id	sid	tid	token	lemma	pos
cusj-5588	1	1	treating	treat	VERB
cusj-5588	1	2	neurodegenerative	neurodegenerative	ADJ
cusj-5588	1	3	disorders	disorder	NOUN
cusj-5588	1	4	:	:	PUNCT
cusj-5588	1	5	towards	towards	ADP
cusj-5588	1	6	detailed	detailed	ADJ
cusj-5588	1	7	pathophysiology	pathophysiology	NOUN
cusj-5588	1	8	and	and	CCONJ
cusj-5588	1	9	precision	precision	NOUN
cusj-5588	1	10	medicine	medicine	NOUN
cusj-5588	1	11	cusj	cusj	VERB
cusj-5588	1	12	2018	2018	NUM
cusj-5588	1	13	_	_	PUNCT
cusj-5588	2	1	_	_	PUNCT
cusj-5588	3	1	_	_	PUNCT
cusj-5588	4	1	_	_	PUNCT
cusj-5588	5	1	_	_	PUNCT
cusj-5588	6	1	_	_	PUNCT
cusj-5588	7	1	_	_	PUNCT
cusj-5588	8	1	_	_	PUNCT
cusj-5588	9	1	_	_	PUNCT
cusj-5588	10	1	_	_	PUNCT
cusj-5588	11	1	_	_	PUNCT
cusj-5588	12	1	_	_	PUNCT
cusj-5588	13	1	_	_	PUNCT
cusj-5588	14	1	_	_	PUNCT
cusj-5588	15	1	_	_	PUNCT
cusj-5588	16	1	_	_	PUNCT
cusj-5588	17	1	_	_	PUNCT
cusj-5588	18	1	_	_	PUNCT
cusj-5588	19	1	_	_	PUNCT
cusj-5588	20	1	_	_	PUNCT
cusj-5588	21	1	_	_	PUNCT
cusj-5588	22	1	_	_	PUNCT
cusj-5588	23	1	_	_	PUNCT
cusj-5588	24	1	_	_	PUNCT
cusj-5588	25	1	_	_	PUNCT
cusj-5588	26	1	_	_	PUNCT
cusj-5588	27	1	_	_	PUNCT
cusj-5588	28	1	_	_	PUNCT
cusj-5588	29	1	_	_	PUNCT
cusj-5588	30	1	_	_	PUNCT
cusj-5588	31	1	_	_	PUNCT
cusj-5588	32	1	_	_	PUNCT
cusj-5588	33	1	_	_	PUNCT
cusj-5588	34	1	_	_	PUNCT
cusj-5588	35	1	_	_	PUNCT
cusj-5588	36	1	_	_	PUNCT
cusj-5588	37	1	_	_	PUNCT
cusj-5588	38	1	_	_	PUNCT
cusj-5588	39	1	_	_	PUNCT
cusj-5588	40	1	_	_	PUNCT
cusj-5588	41	1	_	_	PUNCT
cusj-5588	42	1	_	_	PUNCT
cusj-5588	43	1	_	_	PUNCT
cusj-5588	44	1	_	_	PUNCT
cusj-5588	45	1	_	_	PUNCT
cusj-5588	46	1	_	_	PUNCT
cusj-5588	47	1	_	_	PUNCT
cusj-5588	48	1	_	_	PUNCT
cusj-5588	49	1	_	_	PUNCT
cusj-5588	50	1	_	_	PUNCT
cusj-5588	51	1	_	_	PUNCT
cusj-5588	52	1	_	_	PUNCT
cusj-5588	53	1	_	_	PUNCT
cusj-5588	54	1	_	_	PUNCT
cusj-5588	55	1	_	_	PUNCT
cusj-5588	56	1	_	_	PUNCT
cusj-5588	57	1	_	_	PUNCT
cusj-5588	58	1	_	_	PUNCT
cusj-5588	59	1	_	_	PUNCT
cusj-5588	60	1	_	_	PUNCT
cusj-5588	61	1	_	_	PUNCT
cusj-5588	62	1	_	_	PUNCT
cusj-5588	63	1	_	_	PUNCT
cusj-5588	64	1	_	_	PUNCT
cusj-5588	65	1	_	_	PUNCT
cusj-5588	66	1	_	_	PUNCT
cusj-5588	67	1	_	_	PUNCT
cusj-5588	68	1	_	_	PUNCT
cusj-5588	69	1	_	_	PUNCT
cusj-5588	70	1	_	_	PUNCT
cusj-5588	71	1	_	_	PUNCT
cusj-5588	72	1	_	_	PUNCT
cusj-5588	73	1	_	_	PUNCT
cusj-5588	74	1	_	_	PUNCT
cusj-5588	75	1	_	_	PUNCT
cusj-5588	76	1	_	_	PUNCT
cusj-5588	77	1	_	_	PUNCT
cusj-5588	78	1	_	_	PUNCT
cusj-5588	79	1	_	_	PUNCT
cusj-5588	80	1	_	_	PUNCT
cusj-5588	81	1	abstract	abstract	ADV
cusj-5588	81	2	—	—	PUNCT
cusj-5588	81	3	the	the	DET
cusj-5588	81	4	following	follow	VERB
cusj-5588	81	5	paper	paper	NOUN
cusj-5588	81	6	reviews	review	NOUN
cusj-5588	81	7	current	current	ADJ
cusj-5588	81	8	literature	literature	NOUN
cusj-5588	81	9	on	on	ADP
cusj-5588	81	10	disease	disease	NOUN
cusj-5588	81	11	etiology	etiology	NOUN
cusj-5588	81	12	,	,	PUNCT
cusj-5588	81	13	pathophysiology	pathophysiology	NOUN
cusj-5588	81	14	,	,	PUNCT
cusj-5588	81	15	and	and	CCONJ
cusj-5588	81	16	therapeutic	therapeutic	ADJ
cusj-5588	81	17	options	option	NOUN
cusj-5588	81	18	of	of	ADP
cusj-5588	81	19	neurodegenerative	neurodegenerative	ADJ
cusj-5588	81	20	disorder	disorder	NOUN
cusj-5588	81	21	(	(	PUNCT
cusj-5588	81	22	nds	nds	PROPN
cusj-5588	81	23	)	)	PUNCT
cusj-5588	81	24	.	.	PUNCT
cusj-5588	82	1	we	we	PRON
cusj-5588	82	2	first	first	ADV
cusj-5588	82	3	discuss	discuss	VERB
cusj-5588	82	4	current	current	ADJ
cusj-5588	82	5	directions	direction	NOUN
cusj-5588	82	6	of	of	ADP
cusj-5588	82	7	disease	disease	NOUN
cusj-5588	82	8	management	management	NOUN
cusj-5588	82	9	and	and	CCONJ
cusj-5588	82	10	treatment	treatment	NOUN
cusj-5588	82	11	,	,	PUNCT
cusj-5588	82	12	and	and	CCONJ
cusj-5588	82	13	highlight	highlight	VERB
cusj-5588	82	14	technical	technical	ADJ
cusj-5588	82	15	hindrances	hindrance	NOUN
cusj-5588	82	16	of	of	ADP
cusj-5588	82	17	current	current	ADJ
cusj-5588	82	18	gene	gene	NOUN
cusj-5588	82	19	therapy	therapy	NOUN
cusj-5588	82	20	-	-	PUNCT
cusj-5588	82	21	based	base	VERB
cusj-5588	82	22	treatments	treatment	NOUN
cusj-5588	82	23	as	as	ADV
cusj-5588	82	24	well	well	ADV
cusj-5588	82	25	as	as	ADP
cusj-5588	82	26	significant	significant	ADJ
cusj-5588	82	27	ethical	ethical	ADJ
cusj-5588	82	28	,	,	PUNCT
cusj-5588	82	29	regulatory	regulatory	ADJ
cusj-5588	82	30	,	,	PUNCT
cusj-5588	82	31	and	and	CCONJ
cusj-5588	82	32	efficacy	efficacy	NOUN
cusj-5588	82	33	-	-	PUNCT
cusj-5588	82	34	based	base	VERB
cusj-5588	82	35	concerns	concern	NOUN
cusj-5588	82	36	present	present	ADJ
cusj-5588	82	37	in	in	ADP
cusj-5588	82	38	current	current	ADJ
cusj-5588	82	39	stem	stem	NOUN
cusj-5588	82	40	cell	cell	NOUN
cusj-5588	82	41	treatment	treatment	NOUN
cusj-5588	82	42	options	option	NOUN
cusj-5588	82	43	for	for	ADP
cusj-5588	82	44	alzheimer	alzheimer	PROPN
cusj-5588	82	45	’s	’s	PART
cusj-5588	82	46	,	,	PUNCT
cusj-5588	82	47	parkinson	parkinson	NOUN
cusj-5588	82	48	’s	’s	PART
cusj-5588	82	49	and	and	CCONJ
cusj-5588	82	50	huntington	huntington	PROPN
cusj-5588	82	51	’s	’s	PART
cusj-5588	82	52	disease	disease	NOUN
cusj-5588	82	53	.	.	PUNCT
cusj-5588	83	1	we	we	PRON
cusj-5588	83	2	then	then	ADV
cusj-5588	83	3	suggest	suggest	VERB
cusj-5588	83	4	a	a	DET
cusj-5588	83	5	narrower	narrow	ADJ
cusj-5588	83	6	focus	focus	NOUN
cusj-5588	83	7	for	for	ADP
cusj-5588	83	8	future	future	ADJ
cusj-5588	83	9	research	research	NOUN
cusj-5588	83	10	on	on	ADP
cusj-5588	83	11	identifying	identify	VERB
cusj-5588	83	12	molecular	molecular	ADJ
cusj-5588	83	13	,	,	PUNCT
cusj-5588	83	14	pathological	pathological	ADJ
cusj-5588	83	15	,	,	PUNCT
cusj-5588	83	16	and	and	CCONJ
cusj-5588	83	17	biomarker	biomarker	NOUN
cusj-5588	83	18	-	-	PUNCT
cusj-5588	83	19	based	base	VERB
cusj-5588	83	20	disease	disease	NOUN
cusj-5588	83	21	progression	progression	NOUN
cusj-5588	83	22	that	that	PRON
cusj-5588	83	23	can	can	AUX
cusj-5588	83	24	in	in	ADP
cusj-5588	83	25	turn	turn	NOUN
cusj-5588	83	26	inform	inform	VERB
cusj-5588	83	27	the	the	DET
cusj-5588	83	28	development	development	NOUN
cusj-5588	83	29	of	of	ADP
cusj-5588	83	30	novel	novel	ADJ
cusj-5588	83	31	approaches	approach	NOUN
cusj-5588	83	32	in	in	ADP
cusj-5588	83	33	developing	develop	VERB
cusj-5588	83	34	nd	nd	PRON
cusj-5588	83	35	therapies	therapy	NOUN
cusj-5588	83	36	.	.	PUNCT
cusj-5588	84	1	introduction	introduction	NOUN
cusj-5588	84	2	neurodegenerative	neurodegenerative	ADJ
cusj-5588	84	3	diseases	disease	NOUN
cusj-5588	84	4	(	(	PUNCT
cusj-5588	84	5	nds	nds	NOUN
cusj-5588	84	6	)	)	PUNCT
cusj-5588	84	7	encompass	encompass	VERB
cusj-5588	84	8	a	a	DET
cusj-5588	84	9	wide	wide	ADJ
cusj-5588	84	10	range	range	NOUN
cusj-5588	84	11	of	of	ADP
cusj-5588	84	12	acute	acute	ADJ
cusj-5588	84	13	and	and	CCONJ
cusj-5588	84	14	chronic	chronic	ADJ
cusj-5588	84	15	conditions	condition	NOUN
cusj-5588	84	16	characterised	characterise	VERB
cusj-5588	84	17	by	by	ADP
cusj-5588	84	18	the	the	DET
cusj-5588	84	19	loss	loss	NOUN
cusj-5588	84	20	of	of	ADP
cusj-5588	84	21	neuron	neuron	NOUN
cusj-5588	84	22	and	and	CCONJ
cusj-5588	84	23	glial	glial	ADJ
cusj-5588	84	24	cells	cell	NOUN
cusj-5588	84	25	in	in	ADP
cusj-5588	84	26	the	the	DET
cusj-5588	84	27	brain	brain	NOUN
cusj-5588	84	28	or	or	CCONJ
cusj-5588	84	29	spinal	spinal	ADJ
cusj-5588	84	30	cord	cord	NOUN
cusj-5588	84	31	.	.	PUNCT
cusj-5588	85	1	in	in	ADP
cusj-5588	85	2	acute	acute	ADJ
cusj-5588	85	3	conditions	condition	NOUN
cusj-5588	85	4	,	,	PUNCT
cusj-5588	85	5	due	due	ADP
cusj-5588	85	6	to	to	ADP
cusj-5588	85	7	stroke	stroke	NOUN
cusj-5588	85	8	or	or	CCONJ
cusj-5588	85	9	spinal	spinal	ADJ
cusj-5588	85	10	cord	cord	NOUN
cusj-5588	85	11	injury	injury	NOUN
cusj-5588	85	12	,	,	PUNCT
cusj-5588	85	13	different	different	ADJ
cusj-5588	85	14	types	type	NOUN
cusj-5588	85	15	of	of	ADP
cusj-5588	85	16	neurons	neuron	NOUN
cusj-5588	85	17	within	within	ADP
cusj-5588	85	18	a	a	DET
cusj-5588	85	19	restricted	restricted	ADJ
cusj-5588	85	20	brain	brain	NOUN
cusj-5588	85	21	region	region	NOUN
cusj-5588	85	22	die	die	VERB
cusj-5588	85	23	over	over	ADP
cusj-5588	85	24	a	a	DET
cusj-5588	85	25	short	short	ADJ
cusj-5588	85	26	amount	amount	NOUN
cusj-5588	85	27	of	of	ADP
cusj-5588	85	28	time	time	NOUN
cusj-5588	85	29	.	.	PUNCT
cusj-5588	86	1	in	in	ADP
cusj-5588	86	2	chronic	chronic	ADJ
cusj-5588	86	3	conditions	condition	NOUN
cusj-5588	86	4	,	,	PUNCT
cusj-5588	86	5	there	there	PRON
cusj-5588	86	6	is	be	VERB
cusj-5588	86	7	either	either	CCONJ
cusj-5588	86	8	a	a	DET
cusj-5588	86	9	selective	selective	ADJ
cusj-5588	86	10	neuronal	neuronal	ADJ
cusj-5588	86	11	loss	loss	NOUN
cusj-5588	86	12	of	of	ADP
cusj-5588	86	13	specific	specific	ADJ
cusj-5588	86	14	sub	sub	NOUN
cusj-5588	86	15	-	-	NOUN
cusj-5588	86	16	populations	population	NOUN
cusj-5588	86	17	(	(	PUNCT
cusj-5588	86	18	such	such	ADJ
cusj-5588	86	19	as	as	ADP
cusj-5588	86	20	dopamine	dopamine	NOUN
cusj-5588	86	21	neurons	neuron	NOUN
cusj-5588	86	22	in	in	ADP
cusj-5588	86	23	parkinson	parkinson	NOUN
cusj-5588	86	24	’s	’s	PART
cusj-5588	86	25	or	or	CCONJ
cusj-5588	86	26	medium	medium	ADJ
cusj-5588	86	27	spiny	spiny	ADJ
cusj-5588	86	28	neuron	neuron	NOUN
cusj-5588	86	29	loss	loss	NOUN
cusj-5588	86	30	in	in	ADP
cusj-5588	86	31	huntington	huntington	PROPN
cusj-5588	86	32	’s	’s	PART
cusj-5588	86	33	disease	disease	NOUN
cusj-5588	86	34	)	)	PUNCT
cusj-5588	86	35	,	,	PUNCT
cusj-5588	86	36	or	or	CCONJ
cusj-5588	86	37	widespread	widespread	ADJ
cusj-5588	86	38	degradation	degradation	NOUN
cusj-5588	86	39	of	of	ADP
cusj-5588	86	40	many	many	ADJ
cusj-5588	86	41	neuronal	neuronal	ADJ
cusj-5588	86	42	types	type	NOUN
cusj-5588	86	43	over	over	ADP
cusj-5588	86	44	several	several	ADJ
cusj-5588	86	45	years	year	NOUN
cusj-5588	86	46	.	.	PUNCT
cusj-5588	87	1	for	for	ADP
cusj-5588	87	2	both	both	DET
cusj-5588	87	3	conditions	condition	NOUN
cusj-5588	87	4	,	,	PUNCT
cusj-5588	87	5	no	no	DET
cusj-5588	87	6	cures	cure	NOUN
cusj-5588	87	7	currently	currently	ADV
cusj-5588	87	8	exist	exist	VERB
cusj-5588	87	9	.	.	PUNCT
cusj-5588	88	1	current	current	ADJ
cusj-5588	88	2	clinical	clinical	ADJ
cusj-5588	88	3	approaches	approach	NOUN
cusj-5588	88	4	adopted	adopt	VERB
cusj-5588	88	5	can	can	AUX
cusj-5588	88	6	only	only	ADV
cusj-5588	88	7	target	target	VERB
cusj-5588	88	8	symptomatic	symptomatic	ADJ
cusj-5588	88	9	treatment	treatment	NOUN
cusj-5588	88	10	and	and	CCONJ
cusj-5588	88	11	disease	disease	NOUN
cusj-5588	88	12	management	management	NOUN
cusj-5588	88	13	,	,	PUNCT
cusj-5588	88	14	while	while	SCONJ
cusj-5588	88	15	clinical	clinical	ADJ
cusj-5588	88	16	applications	application	NOUN
cusj-5588	88	17	of	of	ADP
cusj-5588	88	18	novel	novel	ADJ
cusj-5588	88	19	therapies	therapy	NOUN
cusj-5588	88	20	developed	develop	VERB
cusj-5588	88	21	for	for	ADP
cusj-5588	88	22	nds	nd	NOUN
cusj-5588	88	23	have	have	AUX
cusj-5588	88	24	been	be	AUX
cusj-5588	88	25	limited	limit	VERB
cusj-5588	88	26	.	.	PUNCT
cusj-5588	89	1	this	this	DET
cusj-5588	89	2	paper	paper	NOUN
cusj-5588	89	3	reviews	review	VERB
cusj-5588	89	4	the	the	DET
cusj-5588	89	5	current	current	ADJ
cusj-5588	89	6	literature	literature	NOUN
cusj-5588	89	7	on	on	ADP
cusj-5588	89	8	both	both	PRON
cusj-5588	89	9	implemented	implement	VERB
cusj-5588	89	10	and	and	CCONJ
cusj-5588	89	11	developing	develop	VERB
cusj-5588	89	12	therapies	therapy	NOUN
cusj-5588	89	13	for	for	ADP
cusj-5588	89	14	alzheimer	alzheimer	PROPN
cusj-5588	89	15	’s	’s	PART
cusj-5588	89	16	(	(	PUNCT
cusj-5588	89	17	ad	ad	NOUN
cusj-5588	89	18	)	)	PUNCT
cusj-5588	89	19	,	,	PUNCT
cusj-5588	89	20	parkinson	parkinson	NOUN
cusj-5588	89	21	’s	’s	PART
cusj-5588	89	22	(	(	PUNCT
cusj-5588	89	23	pd	pd	NOUN
cusj-5588	89	24	)	)	PUNCT
cusj-5588	89	25	,	,	PUNCT
cusj-5588	89	26	and	and	CCONJ
cusj-5588	89	27	huntington	huntington	PROPN
cusj-5588	89	28	’s	’s	PART
cusj-5588	89	29	(	(	PUNCT
cusj-5588	89	30	hd	hd	NOUN
cusj-5588	89	31	)	)	PUNCT
cusj-5588	89	32	disease	disease	NOUN
cusj-5588	89	33	,	,	PUNCT
cusj-5588	89	34	three	three	NUM
cusj-5588	89	35	of	of	ADP
cusj-5588	89	36	the	the	DET
cusj-5588	89	37	most	most	ADV
cusj-5588	89	38	common	common	ADJ
cusj-5588	89	39	and	and	CCONJ
cusj-5588	89	40	debilitating	debilitate	VERB
cusj-5588	89	41	chronic	chronic	NOUN
cusj-5588	89	42	nds	nd	VERB
cusj-5588	89	43	.	.	PUNCT
cusj-5588	90	1	the	the	DET
cusj-5588	90	2	symptoms	symptom	NOUN
cusj-5588	90	3	,	,	PUNCT
cusj-5588	90	4	affected	affect	VERB
cusj-5588	90	5	brain	brain	NOUN
cusj-5588	90	6	regions	region	NOUN
cusj-5588	90	7	,	,	PUNCT
cusj-5588	90	8	and	and	CCONJ
cusj-5588	90	9	some	some	DET
cusj-5588	90	10	molecular	molecular	ADJ
cusj-5588	90	11	changes	change	NOUN
cusj-5588	90	12	have	have	AUX
cusj-5588	90	13	been	be	AUX
cusj-5588	90	14	identified	identify	VERB
cusj-5588	90	15	for	for	ADP
cusj-5588	90	16	several	several	ADJ
cusj-5588	90	17	nds	nd	NOUN
cusj-5588	90	18	,	,	PUNCT
cusj-5588	90	19	some	some	PRON
cusj-5588	90	20	of	of	ADP
cusj-5588	90	21	which	which	PRON
cusj-5588	90	22	are	be	AUX
cusj-5588	90	23	summarized	summarize	VERB
cusj-5588	90	24	in	in	ADP
cusj-5588	90	25	table	table	NOUN
cusj-5588	90	26	11	11	NUM
cusj-5588	90	27	.	.	PUNCT
cusj-5588	91	1	novel	novel	ADJ
cusj-5588	91	2	therapies	therapy	NOUN
cusj-5588	91	3	have	have	AUX
cusj-5588	91	4	been	be	AUX
cusj-5588	91	5	developed	develop	VERB
cusj-5588	91	6	in	in	ADP
cusj-5588	91	7	animal	animal	NOUN
cusj-5588	91	8	models	model	NOUN
cusj-5588	91	9	to	to	PART
cusj-5588	91	10	target	target	VERB
cusj-5588	91	11	these	these	DET
cusj-5588	91	12	observed	observe	VERB
cusj-5588	91	13	pathological	pathological	ADJ
cusj-5588	91	14	and	and	CCONJ
cusj-5588	91	15	molecular	molecular	ADJ
cusj-5588	91	16	changes	change	NOUN
cusj-5588	91	17	,	,	PUNCT
cusj-5588	91	18	but	but	CCONJ
cusj-5588	91	19	significant	significant	ADJ
cusj-5588	91	20	ethical	ethical	ADJ
cusj-5588	91	21	,	,	PUNCT
cusj-5588	91	22	economic	economic	ADJ
cusj-5588	91	23	,	,	PUNCT
cusj-5588	91	24	regulatory	regulatory	ADJ
cusj-5588	91	25	,	,	PUNCT
cusj-5588	91	26	safety	safety	NOUN
cusj-5588	91	27	,	,	PUNCT
cusj-5588	91	28	and	and	CCONJ
cusj-5588	91	29	etiological	etiological	ADJ
cusj-5588	91	30	weaknesses	weakness	NOUN
cusj-5588	91	31	still	still	ADV
cusj-5588	91	32	hinder	hinder	VERB
cusj-5588	91	33	their	their	PRON
cusj-5588	91	34	widespread	widespread	ADJ
cusj-5588	91	35	clinical	clinical	ADJ
cusj-5588	91	36	application	application	NOUN
cusj-5588	91	37	.	.	PUNCT
cusj-5588	92	1	within	within	ADP
cusj-5588	92	2	the	the	DET
cusj-5588	92	3	context	context	NOUN
cusj-5588	92	4	of	of	ADP
cusj-5588	92	5	the	the	DET
cusj-5588	92	6	two	two	NUM
cusj-5588	92	7	main	main	ADJ
cusj-5588	92	8	developing	develop	VERB
cusj-5588	92	9	therapies	therapy	NOUN
cusj-5588	92	10	examined	examine	VERB
cusj-5588	92	11	,	,	PUNCT
cusj-5588	92	12	gene	gene	NOUN
cusj-5588	92	13	and	and	CCONJ
cusj-5588	92	14	stem	stem	NOUN
cusj-5588	92	15	cell	cell	NOUN
cusj-5588	92	16	therapy	therapy	NOUN
cusj-5588	92	17	,	,	PUNCT
cusj-5588	92	18	specific	specific	ADJ
cusj-5588	92	19	focuses	focus	VERB
cusj-5588	92	20	for	for	ADP
cusj-5588	92	21	research	research	NOUN
cusj-5588	92	22	are	be	AUX
cusj-5588	92	23	suggested	suggest	VERB
cusj-5588	92	24	.	.	PUNCT
cusj-5588	93	1	major	major	ADJ
cusj-5588	93	2	milestones	milestone	NOUN
cusj-5588	93	3	in	in	ADP
cusj-5588	93	4	research	research	NOUN
cusj-5588	93	5	that	that	PRON
cusj-5588	93	6	must	must	AUX
cusj-5588	93	7	1	1	NUM
cusj-5588	93	8	table	table	NOUN
cusj-5588	93	9	1	1	NUM
cusj-5588	93	10	based	base	VERB
cusj-5588	93	11	on	on	ADP
cusj-5588	93	12	:	:	PUNCT
cusj-5588	93	13	http://www.nhs.uk/conditions	http://www.nhs.uk/condition	NOUN
cusj-5588	93	14	;	;	PUNCT
cusj-5588	93	15	http://www.neural.org.uk/store/assets/files/20/original/neuronumbers.pdf	http://www.neural.org.uk/store/assets/files/20/original/neuronumbers.pdf	PROPN
cusj-5588	93	16	;	;	PUNCT
cusj-5588	93	17	be	be	AUX
cusj-5588	93	18	reached	reach	VERB
cusj-5588	93	19	before	before	SCONJ
cusj-5588	93	20	clinical	clinical	ADJ
cusj-5588	93	21	application	application	NOUN
cusj-5588	93	22	begin	begin	VERB
cusj-5588	93	23	with	with	ADP
cusj-5588	93	24	better	well	ADJ
cusj-5588	93	25	understandings	understanding	NOUN
cusj-5588	93	26	of	of	ADP
cusj-5588	93	27	disease	disease	NOUN
cusj-5588	93	28	initiation	initiation	NOUN
cusj-5588	93	29	and	and	CCONJ
cusj-5588	93	30	progression	progression	NOUN
cusj-5588	93	31	.	.	PUNCT
cusj-5588	94	1	molecular	molecular	ADJ
cusj-5588	94	2	pathological	pathological	ADJ
cusj-5588	94	3	classification	classification	NOUN
cusj-5588	94	4	through	through	ADP
cusj-5588	94	5	the	the	DET
cusj-5588	94	6	identification	identification	NOUN
cusj-5588	94	7	of	of	ADP
cusj-5588	94	8	biomarkers	biomarker	NOUN
cusj-5588	94	9	can	can	AUX
cusj-5588	94	10	provide	provide	VERB
cusj-5588	94	11	the	the	DET
cusj-5588	94	12	greatest	great	ADJ
cusj-5588	94	13	cross	cross	ADJ
cusj-5588	94	14	-	-	ADJ
cusj-5588	94	15	methodological	methodological	ADJ
cusj-5588	94	16	benefits	benefit	NOUN
cusj-5588	94	17	in	in	ADP
cusj-5588	94	18	furthering	further	VERB
cusj-5588	94	19	effective	effective	ADJ
cusj-5588	94	20	and	and	CCONJ
cusj-5588	94	21	personalized	personalized	ADJ
cusj-5588	94	22	treatment	treatment	NOUN
cusj-5588	94	23	of	of	ADP
cusj-5588	94	24	nds	nds	PROPN
cusj-5588	94	25	.	.	PUNCT
cusj-5588	95	1	fundamentally	fundamentally	ADV
cusj-5588	95	2	,	,	PUNCT
cusj-5588	95	3	a	a	DET
cusj-5588	95	4	more	more	ADV
cusj-5588	95	5	thorough	thorough	ADJ
cusj-5588	95	6	understanding	understanding	NOUN
cusj-5588	95	7	of	of	ADP
cusj-5588	95	8	underlying	underlie	VERB
cusj-5588	95	9	nd	nd	NOUN
cusj-5588	95	10	pathophysiology	pathophysiology	NOUN
cusj-5588	95	11	can	can	AUX
cusj-5588	95	12	be	be	AUX
cusj-5588	95	13	accomplished	accomplish	VERB
cusj-5588	95	14	through	through	ADP
cusj-5588	95	15	biomarker	biomarker	NOUN
cusj-5588	95	16	identification	identification	NOUN
cusj-5588	95	17	,	,	PUNCT
cusj-5588	95	18	stem	stem	VERB
cusj-5588	95	19	cell	cell	NOUN
cusj-5588	95	20	-	-	PUNCT
cusj-5588	95	21	based	base	VERB
cusj-5588	95	22	disease	disease	NOUN
cusj-5588	95	23	modelling	modelling	NOUN
cusj-5588	95	24	,	,	PUNCT
cusj-5588	95	25	and	and	CCONJ
cusj-5588	95	26	genetic	genetic	ADJ
cusj-5588	95	27	research	research	NOUN
cusj-5588	95	28	.	.	PUNCT
cusj-5588	96	1	combined	combine	VERB
cusj-5588	96	2	,	,	PUNCT
cusj-5588	96	3	this	this	DET
cusj-5588	96	4	knowledge	knowledge	NOUN
cusj-5588	96	5	will	will	AUX
cusj-5588	96	6	help	help	VERB
cusj-5588	96	7	develop	develop	VERB
cusj-5588	96	8	more	more	ADV
cusj-5588	96	9	personalized	personalized	ADJ
cusj-5588	96	10	and	and	CCONJ
cusj-5588	96	11	ultimately	ultimately	ADV
cusj-5588	96	12	more	more	ADV
cusj-5588	96	13	effective	effective	ADJ
cusj-5588	96	14	novel	novel	ADJ
cusj-5588	96	15	therapies	therapy	NOUN
cusj-5588	96	16	for	for	ADP
cusj-5588	96	17	treating	treat	VERB
cusj-5588	96	18	neurodevelopmental	neurodevelopmental	ADJ
cusj-5588	96	19	disorders	disorder	NOUN
cusj-5588	96	20	.	.	PUNCT
cusj-5588	97	1	part	part	NOUN
cusj-5588	97	2	1	1	NUM
cusj-5588	97	3	:	:	PUNCT
cusj-5588	97	4	current	current	ADJ
cusj-5588	97	5	approaches	approach	NOUN
cusj-5588	97	6	:	:	PUNCT
cusj-5588	97	7	disease	disease	NOUN
cusj-5588	97	8	management	management	NOUN
cusj-5588	97	9	current	current	ADJ
cusj-5588	97	10	clinical	clinical	ADJ
cusj-5588	97	11	approaches	approach	NOUN
cusj-5588	97	12	to	to	ADP
cusj-5588	97	13	addressing	address	VERB
cusj-5588	97	14	ad	ad	NOUN
cusj-5588	97	15	,	,	PUNCT
cusj-5588	97	16	pd	pd	NOUN
cusj-5588	97	17	,	,	PUNCT
cusj-5588	97	18	and	and	CCONJ
cusj-5588	97	19	hd	hd	VERB
cusj-5588	97	20	all	all	DET
cusj-5588	97	21	center	center	NOUN
cusj-5588	97	22	on	on	ADP
cusj-5588	97	23	disease	disease	NOUN
cusj-5588	97	24	management	management	NOUN
cusj-5588	97	25	and	and	CCONJ
cusj-5588	97	26	symptom	symptom	NOUN
cusj-5588	97	27	alleviation	alleviation	NOUN
cusj-5588	97	28	.	.	PUNCT
cusj-5588	98	1	the	the	DET
cusj-5588	98	2	use	use	NOUN
cusj-5588	98	3	of	of	ADP
cusj-5588	98	4	pharmacological	pharmacological	ADJ
cusj-5588	98	5	agents	agent	NOUN
cusj-5588	98	6	,	,	PUNCT
cusj-5588	98	7	physical	physical	ADJ
cusj-5588	98	8	therapy	therapy	NOUN
cusj-5588	98	9	,	,	PUNCT
cusj-5588	98	10	and	and	CCONJ
cusj-5588	98	11	caregiving	caregive	VERB
cusj-5588	98	12	aid	aid	NOUN
cusj-5588	98	13	is	be	AUX
cusj-5588	98	14	efficient	efficient	ADJ
cusj-5588	98	15	and	and	CCONJ
cusj-5588	98	16	affordable	affordable	ADJ
cusj-5588	98	17	,	,	PUNCT
cusj-5588	98	18	but	but	CCONJ
cusj-5588	98	19	are	be	AUX
cusj-5588	98	20	ultimately	ultimately	ADV
cusj-5588	98	21	only	only	ADV
cusj-5588	98	22	forms	form	NOUN
cusj-5588	98	23	of	of	ADP
cusj-5588	98	24	palliative	palliative	ADJ
cusj-5588	98	25	care	care	NOUN
cusj-5588	98	26	rather	rather	ADV
cusj-5588	98	27	than	than	ADP
cusj-5588	98	28	effective	effective	ADJ
cusj-5588	98	29	treatments	treatment	NOUN
cusj-5588	98	30	.	.	PUNCT
cusj-5588	99	1	four	four	NUM
cusj-5588	99	2	acetylcholinesterase	acetylcholinesterase	NOUN
cusj-5588	99	3	inhibitors	inhibitor	NOUN
cusj-5588	99	4	(	(	PUNCT
cusj-5588	99	5	donepezil	donepezil	NOUN
cusj-5588	99	6	,	,	PUNCT
cusj-5588	99	7	galantamine	galantamine	NOUN
cusj-5588	99	8	,	,	PUNCT
cusj-5588	99	9	rivastigmine	rivastigmine	NOUN
cusj-5588	99	10	,	,	PUNCT
cusj-5588	99	11	tacrine	tacrine	NOUN
cusj-5588	99	12	)	)	PUNCT
cusj-5588	99	13	and	and	CCONJ
cusj-5588	99	14	one	one	NUM
cusj-5588	99	15	nmda	nmda	ADJ
cusj-5588	99	16	receptor	receptor	NOUN
cusj-5588	99	17	antagonist	antagonist	NOUN
cusj-5588	99	18	(	(	PUNCT
cusj-5588	99	19	memantine	memantine	NOUN
cusj-5588	99	20	)	)	PUNCT
cusj-5588	99	21	constitute	constitute	VERB
cusj-5588	99	22	the	the	DET
cusj-5588	99	23	five	five	NUM
cusj-5588	99	24	main	main	ADJ
cusj-5588	99	25	medications	medication	NOUN
cusj-5588	99	26	currently	currently	ADV
cusj-5588	99	27	used	use	VERB
cusj-5588	99	28	to	to	PART
cusj-5588	99	29	provide	provide	VERB
cusj-5588	99	30	temporary	temporary	ADJ
cusj-5588	99	31	symptomatic	symptomatic	ADJ
cusj-5588	99	32	relief	relief	NOUN
cusj-5588	99	33	to	to	ADP
cusj-5588	99	34	ad	ad	NOUN
cusj-5588	99	35	patients	patient	NOUN
cusj-5588	99	36	(	(	PUNCT
cusj-5588	99	37	desai	desai	PROPN
cusj-5588	99	38	&	&	CCONJ
cusj-5588	99	39	grossberg	grossberg	PROPN
cusj-5588	99	40	,	,	PUNCT
cusj-5588	99	41	2005	2005	NUM
cusj-5588	99	42	)	)	PUNCT
cusj-5588	99	43	.	.	PUNCT
cusj-5588	100	1	the	the	DET
cusj-5588	100	2	first	first	ADJ
cusj-5588	100	3	four	four	NUM
cusj-5588	100	4	enhance	enhance	NOUN
cusj-5588	100	5	cholinergic	cholinergic	ADJ
cusj-5588	100	6	function	function	NOUN
cusj-5588	100	7	by	by	ADP
cusj-5588	100	8	reducing	reduce	VERB
cusj-5588	100	9	rates	rate	NOUN
cusj-5588	100	10	of	of	ADP
cusj-5588	100	11	acetylcholine	acetylcholine	ADJ
cusj-5588	100	12	breakdown	breakdown	NOUN
cusj-5588	100	13	(	(	PUNCT
cusj-5588	100	14	as	as	SCONJ
cusj-5588	100	15	reduced	reduce	VERB
cusj-5588	100	16	ach	ach	NOUN
cusj-5588	100	17	levels	level	NOUN
cusj-5588	100	18	is	be	AUX
cusj-5588	100	19	related	relate	VERB
cusj-5588	100	20	to	to	ADP
cusj-5588	100	21	memory	memory	NOUN
cusj-5588	100	22	and	and	CCONJ
cusj-5588	100	23	cognitive	cognitive	ADJ
cusj-5588	100	24	decline	decline	NOUN
cusj-5588	100	25	in	in	ADP
cusj-5588	100	26	ad	ad	NOUN
cusj-5588	100	27	)	)	PUNCT
cusj-5588	100	28	,	,	PUNCT
cusj-5588	100	29	while	while	SCONJ
cusj-5588	100	30	memantine	memantine	NOUN
cusj-5588	100	31	reduces	reduce	VERB
cusj-5588	100	32	adrelated	adrelate	VERB
cusj-5588	100	33	excitotoxicity	excitotoxicity	NOUN
cusj-5588	100	34	(	(	PUNCT
cusj-5588	100	35	observed	observe	VERB
cusj-5588	100	36	in	in	ADP
cusj-5588	100	37	ad	ad	NOUN
cusj-5588	100	38	&	&	CCONJ
cusj-5588	100	39	related	relate	VERB
cusj-5588	100	40	to	to	ADP
cusj-5588	100	41	neuronal	neuronal	ADJ
cusj-5588	100	42	death	death	NOUN
cusj-5588	100	43	)	)	PUNCT
cusj-5588	100	44	.	.	PUNCT
cusj-5588	101	1	further	far	ADV
cusj-5588	101	2	behavioural	behavioural	ADJ
cusj-5588	101	3	,	,	PUNCT
cusj-5588	101	4	psychosocial	psychosocial	ADJ
cusj-5588	101	5	,	,	PUNCT
cusj-5588	101	6	and	and	CCONJ
cusj-5588	101	7	caregiving	caregive	VERB
cusj-5588	101	8	provisions	provision	NOUN
cusj-5588	101	9	are	be	AUX
cusj-5588	101	10	used	use	VERB
cusj-5588	101	11	to	to	PART
cusj-5588	101	12	improve	improve	VERB
cusj-5588	101	13	quality	quality	NOUN
cusj-5588	101	14	of	of	ADP
cusj-5588	101	15	life	life	NOUN
cusj-5588	101	16	for	for	ADP
cusj-5588	101	17	ad	ad	NOUN
cusj-5588	101	18	patients	patient	NOUN
cusj-5588	101	19	.	.	PUNCT
cusj-5588	102	1	current	current	ADJ
cusj-5588	102	2	therapies	therapy	NOUN
cusj-5588	102	3	for	for	ADP
cusj-5588	102	4	pd	pd	PROPN
cusj-5588	102	5	are	be	AUX
cusj-5588	102	6	arguably	arguably	ADV
cusj-5588	102	7	the	the	DET
cusj-5588	102	8	most	most	ADV
cusj-5588	102	9	welldeveloped	welldevelope	VERB
cusj-5588	102	10	and	and	CCONJ
cusj-5588	102	11	effective	effective	ADJ
cusj-5588	102	12	among	among	ADP
cusj-5588	102	13	these	these	DET
cusj-5588	102	14	three	three	NUM
cusj-5588	102	15	discussed	discuss	VERB
cusj-5588	102	16	nds	nd	NOUN
cusj-5588	102	17	.	.	PUNCT
cusj-5588	103	1	drugs	drug	NOUN
cusj-5588	103	2	such	such	ADJ
cusj-5588	103	3	as	as	ADP
cusj-5588	103	4	levodopa	levodopa	NOUN
cusj-5588	103	5	or	or	CCONJ
cusj-5588	103	6	dopamine	dopamine	NOUN
cusj-5588	103	7	agonists	agonist	NOUN
cusj-5588	103	8	used	use	VERB
cusj-5588	103	9	in	in	ADP
cusj-5588	103	10	earlier	early	ADJ
cusj-5588	103	11	stages	stage	NOUN
cusj-5588	103	12	of	of	ADP
cusj-5588	103	13	care	care	NOUN
cusj-5588	103	14	can	can	AUX
cusj-5588	103	15	restore	restore	VERB
cusj-5588	103	16	some	some	DET
cusj-5588	103	17	motor	motor	NOUN
cusj-5588	103	18	function	function	NOUN
cusj-5588	103	19	,	,	PUNCT
cusj-5588	103	20	but	but	CCONJ
cusj-5588	103	21	their	their	PRON
cusj-5588	103	22	efficacy	efficacy	NOUN
cusj-5588	103	23	decreases	decrease	VERB
cusj-5588	103	24	dramatically	dramatically	ADV
cusj-5588	103	25	over	over	ADP
cusj-5588	103	26	time	time	NOUN
cusj-5588	103	27	.	.	PUNCT
cusj-5588	104	1	deep	deep	ADJ
cusj-5588	104	2	brain	brain	NOUN
cusj-5588	104	3	stimulation	stimulation	NOUN
cusj-5588	104	4	(	(	PUNCT
cusj-5588	104	5	dbs	dbs	PROPN
cusj-5588	104	6	)	)	PUNCT
cusj-5588	104	7	and	and	CCONJ
cusj-5588	104	8	rehabilitation	rehabilitation	NOUN
cusj-5588	104	9	techniques	technique	NOUN
cusj-5588	104	10	provide	provide	VERB
cusj-5588	104	11	further	further	ADJ
cusj-5588	104	12	symptomatic	symptomatic	ADJ
cusj-5588	104	13	therapies	therapy	NOUN
cusj-5588	104	14	for	for	ADP
cusj-5588	104	15	pd	pd	PROPN
cusj-5588	104	16	(	(	PUNCT
cusj-5588	104	17	mizuno	mizuno	PROPN
cusj-5588	104	18	,	,	PUNCT
cusj-5588	104	19	2014	2014	NUM
cusj-5588	104	20	)	)	PUNCT
cusj-5588	104	21	.	.	PUNCT
cusj-5588	105	1	treatments	treatment	NOUN
cusj-5588	105	2	for	for	ADP
cusj-5588	105	3	hd	hd	NOUN
cusj-5588	105	4	,	,	PUNCT
cusj-5588	105	5	like	like	ADP
cusj-5588	105	6	those	those	PRON
cusj-5588	105	7	for	for	ADP
cusj-5588	105	8	ad	ad	NOUN
cusj-5588	105	9	and	and	CCONJ
cusj-5588	105	10	pd	pd	NOUN
cusj-5588	105	11	,	,	PUNCT
cusj-5588	105	12	are	be	AUX
cusj-5588	105	13	only	only	ADV
cusj-5588	105	14	able	able	ADJ
cusj-5588	105	15	to	to	PART
cusj-5588	105	16	reduce	reduce	VERB
cusj-5588	105	17	symptom	symptom	NOUN
cusj-5588	105	18	severity	severity	NOUN
cusj-5588	105	19	.	.	PUNCT
cusj-5588	106	1	various	various	ADJ
cusj-5588	106	2	pharmacological	pharmacological	ADJ
cusj-5588	106	3	treatments	treatment	NOUN
cusj-5588	106	4	are	be	AUX
cusj-5588	106	5	available	available	ADJ
cusj-5588	106	6	to	to	PART
cusj-5588	106	7	reduce	reduce	VERB
cusj-5588	106	8	chorea	chorea	NOUN
cusj-5588	106	9	.	.	PUNCT
cusj-5588	107	1	as	as	SCONJ
cusj-5588	107	2	the	the	DET
cusj-5588	107	3	disease	disease	NOUN
cusj-5588	107	4	progresses	progress	VERB
cusj-5588	107	5	,	,	PUNCT
cusj-5588	107	6	physical	physical	ADJ
cusj-5588	107	7	,	,	PUNCT
cusj-5588	107	8	speech	speech	NOUN
cusj-5588	107	9	,	,	PUNCT
cusj-5588	107	10	and	and	CCONJ
cusj-5588	107	11	language	language	NOUN
cusj-5588	107	12	therapies	therapy	NOUN
cusj-5588	107	13	are	be	AUX
cusj-5588	107	14	used	use	VERB
cusj-5588	107	15	to	to	PART
cusj-5588	107	16	rehabilitate	rehabilitate	VERB
cusj-5588	107	17	physical	physical	ADJ
cusj-5588	107	18	and	and	CCONJ
cusj-5588	107	19	cognitive	cognitive	ADJ
cusj-5588	107	20	function	function	NOUN
cusj-5588	107	21	(	(	PUNCT
cusj-5588	107	22	busse	busse	PROPN
cusj-5588	107	23	et	et	PROPN
cusj-5588	107	24	al	al	PROPN
cusj-5588	107	25	.	.	PROPN
cusj-5588	107	26	,	,	PUNCT
cusj-5588	107	27	2012	2012	NUM
cusj-5588	107	28	)	)	PUNCT
cusj-5588	107	29	.	.	PUNCT
cusj-5588	108	1	https://www.ncbi.nlm.nih.gov/books/nbk1352/	https://www.ncbi.nlm.nih.gov/books/nbk1352/	NOUN
cusj-5588	108	2	;	;	PUNCT
cusj-5588	108	3	https://neurodiscovery.harvard.edu/challenge	https://neurodiscovery.harvard.edu/challenge	NOUN
cusj-5588	108	4	treating	treat	VERB
cusj-5588	108	5	neurodegenerative	neurodegenerative	ADJ
cusj-5588	108	6	disorders	disorder	NOUN
cusj-5588	108	7	:	:	PUNCT
cusj-5588	108	8	towards	towards	ADP
cusj-5588	108	9	detailed	detailed	ADJ
cusj-5588	108	10	pathophysiology	pathophysiology	NOUN
cusj-5588	108	11	and	and	CCONJ
cusj-5588	108	12	precision	precision	NOUN
cusj-5588	108	13	medicine	medicine	NOUN
cusj-5588	108	14	katie	katie	PROPN
cusj-5588	108	15	gu	gu	PROPN
cusj-5588	108	16	stanford	stanford	PROPN
cusj-5588	108	17	university	university	PROPN
cusj-5588	108	18	10	10	NUM
cusj-5588	108	19	_	_	PUNCT
cusj-5588	109	1	_	_	PUNCT
cusj-5588	110	1	_	_	PUNCT
cusj-5588	111	1	_	_	PUNCT
cusj-5588	112	1	_	_	PUNCT
cusj-5588	113	1	_	_	PUNCT
cusj-5588	114	1	_	_	PUNCT
cusj-5588	115	1	_	_	PUNCT
cusj-5588	116	1	_	_	PUNCT
cusj-5588	117	1	_	_	PUNCT
cusj-5588	118	1	_	_	PUNCT
cusj-5588	119	1	_	_	PUNCT
cusj-5588	120	1	_	_	PUNCT
cusj-5588	121	1	_	_	PUNCT
cusj-5588	122	1	_	_	PUNCT
cusj-5588	123	1	_	_	PUNCT
cusj-5588	124	1	_	_	PUNCT
cusj-5588	125	1	_	_	PUNCT
cusj-5588	126	1	_	_	PUNCT
cusj-5588	127	1	_	_	PUNCT
cusj-5588	128	1	_	_	PUNCT
cusj-5588	129	1	_	_	PUNCT
cusj-5588	130	1	_	_	PUNCT
cusj-5588	131	1	_	_	PUNCT
cusj-5588	132	1	_	_	PUNCT
cusj-5588	133	1	_	_	PUNCT
cusj-5588	134	1	_	_	PUNCT
cusj-5588	135	1	_	_	PUNCT
cusj-5588	136	1	_	_	PUNCT
cusj-5588	137	1	_	_	PUNCT
cusj-5588	138	1	_	_	PUNCT
cusj-5588	139	1	_	_	PUNCT
cusj-5588	140	1	_	_	PUNCT
cusj-5588	141	1	_	_	PUNCT
cusj-5588	142	1	_	_	PUNCT
cusj-5588	143	1	_	_	PUNCT
cusj-5588	144	1	_	_	PUNCT
cusj-5588	145	1	_	_	PUNCT
cusj-5588	146	1	_	_	PUNCT
cusj-5588	147	1	_	_	PUNCT
cusj-5588	148	1	_	_	PUNCT
cusj-5588	149	1	_	_	PUNCT
cusj-5588	150	1	_	_	PUNCT
cusj-5588	151	1	_	_	PUNCT
cusj-5588	152	1	_	_	PUNCT
cusj-5588	153	1	_	_	PUNCT
cusj-5588	154	1	_	_	PUNCT
cusj-5588	155	1	_	_	PUNCT
cusj-5588	156	1	_	_	PUNCT
cusj-5588	157	1	_	_	PUNCT
cusj-5588	158	1	_	_	PUNCT
cusj-5588	159	1	_	_	PUNCT
cusj-5588	160	1	_	_	PUNCT
cusj-5588	161	1	_	_	PUNCT
cusj-5588	162	1	_	_	PUNCT
cusj-5588	163	1	_	_	PUNCT
cusj-5588	164	1	_	_	PUNCT
cusj-5588	165	1	_	_	PUNCT
cusj-5588	166	1	_	_	PUNCT
cusj-5588	167	1	_	_	PUNCT
cusj-5588	168	1	_	_	PUNCT
cusj-5588	169	1	_	_	PUNCT
cusj-5588	170	1	_	_	PUNCT
cusj-5588	171	1	_	_	PUNCT
cusj-5588	172	1	_	_	PUNCT
cusj-5588	173	1	_	_	PUNCT
cusj-5588	174	1	_	_	PUNCT
cusj-5588	175	1	_	_	PUNCT
cusj-5588	176	1	_	_	PUNCT
cusj-5588	177	1	_	_	PUNCT
cusj-5588	178	1	_	_	PUNCT
cusj-5588	179	1	_	_	PUNCT
cusj-5588	180	1	_	_	PUNCT
cusj-5588	181	1	_	_	PUNCT
cusj-5588	182	1	_	_	PUNCT
cusj-5588	183	1	_	_	PUNCT
cusj-5588	184	1	_	_	PUNCT
cusj-5588	185	1	_	_	PUNCT
cusj-5588	186	1	_	_	PUNCT
cusj-5588	187	1	_	_	PUNCT
cusj-5588	187	2	cusj	cusj	VERB
cusj-5588	187	3	2018	2018	NUM
cusj-5588	187	4	gaps	gap	NOUN
cusj-5588	187	5	in	in	ADP
cusj-5588	187	6	current	current	ADJ
cusj-5588	187	7	treatment	treatment	NOUN
cusj-5588	187	8	techniques	technique	NOUN
cusj-5588	187	9	techniques	technique	NOUN
cusj-5588	187	10	currently	currently	ADV
cusj-5588	187	11	available	available	ADJ
cusj-5588	187	12	to	to	PART
cusj-5588	187	13	treat	treat	VERB
cusj-5588	187	14	neurodegenerative	neurodegenerative	ADJ
cusj-5588	187	15	diseases	disease	NOUN
cusj-5588	187	16	are	be	AUX
cusj-5588	187	17	able	able	ADJ
cusj-5588	187	18	to	to	PART
cusj-5588	187	19	provide	provide	VERB
cusj-5588	187	20	temporary	temporary	ADJ
cusj-5588	187	21	symptomatic	symptomatic	ADJ
cusj-5588	187	22	relief	relief	NOUN
cusj-5588	187	23	,	,	PUNCT
cusj-5588	187	24	but	but	CCONJ
cusj-5588	187	25	are	be	AUX
cusj-5588	187	26	critically	critically	ADV
cusj-5588	187	27	unable	unable	ADJ
cusj-5588	187	28	to	to	PART
cusj-5588	187	29	halt	halt	VERB
cusj-5588	187	30	the	the	DET
cusj-5588	187	31	rapid	rapid	ADJ
cusj-5588	187	32	deterioration	deterioration	NOUN
cusj-5588	187	33	and	and	CCONJ
cusj-5588	187	34	progression	progression	NOUN
cusj-5588	187	35	of	of	ADP
cusj-5588	187	36	neurodegeneration	neurodegeneration	NOUN
cusj-5588	187	37	.	.	PUNCT
cusj-5588	188	1	though	though	SCONJ
cusj-5588	188	2	the	the	DET
cusj-5588	188	3	complete	complete	ADJ
cusj-5588	188	4	causes	cause	NOUN
cusj-5588	188	5	of	of	ADP
cusj-5588	188	6	ad	ad	NOUN
cusj-5588	188	7	and	and	CCONJ
cusj-5588	188	8	pd	pd	NOUN
cusj-5588	188	9	have	have	AUX
cusj-5588	188	10	not	not	PART
cusj-5588	188	11	been	be	AUX
cusj-5588	188	12	fully	fully	ADV
cusj-5588	188	13	characterised	characterise	VERB
cusj-5588	188	14	,	,	PUNCT
cusj-5588	188	15	neurofibrillary	neurofibrillary	ADJ
cusj-5588	188	16	tangles	tangle	NOUN
cusj-5588	188	17	,	,	PUNCT
cusj-5588	188	18	-amyloid	-amyloid	NOUN
cusj-5588	188	19	plaques	plaque	NOUN
cusj-5588	188	20	,	,	PUNCT
cusj-5588	188	21	decreased	decrease	VERB
cusj-5588	188	22	synaptic	synaptic	ADJ
cusj-5588	188	23	function	function	NOUN
cusj-5588	188	24	,	,	PUNCT
cusj-5588	188	25	and	and	CCONJ
cusj-5588	188	26	cortical	cortical	ADJ
cusj-5588	188	27	atrophy	atrophy	NOUN
cusj-5588	188	28	observed	observe	VERB
cusj-5588	188	29	in	in	ADP
cusj-5588	188	30	ad	ad	NOUN
cusj-5588	188	31	and	and	CCONJ
cusj-5588	188	32	the	the	DET
cusj-5588	188	33	loss	loss	NOUN
cusj-5588	188	34	of	of	ADP
cusj-5588	188	35	dopaminergic	dopaminergic	ADJ
cusj-5588	188	36	neurons	neuron	NOUN
cusj-5588	188	37	characteristic	characteristic	ADJ
cusj-5588	188	38	of	of	ADP
cusj-5588	188	39	pd	pd	PROPN
cusj-5588	188	40	can	can	AUX
cusj-5588	188	41	be	be	AUX
cusj-5588	188	42	addressed	address	VERB
cusj-5588	188	43	by	by	ADP
cusj-5588	188	44	gene	gene	NOUN
cusj-5588	188	45	therapy	therapy	NOUN
cusj-5588	188	46	and	and	CCONJ
cusj-5588	188	47	stem	stem	VERB
cusj-5588	188	48	cell	cell	NOUN
cusj-5588	188	49	-	-	PUNCT
cusj-5588	188	50	based	base	VERB
cusj-5588	188	51	therapies	therapy	NOUN
cusj-5588	188	52	.	.	PUNCT
cusj-5588	189	1	these	these	DET
cusj-5588	189	2	two	two	NUM
cusj-5588	189	3	therapies	therapy	NOUN
cusj-5588	189	4	can	can	AUX
cusj-5588	189	5	also	also	ADV
cusj-5588	189	6	be	be	AUX
cusj-5588	189	7	applied	apply	VERB
cusj-5588	189	8	to	to	PART
cusj-5588	189	9	treat	treat	VERB
cusj-5588	189	10	the	the	DET
cusj-5588	189	11	root	root	NOUN
cusj-5588	189	12	causes	cause	NOUN
cusj-5588	189	13	of	of	ADP
cusj-5588	189	14	hd	hd	NOUN
cusj-5588	189	15	,	,	PUNCT
cusj-5588	189	16	which	which	PRON
cusj-5588	189	17	has	have	AUX
cusj-5588	189	18	been	be	AUX
cusj-5588	189	19	attributed	attribute	VERB
cusj-5588	189	20	to	to	ADP
cusj-5588	189	21	an	an	DET
cusj-5588	189	22	expanded	expand	VERB
cusj-5588	189	23	trinucleotide	trinucleotide	NOUN
cusj-5588	189	24	repeats	repeat	NOUN
cusj-5588	189	25	,	,	PUNCT
cusj-5588	189	26	the	the	DET
cusj-5588	189	27	mhtt	mhtt	PROPN
cusj-5588	189	28	protein	protein	NOUN
cusj-5588	189	29	,	,	PUNCT
cusj-5588	189	30	and	and	CCONJ
cusj-5588	189	31	consequent	consequent	ADJ
cusj-5588	189	32	neostriatal	neostriatal	ADJ
cusj-5588	189	33	neuronal	neuronal	ADJ
cusj-5588	189	34	loss	loss	NOUN
cusj-5588	189	35	.	.	PUNCT
cusj-5588	190	1	however	however	ADV
cusj-5588	190	2	,	,	PUNCT
cusj-5588	190	3	their	their	PRON
cusj-5588	190	4	widespread	widespread	ADJ
cusj-5588	190	5	clinical	clinical	ADJ
cusj-5588	190	6	application	application	NOUN
cusj-5588	190	7	has	have	AUX
cusj-5588	190	8	been	be	AUX
cusj-5588	190	9	limited	limit	VERB
cusj-5588	190	10	by	by	ADP
cusj-5588	190	11	underdeveloped	underdeveloped	ADJ
cusj-5588	190	12	understandings	understanding	NOUN
cusj-5588	190	13	of	of	ADP
cusj-5588	190	14	disease	disease	NOUN
cusj-5588	190	15	etiology	etiology	NOUN
cusj-5588	190	16	and	and	CCONJ
cusj-5588	190	17	mechanisms	mechanism	NOUN
cusj-5588	190	18	of	of	ADP
cusj-5588	190	19	therapeutic	therapeutic	ADJ
cusj-5588	190	20	action	action	NOUN
cusj-5588	190	21	.	.	PUNCT
cusj-5588	191	1	insights	insight	NOUN
cusj-5588	191	2	into	into	ADP
cusj-5588	191	3	the	the	DET
cusj-5588	191	4	molecular	molecular	ADJ
cusj-5588	191	5	mechanisms	mechanism	NOUN
cusj-5588	191	6	of	of	ADP
cusj-5588	191	7	nds	nd	NOUN
cusj-5588	191	8	lie	lie	VERB
cusj-5588	191	9	at	at	ADP
cusj-5588	191	10	the	the	DET
cusj-5588	191	11	crux	crux	NOUN
cusj-5588	191	12	for	for	ADP
cusj-5588	191	13	the	the	DET
cusj-5588	191	14	development	development	NOUN
cusj-5588	191	15	of	of	ADP
cusj-5588	191	16	novel	novel	ADJ
cusj-5588	191	17	targets	target	NOUN
cusj-5588	191	18	of	of	ADP
cusj-5588	191	19	disease	disease	NOUN
cusj-5588	191	20	-	-	PUNCT
cusj-5588	191	21	modifying	modify	VERB
cusj-5588	191	22	therapies	therapy	NOUN
cusj-5588	191	23	.	.	PUNCT
cusj-5588	192	1	therefore	therefore	ADV
cusj-5588	192	2	,	,	PUNCT
cusj-5588	192	3	efforts	effort	NOUN
cusj-5588	192	4	to	to	PART
cusj-5588	192	5	further	further	ADJ
cusj-5588	192	6	gene	gene	VERB
cusj-5588	192	7	and	and	CCONJ
cusj-5588	192	8	stem	stem	NOUN
cusj-5588	192	9	cellbased	cellbase	VERB
cusj-5588	192	10	therapies	therapy	NOUN
cusj-5588	192	11	(	(	PUNCT
cusj-5588	192	12	discussed	discuss	VERB
cusj-5588	192	13	in	in	ADP
cusj-5588	192	14	parts	part	NOUN
cusj-5588	192	15	2	2	NUM
cusj-5588	192	16	&	&	CCONJ
cusj-5588	192	17	3	3	NUM
cusj-5588	192	18	)	)	PUNCT
cusj-5588	192	19	will	will	AUX
cusj-5588	192	20	benefit	benefit	VERB
cusj-5588	192	21	from	from	ADP
cusj-5588	192	22	an	an	DET
cusj-5588	192	23	increased	increase	VERB
cusj-5588	192	24	focus	focus	NOUN
cusj-5588	192	25	on	on	ADP
cusj-5588	192	26	biomarker	biomarker	NOUN
cusj-5588	192	27	research	research	NOUN
cusj-5588	192	28	(	(	PUNCT
cusj-5588	192	29	discussed	discuss	VERB
cusj-5588	192	30	in	in	ADP
cusj-5588	192	31	part	part	NOUN
cusj-5588	192	32	4	4	NUM
cusj-5588	192	33	)	)	PUNCT
cusj-5588	192	34	to	to	PART
cusj-5588	192	35	elucidate	elucidate	VERB
cusj-5588	192	36	disease	disease	NOUN
cusj-5588	192	37	pathophysiologies	pathophysiologie	NOUN
cusj-5588	192	38	.	.	PUNCT
cusj-5588	193	1	part	part	NOUN
cusj-5588	193	2	2	2	NUM
cusj-5588	193	3	:	:	PUNCT
cusj-5588	193	4	gene	gene	NOUN
cusj-5588	193	5	therapy2	therapy2	NOUN
cusj-5588	193	6	the	the	DET
cusj-5588	193	7	theory	theory	NOUN
cusj-5588	193	8	behind	behind	ADP
cusj-5588	193	9	the	the	DET
cusj-5588	193	10	use	use	NOUN
cusj-5588	193	11	of	of	ADP
cusj-5588	193	12	gene	gene	NOUN
cusj-5588	193	13	therapy	therapy	NOUN
cusj-5588	193	14	to	to	PART
cusj-5588	193	15	treat	treat	VERB
cusj-5588	193	16	neurodegenerative	neurodegenerative	ADJ
cusj-5588	193	17	disease	disease	NOUN
cusj-5588	193	18	is	be	AUX
cusj-5588	193	19	simple	simple	ADJ
cusj-5588	193	20	:	:	PUNCT
cusj-5588	193	21	deliver	deliver	VERB
cusj-5588	193	22	a	a	DET
cusj-5588	193	23	transgene	transgene	NOUN
cusj-5588	193	24	that	that	SCONJ
cusj-5588	193	25	either	either	CCONJ
cusj-5588	193	26	corrects	correct	NOUN
cusj-5588	193	27	or	or	CCONJ
cusj-5588	193	28	replaces	replace	VERB
cusj-5588	193	29	a	a	DET
cusj-5588	193	30	defective	defective	ADJ
cusj-5588	193	31	gene	gene	NOUN
cusj-5588	193	32	to	to	PART
cusj-5588	193	33	cure	cure	VERB
cusj-5588	193	34	a	a	DET
cusj-5588	193	35	complex	complex	ADJ
cusj-5588	193	36	disease	disease	NOUN
cusj-5588	193	37	using	use	VERB
cusj-5588	193	38	a	a	DET
cusj-5588	193	39	transfer	transfer	NOUN
cusj-5588	193	40	vector	vector	NOUN
cusj-5588	193	41	.	.	PUNCT
cusj-5588	194	1	however	however	ADV
cusj-5588	194	2	,	,	PUNCT
cusj-5588	194	3	the	the	DET
cusj-5588	194	4	numerous	numerous	ADJ
cusj-5588	194	5	technical	technical	ADJ
cusj-5588	194	6	difficulties	difficulty	NOUN
cusj-5588	194	7	associated	associate	VERB
cusj-5588	194	8	with	with	ADP
cusj-5588	194	9	gene	gene	NOUN
cusj-5588	194	10	therapy	therapy	NOUN
cusj-5588	194	11	are	be	AUX
cusj-5588	194	12	daunting	daunt	VERB
cusj-5588	194	13	in	in	ADP
cusj-5588	194	14	complexity	complexity	NOUN
cusj-5588	194	15	:	:	PUNCT
cusj-5588	194	16	the	the	DET
cusj-5588	194	17	transfer	transfer	NOUN
cusj-5588	194	18	vector	vector	NOUN
cusj-5588	194	19	must	must	AUX
cusj-5588	194	20	be	be	AUX
cusj-5588	194	21	easy	easy	ADJ
cusj-5588	194	22	to	to	PART
cusj-5588	194	23	produce	produce	VERB
cusj-5588	194	24	,	,	PUNCT
cusj-5588	194	25	safe	safe	ADJ
cusj-5588	194	26	for	for	ADP
cusj-5588	194	27	patients	patient	NOUN
cusj-5588	194	28	and	and	CCONJ
cusj-5588	194	29	the	the	DET
cusj-5588	194	30	environment	environment	NOUN
cusj-5588	194	31	,	,	PUNCT
cusj-5588	194	32	target	target	VERB
cusj-5588	194	33	specific	specific	ADJ
cusj-5588	194	34	cells	cell	NOUN
cusj-5588	194	35	efficiently	efficiently	ADV
cusj-5588	194	36	,	,	PUNCT
cusj-5588	194	37	and	and	CCONJ
cusj-5588	194	38	not	not	PART
cusj-5588	194	39	trigger	trigger	VERB
cusj-5588	194	40	a	a	DET
cusj-5588	194	41	deleterious	deleterious	ADJ
cusj-5588	194	42	immune	immune	ADJ
cusj-5588	194	43	reaction	reaction	NOUN
cusj-5588	194	44	;	;	PUNCT
cusj-5588	194	45	simultaneously	simultaneously	ADV
cusj-5588	194	46	,	,	PUNCT
cusj-5588	194	47	the	the	DET
cusj-5588	194	48	appropriate	appropriate	ADJ
cusj-5588	194	49	transduced	transduce	VERB
cusj-5588	194	50	transgene	transgene	NOUN
cusj-5588	194	51	must	must	AUX
cusj-5588	194	52	be	be	AUX
cusj-5588	194	53	expressed	express	VERB
cusj-5588	194	54	at	at	ADP
cusj-5588	194	55	the	the	DET
cusj-5588	194	56	optimal	optimal	ADJ
cusj-5588	194	57	level	level	NOUN
cusj-5588	194	58	for	for	ADP
cusj-5588	194	59	an	an	DET
cusj-5588	194	60	optimal	optimal	ADJ
cusj-5588	194	61	duration	duration	NOUN
cusj-5588	194	62	(	(	PUNCT
cusj-5588	194	63	sarkis	sarkis	PROPN
cusj-5588	194	64	&	&	CCONJ
cusj-5588	194	65	mallet	mallet	PROPN
cusj-5588	194	66	,	,	PUNCT
cusj-5588	194	67	2005	2005	NUM
cusj-5588	194	68	)	)	PUNCT
cusj-5588	194	69	.	.	PUNCT
cusj-5588	195	1	all	all	DET
cusj-5588	195	2	these	these	DET
cusj-5588	195	3	factors	factor	NOUN
cusj-5588	195	4	that	that	PRON
cusj-5588	195	5	must	must	AUX
cusj-5588	195	6	be	be	AUX
cusj-5588	195	7	taken	take	VERB
cusj-5588	195	8	into	into	ADP
cusj-5588	195	9	consideration	consideration	NOUN
cusj-5588	195	10	can	can	AUX
cusj-5588	195	11	only	only	ADV
cusj-5588	195	12	be	be	AUX
cusj-5588	195	13	optimized	optimize	VERB
cusj-5588	195	14	with	with	ADP
cusj-5588	195	15	increased	increase	VERB
cusj-5588	195	16	knowledge	knowledge	NOUN
cusj-5588	195	17	of	of	ADP
cusj-5588	195	18	disease	disease	NOUN
cusj-5588	195	19	etiology	etiology	NOUN
cusj-5588	195	20	,	,	PUNCT
cusj-5588	195	21	which	which	PRON
cusj-5588	195	22	can	can	AUX
cusj-5588	195	23	be	be	AUX
cusj-5588	195	24	mediated	mediate	VERB
cusj-5588	195	25	through	through	ADP
cusj-5588	195	26	biomarker	biomarker	NOUN
cusj-5588	195	27	research	research	NOUN
cusj-5588	195	28	.	.	PUNCT
cusj-5588	196	1	gene	gene	NOUN
cusj-5588	196	2	therapy	therapy	NOUN
cusj-5588	196	3	trials	trial	NOUN
cusj-5588	196	4	gene	gene	NOUN
cusj-5588	196	5	therapy	therapy	NOUN
cusj-5588	196	6	vectors	vector	NOUN
cusj-5588	196	7	are	be	AUX
cusj-5588	196	8	either	either	CCONJ
cusj-5588	196	9	viral	viral	ADJ
cusj-5588	196	10	or	or	CCONJ
cusj-5588	196	11	non	non	ADJ
cusj-5588	196	12	-	-	ADJ
cusj-5588	196	13	viral	viral	ADJ
cusj-5588	196	14	.	.	PUNCT
cusj-5588	197	1	currently	currently	ADV
cusj-5588	197	2	,	,	PUNCT
cusj-5588	197	3	the	the	DET
cusj-5588	197	4	most	most	ADV
cusj-5588	197	5	common	common	ADJ
cusj-5588	197	6	viral	viral	ADJ
cusj-5588	197	7	vectors	vector	NOUN
cusj-5588	197	8	are	be	AUX
cusj-5588	197	9	adeno	adeno	NOUN
cusj-5588	197	10	-	-	PUNCT
cusj-5588	197	11	associated	associate	VERB
cusj-5588	197	12	viruses	virus	NOUN
cusj-5588	197	13	(	(	PUNCT
cusj-5588	197	14	aavs	aavs	ADV
cusj-5588	197	15	)	)	PUNCT
cusj-5588	197	16	and	and	CCONJ
cusj-5588	197	17	lentiviruses	lentiviruse	NOUN
cusj-5588	197	18	.	.	PUNCT
cusj-5588	198	1	both	both	PRON
cusj-5588	198	2	infect	infect	VERB
cusj-5588	198	3	non	non	ADJ
cusj-5588	198	4	-	-	ADJ
cusj-5588	198	5	dividing	dividing	ADJ
cusj-5588	198	6	and	and	CCONJ
cusj-5588	198	7	dividing	divide	VERB
cusj-5588	198	8	cells	cell	NOUN
cusj-5588	198	9	,	,	PUNCT
cusj-5588	198	10	but	but	CCONJ
cusj-5588	198	11	lentiviral	lentiviral	ADJ
cusj-5588	198	12	vectors	vector	NOUN
cusj-5588	198	13	integrate	integrate	VERB
cusj-5588	198	14	into	into	ADP
cusj-5588	198	15	host	host	NOUN
cusj-5588	198	16	genomes	genome	NOUN
cusj-5588	198	17	while	while	SCONJ
cusj-5588	198	18	aavs	aavs	NOUN
cusj-5588	198	19	do	do	VERB
cusj-5588	198	20	not	not	PART
cusj-5588	198	21	.	.	PUNCT
cusj-5588	199	1	thus	thus	ADV
cusj-5588	199	2	,	,	PUNCT
cusj-5588	199	3	lentivirus	lentivirus	NOUN
cusj-5588	199	4	integration	integration	NOUN
cusj-5588	199	5	can	can	AUX
cusj-5588	199	6	confer	confer	VERB
cusj-5588	199	7	long	long	ADJ
cusj-5588	199	8	-	-	PUNCT
cusj-5588	199	9	term	term	NOUN
cusj-5588	199	10	,	,	PUNCT
cusj-5588	199	11	stable	stable	ADJ
cusj-5588	199	12	transgene	transgene	NOUN
cusj-5588	199	13	expression	expression	NOUN
cusj-5588	199	14	,	,	PUNCT
cusj-5588	199	15	but	but	CCONJ
cusj-5588	199	16	poses	pose	VERB
cusj-5588	199	17	a	a	DET
cusj-5588	199	18	risk	risk	NOUN
cusj-5588	199	19	of	of	ADP
cusj-5588	199	20	integrational	integrational	ADJ
cusj-5588	199	21	mutagenesis	mutagenesis	NOUN
cusj-5588	199	22	.	.	PUNCT
cusj-5588	200	1	non	non	ADJ
cusj-5588	200	2	-	-	ADJ
cusj-5588	200	3	viral	viral	ADJ
cusj-5588	200	4	vectors	vector	NOUN
cusj-5588	200	5	(	(	PUNCT
cusj-5588	200	6	mostly	mostly	ADV
cusj-5588	200	7	used	use	VERB
cusj-5588	200	8	for	for	ADP
cusj-5588	200	9	hd	hd	NOUN
cusj-5588	200	10	treatment	treatment	NOUN
cusj-5588	200	11	)	)	PUNCT
cusj-5588	200	12	have	have	VERB
cusj-5588	200	13	more	more	ADV
cusj-5588	200	14	localized	localized	ADJ
cusj-5588	200	15	effects	effect	NOUN
cusj-5588	200	16	,	,	PUNCT
cusj-5588	200	17	require	require	VERB
cusj-5588	200	18	higher	high	ADJ
cusj-5588	200	19	2	2	NUM
cusj-5588	200	20	this	this	DET
cusj-5588	200	21	section	section	NOUN
cusj-5588	200	22	is	be	AUX
cusj-5588	200	23	based	base	VERB
cusj-5588	200	24	on	on	ADP
cusj-5588	200	25	readings	reading	NOUN
cusj-5588	200	26	from	from	ADP
cusj-5588	200	27	o’connor	o’connor	ADV
cusj-5588	200	28	&	&	CCONJ
cusj-5588	200	29	boulis	boulis	PROPN
cusj-5588	200	30	(	(	PUNCT
cusj-5588	200	31	2015	2015	NUM
cusj-5588	200	32	)	)	PUNCT
cusj-5588	200	33	,	,	PUNCT
cusj-5588	200	34	as	as	SCONJ
cusj-5588	200	35	accredited	accredit	VERB
cusj-5588	200	36	in	in	ADP
cusj-5588	200	37	works	work	NOUN
cusj-5588	200	38	cited	cite	VERB
cusj-5588	200	39	dosage	dosage	NOUN
cusj-5588	200	40	levels	level	NOUN
cusj-5588	200	41	,	,	PUNCT
cusj-5588	200	42	and	and	CCONJ
cusj-5588	200	43	confer	confer	VERB
cusj-5588	200	44	only	only	ADV
cusj-5588	200	45	transient	transient	ADJ
cusj-5588	200	46	gene	gene	NOUN
cusj-5588	200	47	expression	expression	NOUN
cusj-5588	200	48	that	that	PRON
cusj-5588	200	49	is	be	AUX
cusj-5588	200	50	normally	normally	ADV
cusj-5588	200	51	insufficient	insufficient	ADJ
cusj-5588	200	52	to	to	PART
cusj-5588	200	53	fully	fully	ADV
cusj-5588	200	54	treat	treat	VERB
cusj-5588	200	55	chronic	chronic	ADJ
cusj-5588	200	56	nd	nd	NOUN
cusj-5588	200	57	.	.	NOUN
cusj-5588	200	58	viral	viral	ADJ
cusj-5588	200	59	techniques	technique	NOUN
cusj-5588	200	60	a	a	DET
cusj-5588	200	61	series	series	NOUN
cusj-5588	200	62	of	of	ADP
cusj-5588	200	63	viral	viral	ADJ
cusj-5588	200	64	vector	vector	NOUN
cusj-5588	200	65	-	-	PUNCT
cusj-5588	200	66	mediated	mediate	VERB
cusj-5588	200	67	gene	gene	NOUN
cusj-5588	200	68	therapy	therapy	NOUN
cusj-5588	200	69	trials	trial	NOUN
cusj-5588	200	70	has	have	AUX
cusj-5588	200	71	been	be	AUX
cusj-5588	200	72	conducted	conduct	VERB
cusj-5588	200	73	for	for	ADP
cusj-5588	200	74	ad	ad	NOUN
cusj-5588	200	75	and	and	CCONJ
cusj-5588	200	76	pd	pd	NOUN
cusj-5588	200	77	,	,	PUNCT
cusj-5588	200	78	summarized	summarize	VERB
cusj-5588	200	79	in	in	ADP
cusj-5588	200	80	the	the	DET
cusj-5588	200	81	table	table	NOUN
cusj-5588	200	82	below	below	ADV
cusj-5588	200	83	.	.	PUNCT
cusj-5588	201	1	in	in	ADP
cusj-5588	201	2	these	these	DET
cusj-5588	201	3	trials	trial	NOUN
cusj-5588	201	4	,	,	PUNCT
cusj-5588	201	5	aav2	aav2	PROPN
cusj-5588	201	6	-	-	PUNCT
cusj-5588	201	7	mediated	mediate	VERB
cusj-5588	201	8	transgenes	transgene	NOUN
cusj-5588	201	9	were	be	AUX
cusj-5588	201	10	injected	inject	VERB
cusj-5588	201	11	into	into	ADP
cusj-5588	201	12	patients	patient	NOUN
cusj-5588	201	13	’	'	PUNCT
cusj-5588	201	14	brains	brain	NOUN
cusj-5588	201	15	,	,	PUNCT
cusj-5588	201	16	but	but	CCONJ
cusj-5588	201	17	treatment	treatment	NOUN
cusj-5588	201	18	results	result	NOUN
cusj-5588	201	19	either	either	CCONJ
cusj-5588	201	20	fail	fail	VERB
cusj-5588	201	21	to	to	PART
cusj-5588	201	22	meet	meet	VERB
cusj-5588	201	23	or	or	CCONJ
cusj-5588	201	24	achieve	achieve	VERB
cusj-5588	201	25	the	the	DET
cusj-5588	201	26	same	same	ADJ
cusj-5588	201	27	level	level	NOUN
cusj-5588	201	28	of	of	ADP
cusj-5588	201	29	therapeutic	therapeutic	ADJ
cusj-5588	201	30	benefit	benefit	NOUN
cusj-5588	201	31	as	as	ADP
cusj-5588	201	32	current	current	ADJ
cusj-5588	201	33	standards	standard	NOUN
cusj-5588	201	34	of	of	ADP
cusj-5588	201	35	care	care	NOUN
cusj-5588	201	36	.	.	PUNCT
cusj-5588	202	1	it	it	PRON
cusj-5588	202	2	is	be	AUX
cusj-5588	202	3	important	important	ADJ
cusj-5588	202	4	to	to	PART
cusj-5588	202	5	emphasize	emphasize	VERB
cusj-5588	202	6	that	that	SCONJ
cusj-5588	202	7	the	the	DET
cusj-5588	202	8	efficacy	efficacy	NOUN
cusj-5588	202	9	of	of	ADP
cusj-5588	202	10	gene	gene	NOUN
cusj-5588	202	11	therapy	therapy	NOUN
cusj-5588	202	12	depends	depend	VERB
cusj-5588	202	13	critically	critically	ADV
cusj-5588	202	14	on	on	ADP
cusj-5588	202	15	the	the	DET
cusj-5588	202	16	therapeutic	therapeutic	ADJ
cusj-5588	202	17	gene	gene	NOUN
cusj-5588	202	18	delivered	deliver	VERB
cusj-5588	202	19	;	;	PUNCT
cusj-5588	202	20	this	this	PRON
cusj-5588	202	21	can	can	AUX
cusj-5588	202	22	only	only	ADV
cusj-5588	202	23	be	be	AUX
cusj-5588	202	24	improved	improve	VERB
cusj-5588	202	25	by	by	ADP
cusj-5588	202	26	better	well	ADJ
cusj-5588	202	27	understandings	understanding	NOUN
cusj-5588	202	28	of	of	ADP
cusj-5588	202	29	the	the	DET
cusj-5588	202	30	etiology	etiology	NOUN
cusj-5588	202	31	of	of	ADP
cusj-5588	202	32	neurodegenerative	neurodegenerative	ADJ
cusj-5588	202	33	diseases	disease	NOUN
cusj-5588	202	34	.	.	PUNCT
cusj-5588	203	1	non	non	ADJ
cusj-5588	203	2	-	-	ADJ
cusj-5588	203	3	viral	viral	ADJ
cusj-5588	203	4	techniques	technique	NOUN
cusj-5588	203	5	huntington	huntington	PROPN
cusj-5588	203	6	’s	’s	PART
cusj-5588	203	7	is	be	AUX
cusj-5588	203	8	a	a	DET
cusj-5588	203	9	genetically	genetically	ADV
cusj-5588	203	10	acquired	acquire	VERB
cusj-5588	203	11	disease	disease	NOUN
cusj-5588	203	12	with	with	ADP
cusj-5588	203	13	a	a	DET
cusj-5588	203	14	known	know	VERB
cusj-5588	203	15	etiology	etiology	NOUN
cusj-5588	203	16	(	(	PUNCT
cusj-5588	203	17	cag	cag	PROPN
cusj-5588	203	18	repeats	repeat	VERB
cusj-5588	203	19	in	in	ADP
cusj-5588	203	20	the	the	DET
cusj-5588	203	21	iti5	iti5	PROPN
cusj-5588	203	22	huntington	huntington	PROPN
cusj-5588	203	23	gene	gene	PROPN
cusj-5588	203	24	)	)	PUNCT
cusj-5588	203	25	,	,	PUNCT
cusj-5588	203	26	for	for	ADP
cusj-5588	203	27	which	which	PRON
cusj-5588	203	28	non	non	ADJ
cusj-5588	203	29	-	-	ADJ
cusj-5588	203	30	viral	viral	ADJ
cusj-5588	203	31	gene	gene	NOUN
cusj-5588	203	32	therapy	therapy	NOUN
cusj-5588	203	33	techniques	technique	NOUN
cusj-5588	203	34	carry	carry	VERB
cusj-5588	203	35	significant	significant	ADJ
cusj-5588	203	36	therapeutic	therapeutic	ADJ
cusj-5588	203	37	potential	potential	NOUN
cusj-5588	203	38	.	.	PUNCT
cusj-5588	204	1	carroll	carroll	NOUN
cusj-5588	204	2	et	et	PROPN
cusj-5588	204	3	al	al	PROPN
cusj-5588	204	4	.	.	PROPN
cusj-5588	205	1	(	(	PUNCT
cusj-5588	205	2	2011	2011	NUM
cusj-5588	205	3	)	)	PUNCT
cusj-5588	205	4	have	have	AUX
cusj-5588	205	5	developed	develop	VERB
cusj-5588	205	6	asos	asos	NOUN
cusj-5588	205	7	that	that	PRON
cusj-5588	205	8	selectively	selectively	ADV
cusj-5588	205	9	bind	bind	VERB
cusj-5588	205	10	to	to	ADP
cusj-5588	205	11	exonic	exonic	NOUN
cusj-5588	205	12	and	and	CCONJ
cusj-5588	205	13	intronic	intronic	ADJ
cusj-5588	205	14	snp	snp	NOUN
cusj-5588	205	15	(	(	PUNCT
cusj-5588	205	16	single	single	ADJ
cusj-5588	205	17	nucleotide	nucleotide	ADJ
cusj-5588	205	18	polymorphisms	polymorphism	NOUN
cusj-5588	205	19	)	)	PUNCT
cusj-5588	205	20	sites	site	NOUN
cusj-5588	205	21	on	on	ADP
cusj-5588	205	22	the	the	DET
cusj-5588	205	23	mutant	mutant	ADJ
cusj-5588	205	24	huntingtin	huntingtin	NOUN
cusj-5588	205	25	protein	protein	NOUN
cusj-5588	205	26	(	(	PUNCT
cusj-5588	205	27	mhtt	mhtt	PROPN
cusj-5588	205	28	)	)	PUNCT
cusj-5588	205	29	,	,	PUNCT
cusj-5588	205	30	thus	thus	ADV
cusj-5588	205	31	selectively	selectively	ADV
cusj-5588	205	32	silencing	silence	VERB
cusj-5588	205	33	gene	gene	NOUN
cusj-5588	205	34	expression	expression	NOUN
cusj-5588	205	35	of	of	ADP
cusj-5588	205	36	mutated	mutate	VERB
cusj-5588	205	37	regions	region	NOUN
cusj-5588	205	38	on	on	ADP
cusj-5588	205	39	the	the	DET
cusj-5588	205	40	mhtt	mhtt	NOUN
cusj-5588	205	41	.	.	PUNCT
cusj-5588	206	1	the	the	DET
cusj-5588	206	2	experiment	experiment	NOUN
cusj-5588	206	3	used	use	VERB
cusj-5588	206	4	primary	primary	ADJ
cusj-5588	206	5	cells	cell	NOUN
cusj-5588	206	6	from	from	ADP
cusj-5588	206	7	hdpatients	hdpatient	NOUN
cusj-5588	206	8	with	with	ADP
cusj-5588	206	9	transgenic	transgenic	NOUN
cusj-5588	206	10	mouse	mouse	NOUN
cusj-5588	206	11	lines	line	NOUN
cusj-5588	206	12	,	,	PUNCT
cusj-5588	206	13	and	and	CCONJ
cusj-5588	206	14	the	the	DET
cusj-5588	206	15	developed	develop	VERB
cusj-5588	206	16	asos	asos	NOUN
cusj-5588	206	17	achieved	achieve	VERB
cusj-5588	206	18	potent	potent	ADJ
cusj-5588	206	19	and	and	CCONJ
cusj-5588	206	20	selective	selective	ADJ
cusj-5588	206	21	allele	allele	NOUN
cusj-5588	206	22	-	-	PUNCT
cusj-5588	206	23	specific	specific	ADJ
cusj-5588	206	24	knockdown	knockdown	NOUN
cusj-5588	206	25	of	of	ADP
cusj-5588	206	26	mhtt	mhtt	NOUN
cusj-5588	206	27	both	both	CCONJ
cusj-5588	206	28	in	in	ADP
cusj-5588	206	29	vitro	vitro	X
cusj-5588	206	30	and	and	CCONJ
cusj-5588	206	31	in	in	ADP
cusj-5588	206	32	vivo	vivo	NOUN
cusj-5588	206	33	.	.	PUNCT
cusj-5588	207	1	this	this	PRON
cusj-5588	207	2	presents	present	VERB
cusj-5588	207	3	the	the	DET
cusj-5588	207	4	most	most	ADV
cusj-5588	207	5	exciting	exciting	ADJ
cusj-5588	207	6	potential	potential	ADJ
cusj-5588	207	7	treatment	treatment	NOUN
cusj-5588	207	8	for	for	ADP
cusj-5588	207	9	huntington	huntington	PROPN
cusj-5588	207	10	’s	’s	PART
cusj-5588	207	11	,	,	PUNCT
cusj-5588	207	12	as	as	SCONJ
cusj-5588	207	13	aso	aso	NOUN
cusj-5588	207	14	delivery	delivery	NOUN
cusj-5588	207	15	to	to	PART
cusj-5588	207	16	adult	adult	VERB
cusj-5588	207	17	cns	cns	NOUN
cusj-5588	207	18	can	can	AUX
cusj-5588	207	19	be	be	AUX
cusj-5588	207	20	achieved	achieve	VERB
cusj-5588	207	21	through	through	ADP
cusj-5588	207	22	simple	simple	ADJ
cusj-5588	207	23	intrathecal	intrathecal	ADJ
cusj-5588	207	24	or	or	CCONJ
cusj-5588	207	25	intracerebroventricular	intracerebroventricular	ADJ
cusj-5588	207	26	infusion	infusion	NOUN
cusj-5588	207	27	rather	rather	ADV
cusj-5588	207	28	than	than	ADP
cusj-5588	207	29	viral	viral	ADJ
cusj-5588	207	30	delivery	delivery	NOUN
cusj-5588	207	31	.	.	PUNCT
cusj-5588	208	1	further	far	ADV
cusj-5588	208	2	,	,	PUNCT
cusj-5588	208	3	aso	aso	PROPN
cusj-5588	208	4	dosing	dosing	PROPN
cusj-5588	208	5	can	can	AUX
cusj-5588	208	6	be	be	AUX
cusj-5588	208	7	precisely	precisely	ADV
cusj-5588	208	8	controlled	control	VERB
cusj-5588	208	9	or	or	CCONJ
cusj-5588	208	10	stopped	stop	VERB
cusj-5588	208	11	when	when	SCONJ
cusj-5588	208	12	necessary	necessary	ADJ
cusj-5588	208	13	.	.	PUNCT
cusj-5588	209	1	kordasiewicz	kordasiewicz	VERB
cusj-5588	209	2	et	et	PROPN
cusj-5588	209	3	al	al	PROPN
cusj-5588	209	4	.	.	PROPN
cusj-5588	210	1	(	(	PUNCT
cusj-5588	210	2	2012	2012	NUM
cusj-5588	210	3	)	)	PUNCT
cusj-5588	210	4	have	have	AUX
cusj-5588	210	5	shown	show	VERB
cusj-5588	210	6	that	that	SCONJ
cusj-5588	210	7	transient	transient	ADJ
cusj-5588	210	8	infusion	infusion	NOUN
cusj-5588	210	9	of	of	ADP
cusj-5588	210	10	asos	asos	NOUN
cusj-5588	210	11	catalysing	catalyse	VERB
cusj-5588	210	12	rnase	rnase	PROPN
cusj-5588	210	13	h	h	NOUN
cusj-5588	210	14	-	-	PUNCT
cusj-5588	210	15	mediated	mediate	VERB
cusj-5588	210	16	degredation	degredation	NOUN
cusj-5588	210	17	of	of	ADP
cusj-5588	210	18	mhtt	mhtt	PROPN
cusj-5588	210	19	in	in	ADP
cusj-5588	210	20	mouse	mouse	PROPN
cusj-5588	210	21	and	and	CCONJ
cusj-5588	210	22	non	non	ADJ
cusj-5588	210	23	-	-	ADJ
cusj-5588	210	24	human	human	ADJ
cusj-5588	210	25	primate	primate	NOUN
cusj-5588	210	26	models	model	NOUN
cusj-5588	210	27	delays	delay	NOUN
cusj-5588	210	28	disease	disease	NOUN
cusj-5588	210	29	progression	progression	NOUN
cusj-5588	210	30	and	and	CCONJ
cusj-5588	210	31	sustains	sustain	VERB
cusj-5588	210	32	hd	hd	NOUN
cusj-5588	210	33	disease	disease	NOUN
cusj-5588	210	34	reversal	reversal	NOUN
cusj-5588	210	35	that	that	PRON
cusj-5588	210	36	outlasts	outlast	VERB
cusj-5588	210	37	aso	aso	NOUN
cusj-5588	210	38	-	-	PUNCT
cusj-5588	210	39	mediated	mediate	VERB
cusj-5588	210	40	mhtt	mhtt	PROPN
cusj-5588	210	41	knockdown	knockdown	NOUN
cusj-5588	210	42	.	.	PUNCT
cusj-5588	211	1	thus	thus	ADV
cusj-5588	211	2	,	,	PUNCT
cusj-5588	211	3	clinical	clinical	ADJ
cusj-5588	211	4	trials	trial	NOUN
cusj-5588	211	5	should	should	AUX
cusj-5588	211	6	be	be	AUX
cusj-5588	211	7	conducted	conduct	VERB
cusj-5588	211	8	to	to	PART
cusj-5588	211	9	test	test	VERB
cusj-5588	211	10	the	the	DET
cusj-5588	211	11	efficacy	efficacy	NOUN
cusj-5588	211	12	of	of	ADP
cusj-5588	211	13	gene	gene	NOUN
cusj-5588	211	14	therapy	therapy	NOUN
cusj-5588	211	15	either	either	CCONJ
cusj-5588	211	16	through	through	ADP
cusj-5588	211	17	direct	direct	ADJ
cusj-5588	211	18	aso	aso	NOUN
cusj-5588	211	19	infusion	infusion	NOUN
cusj-5588	211	20	,	,	PUNCT
cusj-5588	211	21	or	or	CCONJ
cusj-5588	211	22	combined	combine	VERB
cusj-5588	211	23	with	with	ADP
cusj-5588	211	24	ipsc	ipsc	NOUN
cusj-5588	211	25	-	-	PUNCT
cusj-5588	211	26	mediated	mediate	VERB
cusj-5588	211	27	transplantation	transplantation	NOUN
cusj-5588	211	28	(	(	PUNCT
cusj-5588	211	29	correcting	correct	VERB
cusj-5588	211	30	disease	disease	NOUN
cusj-5588	211	31	mutations	mutation	NOUN
cusj-5588	211	32	of	of	ADP
cusj-5588	211	33	patient	patient	NOUN
cusj-5588	211	34	-	-	PUNCT
cusj-5588	211	35	derived	derive	VERB
cusj-5588	211	36	ipscs	ipscs	NOUN
cusj-5588	211	37	with	with	ADP
cusj-5588	211	38	asos	asos	PROPN
cusj-5588	211	39	,	,	PUNCT
cusj-5588	211	40	then	then	ADV
cusj-5588	211	41	transplanting	transplant	VERB
cusj-5588	211	42	corrected	correct	VERB
cusj-5588	211	43	npcs	npc	NOUN
cusj-5588	211	44	)	)	PUNCT
cusj-5588	211	45	.	.	PUNCT
cusj-5588	212	1	low	low	ADJ
cusj-5588	212	2	efficacy	efficacy	NOUN
cusj-5588	212	3	in	in	ADP
cusj-5588	212	4	gene	gene	NOUN
cusj-5588	212	5	therapies	therapy	NOUN
cusj-5588	212	6	promising	promise	VERB
cusj-5588	212	7	proof	proof	NOUN
cusj-5588	212	8	-	-	PUNCT
cusj-5588	212	9	of	of	ADP
cusj-5588	212	10	-	-	PUNCT
cusj-5588	212	11	principle	principle	NOUN
cusj-5588	212	12	concepts	concept	NOUN
cusj-5588	212	13	have	have	AUX
cusj-5588	212	14	been	be	AUX
cusj-5588	212	15	presented	present	VERB
cusj-5588	212	16	in	in	ADP
cusj-5588	212	17	phase	phase	NOUN
cusj-5588	212	18	i	i	PRON
cusj-5588	212	19	trials	trial	NOUN
cusj-5588	212	20	,	,	PUNCT
cusj-5588	212	21	which	which	PRON
cusj-5588	212	22	have	have	AUX
cusj-5588	212	23	shown	show	VERB
cusj-5588	212	24	that	that	SCONJ
cusj-5588	212	25	gene	gene	NOUN
cusj-5588	212	26	therapy	therapy	NOUN
cusj-5588	212	27	techniques	technique	NOUN
cusj-5588	212	28	targeting	target	VERB
cusj-5588	212	29	ad	ad	NOUN
cusj-5588	212	30	&	&	CCONJ
cusj-5588	212	31	pd	pd	PROPN
cusj-5588	212	32	are	be	AUX
cusj-5588	212	33	safe	safe	ADJ
cusj-5588	212	34	and	and	CCONJ
cusj-5588	212	35	welltolerated	welltolerate	VERB
cusj-5588	212	36	.	.	PUNCT
cusj-5588	213	1	however	however	ADV
cusj-5588	213	2	,	,	PUNCT
cusj-5588	213	3	therapeutic	therapeutic	ADJ
cusj-5588	213	4	efficacy	efficacy	NOUN
cusj-5588	213	5	in	in	ADP
cusj-5588	213	6	further	further	ADJ
cusj-5588	213	7	clinical	clinical	ADJ
cusj-5588	213	8	trials	trial	NOUN
cusj-5588	213	9	remains	remain	VERB
cusj-5588	213	10	weak	weak	ADJ
cusj-5588	213	11	,	,	PUNCT
cusj-5588	213	12	in	in	SCONJ
cusj-5588	213	13	that	that	DET
cusj-5588	213	14	observed	observe	VERB
cusj-5588	213	15	improvements	improvement	NOUN
cusj-5588	213	16	failed	fail	VERB
cusj-5588	213	17	to	to	PART
cusj-5588	213	18	exceed	exceed	VERB
cusj-5588	213	19	placebo	placebo	NOUN
cusj-5588	213	20	effect	effect	NOUN
cusj-5588	213	21	or	or	CCONJ
cusj-5588	213	22	current	current	ADJ
cusj-5588	213	23	standards	standard	NOUN
cusj-5588	213	24	of	of	ADP
cusj-5588	213	25	care	care	NOUN
cusj-5588	213	26	for	for	ADP
cusj-5588	213	27	ad	ad	NOUN
cusj-5588	213	28	and	and	CCONJ
cusj-5588	213	29	11	11	NUM
cusj-5588	213	30	cusj	cusj	NOUN
cusj-5588	213	31	2018	2018	NUM
cusj-5588	213	32	_	_	PUNCT
cusj-5588	214	1	_	_	PUNCT
cusj-5588	215	1	_	_	PUNCT
cusj-5588	216	1	_	_	PUNCT
cusj-5588	217	1	_	_	PUNCT
cusj-5588	218	1	_	_	PUNCT
cusj-5588	219	1	_	_	PUNCT
cusj-5588	220	1	_	_	PUNCT
cusj-5588	221	1	_	_	PUNCT
cusj-5588	222	1	_	_	PUNCT
cusj-5588	223	1	_	_	PUNCT
cusj-5588	224	1	_	_	PUNCT
cusj-5588	225	1	_	_	PUNCT
cusj-5588	226	1	_	_	PUNCT
cusj-5588	227	1	_	_	PUNCT
cusj-5588	228	1	_	_	PUNCT
cusj-5588	229	1	_	_	PUNCT
cusj-5588	230	1	_	_	PUNCT
cusj-5588	231	1	_	_	PUNCT
cusj-5588	232	1	_	_	PUNCT
cusj-5588	233	1	_	_	PUNCT
cusj-5588	234	1	_	_	PUNCT
cusj-5588	235	1	_	_	PUNCT
cusj-5588	236	1	_	_	PUNCT
cusj-5588	237	1	_	_	PUNCT
cusj-5588	238	1	_	_	PUNCT
cusj-5588	239	1	_	_	PUNCT
cusj-5588	240	1	_	_	PUNCT
cusj-5588	241	1	_	_	PUNCT
cusj-5588	242	1	_	_	PUNCT
cusj-5588	243	1	_	_	PUNCT
cusj-5588	244	1	_	_	PUNCT
cusj-5588	245	1	_	_	PUNCT
cusj-5588	246	1	_	_	PUNCT
cusj-5588	247	1	_	_	PUNCT
cusj-5588	248	1	_	_	PUNCT
cusj-5588	249	1	_	_	PUNCT
cusj-5588	250	1	_	_	PUNCT
cusj-5588	251	1	_	_	PUNCT
cusj-5588	252	1	_	_	PUNCT
cusj-5588	253	1	_	_	PUNCT
cusj-5588	254	1	_	_	PUNCT
cusj-5588	255	1	_	_	PUNCT
cusj-5588	256	1	_	_	PUNCT
cusj-5588	257	1	_	_	PUNCT
cusj-5588	258	1	_	_	PUNCT
cusj-5588	259	1	_	_	PUNCT
cusj-5588	260	1	_	_	PUNCT
cusj-5588	261	1	_	_	PUNCT
cusj-5588	262	1	_	_	PUNCT
cusj-5588	263	1	_	_	PUNCT
cusj-5588	264	1	_	_	PUNCT
cusj-5588	265	1	_	_	PUNCT
cusj-5588	266	1	_	_	PUNCT
cusj-5588	267	1	_	_	PUNCT
cusj-5588	268	1	_	_	PUNCT
cusj-5588	269	1	_	_	PUNCT
cusj-5588	270	1	_	_	PUNCT
cusj-5588	271	1	_	_	PUNCT
cusj-5588	272	1	_	_	PUNCT
cusj-5588	273	1	_	_	PUNCT
cusj-5588	274	1	_	_	PUNCT
cusj-5588	275	1	_	_	PUNCT
cusj-5588	276	1	_	_	PUNCT
cusj-5588	277	1	_	_	PUNCT
cusj-5588	278	1	_	_	PUNCT
cusj-5588	279	1	_	_	PUNCT
cusj-5588	280	1	_	_	PUNCT
cusj-5588	281	1	_	_	PUNCT
cusj-5588	282	1	_	_	PUNCT
cusj-5588	283	1	_	_	PUNCT
cusj-5588	284	1	_	_	PUNCT
cusj-5588	285	1	_	_	PUNCT
cusj-5588	286	1	_	_	PUNCT
cusj-5588	287	1	_	_	PUNCT
cusj-5588	288	1	_	_	PUNCT
cusj-5588	289	1	_	_	PUNCT
cusj-5588	290	1	_	_	PUNCT
cusj-5588	291	1	_	_	PUNCT
cusj-5588	291	2	_	_	PUNCT
cusj-5588	292	1	pd	pd	X
cusj-5588	292	2	.	.	PUNCT
cusj-5588	292	3	non	non	ADJ
cusj-5588	292	4	-	-	ADJ
cusj-5588	292	5	viral	viral	ADJ
cusj-5588	292	6	aso	aso	NOUN
cusj-5588	292	7	-	-	PUNCT
cusj-5588	292	8	mediated	mediate	VERB
cusj-5588	292	9	silencing	silencing	NOUN
cusj-5588	292	10	of	of	ADP
cusj-5588	292	11	mhtt	mhtt	NOUN
cusj-5588	292	12	expression	expression	NOUN
cusj-5588	292	13	has	have	AUX
cusj-5588	292	14	proved	prove	VERB
cusj-5588	292	15	efficacious	efficacious	ADJ
cusj-5588	292	16	in	in	ADP
cusj-5588	292	17	hd	hd	NOUN
cusj-5588	292	18	-	-	NOUN
cusj-5588	292	19	animal	animal	NOUN
cusj-5588	292	20	models	model	NOUN
cusj-5588	292	21	but	but	CCONJ
cusj-5588	292	22	have	have	AUX
cusj-5588	292	23	not	not	PART
cusj-5588	292	24	yet	yet	ADV
cusj-5588	292	25	moved	move	VERB
cusj-5588	292	26	to	to	ADP
cusj-5588	292	27	clinical	clinical	ADJ
cusj-5588	292	28	trials	trial	NOUN
cusj-5588	292	29	.	.	PUNCT
cusj-5588	293	1	in	in	ADP
cusj-5588	293	2	sum	sum	NOUN
cusj-5588	293	3	,	,	PUNCT
cusj-5588	293	4	success	success	NOUN
cusj-5588	293	5	by	by	ADP
cusj-5588	293	6	design	design	NOUN
cusj-5588	293	7	meets	meet	VERB
cusj-5588	293	8	failure	failure	NOUN
cusj-5588	293	9	of	of	ADP
cusj-5588	293	10	efficacy	efficacy	NOUN
cusj-5588	293	11	within	within	ADP
cusj-5588	293	12	these	these	DET
cusj-5588	293	13	gene	gene	NOUN
cusj-5588	293	14	therapy	therapy	NOUN
cusj-5588	293	15	studies	study	NOUN
cusj-5588	293	16	.	.	PUNCT
cusj-5588	294	1	moving	move	VERB
cusj-5588	294	2	forward	forward	ADV
cusj-5588	294	3	,	,	PUNCT
cusj-5588	294	4	future	future	ADJ
cusj-5588	294	5	research	research	NOUN
cusj-5588	294	6	must	must	AUX
cusj-5588	294	7	focus	focus	VERB
cusj-5588	294	8	first	first	ADV
cusj-5588	294	9	on	on	ADP
cusj-5588	294	10	expanding	expand	VERB
cusj-5588	294	11	choices	choice	NOUN
cusj-5588	294	12	of	of	ADP
cusj-5588	294	13	possible	possible	ADJ
cusj-5588	294	14	transgenes	transgene	NOUN
cusj-5588	294	15	for	for	ADP
cusj-5588	294	16	delivery	delivery	NOUN
cusj-5588	294	17	,	,	PUNCT
cusj-5588	294	18	as	as	SCONJ
cusj-5588	294	19	improvements	improvement	NOUN
cusj-5588	294	20	in	in	ADP
cusj-5588	294	21	vectors	vector	NOUN
cusj-5588	294	22	and	and	CCONJ
cusj-5588	294	23	delivery	delivery	NOUN
cusj-5588	294	24	methods	method	NOUN
cusj-5588	294	25	depend	depend	VERB
cusj-5588	294	26	crucially	crucially	ADV
cusj-5588	294	27	on	on	ADP
cusj-5588	294	28	efficacy	efficacy	NOUN
cusj-5588	294	29	of	of	ADP
cusj-5588	294	30	the	the	DET
cusj-5588	294	31	transgene	transgene	NOUN
cusj-5588	294	32	delivered	deliver	VERB
cusj-5588	294	33	.	.	PUNCT
cusj-5588	295	1	greater	great	ADJ
cusj-5588	295	2	understanding	understanding	NOUN
cusj-5588	295	3	in	in	ADP
cusj-5588	295	4	disease	disease	NOUN
cusj-5588	295	5	etiology	etiology	NOUN
cusj-5588	295	6	will	will	AUX
cusj-5588	295	7	help	help	AUX
cusj-5588	295	8	identify	identify	VERB
cusj-5588	295	9	these	these	DET
cusj-5588	295	10	gene	gene	NOUN
cusj-5588	295	11	targets	target	NOUN
cusj-5588	295	12	.	.	PUNCT
cusj-5588	296	1	a	a	DET
cusj-5588	296	2	significant	significant	ADJ
cusj-5588	296	3	area	area	NOUN
cusj-5588	296	4	of	of	ADP
cusj-5588	296	5	development	development	NOUN
cusj-5588	296	6	lies	lie	VERB
cusj-5588	296	7	in	in	ADP
cusj-5588	296	8	the	the	DET
cusj-5588	296	9	identification	identification	NOUN
cusj-5588	296	10	of	of	ADP
cusj-5588	296	11	biomarkers	biomarker	NOUN
cusj-5588	296	12	of	of	ADP
cusj-5588	296	13	nds	nds	PROPN
cusj-5588	296	14	,	,	PUNCT
cusj-5588	296	15	which	which	PRON
cusj-5588	296	16	would	would	AUX
cusj-5588	296	17	not	not	PART
cusj-5588	296	18	only	only	ADV
cusj-5588	296	19	improve	improve	VERB
cusj-5588	296	20	gene	gene	NOUN
cusj-5588	296	21	therapy	therapy	NOUN
cusj-5588	296	22	techniques	technique	NOUN
cusj-5588	296	23	,	,	PUNCT
cusj-5588	296	24	but	but	CCONJ
cusj-5588	296	25	also	also	ADV
cusj-5588	296	26	allow	allow	VERB
cusj-5588	296	27	for	for	ADP
cusj-5588	296	28	earlier	early	ADJ
cusj-5588	296	29	diagnoses	diagnosis	NOUN
cusj-5588	296	30	,	,	PUNCT
cusj-5588	296	31	continuous	continuous	ADJ
cusj-5588	296	32	motoring	motoring	NOUN
cusj-5588	296	33	of	of	ADP
cusj-5588	296	34	the	the	DET
cusj-5588	296	35	progression	progression	NOUN
cusj-5588	296	36	of	of	ADP
cusj-5588	296	37	therapeutic	therapeutic	ADJ
cusj-5588	296	38	effects	effect	NOUN
cusj-5588	296	39	,	,	PUNCT
cusj-5588	296	40	and	and	CCONJ
cusj-5588	296	41	the	the	DET
cusj-5588	296	42	development	development	NOUN
cusj-5588	296	43	of	of	ADP
cusj-5588	296	44	precision	precision	NOUN
cusj-5588	296	45	medicine	medicine	NOUN
cusj-5588	296	46	.	.	PUNCT
cusj-5588	297	1	part	part	NOUN
cusj-5588	297	2	3	3	NUM
cusj-5588	297	3	:	:	PUNCT
cusj-5588	297	4	stem	stem	NOUN
cusj-5588	297	5	cell	cell	NOUN
cusj-5588	297	6	therapy3	therapy3	NOUN
cusj-5588	297	7	stem	stem	NOUN
cusj-5588	297	8	cell	cell	NOUN
cusj-5588	297	9	and	and	CCONJ
cusj-5588	297	10	ipsc	ipsc	PROPN
cusj-5588	297	11	research	research	PROPN
cusj-5588	297	12	has	have	AUX
cusj-5588	297	13	significantly	significantly	ADV
cusj-5588	297	14	furthered	further	VERB
cusj-5588	297	15	neurodegenerative	neurodegenerative	ADJ
cusj-5588	297	16	disease	disease	NOUN
cusj-5588	297	17	modelling	modelling	NOUN
cusj-5588	297	18	,	,	PUNCT
cusj-5588	297	19	diagnosis	diagnosis	NOUN
cusj-5588	297	20	,	,	PUNCT
cusj-5588	297	21	and	and	CCONJ
cusj-5588	297	22	transplantand	transplantand	NOUN
cusj-5588	297	23	drug	drug	NOUN
cusj-5588	297	24	-	-	PUNCT
cusj-5588	297	25	based	base	VERB
cusj-5588	297	26	therapies	therapy	NOUN
cusj-5588	297	27	.	.	PUNCT
cusj-5588	298	1	a	a	DET
cusj-5588	298	2	plethora	plethora	NOUN
cusj-5588	298	3	of	of	ADP
cusj-5588	298	4	therapies	therapy	NOUN
cusj-5588	298	5	developed	develop	VERB
cusj-5588	298	6	in	in	ADP
cusj-5588	298	7	animal	animal	NOUN
cusj-5588	298	8	models	model	NOUN
cusj-5588	298	9	have	have	AUX
cusj-5588	298	10	failed	fail	VERB
cusj-5588	298	11	to	to	PART
cusj-5588	298	12	translate	translate	VERB
cusj-5588	298	13	into	into	ADP
cusj-5588	298	14	effective	effective	ADJ
cusj-5588	298	15	clinical	clinical	ADJ
cusj-5588	298	16	trials	trial	NOUN
cusj-5588	298	17	due	due	ADP
cusj-5588	298	18	to	to	ADP
cusj-5588	298	19	differences	difference	NOUN
cusj-5588	298	20	in	in	ADP
cusj-5588	298	21	mammalian	mammalian	ADJ
cusj-5588	298	22	genomes	genome	NOUN
cusj-5588	298	23	and	and	CCONJ
cusj-5588	298	24	embryonic	embryonic	ADJ
cusj-5588	298	25	development	development	NOUN
cusj-5588	298	26	(	(	PUNCT
cusj-5588	298	27	begley	begley	PROPN
cusj-5588	298	28	&	&	CCONJ
cusj-5588	298	29	ellis	ellis	PROPN
cusj-5588	298	30	,	,	PUNCT
cusj-5588	298	31	2012	2012	NUM
cusj-5588	298	32	)	)	PUNCT
cusj-5588	298	33	.	.	PUNCT
cusj-5588	299	1	human	human	NOUN
cusj-5588	299	2	-	-	PUNCT
cusj-5588	299	3	based	base	VERB
cusj-5588	299	4	stem	stem	NOUN
cusj-5588	299	5	cell	cell	NOUN
cusj-5588	299	6	research	research	NOUN
cusj-5588	299	7	generates	generate	VERB
cusj-5588	299	8	not	not	PART
cusj-5588	299	9	only	only	ADV
cusj-5588	299	10	potential	potential	ADJ
cusj-5588	299	11	nd	nd	PRON
cusj-5588	299	12	therapies	therapy	NOUN
cusj-5588	299	13	,	,	PUNCT
cusj-5588	299	14	but	but	CCONJ
cusj-5588	299	15	also	also	ADV
cusj-5588	299	16	presents	present	VERB
cusj-5588	299	17	clearer	clear	ADJ
cusj-5588	299	18	pathophysiological	pathophysiological	ADJ
cusj-5588	299	19	models	model	NOUN
cusj-5588	299	20	for	for	ADP
cusj-5588	299	21	those	those	DET
cusj-5588	299	22	diseases	disease	NOUN
cusj-5588	299	23	.	.	PUNCT
cusj-5588	300	1	in	in	ADP
cusj-5588	300	2	particular	particular	ADJ
cusj-5588	300	3	,	,	PUNCT
cusj-5588	300	4	the	the	DET
cusj-5588	300	5	development	development	NOUN
cusj-5588	300	6	of	of	ADP
cusj-5588	300	7	induced	induced	ADJ
cusj-5588	300	8	pluripotent	pluripotent	ADJ
cusj-5588	300	9	stem	stem	NOUN
cusj-5588	300	10	(	(	PUNCT
cusj-5588	300	11	ips	ip	NOUN
cusj-5588	300	12	)	)	PUNCT
cusj-5588	300	13	cells	cell	NOUN
cusj-5588	300	14	has	have	AUX
cusj-5588	300	15	presented	present	VERB
cusj-5588	300	16	a	a	DET
cusj-5588	300	17	unique	unique	ADJ
cusj-5588	300	18	approach	approach	NOUN
cusj-5588	300	19	for	for	ADP
cusj-5588	300	20	studying	study	VERB
cusj-5588	300	21	signalling	signal	VERB
cusj-5588	300	22	pathways	pathway	NOUN
cusj-5588	300	23	,	,	PUNCT
cusj-5588	300	24	growth	growth	NOUN
cusj-5588	300	25	control	control	NOUN
cusj-5588	300	26	,	,	PUNCT
cusj-5588	300	27	and	and	CCONJ
cusj-5588	300	28	disease	disease	NOUN
cusj-5588	300	29	mechanisms	mechanism	NOUN
cusj-5588	300	30	in	in	ADP
cusj-5588	300	31	previously	previously	ADV
cusj-5588	300	32	inaccessible	inaccessible	ADJ
cusj-5588	300	33	human	human	ADJ
cusj-5588	300	34	brain	brain	NOUN
cusj-5588	300	35	tissue	tissue	NOUN
cusj-5588	300	36	.	.	PUNCT
cusj-5588	301	1	the	the	DET
cusj-5588	301	2	main	main	ADJ
cusj-5588	301	3	types	type	NOUN
cusj-5588	301	4	of	of	ADP
cusj-5588	301	5	stem	stem	NOUN
cusj-5588	301	6	cells	cell	NOUN
cusj-5588	301	7	used	use	VERB
cusj-5588	301	8	for	for	ADP
cusj-5588	301	9	neurodegenerative	neurodegenerative	ADJ
cusj-5588	301	10	therapies	therapy	NOUN
cusj-5588	301	11	are	be	AUX
cusj-5588	301	12	embryonic	embryonic	ADJ
cusj-5588	301	13	,	,	PUNCT
cusj-5588	301	14	mesenchymal	mesenchymal	NOUN
cusj-5588	301	15	,	,	PUNCT
cusj-5588	301	16	progenitor	progenitor	NOUN
cusj-5588	301	17	,	,	PUNCT
cusj-5588	301	18	and	and	CCONJ
cusj-5588	301	19	ips	ip	NOUN
cusj-5588	301	20	cells	cell	NOUN
cusj-5588	301	21	(	(	PUNCT
cusj-5588	301	22	singh	singh	PROPN
cusj-5588	301	23	et	et	PROPN
cusj-5588	301	24	al	al	PROPN
cusj-5588	301	25	.	.	PROPN
cusj-5588	301	26	,	,	PUNCT
cusj-5588	301	27	2016	2016	NUM
cusj-5588	301	28	)	)	PUNCT
cusj-5588	301	29	.	.	PUNCT
cusj-5588	302	1	embryonic	embryonic	ADJ
cusj-5588	302	2	stem	stem	NOUN
cusj-5588	302	3	cells	cell	NOUN
cusj-5588	302	4	are	be	AUX
cusj-5588	302	5	pluripotent	pluripotent	ADJ
cusj-5588	302	6	and	and	CCONJ
cusj-5588	302	7	hold	hold	VERB
cusj-5588	302	8	excellent	excellent	ADJ
cusj-5588	302	9	potential	potential	NOUN
cusj-5588	302	10	to	to	PART
cusj-5588	302	11	restore	restore	VERB
cusj-5588	302	12	damage	damage	NOUN
cusj-5588	302	13	caused	cause	VERB
cusj-5588	302	14	by	by	ADP
cusj-5588	302	15	brain	brain	NOUN
cusj-5588	302	16	injury	injury	NOUN
cusj-5588	302	17	or	or	CCONJ
cusj-5588	302	18	neurodegeneration	neurodegeneration	NOUN
cusj-5588	302	19	;	;	PUNCT
cusj-5588	302	20	however	however	ADV
cusj-5588	302	21	,	,	PUNCT
cusj-5588	302	22	their	their	PRON
cusj-5588	302	23	ability	ability	NOUN
cusj-5588	302	24	for	for	ADP
cusj-5588	302	25	unlimited	unlimited	ADJ
cusj-5588	302	26	self	self	NOUN
cusj-5588	302	27	-	-	PUNCT
cusj-5588	302	28	renewal	renewal	NOUN
cusj-5588	302	29	poses	pose	NOUN
cusj-5588	302	30	a	a	DET
cusj-5588	302	31	high	high	ADJ
cusj-5588	302	32	risk	risk	NOUN
cusj-5588	302	33	for	for	ADP
cusj-5588	302	34	tumour	tumour	NOUN
cusj-5588	302	35	formation	formation	NOUN
cusj-5588	302	36	postengraftment	postengraftment	NOUN
cusj-5588	302	37	,	,	PUNCT
cusj-5588	302	38	limiting	limit	VERB
cusj-5588	302	39	the	the	DET
cusj-5588	302	40	range	range	NOUN
cusj-5588	302	41	of	of	ADP
cusj-5588	302	42	their	their	PRON
cusj-5588	302	43	clinical	clinical	ADJ
cusj-5588	302	44	application	application	NOUN
cusj-5588	302	45	.	.	PUNCT
cusj-5588	303	1	mesenchymal	mesenchymal	ADJ
cusj-5588	303	2	stem	stem	NOUN
cusj-5588	303	3	cells	cell	NOUN
cusj-5588	303	4	are	be	AUX
cusj-5588	303	5	multipotent	multipotent	ADJ
cusj-5588	303	6	and	and	CCONJ
cusj-5588	303	7	immunomodulating	immunomodulate	VERB
cusj-5588	303	8	(	(	PUNCT
cusj-5588	303	9	derived	derive	VERB
cusj-5588	303	10	from	from	ADP
cusj-5588	303	11	autologous	autologous	ADJ
cusj-5588	303	12	source	source	NOUN
cusj-5588	303	13	;	;	PUNCT
cusj-5588	303	14	do	do	AUX
cusj-5588	303	15	not	not	PART
cusj-5588	303	16	trigger	trigger	VERB
cusj-5588	303	17	a	a	DET
cusj-5588	303	18	host	host	NOUN
cusj-5588	303	19	immune	immune	ADJ
cusj-5588	303	20	response	response	NOUN
cusj-5588	303	21	)	)	PUNCT
cusj-5588	303	22	,	,	PUNCT
cusj-5588	303	23	and	and	CCONJ
cusj-5588	303	24	thus	thus	ADV
cusj-5588	303	25	find	find	VERB
cusj-5588	303	26	a	a	DET
cusj-5588	303	27	relatively	relatively	ADV
cusj-5588	303	28	widespread	widespread	ADJ
cusj-5588	303	29	application	application	NOUN
cusj-5588	303	30	for	for	ADP
cusj-5588	303	31	neurodegenerative	neurodegenerative	ADJ
cusj-5588	303	32	treatment	treatment	NOUN
cusj-5588	303	33	.	.	PUNCT
cusj-5588	304	1	however	however	ADV
cusj-5588	304	2	,	,	PUNCT
cusj-5588	304	3	their	their	PRON
cusj-5588	304	4	use	use	NOUN
cusj-5588	304	5	in	in	ADP
cusj-5588	304	6	genetic	genetic	ADJ
cusj-5588	304	7	diseases	disease	NOUN
cusj-5588	304	8	,	,	PUNCT
cusj-5588	304	9	wherein	wherein	SCONJ
cusj-5588	304	10	autologous	autologous	ADJ
cusj-5588	304	11	sources	source	NOUN
cusj-5588	304	12	contain	contain	VERB
cusj-5588	304	13	the	the	DET
cusj-5588	304	14	same	same	ADJ
cusj-5588	304	15	genetic	genetic	ADJ
cusj-5588	304	16	predisposition	predisposition	NOUN
cusj-5588	304	17	to	to	ADP
cusj-5588	304	18	the	the	DET
cusj-5588	304	19	disease	disease	NOUN
cusj-5588	304	20	,	,	PUNCT
cusj-5588	304	21	is	be	AUX
cusj-5588	304	22	limited	limited	ADJ
cusj-5588	304	23	.	.	PUNCT
cusj-5588	305	1	neural	neural	ADJ
cusj-5588	305	2	progenitor	progenitor	NOUN
cusj-5588	305	3	cells	cell	NOUN
cusj-5588	305	4	(	(	PUNCT
cusj-5588	305	5	npc	npc	NOUN
cusj-5588	305	6	)	)	PUNCT
cusj-5588	305	7	and	and	CCONJ
cusj-5588	305	8	neural	neural	ADJ
cusj-5588	305	9	stem	stem	NOUN
cusj-5588	305	10	cells	cell	NOUN
cusj-5588	305	11	(	(	PUNCT
cusj-5588	305	12	nsc	nsc	PROPN
cusj-5588	305	13	)	)	PUNCT
cusj-5588	305	14	are	be	AUX
cusj-5588	305	15	derived	derive	VERB
cusj-5588	305	16	from	from	ADP
cusj-5588	305	17	either	either	CCONJ
cusj-5588	305	18	fetal	fetal	ADJ
cusj-5588	305	19	or	or	CCONJ
cusj-5588	305	20	adult	adult	NOUN
cusj-5588	305	21	neural	neural	ADJ
cusj-5588	305	22	tissue	tissue	NOUN
cusj-5588	305	23	,	,	PUNCT
cusj-5588	305	24	carry	carry	VERB
cusj-5588	305	25	limited	limited	ADJ
cusj-5588	305	26	differentiation	differentiation	NOUN
cusj-5588	305	27	and	and	CCONJ
cusj-5588	305	28	tumour	tumour	NOUN
cusj-5588	305	29	-	-	PUNCT
cusj-5588	305	30	formation	formation	NOUN
cusj-5588	305	31	potentials	potential	NOUN
cusj-5588	305	32	,	,	PUNCT
cusj-5588	305	33	but	but	CCONJ
cusj-5588	305	34	are	be	AUX
cusj-5588	305	35	difficult	difficult	ADJ
cusj-5588	305	36	to	to	PART
cusj-5588	305	37	isolate	isolate	VERB
cusj-5588	305	38	and	and	CCONJ
cusj-5588	305	39	thus	thus	ADV
cusj-5588	305	40	lower	low	ADJ
cusj-5588	305	41	in	in	ADP
cusj-5588	305	42	availability	availability	NOUN
cusj-5588	305	43	.	.	PUNCT
cusj-5588	306	1	ipscs	ipsc	NOUN
cusj-5588	306	2	,	,	PUNCT
cusj-5588	306	3	generated	generate	VERB
cusj-5588	306	4	from	from	ADP
cusj-5588	306	5	somatic	somatic	ADJ
cusj-5588	306	6	3	3	NUM
cusj-5588	306	7	this	this	DET
cusj-5588	306	8	section	section	NOUN
cusj-5588	306	9	is	be	AUX
cusj-5588	306	10	based	base	VERB
cusj-5588	306	11	on	on	ADP
cusj-5588	306	12	readings	reading	NOUN
cusj-5588	306	13	from	from	ADP
cusj-5588	306	14	singh	singh	PROPN
cusj-5588	306	15	et	et	PROPN
cusj-5588	306	16	al	al	PROPN
cusj-5588	306	17	.	.	PUNCT
cusj-5588	307	1	(	(	PUNCT
cusj-5588	307	2	2016	2016	NUM
cusj-5588	307	3	)	)	PUNCT
cusj-5588	307	4	,	,	PUNCT
cusj-5588	307	5	kumar	kumar	PROPN
cusj-5588	307	6	et	et	PROPN
cusj-5588	307	7	al	al	PROPN
cusj-5588	307	8	.	.	PROPN
cusj-5588	308	1	(	(	PUNCT
cusj-5588	308	2	2016	2016	NUM
cusj-5588	308	3	)	)	PUNCT
cusj-5588	308	4	,	,	PUNCT
cusj-5588	308	5	lunn	lunn	PROPN
cusj-5588	308	6	et	et	PROPN
cusj-5588	308	7	al	al	PROPN
cusj-5588	308	8	.	.	PROPN
cusj-5588	309	1	(	(	PUNCT
cusj-5588	309	2	2011	2011	NUM
cusj-5588	309	3	)	)	PUNCT
cusj-5588	309	4	,	,	PUNCT
cusj-5588	309	5	goldman	goldman	NOUN
cusj-5588	309	6	(	(	PUNCT
cusj-5588	309	7	2005	2005	NUM
cusj-5588	309	8	)	)	PUNCT
cusj-5588	309	9	,	,	PUNCT
cusj-5588	309	10	and	and	CCONJ
cusj-5588	309	11	chmielnicki	chmielnicki	NOUN
cusj-5588	309	12	&	&	CCONJ
cusj-5588	309	13	goldman	goldman	PROPN
cusj-5588	309	14	(	(	PUNCT
cusj-5588	309	15	2005	2005	NUM
cusj-5588	309	16	)	)	PUNCT
cusj-5588	309	17	,	,	PUNCT
cusj-5588	309	18	accredited	accredit	VERB
cusj-5588	309	19	in	in	ADP
cusj-5588	309	20	works	work	NOUN
cusj-5588	309	21	cited	cite	VERB
cusj-5588	309	22	tissue	tissue	NOUN
cusj-5588	309	23	and	and	CCONJ
cusj-5588	309	24	reprogrammed	reprogramme	VERB
cusj-5588	309	25	using	use	VERB
cusj-5588	309	26	tfs	tfs	PROPN
cusj-5588	309	27	into	into	ADP
cusj-5588	309	28	embryonic	embryonic	ADJ
cusj-5588	309	29	stem	stem	NOUN
cusj-5588	309	30	cell	cell	NOUN
cusj-5588	309	31	-	-	PUNCT
cusj-5588	309	32	like	like	ADJ
cusj-5588	309	33	states	state	NOUN
cusj-5588	309	34	,	,	PUNCT
cusj-5588	309	35	offer	offer	VERB
cusj-5588	309	36	novel	novel	ADJ
cusj-5588	309	37	sources	source	NOUN
cusj-5588	309	38	of	of	ADP
cusj-5588	309	39	autologous	autologous	ADJ
cusj-5588	309	40	cellular	cellular	ADJ
cusj-5588	309	41	therapy	therapy	NOUN
cusj-5588	309	42	.	.	PUNCT
cusj-5588	310	1	application	application	NOUN
cusj-5588	310	2	of	of	ADP
cusj-5588	310	3	the	the	DET
cusj-5588	310	4	appropriately	appropriately	ADV
cusj-5588	310	5	selected	select	VERB
cusj-5588	310	6	type	type	NOUN
cusj-5588	310	7	of	of	ADP
cusj-5588	310	8	stem	stem	NOUN
cusj-5588	310	9	cell	cell	NOUN
cusj-5588	310	10	to	to	PART
cusj-5588	310	11	treat	treat	VERB
cusj-5588	310	12	neurodegenerative	neurodegenerative	ADJ
cusj-5588	310	13	diseases	disease	NOUN
cusj-5588	310	14	is	be	AUX
cusj-5588	310	15	mediated	mediate	VERB
cusj-5588	310	16	through	through	ADP
cusj-5588	310	17	two	two	NUM
cusj-5588	310	18	primary	primary	ADJ
cusj-5588	310	19	mechanisms	mechanism	NOUN
cusj-5588	310	20	.	.	PUNCT
cusj-5588	311	1	first	first	ADV
cusj-5588	311	2	,	,	PUNCT
cusj-5588	311	3	stem	stem	NOUN
cusj-5588	311	4	cells	cell	NOUN
cusj-5588	311	5	can	can	AUX
cusj-5588	311	6	replace	replace	VERB
cusj-5588	311	7	or	or	CCONJ
cusj-5588	311	8	stabilize	stabilize	VERB
cusj-5588	311	9	neuronal	neuronal	ADJ
cusj-5588	311	10	networks	network	NOUN
cusj-5588	311	11	that	that	PRON
cusj-5588	311	12	experience	experience	VERB
cusj-5588	311	13	both	both	CCONJ
cusj-5588	311	14	widespread	widespread	ADJ
cusj-5588	311	15	or	or	CCONJ
cusj-5588	311	16	specific	specific	ADJ
cusj-5588	311	17	subpopulation	subpopulation	NOUN
cusj-5588	311	18	-	-	PUNCT
cusj-5588	311	19	based	base	VERB
cusj-5588	311	20	neuronal	neuronal	ADJ
cusj-5588	311	21	loss	loss	NOUN
cusj-5588	311	22	.	.	PUNCT
cusj-5588	312	1	second	second	ADJ
cusj-5588	312	2	,	,	PUNCT
cusj-5588	312	3	stem	stem	NOUN
cusj-5588	312	4	cells	cell	NOUN
cusj-5588	312	5	can	can	AUX
cusj-5588	312	6	provide	provide	VERB
cusj-5588	312	7	environmental	environmental	ADJ
cusj-5588	312	8	enrichment	enrichment	NOUN
cusj-5588	312	9	through	through	ADP
cusj-5588	312	10	neurotrophic	neurotrophic	ADJ
cusj-5588	312	11	support	support	NOUN
cusj-5588	312	12	to	to	PART
cusj-5588	312	13	prevent	prevent	VERB
cusj-5588	312	14	further	further	ADJ
cusj-5588	312	15	neuronal	neuronal	ADJ
cusj-5588	312	16	degradation	degradation	NOUN
cusj-5588	312	17	.	.	PUNCT
cusj-5588	313	1	these	these	DET
cusj-5588	313	2	mechanisms	mechanism	NOUN
cusj-5588	313	3	will	will	AUX
cusj-5588	313	4	be	be	AUX
cusj-5588	313	5	discussed	discuss	VERB
cusj-5588	313	6	in	in	ADP
cusj-5588	313	7	the	the	DET
cusj-5588	313	8	context	context	NOUN
cusj-5588	313	9	of	of	ADP
cusj-5588	313	10	specific	specific	ADJ
cusj-5588	313	11	neurodegenerative	neurodegenerative	ADJ
cusj-5588	313	12	diseases	disease	NOUN
cusj-5588	313	13	below	below	ADV
cusj-5588	313	14	.	.	PUNCT
cusj-5588	314	1	following	follow	VERB
cusj-5588	314	2	this	this	DET
cusj-5588	314	3	discussion	discussion	NOUN
cusj-5588	314	4	,	,	PUNCT
cusj-5588	314	5	i	i	PRON
cusj-5588	314	6	’ll	’ll	AUX
cusj-5588	314	7	emphasize	emphasize	VERB
cusj-5588	314	8	that	that	SCONJ
cusj-5588	314	9	the	the	DET
cusj-5588	314	10	focus	focus	NOUN
cusj-5588	314	11	of	of	ADP
cusj-5588	314	12	stem	stem	NOUN
cusj-5588	314	13	cell	cell	NOUN
cusj-5588	314	14	research	research	NOUN
cusj-5588	314	15	should	should	AUX
cusj-5588	314	16	first	first	ADV
cusj-5588	314	17	lie	lie	VERB
cusj-5588	314	18	in	in	ADP
cusj-5588	314	19	exploiting	exploit	VERB
cusj-5588	314	20	its	its	PRON
cusj-5588	314	21	means	mean	NOUN
cusj-5588	314	22	of	of	ADP
cusj-5588	314	23	modelling	model	VERB
cusj-5588	314	24	disease	disease	NOUN
cusj-5588	314	25	pathophysiology	pathophysiology	NOUN
cusj-5588	314	26	and	and	CCONJ
cusj-5588	314	27	providing	provide	VERB
cusj-5588	314	28	an	an	DET
cusj-5588	314	29	in	in	ADP
cusj-5588	314	30	vitro	vitro	X
cusj-5588	314	31	screening	screen	VERB
cusj-5588	314	32	tool	tool	NOUN
cusj-5588	314	33	for	for	ADP
cusj-5588	314	34	screening	screen	VERB
cusj-5588	314	35	efficacy	efficacy	NOUN
cusj-5588	314	36	and	and	CCONJ
cusj-5588	314	37	safety	safety	NOUN
cusj-5588	314	38	of	of	ADP
cusj-5588	314	39	drugs	drug	NOUN
cusj-5588	314	40	,	,	PUNCT
cusj-5588	314	41	then	then	ADV
cusj-5588	314	42	on	on	ADP
cusj-5588	314	43	its	its	PRON
cusj-5588	314	44	direct	direct	ADJ
cusj-5588	314	45	therapeutic	therapeutic	ADJ
cusj-5588	314	46	applications	application	NOUN
cusj-5588	314	47	.	.	PUNCT
cusj-5588	315	1	i	i	PRON
cusj-5588	315	2	’ll	’ll	AUX
cusj-5588	315	3	then	then	ADV
cusj-5588	315	4	highlight	highlight	VERB
cusj-5588	315	5	the	the	DET
cusj-5588	315	6	potential	potential	ADJ
cusj-5588	315	7	ipsc	ipsc	PROPN
cusj-5588	315	8	research	research	PROPN
cusj-5588	315	9	holds	hold	VERB
cusj-5588	315	10	in	in	ADP
cusj-5588	315	11	future	future	ADJ
cusj-5588	315	12	developments	development	NOUN
cusj-5588	315	13	of	of	ADP
cusj-5588	315	14	precision	precision	NOUN
cusj-5588	315	15	medicine	medicine	NOUN
cusj-5588	315	16	.	.	PUNCT
cusj-5588	316	1	alzheimer	alzheimer	PROPN
cusj-5588	316	2	’s	’s	PART
cusj-5588	316	3	complementing	complement	VERB
cusj-5588	316	4	current	current	ADJ
cusj-5588	316	5	pharmacological	pharmacological	ADJ
cusj-5588	316	6	ad	ad	NOUN
cusj-5588	316	7	treatments	treatment	NOUN
cusj-5588	316	8	that	that	PRON
cusj-5588	316	9	regulate	regulate	VERB
cusj-5588	316	10	neurotransmitter	neurotransmitter	NOUN
cusj-5588	316	11	activity	activity	NOUN
cusj-5588	316	12	(	(	PUNCT
cusj-5588	316	13	section	section	NOUN
cusj-5588	316	14	1.1	1.1	NUM
cusj-5588	316	15	)	)	PUNCT
cusj-5588	316	16	,	,	PUNCT
cusj-5588	316	17	stem	stem	NOUN
cusj-5588	316	18	cell	cell	NOUN
cusj-5588	316	19	(	(	PUNCT
cusj-5588	316	20	sc)-based	sc)-base	VERB
cusj-5588	316	21	therapies	therapy	NOUN
cusj-5588	316	22	for	for	ADP
cusj-5588	316	23	ad	ad	NOUN
cusj-5588	316	24	can	can	AUX
cusj-5588	316	25	also	also	ADV
cusj-5588	316	26	help	help	VERB
cusj-5588	316	27	restore	restore	VERB
cusj-5588	316	28	degeneration	degeneration	NOUN
cusj-5588	316	29	and	and	CCONJ
cusj-5588	316	30	loss	loss	NOUN
cusj-5588	316	31	of	of	ADP
cusj-5588	316	32	cholinergic	cholinergic	ADJ
cusj-5588	316	33	neurons	neuron	NOUN
cusj-5588	316	34	,	,	PUNCT
cusj-5588	316	35	and	and	CCONJ
cusj-5588	316	36	increase	increase	VERB
cusj-5588	316	37	levels	level	NOUN
cusj-5588	316	38	of	of	ADP
cusj-5588	316	39	brain	brain	NOUN
cusj-5588	316	40	-	-	PUNCT
cusj-5588	316	41	derived	derive	VERB
cusj-5588	316	42	neurotrophic	neurotrophic	ADJ
cusj-5588	316	43	factor	factor	NOUN
cusj-5588	316	44	(	(	PUNCT
cusj-5588	316	45	bdnf	bdnf	PROPN
cusj-5588	316	46	)	)	PUNCT
cusj-5588	316	47	and	and	CCONJ
cusj-5588	316	48	nerve	nerve	NOUN
cusj-5588	316	49	growth	growth	NOUN
cusj-5588	316	50	factor	factor	NOUN
cusj-5588	316	51	(	(	PUNCT
cusj-5588	316	52	ngf	ngf	NOUN
cusj-5588	316	53	)	)	PUNCT
cusj-5588	316	54	that	that	PRON
cusj-5588	316	55	are	be	AUX
cusj-5588	316	56	lowered	lower	VERB
cusj-5588	316	57	in	in	ADP
cusj-5588	316	58	ad	ad	NOUN
cusj-5588	316	59	.	.	PUNCT
cusj-5588	317	1	in	in	ADP
cusj-5588	317	2	mouse	mouse	NOUN
cusj-5588	317	3	models	model	NOUN
cusj-5588	317	4	,	,	PUNCT
cusj-5588	317	5	combinatorial	combinatorial	ADJ
cusj-5588	317	6	upregulation	upregulation	NOUN
cusj-5588	317	7	of	of	ADP
cusj-5588	317	8	bdnf	bdnf	PROPN
cusj-5588	317	9	with	with	ADP
cusj-5588	317	10	npc	npc	NOUN
cusj-5588	317	11	transplants	transplant	NOUN
cusj-5588	317	12	promoted	promote	VERB
cusj-5588	317	13	neurogenesis	neurogenesis	NOUN
cusj-5588	317	14	and	and	CCONJ
cusj-5588	317	15	protected	protect	VERB
cusj-5588	317	16	neuronal	neuronal	ADJ
cusj-5588	317	17	function	function	NOUN
cusj-5588	317	18	.	.	PUNCT
cusj-5588	318	1	thus	thus	ADV
cusj-5588	318	2	,	,	PUNCT
cusj-5588	318	3	npc	npc	NOUN
cusj-5588	318	4	-	-	PUNCT
cusj-5588	318	5	mediated	mediate	VERB
cusj-5588	318	6	stem	stem	NOUN
cusj-5588	318	7	cell	cell	NOUN
cusj-5588	318	8	-	-	PUNCT
cusj-5588	318	9	based	base	VERB
cusj-5588	318	10	therapy	therapy	NOUN
cusj-5588	318	11	may	may	AUX
cusj-5588	318	12	offer	offer	VERB
cusj-5588	318	13	an	an	DET
cusj-5588	318	14	enhanced	enhanced	ADJ
cusj-5588	318	15	approach	approach	NOUN
cusj-5588	318	16	to	to	ADP
cusj-5588	318	17	preventing	prevent	VERB
cusj-5588	318	18	adassociated	adassociated	ADJ
cusj-5588	318	19	degradation	degradation	NOUN
cusj-5588	318	20	of	of	ADP
cusj-5588	318	21	cholinergic	cholinergic	ADJ
cusj-5588	318	22	synapses	synapsis	NOUN
cusj-5588	318	23	and	and	CCONJ
cusj-5588	318	24	neurons	neuron	NOUN
cusj-5588	318	25	(	(	PUNCT
cusj-5588	318	26	tuszynski	tuszynski	NOUN
cusj-5588	318	27	,	,	PUNCT
cusj-5588	318	28	2007	2007	NUM
cusj-5588	318	29	)	)	PUNCT
cusj-5588	318	30	.	.	PUNCT
cusj-5588	319	1	wang	wang	PROPN
cusj-5588	319	2	et	et	PROPN
cusj-5588	319	3	al	al	PROPN
cusj-5588	319	4	.	.	PROPN
cusj-5588	319	5	(	(	PUNCT
cusj-5588	319	6	2006	2006	NUM
cusj-5588	319	7	)	)	PUNCT
cusj-5588	319	8	compared	compare	VERB
cusj-5588	319	9	transplants	transplant	NOUN
cusj-5588	319	10	of	of	ADP
cusj-5588	319	11	escderived	escderive	VERB
cusj-5588	319	12	nsc	nsc	PROPN
cusj-5588	319	13	to	to	ADP
cusj-5588	319	14	transplants	transplant	NOUN
cusj-5588	319	15	of	of	ADP
cusj-5588	319	16	esc	esc	NOUN
cusj-5588	319	17	alone	alone	ADJ
cusj-5588	319	18	into	into	ADP
cusj-5588	319	19	mouse	mouse	NOUN
cusj-5588	319	20	ad	ad	NOUN
cusj-5588	319	21	models	model	NOUN
cusj-5588	319	22	.	.	PUNCT
cusj-5588	320	1	as	as	SCONJ
cusj-5588	320	2	suggested	suggest	VERB
cusj-5588	320	3	in	in	ADP
cusj-5588	320	4	section	section	NOUN
cusj-5588	320	5	3.0	3.0	NUM
cusj-5588	320	6	,	,	PUNCT
cusj-5588	320	7	esc	esc	NOUN
cusj-5588	320	8	-	-	PUNCT
cusj-5588	320	9	transplanted	transplant	VERB
cusj-5588	320	10	mice	mouse	NOUN
cusj-5588	320	11	developed	develop	VERB
cusj-5588	320	12	teratomas	teratoma	NOUN
cusj-5588	320	13	(	(	PUNCT
cusj-5588	320	14	escs	esc	NOUN
cusj-5588	320	15	:	:	PUNCT
cusj-5588	320	16	unlimited	unlimited	ADJ
cusj-5588	320	17	self	self	NOUN
cusj-5588	320	18	-	-	PUNCT
cusj-5588	320	19	renewal	renewal	NOUN
cusj-5588	320	20	capabilities	capability	NOUN
cusj-5588	320	21	,	,	PUNCT
cusj-5588	320	22	high	high	ADJ
cusj-5588	320	23	risk	risk	NOUN
cusj-5588	320	24	of	of	ADP
cusj-5588	320	25	tumour	tumour	ADJ
cusj-5588	320	26	formation	formation	NOUN
cusj-5588	320	27	)	)	PUNCT
cusj-5588	320	28	,	,	PUNCT
cusj-5588	320	29	while	while	SCONJ
cusj-5588	320	30	transplanted	transplanted	ADJ
cusj-5588	320	31	nscs	nsc	NOUN
cusj-5588	320	32	successfully	successfully	ADV
cusj-5588	320	33	differentiated	differentiate	VERB
cusj-5588	320	34	into	into	ADP
cusj-5588	320	35	stable	stable	ADJ
cusj-5588	320	36	cholinergic	cholinergic	ADJ
cusj-5588	320	37	neurons	neuron	NOUN
cusj-5588	320	38	,	,	PUNCT
cusj-5588	320	39	improving	improve	VERB
cusj-5588	320	40	memory	memory	NOUN
cusj-5588	320	41	and	and	CCONJ
cusj-5588	320	42	learning	learning	NOUN
cusj-5588	320	43	.	.	PUNCT
cusj-5588	321	1	genetically	genetically	ADV
cusj-5588	321	2	modified	modify	VERB
cusj-5588	321	3	nscs	nscs	NOUN
cusj-5588	321	4	for	for	ADP
cusj-5588	321	5	bdnf	bdnf	ADJ
cusj-5588	321	6	expression	expression	NOUN
cusj-5588	321	7	has	have	AUX
cusj-5588	321	8	been	be	AUX
cusj-5588	321	9	shown	show	VERB
cusj-5588	321	10	in	in	ADP
cusj-5588	321	11	many	many	ADJ
cusj-5588	321	12	rodent	rodent	ADJ
cusj-5588	321	13	studies	study	NOUN
cusj-5588	321	14	to	to	PART
cusj-5588	321	15	reduce	reduce	VERB
cusj-5588	321	16	ad	ad	NOUN
cusj-5588	321	17	symptoms	symptom	NOUN
cusj-5588	321	18	(	(	PUNCT
cusj-5588	321	19	lindvall	lindvall	PROPN
cusj-5588	321	20	&	&	CCONJ
cusj-5588	321	21	kokaia	kokaia	PROPN
cusj-5588	321	22	,	,	PUNCT
cusj-5588	321	23	2010	2010	NUM
cusj-5588	321	24	)	)	PUNCT
cusj-5588	321	25	.	.	PUNCT
cusj-5588	322	1	in	in	ADP
cusj-5588	322	2	these	these	DET
cusj-5588	322	3	mouse	mouse	NOUN
cusj-5588	322	4	models	model	NOUN
cusj-5588	322	5	,	,	PUNCT
cusj-5588	322	6	increased	increase	VERB
cusj-5588	322	7	hippocampal	hippocampal	ADJ
cusj-5588	322	8	synaptic	synaptic	ADJ
cusj-5588	322	9	density	density	NOUN
cusj-5588	322	10	,	,	PUNCT
cusj-5588	322	11	increased	increase	VERB
cusj-5588	322	12	cognitive	cognitive	ADJ
cusj-5588	322	13	function	function	NOUN
cusj-5588	322	14	,	,	PUNCT
cusj-5588	322	15	and	and	CCONJ
cusj-5588	322	16	enhanced	enhance	VERB
cusj-5588	322	17	cell	cell	NOUN
cusj-5588	322	18	-	-	PUNCT
cusj-5588	322	19	cell	cell	NOUN
cusj-5588	322	20	synaptic	synaptic	ADJ
cusj-5588	322	21	communication	communication	NOUN
cusj-5588	322	22	,	,	PUNCT
cusj-5588	322	23	as	as	SCONJ
cusj-5588	322	24	associated	associate	VERB
cusj-5588	322	25	with	with	ADP
cusj-5588	322	26	increased	increase	VERB
cusj-5588	322	27	bdnf	bdnf	ADJ
cusj-5588	322	28	expression	expression	NOUN
cusj-5588	322	29	(	(	PUNCT
cusj-5588	322	30	blurton	blurton	NOUN
cusj-5588	322	31	-	-	PUNCT
cusj-5588	322	32	jones	jones	PROPN
cusj-5588	322	33	et	et	PROPN
cusj-5588	322	34	al	al	PROPN
cusj-5588	322	35	.	.	PROPN
cusj-5588	322	36	,	,	PUNCT
cusj-5588	322	37	2009	2009	NUM
cusj-5588	322	38	;	;	PUNCT
cusj-5588	322	39	li	li	PROPN
cusj-5588	322	40	et	et	PROPN
cusj-5588	322	41	al	al	PROPN
cusj-5588	322	42	.	.	PROPN
cusj-5588	322	43	,	,	PUNCT
cusj-5588	322	44	2009	2009	NUM
cusj-5588	322	45	;	;	PUNCT
cusj-5588	322	46	xuan	xuan	PROPN
cusj-5588	322	47	et	et	PROPN
cusj-5588	322	48	al	al	PROPN
cusj-5588	322	49	.	.	PROPN
cusj-5588	322	50	,	,	PUNCT
cusj-5588	322	51	2008	2008	NUM
cusj-5588	322	52	)	)	PUNCT
cusj-5588	322	53	.	.	PUNCT
cusj-5588	323	1	ngf	ngf	PROPN
cusj-5588	323	2	has	have	AUX
cusj-5588	323	3	also	also	ADV
cusj-5588	323	4	been	be	AUX
cusj-5588	323	5	implicated	implicate	VERB
cusj-5588	323	6	in	in	ADP
cusj-5588	323	7	preventing	prevent	VERB
cusj-5588	323	8	neuro	neuro	NOUN
cusj-5588	323	9	-	-	PUNCT
cusj-5588	323	10	degeneration	degeneration	NOUN
cusj-5588	323	11	and	and	CCONJ
cusj-5588	323	12	reducing	reduce	VERB
cusj-5588	323	13	amyloid	amyloid	NOUN
cusj-5588	323	14	toxicity	toxicity	NOUN
cusj-5588	323	15	12	12	NUM
cusj-5588	323	16	_	_	PUNCT
cusj-5588	324	1	_	_	PUNCT
cusj-5588	325	1	_	_	PUNCT
cusj-5588	326	1	_	_	PUNCT
cusj-5588	327	1	_	_	PUNCT
cusj-5588	328	1	_	_	PUNCT
cusj-5588	329	1	_	_	PUNCT
cusj-5588	330	1	_	_	PUNCT
cusj-5588	331	1	_	_	PUNCT
cusj-5588	332	1	_	_	PUNCT
cusj-5588	333	1	_	_	PUNCT
cusj-5588	334	1	_	_	PUNCT
cusj-5588	335	1	_	_	PUNCT
cusj-5588	336	1	_	_	PUNCT
cusj-5588	337	1	_	_	PUNCT
cusj-5588	338	1	_	_	PUNCT
cusj-5588	339	1	_	_	PUNCT
cusj-5588	340	1	_	_	PUNCT
cusj-5588	341	1	_	_	PUNCT
cusj-5588	342	1	_	_	PUNCT
cusj-5588	343	1	_	_	PUNCT
cusj-5588	344	1	_	_	PUNCT
cusj-5588	345	1	_	_	PUNCT
cusj-5588	346	1	_	_	PUNCT
cusj-5588	347	1	_	_	PUNCT
cusj-5588	348	1	_	_	PUNCT
cusj-5588	349	1	_	_	PUNCT
cusj-5588	350	1	_	_	PUNCT
cusj-5588	351	1	_	_	PUNCT
cusj-5588	352	1	_	_	PUNCT
cusj-5588	353	1	_	_	PUNCT
cusj-5588	354	1	_	_	PUNCT
cusj-5588	355	1	_	_	PUNCT
cusj-5588	356	1	_	_	PUNCT
cusj-5588	357	1	_	_	PUNCT
cusj-5588	358	1	_	_	PUNCT
cusj-5588	359	1	_	_	PUNCT
cusj-5588	360	1	_	_	PUNCT
cusj-5588	361	1	_	_	PUNCT
cusj-5588	362	1	_	_	PUNCT
cusj-5588	363	1	_	_	PUNCT
cusj-5588	364	1	_	_	PUNCT
cusj-5588	365	1	_	_	PUNCT
cusj-5588	366	1	_	_	PUNCT
cusj-5588	367	1	_	_	PUNCT
cusj-5588	368	1	_	_	PUNCT
cusj-5588	369	1	_	_	PUNCT
cusj-5588	370	1	_	_	PUNCT
cusj-5588	371	1	_	_	PUNCT
cusj-5588	372	1	_	_	PUNCT
cusj-5588	373	1	_	_	PUNCT
cusj-5588	374	1	_	_	PUNCT
cusj-5588	375	1	_	_	PUNCT
cusj-5588	376	1	_	_	PUNCT
cusj-5588	377	1	_	_	PUNCT
cusj-5588	378	1	_	_	PUNCT
cusj-5588	379	1	_	_	PUNCT
cusj-5588	380	1	_	_	PUNCT
cusj-5588	381	1	_	_	PUNCT
cusj-5588	382	1	_	_	PUNCT
cusj-5588	383	1	_	_	PUNCT
cusj-5588	384	1	_	_	PUNCT
cusj-5588	385	1	_	_	PUNCT
cusj-5588	386	1	_	_	PUNCT
cusj-5588	387	1	_	_	PUNCT
cusj-5588	388	1	_	_	PUNCT
cusj-5588	389	1	_	_	PUNCT
cusj-5588	390	1	_	_	PUNCT
cusj-5588	391	1	_	_	PUNCT
cusj-5588	392	1	_	_	PUNCT
cusj-5588	393	1	_	_	PUNCT
cusj-5588	394	1	_	_	PUNCT
cusj-5588	395	1	_	_	PUNCT
cusj-5588	396	1	_	_	PUNCT
cusj-5588	397	1	_	_	PUNCT
cusj-5588	398	1	_	_	PUNCT
cusj-5588	399	1	_	_	PUNCT
cusj-5588	400	1	_	_	PUNCT
cusj-5588	401	1	_	_	PUNCT
cusj-5588	402	1	_	_	PUNCT
cusj-5588	402	2	cusj	cusj	ADJ
cusj-5588	402	3	2018	2018	NUM
cusj-5588	402	4	(	(	PUNCT
cusj-5588	402	5	tuszynski	tuszynski	PROPN
cusj-5588	402	6	et	et	PROPN
cusj-5588	402	7	al	al	PROPN
cusj-5588	402	8	.	.	PROPN
cusj-5588	402	9	,	,	PUNCT
cusj-5588	402	10	2007	2007	NUM
cusj-5588	402	11	)	)	PUNCT
cusj-5588	402	12	.	.	PUNCT
cusj-5588	403	1	in	in	ADP
cusj-5588	403	2	addition	addition	NOUN
cusj-5588	403	3	to	to	ADP
cusj-5588	403	4	aav2	aav2	PROPN
cusj-5588	403	5	-	-	PUNCT
cusj-5588	403	6	mediated	mediate	VERB
cusj-5588	403	7	gene	gene	NOUN
cusj-5588	403	8	therapy	therapy	NOUN
cusj-5588	403	9	techniques	technique	NOUN
cusj-5588	403	10	discussed	discuss	VERB
cusj-5588	403	11	in	in	ADP
cusj-5588	403	12	section	section	NOUN
cusj-5588	403	13	2.1.1	2.1.1	NUM
cusj-5588	403	14	,	,	PUNCT
cusj-5588	403	15	autologous	autologous	ADJ
cusj-5588	403	16	fibroblasts	fibroblast	NOUN
cusj-5588	403	17	genetically	genetically	ADV
cusj-5588	403	18	modified	modify	VERB
cusj-5588	403	19	to	to	PART
cusj-5588	403	20	express	express	VERB
cusj-5588	403	21	ngf	ngf	ADV
cusj-5588	403	22	implanted	implant	VERB
cusj-5588	403	23	into	into	ADP
cusj-5588	403	24	patient	patient	ADJ
cusj-5588	403	25	forebrains	forebrain	NOUN
cusj-5588	403	26	have	have	AUX
cusj-5588	403	27	been	be	AUX
cusj-5588	403	28	found	find	VERB
cusj-5588	403	29	to	to	PART
cusj-5588	403	30	slow	slow	VERB
cusj-5588	403	31	rates	rate	NOUN
cusj-5588	403	32	of	of	ADP
cusj-5588	403	33	cognitive	cognitive	ADJ
cusj-5588	403	34	decline	decline	NOUN
cusj-5588	403	35	in	in	ADP
cusj-5588	403	36	an	an	DET
cusj-5588	403	37	open	open	ADJ
cusj-5588	403	38	-	-	PUNCT
cusj-5588	403	39	label	label	NOUN
cusj-5588	403	40	phase	phase	NOUN
cusj-5588	403	41	1	1	NUM
cusj-5588	403	42	clinical	clinical	ADJ
cusj-5588	403	43	trial	trial	NOUN
cusj-5588	403	44	(	(	PUNCT
cusj-5588	403	45	tuszynski	tuszynski	NOUN
cusj-5588	403	46	et	et	PROPN
cusj-5588	403	47	al	al	PROPN
cusj-5588	403	48	.	.	PROPN
cusj-5588	403	49	,	,	PUNCT
cusj-5588	403	50	2005	2005	NUM
cusj-5588	403	51	)	)	PUNCT
cusj-5588	403	52	.	.	PUNCT
cusj-5588	404	1	however	however	ADV
cusj-5588	404	2	,	,	PUNCT
cusj-5588	404	3	fibroblasts	fibroblast	NOUN
cusj-5588	404	4	are	be	AUX
cusj-5588	404	5	immobile	immobile	ADJ
cusj-5588	404	6	and	and	CCONJ
cusj-5588	404	7	can	can	AUX
cusj-5588	404	8	not	not	PART
cusj-5588	404	9	slow	slow	VERB
cusj-5588	404	10	degeneration	degeneration	NOUN
cusj-5588	404	11	across	across	ADP
cusj-5588	404	12	large	large	ADJ
cusj-5588	404	13	brain	brain	NOUN
cusj-5588	404	14	regions	region	NOUN
cusj-5588	404	15	.	.	PUNCT
cusj-5588	405	1	transplanted	transplant	VERB
cusj-5588	405	2	stem	stem	NOUN
cusj-5588	405	3	cells	cell	NOUN
cusj-5588	405	4	can	can	AUX
cusj-5588	405	5	efficiently	efficiently	ADV
cusj-5588	405	6	migrate	migrate	VERB
cusj-5588	405	7	and	and	CCONJ
cusj-5588	405	8	release	release	VERB
cusj-5588	405	9	growth	growth	NOUN
cusj-5588	405	10	factors	factor	NOUN
cusj-5588	405	11	to	to	ADP
cusj-5588	405	12	many	many	ADJ
cusj-5588	405	13	damaged	damaged	ADJ
cusj-5588	405	14	sites	site	NOUN
cusj-5588	405	15	,	,	PUNCT
cusj-5588	405	16	but	but	CCONJ
cusj-5588	405	17	their	their	PRON
cusj-5588	405	18	use	use	NOUN
cusj-5588	405	19	in	in	ADP
cusj-5588	405	20	ad	ad	NOUN
cusj-5588	405	21	treatment	treatment	NOUN
cusj-5588	405	22	has	have	VERB
cusj-5588	405	23	yet	yet	ADV
cusj-5588	405	24	to	to	PART
cusj-5588	405	25	be	be	AUX
cusj-5588	405	26	fully	fully	ADV
cusj-5588	405	27	explored	explore	VERB
cusj-5588	405	28	.	.	PUNCT
cusj-5588	406	1	another	another	DET
cusj-5588	406	2	technique	technique	NOUN
cusj-5588	406	3	to	to	PART
cusj-5588	406	4	increase	increase	VERB
cusj-5588	406	5	ngf	ngf	ADJ
cusj-5588	406	6	release	release	NOUN
cusj-5588	406	7	to	to	PART
cusj-5588	406	8	treat	treat	VERB
cusj-5588	406	9	ad	ad	NOUN
cusj-5588	406	10	is	be	AUX
cusj-5588	406	11	with	with	ADP
cusj-5588	406	12	encapsulated	encapsulate	VERB
cusj-5588	406	13	cell	cell	NOUN
cusj-5588	406	14	biodelivery	biodelivery	NOUN
cusj-5588	406	15	(	(	PUNCT
cusj-5588	406	16	ecb	ecb	NOUN
cusj-5588	406	17	)	)	PUNCT
cusj-5588	406	18	implants	implant	NOUN
cusj-5588	406	19	,	,	PUNCT
cusj-5588	406	20	for	for	ADP
cusj-5588	406	21	which	which	PRON
cusj-5588	406	22	the	the	DET
cusj-5588	406	23	first	first	ADJ
cusj-5588	406	24	clinical	clinical	ADJ
cusj-5588	406	25	trial	trial	NOUN
cusj-5588	406	26	was	be	AUX
cusj-5588	406	27	conducted	conduct	VERB
cusj-5588	406	28	in	in	ADP
cusj-5588	406	29	2008	2008	NUM
cusj-5588	406	30	by	by	ADP
cusj-5588	406	31	the	the	DET
cusj-5588	406	32	danish	danish	ADJ
cusj-5588	406	33	company	company	NOUN
cusj-5588	406	34	nsgene	nsgene	NOUN
cusj-5588	406	35	.	.	PUNCT
cusj-5588	407	1	encapsulated	encapsulate	VERB
cusj-5588	407	2	retinal	retinal	ADJ
cusj-5588	407	3	pigment	pigment	ADJ
cusj-5588	407	4	epithelial	epithelial	ADJ
cusj-5588	407	5	cells	cell	NOUN
cusj-5588	407	6	releasing	release	VERB
cusj-5588	407	7	ngf	ngf	ADV
cusj-5588	407	8	were	be	AUX
cusj-5588	407	9	implanted	implant	VERB
cusj-5588	407	10	into	into	ADP
cusj-5588	407	11	the	the	DET
cusj-5588	407	12	basal	basal	NOUN
cusj-5588	407	13	forebrains	forebrain	NOUN
cusj-5588	407	14	of	of	ADP
cusj-5588	407	15	six	six	NUM
cusj-5588	407	16	ad	ad	NOUN
cusj-5588	407	17	patients	patient	NOUN
cusj-5588	407	18	(	(	PUNCT
cusj-5588	407	19	wahlberg	wahlberg	PROPN
cusj-5588	407	20	et	et	PROPN
cusj-5588	407	21	al	al	PROPN
cusj-5588	407	22	.	.	PROPN
cusj-5588	407	23	,	,	PUNCT
cusj-5588	407	24	2012	2012	NUM
cusj-5588	407	25	)	)	PUNCT
cusj-5588	407	26	.	.	PUNCT
cusj-5588	408	1	at	at	ADP
cusj-5588	408	2	12	12	NUM
cusj-5588	408	3	months	month	NOUN
cusj-5588	408	4	,	,	PUNCT
cusj-5588	408	5	implants	implant	NOUN
cusj-5588	408	6	were	be	AUX
cusj-5588	408	7	retrieved	retrieve	VERB
cusj-5588	408	8	and	and	CCONJ
cusj-5588	408	9	low	low	ADJ
cusj-5588	408	10	but	but	CCONJ
cusj-5588	408	11	persistent	persistent	ADJ
cusj-5588	408	12	ngf	ngf	ADJ
cusj-5588	408	13	secretion	secretion	NOUN
cusj-5588	408	14	was	be	AUX
cusj-5588	408	15	detected	detect	VERB
cusj-5588	408	16	in	in	ADP
cusj-5588	408	17	half	half	NOUN
cusj-5588	408	18	of	of	ADP
cusj-5588	408	19	the	the	DET
cusj-5588	408	20	subjects	subject	NOUN
cusj-5588	408	21	.	.	PUNCT
cusj-5588	409	1	thus	thus	ADV
cusj-5588	409	2	,	,	PUNCT
cusj-5588	409	3	both	both	PRON
cusj-5588	409	4	ecb	ecb	NOUN
cusj-5588	409	5	implantation	implantation	NOUN
cusj-5588	409	6	and	and	CCONJ
cusj-5588	409	7	stem	stem	NOUN
cusj-5588	409	8	cell	cell	NOUN
cusj-5588	409	9	-	-	PUNCT
cusj-5588	409	10	based	base	VERB
cusj-5588	409	11	gene	gene	NOUN
cusj-5588	409	12	therapy	therapy	NOUN
cusj-5588	409	13	may	may	AUX
cusj-5588	409	14	provide	provide	VERB
cusj-5588	409	15	future	future	ADJ
cusj-5588	409	16	methods	method	NOUN
cusj-5588	409	17	for	for	ADP
cusj-5588	409	18	enhancing	enhance	VERB
cusj-5588	409	19	ngf	ngf	ADJ
cusj-5588	409	20	expression	expression	NOUN
cusj-5588	409	21	to	to	PART
cusj-5588	409	22	counteract	counteract	VERB
cusj-5588	409	23	cholinergic	cholinergic	ADJ
cusj-5588	409	24	neuronal	neuronal	ADJ
cusj-5588	409	25	death	death	NOUN
cusj-5588	409	26	.	.	PUNCT
cusj-5588	410	1	although	although	SCONJ
cusj-5588	410	2	nsc	nsc	PROPN
cusj-5588	410	3	transplantations	transplantation	NOUN
cusj-5588	410	4	into	into	ADP
cusj-5588	410	5	the	the	DET
cusj-5588	410	6	adult	adult	NOUN
cusj-5588	410	7	forebrain	forebrain	NOUN
cusj-5588	410	8	of	of	ADP
cusj-5588	410	9	patients	patient	NOUN
cusj-5588	410	10	may	may	AUX
cusj-5588	410	11	be	be	AUX
cusj-5588	410	12	able	able	ADJ
cusj-5588	410	13	to	to	PART
cusj-5588	410	14	increase	increase	VERB
cusj-5588	410	15	cholinergic	cholinergic	ADJ
cusj-5588	410	16	and	and	CCONJ
cusj-5588	410	17	cognitive	cognitive	ADJ
cusj-5588	410	18	aptitude	aptitude	NOUN
cusj-5588	410	19	,	,	PUNCT
cusj-5588	410	20	they	they	PRON
cusj-5588	410	21	are	be	AUX
cusj-5588	410	22	unable	unable	ADJ
cusj-5588	410	23	to	to	PART
cusj-5588	410	24	target	target	VERB
cusj-5588	410	25	the	the	DET
cusj-5588	410	26	main	main	ADJ
cusj-5588	410	27	molecular	molecular	ADJ
cusj-5588	410	28	cause	cause	NOUN
cusj-5588	410	29	of	of	ADP
cusj-5588	410	30	the	the	DET
cusj-5588	410	31	disease	disease	NOUN
cusj-5588	410	32	:	:	PUNCT
cusj-5588	410	33	accumulation	accumulation	NOUN
cusj-5588	410	34	of	of	ADP
cusj-5588	410	35	β	β	NOUN
cusj-5588	410	36	-	-	ADJ
cusj-5588	410	37	amyloid	amyloid	ADJ
cusj-5588	410	38	plaques	plaque	NOUN
cusj-5588	410	39	(	(	PUNCT
cusj-5588	410	40	blurtonjones	blurtonjone	NOUN
cusj-5588	410	41	et	et	PROPN
cusj-5588	410	42	al	al	PROPN
cusj-5588	410	43	.	.	PROPN
cusj-5588	410	44	,	,	PUNCT
cusj-5588	410	45	2009	2009	NUM
cusj-5588	410	46	)	)	PUNCT
cusj-5588	410	47	.	.	PUNCT
cusj-5588	411	1	nonetheless	nonetheless	ADV
cusj-5588	411	2	,	,	PUNCT
cusj-5588	411	3	the	the	DET
cusj-5588	411	4	ability	ability	NOUN
cusj-5588	411	5	of	of	ADP
cusj-5588	411	6	nsc	nsc	PROPN
cusj-5588	411	7	transplants	transplant	NOUN
cusj-5588	411	8	to	to	PART
cusj-5588	411	9	enhance	enhance	VERB
cusj-5588	411	10	cholinergic	cholinergic	ADJ
cusj-5588	411	11	function	function	NOUN
cusj-5588	411	12	,	,	PUNCT
cusj-5588	411	13	synaptic	synaptic	ADJ
cusj-5588	411	14	transmission	transmission	NOUN
cusj-5588	411	15	,	,	PUNCT
cusj-5588	411	16	and	and	CCONJ
cusj-5588	411	17	neuronal	neuronal	ADJ
cusj-5588	411	18	function	function	NOUN
cusj-5588	411	19	is	be	AUX
cusj-5588	411	20	suggested	suggest	VERB
cusj-5588	411	21	by	by	ADP
cusj-5588	411	22	animal	animal	NOUN
cusj-5588	411	23	studies	study	NOUN
cusj-5588	411	24	and	and	CCONJ
cusj-5588	411	25	replicated	replicate	VERB
cusj-5588	411	26	by	by	ADP
cusj-5588	411	27	initial	initial	ADJ
cusj-5588	411	28	clinical	clinical	ADJ
cusj-5588	411	29	trials	trial	NOUN
cusj-5588	411	30	(	(	PUNCT
cusj-5588	411	31	tuszynski	tuszynski	PROPN
cusj-5588	411	32	,	,	PUNCT
cusj-5588	411	33	2007	2007	NUM
cusj-5588	411	34	)	)	PUNCT
cusj-5588	411	35	.	.	PUNCT
cusj-5588	412	1	combining	combine	VERB
cusj-5588	412	2	growth	growth	NOUN
cusj-5588	412	3	factor	factor	NOUN
cusj-5588	412	4	overexpression	overexpression	NOUN
cusj-5588	412	5	with	with	ADP
cusj-5588	412	6	npcs	npc	NOUN
cusj-5588	412	7	’	'	PUNCT
cusj-5588	412	8	ability	ability	NOUN
cusj-5588	412	9	to	to	PART
cusj-5588	412	10	integrate	integrate	VERB
cusj-5588	412	11	across	across	ADP
cusj-5588	412	12	many	many	ADJ
cusj-5588	412	13	neural	neural	ADJ
cusj-5588	412	14	networks	network	NOUN
cusj-5588	412	15	thus	thus	ADV
cusj-5588	412	16	presents	present	VERB
cusj-5588	412	17	an	an	DET
cusj-5588	412	18	exciting	exciting	ADJ
cusj-5588	412	19	potential	potential	NOUN
cusj-5588	412	20	for	for	ADP
cusj-5588	412	21	limiting	limit	VERB
cusj-5588	412	22	ad	ad	NOUN
cusj-5588	412	23	pathogenesis	pathogenesis	NOUN
cusj-5588	412	24	.	.	PUNCT
cusj-5588	413	1	continued	continue	VERB
cusj-5588	413	2	research	research	NOUN
cusj-5588	413	3	must	must	AUX
cusj-5588	413	4	be	be	AUX
cusj-5588	413	5	conducted	conduct	VERB
cusj-5588	413	6	before	before	ADP
cusj-5588	413	7	established	establish	VERB
cusj-5588	413	8	sc	sc	PROPN
cusj-5588	413	9	-	-	PUNCT
cusj-5588	413	10	based	base	VERB
cusj-5588	413	11	treatments	treatment	NOUN
cusj-5588	413	12	can	can	AUX
cusj-5588	413	13	be	be	AUX
cusj-5588	413	14	developed	develop	VERB
cusj-5588	413	15	for	for	ADP
cusj-5588	413	16	ad	ad	NOUN
cusj-5588	413	17	therapy	therapy	NOUN
cusj-5588	413	18	.	.	PUNCT
cusj-5588	414	1	parkinson	parkinson	NOUN
cusj-5588	414	2	’s	’s	PART
cusj-5588	414	3	earlier	early	ADJ
cusj-5588	414	4	open	open	ADJ
cusj-5588	414	5	-	-	PUNCT
cusj-5588	414	6	label	label	NOUN
cusj-5588	414	7	studies	study	NOUN
cusj-5588	414	8	of	of	ADP
cusj-5588	414	9	human	human	ADJ
cusj-5588	414	10	fetal	fetal	ADJ
cusj-5588	414	11	ventral	ventral	ADJ
cusj-5588	414	12	mesencehalic	mesencehalic	ADJ
cusj-5588	414	13	tissue	tissue	NOUN
cusj-5588	414	14	(	(	PUNCT
cusj-5588	414	15	hfvm	hfvm	NOUN
cusj-5588	414	16	)	)	PUNCT
cusj-5588	414	17	transplants	transplant	NOUN
cusj-5588	414	18	in	in	ADP
cusj-5588	414	19	parkinson	parkinson	NOUN
cusj-5588	414	20	’s	’s	PART
cusj-5588	414	21	patients	patient	NOUN
cusj-5588	414	22	yielded	yield	VERB
cusj-5588	414	23	successful	successful	ADJ
cusj-5588	414	24	long	long	ADJ
cusj-5588	414	25	-	-	PUNCT
cusj-5588	414	26	term	term	NOUN
cusj-5588	414	27	pd	pd	NOUN
cusj-5588	414	28	symptomatic	symptomatic	ADJ
cusj-5588	414	29	relief	relief	NOUN
cusj-5588	414	30	,	,	PUNCT
cusj-5588	414	31	but	but	CCONJ
cusj-5588	414	32	these	these	DET
cusj-5588	414	33	results	result	NOUN
cusj-5588	414	34	failed	fail	VERB
cusj-5588	414	35	to	to	PART
cusj-5588	414	36	replicate	replicate	VERB
cusj-5588	414	37	in	in	ADP
cusj-5588	414	38	subsequent	subsequent	ADJ
cusj-5588	414	39	placebo	placebo	NOUN
cusj-5588	414	40	-	-	PUNCT
cusj-5588	414	41	controlled	control	VERB
cusj-5588	414	42	,	,	PUNCT
cusj-5588	414	43	double	double	ADJ
cusj-5588	414	44	-	-	PUNCT
cusj-5588	414	45	blind	blind	ADJ
cusj-5588	414	46	trials	trial	NOUN
cusj-5588	414	47	(	(	PUNCT
cusj-5588	414	48	brundin	brundin	VERB
cusj-5588	414	49	et	et	PROPN
cusj-5588	414	50	al	al	PROPN
cusj-5588	414	51	.	.	PROPN
cusj-5588	414	52	,	,	PUNCT
cusj-5588	414	53	2010	2010	NUM
cusj-5588	414	54	)	)	PUNCT
cusj-5588	414	55	.	.	PUNCT
cusj-5588	415	1	success	success	NOUN
cusj-5588	415	2	has	have	AUX
cusj-5588	415	3	been	be	AUX
cusj-5588	415	4	observed	observe	VERB
cusj-5588	415	5	in	in	ADP
cusj-5588	415	6	using	use	VERB
cusj-5588	415	7	genetically	genetically	ADV
cusj-5588	415	8	modified	modify	VERB
cusj-5588	415	9	escs	esc	NOUN
cusj-5588	415	10	and	and	CCONJ
cusj-5588	415	11	ipscs	ipscs	NOUN
cusj-5588	415	12	to	to	PART
cusj-5588	415	13	derive	derive	VERB
cusj-5588	415	14	neurons	neuron	NOUN
cusj-5588	415	15	with	with	ADP
cusj-5588	415	16	the	the	DET
cusj-5588	415	17	dopaminergic	dopaminergic	ADJ
cusj-5588	415	18	(	(	PUNCT
cusj-5588	415	19	da	da	ADJ
cusj-5588	415	20	)	)	PUNCT
cusj-5588	415	21	phenotype	phenotype	NOUN
cusj-5588	415	22	,	,	PUNCT
cusj-5588	415	23	but	but	CCONJ
cusj-5588	415	24	these	these	DET
cusj-5588	415	25	techniques	technique	NOUN
cusj-5588	415	26	have	have	AUX
cusj-5588	415	27	not	not	PART
cusj-5588	415	28	yet	yet	ADV
cusj-5588	415	29	been	be	AUX
cusj-5588	415	30	translated	translate	VERB
cusj-5588	415	31	into	into	ADP
cusj-5588	415	32	clinical	clinical	ADJ
cusj-5588	415	33	studies	study	NOUN
cusj-5588	415	34	.	.	PUNCT
cusj-5588	416	1	clinical	clinical	ADJ
cusj-5588	416	2	trials	trial	NOUN
cusj-5588	416	3	using	use	VERB
cusj-5588	416	4	hfvm	hfvm	NOUN
cusj-5588	416	5	tissue	tissue	NOUN
cusj-5588	416	6	transplants	transplant	NOUN
cusj-5588	416	7	in	in	ADP
cusj-5588	416	8	the	the	DET
cusj-5588	416	9	1990s	1990	NOUN
cusj-5588	416	10	(	(	PUNCT
cusj-5588	416	11	madrazo	madrazo	PROPN
cusj-5588	416	12	et	et	PROPN
cusj-5588	416	13	al	al	PROPN
cusj-5588	416	14	.	.	PROPN
cusj-5588	416	15	,	,	PUNCT
cusj-5588	416	16	1988	1988	NUM
cusj-5588	416	17	;	;	PUNCT
cusj-5588	416	18	lindvall	lindvall	PROPN
cusj-5588	416	19	et	et	PROPN
cusj-5588	416	20	al	al	PROPN
cusj-5588	416	21	.	.	PROPN
cusj-5588	416	22	,	,	PUNCT
cusj-5588	416	23	1990	1990	NUM
cusj-5588	416	24	)	)	PUNCT
cusj-5588	416	25	found	find	VERB
cusj-5588	416	26	impressive	impressive	ADJ
cusj-5588	416	27	restoration	restoration	NOUN
cusj-5588	416	28	of	of	ADP
cusj-5588	416	29	dopaminergic	dopaminergic	ADJ
cusj-5588	416	30	neurotransmission	neurotransmission	NOUN
cusj-5588	416	31	and	and	CCONJ
cusj-5588	416	32	motor	motor	NOUN
cusj-5588	416	33	-	-	PUNCT
cusj-5588	416	34	symptom	symptom	NOUN
cusj-5588	416	35	alleviation	alleviation	NOUN
cusj-5588	416	36	.	.	PUNCT
cusj-5588	417	1	in	in	ADP
cusj-5588	417	2	these	these	DET
cusj-5588	417	3	open	open	ADJ
cusj-5588	417	4	-	-	PUNCT
cusj-5588	417	5	label	label	NOUN
cusj-5588	417	6	clinical	clinical	ADJ
cusj-5588	417	7	studies	study	NOUN
cusj-5588	417	8	,	,	PUNCT
cusj-5588	417	9	pet	pet	ADJ
cusj-5588	417	10	scans	scan	NOUN
cusj-5588	417	11	showed	show	VERB
cusj-5588	417	12	long	long	ADV
cusj-5588	417	13	-	-	PUNCT
cusj-5588	417	14	lasting	last	VERB
cusj-5588	417	15	evidence	evidence	NOUN
cusj-5588	417	16	of	of	ADP
cusj-5588	417	17	functionally	functionally	ADV
cusj-5588	417	18	-	-	PUNCT
cusj-5588	417	19	integrated	integrate	VERB
cusj-5588	417	20	dopaminergic	dopaminergic	ADJ
cusj-5588	417	21	neurons	neuron	NOUN
cusj-5588	417	22	forming	form	VERB
cusj-5588	417	23	from	from	ADP
cusj-5588	417	24	transplanted	transplanted	ADJ
cusj-5588	417	25	tissue	tissue	NOUN
cusj-5588	417	26	,	,	PUNCT
cusj-5588	417	27	restored	restore	VERB
cusj-5588	417	28	da	da	ADJ
cusj-5588	417	29	release	release	NOUN
cusj-5588	417	30	in	in	ADP
cusj-5588	417	31	vivo	vivo	NOUN
cusj-5588	417	32	,	,	PUNCT
cusj-5588	417	33	and	and	CCONJ
cusj-5588	417	34	reactivation	reactivation	NOUN
cusj-5588	417	35	of	of	ADP
cusj-5588	417	36	cortical	cortical	ADJ
cusj-5588	417	37	motor	motor	NOUN
cusj-5588	417	38	areas	area	NOUN
cusj-5588	417	39	.	.	PUNCT
cusj-5588	418	1	however	however	ADV
cusj-5588	418	2	,	,	PUNCT
cusj-5588	418	3	the	the	DET
cusj-5588	418	4	design	design	NOUN
cusj-5588	418	5	of	of	ADP
cusj-5588	418	6	these	these	DET
cusj-5588	418	7	open	open	ADJ
cusj-5588	418	8	-	-	PUNCT
cusj-5588	418	9	label	label	NOUN
cusj-5588	418	10	trials	trial	NOUN
cusj-5588	418	11	contains	contain	VERB
cusj-5588	418	12	significant	significant	ADJ
cusj-5588	418	13	bias	bias	NOUN
cusj-5588	418	14	and	and	CCONJ
cusj-5588	418	15	thus	thus	ADV
cusj-5588	418	16	deserve	deserve	VERB
cusj-5588	418	17	cautious	cautious	ADJ
cusj-5588	418	18	interpretation	interpretation	NOUN
cusj-5588	418	19	.	.	PUNCT
cusj-5588	419	1	further	far	ADV
cusj-5588	419	2	,	,	PUNCT
cusj-5588	419	3	the	the	DET
cusj-5588	419	4	occurrence	occurrence	NOUN
cusj-5588	419	5	of	of	ADP
cusj-5588	419	6	recurring	recur	VERB
cusj-5588	419	7	graft	graft	NOUN
cusj-5588	419	8	-	-	PUNCT
cusj-5588	419	9	induced	induce	VERB
cusj-5588	419	10	dyskinesias	dyskinesia	NOUN
cusj-5588	419	11	(	(	PUNCT
cusj-5588	419	12	gids	gids	PROPN
cusj-5588	419	13	)	)	PUNCT
cusj-5588	419	14	in	in	ADP
cusj-5588	419	15	consequent	consequent	ADJ
cusj-5588	419	16	double	double	ADJ
cusj-5588	419	17	-	-	PUNCT
cusj-5588	419	18	blind	blind	ADJ
cusj-5588	419	19	trials	trial	NOUN
cusj-5588	419	20	,	,	PUNCT
cusj-5588	419	21	in	in	ADP
cusj-5588	419	22	addition	addition	NOUN
cusj-5588	419	23	to	to	ADP
cusj-5588	419	24	heavy	heavy	ADJ
cusj-5588	419	25	ethical	ethical	ADJ
cusj-5588	419	26	concerns	concern	NOUN
cusj-5588	419	27	raised	raise	VERB
cusj-5588	419	28	over	over	ADP
cusj-5588	419	29	the	the	DET
cusj-5588	419	30	use	use	NOUN
cusj-5588	419	31	of	of	ADP
cusj-5588	419	32	fetal	fetal	ADJ
cusj-5588	419	33	tissue	tissue	NOUN
cusj-5588	419	34	as	as	ADP
cusj-5588	419	35	a	a	DET
cusj-5588	419	36	therapeutic	therapeutic	ADJ
cusj-5588	419	37	source	source	NOUN
cusj-5588	419	38	,	,	PUNCT
cusj-5588	419	39	has	have	AUX
cusj-5588	419	40	heavily	heavily	ADV
cusj-5588	419	41	impeded	impede	VERB
cusj-5588	419	42	the	the	DET
cusj-5588	419	43	clinical	clinical	ADJ
cusj-5588	419	44	development	development	NOUN
cusj-5588	419	45	of	of	ADP
cusj-5588	419	46	this	this	DET
cusj-5588	419	47	form	form	NOUN
cusj-5588	419	48	of	of	ADP
cusj-5588	419	49	hfvm	hfvm	NOUN
cusj-5588	419	50	-	-	PUNCT
cusj-5588	419	51	based	base	VERB
cusj-5588	419	52	therapy	therapy	NOUN
cusj-5588	419	53	(	(	PUNCT
cusj-5588	419	54	brundin	brundin	VERB
cusj-5588	419	55	et	et	PROPN
cusj-5588	419	56	al	al	PROPN
cusj-5588	419	57	.	.	PROPN
cusj-5588	419	58	,	,	PUNCT
cusj-5588	419	59	2010	2010	NUM
cusj-5588	419	60	)	)	PUNCT
cusj-5588	419	61	.	.	PUNCT
cusj-5588	420	1	instead	instead	ADV
cusj-5588	420	2	,	,	PUNCT
cusj-5588	420	3	the	the	DET
cusj-5588	420	4	focus	focus	NOUN
cusj-5588	420	5	has	have	AUX
cusj-5588	420	6	been	be	AUX
cusj-5588	420	7	shifted	shift	VERB
cusj-5588	420	8	to	to	ADP
cusj-5588	420	9	escs	esc	NOUN
cusj-5588	420	10	and	and	CCONJ
cusj-5588	420	11	ipscs	ipsc	NOUN
cusj-5588	420	12	:	:	PUNCT
cusj-5588	420	13	mouse	mouse	PROPN
cusj-5588	420	14	model	model	NOUN
cusj-5588	420	15	studies	study	NOUN
cusj-5588	420	16	have	have	AUX
cusj-5588	420	17	found	find	VERB
cusj-5588	420	18	that	that	SCONJ
cusj-5588	420	19	overexpression	overexpression	NOUN
cusj-5588	420	20	of	of	ADP
cusj-5588	420	21	nurr1	nurr1	NOUN
cusj-5588	420	22	,	,	PUNCT
cusj-5588	420	23	fgf-8	fgf-8	ADV
cusj-5588	420	24	,	,	PUNCT
cusj-5588	420	25	and	and	CCONJ
cusj-5588	420	26	shh	shh	INTJ
cusj-5588	420	27	signalling	signal	VERB
cusj-5588	420	28	in	in	ADP
cusj-5588	420	29	mouse	mouse	NOUN
cusj-5588	420	30	escs	esc	NOUN
cusj-5588	420	31	and	and	CCONJ
cusj-5588	420	32	ipscs	ipscs	NOUN
cusj-5588	420	33	has	have	AUX
cusj-5588	420	34	successfully	successfully	ADV
cusj-5588	420	35	induced	induce	VERB
cusj-5588	420	36	midbrain	midbrain	NOUN
cusj-5588	420	37	dopaminergic	dopaminergic	ADJ
cusj-5588	420	38	phenotypes	phenotype	NOUN
cusj-5588	420	39	and	and	CCONJ
cusj-5588	420	40	improved	improve	VERB
cusj-5588	420	41	functional	functional	ADJ
cusj-5588	420	42	recovery	recovery	NOUN
cusj-5588	420	43	(	(	PUNCT
cusj-5588	420	44	kim	kim	PROPN
cusj-5588	420	45	et	et	PROPN
cusj-5588	420	46	al	al	PROPN
cusj-5588	420	47	.	.	PROPN
cusj-5588	420	48	,	,	PUNCT
cusj-5588	420	49	2003	2003	NUM
cusj-5588	420	50	;	;	PUNCT
cusj-5588	420	51	cooper	cooper	PROPN
cusj-5588	420	52	et	et	PROPN
cusj-5588	420	53	al	al	PROPN
cusj-5588	420	54	.	.	PROPN
cusj-5588	420	55	,	,	PUNCT
cusj-5588	420	56	2010	2010	NUM
cusj-5588	420	57	)	)	PUNCT
cusj-5588	420	58	.	.	PUNCT
cusj-5588	421	1	a	a	DET
cusj-5588	421	2	major	major	ADJ
cusj-5588	421	3	concern	concern	NOUN
cusj-5588	421	4	for	for	ADP
cusj-5588	421	5	esc	esc	NOUN
cusj-5588	421	6	clinical	clinical	ADJ
cusj-5588	421	7	transplants	transplant	NOUN
cusj-5588	421	8	,	,	PUNCT
cusj-5588	421	9	however	however	ADV
cusj-5588	421	10	,	,	PUNCT
cusj-5588	421	11	is	be	AUX
cusj-5588	421	12	the	the	DET
cusj-5588	421	13	risk	risk	NOUN
cusj-5588	421	14	for	for	ADP
cusj-5588	421	15	tumour	tumour	NOUN
cusj-5588	421	16	formation	formation	NOUN
cusj-5588	421	17	observed	observe	VERB
cusj-5588	421	18	in	in	ADP
cusj-5588	421	19	animal	animal	NOUN
cusj-5588	421	20	models	model	NOUN
cusj-5588	421	21	(	(	PUNCT
cusj-5588	421	22	lindvall	lindvall	PROPN
cusj-5588	421	23	&	&	CCONJ
cusj-5588	421	24	kokaia	kokaia	PROPN
cusj-5588	421	25	,	,	PUNCT
cusj-5588	421	26	2010	2010	NUM
cusj-5588	421	27	)	)	PUNCT
cusj-5588	421	28	.	.	PUNCT
cusj-5588	422	1	as	as	SCONJ
cusj-5588	422	2	pd	pd	PROPN
cusj-5588	422	3	patients	patient	NOUN
cusj-5588	422	4	have	have	VERB
cusj-5588	422	5	normal	normal	ADJ
cusj-5588	422	6	life	life	NOUN
cusj-5588	422	7	expectancies	expectancy	NOUN
cusj-5588	422	8	,	,	PUNCT
cusj-5588	422	9	even	even	ADV
cusj-5588	422	10	a	a	DET
cusj-5588	422	11	slim	slim	ADJ
cusj-5588	422	12	risk	risk	NOUN
cusj-5588	422	13	of	of	ADP
cusj-5588	422	14	tumour	tumour	NOUN
cusj-5588	422	15	formation	formation	NOUN
cusj-5588	422	16	is	be	AUX
cusj-5588	422	17	unacceptable	unacceptable	ADJ
cusj-5588	422	18	.	.	PUNCT
cusj-5588	423	1	initial	initial	ADJ
cusj-5588	423	2	suggestions	suggestion	NOUN
cusj-5588	423	3	of	of	ADP
cusj-5588	423	4	hfvm	hfvm	NOUN
cusj-5588	423	5	transplant	transplant	NOUN
cusj-5588	423	6	-	-	PUNCT
cusj-5588	423	7	mediated	mediate	VERB
cusj-5588	423	8	pd	pd	NOUN
cusj-5588	423	9	therapy	therapy	NOUN
cusj-5588	423	10	have	have	AUX
cusj-5588	423	11	been	be	AUX
cusj-5588	423	12	significantly	significantly	ADV
cusj-5588	423	13	hindered	hinder	VERB
cusj-5588	423	14	by	by	ADP
cusj-5588	423	15	ethical	ethical	ADJ
cusj-5588	423	16	and	and	CCONJ
cusj-5588	423	17	methodological	methodological	ADJ
cusj-5588	423	18	issues	issue	NOUN
cusj-5588	423	19	,	,	PUNCT
cusj-5588	423	20	while	while	SCONJ
cusj-5588	423	21	the	the	DET
cusj-5588	423	22	induction	induction	NOUN
cusj-5588	423	23	of	of	ADP
cusj-5588	423	24	escs	esc	NOUN
cusj-5588	423	25	and	and	CCONJ
cusj-5588	423	26	ipscs	ipscs	NOUN
cusj-5588	423	27	into	into	ADP
cusj-5588	423	28	dopaminergic	dopaminergic	ADJ
cusj-5588	423	29	neurons	neuron	NOUN
cusj-5588	423	30	is	be	AUX
cusj-5588	423	31	cumbersome	cumbersome	ADJ
cusj-5588	423	32	,	,	PUNCT
cusj-5588	423	33	potentially	potentially	ADV
cusj-5588	423	34	nonhomogeneous	nonhomogeneous	ADJ
cusj-5588	423	35	(	(	PUNCT
cusj-5588	423	36	may	may	AUX
cusj-5588	423	37	contain	contain	VERB
cusj-5588	423	38	traces	trace	NOUN
cusj-5588	423	39	of	of	ADP
cusj-5588	423	40	undifferentiated	undifferentiated	ADJ
cusj-5588	423	41	cells	cell	NOUN
cusj-5588	423	42	that	that	PRON
cusj-5588	423	43	can	can	AUX
cusj-5588	423	44	lead	lead	VERB
cusj-5588	423	45	to	to	ADP
cusj-5588	423	46	teratomas	teratoma	NOUN
cusj-5588	423	47	)	)	PUNCT
cusj-5588	423	48	,	,	PUNCT
cusj-5588	423	49	and	and	CCONJ
cusj-5588	423	50	currently	currently	ADV
cusj-5588	423	51	unsubstantiated	unsubstantiate	VERB
cusj-5588	423	52	by	by	ADP
cusj-5588	423	53	clinical	clinical	ADJ
cusj-5588	423	54	studies	study	NOUN
cusj-5588	423	55	.	.	PUNCT
cusj-5588	424	1	thus	thus	ADV
cusj-5588	424	2	,	,	PUNCT
cusj-5588	424	3	progress	progress	NOUN
cusj-5588	424	4	made	make	VERB
cusj-5588	424	5	in	in	ADP
cusj-5588	424	6	stem	stem	NOUN
cusj-5588	424	7	cell	cell	NOUN
cusj-5588	424	8	-	-	PUNCT
cusj-5588	424	9	based	base	VERB
cusj-5588	424	10	pd	pd	PROPN
cusj-5588	424	11	treatments	treatment	NOUN
cusj-5588	424	12	have	have	AUX
cusj-5588	424	13	been	be	AUX
cusj-5588	424	14	slower	slow	ADJ
cusj-5588	424	15	than	than	ADP
cusj-5588	424	16	for	for	ADP
cusj-5588	424	17	ad	ad	NOUN
cusj-5588	424	18	.	.	PUNCT
cusj-5588	425	1	however	however	ADV
cusj-5588	425	2	,	,	PUNCT
cusj-5588	425	3	ipsc	ipsc	NOUN
cusj-5588	425	4	-	-	PUNCT
cusj-5588	425	5	derived	derive	VERB
cusj-5588	425	6	dopaminergic	dopaminergic	ADJ
cusj-5588	425	7	neurons	neuron	NOUN
cusj-5588	425	8	have	have	AUX
cusj-5588	425	9	provided	provide	VERB
cusj-5588	425	10	critical	critical	ADJ
cusj-5588	425	11	insights	insight	NOUN
cusj-5588	425	12	into	into	ADP
cusj-5588	425	13	the	the	DET
cusj-5588	425	14	pathophysiology	pathophysiology	NOUN
cusj-5588	425	15	of	of	ADP
cusj-5588	425	16	pd	pd	PROPN
cusj-5588	425	17	,	,	PUNCT
cusj-5588	425	18	by	by	ADP
cusj-5588	425	19	providing	provide	VERB
cusj-5588	425	20	a	a	DET
cusj-5588	425	21	sc	sc	NOUN
cusj-5588	425	22	-	-	PUNCT
cusj-5588	425	23	based	base	VERB
cusj-5588	425	24	human	human	ADJ
cusj-5588	425	25	disease	disease	NOUN
cusj-5588	425	26	model	model	NOUN
cusj-5588	425	27	.	.	PUNCT
cusj-5588	426	1	abnormalities	abnormality	NOUN
cusj-5588	426	2	in	in	ADP
cusj-5588	426	3	mitochondrial	mitochondrial	ADJ
cusj-5588	426	4	and	and	CCONJ
cusj-5588	426	5	dopamine	dopamine	NOUN
cusj-5588	426	6	homeostasis	homeostasis	NOUN
cusj-5588	426	7	,	,	PUNCT
cusj-5588	426	8	as	as	ADV
cusj-5588	426	9	well	well	ADV
cusj-5588	426	10	as	as	ADP
cusj-5588	426	11	mutations	mutation	NOUN
cusj-5588	426	12	in	in	ADP
cusj-5588	426	13	parkin	parkin	ADJ
cusj-5588	426	14	and	and	CCONJ
cusj-5588	426	15	pten	pten	ADV
cusj-5588	426	16	-	-	PUNCT
cusj-5588	426	17	induced	induce	VERB
cusj-5588	426	18	putative	putative	ADJ
cusj-5588	426	19	kinase	kinase	NOUN
cusj-5588	426	20	1	1	NUM
cusj-5588	426	21	(	(	PUNCT
cusj-5588	426	22	pink1	pink1	NOUN
cusj-5588	426	23	)	)	PUNCT
cusj-5588	426	24	previously	previously	ADV
cusj-5588	426	25	noted	note	VERB
cusj-5588	426	26	in	in	ADP
cusj-5588	426	27	animal	animal	NOUN
cusj-5588	426	28	models	model	NOUN
cusj-5588	426	29	have	have	AUX
cusj-5588	426	30	been	be	AUX
cusj-5588	426	31	substantiated	substantiate	VERB
cusj-5588	426	32	by	by	ADP
cusj-5588	426	33	similar	similar	ADJ
cusj-5588	426	34	data	datum	NOUN
cusj-5588	426	35	from	from	ADP
cusj-5588	426	36	studies	study	NOUN
cusj-5588	426	37	using	use	VERB
cusj-5588	426	38	pd	pd	NOUN
cusj-5588	426	39	patient	patient	NOUN
cusj-5588	426	40	-	-	PUNCT
cusj-5588	426	41	derived	derive	VERB
cusj-5588	426	42	ipsc	ipsc	NOUN
cusj-5588	426	43	neurons	neuron	NOUN
cusj-5588	426	44	(	(	PUNCT
cusj-5588	426	45	van	van	PROPN
cusj-5588	426	46	laar	laar	PROPN
cusj-5588	426	47	et	et	PROPN
cusj-5588	426	48	al	al	PROPN
cusj-5588	426	49	.	.	PROPN
cusj-5588	426	50	,	,	PUNCT
cusj-5588	426	51	2010	2010	NUM
cusj-5588	426	52	;	;	PUNCT
cusj-5588	426	53	cai	cai	PROPN
cusj-5588	426	54	et	et	PROPN
cusj-5588	426	55	al	al	PROPN
cusj-5588	426	56	.	.	PROPN
cusj-5588	426	57	,	,	PUNCT
cusj-5588	426	58	2012	2012	NUM
cusj-5588	426	59	)	)	PUNCT
cusj-5588	426	60	.	.	PUNCT
cusj-5588	427	1	though	though	SCONJ
cusj-5588	427	2	stem	stem	NOUN
cusj-5588	427	3	cell	cell	NOUN
cusj-5588	427	4	technology	technology	NOUN
cusj-5588	427	5	has	have	VERB
cusj-5588	427	6	yet	yet	ADV
cusj-5588	427	7	to	to	PART
cusj-5588	427	8	develop	develop	VERB
cusj-5588	427	9	clinically	clinically	ADV
cusj-5588	427	10	-	-	PUNCT
cusj-5588	427	11	relevant	relevant	ADJ
cusj-5588	427	12	pd	pd	PROPN
cusj-5588	427	13	therapies	therapy	NOUN
cusj-5588	427	14	,	,	PUNCT
cusj-5588	427	15	it	it	PRON
cusj-5588	427	16	has	have	AUX
cusj-5588	427	17	proved	prove	VERB
cusj-5588	427	18	effective	effective	ADJ
cusj-5588	427	19	in	in	ADP
cusj-5588	427	20	modelling	model	VERB
cusj-5588	427	21	parkinson	parkinson	NOUN
cusj-5588	427	22	’s	’s	NOUN
cusj-5588	427	23	.	.	PUNCT
cusj-5588	428	1	in	in	ADP
cusj-5588	428	2	particular	particular	ADJ
cusj-5588	428	3	,	,	PUNCT
cusj-5588	428	4	mutation	mutation	NOUN
cusj-5588	428	5	-	-	PUNCT
cusj-5588	428	6	bearing	bear	VERB
cusj-5588	428	7	ipscs	ipscs	NOUN
cusj-5588	428	8	has	have	AUX
cusj-5588	428	9	helped	help	VERB
cusj-5588	428	10	study	study	VERB
cusj-5588	428	11	pd	pd	PROPN
cusj-5588	428	12	physiology	physiology	NOUN
cusj-5588	428	13	,	,	PUNCT
cusj-5588	428	14	elucidate	elucidate	VERB
cusj-5588	428	15	underlying	underlying	ADJ
cusj-5588	428	16	signalling	signal	VERB
cusj-5588	428	17	cascades	cascade	NOUN
cusj-5588	428	18	modulating	modulate	VERB
cusj-5588	428	19	the	the	DET
cusj-5588	428	20	disease	disease	NOUN
cusj-5588	428	21	,	,	PUNCT
cusj-5588	428	22	identify	identify	VERB
cusj-5588	428	23	pd	pd	ADJ
cusj-5588	428	24	biochemical	biochemical	ADJ
cusj-5588	428	25	markers	marker	NOUN
cusj-5588	428	26	,	,	PUNCT
cusj-5588	428	27	and	and	CCONJ
cusj-5588	428	28	screen	screen	NOUN
cusj-5588	428	29	efficiency	efficiency	NOUN
cusj-5588	428	30	of	of	ADP
cusj-5588	428	31	therapeutic	therapeutic	ADJ
cusj-5588	428	32	compounds	compound	NOUN
cusj-5588	428	33	.	.	PUNCT
cusj-5588	429	1	huntington	huntington	PROPN
cusj-5588	429	2	’s	’s	PART
cusj-5588	429	3	applications	application	NOUN
cusj-5588	429	4	of	of	ADP
cusj-5588	429	5	stem	stem	NOUN
cusj-5588	429	6	cell	cell	NOUN
cusj-5588	429	7	techniques	technique	NOUN
cusj-5588	429	8	in	in	ADP
cusj-5588	429	9	hd	hd	NOUN
cusj-5588	429	10	studies	study	NOUN
cusj-5588	429	11	have	have	AUX
cusj-5588	429	12	paralleled	parallel	VERB
cusj-5588	429	13	those	those	PRON
cusj-5588	429	14	for	for	ADP
cusj-5588	429	15	ad	ad	NOUN
cusj-5588	429	16	and	and	CCONJ
cusj-5588	429	17	pd	pd	NOUN
cusj-5588	429	18	.	.	PROPN
cusj-5588	429	19	more	more	ADV
cusj-5588	429	20	specifically	specifically	ADV
cusj-5588	429	21	,	,	PUNCT
cusj-5588	429	22	fetal	fetal	ADJ
cusj-5588	429	23	striatal	striatal	NOUN
cusj-5588	429	24	grafting	grafting	NOUN
cusj-5588	429	25	into	into	ADP
cusj-5588	429	26	hd	hd	NOUN
cusj-5588	429	27	patients	patient	NOUN
cusj-5588	429	28	have	have	AUX
cusj-5588	429	29	provided	provide	VERB
cusj-5588	429	30	transient	transient	ADJ
cusj-5588	429	31	symptom	symptom	NOUN
cusj-5588	429	32	improvements	improvement	NOUN
cusj-5588	429	33	,	,	PUNCT
cusj-5588	429	34	but	but	CCONJ
cusj-5588	429	35	its	its	PRON
cusj-5588	429	36	mechanisms	mechanism	NOUN
cusj-5588	429	37	are	be	AUX
cusj-5588	429	38	poorly	poorly	ADV
cusj-5588	429	39	understood	understand	VERB
cusj-5588	429	40	and	and	CCONJ
cusj-5588	429	41	its	its	PRON
cusj-5588	429	42	use	use	NOUN
cusj-5588	429	43	is	be	AUX
cusj-5588	429	44	limited	limit	VERB
cusj-5588	429	45	by	by	ADP
cusj-5588	429	46	ethical	ethical	ADJ
cusj-5588	429	47	constraints	constraint	NOUN
cusj-5588	429	48	(	(	PUNCT
cusj-5588	429	49	bachoud	bachoud	NOUN
cusj-5588	429	50	-	-	PUNCT
cusj-5588	429	51	lévi	lévi	NOUN
cusj-5588	429	52	et	et	PROPN
cusj-5588	429	53	al	al	PROPN
cusj-5588	429	54	.	.	PROPN
cusj-5588	429	55	,	,	PUNCT
cusj-5588	429	56	2000	2000	NUM
cusj-5588	429	57	)	)	PUNCT
cusj-5588	429	58	.	.	PUNCT
cusj-5588	430	1	both	both	DET
cusj-5588	430	2	ipscs	ipsc	NOUN
cusj-5588	430	3	and	and	CCONJ
cusj-5588	430	4	escs	esc	NOUN
cusj-5588	430	5	have	have	AUX
cusj-5588	430	6	been	be	AUX
cusj-5588	430	7	13	13	NUM
cusj-5588	430	8	cusj	cusj	NOUN
cusj-5588	430	9	2018	2018	NUM
cusj-5588	430	10	_	_	PUNCT
cusj-5588	431	1	_	_	PUNCT
cusj-5588	432	1	_	_	PUNCT
cusj-5588	433	1	_	_	PUNCT
cusj-5588	434	1	_	_	PUNCT
cusj-5588	435	1	_	_	PUNCT
cusj-5588	436	1	_	_	PUNCT
cusj-5588	437	1	_	_	PUNCT
cusj-5588	438	1	_	_	PUNCT
cusj-5588	439	1	_	_	PUNCT
cusj-5588	440	1	_	_	PUNCT
cusj-5588	441	1	_	_	PUNCT
cusj-5588	442	1	_	_	PUNCT
cusj-5588	443	1	_	_	PUNCT
cusj-5588	444	1	_	_	PUNCT
cusj-5588	445	1	_	_	PUNCT
cusj-5588	446	1	_	_	PUNCT
cusj-5588	447	1	_	_	PUNCT
cusj-5588	448	1	_	_	PUNCT
cusj-5588	449	1	_	_	PUNCT
cusj-5588	450	1	_	_	PUNCT
cusj-5588	451	1	_	_	PUNCT
cusj-5588	452	1	_	_	PUNCT
cusj-5588	453	1	_	_	PUNCT
cusj-5588	454	1	_	_	PUNCT
cusj-5588	455	1	_	_	PUNCT
cusj-5588	456	1	_	_	PUNCT
cusj-5588	457	1	_	_	PUNCT
cusj-5588	458	1	_	_	PUNCT
cusj-5588	459	1	_	_	PUNCT
cusj-5588	460	1	_	_	PUNCT
cusj-5588	461	1	_	_	PUNCT
cusj-5588	462	1	_	_	PUNCT
cusj-5588	463	1	_	_	PUNCT
cusj-5588	464	1	_	_	PUNCT
cusj-5588	465	1	_	_	PUNCT
cusj-5588	466	1	_	_	PUNCT
cusj-5588	467	1	_	_	PUNCT
cusj-5588	468	1	_	_	PUNCT
cusj-5588	469	1	_	_	PUNCT
cusj-5588	470	1	_	_	PUNCT
cusj-5588	471	1	_	_	PUNCT
cusj-5588	472	1	_	_	PUNCT
cusj-5588	473	1	_	_	PUNCT
cusj-5588	474	1	_	_	PUNCT
cusj-5588	475	1	_	_	PUNCT
cusj-5588	476	1	_	_	PUNCT
cusj-5588	477	1	_	_	PUNCT
cusj-5588	478	1	_	_	PUNCT
cusj-5588	479	1	_	_	PUNCT
cusj-5588	480	1	_	_	PUNCT
cusj-5588	481	1	_	_	PUNCT
cusj-5588	482	1	_	_	PUNCT
cusj-5588	483	1	_	_	PUNCT
cusj-5588	484	1	_	_	PUNCT
cusj-5588	485	1	_	_	PUNCT
cusj-5588	486	1	_	_	PUNCT
cusj-5588	487	1	_	_	PUNCT
cusj-5588	488	1	_	_	PUNCT
cusj-5588	489	1	_	_	PUNCT
cusj-5588	490	1	_	_	PUNCT
cusj-5588	491	1	_	_	PUNCT
cusj-5588	492	1	_	_	PUNCT
cusj-5588	493	1	_	_	PUNCT
cusj-5588	494	1	_	_	PUNCT
cusj-5588	495	1	_	_	PUNCT
cusj-5588	496	1	_	_	PUNCT
cusj-5588	497	1	_	_	PUNCT
cusj-5588	498	1	_	_	PUNCT
cusj-5588	499	1	_	_	PUNCT
cusj-5588	500	1	_	_	PUNCT
cusj-5588	501	1	_	_	PUNCT
cusj-5588	502	1	_	_	PUNCT
cusj-5588	503	1	_	_	PUNCT
cusj-5588	504	1	_	_	PUNCT
cusj-5588	505	1	_	_	PUNCT
cusj-5588	506	1	_	_	PUNCT
cusj-5588	507	1	_	_	PUNCT
cusj-5588	508	1	_	_	PUNCT
cusj-5588	509	1	_	_	PUNCT
cusj-5588	509	2	used	use	VERB
cusj-5588	509	3	to	to	PART
cusj-5588	509	4	establish	establish	VERB
cusj-5588	509	5	differentiation	differentiation	NOUN
cusj-5588	509	6	protocols	protocol	NOUN
cusj-5588	509	7	for	for	ADP
cusj-5588	509	8	medium	medium	ADJ
cusj-5588	509	9	spiny	spiny	ADJ
cusj-5588	509	10	neurons	neuron	NOUN
cusj-5588	509	11	(	(	PUNCT
cusj-5588	509	12	msn	msn	NOUN
cusj-5588	509	13	)	)	PUNCT
cusj-5588	509	14	—	—	PUNCT
cusj-5588	509	15	these	these	DET
cusj-5588	509	16	transplantations	transplantation	NOUN
cusj-5588	509	17	have	have	AUX
cusj-5588	509	18	shown	show	VERB
cusj-5588	509	19	successful	successful	ADJ
cusj-5588	509	20	neural	neural	ADJ
cusj-5588	509	21	circuit	circuit	NOUN
cusj-5588	509	22	development	development	NOUN
cusj-5588	509	23	and	and	CCONJ
cusj-5588	509	24	integration	integration	NOUN
cusj-5588	509	25	,	,	PUNCT
cusj-5588	509	26	but	but	CCONJ
cusj-5588	509	27	are	be	AUX
cusj-5588	509	28	currently	currently	ADV
cusj-5588	509	29	restricted	restrict	VERB
cusj-5588	509	30	to	to	ADP
cusj-5588	509	31	animal	animal	NOUN
cusj-5588	509	32	models	model	NOUN
cusj-5588	509	33	(	(	PUNCT
cusj-5588	509	34	viegas	viegas	X
cusj-5588	509	35	et	et	PROPN
cusj-5588	509	36	al	al	PROPN
cusj-5588	509	37	.	.	PROPN
cusj-5588	509	38	,	,	PUNCT
cusj-5588	509	39	2011	2011	NUM
cusj-5588	509	40	;	;	PUNCT
cusj-5588	509	41	precious	precious	ADJ
cusj-5588	509	42	&	&	CCONJ
cusj-5588	509	43	rosser	rosser	PROPN
cusj-5588	509	44	,	,	PUNCT
cusj-5588	509	45	2012	2012	NUM
cusj-5588	509	46	)	)	PUNCT
cusj-5588	509	47	.	.	PUNCT
cusj-5588	510	1	initial	initial	ADJ
cusj-5588	510	2	clinical	clinical	ADJ
cusj-5588	510	3	trials	trial	NOUN
cusj-5588	510	4	using	use	VERB
cusj-5588	510	5	fetal	fetal	NOUN
cusj-5588	510	6	-	-	PUNCT
cusj-5588	510	7	derived	derive	VERB
cusj-5588	510	8	tissue	tissue	NOUN
cusj-5588	510	9	,	,	PUNCT
cusj-5588	510	10	ipscs	ipsc	NOUN
cusj-5588	510	11	,	,	PUNCT
cusj-5588	510	12	or	or	CCONJ
cusj-5588	510	13	escs	esc	NOUN
cusj-5588	510	14	as	as	SCONJ
cusj-5588	510	15	sources	source	NOUN
cusj-5588	510	16	of	of	ADP
cusj-5588	510	17	msns	msns	PROPN
cusj-5588	510	18	have	have	AUX
cusj-5588	510	19	observed	observe	VERB
cusj-5588	510	20	reduced	reduce	VERB
cusj-5588	510	21	motor	motor	NOUN
cusj-5588	510	22	and	and	CCONJ
cusj-5588	510	23	cognitive	cognitive	ADJ
cusj-5588	510	24	dysfunction	dysfunction	NOUN
cusj-5588	510	25	in	in	ADP
cusj-5588	510	26	hd	hd	NOUN
cusj-5588	510	27	patients	patient	NOUN
cusj-5588	510	28	.	.	PUNCT
cusj-5588	511	1	in	in	ADP
cusj-5588	511	2	addition	addition	NOUN
cusj-5588	511	3	,	,	PUNCT
cusj-5588	511	4	decreased	decrease	VERB
cusj-5588	511	5	neuronal	neuronal	ADJ
cusj-5588	511	6	loss	loss	NOUN
cusj-5588	511	7	was	be	AUX
cusj-5588	511	8	observed	observe	VERB
cusj-5588	511	9	in	in	ADP
cusj-5588	511	10	hd	hd	NOUN
cusj-5588	511	11	rodents	rodent	NOUN
cusj-5588	511	12	with	with	ADP
cusj-5588	511	13	npc	npc	NOUN
cusj-5588	511	14	transplants	transplant	NOUN
cusj-5588	511	15	engineered	engineer	VERB
cusj-5588	511	16	to	to	ADP
cusj-5588	511	17	overexpress	overexpress	NOUN
cusj-5588	511	18	gdnf	gdnf	PROPN
cusj-5588	511	19	,	,	PUNCT
cusj-5588	511	20	as	as	SCONJ
cusj-5588	511	21	compared	compare	VERB
cusj-5588	511	22	to	to	PART
cusj-5588	511	23	control	control	VERB
cusj-5588	511	24	mice	mouse	NOUN
cusj-5588	511	25	with	with	ADP
cusj-5588	511	26	unmodified	unmodified	ADJ
cusj-5588	511	27	nsc	nsc	PROPN
cusj-5588	511	28	transplants	transplant	NOUN
cusj-5588	511	29	,	,	PUNCT
cusj-5588	511	30	emphasizing	emphasize	VERB
cusj-5588	511	31	the	the	DET
cusj-5588	511	32	potential	potential	NOUN
cusj-5588	511	33	of	of	ADP
cusj-5588	511	34	stem	stem	NOUN
cusj-5588	511	35	cell	cell	NOUN
cusj-5588	511	36	-	-	PUNCT
cusj-5588	511	37	based	base	VERB
cusj-5588	511	38	therapies	therapy	NOUN
cusj-5588	511	39	to	to	PART
cusj-5588	511	40	provide	provide	VERB
cusj-5588	511	41	environmental	environmental	ADJ
cusj-5588	511	42	enrichment	enrichment	NOUN
cusj-5588	511	43	and	and	CCONJ
cusj-5588	511	44	protect	protect	VERB
cusj-5588	511	45	endogenous	endogenous	ADJ
cusj-5588	511	46	neurons	neuron	NOUN
cusj-5588	511	47	(	(	PUNCT
cusj-5588	511	48	pineda	pineda	PROPN
cusj-5588	511	49	,	,	PUNCT
cusj-5588	511	50	2007	2007	NUM
cusj-5588	511	51	)	)	PUNCT
cusj-5588	511	52	.	.	PUNCT
cusj-5588	512	1	for	for	ADP
cusj-5588	512	2	ad	ad	NOUN
cusj-5588	512	3	,	,	PUNCT
cusj-5588	512	4	pd	pd	NOUN
cusj-5588	512	5	,	,	PUNCT
cusj-5588	512	6	and	and	CCONJ
cusj-5588	512	7	hd	hd	PROPN
cusj-5588	512	8	,	,	PUNCT
cusj-5588	512	9	similar	similar	ADJ
cusj-5588	512	10	trends	trend	NOUN
cusj-5588	512	11	in	in	ADP
cusj-5588	512	12	stem	stem	NOUN
cusj-5588	512	13	cell	cell	NOUN
cusj-5588	512	14	-	-	PUNCT
cusj-5588	512	15	based	base	VERB
cusj-5588	512	16	therapies	therapy	NOUN
cusj-5588	512	17	can	can	AUX
cusj-5588	512	18	be	be	AUX
cusj-5588	512	19	observed	observe	VERB
cusj-5588	512	20	.	.	PUNCT
cusj-5588	513	1	early	early	ADJ
cusj-5588	513	2	cell	cell	NOUN
cusj-5588	513	3	-	-	PUNCT
cusj-5588	513	4	based	base	VERB
cusj-5588	513	5	therapies	therapy	NOUN
cusj-5588	513	6	using	use	VERB
cusj-5588	513	7	fetal	fetal	ADJ
cusj-5588	513	8	ventral	ventral	ADJ
cusj-5588	513	9	mesencephalic	mesencephalic	ADJ
cusj-5588	513	10	tissue	tissue	NOUN
cusj-5588	513	11	(	(	PUNCT
cusj-5588	513	12	for	for	ADP
cusj-5588	513	13	pd	pd	NOUN
cusj-5588	513	14	)	)	PUNCT
cusj-5588	513	15	and	and	CCONJ
cusj-5588	513	16	fetal	fetal	ADJ
cusj-5588	513	17	striatal	striatal	ADJ
cusj-5588	513	18	tissue	tissue	NOUN
cusj-5588	513	19	(	(	PUNCT
cusj-5588	513	20	for	for	ADP
cusj-5588	513	21	hd	hd	NOUN
cusj-5588	513	22	)	)	PUNCT
cusj-5588	513	23	transplants	transplant	NOUN
cusj-5588	513	24	provided	provide	VERB
cusj-5588	513	25	initial	initial	ADJ
cusj-5588	513	26	support	support	NOUN
cusj-5588	513	27	for	for	ADP
cusj-5588	513	28	successful	successful	ADJ
cusj-5588	513	29	symptomatic	symptomatic	ADJ
cusj-5588	513	30	relief	relief	NOUN
cusj-5588	513	31	.	.	PUNCT
cusj-5588	514	1	however	however	ADV
cusj-5588	514	2	,	,	PUNCT
cusj-5588	514	3	widespread	widespread	ADJ
cusj-5588	514	4	clinical	clinical	ADJ
cusj-5588	514	5	applications	application	NOUN
cusj-5588	514	6	of	of	ADP
cusj-5588	514	7	human	human	ADJ
cusj-5588	514	8	fetal	fetal	ADJ
cusj-5588	514	9	tissue	tissue	NOUN
cusj-5588	514	10	transplants	transplant	NOUN
cusj-5588	514	11	has	have	AUX
cusj-5588	514	12	been	be	AUX
cusj-5588	514	13	limited	limit	VERB
cusj-5588	514	14	by	by	ADP
cusj-5588	514	15	significant	significant	ADJ
cusj-5588	514	16	ethical	ethical	ADJ
cusj-5588	514	17	and	and	CCONJ
cusj-5588	514	18	scarcity	scarcity	NOUN
cusj-5588	514	19	issues	issue	NOUN
cusj-5588	514	20	associated	associate	VERB
cusj-5588	514	21	with	with	ADP
cusj-5588	514	22	the	the	DET
cusj-5588	514	23	nature	nature	NOUN
cusj-5588	514	24	of	of	ADP
cusj-5588	514	25	the	the	DET
cusj-5588	514	26	tissue	tissue	NOUN
cusj-5588	514	27	source	source	NOUN
cusj-5588	514	28	.	.	PUNCT
cusj-5588	515	1	subsequent	subsequent	ADJ
cusj-5588	515	2	clinical	clinical	ADJ
cusj-5588	515	3	trials	trial	NOUN
cusj-5588	515	4	have	have	AUX
cusj-5588	515	5	failed	fail	VERB
cusj-5588	515	6	to	to	PART
cusj-5588	515	7	consistently	consistently	ADV
cusj-5588	515	8	replicate	replicate	VERB
cusj-5588	515	9	initial	initial	ADJ
cusj-5588	515	10	data	datum	NOUN
cusj-5588	515	11	and	and	CCONJ
cusj-5588	515	12	observed	observe	VERB
cusj-5588	515	13	deleterious	deleterious	ADJ
cusj-5588	515	14	side	side	NOUN
cusj-5588	515	15	effects	effect	NOUN
cusj-5588	515	16	(	(	PUNCT
cusj-5588	515	17	teratoma	teratoma	NOUN
cusj-5588	515	18	formation	formation	NOUN
cusj-5588	515	19	,	,	PUNCT
cusj-5588	515	20	gids	gid	NOUN
cusj-5588	515	21	,	,	PUNCT
cusj-5588	515	22	immunorejection	immunorejection	NOUN
cusj-5588	515	23	)	)	PUNCT
cusj-5588	515	24	.	.	PUNCT
cusj-5588	516	1	thus	thus	ADV
cusj-5588	516	2	,	,	PUNCT
cusj-5588	516	3	the	the	DET
cusj-5588	516	4	focus	focus	NOUN
cusj-5588	516	5	of	of	ADP
cusj-5588	516	6	stem	stem	NOUN
cusj-5588	516	7	cell	cell	NOUN
cusj-5588	516	8	therapies	therapy	NOUN
cusj-5588	516	9	has	have	AUX
cusj-5588	516	10	shifted	shift	VERB
cusj-5588	516	11	to	to	ADP
cusj-5588	516	12	escs	esc	NOUN
cusj-5588	516	13	derived	derive	VERB
cusj-5588	516	14	nscs	nsc	NOUN
cusj-5588	516	15	induced	induce	VERB
cusj-5588	516	16	to	to	ADP
cusj-5588	516	17	certain	certain	ADJ
cusj-5588	516	18	cell	cell	NOUN
cusj-5588	516	19	fates	fate	NOUN
cusj-5588	516	20	or	or	CCONJ
cusj-5588	516	21	gene	gene	NOUN
cusj-5588	516	22	expressions	expression	NOUN
cusj-5588	516	23	(	(	PUNCT
cusj-5588	516	24	increased	increase	VERB
cusj-5588	516	25	bdnf	bdnf	ADJ
cusj-5588	516	26	/	/	SYM
cusj-5588	516	27	ngf	ngf	ADJ
cusj-5588	516	28	expression	expression	NOUN
cusj-5588	516	29	for	for	ADP
cusj-5588	516	30	ad	ad	NOUN
cusj-5588	516	31	,	,	PUNCT
cusj-5588	516	32	dopaminergic	dopaminergic	ADJ
cusj-5588	516	33	phenotypes	phenotype	NOUN
cusj-5588	516	34	for	for	ADP
cusj-5588	516	35	pd	pd	NOUN
cusj-5588	516	36	,	,	PUNCT
cusj-5588	516	37	and	and	CCONJ
cusj-5588	516	38	msn	msn	VERB
cusj-5588	516	39	for	for	ADP
cusj-5588	516	40	hd	hd	PROPN
cusj-5588	516	41	)	)	PUNCT
cusj-5588	516	42	;	;	PUNCT
cusj-5588	516	43	however	however	ADV
cusj-5588	516	44	,	,	PUNCT
cusj-5588	516	45	these	these	DET
cusj-5588	516	46	induced	induce	VERB
cusj-5588	516	47	populations	population	NOUN
cusj-5588	516	48	are	be	AUX
cusj-5588	516	49	usually	usually	ADV
cusj-5588	516	50	not	not	PART
cusj-5588	516	51	pure	pure	ADJ
cusj-5588	516	52	,	,	PUNCT
cusj-5588	516	53	long	long	ADJ
cusj-5588	516	54	-	-	PUNCT
cusj-5588	516	55	term	term	NOUN
cusj-5588	516	56	graft	graft	NOUN
cusj-5588	516	57	survival	survival	NOUN
cusj-5588	516	58	is	be	AUX
cusj-5588	516	59	generally	generally	ADV
cusj-5588	516	60	low	low	ADJ
cusj-5588	516	61	,	,	PUNCT
cusj-5588	516	62	and	and	CCONJ
cusj-5588	516	63	any	any	DET
cusj-5588	516	64	es	e	NOUN
cusj-5588	516	65	cells	cell	NOUN
cusj-5588	516	66	escaping	escape	VERB
cusj-5588	516	67	in	in	ADP
cusj-5588	516	68	vitro	vitro	ADJ
cusj-5588	516	69	differentiation	differentiation	NOUN
cusj-5588	516	70	carries	carry	VERB
cusj-5588	516	71	the	the	DET
cusj-5588	516	72	potential	potential	ADJ
cusj-5588	516	73	or	or	CCONJ
cusj-5588	516	74	yielding	yield	VERB
cusj-5588	516	75	teratomas	teratoma	NOUN
cusj-5588	516	76	and	and	CCONJ
cusj-5588	516	77	tumours	tumour	NOUN
cusj-5588	516	78	following	follow	VERB
cusj-5588	516	79	transplantation	transplantation	NOUN
cusj-5588	516	80	.	.	PUNCT
cusj-5588	517	1	above	above	ADP
cusj-5588	517	2	all	all	PRON
cusj-5588	517	3	,	,	PUNCT
cusj-5588	517	4	the	the	DET
cusj-5588	517	5	development	development	NOUN
cusj-5588	517	6	of	of	ADP
cusj-5588	517	7	effective	effective	ADJ
cusj-5588	517	8	stem	stem	NOUN
cusj-5588	517	9	cell	cell	NOUN
cusj-5588	517	10	-	-	PUNCT
cusj-5588	517	11	based	base	VERB
cusj-5588	517	12	therapies	therapy	NOUN
cusj-5588	517	13	is	be	AUX
cusj-5588	517	14	ultimately	ultimately	ADV
cusj-5588	517	15	hindered	hinder	VERB
cusj-5588	517	16	by	by	ADP
cusj-5588	517	17	our	our	PRON
cusj-5588	517	18	current	current	ADJ
cusj-5588	517	19	lack	lack	NOUN
cusj-5588	517	20	of	of	ADP
cusj-5588	517	21	knowledge	knowledge	NOUN
cusj-5588	517	22	on	on	ADP
cusj-5588	517	23	the	the	DET
cusj-5588	517	24	mechanisms	mechanism	NOUN
cusj-5588	517	25	of	of	ADP
cusj-5588	517	26	action	action	NOUN
cusj-5588	517	27	of	of	ADP
cusj-5588	517	28	transplanted	transplanted	ADJ
cusj-5588	517	29	stem	stem	NOUN
cusj-5588	517	30	cells	cell	NOUN
cusj-5588	517	31	,	,	PUNCT
cusj-5588	517	32	and	and	CCONJ
cusj-5588	517	33	how	how	SCONJ
cusj-5588	517	34	stem	stem	NOUN
cusj-5588	517	35	cell	cell	NOUN
cusj-5588	517	36	proliferation	proliferation	NOUN
cusj-5588	517	37	,	,	PUNCT
cusj-5588	517	38	differentiation	differentiation	NOUN
cusj-5588	517	39	,	,	PUNCT
cusj-5588	517	40	survival	survival	NOUN
cusj-5588	517	41	,	,	PUNCT
cusj-5588	517	42	and	and	CCONJ
cusj-5588	517	43	migration	migration	NOUN
cusj-5588	517	44	are	be	AUX
cusj-5588	517	45	controlled	control	VERB
cusj-5588	517	46	in	in	ADP
cusj-5588	517	47	a	a	DET
cusj-5588	517	48	pathological	pathological	ADJ
cusj-5588	517	49	environment	environment	NOUN
cusj-5588	517	50	.	.	PUNCT
cusj-5588	518	1	the	the	DET
cusj-5588	518	2	mechanisms	mechanism	NOUN
cusj-5588	518	3	of	of	ADP
cusj-5588	518	4	cellular	cellular	ADJ
cusj-5588	518	5	protection	protection	NOUN
cusj-5588	518	6	provided	provide	VERB
cusj-5588	518	7	by	by	ADP
cusj-5588	518	8	sc	sc	PROPN
cusj-5588	518	9	-	-	PUNCT
cusj-5588	518	10	mediated	mediate	VERB
cusj-5588	518	11	trophic	trophic	ADJ
cusj-5588	518	12	support	support	NOUN
cusj-5588	518	13	are	be	AUX
cusj-5588	518	14	also	also	ADV
cusj-5588	518	15	not	not	PART
cusj-5588	518	16	fully	fully	ADV
cusj-5588	518	17	understood	understand	VERB
cusj-5588	518	18	(	(	PUNCT
cusj-5588	518	19	mcbride	mcbride	PROPN
cusj-5588	518	20	et	et	PROPN
cusj-5588	518	21	al	al	PROPN
cusj-5588	518	22	.	.	PROPN
cusj-5588	518	23	,	,	PUNCT
cusj-5588	518	24	2004	2004	NUM
cusj-5588	518	25	)	)	PUNCT
cusj-5588	518	26	.	.	PUNCT
cusj-5588	519	1	because	because	SCONJ
cusj-5588	519	2	current	current	ADJ
cusj-5588	519	3	potential	potential	ADJ
cusj-5588	519	4	risks	risk	NOUN
cusj-5588	519	5	outweigh	outweigh	VERB
cusj-5588	519	6	validated	validate	VERB
cusj-5588	519	7	benefits	benefit	NOUN
cusj-5588	519	8	in	in	ADP
cusj-5588	519	9	their	their	PRON
cusj-5588	519	10	therapeutic	therapeutic	ADJ
cusj-5588	519	11	applications	application	NOUN
cusj-5588	519	12	,	,	PUNCT
cusj-5588	519	13	research	research	NOUN
cusj-5588	519	14	on	on	ADP
cusj-5588	519	15	human	human	ADJ
cusj-5588	519	16	stem	stem	NOUN
cusj-5588	519	17	cells	cell	NOUN
cusj-5588	519	18	and	and	CCONJ
cusj-5588	519	19	patientderived	patientderive	VERB
cusj-5588	519	20	ipscs	ipscs	NOUN
cusj-5588	519	21	should	should	AUX
cusj-5588	519	22	first	first	ADV
cusj-5588	519	23	be	be	AUX
cusj-5588	519	24	focused	focus	VERB
cusj-5588	519	25	on	on	ADP
cusj-5588	519	26	disease	disease	NOUN
cusj-5588	519	27	modelling	modelling	NOUN
cusj-5588	519	28	and	and	CCONJ
cusj-5588	519	29	used	use	VERB
cusj-5588	519	30	for	for	ADP
cusj-5588	519	31	screening	screen	VERB
cusj-5588	519	32	drugs	drug	NOUN
cusj-5588	519	33	and	and	CCONJ
cusj-5588	519	34	other	other	ADJ
cusj-5588	519	35	therapeutics	therapeutic	NOUN
cusj-5588	519	36	.	.	PUNCT
cusj-5588	520	1	successful	successful	ADJ
cusj-5588	520	2	development	development	NOUN
cusj-5588	520	3	of	of	ADP
cusj-5588	520	4	clinical	clinical	ADJ
cusj-5588	520	5	therapies	therapy	NOUN
cusj-5588	520	6	can	can	AUX
cusj-5588	520	7	begin	begin	VERB
cusj-5588	520	8	once	once	ADV
cusj-5588	520	9	more	more	ADV
cusj-5588	520	10	precise	precise	ADJ
cusj-5588	520	11	disease	disease	NOUN
cusj-5588	520	12	pathophysiologies	pathophysiologie	NOUN
cusj-5588	520	13	and	and	CCONJ
cusj-5588	520	14	mechanisms	mechanism	NOUN
cusj-5588	520	15	of	of	ADP
cusj-5588	520	16	sc	sc	PROPN
cusj-5588	520	17	action	action	NOUN
cusj-5588	520	18	post	post	NOUN
cusj-5588	520	19	-	-	NOUN
cusj-5588	520	20	transplantation	transplantation	NOUN
cusj-5588	520	21	are	be	AUX
cusj-5588	520	22	identified	identify	VERB
cusj-5588	520	23	.	.	PUNCT
cusj-5588	521	1	in	in	ADP
cusj-5588	521	2	sum	sum	NOUN
cusj-5588	521	3	,	,	PUNCT
cusj-5588	521	4	the	the	DET
cusj-5588	521	5	use	use	NOUN
cusj-5588	521	6	of	of	ADP
cusj-5588	521	7	stem	stem	NOUN
cusj-5588	521	8	cells	cell	NOUN
cusj-5588	521	9	for	for	ADP
cusj-5588	521	10	transplantation	transplantation	NOUN
cusj-5588	521	11	has	have	AUX
cusj-5588	521	12	generated	generate	VERB
cusj-5588	521	13	enormous	enormous	ADJ
cusj-5588	521	14	ethical	ethical	ADJ
cusj-5588	521	15	,	,	PUNCT
cusj-5588	521	16	technical	technical	ADJ
cusj-5588	521	17	,	,	PUNCT
cusj-5588	521	18	efficacy	efficacy	NOUN
cusj-5588	521	19	,	,	PUNCT
cusj-5588	521	20	and	and	CCONJ
cusj-5588	521	21	safetyrelated	safetyrelated	ADJ
cusj-5588	521	22	debates	debate	NOUN
cusj-5588	521	23	.	.	PUNCT
cusj-5588	522	1	it	it	PRON
cusj-5588	522	2	is	be	AUX
cusj-5588	522	3	true	true	ADJ
cusj-5588	522	4	that	that	SCONJ
cusj-5588	522	5	sc	sc	PROPN
cusj-5588	522	6	replacement	replacement	NOUN
cusj-5588	522	7	therapy	therapy	NOUN
cusj-5588	522	8	can	can	AUX
cusj-5588	522	9	stabilize	stabilize	VERB
cusj-5588	522	10	and	and	CCONJ
cusj-5588	522	11	regenerate	regenerate	VERB
cusj-5588	522	12	entire	entire	ADJ
cusj-5588	522	13	networks	network	NOUN
cusj-5588	522	14	of	of	ADP
cusj-5588	522	15	neuronal	neuronal	ADJ
cusj-5588	522	16	loss	loss	NOUN
cusj-5588	522	17	and	and	CCONJ
cusj-5588	522	18	prevent	prevent	VERB
cusj-5588	522	19	further	further	ADJ
cusj-5588	522	20	neurodegeneration	neurodegeneration	NOUN
cusj-5588	522	21	by	by	ADP
cusj-5588	522	22	providing	provide	VERB
cusj-5588	522	23	environmental	environmental	ADJ
cusj-5588	522	24	and	and	CCONJ
cusj-5588	522	25	trophic	trophic	ADJ
cusj-5588	522	26	factors	factor	NOUN
cusj-5588	522	27	against	against	ADP
cusj-5588	522	28	toxic	toxic	ADJ
cusj-5588	522	29	,	,	PUNCT
cusj-5588	522	30	neurodegenerative	neurodegenerative	ADJ
cusj-5588	522	31	factors	factor	NOUN
cusj-5588	522	32	.	.	PUNCT
cusj-5588	523	1	however	however	ADV
cusj-5588	523	2	,	,	PUNCT
cusj-5588	523	3	with	with	ADP
cusj-5588	523	4	current	current	ADJ
cusj-5588	523	5	literature	literature	NOUN
cusj-5588	523	6	,	,	PUNCT
cusj-5588	523	7	the	the	DET
cusj-5588	523	8	greatest	great	ADJ
cusj-5588	523	9	functionally	functionally	ADV
cusj-5588	523	10	validated	validate	VERB
cusj-5588	523	11	potential	potential	NOUN
cusj-5588	523	12	of	of	ADP
cusj-5588	523	13	scs	scs	PROPN
cusj-5588	523	14	lies	lie	NOUN
cusj-5588	523	15	in	in	ADP
cusj-5588	523	16	their	their	PRON
cusj-5588	523	17	unique	unique	ADJ
cusj-5588	523	18	ability	ability	NOUN
cusj-5588	523	19	to	to	PART
cusj-5588	523	20	model	model	VERB
cusj-5588	523	21	disease	disease	NOUN
cusj-5588	523	22	pathophysiology	pathophysiology	NOUN
cusj-5588	523	23	and	and	CCONJ
cusj-5588	523	24	mechanisms	mechanism	NOUN
cusj-5588	523	25	of	of	ADP
cusj-5588	523	26	action	action	NOUN
cusj-5588	523	27	.	.	PUNCT
cusj-5588	524	1	patient	patient	NOUN
cusj-5588	524	2	-	-	PUNCT
cusj-5588	524	3	derived	derive	VERB
cusj-5588	524	4	ipsc	ipsc	NOUN
cusj-5588	524	5	cells	cell	NOUN
cusj-5588	524	6	may	may	AUX
cusj-5588	524	7	be	be	AUX
cusj-5588	524	8	a	a	DET
cusj-5588	524	9	particularly	particularly	ADV
cusj-5588	524	10	tremendous	tremendous	ADJ
cusj-5588	524	11	treatment	treatment	NOUN
cusj-5588	524	12	option	option	NOUN
cusj-5588	524	13	for	for	ADP
cusj-5588	524	14	personalized	personalized	ADJ
cusj-5588	524	15	medicine	medicine	NOUN
cusj-5588	524	16	in	in	ADP
cusj-5588	524	17	the	the	DET
cusj-5588	524	18	future	future	NOUN
cusj-5588	524	19	,	,	PUNCT
cusj-5588	524	20	but	but	CCONJ
cusj-5588	524	21	for	for	ADP
cusj-5588	524	22	now	now	ADV
cusj-5588	524	23	serve	serve	VERB
cusj-5588	524	24	as	as	ADP
cusj-5588	524	25	prominent	prominent	ADJ
cusj-5588	524	26	tools	tool	NOUN
cusj-5588	524	27	for	for	ADP
cusj-5588	524	28	understanding	understand	VERB
cusj-5588	524	29	disease	disease	NOUN
cusj-5588	524	30	etiology	etiology	NOUN
cusj-5588	524	31	on	on	ADP
cusj-5588	524	32	a	a	DET
cusj-5588	524	33	highly	highly	ADV
cusj-5588	524	34	personalized	personalized	ADJ
cusj-5588	524	35	level	level	NOUN
cusj-5588	524	36	,	,	PUNCT
cusj-5588	524	37	as	as	SCONJ
cusj-5588	524	38	they	they	PRON
cusj-5588	524	39	carry	carry	VERB
cusj-5588	524	40	the	the	DET
cusj-5588	524	41	patient	patient	NOUN
cusj-5588	524	42	’s	’s	PART
cusj-5588	524	43	genotype	genotype	NOUN
cusj-5588	524	44	,	,	PUNCT
cusj-5588	524	45	disease	disease	NOUN
cusj-5588	524	46	mutations	mutation	NOUN
cusj-5588	524	47	,	,	PUNCT
cusj-5588	524	48	and	and	CCONJ
cusj-5588	524	49	also	also	ADV
cusj-5588	524	50	account	account	VERB
cusj-5588	524	51	for	for	ADP
cusj-5588	524	52	environmental	environmental	ADJ
cusj-5588	524	53	influences	influence	NOUN
cusj-5588	524	54	on	on	ADP
cusj-5588	524	55	the	the	DET
cusj-5588	524	56	individual	individual	NOUN
cusj-5588	524	57	’s	’s	PART
cusj-5588	524	58	disease	disease	NOUN
cusj-5588	524	59	.	.	PUNCT
cusj-5588	525	1	part	part	NOUN
cusj-5588	525	2	4	4	NUM
cusj-5588	525	3	:	:	PUNCT
cusj-5588	525	4	precision	precision	NOUN
cusj-5588	525	5	medicine	medicine	NOUN
cusj-5588	525	6	&	&	CCONJ
cusj-5588	525	7	biomarkers	biomarker	NOUN
cusj-5588	525	8	in	in	ADP
cusj-5588	525	9	discussing	discuss	VERB
cusj-5588	525	10	future	future	ADJ
cusj-5588	525	11	developments	development	NOUN
cusj-5588	525	12	of	of	ADP
cusj-5588	525	13	neurodegenerative	neurodegenerative	ADJ
cusj-5588	525	14	therapies	therapy	NOUN
cusj-5588	525	15	,	,	PUNCT
cusj-5588	525	16	it	it	PRON
cusj-5588	525	17	is	be	AUX
cusj-5588	525	18	critical	critical	ADJ
cusj-5588	525	19	to	to	PART
cusj-5588	525	20	emphasize	emphasize	VERB
cusj-5588	525	21	the	the	DET
cusj-5588	525	22	importance	importance	NOUN
cusj-5588	525	23	of	of	ADP
cusj-5588	525	24	elucidating	elucidate	VERB
cusj-5588	525	25	the	the	DET
cusj-5588	525	26	molecular	molecular	ADJ
cusj-5588	525	27	etiologies	etiology	NOUN
cusj-5588	525	28	of	of	ADP
cusj-5588	525	29	nds	nds	PROPN
cusj-5588	525	30	.	.	PROPN
cusj-5588	525	31	pathologically	pathologically	ADV
cusj-5588	525	32	altered	alter	VERB
cusj-5588	525	33	proteins	protein	NOUN
cusj-5588	525	34	and	and	CCONJ
cusj-5588	525	35	protein	protein	NOUN
cusj-5588	525	36	aggregations	aggregation	NOUN
cusj-5588	525	37	are	be	AUX
cusj-5588	525	38	fundamental	fundamental	ADJ
cusj-5588	525	39	characteristics	characteristic	NOUN
cusj-5588	525	40	of	of	ADP
cusj-5588	525	41	neurodegenerative	neurodegenerative	ADJ
cusj-5588	525	42	diseases	disease	NOUN
cusj-5588	525	43	and	and	CCONJ
cusj-5588	525	44	should	should	AUX
cusj-5588	525	45	be	be	AUX
cusj-5588	525	46	of	of	ADP
cusj-5588	525	47	paramount	paramount	ADJ
cusj-5588	525	48	focus	focus	NOUN
cusj-5588	525	49	for	for	ADP
cusj-5588	525	50	further	further	ADJ
cusj-5588	525	51	research	research	NOUN
cusj-5588	525	52	.	.	PUNCT
cusj-5588	526	1	i	i	PRON
cusj-5588	526	2	’ve	’ve	AUX
cusj-5588	526	3	alluded	allude	VERB
cusj-5588	526	4	to	to	ADP
cusj-5588	526	5	the	the	DET
cusj-5588	526	6	importance	importance	NOUN
cusj-5588	526	7	of	of	ADP
cusj-5588	526	8	biomarker	biomarker	NOUN
cusj-5588	526	9	research	research	NOUN
cusj-5588	526	10	in	in	ADP
cusj-5588	526	11	aiding	aid	VERB
cusj-5588	526	12	developments	development	NOUN
cusj-5588	526	13	of	of	ADP
cusj-5588	526	14	novel	novel	ADJ
cusj-5588	526	15	therapies	therapy	NOUN
cusj-5588	526	16	during	during	ADP
cusj-5588	526	17	part	part	NOUN
cusj-5588	526	18	2	2	NUM
cusj-5588	526	19	&	&	CCONJ
cusj-5588	526	20	3	3	NUM
cusj-5588	526	21	’s	’s	PART
cusj-5588	526	22	discussion	discussion	NOUN
cusj-5588	526	23	of	of	ADP
cusj-5588	526	24	gene	gene	NOUN
cusj-5588	526	25	therapy	therapy	NOUN
cusj-5588	526	26	and	and	CCONJ
cusj-5588	526	27	stem	stem	NOUN
cusj-5588	526	28	-	-	PUNCT
cusj-5588	526	29	cell	cell	NOUN
cusj-5588	526	30	based	base	VERB
cusj-5588	526	31	treatments	treatment	NOUN
cusj-5588	526	32	.	.	PUNCT
cusj-5588	527	1	this	this	PRON
cusj-5588	527	2	is	be	AUX
cusj-5588	527	3	because	because	SCONJ
cusj-5588	527	4	molecular	molecular	ADJ
cusj-5588	527	5	classifications	classification	NOUN
cusj-5588	527	6	of	of	ADP
cusj-5588	527	7	nds	nds	PROPN
cusj-5588	527	8	can	can	AUX
cusj-5588	527	9	detail	detail	VERB
cusj-5588	527	10	the	the	DET
cusj-5588	527	11	nature	nature	NOUN
cusj-5588	527	12	of	of	ADP
cusj-5588	527	13	pathologically	pathologically	ADV
cusj-5588	527	14	dysfunctional	dysfunctional	ADJ
cusj-5588	527	15	proteins	protein	NOUN
cusj-5588	527	16	and	and	CCONJ
cusj-5588	527	17	correlate	correlate	VERB
cusj-5588	527	18	corresponding	corresponding	ADJ
cusj-5588	527	19	clinical	clinical	ADJ
cusj-5588	527	20	symptoms	symptom	NOUN
cusj-5588	527	21	to	to	ADP
cusj-5588	527	22	genetic	genetic	ADJ
cusj-5588	527	23	abnormalities	abnormality	NOUN
cusj-5588	527	24	.	.	PUNCT
cusj-5588	528	1	ongoing	ongoing	ADJ
cusj-5588	528	2	biomarker	biomarker	NOUN
cusj-5588	528	3	research	research	NOUN
cusj-5588	528	4	has	have	AUX
cusj-5588	528	5	already	already	ADV
cusj-5588	528	6	identified	identify	VERB
cusj-5588	528	7	extracellular	extracellular	ADJ
cusj-5588	528	8	deposits	deposit	NOUN
cusj-5588	528	9	of	of	ADP
cusj-5588	528	10	a	a	DET
cusj-5588	528	11	fibrils	fibril	NOUN
cusj-5588	528	12	and	and	CCONJ
cusj-5588	528	13	aggregation	aggregation	NOUN
cusj-5588	528	14	of	of	ADP
cusj-5588	528	15	abnormally	abnormally	ADV
cusj-5588	528	16	-	-	PUNCT
cusj-5588	528	17	phosphorylated	phosphorylate	VERB
cusj-5588	528	18	tau	tau	NOUN
cusj-5588	528	19	proteins	protein	NOUN
cusj-5588	528	20	in	in	ADP
cusj-5588	528	21	ad	ad	NOUN
cusj-5588	528	22	,	,	PUNCT
cusj-5588	528	23	the	the	DET
cusj-5588	528	24	presence	presence	NOUN
cusj-5588	528	25	of	of	ADP
cusj-5588	528	26	lewy	lewy	PROPN
cusj-5588	528	27	body	body	NOUN
cusj-5588	528	28	deposits	deposit	NOUN
cusj-5588	528	29	,	,	PUNCT
cusj-5588	528	30	altered	alter	VERB
cusj-5588	528	31	dopamine	dopamine	NOUN
cusj-5588	528	32	transporters	transporter	NOUN
cusj-5588	528	33	in	in	ADP
cusj-5588	528	34	pd	pd	PROPN
cusj-5588	528	35	,	,	PUNCT
cusj-5588	528	36	and	and	CCONJ
cusj-5588	528	37	protein	protein	NOUN
cusj-5588	528	38	misfolding	misfolding	NOUN
cusj-5588	528	39	and	and	CCONJ
cusj-5588	528	40	aggregation	aggregation	NOUN
cusj-5588	528	41	associated	associate	VERB
cusj-5588	528	42	with	with	ADP
cusj-5588	528	43	mhtt	mhtt	PROPN
cusj-5588	528	44	proteins	protein	NOUN
cusj-5588	528	45	in	in	ADP
cusj-5588	528	46	hd	hd	PROPN
cusj-5588	528	47	(	(	PUNCT
cusj-5588	528	48	kovacs	kovacs	PROPN
cusj-5588	528	49	,	,	PUNCT
cusj-5588	528	50	2016	2016	NUM
cusj-5588	528	51	)	)	PUNCT
cusj-5588	528	52	.	.	PUNCT
cusj-5588	529	1	thus	thus	ADV
cusj-5588	529	2	,	,	PUNCT
cusj-5588	529	3	the	the	DET
cusj-5588	529	4	ability	ability	NOUN
cusj-5588	529	5	of	of	ADP
cusj-5588	529	6	biomarker	biomarker	NOUN
cusj-5588	529	7	data	datum	NOUN
cusj-5588	529	8	to	to	PART
cusj-5588	529	9	identify	identify	VERB
cusj-5588	529	10	core	core	NOUN
cusj-5588	529	11	disease	disease	NOUN
cusj-5588	529	12	pathology	pathology	NOUN
cusj-5588	529	13	has	have	AUX
cusj-5588	529	14	already	already	ADV
cusj-5588	529	15	been	be	AUX
cusj-5588	529	16	validated	validate	VERB
cusj-5588	529	17	,	,	PUNCT
cusj-5588	529	18	and	and	CCONJ
cusj-5588	529	19	therapies	therapy	NOUN
cusj-5588	529	20	targeting	target	VERB
cusj-5588	529	21	these	these	DET
cusj-5588	529	22	protein	protein	NOUN
cusj-5588	529	23	abnormalities	abnormality	NOUN
cusj-5588	529	24	(	(	PUNCT
cusj-5588	529	25	through	through	ADP
cusj-5588	529	26	immunotherapy	immunotherapy	NOUN
cusj-5588	529	27	,	,	PUNCT
cusj-5588	529	28	gene	gene	NOUN
cusj-5588	529	29	therapy	therapy	NOUN
cusj-5588	529	30	,	,	PUNCT
cusj-5588	529	31	sc	sc	NOUN
cusj-5588	529	32	-	-	PUNCT
cusj-5588	529	33	transplants	transplant	NOUN
cusj-5588	529	34	)	)	PUNCT
cusj-5588	529	35	have	have	AUX
cusj-5588	529	36	yielded	yield	VERB
cusj-5588	529	37	promising	promising	ADJ
cusj-5588	529	38	results	result	NOUN
cusj-5588	529	39	in	in	ADP
cusj-5588	529	40	animal	animal	NOUN
cusj-5588	529	41	and	and	CCONJ
cusj-5588	529	42	some	some	DET
cusj-5588	529	43	clinical	clinical	ADJ
cusj-5588	529	44	models	model	NOUN
cusj-5588	529	45	.	.	PUNCT
cusj-5588	530	1	however	however	ADV
cusj-5588	530	2	,	,	PUNCT
cusj-5588	530	3	the	the	DET
cusj-5588	530	4	most	most	ADV
cusj-5588	530	5	exciting	exciting	ADJ
cusj-5588	530	6	potential	potential	NOUN
cusj-5588	530	7	of	of	ADP
cusj-5588	530	8	biomarker	biomarker	NOUN
cusj-5588	530	9	research	research	NOUN
cusj-5588	530	10	lies	lie	VERB
cusj-5588	530	11	in	in	ADP
cusj-5588	530	12	its	its	PRON
cusj-5588	530	13	ability	ability	NOUN
cusj-5588	530	14	to	to	PART
cusj-5588	530	15	characterise	characterise	VERB
cusj-5588	530	16	patient	patient	NOUN
cusj-5588	530	17	-	-	PUNCT
cusj-5588	530	18	specific	specific	ADJ
cusj-5588	530	19	environment	environment	NOUN
cusj-5588	530	20	-	-	PUNCT
cusj-5588	530	21	disease	disease	NOUN
cusj-5588	530	22	dynamics	dynamic	NOUN
cusj-5588	530	23	and	and	CCONJ
cusj-5588	530	24	gene	gene	NOUN
cusj-5588	530	25	variations	variation	NOUN
cusj-5588	530	26	,	,	PUNCT
cusj-5588	530	27	and	and	CCONJ
cusj-5588	530	28	consequently	consequently	ADV
cusj-5588	530	29	provide	provide	VERB
cusj-5588	530	30	personalized	personalized	ADJ
cusj-5588	530	31	diagnoses	diagnosis	NOUN
cusj-5588	530	32	.	.	PUNCT
cusj-5588	531	1	in	in	ADP
cusj-5588	531	2	the	the	DET
cusj-5588	531	3	emerging	emerge	VERB
cusj-5588	531	4	era	era	NOUN
cusj-5588	531	5	of	of	ADP
cusj-5588	531	6	precision	precision	NOUN
cusj-5588	531	7	medicine	medicine	NOUN
cusj-5588	531	8	,	,	PUNCT
cusj-5588	531	9	the	the	DET
cusj-5588	531	10	use	use	NOUN
cusj-5588	531	11	of	of	ADP
cusj-5588	531	12	biomarkers	biomarker	NOUN
cusj-5588	531	13	(	(	PUNCT
cusj-5588	531	14	detected	detect	VERB
cusj-5588	531	15	in	in	ADP
cusj-5588	531	16	body	body	NOUN
cusj-5588	531	17	fluids	fluid	NOUN
cusj-5588	531	18	or	or	CCONJ
cusj-5588	531	19	pet	pet	ADJ
cusj-5588	531	20	imaging	imaging	NOUN
cusj-5588	531	21	)	)	PUNCT
cusj-5588	531	22	can	can	AUX
cusj-5588	531	23	provide	provide	VERB
cusj-5588	531	24	earlier	early	ADV
cusj-5588	531	25	and	and	CCONJ
cusj-5588	531	26	more	more	ADV
cusj-5588	531	27	accurate	accurate	ADJ
cusj-5588	531	28	nd	nd	PRON
cusj-5588	531	29	diagnosis	diagnosis	NOUN
cusj-5588	531	30	,	,	PUNCT
cusj-5588	531	31	and	and	CCONJ
cusj-5588	531	32	their	their	PRON
cusj-5588	531	33	identified	identify	VERB
cusj-5588	531	34	protein	protein	NOUN
cusj-5588	531	35	dysfunctions	dysfunction	NOUN
cusj-5588	531	36	can	can	AUX
cusj-5588	531	37	be	be	AUX
cusj-5588	531	38	targeted	target	VERB
cusj-5588	531	39	in	in	ADP
cusj-5588	531	40	translational	translational	ADJ
cusj-5588	531	41	research	research	NOUN
cusj-5588	531	42	using	use	VERB
cusj-5588	531	43	novel	novel	ADJ
cusj-5588	531	44	therapies	therapy	NOUN
cusj-5588	531	45	.	.	PUNCT
cusj-5588	532	1	looking	look	VERB
cusj-5588	532	2	forward	forward	ADV
cusj-5588	532	3	,	,	PUNCT
cusj-5588	532	4	biomarker	biomarker	NOUN
cusj-5588	532	5	research	research	NOUN
cusj-5588	532	6	will	will	AUX
cusj-5588	532	7	contribute	contribute	VERB
cusj-5588	532	8	greatly	greatly	ADV
cusj-5588	532	9	to	to	ADP
cusj-5588	532	10	developing	develop	VERB
cusj-5588	532	11	pathophysiological	pathophysiological	ADJ
cusj-5588	532	12	disease	disease	NOUN
cusj-5588	532	13	models	model	NOUN
cusj-5588	532	14	,	,	PUNCT
cusj-5588	532	15	improving	improve	VERB
cusj-5588	532	16	immunotherapy	immunotherapy	NOUN
cusj-5588	532	17	,	,	PUNCT
cusj-5588	532	18	gene	gene	NOUN
cusj-5588	532	19	therapy	therapy	NOUN
cusj-5588	532	20	and	and	CCONJ
cusj-5588	532	21	sc	sc	PROPN
cusj-5588	532	22	-	-	PUNCT
cusj-5588	532	23	based	base	VERB
cusj-5588	532	24	transplant	transplant	NOUN
cusj-5588	532	25	methods	method	NOUN
cusj-5588	532	26	,	,	PUNCT
cusj-5588	532	27	and	and	CCONJ
cusj-5588	532	28	moving	move	VERB
cusj-5588	532	29	us	we	PRON
cusj-5588	532	30	closer	close	ADV
cusj-5588	532	31	to	to	AUX
cusj-5588	532	32	personalized	personalize	VERB
cusj-5588	532	33	14	14	NUM
cusj-5588	532	34	_	_	PUNCT
cusj-5588	533	1	_	_	PUNCT
cusj-5588	534	1	_	_	PUNCT
cusj-5588	535	1	_	_	PUNCT
cusj-5588	536	1	_	_	PUNCT
cusj-5588	537	1	_	_	PUNCT
cusj-5588	538	1	_	_	PUNCT
cusj-5588	539	1	_	_	PUNCT
cusj-5588	540	1	_	_	PUNCT
cusj-5588	541	1	_	_	PUNCT
cusj-5588	542	1	_	_	PUNCT
cusj-5588	543	1	_	_	PUNCT
cusj-5588	544	1	_	_	PUNCT
cusj-5588	545	1	_	_	PUNCT
cusj-5588	546	1	_	_	PUNCT
cusj-5588	547	1	_	_	PUNCT
cusj-5588	548	1	_	_	PUNCT
cusj-5588	549	1	_	_	PUNCT
cusj-5588	550	1	_	_	PUNCT
cusj-5588	551	1	_	_	PUNCT
cusj-5588	552	1	_	_	PUNCT
cusj-5588	553	1	_	_	PUNCT
cusj-5588	554	1	_	_	PUNCT
cusj-5588	555	1	_	_	PUNCT
cusj-5588	556	1	_	_	PUNCT
cusj-5588	557	1	_	_	PUNCT
cusj-5588	558	1	_	_	PUNCT
cusj-5588	559	1	_	_	PUNCT
cusj-5588	560	1	_	_	PUNCT
cusj-5588	561	1	_	_	PUNCT
cusj-5588	562	1	_	_	PUNCT
cusj-5588	563	1	_	_	PUNCT
cusj-5588	564	1	_	_	PUNCT
cusj-5588	565	1	_	_	PUNCT
cusj-5588	566	1	_	_	PUNCT
cusj-5588	567	1	_	_	PUNCT
cusj-5588	568	1	_	_	PUNCT
cusj-5588	569	1	_	_	PUNCT
cusj-5588	570	1	_	_	PUNCT
cusj-5588	571	1	_	_	PUNCT
cusj-5588	572	1	_	_	PUNCT
cusj-5588	573	1	_	_	PUNCT
cusj-5588	574	1	_	_	PUNCT
cusj-5588	575	1	_	_	PUNCT
cusj-5588	576	1	_	_	PUNCT
cusj-5588	577	1	_	_	PUNCT
cusj-5588	578	1	_	_	PUNCT
cusj-5588	579	1	_	_	PUNCT
cusj-5588	580	1	_	_	PUNCT
cusj-5588	581	1	_	_	PUNCT
cusj-5588	582	1	_	_	PUNCT
cusj-5588	583	1	_	_	PUNCT
cusj-5588	584	1	_	_	PUNCT
cusj-5588	585	1	_	_	PUNCT
cusj-5588	586	1	_	_	PUNCT
cusj-5588	587	1	_	_	PUNCT
cusj-5588	588	1	_	_	PUNCT
cusj-5588	589	1	_	_	PUNCT
cusj-5588	590	1	_	_	PUNCT
cusj-5588	591	1	_	_	PUNCT
cusj-5588	592	1	_	_	PUNCT
cusj-5588	593	1	_	_	PUNCT
cusj-5588	594	1	_	_	PUNCT
cusj-5588	595	1	_	_	PUNCT
cusj-5588	596	1	_	_	PUNCT
cusj-5588	597	1	_	_	PUNCT
cusj-5588	598	1	_	_	PUNCT
cusj-5588	599	1	_	_	PUNCT
cusj-5588	600	1	_	_	PUNCT
cusj-5588	601	1	_	_	PUNCT
cusj-5588	602	1	_	_	PUNCT
cusj-5588	603	1	_	_	PUNCT
cusj-5588	604	1	_	_	PUNCT
cusj-5588	605	1	_	_	PUNCT
cusj-5588	606	1	_	_	PUNCT
cusj-5588	607	1	_	_	PUNCT
cusj-5588	608	1	_	_	PUNCT
cusj-5588	609	1	_	_	PUNCT
cusj-5588	610	1	_	_	PUNCT
cusj-5588	611	1	_	_	PUNCT
cusj-5588	611	2	cusj	cusj	VERB
cusj-5588	611	3	2018	2018	NUM
cusj-5588	611	4	cures	cure	NOUN
cusj-5588	611	5	for	for	ADP
cusj-5588	611	6	neurodegenerative	neurodegenerative	ADJ
cusj-5588	611	7	diseases	disease	NOUN
cusj-5588	611	8	.	.	PUNCT
cusj-5588	612	1	similarly	similarly	ADV
cusj-5588	612	2	,	,	PUNCT
cusj-5588	612	3	stem	stem	NOUN
cusj-5588	612	4	cell	cell	NOUN
cusj-5588	612	5	research	research	NOUN
cusj-5588	612	6	can	can	AUX
cusj-5588	612	7	be	be	AUX
cusj-5588	612	8	applied	apply	VERB
cusj-5588	612	9	to	to	ADP
cusj-5588	612	10	experimentally	experimentally	ADV
cusj-5588	612	11	model	model	NOUN
cusj-5588	612	12	nds	nds	PROPN
cusj-5588	612	13	.	.	PUNCT
cusj-5588	612	14	patient	patient	NOUN
cusj-5588	612	15	-	-	PUNCT
cusj-5588	612	16	derived	derive	VERB
cusj-5588	612	17	ipscs	ipscs	NOUN
cusj-5588	612	18	are	be	AUX
cusj-5588	612	19	especially	especially	ADV
cusj-5588	612	20	well	well	ADV
cusj-5588	612	21	-	-	PUNCT
cusj-5588	612	22	suited	suited	ADJ
cusj-5588	612	23	to	to	PART
cusj-5588	612	24	uncover	uncover	VERB
cusj-5588	612	25	specific	specific	ADJ
cusj-5588	612	26	disease	disease	NOUN
cusj-5588	612	27	pathophysiologies	pathophysiologie	NOUN
cusj-5588	612	28	as	as	SCONJ
cusj-5588	612	29	they	they	PRON
cusj-5588	612	30	carry	carry	VERB
cusj-5588	612	31	the	the	DET
cusj-5588	612	32	patient	patient	NOUN
cusj-5588	612	33	’s	’s	PART
cusj-5588	612	34	genotype	genotype	NOUN
cusj-5588	612	35	and	and	CCONJ
cusj-5588	612	36	bear	bear	VERB
cusj-5588	612	37	patient	patient	NOUN
cusj-5588	612	38	-	-	PUNCT
cusj-5588	612	39	specific	specific	ADJ
cusj-5588	612	40	disease	disease	NOUN
cusj-5588	612	41	mutations	mutation	NOUN
cusj-5588	612	42	and	and	CCONJ
cusj-5588	612	43	gene	gene	NOUN
cusj-5588	612	44	-	-	PUNCT
cusj-5588	612	45	environment	environment	NOUN
cusj-5588	612	46	interactions	interaction	NOUN
cusj-5588	612	47	.	.	PUNCT
cusj-5588	613	1	thus	thus	ADV
cusj-5588	613	2	,	,	PUNCT
cusj-5588	613	3	i	i	PRON
cusj-5588	613	4	believe	believe	VERB
cusj-5588	613	5	that	that	SCONJ
cusj-5588	613	6	research	research	NOUN
cusj-5588	613	7	focusing	focus	VERB
cusj-5588	613	8	on	on	ADP
cusj-5588	613	9	biomarkers	biomarker	NOUN
cusj-5588	613	10	,	,	PUNCT
cusj-5588	613	11	patientderived	patientderived	ADJ
cusj-5588	613	12	ipscs	ipsc	NOUN
cusj-5588	613	13	,	,	PUNCT
cusj-5588	613	14	and	and	CCONJ
cusj-5588	613	15	genetic	genetic	ADJ
cusj-5588	613	16	studies	study	NOUN
cusj-5588	613	17	are	be	AUX
cusj-5588	613	18	currently	currently	ADV
cusj-5588	613	19	most	most	ADV
cusj-5588	613	20	necessary	necessary	ADJ
cusj-5588	613	21	and	and	CCONJ
cusj-5588	613	22	potentially	potentially	ADV
cusj-5588	613	23	most	most	ADV
cusj-5588	613	24	beneficial	beneficial	ADJ
cusj-5588	613	25	for	for	ADP
cusj-5588	613	26	current	current	ADJ
cusj-5588	613	27	experimental	experimental	ADJ
cusj-5588	613	28	and	and	CCONJ
cusj-5588	613	29	clinical	clinical	ADJ
cusj-5588	613	30	endeavours	endeavour	NOUN
cusj-5588	613	31	for	for	ADP
cusj-5588	613	32	nd	nd	NOUN
cusj-5588	613	33	cures	cure	NOUN
cusj-5588	613	34	.	.	PUNCT
cusj-5588	614	1	table	table	NOUN
cusj-5588	614	2	1	1	NUM
cusj-5588	614	3	:	:	PUNCT
cusj-5588	614	4	overview	overview	NOUN
cusj-5588	614	5	of	of	ADP
cusj-5588	614	6	neurodegenerative	neurodegenerative	ADJ
cusj-5588	614	7	disorders	disorder	NOUN
cusj-5588	614	8	disorder	disorder	NOUN
cusj-5588	614	9	~incidence	~incidence	NOUN
cusj-5588	614	10	(	(	PUNCT
cusj-5588	614	11	total	total	NOUN
cusj-5588	614	12	in	in	ADP
cusj-5588	614	13	us	we	PRON
cusj-5588	614	14	)	)	PUNCT
cusj-5588	614	15	brain	brain	NOUN
cusj-5588	614	16	region	region	NOUN
cusj-5588	614	17	affected	affect	VERB
cusj-5588	614	18	molecular	molecular	ADJ
cusj-5588	614	19	changes	change	NOUN
cusj-5588	614	20	symptoms	symptom	NOUN
cusj-5588	614	21	alzheimer	alzheimer	PROPN
cusj-5588	614	22	’s	’s	PART
cusj-5588	614	23	disease	disease	NOUN
cusj-5588	614	24	(	(	PUNCT
cusj-5588	614	25	ad	ad	NOUN
cusj-5588	614	26	)	)	PUNCT
cusj-5588	614	27	5,000,000	5,000,000	NUM
cusj-5588	614	28	hippocampus	hippocampus	NOUN
cusj-5588	614	29	,	,	PUNCT
cusj-5588	614	30	amygdala	amygdala	NOUN
cusj-5588	614	31	,	,	PUNCT
cusj-5588	614	32	neocortex	neocortex	NOUN
cusj-5588	614	33	,	,	PUNCT
cusj-5588	614	34	basal	basal	ADJ
cusj-5588	614	35	forebrain	forebrain	NOUN
cusj-5588	614	36	·	·	SYM
cusj-5588	614	37	neurofibrillary	neurofibrillary	ADJ
cusj-5588	614	38	tangles	tangle	NOUN
cusj-5588	614	39	(	(	PUNCT
cusj-5588	614	40	hyperphosphorylation	hyperphosphorylation	NOUN
cusj-5588	614	41	of	of	ADP
cusj-5588	614	42	tau	tau	PROPN
cusj-5588	614	43	proteins	protein	NOUN
cusj-5588	614	44	)	)	PUNCT
cusj-5588	614	45	·	·	PUNCT
cusj-5588	614	46	β	β	X
cusj-5588	614	47	-	-	ADJ
cusj-5588	614	48	amyloid	amyloid	ADJ
cusj-5588	614	49	plaques	plaque	NOUN
cusj-5588	614	50	(	(	PUNCT
cusj-5588	614	51	amyloid	amyloid	NOUN
cusj-5588	614	52	peptide	peptide	NOUN
cusj-5588	614	53	aggregates	aggregate	NOUN
cusj-5588	614	54	)	)	PUNCT
cusj-5588	614	55	dementia	dementia	NOUN
cusj-5588	614	56	(	(	PUNCT
cusj-5588	614	57	cognitive	cognitive	ADJ
cusj-5588	614	58	,	,	PUNCT
cusj-5588	614	59	psychiatric	psychiatric	ADJ
cusj-5588	614	60	,	,	PUNCT
cusj-5588	614	61	behavioural	behavioural	ADJ
cusj-5588	614	62	)	)	PUNCT
cusj-5588	614	63	amyotrophic	amyotrophic	ADJ
cusj-5588	614	64	lateral	lateral	ADJ
cusj-5588	614	65	sclerosis	sclerosis	NOUN
cusj-5588	614	66	(	(	PUNCT
cusj-5588	614	67	als	als	NOUN
cusj-5588	614	68	)	)	PUNCT
cusj-5588	614	69	30,000	30,000	NUM
cusj-5588	614	70	motor	motor	NOUN
cusj-5588	614	71	neurons	neuron	NOUN
cusj-5588	614	72	·	·	PUNCT
cusj-5588	614	73	motor	motor	NOUN
cusj-5588	614	74	neuron	neuron	NOUN
cusj-5588	614	75	degeneration	degeneration	NOUN
cusj-5588	614	76	in	in	ADP
cusj-5588	614	77	spinal	spinal	ADJ
cusj-5588	614	78	cord	cord	NOUN
cusj-5588	614	79	,	,	PUNCT
cusj-5588	614	80	brain	brain	NOUN
cusj-5588	614	81	stem	stem	NOUN
cusj-5588	614	82	,	,	PUNCT
cusj-5588	614	83	primary	primary	ADJ
cusj-5588	614	84	motor	motor	NOUN
cusj-5588	614	85	cortex	cortex	NOUN
cusj-5588	614	86	difficulty	difficulty	NOUN
cusj-5588	614	87	walking	walk	VERB
cusj-5588	614	88	,	,	PUNCT
cusj-5588	614	89	weakness	weakness	NOUN
cusj-5588	614	90	in	in	ADP
cusj-5588	614	91	limbs	limb	NOUN
cusj-5588	614	92	/	/	SYM
cusj-5588	614	93	arms	arm	NOUN
cusj-5588	614	94	,	,	PUNCT
cusj-5588	614	95	slurred	slurred	ADJ
cusj-5588	614	96	speech	speech	NOUN
cusj-5588	614	97	,	,	PUNCT
cusj-5588	614	98	muscle	muscle	NOUN
cusj-5588	614	99	cramps	cramp	NOUN
cusj-5588	614	100	and	and	CCONJ
cusj-5588	614	101	twitching	twitch	VERB
cusj-5588	614	102	parkinson	parkinson	NOUN
cusj-5588	614	103	’s	’s	PART
cusj-5588	614	104	disease	disease	NOUN
cusj-5588	614	105	(	(	PUNCT
cusj-5588	614	106	pd	pd	NOUN
cusj-5588	614	107	)	)	PUNCT
cusj-5588	614	108	1,000,000	1,000,000	NUM
cusj-5588	614	109	substantia	substantia	NOUN
cusj-5588	614	110	nigra	nigra	NOUN
cusj-5588	614	111	·	·	PUNCT
cusj-5588	614	112	dopaminergic	dopaminergic	ADJ
cusj-5588	614	113	neuron	neuron	NOUN
cusj-5588	614	114	loss	loss	NOUN
cusj-5588	614	115	from	from	ADP
cusj-5588	614	116	nigrostriatum	nigrostriatum	ADJ
cusj-5588	614	117	and	and	CCONJ
cusj-5588	614	118	substantia	substantia	NOUN
cusj-5588	614	119	nigra	nigra	NOUN
cusj-5588	614	120	pars	par	NOUN
cusj-5588	614	121	·	·	PUNCT
cusj-5588	614	122	build	build	VERB
cusj-5588	614	123	-	-	PUNCT
cusj-5588	614	124	up	up	NOUN
cusj-5588	614	125	of	of	ADP
cusj-5588	614	126	lewy	lewy	PROPN
cusj-5588	614	127	bodies	body	NOUN
cusj-5588	614	128	,	,	PUNCT
cusj-5588	614	129	α	α	X
cusj-5588	614	130	-	-	PUNCT
cusj-5588	614	131	synuclein	synuclein	NOUN
cusj-5588	614	132	aggregates	aggregate	NOUN
cusj-5588	614	133	tremors	tremor	NOUN
cusj-5588	614	134	,	,	PUNCT
cusj-5588	614	135	bradykinesia	bradykinesia	PROPN
cusj-5588	614	136	,	,	PUNCT
cusj-5588	614	137	impaired	impaired	ADJ
cusj-5588	614	138	balance	balance	NOUN
cusj-5588	614	139	and	and	CCONJ
cusj-5588	614	140	posture	posture	NOUN
cusj-5588	614	141	,	,	PUNCT
cusj-5588	614	142	loss	loss	NOUN
cusj-5588	614	143	of	of	ADP
cusj-5588	614	144	automatic	automatic	ADJ
cusj-5588	614	145	movements	movement	NOUN
cusj-5588	614	146	huntington	huntington	PROPN
cusj-5588	614	147	’s	’s	PART
cusj-5588	614	148	disease	disease	NOUN
cusj-5588	614	149	(	(	PUNCT
cusj-5588	614	150	hd	hd	NOUN
cusj-5588	614	151	)	)	PUNCT
cusj-5588	614	152	30,000	30,000	NUM
cusj-5588	614	153	basal	basal	ADJ
cusj-5588	614	154	ganglia	ganglia	NOUN
cusj-5588	614	155	,	,	PUNCT
cusj-5588	614	156	neostriatum	neostriatum	NOUN
cusj-5588	614	157	·	·	PUNCT
cusj-5588	614	158	trinucleotide	trinucleotide	NOUN
cusj-5588	614	159	(	(	PUNCT
cusj-5588	614	160	cag	cag	PROPN
cusj-5588	614	161	)	)	PUNCT
cusj-5588	614	162	repeat	repeat	NOUN
cusj-5588	614	163	in	in	ADP
cusj-5588	614	164	iti5	iti5	PROPN
cusj-5588	614	165	huntington	huntington	PROPN
cusj-5588	614	166	gene	gene	PROPN
cusj-5588	614	167	·	·	PUNCT
cusj-5588	614	168	loss	loss	NOUN
cusj-5588	614	169	of	of	ADP
cusj-5588	614	170	medium	medium	ADJ
cusj-5588	614	171	spiny	spiny	ADJ
cusj-5588	614	172	neurons	neuron	NOUN
cusj-5588	614	173	(	(	PUNCT
cusj-5588	614	174	msn	msn	NOUN
cusj-5588	614	175	)	)	PUNCT
cusj-5588	614	176	·	·	PUNCT
cusj-5588	614	177	toxicity	toxicity	NOUN
cusj-5588	614	178	of	of	ADP
cusj-5588	614	179	mhtt	mhtt	NOUN
cusj-5588	614	180	:	:	PUNCT
cusj-5588	614	181	protein	protein	NOUN
cusj-5588	614	182	misfolding	misfolding	NOUN
cusj-5588	614	183	&	&	CCONJ
cusj-5588	614	184	aggregation	aggregation	NOUN
cusj-5588	614	185	muscle	muscle	NOUN
cusj-5588	614	186	problems	problem	NOUN
cusj-5588	614	187	(	(	PUNCT
cusj-5588	614	188	rigidity	rigidity	NOUN
cusj-5588	614	189	,	,	PUNCT
cusj-5588	614	190	dystonia	dystonia	NOUN
cusj-5588	614	191	)	)	PUNCT
cusj-5588	614	192	,	,	PUNCT
cusj-5588	614	193	involuntary	involuntary	ADJ
cusj-5588	614	194	jerking	jerking	ADJ
cusj-5588	614	195	movements	movement	NOUN
cusj-5588	614	196	,	,	PUNCT
cusj-5588	614	197	abnormal	abnormal	ADJ
cusj-5588	614	198	eye	eye	NOUN
cusj-5588	614	199	movements	movement	NOUN
cusj-5588	614	200	spinal	spinal	VERB
cusj-5588	614	201	muscular	muscular	ADJ
cusj-5588	614	202	atrophy	atrophy	NOUN
cusj-5588	614	203	(	(	PUNCT
cusj-5588	614	204	sma	sma	PROPN
cusj-5588	614	205	)	)	PUNCT
cusj-5588	614	206	9,000	9,000	NUM
cusj-5588	614	207	motor	motor	NOUN
cusj-5588	614	208	neurons	neuron	NOUN
cusj-5588	614	209	mutations	mutation	NOUN
cusj-5588	614	210	in	in	ADP
cusj-5588	614	211	smn1	smn1	NOUN
cusj-5588	614	212	gene	gene	NOUN
cusj-5588	614	213	muscular	muscular	ADJ
cusj-5588	614	214	atrophy	atrophy	NOUN
cusj-5588	614	215	,	,	PUNCT
cusj-5588	614	216	balance	balance	NOUN
cusj-5588	614	217	and	and	CCONJ
cusj-5588	614	218	coordination	coordination	NOUN
cusj-5588	614	219	deficits	deficit	NOUN
cusj-5588	614	220	table	table	NOUN
cusj-5588	614	221	2	2	NUM
cusj-5588	614	222	:	:	PUNCT
cusj-5588	614	223	current	current	ADJ
cusj-5588	614	224	therapies	therapy	NOUN
cusj-5588	614	225	for	for	ADP
cusj-5588	614	226	ad	ad	NOUN
cusj-5588	614	227	,	,	PUNCT
cusj-5588	614	228	pd	pd	PROPN
cusj-5588	614	229	,	,	PUNCT
cusj-5588	614	230	&	&	CCONJ
cusj-5588	614	231	hd	hd	PROPN
cusj-5588	614	232	disease	disease	NOUN
cusj-5588	614	233	pharmacological	pharmacological	NOUN
cusj-5588	614	234	treatments	treatment	NOUN
cusj-5588	614	235	other	other	ADJ
cusj-5588	614	236	treatments	treatment	NOUN
cusj-5588	614	237	alzheimer	alzheimer	PROPN
cusj-5588	614	238	’s	’s	PART
cusj-5588	614	239	disease	disease	NOUN
cusj-5588	614	240	·	·	PUNCT
cusj-5588	614	241	acetylcholinesterase	acetylcholinesterase	NOUN
cusj-5588	614	242	inhibitors	inhibitor	NOUN
cusj-5588	614	243	(	(	PUNCT
cusj-5588	614	244	donepezil	donepezil	NOUN
cusj-5588	614	245	,	,	PUNCT
cusj-5588	614	246	galantamine	galantamine	NOUN
cusj-5588	614	247	,	,	PUNCT
cusj-5588	614	248	rivastigamine	rivastigamine	NOUN
cusj-5588	614	249	,	,	PUNCT
cusj-5588	614	250	tacrine	tacrine	NOUN
cusj-5588	614	251	)	)	PUNCT
cusj-5588	614	252	·	·	PUNCT
cusj-5588	614	253	nmda	nmda	ADJ
cusj-5588	614	254	receptor	receptor	NOUN
cusj-5588	614	255	antagonist	antagonist	NOUN
cusj-5588	614	256	(	(	PUNCT
cusj-5588	614	257	memantine	memantine	NOUN
cusj-5588	614	258	)	)	PUNCT
cusj-5588	614	259	·	·	PUNCT
cusj-5588	614	260	caregiving	caregive	VERB
cusj-5588	614	261	·	·	PUNCT
cusj-5588	614	262	behavioural	behavioural	ADJ
cusj-5588	614	263	therapy	therapy	NOUN
cusj-5588	614	264	(	(	PUNCT
cusj-5588	614	265	reduce	reduce	VERB
cusj-5588	614	266	problem	problem	NOUN
cusj-5588	614	267	behaviours	behaviour	NOUN
cusj-5588	614	268	)	)	PUNCT
cusj-5588	614	269	·	·	PUNCT
cusj-5588	614	270	psychosocial	psychosocial	ADJ
cusj-5588	614	271	interventions	intervention	NOUN
cusj-5588	614	272	(	(	PUNCT
cusj-5588	614	273	emotion	emotion	NOUN
cusj-5588	614	274	and	and	CCONJ
cusj-5588	614	275	cognition	cognition	NOUN
cusj-5588	614	276	regulation	regulation	NOUN
cusj-5588	614	277	)	)	PUNCT
cusj-5588	614	278	parkinson	parkinson	NOUN
cusj-5588	614	279	’s	’s	PART
cusj-5588	614	280	disease	disease	NOUN
cusj-5588	614	281	dopamine	dopamine	NOUN
cusj-5588	614	282	replacement	replacement	NOUN
cusj-5588	614	283	(	(	PUNCT
cusj-5588	614	284	levodopa	levodopa	NOUN
cusj-5588	614	285	,	,	PUNCT
cusj-5588	614	286	carbidopa	carbidopa	NOUN
cusj-5588	614	287	,	,	PUNCT
cusj-5588	614	288	selegeline	selegeline	NOUN
cusj-5588	614	289	)	)	PUNCT
cusj-5588	614	290	·	·	PUNCT
cusj-5588	614	291	deep	deep	ADJ
cusj-5588	614	292	brain	brain	NOUN
cusj-5588	614	293	stimulation	stimulation	NOUN
cusj-5588	614	294	(	(	PUNCT
cusj-5588	614	295	of	of	ADP
cusj-5588	614	296	thalamus	thalamus	NOUN
cusj-5588	614	297	,	,	PUNCT
cusj-5588	614	298	globus	globus	ADJ
cusj-5588	614	299	pallidus	pallidus	NOUN
cusj-5588	614	300	,	,	PUNCT
cusj-5588	614	301	subthalamic	subthalamic	ADJ
cusj-5588	614	302	nucleus	nucleus	NOUN
cusj-5588	614	303	)	)	PUNCT
cusj-5588	614	304	·	·	PUNCT
cusj-5588	615	1	physical	physical	PROPN
cusj-5588	615	2	therapy	therapy	NOUN
cusj-5588	615	3	huntington	huntington	PROPN
cusj-5588	615	4	’s	’s	PART
cusj-5588	615	5	disease	disease	PROPN
cusj-5588	615	6	chorea	chorea	VERB
cusj-5588	615	7	treatment	treatment	NOUN
cusj-5588	615	8	(	(	PUNCT
cusj-5588	615	9	tetrabenazine	tetrabenazine	NOUN
cusj-5588	615	10	,	,	PUNCT
cusj-5588	615	11	benzodiazepines	benzodiazepine	NOUN
cusj-5588	615	12	,	,	PUNCT
cusj-5588	615	13	neuroleptics	neuroleptic	NOUN
cusj-5588	615	14	)	)	PUNCT
cusj-5588	615	15	·	·	PUNCT
cusj-5588	616	1	caregiving	caregive	VERB
cusj-5588	616	2	·	·	PUNCT
cusj-5588	616	3	physical	physical	ADJ
cusj-5588	616	4	therapy	therapy	NOUN
cusj-5588	616	5	·	·	PUNCT
cusj-5588	616	6	speech	speech	NOUN
cusj-5588	616	7	and	and	CCONJ
cusj-5588	616	8	language	language	NOUN
cusj-5588	616	9	therapy	therapy	NOUN
cusj-5588	616	10	15	15	NUM
cusj-5588	616	11	cusj	cusj	NOUN
cusj-5588	616	12	2018	2018	NUM
cusj-5588	616	13	_	_	PUNCT
cusj-5588	617	1	_	_	PUNCT
cusj-5588	618	1	_	_	PUNCT
cusj-5588	619	1	_	_	PUNCT
cusj-5588	620	1	_	_	PUNCT
cusj-5588	621	1	_	_	PUNCT
cusj-5588	622	1	_	_	PUNCT
cusj-5588	623	1	_	_	PUNCT
cusj-5588	624	1	_	_	PUNCT
cusj-5588	625	1	_	_	PUNCT
cusj-5588	626	1	_	_	PUNCT
cusj-5588	627	1	_	_	PUNCT
cusj-5588	628	1	_	_	PUNCT
cusj-5588	629	1	_	_	PUNCT
cusj-5588	630	1	_	_	PUNCT
cusj-5588	631	1	_	_	PUNCT
cusj-5588	632	1	_	_	PUNCT
cusj-5588	633	1	_	_	PUNCT
cusj-5588	634	1	_	_	PUNCT
cusj-5588	635	1	_	_	PUNCT
cusj-5588	636	1	_	_	PUNCT
cusj-5588	637	1	_	_	PUNCT
cusj-5588	638	1	_	_	PUNCT
cusj-5588	639	1	_	_	PUNCT
cusj-5588	640	1	_	_	PUNCT
cusj-5588	641	1	_	_	PUNCT
cusj-5588	642	1	_	_	PUNCT
cusj-5588	643	1	_	_	PUNCT
cusj-5588	644	1	_	_	PUNCT
cusj-5588	645	1	_	_	PUNCT
cusj-5588	646	1	_	_	PUNCT
cusj-5588	647	1	_	_	PUNCT
cusj-5588	648	1	_	_	PUNCT
cusj-5588	649	1	_	_	PUNCT
cusj-5588	650	1	_	_	PUNCT
cusj-5588	651	1	_	_	PUNCT
cusj-5588	652	1	_	_	PUNCT
cusj-5588	653	1	_	_	PUNCT
cusj-5588	654	1	_	_	PUNCT
cusj-5588	655	1	_	_	PUNCT
cusj-5588	656	1	_	_	PUNCT
cusj-5588	657	1	_	_	PUNCT
cusj-5588	658	1	_	_	PUNCT
cusj-5588	659	1	_	_	PUNCT
cusj-5588	660	1	_	_	PUNCT
cusj-5588	661	1	_	_	PUNCT
cusj-5588	662	1	_	_	PUNCT
cusj-5588	663	1	_	_	PUNCT
cusj-5588	664	1	_	_	PUNCT
cusj-5588	665	1	_	_	PUNCT
cusj-5588	666	1	_	_	PUNCT
cusj-5588	667	1	_	_	PUNCT
cusj-5588	668	1	_	_	PUNCT
cusj-5588	669	1	_	_	PUNCT
cusj-5588	670	1	_	_	PUNCT
cusj-5588	671	1	_	_	PUNCT
cusj-5588	672	1	_	_	PUNCT
cusj-5588	673	1	_	_	PUNCT
cusj-5588	674	1	_	_	PUNCT
cusj-5588	675	1	_	_	PUNCT
cusj-5588	676	1	_	_	PUNCT
cusj-5588	677	1	_	_	PUNCT
cusj-5588	678	1	_	_	PUNCT
cusj-5588	679	1	_	_	PUNCT
cusj-5588	680	1	_	_	PUNCT
cusj-5588	681	1	_	_	PUNCT
cusj-5588	682	1	_	_	PUNCT
cusj-5588	683	1	_	_	PUNCT
cusj-5588	684	1	_	_	PUNCT
cusj-5588	685	1	_	_	PUNCT
cusj-5588	686	1	_	_	PUNCT
cusj-5588	687	1	_	_	PUNCT
cusj-5588	688	1	_	_	PUNCT
cusj-5588	689	1	_	_	PUNCT
cusj-5588	690	1	_	_	PUNCT
cusj-5588	691	1	_	_	PUNCT
cusj-5588	692	1	_	_	PUNCT
cusj-5588	693	1	_	_	PUNCT
cusj-5588	694	1	_	_	PUNCT
cusj-5588	695	1	_	_	PUNCT
cusj-5588	695	2	table	table	NOUN
cusj-5588	695	3	3	3	NUM
cusj-5588	695	4	:	:	PUNCT
cusj-5588	695	5	viral	viral	ADJ
cusj-5588	695	6	vector	vector	NOUN
cusj-5588	695	7	-	-	PUNCT
cusj-5588	695	8	mediated	mediate	VERB
cusj-5588	695	9	gene	gene	NOUN
cusj-5588	695	10	therapies	therapy	NOUN
cusj-5588	695	11	(	(	PUNCT
cusj-5588	695	12	ad	ad	NOUN
cusj-5588	695	13	&	&	CCONJ
cusj-5588	695	14	pd	pd	PROPN
cusj-5588	695	15	)	)	PUNCT
cusj-5588	695	16	disease	disease	NOUN
cusj-5588	695	17	study	study	NOUN
cusj-5588	695	18	/	/	SYM
cusj-5588	695	19	trial	trial	NOUN
cusj-5588	695	20	codes	code	NOUN
cusj-5588	695	21	gene	gene	NOUN
cusj-5588	695	22	therapy	therapy	NOUN
cusj-5588	695	23	method	method	NOUN
cusj-5588	695	24	of	of	ADP
cusj-5588	695	25	delivery	delivery	NOUN
cusj-5588	695	26	current	current	ADJ
cusj-5588	695	27	status	status	NOUN
cusj-5588	695	28	alzheimer	alzheimer	PROPN
cusj-5588	695	29	’s	’s	PART
cusj-5588	695	30	disease	disease	NOUN
cusj-5588	695	31	rafii	rafii	VERB
cusj-5588	695	32	et	et	PROPN
cusj-5588	695	33	al	al	PROPN
cusj-5588	695	34	.	.	PROPN
cusj-5588	695	35	,	,	PUNCT
cusj-5588	695	36	2014	2014	NUM
cusj-5588	695	37	(	(	PUNCT
cusj-5588	695	38	nct00876863	nct00876863	NOUN
cusj-5588	695	39	)	)	PUNCT
cusj-5588	695	40	aav2	aav2	PROPN
cusj-5588	695	41	-	-	PUNCT
cusj-5588	695	42	ngf	ngf	ADV
cusj-5588	695	43	-	-	PUNCT
cusj-5588	695	44	ngf	ngf	NOUN
cusj-5588	695	45	:	:	PUNCT
cusj-5588	695	46	nerve	nerve	NOUN
cusj-5588	695	47	growth	growth	NOUN
cusj-5588	695	48	factor	factor	NOUN
cusj-5588	695	49	//	//	PUNCT
cusj-5588	695	50	dysregulated	dysregulate	VERB
cusj-5588	695	51	in	in	ADP
cusj-5588	695	52	ad	ad	NOUN
cusj-5588	695	53	,	,	PUNCT
cusj-5588	695	54	neuroprotector	neuroprotector	NOUN
cusj-5588	695	55	/	/	SYM
cusj-5588	695	56	cellular	cellular	ADJ
cusj-5588	695	57	therapy	therapy	NOUN
cusj-5588	695	58	efficacy	efficacy	NOUN
cusj-5588	695	59	injection	injection	NOUN
cusj-5588	695	60	into	into	ADP
cusj-5588	695	61	basal	basal	ADJ
cusj-5588	695	62	forebrain	forebrain	NOUN
cusj-5588	695	63	·	·	PUNCT
cusj-5588	695	64	phase	phase	NOUN
cusj-5588	695	65	1	1	NUM
cusj-5588	695	66	successful	successful	ADJ
cusj-5588	695	67	*	*	PUNCT
cusj-5588	695	68	,	,	PUNCT
cusj-5588	695	69	therapy	therapy	NOUN
cusj-5588	695	70	well	well	ADV
cusj-5588	695	71	-	-	PUNCT
cusj-5588	695	72	tolerated	tolerate	VERB
cusj-5588	695	73	,	,	PUNCT
cusj-5588	695	74	ngf	ngf	ADV
cusj-5588	695	75	-	-	PUNCT
cusj-5588	695	76	induced	induce	VERB
cusj-5588	695	77	axonal	axonal	ADJ
cusj-5588	695	78	sprouting	sprouting	NOUN
cusj-5588	695	79	observed	observed	ADJ
cusj-5588	695	80	·	·	PUNCT
cusj-5588	695	81	phase	phase	NOUN
cusj-5588	695	82	ii	ii	NOUN
cusj-5588	695	83	in	in	ADP
cusj-5588	695	84	progress	progress	NOUN
cusj-5588	695	85	*	*	PUNCT
cusj-5588	695	86	success	success	NOUN
cusj-5588	695	87	defined	define	VERB
cusj-5588	695	88	by	by	ADP
cusj-5588	695	89	meeting	meet	VERB
cusj-5588	695	90	safety	safety	NOUN
cusj-5588	695	91	requirements	requirement	NOUN
cusj-5588	695	92	and	and	CCONJ
cusj-5588	695	93	showing	show	VERB
cusj-5588	695	94	functional	functional	ADJ
cusj-5588	695	95	improvement	improvement	NOUN
cusj-5588	695	96	parkinson	parkinson	NOUN
cusj-5588	695	97	’s	’s	PART
cusj-5588	695	98	disease	disease	NOUN
cusj-5588	695	99	lewitt	lewitt	VERB
cusj-5588	695	100	et	et	PROPN
cusj-5588	695	101	al	al	PROPN
cusj-5588	695	102	.	.	PROPN
cusj-5588	695	103	,	,	PUNCT
cusj-5588	695	104	2011	2011	NUM
cusj-5588	695	105	(	(	PUNCT
cusj-5588	695	106	nct00643890	nct00643890	NOUN
cusj-5588	695	107	)	)	PUNCT
cusj-5588	695	108	aav2	aav2	PROPN
cusj-5588	695	109	-	-	PUNCT
cusj-5588	695	110	gad	gad	PROPN
cusj-5588	695	111	-	-	PUNCT
cusj-5588	695	112	gad	gad	PROPN
cusj-5588	695	113	:	:	PUNCT
cusj-5588	696	1	glutamic	glutamic	ADJ
cusj-5588	696	2	acid	acid	NOUN
cusj-5588	696	3	decarboxylase	decarboxylase	PROPN
cusj-5588	696	4	//	//	NOUN
cusj-5588	696	5	ratelimiting	ratelimite	VERB
cusj-5588	696	6	biosynthetic	biosynthetic	ADJ
cusj-5588	696	7	enzyme	enzyme	NOUN
cusj-5588	696	8	for	for	ADP
cusj-5588	696	9	gaba	gaba	NOUN
cusj-5588	696	10	,	,	PUNCT
cusj-5588	696	11	reduces	reduce	VERB
cusj-5588	696	12	excitoxicity	excitoxicity	NOUN
cusj-5588	696	13	injection	injection	NOUN
cusj-5588	696	14	into	into	ADP
cusj-5588	696	15	subthalamic	subthalamic	ADJ
cusj-5588	696	16	nucleus	nucleus	NOUN
cusj-5588	696	17	phase	phase	NOUN
cusj-5588	696	18	i	i	PRON
cusj-5588	696	19	&	&	CCONJ
cusj-5588	696	20	ii	ii	PROPN
cusj-5588	696	21	successful	successful	ADJ
cusj-5588	696	22	,	,	PUNCT
cusj-5588	696	23	but	but	CCONJ
cusj-5588	696	24	symptom	symptom	NOUN
cusj-5588	696	25	improvements	improvement	NOUN
cusj-5588	696	26	achieved	achieve	VERB
cusj-5588	696	27	were	be	AUX
cusj-5588	696	28	not	not	PART
cusj-5588	696	29	better	well	ADJ
cusj-5588	696	30	than	than	ADP
cusj-5588	696	31	current	current	ADJ
cusj-5588	696	32	standards	standard	NOUN
cusj-5588	696	33	of	of	ADP
cusj-5588	696	34	care	care	NOUN
cusj-5588	696	35	parkinson	parkinson	NOUN
cusj-5588	696	36	’s	’s	PART
cusj-5588	696	37	disease	disease	NOUN
cusj-5588	696	38	bartus	bartus	NOUN
cusj-5588	696	39	et	et	PROPN
cusj-5588	696	40	al	al	PROPN
cusj-5588	696	41	.	.	PROPN
cusj-5588	696	42	,	,	PUNCT
cusj-5588	696	43	2011	2011	NUM
cusj-5588	696	44	(	(	PUNCT
cusj-5588	696	45	nct00400634	nct00400634	ADV
cusj-5588	696	46	;	;	PUNCT
cusj-5588	696	47	nct00985517	nct00985517	PROPN
cusj-5588	696	48	)	)	PUNCT
cusj-5588	696	49	aav2	aav2	PROPN
cusj-5588	696	50	-	-	PUNCT
cusj-5588	696	51	nrtn	nrtn	NOUN
cusj-5588	696	52	-	-	PUNCT
cusj-5588	696	53	nrtn	nrtn	NOUN
cusj-5588	696	54	:	:	PUNCT
cusj-5588	696	55	neurturin	neurturin	PROPN
cusj-5588	696	56	//	//	PUNCT
cusj-5588	696	57	delivers	deliver	VERB
cusj-5588	696	58	support	support	NOUN
cusj-5588	696	59	to	to	ADP
cusj-5588	696	60	dopaminergic	dopaminergic	ADJ
cusj-5588	696	61	neurons	neuron	NOUN
cusj-5588	696	62	injection	injection	NOUN
cusj-5588	696	63	into	into	ADP
cusj-5588	696	64	striatum	striatum	NOUN
cusj-5588	696	65	&	&	CCONJ
cusj-5588	696	66	putamen	putaman	NOUN
cusj-5588	696	67	·	·	PUNCT
cusj-5588	696	68	phase	phase	NOUN
cusj-5588	696	69	i	i	PRON
cusj-5588	696	70	successful	successful	ADJ
cusj-5588	696	71	,	,	PUNCT
cusj-5588	696	72	observed	observe	VERB
cusj-5588	696	73	increased	increase	VERB
cusj-5588	696	74	nrtn	nrtn	NOUN
cusj-5588	696	75	expression	expression	NOUN
cusj-5588	696	76	·	·	PUNCT
cusj-5588	696	77	phase	phase	NOUN
cusj-5588	696	78	ii	ii	NOUN
cusj-5588	696	79	showed	show	VERB
cusj-5588	696	80	no	no	DET
cusj-5588	696	81	improvement	improvement	NOUN
cusj-5588	696	82	in	in	ADP
cusj-5588	696	83	clinical	clinical	ADJ
cusj-5588	696	84	outcome	outcome	NOUN
cusj-5588	696	85	over	over	ADP
cusj-5588	696	86	controls	control	NOUN
cusj-5588	696	87	parkinson	parkinson	NOUN
cusj-5588	696	88	’s	’s	PART
cusj-5588	696	89	disease	disease	NOUN
cusj-5588	696	90	azzouz	azzouz	VERB
cusj-5588	696	91	et	et	PROPN
cusj-5588	696	92	al	al	PROPN
cusj-5588	696	93	.	.	PROPN
cusj-5588	696	94	,	,	PUNCT
cusj-5588	696	95	2002	2002	NUM
cusj-5588	696	96	(	(	PUNCT
cusj-5588	696	97	nct00627588	nct00627588	X
cusj-5588	696	98	;	;	PUNCT
cusj-5588	696	99	nct01856439	nct01856439	ADJ
cusj-5588	696	100	)	)	PUNCT
cusj-5588	696	101	lentivirus	lentivirus	NOUN
cusj-5588	696	102	-	-	PUNCT
cusj-5588	696	103	th	th	NOUN
cusj-5588	696	104	,	,	PUNCT
cusj-5588	696	105	aadc	aadc	NOUN
cusj-5588	696	106	,	,	PUNCT
cusj-5588	696	107	gch1	gch1	PROPN
cusj-5588	696	108	(	(	PUNCT
cusj-5588	696	109	*	*	PUNCT
cusj-5588	696	110	exciting	exciting	ADJ
cusj-5588	696	111	tricistronic	tricistronic	ADJ
cusj-5588	696	112	vector	vector	NOUN
cusj-5588	696	113	:	:	PUNCT
cusj-5588	696	114	cells	cell	NOUN
cusj-5588	696	115	transduced	transduce	VERB
cusj-5588	696	116	express	express	VERB
cusj-5588	696	117	all	all	DET
cusj-5588	696	118	3	3	NUM
cusj-5588	696	119	enzymes	enzyme	NOUN
cusj-5588	696	120	)	)	PUNCT
cusj-5588	696	121	-	-	PUNCT
cusj-5588	696	122	th	th	NOUN
cusj-5588	696	123	:	:	PUNCT
cusj-5588	696	124	tyrosine	tyrosine	NOUN
cusj-5588	696	125	hydroxylase	hydroxylase	PROPN
cusj-5588	696	126	/	/	SYM
cusj-5588	696	127	aadc	aadc	PROPN
cusj-5588	696	128	:	:	PUNCT
cusj-5588	696	129	aromatic	aromatic	ADJ
cusj-5588	696	130	amino	amino	NOUN
cusj-5588	696	131	acid	acid	NOUN
cusj-5588	696	132	dopa	dopa	NOUN
cusj-5588	696	133	decarboxylase	decarboxylase	PROPN
cusj-5588	696	134	/	/	SYM
cusj-5588	696	135	gch1	gch1	PROPN
cusj-5588	696	136	:	:	PUNCT
cusj-5588	697	1	gtp	gtp	PROPN
cusj-5588	697	2	cyclohydrolase	cyclohydrolase	PROPN
cusj-5588	698	1	i	i	PRON
cusj-5588	698	2	//	//	NUM
cusj-5588	698	3	three	three	NUM
cusj-5588	698	4	genes	gene	NOUN
cusj-5588	698	5	encode	encode	ADJ
cusj-5588	698	6	rate	rate	NOUN
cusj-5588	698	7	-	-	PUNCT
cusj-5588	698	8	limiting	limit	VERB
cusj-5588	698	9	dopamine	dopamine	NOUN
cusj-5588	698	10	biosynthesis	biosynthesis	NOUN
cusj-5588	698	11	enzymes	enzyme	NOUN
cusj-5588	698	12	injection	injection	NOUN
cusj-5588	698	13	into	into	ADP
cusj-5588	698	14	striatum	striatum	NOUN
cusj-5588	698	15	&	&	CCONJ
cusj-5588	698	16	putamen	putaman	NOUN
cusj-5588	698	17	·	·	PUNCT
cusj-5588	698	18	phase	phase	NOUN
cusj-5588	699	1	i	i	PRON
cusj-5588	699	2	(	(	PUNCT
cusj-5588	699	3	open	open	ADJ
cusj-5588	699	4	label	label	NOUN
cusj-5588	699	5	)	)	PUNCT
cusj-5588	699	6	successful	successful	ADJ
cusj-5588	699	7	,	,	PUNCT
cusj-5588	699	8	improved	improved	ADJ
cusj-5588	699	9	motor	motor	NOUN
cusj-5588	699	10	function	function	NOUN
cusj-5588	699	11	correlating	correlate	VERB
cusj-5588	699	12	with	with	ADP
cusj-5588	699	13	increasing	increase	VERB
cusj-5588	699	14	dose	dose	NOUN
cusj-5588	699	15	·	·	PUNCT
cusj-5588	699	16	currently	currently	ADV
cusj-5588	699	17	optimizing	optimize	VERB
cusj-5588	699	18	delivery	delivery	NOUN
cusj-5588	699	19	method	method	NOUN
cusj-5588	699	20	before	before	ADP
cusj-5588	699	21	phase	phase	NOUN
cusj-5588	699	22	ii	ii	PROPN
cusj-5588	699	23	(	(	PUNCT
cusj-5588	699	24	double	double	ADJ
cusj-5588	699	25	-	-	PUNCT
cusj-5588	699	26	blinded	blind	VERB
cusj-5588	699	27	randomized	randomized	ADJ
cusj-5588	699	28	trial	trial	NOUN
cusj-5588	699	29	)	)	PUNCT
cusj-5588	699	30	parkinson	parkinson	NOUN
cusj-5588	699	31	’s	’s	PART
cusj-5588	699	32	disease	disease	NOUN
cusj-5588	699	33	muramatsu	muramatsu	VERB
cusj-5588	699	34	et	et	PROPN
cusj-5588	699	35	al	al	PROPN
cusj-5588	699	36	.	.	PROPN
cusj-5588	699	37	,	,	PUNCT
cusj-5588	699	38	2015	2015	NUM
cusj-5588	699	39	(	(	PUNCT
cusj-5588	699	40	nct02418598	nct02418598	NOUN
cusj-5588	699	41	)	)	PUNCT
cusj-5588	699	42	aav2	aav2	PROPN
cusj-5588	699	43	-	-	PUNCT
cusj-5588	699	44	aadc	aadc	NOUN
cusj-5588	699	45	-	-	PUNCT
cusj-5588	699	46	(	(	PUNCT
cusj-5588	699	47	as	as	SCONJ
cusj-5588	699	48	discussed	discuss	VERB
cusj-5588	699	49	above	above	ADV
cusj-5588	699	50	)	)	PUNCT
cusj-5588	699	51	injection	injection	NOUN
cusj-5588	699	52	into	into	ADP
cusj-5588	699	53	putamen	putaman	NOUN
cusj-5588	699	54	·	·	PUNCT
cusj-5588	699	55	phase	phase	NOUN
cusj-5588	699	56	i	i	PRON
cusj-5588	699	57	safety	safety	NOUN
cusj-5588	699	58	trial	trial	NOUN
cusj-5588	699	59	successful	successful	ADJ
cusj-5588	699	60	,	,	PUNCT
cusj-5588	699	61	stable	stable	ADJ
cusj-5588	699	62	aadc	aadc	NOUN
cusj-5588	699	63	expression	expression	NOUN
cusj-5588	699	64	4	4	NUM
cusj-5588	699	65	years	year	NOUN
cusj-5588	699	66	postdelivery	postdelivery	NOUN
cusj-5588	699	67	·	·	PUNCT
cusj-5588	699	68	phase	phase	NOUN
cusj-5588	699	69	ii	ii	NOUN
cusj-5588	699	70	recruiting	recruiting	NOUN
cusj-5588	699	71	,	,	PUNCT
cusj-5588	699	72	in	in	ADP
cusj-5588	699	73	progress	progress	NOUN
cusj-5588	699	74	parkinson	parkinson	NOUN
cusj-5588	699	75	’s	’s	PART
cusj-5588	699	76	disease	disease	NOUN
cusj-5588	699	77	(	(	PUNCT
cusj-5588	699	78	nct00229736	nct00229736	NOUN
cusj-5588	699	79	)	)	PUNCT
cusj-5588	699	80	aav2	aav2	PROPN
cusj-5588	699	81	-	-	PUNCT
cusj-5588	699	82	aadc	aadc	NOUN
cusj-5588	699	83	intrastriatal	intrastriatal	ADJ
cusj-5588	699	84	infusion	infusion	NOUN
cusj-5588	699	85	·	·	PUNCT
cusj-5588	699	86	phase	phase	NOUN
cusj-5588	699	87	i	i	PRON
cusj-5588	699	88	safety	safety	NOUN
cusj-5588	699	89	trial	trial	NOUN
cusj-5588	699	90	successful	successful	ADJ
cusj-5588	699	91	16	16	NUM
cusj-5588	700	1	_	_	PUNCT
cusj-5588	701	1	_	_	PUNCT
cusj-5588	702	1	_	_	PUNCT
cusj-5588	703	1	_	_	PUNCT
cusj-5588	704	1	_	_	PUNCT
cusj-5588	705	1	_	_	PUNCT
cusj-5588	706	1	_	_	PUNCT
cusj-5588	707	1	_	_	PUNCT
cusj-5588	708	1	_	_	PUNCT
cusj-5588	709	1	_	_	PUNCT
cusj-5588	710	1	_	_	PUNCT
cusj-5588	711	1	_	_	PUNCT
cusj-5588	712	1	_	_	PUNCT
cusj-5588	713	1	_	_	PUNCT
cusj-5588	714	1	_	_	PUNCT
cusj-5588	715	1	_	_	PUNCT
cusj-5588	716	1	_	_	PUNCT
cusj-5588	717	1	_	_	PUNCT
cusj-5588	718	1	_	_	PUNCT
cusj-5588	719	1	_	_	PUNCT
cusj-5588	720	1	_	_	PUNCT
cusj-5588	721	1	_	_	PUNCT
cusj-5588	722	1	_	_	PUNCT
cusj-5588	723	1	_	_	PUNCT
cusj-5588	724	1	_	_	PUNCT
cusj-5588	725	1	_	_	PUNCT
cusj-5588	726	1	_	_	PUNCT
cusj-5588	727	1	_	_	PUNCT
cusj-5588	728	1	_	_	PUNCT
cusj-5588	729	1	_	_	PUNCT
cusj-5588	730	1	_	_	PUNCT
cusj-5588	731	1	_	_	PUNCT
cusj-5588	732	1	_	_	PUNCT
cusj-5588	733	1	_	_	PUNCT
cusj-5588	734	1	_	_	PUNCT
cusj-5588	735	1	_	_	PUNCT
cusj-5588	736	1	_	_	PUNCT
cusj-5588	737	1	_	_	PUNCT
cusj-5588	738	1	_	_	PUNCT
cusj-5588	739	1	_	_	PUNCT
cusj-5588	740	1	_	_	PUNCT
cusj-5588	741	1	_	_	PUNCT
cusj-5588	742	1	_	_	PUNCT
cusj-5588	743	1	_	_	PUNCT
cusj-5588	744	1	_	_	PUNCT
cusj-5588	745	1	_	_	PUNCT
cusj-5588	746	1	_	_	PUNCT
cusj-5588	747	1	_	_	PUNCT
cusj-5588	748	1	_	_	PUNCT
cusj-5588	749	1	_	_	PUNCT
cusj-5588	750	1	_	_	PUNCT
cusj-5588	751	1	_	_	PUNCT
cusj-5588	752	1	_	_	PUNCT
cusj-5588	753	1	_	_	PUNCT
cusj-5588	754	1	_	_	PUNCT
cusj-5588	755	1	_	_	PUNCT
cusj-5588	756	1	_	_	PUNCT
cusj-5588	757	1	_	_	PUNCT
cusj-5588	758	1	_	_	PUNCT
cusj-5588	759	1	_	_	PUNCT
cusj-5588	760	1	_	_	PUNCT
cusj-5588	761	1	_	_	PUNCT
cusj-5588	762	1	_	_	PUNCT
cusj-5588	763	1	_	_	PUNCT
cusj-5588	764	1	_	_	PUNCT
cusj-5588	765	1	_	_	PUNCT
cusj-5588	766	1	_	_	PUNCT
cusj-5588	767	1	_	_	PUNCT
cusj-5588	768	1	_	_	PUNCT
cusj-5588	769	1	_	_	PUNCT
cusj-5588	770	1	_	_	PUNCT
cusj-5588	771	1	_	_	PUNCT
cusj-5588	772	1	_	_	PUNCT
cusj-5588	773	1	_	_	PUNCT
cusj-5588	774	1	_	_	PUNCT
cusj-5588	775	1	_	_	PUNCT
cusj-5588	776	1	_	_	PUNCT
cusj-5588	777	1	_	_	PUNCT
cusj-5588	778	1	_	_	PUNCT
cusj-5588	779	1	_	_	PUNCT
cusj-5588	779	2	cusj	cusj	VERB
cusj-5588	779	3	2018	2018	NUM
cusj-5588	779	4	table	table	NOUN
cusj-5588	779	5	4	4	NUM
cusj-5588	779	6	:	:	PUNCT
cusj-5588	779	7	overview	overview	NOUN
cusj-5588	779	8	of	of	ADP
cusj-5588	779	9	current	current	ADJ
cusj-5588	779	10	literature	literature	NOUN
cusj-5588	779	11	on	on	ADP
cusj-5588	779	12	sc	sc	PROPN
cusj-5588	779	13	-	-	PUNCT
cusj-5588	779	14	based	base	VERB
cusj-5588	779	15	nd	nd	NOUN
cusj-5588	779	16	therapies	therapy	NOUN
cusj-5588	779	17	disease	disease	NOUN
cusj-5588	779	18	stem	stem	NOUN
cusj-5588	779	19	cell	cell	NOUN
cusj-5588	779	20	applications	application	NOUN
cusj-5588	779	21	goal	goal	NOUN
cusj-5588	779	22	of	of	ADP
cusj-5588	779	23	sc	sc	PROPN
cusj-5588	779	24	-	-	PUNCT
cusj-5588	779	25	based	base	VERB
cusj-5588	779	26	therapies	therapy	NOUN
cusj-5588	779	27	current	current	ADJ
cusj-5588	779	28	therapeutic	therapeutic	ADJ
cusj-5588	779	29	progress	progress	NOUN
cusj-5588	779	30	alzheimer	alzheimer	PROPN
cusj-5588	779	31	’s	’s	PART
cusj-5588	779	32	disease	disease	NOUN
cusj-5588	779	33	·	·	PUNCT
cusj-5588	779	34	nscs	nscs	ADJ
cusj-5588	779	35	·	·	PUNCT
cusj-5588	779	36	escs	esc	NOUN
cusj-5588	779	37	·	·	PUNCT
cusj-5588	779	38	restore	restore	VERB
cusj-5588	779	39	loss	loss	NOUN
cusj-5588	779	40	of	of	ADP
cusj-5588	779	41	cholinergic	cholinergic	ADJ
cusj-5588	779	42	neurons	neuron	NOUN
cusj-5588	779	43	·	·	PUNCT
cusj-5588	779	44	increase	increase	VERB
cusj-5588	779	45	bdnf	bdnf	PROPN
cusj-5588	779	46	&	&	CCONJ
cusj-5588	779	47	ngf	ngf	PROPN
cusj-5588	779	48	trophic	trophic	ADJ
cusj-5588	779	49	factors	factor	NOUN
cusj-5588	779	50	to	to	PART
cusj-5588	779	51	promote	promote	VERB
cusj-5588	779	52	neurogenesis	neurogenesis	NOUN
cusj-5588	779	53	·	·	PUNCT
cusj-5588	779	54	successful	successful	ADJ
cusj-5588	779	55	basal	basal	NOUN
cusj-5588	779	56	forebrain	forebrain	NOUN
cusj-5588	779	57	grafts	graft	NOUN
cusj-5588	779	58	of	of	ADP
cusj-5588	779	59	ngfsecreting	ngfsecrete	VERB
cusj-5588	779	60	fibroblasts	fibroblast	NOUN
cusj-5588	779	61	(	(	PUNCT
cusj-5588	779	62	open	open	ADJ
cusj-5588	779	63	-	-	PUNCT
cusj-5588	779	64	label	label	NOUN
cusj-5588	779	65	trial	trial	NOUN
cusj-5588	779	66	,	,	PUNCT
cusj-5588	779	67	tuszynski	tuszynski	NOUN
cusj-5588	779	68	,	,	PUNCT
cusj-5588	779	69	2007	2007	NUM
cusj-5588	779	70	)	)	PUNCT
cusj-5588	779	71	·	·	PUNCT
cusj-5588	780	1	development	development	NOUN
cusj-5588	780	2	of	of	ADP
cusj-5588	780	3	encapsulated	encapsulate	VERB
cusj-5588	780	4	cell	cell	NOUN
cusj-5588	780	5	biodelivery	biodelivery	NOUN
cusj-5588	780	6	implants	implant	NOUN
cusj-5588	780	7	to	to	PART
cusj-5588	780	8	increase	increase	VERB
cusj-5588	780	9	ngf	ngf	ADV
cusj-5588	780	10	release	release	NOUN
cusj-5588	780	11	(	(	PUNCT
cusj-5588	780	12	nsgene	nsgene	NOUN
cusj-5588	780	13	)	)	PUNCT
cusj-5588	780	14	·	·	PUNCT
cusj-5588	781	1	no	no	DET
cusj-5588	781	2	current	current	ADJ
cusj-5588	781	3	clinical	clinical	ADJ
cusj-5588	781	4	trials	trial	NOUN
cusj-5588	781	5	testing	test	VERB
cusj-5588	781	6	sctransplants	sctransplant	NOUN
cusj-5588	781	7	in	in	ADP
cusj-5588	781	8	ad	ad	NOUN
cusj-5588	781	9	parkinson	parkinson	NOUN
cusj-5588	781	10	’s	’s	PART
cusj-5588	781	11	disease	disease	NOUN
cusj-5588	781	12	·	·	PUNCT
cusj-5588	781	13	escs	esc	NOUN
cusj-5588	781	14	·	·	PUNCT
cusj-5588	781	15	restore	restore	VERB
cusj-5588	781	16	nigrostriatal	nigrostriatal	ADJ
cusj-5588	781	17	dopaminergic	dopaminergic	ADJ
cusj-5588	781	18	neuronal	neuronal	ADJ
cusj-5588	781	19	loss	loss	NOUN
cusj-5588	781	20	·	·	PUNCT
cusj-5588	781	21	successful	successful	ADJ
cusj-5588	781	22	clinical	clinical	ADJ
cusj-5588	781	23	open	open	ADJ
cusj-5588	781	24	-	-	PUNCT
cusj-5588	781	25	label	label	NOUN
cusj-5588	781	26	hfvm	hfvm	NOUN
cusj-5588	781	27	transplants	transplant	NOUN
cusj-5588	781	28	(	(	PUNCT
cusj-5588	781	29	lindvall	lindvall	ADV
cusj-5588	781	30	et	et	PROPN
cusj-5588	781	31	al	al	PROPN
cusj-5588	781	32	.	.	PROPN
cusj-5588	781	33	,	,	PUNCT
cusj-5588	781	34	1990	1990	NUM
cusj-5588	781	35	;	;	PUNCT
cusj-5588	781	36	madrazo	madrazo	PROPN
cusj-5588	781	37	et	et	PROPN
cusj-5588	781	38	al	al	PROPN
cusj-5588	781	39	.	.	PROPN
cusj-5588	781	40	,	,	PUNCT
cusj-5588	781	41	1988	1988	NUM
cusj-5588	781	42	)	)	PUNCT
cusj-5588	781	43	—	—	PUNCT
cusj-5588	781	44	provided	provide	VERB
cusj-5588	781	45	long	long	ADJ
cusj-5588	781	46	-	-	PUNCT
cusj-5588	781	47	term	term	NOUN
cusj-5588	781	48	symptomatic	symptomatic	ADJ
cusj-5588	781	49	relief	relief	NOUN
cusj-5588	781	50	,	,	PUNCT
cusj-5588	781	51	but	but	CCONJ
cusj-5588	781	52	failed	fail	VERB
cusj-5588	781	53	to	to	PART
cusj-5588	781	54	replicate	replicate	VERB
cusj-5588	781	55	in	in	ADP
cusj-5588	781	56	subsequent	subsequent	ADJ
cusj-5588	781	57	double	double	ADJ
cusj-5588	781	58	-	-	PUNCT
cusj-5588	781	59	blind	blind	ADJ
cusj-5588	781	60	trials	trial	NOUN
cusj-5588	781	61	(	(	PUNCT
cusj-5588	781	62	which	which	DET
cusj-5588	781	63	observed	observe	VERB
cusj-5588	781	64	gids	gid	NOUN
cusj-5588	781	65	)	)	PUNCT
cusj-5588	781	66	·	·	PUNCT
cusj-5588	781	67	successful	successful	ADJ
cusj-5588	781	68	animal	animal	NOUN
cusj-5588	781	69	studies	study	NOUN
cusj-5588	781	70	using	use	VERB
cusj-5588	781	71	escs	esc	NOUN
cusj-5588	781	72	&	&	CCONJ
cusj-5588	781	73	ipscs	ipscs	PROPN
cusj-5588	781	74	to	to	PART
cusj-5588	781	75	derive	derive	VERB
cusj-5588	781	76	da	da	ADJ
cusj-5588	781	77	phenotype	phenotype	NOUN
cusj-5588	781	78	,	,	PUNCT
cusj-5588	781	79	not	not	PART
cusj-5588	781	80	yet	yet	ADV
cusj-5588	781	81	translated	translate	VERB
cusj-5588	781	82	to	to	ADP
cusj-5588	781	83	clinical	clinical	ADJ
cusj-5588	781	84	trials	trial	NOUN
cusj-5588	781	85	due	due	ADP
cusj-5588	781	86	to	to	ADP
cusj-5588	781	87	risk	risk	NOUN
cusj-5588	781	88	of	of	ADP
cusj-5588	781	89	tumour	tumour	ADJ
cusj-5588	781	90	formation	formation	NOUN
cusj-5588	781	91	and	and	CCONJ
cusj-5588	781	92	technical	technical	ADJ
cusj-5588	781	93	difficulties	difficulty	NOUN
cusj-5588	781	94	huntington	huntington	PROPN
cusj-5588	781	95	’s	’s	PART
cusj-5588	781	96	disease	disease	NOUN
cusj-5588	781	97	·	·	PUNCT
cusj-5588	781	98	msns	msns	PROPN
cusj-5588	781	99	·	·	PUNCT
cusj-5588	781	100	restore	restore	VERB
cusj-5588	781	101	medium	medium	ADJ
cusj-5588	781	102	spiny	spiny	ADJ
cusj-5588	781	103	neuron	neuron	NOUN
cusj-5588	781	104	loss	loss	NOUN
cusj-5588	781	105	·	·	PUNCT
cusj-5588	781	106	successful	successful	ADJ
cusj-5588	781	107	clinical	clinical	ADJ
cusj-5588	781	108	fetal	fetal	ADJ
cusj-5588	781	109	striatal	striatal	ADJ
cusj-5588	781	110	grafting	grafting	NOUN
cusj-5588	781	111	(	(	PUNCT
cusj-5588	781	112	bachoud	bachoud	NOUN
cusj-5588	781	113	-	-	PUNCT
cusj-5588	781	114	lévi	lévi	NOUN
cusj-5588	781	115	et	et	PROPN
cusj-5588	781	116	al	al	PROPN
cusj-5588	781	117	.	.	PROPN
cusj-5588	781	118	,	,	PUNCT
cusj-5588	781	119	2000	2000	NUM
cusj-5588	781	120	)	)	PUNCT
cusj-5588	781	121	—	—	PUNCT
cusj-5588	781	122	provided	provide	VERB
cusj-5588	781	123	transient	transient	ADJ
cusj-5588	781	124	symptom	symptom	NOUN
cusj-5588	781	125	improvements	improvement	NOUN
cusj-5588	781	126	,	,	PUNCT
cusj-5588	781	127	but	but	CCONJ
cusj-5588	781	128	limited	limit	VERB
cusj-5588	781	129	by	by	ADP
cusj-5588	781	130	ethical	ethical	ADJ
cusj-5588	781	131	constraints	constraint	NOUN
cusj-5588	781	132	&	&	CCONJ
cusj-5588	781	133	poorly	poorly	ADV
cusj-5588	781	134	-	-	PUNCT
cusj-5588	781	135	understood	understand	VERB
cusj-5588	781	136	mechanism	mechanism	NOUN
cusj-5588	781	137	of	of	ADP
cusj-5588	781	138	action	action	NOUN
cusj-5588	781	139	·	·	PUNCT
cusj-5588	781	140	successful	successful	ADJ
cusj-5588	781	141	animal	animal	NOUN
cusj-5588	781	142	studies	study	NOUN
cusj-5588	781	143	using	use	VERB
cusj-5588	781	144	escs	esc	NOUN
cusj-5588	781	145	&	&	CCONJ
cusj-5588	781	146	ipscs	ipscs	NOUN
cusj-5588	781	147	to	to	PART
cusj-5588	781	148	restore	restore	VERB
cusj-5588	781	149	msn	msn	NOUN
cusj-5588	781	150	loss	loss	NOUN
cusj-5588	781	151	,	,	PUNCT
cusj-5588	781	152	not	not	PART
cusj-5588	781	153	yet	yet	ADV
cusj-5588	781	154	translated	translate	VERB
cusj-5588	781	155	to	to	ADP
cusj-5588	781	156	clinical	clinical	ADJ
cusj-5588	781	157	trials	trial	NOUN
cusj-5588	781	158	17	17	NUM
cusj-5588	781	159	cusj	cusj	NOUN
cusj-5588	781	160	2018	2018	NUM
cusj-5588	781	161	_	_	PUNCT
cusj-5588	782	1	_	_	PUNCT
cusj-5588	783	1	_	_	PUNCT
cusj-5588	784	1	_	_	PUNCT
cusj-5588	785	1	_	_	PUNCT
cusj-5588	786	1	_	_	PUNCT
cusj-5588	787	1	_	_	PUNCT
cusj-5588	788	1	_	_	PUNCT
cusj-5588	789	1	_	_	PUNCT
cusj-5588	790	1	_	_	PUNCT
cusj-5588	791	1	_	_	PUNCT
cusj-5588	792	1	_	_	PUNCT
cusj-5588	793	1	_	_	PUNCT
cusj-5588	794	1	_	_	PUNCT
cusj-5588	795	1	_	_	PUNCT
cusj-5588	796	1	_	_	PUNCT
cusj-5588	797	1	_	_	PUNCT
cusj-5588	798	1	_	_	PUNCT
cusj-5588	799	1	_	_	PUNCT
cusj-5588	800	1	_	_	PUNCT
cusj-5588	801	1	_	_	PUNCT
cusj-5588	802	1	_	_	PUNCT
cusj-5588	803	1	_	_	PUNCT
cusj-5588	804	1	_	_	PUNCT
cusj-5588	805	1	_	_	PUNCT
cusj-5588	806	1	_	_	PUNCT
cusj-5588	807	1	_	_	PUNCT
cusj-5588	808	1	_	_	PUNCT
cusj-5588	809	1	_	_	PUNCT
cusj-5588	810	1	_	_	PUNCT
cusj-5588	811	1	_	_	PUNCT
cusj-5588	812	1	_	_	PUNCT
cusj-5588	813	1	_	_	PUNCT
cusj-5588	814	1	_	_	PUNCT
cusj-5588	815	1	_	_	PUNCT
cusj-5588	816	1	_	_	PUNCT
cusj-5588	817	1	_	_	PUNCT
cusj-5588	818	1	_	_	PUNCT
cusj-5588	819	1	_	_	PUNCT
cusj-5588	820	1	_	_	PUNCT
cusj-5588	821	1	_	_	PUNCT
cusj-5588	822	1	_	_	PUNCT
cusj-5588	823	1	_	_	PUNCT
cusj-5588	824	1	_	_	PUNCT
cusj-5588	825	1	_	_	PUNCT
cusj-5588	826	1	_	_	PUNCT
cusj-5588	827	1	_	_	PUNCT
cusj-5588	828	1	_	_	PUNCT
cusj-5588	829	1	_	_	PUNCT
cusj-5588	830	1	_	_	PUNCT
cusj-5588	831	1	_	_	PUNCT
cusj-5588	832	1	_	_	PUNCT
cusj-5588	833	1	_	_	PUNCT
cusj-5588	834	1	_	_	PUNCT
cusj-5588	835	1	_	_	PUNCT
cusj-5588	836	1	_	_	PUNCT
cusj-5588	837	1	_	_	PUNCT
cusj-5588	838	1	_	_	PUNCT
cusj-5588	839	1	_	_	PUNCT
cusj-5588	840	1	_	_	PUNCT
cusj-5588	841	1	_	_	PUNCT
cusj-5588	842	1	_	_	PUNCT
cusj-5588	843	1	_	_	PUNCT
cusj-5588	844	1	_	_	PUNCT
cusj-5588	845	1	_	_	PUNCT
cusj-5588	846	1	_	_	PUNCT
cusj-5588	847	1	_	_	PUNCT
cusj-5588	848	1	_	_	PUNCT
cusj-5588	849	1	_	_	PUNCT
cusj-5588	850	1	_	_	PUNCT
cusj-5588	851	1	_	_	PUNCT
cusj-5588	852	1	_	_	PUNCT
cusj-5588	853	1	_	_	PUNCT
cusj-5588	854	1	_	_	PUNCT
cusj-5588	855	1	_	_	PUNCT
cusj-5588	856	1	_	_	PUNCT
cusj-5588	857	1	_	_	PUNCT
cusj-5588	858	1	_	_	PUNCT
cusj-5588	859	1	_	_	PUNCT
cusj-5588	860	1	_	_	PUNCT
cusj-5588	860	2	works	work	NOUN
cusj-5588	860	3	cited	cite	VERB
cusj-5588	860	4	[	[	X
cusj-5588	860	5	1	1	X
cusj-5588	860	6	]	]	PUNCT
cusj-5588	860	7	azzouz	azzouz	NOUN
cusj-5588	860	8	m.	m.	NOUN
cusj-5588	860	9	,	,	PUNCT
cusj-5588	860	10	martin	martin	PROPN
cusj-5588	860	11	-	-	PUNCT
cusj-5588	860	12	rendon	rendon	PROPN
cusj-5588	860	13	e.	e.	PROPN
cusj-5588	860	14	,	,	PUNCT
cusj-5588	860	15	barber	barber	PROPN
cusj-5588	860	16	r.d	r.d	PROPN
cusj-5588	860	17	.	.	PROPN
cusj-5588	860	18	,	,	PUNCT
cusj-5588	860	19	mitrophanous	mitrophanous	ADJ
cusj-5588	860	20	k.a	k.a	PROPN
cusj-5588	860	21	.	.	PROPN
cusj-5588	860	22	,	,	PUNCT
cusj-5588	860	23	carter	carter	PROPN
cusj-5588	860	24	e.e	e.e	PROPN
cusj-5588	860	25	.	.	PROPN
cusj-5588	860	26	,	,	PUNCT
cusj-5588	860	27	rohll	rohll	VERB
cusj-5588	860	28	j.b	j.b	PROPN
cusj-5588	860	29	.	.	PROPN
cusj-5588	860	30	,	,	PUNCT
cusj-5588	860	31	kingsman	kingsman	PROPN
cusj-5588	860	32	s.m	s.m	PROPN
cusj-5588	860	33	.	.	PROPN
cusj-5588	861	1	(	(	PUNCT
cusj-5588	861	2	2002	2002	NUM
cusj-5588	861	3	)	)	PUNCT
cusj-5588	861	4	.	.	PUNCT
cusj-5588	862	1	multicistronic	multicistronic	PROPN
cusj-5588	862	2	lentiviral	lentiviral	ADJ
cusj-5588	862	3	vector	vector	PROPN
cusj-5588	862	4	-	-	PUNCT
cusj-5588	862	5	mediated	mediate	VERB
cusj-5588	862	6	striatal	striatal	ADJ
cusj-5588	862	7	gene	gene	NOUN
cusj-5588	862	8	transfer	transfer	NOUN
cusj-5588	862	9	of	of	ADP
cusj-5588	862	10	aromatic	aromatic	ADJ
cusj-5588	862	11	l	l	NOUN
cusj-5588	862	12	-	-	ADJ
cusj-5588	862	13	amino	amino	ADJ
cusj-5588	862	14	acid	acid	NOUN
cusj-5588	862	15	decarboxylase	decarboxylase	NOUN
cusj-5588	862	16	,	,	PUNCT
cusj-5588	862	17	tyrosine	tyrosine	NOUN
cusj-5588	862	18	hydroxylase	hydroxylase	NOUN
cusj-5588	862	19	,	,	PUNCT
cusj-5588	862	20	and	and	CCONJ
cusj-5588	862	21	gtp	gtp	NOUN
cusj-5588	862	22	cyclohydrolase	cyclohydrolase	NOUN
cusj-5588	863	1	i	i	PRON
cusj-5588	863	2	induces	induce	VERB
cusj-5588	863	3	sustained	sustained	ADJ
cusj-5588	863	4	transgene	transgene	ADJ
cusj-5588	863	5	expression	expression	NOUN
cusj-5588	863	6	,	,	PUNCT
cusj-5588	863	7	dopamine	dopamine	NOUN
cusj-5588	863	8	production	production	NOUN
cusj-5588	863	9	,	,	PUNCT
cusj-5588	863	10	and	and	CCONJ
cusj-5588	863	11	functional	functional	ADJ
cusj-5588	863	12	improvement	improvement	NOUN
cusj-5588	863	13	in	in	ADP
cusj-5588	863	14	a	a	DET
cusj-5588	863	15	rat	rat	NOUN
cusj-5588	863	16	model	model	NOUN
cusj-5588	863	17	of	of	ADP
cusj-5588	863	18	parkinson	parkinson	NOUN
cusj-5588	863	19	's	's	PART
cusj-5588	863	20	disease	disease	NOUN
cusj-5588	863	21	.	.	PUNCT
cusj-5588	864	1	j.	j.	PROPN
cusj-5588	864	2	neurosci	neurosci	PROPN
cusj-5588	864	3	.	.	PROPN
cusj-5588	864	4	,	,	PUNCT
cusj-5588	864	5	22	22	NUM
cusj-5588	864	6	(	(	PUNCT
cusj-5588	864	7	23	23	NUM
cusj-5588	864	8	)	)	PUNCT
cusj-5588	864	9	,	,	PUNCT
cusj-5588	864	10	10302–10312	10302–10312	NUM
cusj-5588	864	11	.	.	PUNCT
cusj-5588	865	1	[	[	X
cusj-5588	865	2	2	2	NUM
cusj-5588	865	3	]	]	PUNCT
cusj-5588	865	4	bachoud	bachoud	ADJ
cusj-5588	865	5	-	-	PUNCT
cusj-5588	865	6	lévi	lévi	ADJ
cusj-5588	865	7	a	a	PROPN
cusj-5588	865	8	-	-	PUNCT
cusj-5588	865	9	c	c	NOUN
cusj-5588	865	10	,	,	PUNCT
cusj-5588	865	11	rémy	rémy	NOUN
cusj-5588	865	12	p	p	PRON
cusj-5588	865	13	,	,	PUNCT
cusj-5588	865	14	nǵuyen	nǵuyen	PROPN
cusj-5588	865	15	j	j	PROPN
cusj-5588	865	16	-	-	PUNCT
cusj-5588	865	17	p	p	PROPN
cusj-5588	865	18	,	,	PUNCT
cusj-5588	865	19	brugières	brugière	VERB
cusj-5588	865	20	p	p	PRON
cusj-5588	865	21	,	,	PUNCT
cusj-5588	865	22	lefaucheur	lefaucheur	PROPN
cusj-5588	865	23	j	j	PROPN
cusj-5588	865	24	-	-	PROPN
cusj-5588	865	25	p	p	PROPN
cusj-5588	865	26	,	,	PUNCT
cusj-5588	865	27	bourdet	bourdet	NOUN
cusj-5588	865	28	c	c	PROPN
cusj-5588	865	29	,	,	PUNCT
cusj-5588	865	30	baudic	baudic	PROPN
cusj-5588	865	31	s	s	SYM
cusj-5588	865	32	,	,	PUNCT
cusj-5588	865	33	gaura	gaura	NOUN
cusj-5588	865	34	v	v	ADP
cusj-5588	865	35	et	et	NOUN
cusj-5588	865	36	al	al	PROPN
cusj-5588	865	37	(	(	PUNCT
cusj-5588	865	38	2000	2000	NUM
cusj-5588	865	39	)	)	PUNCT
cusj-5588	865	40	motor	motor	NOUN
cusj-5588	865	41	and	and	CCONJ
cusj-5588	865	42	cognitive	cognitive	ADJ
cusj-5588	865	43	improvements	improvement	NOUN
cusj-5588	865	44	in	in	ADP
cusj-5588	865	45	patients	patient	NOUN
cusj-5588	865	46	with	with	ADP
cusj-5588	865	47	huntington	huntington	PROPN
cusj-5588	865	48	’s	’s	PART
cusj-5588	865	49	disease	disease	NOUN
cusj-5588	865	50	after	after	ADP
cusj-5588	865	51	neural	neural	ADJ
cusj-5588	865	52	transplantation	transplantation	NOUN
cusj-5588	865	53	.	.	PUNCT
cusj-5588	866	1	lancet	lancet	NOUN
cusj-5588	866	2	356(9246):1975–1979	356(9246):1975–1979	NUM
cusj-5588	867	1	[	[	X
cusj-5588	867	2	3	3	NUM
cusj-5588	867	3	]	]	X
cusj-5588	867	4	bartus	bartus	NOUN
cusj-5588	867	5	,	,	PUNCT
cusj-5588	867	6	r.t	r.t	PROPN
cusj-5588	867	7	.	.	PROPN
cusj-5588	867	8	,	,	PUNCT
cusj-5588	867	9	brown	brown	PROPN
cusj-5588	867	10	l.	l.	PROPN
cusj-5588	867	11	,	,	PUNCT
cusj-5588	867	12	wilson	wilson	PROPN
cusj-5588	867	13	,	,	PUNCT
cusj-5588	867	14	a.	a.	PROPN
cusj-5588	867	15	,	,	PUNCT
cusj-5588	867	16	kruegel	kruegel	PROPN
cusj-5588	867	17	,	,	PUNCT
cusj-5588	867	18	b.	b.	PROPN
cusj-5588	867	19	,	,	PUNCT
cusj-5588	867	20	siffert	siffert	PROPN
cusj-5588	867	21	,	,	PUNCT
cusj-5588	867	22	j.	j.	PROPN
cusj-5588	867	23	properly	properly	ADV
cusj-5588	867	24	scaled	scale	VERB
cusj-5588	867	25	and	and	CCONJ
cusj-5588	867	26	targeted	target	VERB
cusj-5588	867	27	aav2	aav2	PROPN
cusj-5588	867	28	-	-	PUNCT
cusj-5588	867	29	nrtn	nrtn	PROPN
cusj-5588	867	30	(	(	PUNCT
cusj-5588	867	31	neurturin	neurturin	NOUN
cusj-5588	867	32	)	)	PUNCT
cusj-5588	867	33	to	to	ADP
cusj-5588	867	34	the	the	DET
cusj-5588	867	35	substantia	substantia	NOUN
cusj-5588	867	36	nigra	nigra	NOUN
cusj-5588	867	37	is	be	AUX
cusj-5588	867	38	safe	safe	ADJ
cusj-5588	867	39	,	,	PUNCT
cusj-5588	867	40	effective	effective	ADJ
cusj-5588	867	41	and	and	CCONJ
cusj-5588	867	42	causes	cause	VERB
cusj-5588	867	43	no	no	DET
cusj-5588	867	44	weight	weight	NOUN
cusj-5588	867	45	loss	loss	NOUN
cusj-5588	867	46	:	:	PUNCT
cusj-5588	867	47	support	support	NOUN
cusj-5588	867	48	for	for	ADP
cusj-5588	867	49	nigral	nigral	ADJ
cusj-5588	867	50	targeting	target	VERB
cusj-5588	867	51	in	in	ADP
cusj-5588	867	52	parkinson	parkinson	NOUN
cusj-5588	867	53	's	's	PART
cusj-5588	867	54	disease	disease	NOUN
cusj-5588	867	55	.	.	PUNCT
cusj-5588	868	1	neurobiol	neurobiol	PROPN
cusj-5588	868	2	.	.	PUNCT
cusj-5588	869	1	dis	dis	PROPN
cusj-5588	869	2	.	.	PROPN
cusj-5588	869	3	,	,	PUNCT
cusj-5588	869	4	44	44	NUM
cusj-5588	869	5	(	(	PUNCT
cusj-5588	869	6	2011	2011	NUM
cusj-5588	869	7	)	)	PUNCT
cusj-5588	869	8	,	,	PUNCT
cusj-5588	869	9	38–52	38–52	NUM
cusj-5588	869	10	.	.	PUNCT
cusj-5588	870	1	[	[	X
cusj-5588	870	2	4	4	NUM
cusj-5588	870	3	]	]	X
cusj-5588	870	4	blurton	blurton	NOUN
cusj-5588	870	5	-	-	PUNCT
cusj-5588	870	6	jones	jones	PROPN
cusj-5588	870	7	,	,	PUNCT
cusj-5588	870	8	m.	m.	NOUN
cusj-5588	870	9	,	,	PUNCT
cusj-5588	870	10	kitazawa	kitazawa	PROPN
cusj-5588	870	11	,	,	PUNCT
cusj-5588	870	12	m.	m.	NOUN
cusj-5588	870	13	,	,	PUNCT
cusj-5588	870	14	martinez	martinez	PROPN
cusj-5588	870	15	-	-	PUNCT
cusj-5588	870	16	coria	coria	PROPN
cusj-5588	870	17	,	,	PUNCT
cusj-5588	870	18	h.	h.	PROPN
cusj-5588	870	19	,	,	PUNCT
cusj-5588	870	20	castello	castello	PROPN
cusj-5588	870	21	,	,	PUNCT
cusj-5588	870	22	n.	n.	PROPN
cusj-5588	870	23	a.	a.	PROPN
cusj-5588	870	24	,	,	PUNCT
cusj-5588	870	25	müller	müller	PROPN
cusj-5588	870	26	,	,	PUNCT
cusj-5588	870	27	f.j	f.j	PROPN
cusj-5588	870	28	.	.	PROPN
cusj-5588	870	29	,	,	PUNCT
cusj-5588	870	30	loring	loring	PROPN
cusj-5588	870	31	,	,	PUNCT
cusj-5588	870	32	j.	j.	PROPN
cusj-5588	870	33	f.	f.	PROPN
cusj-5588	870	34	,	,	PUNCT
cusj-5588	870	35	et	et	PROPN
cusj-5588	870	36	al	al	PROPN
cusj-5588	870	37	.	.	PUNCT
cusj-5588	871	1	(	(	PUNCT
cusj-5588	871	2	2009	2009	NUM
cusj-5588	871	3	)	)	PUNCT
cusj-5588	871	4	.	.	PUNCT
cusj-5588	872	1	neural	neural	ADJ
cusj-5588	872	2	stem	stem	NOUN
cusj-5588	872	3	cells	cell	NOUN
cusj-5588	872	4	improve	improve	VERB
cusj-5588	872	5	cognition	cognition	NOUN
cusj-5588	872	6	via	via	ADP
cusj-5588	872	7	bdnf	bdnf	PROPN
cusj-5588	872	8	in	in	ADP
cusj-5588	872	9	a	a	DET
cusj-5588	872	10	transgenic	transgenic	NOUN
cusj-5588	872	11	model	model	NOUN
cusj-5588	872	12	of	of	ADP
cusj-5588	872	13	alzheimer	alzheimer	PROPN
cusj-5588	872	14	disease	disease	PROPN
cusj-5588	872	15	.	.	PUNCT
cusj-5588	873	1	proc	proc	PROPN
cusj-5588	873	2	.	.	PUNCT
cusj-5588	874	1	natl	natl	PROPN
cusj-5588	874	2	.	.	PUNCT
cusj-5588	875	1	acad	acad	PROPN
cusj-5588	875	2	.	.	PUNCT
cusj-5588	876	1	sci	sci	PROPN
cusj-5588	876	2	.	.	PUNCT
cusj-5588	876	3	u.s.a	u.s.a	PROPN
cusj-5588	876	4	.	.	PROPN
cusj-5588	876	5	106	106	NUM
cusj-5588	876	6	,	,	PUNCT
cusj-5588	876	7	13594–13599	13594–13599	NUM
cusj-5588	876	8	.	.	PUNCT
cusj-5588	877	1	[	[	X
cusj-5588	877	2	5	5	NUM
cusj-5588	877	3	]	]	X
cusj-5588	877	4	brundin	brundin	VERB
cusj-5588	877	5	,	,	PUNCT
cusj-5588	877	6	p.	p.	PROPN
cusj-5588	877	7	,	,	PUNCT
cusj-5588	877	8	barker	barker	PROPN
cusj-5588	877	9	,	,	PUNCT
cusj-5588	877	10	r.	r.	PROPN
cusj-5588	877	11	,	,	PUNCT
cusj-5588	877	12	parmar	parmar	PROPN
cusj-5588	877	13	,	,	PUNCT
cusj-5588	877	14	m.	m.	NOUN
cusj-5588	877	15	(	(	PUNCT
cusj-5588	877	16	2010	2010	NUM
cusj-5588	877	17	)	)	PUNCT
cusj-5588	877	18	.	.	PUNCT
cusj-5588	878	1	neural	neural	ADJ
cusj-5588	878	2	grafting	grafting	NOUN
cusj-5588	878	3	in	in	ADP
cusj-5588	878	4	parkinson	parkinson	NOUN
cusj-5588	878	5	’s	’s	PART
cusj-5588	878	6	disease	disease	NOUN
cusj-5588	878	7	:	:	PUNCT
cusj-5588	878	8	problems	problem	NOUN
cusj-5588	878	9	and	and	CCONJ
cusj-5588	878	10	possibilities	possibility	NOUN
cusj-5588	878	11	.	.	PUNCT
cusj-5588	879	1	progress	progress	NOUN
cusj-5588	879	2	in	in	ADP
cusj-5588	879	3	brain	brain	NOUN
cusj-5588	879	4	research	research	NOUN
cusj-5588	879	5	,	,	PUNCT
cusj-5588	879	6	vol	vol	NOUN
cusj-5588	879	7	.	.	PROPN
cusj-5588	880	1	184	184	NUM
cusj-5588	880	2	,	,	PUNCT
cusj-5588	880	3	chapter	chapter	NOUN
cusj-5588	880	4	14	14	NUM
cusj-5588	880	5	.	.	PUNCT
cusj-5588	881	1	[	[	X
cusj-5588	881	2	6	6	NUM
cusj-5588	881	3	]	]	SYM
cusj-5588	881	4	busse	busse	NOUN
cusj-5588	881	5	,	,	PUNCT
cusj-5588	881	6	m.	m.	NOUN
cusj-5588	881	7	,	,	PUNCT
cusj-5588	881	8	khalil	khalil	PROPN
cusj-5588	881	9	,	,	PUNCT
cusj-5588	881	10	h.	h.	PROPN
cusj-5588	881	11	,	,	PUNCT
cusj-5588	881	12	brooks	brooks	PROPN
cusj-5588	881	13	,	,	PUNCT
cusj-5588	881	14	s.	s.	PROPN
cusj-5588	881	15	,	,	PUNCT
cusj-5588	881	16	quinn	quinn	PROPN
cusj-5588	881	17	,	,	PUNCT
cusj-5588	881	18	l.	l.	PROPN
cusj-5588	881	19	,	,	PUNCT
cusj-5588	881	20	rosser	rosser	PROPN
cusj-5588	881	21	,	,	PUNCT
cusj-5588	881	22	a.	a.	NOUN
cusj-5588	881	23	(	(	PUNCT
cusj-5588	881	24	2012	2012	NUM
cusj-5588	881	25	)	)	PUNCT
cusj-5588	881	26	.	.	PUNCT
cusj-5588	882	1	practice	practice	NOUN
cusj-5588	882	2	,	,	PUNCT
cusj-5588	882	3	progress	progress	NOUN
cusj-5588	882	4	and	and	CCONJ
cusj-5588	882	5	future	future	ADJ
cusj-5588	882	6	directions	direction	NOUN
cusj-5588	882	7	for	for	ADP
cusj-5588	882	8	physical	physical	ADJ
cusj-5588	882	9	therapies	therapy	NOUN
cusj-5588	882	10	in	in	ADP
cusj-5588	882	11	huntington	huntington	PROPN
cusj-5588	882	12	’s	’s	PART
cusj-5588	882	13	disease	disease	NOUN
cusj-5588	882	14	.	.	PUNCT
cusj-5588	883	1	journal	journal	PROPN
cusj-5588	883	2	of	of	ADP
cusj-5588	883	3	huntington	huntington	PROPN
cusj-5588	883	4	’s	’s	PART
cusj-5588	883	5	disease	disease	NOUN
cusj-5588	883	6	.	.	PUNCT
cusj-5588	884	1	1(2	1(2	NUM
cusj-5588	884	2	)	)	PUNCT
cusj-5588	884	3	,	,	PUNCT
cusj-5588	884	4	175	175	NUM
cusj-5588	884	5	-	-	SYM
cusj-5588	884	6	85	85	NUM
cusj-5588	884	7	.	.	PUNCT
cusj-5588	885	1	[	[	X
cusj-5588	885	2	7	7	NUM
cusj-5588	885	3	]	]	X
cusj-5588	885	4	carroll	carroll	PROPN
cusj-5588	885	5	,	,	PUNCT
cusj-5588	885	6	j.	j.	PROPN
cusj-5588	885	7	b.	b.	PROPN
cusj-5588	885	8	,	,	PUNCT
cusj-5588	885	9	warby	warby	PROPN
cusj-5588	885	10	,	,	PUNCT
cusj-5588	885	11	s.	s.	PROPN
cusj-5588	885	12	c.	c.	PROPN
cusj-5588	885	13	,	,	PUNCT
cusj-5588	885	14	southwell	southwell	PROPN
cusj-5588	885	15	,	,	PUNCT
cusj-5588	885	16	a.	a.	PROPN
cusj-5588	885	17	l.	l.	PROPN
cusj-5588	885	18	,	,	PUNCT
cusj-5588	885	19	doty	doty	PROPN
cusj-5588	885	20	,	,	PUNCT
cusj-5588	885	21	c.	c.	PROPN
cusj-5588	885	22	n.	n.	PROPN
cusj-5588	885	23	,	,	PUNCT
cusj-5588	885	24	greenlee	greenlee	PROPN
cusj-5588	885	25	,	,	PUNCT
cusj-5588	885	26	s.	s.	PROPN
cusj-5588	885	27	,	,	PUNCT
cusj-5588	885	28	skotte	skotte	NOUN
cusj-5588	885	29	,	,	PUNCT
cusj-5588	885	30	n.	n.	NOUN
cusj-5588	885	31	,	,	PUNCT
cusj-5588	885	32	et	et	PROPN
cusj-5588	885	33	al	al	PROPN
cusj-5588	885	34	.	.	PUNCT
cusj-5588	885	35	(	(	PUNCT
cusj-5588	885	36	2011	2011	NUM
cusj-5588	885	37	)	)	PUNCT
cusj-5588	885	38	.	.	PUNCT
cusj-5588	886	1	potent	potent	ADJ
cusj-5588	886	2	and	and	CCONJ
cusj-5588	886	3	selective	selective	ADJ
cusj-5588	886	4	antisense	antisense	NOUN
cusj-5588	886	5	oligonucleotides	oligonucleotide	NOUN
cusj-5588	886	6	targeting	target	VERB
cusj-5588	886	7	single	single	ADJ
cusj-5588	886	8	-	-	PUNCT
cusj-5588	886	9	nucleotide	nucleotide	NOUN
cusj-5588	886	10	polymorphisms	polymorphism	NOUN
cusj-5588	886	11	in	in	ADP
cusj-5588	886	12	the	the	DET
cusj-5588	886	13	huntington	huntington	PROPN
cusj-5588	886	14	disease	disease	PROPN
cusj-5588	886	15	gene	gene	NOUN
cusj-5588	886	16	/	/	SYM
cusj-5588	886	17	allele	allele	NOUN
cusj-5588	886	18	specific	specific	ADJ
cusj-5588	886	19	silencing	silencing	NOUN
cusj-5588	886	20	of	of	ADP
cusj-5588	886	21	mutant	mutant	ADJ
cusj-5588	886	22	huntingtin	huntingtin	NOUN
cusj-5588	886	23	.	.	PUNCT
cusj-5588	887	1	mol	mol	PROPN
cusj-5588	887	2	.	.	PROPN
cusj-5588	888	1	ther	ther	PROPN
cusj-5588	888	2	.	.	PUNCT
cusj-5588	889	1	19	19	NUM
cusj-5588	889	2	,	,	PUNCT
cusj-5588	889	3	2178	2178	NUM
cusj-5588	889	4	–	–	PUNCT
cusj-5588	889	5	2185	2185	NUM
cusj-5588	889	6	.	.	PUNCT
cusj-5588	890	1	[	[	X
cusj-5588	890	2	8	8	NUM
cusj-5588	890	3	]	]	SYM
cusj-5588	890	4	chmielnicki	chmielnicki	NOUN
cusj-5588	890	5	,	,	PUNCT
cusj-5588	890	6	e.	e.	PROPN
cusj-5588	890	7	&	&	CCONJ
cusj-5588	890	8	goldman	goldman	PROPN
cusj-5588	890	9	,	,	PUNCT
cusj-5588	890	10	s.	s.	PROPN
cusj-5588	890	11	stem	stem	VERB
cusj-5588	890	12	cells	cell	NOUN
cusj-5588	890	13	and	and	CCONJ
cusj-5588	890	14	cell	cell	NOUN
cusj-5588	890	15	-	-	PUNCT
cusj-5588	890	16	based	base	VERB
cusj-5588	890	17	therapy	therapy	NOUN
cusj-5588	890	18	in	in	ADP
cusj-5588	890	19	neurodegenerative	neurodegenerative	ADJ
cusj-5588	890	20	disease	disease	NOUN
cusj-5588	890	21	.	.	PUNCT
cusj-5588	891	1	in	in	ADP
cusj-5588	891	2	beal	beal	NOUN
cusj-5588	891	3	,	,	PUNCT
cusj-5588	891	4	m.	m.	NOUN
cusj-5588	891	5	,	,	PUNCT
cusj-5588	891	6	lang	lang	PROPN
cusj-5588	891	7	,	,	PUNCT
cusj-5588	891	8	a.	a.	PROPN
cusj-5588	891	9	,	,	PUNCT
cusj-5588	891	10	ludolph	ludolph	VERB
cusj-5588	891	11	,	,	PUNCT
cusj-5588	891	12	a.	a.	NOUN
cusj-5588	891	13	(	(	PUNCT
cusj-5588	891	14	eds	eds	PROPN
cusj-5588	891	15	.	.	PUNCT
cusj-5588	891	16	)	)	PUNCT
cusj-5588	892	1	,	,	PUNCT
cusj-5588	892	2	neurodegenerative	neurodegenerative	ADJ
cusj-5588	892	3	diseases	disease	NOUN
cusj-5588	892	4	:	:	PUNCT
cusj-5588	892	5	neurobiology	neurobiology	NOUN
cusj-5588	892	6	,	,	PUNCT
cusj-5588	892	7	pathogenesis	pathogenesis	NOUN
cusj-5588	892	8	and	and	CCONJ
cusj-5588	892	9	therapeutics	therapeutic	NOUN
cusj-5588	892	10	(	(	PUNCT
cusj-5588	892	11	329	329	NUM
cusj-5588	892	12	-	-	SYM
cusj-5588	892	13	40	40	NUM
cusj-5588	892	14	)	)	PUNCT
cusj-5588	892	15	.	.	PUNCT
cusj-5588	893	1	cambridge	cambridge	PROPN
cusj-5588	893	2	university	university	PROPN
cusj-5588	893	3	press	press	NOUN
cusj-5588	893	4	.	.	PUNCT
cusj-5588	894	1	[	[	X
cusj-5588	894	2	9	9	NUM
cusj-5588	894	3	]	]	PUNCT
cusj-5588	894	4	cooper	cooper	NOUN
cusj-5588	894	5	o	o	PROPN
cusj-5588	894	6	,	,	PUNCT
cusj-5588	894	7	hargus	hargus	ADJ
cusj-5588	894	8	g	g	NOUN
cusj-5588	894	9	,	,	PUNCT
cusj-5588	894	10	deleidi	deleidi	VERB
cusj-5588	894	11	m	m	PROPN
cusj-5588	894	12	,	,	PUNCT
cusj-5588	894	13	et	et	PROPN
cusj-5588	894	14	al	al	PROPN
cusj-5588	894	15	.	.	PUNCT
cusj-5588	895	1	(	(	PUNCT
cusj-5588	895	2	2010	2010	NUM
cusj-5588	895	3	)	)	PUNCT
cusj-5588	895	4	.	.	PUNCT
cusj-5588	896	1	differentiation	differentiation	NOUN
cusj-5588	896	2	of	of	ADP
cusj-5588	896	3	human	human	ADJ
cusj-5588	896	4	es	es	NOUN
cusj-5588	896	5	and	and	CCONJ
cusj-5588	896	6	parkinson	parkinson	NOUN
cusj-5588	896	7	’s	’s	PART
cusj-5588	896	8	disease	disease	NOUN
cusj-5588	896	9	ips	ips	NOUN
cusj-5588	896	10	cells	cell	NOUN
cusj-5588	896	11	into	into	ADP
cusj-5588	896	12	ventral	ventral	ADJ
cusj-5588	896	13	midbrain	midbrain	NOUN
cusj-5588	896	14	dopaminergic	dopaminergic	ADJ
cusj-5588	896	15	neurons	neuron	NOUN
cusj-5588	896	16	requires	require	VERB
cusj-5588	896	17	a	a	DET
cusj-5588	896	18	high	high	ADJ
cusj-5588	896	19	activity	activity	NOUN
cusj-5588	896	20	form	form	NOUN
cusj-5588	896	21	of	of	ADP
cusj-5588	896	22	shh	shh	PROPN
cusj-5588	896	23	,	,	PUNCT
cusj-5588	896	24	fgf8a	fgf8a	PROPN
cusj-5588	896	25	and	and	CCONJ
cusj-5588	896	26	specific	specific	ADJ
cusj-5588	896	27	regionalization	regionalization	NOUN
cusj-5588	896	28	by	by	ADP
cusj-5588	896	29	retinoic	retinoic	PROPN
cusj-5588	896	30	acid	acid	PROPN
cusj-5588	896	31	.	.	PUNCT
cusj-5588	897	1	mol	mol	ADP
cusj-5588	897	2	cell	cell	NOUN
cusj-5588	897	3	neurosci	neurosci	NOUN
cusj-5588	897	4	.	.	PUNCT
cusj-5588	898	1	45:258	45:258	NUM
cusj-5588	898	2	–	–	PUNCT
cusj-5588	898	3	266	266	NUM
cusj-5588	898	4	.	.	PUNCT
cusj-5588	899	1	[	[	X
cusj-5588	899	2	10	10	NUM
cusj-5588	899	3	]	]	X
cusj-5588	899	4	desai	desai	PROPN
cusj-5588	899	5	,	,	PUNCT
cusj-5588	899	6	a.	a.	PROPN
cusj-5588	899	7	&	&	CCONJ
cusj-5588	899	8	gossberg	gossberg	PROPN
cusj-5588	899	9	,	,	PUNCT
cusj-5588	899	10	g.	g.	PROPN
cusj-5588	899	11	(	(	PUNCT
cusj-5588	899	12	2005	2005	NUM
cusj-5588	899	13	)	)	PUNCT
cusj-5588	899	14	.	.	PUNCT
cusj-5588	900	1	diagnosis	diagnosis	NOUN
cusj-5588	900	2	and	and	CCONJ
cusj-5588	900	3	treatment	treatment	NOUN
cusj-5588	900	4	of	of	ADP
cusj-5588	900	5	alzheimer	alzheimer	PROPN
cusj-5588	900	6	’s	’s	PART
cusj-5588	900	7	disease	disease	NOUN
cusj-5588	900	8	.	.	PUNCT
cusj-5588	901	1	neurology	neurology	NOUN
cusj-5588	901	2	.	.	PUNCT
cusj-5588	902	1	64(12	64(12	NUM
cusj-5588	902	2	)	)	PUNCT
cusj-5588	902	3	,	,	PUNCT
cusj-5588	902	4	s34	s34	NOUN
cusj-5588	902	5	-	-	PUNCT
cusj-5588	902	6	9	9	NUM
cusj-5588	902	7	.	.	PUNCT
cusj-5588	903	1	[	[	X
cusj-5588	903	2	11]ebert	11]ebert	NUM
cusj-5588	903	3	ad	ad	NOUN
cusj-5588	903	4	,	,	PUNCT
cusj-5588	903	5	barber	barber	PROPN
cusj-5588	903	6	ae	ae	PROPN
cusj-5588	903	7	,	,	PUNCT
cusj-5588	903	8	heins	heins	PROPN
cusj-5588	903	9	bm	bm	PROPN
cusj-5588	903	10	,	,	PUNCT
cusj-5588	903	11	svendsen	svendsen	PROPN
cusj-5588	903	12	cn	cn	PROPN
cusj-5588	903	13	.	.	PUNCT
cusj-5588	904	1	ex	ex	PRON
cusj-5588	904	2	vivo	vivo	ADJ
cusj-5588	904	3	delivery	delivery	NOUN
cusj-5588	904	4	of	of	ADP
cusj-5588	904	5	gdnf	gdnf	PROPN
cusj-5588	904	6	maintains	maintain	VERB
cusj-5588	904	7	motor	motor	NOUN
cusj-5588	904	8	function	function	NOUN
cusj-5588	904	9	and	and	CCONJ
cusj-5588	904	10	prevents	prevent	VERB
cusj-5588	904	11	neuronal	neuronal	ADJ
cusj-5588	904	12	loss	loss	NOUN
cusj-5588	904	13	in	in	ADP
cusj-5588	904	14	a	a	DET
cusj-5588	904	15	transgenic	transgenic	NOUN
cusj-5588	904	16	mouse	mouse	NOUN
cusj-5588	904	17	model	model	NOUN
cusj-5588	904	18	of	of	ADP
cusj-5588	904	19	huntington	huntington	PROPN
cusj-5588	904	20	’s	’s	PART
cusj-5588	904	21	disease	disease	NOUN
cusj-5588	904	22	.	.	PUNCT
cusj-5588	905	1	experimental	experimental	ADJ
cusj-5588	905	2	neurology	neurology	NOUN
cusj-5588	905	3	.	.	PUNCT
cusj-5588	906	1	2010	2010	NUM
cusj-5588	906	2	;	;	PUNCT
cusj-5588	906	3	224:155–162	224:155–162	NUM
cusj-5588	906	4	.	.	PUNCT
cusj-5588	907	1	[	[	X
cusj-5588	907	2	12	12	NUM
cusj-5588	907	3	]	]	X
cusj-5588	907	4	goldman	goldman	NOUN
cusj-5588	907	5	,	,	PUNCT
cusj-5588	907	6	s.	s.	PROPN
cusj-5588	907	7	(	(	PUNCT
cusj-5588	907	8	2005	2005	NUM
cusj-5588	907	9	)	)	PUNCT
cusj-5588	907	10	.	.	PUNCT
cusj-5588	908	1	stem	stem	NOUN
cusj-5588	908	2	and	and	CCONJ
cusj-5588	908	3	progenitor	progenitor	NOUN
cusj-5588	908	4	cell	cell	NOUN
cusj-5588	908	5	-	-	PUNCT
cusj-5588	908	6	based	base	VERB
cusj-5588	908	7	therapy	therapy	NOUN
cusj-5588	908	8	of	of	ADP
cusj-5588	908	9	the	the	DET
cusj-5588	908	10	human	human	ADJ
cusj-5588	908	11	central	central	ADJ
cusj-5588	908	12	nervous	nervous	ADJ
cusj-5588	908	13	system	system	NOUN
cusj-5588	908	14	.	.	PUNCT
cusj-5588	909	1	nature	nature	NOUN
cusj-5588	909	2	biotechnology	biotechnology	NOUN
cusj-5588	909	3	.	.	PUNCT
cusj-5588	910	1	23(7	23(7	NUM
cusj-5588	910	2	)	)	PUNCT
cusj-5588	910	3	,	,	PUNCT
cusj-5588	910	4	862	862	NUM
cusj-5588	910	5	-	-	SYM
cusj-5588	910	6	70	70	NUM
cusj-5588	910	7	.	.	PUNCT
cusj-5588	911	1	[	[	X
cusj-5588	911	2	13	13	NUM
cusj-5588	911	3	]	]	SYM
cusj-5588	911	4	li	li	NOUN
cusj-5588	911	5	g	g	PROPN
cusj-5588	911	6	,	,	PUNCT
cusj-5588	911	7	peskind	peskind	NOUN
cusj-5588	911	8	er	er	INTJ
cusj-5588	911	9	,	,	PUNCT
cusj-5588	911	10	millard	millard	PROPN
cusj-5588	911	11	sp	sp	PROPN
cusj-5588	911	12	,	,	PUNCT
cusj-5588	911	13	et	et	PROPN
cusj-5588	911	14	al	al	PROPN
cusj-5588	911	15	.	.	PUNCT
cusj-5588	912	1	(	(	PUNCT
cusj-5588	912	2	2009	2009	NUM
cusj-5588	912	3	)	)	PUNCT
cusj-5588	912	4	.	.	PUNCT
cusj-5588	913	1	cerebrospinal	cerebrospinal	ADJ
cusj-5588	913	2	fluid	fluid	ADJ
cusj-5588	913	3	concentration	concentration	NOUN
cusj-5588	913	4	of	of	ADP
cusj-5588	913	5	brain	brain	NOUN
cusj-5588	913	6	-	-	PUNCT
cusj-5588	913	7	derived	derive	VERB
cusj-5588	913	8	neurotrophic	neurotrophic	ADJ
cusj-5588	913	9	factor	factor	NOUN
cusj-5588	913	10	and	and	CCONJ
cusj-5588	913	11	cognitive	cognitive	ADJ
cusj-5588	913	12	function	function	NOUN
cusj-5588	913	13	in	in	ADP
cusj-5588	913	14	nondemented	nondemented	ADJ
cusj-5588	913	15	subjects	subject	NOUN
cusj-5588	913	16	.	.	PUNCT
cusj-5588	914	1	plos	plos	PROPN
cusj-5588	914	2	one	one	NUM
cusj-5588	914	3	.	.	PUNCT
cusj-5588	915	1	4	4	NUM
cusj-5588	915	2	:	:	PUNCT
cusj-5588	915	3	e5424	e5424	NOUN
cusj-5588	915	4	.	.	PUNCT
cusj-5588	916	1	[	[	X
cusj-5588	916	2	14	14	NUM
cusj-5588	916	3	]	]	PUNCT
cusj-5588	916	4	lindvall	lindvall	PROPN
cusj-5588	916	5	o	o	NOUN
cusj-5588	916	6	,	,	PUNCT
cusj-5588	916	7	brundin	brundin	VERB
cusj-5588	916	8	p	p	X
cusj-5588	916	9	,	,	PUNCT
cusj-5588	916	10	widner	widn	ADJ
cusj-5588	916	11	h	h	NOUN
cusj-5588	916	12	,	,	PUNCT
cusj-5588	916	13	rehncrona	rehncrona	PROPN
cusj-5588	916	14	s	s	PROPN
cusj-5588	916	15	,	,	PUNCT
cusj-5588	916	16	gustavii	gustavii	ADJ
cusj-5588	916	17	b	b	NOUN
cusj-5588	916	18	,	,	PUNCT
cusj-5588	916	19	frackowiak	frackowiak	NOUN
cusj-5588	916	20	r	r	NOUN
cusj-5588	916	21	,	,	PUNCT
cusj-5588	916	22	leenders	leenders	PROPN
cusj-5588	916	23	kl	kl	PROPN
cusj-5588	916	24	,	,	PUNCT
cusj-5588	916	25	sawle	sawle	VERB
cusj-5588	916	26	g	g	PROPN
cusj-5588	916	27	et	et	PROPN
cusj-5588	916	28	al	al	PROPN
cusj-5588	916	29	.	.	PROPN
cusj-5588	917	1	(	(	PUNCT
cusj-5588	917	2	1990	1990	NUM
cusj-5588	917	3	)	)	PUNCT
cusj-5588	917	4	.	.	PUNCT
cusj-5588	918	1	grafts	graft	NOUN
cusj-5588	918	2	of	of	ADP
cusj-5588	918	3	fetal	fetal	ADJ
cusj-5588	918	4	dopamine	dopamine	NOUN
cusj-5588	918	5	neurons	neuron	NOUN
cusj-5588	918	6	survive	survive	VERB
cusj-5588	918	7	and	and	CCONJ
cusj-5588	918	8	improve	improve	VERB
cusj-5588	918	9	motor	motor	NOUN
cusj-5588	918	10	function	function	NOUN
cusj-5588	918	11	in	in	ADP
cusj-5588	918	12	parkinson	parkinson	NOUN
cusj-5588	918	13	’s	’s	PART
cusj-5588	918	14	disease	disease	NOUN
cusj-5588	918	15	.	.	PUNCT
cusj-5588	919	1	science	science	NOUN
cusj-5588	919	2	.	.	PUNCT
cusj-5588	919	3	247(4942):574–577	247(4942):574–577	NUM
cusj-5588	920	1	[	[	X
cusj-5588	920	2	15	15	NUM
cusj-5588	920	3	]	]	X
cusj-5588	920	4	lindvall	lindvall	PROPN
cusj-5588	920	5	,	,	PUNCT
cusj-5588	920	6	o.	o.	PROPN
cusj-5588	920	7	,	,	PUNCT
cusj-5588	920	8	kokaia	kokaia	PROPN
cusj-5588	920	9	,	,	PUNCT
cusj-5588	920	10	z.	z.	PROPN
cusj-5588	920	11	(	(	PUNCT
cusj-5588	920	12	2010	2010	NUM
cusj-5588	920	13	)	)	PUNCT
cusj-5588	920	14	.	.	PUNCT
cusj-5588	921	1	stem	stem	NOUN
cusj-5588	921	2	cells	cell	NOUN
cusj-5588	921	3	in	in	ADP
cusj-5588	921	4	human	human	ADJ
cusj-5588	921	5	neurodegenerative	neurodegenerative	ADJ
cusj-5588	921	6	disorders	disorder	NOUN
cusj-5588	921	7	—	—	PUNCT
cusj-5588	921	8	time	time	NOUN
cusj-5588	921	9	for	for	ADP
cusj-5588	921	10	clinical	clinical	ADJ
cusj-5588	921	11	translation	translation	NOUN
cusj-5588	921	12	?	?	PUNCT
cusj-5588	922	1	journal	journal	NOUN
cusj-5588	922	2	of	of	ADP
cusj-5588	922	3	clinical	clinical	ADJ
cusj-5588	922	4	investigation	investigation	NOUN
cusj-5588	922	5	.	.	PUNCT
cusj-5588	923	1	120(1	120(1	NUM
cusj-5588	923	2	)	)	PUNCT
cusj-5588	923	3	,	,	PUNCT
cusj-5588	923	4	29	29	NUM
cusj-5588	923	5	-	-	SYM
cusj-5588	923	6	31	31	NUM
cusj-5588	923	7	.	.	PUNCT
cusj-5588	924	1	[	[	X
cusj-5588	924	2	16	16	NUM
cusj-5588	924	3	]	]	X
cusj-5588	924	4	kim	kim	PROPN
cusj-5588	924	5	t.	t.	PROPN
cusj-5588	924	6	e.	e.	PROPN
cusj-5588	924	7	,	,	PUNCT
cusj-5588	924	8	lee	lee	PROPN
cusj-5588	924	9	h.	h.	PROPN
cusj-5588	924	10	s.	s.	PROPN
cusj-5588	924	11	,	,	PUNCT
cusj-5588	924	12	lee	lee	PROPN
cusj-5588	924	13	y.	y.	PROPN
cusj-5588	924	14	b.	b.	PROPN
cusj-5588	924	15	,	,	PUNCT
cusj-5588	924	16	hong	hong	PROPN
cusj-5588	924	17	s.	s.	PROPN
cusj-5588	924	18	h.	h.	PROPN
cusj-5588	924	19	,	,	PUNCT
cusj-5588	924	20	lee	lee	PROPN
cusj-5588	924	21	y.	y.	PROPN
cusj-5588	924	22	s.	s.	PROPN
cusj-5588	924	23	,	,	PUNCT
cusj-5588	924	24	ichinose	ichinose	PROPN
cusj-5588	924	25	h.	h.	PROPN
cusj-5588	924	26	,	,	PUNCT
cusj-5588	924	27	et	et	PROPN
cusj-5588	924	28	al	al	PROPN
cusj-5588	924	29	.	.	PROPN
cusj-5588	924	30	.	.	PUNCT
cusj-5588	925	1	(	(	PUNCT
cusj-5588	925	2	2003	2003	NUM
cusj-5588	925	3	)	)	PUNCT
cusj-5588	925	4	.	.	PUNCT
cusj-5588	926	1	sonic	sonic	ADJ
cusj-5588	926	2	hedgehog	hedgehog	PROPN
cusj-5588	926	3	and	and	CCONJ
cusj-5588	926	4	fgf8	fgf8	PROPN
cusj-5588	926	5	collaborate	collaborate	VERB
cusj-5588	926	6	to	to	PART
cusj-5588	926	7	induce	induce	VERB
cusj-5588	926	8	dopaminergic	dopaminergic	ADJ
cusj-5588	926	9	phenotypes	phenotype	NOUN
cusj-5588	926	10	in	in	ADP
cusj-5588	926	11	the	the	DET
cusj-5588	926	12	nurr1	nurr1	NOUN
cusj-5588	926	13	-	-	PUNCT
cusj-5588	926	14	overexpressing	overexpresse	VERB
cusj-5588	926	15	neural	neural	ADJ
cusj-5588	926	16	stem	stem	NOUN
cusj-5588	926	17	cell	cell	NOUN
cusj-5588	926	18	.	.	PUNCT
cusj-5588	927	1	biochem	biochem	PROPN
cusj-5588	927	2	.	.	PUNCT
cusj-5588	928	1	biophys	biophy	NOUN
cusj-5588	928	2	.	.	PUNCT
cusj-5588	929	1	res	re	NOUN
cusj-5588	929	2	.	.	PUNCT
cusj-5588	930	1	commun	commun	PROPN
cusj-5588	930	2	.	.	PUNCT
cusj-5588	931	1	305	305	NUM
cusj-5588	931	2	,	,	PUNCT
cusj-5588	931	3	1040–1048	1040–1048	NUM
cusj-5588	931	4	.	.	PUNCT
cusj-5588	932	1	10.1016	10.1016	NUM
cusj-5588	932	2	/	/	SYM
cusj-5588	932	3	s0006291x(03)00879	s0006291x(03)00879	NUM
cusj-5588	932	4	-	-	SYM
cusj-5588	932	5	9	9	NUM
cusj-5588	932	6	[	[	SYM
cusj-5588	932	7	17	17	NUM
cusj-5588	932	8	]	]	X
cusj-5588	932	9	kordasiewicz	kordasiewicz	NOUN
cusj-5588	932	10	,	,	PUNCT
cusj-5588	932	11	h.	h.	PROPN
cusj-5588	932	12	b.	b.	PROPN
cusj-5588	932	13	,	,	PUNCT
cusj-5588	932	14	stanek	stanek	PROPN
cusj-5588	932	15	,	,	PUNCT
cusj-5588	932	16	l.	l.	PROPN
cusj-5588	932	17	m.	m.	PROPN
cusj-5588	932	18	,	,	PUNCT
cusj-5588	932	19	wancewicz	wancewicz	PROPN
cusj-5588	932	20	,	,	PUNCT
cusj-5588	932	21	e.	e.	PROPN
cusj-5588	932	22	v.	v.	PROPN
cusj-5588	932	23	,	,	PUNCT
cusj-5588	932	24	mazur	mazur	PROPN
cusj-5588	932	25	,	,	PUNCT
cusj-5588	932	26	c.	c.	PROPN
cusj-5588	932	27	,	,	PUNCT
cusj-5588	932	28	mcalonis	mcalonis	PROPN
cusj-5588	932	29	,	,	PUNCT
cusj-5588	932	30	m.	m.	NOUN
cusj-5588	932	31	m.	m.	NOUN
cusj-5588	932	32	,	,	PUNCT
cusj-5588	932	33	pytel	pytel	PROPN
cusj-5588	932	34	,	,	PUNCT
cusj-5588	932	35	k.	k.	PROPN
cusj-5588	932	36	a.	a.	PROPN
cusj-5588	932	37	,	,	PUNCT
cusj-5588	932	38	et	et	PROPN
cusj-5588	932	39	al	al	PROPN
cusj-5588	932	40	.	.	PUNCT
cusj-5588	932	41	(	(	PUNCT
cusj-5588	932	42	2012	2012	NUM
cusj-5588	932	43	)	)	PUNCT
cusj-5588	932	44	.	.	PUNCT
cusj-5588	933	1	sustained	sustain	VERB
cusj-5588	933	2	therapeutic	therapeutic	ADJ
cusj-5588	933	3	reversal	reversal	NOUN
cusj-5588	933	4	of	of	ADP
cusj-5588	933	5	huntington	huntington	PROPN
cusj-5588	933	6	’s	’s	PART
cusj-5588	933	7	disease	disease	NOUN
cusj-5588	933	8	by	by	ADP
cusj-5588	933	9	transient	transient	ADJ
cusj-5588	933	10	repression	repression	NOUN
cusj-5588	933	11	of	of	ADP
cusj-5588	933	12	huntingtin	huntingtin	ADJ
cusj-5588	933	13	synthesis	synthesis	NOUN
cusj-5588	933	14	.	.	PUNCT
cusj-5588	933	15	neuron	neuron	PROPN
cusj-5588	933	16	74	74	NUM
cusj-5588	933	17	,	,	PUNCT
cusj-5588	933	18	1031–1044	1031–1044	NUM
cusj-5588	933	19	.	.	PUNCT
cusj-5588	934	1	[	[	X
cusj-5588	934	2	18	18	NUM
cusj-5588	934	3	]	]	X
cusj-5588	934	4	kovacs	kovacs	PROPN
cusj-5588	934	5	,	,	PUNCT
cusj-5588	934	6	g.	g.	PROPN
cusj-5588	934	7	(	(	PUNCT
cusj-5588	934	8	2016	2016	NUM
cusj-5588	934	9	)	)	PUNCT
cusj-5588	934	10	.	.	PUNCT
cusj-5588	935	1	molecular	molecular	ADJ
cusj-5588	935	2	pathological	pathological	ADJ
cusj-5588	935	3	classification	classification	NOUN
cusj-5588	935	4	of	of	ADP
cusj-5588	935	5	neurodegenerative	neurodegenerative	ADJ
cusj-5588	935	6	diseases	disease	NOUN
cusj-5588	935	7	:	:	PUNCT
cusj-5588	935	8	turning	turn	VERB
cusj-5588	935	9	towards	towards	ADP
cusj-5588	935	10	precision	precision	NOUN
cusj-5588	935	11	medicine	medicine	NOUN
cusj-5588	935	12	.	.	PUNCT
cusj-5588	936	1	int	int	NOUN
cusj-5588	936	2	.	.	PUNCT
cusj-5588	937	1	j.	j.	PROPN
cusj-5588	937	2	mol	mol	PROPN
cusj-5588	937	3	.	.	PUNCT
cusj-5588	938	1	sci	sci	PROPN
cusj-5588	938	2	.	.	PROPN
cusj-5588	938	3	17(189	17(189	PROPN
cusj-5588	938	4	)	)	PUNCT
cusj-5588	938	5	,	,	PUNCT
cusj-5588	938	6	1	1	NUM
cusj-5588	938	7	-	-	SYM
cusj-5588	938	8	21	21	NUM
cusj-5588	938	9	.	.	PUNCT
cusj-5588	939	1	[	[	X
cusj-5588	939	2	19	19	NUM
cusj-5588	939	3	]	]	X
cusj-5588	939	4	kumar	kumar	PROPN
cusj-5588	939	5	,	,	PUNCT
cusj-5588	939	6	a.	a.	PROPN
cusj-5588	939	7	,	,	PUNCT
cusj-5588	939	8	narayanan	narayanan	PROPN
cusj-5588	939	9	,	,	PUNCT
cusj-5588	939	10	k.	k.	PROPN
cusj-5588	939	11	,	,	PUNCT
cusj-5588	939	12	chaudhary	chaudhary	PROPN
cusj-5588	939	13	,	,	PUNCT
cusj-5588	939	14	r.	r.	PROPN
cusj-5588	939	15	,	,	PUNCT
cusj-5588	939	16	mishra	mishra	PROPN
cusj-5588	939	17	,	,	PUNCT
cusj-5588	939	18	s.	s.	PROPN
cusj-5588	939	19	2016	2016	NUM
cusj-5588	939	20	.	.	PUNCT
cusj-5588	940	1	current	current	ADJ
cusj-5588	940	2	perspective	perspective	NOUN
cusj-5588	940	3	of	of	ADP
cusj-5588	940	4	stem	stem	NOUN
cusj-5588	940	5	cell	cell	NOUN
cusj-5588	940	6	therapy	therapy	NOUN
cusj-5588	940	7	in	in	ADP
cusj-5588	940	8	neurodegenerative	neurodegenerative	ADJ
cusj-5588	940	9	and	and	CCONJ
cusj-5588	940	10	metabolic	metabolic	NOUN
cusj-5588	940	11	diseases	disease	NOUN
cusj-5588	940	12	.	.	PUNCT
cusj-5588	941	1	mol	mol	PROPN
cusj-5588	941	2	.	.	PUNCT
cusj-5588	941	3	neurobiol	neurobiol	PROPN
cusj-5588	941	4	.	.	PUNCT
cusj-5588	942	1	,	,	PUNCT
cusj-5588	942	2	online	online	INTJ
cusj-5588	942	3	.	.	PUNCT
cusj-5588	943	1	[	[	X
cusj-5588	943	2	20	20	NUM
cusj-5588	943	3	]	]	PUNCT
cusj-5588	943	4	sarkis	sarkis	PROPN
cusj-5588	943	5	,	,	PUNCT
cusj-5588	943	6	c.	c.	PROPN
cusj-5588	943	7	&	&	CCONJ
cusj-5588	943	8	mallet	mallet	PROPN
cusj-5588	943	9	,	,	PUNCT
cusj-5588	943	10	j.	j.	PROPN
cusj-5588	943	11	(	(	PUNCT
cusj-5588	943	12	2005	2005	NUM
cusj-5588	943	13	)	)	PUNCT
cusj-5588	943	14	.	.	PUNCT
cusj-5588	944	1	gene	gene	NOUN
cusj-5588	944	2	therapy	therapy	NOUN
cusj-5588	944	3	.	.	PUNCT
cusj-5588	945	1	in	in	ADP
cusj-5588	945	2	beal	beal	NOUN
cusj-5588	945	3	,	,	PUNCT
cusj-5588	945	4	m.	m.	NOUN
cusj-5588	945	5	,	,	PUNCT
cusj-5588	945	6	lang	lang	PROPN
cusj-5588	945	7	,	,	PUNCT
cusj-5588	945	8	a.	a.	PROPN
cusj-5588	945	9	,	,	PUNCT
cusj-5588	945	10	ludolph	ludolph	VERB
cusj-5588	945	11	,	,	PUNCT
cusj-5588	945	12	a.	a.	NOUN
cusj-5588	945	13	(	(	PUNCT
cusj-5588	945	14	eds	eds	PROPN
cusj-5588	945	15	.	.	PUNCT
cusj-5588	945	16	)	)	PUNCT
cusj-5588	946	1	,	,	PUNCT
cusj-5588	946	2	neurodegenerative	neurodegenerative	ADJ
cusj-5588	946	3	diseases	disease	NOUN
cusj-5588	946	4	:	:	PUNCT
cusj-5588	946	5	neurobiology	neurobiology	NOUN
cusj-5588	946	6	,	,	PUNCT
cusj-5588	946	7	pathogenesis	pathogenesis	NOUN
cusj-5588	946	8	and	and	CCONJ
cusj-5588	946	9	therapeutics	therapeutic	NOUN
cusj-5588	946	10	(	(	PUNCT
cusj-5588	946	11	329	329	NUM
cusj-5588	946	12	-	-	SYM
cusj-5588	946	13	40	40	NUM
cusj-5588	946	14	)	)	PUNCT
cusj-5588	946	15	.	.	PUNCT
cusj-5588	947	1	cambridge	cambridge	PROPN
cusj-5588	947	2	university	university	PROPN
cusj-5588	947	3	press	press	NOUN
cusj-5588	947	4	.	.	PUNCT
cusj-5588	948	1	[	[	X
cusj-5588	948	2	21	21	NUM
cusj-5588	948	3	]	]	X
cusj-5588	948	4	singh	singh	PROPN
cusj-5588	948	5	,	,	PUNCT
cusj-5588	948	6	s.	s.	PROPN
cusj-5588	948	7	,	,	PUNCT
cusj-5588	948	8	srivastava	srivastava	PROPN
cusj-5588	948	9	,	,	PUNCT
cusj-5588	948	10	a.	a.	PROPN
cusj-5588	948	11	,	,	PUNCT
cusj-5588	948	12	srivastava	srivastava	PROPN
cusj-5588	948	13	,	,	PUNCT
cusj-5588	948	14	p.	p.	PROPN
cusj-5588	948	15	,	,	PUNCT
cusj-5588	948	16	dhuriya	dhuriya	PROPN
cusj-5588	948	17	,	,	PUNCT
cusj-5588	948	18	y.	y.	PROPN
cusj-5588	948	19	2016	2016	NUM
cusj-5588	948	20	.	.	PUNCT
cusj-5588	949	1	advances	advance	NOUN
cusj-5588	949	2	in	in	ADP
cusj-5588	949	3	stem	stem	NOUN
cusj-5588	949	4	cell	cell	NOUN
cusj-5588	949	5	researcha	researcha	PROPN
cusj-5588	949	6	ray	ray	NOUN
cusj-5588	949	7	of	of	ADP
cusj-5588	949	8	hope	hope	NOUN
cusj-5588	949	9	in	in	ADP
cusj-5588	949	10	better	well	ADJ
cusj-5588	949	11	diagnosis	diagnosis	NOUN
cusj-5588	949	12	and	and	CCONJ
cusj-5588	949	13	prognosis	prognosis	NOUN
cusj-5588	949	14	in	in	ADP
cusj-5588	949	15	neurodegenerative	neurodegenerative	ADJ
cusj-5588	949	16	diseases	disease	NOUN
cusj-5588	949	17	.	.	PUNCT
cusj-5588	950	1	frontiers	frontier	NOUN
cusj-5588	950	2	in	in	ADP
cusj-5588	950	3	molecular	molecular	ADJ
cusj-5588	950	4	biosciences	bioscience	NOUN
cusj-5588	950	5	.	.	PUNCT
cusj-5588	950	6	3(72	3(72	NUM
cusj-5588	950	7	)	)	PUNCT
cusj-5588	950	8	,	,	PUNCT
cusj-5588	950	9	1	1	NUM
cusj-5588	950	10	-	-	SYM
cusj-5588	950	11	10	10	NUM
cusj-5588	950	12	.	.	PUNCT
cusj-5588	951	1	[	[	X
cusj-5588	951	2	22	22	NUM
cusj-5588	951	3	]	]	X
cusj-5588	951	4	tuszynski	tuszynski	PROPN
cusj-5588	951	5	,	,	PUNCT
cusj-5588	951	6	m.	m.	PROPN
cusj-5588	951	7	h.	h.	PROPN
cusj-5588	951	8	(	(	PUNCT
cusj-5588	951	9	2007	2007	NUM
cusj-5588	951	10	)	)	PUNCT
cusj-5588	951	11	.	.	PUNCT
cusj-5588	952	1	nerve	nerve	NOUN
cusj-5588	952	2	growth	growth	NOUN
cusj-5588	952	3	factor	factor	NOUN
cusj-5588	952	4	gene	gene	NOUN
cusj-5588	952	5	therapy	therapy	NOUN
cusj-5588	952	6	in	in	ADP
cusj-5588	952	7	alzheimer	alzheimer	PROPN
cusj-5588	952	8	disease	disease	PROPN
cusj-5588	952	9	.	.	PUNCT
cusj-5588	953	1	alzheimer	alzheimer	PROPN
cusj-5588	953	2	dis	dis	PROPN
cusj-5588	953	3	.	.	PUNCT
cusj-5588	954	1	assoc	assoc	PROPN
cusj-5588	954	2	.	.	PUNCT
cusj-5588	955	1	disord	disord	PROPN
cusj-5588	955	2	.	.	PUNCT
cusj-5588	956	1	21	21	NUM
cusj-5588	956	2	,	,	PUNCT
cusj-5588	956	3	179–189	179–189	NUM
cusj-5588	956	4	.	.	PUNCT
cusj-5588	957	1	18	18	NUM
cusj-5588	957	2	_	_	PUNCT
cusj-5588	958	1	_	_	PUNCT
cusj-5588	959	1	_	_	PUNCT
cusj-5588	960	1	_	_	PUNCT
cusj-5588	961	1	_	_	PUNCT
cusj-5588	962	1	_	_	PUNCT
cusj-5588	963	1	_	_	PUNCT
cusj-5588	964	1	_	_	PUNCT
cusj-5588	965	1	_	_	PUNCT
cusj-5588	966	1	_	_	PUNCT
cusj-5588	967	1	_	_	PUNCT
cusj-5588	968	1	_	_	PUNCT
cusj-5588	969	1	_	_	PUNCT
cusj-5588	970	1	_	_	PUNCT
cusj-5588	971	1	_	_	PUNCT
cusj-5588	972	1	_	_	PUNCT
cusj-5588	973	1	_	_	PUNCT
cusj-5588	974	1	_	_	PUNCT
cusj-5588	975	1	_	_	PUNCT
cusj-5588	976	1	_	_	PUNCT
cusj-5588	977	1	_	_	PUNCT
cusj-5588	978	1	_	_	PUNCT
cusj-5588	979	1	_	_	PUNCT
cusj-5588	980	1	_	_	PUNCT
cusj-5588	981	1	_	_	PUNCT
cusj-5588	982	1	_	_	PUNCT
cusj-5588	983	1	_	_	PUNCT
cusj-5588	984	1	_	_	PUNCT
cusj-5588	985	1	_	_	PUNCT
cusj-5588	986	1	_	_	PUNCT
cusj-5588	987	1	_	_	PUNCT
cusj-5588	988	1	_	_	PUNCT
cusj-5588	989	1	_	_	PUNCT
cusj-5588	990	1	_	_	PUNCT
cusj-5588	991	1	_	_	PUNCT
cusj-5588	992	1	_	_	PUNCT
cusj-5588	993	1	_	_	PUNCT
cusj-5588	994	1	_	_	PUNCT
cusj-5588	995	1	_	_	PUNCT
cusj-5588	996	1	_	_	PUNCT
cusj-5588	997	1	_	_	PUNCT
cusj-5588	998	1	_	_	PUNCT
cusj-5588	999	1	_	_	PUNCT
cusj-5588	1000	1	_	_	PUNCT
cusj-5588	1001	1	_	_	PUNCT
cusj-5588	1002	1	_	_	PUNCT
cusj-5588	1003	1	_	_	PUNCT
cusj-5588	1004	1	_	_	PUNCT
cusj-5588	1005	1	_	_	PUNCT
cusj-5588	1006	1	_	_	PUNCT
cusj-5588	1007	1	_	_	PUNCT
cusj-5588	1008	1	_	_	PUNCT
cusj-5588	1009	1	_	_	PUNCT
cusj-5588	1010	1	_	_	PUNCT
cusj-5588	1011	1	_	_	PUNCT
cusj-5588	1012	1	_	_	PUNCT
cusj-5588	1013	1	_	_	PUNCT
cusj-5588	1014	1	_	_	PUNCT
cusj-5588	1015	1	_	_	PUNCT
cusj-5588	1016	1	_	_	PUNCT
cusj-5588	1017	1	_	_	PUNCT
cusj-5588	1018	1	_	_	PUNCT
cusj-5588	1019	1	_	_	PUNCT
cusj-5588	1020	1	_	_	PUNCT
cusj-5588	1021	1	_	_	PUNCT
cusj-5588	1022	1	_	_	PUNCT
cusj-5588	1023	1	_	_	PUNCT
cusj-5588	1024	1	_	_	PUNCT
cusj-5588	1025	1	_	_	PUNCT
cusj-5588	1026	1	_	_	PUNCT
cusj-5588	1027	1	_	_	PUNCT
cusj-5588	1028	1	_	_	PUNCT
cusj-5588	1029	1	_	_	PUNCT
cusj-5588	1030	1	_	_	PUNCT
cusj-5588	1031	1	_	_	PUNCT
cusj-5588	1032	1	_	_	PUNCT
cusj-5588	1033	1	_	_	PUNCT
cusj-5588	1034	1	_	_	PUNCT
cusj-5588	1035	1	_	_	PUNCT
cusj-5588	1036	1	_	_	PUNCT
cusj-5588	1036	2	cusj	cusj	VERB
cusj-5588	1036	3	2018	2018	NUM
cusj-5588	1036	4	[	[	X
cusj-5588	1036	5	23	23	NUM
cusj-5588	1036	6	]	]	X
cusj-5588	1036	7	tuszynski	tuszynski	PROPN
cusj-5588	1036	8	,	,	PUNCT
cusj-5588	1036	9	m.	m.	PROPN
cusj-5588	1036	10	h.	h.	PROPN
cusj-5588	1036	11	,	,	PUNCT
cusj-5588	1036	12	thal	thal	PROPN
cusj-5588	1036	13	,	,	PUNCT
cusj-5588	1036	14	l.	l.	PROPN
cusj-5588	1036	15	,	,	PUNCT
cusj-5588	1036	16	pay	pay	NOUN
cusj-5588	1036	17	,	,	PUNCT
cusj-5588	1036	18	m.	m.	NOUN
cusj-5588	1036	19	,	,	PUNCT
cusj-5588	1036	20	salmon	salmon	NOUN
cusj-5588	1036	21	,	,	PUNCT
cusj-5588	1036	22	d.	d.	PROPN
cusj-5588	1036	23	p.	p.	PROPN
cusj-5588	1036	24	,	,	PUNCT
cusj-5588	1036	25	bakay	bakay	PROPN
cusj-5588	1036	26	,	,	PUNCT
cusj-5588	1036	27	r.	r.	PROPN
cusj-5588	1036	28	,	,	PUNCT
cusj-5588	1036	29	patel	patel	PROPN
cusj-5588	1036	30	,	,	PUNCT
cusj-5588	1036	31	p.	p.	PROPN
cusj-5588	1036	32	,	,	PUNCT
cusj-5588	1036	33	et	et	PROPN
cusj-5588	1036	34	al	al	PROPN
cusj-5588	1036	35	.	.	PUNCT
cusj-5588	1037	1	(	(	PUNCT
cusj-5588	1037	2	2005	2005	NUM
cusj-5588	1037	3	)	)	PUNCT
cusj-5588	1037	4	.	.	PUNCT
cusj-5588	1038	1	a	a	DET
cusj-5588	1038	2	phase	phase	NOUN
cusj-5588	1038	3	1	1	NUM
cusj-5588	1038	4	clinical	clinical	ADJ
cusj-5588	1038	5	trial	trial	NOUN
cusj-5588	1038	6	of	of	ADP
cusj-5588	1038	7	nerve	nerve	NOUN
cusj-5588	1038	8	growth	growth	NOUN
cusj-5588	1038	9	factor	factor	NOUN
cusj-5588	1038	10	gene	gene	NOUN
cusj-5588	1038	11	therapy	therapy	NOUN
cusj-5588	1038	12	for	for	ADP
cusj-5588	1038	13	alzheimer	alzheimer	PROPN
cusj-5588	1038	14	disease	disease	NOUN
cusj-5588	1038	15	.	.	PUNCT
cusj-5588	1039	1	nat	nat	PROPN
cusj-5588	1039	2	.	.	PUNCT
cusj-5588	1039	3	med	med	PROPN
cusj-5588	1039	4	.	.	PROPN
cusj-5588	1040	1	11	11	NUM
cusj-5588	1040	2	,	,	PUNCT
cusj-5588	1040	3	551–555	551–555	NUM
cusj-5588	1040	4	.	.	PUNCT
cusj-5588	1041	1	[	[	X
cusj-5588	1041	2	24	24	NUM
cusj-5588	1041	3	]	]	X
cusj-5588	1041	4	mizuno	mizuno	PROPN
cusj-5588	1041	5	,	,	PUNCT
cusj-5588	1041	6	y.	y.	PROPN
cusj-5588	1041	7	(	(	PUNCT
cusj-5588	1041	8	2014	2014	NUM
cusj-5588	1041	9	)	)	PUNCT
cusj-5588	1041	10	.	.	PUNCT
cusj-5588	1042	1	recent	recent	ADJ
cusj-5588	1042	2	research	research	NOUN
cusj-5588	1042	3	progress	progress	NOUN
cusj-5588	1042	4	in	in	ADP
cusj-5588	1042	5	and	and	CCONJ
cusj-5588	1042	6	future	future	ADJ
cusj-5588	1042	7	perspective	perspective	NOUN
cusj-5588	1042	8	on	on	ADP
cusj-5588	1042	9	treatment	treatment	NOUN
cusj-5588	1042	10	of	of	ADP
cusj-5588	1042	11	parkinson	parkinson	NOUN
cusj-5588	1042	12	’s	’s	PART
cusj-5588	1042	13	disease	disease	NOUN
cusj-5588	1042	14	.	.	PUNCT
cusj-5588	1043	1	integr	integr	PROPN
cusj-5588	1043	2	med	med	PROPN
cusj-5588	1043	3	int	int	PROPN
cusj-5588	1043	4	.	.	PUNCT
cusj-5588	1044	1	1(2	1(2	NUM
cusj-5588	1044	2	)	)	PUNCT
cusj-5588	1044	3	,	,	PUNCT
cusj-5588	1044	4	67	67	NUM
cusj-5588	1044	5	-	-	SYM
cusj-5588	1044	6	79	79	NUM
cusj-5588	1044	7	.	.	PUNCT
cusj-5588	1045	1	[	[	X
cusj-5588	1045	2	25	25	NUM
cusj-5588	1045	3	]	]	X
cusj-5588	1045	4	rafii	rafii	NOUN
cusj-5588	1045	5	,	,	PUNCT
cusj-5588	1045	6	m.s	m.s	PROPN
cusj-5588	1045	7	.	.	PROPN
cusj-5588	1045	8	et	et	PROPN
cusj-5588	1045	9	al	al	PROPN
cusj-5588	1045	10	.	.	PROPN
cusj-5588	1046	1	(	(	PUNCT
cusj-5588	1046	2	2014	2014	NUM
cusj-5588	1046	3	)	)	PUNCT
cusj-5588	1046	4	.	.	PUNCT
cusj-5588	1047	1	a	a	DET
cusj-5588	1047	2	phase1	phase1	NOUN
cusj-5588	1047	3	study	study	NOUN
cusj-5588	1047	4	of	of	ADP
cusj-5588	1047	5	stereotactic	stereotactic	ADJ
cusj-5588	1047	6	gene	gene	NOUN
cusj-5588	1047	7	delivery	delivery	NOUN
cusj-5588	1047	8	of	of	ADP
cusj-5588	1047	9	aav2	aav2	PROPN
cusj-5588	1047	10	-	-	PUNCT
cusj-5588	1047	11	ngf	ngf	PROPN
cusj-5588	1047	12	for	for	ADP
cusj-5588	1047	13	alzheimer	alzheimer	PROPN
cusj-5588	1047	14	's	's	PART
cusj-5588	1047	15	disease	disease	NOUN
cusj-5588	1047	16	.	.	PUNCT
cusj-5588	1048	1	alzheimers	alzheimers	PROPN
cusj-5588	1048	2	dement	dement	PROPN
cusj-5588	1048	3	.	.	PUNCT
cusj-5588	1049	1	,	,	PUNCT
cusj-5588	1049	2	10	10	NUM
cusj-5588	1049	3	,	,	PUNCT
cusj-5588	1049	4	pp	pp	ADJ
cusj-5588	1049	5	.	.	PUNCT
cusj-5588	1050	1	571–581	571–581	NUM
cusj-5588	1050	2	[	[	X
cusj-5588	1050	3	26	26	NUM
cusj-5588	1050	4	]	]	X
cusj-5588	1050	5	mcbride	mcbride	PROPN
cusj-5588	1050	6	jl	jl	PROPN
cusj-5588	1050	7	,	,	PUNCT
cusj-5588	1050	8	behrstock	behrstock	PROPN
cusj-5588	1050	9	sp	sp	PROPN
cusj-5588	1050	10	,	,	PUNCT
cusj-5588	1050	11	chen	chen	PROPN
cusj-5588	1050	12	ey	ey	PROPN
cusj-5588	1050	13	,	,	PUNCT
cusj-5588	1050	14	et	et	PROPN
cusj-5588	1050	15	al	al	PROPN
cusj-5588	1050	16	.	.	PUNCT
cusj-5588	1051	1	human	human	ADJ
cusj-5588	1051	2	neural	neural	ADJ
cusj-5588	1051	3	stem	stem	NOUN
cusj-5588	1051	4	cell	cell	NOUN
cusj-5588	1051	5	transplants	transplant	NOUN
cusj-5588	1051	6	improve	improve	VERB
cusj-5588	1051	7	motor	motor	NOUN
cusj-5588	1051	8	function	function	NOUN
cusj-5588	1051	9	in	in	ADP
cusj-5588	1051	10	a	a	DET
cusj-5588	1051	11	rat	rat	NOUN
cusj-5588	1051	12	model	model	NOUN
cusj-5588	1051	13	of	of	ADP
cusj-5588	1051	14	huntington	huntington	PROPN
cusj-5588	1051	15	’s	’s	PART
cusj-5588	1051	16	disease	disease	NOUN
cusj-5588	1051	17	.	.	PUNCT
cusj-5588	1052	1	j	j	PROPN
cusj-5588	1052	2	comp	comp	PROPN
cusj-5588	1052	3	neurol	neurol	PROPN
cusj-5588	1052	4	.	.	PUNCT
cusj-5588	1053	1	2004	2004	NUM
cusj-5588	1053	2	;	;	PUNCT
cusj-5588	1053	3	475:211–219	475:211–219	NUM
cusj-5588	1053	4	.	.	PUNCT
cusj-5588	1054	1	[	[	X
cusj-5588	1054	2	27	27	NUM
cusj-5588	1054	3	]	]	PUNCT
cusj-5588	1054	4	o’connor	o’connor	ADV
cusj-5588	1054	5	,	,	PUNCT
cusj-5588	1054	6	d.	d.	PROPN
cusj-5588	1054	7	&	&	CCONJ
cusj-5588	1054	8	boulis	boulis	PROPN
cusj-5588	1054	9	,	,	PUNCT
cusj-5588	1054	10	n.	n.	NOUN
cusj-5588	1054	11	(	(	PUNCT
cusj-5588	1054	12	2015	2015	NUM
cusj-5588	1054	13	)	)	PUNCT
cusj-5588	1054	14	.	.	PUNCT
cusj-5588	1055	1	gene	gene	NOUN
cusj-5588	1055	2	therapy	therapy	NOUN
cusj-5588	1055	3	for	for	ADP
cusj-5588	1055	4	neurodegenerative	neurodegenerative	ADJ
cusj-5588	1055	5	diseases	disease	NOUN
cusj-5588	1055	6	.	.	PUNCT
cusj-5588	1056	1	trends	trend	NOUN
cusj-5588	1056	2	in	in	ADP
cusj-5588	1056	3	molecular	molecular	ADJ
cusj-5588	1056	4	medicine	medicine	NOUN
cusj-5588	1056	5	.	.	PUNCT
cusj-5588	1057	1	21(8	21(8	NUM
cusj-5588	1057	2	)	)	PUNCT
cusj-5588	1057	3	,	,	PUNCT
cusj-5588	1057	4	504	504	NUM
cusj-5588	1057	5	-	-	SYM
cusj-5588	1057	6	11	11	NUM
cusj-5588	1057	7	.	.	PUNCT
cusj-5588	1058	1	[	[	X
cusj-5588	1058	2	28	28	NUM
cusj-5588	1058	3	]	]	X
cusj-5588	1058	4	precious	precious	ADJ
cusj-5588	1058	5	sv	sv	PROPN
cusj-5588	1058	6	,	,	PUNCT
cusj-5588	1058	7	rosser	rosser	PROPN
cusj-5588	1058	8	ae	ae	PROPN
cusj-5588	1058	9	(	(	PUNCT
cusj-5588	1058	10	2012	2012	NUM
cusj-5588	1058	11	)	)	PUNCT
cusj-5588	1058	12	producing	produce	VERB
cusj-5588	1058	13	striatal	striatal	ADJ
cusj-5588	1058	14	phenotypes	phenotype	NOUN
cusj-5588	1058	15	for	for	ADP
cusj-5588	1058	16	transplantation	transplantation	NOUN
cusj-5588	1058	17	in	in	ADP
cusj-5588	1058	18	huntington	huntington	PROPN
cusj-5588	1058	19	’s	’s	PART
cusj-5588	1058	20	disease	disease	NOUN
cusj-5588	1058	21	.	.	PUNCT
cusj-5588	1059	1	exp	exp	NOUN
cusj-5588	1059	2	biol	biol	PROPN
cusj-5588	1059	3	med	me	VERB
cusj-5588	1059	4	237(4):343–351	237(4):343–351	PROPN
cusj-5588	1060	1	[	[	X
cusj-5588	1060	2	29	29	NUM
cusj-5588	1060	3	]	]	PUNCT
cusj-5588	1060	4	lewitt	lewitt	NOUN
cusj-5588	1060	5	,	,	PUNCT
cusj-5588	1060	6	p.	p.	NOUN
cusj-5588	1060	7	et	et	NOUN
cusj-5588	1061	1	al	al	PROPN
cusj-5588	1061	2	.	.	PROPN
cusj-5588	1061	3	(	(	PUNCT
cusj-5588	1061	4	2011	2011	NUM
cusj-5588	1061	5	)	)	PUNCT
cusj-5588	1061	6	.	.	PUNCT
cusj-5588	1062	1	aav2	aav2	PROPN
cusj-5588	1062	2	-	-	PUNCT
cusj-5588	1062	3	gad	gad	PROPN
cusj-5588	1062	4	gene	gene	NOUN
cusj-5588	1062	5	therapy	therapy	NOUN
cusj-5588	1062	6	for	for	ADP
cusj-5588	1062	7	advanced	advanced	ADJ
cusj-5588	1062	8	parkinson	parkinson	NOUN
cusj-5588	1062	9	's	's	PART
cusj-5588	1062	10	disease	disease	NOUN
cusj-5588	1062	11	:	:	PUNCT
cusj-5588	1062	12	a	a	DET
cusj-5588	1062	13	double	double	ADJ
cusj-5588	1062	14	-	-	PUNCT
cusj-5588	1062	15	blind	blind	ADJ
cusj-5588	1062	16	,	,	PUNCT
cusj-5588	1062	17	shamsurgery	shamsurgery	PROPN
cusj-5588	1062	18	controlled	control	VERB
cusj-5588	1062	19	,	,	PUNCT
cusj-5588	1062	20	randomised	randomise	VERB
cusj-5588	1062	21	trial	trial	NOUN
cusj-5588	1062	22	.	.	PUNCT
cusj-5588	1063	1	lancet	lancet	PROPN
cusj-5588	1063	2	neurol	neurol	PROPN
cusj-5588	1063	3	.	.	PUNCT
cusj-5588	1064	1	,	,	PUNCT
cusj-5588	1064	2	10	10	NUM
cusj-5588	1064	3	,	,	PUNCT
cusj-5588	1064	4	pp	pp	ADJ
cusj-5588	1064	5	.	.	PUNCT
cusj-5588	1065	1	309–319	309–319	NUM
cusj-5588	1065	2	[	[	SYM
cusj-5588	1065	3	30	30	NUM
cusj-5588	1065	4	]	]	X
cusj-5588	1065	5	xuan	xuan	PROPN
cusj-5588	1065	6	ag	ag	PROPN
cusj-5588	1065	7	,	,	PUNCT
cusj-5588	1065	8	long	long	ADJ
cusj-5588	1065	9	dh	dh	NOUN
cusj-5588	1065	10	,	,	PUNCT
cusj-5588	1065	11	gu	gu	NOUN
cusj-5588	1065	12	hg	hg	PROPN
cusj-5588	1065	13	,	,	PUNCT
cusj-5588	1065	14	et	et	PROPN
cusj-5588	1065	15	al	al	PROPN
cusj-5588	1065	16	.	.	PUNCT
cusj-5588	1065	17	(	(	PUNCT
cusj-5588	1065	18	2008	2008	NUM
cusj-5588	1065	19	)	)	PUNCT
cusj-5588	1065	20	.	.	PUNCT
cusj-5588	1066	1	bdnf	bdnf	PROPN
cusj-5588	1066	2	improves	improve	VERB
cusj-5588	1066	3	the	the	DET
cusj-5588	1066	4	effects	effect	NOUN
cusj-5588	1066	5	of	of	ADP
cusj-5588	1066	6	neural	neural	ADJ
cusj-5588	1066	7	stem	stem	NOUN
cusj-5588	1066	8	cells	cell	NOUN
cusj-5588	1066	9	on	on	ADP
cusj-5588	1066	10	the	the	DET
cusj-5588	1066	11	rat	rat	NOUN
cusj-5588	1066	12	model	model	NOUN
cusj-5588	1066	13	of	of	ADP
cusj-5588	1066	14	alzheimer	alzheimer	PROPN
cusj-5588	1066	15	’s	’s	PART
cusj-5588	1066	16	disease	disease	NOUN
cusj-5588	1066	17	with	with	ADP
cusj-5588	1066	18	unilateral	unilateral	ADJ
cusj-5588	1066	19	lesion	lesion	NOUN
cusj-5588	1066	20	of	of	ADP
cusj-5588	1066	21	fimbria	fimbria	NOUN
cusj-5588	1066	22	-	-	PUNCT
cusj-5588	1066	23	fornix	fornix	PROPN
cusj-5588	1066	24	.	.	PUNCT
cusj-5588	1067	1	neurosci	neurosci	PROPN
cusj-5588	1067	2	lett	lett	PROPN
cusj-5588	1067	3	.	.	PUNCT
cusj-5588	1068	1	440:331–335	440:331–335	NUM
cusj-5588	1068	2	.	.	PUNCT
cusj-5588	1069	1	[	[	X
cusj-5588	1069	2	31	31	NUM
cusj-5588	1069	3	]	]	SYM
cusj-5588	1069	4	viegas	viegas	X
cusj-5588	1069	5	p	p	NOUN
cusj-5588	1069	6	,	,	PUNCT
cusj-5588	1069	7	nicoleau	nicoleau	PROPN
cusj-5588	1069	8	c	c	NOUN
cusj-5588	1069	9	,	,	PUNCT
cusj-5588	1069	10	perrier	perrier	PROPN
cusj-5588	1069	11	al	al	PROPN
cusj-5588	1069	12	(	(	PUNCT
cusj-5588	1069	13	2011	2011	NUM
cusj-5588	1069	14	)	)	PUNCT
cusj-5588	1069	15	derivation	derivation	NOUN
cusj-5588	1069	16	of	of	ADP
cusj-5588	1069	17	striatal	striatal	ADJ
cusj-5588	1069	18	neurons	neuron	NOUN
cusj-5588	1069	19	from	from	ADP
cusj-5588	1069	20	human	human	ADJ
cusj-5588	1069	21	stem	stem	NOUN
cusj-5588	1069	22	cells	cell	NOUN
cusj-5588	1069	23	.	.	PUNCT
cusj-5588	1070	1	prog	prog	NOUN
cusj-5588	1070	2	brain	brain	NOUN
cusj-5588	1070	3	res	re	NOUN
cusj-5588	1070	4	200:373–404	200:373–404	NOUN
cusj-5588	1070	5	[	[	X
cusj-5588	1070	6	32	32	NUM
cusj-5588	1070	7	]	]	PUNCT
cusj-5588	1070	8	wahlberg	wahlberg	PROPN
cusj-5588	1070	9	,	,	PUNCT
cusj-5588	1070	10	l.	l.	PROPN
cusj-5588	1070	11	u.	u.	PROPN
cusj-5588	1070	12	,	,	PUNCT
cusj-5588	1070	13	lind	lind	PROPN
cusj-5588	1070	14	,	,	PUNCT
cusj-5588	1070	15	g.	g.	PROPN
cusj-5588	1070	16	,	,	PUNCT
cusj-5588	1070	17	almqvist	almqvist	NOUN
cusj-5588	1070	18	,	,	PUNCT
cusj-5588	1070	19	p.	p.	NOUN
cusj-5588	1070	20	m.	m.	NOUN
cusj-5588	1070	21	,	,	PUNCT
cusj-5588	1070	22	kusk	kusk	NOUN
cusj-5588	1070	23	,	,	PUNCT
cusj-5588	1070	24	p.	p.	NOUN
cusj-5588	1070	25	,	,	PUNCT
cusj-5588	1070	26	tornøe	tornøe	PROPN
cusj-5588	1070	27	,	,	PUNCT
cusj-5588	1070	28	j.	j.	PROPN
cusj-5588	1070	29	,	,	PUNCT
cusj-5588	1070	30	juliusson	juliusson	PROPN
cusj-5588	1070	31	,	,	PUNCT
cusj-5588	1070	32	b.	b.	PROPN
cusj-5588	1070	33	,	,	PUNCT
cusj-5588	1070	34	.	.	PUNCT
cusj-5588	1070	35	.	.	PUNCT
cusj-5588	1071	1	.	.	PUNCT
cusj-5588	1072	1	linderoth	linderoth	PROPN
cusj-5588	1072	2	,	,	PUNCT
cusj-5588	1072	3	b.	b.	PROPN
cusj-5588	1072	4	(	(	PUNCT
cusj-5588	1072	5	2012	2012	NUM
cusj-5588	1072	6	)	)	PUNCT
cusj-5588	1072	7	.	.	PUNCT
cusj-5588	1073	1	targeted	target	VERB
cusj-5588	1073	2	delivery	delivery	NOUN
cusj-5588	1073	3	of	of	ADP
cusj-5588	1073	4	nerve	nerve	NOUN
cusj-5588	1073	5	growth	growth	NOUN
cusj-5588	1073	6	factor	factor	NOUN
cusj-5588	1073	7	via	via	ADP
cusj-5588	1073	8	encapsulated	encapsulate	VERB
cusj-5588	1073	9	cell	cell	NOUN
cusj-5588	1073	10	biodelivery	biodelivery	NOUN
cusj-5588	1073	11	in	in	ADP
cusj-5588	1073	12	alzheimer	alzheimer	PROPN
cusj-5588	1073	13	disease	disease	PROPN
cusj-5588	1073	14	:	:	PUNCT
cusj-5588	1073	15	a	a	DET
cusj-5588	1073	16	technology	technology	NOUN
cusj-5588	1073	17	platform	platform	NOUN
cusj-5588	1073	18	for	for	ADP
cusj-5588	1073	19	restorative	restorative	ADJ
cusj-5588	1073	20	neurosurgery	neurosurgery	NOUN
cusj-5588	1073	21	.	.	PUNCT
cusj-5588	1074	1	journal	journal	NOUN
cusj-5588	1074	2	of	of	ADP
cusj-5588	1074	3	neurosurgery	neurosurgery	NOUN
cusj-5588	1074	4	,	,	PUNCT
cusj-5588	1074	5	117(2	117(2	NUM
cusj-5588	1074	6	)	)	PUNCT
cusj-5588	1074	7	,	,	PUNCT
cusj-5588	1074	8	340	340	NUM
cusj-5588	1074	9	-	-	SYM
cusj-5588	1074	10	347	347	NUM
cusj-5588	1074	11	.	.	PUNCT
cusj-5588	1075	1	doi:10.3171/2012.2.jns11714	doi:10.3171/2012.2.jns11714	NOUN
cusj-5588	1075	2	19	19	NUM