id	sid	tid	token	lemma	pos
cbi-27	1	1	v2018i1	v2018i1	PROPN
cbi-27	1	2	volume	volume	NOUN
cbi-27	1	3	1	1	NUM
cbi-27	1	4	,	,	PUNCT
cbi-27	1	5	issue	issue	NOUN
cbi-27	1	6	1	1	NUM
cbi-27	1	7	a	a	DET
cbi-27	1	8	proposed	propose	VERB
cbi-27	1	9	framework	framework	NOUN
cbi-27	1	10	for	for	ADP
cbi-27	1	11	cellular	cellular	ADJ
cbi-27	1	12	evolution	evolution	NOUN
cbi-27	1	13	albert	albert	PROPN
cbi-27	1	14	d.	d.	PROPN
cbi-27	1	15	g.	g.	PROPN
cbi-27	1	16	de	de	PROPN
cbi-27	1	17	roos	roos	PROPN
cbi-27	1	18	doi	doi	PROPN
cbi-27	1	19	:	:	PUNCT
cbi-27	1	20	10.33014	10.33014	NUM
cbi-27	1	21	/	/	SYM
cbi-27	1	22	issn.2640	issn.2640	ADJ
cbi-27	1	23	-	-	PUNCT
cbi-27	1	24	5652.1.1.deroos.1	5652.1.1.deroos.1	NOUN
cbi-27	1	25	abstract	abstract	NOUN
cbi-27	1	26	this	this	DET
cbi-27	1	27	article	article	NOUN
cbi-27	1	28	shows	show	VERB
cbi-27	1	29	how	how	SCONJ
cbi-27	1	30	a	a	DET
cbi-27	1	31	good	good	ADJ
cbi-27	1	32	understanding	understanding	NOUN
cbi-27	1	33	of	of	ADP
cbi-27	1	34	the	the	DET
cbi-27	1	35	design	design	NOUN
cbi-27	1	36	principles	principle	NOUN
cbi-27	1	37	that	that	PRON
cbi-27	1	38	underlie	underlie	ADJ
cbi-27	1	39	life	life	NOUN
cbi-27	1	40	is	be	AUX
cbi-27	1	41	crucial	crucial	ADJ
cbi-27	1	42	in	in	ADP
cbi-27	1	43	understanding	understand	VERB
cbi-27	1	44	its	its	PRON
cbi-27	1	45	evolution	evolution	NOUN
cbi-27	1	46	.	.	PUNCT
cbi-27	2	1	it	it	PRON
cbi-27	2	2	gives	give	VERB
cbi-27	2	3	concrete	concrete	ADJ
cbi-27	2	4	examples	example	NOUN
cbi-27	2	5	on	on	ADP
cbi-27	2	6	how	how	SCONJ
cbi-27	2	7	designs	design	NOUN
cbi-27	2	8	can	can	AUX
cbi-27	2	9	be	be	AUX
cbi-27	2	10	applied	apply	VERB
cbi-27	2	11	to	to	ADP
cbi-27	2	12	evolution	evolution	NOUN
cbi-27	2	13	in	in	ADP
cbi-27	2	14	the	the	DET
cbi-27	2	15	same	same	ADJ
cbi-27	2	16	way	way	NOUN
cbi-27	2	17	an	an	DET
cbi-27	2	18	engineer	engineer	NOUN
cbi-27	2	19	uses	use	VERB
cbi-27	2	20	designs	design	NOUN
cbi-27	2	21	in	in	ADP
cbi-27	2	22	creating	create	VERB
cbi-27	2	23	building	building	NOUN
cbi-27	2	24	or	or	CCONJ
cbi-27	2	25	bridges	bridge	NOUN
cbi-27	2	26	,	,	PUNCT
cbi-27	2	27	or	or	CCONJ
cbi-27	2	28	a	a	DET
cbi-27	2	29	software	software	NOUN
cbi-27	2	30	engineer	engineer	NOUN
cbi-27	2	31	that	that	PRON
cbi-27	2	32	designs	design	VERB
cbi-27	2	33	programs	program	NOUN
cbi-27	2	34	that	that	PRON
cbi-27	2	35	can	can	AUX
cbi-27	2	36	evolve	evolve	VERB
cbi-27	2	37	.	.	PUNCT
cbi-27	3	1	if	if	SCONJ
cbi-27	3	2	we	we	PRON
cbi-27	3	3	apply	apply	VERB
cbi-27	3	4	the	the	DET
cbi-27	3	5	notion	notion	NOUN
cbi-27	3	6	of	of	ADP
cbi-27	3	7	a	a	DET
cbi-27	3	8	design	design	NOUN
cbi-27	3	9	for	for	ADP
cbi-27	3	10	evolution	evolution	NOUN
cbi-27	3	11	and	and	CCONJ
cbi-27	3	12	realize	realize	VERB
cbi-27	3	13	that	that	SCONJ
cbi-27	3	14	it	it	PRON
cbi-27	3	15	is	be	AUX
cbi-27	3	16	in	in	ADP
cbi-27	3	17	its	its	PRON
cbi-27	3	18	basis	basis	NOUN
cbi-27	3	19	an	an	DET
cbi-27	3	20	evolving	evolve	VERB
cbi-27	3	21	system	system	NOUN
cbi-27	3	22	of	of	ADP
cbi-27	3	23	molecular	molecular	ADJ
cbi-27	3	24	machines	machine	NOUN
cbi-27	3	25	,	,	PUNCT
cbi-27	3	26	we	we	PRON
cbi-27	3	27	can	can	AUX
cbi-27	3	28	start	start	VERB
cbi-27	3	29	to	to	PART
cbi-27	3	30	reverse	reverse	VERB
cbi-27	3	31	engineer	engineer	NOUN
cbi-27	3	32	evolution	evolution	NOUN
cbi-27	3	33	and	and	CCONJ
cbi-27	3	34	understand	understand	VERB
cbi-27	3	35	life	life	NOUN
cbi-27	3	36	.	.	PUNCT
cbi-27	4	1	this	this	DET
cbi-27	4	2	article	article	NOUN
cbi-27	4	3	shows	show	VERB
cbi-27	4	4	scenario	scenario	PROPN
cbi-27	4	5	’s	’s	PART
cbi-27	4	6	for	for	ADP
cbi-27	4	7	the	the	DET
cbi-27	4	8	origin	origin	NOUN
cbi-27	4	9	of	of	ADP
cbi-27	4	10	life	life	NOUN
cbi-27	4	11	and	and	CCONJ
cbi-27	4	12	cellular	cellular	ADJ
cbi-27	4	13	life	life	NOUN
cbi-27	4	14	and	and	CCONJ
cbi-27	4	15	how	how	SCONJ
cbi-27	4	16	eukaryotic	eukaryotic	ADJ
cbi-27	4	17	cells	cell	NOUN
cbi-27	4	18	evolved	evolve	VERB
cbi-27	4	19	to	to	ADP
cbi-27	4	20	multicellular	multicellular	ADJ
cbi-27	4	21	organisms	organism	NOUN
cbi-27	4	22	.	.	PUNCT
cbi-27	5	1	the	the	DET
cbi-27	5	2	driving	drive	VERB
cbi-27	5	3	force	force	NOUN
cbi-27	5	4	for	for	ADP
cbi-27	5	5	evolution	evolution	NOUN
cbi-27	5	6	would	would	AUX
cbi-27	5	7	be	be	AUX
cbi-27	5	8	the	the	DET
cbi-27	5	9	intrinsic	intrinsic	ADJ
cbi-27	5	10	capability	capability	NOUN
cbi-27	5	11	of	of	ADP
cbi-27	5	12	the	the	DET
cbi-27	5	13	molecular	molecular	ADJ
cbi-27	5	14	machines	machine	NOUN
cbi-27	5	15	to	to	PART
cbi-27	5	16	evolve	evolve	VERB
cbi-27	5	17	and	and	CCONJ
cbi-27	5	18	this	this	DET
cbi-27	5	19	basic	basic	ADJ
cbi-27	5	20	tendency	tendency	NOUN
cbi-27	5	21	to	to	PART
cbi-27	5	22	evolve	evolve	VERB
cbi-27	5	23	its	its	PRON
cbi-27	5	24	ultimate	ultimate	ADJ
cbi-27	5	25	goal	goal	NOUN
cbi-27	5	26	.	.	PUNCT
cbi-27	6	1	the	the	DET
cbi-27	6	2	scenarios	scenario	NOUN
cbi-27	6	3	that	that	PRON
cbi-27	6	4	can	can	AUX
cbi-27	6	5	be	be	AUX
cbi-27	6	6	deduced	deduce	VERB
cbi-27	6	7	following	follow	VERB
cbi-27	6	8	a	a	DET
cbi-27	6	9	design	design	NOUN
cbi-27	6	10	framework	framework	NOUN
cbi-27	6	11	are	be	AUX
cbi-27	6	12	drastically	drastically	ADV
cbi-27	6	13	different	different	ADJ
cbi-27	6	14	from	from	ADP
cbi-27	6	15	the	the	DET
cbi-27	6	16	theories	theory	NOUN
cbi-27	6	17	that	that	PRON
cbi-27	6	18	have	have	AUX
cbi-27	6	19	been	be	AUX
cbi-27	6	20	proposed	propose	VERB
cbi-27	6	21	so	so	ADV
cbi-27	6	22	far	far	ADV
cbi-27	6	23	.	.	PUNCT
cbi-27	7	1	based	base	VERB
cbi-27	7	2	on	on	ADP
cbi-27	7	3	the	the	DET
cbi-27	7	4	premise	premise	NOUN
cbi-27	7	5	that	that	SCONJ
cbi-27	7	6	that	that	DET
cbi-27	7	7	evolution	evolution	NOUN
cbi-27	7	8	can	can	AUX
cbi-27	7	9	be	be	AUX
cbi-27	7	10	modeled	model	VERB
cbi-27	7	11	on	on	ADP
cbi-27	7	12	a	a	DET
cbi-27	7	13	design	design	NOUN
cbi-27	7	14	framework	framework	NOUN
cbi-27	7	15	,	,	PUNCT
cbi-27	7	16	we	we	PRON
cbi-27	7	17	can	can	AUX
cbi-27	7	18	deduce	deduce	VERB
cbi-27	7	19	that	that	DET
cbi-27	7	20	life	life	NOUN
cbi-27	7	21	evolved	evolve	VERB
cbi-27	7	22	inside	inside	NOUN
cbi-27	7	23	-	-	PUNCT
cbi-27	7	24	out	out	NOUN
cbi-27	7	25	and	and	CCONJ
cbi-27	7	26	that	that	DET
cbi-27	7	27	ontology	ontology	NOUN
cbi-27	7	28	reflects	reflect	VERB
cbi-27	7	29	phylogeny	phylogeny	NOUN
cbi-27	7	30	on	on	ADP
cbi-27	7	31	a	a	DET
cbi-27	7	32	molecular	molecular	ADJ
cbi-27	7	33	basis	basis	NOUN
cbi-27	7	34	1	1	NUM
cbi-27	7	35	evolving	evolve	VERB
cbi-27	7	36	machines	machine	NOUN
cbi-27	7	37	1.1	1.1	NUM
cbi-27	7	38	evolution	evolution	NOUN
cbi-27	7	39	of	of	ADP
cbi-27	7	40	the	the	DET
cbi-27	7	41	eukaryotes	eukaryote	NOUN
cbi-27	7	42	in	in	ADP
cbi-27	7	43	order	order	NOUN
cbi-27	7	44	to	to	PART
cbi-27	7	45	understand	understand	VERB
cbi-27	7	46	life	life	NOUN
cbi-27	7	47	and	and	CCONJ
cbi-27	7	48	its	its	PRON
cbi-27	7	49	evolution	evolution	NOUN
cbi-27	7	50	,	,	PUNCT
cbi-27	7	51	we	we	PRON
cbi-27	7	52	first	first	ADV
cbi-27	7	53	have	have	VERB
cbi-27	7	54	to	to	PART
cbi-27	7	55	see	see	VERB
cbi-27	7	56	how	how	SCONJ
cbi-27	7	57	living	living	ADJ
cbi-27	7	58	organisms	organism	NOUN
cbi-27	7	59	function	function	VERB
cbi-27	7	60	.	.	PUNCT
cbi-27	8	1	the	the	DET
cbi-27	8	2	cell	cell	NOUN
cbi-27	8	3	is	be	AUX
cbi-27	8	4	the	the	DET
cbi-27	8	5	main	main	ADJ
cbi-27	8	6	building	building	NOUN
cbi-27	8	7	block	block	NOUN
cbi-27	8	8	of	of	ADP
cbi-27	8	9	all	all	DET
cbi-27	8	10	organisms	organism	NOUN
cbi-27	8	11	and	and	CCONJ
cbi-27	8	12	is	be	AUX
cbi-27	8	13	in	in	ADP
cbi-27	8	14	itself	itself	PRON
cbi-27	8	15	a	a	DET
cbi-27	8	16	small	small	ADJ
cbi-27	8	17	molecular	molecular	ADJ
cbi-27	8	18	machine	machine	NOUN
cbi-27	8	19	,	,	PUNCT
cbi-27	8	20	illustrated	illustrate	VERB
cbi-27	8	21	nicely	nicely	ADV
cbi-27	8	22	by	by	ADP
cbi-27	8	23	the	the	DET
cbi-27	8	24	cell	cell	NOUN
cbi-27	8	25	cycle	cycle	NOUN
cbi-27	8	26	.	.	PUNCT
cbi-27	9	1	in	in	ADP
cbi-27	9	2	higher	high	ADJ
cbi-27	9	3	multicellular	multicellular	ADJ
cbi-27	9	4	organisms	organism	NOUN
cbi-27	9	5	,	,	PUNCT
cbi-27	9	6	the	the	DET
cbi-27	9	7	cells	cell	NOUN
cbi-27	9	8	have	have	AUX
cbi-27	9	9	specialized	specialize	VERB
cbi-27	9	10	and	and	CCONJ
cbi-27	9	11	formed	form	VERB
cbi-27	9	12	into	into	ADP
cbi-27	9	13	organs	organ	NOUN
cbi-27	9	14	and	and	CCONJ
cbi-27	9	15	limbs	limb	NOUN
cbi-27	9	16	but	but	CCONJ
cbi-27	9	17	the	the	DET
cbi-27	9	18	cell	cell	NOUN
cbi-27	9	19	remains	remain	VERB
cbi-27	9	20	the	the	DET
cbi-27	9	21	main	main	ADJ
cbi-27	9	22	building	building	NOUN
cbi-27	9	23	block	block	NOUN
cbi-27	9	24	.	.	PUNCT
cbi-27	10	1	the	the	DET
cbi-27	10	2	mechanistic	mechanistic	ADJ
cbi-27	10	3	organization	organization	NOUN
cbi-27	10	4	of	of	ADP
cbi-27	10	5	multicellularity	multicellularity	NOUN
cbi-27	10	6	can	can	AUX
cbi-27	10	7	be	be	AUX
cbi-27	10	8	easily	easily	ADV
cbi-27	10	9	seen	see	VERB
cbi-27	10	10	when	when	SCONJ
cbi-27	10	11	we	we	PRON
cbi-27	10	12	look	look	VERB
cbi-27	10	13	at	at	ADP
cbi-27	10	14	development	development	NOUN
cbi-27	10	15	from	from	ADP
cbi-27	10	16	a	a	DET
cbi-27	10	17	fertilized	fertilize	VERB
cbi-27	10	18	egg	egg	NOUN
cbi-27	10	19	to	to	ADP
cbi-27	10	20	an	an	DET
cbi-27	10	21	organism	organism	NOUN
cbi-27	10	22	.	.	PUNCT
cbi-27	11	1	the	the	DET
cbi-27	11	2	evolution	evolution	NOUN
cbi-27	11	3	of	of	ADP
cbi-27	11	4	life	life	NOUN
cbi-27	11	5	starts	start	VERB
cbi-27	11	6	with	with	ADP
cbi-27	11	7	the	the	DET
cbi-27	11	8	evolution	evolution	NOUN
cbi-27	11	9	of	of	ADP
cbi-27	11	10	the	the	DET
cbi-27	11	11	cell	cell	NOUN
cbi-27	11	12	,	,	PUNCT
cbi-27	11	13	specifically	specifically	ADV
cbi-27	11	14	the	the	DET
cbi-27	11	15	eukaryotic	eukaryotic	ADJ
cbi-27	11	16	cells	cell	NOUN
cbi-27	11	17	that	that	PRON
cbi-27	11	18	contain	contain	VERB
cbi-27	11	19	a	a	DET
cbi-27	11	20	nucleus	nucleus	NOUN
cbi-27	11	21	and	and	CCONJ
cbi-27	11	22	forms	form	VERB
cbi-27	11	23	the	the	DET
cbi-27	11	24	basis	basis	NOUN
cbi-27	11	25	of	of	ADP
cbi-27	11	26	all	all	DET
cbi-27	11	27	higher	high	ADJ
cbi-27	11	28	life	life	NOUN
cbi-27	11	29	.	.	PUNCT
cbi-27	12	1	this	this	DET
cbi-27	12	2	paper	paper	NOUN
cbi-27	12	3	concentrates	concentrate	VERB
cbi-27	12	4	on	on	ADP
cbi-27	12	5	the	the	DET
cbi-27	12	6	evolution	evolution	NOUN
cbi-27	12	7	of	of	ADP
cbi-27	12	8	the	the	DET
cbi-27	12	9	eukaryotic	eukaryotic	ADJ
cbi-27	12	10	cell	cell	NOUN
cbi-27	12	11	,	,	PUNCT
cbi-27	12	12	which	which	PRON
cbi-27	12	13	includes	include	VERB
cbi-27	12	14	not	not	PART
cbi-27	12	15	only	only	ADV
cbi-27	12	16	all	all	PRON
cbi-27	12	17	plants	plant	NOUN
cbi-27	12	18	and	and	CCONJ
cbi-27	12	19	animals	animal	NOUN
cbi-27	12	20	,	,	PUNCT
cbi-27	12	21	but	but	CCONJ
cbi-27	12	22	also	also	ADV
cbi-27	12	23	protists	protist	NOUN
cbi-27	12	24	such	such	ADJ
cbi-27	12	25	as	as	ADP
cbi-27	12	26	algae	algae	NOUN
cbi-27	12	27	and	and	CCONJ
cbi-27	12	28	yeast	yeast	NOUN
cbi-27	12	29	.	.	PUNCT
cbi-27	13	1	1.2	1.2	NUM
cbi-27	13	2	cells	cell	NOUN
cbi-27	13	3	are	be	AUX
cbi-27	13	4	molecular	molecular	ADJ
cbi-27	13	5	machines	machine	NOUN
cbi-27	13	6	the	the	DET
cbi-27	13	7	basic	basic	ADJ
cbi-27	13	8	premise	premise	NOUN
cbi-27	13	9	underlying	underlie	VERB
cbi-27	13	10	the	the	DET
cbi-27	13	11	study	study	NOUN
cbi-27	13	12	of	of	ADP
cbi-27	13	13	design	design	NOUN
cbi-27	13	14	in	in	ADP
cbi-27	13	15	evolution	evolution	NOUN
cbi-27	13	16	is	be	AUX
cbi-27	13	17	that	that	SCONJ
cbi-27	13	18	the	the	DET
cbi-27	13	19	eukaryotic	eukaryotic	ADJ
cbi-27	13	20	cell	cell	NOUN
cbi-27	13	21	is	be	AUX
cbi-27	13	22	basically	basically	ADV
cbi-27	13	23	a	a	DET
cbi-27	13	24	small	small	ADJ
cbi-27	13	25	molecular	molecular	ADJ
cbi-27	13	26	machine	machine	NOUN
cbi-27	13	27	where	where	SCONJ
cbi-27	13	28	the	the	DET
cbi-27	13	29	components	component	NOUN
cbi-27	13	30	are	be	AUX
cbi-27	13	31	formed	form	VERB
cbi-27	13	32	by	by	ADP
cbi-27	13	33	molecules	molecule	NOUN
cbi-27	13	34	.	.	PUNCT
cbi-27	14	1	cell	cell	NOUN
cbi-27	14	2	membranes	membrane	NOUN
cbi-27	14	3	are	be	AUX
cbi-27	14	4	formed	form	VERB
cbi-27	14	5	by	by	ADP
cbi-27	14	6	lipid	lipid	ADJ
cbi-27	14	7	bilayers	bilayer	NOUN
cbi-27	14	8	,	,	PUNCT
cbi-27	14	9	the	the	DET
cbi-27	14	10	cytoskeleton	cytoskeleton	NOUN
cbi-27	14	11	is	be	AUX
cbi-27	14	12	made	make	VERB
cbi-27	14	13	up	up	ADP
cbi-27	14	14	of	of	ADP
cbi-27	14	15	protein	protein	NOUN
cbi-27	14	16	fibers	fiber	NOUN
cbi-27	14	17	,	,	PUNCT
cbi-27	14	18	our	our	PRON
cbi-27	14	19	genetic	genetic	ADJ
cbi-27	14	20	material	material	NOUN
cbi-27	14	21	is	be	AUX
cbi-27	14	22	made	make	VERB
cbi-27	14	23	up	up	ADP
cbi-27	14	24	of	of	ADP
cbi-27	14	25	a	a	DET
cbi-27	14	26	double	double	ADJ
cbi-27	14	27	stranded	strand	VERB
cbi-27	14	28	helix	helix	NOUN
cbi-27	14	29	.	.	PUNCT
cbi-27	15	1	there	there	PRON
cbi-27	15	2	is	be	VERB
cbi-27	15	3	machinery	machinery	NOUN
cbi-27	15	4	that	that	PRON
cbi-27	15	5	can	can	AUX
cbi-27	15	6	assemble	assemble	VERB
cbi-27	15	7	these	these	DET
cbi-27	15	8	materials	material	NOUN
cbi-27	15	9	illustrated	illustrate	VERB
cbi-27	15	10	by	by	ADP
cbi-27	15	11	cell	cell	NOUN
cbi-27	15	12	division	division	NOUN
cbi-27	15	13	showing	show	VERB
cbi-27	15	14	a	a	DET
cbi-27	15	15	carefully	carefully	ADV
cbi-27	15	16	orchestrated	orchestrate	VERB
cbi-27	15	17	sequence	sequence	NOUN
cbi-27	15	18	of	of	ADP
cbi-27	15	19	mechanical	mechanical	ADJ
cbi-27	15	20	events	event	NOUN
cbi-27	15	21	.	.	PUNCT
cbi-27	16	1	in	in	ADP
cbi-27	16	2	this	this	DET
cbi-27	16	3	process	process	NOUN
cbi-27	16	4	of	of	ADP
cbi-27	16	5	cell	cell	NOUN
cbi-27	16	6	division	division	NOUN
cbi-27	16	7	,	,	PUNCT
cbi-27	16	8	dna	dna	PROPN
cbi-27	16	9	has	have	VERB
cbi-27	16	10	to	to	PART
cbi-27	16	11	be	be	AUX
cbi-27	16	12	replicated	replicate	VERB
cbi-27	16	13	,	,	PUNCT
cbi-27	16	14	the	the	DET
cbi-27	16	15	nuclear	nuclear	ADJ
cbi-27	16	16	membrane	membrane	NOUN
cbi-27	16	17	dissolved	dissolve	VERB
cbi-27	16	18	,	,	PUNCT
cbi-27	16	19	chromosomes	chromosome	NOUN
cbi-27	16	20	condensed	condense	VERB
cbi-27	16	21	and	and	CCONJ
cbi-27	16	22	aligned	align	VERB
cbi-27	16	23	,	,	PUNCT
cbi-27	16	24	the	the	DET
cbi-27	16	25	replicated	replicate	VERB
cbi-27	16	26	chromosomes	chromosome	NOUN
cbi-27	16	27	need	need	VERB
cbi-27	16	28	to	to	PART
cbi-27	16	29	be	be	AUX
cbi-27	16	30	pulled	pull	VERB
cbi-27	16	31	apart	apart	ADV
cbi-27	16	32	,	,	PUNCT
cbi-27	16	33	the	the	DET
cbi-27	16	34	nuclear	nuclear	ADJ
cbi-27	16	35	membranes	membrane	NOUN
cbi-27	16	36	reformed	reform	VERB
cbi-27	16	37	and	and	CCONJ
cbi-27	16	38	the	the	DET
cbi-27	16	39	physical	physical	ADJ
cbi-27	16	40	split	split	NOUN
cbi-27	16	41	of	of	ADP
cbi-27	16	42	the	the	DET
cbi-27	16	43	two	two	NUM
cbi-27	16	44	daughter	daughter	NOUN
cbi-27	16	45	nuclei	nucleus	NOUN
cbi-27	16	46	.	.	PUNCT
cbi-27	17	1	it	it	PRON
cbi-27	17	2	is	be	AUX
cbi-27	17	3	not	not	PART
cbi-27	17	4	hard	hard	ADJ
cbi-27	17	5	to	to	PART
cbi-27	17	6	see	see	VERB
cbi-27	17	7	this	this	PRON
cbi-27	17	8	as	as	ADP
cbi-27	17	9	a	a	DET
cbi-27	17	10	purely	purely	ADV
cbi-27	17	11	mechanistic	mechanistic	ADJ
cbi-27	17	12	process	process	NOUN
cbi-27	17	13	with	with	ADP
cbi-27	17	14	many	many	ADJ
cbi-27	17	15	checkpoints	checkpoint	NOUN
cbi-27	17	16	,	,	PUNCT
cbi-27	17	17	regulators	regulator	NOUN
cbi-27	17	18	,	,	PUNCT
cbi-27	17	19	machinery	machinery	NOUN
cbi-27	17	20	,	,	PUNCT
cbi-27	17	21	feed	feed	NOUN
cbi-27	17	22	-	-	PUNCT
cbi-27	17	23	back	back	NOUN
cbi-27	17	24	and	and	CCONJ
cbi-27	17	25	feed	feed	NOUN
cbi-27	17	26	-	-	PUNCT
cbi-27	17	27	forward	forward	NOUN
cbi-27	17	28	loops	loop	NOUN
cbi-27	17	29	and	and	CCONJ
cbi-27	17	30	self	self	NOUN
cbi-27	17	31	-	-	PUNCT
cbi-27	17	32	assembly	assembly	NOUN
cbi-27	17	33	of	of	ADP
cbi-27	17	34	machinery	machinery	NOUN
cbi-27	17	35	.	.	PUNCT
cbi-27	18	1	the	the	DET
cbi-27	18	2	question	question	NOUN
cbi-27	18	3	for	for	ADP
cbi-27	18	4	evolution	evolution	NOUN
cbi-27	18	5	is	be	AUX
cbi-27	18	6	how	how	SCONJ
cbi-27	18	7	this	this	DET
cbi-27	18	8	system	system	NOUN
cbi-27	18	9	evolved	evolve	VERB
cbi-27	18	10	and	and	CCONJ
cbi-27	18	11	how	how	SCONJ
cbi-27	18	12	the	the	DET
cbi-27	18	13	molecular	molecular	ADJ
cbi-27	18	14	components	component	NOUN
cbi-27	18	15	were	be	AUX
cbi-27	18	16	assembled	assemble	VERB
cbi-27	18	17	over	over	ADP
cbi-27	18	18	time	time	NOUN
cbi-27	18	19	.	.	PUNCT
cbi-27	19	1	1.3	1.3	NUM
cbi-27	19	2	development	development	NOUN
cbi-27	19	3	represents	represent	VERB
cbi-27	19	4	a	a	DET
cbi-27	19	5	mechanistic	mechanistic	ADJ
cbi-27	19	6	cycle	cycle	NOUN
cbi-27	19	7	just	just	ADV
cbi-27	19	8	as	as	SCONJ
cbi-27	19	9	the	the	DET
cbi-27	19	10	cycle	cycle	NOUN
cbi-27	19	11	of	of	ADP
cbi-27	19	12	individual	individual	ADJ
cbi-27	19	13	cells	cell	NOUN
cbi-27	19	14	,	,	PUNCT
cbi-27	19	15	the	the	DET
cbi-27	19	16	development	development	NOUN
cbi-27	19	17	of	of	ADP
cbi-27	19	18	an	an	DET
cbi-27	19	19	organism	organism	NOUN
cbi-27	19	20	from	from	ADP
cbi-27	19	21	fertilized	fertilize	VERB
cbi-27	19	22	egg	egg	NOUN
cbi-27	19	23	to	to	ADP
cbi-27	19	24	the	the	DET
cbi-27	19	25	adult	adult	NOUN
cbi-27	19	26	organism	organism	NOUN
cbi-27	19	27	is	be	AUX
cbi-27	19	28	also	also	ADV
cbi-27	19	29	a	a	DET
cbi-27	19	30	purely	purely	ADV
cbi-27	19	31	mechanical	mechanical	ADJ
cbi-27	19	32	process	process	NOUN
cbi-27	19	33	.	.	PUNCT
cbi-27	20	1	based	base	VERB
cbi-27	20	2	on	on	ADP
cbi-27	20	3	the	the	DET
cbi-27	20	4	genetic	genetic	ADJ
cbi-27	20	5	blueprint	blueprint	NOUN
cbi-27	20	6	containing	contain	VERB
cbi-27	20	7	the	the	DET
cbi-27	20	8	information	information	NOUN
cbi-27	20	9	for	for	ADP
cbi-27	20	10	the	the	DET
cbi-27	20	11	protein	protein	NOUN
cbi-27	20	12	components	component	NOUN
cbi-27	20	13	and	and	CCONJ
cbi-27	20	14	the	the	DET
cbi-27	20	15	assembly	assembly	NOUN
cbi-27	20	16	of	of	ADP
cbi-27	20	17	the	the	DET
cbi-27	20	18	organism	organism	NOUN
cbi-27	20	19	,	,	PUNCT
cbi-27	20	20	development	development	NOUN
cbi-27	20	21	consists	consist	VERB
cbi-27	20	22	of	of	ADP
cbi-27	20	23	selfassembly	selfassembly	ADV
cbi-27	20	24	,	,	PUNCT
cbi-27	20	25	feedback	feedback	NOUN
cbi-27	20	26	and	and	CCONJ
cbi-27	20	27	feedforward	feedforward	NOUN
cbi-27	20	28	loops	loop	NOUN
cbi-27	20	29	and	and	CCONJ
cbi-27	20	30	self	self	NOUN
cbi-27	20	31	-	-	PUNCT
cbi-27	20	32	learning	learn	VERB
cbi-27	20	33	systems	system	NOUN
cbi-27	20	34	.	.	PUNCT
cbi-27	21	1	the	the	DET
cbi-27	21	2	sequence	sequence	NOUN
cbi-27	21	3	is	be	AUX
cbi-27	21	4	put	put	VERB
cbi-27	21	5	in	in	ADP
cbi-27	21	6	motion	motion	NOUN
cbi-27	21	7	be	be	AUX
cbi-27	21	8	the	the	DET
cbi-27	21	9	fertilization	fertilization	NOUN
cbi-27	21	10	of	of	ADP
cbi-27	21	11	the	the	DET
cbi-27	21	12	egg	egg	NOUN
cbi-27	21	13	until	until	ADP
cbi-27	21	14	the	the	DET
cbi-27	21	15	adult	adult	NOUN
cbi-27	21	16	organism	organism	NOUN
cbi-27	21	17	where	where	SCONJ
cbi-27	21	18	,	,	PUNCT
cbi-27	21	19	several	several	ADJ
cbi-27	21	20	genes	gene	NOUN
cbi-27	21	21	have	have	VERB
cbi-27	21	22	to	to	PART
cbi-27	21	23	be	be	AUX
cbi-27	21	24	activated	activate	VERB
cbi-27	21	25	at	at	ADP
cbi-27	21	26	specific	specific	ADJ
cbi-27	21	27	point	point	NOUN
cbi-27	21	28	in	in	ADP
cbi-27	21	29	time	time	NOUN
cbi-27	21	30	of	of	ADP
cbi-27	21	31	development	development	NOUN
cbi-27	21	32	.	.	PUNCT
cbi-27	22	1	in	in	ADP
cbi-27	22	2	humans	human	NOUN
cbi-27	22	3	,	,	PUNCT
cbi-27	22	4	development	development	NOUN
cbi-27	22	5	involves	involve	VERB
cbi-27	22	6	the	the	DET
cbi-27	22	7	coordinated	coordinated	ADJ
cbi-27	22	8	and	and	CCONJ
cbi-27	22	9	timely	timely	ADJ
cbi-27	22	10	activation	activation	NOUN
cbi-27	22	11	of	of	ADP
cbi-27	22	12	100,000	100,000	NUM
cbi-27	22	13	genes	gene	NOUN
cbi-27	22	14	over	over	ADP
cbi-27	22	15	a	a	DET
cbi-27	22	16	period	period	NOUN
cbi-27	22	17	of	of	ADP
cbi-27	22	18	more	more	ADJ
cbi-27	22	19	than	than	ADP
cbi-27	22	20	50	50	NUM
cbi-27	22	21	years	year	NOUN
cbi-27	22	22	.	.	PUNCT
cbi-27	23	1	this	this	DET
cbi-27	23	2	process	process	NOUN
cbi-27	23	3	is	be	AUX
cbi-27	23	4	tightly	tightly	ADV
cbi-27	23	5	regulated	regulate	VERB
cbi-27	23	6	with	with	ADP
cbi-27	23	7	checkpoints	checkpoint	NOUN
cbi-27	23	8	and	and	CCONJ
cbi-27	23	9	many	many	ADJ
cbi-27	23	10	other	other	ADJ
cbi-27	23	11	regulatory	regulatory	ADJ
cbi-27	23	12	processes	process	NOUN
cbi-27	23	13	that	that	PRON
cbi-27	23	14	check	check	VERB
cbi-27	23	15	certain	certain	ADJ
cbi-27	23	16	condition	condition	NOUN
cbi-27	23	17	before	before	ADP
cbi-27	23	18	progressing	progress	VERB
cbi-27	23	19	cell	cell	NOUN
cbi-27	23	20	division	division	NOUN
cbi-27	23	21	and	and	CCONJ
cbi-27	23	22	organ	organ	NOUN
cbi-27	23	23	formation	formation	NOUN
cbi-27	23	24	.	.	PUNCT
cbi-27	24	1	the	the	DET
cbi-27	24	2	evolution	evolution	NOUN
cbi-27	24	3	of	of	ADP
cbi-27	24	4	such	such	DET
cbi-27	24	5	a	a	DET
cbi-27	24	6	multicellular	multicellular	ADJ
cbi-27	24	7	system	system	NOUN
cbi-27	24	8	adds	add	VERB
cbi-27	24	9	another	another	DET
cbi-27	24	10	dimension	dimension	NOUN
cbi-27	24	11	to	to	ADP
cbi-27	24	12	evolution	evolution	NOUN
cbi-27	24	13	,	,	PUNCT
cbi-27	24	14	because	because	SCONJ
cbi-27	24	15	we	we	PRON
cbi-27	24	16	look	look	VERB
cbi-27	24	17	at	at	ADP
cbi-27	24	18	the	the	DET
cbi-27	24	19	assembly	assembly	NOUN
cbi-27	24	20	of	of	ADP
cbi-27	24	21	the	the	DET
cbi-27	24	22	organism	organism	NOUN
cbi-27	24	23	over	over	ADP
cbi-27	24	24	time	time	NOUN
cbi-27	24	25	.	.	PUNCT
cbi-27	25	1	6	6	NUM
cbi-27	25	2	a	a	DET
cbi-27	25	3	proposed	propose	VERB
cbi-27	25	4	framework	framework	NOUN
cbi-27	25	5	for	for	ADP
cbi-27	25	6	cellular	cellular	ADJ
cbi-27	25	7	evolution	evolution	NOUN
cbi-27	25	8	1.4	1.4	NUM
cbi-27	25	9	the	the	DET
cbi-27	25	10	life	life	NOUN
cbi-27	25	11	cycle	cycle	NOUN
cbi-27	25	12	as	as	ADP
cbi-27	25	13	vehicle	vehicle	NOUN
cbi-27	25	14	for	for	ADP
cbi-27	25	15	evolution	evolution	NOUN
cbi-27	25	16	the	the	DET
cbi-27	25	17	life	life	NOUN
cbi-27	25	18	cycle	cycle	NOUN
cbi-27	25	19	of	of	ADP
cbi-27	25	20	an	an	DET
cbi-27	25	21	organism	organism	NOUN
cbi-27	25	22	is	be	AUX
cbi-27	25	23	defined	define	VERB
cbi-27	25	24	from	from	ADP
cbi-27	25	25	the	the	DET
cbi-27	25	26	single	single	ADJ
cbi-27	25	27	cell	cell	NOUN
cbi-27	25	28	or	or	CCONJ
cbi-27	25	29	fertilized	fertilize	VERB
cbi-27	25	30	egg	egg	NOUN
cbi-27	25	31	,	,	PUNCT
cbi-27	25	32	all	all	DET
cbi-27	25	33	the	the	DET
cbi-27	25	34	way	way	NOUN
cbi-27	25	35	through	through	ADP
cbi-27	25	36	development	development	NOUN
cbi-27	25	37	and	and	CCONJ
cbi-27	25	38	ultimately	ultimately	ADV
cbi-27	25	39	to	to	ADP
cbi-27	25	40	the	the	DET
cbi-27	25	41	rise	rise	NOUN
cbi-27	25	42	of	of	ADP
cbi-27	25	43	another	another	DET
cbi-27	25	44	new	new	ADJ
cbi-27	25	45	organism	organism	NOUN
cbi-27	25	46	by	by	ADP
cbi-27	25	47	fertilization	fertilization	NOUN
cbi-27	25	48	.	.	PUNCT
cbi-27	26	1	every	every	DET
cbi-27	26	2	life	life	NOUN
cbi-27	26	3	cycle	cycle	NOUN
cbi-27	26	4	has	have	VERB
cbi-27	26	5	to	to	PART
cbi-27	26	6	end	end	VERB
cbi-27	26	7	with	with	ADP
cbi-27	26	8	the	the	DET
cbi-27	26	9	birth	birth	NOUN
cbi-27	26	10	of	of	ADP
cbi-27	26	11	a	a	DET
cbi-27	26	12	new	new	ADJ
cbi-27	26	13	organism	organism	NOUN
cbi-27	26	14	and	and	CCONJ
cbi-27	26	15	the	the	DET
cbi-27	26	16	organism	organism	NOUN
cbi-27	26	17	should	should	AUX
cbi-27	26	18	always	always	ADV
cbi-27	26	19	reach	reach	VERB
cbi-27	26	20	the	the	DET
cbi-27	26	21	reproduction	reproduction	NOUN
cbi-27	26	22	phase	phase	NOUN
cbi-27	26	23	in	in	ADP
cbi-27	26	24	order	order	NOUN
cbi-27	26	25	to	to	PART
cbi-27	26	26	complete	complete	VERB
cbi-27	26	27	the	the	DET
cbi-27	26	28	cycle	cycle	NOUN
cbi-27	26	29	.	.	PUNCT
cbi-27	27	1	each	each	DET
cbi-27	27	2	step	step	NOUN
cbi-27	27	3	or	or	CCONJ
cbi-27	27	4	life	life	NOUN
cbi-27	27	5	cycle	cycle	NOUN
cbi-27	27	6	has	have	VERB
cbi-27	27	7	the	the	DET
cbi-27	27	8	potential	potential	NOUN
cbi-27	27	9	to	to	PART
cbi-27	27	10	add	add	VERB
cbi-27	27	11	extra	extra	ADJ
cbi-27	27	12	functionality	functionality	NOUN
cbi-27	27	13	and	and	CCONJ
cbi-27	27	14	thus	thus	ADV
cbi-27	27	15	evolve	evolve	VERB
cbi-27	27	16	,	,	PUNCT
cbi-27	27	17	but	but	CCONJ
cbi-27	27	18	throughout	throughout	ADP
cbi-27	27	19	evolution	evolution	NOUN
cbi-27	27	20	the	the	DET
cbi-27	27	21	development	development	NOUN
cbi-27	27	22	of	of	ADP
cbi-27	27	23	fertilized	fertilized	ADJ
cbi-27	27	24	egg	egg	NOUN
cbi-27	27	25	to	to	PART
cbi-27	27	26	mature	mature	VERB
cbi-27	27	27	organism	organism	NOUN
cbi-27	27	28	has	have	VERB
cbi-27	27	29	to	to	PART
cbi-27	27	30	be	be	AUX
cbi-27	27	31	fully	fully	ADV
cbi-27	27	32	functional	functional	ADJ
cbi-27	27	33	.	.	PUNCT
cbi-27	28	1	any	any	DET
cbi-27	28	2	functionality	functionality	NOUN
cbi-27	28	3	that	that	PRON
cbi-27	28	4	would	would	AUX
cbi-27	28	5	cause	cause	VERB
cbi-27	28	6	a	a	DET
cbi-27	28	7	cell	cell	NOUN
cbi-27	28	8	or	or	CCONJ
cbi-27	28	9	an	an	DET
cbi-27	28	10	organism	organism	NOUN
cbi-27	28	11	to	to	PART
cbi-27	28	12	cease	cease	VERB
cbi-27	28	13	functioning	function	VERB
cbi-27	28	14	and	and	CCONJ
cbi-27	28	15	to	to	PART
cbi-27	28	16	interrupt	interrupt	VERB
cbi-27	28	17	the	the	DET
cbi-27	28	18	reproductive	reproductive	ADJ
cbi-27	28	19	cycle	cycle	NOUN
cbi-27	28	20	would	would	AUX
cbi-27	28	21	stop	stop	VERB
cbi-27	28	22	to	to	PART
cbi-27	28	23	exist	exist	VERB
cbi-27	28	24	.	.	PUNCT
cbi-27	29	1	this	this	DET
cbi-27	29	2	essential	essential	ADJ
cbi-27	29	3	functional	functional	ADJ
cbi-27	29	4	continuity	continuity	NOUN
cbi-27	29	5	is	be	AUX
cbi-27	29	6	an	an	DET
cbi-27	29	7	important	important	ADJ
cbi-27	29	8	(	(	PUNCT
cbi-27	29	9	design	design	NOUN
cbi-27	29	10	)	)	PUNCT
cbi-27	29	11	constraint	constraint	NOUN
cbi-27	29	12	for	for	ADP
cbi-27	29	13	evolution	evolution	NOUN
cbi-27	29	14	implying	imply	VERB
cbi-27	29	15	that	that	SCONJ
cbi-27	29	16	all	all	DET
cbi-27	29	17	the	the	DET
cbi-27	29	18	steps	step	NOUN
cbi-27	29	19	in	in	ADP
cbi-27	29	20	evolution	evolution	NOUN
cbi-27	29	21	must	must	AUX
cbi-27	29	22	each	each	PRON
cbi-27	29	23	give	give	VERB
cbi-27	29	24	rise	rise	NOUN
cbi-27	29	25	to	to	ADP
cbi-27	29	26	a	a	DET
cbi-27	29	27	fully	fully	ADV
cbi-27	29	28	functional	functional	ADJ
cbi-27	29	29	organism	organism	NOUN
cbi-27	29	30	or	or	CCONJ
cbi-27	29	31	cell	cell	NOUN
cbi-27	29	32	system	system	NOUN
cbi-27	29	33	.	.	PUNCT
cbi-27	30	1	drastic	drastic	ADJ
cbi-27	30	2	redesigns	redesign	NOUN
cbi-27	30	3	are	be	AUX
cbi-27	30	4	impossible	impossible	ADJ
cbi-27	30	5	in	in	ADP
cbi-27	30	6	evolution	evolution	NOUN
cbi-27	30	7	as	as	SCONJ
cbi-27	30	8	they	they	PRON
cbi-27	30	9	would	would	AUX
cbi-27	30	10	certainly	certainly	ADV
cbi-27	30	11	break	break	VERB
cbi-27	30	12	the	the	DET
cbi-27	30	13	functional	functional	ADJ
cbi-27	30	14	continuity	continuity	NOUN
cbi-27	30	15	principle	principle	NOUN
cbi-27	30	16	.	.	PUNCT
cbi-27	31	1	1.5	1.5	NUM
cbi-27	31	2	incremental	incremental	ADJ
cbi-27	31	3	development	development	NOUN
cbi-27	31	4	in	in	ADP
cbi-27	31	5	line	line	NOUN
cbi-27	31	6	with	with	ADP
cbi-27	31	7	the	the	DET
cbi-27	31	8	principle	principle	NOUN
cbi-27	31	9	of	of	ADP
cbi-27	31	10	functional	functional	ADJ
cbi-27	31	11	continuity	continuity	NOUN
cbi-27	31	12	,	,	PUNCT
cbi-27	31	13	evolution	evolution	NOUN
cbi-27	31	14	can	can	AUX
cbi-27	31	15	be	be	AUX
cbi-27	31	16	seen	see	VERB
cbi-27	31	17	as	as	ADP
cbi-27	31	18	the	the	DET
cbi-27	31	19	incremental	incremental	ADJ
cbi-27	31	20	expansion	expansion	NOUN
cbi-27	31	21	of	of	ADP
cbi-27	31	22	an	an	DET
cbi-27	31	23	existing	exist	VERB
cbi-27	31	24	system	system	NOUN
cbi-27	31	25	.	.	PUNCT
cbi-27	32	1	the	the	DET
cbi-27	32	2	components	component	NOUN
cbi-27	32	3	of	of	ADP
cbi-27	32	4	the	the	DET
cbi-27	32	5	system	system	NOUN
cbi-27	32	6	are	be	AUX
cbi-27	32	7	re	re	VERB
cbi-27	32	8	-	-	VERB
cbi-27	32	9	assembled	assemble	VERB
cbi-27	32	10	during	during	ADP
cbi-27	32	11	development	development	NOUN
cbi-27	32	12	and	and	CCONJ
cbi-27	32	13	with	with	ADP
cbi-27	32	14	every	every	DET
cbi-27	32	15	life	life	NOUN
cbi-27	32	16	cycle	cycle	NOUN
cbi-27	32	17	,	,	PUNCT
cbi-27	32	18	there	there	PRON
cbi-27	32	19	is	be	VERB
cbi-27	32	20	the	the	DET
cbi-27	32	21	potential	potential	NOUN
cbi-27	32	22	for	for	ADP
cbi-27	32	23	new	new	ADJ
cbi-27	32	24	functionality	functionality	NOUN
cbi-27	32	25	.	.	PUNCT
cbi-27	33	1	mutations	mutation	NOUN
cbi-27	33	2	in	in	ADP
cbi-27	33	3	the	the	DET
cbi-27	33	4	genetic	genetic	ADJ
cbi-27	33	5	material	material	NOUN
cbi-27	33	6	can	can	AUX
cbi-27	33	7	give	give	VERB
cbi-27	33	8	rise	rise	NOUN
cbi-27	33	9	to	to	ADP
cbi-27	33	10	new	new	ADJ
cbi-27	33	11	sorts	sort	NOUN
cbi-27	33	12	of	of	ADP
cbi-27	33	13	protein	protein	NOUN
cbi-27	33	14	that	that	PRON
cbi-27	33	15	can	can	AUX
cbi-27	33	16	give	give	VERB
cbi-27	33	17	rise	rise	NOUN
cbi-27	33	18	to	to	ADP
cbi-27	33	19	new	new	ADJ
cbi-27	33	20	components	component	NOUN
cbi-27	33	21	of	of	ADP
cbi-27	33	22	the	the	DET
cbi-27	33	23	system	system	NOUN
cbi-27	33	24	.	.	PUNCT
cbi-27	34	1	all	all	DET
cbi-27	34	2	the	the	DET
cbi-27	34	3	changes	change	NOUN
cbi-27	34	4	that	that	PRON
cbi-27	34	5	have	have	AUX
cbi-27	34	6	occurred	occur	VERB
cbi-27	34	7	in	in	ADP
cbi-27	34	8	evolution	evolution	NOUN
cbi-27	34	9	and	and	CCONJ
cbi-27	34	10	that	that	PRON
cbi-27	34	11	give	give	VERB
cbi-27	34	12	rise	rise	NOUN
cbi-27	34	13	to	to	ADP
cbi-27	34	14	the	the	DET
cbi-27	34	15	specific	specific	ADJ
cbi-27	34	16	developmental	developmental	ADJ
cbi-27	34	17	pattern	pattern	NOUN
cbi-27	34	18	that	that	PRON
cbi-27	34	19	is	be	AUX
cbi-27	34	20	encrypted	encrypt	VERB
cbi-27	34	21	in	in	ADP
cbi-27	34	22	the	the	DET
cbi-27	34	23	genome	genome	NOUN
cbi-27	34	24	of	of	ADP
cbi-27	34	25	the	the	DET
cbi-27	34	26	cell	cell	NOUN
cbi-27	34	27	,	,	PUNCT
cbi-27	34	28	for	for	ADP
cbi-27	34	29	eukaryotic	eukaryotic	ADJ
cbi-27	34	30	cells	cell	NOUN
cbi-27	34	31	mainly	mainly	ADV
cbi-27	34	32	in	in	ADP
cbi-27	34	33	the	the	DET
cbi-27	34	34	chromosomes	chromosome	NOUN
cbi-27	34	35	in	in	ADP
cbi-27	34	36	the	the	DET
cbi-27	34	37	nucleus	nucleus	NOUN
cbi-27	34	38	.	.	PUNCT
cbi-27	35	1	in	in	ADP
cbi-27	35	2	this	this	DET
cbi-27	35	3	sense	sense	NOUN
cbi-27	35	4	,	,	PUNCT
cbi-27	35	5	evolution	evolution	NOUN
cbi-27	35	6	can	can	AUX
cbi-27	35	7	be	be	AUX
cbi-27	35	8	regarded	regard	VERB
cbi-27	35	9	as	as	ADP
cbi-27	35	10	a	a	DET
cbi-27	35	11	molecular	molecular	ADJ
cbi-27	35	12	machine	machine	NOUN
cbi-27	35	13	(	(	PUNCT
cbi-27	35	14	an	an	DET
cbi-27	35	15	organism	organism	NOUN
cbi-27	35	16	)	)	PUNCT
cbi-27	35	17	that	that	PRON
cbi-27	35	18	can	can	AUX
cbi-27	35	19	self	self	NOUN
cbi-27	35	20	-	-	PUNCT
cbi-27	35	21	assemble	assemble	VERB
cbi-27	35	22	itself	itself	PRON
cbi-27	35	23	in	in	ADP
cbi-27	35	24	each	each	DET
cbi-27	35	25	life	life	NOUN
cbi-27	35	26	cycle	cycle	NOUN
cbi-27	35	27	with	with	ADP
cbi-27	35	28	the	the	DET
cbi-27	35	29	potential	potential	NOUN
cbi-27	35	30	to	to	PART
cbi-27	35	31	add	add	VERB
cbi-27	35	32	new	new	ADJ
cbi-27	35	33	functionality	functionality	NOUN
cbi-27	35	34	on	on	ADP
cbi-27	35	35	top	top	NOUN
cbi-27	35	36	of	of	ADP
cbi-27	35	37	the	the	DET
cbi-27	35	38	existing	exist	VERB
cbi-27	35	39	functionality	functionality	NOUN
cbi-27	35	40	.	.	PUNCT
cbi-27	36	1	since	since	SCONJ
cbi-27	36	2	the	the	DET
cbi-27	36	3	blueprint	blueprint	NOUN
cbi-27	36	4	of	of	ADP
cbi-27	36	5	the	the	DET
cbi-27	36	6	self	self	NOUN
cbi-27	36	7	-	-	PUNCT
cbi-27	36	8	assembly	assembly	NOUN
cbi-27	36	9	is	be	AUX
cbi-27	36	10	contained	contain	VERB
cbi-27	36	11	in	in	ADP
cbi-27	36	12	the	the	DET
cbi-27	36	13	genome	genome	NOUN
cbi-27	36	14	(	(	PUNCT
cbi-27	36	15	dna	dna	PROPN
cbi-27	36	16	)	)	PUNCT
cbi-27	36	17	,	,	PUNCT
cbi-27	36	18	the	the	DET
cbi-27	36	19	expansion	expansion	NOUN
cbi-27	36	20	of	of	ADP
cbi-27	36	21	the	the	DET
cbi-27	36	22	blueprint	blueprint	NOUN
cbi-27	36	23	in	in	ADP
cbi-27	36	24	time	time	NOUN
cbi-27	36	25	is	be	AUX
cbi-27	36	26	what	what	PRON
cbi-27	36	27	we	we	PRON
cbi-27	36	28	call	call	VERB
cbi-27	36	29	evolution	evolution	NOUN
cbi-27	36	30	.	.	PUNCT
cbi-27	37	1	1.6	1.6	NUM
cbi-27	37	2	the	the	DET
cbi-27	37	3	software	software	NOUN
cbi-27	37	4	development	development	NOUN
cbi-27	37	5	life	life	NOUN
cbi-27	37	6	cycle	cycle	NOUN
cbi-27	37	7	we	we	PRON
cbi-27	37	8	can	can	AUX
cbi-27	37	9	compare	compare	VERB
cbi-27	37	10	the	the	DET
cbi-27	37	11	stepwise	stepwise	ADJ
cbi-27	37	12	evolution	evolution	NOUN
cbi-27	37	13	of	of	ADP
cbi-27	37	14	the	the	DET
cbi-27	37	15	molecular	molecular	ADJ
cbi-27	37	16	machine	machine	NOUN
cbi-27	37	17	we	we	PRON
cbi-27	37	18	call	call	VERB
cbi-27	37	19	life	life	NOUN
cbi-27	37	20	with	with	ADP
cbi-27	37	21	the	the	DET
cbi-27	37	22	step	step	NOUN
cbi-27	37	23	-	-	PUNCT
cbi-27	37	24	wise	wise	ADJ
cbi-27	37	25	development	development	NOUN
cbi-27	37	26	of	of	ADP
cbi-27	37	27	a	a	DET
cbi-27	37	28	software	software	NOUN
cbi-27	37	29	program	program	NOUN
cbi-27	37	30	.	.	PUNCT
cbi-27	38	1	with	with	ADP
cbi-27	38	2	each	each	DET
cbi-27	38	3	cycle	cycle	NOUN
cbi-27	38	4	in	in	ADP
cbi-27	38	5	software	software	NOUN
cbi-27	38	6	development	development	NOUN
cbi-27	38	7	some	some	DET
cbi-27	38	8	extra	extra	ADJ
cbi-27	38	9	programming	programming	NOUN
cbi-27	38	10	for	for	ADP
cbi-27	38	11	new	new	ADJ
cbi-27	38	12	functionality	functionality	NOUN
cbi-27	38	13	is	be	AUX
cbi-27	38	14	done	do	VERB
cbi-27	38	15	resulting	result	VERB
cbi-27	38	16	into	into	ADP
cbi-27	38	17	a	a	DET
cbi-27	38	18	new	new	ADJ
cbi-27	38	19	functional	functional	ADJ
cbi-27	38	20	release	release	NOUN
cbi-27	38	21	.	.	PUNCT
cbi-27	39	1	we	we	PRON
cbi-27	39	2	want	want	VERB
cbi-27	39	3	to	to	PART
cbi-27	39	4	create	create	VERB
cbi-27	39	5	of	of	ADP
cbi-27	39	6	system	system	NOUN
cbi-27	39	7	with	with	ADP
cbi-27	39	8	many	many	ADJ
cbi-27	39	9	functional	functional	ADJ
cbi-27	39	10	modules	module	NOUN
cbi-27	39	11	that	that	PRON
cbi-27	39	12	has	have	AUX
cbi-27	39	13	evolved	evolve	VERB
cbi-27	39	14	from	from	ADP
cbi-27	39	15	previous	previous	ADJ
cbi-27	39	16	less	less	ADV
cbi-27	39	17	complex	complex	ADJ
cbi-27	39	18	stages	stage	NOUN
cbi-27	39	19	.	.	PUNCT
cbi-27	40	1	if	if	SCONJ
cbi-27	40	2	we	we	PRON
cbi-27	40	3	model	model	VERB
cbi-27	40	4	evolution	evolution	NOUN
cbi-27	40	5	on	on	ADP
cbi-27	40	6	building	building	NOUN
cbi-27	40	7	software	software	NOUN
cbi-27	40	8	,	,	PUNCT
cbi-27	40	9	we	we	PRON
cbi-27	40	10	would	would	AUX
cbi-27	40	11	start	start	VERB
cbi-27	40	12	with	with	ADP
cbi-27	40	13	some	some	DET
cbi-27	40	14	simple	simple	ADJ
cbi-27	40	15	code	code	NOUN
cbi-27	40	16	that	that	PRON
cbi-27	40	17	creates	create	VERB
cbi-27	40	18	a	a	DET
cbi-27	40	19	program	program	NOUN
cbi-27	40	20	but	but	CCONJ
cbi-27	40	21	that	that	SCONJ
cbi-27	40	22	we	we	PRON
cbi-27	40	23	build	build	VERB
cbi-27	40	24	incrementally	incrementally	ADV
cbi-27	40	25	.	.	PUNCT
cbi-27	41	1	with	with	ADP
cbi-27	41	2	each	each	DET
cbi-27	41	3	software	software	NOUN
cbi-27	41	4	cycle	cycle	NOUN
cbi-27	41	5	we	we	PRON
cbi-27	41	6	would	would	AUX
cbi-27	41	7	create	create	VERB
cbi-27	41	8	a	a	DET
cbi-27	41	9	working	work	VERB
cbi-27	41	10	product	product	NOUN
cbi-27	41	11	unto	unto	ADP
cbi-27	41	12	which	which	PRON
cbi-27	41	13	to	to	PART
cbi-27	41	14	build	build	VERB
cbi-27	41	15	further	far	ADV
cbi-27	41	16	and	and	CCONJ
cbi-27	41	17	each	each	DET
cbi-27	41	18	iteration	iteration	NOUN
cbi-27	41	19	of	of	ADP
cbi-27	41	20	the	the	DET
cbi-27	41	21	software	software	NOUN
cbi-27	41	22	should	should	AUX
cbi-27	41	23	be	be	AUX
cbi-27	41	24	fully	fully	ADV
cbi-27	41	25	functional	functional	ADJ
cbi-27	41	26	.	.	PUNCT
cbi-27	42	1	in	in	ADP
cbi-27	42	2	software	software	NOUN
cbi-27	42	3	development	development	NOUN
cbi-27	42	4	,	,	PUNCT
cbi-27	42	5	we	we	PRON
cbi-27	42	6	work	work	VERB
cbi-27	42	7	with	with	ADP
cbi-27	42	8	concrete	concrete	ADJ
cbi-27	42	9	design	design	NOUN
cbi-27	42	10	and	and	CCONJ
cbi-27	42	11	design	design	NOUN
cbi-27	42	12	patterns	pattern	NOUN
cbi-27	42	13	in	in	ADP
cbi-27	42	14	order	order	NOUN
cbi-27	42	15	to	to	PART
cbi-27	42	16	build	build	VERB
cbi-27	42	17	complex	complex	ADJ
cbi-27	42	18	software	software	NOUN
cbi-27	42	19	systems	system	NOUN
cbi-27	42	20	that	that	PRON
cbi-27	42	21	continue	continue	VERB
cbi-27	42	22	to	to	PART
cbi-27	42	23	keep	keep	VERB
cbi-27	42	24	working	work	VERB
cbi-27	42	25	with	with	ADP
cbi-27	42	26	increasing	increase	VERB
cbi-27	42	27	complexity	complexity	NOUN
cbi-27	42	28	.	.	PUNCT
cbi-27	43	1	in	in	ADP
cbi-27	43	2	order	order	NOUN
cbi-27	43	3	to	to	PART
cbi-27	43	4	use	use	VERB
cbi-27	43	5	the	the	DET
cbi-27	43	6	analogy	analogy	NOUN
cbi-27	43	7	of	of	ADP
cbi-27	43	8	software	software	NOUN
cbi-27	43	9	design	design	NOUN
cbi-27	43	10	to	to	ADP
cbi-27	43	11	evolution	evolution	NOUN
cbi-27	43	12	,	,	PUNCT
cbi-27	43	13	we	we	PRON
cbi-27	43	14	have	have	VERB
cbi-27	43	15	to	to	PART
cbi-27	43	16	specify	specify	VERB
cbi-27	43	17	a	a	DET
cbi-27	43	18	similar	similar	ADJ
cbi-27	43	19	framework	framework	NOUN
cbi-27	43	20	or	or	CCONJ
cbi-27	43	21	model	model	NOUN
cbi-27	43	22	that	that	PRON
cbi-27	43	23	will	will	AUX
cbi-27	43	24	represent	represent	VERB
cbi-27	43	25	evolution	evolution	NOUN
cbi-27	43	26	.	.	PUNCT
cbi-27	44	1	1.7	1.7	NUM
cbi-27	44	2	a	a	DET
cbi-27	44	3	concrete	concrete	ADJ
cbi-27	44	4	design	design	NOUN
cbi-27	44	5	paradigm	paradigm	NOUN
cbi-27	44	6	for	for	ADP
cbi-27	44	7	evolution	evolution	NOUN
cbi-27	44	8	the	the	DET
cbi-27	44	9	basic	basic	ADJ
cbi-27	44	10	premise	premise	NOUN
cbi-27	44	11	in	in	ADP
cbi-27	44	12	this	this	DET
cbi-27	44	13	article	article	NOUN
cbi-27	44	14	is	be	AUX
cbi-27	44	15	that	that	SCONJ
cbi-27	44	16	a	a	DET
cbi-27	44	17	design	design	NOUN
cbi-27	44	18	framework	framework	NOUN
cbi-27	44	19	similar	similar	ADJ
cbi-27	44	20	to	to	ADP
cbi-27	44	21	the	the	DET
cbi-27	44	22	concepts	concept	NOUN
cbi-27	44	23	used	use	VERB
cbi-27	44	24	in	in	ADP
cbi-27	44	25	engineering	engineering	NOUN
cbi-27	44	26	and	and	CCONJ
cbi-27	44	27	exemplified	exemplify	VERB
cbi-27	44	28	in	in	ADP
cbi-27	44	29	complex	complex	ADJ
cbi-27	44	30	it	it	PRON
cbi-27	44	31	-	-	PUNCT
cbi-27	44	32	systems	system	NOUN
cbi-27	44	33	and	and	CCONJ
cbi-27	44	34	software	software	NOUN
cbi-27	44	35	development	development	NOUN
cbi-27	44	36	can	can	AUX
cbi-27	44	37	be	be	AUX
cbi-27	44	38	used	use	VERB
cbi-27	44	39	to	to	PART
cbi-27	44	40	model	model	VERB
cbi-27	44	41	evolution	evolution	NOUN
cbi-27	44	42	.	.	PUNCT
cbi-27	45	1	the	the	DET
cbi-27	45	2	working	work	VERB
cbi-27	45	3	hypothesis	hypothesis	NOUN
cbi-27	45	4	in	in	ADP
cbi-27	45	5	the	the	DET
cbi-27	45	6	research	research	NOUN
cbi-27	45	7	presented	present	VERB
cbi-27	45	8	here	here	ADV
cbi-27	45	9	is	be	AUX
cbi-27	45	10	that	that	SCONJ
cbi-27	45	11	evolution	evolution	NOUN
cbi-27	45	12	can	can	AUX
cbi-27	45	13	be	be	AUX
cbi-27	45	14	modeled	model	VERB
cbi-27	45	15	on	on	ADP
cbi-27	45	16	the	the	DET
cbi-27	45	17	software	software	NOUN
cbi-27	45	18	design	design	NOUN
cbi-27	45	19	methodology	methodology	NOUN
cbi-27	45	20	’	'	PUNCT
cbi-27	45	21	design	design	NOUN
cbi-27	45	22	-	-	PUNCT
cbi-27	45	23	by	by	ADP
cbi-27	45	24	-	-	PUNCT
cbi-27	45	25	contract	contract	NOUN
cbi-27	45	26	’	'	PUNCT
cbi-27	45	27	,	,	PUNCT
cbi-27	45	28	the	the	DET
cbi-27	45	29	basic	basic	ADJ
cbi-27	45	30	design	design	NOUN
cbi-27	45	31	underlying	underlie	VERB
cbi-27	45	32	complex	complex	ADJ
cbi-27	45	33	software	software	NOUN
cbi-27	45	34	systems	system	NOUN
cbi-27	45	35	.	.	PUNCT
cbi-27	46	1	a	a	DET
cbi-27	46	2	strict	strict	ADJ
cbi-27	46	3	implementation	implementation	NOUN
cbi-27	46	4	of	of	ADP
cbi-27	46	5	design	design	NOUN
cbi-27	46	6	-	-	PUNCT
cbi-27	46	7	by	by	ADP
cbi-27	46	8	-	-	PUNCT
cbi-27	46	9	contract	contract	NOUN
cbi-27	46	10	is	be	AUX
cbi-27	46	11	enforced	enforce	VERB
cbi-27	46	12	by	by	ADP
cbi-27	46	13	the	the	DET
cbi-27	46	14	condition	condition	NOUN
cbi-27	46	15	that	that	SCONJ
cbi-27	46	16	earlier	early	ADJ
cbi-27	46	17	’	'	PUNCT
cbi-27	46	18	contracts	contract	NOUN
cbi-27	46	19	’	'	PUNCT
cbi-27	46	20	must	must	AUX
cbi-27	46	21	always	always	ADV
cbi-27	46	22	be	be	AUX
cbi-27	46	23	respected	respect	VERB
cbi-27	46	24	otherwise	otherwise	ADV
cbi-27	46	25	the	the	DET
cbi-27	46	26	premise	premise	NOUN
cbi-27	46	27	of	of	ADP
cbi-27	46	28	functional	functional	ADJ
cbi-27	46	29	continuity	continuity	NOUN
cbi-27	46	30	will	will	AUX
cbi-27	46	31	be	be	AUX
cbi-27	46	32	breached	breach	VERB
cbi-27	46	33	.	.	PUNCT
cbi-27	47	1	evolution	evolution	NOUN
cbi-27	47	2	of	of	ADP
cbi-27	47	3	such	such	DET
cbi-27	47	4	a	a	DET
cbi-27	47	5	system	system	NOUN
cbi-27	47	6	can	can	AUX
cbi-27	47	7	then	then	ADV
cbi-27	47	8	take	take	VERB
cbi-27	47	9	place	place	NOUN
cbi-27	47	10	in	in	ADP
cbi-27	47	11	different	different	ADJ
cbi-27	47	12	manners	manner	NOUN
cbi-27	47	13	for	for	ADP
cbi-27	47	14	instance	instance	NOUN
cbi-27	47	15	by	by	ADP
cbi-27	47	16	the	the	DET
cbi-27	47	17	creation	creation	NOUN
cbi-27	47	18	of	of	ADP
cbi-27	47	19	completely	completely	ADV
cbi-27	47	20	new	new	ADJ
cbi-27	47	21	functional	functional	ADJ
cbi-27	47	22	modules	module	NOUN
cbi-27	47	23	build	build	VERB
cbi-27	47	24	on	on	ADP
cbi-27	47	25	top	top	NOUN
cbi-27	47	26	of	of	ADP
cbi-27	47	27	others	other	NOUN
cbi-27	47	28	,	,	PUNCT
cbi-27	47	29	or	or	CCONJ
cbi-27	47	30	by	by	ADP
cbi-27	47	31	hierarchical	hierarchical	ADJ
cbi-27	47	32	extension	extension	NOUN
cbi-27	47	33	of	of	ADP
cbi-27	47	34	existing	exist	VERB
cbi-27	47	35	interfaces	interface	NOUN
cbi-27	47	36	.	.	PUNCT
cbi-27	48	1	based	base	VERB
cbi-27	48	2	on	on	ADP
cbi-27	48	3	the	the	DET
cbi-27	48	4	same	same	ADJ
cbi-27	48	5	requirements	requirement	NOUN
cbi-27	48	6	,	,	PUNCT
cbi-27	48	7	basically	basically	ADV
cbi-27	48	8	functional	functional	ADJ
cbi-27	48	9	continuity	continuity	NOUN
cbi-27	48	10	in	in	ADP
cbi-27	48	11	evolving	evolve	VERB
cbi-27	48	12	systems	system	NOUN
cbi-27	48	13	,	,	PUNCT
cbi-27	48	14	the	the	DET
cbi-27	48	15	concrete	concrete	ADJ
cbi-27	48	16	design	design	NOUN
cbi-27	48	17	patterns	pattern	NOUN
cbi-27	48	18	used	use	VERB
cbi-27	48	19	in	in	ADP
cbi-27	48	20	software	software	NOUN
cbi-27	48	21	development	development	NOUN
cbi-27	48	22	can	can	AUX
cbi-27	48	23	therefore	therefore	ADV
cbi-27	48	24	also	also	ADV
cbi-27	48	25	be	be	AUX
cbi-27	48	26	used	use	VERB
cbi-27	48	27	for	for	ADP
cbi-27	48	28	modeling	model	VERB
cbi-27	48	29	evolution	evolution	NOUN
cbi-27	48	30	.	.	PUNCT
cbi-27	49	1	2	2	NUM
cbi-27	49	2	software	software	NOUN
cbi-27	49	3	design	design	NOUN
cbi-27	49	4	patterns	pattern	NOUN
cbi-27	49	5	there	there	PRON
cbi-27	49	6	are	be	VERB
cbi-27	49	7	many	many	ADJ
cbi-27	49	8	similarities	similarity	NOUN
cbi-27	49	9	between	between	ADP
cbi-27	49	10	software	software	NOUN
cbi-27	49	11	design	design	NOUN
cbi-27	49	12	and	and	CCONJ
cbi-27	49	13	evolution	evolution	NOUN
cbi-27	49	14	.	.	PUNCT
cbi-27	50	1	except	except	SCONJ
cbi-27	50	2	for	for	ADP
cbi-27	50	3	a	a	DET
cbi-27	50	4	more	more	ADV
cbi-27	50	5	general	general	ADJ
cbi-27	50	6	architecture	architecture	NOUN
cbi-27	50	7	of	of	ADP
cbi-27	50	8	incremental	incremental	ADJ
cbi-27	50	9	development	development	NOUN
cbi-27	50	10	as	as	SCONJ
cbi-27	50	11	we	we	PRON
cbi-27	50	12	have	have	AUX
cbi-27	50	13	seen	see	VERB
cbi-27	50	14	as	as	ADP
cbi-27	50	15	the	the	DET
cbi-27	50	16	basic	basic	ADJ
cbi-27	50	17	principle	principle	NOUN
cbi-27	50	18	behind	behind	ADP
cbi-27	50	19	evolution	evolution	NOUN
cbi-27	50	20	,	,	PUNCT
cbi-27	50	21	several	several	ADJ
cbi-27	50	22	design	design	NOUN
cbi-27	50	23	patterns	pattern	NOUN
cbi-27	50	24	that	that	PRON
cbi-27	50	25	are	be	AUX
cbi-27	50	26	relevant	relevant	ADJ
cbi-27	50	27	for	for	ADP
cbi-27	50	28	evolution	evolution	NOUN
cbi-27	50	29	can	can	AUX
cbi-27	50	30	also	also	ADV
cbi-27	50	31	be	be	AUX
cbi-27	50	32	discerned	discern	VERB
cbi-27	50	33	in	in	ADP
cbi-27	50	34	software	software	NOUN
cbi-27	50	35	development	development	NOUN
cbi-27	50	36	.	.	PUNCT
cbi-27	51	1	here	here	ADV
cbi-27	51	2	,	,	PUNCT
cbi-27	51	3	some	some	PRON
cbi-27	51	4	of	of	ADP
cbi-27	51	5	them	they	PRON
cbi-27	51	6	are	be	AUX
cbi-27	51	7	described	describe	VERB
cbi-27	51	8	.	.	PUNCT
cbi-27	52	1	mostly	mostly	ADV
cbi-27	52	2	,	,	PUNCT
cbi-27	52	3	they	they	PRON
cbi-27	52	4	represent	represent	VERB
cbi-27	52	5	common	common	ADJ
cbi-27	52	6	patterns	pattern	NOUN
cbi-27	52	7	in	in	ADP
cbi-27	52	8	engineering	engineering	NOUN
cbi-27	52	9	that	that	PRON
cbi-27	52	10	are	be	AUX
cbi-27	52	11	formally	formally	ADV
cbi-27	52	12	conceptualized	conceptualize	VERB
cbi-27	52	13	in	in	ADP
cbi-27	52	14	software	software	NOUN
cbi-27	52	15	design	design	NOUN
cbi-27	52	16	.	.	PUNCT
cbi-27	53	1	2.1	2.1	NUM
cbi-27	53	2	modularity	modularity	NOUN
cbi-27	53	3	in	in	ADP
cbi-27	53	4	many	many	ADJ
cbi-27	53	5	ways	way	NOUN
cbi-27	53	6	,	,	PUNCT
cbi-27	53	7	the	the	DET
cbi-27	53	8	requirements	requirement	NOUN
cbi-27	53	9	for	for	ADP
cbi-27	53	10	the	the	DET
cbi-27	53	11	evolution	evolution	NOUN
cbi-27	53	12	of	of	ADP
cbi-27	53	13	life	life	NOUN
cbi-27	53	14	are	be	AUX
cbi-27	53	15	similar	similar	ADJ
cbi-27	53	16	to	to	ADP
cbi-27	53	17	those	those	PRON
cbi-27	53	18	of	of	ADP
cbi-27	53	19	modern	modern	ADJ
cbi-27	53	20	software	software	NOUN
cbi-27	53	21	design	design	NOUN
cbi-27	53	22	.	.	PUNCT
cbi-27	54	1	software	software	NOUN
cbi-27	54	2	systems	system	NOUN
cbi-27	54	3	often	often	ADV
cbi-27	54	4	start	start	VERB
cbi-27	54	5	small	small	ADJ
cbi-27	54	6	but	but	CCONJ
cbi-27	54	7	soon	soon	ADV
cbi-27	54	8	extra	extra	ADJ
cbi-27	54	9	functions	function	NOUN
cbi-27	54	10	are	be	AUX
cbi-27	54	11	needed	need	VERB
cbi-27	54	12	volume	volume	NOUN
cbi-27	54	13	1	1	NUM
cbi-27	54	14	,	,	PUNCT
cbi-27	54	15	issue	issue	NOUN
cbi-27	54	16	1	1	NUM
cbi-27	54	17	3	3	NUM
cbi-27	54	18	.	.	PUNCT
cbi-27	55	1	the	the	DET
cbi-27	55	2	origin	origin	NOUN
cbi-27	55	3	of	of	ADP
cbi-27	55	4	life	life	NOUN
cbi-27	55	5	7	7	NUM
cbi-27	55	6	or	or	CCONJ
cbi-27	55	7	existing	exist	VERB
cbi-27	55	8	ones	one	NOUN
cbi-27	55	9	need	need	VERB
cbi-27	55	10	to	to	PART
cbi-27	55	11	be	be	AUX
cbi-27	55	12	changed	change	VERB
cbi-27	55	13	.	.	PUNCT
cbi-27	56	1	as	as	SCONJ
cbi-27	56	2	the	the	DET
cbi-27	56	3	system	system	NOUN
cbi-27	56	4	grows	grow	VERB
cbi-27	56	5	by	by	ADP
cbi-27	56	6	adding	add	VERB
cbi-27	56	7	new	new	ADJ
cbi-27	56	8	functions	function	NOUN
cbi-27	56	9	,	,	PUNCT
cbi-27	56	10	it	it	PRON
cbi-27	56	11	becomes	become	VERB
cbi-27	56	12	more	more	ADV
cbi-27	56	13	and	and	CCONJ
cbi-27	56	14	more	more	ADV
cbi-27	56	15	difficult	difficult	ADJ
cbi-27	56	16	to	to	PART
cbi-27	56	17	change	change	VERB
cbi-27	56	18	the	the	DET
cbi-27	56	19	system	system	NOUN
cbi-27	56	20	.	.	PUNCT
cbi-27	57	1	changes	change	NOUN
cbi-27	57	2	in	in	ADP
cbi-27	57	3	one	one	NUM
cbi-27	57	4	part	part	NOUN
cbi-27	57	5	may	may	AUX
cbi-27	57	6	have	have	VERB
cbi-27	57	7	an	an	DET
cbi-27	57	8	effect	effect	NOUN
cbi-27	57	9	on	on	ADP
cbi-27	57	10	other	other	ADJ
cbi-27	57	11	parts	part	NOUN
cbi-27	57	12	and	and	CCONJ
cbi-27	57	13	can	can	AUX
cbi-27	57	14	therefore	therefore	ADV
cbi-27	57	15	have	have	VERB
cbi-27	57	16	unintended	unintended	ADJ
cbi-27	57	17	consequences	consequence	NOUN
cbi-27	57	18	.	.	PUNCT
cbi-27	58	1	this	this	PRON
cbi-27	58	2	makes	make	VERB
cbi-27	58	3	that	that	SCONJ
cbi-27	58	4	we	we	PRON
cbi-27	58	5	want	want	VERB
cbi-27	58	6	to	to	PART
cbi-27	58	7	have	have	VERB
cbi-27	58	8	a	a	DET
cbi-27	58	9	system	system	NOUN
cbi-27	58	10	that	that	PRON
cbi-27	58	11	is	be	AUX
cbi-27	58	12	robust	robust	ADJ
cbi-27	58	13	yet	yet	ADV
cbi-27	58	14	flexible	flexible	ADJ
cbi-27	58	15	.	.	PUNCT
cbi-27	59	1	in	in	ADP
cbi-27	59	2	computer	computer	NOUN
cbi-27	59	3	science	science	NOUN
cbi-27	59	4	,	,	PUNCT
cbi-27	59	5	these	these	DET
cbi-27	59	6	requirements	requirement	NOUN
cbi-27	59	7	are	be	AUX
cbi-27	59	8	usually	usually	ADV
cbi-27	59	9	implemented	implement	VERB
cbi-27	59	10	by	by	ADP
cbi-27	59	11	having	have	VERB
cbi-27	59	12	modular	modular	ADJ
cbi-27	59	13	design	design	NOUN
cbi-27	59	14	in	in	ADP
cbi-27	59	15	which	which	PRON
cbi-27	59	16	function	function	NOUN
cbi-27	59	17	al	al	PROPN
cbi-27	59	18	modules	module	NOUN
cbi-27	59	19	communicate	communicate	VERB
cbi-27	59	20	with	with	ADP
cbi-27	59	21	each	each	DET
cbi-27	59	22	other	other	ADJ
cbi-27	59	23	through	through	ADP
cbi-27	59	24	interfaces	interface	NOUN
cbi-27	59	25	.	.	PUNCT
cbi-27	60	1	by	by	ADP
cbi-27	60	2	hiding	hide	VERB
cbi-27	60	3	the	the	DET
cbi-27	60	4	complexity	complexity	NOUN
cbi-27	60	5	within	within	ADP
cbi-27	60	6	each	each	DET
cbi-27	60	7	module	module	NOUN
cbi-27	60	8	,	,	PUNCT
cbi-27	60	9	we	we	PRON
cbi-27	60	10	can	can	AUX
cbi-27	60	11	reduce	reduce	VERB
cbi-27	60	12	the	the	DET
cbi-27	60	13	overall	overall	ADJ
cbi-27	60	14	complexity	complexity	NOUN
cbi-27	60	15	of	of	ADP
cbi-27	60	16	the	the	DET
cbi-27	60	17	system	system	NOUN
cbi-27	60	18	.	.	PUNCT
cbi-27	61	1	modularity	modularity	NOUN
cbi-27	61	2	is	be	AUX
cbi-27	61	3	something	something	PRON
cbi-27	61	4	we	we	PRON
cbi-27	61	5	also	also	ADV
cbi-27	61	6	expect	expect	VERB
cbi-27	61	7	in	in	ADP
cbi-27	61	8	evolution	evolution	NOUN
cbi-27	61	9	as	as	SCONJ
cbi-27	61	10	it	it	PRON
cbi-27	61	11	allows	allow	VERB
cbi-27	61	12	independent	independent	ADJ
cbi-27	61	13	evolution	evolution	NOUN
cbi-27	61	14	of	of	ADP
cbi-27	61	15	subparts	subpart	NOUN
cbi-27	61	16	.	.	PUNCT
cbi-27	62	1	2.2	2.2	NUM
cbi-27	62	2	system	system	NOUN
cbi-27	62	3	expansion	expansion	NOUN
cbi-27	62	4	through	through	ADP
cbi-27	62	5	design	design	NOUN
cbi-27	62	6	-	-	PUNCT
cbi-27	62	7	by	by	ADP
cbi-27	62	8	-	-	PUNCT
cbi-27	62	9	contract	contract	NOUN
cbi-27	62	10	the	the	DET
cbi-27	62	11	problems	problem	NOUN
cbi-27	62	12	of	of	ADP
cbi-27	62	13	increasing	increase	VERB
cbi-27	62	14	complexity	complexity	NOUN
cbi-27	62	15	in	in	ADP
cbi-27	62	16	a	a	DET
cbi-27	62	17	system	system	NOUN
cbi-27	62	18	that	that	PRON
cbi-27	62	19	needs	need	VERB
cbi-27	62	20	to	to	PART
cbi-27	62	21	be	be	AUX
cbi-27	62	22	robust	robust	ADJ
cbi-27	62	23	,	,	PUNCT
cbi-27	62	24	flexible	flexible	ADJ
cbi-27	62	25	and	and	CCONJ
cbi-27	62	26	resilient	resilient	ADJ
cbi-27	62	27	have	have	AUX
cbi-27	62	28	been	be	AUX
cbi-27	62	29	addressed	address	VERB
cbi-27	62	30	in	in	ADP
cbi-27	62	31	software	software	NOUN
cbi-27	62	32	development	development	NOUN
cbi-27	62	33	by	by	ADP
cbi-27	62	34	using	use	VERB
cbi-27	62	35	the	the	DET
cbi-27	62	36	design	design	NOUN
cbi-27	62	37	-	-	PUNCT
cbi-27	62	38	bycontract	bycontract	NOUN
cbi-27	62	39	methodology	methodology	NOUN
cbi-27	62	40	.	.	PUNCT
cbi-27	63	1	it	it	PRON
cbi-27	63	2	works	work	VERB
cbi-27	63	3	by	by	ADP
cbi-27	63	4	dividing	divide	VERB
cbi-27	63	5	the	the	DET
cbi-27	63	6	system	system	NOUN
cbi-27	63	7	in	in	ADP
cbi-27	63	8	functional	functional	ADJ
cbi-27	63	9	modules	module	NOUN
cbi-27	63	10	that	that	PRON
cbi-27	63	11	communicate	communicate	VERB
cbi-27	63	12	with	with	ADP
cbi-27	63	13	each	each	DET
cbi-27	63	14	other	other	ADJ
cbi-27	63	15	in	in	ADP
cbi-27	63	16	a	a	DET
cbi-27	63	17	specified	specified	ADJ
cbi-27	63	18	way	way	NOUN
cbi-27	63	19	,	,	PUNCT
cbi-27	63	20	a	a	DET
cbi-27	63	21	sort	sort	NOUN
cbi-27	63	22	of	of	ADP
cbi-27	63	23	contract	contract	NOUN
cbi-27	63	24	that	that	SCONJ
cbi-27	63	25	both	both	DET
cbi-27	63	26	parties	party	NOUN
cbi-27	63	27	need	need	VERB
cbi-27	63	28	to	to	PART
cbi-27	63	29	adhere	adhere	VERB
cbi-27	63	30	to	to	ADP
cbi-27	63	31	.	.	PUNCT
cbi-27	64	1	the	the	DET
cbi-27	64	2	only	only	ADJ
cbi-27	64	3	thing	thing	NOUN
cbi-27	64	4	a	a	DET
cbi-27	64	5	module	module	NOUN
cbi-27	64	6	has	have	VERB
cbi-27	64	7	to	to	PART
cbi-27	64	8	know	know	VERB
cbi-27	64	9	about	about	ADP
cbi-27	64	10	other	other	ADJ
cbi-27	64	11	parts	part	NOUN
cbi-27	64	12	of	of	ADP
cbi-27	64	13	the	the	DET
cbi-27	64	14	system	system	NOUN
cbi-27	64	15	is	be	AUX
cbi-27	64	16	through	through	ADP
cbi-27	64	17	this	this	DET
cbi-27	64	18	interface	interface	NOUN
cbi-27	64	19	and	and	CCONJ
cbi-27	64	20	as	as	ADV
cbi-27	64	21	long	long	ADV
cbi-27	64	22	as	as	SCONJ
cbi-27	64	23	you	you	PRON
cbi-27	64	24	do	do	AUX
cbi-27	64	25	not	not	PART
cbi-27	64	26	change	change	VERB
cbi-27	64	27	the	the	DET
cbi-27	64	28	way	way	NOUN
cbi-27	64	29	you	you	PRON
cbi-27	64	30	communicate	communicate	VERB
cbi-27	64	31	,	,	PUNCT
cbi-27	64	32	each	each	DET
cbi-27	64	33	function	function	NOUN
cbi-27	64	34	can	can	AUX
cbi-27	64	35	evolve	evolve	VERB
cbi-27	64	36	independently	independently	ADV
cbi-27	64	37	.	.	PUNCT
cbi-27	65	1	the	the	DET
cbi-27	65	2	reason	reason	NOUN
cbi-27	65	3	that	that	PRON
cbi-27	65	4	established	establish	VERB
cbi-27	65	5	interfaces	interface	NOUN
cbi-27	65	6	can	can	AUX
cbi-27	65	7	not	not	PART
cbi-27	65	8	be	be	AUX
cbi-27	65	9	changed	change	VERB
cbi-27	65	10	is	be	AUX
cbi-27	65	11	because	because	SCONJ
cbi-27	65	12	downstream	downstream	ADJ
cbi-27	65	13	processes	process	NOUN
cbi-27	65	14	rely	rely	VERB
cbi-27	65	15	on	on	ADP
cbi-27	65	16	that	that	DET
cbi-27	65	17	interface	interface	NOUN
cbi-27	65	18	.	.	PUNCT
cbi-27	66	1	if	if	SCONJ
cbi-27	66	2	you	you	PRON
cbi-27	66	3	change	change	VERB
cbi-27	66	4	them	they	PRON
cbi-27	66	5	,	,	PUNCT
cbi-27	66	6	all	all	DET
cbi-27	66	7	processes	process	NOUN
cbi-27	66	8	that	that	PRON
cbi-27	66	9	are	be	AUX
cbi-27	66	10	dependent	dependent	ADJ
cbi-27	66	11	on	on	ADP
cbi-27	66	12	it	it	PRON
cbi-27	66	13	,	,	PUNCT
cbi-27	66	14	may	may	AUX
cbi-27	66	15	not	not	PART
cbi-27	66	16	work	work	VERB
cbi-27	66	17	anymore	anymore	ADV
cbi-27	66	18	.	.	PUNCT
cbi-27	67	1	for	for	ADP
cbi-27	67	2	evolution	evolution	NOUN
cbi-27	67	3	that	that	PRON
cbi-27	67	4	we	we	PRON
cbi-27	67	5	also	also	ADV
cbi-27	67	6	see	see	VERB
cbi-27	67	7	as	as	ADP
cbi-27	67	8	an	an	DET
cbi-27	67	9	expanding	expand	VERB
cbi-27	67	10	system	system	NOUN
cbi-27	67	11	of	of	ADP
cbi-27	67	12	functionalities	functionality	NOUN
cbi-27	67	13	,	,	PUNCT
cbi-27	67	14	it	it	PRON
cbi-27	67	15	means	mean	VERB
cbi-27	67	16	that	that	SCONJ
cbi-27	67	17	all	all	DET
cbi-27	67	18	processes	process	NOUN
cbi-27	67	19	or	or	CCONJ
cbi-27	67	20	functional	functional	ADJ
cbi-27	67	21	modules	module	NOUN
cbi-27	67	22	that	that	PRON
cbi-27	67	23	are	be	AUX
cbi-27	67	24	added	add	VERB
cbi-27	67	25	later	later	ADV
cbi-27	67	26	in	in	ADP
cbi-27	67	27	evolution	evolution	NOUN
cbi-27	67	28	will	will	AUX
cbi-27	67	29	be	be	AUX
cbi-27	67	30	dependent	dependent	ADJ
cbi-27	67	31	on	on	ADP
cbi-27	67	32	earlier	early	ADJ
cbi-27	67	33	interface	interface	NOUN
cbi-27	67	34	and	and	CCONJ
cbi-27	67	35	therefore	therefore	ADV
cbi-27	67	36	difficult	difficult	ADJ
cbi-27	67	37	to	to	PART
cbi-27	67	38	change	change	VERB
cbi-27	67	39	.	.	PUNCT
cbi-27	68	1	2.3	2.3	NUM
cbi-27	68	2	encapsulation	encapsulation	NOUN
cbi-27	68	3	in	in	ADP
cbi-27	68	4	software	software	NOUN
cbi-27	68	5	design	design	NOUN
cbi-27	68	6	,	,	PUNCT
cbi-27	68	7	the	the	DET
cbi-27	68	8	term	term	NOUN
cbi-27	68	9	encapsulation	encapsulation	NOUN
cbi-27	68	10	is	be	AUX
cbi-27	68	11	used	use	VERB
cbi-27	68	12	when	when	SCONJ
cbi-27	68	13	a	a	DET
cbi-27	68	14	functional	functional	ADJ
cbi-27	68	15	layer	layer	NOUN
cbi-27	68	16	is	be	AUX
cbi-27	68	17	added	add	VERB
cbi-27	68	18	as	as	ADP
cbi-27	68	19	a	a	DET
cbi-27	68	20	layer	layer	NOUN
cbi-27	68	21	on	on	ADP
cbi-27	68	22	top	top	NOUN
cbi-27	68	23	of	of	ADP
cbi-27	68	24	the	the	DET
cbi-27	68	25	old	old	ADJ
cbi-27	68	26	layer	layer	NOUN
cbi-27	68	27	without	without	ADP
cbi-27	68	28	replacing	replace	VERB
cbi-27	68	29	the	the	DET
cbi-27	68	30	old	old	ADJ
cbi-27	68	31	layer	layer	NOUN
cbi-27	68	32	.	.	PUNCT
cbi-27	69	1	this	this	PRON
cbi-27	69	2	is	be	AUX
cbi-27	69	3	for	for	ADP
cbi-27	69	4	instance	instance	NOUN
cbi-27	69	5	very	very	ADV
cbi-27	69	6	useful	useful	ADJ
cbi-27	69	7	when	when	SCONJ
cbi-27	69	8	dealing	deal	VERB
cbi-27	69	9	with	with	ADP
cbi-27	69	10	legacy	legacy	NOUN
cbi-27	69	11	systems	system	NOUN
cbi-27	69	12	that	that	PRON
cbi-27	69	13	function	function	VERB
cbi-27	69	14	correctly	correctly	ADV
cbi-27	69	15	and	and	CCONJ
cbi-27	69	16	that	that	SCONJ
cbi-27	69	17	we	we	PRON
cbi-27	69	18	do	do	AUX
cbi-27	69	19	not	not	PART
cbi-27	69	20	want	want	VERB
cbi-27	69	21	to	to	PART
cbi-27	69	22	replace	replace	VERB
cbi-27	69	23	.	.	PUNCT
cbi-27	70	1	for	for	ADP
cbi-27	70	2	instance	instance	NOUN
cbi-27	70	3	,	,	PUNCT
cbi-27	70	4	instead	instead	ADV
cbi-27	70	5	of	of	ADP
cbi-27	70	6	using	use	VERB
cbi-27	70	7	the	the	DET
cbi-27	70	8	old	old	ADJ
cbi-27	70	9	command	command	NOUN
cbi-27	70	10	-	-	PUNCT
cbi-27	70	11	line	line	NOUN
cbi-27	70	12	interface	interface	NOUN
cbi-27	70	13	in	in	ADP
cbi-27	70	14	ms	ms	PROPN
cbi-27	70	15	-	-	PUNCT
cbi-27	70	16	dos	do	NOUN
cbi-27	70	17	,	,	PUNCT
cbi-27	70	18	we	we	PRON
cbi-27	70	19	can	can	AUX
cbi-27	70	20	introduce	introduce	VERB
cbi-27	70	21	a	a	DET
cbi-27	70	22	graphical	graphical	ADJ
cbi-27	70	23	windows	window	NOUN
cbi-27	70	24	layer	layer	NOUN
cbi-27	70	25	on	on	ADP
cbi-27	70	26	top	top	NOUN
cbi-27	70	27	that	that	PRON
cbi-27	70	28	will	will	AUX
cbi-27	70	29	translate	translate	VERB
cbi-27	70	30	the	the	DET
cbi-27	70	31	commands	command	NOUN
cbi-27	70	32	for	for	ADP
cbi-27	70	33	us	we	PRON
cbi-27	70	34	.	.	PUNCT
cbi-27	71	1	another	another	DET
cbi-27	71	2	example	example	NOUN
cbi-27	71	3	is	be	AUX
cbi-27	71	4	the	the	DET
cbi-27	71	5	internet	internet	NOUN
cbi-27	71	6	itself	itself	PRON
cbi-27	71	7	that	that	PRON
cbi-27	71	8	uses	use	VERB
cbi-27	71	9	in	in	ADP
cbi-27	71	10	its	its	PRON
cbi-27	71	11	basis	basis	NOUN
cbi-27	71	12	(	(	PUNCT
cbi-27	71	13	and	and	CCONJ
cbi-27	71	14	in	in	ADP
cbi-27	71	15	its	its	PRON
cbi-27	71	16	origin	origin	NOUN
cbi-27	71	17	)	)	PUNCT
cbi-27	71	18	a	a	DET
cbi-27	71	19	simple	simple	ADJ
cbi-27	71	20	protocol	protocol	NOUN
cbi-27	71	21	that	that	PRON
cbi-27	71	22	sends	send	VERB
cbi-27	71	23	binary	binary	ADJ
cbi-27	71	24	data	datum	NOUN
cbi-27	71	25	over	over	ADP
cbi-27	71	26	a	a	DET
cbi-27	71	27	network	network	NOUN
cbi-27	71	28	.	.	PUNCT
cbi-27	72	1	once	once	ADV
cbi-27	72	2	that	that	PRON
cbi-27	72	3	was	be	AUX
cbi-27	72	4	established	establish	VERB
cbi-27	72	5	,	,	PUNCT
cbi-27	72	6	other	other	ADJ
cbi-27	72	7	layers	layer	NOUN
cbi-27	72	8	were	be	AUX
cbi-27	72	9	added	add	VERB
cbi-27	72	10	to	to	PART
cbi-27	72	11	route	route	VERB
cbi-27	72	12	the	the	DET
cbi-27	72	13	data	datum	NOUN
cbi-27	72	14	through	through	ADP
cbi-27	72	15	more	more	ADJ
cbi-27	72	16	complex	complex	ADJ
cbi-27	72	17	networks	network	NOUN
cbi-27	72	18	and	and	CCONJ
cbi-27	72	19	to	to	PART
cbi-27	72	20	give	give	VERB
cbi-27	72	21	instructions	instruction	NOUN
cbi-27	72	22	to	to	ADP
cbi-27	72	23	higher	high	ADJ
cbi-27	72	24	level	level	NOUN
cbi-27	72	25	systems	system	NOUN
cbi-27	72	26	.	.	PUNCT
cbi-27	73	1	thus	thus	ADV
cbi-27	73	2	,	,	PUNCT
cbi-27	73	3	by	by	ADP
cbi-27	73	4	layering	layer	VERB
cbi-27	73	5	functionalities	functionality	NOUN
cbi-27	73	6	on	on	ADP
cbi-27	73	7	top	top	NOUN
cbi-27	73	8	of	of	ADP
cbi-27	73	9	each	each	DET
cbi-27	73	10	other	other	ADJ
cbi-27	73	11	,	,	PUNCT
cbi-27	73	12	we	we	PRON
cbi-27	73	13	can	can	AUX
cbi-27	73	14	create	create	VERB
cbi-27	73	15	complex	complex	ADJ
cbi-27	73	16	systems	system	NOUN
cbi-27	73	17	that	that	PRON
cbi-27	73	18	are	be	AUX
cbi-27	73	19	robust	robust	ADJ
cbi-27	73	20	as	as	ADV
cbi-27	73	21	long	long	ADV
cbi-27	73	22	as	as	SCONJ
cbi-27	73	23	we	we	PRON
cbi-27	73	24	keep	keep	VERB
cbi-27	73	25	existing	exist	VERB
cbi-27	73	26	(	(	PUNCT
cbi-27	73	27	lower	low	ADJ
cbi-27	73	28	level	level	NOUN
cbi-27	73	29	)	)	PUNCT
cbi-27	73	30	interfaces	interface	NOUN
cbi-27	73	31	intact	intact	ADJ
cbi-27	73	32	.	.	PUNCT
cbi-27	74	1	for	for	ADP
cbi-27	74	2	evolution	evolution	NOUN
cbi-27	74	3	,	,	PUNCT
cbi-27	74	4	encapsulation	encapsulation	NOUN
cbi-27	74	5	would	would	AUX
cbi-27	74	6	provide	provide	VERB
cbi-27	74	7	a	a	DET
cbi-27	74	8	way	way	NOUN
cbi-27	74	9	to	to	PART
cbi-27	74	10	keep	keep	VERB
cbi-27	74	11	existing	exist	VERB
cbi-27	74	12	functions	function	NOUN
cbi-27	74	13	by	by	ADP
cbi-27	74	14	wrapping	wrap	VERB
cbi-27	74	15	them	they	PRON
cbi-27	74	16	with	with	ADP
cbi-27	74	17	new	new	ADJ
cbi-27	74	18	,	,	PUNCT
cbi-27	74	19	more	more	ADV
cbi-27	74	20	modern	modern	ADJ
cbi-27	74	21	functionality	functionality	NOUN
cbi-27	74	22	.	.	PUNCT
cbi-27	75	1	legacy	legacy	NOUN
cbi-27	75	2	systemssystem	systemssystem	NOUN
cbi-27	75	3	that	that	PRON
cbi-27	75	4	are	be	AUX
cbi-27	75	5	developed	develop	VERB
cbi-27	75	6	using	use	VERB
cbi-27	75	7	the	the	DET
cbi-27	75	8	designby	designby	NOUN
cbi-27	75	9	-	-	PUNCT
cbi-27	75	10	contract	contract	NOUN
cbi-27	75	11	methodology	methodology	NOUN
cbi-27	75	12	leave	leave	VERB
cbi-27	75	13	older	old	ADJ
cbi-27	75	14	interfaces	interface	NOUN
cbi-27	75	15	intact	intact	ADJ
cbi-27	75	16	causing	cause	VERB
cbi-27	75	17	the	the	DET
cbi-27	75	18	system	system	NOUN
cbi-27	75	19	not	not	PART
cbi-27	75	20	only	only	ADV
cbi-27	75	21	to	to	PART
cbi-27	75	22	be	be	AUX
cbi-27	75	23	robust	robust	ADJ
cbi-27	75	24	but	but	CCONJ
cbi-27	75	25	also	also	ADV
cbi-27	75	26	inflexible	inflexible	ADJ
cbi-27	75	27	.	.	PUNCT
cbi-27	76	1	older	old	ADJ
cbi-27	76	2	parts	part	NOUN
cbi-27	76	3	of	of	ADP
cbi-27	76	4	the	the	DET
cbi-27	76	5	system	system	NOUN
cbi-27	76	6	can	can	AUX
cbi-27	76	7	not	not	PART
cbi-27	76	8	be	be	AUX
cbi-27	76	9	changed	change	VERB
cbi-27	76	10	anymore	anymore	ADV
cbi-27	76	11	because	because	SCONJ
cbi-27	76	12	of	of	ADP
cbi-27	76	13	the	the	DET
cbi-27	76	14	dependencies	dependency	NOUN
cbi-27	76	15	of	of	ADP
cbi-27	76	16	new	new	ADJ
cbi-27	76	17	functionality	functionality	NOUN
cbi-27	76	18	upon	upon	SCONJ
cbi-27	76	19	these	these	DET
cbi-27	76	20	older	old	ADJ
cbi-27	76	21	parts	part	NOUN
cbi-27	76	22	of	of	ADP
cbi-27	76	23	the	the	DET
cbi-27	76	24	systems	system	NOUN
cbi-27	76	25	.	.	PUNCT
cbi-27	77	1	many	many	ADJ
cbi-27	77	2	software	software	NOUN
cbi-27	77	3	systems	system	NOUN
cbi-27	77	4	contain	contain	VERB
cbi-27	77	5	old	old	ADJ
cbi-27	77	6	subsystems	subsystem	NOUN
cbi-27	77	7	that	that	PRON
cbi-27	77	8	were	be	AUX
cbi-27	77	9	developed	develop	VERB
cbi-27	77	10	some	some	DET
cbi-27	77	11	long	long	ADV
cbi-27	77	12	ago	ago	ADV
cbi-27	77	13	but	but	CCONJ
cbi-27	77	14	could	could	AUX
cbi-27	77	15	never	never	ADV
cbi-27	77	16	be	be	AUX
cbi-27	77	17	changed	change	VERB
cbi-27	77	18	because	because	SCONJ
cbi-27	77	19	the	the	DET
cbi-27	77	20	code	code	NOUN
cbi-27	77	21	is	be	AUX
cbi-27	77	22	essential	essential	ADJ
cbi-27	77	23	and	and	CCONJ
cbi-27	77	24	changing	change	VERB
cbi-27	77	25	it	it	PRON
cbi-27	77	26	could	could	AUX
cbi-27	77	27	cause	cause	VERB
cbi-27	77	28	them	they	PRON
cbi-27	77	29	not	not	PART
cbi-27	77	30	too	too	ADV
cbi-27	77	31	work	work	VERB
cbi-27	77	32	anymore	anymore	ADV
cbi-27	77	33	because	because	SCONJ
cbi-27	77	34	of	of	ADP
cbi-27	77	35	the	the	DET
cbi-27	77	36	many	many	ADJ
cbi-27	77	37	dependencies	dependency	NOUN
cbi-27	77	38	.	.	PUNCT
cbi-27	78	1	in	in	ADP
cbi-27	78	2	other	other	ADJ
cbi-27	78	3	words	word	NOUN
cbi-27	78	4	,	,	PUNCT
cbi-27	78	5	the	the	DET
cbi-27	78	6	functional	functional	ADJ
cbi-27	78	7	continuity	continuity	NOUN
cbi-27	78	8	of	of	ADP
cbi-27	78	9	the	the	DET
cbi-27	78	10	entire	entire	ADJ
cbi-27	78	11	system	system	NOUN
cbi-27	78	12	could	could	AUX
cbi-27	78	13	not	not	PART
cbi-27	78	14	be	be	AUX
cbi-27	78	15	guaranteed	guarantee	VERB
cbi-27	78	16	by	by	ADP
cbi-27	78	17	redesigning	redesign	VERB
cbi-27	78	18	the	the	DET
cbi-27	78	19	core	core	ADJ
cbi-27	78	20	part	part	NOUN
cbi-27	78	21	.	.	PUNCT
cbi-27	79	1	an	an	DET
cbi-27	79	2	example	example	NOUN
cbi-27	79	3	is	be	AUX
cbi-27	79	4	the	the	DET
cbi-27	79	5	old	old	ADJ
cbi-27	79	6	cobol	cobol	NOUN
cbi-27	79	7	code	code	NOUN
cbi-27	79	8	for	for	ADP
cbi-27	79	9	banking	banking	NOUN
cbi-27	79	10	systems	system	NOUN
cbi-27	79	11	that	that	PRON
cbi-27	79	12	were	be	AUX
cbi-27	79	13	developed	develop	VERB
cbi-27	79	14	in	in	ADP
cbi-27	79	15	the	the	DET
cbi-27	79	16	70s	70	NOUN
cbi-27	79	17	but	but	CCONJ
cbi-27	79	18	are	be	AUX
cbi-27	79	19	still	still	ADV
cbi-27	79	20	in	in	ADP
cbi-27	79	21	use	use	NOUN
cbi-27	79	22	until	until	SCONJ
cbi-27	79	23	a	a	DET
cbi-27	79	24	complete	complete	ADJ
cbi-27	79	25	redesign	redesign	NOUN
cbi-27	79	26	is	be	AUX
cbi-27	79	27	warranted	warrant	VERB
cbi-27	79	28	.	.	PUNCT
cbi-27	80	1	in	in	ADP
cbi-27	80	2	evolution	evolution	NOUN
cbi-27	80	3	,	,	PUNCT
cbi-27	80	4	there	there	PRON
cbi-27	80	5	is	be	VERB
cbi-27	80	6	no	no	DET
cbi-27	80	7	redesign	redesign	NOUN
cbi-27	80	8	possible	possible	ADJ
cbi-27	80	9	as	as	SCONJ
cbi-27	80	10	it	it	PRON
cbi-27	80	11	would	would	AUX
cbi-27	80	12	breach	breach	VERB
cbi-27	80	13	the	the	DET
cbi-27	80	14	functional	functional	ADJ
cbi-27	80	15	continuity	continuity	NOUN
cbi-27	80	16	that	that	PRON
cbi-27	80	17	is	be	AUX
cbi-27	80	18	needed	need	VERB
cbi-27	80	19	.	.	PUNCT
cbi-27	81	1	the	the	DET
cbi-27	81	2	risk	risk	NOUN
cbi-27	81	3	of	of	ADP
cbi-27	81	4	changing	change	VERB
cbi-27	81	5	them	they	PRON
cbi-27	81	6	for	for	ADP
cbi-27	81	7	the	the	DET
cbi-27	81	8	stability	stability	NOUN
cbi-27	81	9	of	of	ADP
cbi-27	81	10	the	the	DET
cbi-27	81	11	systems	system	NOUN
cbi-27	81	12	prevents	prevent	VERB
cbi-27	81	13	changing	change	VERB
cbi-27	81	14	them	they	PRON
cbi-27	81	15	.	.	PUNCT
cbi-27	82	1	3	3	NUM
cbi-27	82	2	the	the	DET
cbi-27	82	3	origin	origin	NOUN
cbi-27	82	4	of	of	ADP
cbi-27	82	5	life	life	NOUN
cbi-27	82	6	3.1	3.1	NUM
cbi-27	82	7	the	the	DET
cbi-27	82	8	central	central	ADJ
cbi-27	82	9	dogma	dogma	NOUN
cbi-27	82	10	of	of	ADP
cbi-27	82	11	biology	biology	NOUN
cbi-27	82	12	in	in	ADP
cbi-27	82	13	analogy	analogy	NOUN
cbi-27	82	14	with	with	ADP
cbi-27	82	15	software	software	NOUN
cbi-27	82	16	development	development	NOUN
cbi-27	82	17	,	,	PUNCT
cbi-27	82	18	if	if	SCONJ
cbi-27	82	19	we	we	PRON
cbi-27	82	20	want	want	VERB
cbi-27	82	21	to	to	PART
cbi-27	82	22	unravel	unravel	VERB
cbi-27	82	23	the	the	DET
cbi-27	82	24	origin	origin	NOUN
cbi-27	82	25	of	of	ADP
cbi-27	82	26	life	life	NOUN
cbi-27	82	27	we	we	PRON
cbi-27	82	28	should	should	AUX
cbi-27	82	29	first	first	ADV
cbi-27	82	30	define	define	VERB
cbi-27	82	31	the	the	DET
cbi-27	82	32	functional	functional	ADJ
cbi-27	82	33	modules	module	NOUN
cbi-27	82	34	and	and	CCONJ
cbi-27	82	35	their	their	PRON
cbi-27	82	36	interfaces	interface	NOUN
cbi-27	82	37	,	,	PUNCT
cbi-27	82	38	in	in	ADP
cbi-27	82	39	this	this	DET
cbi-27	82	40	case	case	NOUN
cbi-27	82	41	the	the	DET
cbi-27	82	42	molecular	molecular	ADJ
cbi-27	82	43	counterparts	counterpart	NOUN
cbi-27	82	44	of	of	ADP
cbi-27	82	45	modules	module	NOUN
cbi-27	82	46	and	and	CCONJ
cbi-27	82	47	interfaces	interface	NOUN
cbi-27	82	48	.	.	PUNCT
cbi-27	83	1	as	as	ADP
cbi-27	83	2	the	the	DET
cbi-27	83	3	basic	basic	ADJ
cbi-27	83	4	structural	structural	ADJ
cbi-27	83	5	entities	entity	NOUN
cbi-27	83	6	underlying	underlie	VERB
cbi-27	83	7	life	life	NOUN
cbi-27	83	8	,	,	PUNCT
cbi-27	83	9	we	we	PRON
cbi-27	83	10	can	can	AUX
cbi-27	83	11	discern	discern	VERB
cbi-27	83	12	the	the	DET
cbi-27	83	13	double	double	ADV
cbi-27	83	14	-	-	PUNCT
cbi-27	83	15	stranded	strand	VERB
cbi-27	83	16	dna	dna	NOUN
cbi-27	83	17	as	as	ADP
cbi-27	83	18	the	the	DET
cbi-27	83	19	carrier	carrier	NOUN
cbi-27	83	20	of	of	ADP
cbi-27	83	21	the	the	DET
cbi-27	83	22	genetic	genetic	ADJ
cbi-27	83	23	information	information	NOUN
cbi-27	83	24	,	,	PUNCT
cbi-27	83	25	the	the	DET
cbi-27	83	26	singlestranded	singlestranded	ADJ
cbi-27	83	27	rna	rna	NOUN
cbi-27	83	28	that	that	PRON
cbi-27	83	29	can	can	AUX
cbi-27	83	30	both	both	PRON
cbi-27	83	31	function	function	VERB
cbi-27	83	32	as	as	ADP
cbi-27	83	33	a	a	DET
cbi-27	83	34	ribozyme	ribozyme	NOUN
cbi-27	83	35	and	and	CCONJ
cbi-27	83	36	as	as	ADP
cbi-27	83	37	a	a	DET
cbi-27	83	38	template	template	NOUN
cbi-27	83	39	for	for	ADP
cbi-27	83	40	translation	translation	NOUN
cbi-27	83	41	into	into	ADP
cbi-27	83	42	proteins	protein	NOUN
cbi-27	83	43	.	.	PUNCT
cbi-27	84	1	the	the	DET
cbi-27	84	2	molecular	molecular	ADJ
cbi-27	84	3	machinery	machinery	NOUN
cbi-27	84	4	for	for	ADP
cbi-27	84	5	dna	dna	NOUN
cbi-27	84	6	replication	replication	NOUN
cbi-27	84	7	,	,	PUNCT
cbi-27	84	8	for	for	ADP
cbi-27	84	9	transcription	transcription	NOUN
cbi-27	84	10	and	and	CCONJ
cbi-27	84	11	for	for	ADP
cbi-27	84	12	translation	translation	NOUN
cbi-27	84	13	can	can	AUX
cbi-27	84	14	be	be	AUX
cbi-27	84	15	considered	consider	VERB
cbi-27	84	16	the	the	DET
cbi-27	84	17	functional	functional	ADJ
cbi-27	84	18	modules	module	NOUN
cbi-27	84	19	.	.	PUNCT
cbi-27	85	1	the	the	DET
cbi-27	85	2	interfaces	interface	NOUN
cbi-27	85	3	between	between	ADP
cbi-27	85	4	these	these	DET
cbi-27	85	5	three	three	NUM
cbi-27	85	6	functional	functional	ADJ
cbi-27	85	7	modules	module	NOUN
cbi-27	85	8	are	be	AUX
cbi-27	85	9	the	the	DET
cbi-27	85	10	double	double	ADV
cbi-27	85	11	-	-	PUNCT
cbi-27	85	12	stranded	strand	VERB
cbi-27	85	13	dna	dna	NOUN
cbi-27	85	14	helix	helix	NOUN
cbi-27	85	15	with	with	ADP
cbi-27	85	16	the	the	DET
cbi-27	85	17	four	four	NUM
cbi-27	85	18	bases	basis	NOUN
cbi-27	85	19	(	(	PUNCT
cbi-27	85	20	atcg	atcg	NOUN
cbi-27	85	21	)	)	PUNCT
cbi-27	85	22	,	,	PUNCT
cbi-27	85	23	and	and	CCONJ
cbi-27	85	24	the	the	DET
cbi-27	85	25	single	single	ADJ
cbi-27	85	26	-	-	PUNCT
cbi-27	85	27	stranded	strand	VERB
cbi-27	85	28	rna	rna	NOUN
cbi-27	85	29	with	with	ADP
cbi-27	85	30	the	the	DET
cbi-27	85	31	four	four	NUM
cbi-27	85	32	rna	rna	NOUN
cbi-27	85	33	bases	basis	NOUN
cbi-27	85	34	(	(	PUNCT
cbi-27	85	35	aucg	aucg	NOUN
cbi-27	85	36	)	)	PUNCT
cbi-27	85	37	as	as	ADP
cbi-27	85	38	template	template	NOUN
cbi-27	85	39	for	for	ADP
cbi-27	85	40	translation	translation	NOUN
cbi-27	85	41	into	into	ADP
cbi-27	85	42	proteins	protein	NOUN
cbi-27	85	43	.	.	PUNCT
cbi-27	86	1	this	this	DET
cbi-27	86	2	configuration	configuration	NOUN
cbi-27	86	3	is	be	AUX
cbi-27	86	4	called	call	VERB
cbi-27	86	5	’	'	PUNCT
cbi-27	86	6	the	the	DET
cbi-27	86	7	central	central	ADJ
cbi-27	86	8	dogma	dogma	NOUN
cbi-27	86	9	of	of	ADP
cbi-27	86	10	biology	biology	NOUN
cbi-27	86	11	’	'	PUNCT
cbi-27	86	12	.	.	PUNCT
cbi-27	87	1	3.2	3.2	NUM
cbi-27	87	2	evolution	evolution	NOUN
cbi-27	87	3	of	of	ADP
cbi-27	87	4	the	the	DET
cbi-27	87	5	dogma	dogma	NOUN
cbi-27	87	6	of	of	ADP
cbi-27	87	7	biology	biology	NOUN
cbi-27	87	8	if	if	SCONJ
cbi-27	87	9	we	we	PRON
cbi-27	87	10	look	look	VERB
cbi-27	87	11	at	at	ADP
cbi-27	87	12	the	the	DET
cbi-27	87	13	dependency	dependency	NOUN
cbi-27	87	14	and	and	CCONJ
cbi-27	87	15	the	the	DET
cbi-27	87	16	relations	relation	NOUN
cbi-27	87	17	between	between	ADP
cbi-27	87	18	the	the	DET
cbi-27	87	19	functional	functional	ADJ
cbi-27	87	20	modules	module	NOUN
cbi-27	87	21	of	of	ADP
cbi-27	87	22	the	the	DET
cbi-27	87	23	central	central	ADJ
cbi-27	87	24	dogma	dogma	NOUN
cbi-27	87	25	,	,	PUNCT
cbi-27	87	26	we	we	PRON
cbi-27	87	27	can	can	AUX
cbi-27	87	28	deduce	deduce	VERB
cbi-27	87	29	the	the	DET
cbi-27	87	30	sequence	sequence	NOUN
cbi-27	87	31	of	of	ADP
cbi-27	87	32	evolutionary	evolutionary	ADJ
cbi-27	87	33	events	event	NOUN
cbi-27	87	34	.	.	PUNCT
cbi-27	88	1	dna	dna	PROPN
cbi-27	88	2	is	be	AUX
cbi-27	88	3	transcribed	transcribe	VERB
cbi-27	88	4	into	into	ADP
cbi-27	88	5	8	8	NUM
cbi-27	88	6	a	a	DET
cbi-27	88	7	proposed	propose	VERB
cbi-27	88	8	framework	framework	NOUN
cbi-27	88	9	for	for	ADP
cbi-27	88	10	cellular	cellular	ADJ
cbi-27	88	11	evolution	evolution	NOUN
cbi-27	88	12	rna	rna	NOUN
cbi-27	88	13	that	that	PRON
cbi-27	88	14	functions	function	NOUN
cbi-27	88	15	as	as	ADP
cbi-27	88	16	the	the	DET
cbi-27	88	17	code	code	NOUN
cbi-27	88	18	(	(	PUNCT
cbi-27	88	19	interface	interface	NOUN
cbi-27	88	20	)	)	PUNCT
cbi-27	88	21	for	for	ADP
cbi-27	88	22	the	the	DET
cbi-27	88	23	proteins	protein	NOUN
cbi-27	88	24	translation	translation	NOUN
cbi-27	88	25	,	,	PUNCT
cbi-27	88	26	so	so	ADV
cbi-27	88	27	double	double	ADJ
cbi-27	88	28	-	-	PUNCT
cbi-27	88	29	stranded	strand	VERB
cbi-27	88	30	dna	dna	NOUN
cbi-27	88	31	had	have	VERB
cbi-27	88	32	to	to	PART
cbi-27	88	33	be	be	AUX
cbi-27	88	34	first	first	ADJ
cbi-27	88	35	to	to	PART
cbi-27	88	36	have	have	AUX
cbi-27	88	37	evolved	evolve	VERB
cbi-27	88	38	.	.	PUNCT
cbi-27	89	1	from	from	ADP
cbi-27	89	2	this	this	DET
cbi-27	89	3	initial	initial	ADJ
cbi-27	89	4	dna	dna	NOUN
cbi-27	89	5	,	,	PUNCT
cbi-27	89	6	single	single	ADJ
cbi-27	89	7	-	-	PUNCT
cbi-27	89	8	stranded	strand	VERB
cbi-27	89	9	rna	rna	NOUN
cbi-27	89	10	was	be	AUX
cbi-27	89	11	derived	derive	VERB
cbi-27	89	12	which	which	PRON
cbi-27	89	13	first	first	ADV
cbi-27	89	14	functioned	function	VERB
cbi-27	89	15	as	as	ADP
cbi-27	89	16	catalytic	catalytic	ADJ
cbi-27	89	17	rna	rna	NOUN
cbi-27	89	18	.	.	PUNCT
cbi-27	90	1	using	use	VERB
cbi-27	90	2	the	the	DET
cbi-27	90	3	catalytic	catalytic	ADJ
cbi-27	90	4	characteristics	characteristic	NOUN
cbi-27	90	5	of	of	ADP
cbi-27	90	6	single	single	ADJ
cbi-27	90	7	-	-	PUNCT
cbi-27	90	8	stranded	strand	VERB
cbi-27	90	9	rna	rna	NOUN
cbi-27	90	10	the	the	DET
cbi-27	90	11	first	first	ADJ
cbi-27	90	12	proteins	protein	NOUN
cbi-27	90	13	were	be	AUX
cbi-27	90	14	made	make	VERB
cbi-27	90	15	using	use	VERB
cbi-27	90	16	single	single	ADJ
cbi-27	90	17	-	-	PUNCT
cbi-27	90	18	stranded	strand	VERB
cbi-27	90	19	rna	rna	NOUN
cbi-27	90	20	(	(	PUNCT
cbi-27	90	21	mrna	mrna	PROPN
cbi-27	90	22	)	)	PUNCT
cbi-27	90	23	.	.	PUNCT
cbi-27	91	1	thus	thus	ADV
cbi-27	91	2	,	,	PUNCT
cbi-27	91	3	we	we	PRON
cbi-27	91	4	can	can	AUX
cbi-27	91	5	directly	directly	ADV
cbi-27	91	6	reverse	reverse	VERB
cbi-27	91	7	engineer	engineer	VERB
cbi-27	91	8	the	the	DET
cbi-27	91	9	steps	step	NOUN
cbi-27	91	10	in	in	ADP
cbi-27	91	11	evolution	evolution	NOUN
cbi-27	91	12	from	from	ADP
cbi-27	91	13	the	the	DET
cbi-27	91	14	developmental	developmental	ADJ
cbi-27	91	15	steps	step	NOUN
cbi-27	91	16	,	,	PUNCT
cbi-27	91	17	just	just	ADV
cbi-27	91	18	by	by	ADP
cbi-27	91	19	studying	study	VERB
cbi-27	91	20	the	the	DET
cbi-27	91	21	interfaces	interface	NOUN
cbi-27	91	22	and	and	CCONJ
cbi-27	91	23	their	their	PRON
cbi-27	91	24	dependencies	dependency	NOUN
cbi-27	91	25	.	.	PUNCT
cbi-27	92	1	the	the	DET
cbi-27	92	2	general	general	ADJ
cbi-27	92	3	rule	rule	NOUN
cbi-27	92	4	here	here	ADV
cbi-27	92	5	is	be	AUX
cbi-27	92	6	that	that	SCONJ
cbi-27	92	7	we	we	PRON
cbi-27	92	8	look	look	VERB
cbi-27	92	9	at	at	ADP
cbi-27	92	10	the	the	DET
cbi-27	92	11	flow	flow	NOUN
cbi-27	92	12	in	in	ADP
cbi-27	92	13	development	development	NOUN
cbi-27	92	14	steps	step	NOUN
cbi-27	92	15	(	(	PUNCT
cbi-27	92	16	dsdna	dsdna	ADV
cbi-27	92	17	to	to	PART
cbi-27	92	18	ssrna	ssrna	VERB
cbi-27	92	19	to	to	ADP
cbi-27	92	20	protein	protein	NOUN
cbi-27	92	21	)	)	PUNCT
cbi-27	92	22	to	to	PART
cbi-27	92	23	deduce	deduce	VERB
cbi-27	92	24	the	the	DET
cbi-27	92	25	evolutionary	evolutionary	ADJ
cbi-27	92	26	steps	step	NOUN
cbi-27	92	27	.	.	PUNCT
cbi-27	93	1	3.3	3.3	NUM
cbi-27	93	2	double	double	ADV
cbi-27	93	3	-	-	PUNCT
cbi-27	93	4	stranded	strand	VERB
cbi-27	93	5	dna	dna	NOUN
cbi-27	93	6	all	all	DET
cbi-27	93	7	life	life	NOUN
cbi-27	93	8	is	be	AUX
cbi-27	93	9	based	base	VERB
cbi-27	93	10	on	on	ADP
cbi-27	93	11	double	double	ADJ
cbi-27	93	12	-	-	PUNCT
cbi-27	93	13	stranded	strand	VERB
cbi-27	93	14	dna	dna	NOUN
cbi-27	93	15	and	and	CCONJ
cbi-27	93	16	it	it	PRON
cbi-27	93	17	is	be	AUX
cbi-27	93	18	therefore	therefore	ADV
cbi-27	93	19	important	important	ADJ
cbi-27	93	20	to	to	PART
cbi-27	93	21	see	see	VERB
cbi-27	93	22	how	how	SCONJ
cbi-27	93	23	this	this	DET
cbi-27	93	24	double	double	ADJ
cbi-27	93	25	-	-	PUNCT
cbi-27	93	26	stranded	strand	VERB
cbi-27	93	27	dna	dna	NOUN
cbi-27	93	28	could	could	AUX
cbi-27	93	29	have	have	AUX
cbi-27	93	30	evolved	evolve	VERB
cbi-27	93	31	in	in	ADP
cbi-27	93	32	the	the	DET
cbi-27	93	33	first	first	ADJ
cbi-27	93	34	place	place	NOUN
cbi-27	93	35	.	.	PUNCT
cbi-27	94	1	dna	dna	PROPN
cbi-27	94	2	is	be	AUX
cbi-27	94	3	composed	compose	VERB
cbi-27	94	4	of	of	ADP
cbi-27	94	5	nucleotides	nucleotide	NOUN
cbi-27	94	6	that	that	PRON
cbi-27	94	7	have	have	VERB
cbi-27	94	8	the	the	DET
cbi-27	94	9	tendency	tendency	NOUN
cbi-27	94	10	to	to	PART
cbi-27	94	11	stick	stick	VERB
cbi-27	94	12	to	to	ADP
cbi-27	94	13	other	other	ADJ
cbi-27	94	14	types	type	NOUN
cbi-27	94	15	of	of	ADP
cbi-27	94	16	nucleotides	nucleotide	NOUN
cbi-27	94	17	.	.	PUNCT
cbi-27	95	1	nucleotides	nucleotide	NOUN
cbi-27	95	2	can	can	AUX
cbi-27	95	3	also	also	ADV
cbi-27	95	4	form	form	VERB
cbi-27	95	5	covalent	covalent	ADJ
cbi-27	95	6	bonds	bond	NOUN
cbi-27	95	7	between	between	ADP
cbi-27	95	8	them	they	PRON
cbi-27	95	9	,	,	PUNCT
cbi-27	95	10	so	so	SCONJ
cbi-27	95	11	that	that	SCONJ
cbi-27	95	12	they	they	PRON
cbi-27	95	13	can	can	AUX
cbi-27	95	14	form	form	VERB
cbi-27	95	15	strands	strand	NOUN
cbi-27	95	16	.	.	PUNCT
cbi-27	96	1	the	the	DET
cbi-27	96	2	combination	combination	NOUN
cbi-27	96	3	between	between	ADP
cbi-27	96	4	single	single	ADJ
cbi-27	96	5	-	-	PUNCT
cbi-27	96	6	strand	strand	NOUN
cbi-27	96	7	formation	formation	NOUN
cbi-27	96	8	and	and	CCONJ
cbi-27	96	9	hydrogen	hydrogen	NOUN
cbi-27	96	10	-	-	PUNCT
cbi-27	96	11	bonding	bonding	NOUN
cbi-27	96	12	between	between	ADP
cbi-27	96	13	the	the	DET
cbi-27	96	14	nucleotides	nucleotide	NOUN
cbi-27	96	15	can	can	AUX
cbi-27	96	16	make	make	VERB
cbi-27	96	17	that	that	SCONJ
cbi-27	96	18	the	the	DET
cbi-27	96	19	strands	strand	NOUN
cbi-27	96	20	bind	bind	VERB
cbi-27	96	21	to	to	ADP
cbi-27	96	22	complementary	complementary	ADJ
cbi-27	96	23	strands	strand	NOUN
cbi-27	96	24	of	of	ADP
cbi-27	96	25	dna	dna	NOUN
cbi-27	96	26	forming	form	VERB
cbi-27	96	27	a	a	DET
cbi-27	96	28	double	double	ADJ
cbi-27	96	29	-	-	PUNCT
cbi-27	96	30	stranded	strand	VERB
cbi-27	96	31	dna	dna	NOUN
cbi-27	96	32	.	.	PUNCT
cbi-27	97	1	thus	thus	ADV
cbi-27	97	2	,	,	PUNCT
cbi-27	97	3	the	the	DET
cbi-27	97	4	double	double	ADV
cbi-27	97	5	-	-	PUNCT
cbi-27	97	6	stranded	strand	VERB
cbi-27	97	7	dna	dna	NOUN
cbi-27	97	8	can	can	AUX
cbi-27	97	9	be	be	AUX
cbi-27	97	10	formed	form	VERB
cbi-27	97	11	based	base	VERB
cbi-27	97	12	on	on	ADP
cbi-27	97	13	the	the	DET
cbi-27	97	14	basic	basic	ADJ
cbi-27	97	15	characteristic	characteristic	NOUN
cbi-27	97	16	of	of	ADP
cbi-27	97	17	nucleotides	nucleotide	NOUN
cbi-27	97	18	to	to	PART
cbi-27	97	19	form	form	VERB
cbi-27	97	20	covalent	covalent	ADJ
cbi-27	97	21	bonds	bond	NOUN
cbi-27	97	22	between	between	ADP
cbi-27	97	23	nucleotides	nucleotide	NOUN
cbi-27	97	24	and	and	CCONJ
cbi-27	97	25	hydrogen	hydrogen	NOUN
cbi-27	97	26	bonds	bond	NOUN
cbi-27	97	27	between	between	ADP
cbi-27	97	28	complementary	complementary	ADJ
cbi-27	97	29	nucleotides	nucleotide	NOUN
cbi-27	97	30	.	.	PUNCT
cbi-27	98	1	nucleotides	nucleotide	NOUN
cbi-27	98	2	and	and	CCONJ
cbi-27	98	3	their	their	PRON
cbi-27	98	4	capability	capability	NOUN
cbi-27	98	5	to	to	PART
cbi-27	98	6	form	form	VERB
cbi-27	98	7	covalent	covalent	ADJ
cbi-27	98	8	bonds	bond	NOUN
cbi-27	98	9	and	and	CCONJ
cbi-27	98	10	their	their	PRON
cbi-27	98	11	intrinsic	intrinsic	ADJ
cbi-27	98	12	tendency	tendency	NOUN
cbi-27	98	13	to	to	PART
cbi-27	98	14	form	form	VERB
cbi-27	98	15	complementary	complementary	ADJ
cbi-27	98	16	strands	strand	NOUN
cbi-27	98	17	can	can	AUX
cbi-27	98	18	form	form	VERB
cbi-27	98	19	the	the	DET
cbi-27	98	20	first	first	ADJ
cbi-27	98	21	interface	interface	NOUN
cbi-27	98	22	for	for	ADP
cbi-27	98	23	life	life	NOUN
cbi-27	98	24	.	.	PUNCT
cbi-27	99	1	although	although	SCONJ
cbi-27	99	2	it	it	PRON
cbi-27	99	3	is	be	AUX
cbi-27	99	4	thought	think	VERB
cbi-27	99	5	that	that	SCONJ
cbi-27	99	6	rna	rna	NOUN
cbi-27	99	7	would	would	AUX
cbi-27	99	8	precede	precede	VERB
cbi-27	99	9	dna	dna	NOUN
cbi-27	99	10	as	as	ADP
cbi-27	99	11	a	a	DET
cbi-27	99	12	prebiotic	prebiotic	ADJ
cbi-27	99	13	molecule	molecule	NOUN
cbi-27	99	14	,	,	PUNCT
cbi-27	99	15	they	they	PRON
cbi-27	99	16	have	have	VERB
cbi-27	99	17	similar	similar	ADJ
cbi-27	99	18	characteristics	characteristic	NOUN
cbi-27	99	19	and	and	CCONJ
cbi-27	99	20	a	a	DET
cbi-27	99	21	later	later	ADJ
cbi-27	99	22	change	change	NOUN
cbi-27	99	23	to	to	ADP
cbi-27	99	24	dna	dna	PROPN
cbi-27	99	25	would	would	AUX
cbi-27	99	26	not	not	PART
cbi-27	99	27	affect	affect	VERB
cbi-27	99	28	any	any	DET
cbi-27	99	29	interfaces	interface	NOUN
cbi-27	99	30	based	base	VERB
cbi-27	99	31	on	on	ADP
cbi-27	99	32	rna	rna	PROPN
cbi-27	99	33	.	.	PUNCT
cbi-27	100	1	3.4	3.4	NUM
cbi-27	100	2	replication	replication	NOUN
cbi-27	100	3	of	of	ADP
cbi-27	100	4	dna	dna	PROPN
cbi-27	100	5	replication	replication	NOUN
cbi-27	100	6	of	of	ADP
cbi-27	100	7	dna	dna	PROPN
cbi-27	100	8	is	be	AUX
cbi-27	100	9	based	base	VERB
cbi-27	100	10	on	on	ADP
cbi-27	100	11	the	the	DET
cbi-27	100	12	characteristic	characteristic	NOUN
cbi-27	100	13	of	of	ADP
cbi-27	100	14	dna	dna	NOUN
cbi-27	100	15	that	that	PRON
cbi-27	100	16	it	it	PRON
cbi-27	100	17	can	can	AUX
cbi-27	100	18	form	form	VERB
cbi-27	100	19	its	its	PRON
cbi-27	100	20	own	own	ADJ
cbi-27	100	21	template	template	NOUN
cbi-27	100	22	,	,	PUNCT
cbi-27	100	23	but	but	CCONJ
cbi-27	100	24	in	in	ADP
cbi-27	100	25	order	order	NOUN
cbi-27	100	26	to	to	PART
cbi-27	100	27	replicate	replicate	VERB
cbi-27	100	28	the	the	DET
cbi-27	100	29	strands	strand	NOUN
cbi-27	100	30	have	have	VERB
cbi-27	100	31	to	to	PART
cbi-27	100	32	be	be	AUX
cbi-27	100	33	separated	separate	VERB
cbi-27	100	34	.	.	PUNCT
cbi-27	101	1	the	the	DET
cbi-27	101	2	covalent	covalent	ADJ
cbi-27	101	3	bonds	bond	NOUN
cbi-27	101	4	between	between	ADP
cbi-27	101	5	the	the	DET
cbi-27	101	6	nucleotides	nucleotide	NOUN
cbi-27	101	7	that	that	PRON
cbi-27	101	8	form	form	VERB
cbi-27	101	9	the	the	DET
cbi-27	101	10	single	single	ADV
cbi-27	101	11	-	-	PUNCT
cbi-27	101	12	stranded	strand	VERB
cbi-27	101	13	dna	dna	NOUN
cbi-27	101	14	are	be	AUX
cbi-27	101	15	quite	quite	ADV
cbi-27	101	16	strong	strong	ADJ
cbi-27	101	17	,	,	PUNCT
cbi-27	101	18	but	but	CCONJ
cbi-27	101	19	the	the	DET
cbi-27	101	20	hydrogen	hydrogen	NOUN
cbi-27	101	21	bonds	bond	NOUN
cbi-27	101	22	between	between	ADP
cbi-27	101	23	different	different	ADJ
cbi-27	101	24	strands	strand	NOUN
cbi-27	101	25	can	can	AUX
cbi-27	101	26	be	be	AUX
cbi-27	101	27	broken	break	VERB
cbi-27	101	28	more	more	ADV
cbi-27	101	29	easily	easily	ADV
cbi-27	101	30	for	for	ADP
cbi-27	101	31	instance	instance	NOUN
cbi-27	101	32	by	by	ADP
cbi-27	101	33	heating	heat	VERB
cbi-27	101	34	the	the	DET
cbi-27	101	35	double	double	ADV
cbi-27	101	36	-	-	PUNCT
cbi-27	101	37	stranded	strand	VERB
cbi-27	101	38	dna	dna	NOUN
cbi-27	101	39	.	.	PUNCT
cbi-27	102	1	this	this	DET
cbi-27	102	2	process	process	NOUN
cbi-27	102	3	is	be	AUX
cbi-27	102	4	also	also	ADV
cbi-27	102	5	called	call	VERB
cbi-27	102	6	melting	melting	NOUN
cbi-27	102	7	of	of	ADP
cbi-27	102	8	dna	dna	NOUN
cbi-27	102	9	and	and	CCONJ
cbi-27	102	10	yields	yield	VERB
cbi-27	102	11	two	two	NUM
cbi-27	102	12	separate	separate	ADJ
cbi-27	102	13	strands	strand	NOUN
cbi-27	102	14	of	of	ADP
cbi-27	102	15	dna	dna	NOUN
cbi-27	102	16	.	.	PUNCT
cbi-27	103	1	the	the	DET
cbi-27	103	2	melting	melting	NOUN
cbi-27	103	3	of	of	ADP
cbi-27	103	4	dna	dna	PROPN
cbi-27	103	5	can	can	AUX
cbi-27	103	6	be	be	AUX
cbi-27	103	7	done	do	VERB
cbi-27	103	8	by	by	ADP
cbi-27	103	9	an	an	DET
cbi-27	103	10	increase	increase	NOUN
cbi-27	103	11	in	in	ADP
cbi-27	103	12	temperature	temperature	NOUN
cbi-27	103	13	,	,	PUNCT
cbi-27	103	14	but	but	CCONJ
cbi-27	103	15	also	also	ADV
cbi-27	103	16	through	through	ADP
cbi-27	103	17	the	the	DET
cbi-27	103	18	action	action	NOUN
cbi-27	103	19	of	of	ADP
cbi-27	103	20	proteins	protein	NOUN
cbi-27	103	21	.	.	PUNCT
cbi-27	104	1	as	as	SCONJ
cbi-27	104	2	proteins	protein	NOUN
cbi-27	104	3	were	be	AUX
cbi-27	104	4	not	not	PART
cbi-27	104	5	present	present	ADJ
cbi-27	104	6	at	at	ADP
cbi-27	104	7	the	the	DET
cbi-27	104	8	origin	origin	NOUN
cbi-27	104	9	of	of	ADP
cbi-27	104	10	life	life	NOUN
cbi-27	104	11	,	,	PUNCT
cbi-27	104	12	melting	melt	VERB
cbi-27	104	13	by	by	ADP
cbi-27	104	14	an	an	DET
cbi-27	104	15	increase	increase	NOUN
cbi-27	104	16	in	in	ADP
cbi-27	104	17	temperature	temperature	NOUN
cbi-27	104	18	is	be	AUX
cbi-27	104	19	likely	likely	ADJ
cbi-27	104	20	to	to	PART
cbi-27	104	21	be	be	AUX
cbi-27	104	22	the	the	DET
cbi-27	104	23	first	first	ADJ
cbi-27	104	24	way	way	NOUN
cbi-27	104	25	of	of	ADP
cbi-27	104	26	separating	separate	VERB
cbi-27	104	27	the	the	DET
cbi-27	104	28	two	two	NUM
cbi-27	104	29	strands	strand	NOUN
cbi-27	104	30	for	for	ADP
cbi-27	104	31	replication	replication	NOUN
cbi-27	104	32	.	.	PUNCT
cbi-27	105	1	the	the	DET
cbi-27	105	2	day	day	NOUN
cbi-27	105	3	/	/	SYM
cbi-27	105	4	night	night	NOUN
cbi-27	105	5	cycle	cycle	NOUN
cbi-27	105	6	may	may	AUX
cbi-27	105	7	have	have	AUX
cbi-27	105	8	provided	provide	VERB
cbi-27	105	9	the	the	DET
cbi-27	105	10	necessary	necessary	ADJ
cbi-27	105	11	heating	heating	NOUN
cbi-27	105	12	and	and	CCONJ
cbi-27	105	13	cooling	cooling	NOUN
cbi-27	105	14	of	of	ADP
cbi-27	105	15	an	an	DET
cbi-27	105	16	original	original	ADJ
cbi-27	105	17	dna	dna	NOUN
cbi-27	105	18	mixture	mixture	NOUN
cbi-27	105	19	for	for	ADP
cbi-27	105	20	early	early	ADJ
cbi-27	105	21	life	life	NOUN
cbi-27	105	22	,	,	PUNCT
cbi-27	105	23	similar	similar	ADJ
cbi-27	105	24	to	to	ADP
cbi-27	105	25	the	the	DET
cbi-27	105	26	pcr	pcr	ADJ
cbi-27	105	27	reaction	reaction	NOUN
cbi-27	105	28	in	in	ADP
cbi-27	105	29	which	which	PRON
cbi-27	105	30	dna	dna	PROPN
cbi-27	105	31	is	be	AUX
cbi-27	105	32	replicated	replicate	VERB
cbi-27	105	33	in	in	ADP
cbi-27	105	34	a	a	DET
cbi-27	105	35	laboratory	laboratory	NOUN
cbi-27	105	36	.	.	PUNCT
cbi-27	106	1	even	even	ADV
cbi-27	106	2	though	though	SCONJ
cbi-27	106	3	the	the	DET
cbi-27	106	4	replication	replication	NOUN
cbi-27	106	5	process	process	NOUN
cbi-27	106	6	is	be	AUX
cbi-27	106	7	now	now	ADV
cbi-27	106	8	facilitated	facilitate	VERB
cbi-27	106	9	by	by	ADP
cbi-27	106	10	proteins	protein	NOUN
cbi-27	106	11	,	,	PUNCT
cbi-27	106	12	its	its	PRON
cbi-27	106	13	basic	basic	ADJ
cbi-27	106	14	mechanism	mechanism	NOUN
cbi-27	106	15	has	have	AUX
cbi-27	106	16	not	not	PART
cbi-27	106	17	changed	change	VERB
cbi-27	106	18	.	.	PUNCT
cbi-27	107	1	3.5	3.5	NUM
cbi-27	107	2	transcription	transcription	NOUN
cbi-27	107	3	of	of	ADP
cbi-27	107	4	dna	dna	NOUN
cbi-27	107	5	into	into	ADP
cbi-27	107	6	rna	rna	PROPN
cbi-27	107	7	if	if	SCONJ
cbi-27	107	8	we	we	PRON
cbi-27	107	9	look	look	VERB
cbi-27	107	10	at	at	ADP
cbi-27	107	11	the	the	DET
cbi-27	107	12	current	current	ADJ
cbi-27	107	13	events	event	NOUN
cbi-27	107	14	in	in	ADP
cbi-27	107	15	the	the	DET
cbi-27	107	16	life	life	NOUN
cbi-27	107	17	cycle	cycle	NOUN
cbi-27	107	18	of	of	ADP
cbi-27	107	19	an	an	DET
cbi-27	107	20	organism	organism	NOUN
cbi-27	107	21	,	,	PUNCT
cbi-27	107	22	we	we	PRON
cbi-27	107	23	see	see	VERB
cbi-27	107	24	that	that	SCONJ
cbi-27	107	25	apart	apart	ADV
cbi-27	107	26	from	from	ADP
cbi-27	107	27	serving	serve	VERB
cbi-27	107	28	as	as	ADP
cbi-27	107	29	its	its	PRON
cbi-27	107	30	own	own	ADJ
cbi-27	107	31	template	template	NOUN
cbi-27	107	32	for	for	ADP
cbi-27	107	33	replication	replication	NOUN
cbi-27	107	34	,	,	PUNCT
cbi-27	107	35	single	single	ADJ
cbi-27	107	36	-	-	PUNCT
cbi-27	107	37	stranded	strand	VERB
cbi-27	107	38	rna	rna	NOUN
cbi-27	107	39	is	be	AUX
cbi-27	107	40	also	also	ADV
cbi-27	107	41	generated	generate	VERB
cbi-27	107	42	from	from	ADP
cbi-27	107	43	the	the	DET
cbi-27	107	44	same	same	ADJ
cbi-27	107	45	template	template	NOUN
cbi-27	107	46	.	.	PUNCT
cbi-27	108	1	mechanistically	mechanistically	ADV
cbi-27	108	2	in	in	ADP
cbi-27	108	3	an	an	DET
cbi-27	108	4	abiotic	abiotic	ADJ
cbi-27	108	5	cycle	cycle	NOUN
cbi-27	108	6	,	,	PUNCT
cbi-27	108	7	the	the	DET
cbi-27	108	8	formation	formation	NOUN
cbi-27	108	9	of	of	ADP
cbi-27	108	10	single	single	ADJ
cbi-27	108	11	stranded	strand	VERB
cbi-27	108	12	rna	rna	NOUN
cbi-27	108	13	can	can	AUX
cbi-27	108	14	be	be	AUX
cbi-27	108	15	relatively	relatively	ADV
cbi-27	108	16	easy	easy	ADJ
cbi-27	108	17	accomplished	accomplish	VERB
cbi-27	108	18	by	by	ADP
cbi-27	108	19	partially	partially	ADV
cbi-27	108	20	melting	melting	NOUN
cbi-27	108	21	of	of	ADP
cbi-27	108	22	the	the	DET
cbi-27	108	23	dna	dna	NOUN
cbi-27	108	24	and	and	CCONJ
cbi-27	108	25	the	the	DET
cbi-27	108	26	’	'	PUNCT
cbi-27	108	27	replication	replication	NOUN
cbi-27	108	28	’	'	PUNCT
cbi-27	108	29	of	of	ADP
cbi-27	108	30	the	the	DET
cbi-27	108	31	exposed	expose	VERB
cbi-27	108	32	single	single	ADJ
cbi-27	108	33	-	-	PUNCT
cbi-27	108	34	stranded	strand	VERB
cbi-27	108	35	dna	dna	NOUN
cbi-27	108	36	.	.	PUNCT
cbi-27	109	1	this	this	DET
cbi-27	109	2	process	process	NOUN
cbi-27	109	3	is	be	AUX
cbi-27	109	4	not	not	PART
cbi-27	109	5	fundamentally	fundamentally	ADV
cbi-27	109	6	different	different	ADJ
cbi-27	109	7	from	from	ADP
cbi-27	109	8	what	what	PRON
cbi-27	109	9	happens	happen	VERB
cbi-27	109	10	in	in	ADP
cbi-27	109	11	transcription	transcription	NOUN
cbi-27	109	12	where	where	SCONJ
cbi-27	109	13	the	the	DET
cbi-27	109	14	dna	dna	NOUN
cbi-27	109	15	is	be	AUX
cbi-27	109	16	partial	partial	ADJ
cbi-27	109	17	single	single	ADV
cbi-27	109	18	-	-	PUNCT
cbi-27	109	19	stranded	strand	VERB
cbi-27	109	20	(	(	PUNCT
cbi-27	109	21	in	in	ADP
cbi-27	109	22	the	the	DET
cbi-27	109	23	transcription	transcription	NOUN
cbi-27	109	24	bubble	bubble	NOUN
cbi-27	109	25	)	)	PUNCT
cbi-27	109	26	so	so	SCONJ
cbi-27	109	27	that	that	SCONJ
cbi-27	109	28	genes	gene	NOUN
cbi-27	109	29	can	can	AUX
cbi-27	109	30	be	be	AUX
cbi-27	109	31	transcribed	transcribe	VERB
cbi-27	109	32	.	.	PUNCT
cbi-27	110	1	single	single	ADJ
cbi-27	110	2	-	-	PUNCT
cbi-27	110	3	stranded	strand	VERB
cbi-27	110	4	rna	rna	NOUN
cbi-27	110	5	is	be	AUX
cbi-27	110	6	directly	directly	ADV
cbi-27	110	7	transcribed	transcribe	VERB
cbi-27	110	8	from	from	ADP
cbi-27	110	9	the	the	DET
cbi-27	110	10	double	double	ADJ
cbi-27	110	11	-	-	PUNCT
cbi-27	110	12	stranded	strand	VERB
cbi-27	110	13	dna	dna	NOUN
cbi-27	110	14	and	and	CCONJ
cbi-27	110	15	can	can	AUX
cbi-27	110	16	function	function	VERB
cbi-27	110	17	by	by	ADP
cbi-27	110	18	itself	itself	PRON
cbi-27	110	19	as	as	ADP
cbi-27	110	20	a	a	DET
cbi-27	110	21	catalyst	catalyst	NOUN
cbi-27	110	22	(	(	PUNCT
cbi-27	110	23	hence	hence	ADV
cbi-27	110	24	the	the	DET
cbi-27	110	25	term	term	NOUN
cbi-27	110	26	catalytic	catalytic	ADJ
cbi-27	110	27	rna	rna	NOUN
cbi-27	110	28	)	)	PUNCT
cbi-27	110	29	or	or	CCONJ
cbi-27	110	30	as	as	ADP
cbi-27	110	31	a	a	DET
cbi-27	110	32	template	template	NOUN
cbi-27	110	33	for	for	ADP
cbi-27	110	34	proteins	protein	NOUN
cbi-27	110	35	in	in	ADP
cbi-27	110	36	a	a	DET
cbi-27	110	37	separate	separate	ADJ
cbi-27	110	38	process	process	NOUN
cbi-27	110	39	.	.	PUNCT
cbi-27	111	1	throughout	throughout	ADP
cbi-27	111	2	evolution	evolution	NOUN
cbi-27	111	3	,	,	PUNCT
cbi-27	111	4	the	the	DET
cbi-27	111	5	transcription	transcription	NOUN
cbi-27	111	6	process	process	NOUN
cbi-27	111	7	has	have	AUX
cbi-27	111	8	not	not	PART
cbi-27	111	9	been	be	AUX
cbi-27	111	10	changed	change	VERB
cbi-27	111	11	fundamentally	fundamentally	ADV
cbi-27	111	12	and	and	CCONJ
cbi-27	111	13	the	the	DET
cbi-27	111	14	interface	interface	NOUN
cbi-27	111	15	(	(	PUNCT
cbi-27	111	16	double	double	ADJ
cbi-27	111	17	-	-	PUNCT
cbi-27	111	18	stranded	strand	VERB
cbi-27	111	19	dna	dna	NOUN
cbi-27	111	20	that	that	PRON
cbi-27	111	21	codes	code	VERB
cbi-27	111	22	for	for	ADP
cbi-27	111	23	single	single	ADJ
cbi-27	111	24	-	-	PUNCT
cbi-27	111	25	stranded	strand	VERB
cbi-27	111	26	rna	rna	NOUN
cbi-27	111	27	has	have	AUX
cbi-27	111	28	not	not	PART
cbi-27	111	29	changed	change	VERB
cbi-27	111	30	.	.	PUNCT
cbi-27	112	1	3.6	3.6	NUM
cbi-27	112	2	protein	protein	NOUN
cbi-27	112	3	translation	translation	NOUN
cbi-27	112	4	from	from	ADP
cbi-27	112	5	mrna	mrna	PROPN
cbi-27	112	6	the	the	DET
cbi-27	112	7	input	input	NOUN
cbi-27	112	8	for	for	ADP
cbi-27	112	9	protein	protein	NOUN
cbi-27	112	10	translation	translation	NOUN
cbi-27	112	11	by	by	ADP
cbi-27	112	12	the	the	DET
cbi-27	112	13	ribosome	ribosome	NOUN
cbi-27	112	14	is	be	AUX
cbi-27	112	15	singlestranded	singlestrande	VERB
cbi-27	112	16	rna	rna	NOUN
cbi-27	112	17	,	,	PUNCT
cbi-27	112	18	also	also	ADV
cbi-27	112	19	called	call	VERB
cbi-27	112	20	messenger	messenger	PROPN
cbi-27	112	21	rna	rna	PROPN
cbi-27	112	22	.	.	PUNCT
cbi-27	113	1	the	the	DET
cbi-27	113	2	ribosome	ribosome	NOUN
cbi-27	113	3	is	be	AUX
cbi-27	113	4	the	the	DET
cbi-27	113	5	machinery	machinery	NOUN
cbi-27	113	6	that	that	PRON
cbi-27	113	7	does	do	VERB
cbi-27	113	8	the	the	DET
cbi-27	113	9	translation	translation	NOUN
cbi-27	113	10	and	and	CCONJ
cbi-27	113	11	adds	add	VERB
cbi-27	113	12	specific	specific	ADJ
cbi-27	113	13	amino	amino	NOUN
cbi-27	113	14	acids	acid	NOUN
cbi-27	113	15	based	base	VERB
cbi-27	113	16	on	on	ADP
cbi-27	113	17	the	the	DET
cbi-27	113	18	genetic	genetic	ADJ
cbi-27	113	19	code	code	NOUN
cbi-27	113	20	to	to	ADP
cbi-27	113	21	a	a	DET
cbi-27	113	22	growing	grow	VERB
cbi-27	113	23	chain	chain	NOUN
cbi-27	113	24	of	of	ADP
cbi-27	113	25	protein	protein	NOUN
cbi-27	113	26	.	.	PUNCT
cbi-27	114	1	as	as	SCONJ
cbi-27	114	2	we	we	PRON
cbi-27	114	3	have	have	AUX
cbi-27	114	4	seen	see	VERB
cbi-27	114	5	,	,	PUNCT
cbi-27	114	6	ribozymes	ribozyme	NOUN
cbi-27	114	7	can	can	AUX
cbi-27	114	8	also	also	ADV
cbi-27	114	9	be	be	AUX
cbi-27	114	10	derived	derive	VERB
cbi-27	114	11	from	from	ADP
cbi-27	114	12	double	double	ADJ
cbi-27	114	13	-	-	PUNCT
cbi-27	114	14	stranded	strand	VERB
cbi-27	114	15	dna	dna	NOUN
cbi-27	114	16	and	and	CCONJ
cbi-27	114	17	ribozymes	ribozyme	NOUN
cbi-27	114	18	could	could	AUX
cbi-27	114	19	thus	thus	ADV
cbi-27	114	20	have	have	AUX
cbi-27	114	21	been	be	AUX
cbi-27	114	22	involved	involve	VERB
cbi-27	114	23	in	in	ADP
cbi-27	114	24	the	the	DET
cbi-27	114	25	first	first	ADJ
cbi-27	114	26	translation	translation	NOUN
cbi-27	114	27	to	to	ADP
cbi-27	114	28	proteins	protein	NOUN
cbi-27	114	29	.	.	PUNCT
cbi-27	115	1	in	in	ADP
cbi-27	115	2	fact	fact	NOUN
cbi-27	115	3	,	,	PUNCT
cbi-27	115	4	the	the	DET
cbi-27	115	5	ribosome	ribosome	NOUN
cbi-27	115	6	has	have	VERB
cbi-27	115	7	many	many	ADJ
cbi-27	115	8	rna	rna	NOUN
cbi-27	115	9	components	component	NOUN
cbi-27	115	10	and	and	CCONJ
cbi-27	115	11	can	can	AUX
cbi-27	115	12	be	be	AUX
cbi-27	115	13	considered	consider	VERB
cbi-27	115	14	a	a	DET
cbi-27	115	15	ribozyme	ribozyme	NOUN
cbi-27	115	16	in	in	ADP
cbi-27	115	17	its	its	PRON
cbi-27	115	18	core	core	NOUN
cbi-27	115	19	.	.	PUNCT
cbi-27	116	1	for	for	ADP
cbi-27	116	2	evolution	evolution	NOUN
cbi-27	116	3	,	,	PUNCT
cbi-27	116	4	this	this	PRON
cbi-27	116	5	also	also	ADV
cbi-27	116	6	shows	show	VERB
cbi-27	116	7	a	a	DET
cbi-27	116	8	logical	logical	ADJ
cbi-27	116	9	sequence	sequence	NOUN
cbi-27	116	10	of	of	ADP
cbi-27	116	11	events	event	NOUN
cbi-27	116	12	,	,	PUNCT
cbi-27	116	13	where	where	SCONJ
cbi-27	116	14	first	first	ADJ
cbi-27	116	15	ribozymes	ribozyme	NOUN
cbi-27	116	16	were	be	AUX
cbi-27	116	17	derived	derive	VERB
cbi-27	116	18	from	from	ADP
cbi-27	116	19	the	the	DET
cbi-27	116	20	double	double	ADJ
cbi-27	116	21	-	-	PUNCT
cbi-27	116	22	stranded	strand	VERB
cbi-27	116	23	dna	dna	NOUN
cbi-27	116	24	template	template	NOUN
cbi-27	116	25	which	which	PRON
cbi-27	116	26	formed	form	VERB
cbi-27	116	27	the	the	DET
cbi-27	116	28	machinery	machinery	NOUN
cbi-27	116	29	to	to	PART
cbi-27	116	30	start	start	VERB
cbi-27	116	31	using	use	VERB
cbi-27	116	32	singlestranded	singlestrande	VERB
cbi-27	116	33	rna	rna	NOUN
cbi-27	116	34	as	as	ADP
cbi-27	116	35	a	a	DET
cbi-27	116	36	template	template	NOUN
cbi-27	116	37	for	for	ADP
cbi-27	116	38	proteins	protein	NOUN
cbi-27	116	39	.	.	PUNCT
cbi-27	117	1	here	here	ADV
cbi-27	117	2	we	we	PRON
cbi-27	117	3	see	see	VERB
cbi-27	117	4	that	that	SCONJ
cbi-27	117	5	the	the	DET
cbi-27	117	6	same	same	ADJ
cbi-27	117	7	template	template	NOUN
cbi-27	117	8	(	(	PUNCT
cbi-27	117	9	ssrna	ssrna	NOUN
cbi-27	117	10	)	)	PUNCT
cbi-27	117	11	can	can	AUX
cbi-27	117	12	be	be	AUX
cbi-27	117	13	used	use	VERB
cbi-27	117	14	to	to	PART
cbi-27	117	15	evolve	evolve	VERB
cbi-27	117	16	different	different	ADJ
cbi-27	117	17	functionalities	functionality	NOUN
cbi-27	117	18	while	while	SCONJ
cbi-27	117	19	keeping	keep	VERB
cbi-27	117	20	existing	exist	VERB
cbi-27	117	21	interfaces	interface	NOUN
cbi-27	117	22	intact	intact	ADJ
cbi-27	117	23	.	.	PUNCT
cbi-27	118	1	the	the	DET
cbi-27	118	2	evolution	evolution	NOUN
cbi-27	118	3	to	to	ADP
cbi-27	118	4	protein	protein	NOUN
cbi-27	118	5	generation	generation	NOUN
cbi-27	118	6	can	can	AUX
cbi-27	118	7	be	be	AUX
cbi-27	118	8	seen	see	VERB
cbi-27	118	9	as	as	ADP
cbi-27	118	10	an	an	DET
cbi-27	118	11	independent	independent	ADJ
cbi-27	118	12	functional	functional	ADJ
cbi-27	118	13	module	module	NOUN
cbi-27	118	14	.	.	PUNCT
cbi-27	119	1	3.7	3.7	NUM
cbi-27	119	2	evolution	evolution	NOUN
cbi-27	119	3	of	of	ADP
cbi-27	119	4	the	the	DET
cbi-27	119	5	dogma	dogma	NOUN
cbi-27	119	6	of	of	ADP
cbi-27	119	7	biology	biology	NOUN
cbi-27	119	8	if	if	SCONJ
cbi-27	119	9	we	we	PRON
cbi-27	119	10	look	look	VERB
cbi-27	119	11	at	at	ADP
cbi-27	119	12	the	the	DET
cbi-27	119	13	dependency	dependency	NOUN
cbi-27	119	14	and	and	CCONJ
cbi-27	119	15	the	the	DET
cbi-27	119	16	relations	relation	NOUN
cbi-27	119	17	between	between	ADP
cbi-27	119	18	the	the	DET
cbi-27	119	19	functional	functional	ADJ
cbi-27	119	20	modules	module	NOUN
cbi-27	119	21	of	of	ADP
cbi-27	119	22	the	the	DET
cbi-27	119	23	central	central	ADJ
cbi-27	119	24	dogma	dogma	NOUN
cbi-27	119	25	,	,	PUNCT
cbi-27	119	26	we	we	PRON
cbi-27	119	27	can	can	AUX
cbi-27	119	28	deduce	deduce	VERB
cbi-27	119	29	the	the	DET
cbi-27	119	30	volume	volume	NOUN
cbi-27	119	31	1	1	NUM
cbi-27	119	32	,	,	PUNCT
cbi-27	119	33	issue	issue	VERB
cbi-27	119	34	1	1	NUM
cbi-27	119	35	4	4	NUM
cbi-27	119	36	.	.	PUNCT
cbi-27	120	1	early	early	ADJ
cbi-27	120	2	genome	genome	NOUN
cbi-27	120	3	building	building	NOUN
cbi-27	120	4	9	9	NUM
cbi-27	120	5	sequence	sequence	NOUN
cbi-27	120	6	of	of	ADP
cbi-27	120	7	evolutionary	evolutionary	ADJ
cbi-27	120	8	events	event	NOUN
cbi-27	120	9	.	.	PUNCT
cbi-27	121	1	dna	dna	PROPN
cbi-27	121	2	is	be	AUX
cbi-27	121	3	transcribed	transcribe	VERB
cbi-27	121	4	into	into	ADP
cbi-27	121	5	rna	rna	PROPN
cbi-27	121	6	that	that	DET
cbi-27	121	7	functions	function	NOUN
cbi-27	121	8	as	as	ADP
cbi-27	121	9	the	the	DET
cbi-27	121	10	code	code	NOUN
cbi-27	121	11	(	(	PUNCT
cbi-27	121	12	interface	interface	NOUN
cbi-27	121	13	)	)	PUNCT
cbi-27	121	14	for	for	ADP
cbi-27	121	15	the	the	DET
cbi-27	121	16	proteins	protein	NOUN
cbi-27	121	17	translation	translation	NOUN
cbi-27	121	18	,	,	PUNCT
cbi-27	121	19	so	so	ADV
cbi-27	121	20	double	double	ADJ
cbi-27	121	21	-	-	PUNCT
cbi-27	121	22	stranded	strand	VERB
cbi-27	121	23	dna	dna	NOUN
cbi-27	121	24	had	have	VERB
cbi-27	121	25	to	to	PART
cbi-27	121	26	be	be	AUX
cbi-27	121	27	first	first	ADJ
cbi-27	121	28	to	to	PART
cbi-27	121	29	have	have	AUX
cbi-27	121	30	evolved	evolve	VERB
cbi-27	121	31	.	.	PUNCT
cbi-27	122	1	from	from	ADP
cbi-27	122	2	this	this	DET
cbi-27	122	3	initial	initial	ADJ
cbi-27	122	4	dna	dna	NOUN
cbi-27	122	5	,	,	PUNCT
cbi-27	122	6	single	single	ADJ
cbi-27	122	7	-	-	PUNCT
cbi-27	122	8	stranded	strand	VERB
cbi-27	122	9	rna	rna	NOUN
cbi-27	122	10	was	be	AUX
cbi-27	122	11	derived	derive	VERB
cbi-27	122	12	which	which	PRON
cbi-27	122	13	first	first	ADV
cbi-27	122	14	functioned	function	VERB
cbi-27	122	15	as	as	ADP
cbi-27	122	16	catalytic	catalytic	ADJ
cbi-27	122	17	rna	rna	NOUN
cbi-27	122	18	.	.	PUNCT
cbi-27	123	1	using	use	VERB
cbi-27	123	2	the	the	DET
cbi-27	123	3	catalytic	catalytic	ADJ
cbi-27	123	4	characteristics	characteristic	NOUN
cbi-27	123	5	of	of	ADP
cbi-27	123	6	single	single	ADJ
cbi-27	123	7	-	-	PUNCT
cbi-27	123	8	stranded	strand	VERB
cbi-27	123	9	rna	rna	NOUN
cbi-27	123	10	the	the	DET
cbi-27	123	11	first	first	ADJ
cbi-27	123	12	proteins	protein	NOUN
cbi-27	123	13	were	be	AUX
cbi-27	123	14	made	make	VERB
cbi-27	123	15	using	use	VERB
cbi-27	123	16	single	single	ADJ
cbi-27	123	17	-	-	PUNCT
cbi-27	123	18	stranded	strand	VERB
cbi-27	123	19	rna	rna	NOUN
cbi-27	123	20	(	(	PUNCT
cbi-27	123	21	mrna	mrna	PROPN
cbi-27	123	22	)	)	PUNCT
cbi-27	123	23	.	.	PUNCT
cbi-27	124	1	thus	thus	ADV
cbi-27	124	2	,	,	PUNCT
cbi-27	124	3	we	we	PRON
cbi-27	124	4	can	can	AUX
cbi-27	124	5	directly	directly	ADV
cbi-27	124	6	reverse	reverse	VERB
cbi-27	124	7	engineer	engineer	VERB
cbi-27	124	8	the	the	DET
cbi-27	124	9	steps	step	NOUN
cbi-27	124	10	in	in	ADP
cbi-27	124	11	evolution	evolution	NOUN
cbi-27	124	12	from	from	ADP
cbi-27	124	13	the	the	DET
cbi-27	124	14	developmental	developmental	ADJ
cbi-27	124	15	steps	step	NOUN
cbi-27	124	16	,	,	PUNCT
cbi-27	124	17	just	just	ADV
cbi-27	124	18	by	by	ADP
cbi-27	124	19	studying	study	VERB
cbi-27	124	20	the	the	DET
cbi-27	124	21	interfaces	interface	NOUN
cbi-27	124	22	and	and	CCONJ
cbi-27	124	23	their	their	PRON
cbi-27	124	24	dependencies	dependency	NOUN
cbi-27	124	25	.	.	PUNCT
cbi-27	125	1	the	the	DET
cbi-27	125	2	general	general	ADJ
cbi-27	125	3	rule	rule	NOUN
cbi-27	125	4	here	here	ADV
cbi-27	125	5	is	be	AUX
cbi-27	125	6	that	that	SCONJ
cbi-27	125	7	we	we	PRON
cbi-27	125	8	look	look	VERB
cbi-27	125	9	at	at	ADP
cbi-27	125	10	the	the	DET
cbi-27	125	11	flow	flow	NOUN
cbi-27	125	12	in	in	ADP
cbi-27	125	13	development	development	NOUN
cbi-27	125	14	steps	step	NOUN
cbi-27	125	15	(	(	PUNCT
cbi-27	125	16	dsdna	dsdna	ADV
cbi-27	125	17	to	to	PART
cbi-27	125	18	ssrna	ssrna	VERB
cbi-27	125	19	to	to	ADP
cbi-27	125	20	protein	protein	NOUN
cbi-27	125	21	)	)	PUNCT
cbi-27	125	22	to	to	PART
cbi-27	125	23	deduce	deduce	VERB
cbi-27	125	24	the	the	DET
cbi-27	125	25	evolutionary	evolutionary	ADJ
cbi-27	125	26	steps	step	NOUN
cbi-27	125	27	.	.	PUNCT
cbi-27	126	1	3.8	3.8	NUM
cbi-27	126	2	the	the	DET
cbi-27	126	3	first	first	ADJ
cbi-27	126	4	legacy	legacy	NOUN
cbi-27	126	5	system	system	NOUN
cbi-27	126	6	we	we	PRON
cbi-27	126	7	see	see	VERB
cbi-27	126	8	that	that	SCONJ
cbi-27	126	9	although	although	SCONJ
cbi-27	126	10	the	the	DET
cbi-27	126	11	implementation	implementation	NOUN
cbi-27	126	12	of	of	ADP
cbi-27	126	13	the	the	DET
cbi-27	126	14	functional	functional	ADJ
cbi-27	126	15	modules	module	NOUN
cbi-27	126	16	has	have	AUX
cbi-27	126	17	changed	change	VERB
cbi-27	126	18	,	,	PUNCT
cbi-27	126	19	their	their	PRON
cbi-27	126	20	interfaces	interface	NOUN
cbi-27	126	21	have	have	AUX
cbi-27	126	22	not	not	PART
cbi-27	126	23	changed	change	VERB
cbi-27	126	24	.	.	PUNCT
cbi-27	127	1	dna	dna	PROPN
cbi-27	127	2	replication	replication	NOUN
cbi-27	127	3	is	be	AUX
cbi-27	127	4	now	now	ADV
cbi-27	127	5	much	much	ADV
cbi-27	127	6	more	more	ADV
cbi-27	127	7	efficient	efficient	ADJ
cbi-27	127	8	than	than	ADP
cbi-27	127	9	in	in	ADP
cbi-27	127	10	the	the	DET
cbi-27	127	11	early	early	ADJ
cbi-27	127	12	years	year	NOUN
cbi-27	127	13	with	with	ADP
cbi-27	127	14	many	many	ADJ
cbi-27	127	15	more	more	ADJ
cbi-27	127	16	proteins	protein	NOUN
cbi-27	127	17	and	and	CCONJ
cbi-27	127	18	cofactors	cofactor	NOUN
cbi-27	127	19	involved	involve	VERB
cbi-27	127	20	,	,	PUNCT
cbi-27	127	21	but	but	CCONJ
cbi-27	127	22	the	the	DET
cbi-27	127	23	basic	basic	ADJ
cbi-27	127	24	interface	interface	NOUN
cbi-27	127	25	(	(	PUNCT
cbi-27	127	26	template	template	NOUN
cbi-27	127	27	-	-	PUNCT
cbi-27	127	28	based	base	VERB
cbi-27	127	29	replication	replication	NOUN
cbi-27	127	30	)	)	PUNCT
cbi-27	127	31	has	have	AUX
cbi-27	127	32	not	not	PART
cbi-27	127	33	changed	change	VERB
cbi-27	127	34	.	.	PUNCT
cbi-27	128	1	although	although	SCONJ
cbi-27	128	2	there	there	PRON
cbi-27	128	3	were	be	VERB
cbi-27	128	4	more	more	ADV
cbi-27	128	5	modern	modern	ADJ
cbi-27	128	6	and	and	CCONJ
cbi-27	128	7	efficient	efficient	ADJ
cbi-27	128	8	functions	function	NOUN
cbi-27	128	9	implemented	implement	VERB
cbi-27	128	10	over	over	ADP
cbi-27	128	11	time	time	NOUN
cbi-27	128	12	,	,	PUNCT
cbi-27	128	13	its	its	PRON
cbi-27	128	14	basic	basic	ADJ
cbi-27	128	15	interfaces	interface	NOUN
cbi-27	128	16	were	be	AUX
cbi-27	128	17	kept	keep	VERB
cbi-27	128	18	intact	intact	ADJ
cbi-27	128	19	.	.	PUNCT
cbi-27	129	1	once	once	SCONJ
cbi-27	129	2	the	the	DET
cbi-27	129	3	central	central	ADJ
cbi-27	129	4	dogma	dogma	NOUN
cbi-27	129	5	was	be	AUX
cbi-27	129	6	established	establish	VERB
cbi-27	129	7	all	all	DET
cbi-27	129	8	subsequent	subsequent	ADJ
cbi-27	129	9	functions	function	NOUN
cbi-27	129	10	,	,	PUNCT
cbi-27	129	11	whether	whether	SCONJ
cbi-27	129	12	it	it	PRON
cbi-27	129	13	is	be	AUX
cbi-27	129	14	bacterial	bacterial	ADJ
cbi-27	129	15	growth	growth	NOUN
cbi-27	129	16	or	or	CCONJ
cbi-27	129	17	the	the	DET
cbi-27	129	18	formation	formation	NOUN
cbi-27	129	19	of	of	ADP
cbi-27	129	20	multicellular	multicellular	ADJ
cbi-27	129	21	organism	organism	NOUN
cbi-27	129	22	would	would	AUX
cbi-27	129	23	depend	depend	VERB
cbi-27	129	24	on	on	ADP
cbi-27	129	25	the	the	DET
cbi-27	129	26	formation	formation	NOUN
cbi-27	129	27	of	of	ADP
cbi-27	129	28	catalytic	catalytic	ADJ
cbi-27	129	29	rna	rna	NOUN
cbi-27	129	30	and	and	CCONJ
cbi-27	129	31	proteins	protein	NOUN
cbi-27	129	32	.	.	PUNCT
cbi-27	130	1	in	in	ADP
cbi-27	130	2	all	all	DET
cbi-27	130	3	life	life	NOUN
cbi-27	130	4	forms	form	NOUN
cbi-27	130	5	,	,	PUNCT
cbi-27	130	6	the	the	DET
cbi-27	130	7	central	central	ADJ
cbi-27	130	8	dogma	dogma	NOUN
cbi-27	130	9	still	still	ADV
cbi-27	130	10	holds	hold	VERB
cbi-27	130	11	and	and	CCONJ
cbi-27	130	12	can	can	AUX
cbi-27	130	13	thus	thus	ADV
cbi-27	130	14	be	be	AUX
cbi-27	130	15	considered	consider	VERB
cbi-27	130	16	the	the	DET
cbi-27	130	17	first	first	ADJ
cbi-27	130	18	legacy	legacy	NOUN
cbi-27	130	19	system	system	NOUN
cbi-27	130	20	.	.	PUNCT
cbi-27	131	1	these	these	DET
cbi-27	131	2	basic	basic	ADJ
cbi-27	131	3	interfaces	interface	NOUN
cbi-27	131	4	simply	simply	ADV
cbi-27	131	5	could	could	AUX
cbi-27	131	6	never	never	ADV
cbi-27	131	7	change	change	VERB
cbi-27	131	8	because	because	SCONJ
cbi-27	131	9	it	it	PRON
cbi-27	131	10	would	would	AUX
cbi-27	131	11	break	break	VERB
cbi-27	131	12	the	the	DET
cbi-27	131	13	rule	rule	NOUN
cbi-27	131	14	of	of	ADP
cbi-27	131	15	functional	functional	ADJ
cbi-27	131	16	continuity	continuity	NOUN
cbi-27	131	17	.	.	PUNCT
cbi-27	132	1	everything	everything	PRON
cbi-27	132	2	else	else	ADV
cbi-27	132	3	is	be	AUX
cbi-27	132	4	based	base	VERB
cbi-27	132	5	on	on	ADP
cbi-27	132	6	these	these	DET
cbi-27	132	7	original	original	ADJ
cbi-27	132	8	and	and	CCONJ
cbi-27	132	9	additional	additional	ADJ
cbi-27	132	10	layers	layer	NOUN
cbi-27	132	11	of	of	ADP
cbi-27	132	12	functionality	functionality	NOUN
cbi-27	132	13	have	have	AUX
cbi-27	132	14	been	be	AUX
cbi-27	132	15	built	build	VERB
cbi-27	132	16	on	on	ADP
cbi-27	132	17	top	top	NOUN
cbi-27	132	18	of	of	ADP
cbi-27	132	19	this	this	PRON
cbi-27	132	20	,	,	PUNCT
cbi-27	132	21	as	as	SCONJ
cbi-27	132	22	you	you	PRON
cbi-27	132	23	would	would	AUX
cbi-27	132	24	expect	expect	VERB
cbi-27	132	25	in	in	ADP
cbi-27	132	26	a	a	DET
cbi-27	132	27	system	system	NOUN
cbi-27	132	28	that	that	PRON
cbi-27	132	29	is	be	AUX
cbi-27	132	30	based	base	VERB
cbi-27	132	31	on	on	ADP
cbi-27	132	32	a	a	DET
cbi-27	132	33	modular	modular	ADJ
cbi-27	132	34	design	design	NOUN
cbi-27	132	35	based	base	VERB
cbi-27	132	36	on	on	ADP
cbi-27	132	37	design	design	NOUN
cbi-27	132	38	-	-	PUNCT
cbi-27	132	39	by	by	ADP
cbi-27	132	40	-	-	PUNCT
cbi-27	132	41	contract	contract	NOUN
cbi-27	132	42	.	.	PUNCT
cbi-27	133	1	4	4	NUM
cbi-27	133	2	early	early	ADJ
cbi-27	133	3	genome	genome	NOUN
cbi-27	133	4	building	building	NOUN
cbi-27	133	5	design	design	NOUN
cbi-27	133	6	-	-	PUNCT
cbi-27	133	7	by	by	ADP
cbi-27	133	8	-	-	PUNCT
cbi-27	133	9	contract	contract	NOUN
cbi-27	133	10	divides	divide	VERB
cbi-27	133	11	a	a	DET
cbi-27	133	12	system	system	NOUN
cbi-27	133	13	into	into	ADP
cbi-27	133	14	functional	functional	ADJ
cbi-27	133	15	modules	module	NOUN
cbi-27	133	16	and	and	CCONJ
cbi-27	133	17	their	their	PRON
cbi-27	133	18	interfaces	interface	NOUN
cbi-27	133	19	.	.	PUNCT
cbi-27	134	1	the	the	DET
cbi-27	134	2	modules	module	NOUN
cbi-27	134	3	perform	perform	VERB
cbi-27	134	4	a	a	DET
cbi-27	134	5	certain	certain	ADJ
cbi-27	134	6	task	task	NOUN
cbi-27	134	7	in	in	ADP
cbi-27	134	8	the	the	DET
cbi-27	134	9	system	system	NOUN
cbi-27	134	10	and	and	CCONJ
cbi-27	134	11	communication	communication	NOUN
cbi-27	134	12	between	between	ADP
cbi-27	134	13	modules	module	NOUN
cbi-27	134	14	is	be	AUX
cbi-27	134	15	through	through	ADP
cbi-27	134	16	defined	define	VERB
cbi-27	134	17	interface	interface	NOUN
cbi-27	134	18	.	.	PUNCT
cbi-27	135	1	design	design	NOUN
cbi-27	135	2	-	-	PUNCT
cbi-27	135	3	by	by	ADP
cbi-27	135	4	-	-	PUNCT
cbi-27	135	5	contract	contract	NOUN
cbi-27	135	6	states	state	NOUN
cbi-27	135	7	that	that	SCONJ
cbi-27	135	8	these	these	DET
cbi-27	135	9	basic	basic	ADJ
cbi-27	135	10	interfaces	interface	NOUN
cbi-27	135	11	can	can	AUX
cbi-27	135	12	not	not	PART
cbi-27	135	13	be	be	AUX
cbi-27	135	14	changed	change	VERB
cbi-27	135	15	once	once	ADV
cbi-27	135	16	established	establish	VERB
cbi-27	135	17	and	and	CCONJ
cbi-27	135	18	we	we	PRON
cbi-27	135	19	applied	apply	VERB
cbi-27	135	20	this	this	DET
cbi-27	135	21	concept	concept	NOUN
cbi-27	135	22	to	to	ADP
cbi-27	135	23	the	the	DET
cbi-27	135	24	evolution	evolution	NOUN
cbi-27	135	25	of	of	ADP
cbi-27	135	26	the	the	DET
cbi-27	135	27	central	central	ADJ
cbi-27	135	28	dogma	dogma	NOUN
cbi-27	135	29	.	.	PUNCT
cbi-27	136	1	here	here	ADV
cbi-27	136	2	we	we	PRON
cbi-27	136	3	see	see	VERB
cbi-27	136	4	how	how	SCONJ
cbi-27	136	5	a	a	DET
cbi-27	136	6	complex	complex	ADJ
cbi-27	136	7	genome	genome	NOUN
cbi-27	136	8	can	can	AUX
cbi-27	136	9	be	be	AUX
cbi-27	136	10	formed	form	VERB
cbi-27	136	11	based	base	VERB
cbi-27	136	12	on	on	ADP
cbi-27	136	13	the	the	DET
cbi-27	136	14	central	central	ADJ
cbi-27	136	15	dogma	dogma	NOUN
cbi-27	136	16	while	while	SCONJ
cbi-27	136	17	applying	apply	VERB
cbi-27	136	18	designby	designby	NOUN
cbi-27	136	19	-	-	PUNCT
cbi-27	136	20	contract	contract	NOUN
cbi-27	136	21	and	and	CCONJ
cbi-27	136	22	the	the	DET
cbi-27	136	23	rule	rule	NOUN
cbi-27	136	24	of	of	ADP
cbi-27	136	25	functional	functional	ADJ
cbi-27	136	26	continuity	continuity	NOUN
cbi-27	136	27	.	.	PUNCT
cbi-27	137	1	4.1	4.1	NUM
cbi-27	137	2	exon	exon	NOUN
cbi-27	137	3	concatenation	concatenation	NOUN
cbi-27	137	4	if	if	SCONJ
cbi-27	137	5	we	we	PRON
cbi-27	137	6	look	look	VERB
cbi-27	137	7	at	at	ADP
cbi-27	137	8	dna	dna	NOUN
cbi-27	137	9	and	and	CCONJ
cbi-27	137	10	its	its	PRON
cbi-27	137	11	structure	structure	NOUN
cbi-27	137	12	,	,	PUNCT
cbi-27	137	13	there	there	PRON
cbi-27	137	14	is	be	VERB
cbi-27	137	15	a	a	DET
cbi-27	137	16	clear	clear	ADJ
cbi-27	137	17	modularity	modularity	NOUN
cbi-27	137	18	at	at	ADP
cbi-27	137	19	the	the	DET
cbi-27	137	20	gene	gene	NOUN
cbi-27	137	21	level	level	NOUN
cbi-27	137	22	.	.	PUNCT
cbi-27	138	1	the	the	DET
cbi-27	138	2	gene	gene	NOUN
cbi-27	138	3	as	as	ADP
cbi-27	138	4	a	a	DET
cbi-27	138	5	functional	functional	ADJ
cbi-27	138	6	module	module	NOUN
cbi-27	138	7	that	that	PRON
cbi-27	138	8	codes	code	VERB
cbi-27	138	9	for	for	ADP
cbi-27	138	10	a	a	DET
cbi-27	138	11	protein	protein	NOUN
cbi-27	138	12	and	and	CCONJ
cbi-27	138	13	its	its	PRON
cbi-27	138	14	interface	interface	NOUN
cbi-27	138	15	consists	consist	VERB
cbi-27	138	16	of	of	ADP
cbi-27	138	17	the	the	DET
cbi-27	138	18	promotor	promotor	NOUN
cbi-27	138	19	with	with	ADP
cbi-27	138	20	the	the	DET
cbi-27	138	21	start	start	NOUN
cbi-27	138	22	codon	codon	NOUN
cbi-27	138	23	and	and	CCONJ
cbi-27	138	24	the	the	DET
cbi-27	138	25	introns	intron	NOUN
cbi-27	138	26	and	and	CCONJ
cbi-27	138	27	the	the	DET
cbi-27	138	28	exons	exon	NOUN
cbi-27	138	29	.	.	PUNCT
cbi-27	139	1	within	within	ADP
cbi-27	139	2	the	the	DET
cbi-27	139	3	gene	gene	NOUN
cbi-27	139	4	,	,	PUNCT
cbi-27	139	5	the	the	DET
cbi-27	139	6	different	different	ADJ
cbi-27	139	7	exons	exon	NOUN
cbi-27	139	8	can	can	AUX
cbi-27	139	9	also	also	ADV
cbi-27	139	10	be	be	AUX
cbi-27	139	11	regarded	regard	VERB
cbi-27	139	12	as	as	ADP
cbi-27	139	13	functional	functional	ADJ
cbi-27	139	14	modules	module	NOUN
cbi-27	139	15	as	as	SCONJ
cbi-27	139	16	they	they	PRON
cbi-27	139	17	can	can	AUX
cbi-27	139	18	be	be	AUX
cbi-27	139	19	combined	combine	VERB
cbi-27	139	20	to	to	PART
cbi-27	139	21	give	give	VERB
cbi-27	139	22	different	different	ADJ
cbi-27	139	23	proteins	protein	NOUN
cbi-27	139	24	when	when	SCONJ
cbi-27	139	25	spliced	splice	VERB
cbi-27	139	26	into	into	ADP
cbi-27	139	27	an	an	DET
cbi-27	139	28	intronless	intronless	ADJ
cbi-27	139	29	mrna	mrna	NOUN
cbi-27	139	30	.	.	PUNCT
cbi-27	140	1	the	the	DET
cbi-27	140	2	splicing	splicing	NOUN
cbi-27	140	3	machinery	machinery	NOUN
cbi-27	140	4	as	as	ADP
cbi-27	140	5	functional	functional	ADJ
cbi-27	140	6	module	module	NOUN
cbi-27	140	7	has	have	VERB
cbi-27	140	8	a	a	DET
cbi-27	140	9	clear	clear	ADJ
cbi-27	140	10	interface	interface	NOUN
cbi-27	140	11	:	:	PUNCT
cbi-27	140	12	single	single	ADJ
cbi-27	140	13	-	-	PUNCT
cbi-27	140	14	stranded	strand	VERB
cbi-27	140	15	rna	rna	NOUN
cbi-27	140	16	with	with	ADP
cbi-27	140	17	introns	intron	NOUN
cbi-27	140	18	and	and	CCONJ
cbi-27	140	19	exons	exon	NOUN
cbi-27	140	20	are	be	AUX
cbi-27	140	21	used	use	VERB
cbi-27	140	22	as	as	ADP
cbi-27	140	23	the	the	DET
cbi-27	140	24	input	input	NOUN
cbi-27	140	25	and	and	CCONJ
cbi-27	140	26	messenger	messenger	NOUN
cbi-27	140	27	rna	rna	NOUN
cbi-27	140	28	without	without	ADP
cbi-27	140	29	introns	intron	NOUN
cbi-27	140	30	is	be	AUX
cbi-27	140	31	the	the	DET
cbi-27	140	32	result	result	NOUN
cbi-27	140	33	.	.	PUNCT
cbi-27	141	1	intron	intron	ADJ
cbi-27	141	2	splicing	splicing	NOUN
cbi-27	141	3	,	,	PUNCT
cbi-27	141	4	or	or	CCONJ
cbi-27	141	5	exon	exon	NOUN
cbi-27	141	6	concatenation	concatenation	NOUN
cbi-27	141	7	is	be	AUX
cbi-27	141	8	a	a	DET
cbi-27	141	9	way	way	NOUN
cbi-27	141	10	to	to	PART
cbi-27	141	11	form	form	VERB
cbi-27	141	12	complex	complex	ADJ
cbi-27	141	13	(	(	PUNCT
cbi-27	141	14	multi	multi	ADJ
cbi-27	141	15	-	-	ADJ
cbi-27	141	16	exon	exon	ADJ
cbi-27	141	17	)	)	PUNCT
cbi-27	141	18	genes	gene	NOUN
cbi-27	141	19	without	without	ADP
cbi-27	141	20	changing	change	VERB
cbi-27	141	21	the	the	DET
cbi-27	141	22	original	original	ADJ
cbi-27	141	23	interface	interface	NOUN
cbi-27	141	24	.	.	PUNCT
cbi-27	142	1	single	single	ADJ
cbi-27	142	2	-	-	PUNCT
cbi-27	142	3	stranded	strand	VERB
cbi-27	142	4	rna	rna	NOUN
cbi-27	142	5	is	be	AUX
cbi-27	142	6	still	still	ADV
cbi-27	142	7	derived	derive	VERB
cbi-27	142	8	from	from	ADP
cbi-27	142	9	the	the	DET
cbi-27	142	10	double	double	ADJ
cbi-27	142	11	-	-	PUNCT
cbi-27	142	12	stranded	strand	VERB
cbi-27	142	13	dna	dna	NOUN
cbi-27	142	14	and	and	CCONJ
cbi-27	142	15	the	the	DET
cbi-27	142	16	ribosome	ribosome	NOUN
cbi-27	142	17	still	still	ADV
cbi-27	142	18	works	work	VERB
cbi-27	142	19	with	with	ADP
cbi-27	142	20	the	the	DET
cbi-27	142	21	same	same	ADJ
cbi-27	142	22	template	template	NOUN
cbi-27	142	23	.	.	PUNCT
cbi-27	143	1	the	the	DET
cbi-27	143	2	concatenation	concatenation	NOUN
cbi-27	143	3	of	of	ADP
cbi-27	143	4	exons	exon	NOUN
cbi-27	143	5	creates	create	VERB
cbi-27	143	6	new	new	ADJ
cbi-27	143	7	multi	multi	ADJ
cbi-27	143	8	-	-	ADJ
cbi-27	143	9	exon	exon	ADJ
cbi-27	143	10	proteins	protein	NOUN
cbi-27	143	11	while	while	SCONJ
cbi-27	143	12	leaving	leave	VERB
cbi-27	143	13	all	all	DET
cbi-27	143	14	other	other	ADJ
cbi-27	143	15	systems	system	NOUN
cbi-27	143	16	intact	intact	ADJ
cbi-27	143	17	ensuring	ensure	VERB
cbi-27	143	18	functional	functional	ADJ
cbi-27	143	19	continuity	continuity	NOUN
cbi-27	143	20	.	.	PUNCT
cbi-27	144	1	4.2	4.2	NUM
cbi-27	144	2	exon	exon	NOUN
cbi-27	144	3	and	and	CCONJ
cbi-27	144	4	gene	gene	NOUN
cbi-27	144	5	shuffling	shuffle	VERB
cbi-27	144	6	once	once	ADV
cbi-27	144	7	the	the	DET
cbi-27	144	8	system	system	NOUN
cbi-27	144	9	has	have	AUX
cbi-27	144	10	evolved	evolve	VERB
cbi-27	144	11	multi	multi	ADJ
cbi-27	144	12	-	-	ADJ
cbi-27	144	13	exon	exon	ADJ
cbi-27	144	14	genes	gene	NOUN
cbi-27	144	15	,	,	PUNCT
cbi-27	144	16	further	further	ADJ
cbi-27	144	17	combinations	combination	NOUN
cbi-27	144	18	of	of	ADP
cbi-27	144	19	a	a	DET
cbi-27	144	20	limited	limited	ADJ
cbi-27	144	21	number	number	NOUN
cbi-27	144	22	of	of	ADP
cbi-27	144	23	functional	functional	ADJ
cbi-27	144	24	and	and	CCONJ
cbi-27	144	25	structural	structural	ADJ
cbi-27	144	26	exon	exon	NOUN
cbi-27	144	27	modules	module	NOUN
cbi-27	144	28	can	can	AUX
cbi-27	144	29	create	create	VERB
cbi-27	144	30	a	a	DET
cbi-27	144	31	large	large	ADJ
cbi-27	144	32	set	set	NOUN
cbi-27	144	33	of	of	ADP
cbi-27	144	34	different	different	ADJ
cbi-27	144	35	proteins	protein	NOUN
cbi-27	144	36	.	.	PUNCT
cbi-27	145	1	introns	intron	NOUN
cbi-27	145	2	and	and	CCONJ
cbi-27	145	3	other	other	ADJ
cbi-27	145	4	non	non	ADJ
cbi-27	145	5	-	-	ADJ
cbi-27	145	6	coding	code	VERB
cbi-27	145	7	sequences	sequence	NOUN
cbi-27	145	8	provide	provide	VERB
cbi-27	145	9	recombination	recombination	NOUN
cbi-27	145	10	points	point	NOUN
cbi-27	145	11	that	that	PRON
cbi-27	145	12	make	make	VERB
cbi-27	145	13	the	the	DET
cbi-27	145	14	shuffling	shuffling	NOUN
cbi-27	145	15	of	of	ADP
cbi-27	145	16	genes	gene	NOUN
cbi-27	145	17	and	and	CCONJ
cbi-27	145	18	exons	exon	NOUN
cbi-27	145	19	feasible	feasible	ADJ
cbi-27	145	20	.	.	PUNCT
cbi-27	146	1	higher	high	ADJ
cbi-27	146	2	level	level	NOUN
cbi-27	146	3	shuffling	shuffling	NOUN
cbi-27	146	4	can	can	AUX
cbi-27	146	5	be	be	AUX
cbi-27	146	6	performed	perform	VERB
cbi-27	146	7	when	when	SCONJ
cbi-27	146	8	complete	complete	ADJ
cbi-27	146	9	protein	protein	NOUN
cbi-27	146	10	modules	module	NOUN
cbi-27	146	11	composed	compose	VERB
cbi-27	146	12	of	of	ADP
cbi-27	146	13	multiple	multiple	ADJ
cbi-27	146	14	exons	exon	NOUN
cbi-27	146	15	are	be	AUX
cbi-27	146	16	shuffled	shuffle	VERB
cbi-27	146	17	made	make	VERB
cbi-27	146	18	possible	possible	ADJ
cbi-27	146	19	by	by	ADP
cbi-27	146	20	the	the	DET
cbi-27	146	21	modular	modular	ADJ
cbi-27	146	22	structure	structure	NOUN
cbi-27	146	23	of	of	ADP
cbi-27	146	24	genes	gene	NOUN
cbi-27	146	25	and	and	CCONJ
cbi-27	146	26	exons	exon	NOUN
cbi-27	146	27	.	.	PUNCT
cbi-27	147	1	the	the	DET
cbi-27	147	2	exons	exon	NOUN
cbi-27	147	3	are	be	AUX
cbi-27	147	4	recognizable	recognizable	ADJ
cbi-27	147	5	in	in	ADP
cbi-27	147	6	the	the	DET
cbi-27	147	7	strands	strand	NOUN
cbi-27	147	8	of	of	ADP
cbi-27	147	9	dna	dna	NOUN
cbi-27	147	10	by	by	ADP
cbi-27	147	11	a	a	DET
cbi-27	147	12	nucleotide	nucleotide	ADJ
cbi-27	147	13	sequence	sequence	NOUN
cbi-27	147	14	in	in	ADP
cbi-27	147	15	the	the	DET
cbi-27	147	16	intron	intron	NOUN
cbi-27	147	17	that	that	PRON
cbi-27	147	18	demarcates	demarcate	VERB
cbi-27	147	19	the	the	DET
cbi-27	147	20	exons	exon	NOUN
cbi-27	147	21	and	and	CCONJ
cbi-27	147	22	the	the	DET
cbi-27	147	23	entire	entire	ADJ
cbi-27	147	24	exon	exon	NOUN
cbi-27	147	25	modules	module	NOUN
cbi-27	147	26	would	would	AUX
cbi-27	147	27	function	function	VERB
cbi-27	147	28	in	in	ADP
cbi-27	147	29	another	another	DET
cbi-27	147	30	gene	gene	NOUN
cbi-27	147	31	.	.	PUNCT
cbi-27	148	1	transfer	transfer	NOUN
cbi-27	148	2	of	of	ADP
cbi-27	148	3	parts	part	NOUN
cbi-27	148	4	of	of	ADP
cbi-27	148	5	genes	gene	NOUN
cbi-27	148	6	with	with	ADP
cbi-27	148	7	their	their	PRON
cbi-27	148	8	promotor	promotor	NOUN
cbi-27	148	9	regions	region	NOUN
cbi-27	148	10	that	that	PRON
cbi-27	148	11	demarcate	demarcate	VERB
cbi-27	148	12	the	the	DET
cbi-27	148	13	start	start	NOUN
cbi-27	148	14	of	of	ADP
cbi-27	148	15	a	a	DET
cbi-27	148	16	gene	gene	NOUN
cbi-27	148	17	,	,	PUNCT
cbi-27	148	18	allow	allow	VERB
cbi-27	148	19	transferred	transfer	VERB
cbi-27	148	20	genes	gene	NOUN
cbi-27	148	21	to	to	PART
cbi-27	148	22	be	be	AUX
cbi-27	148	23	transcribed	transcribe	VERB
cbi-27	148	24	without	without	ADP
cbi-27	148	25	needing	need	VERB
cbi-27	148	26	extra	extra	ADJ
cbi-27	148	27	signals	signal	NOUN
cbi-27	148	28	.	.	PUNCT
cbi-27	149	1	the	the	DET
cbi-27	149	2	modular	modular	ADJ
cbi-27	149	3	structure	structure	NOUN
cbi-27	149	4	of	of	ADP
cbi-27	149	5	genes	gene	NOUN
cbi-27	149	6	thus	thus	ADV
cbi-27	149	7	allow	allow	VERB
cbi-27	149	8	for	for	ADP
cbi-27	149	9	quick	quick	ADJ
cbi-27	149	10	expansion	expansion	NOUN
cbi-27	149	11	of	of	ADP
cbi-27	149	12	the	the	DET
cbi-27	149	13	genome	genome	NOUN
cbi-27	149	14	and	and	CCONJ
cbi-27	149	15	its	its	PRON
cbi-27	149	16	concomitant	concomitant	ADJ
cbi-27	149	17	expression	expression	NOUN
cbi-27	149	18	of	of	ADP
cbi-27	149	19	proteins	protein	NOUN
cbi-27	149	20	.	.	PUNCT
cbi-27	150	1	4.3	4.3	NUM
cbi-27	150	2	posttranslational	posttranslational	ADJ
cbi-27	150	3	modifications	modification	NOUN
cbi-27	150	4	the	the	DET
cbi-27	150	5	ribosome	ribosome	NOUN
cbi-27	150	6	translates	translate	VERB
cbi-27	150	7	messenger	messenger	NOUN
cbi-27	150	8	rna	rna	NOUN
cbi-27	150	9	into	into	ADP
cbi-27	150	10	proteins	protein	NOUN
cbi-27	150	11	and	and	CCONJ
cbi-27	150	12	is	be	AUX
cbi-27	150	13	unaware	unaware	ADJ
cbi-27	150	14	whether	whether	SCONJ
cbi-27	150	15	the	the	DET
cbi-27	150	16	mrna	mrna	PROPN
cbi-27	150	17	contains	contain	VERB
cbi-27	150	18	introns	intron	NOUN
cbi-27	150	19	.	.	PUNCT
cbi-27	151	1	alternative	alternative	ADJ
cbi-27	151	2	splicing	splicing	NOUN
cbi-27	151	3	and	and	CCONJ
cbi-27	151	4	exon	exon	NOUN
cbi-27	151	5	shuffling	shuffling	NOUN
cbi-27	151	6	were	be	AUX
cbi-27	151	7	able	able	ADJ
cbi-27	151	8	to	to	PART
cbi-27	151	9	diversify	diversify	VERB
cbi-27	151	10	the	the	DET
cbi-27	151	11	number	number	NOUN
cbi-27	151	12	of	of	ADP
cbi-27	151	13	proteins	protein	NOUN
cbi-27	151	14	without	without	ADP
cbi-27	151	15	affecting	affect	VERB
cbi-27	151	16	protein	protein	NOUN
cbi-27	151	17	translation	translation	NOUN
cbi-27	151	18	itself	itself	PRON
cbi-27	151	19	.	.	PUNCT
cbi-27	152	1	also	also	ADV
cbi-27	152	2	after	after	ADP
cbi-27	152	3	translation	translation	NOUN
cbi-27	152	4	,	,	PUNCT
cbi-27	152	5	the	the	DET
cbi-27	152	6	cell	cell	NOUN
cbi-27	152	7	has	have	AUX
cbi-27	152	8	evolved	evolve	VERB
cbi-27	152	9	mechanisms	mechanism	NOUN
cbi-27	152	10	to	to	PART
cbi-27	152	11	expand	expand	VERB
cbi-27	152	12	the	the	DET
cbi-27	152	13	total	total	ADJ
cbi-27	152	14	number	number	NOUN
cbi-27	152	15	of	of	ADP
cbi-27	152	16	functions	function	NOUN
cbi-27	152	17	of	of	ADP
cbi-27	152	18	proteins	protein	NOUN
cbi-27	152	19	by	by	ADP
cbi-27	152	20	posttranslational	posttranslational	ADJ
cbi-27	152	21	modifications	modification	NOUN
cbi-27	152	22	,	,	PUNCT
cbi-27	152	23	for	for	ADP
cbi-27	152	24	instance	instance	NOUN
cbi-27	152	25	by	by	ADP
cbi-27	152	26	adding	add	VERB
cbi-27	152	27	several	several	ADJ
cbi-27	152	28	chemical	chemical	ADJ
cbi-27	152	29	groups	group	NOUN
cbi-27	152	30	.	.	PUNCT
cbi-27	153	1	using	use	VERB
cbi-27	153	2	the	the	DET
cbi-27	153	3	original	original	ADJ
cbi-27	153	4	machinery	machinery	NOUN
cbi-27	153	5	that	that	PRON
cbi-27	153	6	transcribes	transcribe	VERB
cbi-27	153	7	mrna	mrna	PROPN
cbi-27	153	8	from	from	ADP
cbi-27	153	9	dna	dna	PROPN
cbi-27	153	10	and	and	CCONJ
cbi-27	153	11	that	that	PRON
cbi-27	153	12	translates	translate	VERB
cbi-27	153	13	mrna	mrna	NOUN
cbi-27	153	14	to	to	ADP
cbi-27	153	15	10	10	NUM
cbi-27	153	16	a	a	DET
cbi-27	153	17	proposed	propose	VERB
cbi-27	153	18	framework	framework	NOUN
cbi-27	153	19	for	for	ADP
cbi-27	153	20	cellular	cellular	ADJ
cbi-27	153	21	evolution	evolution	NOUN
cbi-27	153	22	proteins	protein	NOUN
cbi-27	153	23	,	,	PUNCT
cbi-27	153	24	an	an	DET
cbi-27	153	25	enormous	enormous	ADJ
cbi-27	153	26	diversity	diversity	NOUN
cbi-27	153	27	of	of	ADP
cbi-27	153	28	proteins	protein	NOUN
cbi-27	153	29	can	can	AUX
cbi-27	153	30	be	be	AUX
cbi-27	153	31	created	create	VERB
cbi-27	153	32	without	without	ADP
cbi-27	153	33	changing	change	VERB
cbi-27	153	34	these	these	DET
cbi-27	153	35	basic	basic	ADJ
cbi-27	153	36	steps	step	NOUN
cbi-27	153	37	.	.	PUNCT
cbi-27	154	1	this	this	PRON
cbi-27	154	2	is	be	AUX
cbi-27	154	3	done	do	VERB
cbi-27	154	4	by	by	ADP
cbi-27	154	5	leaving	leave	VERB
cbi-27	154	6	the	the	DET
cbi-27	154	7	earlier	early	ADJ
cbi-27	154	8	interfaces	interface	NOUN
cbi-27	154	9	intact	intact	ADJ
cbi-27	154	10	in	in	ADP
cbi-27	154	11	line	line	NOUN
cbi-27	154	12	with	with	ADP
cbi-27	154	13	the	the	DET
cbi-27	154	14	design	design	NOUN
cbi-27	154	15	-	-	PUNCT
cbi-27	154	16	bycontract	bycontract	NOUN
cbi-27	154	17	paradigm	paradigm	NOUN
cbi-27	154	18	and	and	CCONJ
cbi-27	154	19	adding	add	VERB
cbi-27	154	20	extra	extra	ADJ
cbi-27	154	21	functionality	functionality	NOUN
cbi-27	154	22	on	on	ADP
cbi-27	154	23	top	top	NOUN
cbi-27	154	24	of	of	ADP
cbi-27	154	25	the	the	DET
cbi-27	154	26	existing	exist	VERB
cbi-27	154	27	system	system	NOUN
cbi-27	154	28	.	.	PUNCT
cbi-27	155	1	4.4	4.4	NUM
cbi-27	155	2	an	an	DET
cbi-27	155	3	expanding	expand	VERB
cbi-27	155	4	molecular	molecular	ADJ
cbi-27	155	5	system	system	NOUN
cbi-27	155	6	in	in	ADP
cbi-27	155	7	eukaryotic	eukaryotic	ADJ
cbi-27	155	8	cells	cell	NOUN
cbi-27	155	9	,	,	PUNCT
cbi-27	155	10	there	there	PRON
cbi-27	155	11	are	be	VERB
cbi-27	155	12	mechanisms	mechanism	NOUN
cbi-27	155	13	for	for	ADP
cbi-27	155	14	splicing	splicing	NOUN
cbi-27	155	15	and	and	CCONJ
cbi-27	155	16	alternative	alternative	ADJ
cbi-27	155	17	splicing	splicing	NOUN
cbi-27	155	18	,	,	PUNCT
cbi-27	155	19	but	but	CCONJ
cbi-27	155	20	also	also	ADV
cbi-27	155	21	for	for	ADP
cbi-27	155	22	gene	gene	NOUN
cbi-27	155	23	recombination	recombination	NOUN
cbi-27	155	24	and	and	CCONJ
cbi-27	155	25	gene	gene	NOUN
cbi-27	155	26	hopping	hopping	NOUN
cbi-27	155	27	.	.	PUNCT
cbi-27	156	1	these	these	DET
cbi-27	156	2	mechanisms	mechanism	NOUN
cbi-27	156	3	can	can	AUX
cbi-27	156	4	be	be	AUX
cbi-27	156	5	seen	see	VERB
cbi-27	156	6	as	as	ADP
cbi-27	156	7	the	the	DET
cbi-27	156	8	vehicles	vehicle	NOUN
cbi-27	156	9	for	for	ADP
cbi-27	156	10	the	the	DET
cbi-27	156	11	evolution	evolution	NOUN
cbi-27	156	12	of	of	ADP
cbi-27	156	13	new	new	ADJ
cbi-27	156	14	proteins	protein	NOUN
cbi-27	156	15	.	.	PUNCT
cbi-27	157	1	active	active	ADJ
cbi-27	157	2	mechanisms	mechanism	NOUN
cbi-27	157	3	for	for	ADP
cbi-27	157	4	gene	gene	NOUN
cbi-27	157	5	recombination	recombination	NOUN
cbi-27	157	6	could	could	AUX
cbi-27	157	7	have	have	AUX
cbi-27	157	8	quickly	quickly	ADV
cbi-27	157	9	generated	generate	VERB
cbi-27	157	10	a	a	DET
cbi-27	157	11	diverse	diverse	ADJ
cbi-27	157	12	gene	gene	NOUN
cbi-27	157	13	population	population	NOUN
cbi-27	157	14	with	with	ADP
cbi-27	157	15	only	only	ADV
cbi-27	157	16	a	a	DET
cbi-27	157	17	limited	limited	ADJ
cbi-27	157	18	set	set	NOUN
cbi-27	157	19	of	of	ADP
cbi-27	157	20	functional	functional	ADJ
cbi-27	157	21	exon	exon	NOUN
cbi-27	157	22	modules	module	NOUN
cbi-27	157	23	.	.	PUNCT
cbi-27	158	1	there	there	PRON
cbi-27	158	2	could	could	AUX
cbi-27	158	3	also	also	ADV
cbi-27	158	4	be	be	AUX
cbi-27	158	5	many	many	ADJ
cbi-27	158	6	other	other	ADJ
cbi-27	158	7	active	active	ADJ
cbi-27	158	8	processes	process	NOUN
cbi-27	158	9	that	that	PRON
cbi-27	158	10	are	be	AUX
cbi-27	158	11	involved	involve	VERB
cbi-27	158	12	in	in	ADP
cbi-27	158	13	an	an	DET
cbi-27	158	14	active	active	ADJ
cbi-27	158	15	expansion	expansion	NOUN
cbi-27	158	16	of	of	ADP
cbi-27	158	17	the	the	DET
cbi-27	158	18	genome	genome	NOUN
cbi-27	158	19	during	during	ADP
cbi-27	158	20	evolution	evolution	NOUN
cbi-27	158	21	.	.	PUNCT
cbi-27	159	1	crossing	crossing	NOUN
cbi-27	159	2	-	-	PUNCT
cbi-27	159	3	over	over	ADP
cbi-27	159	4	during	during	ADP
cbi-27	159	5	meiosis	meiosis	NOUN
cbi-27	159	6	in	in	ADP
cbi-27	159	7	the	the	DET
cbi-27	159	8	germ	germ	NOUN
cbi-27	159	9	line	line	NOUN
cbi-27	159	10	cells	cell	NOUN
cbi-27	159	11	is	be	AUX
cbi-27	159	12	mechanism	mechanism	NOUN
cbi-27	159	13	that	that	PRON
cbi-27	159	14	creates	create	VERB
cbi-27	159	15	recombinations	recombination	NOUN
cbi-27	159	16	.	.	PUNCT
cbi-27	160	1	there	there	PRON
cbi-27	160	2	are	be	VERB
cbi-27	160	3	enzymes	enzyme	NOUN
cbi-27	160	4	(	(	PUNCT
cbi-27	160	5	telomerases	telomerase	NOUN
cbi-27	160	6	)	)	PUNCT
cbi-27	160	7	that	that	PRON
cbi-27	160	8	are	be	AUX
cbi-27	160	9	involved	involve	VERB
cbi-27	160	10	in	in	ADP
cbi-27	160	11	extension	extension	NOUN
cbi-27	160	12	of	of	ADP
cbi-27	160	13	the	the	DET
cbi-27	160	14	chromosomes	chromosome	NOUN
cbi-27	160	15	and	and	CCONJ
cbi-27	160	16	they	they	PRON
cbi-27	160	17	could	could	AUX
cbi-27	160	18	have	have	AUX
cbi-27	160	19	created	create	VERB
cbi-27	160	20	space	space	NOUN
cbi-27	160	21	for	for	ADP
cbi-27	160	22	new	new	ADJ
cbi-27	160	23	proteins	protein	NOUN
cbi-27	160	24	.	.	PUNCT
cbi-27	161	1	facilitated	facilitate	VERB
cbi-27	161	2	by	by	ADP
cbi-27	161	3	the	the	DET
cbi-27	161	4	modular	modular	ADJ
cbi-27	161	5	structure	structure	NOUN
cbi-27	161	6	of	of	ADP
cbi-27	161	7	the	the	DET
cbi-27	161	8	genome	genome	NOUN
cbi-27	161	9	,	,	PUNCT
cbi-27	161	10	active	active	ADJ
cbi-27	161	11	recombination	recombination	NOUN
cbi-27	161	12	mechanisms	mechanism	NOUN
cbi-27	161	13	can	can	AUX
cbi-27	161	14	drive	drive	VERB
cbi-27	161	15	genome	genome	NOUN
cbi-27	161	16	while	while	SCONJ
cbi-27	161	17	maintaining	maintain	VERB
cbi-27	161	18	functional	functional	ADJ
cbi-27	161	19	continuity	continuity	NOUN
cbi-27	161	20	.	.	PUNCT
cbi-27	162	1	in	in	ADP
cbi-27	162	2	other	other	ADJ
cbi-27	162	3	words	word	NOUN
cbi-27	162	4	,	,	PUNCT
cbi-27	162	5	due	due	ADP
cbi-27	162	6	to	to	ADP
cbi-27	162	7	active	active	ADJ
cbi-27	162	8	gene	gene	NOUN
cbi-27	162	9	recombination	recombination	NOUN
cbi-27	162	10	mechanisms	mechanism	NOUN
cbi-27	162	11	,	,	PUNCT
cbi-27	162	12	the	the	DET
cbi-27	162	13	genome	genome	NOUN
cbi-27	162	14	can	can	AUX
cbi-27	162	15	be	be	AUX
cbi-27	162	16	considered	consider	VERB
cbi-27	162	17	to	to	PART
cbi-27	162	18	be	be	AUX
cbi-27	162	19	self	self	NOUN
cbi-27	162	20	-	-	PUNCT
cbi-27	162	21	evolving	evolve	VERB
cbi-27	162	22	.	.	NOUN
cbi-27	162	23	5	5	NUM
cbi-27	163	1	the	the	DET
cbi-27	163	2	origin	origin	NOUN
cbi-27	163	3	of	of	ADP
cbi-27	163	4	the	the	DET
cbi-27	163	5	nucleus	nucleus	NOUN
cbi-27	163	6	the	the	DET
cbi-27	163	7	nucleus	nucleus	NOUN
cbi-27	163	8	is	be	AUX
cbi-27	163	9	a	a	DET
cbi-27	163	10	membrane	membrane	NOUN
cbi-27	163	11	-	-	PUNCT
cbi-27	163	12	enclosed	enclose	VERB
cbi-27	163	13	organelle	organelle	NOUN
cbi-27	163	14	found	find	VERB
cbi-27	163	15	in	in	ADP
cbi-27	163	16	all	all	DET
cbi-27	163	17	eukaryotic	eukaryotic	ADJ
cbi-27	163	18	cells	cell	NOUN
cbi-27	163	19	.	.	PUNCT
cbi-27	164	1	it	it	PRON
cbi-27	164	2	contains	contain	VERB
cbi-27	164	3	most	most	ADJ
cbi-27	164	4	of	of	ADP
cbi-27	164	5	the	the	DET
cbi-27	164	6	cell	cell	NOUN
cbi-27	164	7	’s	’s	PART
cbi-27	164	8	genetic	genetic	ADJ
cbi-27	164	9	material	material	NOUN
cbi-27	164	10	,	,	PUNCT
cbi-27	164	11	organized	organize	VERB
cbi-27	164	12	as	as	ADP
cbi-27	164	13	multiple	multiple	ADJ
cbi-27	164	14	long	long	ADJ
cbi-27	164	15	linear	linear	NOUN
cbi-27	164	16	dna	dna	PROPN
cbi-27	164	17	molecules	molecule	NOUN
cbi-27	164	18	in	in	ADP
cbi-27	164	19	a	a	DET
cbi-27	164	20	complex	complex	NOUN
cbi-27	164	21	with	with	ADP
cbi-27	164	22	a	a	DET
cbi-27	164	23	large	large	ADJ
cbi-27	164	24	variety	variety	NOUN
cbi-27	164	25	of	of	ADP
cbi-27	164	26	proteins	protein	NOUN
cbi-27	164	27	,	,	PUNCT
cbi-27	164	28	such	such	ADJ
cbi-27	164	29	as	as	ADP
cbi-27	164	30	histones	histone	NOUN
cbi-27	164	31	,	,	PUNCT
cbi-27	164	32	to	to	PART
cbi-27	164	33	form	form	VERB
cbi-27	164	34	chromosomes	chromosome	NOUN
cbi-27	164	35	.	.	PUNCT
cbi-27	165	1	the	the	DET
cbi-27	165	2	genes	gene	NOUN
cbi-27	165	3	within	within	ADP
cbi-27	165	4	these	these	DET
cbi-27	165	5	chromosomes	chromosome	NOUN
cbi-27	165	6	are	be	AUX
cbi-27	165	7	the	the	DET
cbi-27	165	8	cell	cell	NOUN
cbi-27	165	9	’s	’s	PART
cbi-27	165	10	nuclear	nuclear	ADJ
cbi-27	165	11	genome	genome	NOUN
cbi-27	165	12	.	.	PUNCT
cbi-27	166	1	the	the	DET
cbi-27	166	2	main	main	ADJ
cbi-27	166	3	structures	structure	NOUN
cbi-27	166	4	making	make	VERB
cbi-27	166	5	up	up	ADP
cbi-27	166	6	the	the	DET
cbi-27	166	7	nucleus	nucleus	NOUN
cbi-27	166	8	are	be	AUX
cbi-27	166	9	the	the	DET
cbi-27	166	10	nucleolus	nucleolus	NOUN
cbi-27	166	11	,	,	PUNCT
cbi-27	166	12	the	the	DET
cbi-27	166	13	nuclear	nuclear	ADJ
cbi-27	166	14	envelope	envelope	NOUN
cbi-27	166	15	and	and	CCONJ
cbi-27	166	16	the	the	DET
cbi-27	166	17	nucleoskeleton	nucleoskeleton	NOUN
cbi-27	166	18	(	(	PUNCT
cbi-27	166	19	which	which	PRON
cbi-27	166	20	includes	include	VERB
cbi-27	166	21	nuclear	nuclear	ADJ
cbi-27	166	22	lamina	lamina	NOUN
cbi-27	166	23	)	)	PUNCT
cbi-27	166	24	.	.	PUNCT
cbi-27	167	1	the	the	DET
cbi-27	167	2	structure	structure	NOUN
cbi-27	167	3	and	and	CCONJ
cbi-27	167	4	relationship	relationship	NOUN
cbi-27	167	5	between	between	ADP
cbi-27	167	6	these	these	DET
cbi-27	167	7	functional	functional	ADJ
cbi-27	167	8	units	unit	NOUN
cbi-27	167	9	and	and	CCONJ
cbi-27	167	10	the	the	DET
cbi-27	167	11	nucleus	nucleus	NOUN
cbi-27	167	12	can	can	AUX
cbi-27	167	13	give	give	VERB
cbi-27	167	14	insight	insight	NOUN
cbi-27	167	15	in	in	ADP
cbi-27	167	16	the	the	DET
cbi-27	167	17	stepwise	stepwise	ADJ
cbi-27	167	18	evolution	evolution	NOUN
cbi-27	167	19	of	of	ADP
cbi-27	167	20	the	the	DET
cbi-27	167	21	nucleus	nucleus	NOUN
cbi-27	167	22	.	.	PUNCT
cbi-27	168	1	5.1	5.1	NUM
cbi-27	168	2	the	the	DET
cbi-27	168	3	nucleolus	nucleolus	NOUN
cbi-27	168	4	as	as	ADP
cbi-27	168	5	first	first	ADV
cbi-27	168	6	replicating	replicate	VERB
cbi-27	168	7	unit	unit	NOUN
cbi-27	168	8	in	in	ADP
cbi-27	168	9	the	the	DET
cbi-27	168	10	evolution	evolution	NOUN
cbi-27	168	11	of	of	ADP
cbi-27	168	12	the	the	DET
cbi-27	168	13	nucleus	nucleus	NOUN
cbi-27	168	14	,	,	PUNCT
cbi-27	168	15	we	we	PRON
cbi-27	168	16	start	start	VERB
cbi-27	168	17	with	with	ADP
cbi-27	168	18	replicating	replicate	VERB
cbi-27	168	19	strands	strand	NOUN
cbi-27	168	20	of	of	ADP
cbi-27	168	21	dna	dna	NOUN
cbi-27	168	22	that	that	PRON
cbi-27	168	23	can	can	AUX
cbi-27	168	24	produce	produce	VERB
cbi-27	168	25	ribozymes	ribozyme	NOUN
cbi-27	168	26	and	and	CCONJ
cbi-27	168	27	proteins	protein	NOUN
cbi-27	168	28	as	as	SCONJ
cbi-27	168	29	we	we	PRON
cbi-27	168	30	have	have	AUX
cbi-27	168	31	discussed	discuss	VERB
cbi-27	168	32	in	in	ADP
cbi-27	168	33	the	the	DET
cbi-27	168	34	previous	previous	ADJ
cbi-27	168	35	chapter	chapter	NOUN
cbi-27	168	36	.	.	PUNCT
cbi-27	169	1	we	we	PRON
cbi-27	169	2	can	can	AUX
cbi-27	169	3	relatively	relatively	ADV
cbi-27	169	4	easy	easy	ADJ
cbi-27	169	5	start	start	VERB
cbi-27	169	6	extending	extend	VERB
cbi-27	169	7	this	this	DET
cbi-27	169	8	system	system	NOUN
cbi-27	169	9	into	into	ADP
cbi-27	169	10	a	a	DET
cbi-27	169	11	more	more	ADV
cbi-27	169	12	complicated	complicated	ADJ
cbi-27	169	13	structure	structure	NOUN
cbi-27	169	14	by	by	ADP
cbi-27	169	15	adding	add	VERB
cbi-27	169	16	a	a	DET
cbi-27	169	17	microenvironment	microenvironment	NOUN
cbi-27	169	18	of	of	ADP
cbi-27	169	19	protein	protein	NOUN
cbi-27	169	20	fibers	fiber	NOUN
cbi-27	169	21	,	,	PUNCT
cbi-27	169	22	dna	dna	NOUN
cbi-27	169	23	,	,	PUNCT
cbi-27	169	24	ribozymes	ribozyme	NOUN
cbi-27	169	25	and	and	CCONJ
cbi-27	169	26	ribosome	ribosome	NOUN
cbi-27	169	27	components	component	NOUN
cbi-27	169	28	.	.	PUNCT
cbi-27	170	1	proteins	protein	NOUN
cbi-27	170	2	can	can	AUX
cbi-27	170	3	give	give	VERB
cbi-27	170	4	the	the	DET
cbi-27	170	5	dna	dna	PROPN
cbi-27	170	6	structural	structural	ADJ
cbi-27	170	7	support	support	NOUN
cbi-27	170	8	and	and	CCONJ
cbi-27	170	9	that	that	PRON
cbi-27	170	10	create	create	VERB
cbi-27	170	11	a	a	DET
cbi-27	170	12	microenvironment	microenvironment	NOUN
cbi-27	170	13	that	that	PRON
cbi-27	170	14	would	would	AUX
cbi-27	170	15	facilitate	facilitate	VERB
cbi-27	170	16	duplication	duplication	NOUN
cbi-27	170	17	.	.	PUNCT
cbi-27	171	1	the	the	DET
cbi-27	171	2	nuclear	nuclear	ADJ
cbi-27	171	3	matrix	matrix	NOUN
cbi-27	171	4	,	,	PUNCT
cbi-27	171	5	a	a	DET
cbi-27	171	6	scaffold	scaffold	NOUN
cbi-27	171	7	of	of	ADP
cbi-27	171	8	proteins	protein	NOUN
cbi-27	171	9	could	could	AUX
cbi-27	171	10	serve	serve	VERB
cbi-27	171	11	as	as	ADP
cbi-27	171	12	such	such	DET
cbi-27	171	13	a	a	DET
cbi-27	171	14	protective	protective	ADJ
cbi-27	171	15	layer	layer	NOUN
cbi-27	171	16	around	around	ADP
cbi-27	171	17	the	the	DET
cbi-27	171	18	dna	dna	NOUN
cbi-27	171	19	and	and	CCONJ
cbi-27	171	20	would	would	AUX
cbi-27	171	21	lead	lead	VERB
cbi-27	171	22	to	to	ADP
cbi-27	171	23	a	a	DET
cbi-27	171	24	structure	structure	NOUN
cbi-27	171	25	that	that	PRON
cbi-27	171	26	we	we	PRON
cbi-27	171	27	now	now	ADV
cbi-27	171	28	call	call	VERB
cbi-27	171	29	the	the	DET
cbi-27	171	30	nucleolus	nucleolus	NOUN
cbi-27	171	31	.	.	PUNCT
cbi-27	172	1	such	such	DET
cbi-27	172	2	a	a	DET
cbi-27	172	3	system	system	NOUN
cbi-27	172	4	that	that	PRON
cbi-27	172	5	is	be	AUX
cbi-27	172	6	based	base	VERB
cbi-27	172	7	on	on	ADP
cbi-27	172	8	the	the	DET
cbi-27	172	9	protein	protein	NOUN
cbi-27	172	10	components	component	NOUN
cbi-27	172	11	that	that	SCONJ
cbi-27	172	12	the	the	DET
cbi-27	172	13	early	early	ADJ
cbi-27	172	14	translation	translation	NOUN
cbi-27	172	15	machinery	machinery	NOUN
cbi-27	172	16	can	can	AUX
cbi-27	172	17	produce	produce	VERB
cbi-27	172	18	would	would	AUX
cbi-27	172	19	be	be	AUX
cbi-27	172	20	the	the	DET
cbi-27	172	21	first	first	ADJ
cbi-27	172	22	step	step	NOUN
cbi-27	172	23	to	to	ADP
cbi-27	172	24	a	a	DET
cbi-27	172	25	primitive	primitive	ADJ
cbi-27	172	26	cell	cell	NOUN
cbi-27	172	27	.	.	PUNCT
cbi-27	173	1	this	this	DET
cbi-27	173	2	nucleolus	nucleolus	NOUN
cbi-27	173	3	would	would	AUX
cbi-27	173	4	be	be	AUX
cbi-27	173	5	composed	compose	VERB
cbi-27	173	6	of	of	ADP
cbi-27	173	7	a	a	DET
cbi-27	173	8	pool	pool	NOUN
cbi-27	173	9	of	of	ADP
cbi-27	173	10	dna	dna	NOUN
cbi-27	173	11	that	that	PRON
cbi-27	173	12	produces	produce	VERB
cbi-27	173	13	its	its	PRON
cbi-27	173	14	own	own	ADJ
cbi-27	173	15	individual	individual	ADJ
cbi-27	173	16	environment	environment	NOUN
cbi-27	173	17	.	.	PUNCT
cbi-27	174	1	5.2	5.2	NUM
cbi-27	174	2	the	the	DET
cbi-27	174	3	appearance	appearance	NOUN
cbi-27	174	4	of	of	ADP
cbi-27	174	5	the	the	DET
cbi-27	174	6	nuclear	nuclear	ADJ
cbi-27	174	7	lamina	lamina	NOUN
cbi-27	174	8	from	from	ADP
cbi-27	174	9	the	the	DET
cbi-27	174	10	nucleolus	nucleolus	NOUN
cbi-27	174	11	as	as	ADP
cbi-27	174	12	the	the	DET
cbi-27	174	13	first	first	ADJ
cbi-27	174	14	compartmentalized	compartmentalized	ADJ
cbi-27	174	15	structure	structure	NOUN
cbi-27	174	16	that	that	PRON
cbi-27	174	17	contains	contain	VERB
cbi-27	174	18	dna	dna	PROPN
cbi-27	174	19	,	,	PUNCT
cbi-27	174	20	the	the	DET
cbi-27	174	21	next	next	ADJ
cbi-27	174	22	layer	layer	NOUN
cbi-27	174	23	would	would	AUX
cbi-27	174	24	be	be	AUX
cbi-27	174	25	the	the	DET
cbi-27	174	26	extension	extension	NOUN
cbi-27	174	27	of	of	ADP
cbi-27	174	28	nuclear	nuclear	ADJ
cbi-27	174	29	matric	matric	NOUN
cbi-27	174	30	proteins	protein	NOUN
cbi-27	174	31	around	around	ADP
cbi-27	174	32	the	the	DET
cbi-27	174	33	nucleolus	nucleolus	NOUN
cbi-27	174	34	.	.	PUNCT
cbi-27	175	1	the	the	DET
cbi-27	175	2	nuclear	nuclear	ADJ
cbi-27	175	3	matrix	matrix	NOUN
cbi-27	175	4	is	be	AUX
cbi-27	175	5	a	a	DET
cbi-27	175	6	scaffold	scaffold	NOUN
cbi-27	175	7	of	of	ADP
cbi-27	175	8	protein	protein	NOUN
cbi-27	175	9	fibers	fiber	NOUN
cbi-27	175	10	that	that	PRON
cbi-27	175	11	surrounds	surround	VERB
cbi-27	175	12	the	the	DET
cbi-27	175	13	nucleolus	nucleolus	NOUN
cbi-27	175	14	and	and	CCONJ
cbi-27	175	15	this	this	PRON
cbi-27	175	16	would	would	AUX
cbi-27	175	17	create	create	VERB
cbi-27	175	18	an	an	DET
cbi-27	175	19	additional	additional	ADJ
cbi-27	175	20	(	(	PUNCT
cbi-27	175	21	protective	protective	ADJ
cbi-27	175	22	)	)	PUNCT
cbi-27	175	23	protein	protein	NOUN
cbi-27	175	24	layer	layer	NOUN
cbi-27	175	25	that	that	PRON
cbi-27	175	26	could	could	AUX
cbi-27	175	27	create	create	VERB
cbi-27	175	28	the	the	DET
cbi-27	175	29	environment	environment	NOUN
cbi-27	175	30	for	for	ADP
cbi-27	175	31	additional	additional	ADJ
cbi-27	175	32	processes	process	NOUN
cbi-27	175	33	.	.	PUNCT
cbi-27	176	1	on	on	ADP
cbi-27	176	2	top	top	NOUN
cbi-27	176	3	of	of	ADP
cbi-27	176	4	this	this	DET
cbi-27	176	5	fiber	fiber	NOUN
cbi-27	176	6	scaffold	scaffold	NOUN
cbi-27	176	7	,	,	PUNCT
cbi-27	176	8	the	the	DET
cbi-27	176	9	nuclear	nuclear	ADJ
cbi-27	176	10	lamina	lamina	NOUN
cbi-27	176	11	can	can	AUX
cbi-27	176	12	be	be	AUX
cbi-27	176	13	formed	form	VERB
cbi-27	176	14	as	as	ADP
cbi-27	176	15	a	a	DET
cbi-27	176	16	distinct	distinct	ADJ
cbi-27	176	17	protein	protein	NOUN
cbi-27	176	18	scaffold	scaffold	NOUN
cbi-27	176	19	that	that	PRON
cbi-27	176	20	can	can	AUX
cbi-27	176	21	form	form	VERB
cbi-27	176	22	a	a	DET
cbi-27	176	23	semi	semi	ADJ
cbi-27	176	24	-	-	ADJ
cbi-27	176	25	permeable	permeable	ADJ
cbi-27	176	26	barrier	barrier	NOUN
cbi-27	176	27	resembling	resemble	VERB
cbi-27	176	28	the	the	DET
cbi-27	176	29	current	current	ADJ
cbi-27	176	30	nucleus	nucleus	NOUN
cbi-27	176	31	but	but	CCONJ
cbi-27	176	32	without	without	ADP
cbi-27	176	33	the	the	DET
cbi-27	176	34	nuclear	nuclear	ADJ
cbi-27	176	35	membrane	membrane	NOUN
cbi-27	176	36	.	.	PUNCT
cbi-27	177	1	at	at	ADP
cbi-27	177	2	that	that	DET
cbi-27	177	3	moment	moment	NOUN
cbi-27	177	4	,	,	PUNCT
cbi-27	177	5	a	a	DET
cbi-27	177	6	primitive	primitive	ADJ
cbi-27	177	7	cell	cell	NOUN
cbi-27	177	8	is	be	AUX
cbi-27	177	9	formed	form	VERB
cbi-27	177	10	that	that	SCONJ
cbi-27	177	11	consists	consist	VERB
cbi-27	177	12	of	of	ADP
cbi-27	177	13	a	a	DET
cbi-27	177	14	replicating	replicate	VERB
cbi-27	177	15	chromosome	chromosome	NOUN
cbi-27	177	16	embedded	embed	VERB
cbi-27	177	17	in	in	ADP
cbi-27	177	18	permeable	permeable	ADJ
cbi-27	177	19	,	,	PUNCT
cbi-27	177	20	multiple	multiple	ADJ
cbi-27	177	21	layers	layer	NOUN
cbi-27	177	22	of	of	ADP
cbi-27	177	23	protein	protein	NOUN
cbi-27	177	24	scaffolding	scaffolding	NOUN
cbi-27	177	25	.	.	PUNCT
cbi-27	178	1	since	since	SCONJ
cbi-27	178	2	the	the	DET
cbi-27	178	3	proteins	protein	NOUN
cbi-27	178	4	for	for	ADP
cbi-27	178	5	the	the	DET
cbi-27	178	6	nuclear	nuclear	ADJ
cbi-27	178	7	lamina	lamina	NOUN
cbi-27	178	8	originate	originate	VERB
cbi-27	178	9	from	from	ADP
cbi-27	178	10	dna	dna	NOUN
cbi-27	178	11	genes	gene	NOUN
cbi-27	178	12	,	,	PUNCT
cbi-27	178	13	the	the	DET
cbi-27	178	14	early	early	ADJ
cbi-27	178	15	genome	genome	NOUN
cbi-27	178	16	can	can	AUX
cbi-27	178	17	develop	develop	VERB
cbi-27	178	18	its	its	PRON
cbi-27	178	19	own	own	ADJ
cbi-27	178	20	environment	environment	NOUN
cbi-27	178	21	.	.	PUNCT
cbi-27	179	1	5.3	5.3	NUM
cbi-27	179	2	self	self	NOUN
cbi-27	179	3	-	-	PUNCT
cbi-27	179	4	assembly	assembly	NOUN
cbi-27	179	5	of	of	ADP
cbi-27	179	6	lipids	lipid	NOUN
cbi-27	179	7	on	on	ADP
cbi-27	179	8	protein	protein	NOUN
cbi-27	179	9	scaffold	scaffold	NOUN
cbi-27	179	10	lipids	lipid	NOUN
cbi-27	179	11	play	play	VERB
cbi-27	179	12	an	an	DET
cbi-27	179	13	important	important	ADJ
cbi-27	179	14	role	role	NOUN
cbi-27	179	15	in	in	ADP
cbi-27	179	16	the	the	DET
cbi-27	179	17	biology	biology	NOUN
cbi-27	179	18	of	of	ADP
cbi-27	179	19	the	the	DET
cbi-27	179	20	cell	cell	NOUN
cbi-27	179	21	and	and	CCONJ
cbi-27	179	22	many	many	ADJ
cbi-27	179	23	chemical	chemical	ADJ
cbi-27	179	24	reactions	reaction	NOUN
cbi-27	179	25	take	take	VERB
cbi-27	179	26	place	place	NOUN
cbi-27	179	27	with	with	ADP
cbi-27	179	28	the	the	DET
cbi-27	179	29	help	help	NOUN
cbi-27	179	30	of	of	ADP
cbi-27	179	31	lipids	lipid	NOUN
cbi-27	179	32	.	.	PUNCT
cbi-27	180	1	also	also	ADV
cbi-27	180	2	,	,	PUNCT
cbi-27	180	3	lipids	lipid	NOUN
cbi-27	180	4	have	have	VERB
cbi-27	180	5	the	the	DET
cbi-27	180	6	ability	ability	NOUN
cbi-27	180	7	to	to	PART
cbi-27	180	8	form	form	VERB
cbi-27	180	9	vesicles	vesicle	NOUN
cbi-27	180	10	and	and	CCONJ
cbi-27	180	11	membranes	membrane	NOUN
cbi-27	180	12	to	to	PART
cbi-27	180	13	form	form	VERB
cbi-27	180	14	a	a	DET
cbi-27	180	15	specialized	specialized	ADJ
cbi-27	180	16	microenvironment	microenvironment	NOUN
cbi-27	180	17	.	.	PUNCT
cbi-27	181	1	the	the	DET
cbi-27	181	2	evolution	evolution	NOUN
cbi-27	181	3	of	of	ADP
cbi-27	181	4	lipid	lipid	NOUN
cbi-27	181	5	generating	generate	VERB
cbi-27	181	6	proteins	protein	NOUN
cbi-27	181	7	could	could	AUX
cbi-27	181	8	lead	lead	VERB
cbi-27	181	9	to	to	ADP
cbi-27	181	10	microvesicles	microvesicle	NOUN
cbi-27	181	11	that	that	PRON
cbi-27	181	12	could	could	AUX
cbi-27	181	13	facilitate	facilitate	VERB
cbi-27	181	14	replication	replication	NOUN
cbi-27	181	15	and	and	CCONJ
cbi-27	181	16	these	these	DET
cbi-27	181	17	vesicles	vesicle	NOUN
cbi-27	181	18	could	could	AUX
cbi-27	181	19	be	be	AUX
cbi-27	181	20	associated	associate	VERB
cbi-27	181	21	with	with	ADP
cbi-27	181	22	the	the	DET
cbi-27	181	23	nucleolus	nucleolus	NOUN
cbi-27	181	24	and	and	CCONJ
cbi-27	181	25	the	the	DET
cbi-27	181	26	nuclear	nuclear	ADJ
cbi-27	181	27	matrix	matrix	NOUN
cbi-27	181	28	.	.	PUNCT
cbi-27	182	1	at	at	ADP
cbi-27	182	2	a	a	DET
cbi-27	182	3	high	high	ADJ
cbi-27	182	4	enough	enough	ADJ
cbi-27	182	5	density	density	NOUN
cbi-27	182	6	and	and	CCONJ
cbi-27	182	7	by	by	ADP
cbi-27	182	8	the	the	DET
cbi-27	182	9	expression	expression	NOUN
cbi-27	182	10	of	of	ADP
cbi-27	182	11	certain	certain	ADJ
cbi-27	182	12	nuclear	nuclear	ADJ
cbi-27	182	13	lamina	lamina	NOUN
cbi-27	182	14	proteins	protein	NOUN
cbi-27	182	15	,	,	PUNCT
cbi-27	182	16	these	these	DET
cbi-27	182	17	vesicles	vesicle	NOUN
cbi-27	182	18	could	could	AUX
cbi-27	182	19	fuse	fuse	VERB
cbi-27	182	20	on	on	ADP
cbi-27	182	21	top	top	NOUN
cbi-27	182	22	of	of	ADP
cbi-27	182	23	the	the	DET
cbi-27	182	24	nuclear	nuclear	ADJ
cbi-27	182	25	lamina	lamina	NOUN
cbi-27	182	26	and	and	CCONJ
cbi-27	182	27	form	form	VERB
cbi-27	182	28	the	the	DET
cbi-27	182	29	first	first	ADJ
cbi-27	182	30	nuclear	nuclear	ADJ
cbi-27	182	31	membrane	membrane	NOUN
cbi-27	182	32	.	.	PUNCT
cbi-27	183	1	the	the	DET
cbi-27	183	2	evolutionary	evolutionary	ADJ
cbi-27	183	3	steps	step	NOUN
cbi-27	183	4	in	in	ADP
cbi-27	183	5	the	the	DET
cbi-27	183	6	formation	formation	NOUN
cbi-27	183	7	of	of	ADP
cbi-27	183	8	the	the	DET
cbi-27	183	9	nucleus	nucleus	NOUN
cbi-27	183	10	can	can	AUX
cbi-27	183	11	be	be	AUX
cbi-27	183	12	seen	see	VERB
cbi-27	183	13	at	at	ADP
cbi-27	183	14	cell	cell	NOUN
cbi-27	183	15	division	division	NOUN
cbi-27	183	16	,	,	PUNCT
cbi-27	183	17	where	where	SCONJ
cbi-27	183	18	the	the	DET
cbi-27	183	19	nuclear	nuclear	ADJ
cbi-27	183	20	membrane	membrane	NOUN
cbi-27	183	21	is	be	AUX
cbi-27	183	22	dissolved	dissolve	VERB
cbi-27	183	23	into	into	ADP
cbi-27	183	24	vesicles	vesicle	NOUN
cbi-27	183	25	and	and	CCONJ
cbi-27	183	26	reforms	reform	NOUN
cbi-27	183	27	after	after	ADP
cbi-27	183	28	the	the	DET
cbi-27	183	29	cell	cell	NOUN
cbi-27	183	30	division	division	NOUN
cbi-27	183	31	.	.	PUNCT
cbi-27	184	1	thus	thus	ADV
cbi-27	184	2	,	,	PUNCT
cbi-27	184	3	by	by	ADP
cbi-27	184	4	expressing	express	VERB
cbi-27	184	5	a	a	DET
cbi-27	184	6	set	set	NOUN
cbi-27	184	7	of	of	ADP
cbi-27	184	8	proteins	protein	NOUN
cbi-27	184	9	,	,	PUNCT
cbi-27	184	10	a	a	DET
cbi-27	184	11	self	self	NOUN
cbi-27	184	12	-	-	PUNCT
cbi-27	184	13	assembly	assembly	NOUN
cbi-27	184	14	of	of	ADP
cbi-27	184	15	lipids	lipid	NOUN
cbi-27	184	16	on	on	ADP
cbi-27	184	17	the	the	DET
cbi-27	184	18	nuclear	nuclear	ADJ
cbi-27	184	19	lamina	lamina	NOUN
cbi-27	184	20	the	the	DET
cbi-27	184	21	nucleus	nucleus	NOUN
cbi-27	184	22	could	could	AUX
cbi-27	184	23	have	have	AUX
cbi-27	184	24	formed	form	VERB
cbi-27	184	25	as	as	ADP
cbi-27	184	26	the	the	DET
cbi-27	184	27	first	first	ADJ
cbi-27	184	28	membrane	membrane	NOUN
cbi-27	184	29	-	-	PUNCT
cbi-27	184	30	surrounded	surround	VERB
cbi-27	184	31	cell	cell	NOUN
cbi-27	184	32	.	.	PUNCT
cbi-27	185	1	volume	volume	NOUN
cbi-27	185	2	1	1	NUM
cbi-27	185	3	,	,	PUNCT
cbi-27	185	4	issue	issue	NOUN
cbi-27	185	5	1	1	NUM
cbi-27	185	6	6	6	NUM
cbi-27	185	7	.	.	PUNCT
cbi-27	186	1	the	the	DET
cbi-27	186	2	eukaryotic	eukaryotic	ADJ
cbi-27	186	3	cell	cell	NOUN
cbi-27	186	4	11	11	NUM
cbi-27	186	5	5.4	5.4	NUM
cbi-27	186	6	the	the	DET
cbi-27	186	7	nucleus	nucleus	NOUN
cbi-27	186	8	as	as	ADP
cbi-27	186	9	an	an	DET
cbi-27	186	10	independent	independent	ADJ
cbi-27	186	11	organism	organism	NOUN
cbi-27	186	12	the	the	DET
cbi-27	186	13	first	first	ADJ
cbi-27	186	14	’	'	PUNCT
cbi-27	186	15	cell	cell	NOUN
cbi-27	186	16	’	'	PUNCT
cbi-27	186	17	with	with	ADP
cbi-27	186	18	a	a	DET
cbi-27	186	19	membrane	membrane	NOUN
cbi-27	186	20	in	in	ADP
cbi-27	186	21	evolution	evolution	NOUN
cbi-27	186	22	would	would	AUX
cbi-27	186	23	in	in	ADP
cbi-27	186	24	our	our	PRON
cbi-27	186	25	model	model	NOUN
cbi-27	186	26	consist	consist	NOUN
cbi-27	186	27	of	of	ADP
cbi-27	186	28	the	the	DET
cbi-27	186	29	nucleus	nucleus	NOUN
cbi-27	186	30	and	and	CCONJ
cbi-27	186	31	would	would	AUX
cbi-27	186	32	precede	precede	VERB
cbi-27	186	33	the	the	DET
cbi-27	186	34	eukaryotic	eukaryotic	ADJ
cbi-27	186	35	cell	cell	NOUN
cbi-27	186	36	with	with	ADP
cbi-27	186	37	a	a	DET
cbi-27	186	38	plasma	plasma	NOUN
cbi-27	186	39	membrane	membrane	NOUN
cbi-27	186	40	.	.	PUNCT
cbi-27	187	1	it	it	PRON
cbi-27	187	2	would	would	AUX
cbi-27	187	3	be	be	AUX
cbi-27	187	4	an	an	DET
cbi-27	187	5	independent	independent	ADJ
cbi-27	187	6	unit	unit	NOUN
cbi-27	187	7	that	that	PRON
cbi-27	187	8	contained	contain	VERB
cbi-27	187	9	all	all	DET
cbi-27	187	10	the	the	DET
cbi-27	187	11	information	information	NOUN
cbi-27	187	12	to	to	PART
cbi-27	187	13	replicate	replicate	VERB
cbi-27	187	14	itself	itself	PRON
cbi-27	187	15	.	.	PUNCT
cbi-27	188	1	if	if	SCONJ
cbi-27	188	2	the	the	DET
cbi-27	188	3	dna	dna	NOUN
cbi-27	188	4	is	be	AUX
cbi-27	188	5	replicated	replicate	VERB
cbi-27	188	6	,	,	PUNCT
cbi-27	188	7	this	this	DET
cbi-27	188	8	nucleus	nucleus	NOUN
cbi-27	188	9	could	could	AUX
cbi-27	188	10	physically	physically	ADV
cbi-27	188	11	divide	divide	VERB
cbi-27	188	12	into	into	ADP
cbi-27	188	13	two	two	NUM
cbi-27	188	14	nuclei	nucleus	NOUN
cbi-27	188	15	as	as	SCONJ
cbi-27	188	16	we	we	PRON
cbi-27	188	17	see	see	VERB
cbi-27	188	18	with	with	ADP
cbi-27	188	19	each	each	DET
cbi-27	188	20	mitosis	mitosis	NOUN
cbi-27	188	21	.	.	PUNCT
cbi-27	189	1	in	in	ADP
cbi-27	189	2	this	this	DET
cbi-27	189	3	scenario	scenario	NOUN
cbi-27	189	4	we	we	PRON
cbi-27	189	5	see	see	VERB
cbi-27	189	6	the	the	DET
cbi-27	189	7	nucleus	nucleus	NOUN
cbi-27	189	8	as	as	ADP
cbi-27	189	9	an	an	DET
cbi-27	189	10	independent	independent	ADJ
cbi-27	189	11	unit	unit	NOUN
cbi-27	189	12	that	that	PRON
cbi-27	189	13	can	can	AUX
cbi-27	189	14	replicate	replicate	VERB
cbi-27	189	15	itself	itself	PRON
cbi-27	189	16	into	into	ADP
cbi-27	189	17	to	to	ADP
cbi-27	189	18	other	other	ADJ
cbi-27	189	19	nuclei	nucleus	NOUN
cbi-27	189	20	since	since	SCONJ
cbi-27	189	21	each	each	DET
cbi-27	189	22	genome	genome	NOUN
cbi-27	189	23	can	can	AUX
cbi-27	189	24	generate	generate	VERB
cbi-27	189	25	its	its	PRON
cbi-27	189	26	own	own	ADJ
cbi-27	189	27	proteins	protein	NOUN
cbi-27	189	28	for	for	ADP
cbi-27	189	29	the	the	DET
cbi-27	189	30	nuclear	nuclear	ADJ
cbi-27	189	31	matrix	matrix	NOUN
cbi-27	189	32	and	and	CCONJ
cbi-27	189	33	formation	formation	NOUN
cbi-27	189	34	of	of	ADP
cbi-27	189	35	a	a	DET
cbi-27	189	36	nuclear	nuclear	ADJ
cbi-27	189	37	membrane	membrane	NOUN
cbi-27	189	38	.	.	PUNCT
cbi-27	190	1	the	the	DET
cbi-27	190	2	independence	independence	NOUN
cbi-27	190	3	of	of	ADP
cbi-27	190	4	the	the	DET
cbi-27	190	5	nucleus	nucleus	NOUN
cbi-27	190	6	as	as	ADP
cbi-27	190	7	an	an	DET
cbi-27	190	8	independently	independently	ADV
cbi-27	190	9	replicating	replicate	VERB
cbi-27	190	10	unit	unit	NOUN
cbi-27	190	11	is	be	AUX
cbi-27	190	12	seen	see	VERB
cbi-27	190	13	in	in	ADP
cbi-27	190	14	the	the	DET
cbi-27	190	15	development	development	NOUN
cbi-27	190	16	of	of	ADP
cbi-27	190	17	drosophila	drosophila	PROPN
cbi-27	190	18	.	.	PUNCT
cbi-27	191	1	here	here	ADV
cbi-27	191	2	,	,	PUNCT
cbi-27	191	3	the	the	DET
cbi-27	191	4	nucleus	nucleus	NOUN
cbi-27	191	5	of	of	ADP
cbi-27	191	6	the	the	DET
cbi-27	191	7	fertilized	fertilize	VERB
cbi-27	191	8	egg	egg	NOUN
cbi-27	191	9	divides	divide	VERB
cbi-27	191	10	numerous	numerous	ADJ
cbi-27	191	11	times	time	NOUN
cbi-27	191	12	within	within	ADP
cbi-27	191	13	the	the	DET
cbi-27	191	14	cytoplasm	cytoplasm	NOUN
cbi-27	191	15	,	,	PUNCT
cbi-27	191	16	generating	generate	VERB
cbi-27	191	17	a	a	DET
cbi-27	191	18	large	large	ADJ
cbi-27	191	19	number	number	NOUN
cbi-27	191	20	of	of	ADP
cbi-27	191	21	nuclei	nucleus	NOUN
cbi-27	191	22	within	within	ADP
cbi-27	191	23	a	a	DET
cbi-27	191	24	single	single	ADJ
cbi-27	191	25	cytoplasm	cytoplasm	NOUN
cbi-27	191	26	.	.	PUNCT
cbi-27	192	1	later	later	ADV
cbi-27	192	2	,	,	PUNCT
cbi-27	192	3	these	these	DET
cbi-27	192	4	nuclei	nucleus	NOUN
cbi-27	192	5	organize	organize	VERB
cbi-27	192	6	themselves	themselves	PRON
cbi-27	192	7	,	,	PUNCT
cbi-27	192	8	mainly	mainly	ADV
cbi-27	192	9	guided	guide	VERB
cbi-27	192	10	by	by	ADP
cbi-27	192	11	an	an	DET
cbi-27	192	12	extranuclear	extranuclear	NOUN
cbi-27	192	13	network	network	NOUN
cbi-27	192	14	into	into	ADP
cbi-27	192	15	mononuclear	mononuclear	ADJ
cbi-27	192	16	cells	cell	NOUN
cbi-27	192	17	.	.	PUNCT
cbi-27	193	1	the	the	DET
cbi-27	193	2	nucleus	nucleus	NOUN
cbi-27	193	3	can	can	AUX
cbi-27	193	4	then	then	ADV
cbi-27	193	5	be	be	AUX
cbi-27	193	6	seen	see	VERB
cbi-27	193	7	as	as	ADP
cbi-27	193	8	replicating	replicate	VERB
cbi-27	193	9	itself	itself	PRON
cbi-27	193	10	into	into	ADP
cbi-27	193	11	two	two	NUM
cbi-27	193	12	within	within	ADP
cbi-27	193	13	the	the	DET
cbi-27	193	14	cytoplasm	cytoplasm	NOUN
cbi-27	193	15	and	and	CCONJ
cbi-27	193	16	in	in	ADP
cbi-27	193	17	principle	principle	NOUN
cbi-27	193	18	independent	independent	ADJ
cbi-27	193	19	from	from	ADP
cbi-27	193	20	the	the	DET
cbi-27	193	21	division	division	NOUN
cbi-27	193	22	of	of	ADP
cbi-27	193	23	the	the	DET
cbi-27	193	24	eukaryotic	eukaryotic	ADJ
cbi-27	193	25	cell	cell	NOUN
cbi-27	193	26	itself	itself	PRON
cbi-27	193	27	.	.	PUNCT
cbi-27	194	1	5.5	5.5	NUM
cbi-27	194	2	the	the	DET
cbi-27	194	3	nucleus	nucleus	NOUN
cbi-27	194	4	as	as	ADP
cbi-27	194	5	a	a	DET
cbi-27	194	6	legacy	legacy	NOUN
cbi-27	194	7	system	system	NOUN
cbi-27	194	8	the	the	DET
cbi-27	194	9	scenario	scenario	NOUN
cbi-27	194	10	presented	present	VERB
cbi-27	194	11	here	here	ADV
cbi-27	194	12	indicates	indicate	VERB
cbi-27	194	13	that	that	SCONJ
cbi-27	194	14	the	the	DET
cbi-27	194	15	nucleus	nucleus	NOUN
cbi-27	194	16	evolved	evolve	VERB
cbi-27	194	17	inside	inside	NOUN
cbi-27	194	18	-	-	PUNCT
cbi-27	194	19	out	out	NOUN
cbi-27	194	20	and	and	CCONJ
cbi-27	194	21	started	start	VERB
cbi-27	194	22	with	with	ADP
cbi-27	194	23	the	the	DET
cbi-27	194	24	nucleolus	nucleolus	NOUN
cbi-27	194	25	upon	upon	SCONJ
cbi-27	194	26	which	which	PRON
cbi-27	194	27	literary	literary	ADJ
cbi-27	194	28	new	new	ADJ
cbi-27	194	29	layers	layer	NOUN
cbi-27	194	30	of	of	ADP
cbi-27	194	31	functions	function	NOUN
cbi-27	194	32	were	be	AUX
cbi-27	194	33	added	add	VERB
cbi-27	194	34	that	that	SCONJ
cbi-27	194	35	resulting	result	VERB
cbi-27	194	36	in	in	ADP
cbi-27	194	37	the	the	DET
cbi-27	194	38	nucleus	nucleus	NOUN
cbi-27	194	39	as	as	ADP
cbi-27	194	40	an	an	DET
cbi-27	194	41	independent	independent	ADJ
cbi-27	194	42	unit	unit	NOUN
cbi-27	194	43	.	.	PUNCT
cbi-27	195	1	we	we	PRON
cbi-27	195	2	then	then	ADV
cbi-27	195	3	see	see	VERB
cbi-27	195	4	various	various	ADJ
cbi-27	195	5	structural	structural	ADJ
cbi-27	195	6	and	and	CCONJ
cbi-27	195	7	functional	functional	ADJ
cbi-27	195	8	components	component	NOUN
cbi-27	195	9	in	in	ADP
cbi-27	195	10	the	the	DET
cbi-27	195	11	nucleus	nucleus	NOUN
cbi-27	195	12	that	that	PRON
cbi-27	195	13	are	be	AUX
cbi-27	195	14	functionally	functionally	ADV
cbi-27	195	15	and	and	CCONJ
cbi-27	195	16	structurally	structurally	ADV
cbi-27	195	17	dependent	dependent	ADJ
cbi-27	195	18	on	on	ADP
cbi-27	195	19	each	each	DET
cbi-27	195	20	other	other	ADJ
cbi-27	195	21	.	.	PUNCT
cbi-27	196	1	next	next	ADV
cbi-27	196	2	to	to	ADP
cbi-27	196	3	the	the	DET
cbi-27	196	4	distinct	distinct	ADJ
cbi-27	196	5	entity	entity	NOUN
cbi-27	196	6	of	of	ADP
cbi-27	196	7	the	the	DET
cbi-27	196	8	nucleolus	nucleolus	NOUN
cbi-27	196	9	,	,	PUNCT
cbi-27	196	10	we	we	PRON
cbi-27	196	11	discern	discern	VERB
cbi-27	196	12	the	the	DET
cbi-27	196	13	larger	large	ADJ
cbi-27	196	14	nuclear	nuclear	ADJ
cbi-27	196	15	matrix	matrix	NOUN
cbi-27	196	16	and	and	CCONJ
cbi-27	196	17	finally	finally	ADV
cbi-27	196	18	the	the	DET
cbi-27	196	19	nuclear	nuclear	ADJ
cbi-27	196	20	lamina	lamina	NOUN
cbi-27	196	21	as	as	ADP
cbi-27	196	22	a	a	DET
cbi-27	196	23	protein	protein	NOUN
cbi-27	196	24	sheath	sheath	NOUN
cbi-27	196	25	that	that	PRON
cbi-27	196	26	encapsulates	encapsulate	VERB
cbi-27	196	27	the	the	DET
cbi-27	196	28	chromosomes	chromosome	NOUN
cbi-27	196	29	and	and	CCONJ
cbi-27	196	30	ribosomes	ribosome	NOUN
cbi-27	196	31	.	.	PUNCT
cbi-27	197	1	during	during	ADP
cbi-27	197	2	the	the	DET
cbi-27	197	3	evolution	evolution	NOUN
cbi-27	197	4	to	to	ADP
cbi-27	197	5	the	the	DET
cbi-27	197	6	eukaryotic	eukaryotic	ADJ
cbi-27	197	7	cell	cell	NOUN
cbi-27	197	8	,	,	PUNCT
cbi-27	197	9	the	the	DET
cbi-27	197	10	nucleus	nucleus	NOUN
cbi-27	197	11	and	and	CCONJ
cbi-27	197	12	all	all	DET
cbi-27	197	13	previous	previous	ADJ
cbi-27	197	14	processes	process	NOUN
cbi-27	197	15	layers	layer	NOUN
cbi-27	197	16	remain	remain	VERB
cbi-27	197	17	intact	intact	ADJ
cbi-27	197	18	.	.	PUNCT
cbi-27	198	1	the	the	DET
cbi-27	198	2	entire	entire	ADJ
cbi-27	198	3	nucleus	nucleus	NOUN
cbi-27	198	4	of	of	ADP
cbi-27	198	5	eukaryotes	eukaryote	NOUN
cbi-27	198	6	can	can	AUX
cbi-27	198	7	therefore	therefore	ADV
cbi-27	198	8	be	be	AUX
cbi-27	198	9	considered	consider	VERB
cbi-27	198	10	a	a	DET
cbi-27	198	11	legacy	legacy	NOUN
cbi-27	198	12	system	system	NOUN
cbi-27	198	13	that	that	PRON
cbi-27	198	14	functionally	functionally	ADV
cbi-27	198	15	stays	stay	VERB
cbi-27	198	16	intact	intact	ADJ
cbi-27	198	17	during	during	ADP
cbi-27	198	18	the	the	DET
cbi-27	198	19	entire	entire	ADJ
cbi-27	198	20	path	path	NOUN
cbi-27	198	21	of	of	ADP
cbi-27	198	22	eukaryote	eukaryote	NOUN
cbi-27	198	23	evolution	evolution	NOUN
cbi-27	198	24	.	.	PUNCT
cbi-27	199	1	6	6	NUM
cbi-27	199	2	the	the	DET
cbi-27	199	3	eukaryotic	eukaryotic	ADJ
cbi-27	199	4	cell	cell	NOUN
cbi-27	199	5	we	we	PRON
cbi-27	199	6	saw	see	VERB
cbi-27	199	7	that	that	SCONJ
cbi-27	199	8	we	we	PRON
cbi-27	199	9	can	can	AUX
cbi-27	199	10	stepwise	stepwise	VERB
cbi-27	199	11	build	build	VERB
cbi-27	199	12	up	up	ADP
cbi-27	199	13	a	a	DET
cbi-27	199	14	simple	simple	ADJ
cbi-27	199	15	proto	proto	NOUN
cbi-27	199	16	-	-	PUNCT
cbi-27	199	17	cell	cell	NOUN
cbi-27	199	18	that	that	PRON
cbi-27	199	19	evolved	evolve	VERB
cbi-27	199	20	into	into	ADP
cbi-27	199	21	a	a	DET
cbi-27	199	22	self	self	NOUN
cbi-27	199	23	-	-	PUNCT
cbi-27	199	24	contained	contain	VERB
cbi-27	199	25	replicating	replicate	VERB
cbi-27	199	26	unit	unit	NOUN
cbi-27	199	27	:	:	PUNCT
cbi-27	199	28	the	the	DET
cbi-27	199	29	nucleus	nucleus	NOUN
cbi-27	199	30	as	as	ADP
cbi-27	199	31	the	the	DET
cbi-27	199	32	first	first	ADJ
cbi-27	199	33	real	real	ADJ
cbi-27	199	34	cellular	cellular	ADJ
cbi-27	199	35	life	life	NOUN
cbi-27	199	36	.	.	PUNCT
cbi-27	200	1	the	the	DET
cbi-27	200	2	next	next	ADJ
cbi-27	200	3	major	major	ADJ
cbi-27	200	4	step	step	NOUN
cbi-27	200	5	in	in	ADP
cbi-27	200	6	the	the	DET
cbi-27	200	7	evolution	evolution	NOUN
cbi-27	200	8	of	of	ADP
cbi-27	200	9	life	life	NOUN
cbi-27	200	10	was	be	AUX
cbi-27	200	11	the	the	DET
cbi-27	200	12	evolution	evolution	NOUN
cbi-27	200	13	of	of	ADP
cbi-27	200	14	the	the	DET
cbi-27	200	15	plasma	plasma	NOUN
cbi-27	200	16	membrane	membrane	NOUN
cbi-27	200	17	that	that	PRON
cbi-27	200	18	surrounds	surround	VERB
cbi-27	200	19	the	the	DET
cbi-27	200	20	nucleus	nucleus	NOUN
cbi-27	200	21	.	.	PUNCT
cbi-27	201	1	from	from	ADP
cbi-27	201	2	the	the	DET
cbi-27	201	3	distinct	distinct	ADJ
cbi-27	201	4	functional	functional	ADJ
cbi-27	201	5	components	component	NOUN
cbi-27	201	6	we	we	PRON
cbi-27	201	7	can	can	AUX
cbi-27	201	8	deduce	deduce	VERB
cbi-27	201	9	the	the	DET
cbi-27	201	10	evolutionary	evolutionary	ADJ
cbi-27	201	11	events	event	NOUN
cbi-27	201	12	to	to	PART
cbi-27	201	13	generate	generate	VERB
cbi-27	201	14	the	the	DET
cbi-27	201	15	main	main	ADJ
cbi-27	201	16	components	component	NOUN
cbi-27	201	17	of	of	ADP
cbi-27	201	18	the	the	DET
cbi-27	201	19	eukaryotic	eukaryotic	ADJ
cbi-27	201	20	cell	cell	NOUN
cbi-27	201	21	.	.	PUNCT
cbi-27	202	1	6.1	6.1	NUM
cbi-27	202	2	formation	formation	NOUN
cbi-27	202	3	of	of	ADP
cbi-27	202	4	endoplasmic	endoplasmic	ADJ
cbi-27	202	5	reticulum	reticulum	NOUN
cbi-27	202	6	(	(	PUNCT
cbi-27	202	7	er	er	INTJ
cbi-27	202	8	)	)	PUNCT
cbi-27	202	9	the	the	DET
cbi-27	202	10	er	er	INTJ
cbi-27	202	11	membrane	membrane	NOUN
cbi-27	202	12	is	be	AUX
cbi-27	202	13	contiguous	contiguous	ADJ
cbi-27	202	14	with	with	ADP
cbi-27	202	15	the	the	DET
cbi-27	202	16	nuclear	nuclear	ADJ
cbi-27	202	17	membrane	membrane	NOUN
cbi-27	202	18	which	which	PRON
cbi-27	202	19	means	mean	VERB
cbi-27	202	20	that	that	SCONJ
cbi-27	202	21	it	it	PRON
cbi-27	202	22	shares	share	VERB
cbi-27	202	23	its	its	PRON
cbi-27	202	24	membrane	membrane	NOUN
cbi-27	202	25	and	and	CCONJ
cbi-27	202	26	their	their	PRON
cbi-27	202	27	membranes	membrane	NOUN
cbi-27	202	28	can	can	AUX
cbi-27	202	29	be	be	AUX
cbi-27	202	30	seen	see	VERB
cbi-27	202	31	as	as	ADP
cbi-27	202	32	a	a	DET
cbi-27	202	33	single	single	ADJ
cbi-27	202	34	continuum	continuum	NOUN
cbi-27	202	35	.	.	PUNCT
cbi-27	203	1	in	in	ADP
cbi-27	203	2	evolution	evolution	NOUN
cbi-27	203	3	the	the	DET
cbi-27	203	4	transition	transition	NOUN
cbi-27	203	5	to	to	ADP
cbi-27	203	6	the	the	DET
cbi-27	203	7	er	er	INTJ
cbi-27	203	8	could	could	AUX
cbi-27	203	9	be	be	AUX
cbi-27	203	10	made	make	VERB
cbi-27	203	11	when	when	SCONJ
cbi-27	203	12	the	the	DET
cbi-27	203	13	nuclear	nuclear	ADJ
cbi-27	203	14	membrane	membrane	NOUN
cbi-27	203	15	started	start	VERB
cbi-27	203	16	’	'	PUNCT
cbi-27	203	17	blebbing	blebbe	VERB
cbi-27	203	18	’	'	PUNCT
cbi-27	203	19	into	into	ADP
cbi-27	203	20	membrane	membrane	NOUN
cbi-27	203	21	lamellae	lamellae	NOUN
cbi-27	203	22	into	into	ADP
cbi-27	203	23	a	a	DET
cbi-27	203	24	special	special	ADJ
cbi-27	203	25	compartment	compartment	NOUN
cbi-27	203	26	which	which	PRON
cbi-27	203	27	became	become	VERB
cbi-27	203	28	later	later	ADV
cbi-27	203	29	the	the	DET
cbi-27	203	30	er	er	INTJ
cbi-27	203	31	.	.	PUNCT
cbi-27	203	32	membrane	membrane	NOUN
cbi-27	203	33	blebbing	blebbe	VERB
cbi-27	203	34	can	can	AUX
cbi-27	203	35	occur	occur	VERB
cbi-27	203	36	by	by	ADP
cbi-27	203	37	the	the	DET
cbi-27	203	38	expression	expression	NOUN
cbi-27	203	39	of	of	ADP
cbi-27	203	40	membrane	membrane	NOUN
cbi-27	203	41	proteins	protein	NOUN
cbi-27	203	42	and	and	CCONJ
cbi-27	203	43	therefore	therefore	ADV
cbi-27	203	44	,	,	PUNCT
cbi-27	203	45	this	this	DET
cbi-27	203	46	step	step	NOUN
cbi-27	203	47	could	could	AUX
cbi-27	203	48	thus	thus	ADV
cbi-27	203	49	be	be	AUX
cbi-27	203	50	evoked	evoke	VERB
cbi-27	203	51	by	by	ADP
cbi-27	203	52	the	the	DET
cbi-27	203	53	novel	novel	ADJ
cbi-27	203	54	expression	expression	NOUN
cbi-27	203	55	of	of	ADP
cbi-27	203	56	a	a	DET
cbi-27	203	57	single	single	ADJ
cbi-27	203	58	new	new	ADJ
cbi-27	203	59	protein	protein	NOUN
cbi-27	203	60	in	in	ADP
cbi-27	203	61	evolution	evolution	NOUN
cbi-27	203	62	.	.	PUNCT
cbi-27	204	1	the	the	DET
cbi-27	204	2	generation	generation	NOUN
cbi-27	204	3	of	of	ADP
cbi-27	204	4	a	a	DET
cbi-27	204	5	separate	separate	ADJ
cbi-27	204	6	lipid	lipid	NOUN
cbi-27	204	7	environment	environment	NOUN
cbi-27	204	8	outside	outside	ADP
cbi-27	204	9	of	of	ADP
cbi-27	204	10	the	the	DET
cbi-27	204	11	nucleus	nucleus	NOUN
cbi-27	204	12	would	would	AUX
cbi-27	204	13	allow	allow	VERB
cbi-27	204	14	many	many	ADJ
cbi-27	204	15	new	new	ADJ
cbi-27	204	16	functions	function	NOUN
cbi-27	204	17	to	to	PART
cbi-27	204	18	evolve	evolve	VERB
cbi-27	204	19	.	.	PUNCT
cbi-27	205	1	for	for	ADP
cbi-27	205	2	instance	instance	NOUN
cbi-27	205	3	,	,	PUNCT
cbi-27	205	4	protein	protein	NOUN
cbi-27	205	5	translation	translation	NOUN
cbi-27	205	6	could	could	AUX
cbi-27	205	7	be	be	AUX
cbi-27	205	8	done	do	VERB
cbi-27	205	9	more	more	ADV
cbi-27	205	10	efficiently	efficiently	ADV
cbi-27	205	11	at	at	ADP
cbi-27	205	12	the	the	DET
cbi-27	205	13	er	er	INTJ
cbi-27	205	14	.	.	PUNCT
cbi-27	206	1	the	the	DET
cbi-27	206	2	disassembly	disassembly	NOUN
cbi-27	206	3	of	of	ADP
cbi-27	206	4	ribosome	ribosome	ADJ
cbi-27	206	5	subunits	subunit	NOUN
cbi-27	206	6	in	in	ADP
cbi-27	206	7	the	the	DET
cbi-27	206	8	nucleus	nucleus	NOUN
cbi-27	206	9	and	and	CCONJ
cbi-27	206	10	the	the	DET
cbi-27	206	11	subsequent	subsequent	ADJ
cbi-27	206	12	transport	transport	NOUN
cbi-27	206	13	of	of	ADP
cbi-27	206	14	these	these	DET
cbi-27	206	15	units	unit	NOUN
cbi-27	206	16	to	to	PART
cbi-27	206	17	reassemble	reassemble	VERB
cbi-27	206	18	at	at	ADP
cbi-27	206	19	the	the	DET
cbi-27	206	20	er	er	INTJ
cbi-27	206	21	illustrate	illustrate	VERB
cbi-27	206	22	this	this	DET
cbi-27	206	23	process	process	NOUN
cbi-27	206	24	.	.	PUNCT
cbi-27	207	1	6.2	6.2	NUM
cbi-27	207	2	the	the	DET
cbi-27	207	3	formation	formation	NOUN
cbi-27	207	4	of	of	ADP
cbi-27	207	5	a	a	DET
cbi-27	207	6	cytoskeleton	cytoskeleton	NOUN
cbi-27	207	7	the	the	DET
cbi-27	207	8	eukaryotic	eukaryotic	ADJ
cbi-27	207	9	cell	cell	NOUN
cbi-27	207	10	consists	consist	VERB
cbi-27	207	11	of	of	ADP
cbi-27	207	12	the	the	DET
cbi-27	207	13	nucleus	nucleus	NOUN
cbi-27	207	14	surrounded	surround	VERB
cbi-27	207	15	by	by	ADP
cbi-27	207	16	the	the	DET
cbi-27	207	17	cytoskeleton	cytoskeleton	NOUN
cbi-27	207	18	which	which	PRON
cbi-27	207	19	provides	provide	VERB
cbi-27	207	20	structure	structure	NOUN
cbi-27	207	21	but	but	CCONJ
cbi-27	207	22	also	also	ADV
cbi-27	207	23	a	a	DET
cbi-27	207	24	microenvironment	microenvironment	NOUN
cbi-27	207	25	for	for	ADP
cbi-27	207	26	cellular	cellular	ADJ
cbi-27	207	27	processes	process	NOUN
cbi-27	207	28	.	.	PUNCT
cbi-27	208	1	a	a	DET
cbi-27	208	2	first	first	ADJ
cbi-27	208	3	step	step	NOUN
cbi-27	208	4	to	to	ADP
cbi-27	208	5	such	such	DET
cbi-27	208	6	an	an	DET
cbi-27	208	7	extranuclear	extranuclear	NOUN
cbi-27	208	8	environment	environment	NOUN
cbi-27	208	9	could	could	AUX
cbi-27	208	10	be	be	AUX
cbi-27	208	11	the	the	DET
cbi-27	208	12	extension	extension	NOUN
cbi-27	208	13	of	of	ADP
cbi-27	208	14	protein	protein	NOUN
cbi-27	208	15	fibers	fiber	NOUN
cbi-27	208	16	from	from	ADP
cbi-27	208	17	within	within	ADP
cbi-27	208	18	the	the	DET
cbi-27	208	19	nucleus	nucleus	NOUN
cbi-27	208	20	trough	trough	NOUN
cbi-27	208	21	the	the	DET
cbi-27	208	22	nuclear	nuclear	ADJ
cbi-27	208	23	pores	pore	NOUN
cbi-27	208	24	.	.	PUNCT
cbi-27	209	1	this	this	PRON
cbi-27	209	2	would	would	AUX
cbi-27	209	3	give	give	VERB
cbi-27	209	4	the	the	DET
cbi-27	209	5	nucleus	nucleus	NOUN
cbi-27	209	6	already	already	ADV
cbi-27	209	7	protection	protection	NOUN
cbi-27	209	8	and	and	CCONJ
cbi-27	209	9	anchor	anchor	NOUN
cbi-27	209	10	points	point	NOUN
cbi-27	209	11	for	for	ADP
cbi-27	209	12	specific	specific	ADJ
cbi-27	209	13	energy	energy	NOUN
cbi-27	209	14	-	-	PUNCT
cbi-27	209	15	rich	rich	ADJ
cbi-27	209	16	environments	environment	NOUN
cbi-27	209	17	.	.	PUNCT
cbi-27	210	1	later	later	ADV
cbi-27	210	2	in	in	ADP
cbi-27	210	3	evolution	evolution	NOUN
cbi-27	210	4	,	,	PUNCT
cbi-27	210	5	when	when	SCONJ
cbi-27	210	6	extranuclear	extranuclear	PROPN
cbi-27	210	7	(	(	PUNCT
cbi-27	210	8	cytoplasmic	cytoplasmic	ADJ
cbi-27	210	9	)	)	PUNCT
cbi-27	210	10	translation	translation	NOUN
cbi-27	210	11	at	at	ADP
cbi-27	210	12	the	the	PRON
cbi-27	210	13	er	er	INTJ
cbi-27	210	14	could	could	AUX
cbi-27	210	15	take	take	VERB
cbi-27	210	16	place	place	NOUN
cbi-27	210	17	,	,	PUNCT
cbi-27	210	18	the	the	DET
cbi-27	210	19	cytoskeleton	cytoskeleton	NOUN
cbi-27	210	20	could	could	AUX
cbi-27	210	21	evolve	evolve	VERB
cbi-27	210	22	into	into	ADP
cbi-27	210	23	a	a	DET
cbi-27	210	24	more	more	ADV
cbi-27	210	25	complex	complex	ADJ
cbi-27	210	26	protein	protein	NOUN
cbi-27	210	27	scaffold	scaffold	NOUN
cbi-27	210	28	.	.	PUNCT
cbi-27	211	1	the	the	DET
cbi-27	211	2	nucleus	nucleus	NOUN
cbi-27	211	3	would	would	AUX
cbi-27	211	4	be	be	AUX
cbi-27	211	5	suspended	suspend	VERB
cbi-27	211	6	in	in	ADP
cbi-27	211	7	its	its	PRON
cbi-27	211	8	own	own	ADJ
cbi-27	211	9	cytoskeleton	cytoskeleton	NOUN
cbi-27	211	10	that	that	SCONJ
cbi-27	211	11	it	it	PRON
cbi-27	211	12	generated	generate	VERB
cbi-27	211	13	from	from	ADP
cbi-27	211	14	its	its	PRON
cbi-27	211	15	genome	genome	NOUN
cbi-27	211	16	.	.	PUNCT
cbi-27	212	1	each	each	DET
cbi-27	212	2	nucleus	nucleus	NOUN
cbi-27	212	3	would	would	AUX
cbi-27	212	4	then	then	ADV
cbi-27	212	5	have	have	VERB
cbi-27	212	6	its	its	PRON
cbi-27	212	7	cytoskeletal	cytoskeletal	ADJ
cbi-27	212	8	coat	coat	NOUN
cbi-27	212	9	which	which	PRON
cbi-27	212	10	would	would	AUX
cbi-27	212	11	define	define	VERB
cbi-27	212	12	the	the	DET
cbi-27	212	13	boundaries	boundary	NOUN
cbi-27	212	14	of	of	ADP
cbi-27	212	15	the	the	DET
cbi-27	212	16	cell	cell	NOUN
cbi-27	212	17	,	,	PUNCT
cbi-27	212	18	similar	similar	ADJ
cbi-27	212	19	to	to	ADP
cbi-27	212	20	the	the	DET
cbi-27	212	21	drosophila	drosophila	NOUN
cbi-27	212	22	cells	cell	NOUN
cbi-27	212	23	in	in	ADP
cbi-27	212	24	the	the	DET
cbi-27	212	25	syncytial	syncytial	ADJ
cbi-27	212	26	blastoderm	blastoderm	NOUN
cbi-27	212	27	.	.	PUNCT
cbi-27	213	1	6.3	6.3	NUM
cbi-27	213	2	formation	formation	NOUN
cbi-27	213	3	of	of	ADP
cbi-27	213	4	the	the	DET
cbi-27	213	5	plasma	plasma	NOUN
cbi-27	213	6	membrane	membrane	NOUN
cbi-27	213	7	starting	start	VERB
cbi-27	213	8	from	from	ADP
cbi-27	213	9	a	a	DET
cbi-27	213	10	nucleus	nucleus	NOUN
cbi-27	213	11	with	with	ADP
cbi-27	213	12	an	an	DET
cbi-27	213	13	extracellular	extracellular	ADJ
cbi-27	213	14	matrix	matrix	NOUN
cbi-27	213	15	and	and	CCONJ
cbi-27	213	16	an	an	DET
cbi-27	213	17	er	er	INTJ
cbi-27	213	18	,	,	PUNCT
cbi-27	213	19	the	the	DET
cbi-27	213	20	last	last	ADJ
cbi-27	213	21	step	step	NOUN
cbi-27	213	22	in	in	ADP
cbi-27	213	23	the	the	DET
cbi-27	213	24	evolution	evolution	NOUN
cbi-27	213	25	of	of	ADP
cbi-27	213	26	the	the	DET
cbi-27	213	27	eukaryotic	eukaryotic	ADJ
cbi-27	213	28	cell	cell	NOUN
cbi-27	213	29	could	could	AUX
cbi-27	213	30	be	be	AUX
cbi-27	213	31	the	the	DET
cbi-27	213	32	formation	formation	NOUN
cbi-27	213	33	of	of	ADP
cbi-27	213	34	a	a	DET
cbi-27	213	35	plasma	plasma	NOUN
cbi-27	213	36	membrane	membrane	NOUN
cbi-27	213	37	on	on	ADP
cbi-27	213	38	top	top	NOUN
cbi-27	213	39	of	of	ADP
cbi-27	213	40	the	the	DET
cbi-27	213	41	cytoskeleton	cytoskeleton	NOUN
cbi-27	213	42	.	.	PUNCT
cbi-27	214	1	we	we	PRON
cbi-27	214	2	see	see	VERB
cbi-27	214	3	the	the	DET
cbi-27	214	4	dependency	dependency	NOUN
cbi-27	214	5	between	between	ADP
cbi-27	214	6	the	the	DET
cbi-27	214	7	er	er	INTJ
cbi-27	214	8	and	and	CCONJ
cbi-27	214	9	the	the	DET
cbi-27	214	10	plasma	plasma	NOUN
cbi-27	214	11	membrane	membrane	NOUN
cbi-27	214	12	as	as	ADP
cbi-27	214	13	the	the	DET
cbi-27	214	14	er	er	INTJ
cbi-27	214	15	and	and	CCONJ
cbi-27	214	16	the	the	DET
cbi-27	214	17	endomembrane	endomembrane	NOUN
cbi-27	214	18	system	system	NOUN
cbi-27	214	19	feed	feed	VERB
cbi-27	214	20	directly	directly	ADV
cbi-27	214	21	into	into	ADP
cbi-27	214	22	the	the	DET
cbi-27	214	23	plasma	plasma	NOUN
cbi-27	214	24	membrane	membrane	NOUN
cbi-27	214	25	.	.	PUNCT
cbi-27	215	1	within	within	ADP
cbi-27	215	2	the	the	DET
cbi-27	215	3	eukaryotic	eukaryotic	ADJ
cbi-27	215	4	cell	cell	NOUN
cbi-27	215	5	,	,	PUNCT
cbi-27	215	6	vesicles	vesicle	NOUN
cbi-27	215	7	bud	bud	VERB
cbi-27	215	8	off	off	ADP
cbi-27	215	9	from	from	ADP
cbi-27	215	10	the	the	DET
cbi-27	215	11	er	er	INTJ
cbi-27	215	12	/	/	SYM
cbi-27	215	13	golgi	golgi	NOUN
cbi-27	215	14	and	and	CCONJ
cbi-27	215	15	fuse	fuse	NOUN
cbi-27	215	16	with	with	ADP
cbi-27	215	17	the	the	DET
cbi-27	215	18	plasma	plasma	NOUN
cbi-27	215	19	membrane	membrane	NOUN
cbi-27	215	20	to	to	PART
cbi-27	215	21	increase	increase	VERB
cbi-27	215	22	the	the	DET
cbi-27	215	23	surface	surface	NOUN
cbi-27	215	24	of	of	ADP
cbi-27	215	25	the	the	DET
cbi-27	215	26	cell	cell	NOUN
cbi-27	215	27	.	.	PUNCT
cbi-27	216	1	a	a	DET
cbi-27	216	2	plasma	plasma	NOUN
cbi-27	216	3	membrane	membrane	NOUN
cbi-27	216	4	could	could	AUX
cbi-27	216	5	have	have	AUX
cbi-27	216	6	formed	form	VERB
cbi-27	216	7	in	in	ADP
cbi-27	216	8	evolution	evolution	NOUN
cbi-27	216	9	in	in	ADP
cbi-27	216	10	two	two	NUM
cbi-27	216	11	steps	step	NOUN
cbi-27	216	12	.	.	PUNCT
cbi-27	217	1	first	first	ADJ
cbi-27	217	2	vesicles	vesicle	NOUN
cbi-27	217	3	started	start	VERB
cbi-27	217	4	budding	bud	VERB
cbi-27	217	5	of	of	ADP
cbi-27	217	6	the	the	DET
cbi-27	217	7	er	er	INTJ
cbi-27	217	8	by	by	ADP
cbi-27	217	9	expression	expression	NOUN
cbi-27	217	10	of	of	ADP
cbi-27	217	11	new	new	ADJ
cbi-27	217	12	proteins	protein	NOUN
cbi-27	217	13	that	that	PRON
cbi-27	217	14	facilitated	facilitate	VERB
cbi-27	217	15	budding	budding	NOUN
cbi-27	217	16	.	.	PUNCT
cbi-27	218	1	second	second	ADJ
cbi-27	218	2	,	,	PUNCT
cbi-27	218	3	vesicles	vesicle	NOUN
cbi-27	218	4	could	could	AUX
cbi-27	218	5	start	start	VERB
cbi-27	218	6	fusing	fuse	VERB
cbi-27	218	7	onto	onto	ADP
cbi-27	218	8	the	the	DET
cbi-27	218	9	cytoskeleton	cytoskeleton	NOUN
cbi-27	218	10	to	to	PART
cbi-27	218	11	form	form	VERB
cbi-27	218	12	12	12	NUM
cbi-27	218	13	a	a	DET
cbi-27	218	14	proposed	propose	VERB
cbi-27	218	15	framework	framework	NOUN
cbi-27	218	16	for	for	ADP
cbi-27	218	17	cellular	cellular	ADJ
cbi-27	218	18	evolution	evolution	NOUN
cbi-27	218	19	a	a	DET
cbi-27	218	20	plasma	plasma	NOUN
cbi-27	218	21	membrane	membrane	NOUN
cbi-27	218	22	,	,	PUNCT
cbi-27	218	23	also	also	ADV
cbi-27	218	24	facilitated	facilitate	VERB
cbi-27	218	25	by	by	ADP
cbi-27	218	26	the	the	DET
cbi-27	218	27	expression	expression	NOUN
cbi-27	218	28	of	of	ADP
cbi-27	218	29	novel	novel	ADJ
cbi-27	218	30	proteins	protein	NOUN
cbi-27	218	31	.	.	PUNCT
cbi-27	219	1	6.4	6.4	NUM
cbi-27	219	2	conclusion	conclusion	NOUN
cbi-27	219	3	the	the	DET
cbi-27	219	4	design	design	NOUN
cbi-27	219	5	framework	framework	NOUN
cbi-27	219	6	and	and	CCONJ
cbi-27	219	7	the	the	DET
cbi-27	219	8	resulting	result	VERB
cbi-27	219	9	new	new	ADJ
cbi-27	219	10	insight	insight	NOUN
cbi-27	219	11	in	in	ADP
cbi-27	219	12	the	the	DET
cbi-27	219	13	path	path	NOUN
cbi-27	219	14	of	of	ADP
cbi-27	219	15	evolution	evolution	NOUN
cbi-27	219	16	can	can	AUX
cbi-27	219	17	therefore	therefore	ADV
cbi-27	219	18	present	present	VERB
cbi-27	219	19	a	a	DET
cbi-27	219	20	new	new	ADJ
cbi-27	219	21	set	set	NOUN
cbi-27	219	22	of	of	ADP
cbi-27	219	23	paradigms	paradigm	NOUN
cbi-27	219	24	for	for	ADP
cbi-27	219	25	new	new	ADJ
cbi-27	219	26	evolutionary	evolutionary	ADJ
cbi-27	219	27	theories	theory	NOUN
cbi-27	219	28	.	.	PUNCT
cbi-27	220	1	the	the	DET
cbi-27	220	2	first	first	ADJ
cbi-27	220	3	one	one	NUM
cbi-27	220	4	is	be	AUX
cbi-27	220	5	that	that	SCONJ
cbi-27	220	6	evolution	evolution	NOUN
cbi-27	220	7	can	can	AUX
cbi-27	220	8	be	be	AUX
cbi-27	220	9	modeled	model	VERB
cbi-27	220	10	on	on	ADP
cbi-27	220	11	a	a	DET
cbi-27	220	12	design	design	NOUN
cbi-27	220	13	framework	framework	NOUN
cbi-27	220	14	which	which	PRON
cbi-27	220	15	enables	enable	VERB
cbi-27	220	16	us	we	PRON
cbi-27	220	17	to	to	PART
cbi-27	220	18	deduce	deduce	VERB
cbi-27	220	19	evolutionary	evolutionary	ADJ
cbi-27	220	20	events	event	NOUN
cbi-27	220	21	.	.	PUNCT
cbi-27	221	1	the	the	DET
cbi-27	221	2	second	second	ADJ
cbi-27	221	3	is	be	AUX
cbi-27	221	4	that	that	SCONJ
cbi-27	221	5	life	life	NOUN
cbi-27	221	6	evolved	evolve	VERB
cbi-27	221	7	inside	inside	NOUN
cbi-27	221	8	-	-	PUNCT
cbi-27	221	9	out	out	NOUN
cbi-27	221	10	and	and	CCONJ
cbi-27	221	11	started	start	VERB
cbi-27	221	12	by	by	ADP
cbi-27	221	13	the	the	DET
cbi-27	221	14	stepwise	stepwise	ADJ
cbi-27	221	15	formation	formation	NOUN
cbi-27	221	16	of	of	ADP
cbi-27	221	17	the	the	DET
cbi-27	221	18	nucleus	nucleus	NOUN
cbi-27	221	19	and	and	CCONJ
cbi-27	221	20	was	be	AUX
cbi-27	221	21	followed	follow	VERB
cbi-27	221	22	by	by	ADP
cbi-27	221	23	the	the	DET
cbi-27	221	24	formation	formation	NOUN
cbi-27	221	25	of	of	ADP
cbi-27	221	26	the	the	DET
cbi-27	221	27	er	er	INTJ
cbi-27	221	28	,	,	PUNCT
cbi-27	221	29	the	the	DET
cbi-27	221	30	cytoskeleton	cytoskeleton	PROPN
cbi-27	221	31	and	and	CCONJ
cbi-27	221	32	the	the	DET
cbi-27	221	33	plasma	plasma	NOUN
cbi-27	221	34	membrane	membrane	NOUN
cbi-27	221	35	.	.	PUNCT