-5580	1562	2	.	.	PUNCT
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cusj-5580	1563	2	cid	cid	NOUN
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cusj-5580	1563	6	13	13	NUM
cusj-5580	1563	7	]	]	PUNCT
cusj-5580	1563	8	s.	s.	PROPN
cusj-5580	1563	9	ueda	ueda	PROPN
cusj-5580	1563	10	,	,	PUNCT
cusj-5580	1563	11	m.	m.	PROPN
cusj-5580	1563	12	su	su	PROPN
cusj-5580	1563	13	,	,	PUNCT
cusj-5580	1563	14	s.	s.	PROPN
cusj-5580	1563	15	l.	l.	PROPN
cusj-5580	1563	16	buchwald	buchwald	PROPN
cusj-5580	1563	17	,	,	PUNCT
cusj-5580	1563	18	j.	j.	PROPN
cusj-5580	1563	19	of	of	ADP
cusj-5580	1563	20	the	the	DET
cusj-5580	1563	21	american	american	PROPN
cusj-5580	1563	22	chemical	chemical	PROPN
cusj-5580	1563	23	society	society	PROPN
cusj-5580	1563	24	,	,	PUNCT
cusj-5580	1563	25	2012	2012	NUM
cusj-5580	1563	26	,	,	PUNCT
cusj-5580	1563	27	134(1	134(1	NUM
cusj-5580	1563	28	)	)	PUNCT
cusj-5580	1563	29	,	,	PUNCT
cusj-5580	1563	30	700	700	NUM
cusj-5580	1563	31	-	-	SYM
cusj-5580	1563	32	706	706	NUM
cusj-5580	1563	33	.	.	PUNCT
cusj-5580	1563	34	https://pubs.acs.org/doi/abs/10.1021/ja2102373	https://pubs.acs.org/doi/abs/10.1021/ja2102373	NOUN
cusj-5580	1564	1	[	[	X
cusj-5580	1564	2	14	14	NUM
cusj-5580	1564	3	]	]	PUNCT
cusj-5580	1564	4	m.	m.	PROPN
cusj-5580	1564	5	d.	d.	PROPN
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cusj-5580	1564	7	,	,	PUNCT
cusj-5580	1564	8	i.	i.	PROPN
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cusj-5580	1564	12	s.	s.	PROPN
cusj-5580	1564	13	v.	v.	PROPN
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cusj-5580	1564	16	rsc	rsc	PROPN
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cusj-5580	1564	18	,	,	PUNCT
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cusj-5580	1564	23	2450	2450	NUM
cusj-5580	1564	24	-	-	SYM
cusj-5580	1564	25	2452	2452	NUM
cusj-5580	1564	26	.	.	PUNCT
cusj-5580	1565	1	https://pubs.rsc.org/en/content/articlelanding/2010	https://pubs.rsc.org/en/content/articlelanding/2010	ADJ
cusj-5580	1565	2	/cc	/cc	PUNCT
cusj-5580	1565	3	/	/	SYM
cusj-5580	1565	4	c001550d#!divabstract	c001550d#!divabstract	NOUN