id	sid	tid	token	lemma	pos
cusj-6369	1	1	tive	tive	NOUN
cusj-6369	1	2	disorders	disorder	NOUN
cusj-6369	1	3	and	and	CCONJ
cusj-6369	1	4	the	the	DET
cusj-6369	1	5	prevention	prevention	NOUN
cusj-6369	1	6	of	of	ADP
cusj-6369	1	7	stroke	stroke	NOUN
cusj-6369	1	8	(	(	PUNCT
cusj-6369	1	9	chiaradonna	chiaradonna	PROPN
cusj-6369	1	10	,	,	PUNCT
cusj-6369	1	11	2012	2012	NUM
cusj-6369	1	12	;	;	PUNCT
cusj-6369	1	13	huang	huang	PROPN
cusj-6369	1	14	et	et	PROPN
cusj-6369	1	15	al	al	PROPN
cusj-6369	1	16	.	.	PROPN
cusj-6369	1	17	,	,	PUNCT
cusj-6369	1	18	2011	2011	NUM
cusj-6369	1	19	;	;	PUNCT
cusj-6369	1	20	dhawan	dhawan	PROPN
cusj-6369	1	21	et	et	PROPN
cusj-6369	1	22	al	al	PROPN
cusj-6369	1	23	.	.	PROPN
cusj-6369	1	24	,	,	PUNCT
cusj-6369	1	25	2011	2011	NUM
cusj-6369	1	26	)	)	PUNCT
cusj-6369	1	27	.	.	PUNCT
cusj-6369	2	1	currently	currently	ADV
cusj-6369	2	2	,	,	PUNCT
cusj-6369	2	3	there	there	PRON
cusj-6369	2	4	are	be	VERB
cusj-6369	2	5	only	only	ADV
cusj-6369	2	6	two	two	NUM
cusj-6369	2	7	known	know	VERB
cusj-6369	2	8	glutaminase	glutaminase	NOUN
cusj-6369	2	9	inhibitors	inhibitor	NOUN
cusj-6369	2	10	:	:	PUNCT
cusj-6369	2	11	bis-2-(5	bis-2-(5	NOUN
cusj-6369	2	12	-	-	PUNCT
cusj-6369	2	13	phenylacetamido-1,2,4	phenylacetamido-1,2,4	NOUN
cusj-6369	2	14	-	-	PUNCT
cusj-6369	2	15	thiadiazol-2	thiadiazol-2	NUM
cusj-6369	2	16	-	-	PUNCT
cusj-6369	2	17	yl)ethylsul!de	yl)ethylsul!de	NOUN
cusj-6369	2	18	(	(	PUNCT
cusj-6369	2	19	bptes	bptes	PROPN
cusj-6369	2	20	)	)	PUNCT
cusj-6369	2	21	and	and	CCONJ
cusj-6369	2	22	6	6	NUM
cusj-6369	2	23	-	-	PUNCT
cusj-6369	2	24	diazo-5	diazo-5	NUM
cusj-6369	2	25	-	-	PUNCT
cusj-6369	2	26	oxo	oxo	VERB
cusj-6369	2	27	-	-	PUNCT
cusj-6369	2	28	l	l	NOUN
cusj-6369	2	29	-	-	NOUN
cusj-6369	2	30	norleucine	norleucine	NOUN
cusj-6369	2	31	(	(	PUNCT
cusj-6369	2	32	don	don	PROPN
cusj-6369	2	33	)	)	PUNCT
cusj-6369	2	34	(	(	PUNCT
cusj-6369	2	35	hartwick	hartwick	NOUN
cusj-6369	2	36	,	,	PUNCT
cusj-6369	2	37	2011	2011	NUM
cusj-6369	2	38	)	)	PUNCT
cusj-6369	2	39	.	.	PUNCT
cusj-6369	3	1	however	however	ADV
cusj-6369	3	2	,	,	PUNCT
cusj-6369	3	3	neither	neither	CCONJ
cusj-6369	3	4	compound	compound	NOUN
cusj-6369	3	5	crosses	cross	VERB
cusj-6369	3	6	the	the	DET
cusj-6369	3	7	blood	blood	NOUN
cusj-6369	3	8	-	-	PUNCT
cusj-6369	3	9	brain	brain	NOUN
cusj-6369	3	10	barrier	barrier	NOUN
cusj-6369	3	11	nor	nor	CCONJ
cusj-6369	3	12	is	be	AUX
cusj-6369	3	13	neuroactive	neuroactive	ADJ
cusj-6369	3	14	;	;	PUNCT
cusj-6369	3	15	thus	thus	ADV
cusj-6369	3	16	,	,	PUNCT
cusj-6369	3	17	neither	neither	PRON
cusj-6369	3	18	is	be	AUX
cusj-6369	3	19	suitable	suitable	ADJ
cusj-6369	3	20	for	for	ADP
cusj-6369	3	21	pharmacotherapy	pharmacotherapy	NOUN
cusj-6369	3	22	of	of	ADP
cusj-6369	3	23	schizophrenia	schizophrenia	NOUN
cusj-6369	3	24	.	.	PUNCT
cusj-6369	4	1	"	"	PUNCT
cusj-6369	4	2	e	e	X
cusj-6369	4	3	purpose	purpose	NOUN
cusj-6369	4	4	of	of	ADP
cusj-6369	4	5	this	this	DET
cusj-6369	4	6	study	study	NOUN
cusj-6369	4	7	was	be	AUX
cusj-6369	4	8	to	to	PART
cusj-6369	4	9	screen	screen	VERB
cusj-6369	4	10	for	for	ADP
cusj-6369	4	11	pag	pag	PROPN
cusj-6369	4	12	inhibitors	inhibitor	NOUN
cusj-6369	4	13	in	in	ADP
cusj-6369	4	14	a	a	DET
cusj-6369	4	15	library	library	NOUN
cusj-6369	4	16	of	of	ADP
cusj-6369	4	17	58,000	58,000	NUM
cusj-6369	4	18	neuroactive	neuroactive	ADJ
cusj-6369	4	19	compounds	compound	NOUN
cusj-6369	4	20	.	.	PUNCT
cusj-6369	5	1	robotic	robotic	ADJ
cusj-6369	5	2	processing	processing	NOUN
cusj-6369	5	3	with	with	ADP
cusj-6369	5	4	a	a	DET
cusj-6369	5	5	#	#	SYM
cusj-6369	5	6	uorescence	uorescence	NOUN
cusj-6369	5	7	-	-	PUNCT
cusj-6369	5	8	based	base	VERB
cusj-6369	5	9	assay	assay	NOUN
cusj-6369	5	10	was	be	AUX
cusj-6369	5	11	used	use	VERB
cusj-6369	5	12	to	to	PART
cusj-6369	5	13	assess	assess	VERB
cusj-6369	5	14	inhibition	inhibition	NOUN
cusj-6369	5	15	of	of	ADP
cusj-6369	5	16	pag	pag	NOUN
cusj-6369	5	17	activity	activity	NOUN
cusj-6369	5	18	in	in	ADP
cusj-6369	5	19	vitro	vitro	X
cusj-6369	5	20	.	.	PUNCT
cusj-6369	6	1	a	a	DET
cusj-6369	6	2	secondary	secondary	ADJ
cusj-6369	6	3	assay	assay	NOUN
cusj-6369	6	4	was	be	AUX
cusj-6369	6	5	used	use	VERB
cusj-6369	6	6	to	to	ADP
cusj-6369	6	7	con!rm	con!rm	PROPN
cusj-6369	6	8	pag	pag	NOUN
cusj-6369	6	9	-	-	PUNCT
cusj-6369	6	10	speci!city	speci!city	NOUN
cusj-6369	6	11	of	of	ADP
cusj-6369	6	12	apparent	apparent	ADJ
cusj-6369	6	13	inhibitors	inhibitor	NOUN
cusj-6369	6	14	,	,	PUNCT
cusj-6369	6	15	and	and	CCONJ
cusj-6369	6	16	subsequent	subsequent	ADJ
cusj-6369	6	17	kinetic	kinetic	ADJ
cusj-6369	6	18	analysis	analysis	NOUN
cusj-6369	6	19	of	of	ADP
cusj-6369	6	20	the	the	DET
cusj-6369	6	21	top	top	ADJ
cusj-6369	6	22	tier	tier	NOUN
cusj-6369	6	23	of	of	ADP
cusj-6369	6	24	these	these	DET
cusj-6369	6	25	hits	hit	NOUN
cusj-6369	6	26	was	be	AUX
cusj-6369	6	27	used	use	VERB
cusj-6369	6	28	to	to	PART
cusj-6369	6	29	select	select	VERB
cusj-6369	6	30	two	two	NUM
cusj-6369	6	31	leads	lead	NOUN
cusj-6369	6	32	for	for	ADP
cusj-6369	6	33	further	further	ADJ
cusj-6369	6	34	chemical	chemical	NOUN
cusj-6369	6	35	optimization	optimization	NOUN
cusj-6369	6	36	.	.	PUNCT
cusj-6369	7	1	primary	primary	ADJ
cusj-6369	7	2	screen	screen	NOUN
cusj-6369	7	3	a	a	DET
cusj-6369	7	4	library	library	NOUN
cusj-6369	7	5	of	of	ADP
cusj-6369	7	6	58,000	58,000	NUM
cusj-6369	7	7	neuroactive	neuroactive	ADJ
cusj-6369	7	8	compounds	compound	NOUN
cusj-6369	7	9	was	be	AUX
cusj-6369	7	10	purchased	purchase	VERB
cusj-6369	7	11	from	from	ADP
cusj-6369	7	12	chembridge	chembridge	PROPN
cusj-6369	7	13	.	.	PUNCT
cusj-6369	8	1	compounds	compound	NOUN
cusj-6369	8	2	were	be	AUX
cusj-6369	8	3	supplied	supply	VERB
cusj-6369	8	4	at	at	ADP
cusj-6369	8	5	a	a	DET
cusj-6369	8	6	concentration	concentration	NOUN
cusj-6369	8	7	of	of	ADP
cusj-6369	8	8	10	10	NUM
cusj-6369	8	9	-	-	SYM
cusj-6369	8	10	3	3	NUM
cusj-6369	8	11	m	m	NOUN
cusj-6369	8	12	in	in	ADP
cusj-6369	8	13	dmso	dmso	NOUN
cusj-6369	8	14	and	and	CCONJ
cusj-6369	8	15	were	be	AUX
cusj-6369	8	16	stored	store	VERB
cusj-6369	8	17	in	in	ADP
cusj-6369	8	18	384well	384well	PROPN
cusj-6369	8	19	plates	plate	NOUN
cusj-6369	8	20	at	at	ADP
cusj-6369	8	21	-80oc	-80oc	PROPN
cusj-6369	8	22	.	.	PUNCT
cusj-6369	9	1	human	human	PROPN
cusj-6369	9	2	pag	pag	PROPN
cusj-6369	9	3	was	be	AUX
cusj-6369	9	4	synthesized	synthesize	VERB
cusj-6369	9	5	and	and	CCONJ
cusj-6369	9	6	puri!ed	puri!e	VERB
cusj-6369	9	7	by	by	ADP
cusj-6369	9	8	our	our	PRON
cusj-6369	9	9	lab	lab	NOUN
cusj-6369	9	10	using	use	VERB
cusj-6369	9	11	a	a	DET
cusj-6369	9	12	plasmid	plasmid	NOUN
cusj-6369	9	13	provided	provide	VERB
cusj-6369	9	14	by	by	ADP
cusj-6369	9	15	professor	professor	PROPN
cusj-6369	9	16	norman	norman	PROPN
cusj-6369	9	17	curthoys	curthoys	PROPN
cusj-6369	9	18	(	(	PUNCT
cusj-6369	9	19	colorado	colorado	PROPN
cusj-6369	9	20	state	state	PROPN
cusj-6369	9	21	university	university	PROPN
cusj-6369	9	22	)	)	PUNCT
cusj-6369	9	23	as	as	SCONJ
cusj-6369	9	24	previously	previously	ADV
cusj-6369	9	25	described	describe	VERB
cusj-6369	9	26	in	in	ADP
cusj-6369	9	27	kenny	kenny	PROPN
cusj-6369	9	28	et	et	PROPN
cusj-6369	9	29	al	al	PROPN
cusj-6369	9	30	.	.	PROPN
cusj-6369	10	1	(	(	PUNCT
cusj-6369	10	2	2003	2003	NUM
cusj-6369	10	3	)	)	PUNCT
cusj-6369	10	4	.	.	PUNCT
cusj-6369	11	1	"	"	PUNCT
cusj-6369	11	2	e	e	X
cusj-6369	11	3	#	#	SYM
cusj-6369	11	4	uorescence	uorescence	NOUN
cusj-6369	11	5	assay	assay	NOUN
cusj-6369	11	6	used	use	VERB
cusj-6369	11	7	for	for	ADP
cusj-6369	11	8	the	the	DET
cusj-6369	11	9	screen	screen	NOUN
cusj-6369	11	10	was	be	AUX
cusj-6369	11	11	optimized	optimize	VERB
cusj-6369	11	12	from	from	ADP
cusj-6369	11	13	a	a	DET
cusj-6369	11	14	commercially	commercially	ADV
cusj-6369	11	15	available	available	ADJ
cusj-6369	11	16	kit	kit	NOUN
cusj-6369	11	17	(	(	PUNCT
cusj-6369	11	18	amplex	amplex	NOUN
cusj-6369	11	19	red	red	PROPN
cusj-6369	11	20	,	,	PUNCT
cusj-6369	11	21	invitrogen	invitrogen	PROPN
cusj-6369	11	22	)	)	PUNCT
cusj-6369	11	23	and	and	CCONJ
cusj-6369	11	24	was	be	AUX
cusj-6369	11	25	used	use	VERB
cusj-6369	11	26	to	to	PART
cusj-6369	11	27	measure	measure	VERB
cusj-6369	11	28	pag	pag	PROPN
cusj-6369	11	29	activity	activity	NOUN
cusj-6369	11	30	in	in	ADP
cusj-6369	11	31	the	the	DET
cusj-6369	11	32	presence	presence	NOUN
cusj-6369	11	33	of	of	ADP
cusj-6369	11	34	each	each	DET
cusj-6369	11	35	library	library	NOUN
cusj-6369	11	36	compound	compound	NOUN
cusj-6369	11	37	.	.	PUNCT
cusj-6369	12	1	glutamate	glutamate	NOUN
cusj-6369	12	2	,	,	PUNCT
cusj-6369	12	3	the	the	DET
cusj-6369	12	4	product	product	NOUN
cusj-6369	12	5	of	of	ADP
cusj-6369	12	6	pag	pag	PROPN
cusj-6369	12	7	catalysis	catalysis	NOUN
cusj-6369	12	8	,	,	PUNCT
cusj-6369	12	9	was	be	AUX
cusj-6369	12	10	converted	convert	VERB
cusj-6369	12	11	to	to	ADP
cusj-6369	12	12	a	a	DET
cusj-6369	12	13	#	#	NOUN
cusj-6369	12	14	uorescent	uorescent	ADJ
cusj-6369	12	15	compound	compound	NOUN
cusj-6369	12	16	called	call	VERB
cusj-6369	12	17	resoru!n	resoru!n	PROPN
cusj-6369	12	18	by	by	ADP
cusj-6369	12	19	the	the	DET
cusj-6369	12	20	addition	addition	NOUN
cusj-6369	12	21	of	of	ADP
cusj-6369	12	22	a	a	DET
cusj-6369	12	23	series	series	NOUN
cusj-6369	12	24	of	of	ADP
cusj-6369	12	25	kit	kit	NOUN
cusj-6369	12	26	enzymes	enzyme	NOUN
cusj-6369	12	27	,	,	PUNCT
cusj-6369	12	28	including	include	VERB
cusj-6369	12	29	glutamate	glutamate	NOUN
cusj-6369	12	30	oxidase	oxidase	NOUN
cusj-6369	12	31	(	(	PUNCT
cusj-6369	12	32	go	go	NOUN
cusj-6369	12	33	)	)	PUNCT
cusj-6369	12	34	,	,	PUNCT
cusj-6369	12	35	horseradish	horseradish	ADJ
cusj-6369	12	36	peroxidase	peroxidase	NOUN
cusj-6369	12	37	(	(	PUNCT
cusj-6369	12	38	hrp	hrp	PROPN
cusj-6369	12	39	)	)	PUNCT
cusj-6369	12	40	,	,	PUNCT
cusj-6369	12	41	and	and	CCONJ
cusj-6369	12	42	the	the	DET
cusj-6369	12	43	#	#	ADV
cusj-6369	12	44	uorogenic	uorogenic	ADJ
cusj-6369	12	45	substrate	substrate	NOUN
cusj-6369	12	46	amplex	amplex	NOUN
cusj-6369	12	47	red	red	NOUN
cusj-6369	12	48	(	(	PUNCT
cusj-6369	12	49	figure	figure	NOUN
cusj-6369	12	50	1	1	NUM
cusj-6369	12	51	)	)	PUNCT
cusj-6369	12	52	.	.	PUNCT
cusj-6369	13	1	because	because	SCONJ
cusj-6369	13	2	the	the	DET
cusj-6369	13	3	#	#	NOUN
cusj-6369	13	4	uorescent	uorescent	ADJ
cusj-6369	13	5	molecule	molecule	NOUN
cusj-6369	13	6	resoru!n	resoru!n	PROPN
cusj-6369	13	7	is	be	AUX
cusj-6369	13	8	dependent	dependent	ADJ
cusj-6369	13	9	on	on	ADP
cusj-6369	13	10	glutamate	glutamate	ADJ
cusj-6369	13	11	production	production	NOUN
cusj-6369	13	12	and	and	CCONJ
cusj-6369	13	13	glutamate	glutamate	NOUN
cusj-6369	13	14	production	production	NOUN
cusj-6369	13	15	is	be	AUX
cusj-6369	13	16	the	the	DET
cusj-6369	13	17	product	product	NOUN
cusj-6369	13	18	of	of	ADP
cusj-6369	13	19	pag	pag	PROPN
cusj-6369	13	20	catalysis	catalysis	NOUN
cusj-6369	13	21	,	,	PUNCT
cusj-6369	13	22	the	the	DET
cusj-6369	13	23	rate	rate	NOUN
cusj-6369	13	24	of	of	ADP
cusj-6369	13	25	change	change	NOUN
cusj-6369	13	26	in	in	ADP
cusj-6369	13	27	#	#	SYM
cusj-6369	13	28	uorescence	uorescence	NOUN
cusj-6369	13	29	is	be	AUX
cusj-6369	13	30	a	a	DET
cusj-6369	13	31	measurement	measurement	NOUN
cusj-6369	13	32	of	of	ADP
cusj-6369	13	33	pag	pag	PROPN
cusj-6369	13	34	activity	activity	NOUN
cusj-6369	13	35	.	.	PUNCT
cusj-6369	14	1	potent	potent	ADJ
cusj-6369	14	2	inhibitors	inhibitor	NOUN
cusj-6369	14	3	of	of	ADP
cusj-6369	14	4	pag	pag	PROPN
cusj-6369	14	5	would	would	AUX
cusj-6369	14	6	signi!cantly	signi!cantly	ADV
cusj-6369	14	7	decrease	decrease	VERB
cusj-6369	14	8	the	the	DET
cusj-6369	14	9	#	#	SYM
cusj-6369	14	10	uorescence	uorescence	NOUN
cusj-6369	14	11	compared	compare	VERB
cusj-6369	14	12	to	to	ADP
cusj-6369	14	13	controls	control	NOUN
cusj-6369	14	14	without	without	ADP
cusj-6369	14	15	inhibitor	inhibitor	NOUN
cusj-6369	14	16	.	.	PUNCT
cusj-6369	15	1	"	"	PUNCT
cusj-6369	15	2	e	e	X
cusj-6369	15	3	assay	assay	NOUN
cusj-6369	15	4	was	be	AUX
cusj-6369	15	5	carried	carry	VERB
cusj-6369	15	6	out	out	ADP
cusj-6369	15	7	in	in	ADP
cusj-6369	15	8	a	a	DET
cusj-6369	15	9	384	384	NUM
cusj-6369	15	10	-	-	PUNCT
cusj-6369	15	11	well	well	ADJ
cusj-6369	15	12	plate	plate	NOUN
cusj-6369	15	13	,	,	PUNCT
cusj-6369	15	14	with	with	ADP
cusj-6369	15	15	80	80	NUM
cusj-6369	15	16	µl	µl	NOUN
cusj-6369	15	17	of	of	ADP
cusj-6369	15	18	total	total	ADJ
cusj-6369	15	19	liquid	liquid	ADJ
cusj-6369	15	20	volume	volume	NOUN
cusj-6369	15	21	per	per	ADP
cusj-6369	15	22	well	well	ADV
cusj-6369	15	23	.	.	PUNCT
cusj-6369	16	1	320	320	NUM
cusj-6369	16	2	wells	well	NOUN
cusj-6369	16	3	were	be	AUX
cusj-6369	16	4	carried	carry	VERB
cusj-6369	16	5	out	out	ADP
cusj-6369	16	6	under	under	ADP
cusj-6369	16	7	experimental	experimental	ADJ
cusj-6369	16	8	conditions	condition	NOUN
cusj-6369	16	9	,	,	PUNCT
cusj-6369	16	10	where	where	SCONJ
cusj-6369	16	11	20	20	NUM
cusj-6369	16	12	µl	µl	NOUN
cusj-6369	16	13	of	of	ADP
cusj-6369	16	14	amplex	amplex	ADJ
cusj-6369	16	15	red	red	ADJ
cusj-6369	16	16	solution	solution	NOUN
cusj-6369	16	17	(	(	PUNCT
cusj-6369	16	18	itself	itself	PRON
cusj-6369	16	19	containing	contain	VERB
cusj-6369	16	20	8	8	NUM
cusj-6369	16	21	ml	ml	NOUN
cusj-6369	16	22	of	of	ADP
cusj-6369	16	23	tris	tris	ADJ
cusj-6369	16	24	-	-	PUNCT
cusj-6369	16	25	hcl	hcl	PROPN
cusj-6369	16	26	reaction	reaction	NOUN
cusj-6369	16	27	bu$er	bu$er	PROPN
cusj-6369	16	28	,	,	PUNCT
cusj-6369	16	29	60	60	NUM
cusj-6369	16	30	µl	µl	NOUN
cusj-6369	16	31	of	of	ADP
cusj-6369	16	32	go	go	VERB
cusj-6369	16	33	,	,	PUNCT
cusj-6369	16	34	25	25	NUM
cusj-6369	16	35	µl	µl	NOUN
cusj-6369	16	36	of	of	ADP
cusj-6369	16	37	hrp	hrp	PROPN
cusj-6369	16	38	,	,	PUNCT
cusj-6369	16	39	and	and	CCONJ
cusj-6369	16	40	80	80	NUM
cusj-6369	16	41	µl	µl	NOUN
cusj-6369	16	42	of	of	ADP
cusj-6369	16	43	amplex	amplex	ADJ
cusj-6369	16	44	red	red	ADJ
cusj-6369	16	45	reagent	reagent	NOUN
cusj-6369	16	46	)	)	PUNCT
cusj-6369	16	47	,	,	PUNCT
cusj-6369	16	48	40	40	NUM
cusj-6369	16	49	µl	µl	NOUN
cusj-6369	16	50	of	of	ADP
cusj-6369	16	51	pag	pag	PROPN
cusj-6369	16	52	solution	solution	NOUN
cusj-6369	16	53	(	(	PUNCT
cusj-6369	16	54	itself	itself	PRON
cusj-6369	16	55	2	2	NUM
cusj-6369	16	56	µl	µl	ADP
cusj-6369	16	57	of	of	ADP
cusj-6369	16	58	synthesized	synthesize	VERB
cusj-6369	16	59	pag	pag	NOUN
cusj-6369	16	60	in	in	ADP
cusj-6369	16	61	32	32	NUM
cusj-6369	16	62	ml	ml	NOUN
cusj-6369	16	63	of	of	ADP
cusj-6369	16	64	tris	tris	ADJ
cusj-6369	16	65	-	-	PUNCT
cusj-6369	16	66	phosphate	phosphate	NOUN
cusj-6369	16	67	bu$er	bu$er	NOUN
cusj-6369	16	68	)	)	PUNCT
cusj-6369	16	69	,	,	PUNCT
cusj-6369	16	70	0.8	0.8	NUM
cusj-6369	16	71	µl	µl	NOUN
cusj-6369	16	72	of	of	ADP
cusj-6369	16	73	one	one	NUM
cusj-6369	16	74	library	library	NOUN
cusj-6369	16	75	compound	compound	NOUN
cusj-6369	16	76	(	(	PUNCT
cusj-6369	16	77	originally	originally	ADV
cusj-6369	16	78	10	10	NUM
cusj-6369	16	79	-	-	SYM
cusj-6369	16	80	3	3	NUM
cusj-6369	16	81	m	m	NOUN
cusj-6369	16	82	,	,	PUNCT
cusj-6369	16	83	but	but	CCONJ
cusj-6369	16	84	diluted	dilute	VERB
cusj-6369	16	85	to	to	ADP
cusj-6369	16	86	10	10	NUM
cusj-6369	16	87	-	-	SYM
cusj-6369	16	88	4	4	NUM
cusj-6369	16	89	m	m	NOUN
cusj-6369	16	90	in	in	ADP
cusj-6369	16	91	well	well	ADV
cusj-6369	16	92	)	)	PUNCT
cusj-6369	16	93	,	,	PUNCT
cusj-6369	16	94	and	and	CCONJ
cusj-6369	16	95	20	20	NUM
cusj-6369	16	96	µl	µl	NOUN
cusj-6369	16	97	of	of	ADP
cusj-6369	16	98	40	40	NUM
cusj-6369	16	99	µm	µm	NOUN
cusj-6369	16	100	glutamine	glutamine	NOUN
cusj-6369	16	101	solution	solution	NOUN
cusj-6369	16	102	were	be	AUX
cusj-6369	16	103	pipetted	pipette	VERB
cusj-6369	16	104	into	into	ADP
cusj-6369	16	105	each	each	DET
cusj-6369	16	106	well	well	NOUN
cusj-6369	16	107	.	.	PUNCT
cusj-6369	17	1	while	while	SCONJ
cusj-6369	17	2	kit	kit	ADJ
cusj-6369	17	3	enzyme	enzyme	NOUN
cusj-6369	17	4	concentrations	concentration	NOUN
cusj-6369	17	5	were	be	AUX
cusj-6369	17	6	the	the	DET
cusj-6369	17	7	same	same	ADJ
cusj-6369	17	8	as	as	ADP
cusj-6369	17	9	those	those	PRON
cusj-6369	17	10	used	use	VERB
cusj-6369	17	11	in	in	ADP
cusj-6369	17	12	the	the	DET
cusj-6369	17	13	amplex	amplex	ADJ
cusj-6369	17	14	red	red	ADJ
cusj-6369	17	15	kit	kit	NOUN
cusj-6369	17	16	protocol	protocol	NOUN
cusj-6369	17	17	(	(	PUNCT
cusj-6369	17	18	so	so	SCONJ
cusj-6369	17	19	that	that	SCONJ
cusj-6369	17	20	all	all	DET
cusj-6369	17	21	kit	kit	NOUN
cusj-6369	17	22	enzymes	enzyme	NOUN
cusj-6369	17	23	were	be	AUX
cusj-6369	17	24	in	in	ADP
cusj-6369	17	25	excess	excess	ADJ
cusj-6369	17	26	)	)	PUNCT
cusj-6369	17	27	,	,	PUNCT
cusj-6369	17	28	optimum	optimum	ADJ
cusj-6369	17	29	glutamine	glutamine	NOUN
cusj-6369	17	30	and	and	CCONJ
cusj-6369	17	31	pag	pag	PROPN
cusj-6369	17	32	concentrations	concentration	NOUN
cusj-6369	17	33	were	be	AUX
cusj-6369	17	34	determined	determine	VERB
cusj-6369	17	35	according	accord	VERB
cusj-6369	17	36	to	to	ADP
cusj-6369	17	37	michaelis	michaelis	ADJ
cusj-6369	17	38	-	-	PUNCT
cusj-6369	17	39	menten	menten	ADJ
cusj-6369	17	40	kinetics	kinetic	NOUN
cusj-6369	17	41	.	.	PUNCT
cusj-6369	18	1	"	"	PUNCT
cusj-6369	18	2	e	e	X
cusj-6369	18	3	concentration	concentration	NOUN
cusj-6369	18	4	of	of	ADP
cusj-6369	18	5	glutamine	glutamine	NOUN
cusj-6369	18	6	was	be	AUX
cusj-6369	18	7	selected	select	VERB
cusj-6369	18	8	based	base	VERB
cusj-6369	18	9	on	on	ADP
cusj-6369	18	10	the	the	DET
cusj-6369	18	11	previously	previously	ADV
cusj-6369	18	12	determined	determine	VERB
cusj-6369	18	13	value	value	NOUN
cusj-6369	18	14	of	of	ADP
cusj-6369	18	15	the	the	DET
cusj-6369	18	16	km	km	NOUN
cusj-6369	18	17	of	of	ADP
cusj-6369	18	18	pag	pag	PROPN
cusj-6369	18	19	-	-	PUNCT
cusj-6369	18	20	catalyzed	catalyze	VERB
cusj-6369	18	21	glutamine	glutamine	NOUN
cusj-6369	18	22	deamination	deamination	NOUN
cusj-6369	18	23	.	.	PUNCT
cusj-6369	19	1	km	km	PROPN
cusj-6369	19	2	is	be	AUX
cusj-6369	19	3	de!ned	de!ne	VERB
cusj-6369	19	4	as	as	ADP
cusj-6369	19	5	the	the	DET
cusj-6369	19	6	concentration	concentration	NOUN
cusj-6369	19	7	of	of	ADP
cusj-6369	19	8	substrate	substrate	NOUN
cusj-6369	19	9	(	(	PUNCT
cusj-6369	19	10	glutamine	glutamine	NOUN
cusj-6369	19	11	)	)	PUNCT
cusj-6369	19	12	required	require	VERB
cusj-6369	19	13	to	to	PART
cusj-6369	19	14	reach	reach	VERB
cusj-6369	19	15	one	one	NUM
cusj-6369	19	16	half	half	NOUN
cusj-6369	19	17	of	of	ADP
cusj-6369	19	18	the	the	DET
cusj-6369	19	19	maximal	maximal	ADJ
cusj-6369	19	20	reaction	reaction	NOUN
cusj-6369	19	21	velocity	velocity	NOUN
cusj-6369	19	22	(	(	PUNCT
cusj-6369	19	23	vmax	vmax	PROPN
cusj-6369	19	24	)	)	PUNCT
cusj-6369	19	25	for	for	ADP
cusj-6369	19	26	a	a	DET
cusj-6369	19	27	particular	particular	ADJ
cusj-6369	19	28	enzyme	enzyme	NOUN
cusj-6369	19	29	-	-	PUNCT
cusj-6369	19	30	catalyzed	catalyze	VERB
cusj-6369	19	31	reaction	reaction	NOUN
cusj-6369	19	32	(	(	PUNCT
cusj-6369	19	33	copeland	copeland	PROPN
cusj-6369	19	34	,	,	PUNCT
cusj-6369	19	35	2000	2000	NUM
cusj-6369	19	36	)	)	PUNCT
cusj-6369	19	37	.	.	PUNCT
cusj-6369	20	1	control	control	NOUN
cusj-6369	20	2	conditions	condition	NOUN
cusj-6369	20	3	were	be	AUX
cusj-6369	20	4	included	include	VERB
cusj-6369	20	5	in	in	ADP
cusj-6369	20	6	the	the	DET
cusj-6369	20	7	remaining	remain	VERB
cusj-6369	20	8	64	64	NUM
cusj-6369	20	9	wells	well	NOUN
cusj-6369	20	10	of	of	ADP
cusj-6369	20	11	each	each	DET
cusj-6369	20	12	plate	plate	NOUN
cusj-6369	20	13	.	.	PUNCT
cusj-6369	21	1	positive	positive	ADJ
cusj-6369	21	2	control	control	NOUN
cusj-6369	21	3	wells	wells	PROPN
cusj-6369	21	4	,	,	PUNCT
cusj-6369	21	5	representing	represent	VERB
cusj-6369	21	6	100	100	NUM
cusj-6369	21	7	%	%	NOUN
cusj-6369	21	8	pag	pag	NOUN
cusj-6369	21	9	activity	activity	NOUN
cusj-6369	21	10	(	(	PUNCT
cusj-6369	21	11	0	0	NUM
cusj-6369	21	12	%	%	NOUN
cusj-6369	21	13	pag	pag	NOUN
cusj-6369	21	14	inhibition	inhibition	NOUN
cusj-6369	21	15	)	)	PUNCT
cusj-6369	21	16	,	,	PUNCT
cusj-6369	21	17	contained	contain	VERB
cusj-6369	21	18	pag	pag	PROPN
cusj-6369	21	19	,	,	PUNCT
cusj-6369	21	20	glutamine	glutamine	NOUN
cusj-6369	21	21	,	,	PUNCT
cusj-6369	21	22	and	and	CCONJ
cusj-6369	21	23	amplex	amplex	ADJ
cusj-6369	21	24	red	red	ADJ
cusj-6369	21	25	solution	solution	NOUN
cusj-6369	21	26	.	.	PUNCT
cusj-6369	22	1	negative	negative	ADJ
cusj-6369	22	2	control	control	PROPN
cusj-6369	22	3	wells	well	NOUN
cusj-6369	22	4	,	,	PUNCT
cusj-6369	22	5	representing	represent	VERB
cusj-6369	22	6	0	0	NUM
cusj-6369	22	7	%	%	NOUN
cusj-6369	22	8	pag	pag	NOUN
cusj-6369	22	9	activity	activity	NOUN
cusj-6369	22	10	(	(	PUNCT
cusj-6369	22	11	100	100	NUM
cusj-6369	22	12	%	%	NOUN
cusj-6369	22	13	inhibition	inhibition	NOUN
cusj-6369	22	14	)	)	PUNCT
cusj-6369	22	15	,	,	PUNCT
cusj-6369	22	16	contained	contain	VERB
cusj-6369	22	17	glutamine	glutamine	NOUN
cusj-6369	22	18	and	and	CCONJ
cusj-6369	22	19	amplex	amplex	ADJ
cusj-6369	22	20	red	red	ADJ
cusj-6369	22	21	solution	solution	NOUN
cusj-6369	22	22	.	.	PUNCT
cusj-6369	23	1	75	75	NUM
cusj-6369	23	2	%	%	NOUN
cusj-6369	23	3	,	,	PUNCT
cusj-6369	23	4	50	50	NUM
cusj-6369	23	5	%	%	NOUN
cusj-6369	23	6	,	,	PUNCT
cusj-6369	23	7	and	and	CCONJ
cusj-6369	23	8	25	25	NUM
cusj-6369	23	9	%	%	NOUN
cusj-6369	23	10	inhibition	inhibition	NOUN
cusj-6369	23	11	controls	control	NOUN
cusj-6369	23	12	were	be	AUX
cusj-6369	23	13	also	also	ADV
cusj-6369	23	14	used	use	VERB
cusj-6369	23	15	,	,	PUNCT
cusj-6369	23	16	obtained	obtain	VERB
cusj-6369	23	17	by	by	ADP
cusj-6369	23	18	creating	create	VERB
cusj-6369	23	19	a	a	DET
cusj-6369	23	20	dilution	dilution	NOUN
cusj-6369	23	21	series	series	NOUN
cusj-6369	23	22	of	of	ADP
cusj-6369	23	23	the	the	DET
cusj-6369	23	24	positive	positive	ADJ
cusj-6369	23	25	control	control	NOUN
cusj-6369	23	26	.	.	PUNCT
cusj-6369	24	1	additionally	additionally	ADV
cusj-6369	24	2	,	,	PUNCT
cusj-6369	24	3	amplex	amplex	ADJ
cusj-6369	24	4	red	red	ADJ
cusj-6369	24	5	solution	solution	NOUN
cusj-6369	24	6	only	only	ADV
cusj-6369	24	7	controls	control	NOUN
cusj-6369	24	8	were	be	AUX
cusj-6369	24	9	used	use	VERB
cusj-6369	24	10	as	as	ADP
cusj-6369	24	11	an	an	DET
cusj-6369	24	12	additional	additional	ADJ
cusj-6369	24	13	negative	negative	ADJ
cusj-6369	24	14	control	control	NOUN
cusj-6369	24	15	.	.	PUNCT
cusj-6369	25	1	in	in	ADP
cusj-6369	25	2	control	control	PROPN
cusj-6369	25	3	wells	wells	PROPN
cusj-6369	25	4	,	,	PUNCT
cusj-6369	25	5	where	where	SCONJ
cusj-6369	25	6	necessary	necessary	ADJ
cusj-6369	25	7	,	,	PUNCT
cusj-6369	25	8	tris	tris	ADJ
cusj-6369	25	9	-	-	PUNCT
cusj-6369	25	10	hcl	hcl	PROPN
cusj-6369	25	11	reaction	reaction	NOUN
cusj-6369	25	12	bu$er	bu$er	PROPN
cusj-6369	25	13	was	be	AUX
cusj-6369	25	14	added	add	VERB
cusj-6369	25	15	to	to	PART
cusj-6369	25	16	bring	bring	VERB
cusj-6369	25	17	wells	well	NOUN
cusj-6369	25	18	to	to	ADP
cusj-6369	25	19	the	the	DET
cusj-6369	25	20	standard	standard	ADJ
cusj-6369	25	21	volume	volume	NOUN
cusj-6369	25	22	.	.	PUNCT
cusj-6369	26	1	outlined	outline	VERB
cusj-6369	26	2	in	in	ADP
cusj-6369	26	3	figure	figure	NOUN
cusj-6369	26	4	2	2	NUM
cusj-6369	26	5	below	below	ADV
cusj-6369	26	6	is	be	AUX
cusj-6369	26	7	a	a	DET
cusj-6369	26	8	typical	typical	ADJ
cusj-6369	26	9	assay	assay	NOUN
cusj-6369	26	10	plate	plate	NOUN
cusj-6369	26	11	setup	setup	NOUN
cusj-6369	26	12	.	.	PUNCT
cusj-6369	27	1	fluorescence	fluorescence	ADJ
cusj-6369	27	2	measurements	measurement	NOUN
cusj-6369	27	3	were	be	AUX
cusj-6369	27	4	taken	take	VERB
cusj-6369	27	5	at	at	ADP
cusj-6369	27	6	baseline	baseline	NOUN
cusj-6369	27	7	(	(	PUNCT
cusj-6369	27	8	immediately	immediately	ADV
cusj-6369	27	9	after	after	SCONJ
cusj-6369	27	10	glutamine	glutamine	NOUN
cusj-6369	27	11	was	be	AUX
cusj-6369	27	12	added	add	VERB
cusj-6369	27	13	to	to	ADP
cusj-6369	27	14	each	each	DET
cusj-6369	27	15	well	well	NOUN
cusj-6369	27	16	)	)	PUNCT
cusj-6369	27	17	,	,	PUNCT
cusj-6369	27	18	and	and	CCONJ
cusj-6369	27	19	after	after	ADP
cusj-6369	27	20	a	a	DET
cusj-6369	27	21	60	60	NUM
cusj-6369	27	22	-	-	PUNCT
cusj-6369	27	23	minute	minute	NOUN
cusj-6369	27	24	incubation	incubation	NOUN
cusj-6369	27	25	at	at	ADP
cusj-6369	27	26	37	37	NUM
cusj-6369	27	27	oc	oc	NOUN
cusj-6369	27	28	,	,	PUNCT
cusj-6369	27	29	by	by	ADP
cusj-6369	27	30	an	an	DET
cusj-6369	27	31	envision	envision	NOUN
cusj-6369	27	32	#	#	SYM
cusj-6369	27	33	uorescence	uorescence	NOUN
cusj-6369	27	34	reader	reader	NOUN
cusj-6369	27	35	(	(	PUNCT
cusj-6369	27	36	perkin	perkin	PROPN
cusj-6369	27	37	elmer	elmer	PROPN
cusj-6369	27	38	)	)	PUNCT
cusj-6369	27	39	.	.	PUNCT
cusj-6369	28	1	pipetting	pipetting	NOUN
cusj-6369	28	2	was	be	AUX
cusj-6369	28	3	done	do	VERB
cusj-6369	28	4	by	by	ADP
cusj-6369	28	5	a	a	DET
cusj-6369	28	6	minitrak	minitrak	NOUN
cusj-6369	28	7	robotic	robotic	ADJ
cusj-6369	28	8	liquid	liquid	NOUN
cusj-6369	28	9	handling	handling	NOUN
cusj-6369	28	10	system	system	NOUN
cusj-6369	28	11	(	(	PUNCT
cusj-6369	28	12	perkin	perkin	PROPN
cusj-6369	28	13	elmer	elmer	PROPN
cusj-6369	28	14	)	)	PUNCT
cusj-6369	28	15	for	for	ADP
cusj-6369	28	16	speed	speed	NOUN
cusj-6369	28	17	and	and	CCONJ
cusj-6369	28	18	e%ciency	e%ciency	PROPN
cusj-6369	28	19	.	.	PUNCT
cusj-6369	29	1	to	to	PART
cusj-6369	29	2	calculate	calculate	VERB
cusj-6369	29	3	percent	percent	NOUN
cusj-6369	29	4	inhibition	inhibition	NOUN
cusj-6369	29	5	of	of	ADP
cusj-6369	29	6	pag	pag	PROPN
cusj-6369	29	7	,	,	PUNCT
cusj-6369	29	8	go	go	VERB
cusj-6369	29	9	,	,	PUNCT
cusj-6369	29	10	and	and	CCONJ
cusj-6369	29	11	hrp	hrp	PROPN
cusj-6369	29	12	,	,	PUNCT
cusj-6369	29	13	the	the	DET
cusj-6369	29	14	average	average	ADJ
cusj-6369	29	15	negative	negative	ADJ
cusj-6369	29	16	control	control	NOUN
cusj-6369	29	17	#	#	NOUN
cusj-6369	29	18	uorescence	uorescence	NOUN
cusj-6369	29	19	was	be	AUX
cusj-6369	29	20	subtracted	subtract	VERB
cusj-6369	29	21	from	from	ADP
cusj-6369	29	22	the	the	DET
cusj-6369	29	23	experimental	experimental	ADJ
cusj-6369	29	24	group	group	NOUN
cusj-6369	29	25	#	#	SYM
cusj-6369	29	26	uorescence	uorescence	NOUN
cusj-6369	29	27	and	and	CCONJ
cusj-6369	29	28	divided	divide	VERB
cusj-6369	29	29	by	by	ADP
cusj-6369	29	30	the	the	DET
cusj-6369	29	31	average	average	ADJ
cusj-6369	29	32	positive	positive	ADJ
cusj-6369	29	33	control	control	NOUN
cusj-6369	29	34	#	#	NOUN
cusj-6369	29	35	uorescence	uorescence	NOUN
cusj-6369	29	36	.	.	PUNCT
cusj-6369	30	1	subtracting	subtract	VERB
cusj-6369	30	2	percent	percent	NOUN
cusj-6369	30	3	activity	activity	NOUN
cusj-6369	30	4	from	from	ADP
cusj-6369	30	5	100	100	NUM
cusj-6369	30	6	%	%	NOUN
cusj-6369	30	7	gave	give	VERB
cusj-6369	30	8	percent	percent	NOUN
cusj-6369	30	9	inhibition	inhibition	NOUN
cusj-6369	30	10	.	.	PUNCT
cusj-6369	31	1	in	in	ADP
cusj-6369	31	2	the	the	DET
cusj-6369	31	3	brain	brain	NOUN
cusj-6369	31	4	,	,	PUNCT
cusj-6369	31	5	phosphate	phosphate	NOUN
cusj-6369	31	6	-	-	PUNCT
cusj-6369	31	7	activated	activate	VERB
cusj-6369	31	8	glutaminase	glutaminase	NOUN
cusj-6369	31	9	catalyzes	catalyze	VERB
cusj-6369	31	10	the	the	DET
cusj-6369	31	11	recycling	recycling	NOUN
cusj-6369	31	12	of	of	ADP
cusj-6369	31	13	glutamine	glutamine	NOUN
cusj-6369	31	14	back	back	ADV
cusj-6369	31	15	to	to	PART
cusj-6369	31	16	glutamate	glutamate	VERB
cusj-6369	31	17	for	for	ADP
cusj-6369	31	18	excitatory	excitatory	ADJ
cusj-6369	31	19	neurotransmission	neurotransmission	NOUN
cusj-6369	31	20	.	.	PUNCT
cusj-6369	32	1	in	in	ADP
cusj-6369	32	2	mice	mouse	NOUN
cusj-6369	32	3	,	,	PUNCT
cusj-6369	32	4	genetic	genetic	ADJ
cusj-6369	32	5	knockdown	knockdown	NOUN
cusj-6369	32	6	of	of	ADP
cusj-6369	32	7	phosphate	phosphate	NOUN
cusj-6369	32	8	-	-	PUNCT
cusj-6369	32	9	activated	activate	VERB
cusj-6369	32	10	glutaminase	glutaminase	NOUN
cusj-6369	32	11	has	have	AUX
cusj-6369	32	12	been	be	AUX
cusj-6369	32	13	shown	show	VERB
cusj-6369	32	14	to	to	PART
cusj-6369	32	15	confer	confer	VERB
cusj-6369	32	16	resilience	resilience	NOUN
cusj-6369	32	17	to	to	ADP
cusj-6369	32	18	schizophrenia	schizophrenia	NOUN
cusj-6369	32	19	-	-	PUNCT
cusj-6369	32	20	like	like	ADJ
cusj-6369	32	21	symptoms	symptom	NOUN
cusj-6369	32	22	,	,	PUNCT
cusj-6369	32	23	suggesting	suggest	VERB
cusj-6369	32	24	that	that	SCONJ
cusj-6369	32	25	inhibition	inhibition	NOUN
cusj-6369	32	26	of	of	ADP
cusj-6369	32	27	glutaminase	glutaminase	NOUN
cusj-6369	32	28	may	may	AUX
cusj-6369	32	29	have	have	VERB
cusj-6369	32	30	therapeutic	therapeutic	ADJ
cusj-6369	32	31	potential	potential	NOUN
cusj-6369	32	32	for	for	ADP
cusj-6369	32	33	the	the	DET
cusj-6369	32	34	pharmacotherapy	pharmacotherapy	NOUN
cusj-6369	32	35	of	of	ADP
cusj-6369	32	36	schizophrenia	schizophrenia	NOUN
cusj-6369	32	37	.	.	PUNCT
cusj-6369	33	1	as	as	SCONJ
cusj-6369	33	2	there	there	PRON
cusj-6369	33	3	are	be	VERB
cusj-6369	33	4	no	no	DET
cusj-6369	33	5	known	known	ADJ
cusj-6369	33	6	neuroactive	neuroactive	ADJ
cusj-6369	33	7	inhibitors	inhibitor	NOUN
cusj-6369	33	8	of	of	ADP
cusj-6369	33	9	glutaminase	glutaminase	NOUN
cusj-6369	33	10	,	,	PUNCT
cusj-6369	33	11	i.e.	i.e.	X
cusj-6369	33	12	inhibitors	inhibitor	NOUN
cusj-6369	33	13	that	that	PRON
cusj-6369	33	14	get	get	VERB
cusj-6369	33	15	into	into	ADP
cusj-6369	33	16	the	the	DET
cusj-6369	33	17	brain	brain	NOUN
cusj-6369	33	18	,	,	PUNCT
cusj-6369	33	19	high	high	ADJ
cusj-6369	33	20	-	-	PUNCT
cusj-6369	33	21	throughput	throughput	NOUN
cusj-6369	33	22	screening	screening	NOUN
cusj-6369	33	23	of	of	ADP
cusj-6369	33	24	a	a	DET
cusj-6369	33	25	library	library	NOUN
cusj-6369	33	26	of	of	ADP
cusj-6369	33	27	58,000	58,000	NUM
cusj-6369	33	28	qhxurdwlyh	qhxurdwlyh	ADJ
cusj-6369	33	29	�	�	PROPN
cusj-6369	33	30	frpsrxqgv	frpsrxqgv	PROPN
cusj-6369	33	31	�	�	PROPN
cusj-6369	33	32	zdv	zdv	PROPN
cusj-6369	33	33	�	�	PROPN
cusj-6369	33	34	frqgxfwhg	frqgxfwhg	PROPN
cusj-6369	33	35	�	�	PROPN
cusj-6369	33	36	xvlqj	xvlqj	PROPN
cusj-6369	33	37	�	�	PROPN
cusj-6369	33	38	d	d	PROPN
cusj-6369	33	39	�	�	PROPN
cusj-6369	33	40	àxruhvfhqfh	àxruhvfhqfh	VERB
cusj-6369	33	41	�	�	NOUN
cusj-6369	33	42	edvhg	edvhg	PROPN
cusj-6369	33	43	�	�	PROPN
cusj-6369	33	44	dvvd\	dvvd\	PROPN
cusj-6369	33	45	�	�	PROPN
cusj-6369	33	46	�	�	PROPN
cusj-6369	33	47	wklv	wklv	PROPN
cusj-6369	33	48	�	�	PROPN
cusj-6369	33	49	vfuhhq	vfuhhq	PROPN
cusj-6369	33	50	�	�	PROPN
cusj-6369	33	51	lghqwl¿hg	lghqwl¿hg	PROPN
cusj-6369	33	52	�	�	PROPN
cusj-6369	33	53	�	�	PROPN
cusj-6369	33	54	�	�	PROPN
cusj-6369	33	55	�	�	PROPN
cusj-6369	33	56	�	�	PROPN
cusj-6369	33	57	srwhqwldo	srwhqwldo	PROPN
cusj-6369	33	58	�	�	PROPN
cusj-6369	33	59	joxwdplqdvh	joxwdplqdvh	PROPN
cusj-6369	33	60	�	�	PROPN
cusj-6369	33	61	lqklelwruv	lqklelwruv	PROPN
cusj-6369	33	62	�	�	PROPN
cusj-6369	33	63	�	�	PROPN
cusj-6369	33	64	$	$	SYM
cusj-6369	33	65	�	�	PROPN
cusj-6369	33	66	vhfrqgdu\	vhfrqgdu\	PROPN
cusj-6369	33	67	�	�	PROPN
cusj-6369	33	68	vfuhhq	vfuhhq	PROPN
cusj-6369	33	69	�	�	PROPN
cusj-6369	33	70	zdv	zdv	PROPN
cusj-6369	33	71	�	�	PROPN
cusj-6369	33	72	fduulhg	fduulhg	PROPN
cusj-6369	33	73	�	�	PROPN
cusj-6369	33	74	rxw	rxw	PROPN
cusj-6369	33	75	�	�	PROPN
cusj-6369	33	76	wr	wr	PROPN
cusj-6369	33	77	�	�	PROPN
cusj-6369	33	78	dvvhvv	dvvhvv	PROPN
cusj-6369	33	79	�	�	PROPN
cusj-6369	33	80	vshfl¿flw\	vshfl¿flw\	NUM
cusj-6369	33	81	�	�	NOUN
cusj-6369	33	82	�	�	PROPN
cusj-6369	33	83	wklv	wklv	PROPN
cusj-6369	33	84	�	�	PROPN
cusj-6369	33	85	\lhoghg	\lhoghg	PROPN
cusj-6369	33	86	�	�	PROPN
cusj-6369	33	87	�	�	PROPN
cusj-6369	33	88	�	�	PROPN
cusj-6369	33	89	�	�	PROPN
cusj-6369	33	90	klwv	klwv	PROPN
cusj-6369	33	91	�	�	PROPN
cusj-6369	33	92	�	�	PROPN
cusj-6369	33	93	�	�	PROPN
cusj-6369	33	94	8vlqj	8vlqj	NUM
cusj-6369	33	95	�	�	PROPN
cusj-6369	33	96	d	d	PROPN
cusj-6369	33	97	�	�	PROPN
cusj-6369	33	98	nlqhwlf	nlqhwlf	PROPN
cusj-6369	33	99	�	�	PROPN
cusj-6369	33	100	dqdo\vlv	dqdo\vlv	PROPN
cusj-6369	33	101	�	�	PROPN
cusj-6369	33	102	�	�	PROPN
cusj-6369	33	103	wzr	wzr	PROPN
cusj-6369	33	104	�	�	PROPN
cusj-6369	33	105	ohdgv	ohdgv	PROPN
cusj-6369	33	106	�	�	PROPN
cusj-6369	33	107	zlwk	zlwk	PROPN
cusj-6369	33	108	�	�	PROPN
cusj-6369	33	109	orz	orz	PROPN
cusj-6369	33	110	�	�	PROPN
cusj-6369	33	111	plfurprodu	plfurprodu	ADJ
cusj-6369	33	112	�	�	PROPN
cusj-6369	33	113	activity	activity	NOUN
cusj-6369	33	114	were	be	AUX
cusj-6369	33	115	found	find	VERB
cusj-6369	33	116	.	.	PUNCT
cusj-6369	34	1	columbia	columbia	PROPN
cusj-6369	34	2	undergraduate	undergraduate	PROPN
cusj-6369	34	3	science	science	PROPN
cusj-6369	34	4	journal	journal	PROPN
cusj-6369	34	5	open	open	ADJ
cusj-6369	34	6	-	-	PUNCT
cusj-6369	34	7	access	access	NOUN
cusj-6369	34	8	publication	publication	NOUN
cusj-6369	34	9	|	|	NOUN
cusj-6369	34	10	http://cusj.columbia.edu	http://cusj.columbia.edu	PROPN
cusj-6369	34	11	3	3	NUM
cusj-6369	34	12	cusjvolume	cusjvolume	VERB
cusj-6369	34	13	6spring	6spring	NUM
cusj-6369	34	14	2012	2012	NUM
cusj-6369	34	15	columbia	columbia	PROPN
cusj-6369	34	16	undergraduate	undergraduate	NOUN
cusj-6369	34	17	sci	sci	PROPN
cusj-6369	34	18	j	j	PROPN
cusj-6369	34	19	http://cusj.columbia.edu	http://cusj.columbia.edu	PROPN
cusj-6369	35	1	p	p	X
cusj-6369	35	2	s	s	X
cusj-6369	35	3	y	y	PROPN
cusj-6369	35	4	c	c	PROPN
cusj-6369	35	5	h	h	PROPN
cusj-6369	35	6	ia	ia	PROPN
cusj-6369	35	7	tr	tr	PROPN
cusj-6369	35	8	y	y	PROPN
cusj-6369	35	9	cusjcolumbia	cusjcolumbia	ADJ
cusj-6369	35	10	undergraduate	undergraduate	NOUN
cusj-6369	35	11	science	science	PROPN
cusj-6369	35	12	journal	journal	PROPN
cusj-6369	35	13	research	research	NOUN
cusj-6369	35	14	articles	article	NOUN
cusj-6369	35	15	4cusj	4cusj	NUM
cusj-6369	36	1	volume	volume	NOUN
cusj-6369	36	2	6spring	6spre	VERB
cusj-6369	36	3	2012	2012	NUM
cusj-6369	36	4	columbia	columbia	PROPN
cusj-6369	36	5	undergraduate	undergraduate	NOUN
cusj-6369	36	6	sci	sci	PROPN
cusj-6369	36	7	j	j	PROPN
cusj-6369	36	8	http://cusj.columbia.edu	http://cusj.columbia.edu	PROPN
cusj-6369	37	1	p	p	X
cusj-6369	37	2	s	s	X
cusj-6369	37	3	y	y	PROPN
cusj-6369	37	4	c	c	NOUN
cusj-6369	37	5	h	h	NOUN
cusj-6369	38	1	iatr	iatr	ADV
cusj-6369	38	2	y	y	PROPN
cusj-6369	38	3	schizophrenia	schizophrenia	NOUN
cusj-6369	38	4	is	be	AUX
cusj-6369	38	5	a	a	DET
cusj-6369	38	6	complex	complex	ADJ
cusj-6369	38	7	and	and	CCONJ
cusj-6369	38	8	diverse	diverse	ADJ
cusj-6369	38	9	neuropsychiatric	neuropsychiatric	ADJ
cusj-6369	38	10	disorder	disorder	NOUN
cusj-6369	38	11	that	that	PRON
cusj-6369	38	12	a$ects	a$ect	VERB
cusj-6369	38	13	approximately	approximately	ADV
cusj-6369	38	14	one	one	NUM
cusj-6369	38	15	percent	percent	NOUN
cusj-6369	38	16	of	of	ADP
cusj-6369	38	17	the	the	DET
cusj-6369	38	18	world	world	NOUN
cusj-6369	38	19	population	population	NOUN
cusj-6369	38	20	.	.	PUNCT
cusj-6369	39	1	symptoms	symptom	NOUN
cusj-6369	39	2	typically	typically	ADV
cusj-6369	39	3	present	present	ADJ
cusj-6369	39	4	in	in	ADP
cusj-6369	39	5	schizophrenia	schizophrenia	NOUN
cusj-6369	39	6	are	be	AUX
cusj-6369	39	7	placed	place	VERB
cusj-6369	39	8	into	into	ADP
cusj-6369	39	9	three	three	NUM
cusj-6369	39	10	categories	category	NOUN
cusj-6369	39	11	:	:	PUNCT
cusj-6369	39	12	positive	positive	ADJ
cusj-6369	39	13	,	,	PUNCT
cusj-6369	39	14	such	such	ADJ
cusj-6369	39	15	as	as	ADP
cusj-6369	39	16	hallucinations	hallucination	NOUN
cusj-6369	39	17	,	,	PUNCT
cusj-6369	39	18	negative	negative	ADJ
cusj-6369	39	19	,	,	PUNCT
cusj-6369	39	20	such	such	ADJ
cusj-6369	39	21	as	as	ADP
cusj-6369	39	22	paucity	paucity	NOUN
cusj-6369	39	23	of	of	ADP
cusj-6369	39	24	speech	speech	NOUN
cusj-6369	39	25	and	and	CCONJ
cusj-6369	39	26	social	social	ADJ
cusj-6369	39	27	withdrawal	withdrawal	NOUN
cusj-6369	39	28	,	,	PUNCT
cusj-6369	39	29	and	and	CCONJ
cusj-6369	39	30	cognitive	cognitive	ADJ
cusj-6369	39	31	,	,	PUNCT
cusj-6369	39	32	such	such	ADJ
cusj-6369	39	33	as	as	ADP
cusj-6369	39	34	conceptual	conceptual	ADJ
cusj-6369	39	35	disorganization	disorganization	NOUN
cusj-6369	39	36	and	and	CCONJ
cusj-6369	39	37	de!cits	de!cit	NOUN
cusj-6369	39	38	in	in	ADP
cusj-6369	39	39	working	working	NOUN
cusj-6369	39	40	memory	memory	NOUN
cusj-6369	39	41	.	.	PUNCT
cusj-6369	40	1	"	"	PUNCT
cusj-6369	40	2	e	e	X
cusj-6369	40	3	treatment	treatment	NOUN
cusj-6369	40	4	of	of	ADP
cusj-6369	40	5	schizophrenia	schizophrenia	NOUN
cusj-6369	40	6	has	have	AUX
cusj-6369	40	7	focused	focus	VERB
cusj-6369	40	8	on	on	ADP
cusj-6369	40	9	targeting	target	VERB
cusj-6369	40	10	dopamine	dopamine	NOUN
cusj-6369	40	11	hyperactivity	hyperactivity	NOUN
cusj-6369	40	12	with	with	ADP
cusj-6369	40	13	anti	anti	ADJ
cusj-6369	40	14	-	-	ADJ
cusj-6369	40	15	psychotic	psychotic	ADJ
cusj-6369	40	16	drugs	drug	NOUN
cusj-6369	40	17	.	.	PUNCT
cusj-6369	41	1	"	"	PUNCT
cusj-6369	41	2	e	e	X
cusj-6369	41	3	dopamine	dopamine	NOUN
cusj-6369	41	4	hypothesis	hypothesis	NOUN
cusj-6369	41	5	,	,	PUNCT
cusj-6369	41	6	which	which	PRON
cusj-6369	41	7	attributes	attribute	VERB
cusj-6369	41	8	the	the	DET
cusj-6369	41	9	symptoms	symptom	NOUN
cusj-6369	41	10	of	of	ADP
cusj-6369	41	11	schizophrenia	schizophrenia	NOUN
cusj-6369	41	12	to	to	PART
cusj-6369	41	13	hyperactive	hyperactive	VERB
cusj-6369	41	14	dopaminergic	dopaminergic	ADJ
cusj-6369	41	15	signal	signal	NOUN
cusj-6369	41	16	transduction	transduction	NOUN
cusj-6369	41	17	in	in	ADP
cusj-6369	41	18	the	the	DET
cusj-6369	41	19	striatum	striatum	NOUN
cusj-6369	41	20	and	and	CCONJ
cusj-6369	41	21	,	,	PUNCT
cusj-6369	41	22	more	more	ADV
cusj-6369	41	23	broadly	broadly	ADV
cusj-6369	41	24	,	,	PUNCT
cusj-6369	41	25	the	the	DET
cusj-6369	41	26	mesolimbic	mesolimbic	ADJ
cusj-6369	41	27	pathway	pathway	NOUN
cusj-6369	41	28	,	,	PUNCT
cusj-6369	41	29	rose	rise	VERB
cusj-6369	41	30	to	to	ADP
cusj-6369	41	31	prominence	prominence	NOUN
cusj-6369	41	32	with	with	ADP
cusj-6369	41	33	the	the	DET
cusj-6369	41	34	discovery	discovery	NOUN
cusj-6369	41	35	that	that	PRON
cusj-6369	41	36	many	many	ADJ
cusj-6369	41	37	common	common	ADJ
cusj-6369	41	38	antipsychotic	antipsychotic	ADJ
cusj-6369	41	39	drugs	drug	NOUN
cusj-6369	41	40	,	,	PUNCT
cusj-6369	41	41	such	such	ADJ
cusj-6369	41	42	as	as	ADP
cusj-6369	41	43	chlorpromazine	chlorpromazine	NOUN
cusj-6369	41	44	and	and	CCONJ
cusj-6369	41	45	clozapine	clozapine	NOUN
cusj-6369	41	46	,	,	PUNCT
cusj-6369	41	47	work	work	NOUN
cusj-6369	41	48	by	by	ADP
cusj-6369	41	49	binding	bind	VERB
cusj-6369	41	50	to	to	ADP
cusj-6369	41	51	postsynaptic	postsynaptic	ADJ
cusj-6369	41	52	dopamine	dopamine	NOUN
cusj-6369	41	53	receptors	receptor	NOUN
cusj-6369	41	54	,	,	PUNCT
cusj-6369	41	55	notably	notably	ADV
cusj-6369	41	56	d2	d2	NOUN
cusj-6369	41	57	receptors	receptor	NOUN
cusj-6369	41	58	,	,	PUNCT
cusj-6369	41	59	and	and	CCONJ
cusj-6369	41	60	interfering	interfere	VERB
cusj-6369	41	61	with	with	ADP
cusj-6369	41	62	dopamine	dopamine	NOUN
cusj-6369	41	63	signal	signal	NOUN
cusj-6369	41	64	transduction	transduction	NOUN
cusj-6369	41	65	(	(	PUNCT
cusj-6369	41	66	creese	creese	NOUN
cusj-6369	41	67	,	,	PUNCT
cusj-6369	41	68	1976	1976	NUM
cusj-6369	41	69	;	;	PUNCT
cusj-6369	41	70	seeman	seeman	PROPN
cusj-6369	41	71	,	,	PUNCT
cusj-6369	41	72	1975	1975	NUM
cusj-6369	41	73	;	;	PUNCT
cusj-6369	41	74	van	van	PROPN
cusj-6369	41	75	rossum	rossum	PROPN
cusj-6369	41	76	,	,	PUNCT
cusj-6369	41	77	1966	1966	NUM
cusj-6369	41	78	;	;	PUNCT
cusj-6369	41	79	matthyse	matthyse	NOUN
cusj-6369	41	80	,	,	PUNCT
cusj-6369	41	81	1973	1973	NUM
cusj-6369	41	82	)	)	PUNCT
cusj-6369	41	83	.	.	PUNCT
cusj-6369	42	1	however	however	ADV
cusj-6369	42	2	,	,	PUNCT
cusj-6369	42	3	the	the	DET
cusj-6369	42	4	dopamine	dopamine	NOUN
cusj-6369	42	5	hypothesis	hypothesis	NOUN
cusj-6369	42	6	does	do	AUX
cusj-6369	42	7	not	not	PART
cusj-6369	42	8	fully	fully	ADV
cusj-6369	42	9	explain	explain	VERB
cusj-6369	42	10	schizophrenia	schizophrenia	NOUN
cusj-6369	42	11	.	.	PUNCT
cusj-6369	43	1	one	one	NUM
cusj-6369	43	2	problem	problem	NOUN
cusj-6369	43	3	is	be	AUX
cusj-6369	43	4	that	that	SCONJ
cusj-6369	43	5	these	these	DET
cusj-6369	43	6	dopamine	dopamine	NOUN
cusj-6369	43	7	receptor	receptor	NOUN
cusj-6369	43	8	antagonists	antagonist	NOUN
cusj-6369	43	9	are	be	AUX
cusj-6369	43	10	largely	largely	ADV
cusj-6369	43	11	ine$ective	ine$ective	ADJ
cusj-6369	43	12	in	in	ADP
cusj-6369	43	13	treating	treat	VERB
cusj-6369	43	14	the	the	DET
cusj-6369	43	15	negative	negative	ADJ
cusj-6369	43	16	and	and	CCONJ
cusj-6369	43	17	cognitive	cognitive	ADJ
cusj-6369	43	18	symptoms	symptom	NOUN
cusj-6369	43	19	of	of	ADP
cusj-6369	43	20	schizophrenia	schizophrenia	NOUN
cusj-6369	43	21	,	,	PUNCT
cusj-6369	43	22	which	which	PRON
cusj-6369	43	23	suggests	suggest	VERB
cusj-6369	43	24	that	that	SCONJ
cusj-6369	43	25	dopaminergic	dopaminergic	ADJ
cusj-6369	43	26	hyperactivity	hyperactivity	NOUN
cusj-6369	43	27	may	may	AUX
cusj-6369	43	28	be	be	AUX
cusj-6369	43	29	unrelated	unrelated	ADJ
cusj-6369	43	30	to	to	ADP
cusj-6369	43	31	this	this	DET
cusj-6369	43	32	class	class	NOUN
cusj-6369	43	33	of	of	ADP
cusj-6369	43	34	symptoms	symptom	NOUN
cusj-6369	43	35	(	(	PUNCT
cusj-6369	43	36	davis	davis	PROPN
cusj-6369	43	37	,	,	PUNCT
cusj-6369	43	38	1991	1991	NUM
cusj-6369	43	39	;	;	PUNCT
cusj-6369	43	40	javitt	javitt	NOUN
cusj-6369	43	41	,	,	PUNCT
cusj-6369	43	42	2010	2010	NUM
cusj-6369	43	43	;	;	PUNCT
cusj-6369	43	44	kellendonk	kellendonk	PROPN
cusj-6369	43	45	,	,	PUNCT
cusj-6369	43	46	2006	2006	NUM
cusj-6369	43	47	)	)	PUNCT
cusj-6369	43	48	.	.	PUNCT
cusj-6369	44	1	moreover	moreover	ADV
cusj-6369	44	2	,	,	PUNCT
cusj-6369	44	3	a	a	DET
cusj-6369	44	4	signi!cant	signi!cant	ADJ
cusj-6369	44	5	number	number	NOUN
cusj-6369	44	6	of	of	ADP
cusj-6369	44	7	patients	patient	NOUN
cusj-6369	44	8	with	with	ADP
cusj-6369	44	9	schizophrenia	schizophrenia	NOUN
cusj-6369	44	10	do	do	AUX
cusj-6369	44	11	not	not	PART
cusj-6369	44	12	respond	respond	VERB
cusj-6369	44	13	to	to	ADP
cusj-6369	44	14	these	these	DET
cusj-6369	44	15	drugs	drug	NOUN
cusj-6369	44	16	,	,	PUNCT
cusj-6369	44	17	which	which	PRON
cusj-6369	44	18	also	also	ADV
cusj-6369	44	19	may	may	AUX
cusj-6369	44	20	be	be	AUX
cusj-6369	44	21	due	due	ADJ
cusj-6369	44	22	to	to	ADP
cusj-6369	44	23	the	the	DET
cusj-6369	44	24	involvement	involvement	NOUN
cusj-6369	44	25	of	of	ADP
cusj-6369	44	26	other	other	ADJ
cusj-6369	44	27	neurochemical	neurochemical	ADJ
cusj-6369	44	28	pathways	pathway	NOUN
cusj-6369	44	29	(	(	PUNCT
cusj-6369	44	30	davis	davis	PROPN
cusj-6369	44	31	1991	1991	NUM
cusj-6369	44	32	)	)	PUNCT
cusj-6369	44	33	.	.	PUNCT
cusj-6369	45	1	more	more	ADV
cusj-6369	45	2	recently	recently	ADV
cusj-6369	45	3	,	,	PUNCT
cusj-6369	45	4	abnormal	abnormal	ADJ
cusj-6369	45	5	glutamate	glutamate	NOUN
cusj-6369	45	6	transmission	transmission	NOUN
cusj-6369	45	7	has	have	AUX
cusj-6369	45	8	been	be	AUX
cusj-6369	45	9	implicated	implicate	VERB
cusj-6369	45	10	in	in	ADP
cusj-6369	45	11	the	the	DET
cusj-6369	45	12	pathophysiology	pathophysiology	NOUN
cusj-6369	45	13	of	of	ADP
cusj-6369	45	14	schizophrenia	schizophrenia	NOUN
cusj-6369	45	15	.	.	PUNCT
cusj-6369	46	1	glutamate	glutamate	NOUN
cusj-6369	46	2	is	be	AUX
cusj-6369	46	3	the	the	DET
cusj-6369	46	4	major	major	ADJ
cusj-6369	46	5	excitatory	excitatory	NOUN
cusj-6369	46	6	neurotransmitter	neurotransmitter	NOUN
cusj-6369	46	7	in	in	ADP
cusj-6369	46	8	the	the	DET
cusj-6369	46	9	central	central	ADJ
cusj-6369	46	10	nervous	nervous	ADJ
cusj-6369	46	11	system	system	NOUN
cusj-6369	46	12	.	.	PUNCT
cusj-6369	47	1	under	under	ADP
cusj-6369	47	2	normal	normal	ADJ
cusj-6369	47	3	conditions	condition	NOUN
cusj-6369	47	4	it	it	PRON
cusj-6369	47	5	is	be	AUX
cusj-6369	47	6	produced	produce	VERB
cusj-6369	47	7	and	and	CCONJ
cusj-6369	47	8	maintained	maintain	VERB
cusj-6369	47	9	at	at	ADP
cusj-6369	47	10	a	a	DET
cusj-6369	47	11	low	low	ADJ
cusj-6369	47	12	extracellular	extracellular	ADJ
cusj-6369	47	13	concentration	concentration	NOUN
cusj-6369	47	14	through	through	ADP
cusj-6369	47	15	the	the	DET
cusj-6369	47	16	glutamate	glutamate	NOUN
cusj-6369	47	17	-	-	PUNCT
cusj-6369	47	18	glutamine	glutamine	NOUN
cusj-6369	47	19	cycle	cycle	NOUN
cusj-6369	47	20	(	(	PUNCT
cusj-6369	47	21	sanacora	sanacora	NOUN
cusj-6369	47	22	,	,	PUNCT
cusj-6369	47	23	2008	2008	NUM
cusj-6369	47	24	)	)	PUNCT
cusj-6369	47	25	.	.	PUNCT
cusj-6369	48	1	"	"	PUNCT
cusj-6369	48	2	e	e	X
cusj-6369	48	3	importance	importance	NOUN
cusj-6369	48	4	of	of	ADP
cusj-6369	48	5	glutamate	glutamate	ADJ
cusj-6369	48	6	transmission	transmission	NOUN
cusj-6369	48	7	in	in	ADP
cusj-6369	48	8	schizophrenia	schizophrenia	NOUN
cusj-6369	48	9	and	and	CCONJ
cusj-6369	48	10	psychosis	psychosis	NOUN
cusj-6369	48	11	was	be	AUX
cusj-6369	48	12	realized	realize	VERB
cusj-6369	48	13	with	with	ADP
cusj-6369	48	14	the	the	DET
cusj-6369	48	15	discovery	discovery	NOUN
cusj-6369	48	16	that	that	PRON
cusj-6369	48	17	drugs	drug	NOUN
cusj-6369	48	18	like	like	ADP
cusj-6369	48	19	phencyclidine	phencyclidine	NOUN
cusj-6369	48	20	(	(	PUNCT
cusj-6369	48	21	pcp	pcp	NOUN
cusj-6369	48	22	)	)	PUNCT
cusj-6369	48	23	cause	cause	VERB
cusj-6369	48	24	symptoms	symptom	NOUN
cusj-6369	48	25	that	that	PRON
cusj-6369	48	26	are	be	AUX
cusj-6369	48	27	nearly	nearly	ADV
cusj-6369	48	28	indistinguishable	indistinguishable	ADJ
cusj-6369	48	29	from	from	ADP
cusj-6369	48	30	those	those	PRON
cusj-6369	48	31	of	of	ADP
cusj-6369	48	32	schizophrenia	schizophrenia	NOUN
cusj-6369	48	33	by	by	ADP
cusj-6369	48	34	acting	act	VERB
cusj-6369	48	35	as	as	ADP
cusj-6369	48	36	an	an	DET
cusj-6369	48	37	antagonist	antagonist	NOUN
cusj-6369	48	38	to	to	ADP
cusj-6369	48	39	n	n	CCONJ
cusj-6369	48	40	-	-	PUNCT
cusj-6369	48	41	methyl	methyl	NOUN
cusj-6369	48	42	d	d	NOUN
cusj-6369	48	43	-	-	PUNCT
cusj-6369	48	44	aspartate	aspartate	ADJ
cusj-6369	48	45	(	(	PUNCT
cusj-6369	48	46	nmda	nmda	ADJ
cusj-6369	48	47	)	)	PUNCT
cusj-6369	48	48	receptors	receptor	NOUN
cusj-6369	48	49	to	to	PART
cusj-6369	48	50	which	which	PRON
cusj-6369	48	51	glutamate	glutamate	NOUN
cusj-6369	48	52	is	be	AUX
cusj-6369	48	53	an	an	DET
cusj-6369	48	54	agonist	agonist	NOUN
cusj-6369	48	55	.	.	PUNCT
cusj-6369	49	1	since	since	SCONJ
cusj-6369	49	2	then	then	ADV
cusj-6369	49	3	,	,	PUNCT
cusj-6369	49	4	many	many	ADJ
cusj-6369	49	5	studies	study	NOUN
cusj-6369	49	6	have	have	AUX
cusj-6369	49	7	shown	show	VERB
cusj-6369	49	8	that	that	SCONJ
cusj-6369	49	9	processes	process	NOUN
cusj-6369	49	10	that	that	PRON
cusj-6369	49	11	modulate	modulate	VERB
cusj-6369	49	12	normal	normal	ADJ
cusj-6369	49	13	glutamatergic	glutamatergic	ADJ
cusj-6369	49	14	signaling	signaling	NOUN
cusj-6369	49	15	may	may	AUX
cusj-6369	49	16	have	have	VERB
cusj-6369	49	17	bene!cial	bene!cial	ADJ
cusj-6369	49	18	e$ects	e$ects	PROPN
cusj-6369	49	19	on	on	ADP
cusj-6369	49	20	positive	positive	ADJ
cusj-6369	49	21	,	,	PUNCT
cusj-6369	49	22	negative	negative	ADJ
cusj-6369	49	23	,	,	PUNCT
cusj-6369	49	24	and	and	CCONJ
cusj-6369	49	25	cognitive	cognitive	ADJ
cusj-6369	49	26	symptoms	symptom	NOUN
cusj-6369	49	27	of	of	ADP
cusj-6369	49	28	schizophrenia	schizophrenia	NOUN
cusj-6369	49	29	(	(	PUNCT
cusj-6369	49	30	javitt	javitt	PROPN
cusj-6369	49	31	2010	2010	NUM
cusj-6369	49	32	;	;	PUNCT
cusj-6369	49	33	vinson	vinson	PROPN
cusj-6369	49	34	and	and	CCONJ
cusj-6369	49	35	conn	conn	PROPN
cusj-6369	49	36	2011	2011	NUM
cusj-6369	49	37	;	;	PUNCT
cusj-6369	49	38	gaisler	gaisler	NOUN
cusj-6369	49	39	-	-	PUNCT
cusj-6369	49	40	solomon	solomon	PROPN
cusj-6369	49	41	et	et	PROPN
cusj-6369	49	42	al	al	PROPN
cusj-6369	49	43	.	.	PROPN
cusj-6369	49	44	,	,	PUNCT
cusj-6369	49	45	2009	2009	NUM
cusj-6369	49	46	)	)	PUNCT
cusj-6369	49	47	.	.	PUNCT
cusj-6369	50	1	in	in	ADP
cusj-6369	50	2	particular	particular	ADJ
cusj-6369	50	3	,	,	PUNCT
cusj-6369	50	4	mice	mouse	NOUN
cusj-6369	50	5	haploinsu%cient	haploinsu%cient	NOUN
cusj-6369	50	6	for	for	ADP
cusj-6369	50	7	phosphate	phosphate	NOUN
cusj-6369	50	8	-	-	PUNCT
cusj-6369	50	9	activated	activate	VERB
cusj-6369	50	10	glutaminase	glutaminase	NOUN
cusj-6369	50	11	(	(	PUNCT
cusj-6369	50	12	pag	pag	PROPN
cusj-6369	50	13	)	)	PUNCT
cusj-6369	50	14	show	show	VERB
cusj-6369	50	15	a	a	DET
cusj-6369	50	16	reduction	reduction	NOUN
cusj-6369	50	17	in	in	ADP
cusj-6369	50	18	glutamatergic	glutamatergic	ADJ
cusj-6369	50	19	synaptic	synaptic	ADJ
cusj-6369	50	20	transmission	transmission	NOUN
cusj-6369	50	21	,	,	PUNCT
cusj-6369	50	22	are	be	AUX
cusj-6369	50	23	behaviorally	behaviorally	ADV
cusj-6369	50	24	quite	quite	ADV
cusj-6369	50	25	normal	normal	ADJ
cusj-6369	50	26	,	,	PUNCT
cusj-6369	50	27	and	and	CCONJ
cusj-6369	50	28	are	be	AUX
cusj-6369	50	29	resilient	resilient	ADJ
cusj-6369	50	30	to	to	ADP
cusj-6369	50	31	the	the	DET
cusj-6369	50	32	e$ects	e$ects	PROPN
cusj-6369	50	33	of	of	ADP
cusj-6369	50	34	pro	pro	ADJ
cusj-6369	50	35	-	-	ADJ
cusj-6369	50	36	psychotic	psychotic	ADJ
cusj-6369	50	37	drugs	drug	NOUN
cusj-6369	50	38	.	.	PUNCT
cusj-6369	51	1	pag	pag	PROPN
cusj-6369	51	2	is	be	AUX
cusj-6369	51	3	an	an	DET
cusj-6369	51	4	enzyme	enzyme	NOUN
cusj-6369	51	5	that	that	PRON
cusj-6369	51	6	catalyzes	catalyze	VERB
cusj-6369	51	7	the	the	DET
cusj-6369	51	8	presynaptic	presynaptic	ADJ
cusj-6369	51	9	conversion	conversion	NOUN
cusj-6369	51	10	of	of	ADP
cusj-6369	51	11	glutamine	glutamine	NOUN
cusj-6369	51	12	to	to	PART
cusj-6369	51	13	glutamate	glutamate	VERB
cusj-6369	51	14	in	in	ADP
cusj-6369	51	15	neuronal	neuronal	ADJ
cusj-6369	51	16	mitochondria	mitochondria	NOUN
cusj-6369	51	17	,	,	PUNCT
cusj-6369	51	18	"	"	PUNCT
cusj-6369	51	19	ese	ese	NOUN
cusj-6369	51	20	!	!	PUNCT
cusj-6369	52	1	ndings	nding	NOUN
cusj-6369	52	2	suggest	suggest	VERB
cusj-6369	52	3	that	that	SCONJ
cusj-6369	52	4	the	the	DET
cusj-6369	52	5	reduction	reduction	NOUN
cusj-6369	52	6	of	of	ADP
cusj-6369	52	7	glutamate	glutamate	ADJ
cusj-6369	52	8	release	release	NOUN
cusj-6369	52	9	through	through	ADP
cusj-6369	52	10	the	the	DET
cusj-6369	52	11	genetic	genetic	ADJ
cusj-6369	52	12	reduction	reduction	NOUN
cusj-6369	52	13	of	of	ADP
cusj-6369	52	14	pag	pag	PROPN
cusj-6369	52	15	confers	confer	NOUN
cusj-6369	52	16	resilience	resilience	NOUN
cusj-6369	52	17	to	to	ADP
cusj-6369	52	18	a	a	DET
cusj-6369	52	19	schizophrenia	schizophrenia	NOUN
cusj-6369	52	20	-	-	PUNCT
cusj-6369	52	21	like	like	ADJ
cusj-6369	52	22	phenotype	phenotype	NOUN
cusj-6369	52	23	in	in	ADP
cusj-6369	52	24	mice	mouse	NOUN
cusj-6369	52	25	,	,	PUNCT
cusj-6369	52	26	and	and	CCONJ
cusj-6369	52	27	that	that	SCONJ
cusj-6369	52	28	the	the	DET
cusj-6369	52	29	inhibition	inhibition	NOUN
cusj-6369	52	30	of	of	ADP
cusj-6369	52	31	pag	pag	PROPN
cusj-6369	52	32	may	may	AUX
cusj-6369	52	33	have	have	VERB
cusj-6369	52	34	therapeutic	therapeutic	ADJ
cusj-6369	52	35	potential	potential	NOUN
cusj-6369	52	36	in	in	ADP
cusj-6369	52	37	the	the	DET
cusj-6369	52	38	pharmacotherapy	pharmacotherapy	NOUN
cusj-6369	52	39	of	of	ADP
cusj-6369	52	40	schizophrenia	schizophrenia	NOUN
cusj-6369	52	41	(	(	PUNCT
cusj-6369	52	42	gaisler	gaisler	NOUN
cusj-6369	52	43	-	-	PUNCT
cusj-6369	52	44	solomon	solomon	PROPN
cusj-6369	52	45	et	et	PROPN
cusj-6369	52	46	al	al	PROPN
cusj-6369	52	47	.	.	PROPN
cusj-6369	52	48	,	,	PUNCT
cusj-6369	52	49	2009	2009	NUM
cusj-6369	52	50	)	)	PUNCT
cusj-6369	52	51	.	.	PUNCT
cusj-6369	53	1	pag	pag	PROPN
cusj-6369	53	2	inhibition	inhibition	NOUN
cusj-6369	53	3	also	also	ADV
cusj-6369	53	4	appears	appear	VERB
cusj-6369	53	5	to	to	PART
cusj-6369	53	6	have	have	VERB
cusj-6369	53	7	therapeutic	therapeutic	ADJ
cusj-6369	53	8	potential	potential	NOUN
cusj-6369	53	9	in	in	ADP
cusj-6369	53	10	several	several	ADJ
cusj-6369	53	11	diseases	disease	NOUN
cusj-6369	53	12	beyond	beyond	ADP
cusj-6369	53	13	schizophrenia	schizophrenia	NOUN
cusj-6369	53	14	,	,	PUNCT
cusj-6369	53	15	such	such	ADJ
cusj-6369	53	16	as	as	ADP
cusj-6369	53	17	in	in	ADP
cusj-6369	53	18	the	the	DET
cusj-6369	53	19	treatment	treatment	NOUN
cusj-6369	53	20	of	of	ADP
cusj-6369	53	21	cancer	cancer	NOUN
cusj-6369	53	22	,	,	PUNCT
cusj-6369	53	23	and	and	CCONJ
cusj-6369	53	24	hiv	hiv	PROPN
cusj-6369	53	25	-	-	PUNCT
cusj-6369	53	26	associated	associate	VERB
cusj-6369	53	27	neurocogniidenti!cation	neurocogniidenti!cation	NOUN
cusj-6369	53	28	of	of	ADP
cusj-6369	53	29	inhibitors	inhibitor	NOUN
cusj-6369	53	30	of	of	ADP
cusj-6369	53	31	phosphate	phosphate	NOUN
cusj-6369	53	32	-	-	PUNCT
cusj-6369	53	33	activated	activate	VERB
cusj-6369	53	34	glutaminase	glutaminase	NOUN
cusj-6369	53	35	for	for	ADP
cusj-6369	53	36	the	the	DET
cusj-6369	53	37	pharmacotherapy	pharmacotherapy	NOUN
cusj-6369	53	38	of	of	ADP
cusj-6369	53	39	schizophrenia	schizophrenia	PROPN
cusj-6369	53	40	cristina	cristina	PROPN
cusj-6369	53	41	sorrento	sorrento	PROPN
cusj-6369	53	42	1,3	1,3	PROPN
cusj-6369	53	43	,	,	PUNCT
cusj-6369	53	44	*	*	PUNCT
cusj-6369	53	45	,	,	PUNCT
cusj-6369	53	46	stephen	stephen	PROPN
cusj-6369	53	47	rayport	rayport	PROPN
cusj-6369	53	48	1,3	1,3	NUM
cusj-6369	53	49	,	,	PUNCT
cusj-6369	53	50	andra	andra	PROPN
cusj-6369	53	51	mihali	mihali	PROPN
cusj-6369	53	52	1,3	1,3	NUM
cusj-6369	53	53	,	,	PUNCT
cusj-6369	53	54	genevieve	genevieve	PROPN
cusj-6369	53	55	kaunitz	kaunitz	PROPN
cusj-6369	53	56	1,3	1,3	NUM
cusj-6369	53	57	,	,	PUNCT
cusj-6369	53	58	shreya	shreya	PROPN
cusj-6369	53	59	subramani	subramani	VERB
cusj-6369	53	60	1,3	1,3	NUM
cusj-6369	53	61	,	,	PUNCT
cusj-6369	53	62	joanne	joanne	PROPN
cusj-6369	53	63	macdonald	macdonald	PROPN
cusj-6369	53	64	2	2	NUM
cusj-6369	53	65	,	,	PUNCT
cusj-6369	53	66	francine	francine	PROPN
cusj-6369	53	67	katz	katz	PROPN
cusj-6369	53	68	2	2	NUM
cusj-6369	53	69	departments	department	NOUN
cusj-6369	53	70	of	of	ADP
cusj-6369	53	71	psychiatry1	psychiatry1	PROPN
cusj-6369	53	72	and	and	CCONJ
cusj-6369	53	73	medicine2	medicine2	PROPN
cusj-6369	53	74	,	,	PUNCT
cusj-6369	53	75	columbia	columbia	PROPN
cusj-6369	53	76	university	university	PROPN
cusj-6369	53	77	,	,	PUNCT
cusj-6369	53	78	new	new	PROPN
cusj-6369	53	79	york	york	PROPN
cusj-6369	53	80	,	,	PUNCT
cusj-6369	53	81	ny	ny	PROPN
cusj-6369	53	82	10032	10032	NUM
cusj-6369	53	83	departments	department	NOUN
cusj-6369	53	84	of	of	ADP
cusj-6369	53	85	molecular	molecular	ADJ
cusj-6369	53	86	therapeutics3	therapeutics3	PROPN
cusj-6369	53	87	,	,	PUNCT
cusj-6369	53	88	new	new	PROPN
cusj-6369	53	89	york	york	PROPN
cusj-6369	53	90	state	state	PROPN
cusj-6369	53	91	psychiatric	psychiatric	PROPN
cusj-6369	53	92	insitute	insitute	PROPN
cusj-6369	53	93	,	,	PUNCT
cusj-6369	53	94	new	new	PROPN
cusj-6369	53	95	york	york	PROPN
cusj-6369	53	96	,	,	PUNCT
cusj-6369	53	97	ny	ny	PROPN
cusj-6369	53	98	10032	10032	NUM
cusj-6369	53	99	copyright	copyright	NOUN
cusj-6369	53	100	:	:	PUNCT
cusj-6369	54	1	©	©	PROPN
cusj-6369	54	2	2012	2012	NUM
cusj-6369	54	3	the	the	DET
cusj-6369	54	4	trustees	trustee	NOUN
cusj-6369	54	5	of	of	ADP
cusj-6369	54	6	columbia	columbia	PROPN
cusj-6369	54	7	university	university	PROPN
cusj-6369	54	8	,	,	PUNCT
cusj-6369	54	9	columbia	columbia	PROPN
cusj-6369	54	10	university	university	PROPN
cusj-6369	54	11	libraries	library	NOUN
cusj-6369	54	12	,	,	PUNCT
cusj-6369	54	13	some	some	DET
cusj-6369	54	14	rights	right	NOUN
cusj-6369	54	15	reserved	reserve	VERB
cusj-6369	54	16	,	,	PUNCT
cusj-6369	54	17	sorrento	sorrento	PROPN
cusj-6369	54	18	,	,	PUNCT
cusj-6369	54	19	et	et	PROPN
cusj-6369	54	20	al	al	PROPN
cusj-6369	54	21	.	.	PROPN
cusj-6369	54	22	received	receive	VERB
cusj-6369	54	23	1/1/2012	1/1/2012	NUM
cusj-6369	54	24	.	.	PUNCT
cusj-6369	55	1	accepted	accept	VERB
cusj-6369	55	2	2/1/2012	2/1/2012	NOUN
cusj-6369	55	3	.	.	PUNCT
cusj-6369	56	1	published	publish	VERB
cusj-6369	56	2	1/1/12	1/1/12	NUM
cusj-6369	56	3	*	*	SYM
cusj-6369	56	4	to	to	PART
cusj-6369	56	5	whom	whom	PRON
cusj-6369	56	6	correspondence	correspondence	NOUN
cusj-6369	56	7	should	should	AUX
cusj-6369	56	8	be	be	AUX
cusj-6369	56	9	addressed	address	VERB
cusj-6369	56	10	:	:	PUNCT
cusj-6369	56	11	departments	department	NOUN
cusj-6369	56	12	of	of	ADP
cusj-6369	56	13	psychiatry	psychiatry	NOUN
cusj-6369	56	14	and	and	CCONJ
cusj-6369	56	15	medicine	medicine	NOUN
cusj-6369	56	16	,	,	PUNCT
cusj-6369	56	17	columbia	columbia	PROPN
cusj-6369	56	18	university	university	PROPN
cusj-6369	56	19	,	,	PUNCT
cusj-6369	56	20	new	new	PROPN
cusj-6369	56	21	york	york	PROPN
cusj-6369	56	22	,	,	PUNCT
cusj-6369	56	23	ny	ny	PROPN
cusj-6369	56	24	10032	10032	NUM
cusj-6369	56	25	cristinasorrento75@gmail.com	cristinasorrento75@gmail.com	PROPN
cusj-6369	56	26	abstract	abstract	ADJ
cusj-6369	56	27	introduction	introduction	NOUN
cusj-6369	56	28	figure	figure	NOUN
cusj-6369	56	29	1	1	NUM
cusj-6369	56	30	7kh	7kh	PROPN
cusj-6369	56	31	�	�	PROPN
cusj-6369	56	32	vwhsv	vwhsv	PROPN
cusj-6369	56	33	�	�	PROPN
cusj-6369	56	34	ri	ri	PROPN
cusj-6369	56	35	�	�	PROPN
cusj-6369	56	36	wkh	wkh	PROPN
cusj-6369	56	37	�	�	PROPN
cusj-6369	56	38	àxruhvfhqfh	àxruhvfhqfh	VERB
cusj-6369	56	39	�	�	NOUN
cusj-6369	56	40	edvhg	edvhg	PROPN
cusj-6369	56	41	�	�	PROPN
cusj-6369	56	42	dvvd\	dvvd\	PROPN
cusj-6369	56	43	�	�	PROPN
cusj-6369	56	44	iru	iru	PROPN
cusj-6369	56	45	�	�	PROPN
cusj-6369	56	46	vwxg\lqj	vwxg\lqj	PROPN
cusj-6369	56	47	�	�	PROPN
cusj-6369	56	48	wkh	wkh	PROPN
cusj-6369	56	49	�	�	PROPN
cusj-6369	56	50	dfwlylw\	dfwlylw\	PROPN
cusj-6369	56	51	�	�	PROPN
cusj-6369	56	52	ri	ri	PROPN
cusj-6369	56	53	�	�	PROPN
cusj-6369	56	54	skrvskdwh	skrvskdwh	PROPN
cusj-6369	56	55	�	�	PROPN
cusj-6369	56	56	dfwlydwhg	dfwlydwhg	PROPN
cusj-6369	56	57	�	�	PROPN
cusj-6369	56	58	joxwdplqdvh	joxwdplqdvh	PROPN
cusj-6369	56	59	�	�	PROPN
cusj-6369	56	60	�	�	PROPN
cusj-6369	56	61	3$*	3$*	NUM
cusj-6369	56	62	�	�	PROPN
cusj-6369	56	63	�	�	PROPN
cusj-6369	56	64	�	�	PROPN
cusj-6369	56	65	�	�	PROPN
cusj-6369	56	66	5hvrux¿q	5hvrux¿q	NUM
cusj-6369	56	67	�	�	PROPN
cusj-6369	56	68	àxruhvcence	àxruhvcence	NOUN
cusj-6369	56	69	is	be	AUX
cusj-6369	56	70	a	a	DET
cusj-6369	56	71	measure	measure	NOUN
cusj-6369	56	72	of	of	ADP
cusj-6369	56	73	glutamate	glutamate	ADJ
cusj-6369	56	74	concentration	concentration	NOUN
cusj-6369	56	75	and	and	CCONJ
cusj-6369	56	76	,	,	PUNCT
cusj-6369	56	77	therefore	therefore	ADV
cusj-6369	56	78	,	,	PUNCT
cusj-6369	56	79	3$*	3$*	NUM
cusj-6369	56	80	�	�	PROPN
cusj-6369	56	81	dfwlylw\	dfwlylw\	NOUN
cusj-6369	56	82	�	�	PROPN
cusj-6369	56	83	�	�	PROPN
cusj-6369	56	84	0rgl¿hg	0rgl¿hg	PROPN
cusj-6369	56	85	�	�	PROPN
cusj-6369	56	86	iurp	iurp	PROPN
cusj-6369	56	87	�	�	PROPN
cusj-6369	56	88	0f(our\	0f(our\	PROPN
cusj-6369	56	89	�	�	PROPN
cusj-6369	56	90	hw	hw	NOUN
cusj-6369	56	91	�	�	PROPN
cusj-6369	56	92	do	do	AUX
cusj-6369	56	93	�	�	PROPN
cusj-6369	56	94	�	�	PROPN
cusj-6369	56	95	�	�	PROPN
cusj-6369	56	96	�	�	PROPN
cusj-6369	56	97	�	�	PROPN
cusj-6369	56	98	�	�	PROPN
cusj-6369	56	99	�	�	PROPN
cusj-6369	56	100	�	�	PROPN
cusj-6369	56	101	�	�	PROPN
cusj-6369	56	102	�	�	PROPN
cusj-6369	56	103	methods	method	NOUN
cusj-6369	56	104	varying	vary	VERB
cusj-6369	56	105	concentrations	concentration	NOUN
cusj-6369	56	106	.	.	PUNCT
cusj-6369	57	1	additionally	additionally	ADV
cusj-6369	57	2	,	,	PUNCT
cusj-6369	57	3	!	!	PUNCT
cusj-6369	58	1	uorescence	uorescence	NOUN
cusj-6369	58	2	readings	reading	NOUN
cusj-6369	58	3	were	be	AUX
cusj-6369	58	4	taken	take	VERB
cusj-6369	58	5	every	every	DET
cusj-6369	58	6	10	10	NUM
cusj-6369	58	7	minutes	minute	NOUN
cusj-6369	58	8	so	so	SCONJ
cusj-6369	58	9	that	that	SCONJ
cusj-6369	58	10	reaction	reaction	NOUN
cusj-6369	58	11	rates	rate	NOUN
cusj-6369	58	12	could	could	AUX
cusj-6369	58	13	be	be	AUX
cusj-6369	58	14	calculated	calculate	VERB
cusj-6369	58	15	based	base	VERB
cusj-6369	58	16	on	on	ADP
cusj-6369	58	17	the	the	DET
cusj-6369	58	18	slope	slope	NOUN
cusj-6369	58	19	of	of	ADP
cusj-6369	58	20	the	the	DET
cusj-6369	58	21	graph	graph	NOUN
cusj-6369	58	22	of	of	ADP
cusj-6369	58	23	!	!	PUNCT
cusj-6369	58	24	uorescence	uorescence	NOUN
cusj-6369	58	25	versus	versus	ADP
cusj-6369	58	26	time	time	NOUN
cusj-6369	58	27	.	.	PUNCT
cusj-6369	59	1	graphpad	graphpad	NOUN
cusj-6369	59	2	prism	prism	NOUN
cusj-6369	59	3	4	4	NUM
cusj-6369	59	4	was	be	AUX
cusj-6369	59	5	used	use	VERB
cusj-6369	59	6	to	to	PART
cusj-6369	59	7	transform	transform	VERB
cusj-6369	59	8	the	the	DET
cusj-6369	59	9	!	!	PUNCT
cusj-6369	59	10	uorescence	uorescence	NOUN
cusj-6369	59	11	data	datum	NOUN
cusj-6369	59	12	to	to	ADP
cusj-6369	59	13	"	"	PUNCT
cusj-6369	59	14	t	t	PROPN
cusj-6369	59	15	a	a	DET
cusj-6369	59	16	characteristic	characteristic	ADJ
cusj-6369	59	17	michaelis	michaelis	ADJ
cusj-6369	59	18	-	-	PUNCT
cusj-6369	59	19	menten	menten	ADJ
cusj-6369	59	20	curve	curve	NOUN
cusj-6369	59	21	and	and	CCONJ
cusj-6369	59	22	to	to	PART
cusj-6369	59	23	calculate	calculate	VERB
cusj-6369	59	24	the	the	DET
cusj-6369	59	25	ic50	ic50	PROPN
cusj-6369	59	26	value	value	NOUN
cusj-6369	59	27	for	for	ADP
cusj-6369	59	28	the	the	DET
cusj-6369	59	29	inhibitors	inhibitor	NOUN
cusj-6369	59	30	.	.	PUNCT
cusj-6369	60	1	ic50	ic50	PROPN
cusj-6369	60	2	is	be	AUX
cusj-6369	60	3	a	a	DET
cusj-6369	60	4	measure	measure	NOUN
cusj-6369	60	5	of	of	ADP
cusj-6369	60	6	inhibitory	inhibitory	ADJ
cusj-6369	60	7	power	power	NOUN
cusj-6369	60	8	;	;	PUNCT
cusj-6369	60	9	it	it	PRON
cusj-6369	60	10	is	be	AUX
cusj-6369	60	11	the	the	DET
cusj-6369	60	12	concentration	concentration	NOUN
cusj-6369	60	13	of	of	ADP
cusj-6369	60	14	inhibitor	inhibitor	NOUN
cusj-6369	60	15	at	at	ADP
cusj-6369	60	16	which	which	PRON
cusj-6369	60	17	the	the	DET
cusj-6369	60	18	reaction	reaction	NOUN
cusj-6369	60	19	rate	rate	NOUN
cusj-6369	60	20	catalyzed	catalyze	VERB
cusj-6369	60	21	by	by	ADP
cusj-6369	60	22	a	a	DET
cusj-6369	60	23	particular	particular	ADJ
cusj-6369	60	24	enzyme	enzyme	NOUN
cusj-6369	60	25	is	be	AUX
cusj-6369	60	26	halved	halve	VERB
cusj-6369	60	27	.	.	PUNCT
cusj-6369	61	1	#	#	SYM
cusj-6369	61	2	e	e	NOUN
cusj-6369	61	3	steps	step	NOUN
cusj-6369	61	4	in	in	ADP
cusj-6369	61	5	the	the	DET
cusj-6369	61	6	screening	screening	NOUN
cusj-6369	61	7	of	of	ADP
cusj-6369	61	8	the	the	DET
cusj-6369	61	9	chembridge	chembridge	NOUN
cusj-6369	61	10	cnsset	cnsset	NOUN
cusj-6369	61	11	library	library	NOUN
cusj-6369	61	12	are	be	AUX
cusj-6369	61	13	detailed	detail	VERB
cusj-6369	61	14	in	in	ADP
cusj-6369	61	15	figure	figure	NOUN
cusj-6369	61	16	3	3	NUM
cusj-6369	61	17	.	.	PUNCT
cusj-6369	61	18	a	a	DET
cusj-6369	61	19	visual	visual	ADJ
cusj-6369	61	20	basic	basic	ADJ
cusj-6369	61	21	loop	loop	NOUN
cusj-6369	61	22	program	program	NOUN
cusj-6369	61	23	was	be	AUX
cusj-6369	61	24	used	use	VERB
cusj-6369	61	25	to	to	PART
cusj-6369	61	26	rank	rank	VERB
cusj-6369	61	27	in	in	ADP
cusj-6369	61	28	descending	descend	VERB
cusj-6369	61	29	order	order	NOUN
cusj-6369	61	30	and	and	CCONJ
cusj-6369	61	31	in	in	ADP
cusj-6369	61	32	terms	term	NOUN
cusj-6369	61	33	of	of	ADP
cusj-6369	61	34	percent	percent	NOUN
cusj-6369	61	35	inhibition	inhibition	VERB
cusj-6369	61	36	the	the	DET
cusj-6369	61	37	320	320	NUM
cusj-6369	61	38	library	library	NOUN
cusj-6369	61	39	compounds	compound	NOUN
cusj-6369	61	40	on	on	ADP
cusj-6369	61	41	each	each	PRON
cusj-6369	61	42	of	of	ADP
cusj-6369	61	43	the	the	DET
cusj-6369	61	44	180	180	NUM
cusj-6369	61	45	plates	plate	NOUN
cusj-6369	61	46	.	.	PUNCT
cusj-6369	62	1	because	because	SCONJ
cusj-6369	62	2	of	of	ADP
cusj-6369	62	3	variability	variability	NOUN
cusj-6369	62	4	in	in	ADP
cusj-6369	62	5	!	!	PUNCT
cusj-6369	62	6	uorescence	uorescence	NOUN
cusj-6369	62	7	values	value	NOUN
cusj-6369	62	8	of	of	ADP
cusj-6369	62	9	the	the	DET
cusj-6369	62	10	controls	control	NOUN
cusj-6369	62	11	in	in	ADP
cusj-6369	62	12	di$erent	di$erent	ADJ
cusj-6369	62	13	plates	plate	NOUN
cusj-6369	62	14	,	,	PUNCT
cusj-6369	62	15	results	result	NOUN
cusj-6369	62	16	of	of	ADP
cusj-6369	62	17	the	the	DET
cusj-6369	62	18	primary	primary	ADJ
cusj-6369	62	19	screen	screen	NOUN
cusj-6369	62	20	were	be	AUX
cusj-6369	62	21	sorted	sort	VERB
cusj-6369	62	22	based	base	VERB
cusj-6369	62	23	on	on	ADP
cusj-6369	62	24	their	their	PRON
cusj-6369	62	25	dynamic	dynamic	ADJ
cusj-6369	62	26	range	range	NOUN
cusj-6369	62	27	.	.	PUNCT
cusj-6369	63	1	#	#	SYM
cusj-6369	63	2	e	e	PROPN
cusj-6369	63	3	dr	dr	NOUN
cusj-6369	63	4	of	of	ADP
cusj-6369	63	5	!	!	PUNCT
cusj-6369	63	6	uorescence	uorescence	NOUN
cusj-6369	63	7	for	for	SCONJ
cusj-6369	63	8	a	a	DET
cusj-6369	63	9	particular	particular	ADJ
cusj-6369	63	10	plate	plate	NOUN
cusj-6369	63	11	was	be	AUX
cusj-6369	63	12	de"ned	de"ne	VERB
cusj-6369	63	13	using	use	VERB
cusj-6369	63	14	the	the	DET
cusj-6369	63	15	control	control	NOUN
cusj-6369	63	16	!	!	PUNCT
cusj-6369	64	1	uorescence	uorescence	NOUN
cusj-6369	64	2	values	value	NOUN
cusj-6369	64	3	:	:	PUNCT
cusj-6369	64	4	dr	dr	PROPN
cusj-6369	64	5	=	=	PROPN
cusj-6369	64	6	100	100	NUM
cusj-6369	64	7	%	%	NOUN
cusj-6369	64	8	*	*	PUNCT
cusj-6369	64	9	(	(	PUNCT
cusj-6369	64	10	positive	positive	ADJ
cusj-6369	64	11	control	control	NOUN
cusj-6369	64	12	negative	negative	ADJ
cusj-6369	64	13	control	control	NOUN
cusj-6369	64	14	)	)	PUNCT
cusj-6369	64	15	(	(	PUNCT
cusj-6369	64	16	positive	positive	ADJ
cusj-6369	64	17	control	control	NOUN
cusj-6369	64	18	)	)	PUNCT
cusj-6369	64	19	plates	plate	NOUN
cusj-6369	64	20	were	be	AUX
cusj-6369	64	21	then	then	ADV
cusj-6369	64	22	placed	place	VERB
cusj-6369	64	23	into	into	ADP
cusj-6369	64	24	three	three	NUM
cusj-6369	64	25	categories	category	NOUN
cusj-6369	64	26	:	:	PUNCT
cusj-6369	64	27	good	good	ADJ
cusj-6369	64	28	secondary	secondary	ADJ
cusj-6369	64	29	screen	screen	NOUN
cusj-6369	64	30	to	to	PART
cusj-6369	64	31	select	select	VERB
cusj-6369	64	32	true	true	ADJ
cusj-6369	64	33	inhibitors	inhibitor	NOUN
cusj-6369	64	34	of	of	ADP
cusj-6369	64	35	pag	pag	PROPN
cusj-6369	64	36	,	,	PUNCT
cusj-6369	64	37	it	it	PRON
cusj-6369	64	38	was	be	AUX
cusj-6369	64	39	necessary	necessary	ADJ
cusj-6369	64	40	to	to	PART
cusj-6369	64	41	eliminate	eliminate	VERB
cusj-6369	64	42	the	the	DET
cusj-6369	64	43	hits	hit	NOUN
cusj-6369	64	44	that	that	PRON
cusj-6369	64	45	were	be	AUX
cusj-6369	64	46	inhibitors	inhibitor	NOUN
cusj-6369	64	47	of	of	ADP
cusj-6369	64	48	the	the	DET
cusj-6369	64	49	kit	kit	NOUN
cusj-6369	64	50	enzymes	enzyme	NOUN
cusj-6369	64	51	go	go	VERB
cusj-6369	64	52	and	and	CCONJ
cusj-6369	64	53	hrp	hrp	PROPN
cusj-6369	64	54	.	.	PUNCT
cusj-6369	65	1	to	to	PART
cusj-6369	65	2	eliminate	eliminate	VERB
cusj-6369	65	3	go	go	VERB
cusj-6369	65	4	/	/	SYM
cusj-6369	65	5	hrp	hrp	NOUN
cusj-6369	65	6	inhibitors	inhibitor	NOUN
cusj-6369	65	7	,	,	PUNCT
cusj-6369	65	8	another	another	DET
cusj-6369	65	9	resoru"n	resoru"n	NOUN
cusj-6369	65	10	assay	assay	PROPN
cusj-6369	65	11	was	be	AUX
cusj-6369	65	12	designed	design	VERB
cusj-6369	65	13	for	for	ADP
cusj-6369	65	14	this	this	DET
cusj-6369	65	15	purpose	purpose	NOUN
cusj-6369	65	16	.	.	PUNCT
cusj-6369	66	1	#	#	NOUN
cusj-6369	66	2	is	be	AUX
cusj-6369	66	3	assay	assay	NOUN
cusj-6369	66	4	was	be	AUX
cusj-6369	66	5	similar	similar	ADJ
cusj-6369	66	6	to	to	ADP
cusj-6369	66	7	the	the	DET
cusj-6369	66	8	original	original	ADJ
cusj-6369	66	9	glutamine	glutamine	NOUN
cusj-6369	66	10	-	-	PUNCT
cusj-6369	66	11	glutamate	glutamate	NOUN
cusj-6369	66	12	amplex	amplex	NOUN
cusj-6369	66	13	red	red	ADJ
cusj-6369	66	14	assay	assay	PROPN
cusj-6369	66	15	except	except	SCONJ
cusj-6369	66	16	that	that	DET
cusj-6369	66	17	glutamine	glutamine	NOUN
cusj-6369	66	18	was	be	AUX
cusj-6369	66	19	replaced	replace	VERB
cusj-6369	66	20	by	by	ADP
cusj-6369	66	21	the	the	DET
cusj-6369	66	22	go/	go/	ADJ
cusj-6369	66	23	hrp	hrp	PROPN
cusj-6369	66	24	substrate	substrate	NOUN
cusj-6369	66	25	glutamic	glutamic	ADJ
cusj-6369	66	26	acid	acid	NOUN
cusj-6369	66	27	,	,	PUNCT
cusj-6369	66	28	and	and	CCONJ
cusj-6369	66	29	pag	pag	PROPN
cusj-6369	66	30	was	be	AUX
cusj-6369	66	31	not	not	PART
cusj-6369	66	32	included	include	VERB
cusj-6369	66	33	.	.	PUNCT
cusj-6369	67	1	because	because	SCONJ
cusj-6369	67	2	the	the	DET
cusj-6369	67	3	conversion	conversion	NOUN
cusj-6369	67	4	of	of	ADP
cusj-6369	67	5	glutamate	glutamate	NOUN
cusj-6369	67	6	to	to	PART
cusj-6369	67	7	resoru"n	resoru"n	VERB
cusj-6369	67	8	is	be	AUX
cusj-6369	67	9	much	much	ADV
cusj-6369	67	10	faster	fast	ADJ
cusj-6369	67	11	than	than	ADP
cusj-6369	67	12	pag	pag	NOUN
cusj-6369	67	13	-	-	PUNCT
cusj-6369	67	14	catalyzed	catalyze	VERB
cusj-6369	67	15	glutamine	glutamine	NOUN
cusj-6369	67	16	deamination	deamination	NOUN
cusj-6369	67	17	,	,	PUNCT
cusj-6369	67	18	it	it	PRON
cusj-6369	67	19	was	be	AUX
cusj-6369	67	20	necessary	necessary	ADJ
cusj-6369	67	21	to	to	PART
cusj-6369	67	22	determine	determine	VERB
cusj-6369	67	23	optimal	optimal	ADJ
cusj-6369	67	24	substrate	substrate	NOUN
cusj-6369	67	25	and	and	CCONJ
cusj-6369	67	26	enzyme	enzyme	NOUN
cusj-6369	67	27	concentrations	concentration	NOUN
cusj-6369	67	28	that	that	PRON
cusj-6369	67	29	would	would	AUX
cusj-6369	67	30	produce	produce	VERB
cusj-6369	67	31	a	a	DET
cusj-6369	67	32	linear	linear	ADJ
cusj-6369	67	33	increase	increase	NOUN
cusj-6369	67	34	in	in	ADP
cusj-6369	67	35	product	product	NOUN
cusj-6369	67	36	over	over	ADP
cusj-6369	67	37	a	a	DET
cusj-6369	67	38	given	give	VERB
cusj-6369	67	39	time	time	NOUN
cusj-6369	67	40	frame	frame	NOUN
cusj-6369	67	41	.	.	PUNCT
cusj-6369	68	1	based	base	VERB
cusj-6369	68	2	on	on	ADP
cusj-6369	68	3	a	a	DET
cusj-6369	68	4	preliminary	preliminary	ADJ
cusj-6369	68	5	kinetics	kinetic	NOUN
cusj-6369	68	6	assay	assay	VERB
cusj-6369	68	7	,	,	PUNCT
cusj-6369	68	8	it	it	PRON
cusj-6369	68	9	was	be	AUX
cusj-6369	68	10	determined	determine	VERB
cusj-6369	68	11	that	that	SCONJ
cusj-6369	68	12	replacing	replace	VERB
cusj-6369	68	13	the	the	DET
cusj-6369	68	14	40	40	NUM
cusj-6369	68	15	µm	µm	NOUN
cusj-6369	68	16	glutamine	glutamine	NOUN
cusj-6369	68	17	with	with	ADP
cusj-6369	68	18	10	10	NUM
cusj-6369	68	19	µm	µm	NOUN
cusj-6369	68	20	glutamic	glutamic	ADJ
cusj-6369	68	21	acid	acid	NOUN
cusj-6369	68	22	and	and	CCONJ
cusj-6369	68	23	maintaining	maintain	VERB
cusj-6369	68	24	previous	previous	ADJ
cusj-6369	68	25	kit	kit	NOUN
cusj-6369	68	26	enzyme	enzyme	NOUN
cusj-6369	68	27	concentrations	concentration	NOUN
cusj-6369	68	28	produced	produce	VERB
cusj-6369	68	29	a	a	DET
cusj-6369	68	30	reaction	reaction	NOUN
cusj-6369	68	31	where	where	SCONJ
cusj-6369	68	32	the	the	DET
cusj-6369	68	33	concentration	concentration	NOUN
cusj-6369	68	34	of	of	ADP
cusj-6369	68	35	product	product	NOUN
cusj-6369	68	36	(	(	PUNCT
cusj-6369	68	37	resoru"n	resoru"n	NOUN
cusj-6369	68	38	)	)	PUNCT
cusj-6369	68	39	increased	increase	VERB
cusj-6369	68	40	linearly	linearly	ADV
cusj-6369	68	41	with	with	ADP
cusj-6369	68	42	time	time	NOUN
cusj-6369	68	43	(	(	PUNCT
cusj-6369	68	44	and	and	CCONJ
cusj-6369	68	45	did	do	AUX
cusj-6369	68	46	not	not	PART
cusj-6369	68	47	saturate	saturate	VERB
cusj-6369	68	48	)	)	PUNCT
cusj-6369	68	49	.	.	PUNCT
cusj-6369	69	1	once	once	ADV
cusj-6369	69	2	the	the	DET
cusj-6369	69	3	glutamic	glutamic	ADJ
cusj-6369	69	4	acid	acid	NOUN
cusj-6369	69	5	assay	assay	NOUN
cusj-6369	69	6	parameters	parameter	NOUN
cusj-6369	69	7	were	be	AUX
cusj-6369	69	8	determined	determine	VERB
cusj-6369	69	9	,	,	PUNCT
cusj-6369	69	10	the	the	DET
cusj-6369	69	11	primary	primary	ADJ
cusj-6369	69	12	screen	screen	NOUN
cusj-6369	69	13	assay	assay	PROPN
cusj-6369	69	14	and	and	CCONJ
cusj-6369	69	15	glutamic	glutamic	ADJ
cusj-6369	69	16	acid	acid	NOUN
cusj-6369	69	17	assay	assay	NOUN
cusj-6369	69	18	were	be	AUX
cusj-6369	69	19	carried	carry	VERB
cusj-6369	69	20	out	out	ADP
cusj-6369	69	21	in	in	ADP
cusj-6369	69	22	parallel	parallel	NOUN
cusj-6369	69	23	on	on	ADP
cusj-6369	69	24	the	the	DET
cusj-6369	69	25	primary	primary	ADJ
cusj-6369	69	26	screen	screen	NOUN
cusj-6369	69	27	hits	hit	VERB
cusj-6369	69	28	.	.	PUNCT
cusj-6369	70	1	percent	percent	NOUN
cusj-6369	70	2	inhibition	inhibition	NOUN
cusj-6369	70	3	of	of	ADP
cusj-6369	70	4	pag	pag	PROPN
cusj-6369	70	5	,	,	PUNCT
cusj-6369	70	6	go	go	VERB
cusj-6369	70	7	,	,	PUNCT
cusj-6369	70	8	and	and	CCONJ
cusj-6369	70	9	hrp	hrp	PROPN
cusj-6369	70	10	(	(	PUNCT
cusj-6369	70	11	primary	primary	ADJ
cusj-6369	70	12	screen	screen	NOUN
cusj-6369	70	13	)	)	PUNCT
cusj-6369	70	14	and	and	CCONJ
cusj-6369	70	15	of	of	ADP
cusj-6369	70	16	go	go	VERB
cusj-6369	70	17	and	and	CCONJ
cusj-6369	70	18	hrp	hrp	PROPN
cusj-6369	70	19	(	(	PUNCT
cusj-6369	70	20	glutamaic	glutamaic	PROPN
cusj-6369	70	21	acid	acid	PROPN
cusj-6369	70	22	assay	assay	PROPN
cusj-6369	70	23	)	)	PUNCT
cusj-6369	70	24	were	be	AUX
cusj-6369	70	25	determined	determine	VERB
cusj-6369	70	26	for	for	ADP
cusj-6369	70	27	each	each	DET
cusj-6369	70	28	hit	hit	NOUN
cusj-6369	70	29	,	,	PUNCT
cusj-6369	70	30	and	and	CCONJ
cusj-6369	70	31	percent	percent	NOUN
cusj-6369	70	32	inhibition	inhibition	NOUN
cusj-6369	70	33	of	of	ADP
cusj-6369	70	34	pag	pag	PROPN
cusj-6369	70	35	only	only	ADV
cusj-6369	70	36	was	be	AUX
cusj-6369	70	37	calculated	calculate	VERB
cusj-6369	70	38	by	by	ADP
cusj-6369	70	39	subtracting	subtract	VERB
cusj-6369	70	40	go	go	NOUN
cusj-6369	70	41	/	/	SYM
cusj-6369	70	42	hrp	hrp	NOUN
cusj-6369	70	43	inhibition	inhibition	NOUN
cusj-6369	70	44	from	from	ADP
cusj-6369	70	45	pag/	pag/	ADJ
cusj-6369	70	46	go	go	VERB
cusj-6369	70	47	/	/	SYM
cusj-6369	70	48	hrp	hrp	NOUN
cusj-6369	70	49	inhibition	inhibition	NOUN
cusj-6369	70	50	.	.	PUNCT
cusj-6369	71	1	‘	'	PUNCT
cusj-6369	71	2	hit	hit	VERB
cusj-6369	71	3	’	'	PUNCT
cusj-6369	71	4	kinetics	kinetic	VERB
cusj-6369	71	5	analysis	analysis	NOUN
cusj-6369	71	6	of	of	ADP
cusj-6369	71	7	the	the	DET
cusj-6369	71	8	compounds	compound	NOUN
cusj-6369	71	9	that	that	PRON
cusj-6369	71	10	were	be	AUX
cusj-6369	71	11	picked	pick	VERB
cusj-6369	71	12	up	up	ADP
cusj-6369	71	13	in	in	ADP
cusj-6369	71	14	the	the	DET
cusj-6369	71	15	secondary	secondary	ADJ
cusj-6369	71	16	screen	screen	NOUN
cusj-6369	71	17	,	,	PUNCT
cusj-6369	71	18	the	the	DET
cusj-6369	71	19	ten	ten	NUM
cusj-6369	71	20	with	with	ADP
cusj-6369	71	21	the	the	DET
cusj-6369	71	22	highest	high	ADJ
cusj-6369	71	23	percent	percent	NOUN
cusj-6369	71	24	pag	pag	NOUN
cusj-6369	71	25	inhibition	inhibition	NOUN
cusj-6369	71	26	were	be	AUX
cusj-6369	71	27	selected	select	VERB
cusj-6369	71	28	for	for	ADP
cusj-6369	71	29	kinetic	kinetic	ADJ
cusj-6369	71	30	analysis	analysis	NOUN
cusj-6369	71	31	and	and	CCONJ
cusj-6369	71	32	purchased	purchase	VERB
cusj-6369	71	33	from	from	ADP
cusj-6369	71	34	chembridge	chembridge	NOUN
cusj-6369	71	35	.	.	PUNCT
cusj-6369	72	1	0.1	0.1	NUM
cusj-6369	72	2	m	m	VERB
cusj-6369	72	3	aliquots	aliquot	NOUN
cusj-6369	72	4	of	of	ADP
cusj-6369	72	5	each	each	DET
cusj-6369	72	6	compound	compound	NOUN
cusj-6369	72	7	were	be	AUX
cusj-6369	72	8	prepared	prepare	VERB
cusj-6369	72	9	with	with	ADP
cusj-6369	72	10	dmso	dmso	NOUN
cusj-6369	72	11	and	and	CCONJ
cusj-6369	72	12	stored	store	VERB
cusj-6369	72	13	at	at	ADP
cusj-6369	72	14	-80oc	-80oc	PROPN
cusj-6369	72	15	.	.	PUNCT
cusj-6369	73	1	from	from	ADP
cusj-6369	73	2	these	these	DET
cusj-6369	73	3	stock	stock	NOUN
cusj-6369	73	4	solutions	solution	NOUN
cusj-6369	73	5	,	,	PUNCT
cusj-6369	73	6	10	10	NUM
cusj-6369	73	7	-	-	ADJ
cusj-6369	73	8	fold	fold	ADJ
cusj-6369	73	9	dilution	dilution	NOUN
cusj-6369	73	10	series	series	NOUN
cusj-6369	73	11	ranging	range	VERB
cusj-6369	73	12	from	from	ADP
cusj-6369	73	13	10	10	NUM
cusj-6369	73	14	-	-	SYM
cusj-6369	73	15	3	3	NUM
cusj-6369	73	16	m	m	NOUN
cusj-6369	73	17	to	to	ADP
cusj-6369	73	18	10	10	NUM
cusj-6369	73	19	-	-	SYM
cusj-6369	73	20	8	8	NUM
cusj-6369	73	21	m	m	NOUN
cusj-6369	73	22	were	be	AUX
cusj-6369	73	23	prepared	prepare	VERB
cusj-6369	73	24	for	for	ADP
cusj-6369	73	25	each	each	DET
cusj-6369	73	26	compound	compound	NOUN
cusj-6369	73	27	.	.	PUNCT
cusj-6369	74	1	#	#	SYM
cusj-6369	74	2	e	e	NOUN
cusj-6369	74	3	same	same	ADJ
cusj-6369	74	4	assay	assay	NOUN
cusj-6369	74	5	that	that	PRON
cusj-6369	74	6	was	be	AUX
cusj-6369	74	7	used	use	VERB
cusj-6369	74	8	in	in	ADP
cusj-6369	74	9	the	the	DET
cusj-6369	74	10	primary	primary	ADJ
cusj-6369	74	11	screen	screen	NOUN
cusj-6369	74	12	was	be	AUX
cusj-6369	74	13	used	use	VERB
cusj-6369	74	14	for	for	ADP
cusj-6369	74	15	the	the	DET
cusj-6369	74	16	kinetics	kinetic	NOUN
cusj-6369	74	17	analysis	analysis	NOUN
cusj-6369	74	18	experiment	experiment	NOUN
cusj-6369	74	19	,	,	PUNCT
cusj-6369	74	20	except	except	SCONJ
cusj-6369	74	21	that	that	SCONJ
cusj-6369	74	22	the	the	DET
cusj-6369	74	23	inhibitors	inhibitor	NOUN
cusj-6369	74	24	were	be	AUX
cusj-6369	74	25	used	use	VERB
cusj-6369	74	26	in	in	ADP
cusj-6369	74	27	columbia	columbia	PROPN
cusj-6369	74	28	undergraduate	undergraduate	PROPN
cusj-6369	74	29	science	science	PROPN
cusj-6369	74	30	journal	journal	PROPN
cusj-6369	74	31	open	open	ADJ
cusj-6369	74	32	-	-	PUNCT
cusj-6369	74	33	access	access	NOUN
cusj-6369	74	34	publication	publication	NOUN
cusj-6369	74	35	|	|	ADV
cusj-6369	74	36	http://cusj.columbia.edu	http://cusj.columbia.edu	X
cusj-6369	75	1	5	5	NUM
cusj-6369	75	2	cusjvolume	cusjvolume	ADJ
cusj-6369	75	3	6spring	6spring	NUM
cusj-6369	75	4	2012	2012	NUM
cusj-6369	75	5	columbia	columbia	PROPN
cusj-6369	75	6	undergraduate	undergraduate	NOUN
cusj-6369	75	7	sci	sci	PROPN
cusj-6369	75	8	j	j	PROPN
cusj-6369	75	9	http://cusj.columbia.edu	http://cusj.columbia.edu	PROPN
cusj-6369	76	1	p	p	X
cusj-6369	76	2	s	s	X
cusj-6369	76	3	y	y	PROPN
cusj-6369	76	4	c	c	PROPN
cusj-6369	76	5	h	h	PROPN
cusj-6369	76	6	ia	ia	PROPN
cusj-6369	76	7	tr	tr	PROPN
cusj-6369	76	8	y	y	PROPN
cusj-6369	76	9	cusjcolumbia	cusjcolumbia	ADJ
cusj-6369	76	10	undergraduate	undergraduate	NOUN
cusj-6369	76	11	science	science	PROPN
cusj-6369	76	12	journal	journal	PROPN
cusj-6369	76	13	research	research	NOUN
cusj-6369	76	14	articles	article	NOUN
cusj-6369	77	1	6cusj	6cusj	NUM
cusj-6369	77	2	volume	volume	NOUN
cusj-6369	77	3	6spring	6spring	NUM
cusj-6369	77	4	2012	2012	NUM
cusj-6369	77	5	columbia	columbia	PROPN
cusj-6369	77	6	undergraduate	undergraduate	NOUN
cusj-6369	77	7	http://cusj.columbia.edu	http://cusj.columbia.edu	NOUN
cusj-6369	77	8	figure	figure	NOUN
cusj-6369	77	9	2	2	NUM
cusj-6369	77	10	a	a	DET
cusj-6369	77	11	typical	typical	ADJ
cusj-6369	77	12	plate	plate	NOUN
cusj-6369	77	13	from	from	ADP
cusj-6369	77	14	the	the	DET
cusj-6369	77	15	primary	primary	ADJ
cusj-6369	77	16	screen	screen	NOUN
cusj-6369	77	17	.	.	PUNCT
cusj-6369	78	1	figure	figure	VERB
cusj-6369	78	2	4	4	NUM
cusj-6369	78	3	reaction	reaction	NOUN
cusj-6369	78	4	rate	rate	NOUN
cusj-6369	78	5	vs.	vs.	ADP
cusj-6369	78	6	concentration	concentration	NOUN
cusj-6369	78	7	plotted	plot	VERB
cusj-6369	78	8	using	use	VERB
cusj-6369	78	9	prism	prism	NOUN
cusj-6369	78	10	software	software	NOUN
cusj-6369	78	11	.	.	PUNCT
cusj-6369	79	1	ic	ic	PROPN
cusj-6369	79	2	�	�	PROPN
cusj-6369	79	3	�	�	PROPN
cusj-6369	79	4	�	�	PROPN
cusj-6369	79	5	values	value	NOUN
cusj-6369	79	6	are	be	AUX
cusj-6369	79	7	displayed	display	VERB
cusj-6369	79	8	in	in	ADP
cusj-6369	79	9	the	the	DET
cusj-6369	79	10	table	table	NOUN
cusj-6369	79	11	to	to	ADP
cusj-6369	79	12	the	the	DET
cusj-6369	79	13	right	right	ADJ
cusj-6369	79	14	figure	figure	NOUN
cusj-6369	79	15	3	3	NUM
cusj-6369	79	16	$	$	SYM
cusj-6369	79	17	�	�	PROPN
cusj-6369	79	18	vfkhpdwlf	vfkhpdwlf	PROPN
cusj-6369	79	19	�	�	PROPN
cusj-6369	79	20	gldjudp	gldjudp	NOUN
cusj-6369	79	21	�	�	PROPN
cusj-6369	79	22	rxwolqlqj	rxwolqlqj	PROPN
cusj-6369	79	23	�	�	PROPN
cusj-6369	79	24	wkh	wkh	PROPN
cusj-6369	79	25	�	�	PROPN
cusj-6369	79	26	vfuhhqlqj	vfuhhqlqj	PROPN
cusj-6369	79	27	�	�	PROPN
cusj-6369	79	28	surfhvv	surfhvv	PROPN
cusj-6369	79	29	�	�	PROPN
cusj-6369	79	30	iru	iru	PROPN
cusj-6369	79	31	�	�	PROPN
cusj-6369	79	32	wkh	wkh	PROPN
cusj-6369	79	33	�	�	PROPN
cusj-6369	79	34	vhohfwlrq	vhohfwlrq	PROPN
cusj-6369	79	35	�	�	PROPN
cusj-6369	79	36	ri	ri	PROPN
cusj-6369	79	37	�	�	PROPN
cusj-6369	79	38	3$*	3$*	NUM
cusj-6369	79	39	�	�	PROPN
cusj-6369	79	40	vshfl¿f	vshfl¿f	PROPN
cusj-6369	79	41	�	�	PROPN
cusj-6369	79	42	lqklelwruv	lqklelwruv	PROPN
cusj-6369	79	43	p	p	PROPN
cusj-6369	79	44	s	s	PROPN
cusj-6369	79	45	y	y	PROPN
cusj-6369	79	46	c	c	NOUN
cusj-6369	79	47	h	h	NOUN
cusj-6369	79	48	iatr	iatr	VERB
cusj-6369	79	49	y	y	PROPN
cusj-6369	79	50	trial	trial	NOUN
cusj-6369	79	51	1	1	NUM
cusj-6369	79	52	2	2	NUM
cusj-6369	79	53	3	3	NUM
cusj-6369	79	54	4	4	NUM
cusj-6369	79	55	average	average	ADJ
cusj-6369	79	56	±	±	X
cusj-6369	79	57	se	se	X
cusj-6369	80	1	ic50	ic50	PROPN
cusj-6369	80	2	(	(	PUNCT
cusj-6369	80	3	um	um	INTJ
cusj-6369	80	4	)	)	PUNCT
cusj-6369	80	5	5.482	5.482	NUM
cusj-6369	80	6	3.647	3.647	NUM
cusj-6369	80	7	4.655	4.655	NUM
cusj-6369	80	8	3.303	3.303	NUM
cusj-6369	80	9	4.272	4.272	NUM
cusj-6369	80	10	±	±	NOUN
cusj-6369	80	11	0.572	0.572	NUM
cusj-6369	80	12	r2	r2	NOUN
cusj-6369	80	13	0.951	0.951	NUM
cusj-6369	80	14	0.982	0.982	NUM
cusj-6369	80	15	0.944	0.944	NUM
cusj-6369	80	16	0.956	0.956	NUM
cusj-6369	80	17	(	(	PUNCT
cusj-6369	80	18	dr=95	dr=95	NOUN
cusj-6369	80	19	-	-	PUNCT
cusj-6369	80	20	50	50	NUM
cusj-6369	80	21	%	%	NOUN
cusj-6369	80	22	)	)	PUNCT
cusj-6369	80	23	,	,	PUNCT
cusj-6369	80	24	low	low	ADJ
cusj-6369	80	25	or	or	CCONJ
cusj-6369	80	26	extreme	extreme	ADJ
cusj-6369	80	27	(	(	PUNCT
cusj-6369	80	28	dr<50	dr<50	NOUN
cusj-6369	80	29	%	%	NOUN
cusj-6369	80	30	or	or	CCONJ
cusj-6369	80	31	dr>95	dr>95	NUM
cusj-6369	80	32	%	%	NOUN
cusj-6369	80	33	)	)	PUNCT
cusj-6369	80	34	,	,	PUNCT
cusj-6369	80	35	and	and	CCONJ
cusj-6369	80	36	poor	poor	ADJ
cusj-6369	80	37	dynamic	dynamic	ADJ
cusj-6369	80	38	range	range	NOUN
cusj-6369	80	39	(	(	PUNCT
cusj-6369	80	40	dr!0	dr!0	X
cusj-6369	80	41	%	%	NOUN
cusj-6369	80	42	)	)	PUNCT
cusj-6369	80	43	.	.	PUNCT
cusj-6369	81	1	for	for	ADP
cusj-6369	81	2	plates	plate	NOUN
cusj-6369	81	3	with	with	ADP
cusj-6369	81	4	a	a	DET
cusj-6369	81	5	good	good	ADJ
cusj-6369	81	6	dynamic	dynamic	ADJ
cusj-6369	81	7	range	range	NOUN
cusj-6369	81	8	,	,	PUNCT
cusj-6369	81	9	compounds	compound	VERB
cusj-6369	81	10	that	that	PRON
cusj-6369	81	11	exhibited	exhibit	VERB
cusj-6369	81	12	at	at	ADV
cusj-6369	81	13	least	least	ADV
cusj-6369	81	14	90	90	NUM
cusj-6369	81	15	%	%	NOUN
cusj-6369	81	16	inhibition	inhibition	NOUN
cusj-6369	81	17	were	be	AUX
cusj-6369	81	18	selected	select	VERB
cusj-6369	81	19	.	.	PUNCT
cusj-6369	82	1	for	for	ADP
cusj-6369	82	2	plates	plate	NOUN
cusj-6369	82	3	with	with	ADP
cusj-6369	82	4	a	a	DET
cusj-6369	82	5	low	low	ADJ
cusj-6369	82	6	or	or	CCONJ
cusj-6369	82	7	extreme	extreme	ADJ
cusj-6369	82	8	dynamic	dynamic	ADJ
cusj-6369	82	9	range	range	NOUN
cusj-6369	82	10	or	or	CCONJ
cusj-6369	82	11	non	non	ADJ
cusj-6369	82	12	-	-	ADJ
cusj-6369	82	13	existent	existent	ADJ
cusj-6369	82	14	dynamic	dynamic	ADJ
cusj-6369	82	15	range	range	NOUN
cusj-6369	82	16	,	,	PUNCT
cusj-6369	82	17	compounds	compound	NOUN
cusj-6369	82	18	were	be	AUX
cusj-6369	82	19	selected	select	VERB
cusj-6369	82	20	if	if	SCONJ
cusj-6369	82	21	they	they	PRON
cusj-6369	82	22	stood	stand	VERB
cusj-6369	82	23	out	out	ADP
cusj-6369	82	24	in	in	ADP
cusj-6369	82	25	the	the	DET
cusj-6369	82	26	plate	plate	NOUN
cusj-6369	82	27	distribution	distribution	NOUN
cusj-6369	82	28	.	.	PUNCT
cusj-6369	83	1	representative	representative	ADJ
cusj-6369	83	2	distributions	distribution	NOUN
cusj-6369	83	3	of	of	ADP
cusj-6369	83	4	compound	compound	NOUN
cusj-6369	83	5	inhibition	inhibition	NOUN
cusj-6369	83	6	data	datum	NOUN
cusj-6369	83	7	for	for	ADP
cusj-6369	83	8	three	three	NUM
cusj-6369	83	9	plates	plate	NOUN
cusj-6369	83	10	in	in	ADP
cusj-6369	83	11	each	each	PRON
cusj-6369	83	12	of	of	ADP
cusj-6369	83	13	the	the	DET
cusj-6369	83	14	three	three	NUM
cusj-6369	83	15	categories	category	NOUN
cusj-6369	83	16	are	be	AUX
cusj-6369	83	17	shown	show	VERB
cusj-6369	83	18	in	in	ADP
cusj-6369	83	19	figure	figure	NOUN
cusj-6369	83	20	4	4	NUM
cusj-6369	83	21	.	.	PUNCT
cusj-6369	83	22	for	for	ADP
cusj-6369	83	23	plates	plate	NOUN
cusj-6369	83	24	with	with	ADP
cusj-6369	83	25	a	a	DET
cusj-6369	83	26	good	good	ADJ
cusj-6369	83	27	dynamic	dynamic	ADJ
cusj-6369	83	28	range	range	NOUN
cusj-6369	83	29	,	,	PUNCT
cusj-6369	83	30	there	there	PRON
cusj-6369	83	31	were	be	VERB
cusj-6369	83	32	typically	typically	ADV
cusj-6369	83	33	very	very	ADV
cusj-6369	83	34	few	few	ADJ
cusj-6369	83	35	or	or	CCONJ
cusj-6369	83	36	no	no	PRON
cusj-6369	83	37	compounds	compound	NOUN
cusj-6369	83	38	with	with	ADP
cusj-6369	83	39	percent	percent	NOUN
cusj-6369	83	40	inhibition	inhibition	NOUN
cusj-6369	83	41	above	above	ADP
cusj-6369	83	42	90	90	NUM
cusj-6369	83	43	%	%	NOUN
cusj-6369	83	44	;	;	PUNCT
cusj-6369	83	45	however	however	ADV
cusj-6369	83	46	,	,	PUNCT
cusj-6369	83	47	for	for	ADP
cusj-6369	83	48	plates	plate	NOUN
cusj-6369	83	49	with	with	ADP
cusj-6369	83	50	a	a	DET
cusj-6369	83	51	low	low	ADJ
cusj-6369	83	52	or	or	CCONJ
cusj-6369	83	53	extreme	extreme	ADJ
cusj-6369	83	54	dynamic	dynamic	ADJ
cusj-6369	83	55	range	range	NOUN
cusj-6369	83	56	or	or	CCONJ
cusj-6369	83	57	a	a	DET
cusj-6369	83	58	poor	poor	ADJ
cusj-6369	83	59	dynamic	dynamic	ADJ
cusj-6369	83	60	range	range	NOUN
cusj-6369	83	61	,	,	PUNCT
cusj-6369	83	62	there	there	PRON
cusj-6369	83	63	were	be	VERB
cusj-6369	83	64	signi"cantly	signi"cantly	ADV
cusj-6369	83	65	more	more	ADJ
cusj-6369	83	66	compounds	compound	NOUN
cusj-6369	83	67	whose	whose	DET
cusj-6369	83	68	percent	percent	NOUN
cusj-6369	83	69	inhibition	inhibition	NOUN
cusj-6369	83	70	was	be	AUX
cusj-6369	83	71	greater	great	ADJ
cusj-6369	83	72	than	than	ADP
cusj-6369	83	73	90	90	NUM
cusj-6369	83	74	%	%	NOUN
cusj-6369	83	75	,	,	PUNCT
cusj-6369	83	76	and	and	CCONJ
cusj-6369	83	77	in	in	ADP
cusj-6369	83	78	fact	fact	NOUN
cusj-6369	83	79	,	,	PUNCT
cusj-6369	83	80	there	there	PRON
cusj-6369	83	81	were	be	VERB
cusj-6369	83	82	a	a	DET
cusj-6369	83	83	signi"cant	signi"cant	ADJ
cusj-6369	83	84	number	number	NOUN
cusj-6369	83	85	of	of	ADP
cusj-6369	83	86	compounds	compound	NOUN
cusj-6369	83	87	with	with	ADP
cusj-6369	83	88	percent	percent	NOUN
cusj-6369	83	89	inhibition	inhibition	NOUN
cusj-6369	83	90	greater	great	ADJ
cusj-6369	83	91	than	than	ADP
cusj-6369	83	92	100	100	NUM
cusj-6369	83	93	%	%	NOUN
cusj-6369	83	94	.	.	PUNCT
cusj-6369	84	1	#	#	SYM
cusj-6369	84	2	e	e	NOUN
cusj-6369	84	3	hits	hit	NOUN
cusj-6369	84	4	picked	pick	VERB
cusj-6369	84	5	up	up	ADP
cusj-6369	84	6	by	by	ADP
cusj-6369	84	7	this	this	DET
cusj-6369	84	8	process	process	NOUN
cusj-6369	84	9	were	be	AUX
cusj-6369	84	10	tested	test	VERB
cusj-6369	84	11	in	in	ADP
cusj-6369	84	12	the	the	DET
cusj-6369	84	13	secondary	secondary	ADJ
cusj-6369	84	14	screen	screen	NOUN
cusj-6369	84	15	to	to	PART
cusj-6369	84	16	eliminate	eliminate	VERB
cusj-6369	84	17	inhibitors	inhibitor	NOUN
cusj-6369	84	18	of	of	ADP
cusj-6369	84	19	go	go	VERB
cusj-6369	84	20	and	and	CCONJ
cusj-6369	84	21	hrp	hrp	PROPN
cusj-6369	84	22	.	.	PUNCT
cusj-6369	85	1	#	#	SYM
cusj-6369	85	2	e	e	NOUN
cusj-6369	85	3	compounds	compound	NOUN
cusj-6369	85	4	that	that	PRON
cusj-6369	85	5	had	have	VERB
cusj-6369	85	6	the	the	DET
cusj-6369	85	7	least	least	ADJ
cusj-6369	85	8	impact	impact	NOUN
cusj-6369	85	9	on	on	ADP
cusj-6369	85	10	go	go	VERB
cusj-6369	85	11	and	and	CCONJ
cusj-6369	85	12	hrp	hrp	PROPN
cusj-6369	85	13	were	be	AUX
cusj-6369	85	14	ranked	rank	VERB
cusj-6369	85	15	based	base	VERB
cusj-6369	85	16	on	on	ADP
cusj-6369	85	17	their	their	PRON
cusj-6369	85	18	selective	selective	ADJ
cusj-6369	85	19	inhibition	inhibition	NOUN
cusj-6369	85	20	of	of	ADP
cusj-6369	85	21	pag	pag	PROPN
cusj-6369	85	22	.	.	PROPN
cusj-6369	85	23	from	from	ADP
cusj-6369	85	24	this	this	DET
cusj-6369	85	25	list	list	NOUN
cusj-6369	85	26	of	of	ADP
cusj-6369	85	27	compounds	compound	NOUN
cusj-6369	85	28	,	,	PUNCT
cusj-6369	85	29	the	the	DET
cusj-6369	85	30	top	top	ADJ
cusj-6369	85	31	10	10	NUM
cusj-6369	85	32	were	be	AUX
cusj-6369	85	33	selected	select	VERB
cusj-6369	85	34	for	for	ADP
cusj-6369	85	35	kinetic	kinetic	ADJ
cusj-6369	85	36	analysis	analysis	NOUN
cusj-6369	85	37	.	.	PUNCT
cusj-6369	86	1	for	for	ADP
cusj-6369	86	2	2	2	NUM
cusj-6369	86	3	of	of	ADP
cusj-6369	86	4	these	these	DET
cusj-6369	86	5	10	10	NUM
cusj-6369	86	6	compounds	compound	NOUN
cusj-6369	86	7	,	,	PUNCT
cusj-6369	86	8	the	the	DET
cusj-6369	86	9	inhibition	inhibition	NOUN
cusj-6369	86	10	curve	curve	NOUN
cusj-6369	86	11	"	"	PUNCT
cusj-6369	86	12	t	t	NOUN
cusj-6369	86	13	michaelis	michaelis	ADJ
cusj-6369	86	14	-	-	PUNCT
cusj-6369	86	15	menten	menten	VERB
cusj-6369	86	16	kinetics	kinetic	NOUN
cusj-6369	86	17	.	.	PUNCT
cusj-6369	87	1	plots	plot	NOUN
cusj-6369	87	2	for	for	ADP
cusj-6369	87	3	these	these	DET
cusj-6369	87	4	2	2	NUM
cusj-6369	87	5	compounds	compound	NOUN
cusj-6369	87	6	,	,	PUNCT
cusj-6369	87	7	3d2	3d2	NUM
cusj-6369	87	8	and	and	CCONJ
cusj-6369	87	9	8o	8o	NUM
cusj-6369	87	10	,	,	PUNCT
cusj-6369	87	11	of	of	ADP
cusj-6369	87	12	reaction	reaction	NOUN
cusj-6369	87	13	velocity	velocity	NOUN
cusj-6369	87	14	versus	versus	ADP
cusj-6369	87	15	inhibitor	inhibitor	NOUN
cusj-6369	87	16	concentration	concentration	NOUN
cusj-6369	87	17	are	be	AUX
cusj-6369	87	18	shown	show	VERB
cusj-6369	87	19	below	below	ADP
cusj-6369	87	20	,	,	PUNCT
cusj-6369	87	21	and	and	CCONJ
cusj-6369	87	22	figure	figure	VERB
cusj-6369	87	23	5	5	NUM
cusj-6369	87	24	indicates	indicate	VERB
cusj-6369	87	25	the	the	DET
cusj-6369	87	26	ic50	ic50	PROPN
cusj-6369	87	27	values	value	NOUN
cusj-6369	87	28	3d2	3d2	NUM
cusj-6369	87	29	in	in	ADP
cusj-6369	87	30	four	four	NUM
cusj-6369	87	31	independent	independent	ADJ
cusj-6369	87	32	experiments	experiment	NOUN
cusj-6369	87	33	.	.	PUNCT
cusj-6369	88	1	#	#	SYM
cusj-6369	88	2	e	e	NOUN
cusj-6369	88	3	average	average	ADJ
cusj-6369	88	4	ic50	ic50	PROPN
cusj-6369	88	5	value	value	NOUN
cusj-6369	88	6	for	for	ADP
cusj-6369	88	7	3d2	3d2	NUM
cusj-6369	88	8	was	be	AUX
cusj-6369	88	9	4.272	4.272	NUM
cusj-6369	88	10	±	±	NUM
cusj-6369	88	11	0.572	0.572	NUM
cusj-6369	88	12	µm	µm	NOUN
cusj-6369	88	13	.	.	PUNCT
cusj-6369	89	1	as	as	SCONJ
cusj-6369	89	2	indicated	indicate	VERB
cusj-6369	89	3	by	by	ADP
cusj-6369	89	4	the	the	DET
cusj-6369	89	5	regression	regression	NOUN
cusj-6369	89	6	coe$cients	coe$cient	NOUN
cusj-6369	89	7	of	of	ADP
cusj-6369	89	8	each	each	DET
cusj-6369	89	9	experiment	experiment	NOUN
cusj-6369	89	10	,	,	PUNCT
cusj-6369	89	11	the	the	DET
cusj-6369	89	12	michaelis	michaelis	ADJ
cusj-6369	89	13	-	-	PUNCT
cusj-6369	89	14	menten	menten	ADJ
cusj-6369	89	15	model	model	NOUN
cusj-6369	89	16	of	of	ADP
cusj-6369	89	17	enzyme	enzyme	NOUN
cusj-6369	89	18	kinetics	kinetic	NOUN
cusj-6369	89	19	was	be	AUX
cusj-6369	89	20	applicable	applicable	ADJ
cusj-6369	89	21	to	to	ADP
cusj-6369	89	22	the	the	DET
cusj-6369	89	23	activity	activity	NOUN
cusj-6369	89	24	of	of	ADP
cusj-6369	89	25	3d2	3d2	NUM
cusj-6369	89	26	.	.	PUNCT
cusj-6369	90	1	based	base	VERB
cusj-6369	90	2	on	on	ADP
cusj-6369	90	3	its	its	PRON
cusj-6369	90	4	average	average	ADJ
cusj-6369	90	5	ic50	ic50	PROPN
cusj-6369	90	6	value	value	NOUN
cusj-6369	90	7	,	,	PUNCT
cusj-6369	90	8	inhibitor	inhibitor	NOUN
cusj-6369	90	9	3d2	3d2	NUM
cusj-6369	90	10	appears	appear	VERB
cusj-6369	90	11	worthy	worthy	ADJ
cusj-6369	90	12	of	of	ADP
cusj-6369	90	13	further	further	ADJ
cusj-6369	90	14	investigation	investigation	NOUN
cusj-6369	90	15	.	.	PUNCT
cusj-6369	91	1	because	because	SCONJ
cusj-6369	91	2	combinatorial	combinatorial	ADJ
cusj-6369	91	3	chemistry	chemistry	NOUN
cusj-6369	91	4	can	can	AUX
cusj-6369	91	5	be	be	AUX
cusj-6369	91	6	used	use	VERB
cusj-6369	91	7	to	to	PART
cusj-6369	91	8	optimize	optimize	VERB
cusj-6369	91	9	inhibitory	inhibitory	ADJ
cusj-6369	91	10	power	power	NOUN
cusj-6369	91	11	by	by	ADP
cusj-6369	91	12	up	up	ADP
cusj-6369	91	13	to	to	PART
cusj-6369	91	14	three	three	NUM
cusj-6369	91	15	orders	order	NOUN
cusj-6369	91	16	of	of	ADP
cusj-6369	91	17	magnitude	magnitude	NOUN
cusj-6369	91	18	,	,	PUNCT
cusj-6369	91	19	it	it	PRON
cusj-6369	91	20	appears	appear	VERB
cusj-6369	91	21	that	that	SCONJ
cusj-6369	91	22	optimization	optimization	NOUN
cusj-6369	91	23	of	of	ADP
cusj-6369	91	24	3d2	3d2	NUM
cusj-6369	91	25	particularly	particularly	ADV
cusj-6369	91	26	would	would	AUX
cusj-6369	91	27	produce	produce	VERB
cusj-6369	91	28	a	a	DET
cusj-6369	91	29	compound	compound	NOUN
cusj-6369	91	30	that	that	PRON
cusj-6369	91	31	would	would	AUX
cusj-6369	91	32	inhibit	inhibit	VERB
cusj-6369	91	33	pag	pag	PROPN
cusj-6369	91	34	in	in	ADP
cusj-6369	91	35	the	the	DET
cusj-6369	91	36	nanomolar	nanomolar	ADJ
cusj-6369	91	37	range	range	NOUN
cusj-6369	91	38	(	(	PUNCT
cusj-6369	91	39	jorgensen	jorgensen	PROPN
cusj-6369	91	40	,	,	PUNCT
cusj-6369	91	41	2009	2009	NUM
cusj-6369	91	42	)	)	PUNCT
cusj-6369	91	43	.	.	PUNCT
cusj-6369	92	1	at	at	ADP
cusj-6369	92	2	concentrations	concentration	NOUN
cusj-6369	92	3	lower	low	ADJ
cusj-6369	92	4	than	than	ADP
cusj-6369	92	5	10	10	NUM
cusj-6369	92	6	-	-	SYM
cusj-6369	92	7	4	4	NUM
cusj-6369	92	8	m	m	NOUN
cusj-6369	92	9	,	,	PUNCT
cusj-6369	92	10	8o	8o	PROPN
cusj-6369	92	11	also	also	ADV
cusj-6369	92	12	exhibits	exhibit	VERB
cusj-6369	92	13	similar	similar	ADJ
cusj-6369	92	14	dose	dose	NOUN
cusj-6369	92	15	-	-	PUNCT
cusj-6369	92	16	dependent	dependent	ADJ
cusj-6369	92	17	behavior	behavior	NOUN
cusj-6369	92	18	,	,	PUNCT
cusj-6369	92	19	but	but	CCONJ
cusj-6369	92	20	because	because	SCONJ
cusj-6369	92	21	of	of	ADP
cusj-6369	92	22	its	its	PRON
cusj-6369	92	23	unusual	unusual	ADJ
cusj-6369	92	24	behavior	behavior	NOUN
cusj-6369	92	25	for	for	ADP
cusj-6369	92	26	concentrations	concentration	NOUN
cusj-6369	92	27	greater	great	ADJ
cusj-6369	92	28	than	than	ADP
cusj-6369	92	29	this	this	PRON
cusj-6369	92	30	,	,	PUNCT
cusj-6369	92	31	where	where	SCONJ
cusj-6369	92	32	reaction	reaction	NOUN
cusj-6369	92	33	velocity	velocity	NOUN
cusj-6369	92	34	appears	appear	VERB
cusj-6369	92	35	to	to	PART
cusj-6369	92	36	increase	increase	VERB
cusj-6369	92	37	with	with	ADP
cusj-6369	92	38	greater	great	ADJ
cusj-6369	92	39	concentrations	concentration	NOUN
cusj-6369	92	40	of	of	ADP
cusj-6369	92	41	inhibitor	inhibitor	NOUN
cusj-6369	92	42	,	,	PUNCT
cusj-6369	92	43	it	it	PRON
cusj-6369	92	44	is	be	AUX
cusj-6369	92	45	necessary	necessary	ADJ
cusj-6369	92	46	to	to	PART
cusj-6369	92	47	subject	subject	VERB
cusj-6369	92	48	8o	8o	NUM
cusj-6369	92	49	to	to	ADP
cusj-6369	92	50	further	further	ADJ
cusj-6369	92	51	kinetic	kinetic	ADJ
cusj-6369	92	52	scrutiny	scrutiny	NOUN
cusj-6369	92	53	.	.	PUNCT
cusj-6369	93	1	for	for	ADP
cusj-6369	93	2	both	both	DET
cusj-6369	93	3	compounds	compound	NOUN
cusj-6369	93	4	,	,	PUNCT
cusj-6369	93	5	before	before	SCONJ
cusj-6369	93	6	they	they	PRON
cusj-6369	93	7	are	be	AUX
cusj-6369	93	8	to	to	PART
cusj-6369	93	9	be	be	AUX
cusj-6369	93	10	optimized	optimize	VERB
cusj-6369	93	11	,	,	PUNCT
cusj-6369	93	12	it	it	PRON
cusj-6369	93	13	is	be	AUX
cusj-6369	93	14	necessary	necessary	ADJ
cusj-6369	93	15	to	to	ADP
cusj-6369	93	16	con"rm	con"rm	NOUN
cusj-6369	93	17	their	their	PRON
cusj-6369	93	18	inhibitory	inhibitory	ADJ
cusj-6369	93	19	power	power	NOUN
cusj-6369	93	20	through	through	ADP
cusj-6369	93	21	alternative	alternative	ADJ
cusj-6369	93	22	assays	assay	NOUN
cusj-6369	93	23	and	and	CCONJ
cusj-6369	93	24	to	to	PART
cusj-6369	93	25	increase	increase	VERB
cusj-6369	93	26	the	the	DET
cusj-6369	93	27	number	number	NOUN
cusj-6369	93	28	of	of	ADP
cusj-6369	93	29	hits	hit	NOUN
cusj-6369	93	30	to	to	PART
cusj-6369	93	31	be	be	AUX
cusj-6369	93	32	optimized	optimize	VERB
cusj-6369	93	33	.	.	PUNCT
cusj-6369	94	1	#	#	SYM
cusj-6369	94	2	e	e	NOUN
cusj-6369	94	3	organization	organization	NOUN
cusj-6369	94	4	of	of	ADP
cusj-6369	94	5	the	the	DET
cusj-6369	94	6	primary	primary	ADJ
cusj-6369	94	7	screen	screen	NOUN
cusj-6369	94	8	experiments	experiment	NOUN
cusj-6369	94	9	into	into	ADP
cusj-6369	94	10	three	three	NUM
cusj-6369	94	11	categories	category	NOUN
cusj-6369	94	12	based	base	VERB
cusj-6369	94	13	on	on	ADP
cusj-6369	94	14	the	the	DET
cusj-6369	94	15	dynamic	dynamic	ADJ
cusj-6369	94	16	range	range	NOUN
cusj-6369	94	17	of	of	ADP
cusj-6369	94	18	control	control	NOUN
cusj-6369	94	19	%	%	NOUN
cusj-6369	94	20	uorescence	uorescence	NOUN
cusj-6369	94	21	enabled	enable	VERB
cusj-6369	94	22	comparison	comparison	NOUN
cusj-6369	94	23	between	between	ADP
cusj-6369	94	24	plates	plate	NOUN
cusj-6369	94	25	and	and	CCONJ
cusj-6369	94	26	appropriate	appropriate	ADJ
cusj-6369	94	27	selection	selection	NOUN
cusj-6369	94	28	of	of	ADP
cusj-6369	94	29	hits	hit	NOUN
cusj-6369	94	30	.	.	PUNCT
cusj-6369	95	1	for	for	ADP
cusj-6369	95	2	plates	plate	NOUN
cusj-6369	95	3	with	with	ADP
cusj-6369	95	4	a	a	DET
cusj-6369	95	5	good	good	ADJ
cusj-6369	95	6	dynamic	dynamic	ADJ
cusj-6369	95	7	range	range	NOUN
cusj-6369	95	8	,	,	PUNCT
cusj-6369	95	9	there	there	PRON
cusj-6369	95	10	were	be	VERB
cusj-6369	95	11	few	few	ADJ
cusj-6369	95	12	or	or	CCONJ
cusj-6369	95	13	no	no	PRON
cusj-6369	95	14	compounds	compound	NOUN
cusj-6369	95	15	with	with	ADP
cusj-6369	95	16	greater	great	ADJ
cusj-6369	95	17	than	than	ADP
cusj-6369	95	18	90	90	NUM
cusj-6369	95	19	%	%	NOUN
cusj-6369	95	20	inhibition	inhibition	NOUN
cusj-6369	95	21	.	.	PUNCT
cusj-6369	96	1	however	however	ADV
cusj-6369	96	2	,	,	PUNCT
cusj-6369	96	3	for	for	ADP
cusj-6369	96	4	plates	plate	NOUN
cusj-6369	96	5	with	with	ADP
cusj-6369	96	6	an	an	DET
cusj-6369	96	7	extreme	extreme	ADJ
cusj-6369	96	8	(	(	PUNCT
cusj-6369	96	9	low	low	ADJ
cusj-6369	96	10	or	or	CCONJ
cusj-6369	96	11	high	high	ADJ
cusj-6369	96	12	)	)	PUNCT
cusj-6369	96	13	or	or	CCONJ
cusj-6369	96	14	non	non	ADJ
cusj-6369	96	15	-	-	ADJ
cusj-6369	96	16	existent	existent	ADJ
cusj-6369	96	17	dynamic	dynamic	ADJ
cusj-6369	96	18	range	range	NOUN
cusj-6369	96	19	,	,	PUNCT
cusj-6369	96	20	there	there	PRON
cusj-6369	96	21	were	be	VERB
cusj-6369	96	22	many	many	ADJ
cusj-6369	96	23	compounds	compound	NOUN
cusj-6369	96	24	with	with	ADP
cusj-6369	96	25	greater	great	ADJ
cusj-6369	96	26	than	than	ADP
cusj-6369	96	27	90	90	NUM
cusj-6369	96	28	%	%	NOUN
cusj-6369	96	29	inhibition	inhibition	NOUN
cusj-6369	96	30	and	and	CCONJ
cusj-6369	96	31	even	even	ADV
cusj-6369	96	32	some	some	PRON
cusj-6369	96	33	well	well	NOUN
cusj-6369	96	34	above	above	ADP
cusj-6369	96	35	100	100	NUM
cusj-6369	96	36	%	%	NOUN
cusj-6369	96	37	.	.	PUNCT
cusj-6369	97	1	#	#	NOUN
cusj-6369	97	2	is	be	AUX
cusj-6369	97	3	result	result	NOUN
cusj-6369	97	4	most	most	ADV
cusj-6369	97	5	likely	likely	ADV
cusj-6369	97	6	does	do	AUX
cusj-6369	97	7	not	not	PART
cusj-6369	97	8	indicate	indicate	VERB
cusj-6369	97	9	a	a	DET
cusj-6369	97	10	greater	great	ADJ
cusj-6369	97	11	number	number	NOUN
cusj-6369	97	12	of	of	ADP
cusj-6369	97	13	hits	hit	NOUN
cusj-6369	97	14	for	for	ADP
cusj-6369	97	15	these	these	DET
cusj-6369	97	16	two	two	NUM
cusj-6369	97	17	categories	category	NOUN
cusj-6369	97	18	of	of	ADP
cusj-6369	97	19	plates	plate	NOUN
cusj-6369	97	20	;	;	PUNCT
cusj-6369	97	21	indeed	indeed	ADV
cusj-6369	97	22	,	,	PUNCT
cusj-6369	97	23	the	the	DET
cusj-6369	97	24	>	>	SYM
cusj-6369	97	25	100	100	NUM
cusj-6369	97	26	%	%	NOUN
cusj-6369	97	27	inhibitors	inhibitor	NOUN
cusj-6369	97	28	suggests	suggest	VERB
cusj-6369	97	29	that	that	SCONJ
cusj-6369	97	30	the	the	DET
cusj-6369	97	31	large	large	ADJ
cusj-6369	97	32	number	number	NOUN
cusj-6369	97	33	of	of	ADP
cusj-6369	97	34	apparent	apparent	ADJ
cusj-6369	97	35	hits	hit	NOUN
cusj-6369	97	36	with	with	ADP
cusj-6369	97	37	percent	percent	NOUN
cusj-6369	97	38	inhibition	inhibition	NOUN
cusj-6369	97	39	>	>	NOUN
cusj-6369	97	40	90	90	NUM
cusj-6369	97	41	%	%	NOUN
cusj-6369	97	42	is	be	AUX
cusj-6369	97	43	an	an	DET
cusj-6369	97	44	artifact	artifact	NOUN
cusj-6369	97	45	of	of	ADP
cusj-6369	97	46	an	an	DET
cusj-6369	97	47	abnormal	abnormal	ADJ
cusj-6369	97	48	dynamic	dynamic	ADJ
cusj-6369	97	49	range	range	NOUN
cusj-6369	97	50	.	.	PUNCT
cusj-6369	98	1	#	#	ADV
cusj-6369	98	2	erefore	erefore	ADV
cusj-6369	98	3	,	,	PUNCT
cusj-6369	98	4	the	the	DET
cusj-6369	98	5	division	division	NOUN
cusj-6369	98	6	of	of	ADP
cusj-6369	98	7	the	the	DET
cusj-6369	98	8	plates	plate	NOUN
cusj-6369	98	9	into	into	ADP
cusj-6369	98	10	the	the	DET
cusj-6369	98	11	three	three	NUM
cusj-6369	98	12	categories	category	NOUN
cusj-6369	98	13	and	and	CCONJ
cusj-6369	98	14	the	the	DET
cusj-6369	98	15	selection	selection	NOUN
cusj-6369	98	16	of	of	ADP
cusj-6369	98	17	outliers	outlier	NOUN
cusj-6369	98	18	from	from	ADP
cusj-6369	98	19	the	the	DET
cusj-6369	98	20	two	two	NUM
cusj-6369	98	21	categories	category	NOUN
cusj-6369	98	22	of	of	ADP
cusj-6369	98	23	plates	plate	NOUN
cusj-6369	98	24	with	with	ADP
cusj-6369	98	25	abnormal	abnormal	ADJ
cusj-6369	98	26	values	value	NOUN
cusj-6369	98	27	for	for	ADP
cusj-6369	98	28	dynamic	dynamic	ADJ
cusj-6369	98	29	range	range	NOUN
cusj-6369	98	30	were	be	AUX
cusj-6369	98	31	used	use	VERB
cusj-6369	98	32	to	to	PART
cusj-6369	98	33	correct	correct	VERB
cusj-6369	98	34	this	this	DET
cusj-6369	98	35	artifact	artifact	NOUN
cusj-6369	98	36	so	so	SCONJ
cusj-6369	98	37	that	that	SCONJ
cusj-6369	98	38	only	only	ADJ
cusj-6369	98	39	outliers	outlier	NOUN
cusj-6369	98	40	were	be	AUX
cusj-6369	98	41	selected	select	VERB
cusj-6369	98	42	from	from	ADP
cusj-6369	98	43	every	every	DET
cusj-6369	98	44	plate	plate	NOUN
cusj-6369	98	45	.	.	PUNCT
cusj-6369	99	1	#	#	SYM
cusj-6369	99	2	e	e	PROPN
cusj-6369	99	3	secondary	secondary	ADJ
cusj-6369	99	4	screen	screen	NOUN
cusj-6369	99	5	was	be	AUX
cusj-6369	99	6	designed	design	VERB
cusj-6369	99	7	to	to	PART
cusj-6369	99	8	eliminate	eliminate	VERB
cusj-6369	99	9	nonspeci"c	nonspeci"c	ADJ
cusj-6369	99	10	inhibitors	inhibitor	NOUN
cusj-6369	99	11	and	and	CCONJ
cusj-6369	99	12	false	false	ADJ
cusj-6369	99	13	positives	positive	NOUN
cusj-6369	99	14	from	from	ADP
cusj-6369	99	15	the	the	DET
cusj-6369	99	16	screen	screen	NOUN
cusj-6369	99	17	.	.	PUNCT
cusj-6369	100	1	in	in	ADP
cusj-6369	100	2	testing	testing	NOUN
cusj-6369	100	3	for	for	ADP
cusj-6369	100	4	inhibition	inhibition	NOUN
cusj-6369	100	5	of	of	ADP
cusj-6369	100	6	glutamate	glutamate	ADJ
cusj-6369	100	7	oxidase	oxidase	NOUN
cusj-6369	100	8	and	and	CCONJ
cusj-6369	100	9	horseradish	horseradish	ADJ
cusj-6369	100	10	peroxidase	peroxidase	NOUN
cusj-6369	100	11	,	,	PUNCT
cusj-6369	100	12	the	the	DET
cusj-6369	100	13	secondary	secondary	ADJ
cusj-6369	100	14	screen	screen	NOUN
cusj-6369	100	15	was	be	AUX
cusj-6369	100	16	able	able	ADJ
cusj-6369	100	17	to	to	PART
cusj-6369	100	18	exclude	exclude	VERB
cusj-6369	100	19	compounds	compound	NOUN
cusj-6369	100	20	that	that	PRON
cusj-6369	100	21	were	be	AUX
cusj-6369	100	22	potential	potential	ADJ
cusj-6369	100	23	inhibitors	inhibitor	NOUN
cusj-6369	100	24	of	of	ADP
cusj-6369	100	25	these	these	DET
cusj-6369	100	26	kit	kit	NOUN
cusj-6369	100	27	enzymes	enzyme	NOUN
cusj-6369	100	28	.	.	PUNCT
cusj-6369	101	1	in	in	ADP
cusj-6369	101	2	addition	addition	NOUN
cusj-6369	101	3	to	to	ADP
cusj-6369	101	4	this	this	DET
cusj-6369	101	5	secondary	secondary	ADJ
cusj-6369	101	6	assay	assay	NOUN
cusj-6369	101	7	,	,	PUNCT
cusj-6369	101	8	it	it	PRON
cusj-6369	101	9	is	be	AUX
cusj-6369	101	10	necessary	necessary	ADJ
cusj-6369	101	11	to	to	ADP
cusj-6369	101	12	con"rm	con"rm	NOUN
cusj-6369	101	13	the	the	DET
cusj-6369	101	14	inhibitory	inhibitory	ADJ
cusj-6369	101	15	power	power	NOUN
cusj-6369	101	16	of	of	ADP
cusj-6369	101	17	3d2	3d2	NUM
cusj-6369	101	18	using	use	VERB
cusj-6369	101	19	another	another	DET
cusj-6369	101	20	assay	assay	NOUN
cusj-6369	101	21	without	without	ADP
cusj-6369	101	22	the	the	DET
cusj-6369	101	23	use	use	NOUN
cusj-6369	101	24	of	of	ADP
cusj-6369	101	25	amplex	amplex	NOUN
cusj-6369	101	26	red	red	ADJ
cusj-6369	101	27	;	;	PUNCT
cusj-6369	101	28	one	one	NUM
cusj-6369	101	29	such	such	ADJ
cusj-6369	101	30	assay	assay	NOUN
cusj-6369	101	31	involves	involve	VERB
cusj-6369	101	32	the	the	DET
cusj-6369	101	33	direct	direct	ADJ
cusj-6369	101	34	determination	determination	NOUN
cusj-6369	101	35	of	of	ADP
cusj-6369	101	36	glutamate	glutamate	NOUN
cusj-6369	101	37	as	as	ADP
cusj-6369	101	38	a	a	DET
cusj-6369	101	39	product	product	NOUN
cusj-6369	101	40	of	of	ADP
cusj-6369	101	41	pag	pag	PROPN
cusj-6369	101	42	catalysis	catalysis	NOUN
cusj-6369	101	43	.	.	PUNCT
cusj-6369	102	1	from	from	ADP
cusj-6369	102	2	the	the	DET
cusj-6369	102	3	ic50	ic50	PROPN
cusj-6369	102	4	curve	curve	NOUN
cusj-6369	102	5	of	of	ADP
cusj-6369	102	6	8o	8o	NUM
cusj-6369	102	7	,	,	PUNCT
cusj-6369	102	8	it	it	PRON
cusj-6369	102	9	appears	appear	VERB
cusj-6369	102	10	that	that	SCONJ
cusj-6369	102	11	for	for	SCONJ
cusj-6369	102	12	concentrations	concentration	NOUN
cusj-6369	102	13	of	of	ADP
cusj-6369	102	14	inhibitor	inhibitor	NOUN
cusj-6369	102	15	greater	great	ADJ
cusj-6369	102	16	than	than	ADP
cusj-6369	102	17	10	10	NUM
cusj-6369	102	18	-	-	SYM
cusj-6369	102	19	4	4	NUM
cusj-6369	102	20	m	m	NOUN
cusj-6369	102	21	,	,	PUNCT
cusj-6369	102	22	the	the	DET
cusj-6369	102	23	reaction	reaction	NOUN
cusj-6369	102	24	rate	rate	NOUN
cusj-6369	102	25	is	be	AUX
cusj-6369	102	26	actually	actually	ADV
cusj-6369	102	27	higher	high	ADJ
cusj-6369	102	28	than	than	SCONJ
cusj-6369	102	29	it	it	PRON
cusj-6369	102	30	is	be	AUX
cusj-6369	102	31	for	for	ADP
cusj-6369	102	32	lower	low	ADJ
cusj-6369	102	33	concentrations	concentration	NOUN
cusj-6369	102	34	;	;	PUNCT
cusj-6369	102	35	otherwise	otherwise	ADV
cusj-6369	102	36	,	,	PUNCT
cusj-6369	102	37	for	for	ADP
cusj-6369	102	38	concentrations	concentration	NOUN
cusj-6369	102	39	below	below	ADP
cusj-6369	102	40	10	10	NUM
cusj-6369	102	41	-	-	SYM
cusj-6369	102	42	4	4	NUM
cusj-6369	102	43	m	m	NOUN
cusj-6369	102	44	,	,	PUNCT
cusj-6369	102	45	8o	8o	PROPN
cusj-6369	102	46	appears	appear	VERB
cusj-6369	102	47	to	to	PART
cusj-6369	102	48	adhere	adhere	VERB
cusj-6369	102	49	to	to	ADP
cusj-6369	102	50	the	the	DET
cusj-6369	102	51	dose	dose	NOUN
cusj-6369	102	52	-	-	PUNCT
cusj-6369	102	53	dependent	dependent	ADJ
cusj-6369	102	54	pattern	pattern	NOUN
cusj-6369	102	55	normally	normally	ADV
cusj-6369	102	56	seen	see	VERB
cusj-6369	102	57	with	with	ADP
cusj-6369	102	58	good	good	ADJ
cusj-6369	102	59	inhibitors	inhibitor	NOUN
cusj-6369	102	60	.	.	PUNCT
cusj-6369	103	1	a	a	DET
cusj-6369	103	2	likely	likely	ADJ
cusj-6369	103	3	explanation	explanation	NOUN
cusj-6369	103	4	for	for	ADP
cusj-6369	103	5	this	this	DET
cusj-6369	103	6	unusual	unusual	ADJ
cusj-6369	103	7	pattern	pattern	NOUN
cusj-6369	103	8	is	be	AUX
cusj-6369	103	9	that	that	SCONJ
cusj-6369	103	10	8o	8o	PROPN
cusj-6369	103	11	is	be	AUX
cusj-6369	103	12	itself	itself	PRON
cusj-6369	103	13	%	%	ADV
cusj-6369	103	14	uorescent	uorescent	ADJ
cusj-6369	103	15	and	and	CCONJ
cusj-6369	103	16	enhances	enhance	VERB
cusj-6369	103	17	the	the	DET
cusj-6369	103	18	%	%	NOUN
cusj-6369	103	19	uorescence	uorescence	NOUN
cusj-6369	103	20	signal	signal	NOUN
cusj-6369	103	21	at	at	ADP
cusj-6369	103	22	high	high	ADJ
cusj-6369	103	23	concentrations	concentration	NOUN
cusj-6369	103	24	.	.	PUNCT
cusj-6369	104	1	one	one	NUM
cusj-6369	104	2	caveat	caveat	NOUN
cusj-6369	104	3	to	to	ADP
cusj-6369	104	4	michalis	michali	VERB
cusj-6369	104	5	-	-	PUNCT
cusj-6369	104	6	menten	menten	VERB
cusj-6369	104	7	kinetics	kinetic	NOUN
cusj-6369	104	8	determinations	determination	NOUN
cusj-6369	104	9	is	be	AUX
cusj-6369	104	10	that	that	SCONJ
cusj-6369	104	11	the	the	DET
cusj-6369	104	12	value	value	NOUN
cusj-6369	104	13	of	of	ADP
cusj-6369	104	14	the	the	DET
cusj-6369	104	15	ic50	ic50	PROPN
cusj-6369	104	16	measurement	measurement	NOUN
cusj-6369	104	17	is	be	AUX
cusj-6369	104	18	in	in	ADP
cusj-6369	104	19	itself	itself	PRON
cusj-6369	104	20	limited	limited	ADJ
cusj-6369	104	21	;	;	PUNCT
cusj-6369	104	22	ic50	ic50	PROPN
cusj-6369	104	23	depends	depend	VERB
cusj-6369	104	24	on	on	ADP
cusj-6369	104	25	the	the	DET
cusj-6369	104	26	concentration	concentration	NOUN
cusj-6369	104	27	of	of	ADP
cusj-6369	104	28	substrate	substrate	NOUN
cusj-6369	104	29	,	,	PUNCT
cusj-6369	104	30	enzyme	enzyme	NOUN
cusj-6369	104	31	,	,	PUNCT
cusj-6369	104	32	and	and	CCONJ
cusj-6369	104	33	inhibitor	inhibitor	NOUN
cusj-6369	104	34	,	,	PUNCT
cusj-6369	104	35	as	as	ADV
cusj-6369	104	36	well	well	ADV
cusj-6369	104	37	as	as	ADP
cusj-6369	104	38	other	other	ADJ
cusj-6369	104	39	experimental	experimental	ADJ
cusj-6369	104	40	conditions	condition	NOUN
cusj-6369	104	41	.	.	PUNCT
cusj-6369	105	1	ki	ki	INTJ
cusj-6369	105	2	,	,	PUNCT
cusj-6369	105	3	the	the	DET
cusj-6369	105	4	dissociation	dissociation	NOUN
cusj-6369	105	5	constant	constant	ADJ
cusj-6369	105	6	of	of	ADP
cusj-6369	105	7	the	the	DET
cusj-6369	105	8	inhibitor	inhibitor	NOUN
cusj-6369	105	9	to	to	ADP
cusj-6369	105	10	the	the	DET
cusj-6369	105	11	enzyme	enzyme	NOUN
cusj-6369	105	12	,	,	PUNCT
cusj-6369	105	13	is	be	AUX
cusj-6369	105	14	a	a	DET
cusj-6369	105	15	more	more	ADV
cusj-6369	105	16	valuable	valuable	ADJ
cusj-6369	105	17	measurement	measurement	NOUN
cusj-6369	105	18	because	because	SCONJ
cusj-6369	105	19	it	it	PRON
cusj-6369	105	20	is	be	AUX
cusj-6369	105	21	an	an	DET
cusj-6369	105	22	intrinsic	intrinsic	ADJ
cusj-6369	105	23	thermodynamic	thermodynamic	ADJ
cusj-6369	105	24	quantity	quantity	NOUN
cusj-6369	105	25	independent	independent	ADJ
cusj-6369	105	26	of	of	ADP
cusj-6369	105	27	substrate	substrate	NOUN
cusj-6369	105	28	concentration	concentration	NOUN
cusj-6369	105	29	,	,	PUNCT
cusj-6369	105	30	but	but	CCONJ
cusj-6369	105	31	dependent	dependent	ADJ
cusj-6369	105	32	on	on	ADP
cusj-6369	105	33	enzyme	enzyme	NOUN
cusj-6369	105	34	and	and	CCONJ
cusj-6369	105	35	inhibitor	inhibitor	NOUN
cusj-6369	105	36	concentrations	concentration	NOUN
cusj-6369	105	37	.	.	PUNCT
cusj-6369	106	1	for	for	ADP
cusj-6369	106	2	this	this	DET
cusj-6369	106	3	reason	reason	NOUN
cusj-6369	106	4	,	,	PUNCT
cusj-6369	106	5	ki	ki	PROPN
cusj-6369	106	6	measurements	measurement	NOUN
cusj-6369	106	7	are	be	AUX
cusj-6369	106	8	more	more	ADV
cusj-6369	106	9	replicable	replicable	ADJ
cusj-6369	106	10	across	across	ADP
cusj-6369	106	11	di&erent	di&erent	ADJ
cusj-6369	106	12	experimental	experimental	ADJ
cusj-6369	106	13	methods	method	NOUN
cusj-6369	106	14	(	(	PUNCT
cusj-6369	106	15	cer	cer	NOUN
cusj-6369	106	16	,	,	PUNCT
cusj-6369	106	17	2009	2009	NUM
cusj-6369	106	18	)	)	PUNCT
cusj-6369	106	19	.	.	PUNCT
cusj-6369	107	1	#	#	SYM
cusj-6369	107	2	ere	ere	NOUN
cusj-6369	107	3	are	be	AUX
cusj-6369	107	4	ways	way	NOUN
cusj-6369	107	5	of	of	ADP
cusj-6369	107	6	measuring	measure	VERB
cusj-6369	107	7	ki	ki	PROPN
cusj-6369	107	8	based	base	VERB
cusj-6369	107	9	on	on	ADP
cusj-6369	107	10	ic50	ic50	PROPN
cusj-6369	107	11	values	value	NOUN
cusj-6369	107	12	,	,	PUNCT
cusj-6369	107	13	one	one	NUM
cusj-6369	107	14	columbia	columbia	PROPN
cusj-6369	107	15	undergraduate	undergraduate	PROPN
cusj-6369	107	16	science	science	PROPN
cusj-6369	107	17	journal	journal	PROPN
cusj-6369	107	18	open	open	ADJ
cusj-6369	107	19	-	-	PUNCT
cusj-6369	107	20	access	access	NOUN
cusj-6369	107	21	publication	publication	NOUN
cusj-6369	107	22	|	|	NOUN
cusj-6369	107	23	http://cusj.columbia.edu	http://cusj.columbia.edu	PROPN
cusj-6369	107	24	7	7	NUM
cusj-6369	107	25	cusjvolume	cusjvolume	ADJ
cusj-6369	107	26	6spring	6spring	NUM
cusj-6369	107	27	2012	2012	NUM
cusj-6369	107	28	columbia	columbia	PROPN
cusj-6369	107	29	undergraduate	undergraduate	NOUN
cusj-6369	107	30	sci	sci	PROPN
cusj-6369	107	31	j	j	PROPN
cusj-6369	107	32	http://cusj.columbia.edu	http://cusj.columbia.edu	PROPN
cusj-6369	108	1	p	p	X
cusj-6369	108	2	s	s	X
cusj-6369	108	3	y	y	PROPN
cusj-6369	108	4	c	c	PROPN
cusj-6369	108	5	h	h	PROPN
cusj-6369	108	6	ia	ia	PROPN
cusj-6369	108	7	tr	tr	PROPN
cusj-6369	108	8	y	y	PROPN
cusj-6369	108	9	figure	figure	NOUN
cusj-6369	108	10	5	5	NUM
cusj-6369	108	11	ic	ic	NUM
cusj-6369	108	12	�	�	PROPN
cusj-6369	108	13	�	�	PROPN
cusj-6369	108	14	�	�	PROPN
cusj-6369	108	15	ydoxhv	ydoxhv	PROPN
cusj-6369	108	16	�	�	PROPN
cusj-6369	108	17	ghwhuplqhg	ghwhuplqhg	PROPN
cusj-6369	108	18	�	�	PROPN
cusj-6369	108	19	iru	iru	PROPN
cusj-6369	108	20	�	�	PROPN
cusj-6369	108	21	�	�	PROPN
cusj-6369	108	22	'	'	PART
cusj-6369	108	23	�	�	PROPN
cusj-6369	108	24	�	�	PROPN
cusj-6369	108	25	zlwk	zlwk	PROPN
cusj-6369	108	26	�	�	PROPN
cusj-6369	108	27	fruuhvsrqglqj	fruuhvsrqglqj	NOUN
cusj-6369	108	28	�	�	SYM
cusj-6369	108	29	5	5	NUM
cusj-6369	108	30	�	�	PROPN
cusj-6369	108	31	values	value	NOUN
cusj-6369	108	32	.	.	PUNCT
cusj-6369	109	1	�	�	PROPN
cusj-6369	109	2	2	2	NUM
cusj-6369	109	3	�	�	PROPN
cusj-6369	109	4	zdv	zdv	PROPN
cusj-6369	109	5	�	�	PROPN
cusj-6369	109	6	qrw	qrw	PROPN
cusj-6369	109	7	�	�	PROPN
cusj-6369	109	8	whvwhg	whvwhg	PROPN
cusj-6369	109	9	�	�	PROPN
cusj-6369	109	10	rq	rq	PROPN
cusj-6369	109	11	�	�	PROPN
cusj-6369	109	12	�	�	PROPN
cusj-6369	109	13	�	�	PROPN
cusj-6369	109	14	�	�	PROPN
cusj-6369	109	15	�	�	PROPN
cusj-6369	109	16	�	�	PROPN
cusj-6369	109	17	�	�	PROPN
cusj-6369	109	18	�	�	PROPN
cusj-6369	109	19	�	�	PROPN
cusj-6369	109	20	�	�	PROPN
cusj-6369	109	21	�	�	PROPN
cusj-6369	109	22	of	of	ADP
cusj-6369	109	23	which	which	PRON
cusj-6369	109	24	is	be	AUX
cusj-6369	109	25	the	the	DET
cusj-6369	109	26	cheng	cheng	PROPN
cusj-6369	109	27	-	-	PUNCT
cusj-6369	109	28	pruso	pruso	PROPN
cusj-6369	109	29	&	&	CCONJ
cusj-6369	109	30	equation	equation	NOUN
cusj-6369	109	31	:	:	PUNCT
cusj-6369	109	32	ki=	ki=	PROPN
cusj-6369	109	33	ic50/(1+[s]/km	ic50/(1+[s]/km	PROPN
cusj-6369	109	34	)	)	PUNCT
cusj-6369	110	1	however	however	ADV
cusj-6369	110	2	,	,	PUNCT
cusj-6369	110	3	this	this	DET
cusj-6369	110	4	equation	equation	NOUN
cusj-6369	110	5	is	be	AUX
cusj-6369	110	6	used	use	VERB
cusj-6369	110	7	to	to	PART
cusj-6369	110	8	calculate	calculate	VERB
cusj-6369	110	9	ki	ki	PROPN
cusj-6369	110	10	for	for	ADP
cusj-6369	110	11	inhibitors	inhibitor	NOUN
cusj-6369	110	12	known	know	VERB
cusj-6369	110	13	to	to	PART
cusj-6369	110	14	be	be	AUX
cusj-6369	110	15	competitive	competitive	ADJ
cusj-6369	110	16	(	(	PUNCT
cusj-6369	110	17	copeland	copeland	PROPN
cusj-6369	110	18	,	,	PUNCT
cusj-6369	110	19	2000	2000	NUM
cusj-6369	110	20	)	)	PUNCT
cusj-6369	110	21	.	.	PUNCT
cusj-6369	111	1	another	another	DET
cusj-6369	111	2	method	method	NOUN
cusj-6369	111	3	that	that	PRON
cusj-6369	111	4	can	can	AUX
cusj-6369	111	5	be	be	AUX
cusj-6369	111	6	used	use	VERB
cusj-6369	111	7	to	to	PART
cusj-6369	111	8	determine	determine	VERB
cusj-6369	111	9	ki	ki	PROPN
cusj-6369	111	10	is	be	AUX
cusj-6369	111	11	through	through	ADP
cusj-6369	111	12	the	the	DET
cusj-6369	111	13	use	use	NOUN
cusj-6369	111	14	of	of	ADP
cusj-6369	111	15	the	the	DET
cusj-6369	111	16	lineweaver	lineweaver	ADJ
cusj-6369	111	17	-	-	PUNCT
cusj-6369	111	18	burk	burk	NOUN
cusj-6369	111	19	plot	plot	NOUN
cusj-6369	111	20	,	,	PUNCT
cusj-6369	111	21	which	which	DET
cusj-6369	111	22	graphpad	graphpad	NOUN
cusj-6369	111	23	prism	prism	NOUN
cusj-6369	111	24	4	4	NUM
cusj-6369	111	25	can	can	AUX
cusj-6369	111	26	generate	generate	VERB
cusj-6369	111	27	.	.	PUNCT
cusj-6369	112	1	#	#	NOUN
cusj-6369	112	2	ese	ese	NOUN
cusj-6369	112	3	plots	plot	NOUN
cusj-6369	112	4	are	be	AUX
cusj-6369	112	5	obtained	obtain	VERB
cusj-6369	112	6	by	by	ADP
cusj-6369	112	7	varying	vary	VERB
cusj-6369	112	8	both	both	CCONJ
cusj-6369	112	9	inhibitor	inhibitor	NOUN
cusj-6369	112	10	and	and	CCONJ
cusj-6369	112	11	enzyme	enzyme	NOUN
cusj-6369	112	12	concentration	concentration	NOUN
cusj-6369	112	13	,	,	PUNCT
cusj-6369	112	14	and	and	CCONJ
cusj-6369	112	15	can	can	AUX
cusj-6369	112	16	both	both	PRON
cusj-6369	112	17	elucidate	elucidate	VERB
cusj-6369	112	18	the	the	DET
cusj-6369	112	19	nature	nature	NOUN
cusj-6369	112	20	of	of	ADP
cusj-6369	112	21	the	the	DET
cusj-6369	112	22	inhibitor	inhibitor	NOUN
cusj-6369	112	23	(	(	PUNCT
cusj-6369	112	24	competitive	competitive	ADJ
cusj-6369	112	25	,	,	PUNCT
cusj-6369	112	26	noncompetitive	noncompetitive	ADJ
cusj-6369	112	27	,	,	PUNCT
cusj-6369	112	28	or	or	CCONJ
cusj-6369	112	29	uncompetitive	uncompetitive	ADJ
cusj-6369	112	30	)	)	PUNCT
cusj-6369	112	31	and	and	CCONJ
cusj-6369	112	32	be	be	AUX
cusj-6369	112	33	used	use	VERB
cusj-6369	112	34	to	to	PART
cusj-6369	112	35	calculate	calculate	VERB
cusj-6369	112	36	ki	ki	PROPN
cusj-6369	112	37	(	(	PUNCT
cusj-6369	112	38	copeland	copeland	PROPN
cusj-6369	112	39	,	,	PUNCT
cusj-6369	112	40	2000	2000	NUM
cusj-6369	112	41	)	)	PUNCT
cusj-6369	112	42	.	.	PUNCT
cusj-6369	113	1	knowing	know	VERB
cusj-6369	113	2	the	the	DET
cusj-6369	113	3	nature	nature	NOUN
cusj-6369	113	4	of	of	ADP
cusj-6369	113	5	the	the	DET
cusj-6369	113	6	inhibitor	inhibitor	NOUN
cusj-6369	113	7	will	will	AUX
cusj-6369	113	8	allow	allow	VERB
cusj-6369	113	9	prioritization	prioritization	NOUN
cusj-6369	113	10	of	of	ADP
cusj-6369	113	11	the	the	DET
cusj-6369	113	12	leads	lead	NOUN
cusj-6369	113	13	for	for	ADP
cusj-6369	113	14	optimization	optimization	NOUN
cusj-6369	113	15	.	.	PUNCT
cusj-6369	114	1	noncompetitive	noncompetitive	ADJ
cusj-6369	114	2	inhibitors	inhibitor	NOUN
cusj-6369	114	3	will	will	AUX
cusj-6369	114	4	be	be	AUX
cusj-6369	114	5	favored	favor	VERB
cusj-6369	114	6	for	for	ADP
cusj-6369	114	7	optimization	optimization	NOUN
cusj-6369	114	8	over	over	ADP
cusj-6369	114	9	competitive	competitive	ADJ
cusj-6369	114	10	inhibitors	inhibitor	NOUN
cusj-6369	114	11	.	.	PUNCT
cusj-6369	115	1	competitive	competitive	ADJ
cusj-6369	115	2	inhibitors	inhibitor	NOUN
cusj-6369	115	3	,	,	PUNCT
cusj-6369	115	4	binding	bind	VERB
cusj-6369	115	5	to	to	ADP
cusj-6369	115	6	the	the	DET
cusj-6369	115	7	enzyme	enzyme	NOUN
cusj-6369	115	8	’s	’s	PART
cusj-6369	115	9	active	active	ADJ
cusj-6369	115	10	site	site	NOUN
cusj-6369	115	11	,	,	PUNCT
cusj-6369	115	12	are	be	AUX
cusj-6369	115	13	less	less	ADV
cusj-6369	115	14	likely	likely	ADJ
cusj-6369	115	15	to	to	PART
cusj-6369	115	16	be	be	AUX
cusj-6369	115	17	speci"c	speci"c	PROPN
cusj-6369	115	18	to	to	PART
cusj-6369	115	19	pag	pag	PROPN
cusj-6369	115	20	,	,	PUNCT
cusj-6369	115	21	as	as	SCONJ
cusj-6369	115	22	they	they	PRON
cusj-6369	115	23	are	be	AUX
cusj-6369	115	24	also	also	ADV
cusj-6369	115	25	likely	likely	ADJ
cusj-6369	115	26	to	to	PART
cusj-6369	115	27	bind	bind	VERB
cusj-6369	115	28	to	to	ADP
cusj-6369	115	29	the	the	DET
cusj-6369	115	30	active	active	ADJ
cusj-6369	115	31	sites	site	NOUN
cusj-6369	115	32	of	of	ADP
cusj-6369	115	33	other	other	ADJ
cusj-6369	115	34	enzymes	enzyme	NOUN
cusj-6369	115	35	in	in	ADP
cusj-6369	115	36	the	the	DET
cusj-6369	115	37	glutamate	glutamate	NOUN
cusj-6369	115	38	cycle	cycle	NOUN
cusj-6369	115	39	.	.	PUNCT
cusj-6369	116	1	#	#	ADV
cusj-6369	116	2	erefore	erefore	ADV
cusj-6369	116	3	,	,	PUNCT
cusj-6369	116	4	since	since	SCONJ
cusj-6369	116	5	pagspeci"city	pagspeci"city	NOUN
cusj-6369	116	6	is	be	AUX
cusj-6369	116	7	one	one	NUM
cusj-6369	116	8	of	of	ADP
cusj-6369	116	9	the	the	DET
cusj-6369	116	10	selection	selection	NOUN
cusj-6369	116	11	criteria	criterion	NOUN
cusj-6369	116	12	,	,	PUNCT
cusj-6369	116	13	and	and	CCONJ
cusj-6369	116	14	competitive	competitive	ADJ
cusj-6369	116	15	inhibitors	inhibitor	NOUN
cusj-6369	116	16	are	be	AUX
cusj-6369	116	17	unlikely	unlikely	ADJ
cusj-6369	116	18	to	to	PART
cusj-6369	116	19	be	be	AUX
cusj-6369	116	20	pag	pag	PROPN
cusj-6369	116	21	-	-	PUNCT
cusj-6369	116	22	speci"c	speci"c	PROPN
cusj-6369	116	23	,	,	PUNCT
cusj-6369	116	24	non	non	ADJ
cusj-6369	116	25	-	-	ADJ
cusj-6369	116	26	competitive	competitive	ADJ
cusj-6369	116	27	inhibitors	inhibitor	NOUN
cusj-6369	116	28	will	will	AUX
cusj-6369	116	29	be	be	AUX
cusj-6369	116	30	preferentially	preferentially	ADV
cusj-6369	116	31	selected	select	VERB
cusj-6369	116	32	for	for	ADP
cusj-6369	116	33	optimization	optimization	NOUN
cusj-6369	116	34	.	.	PUNCT
cusj-6369	117	1	once	once	SCONJ
cusj-6369	117	2	these	these	DET
cusj-6369	117	3	leads	lead	NOUN
cusj-6369	117	4	are	be	AUX
cusj-6369	117	5	optimized	optimize	VERB
cusj-6369	117	6	,	,	PUNCT
cusj-6369	117	7	they	they	PRON
cusj-6369	117	8	will	will	AUX
cusj-6369	117	9	be	be	AUX
cusj-6369	117	10	assessed	assess	VERB
cusj-6369	117	11	for	for	ADP
cusj-6369	117	12	drug	drug	NOUN
cusj-6369	117	13	-	-	PUNCT
cusj-6369	117	14	like	like	ADJ
cusj-6369	117	15	character	character	NOUN
cusj-6369	117	16	and	and	CCONJ
cusj-6369	117	17	their	their	PRON
cusj-6369	117	18	suitability	suitability	NOUN
cusj-6369	117	19	in	in	ADP
cusj-6369	117	20	the	the	DET
cusj-6369	117	21	pharmacotherapy	pharmacotherapy	NOUN
cusj-6369	117	22	of	of	ADP
cusj-6369	117	23	schizophrenia	schizophrenia	NOUN
cusj-6369	117	24	.	.	PUNCT
cusj-6369	118	1	for	for	ADP
cusj-6369	118	2	example	example	NOUN
cusj-6369	118	3	,	,	PUNCT
cusj-6369	118	4	pag	pag	PROPN
cusj-6369	118	5	activity	activity	NOUN
cusj-6369	118	6	measurements	measurement	NOUN
cusj-6369	118	7	in	in	ADP
cusj-6369	118	8	mice	mouse	NOUN
cusj-6369	118	9	administerd	administerd	VERB
cusj-6369	118	10	the	the	DET
cusj-6369	118	11	leads	lead	NOUN
cusj-6369	118	12	,	,	PUNCT
cusj-6369	118	13	electrophysiological	electrophysiological	ADJ
cusj-6369	118	14	recordings	recording	NOUN
cusj-6369	118	15	of	of	ADP
cusj-6369	118	16	their	their	PRON
cusj-6369	118	17	brain	brain	NOUN
cusj-6369	118	18	slices	slice	NOUN
cusj-6369	118	19	,	,	PUNCT
cusj-6369	118	20	and	and	CCONJ
cusj-6369	118	21	behavioral	behavioral	ADJ
cusj-6369	118	22	tests	test	NOUN
cusj-6369	118	23	analyzing	analyze	VERB
cusj-6369	118	24	their	their	PRON
cusj-6369	118	25	response	response	NOUN
cusj-6369	118	26	to	to	ADP
cusj-6369	118	27	amphetamine	amphetamine	NOUN
cusj-6369	118	28	-	-	PUNCT
cusj-6369	118	29	induced	induce	VERB
cusj-6369	118	30	hyperactivity	hyperactivity	NOUN
cusj-6369	118	31	can	can	AUX
cusj-6369	118	32	be	be	AUX
cusj-6369	118	33	used	use	VERB
cusj-6369	118	34	to	to	PART
cusj-6369	118	35	assess	assess	VERB
cusj-6369	118	36	the	the	DET
cusj-6369	118	37	value	value	NOUN
cusj-6369	118	38	of	of	ADP
cusj-6369	118	39	these	these	PRON
cusj-6369	118	40	leads	lead	VERB
cusj-6369	118	41	in	in	ADP
cusj-6369	118	42	pharmacotherapy	pharmacotherapy	NOUN
cusj-6369	118	43	.	.	PUNCT
cusj-6369	119	1	additionally	additionally	ADV
cusj-6369	119	2	,	,	PUNCT
cusj-6369	119	3	adme	adme	NOUN
cusj-6369	119	4	-	-	PUNCT
cusj-6369	119	5	tox	tox	NOUN
cusj-6369	119	6	(	(	PUNCT
cusj-6369	119	7	absorbtion	absorbtion	NOUN
cusj-6369	119	8	,	,	PUNCT
cusj-6369	119	9	distribution	distribution	NOUN
cusj-6369	119	10	,	,	PUNCT
cusj-6369	119	11	metabolism	metabolism	NOUN
cusj-6369	119	12	,	,	PUNCT
cusj-6369	119	13	excretion	excretion	NOUN
cusj-6369	119	14	,	,	PUNCT
cusj-6369	119	15	and	and	CCONJ
cusj-6369	119	16	toxicity	toxicity	NOUN
cusj-6369	119	17	)	)	PUNCT
cusj-6369	119	18	analysis	analysis	NOUN
cusj-6369	119	19	will	will	AUX
cusj-6369	119	20	be	be	AUX
cusj-6369	119	21	necessary	necessary	ADJ
cusj-6369	119	22	in	in	ADP
cusj-6369	119	23	assessing	assess	VERB
cusj-6369	119	24	suitability	suitability	NOUN
cusj-6369	119	25	for	for	ADP
cusj-6369	119	26	drug	drug	NOUN
cusj-6369	119	27	development	development	NOUN
cusj-6369	119	28	.	.	PUNCT
cusj-6369	120	1	cs	cs	PROPN
cusj-6369	120	2	thanks	thank	NOUN
cusj-6369	120	3	am	be	AUX
cusj-6369	120	4	and	and	CCONJ
cusj-6369	120	5	gk	gk	VERB
cusj-6369	120	6	for	for	ADP
cusj-6369	120	7	their	their	PRON
cusj-6369	120	8	guidance	guidance	NOUN
cusj-6369	120	9	and	and	CCONJ
cusj-6369	120	10	encouragement	encouragement	NOUN
cusj-6369	120	11	and	and	CCONJ
cusj-6369	120	12	sr	sr	PROPN
cusj-6369	120	13	for	for	ADP
cusj-6369	120	14	his	his	PRON
cusj-6369	120	15	mentorship	mentorship	NOUN
cusj-6369	120	16	,	,	PUNCT
cusj-6369	120	17	as	as	ADV
cusj-6369	120	18	well	well	ADV
cusj-6369	120	19	as	as	ADP
cusj-6369	120	20	all	all	DET
cusj-6369	120	21	the	the	DET
cusj-6369	120	22	collaborators	collaborator	NOUN
cusj-6369	120	23	for	for	ADP
cusj-6369	120	24	their	their	PRON
cusj-6369	120	25	support	support	NOUN
cusj-6369	120	26	and	and	CCONJ
cusj-6369	120	27	advice	advice	NOUN
cusj-6369	120	28	.	.	PUNCT
cusj-6369	121	1	cer	cer	PROPN
cusj-6369	121	2	,	,	PUNCT
cusj-6369	121	3	r.	r.	PROPN
cusj-6369	121	4	z.	z.	PROPN
cusj-6369	121	5	,	,	PUNCT
cusj-6369	121	6	mudunuri	mudunuri	PROPN
cusj-6369	121	7	,	,	PUNCT
cusj-6369	121	8	u.	u.	PROPN
cusj-6369	121	9	,	,	PUNCT
cusj-6369	121	10	stephens	stephens	PROPN
cusj-6369	121	11	,	,	PUNCT
cusj-6369	121	12	r.	r.	PROPN
cusj-6369	121	13	,	,	PUNCT
cusj-6369	121	14	and	and	CCONJ
cusj-6369	121	15	lebeda	lebeda	PROPN
cusj-6369	121	16	,	,	PUNCT
cusj-6369	121	17	f.	f.	PROPN
cusj-6369	121	18	j.	j.	PROPN
cusj-6369	121	19	(	(	PUNCT
cusj-6369	121	20	2009	2009	NUM
cusj-6369	121	21	)	)	PUNCT
cusj-6369	121	22	nucleicacids	nucleicacid	NOUN
cusj-6369	121	23	res	re	NOUN
cusj-6369	121	24	.	.	PROPN
cusj-6369	121	25	37	37	NUM
cusj-6369	121	26	,	,	PUNCT
cusj-6369	121	27	w441	w441	PROPN
cusj-6369	121	28	–	–	PUNCT
cusj-6369	121	29	w445	w445	PROPN
cusj-6369	121	30	copeland	copeland	PROPN
cusj-6369	121	31	,	,	PUNCT
cusj-6369	121	32	robert	robert	PROPN
cusj-6369	121	33	allen	allen	PROPN
cusj-6369	121	34	.	.	PUNCT
cusj-6369	122	1	enzymes	enzyme	NOUN
cusj-6369	122	2	:	:	PUNCT
cusj-6369	122	3	a	a	DET
cusj-6369	122	4	practical	practical	ADJ
cusj-6369	122	5	introduction	introduction	NOUN
cusj-6369	122	6	to	to	ADP
cusj-6369	122	7	structure	structure	NOUN
cusj-6369	122	8	,	,	PUNCT
cusj-6369	122	9	mechanism	mechanism	NOUN
cusj-6369	122	10	,	,	PUNCT
cusj-6369	122	11	and	and	CCONJ
cusj-6369	122	12	data	datum	NOUN
cusj-6369	122	13	analysis	analysis	NOUN
cusj-6369	122	14	.	.	PUNCT
cusj-6369	123	1	new	new	PROPN
cusj-6369	123	2	york	york	PROPN
cusj-6369	123	3	:	:	PUNCT
cusj-6369	123	4	wiley	wiley	PROPN
cusj-6369	123	5	,	,	PUNCT
cusj-6369	123	6	2000	2000	NUM
cusj-6369	123	7	.	.	PUNCT
cusj-6369	124	1	chiaradonna	chiaradonna	PROPN
cusj-6369	124	2	,	,	PUNCT
cusj-6369	124	3	f.	f.	PROPN
cusj-6369	124	4	,	,	PUNCT
cusj-6369	124	5	r.m	r.m	PROPN
cusj-6369	124	6	.	.	PROPN
cusj-6369	124	7	moresco	moresco	PROPN
cusj-6369	124	8	,	,	PUNCT
cusj-6369	124	9	c.	c.	PROPN
cusj-6369	124	10	airoldi	airoldi	PROPN
cusj-6369	124	11	,	,	PUNCT
cusj-6369	124	12	d.	d.	PROPN
cusj-6369	124	13	gaglio	gaglio	PROPN
cusj-6369	124	14	,	,	PUNCT
cusj-6369	124	15	r.	r.	PROPN
cusj-6369	124	16	palorini	palorini	PROPN
cusj-6369	124	17	,	,	PUNCT
cusj-6369	124	18	f.	f.	PROPN
cusj-6369	124	19	nicotra	nicotra	PROPN
cusj-6369	124	20	,	,	PUNCT
cusj-6369	124	21	c.	c.	PROPN
cusj-6369	124	22	messa	messa	PROPN
cusj-6369	124	23	,	,	PUNCT
cusj-6369	124	24	and	and	CCONJ
cusj-6369	124	25	l.	l.	PROPN
cusj-6369	124	26	alberghina	alberghina	PROPN
cusj-6369	124	27	.	.	PUNCT
cusj-6369	125	1	“	"	PUNCT
cusj-6369	125	2	from	from	ADP
cusj-6369	125	3	cancer	cancer	NOUN
cusj-6369	125	4	metabolism	metabolism	NOUN
cusj-6369	125	5	to	to	ADP
cusj-6369	125	6	new	new	ADJ
cusj-6369	125	7	biomarkers	biomarker	NOUN
cusj-6369	125	8	and	and	CCONJ
cusj-6369	125	9	drug	drug	NOUN
cusj-6369	125	10	targets	target	NOUN
cusj-6369	125	11	.	.	PUNCT
cusj-6369	125	12	”	"	PUNCT
cusj-6369	126	1	biotechnology	biotechnology	NOUN
cusj-6369	126	2	advances	advance	VERB
cusj-6369	126	3	30.1	30.1	NUM
cusj-6369	126	4	(	(	PUNCT
cusj-6369	126	5	2012	2012	NUM
cusj-6369	126	6	):	):	PUNCT
cusj-6369	126	7	30	30	NUM
cusj-6369	126	8	-	-	SYM
cusj-6369	126	9	51	51	NUM
cusj-6369	126	10	.	.	PUNCT
cusj-6369	127	1	creese	creese	PROPN
cusj-6369	127	2	,	,	PUNCT
cusj-6369	127	3	i.	i.	PROPN
cusj-6369	127	4	,	,	PUNCT
cusj-6369	127	5	d.	d.	PROPN
cusj-6369	127	6	burt	burt	PROPN
cusj-6369	127	7	,	,	PUNCT
cusj-6369	127	8	and	and	CCONJ
cusj-6369	127	9	s.	s.	PROPN
cusj-6369	127	10	snyder	snyder	PROPN
cusj-6369	127	11	.	.	PUNCT
cusj-6369	128	1	“	"	PUNCT
cusj-6369	128	2	dopamine	dopamine	NOUN
cusj-6369	128	3	receptor	receptor	NOUN
cusj-6369	128	4	binding	bind	VERB
cusj-6369	128	5	predicts	predict	NOUN
cusj-6369	128	6	clinical	clinical	ADJ
cusj-6369	128	7	and	and	CCONJ
cusj-6369	128	8	pharmacological	pharmacological	ADJ
cusj-6369	128	9	potencies	potency	NOUN
cusj-6369	128	10	of	of	ADP
cusj-6369	128	11	antischizophrenic	antischizophrenic	ADJ
cusj-6369	128	12	drugs	drug	NOUN
cusj-6369	128	13	.	.	PUNCT
cusj-6369	128	14	”	"	PUNCT
cusj-6369	129	1	science	science	NOUN
cusj-6369	129	2	192.4238	192.4238	NUM
cusj-6369	129	3	(	(	PUNCT
cusj-6369	129	4	1976	1976	NUM
cusj-6369	129	5	):	):	PUNCT
cusj-6369	129	6	481	481	NUM
cusj-6369	129	7	-	-	SYM
cusj-6369	129	8	83	83	NUM
cusj-6369	129	9	.	.	PUNCT
cusj-6369	130	1	davis	davis	PROPN
cusj-6369	130	2	,	,	PUNCT
cusj-6369	130	3	kenneth	kenneth	PROPN
cusj-6369	130	4	l.	l.	PROPN
cusj-6369	130	5	,	,	PUNCT
cusj-6369	130	6	rene	rene	PROPN
cusj-6369	130	7	s.	s.	PROPN
cusj-6369	130	8	kahn	kahn	PROPN
cusj-6369	130	9	,	,	PUNCT
cusj-6369	130	10	grant	grant	PROPN
cusj-6369	130	11	ko	ko	PROPN
cusj-6369	130	12	,	,	PUNCT
cusj-6369	130	13	and	and	CCONJ
cusj-6369	130	14	michael	michael	PROPN
cusj-6369	130	15	davidson	davidson	PROPN
cusj-6369	130	16	.	.	PUNCT
cusj-6369	131	1	“	"	PUNCT
cusj-6369	131	2	dopamine	dopamine	VERB
cusj-6369	131	3	in	in	ADP
cusj-6369	131	4	schizophrenia	schizophrenia	NOUN
cusj-6369	131	5	:	:	PUNCT
cusj-6369	131	6	a	a	DET
cusj-6369	131	7	review	review	NOUN
cusj-6369	131	8	and	and	CCONJ
cusj-6369	131	9	reconceptualization	reconceptualization	NOUN
cusj-6369	131	10	.	.	PUNCT
cusj-6369	131	11	”	"	PUNCT
cusj-6369	131	12	am	be	AUX
cusj-6369	131	13	j	j	PROPN
cusj-6369	131	14	psychiatry	psychiatry	NOUN
cusj-6369	131	15	148.11	148.11	NUM
cusj-6369	131	16	(	(	PUNCT
cusj-6369	131	17	1991	1991	NUM
cusj-6369	131	18	):	):	PUNCT
cusj-6369	131	19	1474	1474	NUM
cusj-6369	131	20	-	-	SYM
cusj-6369	131	21	486	486	NUM
cusj-6369	131	22	.	.	PUNCT
cusj-6369	132	1	dhawan	dhawan	PROPN
cusj-6369	132	2	,	,	PUNCT
cusj-6369	132	3	j.	j.	PROPN
cusj-6369	132	4	“	"	PUNCT
cusj-6369	132	5	a	a	DET
cusj-6369	132	6	new	new	ADJ
cusj-6369	132	7	look	look	NOUN
cusj-6369	132	8	at	at	ADP
cusj-6369	132	9	glutamate	glutamate	NOUN
cusj-6369	132	10	and	and	CCONJ
cusj-6369	132	11	ischemia	ischemia	NOUN
cusj-6369	132	12	:	:	PUNCT
cusj-6369	132	13	nmda	nmda	ADJ
cusj-6369	132	14	agonist	agonist	NOUN
cusj-6369	132	15	improves	improve	VERB
cusj-6369	132	16	long	long	ADJ
cusj-6369	132	17	-	-	PUNCT
cusj-6369	132	18	term	term	NOUN
cusj-6369	132	19	functional	functional	ADJ
cusj-6369	132	20	outcome	outcome	NOUN
cusj-6369	132	21	in	in	ADP
cusj-6369	132	22	a	a	DET
cusj-6369	132	23	rat	rat	NOUN
cusj-6369	132	24	model	model	NOUN
cusj-6369	132	25	of	of	ADP
cusj-6369	132	26	stroke	stroke	NOUN
cusj-6369	132	27	.	.	PUNCT
cusj-6369	132	28	”	"	PUNCT
cusj-6369	133	1	future	future	ADJ
cusj-6369	133	2	neurol	neurol	NOUN
cusj-6369	133	3	.	.	PUNCT
cusj-6369	134	1	6.6	6.6	NUM
cusj-6369	134	2	(	(	PUNCT
cusj-6369	134	3	2011	2011	NUM
cusj-6369	134	4	):	):	PUNCT
cusj-6369	134	5	823	823	NUM
cusj-6369	134	6	-	-	SYM
cusj-6369	134	7	34	34	NUM
cusj-6369	134	8	gaisler	gaisler	NOUN
cusj-6369	134	9	-	-	PUNCT
cusj-6369	134	10	salomon	salomon	NOUN
cusj-6369	134	11	,	,	PUNCT
cusj-6369	134	12	inna	inna	NOUN
cusj-6369	134	13	,	,	PUNCT
cusj-6369	134	14	gretchen	gretchen	PROPN
cusj-6369	134	15	m.	m.	PROPN
cusj-6369	134	16	miller	miller	PROPN
cusj-6369	134	17	,	,	PUNCT
cusj-6369	134	18	nao	nao	PROPN
cusj-6369	134	19	chuhma	chuhma	PROPN
cusj-6369	134	20	,	,	PUNCT
cusj-6369	134	21	sooyeon	sooyeon	PROPN
cusj-6369	134	22	lee	lee	PROPN
cusj-6369	134	23	,	,	PUNCT
cusj-6369	134	24	hong	hong	PROPN
cusj-6369	134	25	zhang	zhang	PROPN
cusj-6369	134	26	,	,	PUNCT
cusj-6369	134	27	farhad	farhad	PROPN
cusj-6369	134	28	ghoddoussi	ghoddoussi	PROPN
cusj-6369	134	29	,	,	PUNCT
cusj-6369	134	30	nicole	nicole	PROPN
cusj-6369	134	31	lewandowski	lewandowski	PROPN
cusj-6369	134	32	,	,	PUNCT
cusj-6369	134	33	stephen	stephen	PROPN
cusj-6369	134	34	fairhurst	fairhurst	PROPN
cusj-6369	134	35	,	,	PUNCT
cusj-6369	134	36	yvonne	yvonne	PROPN
cusj-6369	134	37	wang	wang	PROPN
cusj-6369	134	38	,	,	PUNCT
cusj-6369	134	39	agnès	agnès	PROPN
cusj-6369	134	40	conjard	conjard	PROPN
cusj-6369	134	41	-	-	PUNCT
cusj-6369	134	42	duplany	duplany	PROPN
cusj-6369	134	43	,	,	PUNCT
cusj-6369	134	44	justine	justine	PROPN
cusj-6369	134	45	masson	masson	PROPN
cusj-6369	134	46	,	,	PUNCT
cusj-6369	134	47	peter	peter	PROPN
cusj-6369	134	48	balsam	balsam	PROPN
cusj-6369	134	49	,	,	PUNCT
cusj-6369	134	50	rené	rené	PROPN
cusj-6369	134	51	hen	hen	PROPN
cusj-6369	134	52	,	,	PUNCT
cusj-6369	134	53	ottavio	ottavio	NOUN
cusj-6369	134	54	arancio	arancio	NOUN
cusj-6369	134	55	,	,	PUNCT
cusj-6369	134	56	matthew	matthew	PROPN
cusj-6369	134	57	p.	p.	PROPN
cusj-6369	134	58	galloway	galloway	PROPN
cusj-6369	134	59	,	,	PUNCT
cusj-6369	134	60	holly	holly	PROPN
cusj-6369	134	61	m.	m.	PROPN
cusj-6369	134	62	moore	moore	PROPN
cusj-6369	134	63	,	,	PUNCT
cusj-6369	134	64	scott	scott	PROPN
cusj-6369	134	65	a.	a.	PROPN
cusj-6369	134	66	small	small	PROPN
cusj-6369	134	67	,	,	PUNCT
cusj-6369	134	68	and	and	CCONJ
cusj-6369	134	69	stephen	stephen	PROPN
cusj-6369	134	70	rayport	rayport	PROPN
cusj-6369	134	71	.	.	PUNCT
cusj-6369	135	1	“	"	PUNCT
cusj-6369	135	2	glutaminase	glutaminase	NOUN
cusj-6369	135	3	-	-	PUNCT
cusj-6369	135	4	de"cient	de"cient	NOUN
cusj-6369	135	5	mice	mice	NOUN
cusj-6369	135	6	display	display	NOUN
cusj-6369	135	7	hippocampal	hippocampal	ADJ
cusj-6369	135	8	hypoactivity	hypoactivity	NOUN
cusj-6369	135	9	,	,	PUNCT
cusj-6369	135	10	insensitivity	insensitivity	NOUN
cusj-6369	135	11	to	to	ADP
cusj-6369	135	12	pro	pro	ADJ
cusj-6369	135	13	-	-	ADJ
cusj-6369	135	14	psychotic	psychotic	ADJ
cusj-6369	135	15	drugs	drug	NOUN
cusj-6369	135	16	and	and	CCONJ
cusj-6369	135	17	potentiated	potentiate	VERB
cusj-6369	135	18	latent	latent	NOUN
cusj-6369	135	19	inhibition	inhibition	NOUN
cusj-6369	135	20	:	:	PUNCT
cusj-6369	135	21	relevance	relevance	NOUN
cusj-6369	135	22	to	to	ADP
cusj-6369	135	23	schizophrenia	schizophrenia	NOUN
cusj-6369	135	24	.	.	PUNCT
cusj-6369	135	25	”	"	PUNCT
cusj-6369	136	1	neuropsychopharmacology	neuropsychopharmacology	PROPN
cusj-6369	136	2	34.10	34.10	NUM
cusj-6369	136	3	(	(	PUNCT
cusj-6369	136	4	2009	2009	NUM
cusj-6369	136	5	):	):	PUNCT
cusj-6369	136	6	2305	2305	NUM
cusj-6369	136	7	-	-	SYM
cusj-6369	136	8	322	322	NUM
cusj-6369	136	9	.	.	PUNCT
cusj-6369	136	10	hartwick	hartwick	PROPN
cusj-6369	136	11	,	,	PUNCT
cusj-6369	136	12	e.	e.	PROPN
cusj-6369	136	13	w.	w.	PROPN
cusj-6369	136	14	,	,	PUNCT
cusj-6369	136	15	and	and	CCONJ
cusj-6369	136	16	n.	n.	PROPN
cusj-6369	136	17	p.	p.	NOUN
cusj-6369	136	18	curthoys	curthoy	NOUN
cusj-6369	136	19	.	.	PUNCT
cusj-6369	137	1	“	"	PUNCT
cusj-6369	137	2	bptes	bpte	VERB
cusj-6369	137	3	inhibition	inhibition	NOUN
cusj-6369	137	4	of	of	ADP
cusj-6369	137	5	hga(124	hga(124	NOUN
cusj-6369	137	6	-	-	PUNCT
cusj-6369	137	7	551	551	NUM
cusj-6369	137	8	)	)	PUNCT
cusj-6369	137	9	,	,	PUNCT
cusj-6369	137	10	a	a	DET
cusj-6369	137	11	truncated	truncated	ADJ
cusj-6369	137	12	form	form	NOUN
cusj-6369	137	13	of	of	ADP
cusj-6369	137	14	human	human	ADJ
cusj-6369	137	15	kidneytype	kidneytype	NOUN
cusj-6369	137	16	glutaminase	glutaminase	NOUN
cusj-6369	137	17	.	.	PUNCT
cusj-6369	137	18	”	"	PUNCT
cusj-6369	138	1	j	j	PROPN
cusj-6369	138	2	enzyme	enzyme	NOUN
cusj-6369	138	3	inhib	inhib	VERB
cusj-6369	138	4	med	med	ADJ
cusj-6369	138	5	chem	chem	NOUN
cusj-6369	138	6	(	(	PUNCT
cusj-6369	138	7	2011	2011	NUM
cusj-6369	138	8	)	)	PUNCT
cusj-6369	138	9	.	.	PUNCT
cusj-6369	139	1	huang	huang	PROPN
cusj-6369	139	2	,	,	PUNCT
cusj-6369	139	3	y.	y.	PROPN
cusj-6369	139	4	,	,	PUNCT
cusj-6369	139	5	l.	l.	PROPN
cusj-6369	139	6	zhao	zhao	PROPN
cusj-6369	139	7	,	,	PUNCT
cusj-6369	139	8	b.	b.	PROPN
cusj-6369	139	9	jia	jia	PROPN
cusj-6369	139	10	,	,	PUNCT
cusj-6369	139	11	l.	l.	PROPN
cusj-6369	139	12	wu	wu	PROPN
cusj-6369	139	13	,	,	PUNCT
cusj-6369	139	14	y.	y.	PROPN
cusj-6369	139	15	li	li	PROPN
cusj-6369	139	16	,	,	PUNCT
cusj-6369	139	17	n.	n.	PROPN
cusj-6369	139	18	curthoys	curthoy	NOUN
cusj-6369	139	19	,	,	PUNCT
cusj-6369	139	20	and	and	CCONJ
cusj-6369	139	21	j.	j.	PROPN
cusj-6369	139	22	c.	c.	PROPN
cusj-6369	139	23	zheng	zheng	PROPN
cusj-6369	139	24	.	.	PUNCT
cusj-6369	140	1	“	"	PUNCT
cusj-6369	140	2	glutaminase	glutaminase	NOUN
cusj-6369	140	3	dysregulation	dysregulation	NOUN
cusj-6369	140	4	in	in	ADP
cusj-6369	140	5	hiv-1	hiv-1	ADV
cusj-6369	140	6	-	-	PUNCT
cusj-6369	140	7	infected	infect	VERB
cusj-6369	140	8	human	human	ADJ
cusj-6369	140	9	microglia	microglia	NOUN
cusj-6369	140	10	mediates	mediate	NOUN
cusj-6369	140	11	neurotoxicity	neurotoxicity	NOUN
cusj-6369	140	12	:	:	PUNCT
cusj-6369	140	13	relevant	relevant	ADJ
cusj-6369	140	14	to	to	ADP
cusj-6369	140	15	hiv1	hiv1	NOUN
cusj-6369	140	16	-	-	PUNCT
cusj-6369	140	17	associated	associate	VERB
cusj-6369	140	18	neurocognitive	neurocognitive	ADJ
cusj-6369	140	19	disorders	disorder	NOUN
cusj-6369	140	20	.	.	PUNCT
cusj-6369	140	21	”	"	PUNCT
cusj-6369	141	1	journal	journal	NOUN
cusj-6369	141	2	of	of	ADP
cusj-6369	141	3	neuroscience	neuroscience	NOUN
cusj-6369	141	4	31.42	31.42	NUM
cusj-6369	141	5	(	(	PUNCT
cusj-6369	141	6	2011	2011	NUM
cusj-6369	141	7	):	):	PUNCT
cusj-6369	141	8	15195	15195	NUM
cusj-6369	141	9	-	-	SYM
cusj-6369	141	10	5204	5204	NUM
cusj-6369	141	11	.	.	PUNCT
cusj-6369	142	1	javitt	javitt	PROPN
cusj-6369	142	2	,	,	PUNCT
cusj-6369	142	3	daniel	daniel	PROPN
cusj-6369	142	4	c.	c.	PROPN
cusj-6369	142	5	“	"	PUNCT
cusj-6369	142	6	glutamatergic	glutamatergic	ADJ
cusj-6369	142	7	#	#	ADJ
cusj-6369	142	8	eories	eorie	NOUN
cusj-6369	142	9	of	of	ADP
cusj-6369	142	10	schizophrenia	schizophrenia	NOUN
cusj-6369	142	11	.	.	PUNCT
cusj-6369	142	12	”	"	PUNCT
cusj-6369	143	1	isr	isr	PROPN
cusj-6369	143	2	j	j	PROPN
cusj-6369	143	3	psychiatry	psychiatry	PROPN
cusj-6369	143	4	relat	relat	PROPN
cusj-6369	143	5	sci	sci	PROPN
cusj-6369	143	6	47.1	47.1	NUM
cusj-6369	143	7	(	(	PUNCT
cusj-6369	143	8	2010	2010	NUM
cusj-6369	143	9	):	):	PUNCT
cusj-6369	143	10	4	4	NUM
cusj-6369	143	11	-	-	SYM
cusj-6369	143	12	16	16	NUM
cusj-6369	143	13	.	.	PUNCT
cusj-6369	144	1	jorgensen	jorgensen	PROPN
cusj-6369	144	2	wl	wl	PROPN
cusj-6369	144	3	.	.	PROPN
cusj-6369	144	4	acc	acc	PROPN
cusj-6369	144	5	chem	chem	NOUN
cusj-6369	144	6	res	re	NOUN
cusj-6369	144	7	.	.	PUNCT
cusj-6369	145	1	2009;42:724–733	2009;42:724–733	NOUN
cusj-6369	145	2	.	.	PUNCT
cusj-6369	146	1	kellendonk	kellendonk	PROPN
cusj-6369	146	2	c	c	NOUN
cusj-6369	146	3	,	,	PUNCT
cusj-6369	146	4	simpson	simpson	PROPN
cusj-6369	146	5	eh	eh	PROPN
cusj-6369	146	6	,	,	PUNCT
cusj-6369	146	7	polan	polan	PROPN
cusj-6369	146	8	hj	hj	PROPN
cusj-6369	146	9	,	,	PUNCT
cusj-6369	146	10	malleret	malleret	PROPN
cusj-6369	146	11	g	g	PROPN
cusj-6369	146	12	,	,	PUNCT
cusj-6369	146	13	vronskaya	vronskaya	NOUN
cusj-6369	146	14	s	s	PART
cusj-6369	146	15	,	,	PUNCT
cusj-6369	146	16	winiger	winiger	NOUN
cusj-6369	146	17	v	v	NOUN
cusj-6369	146	18	,	,	PUNCT
cusj-6369	146	19	moore	moore	PROPN
cusj-6369	146	20	h	h	PROPN
cusj-6369	146	21	,	,	PUNCT
cusj-6369	146	22	kandel	kandel	PROPN
cusj-6369	146	23	er	er	INTJ
cusj-6369	146	24	.	.	PUNCT
cusj-6369	146	25	transient	transient	PROPN
cusj-6369	146	26	and	and	CCONJ
cusj-6369	146	27	selective	selective	ADJ
cusj-6369	146	28	overexpression	overexpression	NOUN
cusj-6369	146	29	of	of	ADP
cusj-6369	146	30	dopamine	dopamine	NOUN
cusj-6369	146	31	d2	d2	NOUN
cusj-6369	146	32	receptors	receptor	NOUN
cusj-6369	146	33	in	in	ADP
cusj-6369	146	34	the	the	DET
cusj-6369	146	35	striatum	striatum	NOUN
cusj-6369	146	36	causes	cause	VERB
cusj-6369	146	37	persistent	persistent	ADJ
cusj-6369	146	38	abnormalities	abnormality	NOUN
cusj-6369	146	39	in	in	ADP
cusj-6369	146	40	prefrontal	prefrontal	ADJ
cusj-6369	146	41	cortex	cortex	NOUN
cusj-6369	146	42	functioning	functioning	NOUN
cusj-6369	146	43	.	.	PUNCT
cusj-6369	147	1	neuron	neuron	PROPN
cusj-6369	147	2	.	.	PUNCT
cusj-6369	148	1	2006;49:603–615	2006;49:603–615	X
cusj-6369	148	2	.	.	PUNCT
cusj-6369	149	1	matthysse	matthysse	PROPN
cusj-6369	149	2	s.	s.	PROPN
cusj-6369	149	3	antipsychotic	antipsychotic	PROPN
cusj-6369	149	4	drug	drug	PROPN
cusj-6369	149	5	actions	action	NOUN
cusj-6369	149	6	:	:	PUNCT
cusj-6369	149	7	a	a	DET
cusj-6369	149	8	clue	clue	NOUN
cusj-6369	149	9	to	to	ADP
cusj-6369	149	10	the	the	DET
cusj-6369	149	11	neuropathology	neuropathology	NOUN
cusj-6369	149	12	of	of	ADP
cusj-6369	149	13	schizophrenia.federation	schizophrenia.federation	NOUN
cusj-6369	149	14	proc	proc	NOUN
cusj-6369	149	15	.	.	PUNCT
cusj-6369	150	1	1973;32:200–208	1973;32:200–208	PROPN
cusj-6369	150	2	.	.	PUNCT
cusj-6369	150	3	mcelroy	mcelroy	PROPN
cusj-6369	150	4	,	,	PUNCT
cusj-6369	150	5	k.	k.	PUNCT
cusj-6369	151	1	“	"	PUNCT
cusj-6369	151	2	implementation	implementation	NOUN
cusj-6369	151	3	of	of	ADP
cusj-6369	151	4	a	a	DET
cusj-6369	151	5	continuous	continuous	ADJ
cusj-6369	151	6	,	,	PUNCT
cusj-6369	151	7	enzyme	enzyme	NOUN
cusj-6369	151	8	-	-	PUNCT
cusj-6369	151	9	coupled	couple	VERB
cusj-6369	151	10	fluorescence	fluorescence	NOUN
cusj-6369	151	11	assay	assay	VERB
cusj-6369	151	12	for	for	ADP
cusj-6369	151	13	high-#roughput	high-#roughput	ADJ
cusj-6369	151	14	analysis	analysis	NOUN
cusj-6369	151	15	of	of	ADP
cusj-6369	151	16	glutamate	glutamate	NOUN
cusj-6369	151	17	-	-	PUNCT
cusj-6369	151	18	producing	produce	VERB
cusj-6369	151	19	enzymes	enzyme	NOUN
cusj-6369	151	20	.	.	PUNCT
cusj-6369	151	21	”	"	PUNCT
cusj-6369	152	1	analytical	analytical	ADJ
cusj-6369	152	2	biochemistry	biochemistry	NOUN
cusj-6369	152	3	284.2	284.2	NUM
cusj-6369	152	4	(	(	PUNCT
cusj-6369	152	5	2000	2000	NUM
cusj-6369	152	6	):	):	PUNCT
cusj-6369	152	7	382	382	NUM
cusj-6369	152	8	-	-	SYM
cusj-6369	152	9	87	87	NUM
cusj-6369	152	10	.	.	PUNCT
cusj-6369	153	1	sanacora	sanacora	PROPN
cusj-6369	153	2	,	,	PUNCT
cusj-6369	153	3	gerard	gerard	PROPN
cusj-6369	153	4	,	,	PUNCT
cusj-6369	153	5	carlos	carlos	PROPN
cusj-6369	153	6	a.	a.	PROPN
cusj-6369	153	7	zarate	zarate	PROPN
cusj-6369	153	8	,	,	PUNCT
cusj-6369	153	9	john	john	PROPN
cusj-6369	153	10	h.	h.	PROPN
cusj-6369	153	11	krystal	krystal	PROPN
cusj-6369	153	12	,	,	PUNCT
cusj-6369	153	13	and	and	CCONJ
cusj-6369	153	14	husseini	husseini	PROPN
cusj-6369	153	15	k.	k.	PROPN
cusj-6369	153	16	manji	manji	PROPN
cusj-6369	153	17	.	.	PUNCT
cusj-6369	154	1	“	"	PUNCT
cusj-6369	154	2	targeting	target	VERB
cusj-6369	154	3	the	the	DET
cusj-6369	154	4	glutamatergic	glutamatergic	ADJ
cusj-6369	154	5	system	system	NOUN
cusj-6369	154	6	to	to	PART
cusj-6369	154	7	develop	develop	VERB
cusj-6369	154	8	novel	novel	NOUN
cusj-6369	154	9	,	,	PUNCT
cusj-6369	154	10	improved	improve	VERB
cusj-6369	154	11	#	#	SYM
cusj-6369	154	12	erapeutics	erapeutic	NOUN
cusj-6369	154	13	for	for	ADP
cusj-6369	154	14	mood	mood	NOUN
cusj-6369	154	15	disorders	disorder	NOUN
cusj-6369	154	16	.	.	PUNCT
cusj-6369	154	17	”	"	PUNCT
cusj-6369	155	1	nature	nature	NOUN
cusj-6369	155	2	reviews	review	VERB
cusj-6369	155	3	drug	drug	NOUN
cusj-6369	155	4	discovery	discovery	NOUN
cusj-6369	155	5	7.5	7.5	NUM
cusj-6369	155	6	(	(	PUNCT
cusj-6369	155	7	2008	2008	NUM
cusj-6369	155	8	):	):	PUNCT
cusj-6369	155	9	426	426	NUM
cusj-6369	155	10	-	-	SYM
cusj-6369	155	11	37	37	NUM
cusj-6369	155	12	.	.	PUNCT
cusj-6369	156	1	cusjcolumbia	cusjcolumbia	ADJ
cusj-6369	156	2	undergraduate	undergraduate	PROPN
cusj-6369	156	3	science	science	PROPN
cusj-6369	156	4	journal	journal	PROPN
cusj-6369	156	5	research	research	NOUN
cusj-6369	156	6	articles	article	NOUN
cusj-6369	156	7	8cusj	8cusj	NUM
cusj-6369	156	8	volume	volume	NOUN
cusj-6369	156	9	6spring	6spring	NUM
cusj-6369	156	10	2012	2012	NUM
cusj-6369	156	11	columbia	columbia	PROPN
cusj-6369	156	12	undergraduate	undergraduate	NOUN
cusj-6369	156	13	sci	sci	PROPN
cusj-6369	156	14	j	j	PROPN
cusj-6369	156	15	http://cusj.columbia.edu	http://cusj.columbia.edu	PROPN
cusj-6369	157	1	p	p	X
cusj-6369	157	2	s	s	AUX
cusj-6369	157	3	y	y	PROPN
cusj-6369	157	4	c	c	NOUN
cusj-6369	157	5	h	h	NOUN
cusj-6369	157	6	iatr	iatr	VERB
cusj-6369	157	7	y	y	PROPN
cusj-6369	157	8	discussion	discussion	NOUN
cusj-6369	157	9	acknowledgments	acknowledgment	NOUN
cusj-6369	157	10	references	reference	NOUN