id	sid	tid	token	lemma	pos
cusj-7788	1	1	55	55	NUM
cusj-7788	1	2	the	the	DET
cusj-7788	1	3	effects	effect	NOUN
cusj-7788	1	4	of	of	ADP
cusj-7788	1	5	apobec3	apobec3	ADP
cusj-7788	1	6	g	g	PROPN
cusj-7788	1	7	’s	’s	PART
cusj-7788	1	8	cytidine	cytidine	NOUN
cusj-7788	1	9	deaminase	deaminase	NOUN
cusj-7788	1	10	activity	activity	NOUN
cusj-7788	1	11	on	on	ADP
cusj-7788	1	12	retroviral	retroviral	ADJ
cusj-7788	1	13	evolution	evolution	NOUN
cusj-7788	1	14	mary	mary	PROPN
cusj-7788	1	15	-	-	PUNCT
cusj-7788	1	16	benedicta	benedicta	PROPN
cusj-7788	1	17	obikili1	obikili1	PROPN
cusj-7788	2	1	1department	1department	NUM
cusj-7788	2	2	of	of	ADP
cusj-7788	2	3	microbiology	microbiology	NOUN
cusj-7788	2	4	and	and	CCONJ
cusj-7788	2	5	immunology	immunology	NOUN
cusj-7788	2	6	,	,	PUNCT
cusj-7788	2	7	university	university	NOUN
cusj-7788	2	8	of	of	ADP
cusj-7788	2	9	illinois	illinois	PROPN
cusj-7788	2	10	at	at	ADP
cusj-7788	2	11	chicago	chicago	PROPN
cusj-7788	2	12	college	college	PROPN
cusj-7788	2	13	of	of	ADP
cusj-7788	2	14	medicine	medicine	NOUN
cusj-7788	2	15	,	,	PUNCT
cusj-7788	2	16	chicago	chicago	PROPN
cusj-7788	2	17	,	,	PUNCT
cusj-7788	2	18	il	il	PROPN
cusj-7788	2	19	,	,	PUNCT
cusj-7788	2	20	usa	usa	PROPN
cusj-7788	2	21	abstract	abstract	NOUN
cusj-7788	2	22	:	:	PUNCT
cusj-7788	3	1	apolipoprotein	apolipoprotein	VERB
cusj-7788	3	2	b	b	X
cusj-7788	3	3	editing	edit	VERB
cusj-7788	3	4	complex	complex	NOUN
cusj-7788	3	5	(	(	PUNCT
cusj-7788	3	6	apobec3	apobec3	NOUN
cusj-7788	3	7	/	/	SYM
cusj-7788	3	8	a3	a3	NOUN
cusj-7788	3	9	)	)	PUNCT
cusj-7788	3	10	genes	gene	NOUN
cusj-7788	3	11	are	be	AUX
cusj-7788	3	12	found	find	VERB
cusj-7788	3	13	in	in	ADP
cusj-7788	3	14	mammalian	mammalian	ADJ
cusj-7788	3	15	cells	cell	NOUN
cusj-7788	3	16	.	.	PUNCT
cusj-7788	4	1	in	in	ADP
cusj-7788	4	2	primates	primate	NOUN
cusj-7788	4	3	,	,	PUNCT
cusj-7788	4	4	there	there	PRON
cusj-7788	4	5	are	be	VERB
cusj-7788	4	6	7	7	NUM
cusj-7788	4	7	apobec3	apobec3	NOUN
cusj-7788	4	8	genes	gene	NOUN
cusj-7788	4	9	,	,	PUNCT
cusj-7788	4	10	namely	namely	ADV
cusj-7788	4	11	,	,	PUNCT
cusj-7788	4	12	3a	3a	NUM
cusj-7788	4	13	,	,	PUNCT
cusj-7788	4	14	3b	3b	NUM
cusj-7788	4	15	,	,	PUNCT
cusj-7788	4	16	3c	3c	NUM
cusj-7788	4	17	,	,	PUNCT
cusj-7788	4	18	3de	3de	ADJ
cusj-7788	4	19	,	,	PUNCT
cusj-7788	4	20	3f	3f	NUM
cusj-7788	4	21	,	,	PUNCT
cusj-7788	4	22	3	3	NUM
cusj-7788	4	23	g	g	NOUN
cusj-7788	4	24	,	,	PUNCT
cusj-7788	4	25	and	and	CCONJ
cusj-7788	4	26	3h	3h	NUM
cusj-7788	4	27	.	.	PUNCT
cusj-7788	5	1	previous	previous	ADJ
cusj-7788	5	2	research	research	NOUN
cusj-7788	5	3	has	have	AUX
cusj-7788	5	4	shown	show	VERB
cusj-7788	5	5	that	that	SCONJ
cusj-7788	5	6	a3	a3	NOUN
cusj-7788	5	7	proteins	protein	NOUN
cusj-7788	5	8	help	help	VERB
cusj-7788	5	9	to	to	PART
cusj-7788	5	10	inhibit	inhibit	VERB
cusj-7788	5	11	viral	viral	ADJ
cusj-7788	5	12	infection	infection	NOUN
cusj-7788	5	13	via	via	ADP
cusj-7788	5	14	their	their	PRON
cusj-7788	5	15	cytidine	cytidine	NOUN
cusj-7788	5	16	deaminase	deaminase	NOUN
cusj-7788	5	17	activity	activity	NOUN
cusj-7788	5	18	.	.	PUNCT
cusj-7788	6	1	however	however	ADV
cusj-7788	6	2	,	,	PUNCT
cusj-7788	6	3	it	it	PRON
cusj-7788	6	4	has	have	AUX
cusj-7788	6	5	also	also	ADV
cusj-7788	6	6	been	be	AUX
cusj-7788	6	7	found	find	VERB
cusj-7788	6	8	that	that	SCONJ
cusj-7788	6	9	a3	a3	NOUN
cusj-7788	6	10	proteins	protein	NOUN
cusj-7788	6	11	could	could	AUX
cusj-7788	6	12	lead	lead	VERB
cusj-7788	6	13	to	to	ADP
cusj-7788	6	14	viral	viral	ADJ
cusj-7788	6	15	evolution	evolution	NOUN
cusj-7788	6	16	,	,	PUNCT
cusj-7788	6	17	where	where	SCONJ
cusj-7788	6	18	retroviruses	retrovirus	NOUN
cusj-7788	6	19	such	such	ADJ
cusj-7788	6	20	as	as	ADP
cusj-7788	6	21	hiv	hiv	PROPN
cusj-7788	6	22	(	(	PUNCT
cusj-7788	6	23	human	human	ADJ
cusj-7788	6	24	immunodeficiency	immunodeficiency	NOUN
cusj-7788	6	25	virus	virus	NOUN
cusj-7788	6	26	)	)	PUNCT
cusj-7788	6	27	,	,	PUNCT
cusj-7788	6	28	acquire	acquire	VERB
cusj-7788	6	29	beneficial	beneficial	ADJ
cusj-7788	6	30	mutations	mutation	NOUN
cusj-7788	6	31	that	that	PRON
cusj-7788	6	32	enable	enable	VERB
cusj-7788	6	33	them	they	PRON
cusj-7788	6	34	to	to	PART
cusj-7788	6	35	overcome	overcome	VERB
cusj-7788	6	36	the	the	DET
cusj-7788	6	37	antiviral	antiviral	ADJ
cusj-7788	6	38	activity	activity	NOUN
cusj-7788	6	39	of	of	ADP
cusj-7788	6	40	a3	a3	NOUN
cusj-7788	6	41	proteins	protein	NOUN
cusj-7788	6	42	,	,	PUNCT
cusj-7788	6	43	gain	gain	VERB
cusj-7788	6	44	resistance	resistance	NOUN
cusj-7788	6	45	to	to	ADP
cusj-7788	6	46	certain	certain	ADJ
cusj-7788	6	47	drugs	drug	NOUN
cusj-7788	6	48	used	use	VERB
cusj-7788	6	49	for	for	ADP
cusj-7788	6	50	treating	treat	VERB
cusj-7788	6	51	viral	viral	ADJ
cusj-7788	6	52	infections	infection	NOUN
cusj-7788	6	53	and	and	CCONJ
cusj-7788	6	54	escape	escape	VERB
cusj-7788	6	55	recognition	recognition	NOUN
cusj-7788	6	56	by	by	ADP
cusj-7788	6	57	the	the	DET
cusj-7788	6	58	immune	immune	ADJ
cusj-7788	6	59	system	system	NOUN
cusj-7788	6	60	.	.	PUNCT
cusj-7788	7	1	this	this	DET
cusj-7788	7	2	paper	paper	NOUN
cusj-7788	7	3	is	be	AUX
cusj-7788	7	4	a	a	DET
cusj-7788	7	5	review	review	NOUN
cusj-7788	7	6	article	article	NOUN
cusj-7788	7	7	summarizing	summarize	VERB
cusj-7788	7	8	the	the	DET
cusj-7788	7	9	role	role	NOUN
cusj-7788	7	10	of	of	ADP
cusj-7788	7	11	a3	a3	NOUN
cusj-7788	7	12	g	g	NOUN
cusj-7788	7	13	on	on	ADP
cusj-7788	7	14	viral	viral	ADJ
cusj-7788	7	15	infection	infection	NOUN
cusj-7788	7	16	and	and	CCONJ
cusj-7788	7	17	evolution	evolution	NOUN
cusj-7788	7	18	,	,	PUNCT
cusj-7788	7	19	and	and	CCONJ
cusj-7788	7	20	the	the	DET
cusj-7788	7	21	potential	potential	ADJ
cusj-7788	7	22	impact	impact	NOUN
cusj-7788	7	23	viral	viral	ADJ
cusj-7788	7	24	evolution	evolution	NOUN
cusj-7788	7	25	could	could	AUX
cusj-7788	7	26	have	have	VERB
cusj-7788	7	27	in	in	ADP
cusj-7788	7	28	treatment	treatment	NOUN
cusj-7788	7	29	of	of	ADP
cusj-7788	7	30	retroviral	retroviral	ADJ
cusj-7788	7	31	infections	infection	NOUN
cusj-7788	7	32	such	such	ADJ
cusj-7788	7	33	as	as	ADP
cusj-7788	7	34	hiv	hiv	PROPN
cusj-7788	7	35	.	.	PUNCT
cusj-7788	8	1	keywords	keyword	NOUN
cusj-7788	8	2	:	:	PUNCT
cusj-7788	8	3	apobec3	apobec3	PROPN
cusj-7788	8	4	g	g	NOUN
cusj-7788	8	5	,	,	PUNCT
cusj-7788	8	6	cytidine	cytidine	NOUN
cusj-7788	8	7	deamination	deamination	NOUN
cusj-7788	8	8	,	,	PUNCT
cusj-7788	8	9	retroviral	retroviral	ADJ
cusj-7788	8	10	evolution	evolution	NOUN
cusj-7788	8	11	introduction	introduction	NOUN
cusj-7788	8	12	apolipoprotein	apolipoprotein	VERB
cusj-7788	8	13	bediting	bedite	VERB
cusj-7788	8	14	complex	complex	ADJ
cusj-7788	8	15	3	3	NUM
cusj-7788	8	16	(	(	PUNCT
cusj-7788	8	17	apobec3	apobec3	NOUN
cusj-7788	8	18	/	/	SYM
cusj-7788	8	19	a3	a3	NOUN
cusj-7788	8	20	)	)	PUNCT
cusj-7788	8	21	genes	gene	NOUN
cusj-7788	8	22	encode	encode	ADJ
cusj-7788	8	23	enzymes	enzyme	NOUN
cusj-7788	8	24	that	that	PRON
cusj-7788	8	25	prevent	prevent	VERB
cusj-7788	8	26	viral	viral	ADJ
cusj-7788	8	27	infection	infection	NOUN
cusj-7788	8	28	through	through	ADP
cusj-7788	8	29	their	their	PRON
cusj-7788	8	30	cytidine	cytidine	NOUN
cusj-7788	8	31	deaminase	deaminase	NOUN
cusj-7788	8	32	activity	activity	NOUN
cusj-7788	9	1	[	[	X
cusj-7788	9	2	1	1	NUM
cusj-7788	9	3	]	]	PUNCT
cusj-7788	9	4	.	.	PUNCT
cusj-7788	10	1	there	there	PRON
cusj-7788	10	2	are	be	VERB
cusj-7788	10	3	seven	seven	NUM
cusj-7788	10	4	apobec3	apobec3	NOUN
cusj-7788	10	5	genes	gene	NOUN
cusj-7788	10	6	found	find	VERB
cusj-7788	10	7	in	in	ADP
cusj-7788	10	8	humans	human	NOUN
cusj-7788	10	9	,	,	PUNCT
cusj-7788	10	10	namely	namely	ADV
cusj-7788	10	11	:	:	PUNCT
cusj-7788	10	12	a3a	a3a	ADJ
cusj-7788	10	13	,	,	PUNCT
cusj-7788	10	14	a3b	a3b	ADJ
cusj-7788	10	15	,	,	PUNCT
cusj-7788	10	16	a3c	a3c	VERB
cusj-7788	10	17	,	,	PUNCT
cusj-7788	10	18	a3de	a3de	CCONJ
cusj-7788	10	19	,	,	PUNCT
cusj-7788	10	20	a3f	a3f	ADJ
cusj-7788	10	21	,	,	PUNCT
cusj-7788	10	22	a3	a3	NOUN
cusj-7788	10	23	g	g	NOUN
cusj-7788	10	24	,	,	PUNCT
cusj-7788	10	25	and	and	CCONJ
cusj-7788	10	26	a3h	a3h	PROPN
cusj-7788	10	27	.	.	PUNCT
cusj-7788	11	1	most	most	ADJ
cusj-7788	11	2	of	of	ADP
cusj-7788	11	3	these	these	DET
cusj-7788	11	4	proteins	protein	NOUN
cusj-7788	11	5	play	play	VERB
cusj-7788	11	6	a	a	DET
cusj-7788	11	7	role	role	NOUN
cusj-7788	11	8	in	in	ADP
cusj-7788	11	9	inhibiting	inhibit	VERB
cusj-7788	11	10	viral	viral	ADJ
cusj-7788	11	11	infection	infection	NOUN
cusj-7788	11	12	,	,	PUNCT
cusj-7788	11	13	however	however	ADV
cusj-7788	11	14	,	,	PUNCT
cusj-7788	11	15	a3	a3	VERB
cusj-7788	11	16	g	g	NOUN
cusj-7788	11	17	,	,	PUNCT
cusj-7788	11	18	a3f	a3f	PROPN
cusj-7788	11	19	,	,	PUNCT
cusj-7788	11	20	a3d	a3d	PROPN
cusj-7788	11	21	,	,	PUNCT
cusj-7788	11	22	and	and	CCONJ
cusj-7788	11	23	a3h	a3h	NOUN
cusj-7788	11	24	are	be	AUX
cusj-7788	11	25	best	well	ADV
cusj-7788	11	26	known	know	VERB
cusj-7788	11	27	for	for	ADP
cusj-7788	11	28	their	their	PRON
cusj-7788	11	29	antiviral	antiviral	ADJ
cusj-7788	11	30	role	role	NOUN
cusj-7788	11	31	[	[	X
cusj-7788	11	32	2	2	NUM
cusj-7788	11	33	,	,	PUNCT
cusj-7788	11	34	3	3	NUM
cusj-7788	11	35	]	]	PUNCT
cusj-7788	11	36	.	.	PUNCT
cusj-7788	12	1	a3	a3	NOUN
cusj-7788	12	2	proteins	protein	NOUN
cusj-7788	12	3	can	can	AUX
cusj-7788	12	4	be	be	AUX
cusj-7788	12	5	found	find	VERB
cusj-7788	12	6	in	in	ADP
cusj-7788	12	7	human	human	ADJ
cusj-7788	12	8	and	and	CCONJ
cusj-7788	12	9	mouse	mouse	NOUN
cusj-7788	12	10	dendritic	dendritic	ADJ
cusj-7788	12	11	and	and	CCONJ
cusj-7788	12	12	myeloid	myeloid	ADJ
cusj-7788	12	13	cells	cell	NOUN
cusj-7788	12	14	,	,	PUNCT
cusj-7788	12	15	and	and	CCONJ
cusj-7788	12	16	they	they	PRON
cusj-7788	12	17	are	be	AUX
cusj-7788	12	18	usually	usually	ADV
cusj-7788	12	19	expressed	express	VERB
cusj-7788	12	20	at	at	ADP
cusj-7788	12	21	different	different	ADJ
cusj-7788	12	22	levels	level	NOUN
cusj-7788	12	23	in	in	ADP
cusj-7788	12	24	hematopoietic	hematopoietic	ADJ
cusj-7788	12	25	cell	cell	NOUN
cusj-7788	12	26	populations	population	NOUN
cusj-7788	12	27	,	,	PUNCT
cusj-7788	12	28	which	which	PRON
cusj-7788	12	29	include	include	VERB
cusj-7788	12	30	b	b	NOUN
cusj-7788	12	31	cells	cell	NOUN
cusj-7788	12	32	,	,	PUNCT
cusj-7788	12	33	cd4	cd4	PROPN
cusj-7788	12	34	+	+	PROPN
cusj-7788	12	35	and	and	CCONJ
cusj-7788	12	36	cd8	cd8	PROPN
cusj-7788	12	37	+	+	PROPN
cusj-7788	12	38	t	t	PROPN
cusj-7788	12	39	cells	cell	NOUN
cusj-7788	12	40	[	[	X
cusj-7788	12	41	1	1	NUM
cusj-7788	12	42	]	]	PUNCT
cusj-7788	12	43	.	.	PUNCT
cusj-7788	13	1	when	when	SCONJ
cusj-7788	13	2	a	a	DET
cusj-7788	13	3	host	host	NOUN
cusj-7788	13	4	cell	cell	NOUN
cusj-7788	13	5	is	be	AUX
cusj-7788	13	6	infected	infect	VERB
cusj-7788	13	7	,	,	PUNCT
cusj-7788	13	8	interferons	interferon	NOUN
cusj-7788	13	9	,	,	PUNCT
cusj-7788	13	10	and	and	CCONJ
cusj-7788	13	11	other	other	ADJ
cusj-7788	13	12	chemokines	chemokine	NOUN
cusj-7788	13	13	and	and	CCONJ
cusj-7788	13	14	cytokines	cytokine	NOUN
cusj-7788	13	15	are	be	AUX
cusj-7788	13	16	released	release	VERB
cusj-7788	13	17	and	and	CCONJ
cusj-7788	13	18	stimulate	stimulate	VERB
cusj-7788	13	19	the	the	DET
cusj-7788	13	20	expression	expression	NOUN
cusj-7788	13	21	of	of	ADP
cusj-7788	13	22	a3	a3	NOUN
cusj-7788	13	23	proteins	protein	NOUN
cusj-7788	13	24	in	in	ADP
cusj-7788	13	25	other	other	ADJ
cusj-7788	13	26	cells	cell	NOUN
cusj-7788	13	27	which	which	PRON
cusj-7788	13	28	help	help	VERB
cusj-7788	13	29	to	to	PART
cusj-7788	13	30	fight	fight	VERB
cusj-7788	13	31	off	off	ADP
cusj-7788	13	32	the	the	DET
cusj-7788	13	33	infection	infection	NOUN
cusj-7788	13	34	[	[	X
cusj-7788	13	35	1	1	NUM
cusj-7788	13	36	]	]	PUNCT
cusj-7788	13	37	.	.	PUNCT
cusj-7788	14	1	it	it	PRON
cusj-7788	14	2	has	have	AUX
cusj-7788	14	3	been	be	AUX
cusj-7788	14	4	found	find	VERB
cusj-7788	14	5	that	that	SCONJ
cusj-7788	14	6	a3	a3	NOUN
cusj-7788	14	7	proteins	protein	NOUN
cusj-7788	14	8	,	,	PUNCT
cusj-7788	14	9	specifically	specifically	ADV
cusj-7788	14	10	a3	a3	VERB
cusj-7788	14	11	g	g	NOUN
cusj-7788	14	12	,	,	PUNCT
cusj-7788	14	13	is	be	AUX
cusj-7788	14	14	the	the	DET
cusj-7788	14	15	main	main	ADJ
cusj-7788	14	16	antiviral	antiviral	ADJ
cusj-7788	14	17	protein	protein	NOUN
cusj-7788	14	18	in	in	ADP
cusj-7788	14	19	cd4	cd4	PROPN
cusj-7788	14	20	+	+	PROPN
cusj-7788	14	21	t	t	NOUN
cusj-7788	14	22	cells	cell	NOUN
cusj-7788	14	23	.	.	PUNCT
cusj-7788	15	1	therefore	therefore	ADV
cusj-7788	15	2	,	,	PUNCT
cusj-7788	15	3	when	when	SCONJ
cusj-7788	15	4	a	a	DET
cusj-7788	15	5	cell	cell	NOUN
cusj-7788	15	6	is	be	AUX
cusj-7788	15	7	infected	infect	VERB
cusj-7788	15	8	,	,	PUNCT
cusj-7788	15	9	a3	a3	NOUN
cusj-7788	15	10	g	g	PROPN
cusj-7788	15	11	levels	level	NOUN
cusj-7788	15	12	increase	increase	VERB
cusj-7788	15	13	,	,	PUNCT
cusj-7788	15	14	hence	hence	ADV
cusj-7788	15	15	inhibiting	inhibit	VERB
cusj-7788	15	16	viral	viral	ADJ
cusj-7788	15	17	replication	replication	NOUN
cusj-7788	15	18	by	by	ADP
cusj-7788	15	19	introducing	introduce	VERB
cusj-7788	15	20	more	more	ADJ
cusj-7788	15	21	g	g	NOUN
cusj-7788	15	22	to	to	ADP
cusj-7788	15	23	a	a	DET
cusj-7788	15	24	hypermutations	hypermutation	NOUN
cusj-7788	15	25	in	in	ADP
cusj-7788	15	26	the	the	DET
cusj-7788	15	27	virus	virus	NOUN
cusj-7788	15	28	[	[	X
cusj-7788	15	29	1	1	NUM
cusj-7788	15	30	]	]	PUNCT
cusj-7788	15	31	.	.	PUNCT
cusj-7788	16	1	these	these	DET
cusj-7788	16	2	a3	a3	NOUN
cusj-7788	16	3	proteins	protein	NOUN
cusj-7788	16	4	are	be	AUX
cusj-7788	16	5	packaged	package	VERB
cusj-7788	16	6	into	into	ADP
cusj-7788	16	7	the	the	DET
cusj-7788	16	8	virion	virion	NOUN
cusj-7788	16	9	,	,	PUNCT
cusj-7788	16	10	which	which	PRON
cusj-7788	16	11	lead	lead	VERB
cusj-7788	16	12	to	to	ADP
cusj-7788	16	13	viral	viral	ADJ
cusj-7788	16	14	inhibition	inhibition	NOUN
cusj-7788	16	15	through	through	ADP
cusj-7788	16	16	their	their	PRON
cusj-7788	16	17	cytidine	cytidine	NOUN
cusj-7788	16	18	deaminase	deaminase	NOUN
cusj-7788	16	19	activity	activity	NOUN
cusj-7788	16	20	.	.	PUNCT
cusj-7788	17	1	the	the	DET
cusj-7788	17	2	cytidine	cytidine	NOUN
cusj-7788	17	3	deaminase	deaminase	NOUN
cusj-7788	17	4	activity	activity	NOUN
cusj-7788	17	5	of	of	ADP
cusj-7788	17	6	a3	a3	NOUN
cusj-7788	17	7	proteins	protein	NOUN
cusj-7788	17	8	refers	refer	VERB
cusj-7788	17	9	to	to	ADP
cusj-7788	17	10	the	the	DET
cusj-7788	17	11	conversion	conversion	NOUN
cusj-7788	17	12	of	of	ADP
cusj-7788	17	13	cytosine	cytosine	NOUN
cusj-7788	17	14	to	to	ADP
cusj-7788	17	15	uracil	uracil	PROPN
cusj-7788	17	16	in	in	ADP
cusj-7788	17	17	single	single	ADJ
cusj-7788	17	18	-	-	PUNCT
cusj-7788	17	19	stranded	strand	VERB
cusj-7788	17	20	dna	dna	NOUN
cusj-7788	17	21	(	(	PUNCT
cusj-7788	17	22	fig	fig	NOUN
cusj-7788	17	23	.	.	PUNCT
cusj-7788	18	1	1a	1a	NOUN
cusj-7788	18	2	)	)	PUNCT
cusj-7788	18	3	.	.	PUNCT
cusj-7788	19	1	during	during	ADP
cusj-7788	19	2	the	the	DET
cusj-7788	19	3	process	process	NOUN
cusj-7788	19	4	of	of	ADP
cusj-7788	19	5	retrovirus	retrovirus	NOUN
cusj-7788	19	6	infection	infection	NOUN
cusj-7788	19	7	,	,	PUNCT
cusj-7788	19	8	the	the	DET
cusj-7788	19	9	virion	virion	NOUN
cusj-7788	19	10	enters	enter	VERB
cusj-7788	19	11	the	the	DET
cusj-7788	19	12	cell	cell	NOUN
cusj-7788	19	13	cytoplasm	cytoplasm	NOUN
cusj-7788	19	14	and	and	CCONJ
cusj-7788	19	15	uncoats	uncoat	VERB
cusj-7788	19	16	its	its	PRON
cusj-7788	19	17	viral	viral	ADJ
cusj-7788	19	18	rna	rna	NOUN
cusj-7788	19	19	(	(	PUNCT
cusj-7788	19	20	fig	fig	NOUN
cusj-7788	19	21	.	.	PUNCT
cusj-7788	19	22	1b	1b	NUM
cusj-7788	19	23	)	)	PUNCT
cusj-7788	19	24	.	.	PUNCT
cusj-7788	20	1	the	the	DET
cusj-7788	20	2	viral	viral	ADJ
cusj-7788	20	3	enzyme	enzyme	NOUN
cusj-7788	20	4	reverse	reverse	ADJ
cusj-7788	20	5	transcriptase	transcriptase	NOUN
cusj-7788	20	6	then	then	ADV
cusj-7788	20	7	uses	use	VERB
cusj-7788	20	8	the	the	DET
cusj-7788	20	9	rna	rna	NOUN
cusj-7788	20	10	as	as	ADP
cusj-7788	20	11	a	a	DET
cusj-7788	20	12	template	template	NOUN
cusj-7788	20	13	for	for	ADP
cusj-7788	20	14	making	make	VERB
cusj-7788	20	15	dna	dna	NOUN
cusj-7788	20	16	.	.	PUNCT
cusj-7788	21	1	however	however	ADV
cusj-7788	21	2	,	,	PUNCT
cusj-7788	21	3	during	during	ADP
cusj-7788	21	4	the	the	DET
cusj-7788	21	5	process	process	NOUN
cusj-7788	21	6	of	of	ADP
cusj-7788	21	7	reverse	reverse	ADJ
cusj-7788	21	8	transcription	transcription	NOUN
cusj-7788	21	9	,	,	PUNCT
cusj-7788	21	10	the	the	DET
cusj-7788	21	11	a3	a3	NOUN
cusj-7788	21	12	protein	protein	NOUN
cusj-7788	21	13	deaminates	deaminate	VERB
cusj-7788	21	14	the	the	DET
cusj-7788	21	15	cytidine	cytidine	NOUN
cusj-7788	21	16	residues	residue	NOUN
cusj-7788	21	17	of	of	ADP
cusj-7788	21	18	the	the	DET
cusj-7788	21	19	(	(	PUNCT
cusj-7788	21	20	-	-	PUNCT
cusj-7788	21	21	)	)	PUNCT
cusj-7788	21	22	strand	strand	NOUN
cusj-7788	21	23	vi	vi	ADP
cusj-7788	21	24	©	©	PROPN
cusj-7788	21	25	2021	2021	NUM
cusj-7788	21	26	obikili	obikili	NOUN
cusj-7788	21	27	.	.	PUNCT
cusj-7788	22	1	this	this	PRON
cusj-7788	22	2	is	be	AUX
cusj-7788	22	3	an	an	DET
cusj-7788	22	4	open	open	ADJ
cusj-7788	22	5	access	access	NOUN
cusj-7788	22	6	article	article	NOUN
cusj-7788	22	7	distributed	distribute	VERB
cusj-7788	22	8	under	under	ADP
cusj-7788	22	9	the	the	DET
cusj-7788	22	10	terms	term	NOUN
cusj-7788	22	11	of	of	ADP
cusj-7788	22	12	the	the	DET
cusj-7788	22	13	creative	creative	ADJ
cusj-7788	22	14	commons	common	NOUN
cusj-7788	22	15	attribution	attribution	NOUN
cusj-7788	22	16	license	license	NOUN
cusj-7788	22	17	,	,	PUNCT
cusj-7788	22	18	which	which	PRON
cusj-7788	22	19	permits	permit	VERB
cusj-7788	22	20	the	the	DET
cusj-7788	22	21	user	user	NOUN
cusj-7788	22	22	to	to	PART
cusj-7788	22	23	copy	copy	VERB
cusj-7788	22	24	,	,	PUNCT
cusj-7788	22	25	distribute	distribute	VERB
cusj-7788	22	26	,	,	PUNCT
cusj-7788	22	27	and	and	CCONJ
cusj-7788	22	28	transmit	transmit	VERB
cusj-7788	22	29	the	the	DET
cusj-7788	22	30	work	work	NOUN
cusj-7788	22	31	provided	provide	VERB
cusj-7788	22	32	that	that	SCONJ
cusj-7788	22	33	the	the	DET
cusj-7788	22	34	original	original	ADJ
cusj-7788	22	35	authors	author	NOUN
cusj-7788	22	36	and	and	CCONJ
cusj-7788	22	37	source	source	NOUN
cusj-7788	22	38	are	be	AUX
cusj-7788	22	39	credited	credit	VERB
cusj-7788	22	40	.	.	PUNCT
cusj-7788	23	1	columbia	columbia	PROPN
cusj-7788	23	2	undergraduate	undergraduate	PROPN
cusj-7788	23	3	science	science	PROPN
cusj-7788	23	4	journal	journal	PROPN
cusj-7788	23	5	vol	vol	NOUN
cusj-7788	23	6	.	.	PROPN
cusj-7788	23	7	15	15	NUM
cusj-7788	23	8	,	,	PUNCT
cusj-7788	23	9	2021	2021	NUM
cusj-7788	23	10	obikili	obikili	NOUN
cusj-7788	23	11	.	.	PUNCT
cusj-7788	24	1	56	56	NUM
cusj-7788	24	2	ral	ral	ADJ
cusj-7788	24	3	dna	dna	NOUN
cusj-7788	24	4	to	to	ADP
cusj-7788	24	5	uracil	uracil	ADJ
cusj-7788	24	6	residues	residue	NOUN
cusj-7788	24	7	,	,	PUNCT
cusj-7788	24	8	resulting	result	VERB
cusj-7788	24	9	in	in	ADP
cusj-7788	24	10	g	g	NOUN
cusj-7788	24	11	-	-	PUNCT
cusj-7788	24	12	to	to	ADP
cusj-7788	24	13	-	-	PUNCT
cusj-7788	24	14	a	a	DET
cusj-7788	24	15	mutations	mutation	NOUN
cusj-7788	24	16	in	in	ADP
cusj-7788	24	17	the	the	DET
cusj-7788	24	18	viral	viral	ADJ
cusj-7788	24	19	coding	code	VERB
cusj-7788	24	20	(	(	PUNCT
cusj-7788	24	21	+	+	NOUN
cusj-7788	24	22	)	)	PUNCT
cusj-7788	24	23	strand	strand	NOUN
cusj-7788	24	24	dna	dna	PROPN
cusj-7788	24	25	.	.	PUNCT
cusj-7788	25	1	in	in	ADP
cusj-7788	25	2	other	other	ADJ
cusj-7788	25	3	words	word	NOUN
cusj-7788	25	4	,	,	PUNCT
cusj-7788	25	5	because	because	SCONJ
cusj-7788	25	6	cytidine	cytidine	NOUN
cusj-7788	25	7	is	be	AUX
cusj-7788	25	8	converted	convert	VERB
cusj-7788	25	9	to	to	ADP
cusj-7788	25	10	uracil	uracil	NOUN
cusj-7788	25	11	,	,	PUNCT
cusj-7788	25	12	which	which	PRON
cusj-7788	25	13	reverse	reverse	VERB
cusj-7788	25	14	transcriptase	transcriptase	NOUN
cusj-7788	25	15	reads	read	NOUN
cusj-7788	25	16	as	as	ADP
cusj-7788	25	17	thymidine	thymidine	NOUN
cusj-7788	25	18	,	,	PUNCT
cusj-7788	25	19	guanosine	guanosine	NOUN
cusj-7788	25	20	is	be	AUX
cusj-7788	25	21	replaced	replace	VERB
cusj-7788	25	22	with	with	ADP
cusj-7788	25	23	adenine	adenine	NOUN
cusj-7788	25	24	in	in	ADP
cusj-7788	25	25	the	the	DET
cusj-7788	25	26	viral	viral	ADJ
cusj-7788	25	27	coding	code	VERB
cusj-7788	25	28	strand	strand	NOUN
cusj-7788	26	1	dna	dna	PROPN
cusj-7788	26	2	.	.	PUNCT
cusj-7788	27	1	after	after	ADP
cusj-7788	27	2	the	the	DET
cusj-7788	27	3	synthesis	synthesis	NOUN
cusj-7788	27	4	of	of	ADP
cusj-7788	27	5	a	a	DET
cusj-7788	27	6	double	double	ADJ
cusj-7788	27	7	stranded	strand	VERB
cusj-7788	27	8	dna	dna	NOUN
cusj-7788	27	9	molecule	molecule	NOUN
cusj-7788	27	10	,	,	PUNCT
cusj-7788	27	11	the	the	DET
cusj-7788	27	12	viral	viral	ADJ
cusj-7788	27	13	dna	dna	NOUN
cusj-7788	27	14	goes	go	VERB
cusj-7788	27	15	into	into	ADP
cusj-7788	27	16	the	the	DET
cusj-7788	27	17	host	host	NOUN
cusj-7788	27	18	cell	cell	NOUN
cusj-7788	27	19	’s	’s	PART
cusj-7788	27	20	nucleus	nucleus	NOUN
cusj-7788	27	21	and	and	CCONJ
cusj-7788	27	22	becomes	becomes	AUX
cusj-7788	27	23	integrated	integrate	VERB
cusj-7788	27	24	in	in	ADP
cusj-7788	27	25	the	the	DET
cusj-7788	27	26	chromosomes	chromosome	NOUN
cusj-7788	27	27	(	(	PUNCT
cusj-7788	27	28	fig	fig	NOUN
cusj-7788	27	29	.	.	PUNCT
cusj-7788	28	1	1b	1b	NUM
cusj-7788	28	2	)	)	PUNCT
cusj-7788	28	3	.	.	PUNCT
cusj-7788	29	1	the	the	DET
cusj-7788	29	2	a3	a3	NOUN
cusj-7788	29	3	-	-	PUNCT
cusj-7788	29	4	induced	induce	VERB
cusj-7788	29	5	mutations	mutation	NOUN
cusj-7788	29	6	inhibit	inhibit	VERB
cusj-7788	29	7	the	the	DET
cusj-7788	29	8	synthesis	synthesis	NOUN
cusj-7788	29	9	of	of	ADP
cusj-7788	29	10	virus	virus	NOUN
cusj-7788	29	11	proteins	protein	NOUN
cusj-7788	29	12	and	and	CCONJ
cusj-7788	29	13	virions	virion	NOUN
cusj-7788	29	14	because	because	SCONJ
cusj-7788	29	15	they	they	PRON
cusj-7788	29	16	inactivate	inactivate	VERB
cusj-7788	29	17	the	the	DET
cusj-7788	29	18	virus	virus	NOUN
cusj-7788	29	19	,	,	PUNCT
cusj-7788	29	20	which	which	PRON
cusj-7788	29	21	prevents	prevent	VERB
cusj-7788	29	22	it	it	PRON
cusj-7788	29	23	from	from	ADP
cusj-7788	29	24	infecting	infect	VERB
cusj-7788	29	25	and	and	CCONJ
cusj-7788	29	26	replicating	replicate	VERB
cusj-7788	29	27	in	in	ADP
cusj-7788	29	28	other	other	ADJ
cusj-7788	29	29	cells	cell	NOUN
cusj-7788	29	30	.	.	PUNCT
cusj-7788	30	1	although	although	SCONJ
cusj-7788	30	2	apobec3	apobec3	NOUN
cusj-7788	30	3	proteins	protein	NOUN
cusj-7788	30	4	help	help	AUX
cusj-7788	30	5	inhibit	inhibit	VERB
cusj-7788	30	6	viral	viral	ADJ
cusj-7788	30	7	infection	infection	NOUN
cusj-7788	30	8	through	through	ADP
cusj-7788	30	9	their	their	PRON
cusj-7788	30	10	cytidine	cytidine	NOUN
cusj-7788	30	11	deaminase	deaminase	NOUN
cusj-7788	30	12	activity	activity	NOUN
cusj-7788	30	13	,	,	PUNCT
cusj-7788	30	14	a3d	a3d	PROPN
cusj-7788	30	15	,	,	PUNCT
cusj-7788	30	16	a3f	a3f	ADJ
cusj-7788	30	17	,	,	PUNCT
cusj-7788	30	18	a3	a3	NOUN
cusj-7788	30	19	g	g	NOUN
cusj-7788	30	20	,	,	PUNCT
cusj-7788	30	21	and	and	CCONJ
cusj-7788	30	22	a3h	a3h	NOUN
cusj-7788	30	23	may	may	AUX
cusj-7788	30	24	also	also	ADV
cusj-7788	30	25	play	play	VERB
cusj-7788	30	26	a	a	DET
cusj-7788	30	27	role	role	NOUN
cusj-7788	30	28	in	in	ADP
cusj-7788	30	29	viral	viral	ADJ
cusj-7788	30	30	evolution	evolution	NOUN
cusj-7788	30	31	,	,	PUNCT
cusj-7788	30	32	where	where	SCONJ
cusj-7788	30	33	viruses	virus	NOUN
cusj-7788	30	34	such	such	ADJ
cusj-7788	30	35	as	as	ADP
cusj-7788	30	36	hiv	hiv	PROPN
cusj-7788	30	37	gain	gain	VERB
cusj-7788	30	38	beneficial	beneficial	ADJ
cusj-7788	30	39	mutations	mutation	NOUN
cusj-7788	30	40	that	that	PRON
cusj-7788	30	41	enable	enable	VERB
cusj-7788	30	42	them	they	PRON
cusj-7788	30	43	to	to	PART
cusj-7788	30	44	overcome	overcome	VERB
cusj-7788	30	45	the	the	DET
cusj-7788	30	46	antiviral	antiviral	ADJ
cusj-7788	30	47	activity	activity	NOUN
cusj-7788	30	48	of	of	ADP
cusj-7788	30	49	a3	a3	NOUN
cusj-7788	30	50	proteins	protein	NOUN
cusj-7788	30	51	[	[	X
cusj-7788	30	52	5	5	NUM
cusj-7788	30	53	,	,	PUNCT
cusj-7788	30	54	6	6	NUM
cusj-7788	30	55	]	]	PUNCT
cusj-7788	30	56	.	.	PUNCT
cusj-7788	31	1	this	this	DET
cusj-7788	31	2	paper	paper	NOUN
cusj-7788	31	3	will	will	AUX
cusj-7788	31	4	highlight	highlight	VERB
cusj-7788	31	5	the	the	DET
cusj-7788	31	6	role	role	NOUN
cusj-7788	31	7	of	of	ADP
cusj-7788	31	8	a3	a3	NOUN
cusj-7788	31	9	proteins	protein	NOUN
cusj-7788	31	10	,	,	PUNCT
cusj-7788	31	11	specifically	specifically	ADV
cusj-7788	31	12	a3	a3	VERB
cusj-7788	31	13	g	g	NOUN
cusj-7788	31	14	,	,	PUNCT
cusj-7788	31	15	on	on	ADP
cusj-7788	31	16	retroviral	retroviral	ADJ
cusj-7788	31	17	evolution	evolution	NOUN
cusj-7788	31	18	.	.	PUNCT
cusj-7788	32	1	retrovirus	retrovirus	NOUN
cusj-7788	32	2	replication	replication	NOUN
cusj-7788	32	3	viruses	virus	NOUN
cusj-7788	32	4	are	be	AUX
cusj-7788	32	5	infectious	infectious	ADJ
cusj-7788	32	6	pathogens	pathogen	NOUN
cusj-7788	32	7	that	that	PRON
cusj-7788	32	8	require	require	VERB
cusj-7788	32	9	a	a	DET
cusj-7788	32	10	host	host	NOUN
cusj-7788	32	11	cell	cell	NOUN
cusj-7788	32	12	for	for	ADP
cusj-7788	32	13	their	their	PRON
cusj-7788	32	14	growth	growth	NOUN
cusj-7788	32	15	and	and	CCONJ
cusj-7788	32	16	replication	replication	NOUN
cusj-7788	32	17	.	.	PUNCT
cusj-7788	33	1	alfigure	alfigure	NOUN
cusj-7788	33	2	1	1	NUM
cusj-7788	33	3	:	:	PUNCT
cusj-7788	33	4	the	the	DET
cusj-7788	33	5	process	process	NOUN
cusj-7788	33	6	of	of	ADP
cusj-7788	33	7	cytidine	cytidine	NOUN
cusj-7788	33	8	deamination	deamination	NOUN
cusj-7788	33	9	.	.	PUNCT
cusj-7788	34	1	(	(	PUNCT
cusj-7788	34	2	a	a	X
cusj-7788	34	3	)	)	PUNCT
cusj-7788	34	4	the	the	DET
cusj-7788	34	5	enzyme	enzyme	NOUN
cusj-7788	34	6	apobec3	apobec3	ADV
cusj-7788	34	7	,	,	PUNCT
cusj-7788	34	8	which	which	PRON
cusj-7788	34	9	is	be	AUX
cusj-7788	34	10	a	a	DET
cusj-7788	34	11	cytidine	cytidine	NOUN
cusj-7788	34	12	deaminase	deaminase	NOUN
cusj-7788	34	13	,	,	PUNCT
cusj-7788	34	14	deaminates	deaminate	VERB
cusj-7788	34	15	cytidine	cytidine	NOUN
cusj-7788	34	16	to	to	ADP
cusj-7788	34	17	uridine	uridine	NOUN
cusj-7788	34	18	in	in	ADP
cusj-7788	34	19	the	the	DET
cusj-7788	34	20	single	single	ADJ
cusj-7788	34	21	-	-	PUNCT
cusj-7788	34	22	stranded	strand	VERB
cusj-7788	34	23	retroviral	retroviral	ADJ
cusj-7788	34	24	dna	dna	NOUN
cusj-7788	34	25	before	before	ADP
cusj-7788	34	26	its	its	PRON
cusj-7788	34	27	integration	integration	NOUN
cusj-7788	34	28	into	into	ADP
cusj-7788	34	29	the	the	DET
cusj-7788	34	30	host	host	NOUN
cusj-7788	34	31	cell	cell	NOUN
cusj-7788	34	32	(	(	PUNCT
cusj-7788	34	33	source	source	NOUN
cusj-7788	34	34	:	:	PUNCT
cusj-7788	34	35	national	national	PROPN
cusj-7788	34	36	university	university	PROPN
cusj-7788	34	37	of	of	ADP
cusj-7788	34	38	singapore	singapore	PROPN
cusj-7788	34	39	,	,	PUNCT
cusj-7788	34	40	faculty	faculty	NOUN
cusj-7788	34	41	of	of	ADP
cusj-7788	34	42	science	science	NOUN
cusj-7788	34	43	,	,	PUNCT
cusj-7788	34	44	special	special	ADJ
cusj-7788	34	45	programme	programme	NOUN
cusj-7788	34	46	in	in	ADP
cusj-7788	34	47	science	science	NOUN
cusj-7788	34	48	and	and	CCONJ
cusj-7788	34	49	igem	igem	NOUN
cusj-7788	34	50	2018	2018	NUM
cusj-7788	34	51	,	,	PUNCT
cusj-7788	34	52	yuhui	yuhui	PROPN
cusj-7788	34	53	deborah	deborah	PROPN
cusj-7788	34	54	fong	fong	PROPN
cusj-7788	34	55	(	(	PUNCT
cusj-7788	34	56	used	use	VERB
cusj-7788	34	57	with	with	ADP
cusj-7788	34	58	permission	permission	NOUN
cusj-7788	34	59	)	)	PUNCT
cusj-7788	34	60	)	)	PUNCT
cusj-7788	35	1	(	(	PUNCT
cusj-7788	35	2	b	b	X
cusj-7788	35	3	)	)	PUNCT
cusj-7788	35	4	the	the	DET
cusj-7788	35	5	virus	virus	NOUN
cusj-7788	35	6	enters	enter	VERB
cusj-7788	35	7	the	the	DET
cusj-7788	35	8	cell	cell	NOUN
cusj-7788	35	9	.	.	PUNCT
cusj-7788	36	1	after	after	ADP
cusj-7788	36	2	uncoating	uncoate	VERB
cusj-7788	36	3	of	of	ADP
cusj-7788	36	4	the	the	DET
cusj-7788	36	5	rna	rna	NOUN
cusj-7788	36	6	genome	genome	NOUN
cusj-7788	36	7	,	,	PUNCT
cusj-7788	36	8	the	the	DET
cusj-7788	36	9	viral	viral	ADJ
cusj-7788	36	10	enzyme	enzyme	NOUN
cusj-7788	36	11	,	,	PUNCT
cusj-7788	36	12	reverse	reverse	ADJ
cusj-7788	36	13	transcriptase	transcriptase	NOUN
cusj-7788	36	14	makes	make	VERB
cusj-7788	36	15	a	a	DET
cusj-7788	36	16	double	double	ADJ
cusj-7788	36	17	-	-	PUNCT
cusj-7788	36	18	stranded	strand	VERB
cusj-7788	36	19	dna	dna	PROPN
cusj-7788	36	20	copy	copy	NOUN
cusj-7788	36	21	of	of	ADP
cusj-7788	36	22	the	the	DET
cusj-7788	36	23	genome	genome	NOUN
cusj-7788	36	24	,	,	PUNCT
cusj-7788	36	25	which	which	PRON
cusj-7788	36	26	then	then	ADV
cusj-7788	36	27	enters	enter	VERB
cusj-7788	36	28	the	the	DET
cusj-7788	36	29	nucleus	nucleus	NOUN
cusj-7788	36	30	and	and	CCONJ
cusj-7788	36	31	integrates	integrate	NOUN
cusj-7788	36	32	into	into	ADP
cusj-7788	36	33	the	the	DET
cusj-7788	36	34	host	host	NOUN
cusj-7788	36	35	chromosomes	chromosome	NOUN
cusj-7788	36	36	.	.	PUNCT
cusj-7788	37	1	during	during	ADP
cusj-7788	37	2	reverse	reverse	ADJ
cusj-7788	37	3	transcription	transcription	NOUN
cusj-7788	37	4	,	,	PUNCT
cusj-7788	37	5	a3	a3	NOUN
cusj-7788	37	6	enzymes	enzyme	NOUN
cusj-7788	37	7	(	(	PUNCT
cusj-7788	37	8	red	red	ADJ
cusj-7788	37	9	ball	ball	NOUN
cusj-7788	37	10	)	)	PUNCT
cusj-7788	37	11	,	,	PUNCT
cusj-7788	37	12	which	which	PRON
cusj-7788	37	13	are	be	AUX
cusj-7788	37	14	packaged	package	VERB
cusj-7788	37	15	in	in	ADP
cusj-7788	37	16	the	the	DET
cusj-7788	37	17	virion	virion	NOUN
cusj-7788	37	18	deaminates	deaminate	VERB
cusj-7788	37	19	cytidine	cytidine	NOUN
cusj-7788	37	20	to	to	ADP
cusj-7788	37	21	uracil	uracil	PROPN
cusj-7788	37	22	in	in	ADP
cusj-7788	37	23	the	the	DET
cusj-7788	37	24	single	single	ADJ
cusj-7788	37	25	-	-	PUNCT
cusj-7788	37	26	stranded	strand	VERB
cusj-7788	37	27	viral	viral	ADJ
cusj-7788	37	28	dna	dna	NOUN
cusj-7788	37	29	before	before	ADP
cusj-7788	37	30	its	its	PRON
cusj-7788	37	31	replication	replication	NOUN
cusj-7788	37	32	and	and	CCONJ
cusj-7788	37	33	integration	integration	NOUN
cusj-7788	37	34	into	into	ADP
cusj-7788	37	35	the	the	DET
cusj-7788	37	36	chromosomes	chromosome	NOUN
cusj-7788	37	37	,	,	PUNCT
cusj-7788	37	38	resulting	result	VERB
cusj-7788	37	39	in	in	ADP
cusj-7788	37	40	g	g	NOUN
cusj-7788	37	41	-	-	PUNCT
cusj-7788	37	42	to	to	ADP
cusj-7788	37	43	-	-	PUNCT
cusj-7788	37	44	a	a	DET
cusj-7788	37	45	changes	change	NOUN
cusj-7788	37	46	in	in	ADP
cusj-7788	37	47	the	the	DET
cusj-7788	37	48	viral	viral	ADJ
cusj-7788	37	49	genome	genome	NOUN
cusj-7788	37	50	.	.	PUNCT
cusj-7788	38	1	the	the	DET
cusj-7788	38	2	red	red	ADJ
cusj-7788	38	3	dna	dna	PROPN
cusj-7788	38	4	in	in	ADP
cusj-7788	38	5	the	the	DET
cusj-7788	38	6	nucleus	nucleus	NOUN
cusj-7788	38	7	is	be	AUX
cusj-7788	38	8	the	the	DET
cusj-7788	38	9	integrated	integrated	ADJ
cusj-7788	38	10	viral	viral	ADJ
cusj-7788	38	11	dna	dna	NOUN
cusj-7788	38	12	.	.	PUNCT
cusj-7788	39	1	figure	figure	NOUN
cusj-7788	39	2	2	2	NUM
cusj-7788	39	3	:	:	PUNCT
cusj-7788	39	4	retrovirus	retrovirus	NOUN
cusj-7788	39	5	life	life	NOUN
cusj-7788	39	6	cycle	cycle	NOUN
cusj-7788	39	7	this	this	PRON
cusj-7788	39	8	shows	show	VERB
cusj-7788	39	9	the	the	DET
cusj-7788	39	10	process	process	NOUN
cusj-7788	39	11	of	of	ADP
cusj-7788	39	12	retroviral	retroviral	ADJ
cusj-7788	39	13	integration	integration	NOUN
cusj-7788	39	14	and	and	CCONJ
cusj-7788	39	15	replication	replication	NOUN
cusj-7788	39	16	in	in	ADP
cusj-7788	39	17	the	the	DET
cusj-7788	39	18	host	host	NOUN
cusj-7788	39	19	cell	cell	NOUN
cusj-7788	39	20	.	.	PUNCT
cusj-7788	40	1	(	(	PUNCT
cusj-7788	40	2	figure	figure	NOUN
cusj-7788	40	3	obtained	obtain	VERB
cusj-7788	40	4	and	and	CCONJ
cusj-7788	40	5	used	use	VERB
cusj-7788	40	6	with	with	ADP
cusj-7788	40	7	permission	permission	NOUN
cusj-7788	40	8	from	from	ADP
cusj-7788	40	9	openstax	openstax	ADJ
cusj-7788	40	10	microbiology	microbiology	NOUN
cusj-7788	40	11	textbook	textbook	NOUN
cusj-7788	40	12	[	[	X
cusj-7788	40	13	7	7	NUM
cusj-7788	40	14	]	]	PUNCT
cusj-7788	40	15	)	)	PUNCT
cusj-7788	40	16	(	(	PUNCT
cusj-7788	40	17	access	access	NOUN
cusj-7788	40	18	at	at	ADP
cusj-7788	40	19	https://openstax.org/books/microbiology/pages/1-introduction	https://openstax.org/books/microbiology/pages/1-introduction	NOUN
cusj-7788	40	20	)	)	PUNCT
cusj-7788	40	21	a	a	DET
cusj-7788	40	22	b	b	PROPN
cusj-7788	40	23	columbia	columbia	PROPN
cusj-7788	40	24	undergraduate	undergraduate	PROPN
cusj-7788	40	25	science	science	PROPN
cusj-7788	40	26	journal	journal	PROPN
cusj-7788	40	27	vol	vol	NOUN
cusj-7788	40	28	.	.	PROPN
cusj-7788	40	29	15	15	NUM
cusj-7788	40	30	,	,	PUNCT
cusj-7788	40	31	2021	2021	NUM
cusj-7788	40	32	obikili	obikili	NOUN
cusj-7788	40	33	57	57	NUM
cusj-7788	40	34	though	though	SCONJ
cusj-7788	40	35	they	they	PRON
cusj-7788	40	36	do	do	AUX
cusj-7788	40	37	not	not	PART
cusj-7788	40	38	have	have	VERB
cusj-7788	40	39	the	the	DET
cusj-7788	40	40	ability	ability	NOUN
cusj-7788	40	41	to	to	PART
cusj-7788	40	42	grow	grow	VERB
cusj-7788	40	43	on	on	ADP
cusj-7788	40	44	their	their	PRON
cusj-7788	40	45	own	own	ADJ
cusj-7788	40	46	,	,	PUNCT
cusj-7788	40	47	once	once	ADV
cusj-7788	40	48	inside	inside	ADP
cusj-7788	40	49	a	a	DET
cusj-7788	40	50	cell	cell	NOUN
cusj-7788	40	51	they	they	PRON
cusj-7788	40	52	use	use	VERB
cusj-7788	40	53	its	its	PRON
cusj-7788	40	54	machinery	machinery	NOUN
cusj-7788	40	55	to	to	PART
cusj-7788	40	56	grow	grow	VERB
cusj-7788	40	57	and	and	CCONJ
cusj-7788	40	58	multiply	multiply	VERB
cusj-7788	40	59	and	and	CCONJ
cusj-7788	40	60	have	have	VERB
cusj-7788	40	61	the	the	DET
cusj-7788	40	62	potential	potential	NOUN
cusj-7788	40	63	to	to	PART
cusj-7788	40	64	cause	cause	VERB
cusj-7788	40	65	diseases	disease	NOUN
cusj-7788	40	66	in	in	ADP
cusj-7788	40	67	the	the	DET
cusj-7788	40	68	host	host	NOUN
cusj-7788	40	69	organism	organism	NOUN
cusj-7788	40	70	.	.	PUNCT
cusj-7788	41	1	retroviruses	retrovirus	NOUN
cusj-7788	41	2	are	be	AUX
cusj-7788	41	3	viruses	virus	NOUN
cusj-7788	41	4	that	that	PRON
cusj-7788	41	5	use	use	VERB
cusj-7788	41	6	their	their	PRON
cusj-7788	41	7	viral	viral	ADJ
cusj-7788	41	8	rna	rna	NOUN
cusj-7788	41	9	-	-	PUNCT
cusj-7788	41	10	dependent	dependent	ADJ
cusj-7788	41	11	enzyme	enzyme	NOUN
cusj-7788	41	12	,	,	PUNCT
cusj-7788	41	13	reverse	reverse	ADJ
cusj-7788	41	14	transcriptase	transcriptase	NOUN
cusj-7788	41	15	,	,	PUNCT
cusj-7788	41	16	to	to	PART
cusj-7788	41	17	synthesize	synthesize	VERB
cusj-7788	41	18	viral	viral	ADJ
cusj-7788	41	19	dna	dna	NOUN
cusj-7788	41	20	in	in	ADP
cusj-7788	41	21	a	a	DET
cusj-7788	41	22	host	host	NOUN
cusj-7788	41	23	cell	cell	NOUN
cusj-7788	41	24	which	which	PRON
cusj-7788	41	25	is	be	AUX
cusj-7788	41	26	then	then	ADV
cusj-7788	41	27	inserted	insert	VERB
cusj-7788	41	28	into	into	ADP
cusj-7788	41	29	the	the	DET
cusj-7788	41	30	chromosomal	chromosomal	ADJ
cusj-7788	41	31	dna	dna	NOUN
cusj-7788	41	32	(	(	PUNCT
cusj-7788	41	33	fig	fig	NOUN
cusj-7788	41	34	.	.	PUNCT
cusj-7788	41	35	1b	1b	NUM
cusj-7788	41	36	)	)	PUNCT
cusj-7788	41	37	.	.	PUNCT
cusj-7788	42	1	hiv	hiv	PROPN
cusj-7788	42	2	is	be	AUX
cusj-7788	42	3	a	a	DET
cusj-7788	42	4	lentivirus	lentivirus	NOUN
cusj-7788	42	5	that	that	PRON
cusj-7788	42	6	infects	infect	VERB
cusj-7788	42	7	cd4	cd4	PROPN
cusj-7788	42	8	+	+	PROPN
cusj-7788	42	9	t	t	NOUN
cusj-7788	42	10	cells	cell	NOUN
cusj-7788	42	11	,	,	PUNCT
cusj-7788	42	12	macrophages	macrophage	NOUN
cusj-7788	42	13	,	,	PUNCT
cusj-7788	42	14	and	and	CCONJ
cusj-7788	42	15	dendritic	dendritic	ADJ
cusj-7788	42	16	cells	cell	NOUN
cusj-7788	42	17	in	in	ADP
cusj-7788	42	18	humans	human	NOUN
cusj-7788	42	19	[	[	X
cusj-7788	42	20	1	1	NUM
cusj-7788	42	21	]	]	PUNCT
cusj-7788	42	22	.	.	PUNCT
cusj-7788	43	1	the	the	DET
cusj-7788	43	2	process	process	NOUN
cusj-7788	43	3	of	of	ADP
cusj-7788	43	4	retrovirus	retrovirus	NOUN
cusj-7788	43	5	infection	infection	NOUN
cusj-7788	43	6	is	be	AUX
cusj-7788	43	7	shown	show	VERB
cusj-7788	43	8	in	in	ADP
cusj-7788	43	9	fig	fig	NOUN
cusj-7788	43	10	.	.	PUNCT
cusj-7788	44	1	2	2	X
cusj-7788	44	2	.	.	X
cusj-7788	45	1	once	once	ADV
cusj-7788	45	2	a	a	DET
cusj-7788	45	3	retrovirus	retrovirus	NOUN
cusj-7788	45	4	encounters	encounter	VERB
cusj-7788	45	5	a	a	DET
cusj-7788	45	6	host	host	NOUN
cusj-7788	45	7	cell	cell	NOUN
cusj-7788	45	8	,	,	PUNCT
cusj-7788	45	9	it	it	PRON
cusj-7788	45	10	binds	bind	VERB
cusj-7788	45	11	to	to	ADP
cusj-7788	45	12	a	a	DET
cusj-7788	45	13	cell	cell	NOUN
cusj-7788	45	14	surface	surface	NOUN
cusj-7788	45	15	receptor	receptor	NOUN
cusj-7788	45	16	,	,	PUNCT
cusj-7788	45	17	hence	hence	ADV
cusj-7788	45	18	enabling	enable	VERB
cusj-7788	45	19	its	its	PRON
cusj-7788	45	20	fusion	fusion	NOUN
cusj-7788	45	21	with	with	ADP
cusj-7788	45	22	the	the	DET
cusj-7788	45	23	cell	cell	NOUN
cusj-7788	45	24	.	.	PUNCT
cusj-7788	46	1	after	after	SCONJ
cusj-7788	46	2	it	it	PRON
cusj-7788	46	3	fuses	fuse	VERB
cusj-7788	46	4	with	with	ADP
cusj-7788	46	5	the	the	DET
cusj-7788	46	6	cell	cell	NOUN
cusj-7788	46	7	,	,	PUNCT
cusj-7788	46	8	it	it	PRON
cusj-7788	46	9	uncoats	uncoat	VERB
cusj-7788	46	10	its	its	PRON
cusj-7788	46	11	rna	rna	NOUN
cusj-7788	46	12	genome	genome	NOUN
cusj-7788	46	13	and	and	CCONJ
cusj-7788	46	14	enzymes	enzyme	NOUN
cusj-7788	46	15	,	,	PUNCT
cusj-7788	46	16	such	such	ADJ
cusj-7788	46	17	as	as	ADP
cusj-7788	46	18	reverse	reverse	ADJ
cusj-7788	46	19	transcriptase	transcriptase	NOUN
cusj-7788	46	20	(	(	PUNCT
cusj-7788	46	21	rt	rt	PROPN
cusj-7788	46	22	)	)	PUNCT
cusj-7788	46	23	,	,	PUNCT
cusj-7788	46	24	which	which	PRON
cusj-7788	46	25	then	then	ADV
cusj-7788	46	26	synthesize	synthesize	VERB
cusj-7788	46	27	a	a	DET
cusj-7788	46	28	new	new	ADJ
cusj-7788	46	29	copy	copy	NOUN
cusj-7788	46	30	of	of	ADP
cusj-7788	46	31	the	the	DET
cusj-7788	46	32	viral	viral	ADJ
cusj-7788	46	33	dna	dna	NOUN
cusj-7788	46	34	from	from	ADP
cusj-7788	46	35	the	the	DET
cusj-7788	46	36	rna	rna	NOUN
cusj-7788	46	37	template	template	NOUN
cusj-7788	46	38	.	.	PUNCT
cusj-7788	47	1	then	then	ADV
cusj-7788	47	2	the	the	DET
cusj-7788	47	3	viral	viral	ADJ
cusj-7788	47	4	dna	dna	PROPN
cusj-7788	47	5	enters	enter	VERB
cusj-7788	47	6	the	the	DET
cusj-7788	47	7	nucleus	nucleus	NOUN
cusj-7788	47	8	and	and	CCONJ
cusj-7788	47	9	the	the	DET
cusj-7788	47	10	viral	viral	ADJ
cusj-7788	47	11	enzyme	enzyme	NOUN
cusj-7788	47	12	integrase	integrase	NOUN
cusj-7788	47	13	,	,	PUNCT
cusj-7788	47	14	along	along	ADP
cusj-7788	47	15	with	with	ADP
cusj-7788	47	16	several	several	ADJ
cusj-7788	47	17	host	host	NOUN
cusj-7788	47	18	proteins	protein	NOUN
cusj-7788	47	19	,	,	PUNCT
cusj-7788	47	20	splices	splice	VERB
cusj-7788	47	21	the	the	DET
cusj-7788	47	22	viral	viral	ADJ
cusj-7788	47	23	dna	dna	NOUN
cusj-7788	47	24	into	into	ADP
cusj-7788	47	25	the	the	DET
cusj-7788	47	26	cell	cell	NOUN
cusj-7788	47	27	’s	’s	PART
cusj-7788	47	28	genome	genome	NOUN
cusj-7788	47	29	.	.	PUNCT
cusj-7788	48	1	cellular	cellular	ADJ
cusj-7788	48	2	rna	rna	NOUN
cusj-7788	48	3	polymerase	polymerase	NOUN
cusj-7788	48	4	is	be	AUX
cusj-7788	48	5	then	then	ADV
cusj-7788	48	6	used	use	VERB
cusj-7788	48	7	to	to	PART
cusj-7788	48	8	transcribe	transcribe	VERB
cusj-7788	48	9	the	the	DET
cusj-7788	48	10	viral	viral	ADJ
cusj-7788	48	11	dna	dna	NOUN
cusj-7788	48	12	into	into	ADP
cusj-7788	48	13	mrna	mrna	PROPN
cusj-7788	48	14	which	which	PRON
cusj-7788	48	15	is	be	AUX
cusj-7788	48	16	then	then	ADV
cusj-7788	48	17	translated	translate	VERB
cusj-7788	48	18	into	into	ADP
cusj-7788	48	19	viral	viral	ADJ
cusj-7788	48	20	protein	protein	NOUN
cusj-7788	48	21	.	.	PUNCT
cusj-7788	49	1	the	the	DET
cusj-7788	49	2	new	new	ADJ
cusj-7788	49	3	virions	virion	NOUN
cusj-7788	49	4	made	make	VERB
cusj-7788	49	5	are	be	AUX
cusj-7788	49	6	assembled	assemble	VERB
cusj-7788	49	7	at	at	ADP
cusj-7788	49	8	the	the	DET
cusj-7788	49	9	host	host	NOUN
cusj-7788	49	10	membrane	membrane	NOUN
cusj-7788	49	11	and	and	CCONJ
cusj-7788	49	12	bud	bud	NOUN
cusj-7788	49	13	off	off	ADP
cusj-7788	49	14	from	from	ADP
cusj-7788	49	15	the	the	DET
cusj-7788	49	16	cell	cell	NOUN
cusj-7788	49	17	membrane	membrane	NOUN
cusj-7788	49	18	.	.	PUNCT
cusj-7788	50	1	the	the	DET
cusj-7788	50	2	final	final	ADJ
cusj-7788	50	3	stage	stage	NOUN
cusj-7788	50	4	consists	consist	VERB
cusj-7788	50	5	of	of	ADP
cusj-7788	50	6	the	the	DET
cusj-7788	50	7	retrovirus	retrovirus	NOUN
cusj-7788	50	8	protease	protease	NOUN
cusj-7788	50	9	enzyme	enzyme	NOUN
cusj-7788	50	10	cleaving	cleave	VERB
cusj-7788	50	11	the	the	DET
cusj-7788	50	12	precursor	precursor	NOUN
cusj-7788	50	13	proteins	protein	NOUN
cusj-7788	50	14	into	into	ADP
cusj-7788	50	15	mature	mature	ADJ
cusj-7788	50	16	viral	viral	ADJ
cusj-7788	50	17	proteins	protein	NOUN
cusj-7788	50	18	leading	lead	VERB
cusj-7788	50	19	to	to	ADP
cusj-7788	50	20	the	the	DET
cusj-7788	50	21	maturation	maturation	NOUN
cusj-7788	50	22	of	of	ADP
cusj-7788	50	23	the	the	DET
cusj-7788	50	24	virus	virus	NOUN
cusj-7788	50	25	and	and	CCONJ
cusj-7788	50	26	the	the	DET
cusj-7788	50	27	start	start	NOUN
cusj-7788	50	28	of	of	ADP
cusj-7788	50	29	a	a	DET
cusj-7788	50	30	new	new	ADJ
cusj-7788	50	31	cycle	cycle	NOUN
cusj-7788	50	32	[	[	X
cusj-7788	50	33	8	8	NUM
cusj-7788	50	34	]	]	PUNCT
cusj-7788	50	35	.	.	PUNCT
cusj-7788	51	1	retroviral	retroviral	ADJ
cusj-7788	51	2	evolution	evolution	NOUN
cusj-7788	51	3	the	the	DET
cusj-7788	51	4	cytidine	cytidine	NOUN
cusj-7788	51	5	deaminase	deaminase	NOUN
cusj-7788	51	6	activity	activity	NOUN
cusj-7788	51	7	of	of	ADP
cusj-7788	51	8	a3	a3	NOUN
cusj-7788	51	9	proteins	protein	NOUN
cusj-7788	51	10	may	may	AUX
cusj-7788	51	11	also	also	ADV
cusj-7788	51	12	lead	lead	VERB
cusj-7788	51	13	to	to	ADP
cusj-7788	51	14	retroviral	retroviral	ADJ
cusj-7788	51	15	evolution	evolution	NOUN
cusj-7788	51	16	,	,	PUNCT
cusj-7788	51	17	where	where	SCONJ
cusj-7788	51	18	the	the	DET
cusj-7788	51	19	virus	virus	NOUN
cusj-7788	51	20	gains	gain	VERB
cusj-7788	51	21	beneficial	beneficial	ADJ
cusj-7788	51	22	mutations	mutation	NOUN
cusj-7788	51	23	that	that	PRON
cusj-7788	51	24	help	help	VERB
cusj-7788	51	25	the	the	DET
cusj-7788	51	26	virus	virus	NOUN
cusj-7788	51	27	to	to	PART
cusj-7788	51	28	counteract	counteract	VERB
cusj-7788	51	29	a3	a3	NOUN
cusj-7788	51	30	antiviral	antiviral	ADJ
cusj-7788	51	31	activity	activity	NOUN
cusj-7788	51	32	[	[	X
cusj-7788	51	33	5	5	NUM
cusj-7788	51	34	,	,	PUNCT
cusj-7788	51	35	6	6	NUM
cusj-7788	51	36	]	]	PUNCT
cusj-7788	51	37	.	.	PUNCT
cusj-7788	52	1	a3	a3	PROPN
cusj-7788	52	2	g	g	PROPN
cusj-7788	52	3	has	have	AUX
cusj-7788	52	4	been	be	AUX
cusj-7788	52	5	shown	show	VERB
cusj-7788	52	6	to	to	PART
cusj-7788	52	7	preferentially	preferentially	ADV
cusj-7788	52	8	deaminate	deaminate	VERB
cusj-7788	52	9	cc	cc	ADP
cusj-7788	52	10	motifs	motif	NOUN
cusj-7788	52	11	,	,	PUNCT
cusj-7788	52	12	resulting	result	VERB
cusj-7788	52	13	in	in	ADP
cusj-7788	52	14	ag	ag	PROPN
cusj-7788	52	15	motifs	motif	NOUN
cusj-7788	52	16	in	in	ADP
cusj-7788	52	17	the	the	DET
cusj-7788	52	18	coding	code	VERB
cusj-7788	52	19	strand	strand	NOUN
cusj-7788	52	20	,	,	PUNCT
cusj-7788	52	21	whereas	whereas	SCONJ
cusj-7788	52	22	the	the	DET
cusj-7788	52	23	other	other	ADJ
cusj-7788	52	24	a3	a3	NOUN
cusj-7788	52	25	proteins	protein	NOUN
cusj-7788	52	26	have	have	AUX
cusj-7788	52	27	been	be	AUX
cusj-7788	52	28	shown	show	VERB
cusj-7788	52	29	to	to	PART
cusj-7788	52	30	preferentially	preferentially	ADV
cusj-7788	52	31	deaminate	deaminate	VERB
cusj-7788	52	32	tc	tc	NUM
cusj-7788	52	33	motifs	motif	NOUN
cusj-7788	52	34	,	,	PUNCT
cusj-7788	52	35	resulting	result	VERB
cusj-7788	52	36	in	in	ADP
cusj-7788	52	37	aa	aa	ADJ
cusj-7788	52	38	motifs	motif	NOUN
cusj-7788	53	1	[	[	X
cusj-7788	53	2	5	5	NUM
cusj-7788	53	3	,	,	PUNCT
cusj-7788	53	4	6	6	NUM
cusj-7788	53	5	]	]	PUNCT
cusj-7788	53	6	.	.	PUNCT
cusj-7788	54	1	however	however	ADV
cusj-7788	54	2	,	,	PUNCT
cusj-7788	54	3	hiv-1	hiv-1	PUNCT
cusj-7788	54	4	encodes	encode	VERB
cusj-7788	54	5	a	a	DET
cusj-7788	54	6	protein	protein	NOUN
cusj-7788	54	7	the	the	DET
cusj-7788	54	8	viral	viral	ADJ
cusj-7788	54	9	infectivity	infectivity	NOUN
cusj-7788	54	10	factor	factor	NOUN
cusj-7788	54	11	(	(	PUNCT
cusj-7788	54	12	vif	vif	PROPN
cusj-7788	54	13	)	)	PUNCT
cusj-7788	54	14	,	,	PUNCT
cusj-7788	54	15	which	which	PRON
cusj-7788	54	16	leads	lead	VERB
cusj-7788	54	17	to	to	ADP
cusj-7788	54	18	the	the	DET
cusj-7788	54	19	degradation	degradation	NOUN
cusj-7788	54	20	of	of	ADP
cusj-7788	54	21	a3	a3	NOUN
cusj-7788	54	22	proteins	protein	NOUN
cusj-7788	54	23	in	in	ADP
cusj-7788	54	24	virus	virus	NOUN
cusj-7788	54	25	-	-	PUNCT
cusj-7788	54	26	producing	produce	VERB
cusj-7788	54	27	cells	cell	NOUN
cusj-7788	54	28	[	[	X
cusj-7788	54	29	5	5	NUM
cusj-7788	54	30	]	]	PUNCT
cusj-7788	54	31	.	.	PUNCT
cusj-7788	55	1	vif	vif	NOUN
cusj-7788	55	2	has	have	VERB
cusj-7788	55	3	two	two	NUM
cusj-7788	55	4	motifs	motif	NOUN
cusj-7788	55	5	that	that	PRON
cusj-7788	55	6	bind	bind	VERB
cusj-7788	55	7	to	to	PART
cusj-7788	55	8	a3	a3	VERB
cusj-7788	55	9	proteins	protein	NOUN
cusj-7788	55	10	:	:	PUNCT
cusj-7788	55	11	drmr	drmr	NOUN
cusj-7788	55	12	which	which	PRON
cusj-7788	55	13	binds	bind	VERB
cusj-7788	55	14	to	to	PART
cusj-7788	55	15	and	and	CCONJ
cusj-7788	55	16	degrades	degrade	VERB
cusj-7788	55	17	a3f	a3f	PROPN
cusj-7788	55	18	and	and	CCONJ
cusj-7788	55	19	a3d	a3d	NOUN
cusj-7788	55	20	,	,	PUNCT
cusj-7788	55	21	and	and	CCONJ
cusj-7788	55	22	the	the	DET
cusj-7788	55	23	other	other	ADJ
cusj-7788	55	24	motif	motif	NOUN
cusj-7788	55	25	,	,	PUNCT
cusj-7788	55	26	yrhhy	yrhhy	PROPN
cusj-7788	55	27	,	,	PUNCT
cusj-7788	55	28	which	which	PRON
cusj-7788	55	29	binds	bind	VERB
cusj-7788	55	30	to	to	PART
cusj-7788	55	31	a3	a3	VERB
cusj-7788	55	32	g	g	NOUN
cusj-7788	55	33	,	,	PUNCT
cusj-7788	55	34	leading	lead	VERB
cusj-7788	55	35	to	to	ADP
cusj-7788	55	36	its	its	PRON
cusj-7788	55	37	degradation	degradation	NOUN
cusj-7788	55	38	[	[	X
cusj-7788	55	39	5	5	NUM
cusj-7788	55	40	]	]	PUNCT
cusj-7788	55	41	.	.	PUNCT
cusj-7788	56	1	fig	fig	NOUN
cusj-7788	56	2	.	.	PUNCT
cusj-7788	57	1	3	3	NUM
cusj-7788	57	2	shows	show	VERB
cusj-7788	57	3	the	the	DET
cusj-7788	57	4	structure	structure	NOUN
cusj-7788	57	5	of	of	ADP
cusj-7788	57	6	the	the	DET
cusj-7788	57	7	vif	vif	NOUN
cusj-7788	57	8	complex	complex	NOUN
cusj-7788	58	1	[	[	X
cusj-7788	58	2	5	5	NUM
cusj-7788	58	3	]	]	PUNCT
cusj-7788	58	4	.	.	PUNCT
cusj-7788	59	1	when	when	SCONJ
cusj-7788	59	2	vif	vif	PROPN
cusj-7788	59	3	binds	bind	VERB
cusj-7788	59	4	to	to	PART
cusj-7788	59	5	a3	a3	VERB
cusj-7788	59	6	,	,	PUNCT
cusj-7788	59	7	it	it	PRON
cusj-7788	59	8	prevents	prevent	VERB
cusj-7788	59	9	it	it	PRON
cusj-7788	59	10	from	from	ADP
cusj-7788	59	11	entering	enter	VERB
cusj-7788	59	12	the	the	DET
cusj-7788	59	13	budding	bud	VERB
cusj-7788	59	14	virion	virion	NOUN
cusj-7788	59	15	by	by	ADP
cusj-7788	59	16	targeting	target	VERB
cusj-7788	59	17	it	it	PRON
cusj-7788	59	18	for	for	ADP
cusj-7788	59	19	degradation	degradation	NOUN
cusj-7788	59	20	.	.	PUNCT
cusj-7788	60	1	it	it	PRON
cusj-7788	60	2	does	do	VERB
cusj-7788	60	3	this	this	PRON
cusj-7788	60	4	by	by	ADP
cusj-7788	60	5	binding	bind	VERB
cusj-7788	60	6	to	to	ADP
cusj-7788	60	7	cbfb	cbfb	NOUN
cusj-7788	60	8	co	co	NOUN
cusj-7788	60	9	-	-	NOUN
cusj-7788	60	10	factor	factor	NOUN
cusj-7788	60	11	and	and	CCONJ
cusj-7788	60	12	cullin	cullin	PROPN
cusj-7788	60	13	5	5	NUM
cusj-7788	60	14	e3	e3	NOUN
cusj-7788	60	15	–	–	PUNCT
cusj-7788	60	16	ubiquitin	ubiquitin	ADJ
cusj-7788	60	17	ligase	ligase	NOUN
cusj-7788	60	18	(	(	PUNCT
cusj-7788	60	19	elob	elob	NOUN
cusj-7788	60	20	-	-	PUNCT
cusj-7788	60	21	eloc	eloc	NOUN
cusj-7788	60	22	-	-	NOUN
cusj-7788	60	23	cul5	cul5	PROPN
cusj-7788	60	24	)	)	PUNCT
cusj-7788	60	25	,	,	PUNCT
cusj-7788	60	26	via	via	ADP
cusj-7788	60	27	the	the	DET
cusj-7788	60	28	sites	site	NOUN
cusj-7788	60	29	diagrammed	diagram	VERB
cusj-7788	60	30	in	in	ADP
cusj-7788	60	31	fig	fig	NOUN
cusj-7788	60	32	.	.	PUNCT
cusj-7788	61	1	3b	3b	NUM
cusj-7788	61	2	,	,	PUNCT
cusj-7788	61	3	which	which	PRON
cusj-7788	61	4	then	then	ADV
cusj-7788	61	5	targets	target	VERB
cusj-7788	61	6	the	the	DET
cusj-7788	61	7	a3	a3	NOUN
cusj-7788	61	8	protein	protein	NOUN
cusj-7788	61	9	for	for	ADP
cusj-7788	61	10	proteasomal	proteasomal	ADJ
cusj-7788	61	11	degradation	degradation	NOUN
cusj-7788	62	1	[	[	X
cusj-7788	62	2	5	5	NUM
cusj-7788	62	3	]	]	PUNCT
cusj-7788	62	4	.	.	PUNCT
cusj-7788	63	1	figure	figure	VERB
cusj-7788	63	2	3	3	NUM
cusj-7788	63	3	:	:	PUNCT
cusj-7788	63	4	the	the	DET
cusj-7788	63	5	structure	structure	NOUN
cusj-7788	63	6	of	of	ADP
cusj-7788	63	7	vif	vif	NOUN
cusj-7788	63	8	(	(	PUNCT
cusj-7788	63	9	a	a	NOUN
cusj-7788	63	10	)	)	PUNCT
cusj-7788	63	11	shows	show	VERB
cusj-7788	63	12	the	the	DET
cusj-7788	63	13	two	two	NUM
cusj-7788	63	14	vif	vif	NOUN
cusj-7788	63	15	motifs	motif	NOUN
cusj-7788	63	16	that	that	PRON
cusj-7788	63	17	bind	bind	VERB
cusj-7788	63	18	to	to	PART
cusj-7788	63	19	a3	a3	VERB
cusj-7788	63	20	proteins	protein	NOUN
cusj-7788	63	21	.	.	PUNCT
cusj-7788	64	1	drmr	drmr	NOUN
cusj-7788	64	2	(	(	PUNCT
cusj-7788	64	3	red	red	PROPN
cusj-7788	64	4	)	)	PUNCT
cusj-7788	64	5	binds	bind	VERB
cusj-7788	64	6	to	to	ADP
cusj-7788	64	7	a3d	a3d	PROPN
cusj-7788	64	8	and	and	CCONJ
cusj-7788	64	9	a3f	a3f	PROPN
cusj-7788	64	10	,	,	PUNCT
cusj-7788	64	11	whereas	whereas	SCONJ
cusj-7788	64	12	yrhhy	yrhhy	PROPN
cusj-7788	64	13	(	(	PUNCT
cusj-7788	64	14	blue	blue	ADJ
cusj-7788	64	15	)	)	PUNCT
cusj-7788	64	16	binds	bind	VERB
cusj-7788	64	17	to	to	PART
cusj-7788	64	18	a3	a3	VERB
cusj-7788	64	19	g	g	PROPN
cusj-7788	64	20	(	(	PUNCT
cusj-7788	64	21	b	b	NOUN
cusj-7788	64	22	)	)	PUNCT
cusj-7788	64	23	shows	show	VERB
cusj-7788	64	24	the	the	DET
cusj-7788	64	25	vif	vif	NOUN
cusj-7788	64	26	complex	complex	NOUN
cusj-7788	64	27	.	.	PUNCT
cusj-7788	65	1	the	the	DET
cusj-7788	65	2	blue	blue	ADJ
cusj-7788	65	3	and	and	CCONJ
cusj-7788	65	4	red	red	ADJ
cusj-7788	65	5	correspond	correspond	NOUN
cusj-7788	65	6	to	to	ADP
cusj-7788	65	7	the	the	DET
cusj-7788	65	8	vif	vif	NOUN
cusj-7788	65	9	binding	bind	VERB
cusj-7788	65	10	motifs	motif	NOUN
cusj-7788	65	11	in	in	ADP
cusj-7788	65	12	a	a	PRON
cusj-7788	65	13	where	where	SCONJ
cusj-7788	65	14	vif	vif	NOUN
cusj-7788	65	15	binds	bind	VERB
cusj-7788	65	16	to	to	ADP
cusj-7788	65	17	a3d	a3d	PROPN
cusj-7788	65	18	,	,	PUNCT
cusj-7788	65	19	a3f	a3f	ADJ
cusj-7788	65	20	and	and	CCONJ
cusj-7788	65	21	a3	a3	PROPN
cusj-7788	65	22	g	g	NOUN
cusj-7788	65	23	,	,	PUNCT
cusj-7788	65	24	respectively	respectively	ADV
cusj-7788	65	25	.	.	PUNCT
cusj-7788	66	1	the	the	DET
cusj-7788	66	2	yellow	yellow	ADJ
cusj-7788	66	3	,	,	PUNCT
cusj-7788	66	4	cyan	cyan	ADJ
cusj-7788	66	5	and	and	CCONJ
cusj-7788	66	6	pink	pink	ADJ
cusj-7788	66	7	colors	color	NOUN
cusj-7788	66	8	represent	represent	VERB
cusj-7788	66	9	the	the	DET
cusj-7788	66	10	vif	vif	NOUN
cusj-7788	66	11	protein	protein	NOUN
cusj-7788	66	12	,	,	PUNCT
cusj-7788	66	13	cbfb	cbfb	NOUN
cusj-7788	66	14	co	co	NOUN
cusj-7788	66	15	-	-	NOUN
cusj-7788	66	16	factor	factor	NOUN
cusj-7788	66	17	and	and	CCONJ
cusj-7788	66	18	cul5	cul5	PROPN
cusj-7788	66	19	ligase	ligase	VERB
cusj-7788	66	20	respectively	respectively	ADV
cusj-7788	66	21	(	(	PUNCT
cusj-7788	66	22	fig	fig	NOUN
cusj-7788	66	23	.	.	PUNCT
cusj-7788	66	24	obtained	obtain	VERB
cusj-7788	66	25	from	from	ADP
cusj-7788	66	26	sato	sato	PROPN
cusj-7788	67	1	k.	k.	PROPN
cusj-7788	67	2	et	et	PROPN
cusj-7788	67	3	al	al	PROPN
cusj-7788	67	4	.	.	PROPN
cusj-7788	67	5	2014	2014	NUM
cusj-7788	67	6	,	,	PUNCT
cusj-7788	67	7	with	with	ADP
cusj-7788	67	8	permission	permission	NOUN
cusj-7788	67	9	to	to	PART
cusj-7788	67	10	reprint	reprint	VERB
cusj-7788	67	11	from	from	ADP
cusj-7788	67	12	plos	plos	PROPN
cusj-7788	67	13	pathogens	pathogen	NOUN
cusj-7788	67	14	)	)	PUNCT
cusj-7788	67	15	.	.	PUNCT
cusj-7788	68	1	viral	viral	ADJ
cusj-7788	68	2	evolution	evolution	NOUN
cusj-7788	68	3	can	can	AUX
cusj-7788	68	4	occur	occur	VERB
cusj-7788	68	5	when	when	SCONJ
cusj-7788	68	6	there	there	PRON
cusj-7788	68	7	are	be	VERB
cusj-7788	68	8	defective	defective	ADJ
cusj-7788	68	9	(	(	PUNCT
cusj-7788	68	10	mutant	mutant	ADJ
cusj-7788	68	11	)	)	PUNCT
cusj-7788	68	12	vif	vif	NOUN
cusj-7788	68	13	proteins	protein	NOUN
cusj-7788	68	14	.	.	PUNCT
cusj-7788	69	1	the	the	DET
cusj-7788	69	2	defective	defective	ADJ
cusj-7788	69	3	proteins	protein	NOUN
cusj-7788	69	4	do	do	AUX
cusj-7788	69	5	not	not	PART
cusj-7788	69	6	cause	cause	VERB
cusj-7788	69	7	complete	complete	ADJ
cusj-7788	69	8	a3	a3	NOUN
cusj-7788	69	9	degradation	degradation	NOUN
cusj-7788	69	10	and	and	CCONJ
cusj-7788	69	11	therefore	therefore	ADV
cusj-7788	69	12	allow	allow	VERB
cusj-7788	69	13	some	some	DET
cusj-7788	69	14	a3	a3	NOUN
cusj-7788	69	15	proteins	protein	NOUN
cusj-7788	69	16	to	to	PART
cusj-7788	69	17	enter	enter	VERB
cusj-7788	69	18	the	the	DET
cusj-7788	69	19	virion	virion	NOUN
cusj-7788	69	20	,	,	PUNCT
cusj-7788	69	21	resulting	result	VERB
cusj-7788	69	22	in	in	ADP
cusj-7788	69	23	mutations	mutation	NOUN
cusj-7788	69	24	in	in	ADP
cusj-7788	69	25	the	the	DET
cusj-7788	69	26	viral	viral	ADJ
cusj-7788	69	27	genome	genome	NOUN
cusj-7788	69	28	.	.	PUNCT
cusj-7788	70	1	since	since	SCONJ
cusj-7788	70	2	a3	a3	NOUN
cusj-7788	70	3	g	g	PROPN
cusj-7788	70	4	prefers	prefer	VERB
cusj-7788	70	5	to	to	PART
cusj-7788	70	6	deaminate	deaminate	VERB
cusj-7788	70	7	tggg	tggg	NOUN
cusj-7788	70	8	–	–	PUNCT
cusj-7788	70	9	tagg	tagg	PROPN
cusj-7788	70	10	motifs	motif	VERB
cusj-7788	70	11	,	,	PUNCT
cusj-7788	70	12	it	it	PRON
cusj-7788	70	13	often	often	ADV
cusj-7788	70	14	converts	convert	VERB
cusj-7788	70	15	the	the	DET
cusj-7788	70	16	codon	codon	NOUN
cusj-7788	70	17	encoding	encoding	NOUN
cusj-7788	70	18	for	for	ADP
cusj-7788	70	19	the	the	DET
cusj-7788	70	20	amino	amino	NOUN
cusj-7788	70	21	acid	acid	NOUN
cusj-7788	70	22	tryptophan	tryptophan	NOUN
cusj-7788	70	23	(	(	PUNCT
cusj-7788	70	24	tgg	tgg	PROPN
cusj-7788	70	25	)	)	PUNCT
cusj-7788	70	26	into	into	ADP
cusj-7788	70	27	a	a	DET
cusj-7788	70	28	stop	stop	NOUN
cusj-7788	70	29	codon	codon	NOUN
cusj-7788	70	30	(	(	PUNCT
cusj-7788	70	31	tag	tag	NOUN
cusj-7788	70	32	)	)	PUNCT
cusj-7788	70	33	,	,	PUNCT
cusj-7788	70	34	which	which	PRON
cusj-7788	70	35	renders	render	VERB
cusj-7788	70	36	the	the	DET
cusj-7788	70	37	virus	virus	NOUN
cusj-7788	70	38	defective	defective	ADJ
cusj-7788	70	39	and	and	CCONJ
cusj-7788	70	40	unable	unable	ADJ
cusj-7788	70	41	to	to	PART
cusj-7788	70	42	synthesize	synthesize	VERB
cusj-7788	70	43	its	its	PRON
cusj-7788	70	44	proteins	protein	NOUN
cusj-7788	70	45	.	.	PUNCT
cusj-7788	71	1	this	this	PRON
cusj-7788	71	2	prevents	prevent	VERB
cusj-7788	71	3	it	it	PRON
cusj-7788	71	4	from	from	ADP
cusj-7788	71	5	`	`	PUNCT
cusj-7788	71	6	assembling	assemble	VERB
cusj-7788	71	7	at	at	ADP
cusj-7788	71	8	the	the	DET
cusj-7788	71	9	host	host	NOUN
cusj-7788	71	10	cell	cell	NOUN
cusj-7788	71	11	’s	’s	PART
cusj-7788	71	12	membrane	membrane	NOUN
cusj-7788	71	13	and	and	CCONJ
cusj-7788	71	14	infecting	infect	VERB
cusj-7788	71	15	other	other	ADJ
cusj-7788	71	16	cells	cell	NOUN
cusj-7788	71	17	.	.	PUNCT
cusj-7788	72	1	sato	sato	PROPN
cusj-7788	72	2	et	et	PROPN
cusj-7788	72	3	al	al	PROPN
cusj-7788	72	4	.	.	PROPN
cusj-7788	72	5	found	find	VERB
cusj-7788	72	6	that	that	SCONJ
cusj-7788	72	7	a3	a3	NOUN
cusj-7788	72	8	proteins	protein	NOUN
cusj-7788	72	9	lead	lead	VERB
cusj-7788	72	10	to	to	ADP
cusj-7788	72	11	mutations	mutation	NOUN
cusj-7788	72	12	in	in	ADP
cusj-7788	72	13	the	the	DET
cusj-7788	72	14	env	env	NOUN
cusj-7788	72	15	region	region	NOUN
cusj-7788	72	16	of	of	ADP
cusj-7788	72	17	the	the	DET
cusj-7788	72	18	hiv-1	hiv-1	ADJ
cusj-7788	72	19	genome	genome	NOUN
cusj-7788	72	20	,	,	PUNCT
cusj-7788	72	21	which	which	PRON
cusj-7788	72	22	codes	code	VERB
cusj-7788	72	23	for	for	ADP
cusj-7788	72	24	the	the	DET
cusj-7788	72	25	viral	viral	ADJ
cusj-7788	72	26	glycoprotein	glycoprotein	NOUN
cusj-7788	73	1	[	[	X
cusj-7788	73	2	5	5	NUM
cusj-7788	73	3	]	]	PUNCT
cusj-7788	73	4	.	.	PUNCT
cusj-7788	74	1	this	this	DET
cusj-7788	74	2	protein	protein	NOUN
cusj-7788	74	3	is	be	AUX
cusj-7788	74	4	important	important	ADJ
cusj-7788	74	5	for	for	ADP
cusj-7788	74	6	enabling	enable	VERB
cusj-7788	74	7	the	the	DET
cusj-7788	74	8	virus	virus	NOUN
cusj-7788	74	9	to	to	PART
cusj-7788	74	10	bind	bind	VERB
cusj-7788	74	11	to	to	ADP
cusj-7788	74	12	cellular	cellular	ADJ
cusj-7788	74	13	receptors	receptor	NOUN
cusj-7788	74	14	and	and	CCONJ
cusj-7788	74	15	fuse	fuse	NOUN
cusj-7788	74	16	with	with	ADP
cusj-7788	74	17	the	the	DET
cusj-7788	74	18	host	host	NOUN
cusj-7788	74	19	cell	cell	NOUN
cusj-7788	74	20	’s	’s	PART
cusj-7788	74	21	membrane	membrane	NOUN
cusj-7788	74	22	.	.	PUNCT
cusj-7788	75	1	mutations	mutation	NOUN
cusj-7788	75	2	caused	cause	VERB
cusj-7788	75	3	by	by	ADP
cusj-7788	75	4	columbia	columbia	PROPN
cusj-7788	75	5	undergraduate	undergraduate	PROPN
cusj-7788	75	6	science	science	PROPN
cusj-7788	75	7	journal	journal	PROPN
cusj-7788	75	8	vol	vol	NOUN
cusj-7788	75	9	.	.	PROPN
cusj-7788	75	10	15	15	NUM
cusj-7788	75	11	,	,	PUNCT
cusj-7788	75	12	2021	2021	NUM
cusj-7788	75	13	obikili	obikili	NOUN
cusj-7788	75	14	.	.	PUNCT
cusj-7788	76	1	58	58	NUM
cusj-7788	76	2	a3	a3	NOUN
cusj-7788	76	3	proteins	protein	NOUN
cusj-7788	76	4	inhibit	inhibit	VERB
cusj-7788	76	5	the	the	DET
cusj-7788	76	6	virus	virus	NOUN
cusj-7788	76	7	from	from	ADP
cusj-7788	76	8	synthesizing	synthesize	VERB
cusj-7788	76	9	its	its	PRON
cusj-7788	76	10	glycoprotein	glycoprotein	NOUN
cusj-7788	76	11	,	,	PUNCT
cusj-7788	76	12	which	which	PRON
cusj-7788	76	13	in	in	ADP
cusj-7788	76	14	turn	turn	NOUN
cusj-7788	76	15	prevents	prevent	VERB
cusj-7788	76	16	it	it	PRON
cusj-7788	76	17	from	from	ADP
cusj-7788	76	18	infecting	infect	VERB
cusj-7788	76	19	the	the	DET
cusj-7788	76	20	cell	cell	NOUN
cusj-7788	76	21	.	.	PUNCT
cusj-7788	77	1	these	these	DET
cusj-7788	77	2	defective	defective	ADJ
cusj-7788	77	3	viruses	virus	NOUN
cusj-7788	77	4	may	may	AUX
cusj-7788	77	5	later	later	ADV
cusj-7788	77	6	get	get	AUX
cusj-7788	77	7	degraded	degrade	VERB
cusj-7788	77	8	.	.	PUNCT
cusj-7788	78	1	occasionally	occasionally	ADV
cusj-7788	78	2	,	,	PUNCT
cusj-7788	78	3	the	the	DET
cusj-7788	78	4	resulting	result	VERB
cusj-7788	78	5	g	g	NOUN
cusj-7788	78	6	-	-	PUNCT
cusj-7788	78	7	to	to	ADP
cusj-7788	78	8	-	-	PUNCT
cusj-7788	78	9	a	a	DET
cusj-7788	78	10	mutations	mutation	NOUN
cusj-7788	78	11	may	may	AUX
cusj-7788	78	12	also	also	ADV
cusj-7788	78	13	be	be	AUX
cusj-7788	78	14	sub	sub	ADJ
cusj-7788	78	15	-	-	ADJ
cusj-7788	78	16	lethal	lethal	ADJ
cusj-7788	78	17	(	(	PUNCT
cusj-7788	78	18	depending	depend	VERB
cusj-7788	78	19	on	on	ADP
cusj-7788	78	20	the	the	DET
cusj-7788	78	21	levels	level	NOUN
cusj-7788	78	22	of	of	ADP
cusj-7788	78	23	a3	a3	NOUN
cusj-7788	78	24	g	g	PROPN
cusj-7788	78	25	present	present	NOUN
cusj-7788	78	26	in	in	ADP
cusj-7788	78	27	the	the	DET
cusj-7788	78	28	cell	cell	NOUN
cusj-7788	78	29	,	,	PUNCT
cusj-7788	78	30	which	which	PRON
cusj-7788	78	31	may	may	AUX
cusj-7788	78	32	be	be	AUX
cusj-7788	78	33	due	due	ADJ
cusj-7788	78	34	to	to	ADP
cusj-7788	78	35	genetic	genetic	ADJ
cusj-7788	78	36	factors	factor	NOUN
cusj-7788	78	37	,	,	PUNCT
cusj-7788	78	38	such	such	ADJ
cusj-7788	78	39	as	as	ADP
cusj-7788	78	40	different	different	ADJ
cusj-7788	78	41	polymorphisms	polymorphism	NOUN
cusj-7788	78	42	in	in	ADP
cusj-7788	78	43	a3	a3	NOUN
cusj-7788	78	44	g	g	NOUN
cusj-7788	78	45	genes	gene	NOUN
cusj-7788	78	46	in	in	ADP
cusj-7788	78	47	humans	human	NOUN
cusj-7788	78	48	[	[	X
cusj-7788	78	49	9	9	NUM
cusj-7788	78	50	]	]	PUNCT
cusj-7788	78	51	,	,	PUNCT
cusj-7788	78	52	and	and	CCONJ
cusj-7788	78	53	the	the	DET
cusj-7788	78	54	context	context	NOUN
cusj-7788	78	55	of	of	ADP
cusj-7788	78	56	the	the	DET
cusj-7788	78	57	tg	tg	PROPN
cusj-7788	78	58	motif	motif	NOUN
cusj-7788	78	59	)	)	PUNCT
cusj-7788	78	60	,	,	PUNCT
cusj-7788	78	61	resulting	result	VERB
cusj-7788	78	62	in	in	ADP
cusj-7788	78	63	missense	missense	NOUN
cusj-7788	78	64	mutations	mutation	NOUN
cusj-7788	78	65	.	.	PUNCT
cusj-7788	79	1	in	in	ADP
cusj-7788	79	2	other	other	ADJ
cusj-7788	79	3	words	word	NOUN
cusj-7788	79	4	,	,	PUNCT
cusj-7788	79	5	lower	low	ADJ
cusj-7788	79	6	levels	level	NOUN
cusj-7788	79	7	of	of	ADP
cusj-7788	79	8	a3	a3	NOUN
cusj-7788	79	9	g	g	NOUN
cusj-7788	79	10	expression	expression	NOUN
cusj-7788	79	11	,	,	PUNCT
cusj-7788	79	12	would	would	AUX
cusj-7788	79	13	result	result	VERB
cusj-7788	79	14	in	in	ADP
cusj-7788	79	15	more	more	ADJ
cusj-7788	79	16	sub	sub	ADJ
cusj-7788	79	17	-	-	ADJ
cusj-7788	79	18	lethal	lethal	ADJ
cusj-7788	79	19	mutations	mutation	NOUN
cusj-7788	79	20	,	,	PUNCT
cusj-7788	79	21	compared	compare	VERB
cusj-7788	79	22	to	to	ADP
cusj-7788	79	23	higher	high	ADJ
cusj-7788	79	24	levels	level	NOUN
cusj-7788	79	25	of	of	ADP
cusj-7788	79	26	a3	a3	NOUN
cusj-7788	79	27	g	g	NOUN
cusj-7788	79	28	expression	expression	NOUN
cusj-7788	79	29	,	,	PUNCT
cusj-7788	79	30	which	which	PRON
cusj-7788	79	31	would	would	AUX
cusj-7788	79	32	mostly	mostly	ADV
cusj-7788	79	33	result	result	VERB
cusj-7788	79	34	in	in	ADP
cusj-7788	79	35	lethal	lethal	ADJ
cusj-7788	79	36	mutations	mutation	NOUN
cusj-7788	79	37	.	.	PUNCT
cusj-7788	80	1	moreover	moreover	ADV
cusj-7788	80	2	,	,	PUNCT
cusj-7788	80	3	other	other	ADJ
cusj-7788	80	4	a3	a3	NOUN
cusj-7788	80	5	proteins	protein	NOUN
cusj-7788	80	6	such	such	ADJ
cusj-7788	80	7	as	as	ADP
cusj-7788	80	8	a3d	a3d	PROPN
cusj-7788	80	9	and	and	CCONJ
cusj-7788	80	10	a3f	a3f	PROPN
cusj-7788	80	11	,	,	PUNCT
cusj-7788	80	12	respectively	respectively	ADV
cusj-7788	80	13	prefer	prefer	VERB
cusj-7788	80	14	deaminating	deaminate	VERB
cusj-7788	80	15	the	the	DET
cusj-7788	80	16	ga	ga	PROPN
cusj-7788	80	17	–	–	PUNCT
cusj-7788	80	18	aa	aa	NOUN
cusj-7788	80	19	and	and	CCONJ
cusj-7788	80	20	gaa	gaa	PROPN
cusj-7788	80	21	–	–	PUNCT
cusj-7788	80	22	aaa	aaa	NOUN
cusj-7788	80	23	motifs	motif	NOUN
cusj-7788	81	1	[	[	X
cusj-7788	81	2	5	5	NUM
cusj-7788	81	3	]	]	PUNCT
cusj-7788	81	4	,	,	PUNCT
cusj-7788	81	5	resulting	result	VERB
cusj-7788	81	6	in	in	ADP
cusj-7788	81	7	sub	sub	ADJ
cusj-7788	81	8	-	-	ADJ
cusj-7788	81	9	lethal	lethal	ADJ
cusj-7788	81	10	missense	missense	NOUN
cusj-7788	81	11	mutations	mutation	NOUN
cusj-7788	81	12	.	.	PUNCT
cusj-7788	82	1	these	these	DET
cusj-7788	82	2	missense	missense	NOUN
cusj-7788	82	3	mutations	mutation	NOUN
cusj-7788	82	4	may	may	AUX
cusj-7788	82	5	result	result	VERB
cusj-7788	82	6	in	in	ADP
cusj-7788	82	7	viral	viral	ADJ
cusj-7788	82	8	evolution	evolution	NOUN
cusj-7788	82	9	and	and	CCONJ
cusj-7788	82	10	diversification	diversification	NOUN
cusj-7788	82	11	.	.	PUNCT
cusj-7788	83	1	for	for	ADP
cusj-7788	83	2	example	example	NOUN
cusj-7788	83	3	,	,	PUNCT
cusj-7788	83	4	the	the	DET
cusj-7788	83	5	sato	sato	NOUN
cusj-7788	83	6	study	study	NOUN
cusj-7788	83	7	showed	show	VERB
cusj-7788	83	8	that	that	SCONJ
cusj-7788	83	9	a3	a3	NOUN
cusj-7788	83	10	mutations	mutation	NOUN
cusj-7788	83	11	in	in	ADP
cusj-7788	83	12	env	env	NOUN
cusj-7788	83	13	also	also	ADV
cusj-7788	83	14	changed	change	VERB
cusj-7788	83	15	the	the	DET
cusj-7788	83	16	co	co	NOUN
cusj-7788	83	17	-	-	NOUN
cusj-7788	83	18	receptor	receptor	ADJ
cusj-7788	83	19	specificity	specificity	NOUN
cusj-7788	83	20	of	of	ADP
cusj-7788	83	21	the	the	DET
cusj-7788	83	22	glycoprotein	glycoprotein	NOUN
cusj-7788	83	23	,	,	PUNCT
cusj-7788	83	24	enabling	enable	VERB
cusj-7788	83	25	it	it	PRON
cusj-7788	83	26	to	to	PART
cusj-7788	83	27	preferentially	preferentially	ADV
cusj-7788	83	28	infect	infect	VERB
cusj-7788	83	29	different	different	ADJ
cusj-7788	83	30	cell	cell	NOUN
cusj-7788	83	31	types	type	NOUN
cusj-7788	83	32	.	.	PUNCT
cusj-7788	84	1	it	it	PRON
cusj-7788	84	2	has	have	AUX
cusj-7788	84	3	been	be	AUX
cusj-7788	84	4	found	find	VERB
cusj-7788	84	5	that	that	SCONJ
cusj-7788	84	6	some	some	DET
cusj-7788	84	7	a3	a3	NOUN
cusj-7788	84	8	proteins	protein	NOUN
cusj-7788	84	9	may	may	AUX
cusj-7788	84	10	indirectly	indirectly	ADV
cusj-7788	84	11	contribute	contribute	VERB
cusj-7788	84	12	to	to	ADP
cusj-7788	84	13	retroviral	retroviral	ADJ
cusj-7788	84	14	evolution	evolution	NOUN
cusj-7788	84	15	,	,	PUNCT
cusj-7788	84	16	where	where	SCONJ
cusj-7788	84	17	the	the	DET
cusj-7788	84	18	cytidine	cytidine	NOUN
cusj-7788	84	19	deaminase	deaminase	NOUN
cusj-7788	84	20	activity	activity	NOUN
cusj-7788	84	21	of	of	ADP
cusj-7788	84	22	the	the	DET
cusj-7788	84	23	a3	a3	NOUN
cusj-7788	84	24	protein	protein	NOUN
cusj-7788	84	25	helps	help	VERB
cusj-7788	84	26	the	the	DET
cusj-7788	84	27	virus	virus	NOUN
cusj-7788	84	28	to	to	PART
cusj-7788	84	29	acquire	acquire	VERB
cusj-7788	84	30	mutations	mutation	NOUN
cusj-7788	84	31	that	that	PRON
cusj-7788	84	32	will	will	AUX
cusj-7788	84	33	make	make	VERB
cusj-7788	84	34	it	it	PRON
cusj-7788	84	35	more	more	ADV
cusj-7788	84	36	fit	fit	ADJ
cusj-7788	84	37	.	.	PUNCT
cusj-7788	85	1	studies	study	NOUN
cusj-7788	85	2	by	by	ADP
cusj-7788	85	3	kim	kim	PROPN
cusj-7788	85	4	et	et	PROPN
cusj-7788	85	5	al	al	PROPN
cusj-7788	85	6	.	.	PROPN
cusj-7788	85	7	,	,	PUNCT
cusj-7788	85	8	sato	sato	PROPN
cusj-7788	85	9	et	et	PROPN
cusj-7788	85	10	al	al	PROPN
cusj-7788	85	11	.	.	PROPN
cusj-7788	85	12	,	,	PUNCT
cusj-7788	85	13	and	and	CCONJ
cusj-7788	85	14	fourati	fourati	NOUN
cusj-7788	85	15	et	et	PROPN
cusj-7788	85	16	al	al	PROPN
cusj-7788	85	17	.	.	PROPN
cusj-7788	85	18	showed	show	VERB
cusj-7788	85	19	that	that	SCONJ
cusj-7788	85	20	retroviruses	retrovirus	NOUN
cusj-7788	85	21	,	,	PUNCT
cusj-7788	85	22	such	such	ADJ
cusj-7788	85	23	as	as	ADP
cusj-7788	85	24	hiv	hiv	PROPN
cusj-7788	85	25	,	,	PUNCT
cusj-7788	85	26	can	can	AUX
cusj-7788	85	27	sometimes	sometimes	ADV
cusj-7788	85	28	gain	gain	VERB
cusj-7788	85	29	beneficial	beneficial	ADJ
cusj-7788	85	30	mutations	mutation	NOUN
cusj-7788	85	31	that	that	PRON
cusj-7788	85	32	enable	enable	VERB
cusj-7788	85	33	them	they	PRON
cusj-7788	85	34	to	to	PART
cusj-7788	85	35	replicate	replicate	VERB
cusj-7788	85	36	better	well	ADV
cusj-7788	85	37	[	[	X
cusj-7788	85	38	3	3	NUM
cusj-7788	85	39	,	,	PUNCT
cusj-7788	85	40	5	5	NUM
cusj-7788	85	41	,	,	PUNCT
cusj-7788	85	42	6	6	NUM
cusj-7788	85	43	]	]	PUNCT
cusj-7788	85	44	.	.	PUNCT
cusj-7788	86	1	sato	sato	PROPN
cusj-7788	86	2	et	et	PROPN
cusj-7788	86	3	al	al	PROPN
cusj-7788	86	4	.	.	PROPN
cusj-7788	86	5	,	,	PUNCT
cusj-7788	86	6	fourati	fourati	PROPN
cusj-7788	86	7	et	et	PROPN
cusj-7788	86	8	al	al	PROPN
cusj-7788	86	9	.	.	PROPN
cusj-7788	86	10	,	,	PUNCT
cusj-7788	86	11	and	and	CCONJ
cusj-7788	86	12	borzooee	borzooee	VERB
cusj-7788	86	13	et	et	PROPN
cusj-7788	86	14	al	al	PROPN
cusj-7788	86	15	.	.	PROPN
cusj-7788	86	16	,	,	PUNCT
cusj-7788	86	17	also	also	ADV
cusj-7788	86	18	demonstrated	demonstrate	VERB
cusj-7788	86	19	that	that	SCONJ
cusj-7788	86	20	a3	a3	NOUN
cusj-7788	86	21	proteins	protein	NOUN
cusj-7788	86	22	such	such	ADJ
cusj-7788	86	23	as	as	ADP
cusj-7788	86	24	a3d	a3d	PROPN
cusj-7788	86	25	,	,	PUNCT
cusj-7788	86	26	a3f	a3f	ADJ
cusj-7788	86	27	,	,	PUNCT
cusj-7788	86	28	a3	a3	NOUN
cusj-7788	86	29	g	g	PROPN
cusj-7788	86	30	and	and	CCONJ
cusj-7788	86	31	a3h	a3h	NOUN
cusj-7788	86	32	can	can	AUX
cusj-7788	86	33	sometimes	sometimes	ADV
cusj-7788	86	34	lead	lead	VERB
cusj-7788	86	35	to	to	ADP
cusj-7788	86	36	retroviral	retroviral	ADJ
cusj-7788	86	37	evolution	evolution	NOUN
cusj-7788	86	38	[	[	X
cusj-7788	86	39	3	3	NUM
cusj-7788	86	40	,	,	PUNCT
cusj-7788	86	41	5	5	NUM
cusj-7788	86	42	,	,	PUNCT
cusj-7788	86	43	10	10	NUM
cusj-7788	86	44	]	]	PUNCT
cusj-7788	86	45	.	.	PUNCT
cusj-7788	87	1	it	it	PRON
cusj-7788	87	2	was	be	AUX
cusj-7788	87	3	also	also	ADV
cusj-7788	87	4	shown	show	VERB
cusj-7788	87	5	that	that	SCONJ
cusj-7788	87	6	a3	a3	NOUN
cusj-7788	87	7	proteins	protein	NOUN
cusj-7788	87	8	can	can	AUX
cusj-7788	87	9	mutate	mutate	VERB
cusj-7788	87	10	viruses	virus	NOUN
cusj-7788	87	11	so	so	SCONJ
cusj-7788	87	12	that	that	SCONJ
cusj-7788	87	13	they	they	PRON
cusj-7788	87	14	can	can	AUX
cusj-7788	87	15	use	use	VERB
cusj-7788	87	16	different	different	ADJ
cusj-7788	87	17	receptors	receptor	NOUN
cusj-7788	87	18	on	on	ADP
cusj-7788	87	19	the	the	DET
cusj-7788	87	20	cell	cell	NOUN
cusj-7788	87	21	surface	surface	NOUN
cusj-7788	87	22	for	for	ADP
cusj-7788	87	23	entry	entry	NOUN
cusj-7788	87	24	into	into	ADP
cusj-7788	87	25	the	the	DET
cusj-7788	87	26	host	host	NOUN
cusj-7788	87	27	cell	cell	NOUN
cusj-7788	88	1	[	[	X
cusj-7788	88	2	5	5	NUM
cusj-7788	88	3	]	]	PUNCT
cusj-7788	88	4	.	.	PUNCT
cusj-7788	89	1	moreover	moreover	ADV
cusj-7788	89	2	,	,	PUNCT
cusj-7788	89	3	in	in	ADP
cusj-7788	89	4	the	the	DET
cusj-7788	89	5	sato	sato	NOUN
cusj-7788	89	6	study	study	NOUN
cusj-7788	89	7	[	[	X
cusj-7788	89	8	5	5	NUM
cusj-7788	89	9	]	]	PUNCT
cusj-7788	89	10	,	,	PUNCT
cusj-7788	89	11	where	where	SCONJ
cusj-7788	89	12	humanized	humanize	VERB
cusj-7788	89	13	mice	mice	NOUN
cusj-7788	89	14	models	model	NOUN
cusj-7788	89	15	were	be	AUX
cusj-7788	89	16	used	use	VERB
cusj-7788	89	17	to	to	PART
cusj-7788	89	18	study	study	VERB
cusj-7788	89	19	different	different	ADJ
cusj-7788	89	20	vif	vif	NOUN
cusj-7788	89	21	mutants	mutant	NOUN
cusj-7788	89	22	that	that	PRON
cusj-7788	89	23	were	be	AUX
cusj-7788	89	24	initially	initially	ADV
cusj-7788	89	25	mutated	mutate	VERB
cusj-7788	89	26	via	via	ADP
cusj-7788	89	27	a3	a3	NOUN
cusj-7788	89	28	-	-	PUNCT
cusj-7788	89	29	independent	independent	ADJ
cusj-7788	89	30	means	mean	NOUN
cusj-7788	89	31	,	,	PUNCT
cusj-7788	89	32	it	it	PRON
cusj-7788	89	33	was	be	AUX
cusj-7788	89	34	found	find	VERB
cusj-7788	89	35	that	that	SCONJ
cusj-7788	89	36	a3d	a3d	PROPN
cusj-7788	89	37	and	and	CCONJ
cusj-7788	89	38	a3f	a3f	PROPN
cusj-7788	89	39	highly	highly	ADV
cusj-7788	89	40	suppressed	suppress	VERB
cusj-7788	89	41	one	one	NUM
cusj-7788	89	42	mutant	mutant	NOUN
cusj-7788	89	43	,	,	PUNCT
cusj-7788	89	44	a3	a3	NOUN
cusj-7788	89	45	g	g	PROPN
cusj-7788	89	46	highly	highly	ADV
cusj-7788	89	47	suppressed	suppress	VERB
cusj-7788	89	48	another	another	DET
cusj-7788	89	49	mutant	mutant	NOUN
cusj-7788	89	50	,	,	PUNCT
cusj-7788	89	51	and	and	CCONJ
cusj-7788	89	52	the	the	DET
cusj-7788	89	53	other	other	ADJ
cusj-7788	89	54	was	be	AUX
cusj-7788	89	55	a	a	DET
cusj-7788	89	56	double	double	ADJ
cusj-7788	89	57	mutant	mutant	NOUN
cusj-7788	89	58	,	,	PUNCT
cusj-7788	89	59	that	that	PRON
cusj-7788	89	60	was	be	AUX
cusj-7788	89	61	suppressed	suppress	VERB
cusj-7788	89	62	by	by	ADP
cusj-7788	89	63	a3d	a3d	PROPN
cusj-7788	89	64	,	,	PUNCT
cusj-7788	89	65	a3f	a3f	ADJ
cusj-7788	89	66	,	,	PUNCT
cusj-7788	89	67	and	and	CCONJ
cusj-7788	89	68	a3	a3	VERB
cusj-7788	89	69	g	g	PROPN
cusj-7788	89	70	[	[	X
cusj-7788	89	71	5	5	NUM
cusj-7788	89	72	]	]	PUNCT
cusj-7788	89	73	.	.	PUNCT
cusj-7788	90	1	it	it	PRON
cusj-7788	90	2	was	be	AUX
cusj-7788	90	3	demonstrated	demonstrate	VERB
cusj-7788	90	4	that	that	SCONJ
cusj-7788	90	5	although	although	SCONJ
cusj-7788	90	6	a	a	DET
cusj-7788	90	7	wild	wild	ADJ
cusj-7788	90	8	type	type	NOUN
cusj-7788	90	9	vif	vif	NOUN
cusj-7788	90	10	protein	protein	NOUN
cusj-7788	90	11	can	can	AUX
cusj-7788	90	12	target	target	VERB
cusj-7788	90	13	a3	a3	NOUN
cusj-7788	90	14	for	for	ADP
cusj-7788	90	15	proteasomal	proteasomal	ADJ
cusj-7788	90	16	degradation	degradation	NOUN
cusj-7788	90	17	,	,	PUNCT
cusj-7788	90	18	a	a	DET
cusj-7788	90	19	defective	defective	ADJ
cusj-7788	90	20	vif	vif	NOUN
cusj-7788	90	21	protein	protein	NOUN
cusj-7788	90	22	,	,	PUNCT
cusj-7788	90	23	could	could	AUX
cusj-7788	90	24	be	be	AUX
cusj-7788	90	25	suppressed	suppress	VERB
cusj-7788	90	26	by	by	ADP
cusj-7788	90	27	a3	a3	NOUN
cusj-7788	90	28	proteins	protein	NOUN
cusj-7788	90	29	.	.	PUNCT
cusj-7788	91	1	however	however	ADV
cusj-7788	91	2	,	,	PUNCT
cusj-7788	91	3	sometimes	sometimes	ADV
cusj-7788	91	4	these	these	DET
cusj-7788	91	5	a3	a3	NOUN
cusj-7788	91	6	-	-	PUNCT
cusj-7788	91	7	dependent	dependent	ADJ
cusj-7788	91	8	mutations	mutation	NOUN
cusj-7788	91	9	may	may	AUX
cusj-7788	91	10	benefit	benefit	VERB
cusj-7788	91	11	the	the	DET
cusj-7788	91	12	virus	virus	NOUN
cusj-7788	91	13	.	.	PUNCT
cusj-7788	92	1	in	in	ADP
cusj-7788	92	2	the	the	DET
cusj-7788	92	3	study	study	NOUN
cusj-7788	92	4	,	,	PUNCT
cusj-7788	92	5	they	they	PRON
cusj-7788	92	6	found	find	VERB
cusj-7788	92	7	that	that	SCONJ
cusj-7788	92	8	a3f	a3f	PROPN
cusj-7788	92	9	and	and	CCONJ
cusj-7788	92	10	a3d	a3d	PROPN
cusj-7788	92	11	led	lead	VERB
cusj-7788	92	12	to	to	ADP
cusj-7788	92	13	more	more	ADV
cusj-7788	92	14	viral	viral	ADJ
cusj-7788	92	15	diversification	diversification	NOUN
cusj-7788	92	16	compared	compare	VERB
cusj-7788	92	17	to	to	PART
cusj-7788	92	18	a3	a3	VERB
cusj-7788	92	19	g	g	PROPN
cusj-7788	92	20	(	(	PUNCT
cusj-7788	92	21	for	for	ADP
cusj-7788	92	22	reasons	reason	NOUN
cusj-7788	92	23	previously	previously	ADV
cusj-7788	92	24	described	describe	VERB
cusj-7788	92	25	)	)	PUNCT
cusj-7788	92	26	.	.	PUNCT
cusj-7788	93	1	these	these	DET
cusj-7788	93	2	studies	study	NOUN
cusj-7788	93	3	suggest	suggest	VERB
cusj-7788	93	4	that	that	SCONJ
cusj-7788	93	5	a3	a3	NOUN
cusj-7788	93	6	proteins	protein	NOUN
cusj-7788	93	7	could	could	AUX
cusj-7788	93	8	benefit	benefit	VERB
cusj-7788	93	9	the	the	DET
cusj-7788	93	10	virus	virus	NOUN
cusj-7788	93	11	by	by	ADP
cusj-7788	93	12	leading	lead	VERB
cusj-7788	93	13	to	to	ADP
cusj-7788	93	14	mutations	mutation	NOUN
cusj-7788	93	15	that	that	PRON
cusj-7788	93	16	will	will	AUX
cusj-7788	93	17	help	help	VERB
cusj-7788	93	18	the	the	DET
cusj-7788	93	19	virus	virus	NOUN
cusj-7788	93	20	to	to	PART
cusj-7788	93	21	overcome	overcome	VERB
cusj-7788	93	22	a3	a3	NOUN
cusj-7788	93	23	’s	’s	PART
cusj-7788	93	24	antiviral	antiviral	ADJ
cusj-7788	93	25	activity	activity	NOUN
cusj-7788	93	26	,	,	PUNCT
cusj-7788	93	27	and	and	CCONJ
cusj-7788	93	28	evade	evade	VERB
cusj-7788	93	29	antiretroviral	antiretroviral	ADJ
cusj-7788	93	30	drugs	drug	NOUN
cusj-7788	93	31	detection	detection	NOUN
cusj-7788	93	32	,	,	PUNCT
cusj-7788	93	33	leading	lead	VERB
cusj-7788	93	34	to	to	ADP
cusj-7788	93	35	viral	viral	ADJ
cusj-7788	93	36	escape	escape	NOUN
cusj-7788	93	37	.	.	PUNCT
cusj-7788	94	1	this	this	PRON
cusj-7788	94	2	will	will	AUX
cusj-7788	94	3	enable	enable	VERB
cusj-7788	94	4	them	they	PRON
cusj-7788	94	5	to	to	PART
cusj-7788	94	6	continue	continue	VERB
cusj-7788	94	7	to	to	PART
cusj-7788	94	8	undergo	undergo	VERB
cusj-7788	94	9	replication	replication	NOUN
cusj-7788	94	10	and	and	CCONJ
cusj-7788	94	11	infection	infection	NOUN
cusj-7788	94	12	in	in	ADP
cusj-7788	94	13	additional	additional	ADJ
cusj-7788	94	14	cells	cell	NOUN
cusj-7788	94	15	.	.	PUNCT
cusj-7788	95	1	in	in	ADP
cusj-7788	95	2	other	other	ADJ
cusj-7788	95	3	words	word	NOUN
cusj-7788	95	4	,	,	PUNCT
cusj-7788	95	5	the	the	DET
cusj-7788	95	6	a3	a3	NOUN
cusj-7788	95	7	proteins	protein	NOUN
cusj-7788	95	8	assist	assist	VERB
cusj-7788	95	9	the	the	DET
cusj-7788	95	10	virus	virus	NOUN
cusj-7788	95	11	by	by	ADP
cusj-7788	95	12	enabling	enable	VERB
cusj-7788	95	13	them	they	PRON
cusj-7788	95	14	to	to	PART
cusj-7788	95	15	gain	gain	VERB
cusj-7788	95	16	diversity	diversity	NOUN
cusj-7788	95	17	,	,	PUNCT
cusj-7788	95	18	which	which	PRON
cusj-7788	95	19	in	in	ADP
cusj-7788	95	20	turn	turn	NOUN
cusj-7788	95	21	may	may	AUX
cusj-7788	95	22	help	help	VERB
cusj-7788	95	23	the	the	DET
cusj-7788	95	24	virus	virus	NOUN
cusj-7788	95	25	to	to	PART
cusj-7788	95	26	acquire	acquire	VERB
cusj-7788	95	27	mutations	mutation	NOUN
cusj-7788	95	28	that	that	PRON
cusj-7788	95	29	make	make	VERB
cusj-7788	95	30	it	it	PRON
cusj-7788	95	31	gain	gain	VERB
cusj-7788	95	32	drug	drug	NOUN
cusj-7788	95	33	resistance	resistance	NOUN
cusj-7788	95	34	.	.	PUNCT
cusj-7788	96	1	drug	drug	NOUN
cusj-7788	96	2	resistance	resistance	NOUN
cusj-7788	96	3	drug	drug	NOUN
cusj-7788	96	4	resistance	resistance	NOUN
cusj-7788	96	5	refers	refer	VERB
cusj-7788	96	6	to	to	ADP
cusj-7788	96	7	the	the	DET
cusj-7788	96	8	ability	ability	NOUN
cusj-7788	96	9	of	of	ADP
cusj-7788	96	10	a	a	DET
cusj-7788	96	11	pathogen	pathogen	NOUN
cusj-7788	96	12	to	to	PART
cusj-7788	96	13	overcome	overcome	VERB
cusj-7788	96	14	the	the	DET
cusj-7788	96	15	effects	effect	NOUN
cusj-7788	96	16	of	of	ADP
cusj-7788	96	17	a	a	DET
cusj-7788	96	18	drug	drug	NOUN
cusj-7788	96	19	.	.	PUNCT
cusj-7788	97	1	this	this	PRON
cusj-7788	97	2	usually	usually	ADV
cusj-7788	97	3	occurs	occur	VERB
cusj-7788	97	4	when	when	SCONJ
cusj-7788	97	5	a	a	DET
cusj-7788	97	6	certain	certain	ADJ
cusj-7788	97	7	drug	drug	NOUN
cusj-7788	97	8	is	be	AUX
cusj-7788	97	9	continuously	continuously	ADV
cusj-7788	97	10	used	use	VERB
cusj-7788	97	11	to	to	PART
cusj-7788	97	12	treat	treat	VERB
cusj-7788	97	13	a	a	DET
cusj-7788	97	14	particular	particular	ADJ
cusj-7788	97	15	infection	infection	NOUN
cusj-7788	97	16	,	,	PUNCT
cusj-7788	97	17	and	and	CCONJ
cusj-7788	97	18	due	due	ADP
cusj-7788	97	19	to	to	ADP
cusj-7788	97	20	constant	constant	ADJ
cusj-7788	97	21	exposure	exposure	NOUN
cusj-7788	97	22	of	of	ADP
cusj-7788	97	23	the	the	DET
cusj-7788	97	24	disease	disease	NOUN
cusj-7788	97	25	pathogen	pathogen	NOUN
cusj-7788	97	26	to	to	ADP
cusj-7788	97	27	the	the	DET
cusj-7788	97	28	drug	drug	NOUN
cusj-7788	97	29	,	,	PUNCT
cusj-7788	97	30	the	the	DET
cusj-7788	97	31	drug	drug	NOUN
cusj-7788	97	32	becomes	become	VERB
cusj-7788	97	33	less	less	ADV
cusj-7788	97	34	effective	effective	ADJ
cusj-7788	97	35	,	,	PUNCT
cusj-7788	97	36	usually	usually	ADV
cusj-7788	97	37	because	because	SCONJ
cusj-7788	97	38	the	the	DET
cusj-7788	97	39	pathogen	pathogen	NOUN
cusj-7788	97	40	acquires	acquire	VERB
cusj-7788	97	41	drug	drug	NOUN
cusj-7788	97	42	-	-	PUNCT
cusj-7788	97	43	resistance	resistance	NOUN
cusj-7788	97	44	gene	gene	NOUN
cusj-7788	97	45	mutations	mutation	NOUN
cusj-7788	97	46	.	.	PUNCT
cusj-7788	98	1	to	to	PART
cusj-7788	98	2	minimize	minimize	VERB
cusj-7788	98	3	the	the	DET
cusj-7788	98	4	possibility	possibility	NOUN
cusj-7788	98	5	of	of	ADP
cusj-7788	98	6	disease	disease	NOUN
cusj-7788	98	7	pathogens	pathogen	NOUN
cusj-7788	98	8	gaining	gain	VERB
cusj-7788	98	9	resistance	resistance	NOUN
cusj-7788	98	10	,	,	PUNCT
cusj-7788	98	11	multiple	multiple	ADJ
cusj-7788	98	12	drugs	drug	NOUN
cusj-7788	98	13	could	could	AUX
cusj-7788	98	14	be	be	AUX
cusj-7788	98	15	used	use	VERB
cusj-7788	98	16	for	for	ADP
cusj-7788	98	17	the	the	DET
cusj-7788	98	18	treatment	treatment	NOUN
cusj-7788	98	19	of	of	ADP
cusj-7788	98	20	that	that	DET
cusj-7788	98	21	disease	disease	NOUN
cusj-7788	98	22	.	.	PUNCT
cusj-7788	99	1	this	this	PRON
cusj-7788	99	2	is	be	AUX
cusj-7788	99	3	usually	usually	ADV
cusj-7788	99	4	seen	see	VERB
cusj-7788	99	5	in	in	ADP
cusj-7788	99	6	the	the	DET
cusj-7788	99	7	treatment	treatment	NOUN
cusj-7788	99	8	of	of	ADP
cusj-7788	99	9	certain	certain	ADJ
cusj-7788	99	10	diseases	disease	NOUN
cusj-7788	99	11	,	,	PUNCT
cusj-7788	99	12	such	such	ADJ
cusj-7788	99	13	as	as	ADP
cusj-7788	99	14	hiv	hiv	PROPN
cusj-7788	99	15	,	,	PUNCT
cusj-7788	99	16	where	where	SCONJ
cusj-7788	99	17	a	a	DET
cusj-7788	99	18	combination	combination	NOUN
cusj-7788	99	19	of	of	ADP
cusj-7788	99	20	different	different	ADJ
cusj-7788	99	21	drugs	drug	NOUN
cusj-7788	99	22	(	(	PUNCT
cusj-7788	99	23	such	such	ADJ
cusj-7788	99	24	as	as	ADP
cusj-7788	99	25	highly	highly	ADV
cusj-7788	99	26	active	active	ADJ
cusj-7788	99	27	antiretroviral	antiretroviral	ADJ
cusj-7788	99	28	therapy	therapy	NOUN
cusj-7788	99	29	,	,	PUNCT
cusj-7788	99	30	haart	haart	PROPN
cusj-7788	99	31	)	)	PUNCT
cusj-7788	99	32	are	be	AUX
cusj-7788	99	33	used	use	VERB
cusj-7788	99	34	simultaneously	simultaneously	ADV
cusj-7788	99	35	to	to	PART
cusj-7788	99	36	prevent	prevent	VERB
cusj-7788	99	37	the	the	DET
cusj-7788	99	38	emergence	emergence	NOUN
cusj-7788	99	39	of	of	ADP
cusj-7788	99	40	drug	drug	NOUN
cusj-7788	99	41	-	-	PUNCT
cusj-7788	99	42	resistant	resistant	ADJ
cusj-7788	99	43	virus	virus	NOUN
cusj-7788	99	44	.	.	PUNCT
cusj-7788	100	1	however	however	ADV
cusj-7788	100	2	,	,	PUNCT
cusj-7788	100	3	g	g	NOUN
cusj-7788	100	4	-	-	PUNCT
cusj-7788	100	5	to	to	ADP
cusj-7788	100	6	-	-	PUNCT
cusj-7788	100	7	a	a	DET
cusj-7788	100	8	mutations	mutation	NOUN
cusj-7788	100	9	caused	cause	VERB
cusj-7788	100	10	by	by	ADP
cusj-7788	100	11	a3	a3	NOUN
cusj-7788	100	12	proteins	protein	NOUN
cusj-7788	100	13	in	in	ADP
cusj-7788	100	14	the	the	DET
cusj-7788	100	15	retrovirus	retrovirus	NOUN
cusj-7788	100	16	may	may	AUX
cusj-7788	100	17	cause	cause	VERB
cusj-7788	100	18	the	the	DET
cusj-7788	100	19	retrovirus	retrovirus	NOUN
cusj-7788	100	20	to	to	PART
cusj-7788	100	21	gain	gain	VERB
cusj-7788	100	22	mutations	mutation	NOUN
cusj-7788	100	23	that	that	PRON
cusj-7788	100	24	enable	enable	VERB
cusj-7788	100	25	it	it	PRON
cusj-7788	100	26	to	to	PART
cusj-7788	100	27	become	become	VERB
cusj-7788	100	28	drug	drug	NOUN
cusj-7788	100	29	-	-	PUNCT
cusj-7788	100	30	resistant	resistant	ADJ
cusj-7788	100	31	.	.	PUNCT
cusj-7788	101	1	as	as	SCONJ
cusj-7788	101	2	shown	show	VERB
cusj-7788	101	3	in	in	ADP
cusj-7788	101	4	the	the	DET
cusj-7788	101	5	study	study	NOUN
cusj-7788	101	6	by	by	ADP
cusj-7788	101	7	fourati	fourati	PROPN
cusj-7788	101	8	et	et	PROPN
cusj-7788	101	9	al	al	PROPN
cusj-7788	101	10	.	.	PROPN
cusj-7788	101	11	,	,	PUNCT
cusj-7788	101	12	peripheral	peripheral	ADJ
cusj-7788	101	13	blood	blood	NOUN
cusj-7788	101	14	mononuclear	mononuclear	ADJ
cusj-7788	101	15	cells	cell	NOUN
cusj-7788	101	16	(	(	PUNCT
cusj-7788	101	17	pbmcs	pbmcs	NOUN
cusj-7788	101	18	)	)	PUNCT
cusj-7788	101	19	and	and	CCONJ
cusj-7788	101	20	other	other	ADJ
cusj-7788	101	21	body	body	NOUN
cusj-7788	101	22	fluids	fluid	NOUN
cusj-7788	101	23	/	/	SYM
cusj-7788	101	24	tissues	tissue	NOUN
cusj-7788	101	25	obtained	obtain	VERB
cusj-7788	101	26	from	from	ADP
cusj-7788	101	27	30	30	NUM
cusj-7788	101	28	haart	haart	PROPN
cusj-7788	101	29	-	-	PUNCT
cusj-7788	101	30	treated	treat	VERB
cusj-7788	101	31	patients	patient	NOUN
cusj-7788	101	32	were	be	AUX
cusj-7788	101	33	examined	examine	VERB
cusj-7788	101	34	for	for	ADP
cusj-7788	101	35	possible	possible	ADJ
cusj-7788	101	36	drug	drug	NOUN
cusj-7788	101	37	-	-	PUNCT
cusj-7788	101	38	resistance	resistance	NOUN
cusj-7788	101	39	mutations	mutation	NOUN
cusj-7788	101	40	.	.	PUNCT
cusj-7788	102	1	it	it	PRON
cusj-7788	102	2	was	be	AUX
cusj-7788	102	3	found	find	VERB
cusj-7788	102	4	that	that	SCONJ
cusj-7788	102	5	a3	a3	NOUN
cusj-7788	102	6	-	-	PUNCT
cusj-7788	102	7	dependent	dependent	ADJ
cusj-7788	102	8	hypermutations	hypermutation	NOUN
cusj-7788	102	9	in	in	ADP
cusj-7788	102	10	addition	addition	NOUN
cusj-7788	102	11	to	to	ADP
cusj-7788	102	12	viral	viral	ADJ
cusj-7788	102	13	recombination	recombination	NOUN
cusj-7788	102	14	could	could	AUX
cusj-7788	102	15	lead	lead	VERB
cusj-7788	102	16	to	to	ADP
cusj-7788	102	17	viral	viral	ADJ
cusj-7788	102	18	evolution	evolution	NOUN
cusj-7788	103	1	[	[	X
cusj-7788	103	2	6	6	NUM
cusj-7788	103	3	]	]	PUNCT
cusj-7788	103	4	.	.	PUNCT
cusj-7788	104	1	columbia	columbia	PROPN
cusj-7788	104	2	undergraduate	undergraduate	PROPN
cusj-7788	104	3	science	science	PROPN
cusj-7788	104	4	journal	journal	PROPN
cusj-7788	104	5	vol	vol	NOUN
cusj-7788	104	6	.	.	PROPN
cusj-7788	104	7	15	15	NUM
cusj-7788	104	8	,	,	PUNCT
cusj-7788	104	9	2021	2021	NUM
cusj-7788	104	10	obikili	obikili	NOUN
cusj-7788	104	11	59	59	NUM
cusj-7788	104	12	additionally	additionally	ADV
cusj-7788	104	13	,	,	PUNCT
cusj-7788	104	14	in	in	ADP
cusj-7788	104	15	a	a	DET
cusj-7788	104	16	study	study	NOUN
cusj-7788	104	17	by	by	ADP
cusj-7788	104	18	mulder	mulder	PROPN
cusj-7788	104	19	et	et	PROPN
cusj-7788	104	20	al	al	PROPN
cusj-7788	104	21	.	.	PROPN
cusj-7788	104	22	,	,	PUNCT
cusj-7788	104	23	it	it	PRON
cusj-7788	104	24	was	be	AUX
cusj-7788	104	25	found	find	VERB
cusj-7788	104	26	that	that	SCONJ
cusj-7788	104	27	g	g	NOUN
cusj-7788	104	28	-	-	PUNCT
cusj-7788	104	29	to	to	ADP
cusj-7788	104	30	-	-	PUNCT
cusj-7788	104	31	a	a	DET
cusj-7788	104	32	hypermutations	hypermutation	NOUN
cusj-7788	104	33	caused	cause	VERB
cusj-7788	104	34	by	by	ADP
cusj-7788	104	35	a3	a3	NOUN
cusj-7788	104	36	g	g	PROPN
cusj-7788	104	37	reduces	reduce	VERB
cusj-7788	104	38	the	the	DET
cusj-7788	104	39	viral	viral	ADJ
cusj-7788	104	40	infectivity	infectivity	NOUN
cusj-7788	104	41	and	and	CCONJ
cusj-7788	104	42	could	could	AUX
cusj-7788	104	43	also	also	ADV
cusj-7788	104	44	lead	lead	VERB
cusj-7788	104	45	to	to	ADP
cusj-7788	104	46	viral	viral	ADJ
cusj-7788	104	47	diversification	diversification	NOUN
cusj-7788	105	1	[	[	X
cusj-7788	105	2	11	11	NUM
cusj-7788	105	3	]	]	PUNCT
cusj-7788	105	4	.	.	PUNCT
cusj-7788	106	1	in	in	ADP
cusj-7788	106	2	this	this	DET
cusj-7788	106	3	study	study	NOUN
cusj-7788	106	4	,	,	PUNCT
cusj-7788	106	5	it	it	PRON
cusj-7788	106	6	was	be	AUX
cusj-7788	106	7	demonstrated	demonstrate	VERB
cusj-7788	106	8	that	that	SCONJ
cusj-7788	106	9	defective	defective	ADJ
cusj-7788	106	10	vif	vif	NOUN
cusj-7788	106	11	mutants	mutant	NOUN
cusj-7788	106	12	with	with	ADP
cusj-7788	106	13	suboptimal	suboptimal	ADJ
cusj-7788	106	14	anti	anti	ADJ
cusj-7788	106	15	-	-	ADJ
cusj-7788	106	16	a3	a3	ADJ
cusj-7788	106	17	g	g	NOUN
cusj-7788	106	18	activity	activity	NOUN
cusj-7788	106	19	could	could	AUX
cusj-7788	106	20	lead	lead	VERB
cusj-7788	106	21	to	to	ADP
cusj-7788	106	22	the	the	DET
cusj-7788	106	23	production	production	NOUN
cusj-7788	106	24	of	of	ADP
cusj-7788	106	25	proviruses	provirus	NOUN
cusj-7788	106	26	resistant	resistant	ADJ
cusj-7788	106	27	to	to	ADP
cusj-7788	106	28	the	the	DET
cusj-7788	106	29	drug	drug	NOUN
cusj-7788	106	30	lamivudine	lamivudine	NOUN
cusj-7788	106	31	(	(	PUNCT
cusj-7788	106	32	3tc	3tc	NOUN
cusj-7788	106	33	)	)	PUNCT
cusj-7788	106	34	(	(	PUNCT
cusj-7788	106	35	which	which	PRON
cusj-7788	106	36	inhibits	inhibit	VERB
cusj-7788	106	37	the	the	DET
cusj-7788	106	38	retroviral	retroviral	ADJ
cusj-7788	106	39	reverse	reverse	NOUN
cusj-7788	106	40	transcriptase	transcriptase	NOUN
cusj-7788	106	41	)	)	PUNCT
cusj-7788	106	42	before	before	ADP
cusj-7788	106	43	drug	drug	NOUN
cusj-7788	106	44	exposure	exposure	NOUN
cusj-7788	106	45	.	.	PUNCT
cusj-7788	107	1	although	although	SCONJ
cusj-7788	107	2	the	the	DET
cusj-7788	107	3	proviruses	provirus	NOUN
cusj-7788	107	4	were	be	AUX
cusj-7788	107	5	not	not	PART
cusj-7788	107	6	able	able	ADJ
cusj-7788	107	7	to	to	PART
cusj-7788	107	8	replicate	replicate	VERB
cusj-7788	107	9	,	,	PUNCT
cusj-7788	107	10	when	when	SCONJ
cusj-7788	107	11	they	they	PRON
cusj-7788	107	12	recombined	recombine	VERB
cusj-7788	107	13	with	with	ADP
cusj-7788	107	14	wild	wild	ADJ
cusj-7788	107	15	-	-	PUNCT
cusj-7788	107	16	type	type	NOUN
cusj-7788	107	17	hiv-1	hiv-1	NOUN
cusj-7788	107	18	,	,	PUNCT
cusj-7788	107	19	they	they	PRON
cusj-7788	107	20	produced	produce	VERB
cusj-7788	107	21	competent	competent	ADJ
cusj-7788	107	22	viruses	virus	NOUN
cusj-7788	107	23	that	that	PRON
cusj-7788	107	24	were	be	AUX
cusj-7788	107	25	resistant	resistant	ADJ
cusj-7788	107	26	to	to	ADP
cusj-7788	107	27	the	the	DET
cusj-7788	107	28	drug	drug	NOUN
cusj-7788	107	29	3tc	3tc	NOUN
cusj-7788	108	1	[	[	X
cusj-7788	108	2	11	11	NUM
cusj-7788	108	3	]	]	PUNCT
cusj-7788	108	4	.	.	PUNCT
cusj-7788	109	1	in	in	ADP
cusj-7788	109	2	a	a	DET
cusj-7788	109	3	similar	similar	ADJ
cusj-7788	109	4	study	study	NOUN
cusj-7788	109	5	by	by	ADP
cusj-7788	109	6	hernandez	hernandez	PROPN
cusj-7788	109	7	et	et	PROPN
cusj-7788	109	8	al	al	PROPN
cusj-7788	109	9	.	.	PROPN
cusj-7788	109	10	,	,	PUNCT
cusj-7788	109	11	it	it	PRON
cusj-7788	109	12	was	be	AUX
cusj-7788	109	13	found	find	VERB
cusj-7788	109	14	that	that	SCONJ
cusj-7788	109	15	sublethal	sublethal	NOUN
cusj-7788	109	16	mutations	mutation	NOUN
cusj-7788	109	17	induced	induce	VERB
cusj-7788	109	18	by	by	ADP
cusj-7788	109	19	a3	a3	NOUN
cusj-7788	109	20	g	g	PROPN
cusj-7788	109	21	could	could	AUX
cusj-7788	109	22	lead	lead	VERB
cusj-7788	109	23	to	to	ADP
cusj-7788	109	24	viral	viral	ADJ
cusj-7788	109	25	diversification	diversification	NOUN
cusj-7788	109	26	.	.	PUNCT
cusj-7788	110	1	they	they	PRON
cusj-7788	110	2	infected	infect	VERB
cusj-7788	110	3	humanized	humanize	VERB
cusj-7788	110	4	mice	mouse	NOUN
cusj-7788	110	5	with	with	ADP
cusj-7788	110	6	different	different	ADJ
cusj-7788	110	7	variants	variant	NOUN
cusj-7788	110	8	of	of	ADP
cusj-7788	110	9	hiv	hiv	PROPN
cusj-7788	110	10	(	(	PUNCT
cusj-7788	110	11	that	that	PRON
cusj-7788	110	12	were	be	AUX
cusj-7788	110	13	mutated	mutate	VERB
cusj-7788	110	14	via	via	ADP
cusj-7788	110	15	a3	a3	NOUN
cusj-7788	110	16	-	-	PUNCT
cusj-7788	110	17	independent	independent	ADJ
cusj-7788	110	18	means	mean	NOUN
cusj-7788	110	19	)	)	PUNCT
cusj-7788	110	20	,	,	PUNCT
cusj-7788	110	21	and	and	CCONJ
cusj-7788	110	22	they	they	PRON
cusj-7788	110	23	found	find	VERB
cusj-7788	110	24	that	that	SCONJ
cusj-7788	110	25	the	the	DET
cusj-7788	110	26	wild	wild	ADJ
cusj-7788	110	27	type	type	NOUN
cusj-7788	110	28	hiv	hiv	PROPN
cusj-7788	110	29	strain	strain	NOUN
cusj-7788	110	30	had	have	VERB
cusj-7788	110	31	a	a	DET
cusj-7788	110	32	higher	high	ADJ
cusj-7788	110	33	fitness	fitness	NOUN
cusj-7788	110	34	compared	compare	VERB
cusj-7788	110	35	to	to	ADP
cusj-7788	110	36	the	the	DET
cusj-7788	110	37	mutant	mutant	NOUN
cusj-7788	110	38	strains	strain	VERB
cusj-7788	110	39	prior	prior	ADV
cusj-7788	110	40	to	to	ADP
cusj-7788	110	41	its	its	PRON
cusj-7788	110	42	treatment	treatment	NOUN
cusj-7788	110	43	with	with	ADP
cusj-7788	110	44	3tc	3tc	NOUN
cusj-7788	111	1	[	[	X
cusj-7788	111	2	12	12	NUM
cusj-7788	111	3	]	]	PUNCT
cusj-7788	111	4	.	.	PUNCT
cusj-7788	112	1	however	however	ADV
cusj-7788	112	2	,	,	PUNCT
cusj-7788	112	3	when	when	SCONJ
cusj-7788	112	4	they	they	PRON
cusj-7788	112	5	started	start	VERB
cusj-7788	112	6	the	the	DET
cusj-7788	112	7	treatment	treatment	NOUN
cusj-7788	112	8	with	with	ADP
cusj-7788	112	9	the	the	DET
cusj-7788	112	10	drug	drug	NOUN
cusj-7788	112	11	,	,	PUNCT
cusj-7788	112	12	they	they	PRON
cusj-7788	112	13	found	find	VERB
cusj-7788	112	14	that	that	SCONJ
cusj-7788	112	15	the	the	DET
cusj-7788	112	16	mutant	mutant	ADJ
cusj-7788	112	17	strain	strain	NOUN
cusj-7788	112	18	was	be	AUX
cusj-7788	112	19	less	less	ADV
cusj-7788	112	20	susceptible	susceptible	ADJ
cusj-7788	112	21	to	to	ADP
cusj-7788	112	22	the	the	DET
cusj-7788	112	23	antiretroviral	antiretroviral	ADJ
cusj-7788	112	24	drug	drug	NOUN
cusj-7788	112	25	’s	’s	PART
cusj-7788	112	26	effect	effect	NOUN
cusj-7788	112	27	because	because	SCONJ
cusj-7788	112	28	of	of	ADP
cusj-7788	112	29	its	its	PRON
cusj-7788	112	30	defectiveness	defectiveness	NOUN
cusj-7788	112	31	.	.	PUNCT
cusj-7788	113	1	in	in	ADP
cusj-7788	113	2	other	other	ADJ
cusj-7788	113	3	words	word	NOUN
cusj-7788	113	4	,	,	PUNCT
cusj-7788	113	5	because	because	SCONJ
cusj-7788	113	6	the	the	DET
cusj-7788	113	7	mutant	mutant	NOUN
cusj-7788	113	8	hiv	hiv	PROPN
cusj-7788	113	9	strain	strain	NOUN
cusj-7788	113	10	is	be	AUX
cusj-7788	113	11	less	less	ADV
cusj-7788	113	12	fit	fit	ADJ
cusj-7788	113	13	,	,	PUNCT
cusj-7788	113	14	the	the	DET
cusj-7788	113	15	drug	drug	NOUN
cusj-7788	113	16	has	have	VERB
cusj-7788	113	17	a	a	DET
cusj-7788	113	18	decreased	decrease	VERB
cusj-7788	113	19	effect	effect	NOUN
cusj-7788	113	20	on	on	ADP
cusj-7788	113	21	it	it	PRON
cusj-7788	113	22	compared	compare	VERB
cusj-7788	113	23	to	to	ADP
cusj-7788	113	24	the	the	DET
cusj-7788	113	25	wild	wild	ADJ
cusj-7788	113	26	type	type	NOUN
cusj-7788	113	27	,	,	PUNCT
cusj-7788	113	28	hence	hence	ADV
cusj-7788	113	29	the	the	DET
cusj-7788	113	30	mutant	mutant	NOUN
cusj-7788	113	31	strains	strain	NOUN
cusj-7788	113	32	become	become	VERB
cusj-7788	113	33	resistant	resistant	ADJ
cusj-7788	113	34	to	to	ADP
cusj-7788	113	35	the	the	DET
cusj-7788	113	36	drug	drug	NOUN
cusj-7788	113	37	[	[	X
cusj-7788	113	38	12	12	NUM
cusj-7788	113	39	]	]	PUNCT
cusj-7788	113	40	.	.	PUNCT
cusj-7788	114	1	thus	thus	ADV
cusj-7788	114	2	,	,	PUNCT
cusj-7788	114	3	these	these	DET
cusj-7788	114	4	studies	study	NOUN
cusj-7788	114	5	show	show	VERB
cusj-7788	114	6	that	that	SCONJ
cusj-7788	114	7	sublethal	sublethal	NOUN
cusj-7788	114	8	mutations	mutation	NOUN
cusj-7788	114	9	caused	cause	VERB
cusj-7788	114	10	by	by	ADP
cusj-7788	114	11	a3	a3	NOUN
cusj-7788	114	12	g	g	NOUN
cusj-7788	114	13	,	,	PUNCT
cusj-7788	114	14	increase	increase	VERB
cusj-7788	114	15	viral	viral	ADJ
cusj-7788	114	16	diversification	diversification	NOUN
cusj-7788	114	17	which	which	PRON
cusj-7788	114	18	could	could	AUX
cusj-7788	114	19	make	make	VERB
cusj-7788	114	20	the	the	DET
cusj-7788	114	21	virus	virus	NOUN
cusj-7788	114	22	gain	gain	VERB
cusj-7788	114	23	resistance	resistance	NOUN
cusj-7788	114	24	to	to	ADP
cusj-7788	114	25	certain	certain	ADJ
cusj-7788	114	26	drugs	drug	NOUN
cusj-7788	114	27	.	.	PUNCT
cusj-7788	115	1	these	these	DET
cusj-7788	115	2	mutations	mutation	NOUN
cusj-7788	115	3	could	could	AUX
cusj-7788	115	4	also	also	ADV
cusj-7788	115	5	enable	enable	VERB
cusj-7788	115	6	the	the	DET
cusj-7788	115	7	virus	virus	NOUN
cusj-7788	115	8	to	to	PART
cusj-7788	115	9	undergo	undergo	VERB
cusj-7788	115	10	immune	immune	ADJ
cusj-7788	115	11	escape	escape	NOUN
cusj-7788	115	12	.	.	PUNCT
cusj-7788	115	13	immune	immune	ADJ
cusj-7788	115	14	escape	escape	NOUN
cusj-7788	115	15	immune	immune	ADJ
cusj-7788	115	16	escape	escape	NOUN
cusj-7788	115	17	refers	refer	VERB
cusj-7788	115	18	to	to	ADP
cusj-7788	115	19	a	a	DET
cusj-7788	115	20	situation	situation	NOUN
cusj-7788	115	21	where	where	SCONJ
cusj-7788	115	22	a	a	DET
cusj-7788	115	23	pathogen	pathogen	NOUN
cusj-7788	115	24	evades	evade	VERB
cusj-7788	115	25	detection	detection	NOUN
cusj-7788	115	26	by	by	ADP
cusj-7788	115	27	the	the	DET
cusj-7788	115	28	host	host	NOUN
cusj-7788	115	29	’s	’s	PART
cusj-7788	115	30	immune	immune	ADJ
cusj-7788	115	31	system	system	NOUN
cusj-7788	115	32	.	.	PUNCT
cusj-7788	116	1	in	in	ADP
cusj-7788	116	2	the	the	DET
cusj-7788	116	3	case	case	NOUN
cusj-7788	116	4	of	of	ADP
cusj-7788	116	5	retroviruses	retrovirus	NOUN
cusj-7788	116	6	,	,	PUNCT
cusj-7788	116	7	this	this	DET
cusj-7788	116	8	immune	immune	ADJ
cusj-7788	116	9	escape	escape	NOUN
cusj-7788	116	10	can	can	AUX
cusj-7788	116	11	be	be	AUX
cusj-7788	116	12	aided	aid	VERB
cusj-7788	116	13	by	by	ADP
cusj-7788	116	14	a3	a3	NOUN
cusj-7788	116	15	proteins	protein	NOUN
cusj-7788	116	16	[	[	X
cusj-7788	116	17	1	1	NUM
cusj-7788	116	18	,	,	PUNCT
cusj-7788	116	19	10	10	NUM
cusj-7788	116	20	,	,	PUNCT
cusj-7788	116	21	13	13	NUM
cusj-7788	116	22	]	]	PUNCT
cusj-7788	116	23	.	.	PUNCT
cusj-7788	117	1	as	as	SCONJ
cusj-7788	117	2	mentioned	mention	VERB
cusj-7788	117	3	earlier	early	ADV
cusj-7788	117	4	,	,	PUNCT
cusj-7788	117	5	a3	a3	NOUN
cusj-7788	117	6	proteins	protein	NOUN
cusj-7788	117	7	may	may	AUX
cusj-7788	117	8	sometimes	sometimes	ADV
cusj-7788	117	9	cause	cause	VERB
cusj-7788	117	10	sublethal	sublethal	NOUN
cusj-7788	117	11	mutations	mutation	NOUN
cusj-7788	117	12	,	,	PUNCT
cusj-7788	117	13	which	which	PRON
cusj-7788	117	14	could	could	AUX
cusj-7788	117	15	help	help	VERB
cusj-7788	117	16	the	the	DET
cusj-7788	117	17	virus	virus	NOUN
cusj-7788	117	18	to	to	PART
cusj-7788	117	19	avoid	avoid	VERB
cusj-7788	117	20	detection	detection	NOUN
cusj-7788	117	21	by	by	ADP
cusj-7788	117	22	cytotoxic	cytotoxic	ADJ
cusj-7788	117	23	t	t	NOUN
cusj-7788	117	24	cells	cell	NOUN
cusj-7788	117	25	(	(	PUNCT
cusj-7788	117	26	ctl	ctl	PROPN
cusj-7788	117	27	)	)	PUNCT
cusj-7788	117	28	,	,	PUNCT
cusj-7788	117	29	which	which	PRON
cusj-7788	117	30	kill	kill	VERB
cusj-7788	117	31	infected	infected	ADJ
cusj-7788	117	32	cells	cell	NOUN
cusj-7788	117	33	[	[	X
cusj-7788	117	34	1	1	NUM
cusj-7788	117	35	,	,	PUNCT
cusj-7788	117	36	10	10	NUM
cusj-7788	117	37	,	,	PUNCT
cusj-7788	117	38	13	13	NUM
cusj-7788	117	39	]	]	PUNCT
cusj-7788	117	40	.	.	PUNCT
cusj-7788	118	1	these	these	DET
cusj-7788	118	2	sublethal	sublethal	NOUN
cusj-7788	118	3	mutations	mutation	NOUN
cusj-7788	118	4	may	may	AUX
cusj-7788	118	5	alter	alter	VERB
cusj-7788	118	6	ctl	ctl	PROPN
cusj-7788	118	7	epitopes	epitope	NOUN
cusj-7788	118	8	or	or	CCONJ
cusj-7788	118	9	lead	lead	VERB
cusj-7788	118	10	to	to	ADP
cusj-7788	118	11	mutations	mutation	NOUN
cusj-7788	118	12	that	that	PRON
cusj-7788	118	13	alter	alter	VERB
cusj-7788	118	14	peptide	peptide	NOUN
cusj-7788	118	15	degradation	degradation	NOUN
cusj-7788	118	16	and	and	CCONJ
cusj-7788	118	17	its	its	PRON
cusj-7788	118	18	presentation	presentation	NOUN
cusj-7788	118	19	by	by	ADP
cusj-7788	118	20	the	the	DET
cusj-7788	118	21	human	human	ADJ
cusj-7788	118	22	leukocyte	leukocyte	NOUN
cusj-7788	118	23	antigen	antigen	NOUN
cusj-7788	118	24	(	(	PUNCT
cusj-7788	118	25	hla	hla	NOUN
cusj-7788	118	26	)	)	PUNCT
cusj-7788	118	27	proteins	protein	NOUN
cusj-7788	118	28	on	on	ADP
cusj-7788	118	29	the	the	DET
cusj-7788	118	30	cell	cell	NOUN
cusj-7788	118	31	surface	surface	NOUN
cusj-7788	119	1	[	[	X
cusj-7788	119	2	10	10	NUM
cusj-7788	119	3	,	,	PUNCT
cusj-7788	119	4	13	13	NUM
cusj-7788	119	5	]	]	PUNCT
cusj-7788	119	6	.	.	PUNCT
cusj-7788	120	1	hla	hla	PROPN
cusj-7788	120	2	proteins	protein	NOUN
cusj-7788	120	3	are	be	AUX
cusj-7788	120	4	human	human	ADJ
cusj-7788	120	5	major	major	ADJ
cusj-7788	120	6	histocompatibility	histocompatibility	NOUN
cusj-7788	120	7	complex	complex	NOUN
cusj-7788	120	8	(	(	PUNCT
cusj-7788	120	9	mhc	mhc	NOUN
cusj-7788	120	10	)	)	PUNCT
cusj-7788	120	11	proteins	protein	NOUN
cusj-7788	120	12	that	that	PRON
cusj-7788	120	13	present	present	ADJ
cusj-7788	120	14	peptides	peptide	NOUN
cusj-7788	120	15	to	to	PART
cusj-7788	120	16	ctls	ctls	VERB
cusj-7788	120	17	,	,	PUNCT
cusj-7788	120	18	thereby	thereby	ADV
cusj-7788	120	19	allowing	allow	VERB
cusj-7788	120	20	recognition	recognition	NOUN
cusj-7788	120	21	of	of	ADP
cusj-7788	120	22	infected	infected	ADJ
cusj-7788	120	23	cells	cell	NOUN
cusj-7788	120	24	[	[	X
cusj-7788	120	25	10	10	NUM
cusj-7788	120	26	,	,	PUNCT
cusj-7788	120	27	13	13	NUM
cusj-7788	120	28	]	]	PUNCT
cusj-7788	120	29	.	.	PUNCT
cusj-7788	121	1	in	in	ADP
cusj-7788	121	2	a	a	DET
cusj-7788	121	3	study	study	NOUN
cusj-7788	121	4	by	by	ADP
cusj-7788	121	5	grant	grant	NOUN
cusj-7788	121	6	and	and	CCONJ
cusj-7788	121	7	larijani	larijani	NOUN
cusj-7788	121	8	,	,	PUNCT
cusj-7788	121	9	it	it	PRON
cusj-7788	121	10	was	be	AUX
cusj-7788	121	11	found	find	VERB
cusj-7788	121	12	that	that	SCONJ
cusj-7788	121	13	a3g	a3g	PROPN
cusj-7788	121	14	/	/	SYM
cusj-7788	121	15	a3f	a3f	PROPN
cusj-7788	121	16	could	could	AUX
cusj-7788	121	17	cause	cause	VERB
cusj-7788	121	18	mutations	mutation	NOUN
cusj-7788	121	19	in	in	ADP
cusj-7788	121	20	hiv	hiv	PROPN
cusj-7788	121	21	peptides	peptide	NOUN
cusj-7788	121	22	that	that	PRON
cusj-7788	121	23	prevented	prevent	VERB
cusj-7788	121	24	the	the	DET
cusj-7788	121	25	virus	virus	NOUN
cusj-7788	121	26	from	from	ADP
cusj-7788	121	27	being	be	AUX
cusj-7788	121	28	detected	detect	VERB
cusj-7788	121	29	by	by	ADP
cusj-7788	121	30	ctls	ctls	PROPN
cusj-7788	121	31	,	,	PUNCT
cusj-7788	121	32	hence	hence	ADV
cusj-7788	121	33	enabling	enable	VERB
cusj-7788	121	34	it	it	PRON
cusj-7788	121	35	to	to	PART
cusj-7788	121	36	escape	escape	VERB
cusj-7788	121	37	the	the	DET
cusj-7788	121	38	host	host	NOUN
cusj-7788	121	39	cell	cell	NOUN
cusj-7788	121	40	’s	’s	PART
cusj-7788	121	41	immune	immune	ADJ
cusj-7788	121	42	response	response	NOUN
cusj-7788	121	43	[	[	X
cusj-7788	121	44	13	13	NUM
cusj-7788	121	45	]	]	PUNCT
cusj-7788	121	46	.	.	PUNCT
cusj-7788	122	1	similarly	similarly	ADV
cusj-7788	122	2	,	,	PUNCT
cusj-7788	122	3	a	a	DET
cusj-7788	122	4	study	study	NOUN
cusj-7788	122	5	by	by	ADP
cusj-7788	122	6	borzooee	borzooee	NOUN
cusj-7788	122	7	et	et	PROPN
cusj-7788	122	8	al	al	PROPN
cusj-7788	122	9	.	.	PROPN
cusj-7788	122	10	showed	show	VERB
cusj-7788	122	11	that	that	SCONJ
cusj-7788	122	12	a3g	a3g	PROPN
cusj-7788	122	13	-	-	PUNCT
cusj-7788	122	14	dependent	dependent	ADJ
cusj-7788	122	15	mutations	mutation	NOUN
cusj-7788	122	16	could	could	AUX
cusj-7788	122	17	lead	lead	VERB
cusj-7788	122	18	to	to	ADP
cusj-7788	122	19	decreased	decrease	VERB
cusj-7788	122	20	binding	bind	VERB
cusj-7788	122	21	affinity	affinity	NOUN
cusj-7788	122	22	of	of	ADP
cusj-7788	122	23	hla	hla	NOUN
cusj-7788	122	24	to	to	ADP
cusj-7788	122	25	the	the	DET
cusj-7788	122	26	peptide	peptide	NOUN
cusj-7788	122	27	epitopes	epitope	NOUN
cusj-7788	122	28	,	,	PUNCT
cusj-7788	122	29	which	which	PRON
cusj-7788	122	30	also	also	ADV
cusj-7788	122	31	enables	enable	VERB
cusj-7788	122	32	viral	viral	ADJ
cusj-7788	122	33	immune	immune	ADJ
cusj-7788	122	34	escape	escape	NOUN
cusj-7788	122	35	[	[	X
cusj-7788	122	36	10	10	NUM
cusj-7788	122	37	]	]	PUNCT
cusj-7788	122	38	.	.	PUNCT
cusj-7788	123	1	in	in	ADP
cusj-7788	123	2	this	this	DET
cusj-7788	123	3	study	study	NOUN
cusj-7788	123	4	,	,	PUNCT
cusj-7788	123	5	it	it	PRON
cusj-7788	123	6	was	be	AUX
cusj-7788	123	7	observed	observe	VERB
cusj-7788	123	8	that	that	SCONJ
cusj-7788	123	9	the	the	DET
cusj-7788	123	10	sequences	sequence	NOUN
cusj-7788	123	11	that	that	PRON
cusj-7788	123	12	encode	encode	VERB
cusj-7788	123	13	ctl	ctl	PROPN
cusj-7788	123	14	epitopes	epitope	NOUN
cusj-7788	123	15	in	in	ADP
cusj-7788	123	16	hiv	hiv	PROPN
cusj-7788	123	17	are	be	AUX
cusj-7788	123	18	rich	rich	ADJ
cusj-7788	123	19	in	in	ADP
cusj-7788	123	20	a3g	a3g	PROPN
cusj-7788	123	21	-	-	PUNCT
cusj-7788	123	22	preferred	prefer	VERB
cusj-7788	123	23	deamination	deamination	NOUN
cusj-7788	123	24	motifs	motif	NOUN
cusj-7788	123	25	,	,	PUNCT
cusj-7788	123	26	which	which	PRON
cusj-7788	123	27	preferentially	preferentially	ADV
cusj-7788	123	28	mutate	mutate	VERB
cusj-7788	123	29	the	the	DET
cusj-7788	123	30	c	c	PROPN
cusj-7788	123	31	in	in	ADP
cusj-7788	123	32	ccc	ccc	PROPN
cusj-7788	123	33	,	,	PUNCT
cusj-7788	123	34	tcc	tcc	PROPN
cusj-7788	123	35	,	,	PUNCT
cusj-7788	123	36	and	and	CCONJ
cusj-7788	123	37	acc	acc	PROPN
cusj-7788	124	1	[	[	X
cusj-7788	124	2	10	10	NUM
cusj-7788	124	3	]	]	PUNCT
cusj-7788	124	4	.	.	PUNCT
cusj-7788	125	1	this	this	PRON
cusj-7788	125	2	could	could	AUX
cusj-7788	125	3	result	result	VERB
cusj-7788	125	4	in	in	ADP
cusj-7788	125	5	missense	missense	NOUN
cusj-7788	125	6	mutations	mutation	NOUN
cusj-7788	125	7	that	that	PRON
cusj-7788	125	8	alter	alter	VERB
cusj-7788	125	9	ctl	ctl	PROPN
cusj-7788	125	10	epitopes	epitope	NOUN
cusj-7788	125	11	.	.	PUNCT
cusj-7788	126	1	thus	thus	ADV
cusj-7788	126	2	,	,	PUNCT
cusj-7788	126	3	these	these	DET
cusj-7788	126	4	mutations	mutation	NOUN
cusj-7788	126	5	could	could	AUX
cusj-7788	126	6	help	help	VERB
cusj-7788	126	7	the	the	DET
cusj-7788	126	8	virus	virus	NOUN
cusj-7788	126	9	evade	evade	VERB
cusj-7788	126	10	detection	detection	NOUN
cusj-7788	126	11	by	by	ADP
cusj-7788	126	12	the	the	DET
cusj-7788	126	13	host	host	NOUN
cusj-7788	126	14	cell	cell	NOUN
cusj-7788	126	15	's	's	PART
cusj-7788	126	16	immune	immune	ADJ
cusj-7788	126	17	response	response	NOUN
cusj-7788	126	18	,	,	PUNCT
cusj-7788	126	19	which	which	PRON
cusj-7788	126	20	enables	enable	VERB
cusj-7788	126	21	it	it	PRON
cusj-7788	126	22	to	to	PART
cusj-7788	126	23	continue	continue	VERB
cusj-7788	126	24	to	to	PART
cusj-7788	126	25	spread	spread	VERB
cusj-7788	126	26	in	in	ADP
cusj-7788	126	27	an	an	DET
cusj-7788	126	28	individual	individual	NOUN
cusj-7788	126	29	.	.	PUNCT
cusj-7788	127	1	these	these	DET
cusj-7788	127	2	studies	study	NOUN
cusj-7788	127	3	show	show	VERB
cusj-7788	127	4	that	that	SCONJ
cusj-7788	127	5	although	although	SCONJ
cusj-7788	127	6	a3	a3	NOUN
cusj-7788	127	7	g	g	PROPN
cusj-7788	127	8	could	could	AUX
cusj-7788	127	9	result	result	VERB
cusj-7788	127	10	in	in	ADP
cusj-7788	127	11	lethal	lethal	ADJ
cusj-7788	127	12	mutations	mutation	NOUN
cusj-7788	127	13	in	in	ADP
cusj-7788	127	14	the	the	DET
cusj-7788	127	15	virus	virus	NOUN
cusj-7788	127	16	,	,	PUNCT
cusj-7788	127	17	sublethal	sublethal	NOUN
cusj-7788	127	18	mutations	mutation	NOUN
cusj-7788	127	19	could	could	AUX
cusj-7788	127	20	cause	cause	VERB
cusj-7788	127	21	viral	viral	ADJ
cusj-7788	127	22	immune	immune	ADJ
cusj-7788	127	23	escape	escape	NOUN
cusj-7788	127	24	,	,	PUNCT
cusj-7788	127	25	where	where	SCONJ
cusj-7788	127	26	ctls	ctls	PROPN
cusj-7788	127	27	are	be	AUX
cusj-7788	127	28	no	no	ADV
cusj-7788	127	29	longer	long	ADV
cusj-7788	127	30	able	able	ADJ
cusj-7788	127	31	to	to	PART
cusj-7788	127	32	recognize	recognize	VERB
cusj-7788	127	33	infected	infected	ADJ
cusj-7788	127	34	cells	cell	NOUN
cusj-7788	127	35	to	to	PART
cusj-7788	127	36	target	target	VERB
cusj-7788	127	37	them	they	PRON
cusj-7788	127	38	for	for	ADP
cusj-7788	127	39	killing	kill	VERB
cusj-7788	127	40	.	.	PUNCT
cusj-7788	128	1	this	this	PRON
cusj-7788	128	2	could	could	AUX
cusj-7788	128	3	lead	lead	VERB
cusj-7788	128	4	to	to	ADP
cusj-7788	128	5	natural	natural	ADJ
cusj-7788	128	6	selection	selection	NOUN
cusj-7788	128	7	and	and	CCONJ
cusj-7788	128	8	viral	viral	ADJ
cusj-7788	128	9	evolution	evolution	NOUN
cusj-7788	128	10	,	,	PUNCT
cusj-7788	128	11	where	where	SCONJ
cusj-7788	128	12	the	the	DET
cusj-7788	128	13	viruses	virus	NOUN
cusj-7788	128	14	are	be	AUX
cusj-7788	128	15	able	able	ADJ
cusj-7788	128	16	to	to	PART
cusj-7788	128	17	acquire	acquire	VERB
cusj-7788	128	18	beneficial	beneficial	ADJ
cusj-7788	128	19	mutations	mutation	NOUN
cusj-7788	128	20	that	that	PRON
cusj-7788	128	21	enable	enable	VERB
cusj-7788	128	22	them	they	PRON
cusj-7788	128	23	to	to	PART
cusj-7788	128	24	become	become	VERB
cusj-7788	128	25	more	more	ADV
cusj-7788	128	26	fit	fit	ADJ
cusj-7788	128	27	and	and	CCONJ
cusj-7788	128	28	harmful	harmful	ADJ
cusj-7788	128	29	/	/	SYM
cusj-7788	128	30	difficult	difficult	ADJ
cusj-7788	128	31	to	to	PART
cusj-7788	128	32	treat	treat	VERB
cusj-7788	128	33	.	.	PUNCT
cusj-7788	129	1	conclusion	conclusion	NOUN
cusj-7788	129	2	in	in	ADP
cusj-7788	129	3	conclusion	conclusion	NOUN
cusj-7788	129	4	,	,	PUNCT
cusj-7788	129	5	many	many	ADJ
cusj-7788	129	6	studies	study	NOUN
cusj-7788	129	7	have	have	AUX
cusj-7788	129	8	shown	show	VERB
cusj-7788	129	9	the	the	DET
cusj-7788	129	10	effects	effect	NOUN
cusj-7788	129	11	of	of	ADP
cusj-7788	129	12	the	the	DET
cusj-7788	129	13	cytidine	cytidine	NOUN
cusj-7788	129	14	deaminase	deaminase	NOUN
cusj-7788	129	15	activity	activity	NOUN
cusj-7788	129	16	of	of	ADP
cusj-7788	129	17	the	the	DET
cusj-7788	129	18	a3	a3	NOUN
cusj-7788	129	19	genes	gene	NOUN
cusj-7788	129	20	on	on	ADP
cusj-7788	129	21	retroviral	retroviral	ADJ
cusj-7788	129	22	evolution	evolution	NOUN
cusj-7788	129	23	.	.	PUNCT
cusj-7788	130	1	apobec3	apobec3	ADJ
cusj-7788	130	2	proteins	protein	NOUN
cusj-7788	130	3	are	be	AUX
cusj-7788	130	4	known	know	VERB
cusj-7788	130	5	to	to	PART
cusj-7788	130	6	inhibit	inhibit	VERB
cusj-7788	130	7	viral	viral	ADJ
cusj-7788	130	8	infection	infection	NOUN
cusj-7788	130	9	through	through	ADP
cusj-7788	130	10	their	their	PRON
cusj-7788	130	11	cytidine	cytidine	NOUN
cusj-7788	130	12	deaminase	deaminase	NOUN
cusj-7788	130	13	activity	activity	NOUN
cusj-7788	131	1	[	[	X
cusj-7788	131	2	1	1	NUM
cusj-7788	131	3	,	,	PUNCT
cusj-7788	131	4	2	2	NUM
cusj-7788	131	5	,	,	PUNCT
cusj-7788	131	6	3	3	NUM
cusj-7788	131	7	,	,	PUNCT
cusj-7788	131	8	14	14	NUM
cusj-7788	131	9	]	]	PUNCT
cusj-7788	131	10	.	.	PUNCT
cusj-7788	132	1	however	however	ADV
cusj-7788	132	2	,	,	PUNCT
cusj-7788	132	3	lower	low	ADJ
cusj-7788	132	4	expression	expression	NOUN
cusj-7788	132	5	of	of	ADP
cusj-7788	132	6	a3	a3	NOUN
cusj-7788	132	7	proteins	protein	NOUN
cusj-7788	132	8	in	in	ADP
cusj-7788	132	9	cells	cell	NOUN
cusj-7788	132	10	could	could	AUX
cusj-7788	132	11	also	also	ADV
cusj-7788	132	12	lead	lead	VERB
cusj-7788	132	13	to	to	ADP
cusj-7788	132	14	viral	viral	ADJ
cusj-7788	132	15	evolution	evolution	NOUN
cusj-7788	132	16	[	[	X
cusj-7788	132	17	3	3	NUM
cusj-7788	132	18	,	,	PUNCT
cusj-7788	132	19	5	5	NUM
cusj-7788	132	20	,	,	PUNCT
cusj-7788	132	21	6	6	NUM
cusj-7788	132	22	]	]	PUNCT
cusj-7788	132	23	.	.	PUNCT
cusj-7788	133	1	when	when	SCONJ
cusj-7788	133	2	a3	a3	NOUN
cusj-7788	133	3	proteins	protein	NOUN
cusj-7788	133	4	such	such	ADJ
cusj-7788	133	5	as	as	ADP
cusj-7788	133	6	a3	a3	NOUN
cusj-7788	133	7	g	g	PROPN
cusj-7788	133	8	and	and	CCONJ
cusj-7788	133	9	a3f	a3f	PROPN
cusj-7788	133	10	are	be	AUX
cusj-7788	133	11	expressed	express	VERB
cusj-7788	133	12	at	at	ADP
cusj-7788	133	13	lower	low	ADJ
cusj-7788	133	14	levels	level	NOUN
cusj-7788	133	15	,	,	PUNCT
cusj-7788	133	16	they	they	PRON
cusj-7788	133	17	are	be	AUX
cusj-7788	133	18	likely	likely	ADJ
cusj-7788	133	19	to	to	PART
cusj-7788	133	20	introduce	introduce	VERB
cusj-7788	133	21	missense	missense	NOUN
cusj-7788	133	22	mutations	mutation	NOUN
cusj-7788	133	23	in	in	ADP
cusj-7788	133	24	the	the	DET
cusj-7788	133	25	virus	virus	NOUN
cusj-7788	133	26	,	,	PUNCT
cusj-7788	133	27	which	which	PRON
cusj-7788	133	28	instead	instead	ADV
cusj-7788	133	29	of	of	ADP
cusj-7788	133	30	inhibiting	inhibit	VERB
cusj-7788	133	31	the	the	DET
cusj-7788	133	32	virus	virus	NOUN
cusj-7788	133	33	,	,	PUNCT
cusj-7788	133	34	helps	help	VERB
cusj-7788	133	35	it	it	PRON
cusj-7788	133	36	obcolumbia	obcolumbia	ADJ
cusj-7788	133	37	undergraduate	undergraduate	PROPN
cusj-7788	133	38	science	science	PROPN
cusj-7788	133	39	journal	journal	PROPN
cusj-7788	133	40	vol	vol	NOUN
cusj-7788	133	41	.	.	PROPN
cusj-7788	133	42	15	15	NUM
cusj-7788	133	43	,	,	PUNCT
cusj-7788	133	44	2021	2021	NUM
cusj-7788	133	45	obikili	obikili	NOUN
cusj-7788	133	46	.	.	PUNCT
cusj-7788	134	1	60	60	NUM
cusj-7788	134	2	tain	tain	NOUN
cusj-7788	134	3	beneficial	beneficial	ADJ
cusj-7788	134	4	mutations	mutation	NOUN
cusj-7788	134	5	that	that	PRON
cusj-7788	134	6	allow	allow	VERB
cusj-7788	134	7	it	it	PRON
cusj-7788	134	8	to	to	PART
cusj-7788	134	9	become	become	VERB
cusj-7788	134	10	more	more	ADV
cusj-7788	134	11	fit	fit	ADJ
cusj-7788	134	12	and	and	CCONJ
cusj-7788	134	13	able	able	ADJ
cusj-7788	134	14	to	to	PART
cusj-7788	134	15	evade	evade	VERB
cusj-7788	134	16	the	the	DET
cusj-7788	134	17	cells	cell	NOUN
cusj-7788	134	18	’	’	PART
cusj-7788	134	19	immune	immune	ADJ
cusj-7788	134	20	response	response	NOUN
cusj-7788	134	21	[	[	X
cusj-7788	134	22	10	10	NUM
cusj-7788	134	23	,	,	PUNCT
cusj-7788	134	24	13	13	NUM
cusj-7788	134	25	]	]	PUNCT
cusj-7788	134	26	and	and	CCONJ
cusj-7788	134	27	develop	develop	VERB
cusj-7788	134	28	drug	drug	NOUN
cusj-7788	134	29	resistance	resistance	NOUN
cusj-7788	135	1	[	[	X
cusj-7788	135	2	6	6	NUM
cusj-7788	135	3	,	,	PUNCT
cusj-7788	135	4	11	11	NUM
cusj-7788	135	5	,	,	PUNCT
cusj-7788	135	6	12	12	NUM
cusj-7788	135	7	]	]	PUNCT
cusj-7788	135	8	.	.	PUNCT
cusj-7788	136	1	also	also	ADV
cusj-7788	136	2	,	,	PUNCT
cusj-7788	136	3	many	many	ADJ
cusj-7788	136	4	studies	study	NOUN
cusj-7788	136	5	show	show	VERB
cusj-7788	136	6	that	that	SCONJ
cusj-7788	136	7	hiv	hiv	PROPN
cusj-7788	136	8	can	can	AUX
cusj-7788	136	9	evolve	evolve	VERB
cusj-7788	136	10	to	to	PART
cusj-7788	136	11	overcome	overcome	VERB
cusj-7788	136	12	a3	a3	NOUN
cusj-7788	136	13	’s	’s	PART
cusj-7788	136	14	cytidine	cytidine	NOUN
cusj-7788	136	15	deaminase	deaminase	NOUN
cusj-7788	136	16	activity	activity	NOUN
cusj-7788	136	17	by	by	ADP
cusj-7788	136	18	encoding	encode	VERB
cusj-7788	136	19	vif	vif	PROPN
cusj-7788	136	20	's	's	PART
cusj-7788	136	21	variants	variant	NOUN
cusj-7788	136	22	that	that	SCONJ
cusj-7788	136	23	more	more	ADV
cusj-7788	136	24	effectively	effectively	ADV
cusj-7788	136	25	target	target	NOUN
cusj-7788	136	26	a3	a3	NOUN
cusj-7788	136	27	for	for	ADP
cusj-7788	136	28	proteasomal	proteasomal	ADJ
cusj-7788	136	29	degradation	degradation	NOUN
cusj-7788	136	30	[	[	X
cusj-7788	136	31	1	1	NUM
cusj-7788	136	32	,	,	PUNCT
cusj-7788	136	33	3	3	NUM
cusj-7788	136	34	,	,	PUNCT
cusj-7788	136	35	5	5	NUM
cusj-7788	136	36	,	,	PUNCT
cusj-7788	136	37	14	14	NUM
cusj-7788	136	38	]	]	PUNCT
cusj-7788	136	39	.	.	PUNCT
cusj-7788	137	1	moreover	moreover	ADV
cusj-7788	137	2	,	,	PUNCT
cusj-7788	137	3	fourati	fourati	PROPN
cusj-7788	137	4	et	et	PROPN
cusj-7788	137	5	al	al	PROPN
cusj-7788	137	6	.	.	PROPN
cusj-7788	137	7	and	and	CCONJ
cusj-7788	137	8	mulder	mulder	PROPN
cusj-7788	137	9	et	et	PROPN
cusj-7788	137	10	al	al	PROPN
cusj-7788	137	11	.	.	PROPN
cusj-7788	137	12	,	,	PUNCT
cusj-7788	137	13	both	both	PRON
cusj-7788	137	14	showed	show	VERB
cusj-7788	137	15	that	that	SCONJ
cusj-7788	137	16	in	in	ADP
cusj-7788	137	17	addition	addition	NOUN
cusj-7788	137	18	to	to	ADP
cusj-7788	137	19	a3	a3	NOUN
cusj-7788	137	20	-	-	PUNCT
cusj-7788	137	21	dependent	dependent	ADJ
cusj-7788	137	22	mutations	mutation	NOUN
cusj-7788	137	23	,	,	PUNCT
cusj-7788	137	24	viruses	virus	NOUN
cusj-7788	137	25	could	could	AUX
cusj-7788	137	26	also	also	ADV
cusj-7788	137	27	evolve	evolve	VERB
cusj-7788	137	28	via	via	ADP
cusj-7788	137	29	recombination	recombination	NOUN
cusj-7788	137	30	,	,	PUNCT
cusj-7788	137	31	where	where	SCONJ
cusj-7788	137	32	defective	defective	ADJ
cusj-7788	137	33	viruses	virus	NOUN
cusj-7788	137	34	after	after	SCONJ
cusj-7788	137	35	recombination	recombination	NOUN
cusj-7788	137	36	gain	gain	NOUN
cusj-7788	137	37	drug	drug	NOUN
cusj-7788	137	38	resistance	resistance	NOUN
cusj-7788	138	1	[	[	X
cusj-7788	138	2	6	6	NUM
cusj-7788	138	3	,	,	PUNCT
cusj-7788	138	4	11	11	NUM
cusj-7788	138	5	]	]	PUNCT
cusj-7788	138	6	.	.	PUNCT
cusj-7788	139	1	these	these	DET
cusj-7788	139	2	studies	study	NOUN
cusj-7788	139	3	collectively	collectively	ADV
cusj-7788	139	4	suggest	suggest	VERB
cusj-7788	139	5	that	that	SCONJ
cusj-7788	139	6	a3	a3	NOUN
cusj-7788	139	7	proteins	protein	NOUN
cusj-7788	139	8	play	play	VERB
cusj-7788	139	9	an	an	DET
cusj-7788	139	10	important	important	ADJ
cusj-7788	139	11	role	role	NOUN
cusj-7788	139	12	in	in	ADP
cusj-7788	139	13	the	the	DET
cusj-7788	139	14	host	host	NOUN
cusj-7788	139	15	cells	cell	NOUN
cusj-7788	139	16	’	’	PART
cusj-7788	139	17	immune	immune	ADJ
cusj-7788	139	18	response	response	NOUN
cusj-7788	139	19	and	and	CCONJ
cusj-7788	139	20	help	help	VERB
cusj-7788	139	21	the	the	DET
cusj-7788	139	22	cells	cell	NOUN
cusj-7788	139	23	to	to	PART
cusj-7788	139	24	combat	combat	VERB
cusj-7788	139	25	viral	viral	ADJ
cusj-7788	139	26	infection	infection	NOUN
cusj-7788	139	27	.	.	PUNCT
cusj-7788	140	1	although	although	SCONJ
cusj-7788	140	2	,	,	PUNCT
cusj-7788	140	3	these	these	DET
cusj-7788	140	4	studies	study	NOUN
cusj-7788	140	5	highlight	highlight	VERB
cusj-7788	140	6	the	the	DET
cusj-7788	140	7	importance	importance	NOUN
cusj-7788	140	8	of	of	ADP
cusj-7788	140	9	a3	a3	NOUN
cusj-7788	140	10	proteins	protein	NOUN
cusj-7788	140	11	,	,	PUNCT
cusj-7788	140	12	they	they	PRON
cusj-7788	140	13	also	also	ADV
cusj-7788	140	14	show	show	VERB
cusj-7788	140	15	the	the	DET
cusj-7788	140	16	limitations	limitation	NOUN
cusj-7788	140	17	of	of	ADP
cusj-7788	140	18	its	its	PRON
cusj-7788	140	19	use	use	NOUN
cusj-7788	140	20	in	in	ADP
cusj-7788	140	21	preventing	prevent	VERB
cusj-7788	140	22	viral	viral	ADJ
cusj-7788	140	23	infection	infection	NOUN
cusj-7788	140	24	,	,	PUNCT
cusj-7788	140	25	since	since	SCONJ
cusj-7788	140	26	hiv-1	hiv-1	ADJ
cusj-7788	140	27	vif	vif	NOUN
cusj-7788	140	28	protein	protein	NOUN
cusj-7788	140	29	inhibits	inhibit	VERB
cusj-7788	140	30	a3	a3	NOUN
cusj-7788	140	31	proteins	protein	NOUN
cusj-7788	140	32	’	'	PUNCT
cusj-7788	140	33	antiviral	antiviral	ADJ
cusj-7788	140	34	activity	activity	NOUN
cusj-7788	140	35	.	.	PUNCT
cusj-7788	141	1	future	future	ADJ
cusj-7788	141	2	studies	study	NOUN
cusj-7788	141	3	should	should	AUX
cusj-7788	141	4	focus	focus	VERB
cusj-7788	141	5	on	on	ADP
cusj-7788	141	6	developing	develop	VERB
cusj-7788	141	7	drugs	drug	NOUN
cusj-7788	141	8	that	that	PRON
cusj-7788	141	9	would	would	AUX
cusj-7788	141	10	inhibit	inhibit	VERB
cusj-7788	141	11	hiv-1	hiv-1	PUNCT
cusj-7788	141	12	vif	vif	PROPN
cusj-7788	141	13	’s	’s	PART
cusj-7788	141	14	ability	ability	NOUN
cusj-7788	141	15	to	to	PART
cusj-7788	141	16	bind	bind	VERB
cusj-7788	141	17	and	and	CCONJ
cusj-7788	141	18	degrade	degrade	VERB
cusj-7788	141	19	a3	a3	NOUN
cusj-7788	141	20	proteins	protein	NOUN
cusj-7788	141	21	,	,	PUNCT
cusj-7788	141	22	or	or	CCONJ
cusj-7788	141	23	enable	enable	VERB
cusj-7788	141	24	a3	a3	NOUN
cusj-7788	141	25	proteins	protein	NOUN
cusj-7788	141	26	,	,	PUNCT
cusj-7788	141	27	specifically	specifically	ADV
cusj-7788	141	28	a3	a3	VERB
cusj-7788	141	29	g	g	NOUN
cusj-7788	141	30	,	,	PUNCT
cusj-7788	141	31	to	to	PART
cusj-7788	141	32	overcome	overcome	VERB
cusj-7788	141	33	vif	vif	NOUN
cusj-7788	141	34	activity	activity	NOUN
cusj-7788	141	35	,	,	PUNCT
cusj-7788	141	36	so	so	SCONJ
cusj-7788	141	37	that	that	SCONJ
cusj-7788	141	38	they	they	PRON
cusj-7788	141	39	could	could	AUX
cusj-7788	141	40	better	well	ADV
cusj-7788	141	41	inhibit	inhibit	VERB
cusj-7788	141	42	retroviral	retroviral	ADJ
cusj-7788	141	43	infection	infection	NOUN
cusj-7788	141	44	and	and	CCONJ
cusj-7788	141	45	evolution	evolution	NOUN
cusj-7788	141	46	.	.	PUNCT
cusj-7788	142	1	author	author	NOUN
cusj-7788	142	2	information	information	NOUN
cusj-7788	142	3	corresponding	correspond	VERB
cusj-7788	142	4	author	author	NOUN
cusj-7788	142	5	*	*	PUNCT
cusj-7788	142	6	mary	mary	PROPN
cusj-7788	142	7	-	-	PUNCT
cusj-7788	142	8	benedicta	benedicta	PROPN
cusj-7788	142	9	obikili	obikili	NOUN
cusj-7788	142	10	mobiki2@uic.edu	mobiki2@uic.edu	PROPN
cusj-7788	142	11	funding	funding	NOUN
cusj-7788	142	12	sources	source	NOUN
cusj-7788	142	13	this	this	DET
cusj-7788	142	14	research	research	NOUN
cusj-7788	142	15	was	be	AUX
cusj-7788	142	16	supported	support	VERB
cusj-7788	142	17	by	by	ADP
cusj-7788	142	18	the	the	DET
cusj-7788	142	19	nih	nih	PROPN
cusj-7788	142	20	/	/	SYM
cusj-7788	142	21	niaid	niaid	PROPN
cusj-7788	142	22	grant	grant	PROPN
cusj-7788	142	23	r01ai085015	r01ai085015	PROPN
cusj-7788	142	24	and	and	CCONJ
cusj-7788	142	25	the	the	DET
cusj-7788	142	26	l@s	l@s	PROPN
cusj-7788	142	27	ganas	ganas	PROPN
cusj-7788	142	28	project	project	NOUN
cusj-7788	142	29	(	(	PUNCT
cusj-7788	142	30	hsi	hsi	PROPN
cusj-7788	142	31	stem	stem	NOUN
cusj-7788	142	32	grant	grant	NOUN
cusj-7788	142	33	from	from	ADP
cusj-7788	142	34	dept	dept	PROPN
cusj-7788	142	35	.	.	PROPN
cusj-7788	142	36	of	of	ADP
cusj-7788	142	37	education	education	PROPN
cusj-7788	142	38	p031c160237	p031c160237	PUNCT
cusj-7788	142	39	)	)	PUNCT
cusj-7788	142	40	.	.	PUNCT
cusj-7788	143	1	competing	compete	VERB
cusj-7788	143	2	interests	interest	NOUN
cusj-7788	143	3	the	the	DET
cusj-7788	143	4	author	author	NOUN
cusj-7788	143	5	declares	declare	VERB
cusj-7788	143	6	no	no	DET
cusj-7788	143	7	competing	compete	VERB
cusj-7788	143	8	financial	financial	ADJ
cusj-7788	143	9	and	and	CCONJ
cusj-7788	143	10	non	non	ADJ
cusj-7788	143	11	-	-	ADJ
cusj-7788	143	12	financial	financial	ADJ
cusj-7788	143	13	interests	interest	NOUN
cusj-7788	143	14	.	.	PUNCT
cusj-7788	144	1	acknowledgments	acknowledgment	NOUN
cusj-7788	144	2	i	i	PRON
cusj-7788	144	3	would	would	AUX
cusj-7788	144	4	like	like	VERB
cusj-7788	144	5	to	to	PART
cusj-7788	144	6	thank	thank	VERB
cusj-7788	144	7	l@s	l@s	PROPN
cusj-7788	144	8	ganas	ganas	PROPN
cusj-7788	144	9	research	research	NOUN
cusj-7788	144	10	fellowship	fellowship	NOUN
cusj-7788	144	11	and	and	CCONJ
cusj-7788	144	12	the	the	DET
cusj-7788	144	13	chancellor	chancellor	NOUN
cusj-7788	144	14	’s	’s	PART
cusj-7788	144	15	undergraduate	undergraduate	PROPN
cusj-7788	144	16	research	research	NOUN
cusj-7788	144	17	award	award	PROPN
cusj-7788	144	18	(	(	PUNCT
cusj-7788	144	19	cura	cura	PROPN
cusj-7788	144	20	)	)	PUNCT
cusj-7788	144	21	for	for	ADP
cusj-7788	144	22	funding	fund	VERB
cusj-7788	144	23	my	my	PRON
cusj-7788	144	24	research	research	NOUN
cusj-7788	144	25	.	.	PUNCT
cusj-7788	145	1	i	i	PRON
cusj-7788	145	2	would	would	AUX
cusj-7788	145	3	also	also	ADV
cusj-7788	145	4	like	like	VERB
cusj-7788	145	5	to	to	PART
cusj-7788	145	6	thank	thank	VERB
cusj-7788	145	7	the	the	DET
cusj-7788	145	8	entire	entire	ADJ
cusj-7788	145	9	ross	ross	NOUN
cusj-7788	145	10	lab	lab	NOUN
cusj-7788	145	11	,	,	PUNCT
cusj-7788	145	12	for	for	ADP
cusj-7788	145	13	their	their	PRON
cusj-7788	145	14	support	support	NOUN
cusj-7788	145	15	during	during	ADP
cusj-7788	145	16	my	my	PRON
cusj-7788	145	17	research	research	NOUN
cusj-7788	145	18	.	.	PUNCT
cusj-7788	146	1	i	i	PRON
cusj-7788	146	2	especially	especially	ADV
cusj-7788	146	3	want	want	VERB
cusj-7788	146	4	to	to	PART
cusj-7788	146	5	thank	thank	VERB
cusj-7788	146	6	dr	dr	PROPN
cusj-7788	146	7	.	.	PROPN
cusj-7788	146	8	karen	karen	PROPN
cusj-7788	146	9	salas	salas	PROPN
cusj-7788	146	10	briceno	briceno	PROPN
cusj-7788	146	11	,	,	PUNCT
cusj-7788	146	12	for	for	ADP
cusj-7788	146	13	all	all	DET
cusj-7788	146	14	her	her	PRON
cusj-7788	146	15	mentorship	mentorship	NOUN
cusj-7788	146	16	and	and	CCONJ
cusj-7788	146	17	guidance	guidance	NOUN
cusj-7788	146	18	during	during	ADP
cusj-7788	146	19	my	my	PRON
cusj-7788	146	20	research	research	NOUN
cusj-7788	146	21	.	.	PUNCT
cusj-7788	147	1	finally	finally	ADV
cusj-7788	147	2	,	,	PUNCT
cusj-7788	147	3	i	i	PRON
cusj-7788	147	4	am	be	AUX
cusj-7788	147	5	especially	especially	ADV
cusj-7788	147	6	grateful	grateful	ADJ
cusj-7788	147	7	to	to	ADP
cusj-7788	147	8	dr	dr	PROPN
cusj-7788	147	9	.	.	PROPN
cusj-7788	147	10	susan	susan	PROPN
cusj-7788	147	11	r.	r.	PROPN
cusj-7788	147	12	ross	ross	PROPN
cusj-7788	147	13	,	,	PUNCT
cusj-7788	147	14	who	who	PRON
cusj-7788	147	15	provided	provide	VERB
cusj-7788	147	16	me	i	PRON
cusj-7788	147	17	with	with	ADP
cusj-7788	147	18	immense	immense	ADJ
cusj-7788	147	19	knowledge	knowledge	NOUN
cusj-7788	147	20	and	and	CCONJ
cusj-7788	147	21	guidance	guidance	NOUN
cusj-7788	147	22	during	during	ADP
cusj-7788	147	23	my	my	PRON
cusj-7788	147	24	time	time	NOUN
cusj-7788	147	25	at	at	ADP
cusj-7788	147	26	her	her	PRON
cusj-7788	147	27	lab	lab	NOUN
cusj-7788	147	28	.	.	PUNCT
cusj-7788	148	1	i	i	PRON
cusj-7788	148	2	am	be	AUX
cusj-7788	148	3	truly	truly	ADV
cusj-7788	148	4	grateful	grateful	ADJ
cusj-7788	148	5	for	for	ADP
cusj-7788	148	6	the	the	DET
cusj-7788	148	7	opportunity	opportunity	NOUN
cusj-7788	148	8	of	of	ADP
cusj-7788	148	9	doing	do	VERB
cusj-7788	148	10	research	research	NOUN
cusj-7788	148	11	at	at	ADP
cusj-7788	148	12	the	the	DET
cusj-7788	148	13	ross	ross	PROPN
cusj-7788	148	14	lab	lab	PROPN
cusj-7788	148	15	.	.	PUNCT
cusj-7788	149	1	references	reference	NOUN
cusj-7788	149	2	[	[	X
cusj-7788	149	3	1	1	NUM
cusj-7788	149	4	]	]	PUNCT
cusj-7788	149	5	stavrou	stavrou	NOUN
cusj-7788	149	6	s	s	PROPN
cusj-7788	149	7	,	,	PUNCT
cusj-7788	149	8	ross	ross	PROPN
cusj-7788	149	9	sr	sr	PROPN
cusj-7788	149	10	(	(	PUNCT
cusj-7788	149	11	2015	2015	NUM
cusj-7788	149	12	)	)	PUNCT
cusj-7788	149	13	apobec3	apobec3	NOUN
cusj-7788	149	14	proteins	protein	NOUN
cusj-7788	149	15	in	in	ADP
cusj-7788	149	16	viral	viral	ADJ
cusj-7788	149	17	immunity	immunity	NOUN
cusj-7788	149	18	.	.	PUNCT
cusj-7788	150	1	the	the	DET
cusj-7788	150	2	journal	journal	NOUN
cusj-7788	150	3	of	of	ADP
cusj-7788	150	4	immunology	immunology	NOUN
cusj-7788	150	5	195(10):4565–4570	195(10):4565–4570	NUM
cusj-7788	150	6	.	.	PUNCT
cusj-7788	151	1	[	[	X
cusj-7788	151	2	2	2	X
cusj-7788	151	3	]	]	PUNCT
cusj-7788	151	4	armitage	armitage	PROPN
cusj-7788	151	5	ae	ae	PROPN
cusj-7788	151	6	,	,	PUNCT
cusj-7788	151	7	et	et	PROPN
cusj-7788	151	8	al	al	PROPN
cusj-7788	151	9	.	.	PUNCT
cusj-7788	151	10	(	(	PUNCT
cusj-7788	151	11	2014	2014	NUM
cusj-7788	151	12	)	)	PUNCT
cusj-7788	151	13	possible	possible	ADJ
cusj-7788	151	14	footprints	footprint	NOUN
cusj-7788	151	15	of	of	ADP
cusj-7788	151	16	apobec3f	apobec3f	PROPN
cusj-7788	151	17	and/or	and/or	CCONJ
cusj-7788	151	18	other	other	ADJ
cusj-7788	151	19	apobec3	apobec3	NOUN
cusj-7788	151	20	deaminases	deaminase	NOUN
cusj-7788	151	21	,	,	PUNCT
cusj-7788	151	22	but	but	CCONJ
cusj-7788	151	23	not	not	PART
cusj-7788	151	24	apobec3	apobec3	ADP
cusj-7788	151	25	g	g	NOUN
cusj-7788	151	26	,	,	PUNCT
cusj-7788	151	27	on	on	ADP
cusj-7788	151	28	hiv-1	hiv-1	X
cusj-7788	151	29	from	from	ADP
cusj-7788	151	30	patients	patient	NOUN
cusj-7788	151	31	with	with	ADP
cusj-7788	151	32	acute	acute	NOUN
cusj-7788	151	33	/	/	SYM
cusj-7788	151	34	early	early	ADJ
cusj-7788	151	35	and	and	CCONJ
cusj-7788	151	36	chronic	chronic	ADJ
cusj-7788	151	37	infections	infection	NOUN
cusj-7788	151	38	.	.	PUNCT
cusj-7788	152	1	journal	journal	PROPN
cusj-7788	152	2	of	of	ADP
cusj-7788	152	3	virology	virology	NOUN
cusj-7788	152	4	88(21):12882	88(21):12882	NUM
cusj-7788	152	5	–	–	PUNCT
cusj-7788	152	6	12894	12894	NUM
cusj-7788	152	7	.	.	PUNCT
cusj-7788	153	1	[	[	X
cusj-7788	153	2	3	3	X
cusj-7788	153	3	]	]	X
cusj-7788	153	4	kim	kim	PROPN
cusj-7788	153	5	e	e	PROPN
cusj-7788	153	6	-	-	PROPN
cusj-7788	153	7	y	y	PROPN
cusj-7788	153	8	,	,	PUNCT
cusj-7788	153	9	et	et	PROPN
cusj-7788	153	10	al	al	PROPN
cusj-7788	153	11	.	.	PUNCT
cusj-7788	153	12	(	(	PUNCT
cusj-7788	153	13	2014	2014	NUM
cusj-7788	153	14	)	)	PUNCT
cusj-7788	153	15	human	human	ADJ
cusj-7788	153	16	apobec3	apobec3	NOUN
cusj-7788	153	17	induced	induce	VERB
cusj-7788	153	18	mutation	mutation	NOUN
cusj-7788	153	19	of	of	ADP
cusj-7788	153	20	human	human	ADJ
cusj-7788	153	21	immunodeficiency	immunodeficiency	NOUN
cusj-7788	153	22	virus	virus	NOUN
cusj-7788	153	23	type-1	type-1	PRON
cusj-7788	153	24	contributes	contribute	VERB
cusj-7788	153	25	to	to	ADP
cusj-7788	153	26	adaptation	adaptation	NOUN
cusj-7788	153	27	and	and	CCONJ
cusj-7788	153	28	evolution	evolution	NOUN
cusj-7788	153	29	in	in	ADP
cusj-7788	153	30	natural	natural	ADJ
cusj-7788	153	31	infection	infection	NOUN
cusj-7788	153	32	.	.	PUNCT
cusj-7788	154	1	plos	plos	PROPN
cusj-7788	154	2	pathogens	pathogen	NOUN
cusj-7788	154	3	10(7	10(7	NUM
cusj-7788	154	4	)	)	PUNCT
cusj-7788	154	5	.	.	PUNCT
cusj-7788	155	1	doi:10.1371	doi:10.1371	PROPN
cusj-7788	155	2	/	/	PUNCT
cusj-7788	156	1	journal.ppat.1004281	journal.ppat.1004281	PROPN
cusj-7788	156	2	.	.	PUNCT
cusj-7788	157	1	[	[	X
cusj-7788	157	2	4	4	X
cusj-7788	157	3	]	]	PUNCT
cusj-7788	157	4	sousa	sousa	PROPN
cusj-7788	157	5	mm	mm	PROPN
cusj-7788	157	6	,	,	PUNCT
cusj-7788	157	7	krokan	krokan	VERB
cusj-7788	157	8	he	he	PRON
cusj-7788	157	9	,	,	PUNCT
cusj-7788	157	10	slupphaug	slupphaug	PROPN
cusj-7788	157	11	g	g	PROPN
cusj-7788	157	12	(	(	PUNCT
cusj-7788	157	13	2007	2007	NUM
cusj-7788	157	14	)	)	PUNCT
cusj-7788	157	15	dna	dna	PROPN
cusj-7788	157	16	-	-	PUNCT
cusj-7788	157	17	uracil	uracil	ADJ
cusj-7788	157	18	and	and	CCONJ
cusj-7788	157	19	human	human	ADJ
cusj-7788	157	20	pathology	pathology	NOUN
cusj-7788	157	21	.	.	PUNCT
cusj-7788	158	1	molecular	molecular	ADJ
cusj-7788	158	2	aspects	aspect	NOUN
cusj-7788	158	3	of	of	ADP
cusj-7788	158	4	medicine	medicine	NOUN
cusj-7788	158	5	28(3	28(3	PROPN
cusj-7788	158	6	-	-	PUNCT
cusj-7788	158	7	4):276–306	4):276–306	NOUN
cusj-7788	158	8	.	.	PUNCT
cusj-7788	159	1	[	[	X
cusj-7788	159	2	5	5	NUM
cusj-7788	159	3	]	]	PUNCT
cusj-7788	159	4	sato	sato	PROPN
cusj-7788	159	5	k	k	PROPN
cusj-7788	159	6	,	,	PUNCT
cusj-7788	159	7	et	et	PROPN
cusj-7788	159	8	al	al	PROPN
cusj-7788	159	9	.	.	PUNCT
cusj-7788	159	10	(	(	PUNCT
cusj-7788	159	11	2014	2014	NUM
cusj-7788	159	12	)	)	PUNCT
cusj-7788	159	13	apobec3d	apobec3d	NOUN
cusj-7788	159	14	and	and	CCONJ
cusj-7788	159	15	apobec3f	apobec3f	PROPN
cusj-7788	159	16	potently	potently	ADV
cusj-7788	159	17	promote	promote	VERB
cusj-7788	159	18	hiv-1	hiv-1	ADJ
cusj-7788	159	19	diversification	diversification	NOUN
cusj-7788	159	20	and	and	CCONJ
cusj-7788	159	21	evolution	evolution	NOUN
cusj-7788	159	22	in	in	ADP
cusj-7788	159	23	humanized	humanize	VERB
cusj-7788	159	24	mouse	mouse	NOUN
cusj-7788	159	25	model	model	NOUN
cusj-7788	159	26	.	.	PUNCT
cusj-7788	160	1	plos	plos	PROPN
cusj-7788	160	2	pathogens	pathogen	NOUN
cusj-7788	160	3	10(10	10(10	NUM
cusj-7788	160	4	)	)	PUNCT
cusj-7788	160	5	.	.	PUNCT
cusj-7788	161	1	doi:10.1371	doi:10.1371	PROPN
cusj-7788	161	2	/	/	SYM
cusj-7788	161	3	journal	journal	NOUN
cusj-7788	161	4	.	.	PUNCT
cusj-7788	162	1	ppat.1004453	ppat.1004453	VERB
cusj-7788	162	2	.	.	PUNCT
cusj-7788	163	1	[	[	X
cusj-7788	163	2	6	6	NUM
cusj-7788	163	3	]	]	SYM
cusj-7788	163	4	fourati	fourati	PROPN
cusj-7788	163	5	s	s	PROPN
cusj-7788	163	6	,	,	PUNCT
cusj-7788	163	7	et	et	PROPN
cusj-7788	163	8	al	al	PROPN
cusj-7788	163	9	.	.	PUNCT
cusj-7788	164	1	(	(	PUNCT
cusj-7788	164	2	2014	2014	NUM
cusj-7788	164	3	)	)	PUNCT
cusj-7788	164	4	differential	differential	NOUN
cusj-7788	164	5	impact	impact	NOUN
cusj-7788	164	6	of	of	ADP
cusj-7788	164	7	apobec3	apobec3	ADV
cusj-7788	164	8	-	-	PUNCT
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cusj-7788	164	10	mutagenesis	mutagenesis	NOUN
cusj-7788	164	11	on	on	ADP
cusj-7788	164	12	hiv	hiv	PROPN
cusj-7788	164	13	evolution	evolution	NOUN
cusj-7788	164	14	in	in	ADP
cusj-7788	164	15	diverse	diverse	ADJ
cusj-7788	164	16	anatomical	anatomical	ADJ
cusj-7788	164	17	compartments	compartment	NOUN
cusj-7788	164	18	.	.	PUNCT
cusj-7788	165	1	aids	aids	PROPN
cusj-7788	165	2	28(4):487–491	28(4):487–491	PROPN
cusj-7788	165	3	.	.	PUNCT
cusj-7788	166	1	[	[	X
cusj-7788	166	2	7	7	NUM
cusj-7788	166	3	]	]	X
cusj-7788	166	4	parker	parker	PROPN
cusj-7788	166	5	n	n	CCONJ
cusj-7788	166	6	,	,	PUNCT
cusj-7788	166	7	schneegurt	schneegurt	PROPN
cusj-7788	166	8	m	m	PROPN
cusj-7788	166	9	,	,	PUNCT
cusj-7788	166	10	tu	tu	PROPN
cusj-7788	166	11	a	a	PROPN
cusj-7788	166	12	-	-	PUNCT
cusj-7788	166	13	ht	ht	PROPN
cusj-7788	166	14	,	,	PUNCT
cusj-7788	166	15	forster	forster	PROPN
cusj-7788	166	16	bm	bm	PROPN
cusj-7788	166	17	,	,	PUNCT
cusj-7788	166	18	lister	lister	PROPN
cusj-7788	166	19	p	p	PROPN
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cusj-7788	166	21	2016	2016	NUM
cusj-7788	166	22	)	)	PUNCT
cusj-7788	166	23	microbiology	microbiology	NOUN
cusj-7788	166	24	(	(	PUNCT
cusj-7788	166	25	openstax	openstax	PROPN
cusj-7788	166	26	,	,	PUNCT
cusj-7788	166	27	houston	houston	PROPN
cusj-7788	166	28	,	,	PUNCT
cusj-7788	166	29	tx	tx	PROPN
cusj-7788	166	30	)	)	PUNCT
cusj-7788	166	31	.	.	PUNCT
cusj-7788	167	1	columbia	columbia	PROPN
cusj-7788	167	2	undergraduate	undergraduate	PROPN
cusj-7788	167	3	science	science	PROPN
cusj-7788	167	4	journal	journal	PROPN
cusj-7788	167	5	vol	vol	NOUN
cusj-7788	167	6	.	.	PROPN
cusj-7788	167	7	15	15	NUM
cusj-7788	167	8	,	,	PUNCT
cusj-7788	167	9	2021	2021	NUM
cusj-7788	167	10	obikili	obikili	NOUN
cusj-7788	167	11	61	61	NUM
cusj-7788	168	1	[	[	SYM
cusj-7788	168	2	8	8	NUM
cusj-7788	168	3	]	]	X
cusj-7788	168	4	herron	herron	PROPN
cusj-7788	168	5	jc	jc	PROPN
cusj-7788	168	6	,	,	PUNCT
cusj-7788	168	7	freeman	freeman	PROPN
cusj-7788	168	8	s	s	PROPN
cusj-7788	168	9	(	(	PUNCT
cusj-7788	168	10	2014	2014	NUM
cusj-7788	168	11	)	)	PUNCT
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cusj-7788	168	13	analysis	analysis	NOUN
cusj-7788	168	14	(	(	PUNCT
cusj-7788	168	15	pearson	pearson	PROPN
cusj-7788	168	16	)	)	PUNCT
cusj-7788	168	17	.	.	PUNCT
cusj-7788	169	1	5th	5th	ADJ
cusj-7788	169	2	ed	ed	NOUN
cusj-7788	169	3	.	.	PUNCT
cusj-7788	170	1	[	[	X
cusj-7788	170	2	9	9	NUM
cusj-7788	170	3	]	]	PUNCT
cusj-7788	170	4	an	an	DET
cusj-7788	170	5	p	p	NOUN
cusj-7788	170	6	,	,	PUNCT
cusj-7788	170	7	et	et	PROPN
cusj-7788	170	8	al	al	PROPN
cusj-7788	170	9	.	.	PROPN
cusj-7788	170	10	(	(	PUNCT
cusj-7788	170	11	2004	2004	NUM
cusj-7788	170	12	)	)	PUNCT
cusj-7788	171	1	apobec3	apobec3	ADP
cusj-7788	171	2	g	g	ADP
cusj-7788	171	3	genetic	genetic	ADJ
cusj-7788	171	4	variants	variant	NOUN
cusj-7788	171	5	and	and	CCONJ
cusj-7788	171	6	their	their	PRON
cusj-7788	171	7	influence	influence	NOUN
cusj-7788	171	8	on	on	ADP
cusj-7788	171	9	the	the	DET
cusj-7788	171	10	progression	progression	NOUN
cusj-7788	171	11	to	to	ADP
cusj-7788	171	12	aids	aids	PROPN
cusj-7788	171	13	.	.	PUNCT
cusj-7788	172	1	journal	journal	PROPN
cusj-7788	172	2	of	of	ADP
cusj-7788	172	3	virology	virology	NOUN
cusj-7788	172	4	78	78	NUM
cusj-7788	172	5	:	:	PUNCT
cusj-7788	172	6	11070–11076	11070–11076	NUM
cusj-7788	172	7	.	.	PUNCT
cusj-7788	173	1	[	[	X
cusj-7788	173	2	10	10	NUM
cusj-7788	173	3	]	]	PUNCT
cusj-7788	173	4	borzooee	borzooee	NOUN
cusj-7788	173	5	f	f	PROPN
cusj-7788	173	6	,	,	PUNCT
cusj-7788	173	7	joris	joris	PROPN
cusj-7788	173	8	kd	kd	PROPN
cusj-7788	173	9	,	,	PUNCT
cusj-7788	173	10	grant	grant	PROPN
cusj-7788	173	11	md	md	PROPN
cusj-7788	173	12	,	,	PUNCT
cusj-7788	173	13	larijani	larijani	NOUN
cusj-7788	173	14	m	m	PROPN
cusj-7788	173	15	(	(	PUNCT
cusj-7788	173	16	2019	2019	NUM
cusj-7788	173	17	)	)	PUNCT
cusj-7788	173	18	apobec3	apobec3	ADP
cusj-7788	173	19	g	g	ADP
cusj-7788	173	20	regulation	regulation	NOUN
cusj-7788	173	21	of	of	ADP
cusj-7788	173	22	the	the	DET
cusj-7788	173	23	evolutionary	evolutionary	ADJ
cusj-7788	173	24	race	race	NOUN
cusj-7788	173	25	between	between	ADP
cusj-7788	173	26	adaptive	adaptive	ADJ
cusj-7788	173	27	immunity	immunity	NOUN
cusj-7788	173	28	and	and	CCONJ
cusj-7788	173	29	viral	viral	ADJ
cusj-7788	173	30	immune	immune	ADJ
cusj-7788	173	31	escape	escape	NOUN
cusj-7788	173	32	is	be	AUX
cusj-7788	173	33	deeply	deeply	ADV
cusj-7788	173	34	imprinted	imprint	VERB
cusj-7788	173	35	in	in	ADP
cusj-7788	173	36	the	the	DET
cusj-7788	173	37	hiv	hiv	PROPN
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cusj-7788	173	39	.	.	PUNCT
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cusj-7788	174	2	in	in	ADP
cusj-7788	174	3	immunology	immunology	NOUN
cusj-7788	174	4	9	9	NUM
cusj-7788	174	5	.	.	PUNCT
cusj-7788	174	6	doi:10.3389	doi:10.3389	PROPN
cusj-7788	174	7	/	/	SYM
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cusj-7788	174	9	.	.	PUNCT
cusj-7788	175	1	[	[	X
cusj-7788	175	2	11	11	NUM
cusj-7788	175	3	]	]	PUNCT
cusj-7788	175	4	mulder	mulder	PROPN
cusj-7788	175	5	lcf	lcf	PROPN
cusj-7788	175	6	,	,	PUNCT
cusj-7788	175	7	harari	harari	PROPN
cusj-7788	175	8	a	a	X
cusj-7788	175	9	,	,	PUNCT
cusj-7788	175	10	simon	simon	PROPN
cusj-7788	175	11	v	v	PROPN
cusj-7788	175	12	(	(	PUNCT
cusj-7788	175	13	2008	2008	NUM
cusj-7788	175	14	)	)	PUNCT
cusj-7788	175	15	cytidine	cytidine	NOUN
cusj-7788	175	16	deamination	deamination	NOUN
cusj-7788	175	17	induced	induce	VERB
cusj-7788	175	18	hiv-1	hiv-1	X
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cusj-7788	175	20	resistance	resistance	NOUN
cusj-7788	175	21	.	.	PUNCT
cusj-7788	176	1	proceedings	proceeding	NOUN
cusj-7788	176	2	of	of	ADP
cusj-7788	176	3	the	the	DET
cusj-7788	176	4	national	national	PROPN
cusj-7788	176	5	academy	academy	PROPN
cusj-7788	176	6	of	of	ADP
cusj-7788	176	7	sciences	sciences	PROPN
cusj-7788	176	8	105(14):5501–5506	105(14):5501–5506	NOUN
cusj-7788	176	9	.	.	PUNCT
cusj-7788	177	1	[	[	X
cusj-7788	177	2	12	12	NUM
cusj-7788	177	3	]	]	X
cusj-7788	177	4	hernandez	hernandez	PROPN
cusj-7788	177	5	mm	mm	PROPN
cusj-7788	177	6	,	,	PUNCT
cusj-7788	177	7	et	et	PROPN
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cusj-7788	177	10	(	(	PUNCT
cusj-7788	177	11	2019	2019	NUM
cusj-7788	177	12	)	)	PUNCT
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cusj-7788	177	16	apobec3	apobec3	PROPN
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cusj-7788	178	5	)	)	PUNCT
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cusj-7788	180	2	13	13	NUM
cusj-7788	180	3	]	]	PUNCT
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cusj-7788	180	11	)	)	PUNCT
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cusj-7788	180	17	hiv	hiv	PROPN
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cusj-7788	180	25	f	f	PROPN
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cusj-7788	180	27	.	.	PUNCT
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cusj-7788	181	5	14(1	14(1	NUM
cusj-7788	181	6	)	)	PUNCT
cusj-7788	181	7	.	.	PUNCT
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cusj-7788	182	2	/	/	SYM
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cusj-7788	182	4	-	-	PUNCT
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cusj-7788	182	6	-	-	SYM
cusj-7788	182	7	8	8	NUM
cusj-7788	182	8	.	.	PUNCT
cusj-7788	183	1	[	[	X
cusj-7788	183	2	14	14	NUM
cusj-7788	183	3	]	]	X
cusj-7788	183	4	cadena	cadena	PROPN
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cusj-7788	183	6	,	,	PUNCT
cusj-7788	183	7	et	et	PROPN
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cusj-7788	184	1	(	(	PUNCT
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cusj-7788	184	3	)	)	PUNCT
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cusj-7788	184	7	hiv1	hiv1	PROPN
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cusj-7788	184	10	on	on	ADP
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cusj-7788	184	12	g	g	NOUN
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cusj-7788	184	14	-	-	ADJ
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cusj-7788	184	19	in	in	ADP
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cusj-7788	185	2	13(1	13(1	NUM
cusj-7788	185	3	)	)	PUNCT
cusj-7788	185	4	.	.	PUNCT
cusj-7788	186	1	doi:10.1186	doi:10.1186	PROPN
cusj-7788	186	2	/	/	SYM
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cusj-7788	186	4	-	-	PUNCT
cusj-7788	186	5	016	016	NUM
cusj-7788	186	6	-	-	PUNCT
cusj-7788	186	7	0280	0280	NUM
cusj-7788	186	8	-	-	PUNCT
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