id	sid	tid	token	lemma	pos
concept-1708	1	1	microsoft	microsoft	PROPN
concept-1708	1	2	word	word	PROPN
concept-1708	1	3	*	*	PUNCT
concept-1708	1	4	hoban	hoban	PROPN
concept-1708	1	5	mathematical	mathematical	ADJ
concept-1708	1	6	sciences.docx	sciences.docx	PROPN
concept-1708	1	7	  	  	SPACE
concept-1708	1	8	[	[	X
concept-1708	1	9	concept	concept	NOUN
concept-1708	1	10	,	,	PUNCT
concept-1708	1	11	vol	vol	NOUN
concept-1708	1	12	.	.	PUNCT
concept-1708	2	1	xxxvii	xxxvii	PROPN
concept-1708	2	2	(	(	PUNCT
concept-1708	2	3	2014	2014	NUM
concept-1708	2	4	)	)	PUNCT
concept-1708	2	5	]	]	PUNCT
concept-1708	3	1	a	a	DET
concept-1708	3	2	review	review	NOUN
concept-1708	3	3	of	of	ADP
concept-1708	3	4	mathematical	mathematical	ADJ
concept-1708	3	5	models	model	NOUN
concept-1708	3	6	of	of	ADP
concept-1708	3	7	metastatic	metastatic	ADJ
concept-1708	3	8	cancer	cancer	NOUN
concept-1708	3	9	katrina	katrina	PROPN
concept-1708	3	10	hoban	hoban	PROPN
concept-1708	3	11	mathematical	mathematical	PROPN
concept-1708	3	12	sciences	sciences	PROPN
concept-1708	3	13	  	  	SPACE
concept-1708	3	14	i.	i.	NOUN
concept-1708	3	15	introduction	introduction	NOUN
concept-1708	3	16	:	:	PUNCT
concept-1708	3	17	the	the	DET
concept-1708	3	18	metastatic	metastatic	ADJ
concept-1708	3	19	process	process	NOUN
concept-1708	3	20	of	of	ADP
concept-1708	3	21	cancer	cancer	NOUN
concept-1708	3	22	when	when	SCONJ
concept-1708	3	23	cancer	cancer	NOUN
concept-1708	3	24	cells	cell	NOUN
concept-1708	3	25	detach	detach	VERB
concept-1708	3	26	from	from	ADP
concept-1708	3	27	an	an	DET
concept-1708	3	28	original	original	ADJ
concept-1708	3	29	tumor	tumor	NOUN
concept-1708	3	30	site	site	NOUN
concept-1708	3	31	to	to	PART
concept-1708	3	32	spread	spread	VERB
concept-1708	3	33	throughout	throughout	ADP
concept-1708	3	34	the	the	DET
concept-1708	3	35	body	body	NOUN
concept-1708	3	36	,	,	PUNCT
concept-1708	3	37	it	it	PRON
concept-1708	3	38	is	be	AUX
concept-1708	3	39	called	call	VERB
concept-1708	3	40	metastasis	metastasis	NOUN
concept-1708	3	41	.	.	PUNCT
concept-1708	4	1	metastatic	metastatic	ADJ
concept-1708	4	2	cancer	cancer	NOUN
concept-1708	4	3	cells	cell	NOUN
concept-1708	4	4	can	can	AUX
concept-1708	4	5	move	move	VERB
concept-1708	4	6	either	either	ADV
concept-1708	4	7	by	by	ADP
concept-1708	4	8	direct	direct	ADJ
concept-1708	4	9	contact	contact	NOUN
concept-1708	4	10	with	with	ADP
concept-1708	4	11	new	new	ADJ
concept-1708	4	12	organ	organ	NOUN
concept-1708	4	13	sites	site	NOUN
concept-1708	4	14	or	or	CCONJ
concept-1708	4	15	through	through	ADP
concept-1708	4	16	the	the	DET
concept-1708	4	17	blood	blood	NOUN
concept-1708	4	18	or	or	CCONJ
concept-1708	4	19	lymphatic	lymphatic	ADJ
concept-1708	4	20	systems	system	NOUN
concept-1708	4	21	of	of	ADP
concept-1708	4	22	the	the	DET
concept-1708	4	23	body	body	NOUN
concept-1708	4	24	,	,	PUNCT
concept-1708	4	25	but	but	CCONJ
concept-1708	4	26	there	there	PRON
concept-1708	4	27	is	be	VERB
concept-1708	4	28	a	a	DET
concept-1708	4	29	generally	generally	ADV
concept-1708	4	30	accepted	accept	VERB
concept-1708	4	31	path	path	NOUN
concept-1708	4	32	process	process	NOUN
concept-1708	4	33	for	for	ADP
concept-1708	4	34	this	this	DET
concept-1708	4	35	spread	spread	NOUN
concept-1708	4	36	(	(	PUNCT
concept-1708	4	37	1	1	NUM
concept-1708	4	38	)	)	PUNCT
concept-1708	4	39	.	.	PUNCT
concept-1708	5	1	first	first	ADV
concept-1708	5	2	,	,	PUNCT
concept-1708	5	3	the	the	DET
concept-1708	5	4	cells	cell	NOUN
concept-1708	5	5	invade	invade	VERB
concept-1708	5	6	healthy	healthy	ADJ
concept-1708	5	7	tissue	tissue	NOUN
concept-1708	5	8	close	close	ADV
concept-1708	5	9	to	to	ADP
concept-1708	5	10	the	the	DET
concept-1708	5	11	original	original	ADJ
concept-1708	5	12	cancerous	cancerous	ADJ
concept-1708	5	13	site	site	NOUN
concept-1708	5	14	,	,	PUNCT
concept-1708	5	15	most	most	ADV
concept-1708	5	16	likely	likely	ADJ
concept-1708	5	17	by	by	ADP
concept-1708	5	18	lymph	lymph	NOUN
concept-1708	5	19	or	or	CCONJ
concept-1708	5	20	blood	blood	NOUN
concept-1708	5	21	vessels	vessel	NOUN
concept-1708	5	22	—	—	PUNCT
concept-1708	5	23	this	this	PRON
concept-1708	5	24	is	be	AUX
concept-1708	5	25	called	call	VERB
concept-1708	5	26	intravasation	intravasation	NOUN
concept-1708	5	27	(	(	PUNCT
concept-1708	5	28	3	3	NUM
concept-1708	5	29	)	)	PUNCT
concept-1708	5	30	.	.	PUNCT
concept-1708	6	1	once	once	SCONJ
concept-1708	6	2	they	they	PRON
concept-1708	6	3	are	be	AUX
concept-1708	6	4	in	in	ADP
concept-1708	6	5	one	one	NUM
concept-1708	6	6	of	of	ADP
concept-1708	6	7	these	these	DET
concept-1708	6	8	circulatory	circulatory	ADJ
concept-1708	6	9	systems	system	NOUN
concept-1708	6	10	,	,	PUNCT
concept-1708	6	11	the	the	DET
concept-1708	6	12	cancer	cancer	NOUN
concept-1708	6	13	cells	cell	NOUN
concept-1708	6	14	travel	travel	VERB
concept-1708	6	15	to	to	ADP
concept-1708	6	16	distant	distant	ADJ
concept-1708	6	17	parts	part	NOUN
concept-1708	6	18	of	of	ADP
concept-1708	6	19	the	the	DET
concept-1708	6	20	body	body	NOUN
concept-1708	6	21	.	.	PUNCT
concept-1708	7	1	they	they	PRON
concept-1708	7	2	stop	stop	VERB
concept-1708	7	3	in	in	ADP
concept-1708	7	4	small	small	ADJ
concept-1708	7	5	blood	blood	NOUN
concept-1708	7	6	vessels	vessel	NOUN
concept-1708	7	7	called	call	VERB
concept-1708	7	8	capillaries	capillary	NOUN
concept-1708	7	9	where	where	SCONJ
concept-1708	7	10	they	they	PRON
concept-1708	7	11	traverse	traverse	VERB
concept-1708	7	12	through	through	ADP
concept-1708	7	13	the	the	DET
concept-1708	7	14	vessel	vessel	NOUN
concept-1708	7	15	walls	wall	NOUN
concept-1708	7	16	and	and	CCONJ
concept-1708	7	17	into	into	ADP
concept-1708	7	18	surrounding	surround	VERB
concept-1708	7	19	tissues	tissue	NOUN
concept-1708	7	20	through	through	ADP
concept-1708	7	21	a	a	DET
concept-1708	7	22	process	process	NOUN
concept-1708	7	23	called	call	VERB
concept-1708	7	24	extravasation	extravasation	NOUN
concept-1708	7	25	.	.	PUNCT
concept-1708	8	1	the	the	DET
concept-1708	8	2	cells	cell	NOUN
concept-1708	8	3	reproduce	reproduce	VERB
concept-1708	8	4	to	to	PART
concept-1708	8	5	develop	develop	VERB
concept-1708	8	6	small	small	ADJ
concept-1708	8	7	micrometastatic	micrometastatic	ADJ
concept-1708	8	8	tumors	tumor	NOUN
concept-1708	8	9	.	.	PUNCT
concept-1708	9	1	if	if	SCONJ
concept-1708	9	2	the	the	DET
concept-1708	9	3	small	small	ADJ
concept-1708	9	4	tumor	tumor	NOUN
concept-1708	9	5	is	be	AUX
concept-1708	9	6	able	able	ADJ
concept-1708	9	7	to	to	PART
concept-1708	9	8	stimulate	stimulate	VERB
concept-1708	9	9	growth	growth	NOUN
concept-1708	9	10	of	of	ADP
concept-1708	9	11	new	new	ADJ
concept-1708	9	12	blood	blood	NOUN
concept-1708	9	13	vessels	vessel	NOUN
concept-1708	9	14	to	to	PART
concept-1708	9	15	attain	attain	VERB
concept-1708	9	16	a	a	DET
concept-1708	9	17	blood	blood	NOUN
concept-1708	9	18	supply	supply	NOUN
concept-1708	9	19	,	,	PUNCT
concept-1708	9	20	the	the	DET
concept-1708	9	21	tumor	tumor	NOUN
concept-1708	9	22	can	can	AUX
concept-1708	9	23	grow	grow	VERB
concept-1708	9	24	larger	large	ADJ
concept-1708	9	25	into	into	ADP
concept-1708	9	26	a	a	DET
concept-1708	9	27	full	full	ADV
concept-1708	9	28	-	-	PUNCT
concept-1708	9	29	fledged	fledged	ADJ
concept-1708	9	30	metastatic	metastatic	ADJ
concept-1708	9	31	tumor	tumor	NOUN
concept-1708	9	32	.	.	PUNCT
concept-1708	10	1	thriving	thrive	VERB
concept-1708	10	2	metastases	metastasis	NOUN
concept-1708	10	3	are	be	AUX
concept-1708	10	4	also	also	ADV
concept-1708	10	5	contingent	contingent	ADJ
concept-1708	10	6	on	on	ADP
concept-1708	10	7	the	the	DET
concept-1708	10	8	properties	property	NOUN
concept-1708	10	9	of	of	ADP
concept-1708	10	10	the	the	DET
concept-1708	10	11	noncancerous	noncancerous	ADJ
concept-1708	10	12	cells	cell	NOUN
concept-1708	10	13	,	,	PUNCT
concept-1708	10	14	such	such	ADJ
concept-1708	10	15	as	as	ADP
concept-1708	10	16	immune	immune	ADJ
concept-1708	10	17	system	system	NOUN
concept-1708	10	18	cells	cell	NOUN
concept-1708	10	19	at	at	ADP
concept-1708	10	20	the	the	DET
concept-1708	10	21	original	original	ADJ
concept-1708	10	22	and	and	CCONJ
concept-1708	10	23	new	new	ADJ
concept-1708	10	24	sites	site	NOUN
concept-1708	10	25	as	as	ADV
concept-1708	10	26	well	well	ADV
concept-1708	10	27	as	as	ADP
concept-1708	10	28	ones	one	NOUN
concept-1708	10	29	they	they	PRON
concept-1708	10	30	encounter	encounter	VERB
concept-1708	10	31	on	on	ADP
concept-1708	10	32	their	their	PRON
concept-1708	10	33	journey	journey	NOUN
concept-1708	10	34	through	through	ADP
concept-1708	10	35	the	the	DET
concept-1708	10	36	body	body	NOUN
concept-1708	10	37	(	(	PUNCT
concept-1708	10	38	1	1	NUM
concept-1708	10	39	)	)	PUNCT
concept-1708	10	40	.	.	PUNCT
concept-1708	11	1	while	while	SCONJ
concept-1708	11	2	it	it	PRON
concept-1708	11	3	is	be	AUX
concept-1708	11	4	believed	believe	VERB
concept-1708	11	5	that	that	SCONJ
concept-1708	11	6	all	all	DET
concept-1708	11	7	types	type	NOUN
concept-1708	11	8	of	of	ADP
concept-1708	11	9	cancer	cancer	NOUN
concept-1708	11	10	are	be	AUX
concept-1708	11	11	able	able	ADJ
concept-1708	11	12	to	to	PART
concept-1708	11	13	spread	spread	VERB
concept-1708	11	14	metastatically	metastatically	ADV
concept-1708	11	15	,	,	PUNCT
concept-1708	11	16	not	not	PART
concept-1708	11	17	every	every	DET
concept-1708	11	18	singular	singular	ADJ
concept-1708	11	19	cancer	cancer	NOUN
concept-1708	11	20	cell	cell	NOUN
concept-1708	11	21	has	have	VERB
concept-1708	11	22	the	the	DET
concept-1708	11	23	ability	ability	NOUN
concept-1708	11	24	to	to	PART
concept-1708	11	25	metastasize	metastasize	VERB
concept-1708	11	26	on	on	ADP
concept-1708	11	27	its	its	PRON
concept-1708	11	28	own	own	ADJ
concept-1708	11	29	.	.	PUNCT
concept-1708	12	1	the	the	DET
concept-1708	12	2	most	most	ADV
concept-1708	12	3	common	common	ADJ
concept-1708	12	4	sites	site	NOUN
concept-1708	12	5	of	of	ADP
concept-1708	12	6	metastasis	metastasis	NOUN
concept-1708	12	7	for	for	ADP
concept-1708	12	8	all	all	DET
concept-1708	12	9	cancers	cancer	NOUN
concept-1708	12	10	(	(	PUNCT
concept-1708	12	11	excluding	exclude	VERB
concept-1708	12	12	lymph	lymph	NOUN
concept-1708	12	13	nodes	node	NOUN
concept-1708	12	14	since	since	SCONJ
concept-1708	12	15	they	they	PRON
concept-1708	12	16	are	be	AUX
concept-1708	12	17	a	a	DET
concept-1708	12	18	method	method	NOUN
concept-1708	12	19	of	of	ADP
concept-1708	12	20	transit	transit	NOUN
concept-1708	12	21	for	for	ADP
concept-1708	12	22	the	the	DET
concept-1708	12	23	cells	cell	NOUN
concept-1708	12	24	)	)	PUNCT
concept-1708	12	25	are	be	AUX
concept-1708	12	26	the	the	DET
concept-1708	12	27	bone	bone	NOUN
concept-1708	12	28	,	,	PUNCT
concept-1708	12	29	liver	liver	NOUN
concept-1708	12	30	,	,	PUNCT
concept-1708	12	31	and	and	CCONJ
concept-1708	12	32	lungs	lung	NOUN
concept-1708	12	33	(	(	PUNCT
concept-1708	12	34	1	1	NUM
concept-1708	12	35	)	)	PUNCT
concept-1708	12	36	.	.	PUNCT
concept-1708	13	1	the	the	DET
concept-1708	13	2	diagram	diagram	NOUN
concept-1708	13	3	below	below	ADV
concept-1708	13	4	shows	show	VERB
concept-1708	13	5	how	how	SCONJ
concept-1708	13	6	cancer	cancer	NOUN
concept-1708	13	7	will	will	AUX
concept-1708	13	8	spread	spread	VERB
concept-1708	13	9	from	from	ADP
concept-1708	13	10	any	any	DET
concept-1708	13	11	original	original	ADJ
concept-1708	13	12	tumor	tumor	NOUN
concept-1708	13	13	site	site	NOUN
concept-1708	13	14	to	to	ADP
concept-1708	13	15	various	various	ADJ
concept-1708	13	16	metastatic	metastatic	ADJ
concept-1708	13	17	growth	growth	NOUN
concept-1708	13	18	sites	site	NOUN
concept-1708	13	19	in	in	ADP
concept-1708	13	20	the	the	DET
concept-1708	13	21	body	body	NOUN
concept-1708	13	22	.	.	PUNCT
concept-1708	13	23	  	  	SPACE
concept-1708	14	1	an	an	DET
concept-1708	14	2	overview	overview	NOUN
concept-1708	14	3	of	of	ADP
concept-1708	14	4	the	the	DET
concept-1708	14	5	metastatic	metastatic	ADJ
concept-1708	14	6	process	process	NOUN
concept-1708	14	7	(	(	PUNCT
concept-1708	14	8	3	3	X
concept-1708	14	9	)	)	PUNCT
concept-1708	14	10	it	it	PRON
concept-1708	14	11	is	be	AUX
concept-1708	14	12	important	important	ADJ
concept-1708	14	13	to	to	PART
concept-1708	14	14	note	note	VERB
concept-1708	14	15	that	that	SCONJ
concept-1708	14	16	even	even	ADV
concept-1708	14	17	after	after	SCONJ
concept-1708	14	18	the	the	DET
concept-1708	14	19	cancer	cancer	NOUN
concept-1708	14	20	has	have	AUX
concept-1708	14	21	established	establish	VERB
concept-1708	14	22	a	a	DET
concept-1708	14	23	metastatic	metastatic	ADJ
concept-1708	14	24	tumor	tumor	NOUN
concept-1708	14	25	in	in	ADP
concept-1708	14	26	a	a	DET
concept-1708	14	27	new	new	ADJ
concept-1708	14	28	area	area	NOUN
concept-1708	14	29	of	of	ADP
concept-1708	14	30	the	the	DET
concept-1708	14	31	body	body	NOUN
concept-1708	14	32	,	,	PUNCT
concept-1708	14	33	the	the	DET
concept-1708	14	34	cancer	cancer	NOUN
concept-1708	14	35	itself	itself	PRON
concept-1708	14	36	is	be	AUX
concept-1708	14	37	still	still	ADV
concept-1708	14	38	the	the	DET
concept-1708	14	39	original	original	ADJ
concept-1708	14	40	type	type	NOUN
concept-1708	14	41	of	of	ADP
concept-1708	14	42	cancer	cancer	NOUN
concept-1708	14	43	.	.	PUNCT
concept-1708	15	1	for	for	ADP
concept-1708	15	2	example	example	NOUN
concept-1708	15	3	,	,	PUNCT
concept-1708	15	4	if	if	SCONJ
concept-1708	15	5	cancer	cancer	NOUN
concept-1708	15	6	of	of	ADP
concept-1708	15	7	the	the	DET
concept-1708	15	8	lung	lung	NOUN
concept-1708	15	9	grows	grow	VERB
concept-1708	15	10	in	in	ADP
concept-1708	15	11	the	the	DET
concept-1708	15	12	breast	breast	NOUN
concept-1708	15	13	,	,	PUNCT
concept-1708	15	14	the	the	DET
concept-1708	15	15	new	new	ADJ
concept-1708	15	16	tumor	tumor	NOUN
concept-1708	15	17	is	be	AUX
concept-1708	15	18	still	still	ADV
concept-1708	15	19	lung	lung	NOUN
concept-1708	15	20	cancer	cancer	NOUN
concept-1708	15	21	that	that	PRON
concept-1708	15	22	happens	happen	VERB
concept-1708	15	23	to	to	PART
concept-1708	15	24	have	have	AUX
concept-1708	15	25	grown	grow	VERB
concept-1708	15	26	in	in	ADP
concept-1708	15	27	the	the	DET
concept-1708	15	28	breast	breast	NOUN
concept-1708	15	29	.	.	PUNCT
concept-1708	16	1	the	the	DET
concept-1708	16	2	new	new	ADJ
concept-1708	16	3	cancer	cancer	NOUN
concept-1708	16	4	often	often	ADV
concept-1708	16	5	has	have	VERB
concept-1708	16	6	similar	similar	ADJ
concept-1708	16	7	molecular	molecular	ADJ
concept-1708	16	8	features	feature	NOUN
concept-1708	16	9	and	and	CCONJ
concept-1708	16	10	causes	cause	VERB
concept-1708	16	11	the	the	DET
concept-1708	16	12	same	same	ADJ
concept-1708	16	13	protein	protein	NOUN
concept-1708	16	14	and	and	CCONJ
concept-1708	16	15	chromosome	chromosome	NOUN
concept-1708	16	16	changes	change	NOUN
concept-1708	16	17	as	as	ADP
concept-1708	16	18	the	the	DET
concept-1708	16	19	original	original	ADJ
concept-1708	16	20	(	(	PUNCT
concept-1708	16	21	1	1	NUM
concept-1708	16	22	)	)	PUNCT
concept-1708	16	23	.	.	PUNCT
concept-1708	17	1	it	it	PRON
concept-1708	17	2	is	be	AUX
concept-1708	17	3	possible	possible	ADJ
concept-1708	17	4	for	for	SCONJ
concept-1708	17	5	cancer	cancer	NOUN
concept-1708	17	6	to	to	PART
concept-1708	17	7	metastasize	metastasize	VERB
concept-1708	17	8	and	and	CCONJ
concept-1708	17	9	lie	lie	VERB
concept-1708	17	10	dormant	dormant	ADJ
concept-1708	17	11	for	for	ADP
concept-1708	17	12	years	year	NOUN
concept-1708	17	13	or	or	CCONJ
concept-1708	17	14	even	even	ADV
concept-1708	17	15	forever	forever	ADV
concept-1708	17	16	without	without	ADP
concept-1708	17	17	growing	grow	VERB
concept-1708	17	18	enough	enough	ADV
concept-1708	17	19	to	to	PART
concept-1708	17	20	show	show	VERB
concept-1708	17	21	symptoms	symptom	NOUN
concept-1708	17	22	of	of	ADP
concept-1708	17	23	cancer	cancer	NOUN
concept-1708	17	24	at	at	ADP
concept-1708	17	25	the	the	DET
concept-1708	17	26	new	new	ADJ
concept-1708	17	27	site	site	NOUN
concept-1708	17	28	.	.	PUNCT
concept-1708	18	1	since	since	SCONJ
concept-1708	18	2	all	all	DET
concept-1708	18	3	types	type	NOUN
concept-1708	18	4	of	of	ADP
concept-1708	18	5	cancer	cancer	NOUN
concept-1708	18	6	are	be	AUX
concept-1708	18	7	susceptible	susceptible	ADJ
concept-1708	18	8	to	to	ADP
concept-1708	18	9	metastasis	metastasis	NOUN
concept-1708	18	10	,	,	PUNCT
concept-1708	18	11	experts	expert	NOUN
concept-1708	18	12	have	have	AUX
concept-1708	18	13	been	be	AUX
concept-1708	18	14	working	work	VERB
concept-1708	18	15	for	for	ADP
concept-1708	18	16	decades	decade	NOUN
concept-1708	18	17	to	to	PART
concept-1708	18	18	develop	develop	VERB
concept-1708	18	19	mathematical	mathematical	ADJ
concept-1708	18	20	models	model	NOUN
concept-1708	18	21	to	to	PART
concept-1708	18	22	show	show	VERB
concept-1708	18	23	the	the	DET
concept-1708	18	24	likelihood	likelihood	NOUN
concept-1708	18	25	of	of	ADP
concept-1708	18	26	metastasis	metastasis	NOUN
concept-1708	18	27	in	in	ADP
concept-1708	18	28	different	different	ADJ
concept-1708	18	29	locations	location	NOUN
concept-1708	18	30	of	of	ADP
concept-1708	18	31	the	the	DET
concept-1708	18	32	body	body	NOUN
concept-1708	18	33	for	for	ADP
concept-1708	18	34	all	all	DET
concept-1708	18	35	types	type	NOUN
concept-1708	18	36	of	of	ADP
concept-1708	18	37	cancer	cancer	NOUN
concept-1708	18	38	.	.	PUNCT
concept-1708	19	1	creating	create	VERB
concept-1708	19	2	a	a	DET
concept-1708	19	3	general	general	ADJ
concept-1708	19	4	model	model	NOUN
concept-1708	19	5	of	of	ADP
concept-1708	19	6	metastasis	metastasis	NOUN
concept-1708	19	7	has	have	AUX
concept-1708	19	8	proven	prove	VERB
concept-1708	19	9	to	to	PART
concept-1708	19	10	be	be	AUX
concept-1708	19	11	very	very	ADV
concept-1708	19	12	difficult	difficult	ADJ
concept-1708	19	13	because	because	SCONJ
concept-1708	19	14	cancer	cancer	NOUN
concept-1708	19	15	is	be	AUX
concept-1708	19	16	a	a	DET
concept-1708	19	17	multifaceted	multifaceted	ADJ
concept-1708	19	18	process	process	NOUN
concept-1708	19	19	dependent	dependent	ADJ
concept-1708	19	20	upon	upon	SCONJ
concept-1708	19	21	a	a	DET
concept-1708	19	22	variety	variety	NOUN
concept-1708	19	23	of	of	ADP
concept-1708	19	24	cellular	cellular	ADJ
concept-1708	19	25	and	and	CCONJ
concept-1708	19	26	micro	micro	ADJ
concept-1708	19	27	-	-	ADJ
concept-1708	19	28	environmental	environmental	ADJ
concept-1708	19	29	parameters	parameter	NOUN
concept-1708	19	30	(	(	PUNCT
concept-1708	19	31	11	11	NUM
concept-1708	19	32	)	)	PUNCT
concept-1708	19	33	.	.	PUNCT
concept-1708	20	1	cellular	cellular	ADJ
concept-1708	20	2	parameters	parameter	NOUN
concept-1708	20	3	include	include	VERB
concept-1708	20	4	“	"	PUNCT
concept-1708	20	5	altered	altered	ADJ
concept-1708	20	6	rates	rate	NOUN
concept-1708	20	7	of	of	ADP
concept-1708	20	8	cell	cell	NOUN
concept-1708	20	9	proliferation	proliferation	NOUN
concept-1708	20	10	,	,	PUNCT
concept-1708	20	11	apoptosis	apoptosis	NOUN
concept-1708	20	12	[	[	X
concept-1708	20	13	programmed	programmed	ADJ
concept-1708	20	14	cell	cell	NOUN
concept-1708	20	15	death	death	NOUN
concept-1708	20	16	(	(	PUNCT
concept-1708	20	17	15	15	NUM
concept-1708	20	18	)	)	PUNCT
concept-1708	20	19	]	]	PUNCT
concept-1708	20	20	,	,	PUNCT
concept-1708	20	21	migration	migration	NOUN
concept-1708	20	22	,	,	PUNCT
concept-1708	20	23	adhesion	adhesion	NOUN
concept-1708	20	24	,	,	PUNCT
concept-1708	20	25	metabolism	metabolism	NOUN
concept-1708	20	26	and	and	CCONJ
concept-1708	20	27	mutation	mutation	NOUN
concept-1708	20	28	”	"	PUNCT
concept-1708	20	29	(	(	PUNCT
concept-1708	20	30	11	11	NUM
concept-1708	20	31	)	)	PUNCT
concept-1708	20	32	.	.	PUNCT
concept-1708	21	1	microenvironmental	microenvironmental	ADJ
concept-1708	21	2	constraints	constraint	NOUN
concept-1708	21	3	consist	consist	VERB
concept-1708	21	4	of	of	ADP
concept-1708	21	5	“	"	PUNCT
concept-1708	21	6	extracellular	extracellular	ADJ
concept-1708	21	7	matrix	matrix	NOUN
concept-1708	21	8	composition	composition	NOUN
concept-1708	21	9	,	,	PUNCT
concept-1708	21	10	  	  	SPACE
concept-1708	21	11	angiogenesis	angiogenesis	NOUN
concept-1708	22	1	[	[	X
concept-1708	22	2	development	development	NOUN
concept-1708	22	3	of	of	ADP
concept-1708	22	4	new	new	ADJ
concept-1708	22	5	blood	blood	NOUN
concept-1708	22	6	vessels	vessel	NOUN
concept-1708	22	7	(	(	PUNCT
concept-1708	22	8	15	15	NUM
concept-1708	22	9	)	)	PUNCT
concept-1708	22	10	]	]	PUNCT
concept-1708	22	11	,	,	PUNCT
concept-1708	22	12	inflammation	inflammation	NOUN
concept-1708	22	13	and	and	CCONJ
concept-1708	22	14	proteases	protease	NOUN
concept-1708	22	15	[	[	X
concept-1708	22	16	“	"	PUNCT
concept-1708	22	17	enzymes	enzyme	NOUN
concept-1708	22	18	that	that	PRON
concept-1708	22	19	catalyze	catalyze	VERB
concept-1708	22	20	the	the	DET
concept-1708	22	21	splitting	splitting	NOUN
concept-1708	22	22	of	of	ADP
concept-1708	22	23	proteins	protein	NOUN
concept-1708	22	24	into	into	ADP
concept-1708	22	25	smaller	small	ADJ
concept-1708	22	26	peptide	peptide	NOUN
concept-1708	22	27	fractions	fraction	NOUN
concept-1708	22	28	and	and	CCONJ
concept-1708	22	29	amino	amino	ADJ
concept-1708	22	30	acids	acid	NOUN
concept-1708	22	31	by	by	ADP
concept-1708	22	32	a	a	DET
concept-1708	22	33	process	process	NOUN
concept-1708	22	34	known	know	VERB
concept-1708	22	35	as	as	ADP
concept-1708	22	36	proteolysis	proteolysis	NOUN
concept-1708	22	37	”	"	PUNCT
concept-1708	22	38	(	(	PUNCT
concept-1708	22	39	15	15	NUM
concept-1708	22	40	)	)	PUNCT
concept-1708	22	41	]	]	PUNCT
concept-1708	22	42	”	"	PUNCT
concept-1708	22	43	.	.	PUNCT
concept-1708	23	1	the	the	DET
concept-1708	23	2	most	most	ADV
concept-1708	23	3	common	common	ADJ
concept-1708	23	4	methods	method	NOUN
concept-1708	23	5	of	of	ADP
concept-1708	23	6	modeling	modeling	NOUN
concept-1708	23	7	are	be	AUX
concept-1708	23	8	the	the	DET
concept-1708	23	9	use	use	NOUN
concept-1708	23	10	of	of	ADP
concept-1708	23	11	markov	markov	NOUN
concept-1708	23	12	chains	chain	NOUN
concept-1708	23	13	,	,	PUNCT
concept-1708	23	14	or	or	CCONJ
concept-1708	23	15	partial	partial	ADJ
concept-1708	23	16	differential	differential	NOUN
concept-1708	23	17	equations	equation	NOUN
concept-1708	23	18	,	,	PUNCT
concept-1708	23	19	to	to	PART
concept-1708	23	20	determine	determine	VERB
concept-1708	23	21	the	the	DET
concept-1708	23	22	probability	probability	NOUN
concept-1708	23	23	of	of	ADP
concept-1708	23	24	different	different	ADJ
concept-1708	23	25	metastatic	metastatic	ADJ
concept-1708	23	26	scenarios	scenario	NOUN
concept-1708	23	27	for	for	ADP
concept-1708	23	28	different	different	ADJ
concept-1708	23	29	kinds	kind	NOUN
concept-1708	23	30	of	of	ADP
concept-1708	23	31	cancer	cancer	NOUN
concept-1708	23	32	.	.	PUNCT
concept-1708	24	1	while	while	SCONJ
concept-1708	24	2	some	some	DET
concept-1708	24	3	studies	study	NOUN
concept-1708	24	4	focus	focus	VERB
concept-1708	24	5	on	on	ADP
concept-1708	24	6	cancer	cancer	NOUN
concept-1708	24	7	in	in	ADP
concept-1708	24	8	general	general	ADJ
concept-1708	24	9	and	and	CCONJ
concept-1708	24	10	others	other	NOUN
concept-1708	24	11	focus	focus	VERB
concept-1708	24	12	on	on	ADP
concept-1708	24	13	specific	specific	ADJ
concept-1708	24	14	cancer	cancer	NOUN
concept-1708	24	15	types	type	NOUN
concept-1708	24	16	,	,	PUNCT
concept-1708	24	17	each	each	DET
concept-1708	24	18	study	study	NOUN
concept-1708	24	19	is	be	AUX
concept-1708	24	20	useful	useful	ADJ
concept-1708	24	21	since	since	SCONJ
concept-1708	24	22	the	the	DET
concept-1708	24	23	process	process	NOUN
concept-1708	24	24	of	of	ADP
concept-1708	24	25	metastasis	metastasis	NOUN
concept-1708	24	26	is	be	AUX
concept-1708	24	27	believed	believe	VERB
concept-1708	24	28	to	to	PART
concept-1708	24	29	be	be	AUX
concept-1708	24	30	virtually	virtually	ADV
concept-1708	24	31	the	the	DET
concept-1708	24	32	same	same	ADJ
concept-1708	24	33	for	for	ADP
concept-1708	24	34	all	all	DET
concept-1708	24	35	cancers	cancer	NOUN
concept-1708	24	36	,	,	PUNCT
concept-1708	24	37	even	even	ADV
concept-1708	24	38	though	though	SCONJ
concept-1708	24	39	the	the	DET
concept-1708	24	40	sites	site	NOUN
concept-1708	24	41	change	change	VERB
concept-1708	24	42	from	from	ADP
concept-1708	24	43	type	type	NOUN
concept-1708	24	44	to	to	PART
concept-1708	24	45	type	type	NOUN
concept-1708	24	46	.	.	PUNCT
concept-1708	25	1	this	this	DET
concept-1708	25	2	paper	paper	NOUN
concept-1708	25	3	will	will	AUX
concept-1708	25	4	summarize	summarize	VERB
concept-1708	25	5	five	five	NUM
concept-1708	25	6	existing	exist	VERB
concept-1708	25	7	models	model	NOUN
concept-1708	25	8	and	and	CCONJ
concept-1708	25	9	evaluate	evaluate	VERB
concept-1708	25	10	their	their	PRON
concept-1708	25	11	dissimilarities	dissimilarity	NOUN
concept-1708	25	12	to	to	PART
concept-1708	25	13	determine	determine	VERB
concept-1708	25	14	the	the	DET
concept-1708	25	15	best	good	ADJ
concept-1708	25	16	course	course	NOUN
concept-1708	25	17	of	of	ADP
concept-1708	25	18	action	action	NOUN
concept-1708	25	19	in	in	ADP
concept-1708	25	20	predicting	predict	VERB
concept-1708	25	21	metastasis	metastasis	NOUN
concept-1708	25	22	in	in	ADP
concept-1708	25	23	several	several	ADJ
concept-1708	25	24	types	type	NOUN
concept-1708	25	25	of	of	ADP
concept-1708	25	26	cancer	cancer	NOUN
concept-1708	25	27	.	.	PUNCT
concept-1708	26	1	ii	ii	PROPN
concept-1708	26	2	.	.	PUNCT
concept-1708	26	3	models	model	NOUN
concept-1708	26	4	of	of	ADP
concept-1708	26	5	metastatic	metastatic	ADJ
concept-1708	26	6	cancer	cancer	NOUN
concept-1708	26	7	a.	a.	NOUN
concept-1708	26	8	markov	markov	PROPN
concept-1708	26	9	 	 	SPACE
concept-1708	26	10	chains	chain	VERB
concept-1708	26	11	newton	newton	PROPN
concept-1708	26	12	et	et	PROPN
concept-1708	26	13	al	al	PROPN
concept-1708	26	14	.	.	PROPN
concept-1708	27	1	(	(	PUNCT
concept-1708	27	2	8)	8)	NUM
concept-1708	27	3	took	take	VERB
concept-1708	27	4	a	a	DET
concept-1708	27	5	markov	markov	NOUN
concept-1708	27	6	approach	approach	NOUN
concept-1708	27	7	to	to	PART
concept-1708	27	8	identify	identify	VERB
concept-1708	27	9	the	the	DET
concept-1708	27	10	timeline	timeline	NOUN
concept-1708	27	11	and	and	CCONJ
concept-1708	27	12	design	design	NOUN
concept-1708	27	13	of	of	ADP
concept-1708	27	14	metastatic	metastatic	ADJ
concept-1708	27	15	spread	spread	NOUN
concept-1708	27	16	.	.	PUNCT
concept-1708	28	1	they	they	PRON
concept-1708	28	2	focused	focus	VERB
concept-1708	28	3	on	on	ADP
concept-1708	28	4	lung	lung	NOUN
concept-1708	28	5	cancer	cancer	NOUN
concept-1708	28	6	alone	alone	ADV
concept-1708	28	7	to	to	PART
concept-1708	28	8	gain	gain	VERB
concept-1708	28	9	a	a	DET
concept-1708	28	10	better	well	ADJ
concept-1708	28	11	understanding	understanding	NOUN
concept-1708	28	12	of	of	ADP
concept-1708	28	13	the	the	DET
concept-1708	28	14	exact	exact	ADJ
concept-1708	28	15	process	process	NOUN
concept-1708	28	16	of	of	ADP
concept-1708	28	17	how	how	SCONJ
concept-1708	28	18	the	the	DET
concept-1708	28	19	cancer	cancer	NOUN
concept-1708	28	20	cells	cell	NOUN
concept-1708	28	21	reproduce	reproduce	VERB
concept-1708	28	22	and	and	CCONJ
concept-1708	28	23	spread	spread	VERB
concept-1708	28	24	from	from	ADP
concept-1708	28	25	the	the	DET
concept-1708	28	26	lungs	lung	NOUN
concept-1708	28	27	to	to	ADP
concept-1708	28	28	other	other	ADJ
concept-1708	28	29	parts	part	NOUN
concept-1708	28	30	of	of	ADP
concept-1708	28	31	the	the	DET
concept-1708	28	32	body	body	NOUN
concept-1708	28	33	(	(	PUNCT
concept-1708	28	34	3	3	NUM
concept-1708	28	35	)	)	PUNCT
concept-1708	28	36	.	.	PUNCT
concept-1708	29	1	through	through	ADP
concept-1708	29	2	their	their	PRON
concept-1708	29	3	model	model	NOUN
concept-1708	29	4	,	,	PUNCT
concept-1708	29	5	they	they	PRON
concept-1708	29	6	showed	show	VERB
concept-1708	29	7	that	that	SCONJ
concept-1708	29	8	metastatic	metastatic	ADJ
concept-1708	29	9	cancer	cancer	NOUN
concept-1708	29	10	is	be	AUX
concept-1708	29	11	multi	multi	ADJ
concept-1708	29	12	-	-	ADJ
concept-1708	29	13	directional	directional	ADJ
concept-1708	29	14	,	,	PUNCT
concept-1708	29	15	not	not	PART
concept-1708	29	16	unidirectional	unidirectional	ADJ
concept-1708	29	17	as	as	ADP
concept-1708	29	18	many	many	ADJ
concept-1708	29	19	studies	study	NOUN
concept-1708	29	20	originally	originally	ADV
concept-1708	29	21	believed	believe	VERB
concept-1708	29	22	(	(	PUNCT
concept-1708	29	23	8)	8)	NUM
concept-1708	29	24	.	.	PUNCT
concept-1708	30	1	the	the	DET
concept-1708	30	2	traditional	traditional	ADJ
concept-1708	30	3	“	"	PUNCT
concept-1708	30	4	seed	seed	NOUN
concept-1708	30	5	and	and	CCONJ
concept-1708	30	6	soil	soil	NOUN
concept-1708	30	7	”	"	PUNCT
concept-1708	30	8	view	view	NOUN
concept-1708	30	9	was	be	AUX
concept-1708	30	10	that	that	PRON
concept-1708	30	11	circulating	circulate	VERB
concept-1708	30	12	tumor	tumor	NOUN
concept-1708	30	13	cells	cell	NOUN
concept-1708	30	14	(	(	PUNCT
concept-1708	30	15	ctcs	ctcs	NOUN
concept-1708	30	16	)	)	PUNCT
concept-1708	30	17	are	be	AUX
concept-1708	30	18	responsible	responsible	ADJ
concept-1708	30	19	for	for	ADP
concept-1708	30	20	the	the	DET
concept-1708	30	21	spread	spread	NOUN
concept-1708	30	22	by	by	ADP
concept-1708	30	23	detaching	detach	VERB
concept-1708	30	24	from	from	ADP
concept-1708	30	25	the	the	DET
concept-1708	30	26	primary	primary	ADJ
concept-1708	30	27	tumor	tumor	NOUN
concept-1708	30	28	and	and	CCONJ
concept-1708	30	29	traveling	travel	VERB
concept-1708	30	30	through	through	ADP
concept-1708	30	31	the	the	DET
concept-1708	30	32	bloodstream	bloodstream	NOUN
concept-1708	30	33	and	and	CCONJ
concept-1708	30	34	lymphatic	lymphatic	ADJ
concept-1708	30	35	system	system	NOUN
concept-1708	30	36	to	to	ADP
concept-1708	30	37	new	new	ADJ
concept-1708	30	38	organs	organ	NOUN
concept-1708	30	39	where	where	SCONJ
concept-1708	30	40	,	,	PUNCT
concept-1708	30	41	if	if	SCONJ
concept-1708	30	42	conditions	condition	NOUN
concept-1708	30	43	are	be	AUX
concept-1708	30	44	favorable	favorable	ADJ
concept-1708	30	45	,	,	PUNCT
concept-1708	30	46	they	they	PRON
concept-1708	30	47	are	be	AUX
concept-1708	30	48	able	able	ADJ
concept-1708	30	49	to	to	PART
concept-1708	30	50	reproduce	reproduce	VERB
concept-1708	30	51	and	and	CCONJ
concept-1708	30	52	induce	induce	VERB
concept-1708	30	53	tumor	tumor	NOUN
concept-1708	30	54	growth	growth	NOUN
concept-1708	30	55	.	.	PUNCT
concept-1708	31	1	this	this	DET
concept-1708	31	2	model	model	NOUN
concept-1708	31	3	was	be	AUX
concept-1708	31	4	unidirectional	unidirectional	ADJ
concept-1708	31	5	in	in	ADP
concept-1708	31	6	that	that	SCONJ
concept-1708	31	7	the	the	DET
concept-1708	31	8	ctcs	ctcs	PROPN
concept-1708	31	9	travel	travel	NOUN
concept-1708	31	10	from	from	ADP
concept-1708	31	11	the	the	DET
concept-1708	31	12	primary	primary	NOUN
concept-1708	31	13	to	to	ADP
concept-1708	31	14	the	the	DET
concept-1708	31	15	new	new	ADJ
concept-1708	31	16	site	site	NOUN
concept-1708	31	17	only	only	ADV
concept-1708	31	18	and	and	CCONJ
concept-1708	31	19	do	do	AUX
concept-1708	31	20	not	not	PART
concept-1708	31	21	return	return	VERB
concept-1708	31	22	to	to	ADP
concept-1708	31	23	the	the	DET
concept-1708	31	24	primary	primary	NOUN
concept-1708	31	25	.	.	PUNCT
concept-1708	32	1	newton	newton	PROPN
concept-1708	32	2	et	et	PROPN
concept-1708	32	3	al	al	PROPN
concept-1708	32	4	.	.	PROPN
concept-1708	32	5	cited	cite	VERB
concept-1708	32	6	more	more	ADV
concept-1708	32	7	recent	recent	ADJ
concept-1708	32	8	studies	study	NOUN
concept-1708	32	9	that	that	PRON
concept-1708	32	10	had	have	AUX
concept-1708	32	11	introduced	introduce	VERB
concept-1708	32	12	the	the	DET
concept-1708	32	13	idea	idea	NOUN
concept-1708	32	14	of	of	ADP
concept-1708	32	15	“	"	PUNCT
concept-1708	32	16	self	self	NOUN
concept-1708	32	17	-	-	PUNCT
concept-1708	32	18	seeding	seeding	NOUN
concept-1708	32	19	”	"	PUNCT
concept-1708	32	20	,	,	PUNCT
concept-1708	32	21	where	where	SCONJ
concept-1708	32	22	ctcs	ctcs	NOUN
concept-1708	32	23	that	that	PRON
concept-1708	32	24	have	have	AUX
concept-1708	32	25	left	leave	VERB
concept-1708	32	26	the	the	DET
concept-1708	32	27	primary	primary	ADJ
concept-1708	32	28	site	site	NOUN
concept-1708	32	29	return	return	NOUN
concept-1708	32	30	and	and	CCONJ
concept-1708	32	31	begin	begin	VERB
concept-1708	32	32	reproducing	reproduce	VERB
concept-1708	32	33	again	again	ADV
concept-1708	32	34	.	.	PUNCT
concept-1708	33	1	they	they	PRON
concept-1708	33	2	also	also	ADV
concept-1708	33	3	suggested	suggest	VERB
concept-1708	33	4	that	that	SCONJ
concept-1708	33	5	metastatic	metastatic	ADJ
concept-1708	33	6	self	self	NOUN
concept-1708	33	7	-	-	PUNCT
concept-1708	33	8	seeding	seed	VERB
concept-1708	33	9	(	(	PUNCT
concept-1708	33	10	“	"	PUNCT
concept-1708	33	11	metastasis	metastasis	NOUN
concept-1708	33	12	from	from	ADP
concept-1708	33	13	metastases	metastasis	NOUN
concept-1708	33	14	”	"	PUNCT
concept-1708	33	15	)	)	PUNCT
concept-1708	33	16	may	may	AUX
concept-1708	33	17	even	even	ADV
concept-1708	33	18	be	be	AUX
concept-1708	33	19	possible	possible	ADJ
concept-1708	33	20	.	.	PUNCT
concept-1708	34	1	in	in	ADP
concept-1708	34	2	their	their	PRON
concept-1708	34	3	study	study	NOUN
concept-1708	34	4	,	,	PUNCT
concept-1708	34	5	the	the	DET
concept-1708	34	6	authors	author	NOUN
concept-1708	34	7	defined	define	VERB
concept-1708	34	8	three	three	NUM
concept-1708	34	9	general	general	ADJ
concept-1708	34	10	classes	class	NOUN
concept-1708	34	11	of	of	ADP
concept-1708	34	12	the	the	DET
concept-1708	34	13	cancer	cancer	NOUN
concept-1708	34	14	progression	progression	NOUN
concept-1708	34	15	:	:	PUNCT
concept-1708	34	16	self	self	NOUN
concept-1708	34	17	-	-	PUNCT
concept-1708	34	18	seeding	seeding	NOUN
concept-1708	34	19	of	of	ADP
concept-1708	34	20	the	the	DET
concept-1708	34	21	primary	primary	ADJ
concept-1708	34	22	tumor	tumor	NOUN
concept-1708	34	23	,	,	PUNCT
concept-1708	34	24	reseeding	reseeding	NOUN
concept-1708	34	25	of	of	ADP
concept-1708	34	26	the	the	DET
concept-1708	34	27	primary	primary	ADJ
concept-1708	34	28	tumor	tumor	NOUN
concept-1708	34	29	from	from	ADP
concept-1708	34	30	a	a	DET
concept-1708	34	31	metastatic	metastatic	ADJ
concept-1708	34	32	site	site	NOUN
concept-1708	34	33	,	,	PUNCT
concept-1708	34	34	and	and	CCONJ
concept-1708	34	35	reseeding	reseeding	NOUN
concept-1708	34	36	of	of	ADP
concept-1708	34	37	metastatic	metastatic	ADJ
concept-1708	34	38	tumors	tumor	NOUN
concept-1708	34	39	(	(	PUNCT
concept-1708	34	40	8)	8)	NUM
concept-1708	34	41	.	.	PUNCT
concept-1708	35	1	newton	newton	PROPN
concept-1708	35	2	et	et	PROPN
concept-1708	35	3	al	al	PROPN
concept-1708	35	4	.	.	PROPN
concept-1708	35	5	began	begin	VERB
concept-1708	35	6	by	by	ADP
concept-1708	35	7	developing	develop	VERB
concept-1708	35	8	a	a	DET
concept-1708	35	9	network	network	NOUN
concept-1708	35	10	of	of	ADP
concept-1708	35	11	organs	organ	NOUN
concept-1708	35	12	susceptible	susceptible	ADJ
concept-1708	35	13	to	to	ADP
concept-1708	35	14	the	the	DET
concept-1708	35	15	cancer	cancer	NOUN
concept-1708	35	16	and	and	CCONJ
concept-1708	35	17	assumed	assume	VERB
concept-1708	35	18	that	that	SCONJ
concept-1708	35	19	any	any	DET
concept-1708	35	20	organ	organ	NOUN
concept-1708	35	21	could	could	AUX
concept-1708	35	22	receive	receive	VERB
concept-1708	35	23	the	the	DET
concept-1708	35	24	cancer	cancer	NOUN
concept-1708	35	25	from	from	ADP
concept-1708	35	26	any	any	DET
concept-1708	35	27	other	other	ADJ
concept-1708	35	28	organ	organ	NOUN
concept-1708	35	29	in	in	ADP
concept-1708	35	30	the	the	DET
concept-1708	35	31	chain	chain	NOUN
concept-1708	35	32	.	.	PUNCT
concept-1708	36	1	since	since	SCONJ
concept-1708	36	2	they	they	PRON
concept-1708	36	3	were	be	AUX
concept-1708	36	4	using	use	VERB
concept-1708	36	5	the	the	DET
concept-1708	36	6	data	datum	NOUN
concept-1708	36	7	from	from	ADP
concept-1708	36	8	autopsy	autopsy	ADJ
concept-1708	36	9	results	result	NOUN
concept-1708	36	10	after	after	ADP
concept-1708	36	11	long	long	ADJ
concept-1708	36	12	-	-	PUNCT
concept-1708	36	13	term	term	NOUN
concept-1708	36	14	progression	progression	NOUN
concept-1708	36	15	of	of	ADP
concept-1708	36	16	the	the	DET
concept-1708	36	17	disease	disease	NOUN
concept-1708	36	18	,	,	PUNCT
concept-1708	36	19	they	they	PRON
concept-1708	36	20	started	start	VERB
concept-1708	36	21	the	the	DET
concept-1708	36	22	study	study	NOUN
concept-1708	36	23	already	already	ADV
concept-1708	36	24	  	  	SPACE
concept-1708	36	25	knowing	know	VERB
concept-1708	36	26	the	the	DET
concept-1708	36	27	final	final	ADJ
concept-1708	36	28	steady	steady	ADJ
concept-1708	36	29	-	-	PUNCT
concept-1708	36	30	state	state	NOUN
concept-1708	36	31	vector	vector	NOUN
concept-1708	36	32	that	that	PRON
concept-1708	36	33	would	would	AUX
concept-1708	36	34	normally	normally	ADV
concept-1708	36	35	be	be	AUX
concept-1708	36	36	found	find	VERB
concept-1708	36	37	after	after	ADP
concept-1708	36	38	many	many	ADJ
concept-1708	36	39	iterations	iteration	NOUN
concept-1708	36	40	of	of	ADP
concept-1708	36	41	the	the	DET
concept-1708	36	42	transitional	transitional	ADJ
concept-1708	36	43	matrix	matrix	NOUN
concept-1708	36	44	.	.	PUNCT
concept-1708	37	1	they	they	PRON
concept-1708	37	2	then	then	ADV
concept-1708	37	3	used	use	VERB
concept-1708	37	4	an	an	DET
concept-1708	37	5	iterative	iterative	ADJ
concept-1708	37	6	monte	monte	PROPN
concept-1708	37	7	carlo	carlo	PROPN
concept-1708	37	8	method	method	NOUN
concept-1708	37	9	—	—	PUNCT
concept-1708	37	10	one	one	NOUN
concept-1708	37	11	that	that	PRON
concept-1708	37	12	generates	generate	VERB
concept-1708	37	13	random	random	ADJ
concept-1708	37	14	numbers	number	NOUN
concept-1708	37	15	and	and	CCONJ
concept-1708	37	16	observes	observe	VERB
concept-1708	37	17	the	the	DET
concept-1708	37	18	fraction	fraction	NOUN
concept-1708	37	19	of	of	ADP
concept-1708	37	20	the	the	DET
concept-1708	37	21	numbers	number	NOUN
concept-1708	37	22	that	that	PRON
concept-1708	37	23	obey	obey	VERB
concept-1708	37	24	a	a	DET
concept-1708	37	25	property	property	NOUN
concept-1708	37	26	or	or	CCONJ
concept-1708	37	27	properties	property	NOUN
concept-1708	37	28	(	(	PUNCT
concept-1708	37	29	14)—to	14)—to	NUM
concept-1708	37	30	solve	solve	NOUN
concept-1708	37	31	for	for	ADP
concept-1708	37	32	the	the	DET
concept-1708	37	33	probabilities	probability	NOUN
concept-1708	37	34	of	of	ADP
concept-1708	37	35	cancer	cancer	NOUN
concept-1708	37	36	cell	cell	NOUN
concept-1708	37	37	transition	transition	NOUN
concept-1708	37	38	between	between	ADP
concept-1708	37	39	each	each	DET
concept-1708	37	40	organ	organ	NOUN
concept-1708	37	41	to	to	PART
concept-1708	37	42	find	find	VERB
concept-1708	37	43	the	the	DET
concept-1708	37	44	original	original	ADJ
concept-1708	37	45	p	p	ADJ
concept-1708	37	46	transitional	transitional	ADJ
concept-1708	37	47	matrix	matrix	NOUN
concept-1708	37	48	.	.	PUNCT
concept-1708	38	1	they	they	PRON
concept-1708	38	2	applied	apply	VERB
concept-1708	38	3	a	a	DET
concept-1708	38	4	discrete	discrete	ADJ
concept-1708	38	5	markov	markov	NOUN
concept-1708	38	6	chain	chain	NOUN
concept-1708	38	7	system	system	NOUN
concept-1708	38	8	to	to	ADP
concept-1708	38	9	this	this	DET
concept-1708	38	10	p	p	NOUN
concept-1708	38	11	matrix	matrix	NOUN
concept-1708	38	12	to	to	PART
concept-1708	38	13	determine	determine	VERB
concept-1708	38	14	the	the	DET
concept-1708	38	15	probabilities	probability	NOUN
concept-1708	38	16	of	of	ADP
concept-1708	38	17	different	different	ADJ
concept-1708	38	18	metastatic	metastatic	ADJ
concept-1708	38	19	routes	route	NOUN
concept-1708	38	20	.	.	PUNCT
concept-1708	39	1	from	from	ADP
concept-1708	39	2	this	this	DET
concept-1708	39	3	data	data	NOUN
concept-1708	39	4	,	,	PUNCT
concept-1708	39	5	they	they	PRON
concept-1708	39	6	developed	develop	VERB
concept-1708	39	7	the	the	DET
concept-1708	39	8	diagram	diagram	NOUN
concept-1708	39	9	below	below	ADV
concept-1708	39	10	to	to	PART
concept-1708	39	11	show	show	VERB
concept-1708	39	12	how	how	SCONJ
concept-1708	39	13	the	the	DET
concept-1708	39	14	cancer	cancer	NOUN
concept-1708	39	15	can	can	AUX
concept-1708	39	16	spread	spread	VERB
concept-1708	39	17	from	from	ADP
concept-1708	39	18	the	the	DET
concept-1708	39	19	lungs	lung	NOUN
concept-1708	39	20	.	.	PUNCT
concept-1708	40	1	the	the	DET
concept-1708	40	2	innermost	innermost	NOUN
concept-1708	40	3	ring	ring	NOUN
concept-1708	40	4	consists	consist	VERB
concept-1708	40	5	of	of	ADP
concept-1708	40	6	“	"	PUNCT
concept-1708	40	7	first	first	ADJ
concept-1708	40	8	-	-	PUNCT
concept-1708	40	9	order	order	NOUN
concept-1708	40	10	”	"	PUNCT
concept-1708	40	11	sites	site	NOUN
concept-1708	40	12	,	,	PUNCT
concept-1708	40	13	ones	one	NOUN
concept-1708	40	14	in	in	ADP
concept-1708	40	15	direct	direct	ADJ
concept-1708	40	16	contact	contact	NOUN
concept-1708	40	17	with	with	ADP
concept-1708	40	18	the	the	DET
concept-1708	40	19	lungs	lung	NOUN
concept-1708	40	20	,	,	PUNCT
concept-1708	40	21	starting	start	VERB
concept-1708	40	22	with	with	ADP
concept-1708	40	23	the	the	DET
concept-1708	40	24	most	most	ADV
concept-1708	40	25	probable	probable	ADJ
concept-1708	40	26	first	first	ADJ
concept-1708	40	27	step	step	NOUN
concept-1708	40	28	of	of	ADP
concept-1708	40	29	metastasis	metastasis	NOUN
concept-1708	40	30	(	(	PUNCT
concept-1708	40	31	regional	regional	ADJ
concept-1708	40	32	lymph	lymph	NOUN
concept-1708	40	33	nodes	nod	VERB
concept-1708	40	34	)	)	PUNCT
concept-1708	40	35	at	at	ADP
concept-1708	40	36	12:00	12:00	NUM
concept-1708	40	37	with	with	ADP
concept-1708	40	38	probability	probability	NOUN
concept-1708	40	39	decreasing	decrease	VERB
concept-1708	40	40	clockwise	clockwise	NOUN
concept-1708	40	41	around	around	ADP
concept-1708	40	42	the	the	DET
concept-1708	40	43	circle	circle	NOUN
concept-1708	40	44	to	to	ADP
concept-1708	40	45	the	the	DET
concept-1708	40	46	least	least	ADV
concept-1708	40	47	likely	likely	ADJ
concept-1708	40	48	first	first	ADJ
concept-1708	40	49	step	step	NOUN
concept-1708	40	50	of	of	ADP
concept-1708	40	51	metastasis	metastasis	NOUN
concept-1708	40	52	(	(	PUNCT
concept-1708	40	53	skeletal	skeletal	ADJ
concept-1708	40	54	muscle	muscle	NOUN
concept-1708	40	55	)	)	PUNCT
concept-1708	40	56	.	.	PUNCT
concept-1708	41	1	the	the	DET
concept-1708	41	2	outer	outer	ADJ
concept-1708	41	3	ring	ring	NOUN
concept-1708	41	4	consists	consist	VERB
concept-1708	41	5	of	of	ADP
concept-1708	41	6	“	"	PUNCT
concept-1708	41	7	second	second	ADJ
concept-1708	41	8	-	-	PUNCT
concept-1708	41	9	order	order	NOUN
concept-1708	41	10	”	"	PUNCT
concept-1708	41	11	sites	site	NOUN
concept-1708	41	12	,	,	PUNCT
concept-1708	41	13	ones	one	NOUN
concept-1708	41	14	where	where	SCONJ
concept-1708	41	15	,	,	PUNCT
concept-1708	41	16	for	for	SCONJ
concept-1708	41	17	cancer	cancer	NOUN
concept-1708	41	18	to	to	PART
concept-1708	41	19	metastasize	metastasize	VERB
concept-1708	41	20	,	,	PUNCT
concept-1708	41	21	it	it	PRON
concept-1708	41	22	usually	usually	ADV
concept-1708	41	23	must	must	AUX
concept-1708	41	24	first	first	ADV
concept-1708	41	25	pass	pass	VERB
concept-1708	41	26	through	through	ADP
concept-1708	41	27	a	a	DET
concept-1708	41	28	first	first	ADJ
concept-1708	41	29	-	-	PUNCT
concept-1708	41	30	order	order	NOUN
concept-1708	41	31	site	site	NOUN
concept-1708	41	32	(	(	PUNCT
concept-1708	41	33	8)	8)	NUM
concept-1708	41	34	.	.	PUNCT
concept-1708	42	1	their	their	PRON
concept-1708	42	2	diagram	diagram	NOUN
concept-1708	42	3	accounts	account	VERB
concept-1708	42	4	for	for	ADP
concept-1708	42	5	the	the	DET
concept-1708	42	6	multi	multi	ADJ
concept-1708	42	7	-	-	ADJ
concept-1708	42	8	directional	directional	ADJ
concept-1708	42	9	steps	step	NOUN
concept-1708	42	10	that	that	PRON
concept-1708	42	11	allow	allow	VERB
concept-1708	42	12	the	the	DET
concept-1708	42	13	cancer	cancer	NOUN
concept-1708	42	14	to	to	PART
concept-1708	42	15	feed	feed	VERB
concept-1708	42	16	back	back	ADV
concept-1708	42	17	into	into	ADP
concept-1708	42	18	the	the	DET
concept-1708	42	19	lung	lung	NOUN
concept-1708	42	20	or	or	CCONJ
concept-1708	42	21	any	any	DET
concept-1708	42	22	metastatic	metastatic	ADJ
concept-1708	42	23	site	site	NOUN
concept-1708	42	24	with	with	ADP
concept-1708	42	25	arrows	arrow	NOUN
concept-1708	42	26	directed	direct	VERB
concept-1708	42	27	back	back	ADV
concept-1708	42	28	toward	toward	ADP
concept-1708	42	29	those	those	DET
concept-1708	42	30	sites	site	NOUN
concept-1708	42	31	.	.	PUNCT
concept-1708	43	1	overall	overall	ADV
concept-1708	43	2	,	,	PUNCT
concept-1708	43	3	they	they	PRON
concept-1708	43	4	identified	identify	VERB
concept-1708	43	5	756	756	NUM
concept-1708	43	6	possible	possible	ADJ
concept-1708	43	7	two	two	NUM
concept-1708	43	8	-	-	PUNCT
concept-1708	43	9	step	step	NOUN
concept-1708	43	10	paths	path	NOUN
concept-1708	43	11	.	.	PUNCT
concept-1708	44	1	they	they	PRON
concept-1708	44	2	defined	define	VERB
concept-1708	44	3	the	the	DET
concept-1708	44	4	strongest	strong	ADJ
concept-1708	44	5	metastasis	metastasis	NOUN
concept-1708	44	6	re	re	NOUN
concept-1708	44	7	-	-	NOUN
concept-1708	44	8	seeders	seeder	NOUN
concept-1708	44	9	as	as	ADP
concept-1708	44	10	lymph	lymph	NOUN
concept-1708	44	11	nodes	node	NOUN
concept-1708	44	12	,	,	PUNCT
concept-1708	44	13	followed	follow	VERB
concept-1708	44	14	by	by	ADP
concept-1708	44	15	liver	liver	NOUN
concept-1708	44	16	,	,	PUNCT
concept-1708	44	17	adrenal	adrenal	ADJ
concept-1708	44	18	bone	bone	NOUN
concept-1708	44	19	,	,	PUNCT
concept-1708	44	20	and	and	CCONJ
concept-1708	44	21	kidney	kidney	NOUN
concept-1708	44	22	(	(	PUNCT
concept-1708	44	23	8)	8)	NUM
concept-1708	44	24	.	.	PUNCT
concept-1708	45	1	they	they	PRON
concept-1708	45	2	did	do	VERB
concept-1708	45	3	a	a	DET
concept-1708	45	4	convergence	convergence	NOUN
concept-1708	45	5	analysis	analysis	NOUN
concept-1708	45	6	of	of	ADP
concept-1708	45	7	their	their	PRON
concept-1708	45	8	algorithm	algorithm	NOUN
concept-1708	45	9	against	against	ADP
concept-1708	45	10	the	the	DET
concept-1708	45	11	data	datum	NOUN
concept-1708	45	12	set	set	VERB
concept-1708	45	13	and	and	CCONJ
concept-1708	45	14	noted	note	VERB
concept-1708	45	15	that	that	SCONJ
concept-1708	45	16	the	the	DET
concept-1708	45	17	only	only	ADJ
concept-1708	45	18	non	non	ADJ
concept-1708	45	19	-	-	ADJ
concept-1708	45	20	convergence	convergence	NOUN
concept-1708	45	21	occurred	occur	VERB
concept-1708	45	22	when	when	SCONJ
concept-1708	45	23	they	they	PRON
concept-1708	45	24	eliminated	eliminate	VERB
concept-1708	45	25	any	any	DET
concept-1708	45	26	possibility	possibility	NOUN
concept-1708	45	27	of	of	ADP
concept-1708	45	28	primary	primary	ADJ
concept-1708	45	29	metastasis	metastasis	NOUN
concept-1708	45	30	or	or	CCONJ
concept-1708	45	31	metastatic	metastatic	ADJ
concept-1708	45	32	re	re	NOUN
concept-1708	45	33	-	-	NOUN
concept-1708	45	34	seeding	seed	VERB
concept-1708	45	35	and	and	CCONJ
concept-1708	45	36	made	make	VERB
concept-1708	45	37	the	the	DET
concept-1708	45	38	model	model	NOUN
concept-1708	45	39	unidirectional	unidirectional	ADJ
concept-1708	45	40	.	.	PUNCT
concept-1708	46	1	however	however	ADV
concept-1708	46	2	,	,	PUNCT
concept-1708	46	3	when	when	SCONJ
concept-1708	46	4	all	all	DET
concept-1708	46	5	connections	connection	NOUN
concept-1708	46	6	in	in	ADP
concept-1708	46	7	the	the	DET
concept-1708	46	8	diagram	diagram	NOUN
concept-1708	46	9	were	be	AUX
concept-1708	46	10	allowed	allow	VERB
concept-1708	46	11	,	,	PUNCT
concept-1708	46	12	the	the	DET
concept-1708	46	13	algorithm	algorithm	NOUN
concept-1708	46	14	converged	converge	VERB
concept-1708	46	15	to	to	ADP
concept-1708	46	16	a	a	DET
concept-1708	46	17	solution	solution	NOUN
concept-1708	46	18	and	and	CCONJ
concept-1708	46	19	produced	produce	VERB
concept-1708	46	20	a	a	DET
concept-1708	46	21	transitional	transitional	ADJ
concept-1708	46	22	matrix	matrix	NOUN
concept-1708	46	23	with	with	ADP
concept-1708	46	24	many	many	ADJ
concept-1708	46	25	connections	connection	NOUN
concept-1708	46	26	from	from	ADP
concept-1708	46	27	site	site	NOUN
concept-1708	46	28	to	to	PART
concept-1708	46	29	site	site	VERB
concept-1708	46	30	.	.	PUNCT
concept-1708	47	1	they	they	PRON
concept-1708	47	2	noted	note	VERB
concept-1708	47	3	that	that	SCONJ
concept-1708	47	4	after	after	ADP
concept-1708	47	5	two	two	NUM
concept-1708	47	6	iterations	iteration	NOUN
concept-1708	47	7	of	of	ADP
concept-1708	47	8	their	their	PRON
concept-1708	47	9	markov	markov	NOUN
concept-1708	47	10	chain	chain	NOUN
concept-1708	47	11	,	,	PUNCT
concept-1708	47	12	the	the	DET
concept-1708	47	13	state	state	NOUN
concept-1708	47	14	-	-	PUNCT
concept-1708	47	15	vector	vector	NOUN
concept-1708	47	16	had	have	AUX
concept-1708	47	17	almost	almost	ADV
concept-1708	47	18	converged	converge	VERB
concept-1708	47	19	to	to	ADP
concept-1708	47	20	the	the	DET
concept-1708	47	21	steady	steady	ADJ
concept-1708	47	22	-	-	PUNCT
concept-1708	47	23	state	state	NOUN
concept-1708	47	24	vector	vector	NOUN
concept-1708	47	25	for	for	ADP
concept-1708	47	26	metastatic	metastatic	ADJ
concept-1708	47	27	tumors	tumor	NOUN
concept-1708	47	28	,	,	PUNCT
concept-1708	47	29	effectively	effectively	ADV
concept-1708	47	30	showing	show	VERB
concept-1708	47	31	that	that	SCONJ
concept-1708	47	32	lung	lung	NOUN
concept-1708	47	33	cancer	cancer	NOUN
concept-1708	47	34	metastasis	metastasis	NOUN
concept-1708	47	35	is	be	AUX
concept-1708	47	36	a	a	DET
concept-1708	47	37	two	two	NUM
concept-1708	47	38	-	-	PUNCT
concept-1708	47	39	step	step	NOUN
concept-1708	47	40	process	process	NOUN
concept-1708	47	41	(	(	PUNCT
concept-1708	47	42	8)	8)	NUM
concept-1708	47	43	.	.	PUNCT
concept-1708	47	44	  	  	SPACE
concept-1708	47	45	diagram	diagram	NOUN
concept-1708	47	46	of	of	ADP
concept-1708	47	47	metastatic	metastatic	ADJ
concept-1708	47	48	spread	spread	NOUN
concept-1708	47	49	of	of	ADP
concept-1708	47	50	cancer	cancer	NOUN
concept-1708	47	51	from	from	ADP
concept-1708	47	52	the	the	DET
concept-1708	47	53	lungs	lung	NOUN
concept-1708	47	54	(	(	PUNCT
concept-1708	47	55	8)	8)	NUM
concept-1708	47	56	through	through	ADP
concept-1708	47	57	their	their	PRON
concept-1708	47	58	study	study	NOUN
concept-1708	47	59	,	,	PUNCT
concept-1708	47	60	newton	newton	PROPN
concept-1708	47	61	et	et	PROPN
concept-1708	47	62	al	al	PROPN
concept-1708	47	63	.	.	PROPN
concept-1708	47	64	were	be	AUX
concept-1708	47	65	able	able	ADJ
concept-1708	47	66	to	to	PART
concept-1708	47	67	identify	identify	VERB
concept-1708	47	68	sites	site	NOUN
concept-1708	47	69	as	as	ADP
concept-1708	47	70	either	either	DET
concept-1708	47	71	contributors	contributor	NOUN
concept-1708	47	72	to	to	PART
concept-1708	47	73	metastatic	metastatic	VERB
concept-1708	47	74	spread	spread	NOUN
concept-1708	47	75	or	or	CCONJ
concept-1708	47	76	as	as	ADP
concept-1708	47	77	absorbing	absorb	VERB
concept-1708	47	78	states	state	NOUN
concept-1708	47	79	by	by	ADP
concept-1708	47	80	comparing	compare	VERB
concept-1708	47	81	the	the	DET
concept-1708	47	82	probability	probability	NOUN
concept-1708	47	83	of	of	ADP
concept-1708	47	84	cancer	cancer	NOUN
concept-1708	47	85	cell	cell	NOUN
concept-1708	47	86	movement	movement	NOUN
concept-1708	47	87	out	out	ADP
concept-1708	47	88	of	of	ADP
concept-1708	47	89	the	the	DET
concept-1708	47	90	site	site	NOUN
concept-1708	47	91	(	(	PUNCT
concept-1708	47	92	pout	pout	INTJ
concept-1708	47	93	)	)	PUNCT
concept-1708	47	94	over	over	ADP
concept-1708	47	95	the	the	DET
concept-1708	47	96	probability	probability	NOUN
concept-1708	47	97	into	into	ADP
concept-1708	47	98	the	the	DET
concept-1708	47	99	site	site	NOUN
concept-1708	47	100	(	(	PUNCT
concept-1708	47	101	pin	pin	NOUN
concept-1708	47	102	)	)	PUNCT
concept-1708	47	103	(	(	PUNCT
concept-1708	47	104	8)	8)	NUM
concept-1708	47	105	.	.	PUNCT
concept-1708	48	1	they	they	PRON
concept-1708	48	2	defined	define	VERB
concept-1708	48	3	“	"	PUNCT
concept-1708	48	4	spreaders	spreader	NOUN
concept-1708	48	5	”	"	PUNCT
concept-1708	48	6	like	like	ADP
concept-1708	48	7	the	the	DET
concept-1708	48	8	adrenal	adrenal	ADJ
concept-1708	48	9	gland	gland	NOUN
concept-1708	48	10	and	and	CCONJ
concept-1708	48	11	kidney	kidney	NOUN
concept-1708	48	12	as	as	ADP
concept-1708	48	13	sites	site	NOUN
concept-1708	48	14	where	where	SCONJ
concept-1708	48	15	pout	pout	VERB
concept-1708	48	16	>	>	X
concept-1708	48	17	pin	pin	NOUN
concept-1708	48	18	,	,	PUNCT
concept-1708	48	19	meaning	mean	VERB
concept-1708	48	20	that	that	SCONJ
concept-1708	48	21	if	if	SCONJ
concept-1708	48	22	the	the	DET
concept-1708	48	23	cancer	cancer	NOUN
concept-1708	48	24	came	come	VERB
concept-1708	48	25	to	to	ADP
concept-1708	48	26	those	those	DET
concept-1708	48	27	organs	organ	NOUN
concept-1708	48	28	it	it	PRON
concept-1708	48	29	would	would	AUX
concept-1708	48	30	likely	likely	ADV
concept-1708	48	31	be	be	AUX
concept-1708	48	32	dispersed	disperse	VERB
concept-1708	48	33	to	to	ADP
concept-1708	48	34	other	other	ADJ
concept-1708	48	35	organs	organ	NOUN
concept-1708	48	36	as	as	ADV
concept-1708	48	37	well	well	ADV
concept-1708	48	38	.	.	PUNCT
concept-1708	49	1	contrarily	contrarily	ADV
concept-1708	49	2	,	,	PUNCT
concept-1708	49	3	they	they	PRON
concept-1708	49	4	called	call	VERB
concept-1708	49	5	sites	site	NOUN
concept-1708	49	6	like	like	ADP
concept-1708	49	7	regional	regional	ADJ
concept-1708	49	8	lymph	lymph	NOUN
concept-1708	49	9	nodes	node	NOUN
concept-1708	49	10	,	,	PUNCT
concept-1708	49	11	the	the	DET
concept-1708	49	12	liver	liver	NOUN
concept-1708	49	13	,	,	PUNCT
concept-1708	49	14	and	and	CCONJ
concept-1708	49	15	bone	bone	NOUN
concept-1708	49	16	“	"	PUNCT
concept-1708	49	17	sponges	sponge	NOUN
concept-1708	49	18	”	"	PUNCT
concept-1708	49	19	,	,	PUNCT
concept-1708	49	20	where	where	SCONJ
concept-1708	49	21	pin	pin	PROPN
concept-1708	49	22	>	>	X
concept-1708	49	23	pout	pout	PROPN
concept-1708	49	24	,	,	PUNCT
concept-1708	49	25	implying	imply	VERB
concept-1708	49	26	that	that	SCONJ
concept-1708	49	27	the	the	DET
concept-1708	49	28	cancer	cancer	NOUN
concept-1708	49	29	would	would	AUX
concept-1708	49	30	be	be	AUX
concept-1708	49	31	limited	limit	VERB
concept-1708	49	32	to	to	ADP
concept-1708	49	33	these	these	DET
concept-1708	49	34	locations	location	NOUN
concept-1708	49	35	instead	instead	ADV
concept-1708	49	36	of	of	ADP
concept-1708	49	37	traveling	travel	VERB
concept-1708	49	38	and	and	CCONJ
concept-1708	49	39	metastasizing	metastasizing	NOUN
concept-1708	49	40	elsewhere	elsewhere	ADV
concept-1708	49	41	in	in	ADP
concept-1708	49	42	the	the	DET
concept-1708	49	43	body	body	NOUN
concept-1708	49	44	.	.	PUNCT
concept-1708	50	1	their	their	PRON
concept-1708	50	2	study	study	NOUN
concept-1708	50	3	included	include	VERB
concept-1708	50	4	a	a	DET
concept-1708	50	5	graph	graph	NOUN
concept-1708	50	6	of	of	ADP
concept-1708	50	7	time	time	NOUN
concept-1708	50	8	-	-	PUNCT
concept-1708	50	9	progression	progression	NOUN
concept-1708	50	10	of	of	ADP
concept-1708	50	11	the	the	DET
concept-1708	50	12	cancer	cancer	NOUN
concept-1708	50	13	through	through	ADP
concept-1708	50	14	the	the	DET
concept-1708	50	15	different	different	ADJ
concept-1708	50	16	metastasis	metastasis	NOUN
concept-1708	50	17	sites	site	NOUN
concept-1708	50	18	.	.	PUNCT
concept-1708	51	1	while	while	SCONJ
concept-1708	51	2	a	a	DET
concept-1708	51	3	patient	patient	NOUN
concept-1708	51	4	’s	’s	PART
concept-1708	51	5	doctor	doctor	NOUN
concept-1708	51	6	may	may	AUX
concept-1708	51	7	not	not	PART
concept-1708	51	8	be	be	AUX
concept-1708	51	9	able	able	ADJ
concept-1708	51	10	to	to	PART
concept-1708	51	11	definitively	definitively	ADV
concept-1708	51	12	predict	predict	VERB
concept-1708	51	13	the	the	DET
concept-1708	51	14	location	location	NOUN
concept-1708	51	15	of	of	ADP
concept-1708	51	16	his	his	PRON
concept-1708	51	17	or	or	CCONJ
concept-1708	51	18	her	her	PRON
concept-1708	51	19	cancer	cancer	NOUN
concept-1708	51	20	’s	’s	PART
concept-1708	51	21	first	first	ADJ
concept-1708	51	22	metastasis	metastasis	NOUN
concept-1708	51	23	,	,	PUNCT
concept-1708	51	24	this	this	DET
concept-1708	51	25	graph	graph	NOUN
concept-1708	51	26	would	would	AUX
concept-1708	51	27	be	be	AUX
concept-1708	51	28	helpful	helpful	ADJ
concept-1708	51	29	in	in	ADP
concept-1708	51	30	determining	determine	VERB
concept-1708	51	31	the	the	DET
concept-1708	51	32	timeline	timeline	NOUN
concept-1708	51	33	and	and	CCONJ
concept-1708	51	34	future	future	ADJ
concept-1708	51	35	progression	progression	NOUN
concept-1708	51	36	of	of	ADP
concept-1708	51	37	the	the	DET
concept-1708	51	38	cancer	cancer	NOUN
concept-1708	51	39	once	once	SCONJ
concept-1708	51	40	the	the	DET
concept-1708	51	41	first	first	ADJ
concept-1708	51	42	site	site	NOUN
concept-1708	51	43	is	be	AUX
concept-1708	51	44	known	know	VERB
concept-1708	51	45	.	.	PUNCT
concept-1708	52	1	the	the	DET
concept-1708	52	2	graph	graph	NOUN
concept-1708	52	3	can	can	AUX
concept-1708	52	4	also	also	ADV
concept-1708	52	5	be	be	AUX
concept-1708	52	6	used	use	VERB
concept-1708	52	7	to	to	PART
concept-1708	52	8	suggest	suggest	VERB
concept-1708	52	9	treatment	treatment	NOUN
concept-1708	52	10	  	  	SPACE
concept-1708	52	11	methods	method	NOUN
concept-1708	52	12	of	of	ADP
concept-1708	52	13	a	a	DET
concept-1708	52	14	specific	specific	ADJ
concept-1708	52	15	cancer	cancer	NOUN
concept-1708	52	16	progression	progression	NOUN
concept-1708	52	17	,	,	PUNCT
concept-1708	52	18	especially	especially	ADV
concept-1708	52	19	whether	whether	SCONJ
concept-1708	52	20	resections	resection	NOUN
concept-1708	52	21	at	at	ADP
concept-1708	52	22	certain	certain	ADJ
concept-1708	52	23	sites	site	NOUN
concept-1708	52	24	would	would	AUX
concept-1708	52	25	be	be	AUX
concept-1708	52	26	helpful	helpful	ADJ
concept-1708	52	27	or	or	CCONJ
concept-1708	52	28	of	of	ADP
concept-1708	52	29	no	no	DET
concept-1708	52	30	significant	significant	ADJ
concept-1708	52	31	benefit	benefit	NOUN
concept-1708	52	32	to	to	ADP
concept-1708	52	33	the	the	DET
concept-1708	52	34	patient	patient	NOUN
concept-1708	52	35	.	.	PUNCT
concept-1708	53	1	timeline	timeline	NOUN
concept-1708	53	2	of	of	ADP
concept-1708	53	3	lung	lung	NOUN
concept-1708	53	4	cancer	cancer	NOUN
concept-1708	53	5	progression	progression	NOUN
concept-1708	53	6	and	and	CCONJ
concept-1708	53	7	treatment	treatment	NOUN
concept-1708	53	8	(	(	PUNCT
concept-1708	53	9	8)	8)	NUM
concept-1708	53	10	liotta	liotta	NOUN
concept-1708	53	11	et	et	PROPN
concept-1708	53	12	al	al	PROPN
concept-1708	53	13	.	.	PROPN
concept-1708	54	1	also	also	ADV
concept-1708	54	2	used	use	VERB
concept-1708	54	3	a	a	DET
concept-1708	54	4	markov	markov	NOUN
concept-1708	54	5	approach	approach	NOUN
concept-1708	54	6	,	,	PUNCT
concept-1708	54	7	but	but	CCONJ
concept-1708	54	8	instead	instead	ADV
concept-1708	54	9	of	of	ADP
concept-1708	54	10	only	only	ADV
concept-1708	54	11	studying	study	VERB
concept-1708	54	12	the	the	DET
concept-1708	54	13	movement	movement	NOUN
concept-1708	54	14	of	of	ADP
concept-1708	54	15	single	single	ADJ
concept-1708	54	16	ctcs	ctcs	NOUN
concept-1708	54	17	,	,	PUNCT
concept-1708	54	18	they	they	PRON
concept-1708	54	19	considered	consider	VERB
concept-1708	54	20	that	that	SCONJ
concept-1708	54	21	cancer	cancer	NOUN
concept-1708	54	22	cells	cell	NOUN
concept-1708	54	23	travel	travel	VERB
concept-1708	54	24	in	in	ADP
concept-1708	54	25	masses	masse	NOUN
concept-1708	54	26	of	of	ADP
concept-1708	54	27	assorted	assorted	ADJ
concept-1708	54	28	size	size	NOUN
concept-1708	54	29	(	(	PUNCT
concept-1708	54	30	2	2	NUM
concept-1708	54	31	)	)	PUNCT
concept-1708	54	32	.	.	PUNCT
concept-1708	55	1	their	their	PRON
concept-1708	55	2	model	model	NOUN
concept-1708	55	3	consists	consist	VERB
concept-1708	55	4	of	of	ADP
concept-1708	55	5	three	three	NUM
concept-1708	55	6	types	type	NOUN
concept-1708	55	7	of	of	ADP
concept-1708	55	8	tumor	tumor	NOUN
concept-1708	55	9	clumps	clump	NOUN
concept-1708	55	10	:	:	PUNCT
concept-1708	55	11	“	"	PUNCT
concept-1708	55	12	tumor	tumor	NOUN
concept-1708	55	13	cell	cell	NOUN
concept-1708	55	14	clumps	clump	NOUN
concept-1708	55	15	in	in	ADP
concept-1708	55	16	the	the	DET
concept-1708	55	17	circulation	circulation	NOUN
concept-1708	55	18	,	,	PUNCT
concept-1708	55	19	tumor	tumor	NOUN
concept-1708	55	20	cells	cell	NOUN
concept-1708	55	21	clumps	clump	NOUN
concept-1708	55	22	arrested	arrest	VERB
concept-1708	55	23	in	in	ADP
concept-1708	55	24	the	the	DET
concept-1708	55	25	pulmonary	pulmonary	ADJ
concept-1708	55	26	capillary	capillary	ADJ
concept-1708	55	27	bed	bed	NOUN
concept-1708	55	28	,	,	PUNCT
concept-1708	55	29	and	and	CCONJ
concept-1708	55	30	pulmonary	pulmonary	ADJ
concept-1708	55	31	metastatic	metastatic	ADJ
concept-1708	55	32	foci	focus	NOUN
concept-1708	55	33	”	"	PUNCT
concept-1708	55	34	(	(	PUNCT
concept-1708	55	35	2	2	NUM
concept-1708	55	36	)	)	PUNCT
concept-1708	55	37	.	.	PUNCT
concept-1708	56	1	they	they	PRON
concept-1708	56	2	used	use	VERB
concept-1708	56	3	their	their	PRON
concept-1708	56	4	experimental	experimental	ADJ
concept-1708	56	5	data	datum	NOUN
concept-1708	56	6	to	to	PART
concept-1708	56	7	base	base	VERB
concept-1708	56	8	their	their	PRON
concept-1708	56	9	study	study	NOUN
concept-1708	56	10	on	on	ADP
concept-1708	56	11	the	the	DET
concept-1708	56	12	assumptions	assumption	NOUN
concept-1708	56	13	that	that	PRON
concept-1708	56	14	clump	clump	VERB
concept-1708	56	15	death	death	NOUN
concept-1708	56	16	rate	rate	NOUN
concept-1708	56	17	is	be	AUX
concept-1708	56	18	inversely	inversely	ADV
concept-1708	56	19	proportional	proportional	ADJ
concept-1708	56	20	to	to	ADP
concept-1708	56	21	its	its	PRON
concept-1708	56	22	size	size	NOUN
concept-1708	56	23	,	,	PUNCT
concept-1708	56	24	that	that	SCONJ
concept-1708	56	25	colonization	colonization	NOUN
concept-1708	56	26	rate	rate	NOUN
concept-1708	56	27	is	be	AUX
concept-1708	56	28	linearly	linearly	ADV
concept-1708	56	29	correlated	correlate	VERB
concept-1708	56	30	with	with	ADP
concept-1708	56	31	clump	clump	NOUN
concept-1708	56	32	size	size	NOUN
concept-1708	56	33	,	,	PUNCT
concept-1708	56	34	and	and	CCONJ
concept-1708	56	35	that	that	SCONJ
concept-1708	56	36	the	the	DET
concept-1708	56	37	entry	entry	NOUN
concept-1708	56	38	rate	rate	NOUN
concept-1708	56	39	of	of	ADP
concept-1708	56	40	clumps	clump	NOUN
concept-1708	56	41	depends	depend	VERB
concept-1708	56	42	on	on	ADP
concept-1708	56	43	size	size	NOUN
concept-1708	56	44	and	and	CCONJ
concept-1708	56	45	follows	follow	VERB
concept-1708	56	46	a	a	DET
concept-1708	56	47	decaying	decay	VERB
concept-1708	56	48	power	power	NOUN
concept-1708	56	49	-	-	PUNCT
concept-1708	56	50	law	law	NOUN
concept-1708	56	51	.	.	PUNCT
concept-1708	57	1	they	they	PRON
concept-1708	57	2	defined	define	VERB
concept-1708	57	3	their	their	PRON
concept-1708	57	4	overall	overall	ADJ
concept-1708	57	5	objective	objective	NOUN
concept-1708	57	6	as	as	ADP
concept-1708	57	7	being	be	AUX
concept-1708	57	8	to	to	PART
concept-1708	57	9	“	"	PUNCT
concept-1708	57	10	provide	provide	VERB
concept-1708	57	11	a	a	DET
concept-1708	57	12	framework	framework	NOUN
concept-1708	57	13	for	for	ADP
concept-1708	57	14	predicting	predict	VERB
concept-1708	57	15	the	the	DET
concept-1708	57	16	development	development	NOUN
concept-1708	57	17	of	of	ADP
concept-1708	57	18	metastatic	metastatic	ADJ
concept-1708	57	19	foci	focus	NOUN
concept-1708	57	20	from	from	ADP
concept-1708	57	21	clumps	clump	NOUN
concept-1708	57	22	in	in	ADP
concept-1708	57	23	the	the	DET
concept-1708	57	24	pulmonary	pulmonary	ADJ
concept-1708	57	25	vessels	vessel	NOUN
concept-1708	57	26	and	and	CCONJ
concept-1708	57	27	the	the	DET
concept-1708	57	28	probability	probability	NOUN
concept-1708	57	29	of	of	ADP
concept-1708	57	30	no	no	DET
concept-1708	57	31	metastatic	metastatic	ADJ
concept-1708	57	32	foci	focus	NOUN
concept-1708	57	33	existing	exist	VERB
concept-1708	57	34	after	after	ADP
concept-1708	57	35	tumor	tumor	NOUN
concept-1708	57	36	initiation	initiation	NOUN
concept-1708	57	37	”	"	PUNCT
concept-1708	57	38	(	(	PUNCT
concept-1708	57	39	14	14	NUM
concept-1708	57	40	)	)	PUNCT
concept-1708	57	41	.	.	PUNCT
concept-1708	58	1	liotta	liotta	PROPN
concept-1708	58	2	et	et	PROPN
concept-1708	58	3	al	al	PROPN
concept-1708	58	4	.	.	PROPN
concept-1708	58	5	developed	develop	VERB
concept-1708	58	6	a	a	DET
concept-1708	58	7	two	two	NUM
concept-1708	58	8	-	-	PUNCT
concept-1708	58	9	dimensional	dimensional	ADJ
concept-1708	58	10	markov	markov	NOUN
concept-1708	58	11	process	process	NOUN
concept-1708	58	12	to	to	PART
concept-1708	58	13	determine	determine	VERB
concept-1708	58	14	the	the	DET
concept-1708	58	15	probability	probability	NOUN
concept-1708	58	16	of	of	ADP
concept-1708	58	17	the	the	DET
concept-1708	58	18	population	population	NOUN
concept-1708	58	19	sizes	size	NOUN
concept-1708	58	20	of	of	ADP
concept-1708	58	21	metastatic	metastatic	ADJ
concept-1708	58	22	foci	focus	NOUN
concept-1708	58	23	and	and	CCONJ
concept-1708	58	24	tumor	tumor	NOUN
concept-1708	58	25	cell	cell	NOUN
concept-1708	58	26	clumps	clump	NOUN
concept-1708	58	27	at	at	ADP
concept-1708	58	28	any	any	DET
concept-1708	58	29	time	time	NOUN
concept-1708	58	30	(	(	PUNCT
concept-1708	58	31	14	14	NUM
concept-1708	58	32	)	)	PUNCT
concept-1708	58	33	.	.	PUNCT
concept-1708	59	1	the	the	DET
concept-1708	59	2	first	first	ADJ
concept-1708	59	3	state	state	NOUN
concept-1708	59	4	involves	involve	VERB
concept-1708	59	5	cancer	cancer	NOUN
concept-1708	59	6	cells	cell	NOUN
concept-1708	59	7	penetrating	penetrate	VERB
concept-1708	59	8	the	the	DET
concept-1708	59	9	tumor	tumor	NOUN
concept-1708	59	10	wall	wall	NOUN
concept-1708	59	11	to	to	PART
concept-1708	59	12	become	become	VERB
concept-1708	59	13	exposed	expose	VERB
concept-1708	59	14	on	on	ADP
concept-1708	59	15	the	the	DET
concept-1708	59	16	inner	inner	ADJ
concept-1708	59	17	vessel	vessel	NOUN
concept-1708	59	18	surface	surface	NOUN
concept-1708	59	19	.	.	PUNCT
concept-1708	60	1	once	once	SCONJ
concept-1708	60	2	they	they	PRON
concept-1708	60	3	are	be	AUX
concept-1708	60	4	exposed	expose	VERB
concept-1708	60	5	,	,	PUNCT
concept-1708	60	6	the	the	DET
concept-1708	60	7	tumor	tumor	NOUN
concept-1708	60	8	cells	cell	NOUN
concept-1708	60	9	enter	enter	VERB
concept-1708	60	10	the	the	DET
concept-1708	60	11	blood	blood	NOUN
concept-1708	60	12	circulation	circulation	NOUN
concept-1708	60	13	in	in	ADP
concept-1708	60	14	clumps	clump	NOUN
concept-1708	60	15	of	of	ADP
concept-1708	60	16	varying	vary	VERB
concept-1708	60	17	size	size	NOUN
concept-1708	60	18	.	.	PUNCT
concept-1708	61	1	liotta	liotta	PROPN
concept-1708	61	2	et	et	PROPN
concept-1708	61	3	al	al	PROPN
concept-1708	61	4	.	.	PROPN
concept-1708	62	1	determined	determine	VERB
concept-1708	62	2	that	that	SCONJ
concept-1708	62	3	clumps	clump	NOUN
concept-1708	62	4	of	of	ADP
concept-1708	62	5	four	four	NUM
concept-1708	62	6	cells	cell	NOUN
concept-1708	62	7	or	or	CCONJ
concept-1708	62	8	greater	great	ADJ
concept-1708	62	9	would	would	AUX
concept-1708	62	10	progress	progress	VERB
concept-1708	62	11	in	in	ADP
concept-1708	62	12	the	the	DET
concept-1708	62	13	pulmonary	pulmonary	ADJ
concept-1708	62	14	blood	blood	NOUN
concept-1708	62	15	vessels	vessel	NOUN
concept-1708	62	16	,	,	PUNCT
concept-1708	62	17	but	but	CCONJ
concept-1708	62	18	that	that	SCONJ
concept-1708	62	19	smaller	small	ADJ
concept-1708	62	20	clumps	clump	NOUN
concept-1708	62	21	and	and	CCONJ
concept-1708	62	22	singular	singular	ADJ
concept-1708	62	23	cells	cell	NOUN
concept-1708	62	24	would	would	AUX
concept-1708	62	25	adhere	adhere	VERB
concept-1708	62	26	to	to	ADP
concept-1708	62	27	the	the	DET
concept-1708	62	28	inner	inner	ADJ
concept-1708	62	29	layer	layer	NOUN
concept-1708	62	30	of	of	ADP
concept-1708	62	31	the	the	DET
concept-1708	62	32	vessel	vessel	NOUN
concept-1708	62	33	and	and	CCONJ
concept-1708	62	34	stop	stop	VERB
concept-1708	62	35	moving	move	VERB
concept-1708	62	36	.	.	PUNCT
concept-1708	63	1	they	they	PRON
concept-1708	63	2	established	establish	VERB
concept-1708	63	3	that	that	DET
concept-1708	63	4	death	death	NOUN
concept-1708	63	5	of	of	ADP
concept-1708	63	6	cell	cell	NOUN
concept-1708	63	7	clumps	clump	NOUN
concept-1708	63	8	could	could	AUX
concept-1708	63	9	occur	occur	VERB
concept-1708	63	10	due	due	ADP
concept-1708	63	11	to	to	ADP
concept-1708	63	12	a	a	DET
concept-1708	63	13	variety	variety	NOUN
concept-1708	63	14	of	of	ADP
concept-1708	63	15	causes	cause	NOUN
concept-1708	63	16	and	and	CCONJ
concept-1708	63	17	created	create	VERB
concept-1708	63	18	a	a	DET
concept-1708	63	19	probability	probability	NOUN
concept-1708	63	20	equation	equation	NOUN
concept-1708	63	21	to	to	PART
concept-1708	63	22	account	account	VERB
concept-1708	63	23	for	for	ADP
concept-1708	63	24	these	these	DET
concept-1708	63	25	reasons	reason	NOUN
concept-1708	63	26	,	,	PUNCT
concept-1708	63	27	which	which	PRON
concept-1708	63	28	  	  	SPACE
concept-1708	63	29	included	include	VERB
concept-1708	63	30	“	"	PUNCT
concept-1708	63	31	destruction	destruction	NOUN
concept-1708	63	32	by	by	ADP
concept-1708	63	33	host	host	NOUN
concept-1708	63	34	defense	defense	NOUN
concept-1708	63	35	,	,	PUNCT
concept-1708	63	36	removal	removal	NOUN
concept-1708	63	37	from	from	ADP
concept-1708	63	38	the	the	DET
concept-1708	63	39	pulmonary	pulmonary	ADJ
concept-1708	63	40	vessels	vessel	NOUN
concept-1708	63	41	,	,	PUNCT
concept-1708	63	42	aging	age	VERB
concept-1708	63	43	factors	factor	NOUN
concept-1708	63	44	,	,	PUNCT
concept-1708	63	45	or	or	CCONJ
concept-1708	63	46	sheer	sheer	ADJ
concept-1708	63	47	stress	stress	NOUN
concept-1708	63	48	damage	damage	NOUN
concept-1708	63	49	”	"	PUNCT
concept-1708	63	50	(	(	PUNCT
concept-1708	63	51	14	14	NUM
concept-1708	63	52	)	)	PUNCT
concept-1708	63	53	.	.	PUNCT
concept-1708	64	1	this	this	DET
concept-1708	64	2	equation	equation	NOUN
concept-1708	64	3	did	do	AUX
concept-1708	64	4	not	not	PART
concept-1708	64	5	account	account	VERB
concept-1708	64	6	for	for	ADP
concept-1708	64	7	the	the	DET
concept-1708	64	8	loss	loss	NOUN
concept-1708	64	9	of	of	ADP
concept-1708	64	10	tumor	tumor	NOUN
concept-1708	64	11	cell	cell	NOUN
concept-1708	64	12	clumps	clump	NOUN
concept-1708	64	13	that	that	PRON
concept-1708	64	14	had	have	AUX
concept-1708	64	15	transformed	transform	VERB
concept-1708	64	16	into	into	ADP
concept-1708	64	17	metastatic	metastatic	ADJ
concept-1708	64	18	foci	focus	NOUN
concept-1708	64	19	;	;	PUNCT
concept-1708	64	20	they	they	PRON
concept-1708	64	21	instead	instead	ADV
concept-1708	64	22	established	establish	VERB
concept-1708	64	23	a	a	DET
concept-1708	64	24	separate	separate	ADJ
concept-1708	64	25	equation	equation	NOUN
concept-1708	64	26	for	for	ADP
concept-1708	64	27	the	the	DET
concept-1708	64	28	formation	formation	NOUN
concept-1708	64	29	rate	rate	NOUN
concept-1708	64	30	of	of	ADP
concept-1708	64	31	metastatic	metastatic	ADJ
concept-1708	64	32	foci	focus	NOUN
concept-1708	64	33	from	from	ADP
concept-1708	64	34	a	a	DET
concept-1708	64	35	tumor	tumor	NOUN
concept-1708	64	36	clump	clump	NOUN
concept-1708	64	37	.	.	PUNCT
concept-1708	65	1	they	they	PRON
concept-1708	65	2	found	find	VERB
concept-1708	65	3	that	that	SCONJ
concept-1708	65	4	there	there	PRON
concept-1708	65	5	is	be	VERB
concept-1708	65	6	a	a	DET
concept-1708	65	7	direct	direct	ADJ
concept-1708	65	8	correlation	correlation	NOUN
concept-1708	65	9	between	between	ADP
concept-1708	65	10	the	the	DET
concept-1708	65	11	number	number	NOUN
concept-1708	65	12	of	of	ADP
concept-1708	65	13	cancer	cancer	NOUN
concept-1708	65	14	cells	cell	NOUN
concept-1708	65	15	that	that	PRON
concept-1708	65	16	enter	enter	VERB
concept-1708	65	17	the	the	DET
concept-1708	65	18	bloodstream	bloodstream	NOUN
concept-1708	65	19	and	and	CCONJ
concept-1708	65	20	the	the	DET
concept-1708	65	21	subsequent	subsequent	ADJ
concept-1708	65	22	number	number	NOUN
concept-1708	65	23	of	of	ADP
concept-1708	65	24	pulmonary	pulmonary	ADJ
concept-1708	65	25	metastases	metastasis	NOUN
concept-1708	65	26	.	.	PUNCT
concept-1708	66	1	they	they	PRON
concept-1708	66	2	also	also	ADV
concept-1708	66	3	determined	determine	VERB
concept-1708	66	4	that	that	SCONJ
concept-1708	66	5	if	if	SCONJ
concept-1708	66	6	cell	cell	NOUN
concept-1708	66	7	clumps	clump	NOUN
concept-1708	66	8	are	be	AUX
concept-1708	66	9	larger	large	ADJ
concept-1708	66	10	,	,	PUNCT
concept-1708	66	11	there	there	PRON
concept-1708	66	12	is	be	VERB
concept-1708	66	13	a	a	DET
concept-1708	66	14	greater	great	ADJ
concept-1708	66	15	number	number	NOUN
concept-1708	66	16	of	of	ADP
concept-1708	66	17	resulting	result	VERB
concept-1708	66	18	metastases	metastasis	NOUN
concept-1708	66	19	,	,	PUNCT
concept-1708	66	20	even	even	ADV
concept-1708	66	21	if	if	SCONJ
concept-1708	66	22	the	the	DET
concept-1708	66	23	overall	overall	ADJ
concept-1708	66	24	number	number	NOUN
concept-1708	66	25	of	of	ADP
concept-1708	66	26	cells	cell	NOUN
concept-1708	66	27	entering	enter	VERB
concept-1708	66	28	the	the	DET
concept-1708	66	29	circulatory	circulatory	ADJ
concept-1708	66	30	system	system	NOUN
concept-1708	66	31	is	be	AUX
concept-1708	66	32	the	the	DET
concept-1708	66	33	same	same	ADJ
concept-1708	66	34	.	.	PUNCT
concept-1708	67	1	they	they	PRON
concept-1708	67	2	noted	note	VERB
concept-1708	67	3	that	that	SCONJ
concept-1708	67	4	in	in	ADP
concept-1708	67	5	cancer	cancer	NOUN
concept-1708	67	6	cases	case	NOUN
concept-1708	67	7	,	,	PUNCT
concept-1708	67	8	their	their	PRON
concept-1708	67	9	model	model	NOUN
concept-1708	67	10	for	for	ADP
concept-1708	67	11	the	the	DET
concept-1708	67	12	survival	survival	NOUN
concept-1708	67	13	of	of	ADP
concept-1708	67	14	cancer	cancer	NOUN
concept-1708	67	15	cells	cell	NOUN
concept-1708	67	16	in	in	ADP
concept-1708	67	17	the	the	DET
concept-1708	67	18	bloodstream	bloodstream	NOUN
concept-1708	67	19	might	might	AUX
concept-1708	67	20	have	have	VERB
concept-1708	67	21	significance	significance	NOUN
concept-1708	67	22	in	in	ADP
concept-1708	67	23	the	the	DET
concept-1708	67	24	prognostic	prognostic	ADJ
concept-1708	67	25	process	process	NOUN
concept-1708	67	26	of	of	ADP
concept-1708	67	27	a	a	DET
concept-1708	67	28	metastatic	metastatic	ADJ
concept-1708	67	29	cancer	cancer	NOUN
concept-1708	67	30	(	(	PUNCT
concept-1708	67	31	14	14	NUM
concept-1708	67	32	)	)	PUNCT
concept-1708	67	33	.	.	PUNCT
concept-1708	68	1	divoli	divoli	ADP
concept-1708	68	2	et	et	PROPN
concept-1708	68	3	al	al	PROPN
concept-1708	68	4	.	.	PROPN
concept-1708	69	1	(	(	PUNCT
concept-1708	69	2	5	5	X
concept-1708	69	3	)	)	PUNCT
concept-1708	69	4	also	also	ADV
concept-1708	69	5	utilized	utilize	VERB
concept-1708	69	6	a	a	DET
concept-1708	69	7	markov	markov	NOUN
concept-1708	69	8	approach	approach	NOUN
concept-1708	69	9	,	,	PUNCT
concept-1708	69	10	but	but	CCONJ
concept-1708	69	11	instead	instead	ADV
concept-1708	69	12	of	of	ADP
concept-1708	69	13	basing	base	VERB
concept-1708	69	14	their	their	PRON
concept-1708	69	15	study	study	NOUN
concept-1708	69	16	solely	solely	ADV
concept-1708	69	17	on	on	ADP
concept-1708	69	18	raw	raw	ADJ
concept-1708	69	19	data	datum	NOUN
concept-1708	69	20	or	or	CCONJ
concept-1708	69	21	experiments	experiment	NOUN
concept-1708	69	22	,	,	PUNCT
concept-1708	69	23	they	they	PRON
concept-1708	69	24	also	also	ADV
concept-1708	69	25	interviewed	interview	VERB
concept-1708	69	26	28	28	NUM
concept-1708	69	27	experts	expert	NOUN
concept-1708	69	28	in	in	ADP
concept-1708	69	29	different	different	ADJ
concept-1708	69	30	medical	medical	ADJ
concept-1708	69	31	disciplines	discipline	NOUN
concept-1708	69	32	(	(	PUNCT
concept-1708	69	33	breast	breast	NOUN
concept-1708	69	34	,	,	PUNCT
concept-1708	69	35	prostate	prostate	NOUN
concept-1708	69	36	,	,	PUNCT
concept-1708	69	37	gastrointestinal	gastrointestinal	ADJ
concept-1708	69	38	,	,	PUNCT
concept-1708	69	39	genetics	genetic	NOUN
concept-1708	69	40	,	,	PUNCT
concept-1708	69	41	etc	etc	X
concept-1708	69	42	.	.	X
concept-1708	69	43	)	)	PUNCT
concept-1708	69	44	.	.	PUNCT
concept-1708	70	1	in	in	ADP
concept-1708	70	2	these	these	DET
concept-1708	70	3	interviews	interview	NOUN
concept-1708	70	4	,	,	PUNCT
concept-1708	70	5	they	they	PRON
concept-1708	70	6	requested	request	VERB
concept-1708	70	7	a	a	DET
concept-1708	70	8	personal	personal	ADJ
concept-1708	70	9	definition	definition	NOUN
concept-1708	70	10	of	of	ADP
concept-1708	70	11	metastasis	metastasis	NOUN
concept-1708	70	12	from	from	ADP
concept-1708	70	13	each	each	DET
concept-1708	70	14	interviewee	interviewee	NOUN
concept-1708	70	15	and	and	CCONJ
concept-1708	70	16	attempted	attempt	VERB
concept-1708	70	17	to	to	PART
concept-1708	70	18	gain	gain	VERB
concept-1708	70	19	insight	insight	NOUN
concept-1708	70	20	on	on	ADP
concept-1708	70	21	the	the	DET
concept-1708	70	22	experts	expert	NOUN
concept-1708	70	23	’	’	PART
concept-1708	70	24	answers	answer	NOUN
concept-1708	70	25	to	to	ADP
concept-1708	70	26	key	key	ADJ
concept-1708	70	27	questions	question	NOUN
concept-1708	70	28	:	:	PUNCT
concept-1708	70	29	“	"	PUNCT
concept-1708	70	30	when	when	SCONJ
concept-1708	70	31	do	do	AUX
concept-1708	70	32	cells	cell	NOUN
concept-1708	70	33	acquire	acquire	VERB
concept-1708	70	34	metastatic	metastatic	ADJ
concept-1708	70	35	abilities	ability	NOUN
concept-1708	70	36	?	?	PUNCT
concept-1708	71	1	what	what	PRON
concept-1708	71	2	is	be	AUX
concept-1708	71	3	the	the	DET
concept-1708	71	4	basis	basis	NOUN
concept-1708	71	5	and	and	CCONJ
concept-1708	71	6	importance	importance	NOUN
concept-1708	71	7	of	of	ADP
concept-1708	71	8	tropism	tropism	NOUN
concept-1708	71	9	[	[	X
concept-1708	71	10	‘	'	PUNCT
concept-1708	71	11	an	an	DET
concept-1708	71	12	involuntary	involuntary	ADJ
concept-1708	71	13	orienting	orienting	ADJ
concept-1708	71	14	response	response	NOUN
concept-1708	71	15	;	;	PUNCT
concept-1708	71	16	positive	positive	ADJ
concept-1708	71	17	or	or	CCONJ
concept-1708	71	18	negative	negative	ADJ
concept-1708	71	19	reaction	reaction	NOUN
concept-1708	71	20	to	to	ADP
concept-1708	71	21	a	a	DET
concept-1708	71	22	stimulus	stimulus	ADJ
concept-1708	71	23	source	source	NOUN
concept-1708	71	24	’	'	PUNCT
concept-1708	71	25	(	(	PUNCT
concept-1708	71	26	15	15	NUM
concept-1708	71	27	)	)	PUNCT
concept-1708	71	28	]	]	PUNCT
concept-1708	71	29	?	?	PUNCT
concept-1708	72	1	what	what	PRON
concept-1708	72	2	(	(	PUNCT
concept-1708	72	3	if	if	SCONJ
concept-1708	72	4	any	any	PRON
concept-1708	72	5	)	)	PUNCT
concept-1708	72	6	is	be	AUX
concept-1708	72	7	the	the	DET
concept-1708	72	8	relationship	relationship	NOUN
concept-1708	72	9	between	between	ADP
concept-1708	72	10	metastasis	metastasis	NOUN
concept-1708	72	11	,	,	PUNCT
concept-1708	72	12	development	development	NOUN
concept-1708	72	13	and	and	CCONJ
concept-1708	72	14	evolution	evolution	NOUN
concept-1708	72	15	?	?	PUNCT
concept-1708	72	16	”	"	PUNCT
concept-1708	73	1	(	(	PUNCT
concept-1708	73	2	5	5	NUM
concept-1708	73	3	)	)	PUNCT
concept-1708	73	4	.	.	PUNCT
concept-1708	74	1	they	they	PRON
concept-1708	74	2	analyzed	analyze	VERB
concept-1708	74	3	the	the	DET
concept-1708	74	4	results	result	NOUN
concept-1708	74	5	in	in	ADP
concept-1708	74	6	two	two	NUM
concept-1708	74	7	ways	way	NOUN
concept-1708	74	8	.	.	PUNCT
concept-1708	75	1	first	first	ADV
concept-1708	75	2	,	,	PUNCT
concept-1708	75	3	they	they	PRON
concept-1708	75	4	used	use	VERB
concept-1708	75	5	a	a	DET
concept-1708	75	6	chi	chi	ADV
concept-1708	75	7	-	-	PUNCT
concept-1708	75	8	squared	square	VERB
concept-1708	75	9	statistic	statistic	NOUN
concept-1708	75	10	to	to	PART
concept-1708	75	11	determine	determine	VERB
concept-1708	75	12	disparities	disparity	NOUN
concept-1708	75	13	in	in	ADP
concept-1708	75	14	answers	answer	NOUN
concept-1708	75	15	across	across	ADP
concept-1708	75	16	the	the	DET
concept-1708	75	17	question	question	NOUN
concept-1708	75	18	topics	topic	NOUN
concept-1708	75	19	and	and	CCONJ
concept-1708	75	20	the	the	DET
concept-1708	75	21	difference	difference	NOUN
concept-1708	75	22	in	in	ADP
concept-1708	75	23	interest	interest	NOUN
concept-1708	75	24	of	of	ADP
concept-1708	75	25	each	each	DET
concept-1708	75	26	topic	topic	NOUN
concept-1708	75	27	between	between	ADP
concept-1708	75	28	the	the	DET
concept-1708	75	29	expert	expert	ADJ
concept-1708	75	30	groups	group	NOUN
concept-1708	75	31	.	.	PUNCT
concept-1708	76	1	then	then	ADV
concept-1708	76	2	they	they	PRON
concept-1708	76	3	quantified	quantify	VERB
concept-1708	76	4	similarity	similarity	NOUN
concept-1708	76	5	and	and	CCONJ
concept-1708	76	6	dissimilarity	dissimilarity	NOUN
concept-1708	76	7	between	between	ADP
concept-1708	76	8	pairs	pair	NOUN
concept-1708	76	9	of	of	ADP
concept-1708	76	10	experts	expert	NOUN
concept-1708	76	11	by	by	ADP
concept-1708	76	12	employing	employ	VERB
concept-1708	76	13	a	a	DET
concept-1708	76	14	metric	metric	NOUN
concept-1708	76	15	that	that	PRON
concept-1708	76	16	corresponded	correspond	VERB
concept-1708	76	17	each	each	DET
concept-1708	76	18	stage	stage	NOUN
concept-1708	76	19	of	of	ADP
concept-1708	76	20	metastasis	metastasis	NOUN
concept-1708	76	21	with	with	ADP
concept-1708	76	22	a	a	DET
concept-1708	76	23	letter	letter	NOUN
concept-1708	76	24	to	to	PART
concept-1708	76	25	determine	determine	VERB
concept-1708	76	26	each	each	DET
concept-1708	76	27	expert	expert	NOUN
concept-1708	76	28	’s	’s	PART
concept-1708	76	29	thoughts	thought	NOUN
concept-1708	76	30	on	on	ADP
concept-1708	76	31	the	the	DET
concept-1708	76	32	chain	chain	NOUN
concept-1708	76	33	of	of	ADP
concept-1708	76	34	metastasis	metastasis	NOUN
concept-1708	76	35	and	and	CCONJ
concept-1708	76	36	then	then	ADV
concept-1708	76	37	comparing	compare	VERB
concept-1708	76	38	his	his	PRON
concept-1708	76	39	or	or	CCONJ
concept-1708	76	40	her	her	PRON
concept-1708	76	41	chain	chain	NOUN
concept-1708	76	42	with	with	ADP
concept-1708	76	43	another	another	DET
concept-1708	76	44	expert	expert	NOUN
concept-1708	76	45	to	to	PART
concept-1708	76	46	determine	determine	VERB
concept-1708	76	47	the	the	DET
concept-1708	76	48	level	level	NOUN
concept-1708	76	49	of	of	ADP
concept-1708	76	50	similarity	similarity	NOUN
concept-1708	76	51	(	(	PUNCT
concept-1708	76	52	sij	sij	PROPN
concept-1708	76	53	)	)	PUNCT
concept-1708	76	54	or	or	CCONJ
concept-1708	76	55	dissimilarity	dissimilarity	NOUN
concept-1708	76	56	(	(	PUNCT
concept-1708	76	57	dij	dij	PROPN
concept-1708	76	58	)	)	PUNCT
concept-1708	76	59	.	.	PUNCT
concept-1708	77	1	they	they	PRON
concept-1708	77	2	defined	define	VERB
concept-1708	77	3	similarity	similarity	NOUN
concept-1708	77	4	as	as	ADP
concept-1708	77	5	“	"	PUNCT
concept-1708	77	6	twice	twice	DET
concept-1708	77	7	the	the	DET
concept-1708	77	8	number	number	NOUN
concept-1708	77	9	of	of	ADP
concept-1708	77	10	ordered	order	VERB
concept-1708	77	11	pairs	pair	NOUN
concept-1708	77	12	common	common	ADJ
concept-1708	77	13	to	to	ADP
concept-1708	77	14	the	the	DET
concept-1708	77	15	two	two	NUM
concept-1708	77	16	sets	set	NOUN
concept-1708	77	17	”	"	PUNCT
concept-1708	77	18	where	where	SCONJ
concept-1708	77	19	sij	sij	PROPN
concept-1708	77	20	=	=	SYM
concept-1708	77	21	sii	sii	PROPN
concept-1708	77	22	+	+	PROPN
concept-1708	77	23	sjj	sjj	PROPN
concept-1708	77	24	(	(	PUNCT
concept-1708	77	25	15	15	NUM
concept-1708	77	26	)	)	PUNCT
concept-1708	77	27	.	.	PUNCT
concept-1708	78	1	they	they	PRON
concept-1708	78	2	defined	define	VERB
concept-1708	78	3	dissimilarity	dissimilarity	NOUN
concept-1708	78	4	as	as	ADP
concept-1708	78	5	“	"	PUNCT
concept-1708	78	6	similarity	similarity	NOUN
concept-1708	78	7	minus	minus	CCONJ
concept-1708	78	8	the	the	DET
concept-1708	78	9	sum	sum	NOUN
concept-1708	78	10	of	of	ADP
concept-1708	78	11	all	all	DET
concept-1708	78	12	unmatched	unmatched	ADJ
concept-1708	78	13	pairs	pair	NOUN
concept-1708	78	14	of	of	ADP
concept-1708	78	15	event	event	NOUN
concept-1708	78	16	from	from	ADP
concept-1708	78	17	the	the	DET
concept-1708	78	18	two	two	NUM
concept-1708	78	19	sets	set	NOUN
concept-1708	78	20	,	,	PUNCT
concept-1708	78	21	”	"	PUNCT
concept-1708	78	22	where	where	SCONJ
concept-1708	78	23	dij	dij	PROPN
concept-1708	78	24	=	=	SYM
concept-1708	78	25	sii	sii	PROPN
concept-1708	78	26	+	+	CCONJ
concept-1708	78	27	sjj	sjj	PROPN
concept-1708	78	28	–	–	PUNCT
concept-1708	78	29	2	2	NUM
concept-1708	78	30	sij	sij	NOUN
concept-1708	78	31	.	.	PUNCT
concept-1708	79	1	they	they	PRON
concept-1708	79	2	were	be	AUX
concept-1708	79	3	able	able	ADJ
concept-1708	79	4	to	to	PART
concept-1708	79	5	create	create	VERB
concept-1708	79	6	a	a	DET
concept-1708	79	7	set	set	NOUN
concept-1708	79	8	of	of	ADP
concept-1708	79	9	quantitative	quantitative	ADJ
concept-1708	79	10	data	datum	NOUN
concept-1708	79	11	to	to	PART
concept-1708	79	12	use	use	VERB
concept-1708	79	13	in	in	ADP
concept-1708	79	14	a	a	DET
concept-1708	79	15	markov	markov	NOUN
concept-1708	79	16	chain	chain	NOUN
concept-1708	79	17	process	process	NOUN
concept-1708	79	18	to	to	PART
concept-1708	79	19	determine	determine	VERB
concept-1708	79	20	each	each	DET
concept-1708	79	21	expert	expert	NOUN
concept-1708	79	22	’s	’s	PART
concept-1708	79	23	opinion	opinion	NOUN
concept-1708	79	24	of	of	ADP
concept-1708	79	25	the	the	DET
concept-1708	79	26	sequence	sequence	NOUN
concept-1708	79	27	of	of	ADP
concept-1708	79	28	events	event	NOUN
concept-1708	79	29	in	in	ADP
concept-1708	79	30	metastasis	metastasis	NOUN
concept-1708	79	31	and	and	CCONJ
concept-1708	79	32	create	create	VERB
concept-1708	79	33	a	a	DET
concept-1708	79	34	standard	standard	NOUN
concept-1708	79	35	to	to	PART
concept-1708	79	36	measure	measure	VERB
concept-1708	79	37	future	future	ADJ
concept-1708	79	38	experimental	experimental	ADJ
concept-1708	79	39	and	and	CCONJ
concept-1708	79	40	observational	observational	ADJ
concept-1708	79	41	data	datum	NOUN
concept-1708	79	42	against	against	ADP
concept-1708	79	43	(	(	PUNCT
concept-1708	79	44	15	15	NUM
concept-1708	79	45	)	)	PUNCT
concept-1708	79	46	.	.	PUNCT
concept-1708	80	1	to	to	PART
concept-1708	80	2	begin	begin	VERB
concept-1708	80	3	their	their	PRON
concept-1708	80	4	markov	markov	NOUN
concept-1708	80	5	calculations	calculation	NOUN
concept-1708	80	6	,	,	PUNCT
concept-1708	80	7	they	they	PRON
concept-1708	80	8	created	create	VERB
concept-1708	80	9	a	a	DET
concept-1708	80	10	transitional	transitional	ADJ
concept-1708	80	11	matrix	matrix	NOUN
concept-1708	80	12	p	p	PUNCT
concept-1708	80	13	to	to	PART
concept-1708	80	14	represent	represent	VERB
concept-1708	80	15	each	each	DET
concept-1708	80	16	expert	expert	NOUN
concept-1708	80	17	’s	’s	PART
concept-1708	80	18	proposed	propose	VERB
concept-1708	80	19	path	path	NOUN
concept-1708	80	20	of	of	ADP
concept-1708	80	21	metastasis	metastasis	NOUN
concept-1708	80	22	with	with	ADP
concept-1708	80	23	each	each	DET
concept-1708	80	24	entry	entry	NOUN
concept-1708	80	25	of	of	ADP
concept-1708	80	26	the	the	DET
concept-1708	80	27	matrix	matrix	NOUN
concept-1708	80	28	pij	pij	NOUN
concept-1708	80	29	representing	represent	VERB
concept-1708	80	30	the	the	DET
concept-1708	80	31	probability	probability	NOUN
concept-1708	80	32	of	of	ADP
concept-1708	80	33	transition	transition	NOUN
concept-1708	80	34	from	from	ADP
concept-1708	80	35	state	state	NOUN
concept-1708	80	36	i	i	PRON
concept-1708	80	37	to	to	ADP
concept-1708	80	38	state	state	PROPN
concept-1708	80	39	j.	j.	PROPN
concept-1708	80	40	they	they	PRON
concept-1708	80	41	assumed	assume	VERB
concept-1708	80	42	each	each	DET
concept-1708	80	43	metastatic	metastatic	ADJ
concept-1708	80	44	stage	stage	NOUN
concept-1708	80	45	would	would	AUX
concept-1708	80	46	depend	depend	VERB
concept-1708	80	47	only	only	ADV
concept-1708	80	48	on	on	ADP
concept-1708	80	49	the	the	DET
concept-1708	80	50	one	one	NUM
concept-1708	80	51	directly	directly	ADV
concept-1708	80	52	  	  	SPACE
concept-1708	80	53	before	before	ADV
concept-1708	80	54	,	,	PUNCT
concept-1708	80	55	that	that	DET
concept-1708	80	56	transitional	transitional	ADJ
concept-1708	80	57	probabilities	probability	NOUN
concept-1708	80	58	from	from	ADP
concept-1708	80	59	one	one	NUM
concept-1708	80	60	state	state	NOUN
concept-1708	80	61	to	to	ADP
concept-1708	80	62	another	another	PRON
concept-1708	80	63	would	would	AUX
concept-1708	80	64	not	not	PART
concept-1708	80	65	change	change	VERB
concept-1708	80	66	across	across	ADP
concept-1708	80	67	the	the	DET
concept-1708	80	68	sequence	sequence	NOUN
concept-1708	80	69	,	,	PUNCT
concept-1708	80	70	and	and	CCONJ
concept-1708	80	71	that	that	SCONJ
concept-1708	80	72	the	the	DET
concept-1708	80	73	cancer	cancer	NOUN
concept-1708	80	74	would	would	AUX
concept-1708	80	75	not	not	PART
concept-1708	80	76	transition	transition	VERB
concept-1708	80	77	to	to	ADP
concept-1708	80	78	itself	itself	PRON
concept-1708	80	79	.	.	PUNCT
concept-1708	81	1	they	they	PRON
concept-1708	81	2	defined	define	VERB
concept-1708	81	3	n=28	n=28	NOUN
concept-1708	81	4	possible	possible	ADJ
concept-1708	81	5	states	state	NOUN
concept-1708	81	6	within	within	ADP
concept-1708	81	7	the	the	DET
concept-1708	81	8	metastatic	metastatic	ADJ
concept-1708	81	9	path	path	NOUN
concept-1708	81	10	(	(	PUNCT
concept-1708	81	11	one	one	NUM
concept-1708	81	12	from	from	ADP
concept-1708	81	13	each	each	DET
concept-1708	81	14	expert	expert	NOUN
concept-1708	81	15	)	)	PUNCT
concept-1708	81	16	,	,	PUNCT
concept-1708	81	17	with	with	ADP
concept-1708	81	18	each	each	DET
concept-1708	81	19	path	path	NOUN
concept-1708	81	20	starting	start	VERB
concept-1708	81	21	at	at	ADP
concept-1708	81	22	a	a	DET
concept-1708	81	23	state	state	NOUN
concept-1708	81	24	s	s	NOUN
concept-1708	81	25	and	and	CCONJ
concept-1708	81	26	ending	end	VERB
concept-1708	81	27	at	at	ADP
concept-1708	81	28	a	a	DET
concept-1708	81	29	state	state	NOUN
concept-1708	81	30	e	e	NOUN
concept-1708	81	31	,	,	PUNCT
concept-1708	81	32	and	and	CCONJ
concept-1708	81	33	found	find	VERB
concept-1708	81	34	that	that	SCONJ
concept-1708	81	35	always	always	ADV
concept-1708	81	36	ending	end	VERB
concept-1708	81	37	the	the	DET
concept-1708	81	38	chain	chain	NOUN
concept-1708	81	39	at	at	ADP
concept-1708	81	40	stage	stage	NOUN
concept-1708	81	41	e	e	NOUN
concept-1708	81	42	results	result	VERB
concept-1708	81	43	in	in	ADP
concept-1708	81	44	a	a	DET
concept-1708	81	45	steady	steady	ADJ
concept-1708	81	46	state	state	NOUN
concept-1708	81	47	distribution	distribution	NOUN
concept-1708	81	48	vector	vector	NOUN
concept-1708	81	49	of	of	ADP
concept-1708	81	50	π	π	PROPN
concept-1708	81	51	=	=	SYM
concept-1708	81	52	(	(	PUNCT
concept-1708	81	53	0,0,	0,0,	NOUN
concept-1708	81	54	…	…	SYM
concept-1708	81	55	,1	,1	NOUN
concept-1708	81	56	)	)	PUNCT
concept-1708	81	57	defined	define	VERB
concept-1708	81	58	by	by	ADP
concept-1708	81	59	the	the	DET
concept-1708	81	60	distribution	distribution	NOUN
concept-1708	81	61	of	of	ADP
concept-1708	81	62	transition	transition	NOUN
concept-1708	81	63	probabilities	probability	NOUN
concept-1708	81	64	using	use	VERB
concept-1708	81	65	a	a	DET
concept-1708	81	66	dirichlet	dirichlet	NOUN
concept-1708	81	67	distribution	distribution	NOUN
concept-1708	81	68	:	:	PUNCT
concept-1708	81	69	{	{	PUNCT
concept-1708	81	70	𝜌!"}!!!;!!!;!!!,	𝜌!"}!!!;!!!;!!!,	NUM
concept-1708	81	71	…	…	SYM
concept-1708	81	72	!~dirichlet	!~dirichlet	NOUN
concept-1708	81	73	𝛼	𝛼	NOUN
concept-1708	81	74	𝑁	𝑁	NOUN
concept-1708	81	75	−	−	PROPN
concept-1708	81	76	2	2	NUM
concept-1708	81	77	,	,	PUNCT
concept-1708	81	78	…	…	PUNCT
concept-1708	81	79	,	,	PUNCT
concept-1708	81	80	𝛼	𝛼	X
concept-1708	81	81	𝑁	𝑁	NOUN
concept-1708	81	82	−	−	PROPN
concept-1708	81	83	2	2	NUM
concept-1708	81	84	.	.	PUNCT
concept-1708	82	1	𝑓	𝑓	DET
concept-1708	82	2	𝜌	𝜌	NOUN
concept-1708	82	3	!	!	PUNCT
concept-1708	82	4	!	!	PUNCT
concept-1708	82	5	,	,	PUNCT
concept-1708	82	6	…	…	PUNCT
concept-1708	82	7	,	,	PUNCT
concept-1708	82	8	𝜌	𝜌	X
concept-1708	82	9	!	!	PUNCT
concept-1708	82	10	"	"	PUNCT
concept-1708	82	11	𝛼	𝛼	X
concept-1708	82	12	=	=	SYM
concept-1708	82	13	γ(𝛼	γ(𝛼	X
concept-1708	82	14	)	)	PUNCT
concept-1708	82	15	γ	γ	PROPN
concept-1708	82	16	[	[	PUNCT
concept-1708	82	17	𝛼	𝛼	PRON
concept-1708	82	18	𝑁	𝑁	NOUN
concept-1708	82	19	−	−	PROPN
concept-1708	82	20	2	2	NUM
concept-1708	82	21	]	]	PUNCT
concept-1708	82	22	!	!	PUNCT
concept-1708	82	23	!	!	PUNCT
concept-1708	82	24	!	!	PUNCT
concept-1708	82	25	!	!	PUNCT
concept-1708	83	1	𝜌	𝜌	X
concept-1708	83	2	!	!	PUNCT
concept-1708	83	3	"	"	PUNCT
concept-1708	83	4	!	!	PUNCT
concept-1708	83	5	!	!	PUNCT
concept-1708	83	6	!	!	PUNCT
concept-1708	83	7	!	!	PUNCT
concept-1708	83	8	.	.	PUNCT
concept-1708	84	1	|	|	ADV
concept-1708	84	2	!	!	PUNCT
concept-1708	84	3	!	!	PUNCT
concept-1708	84	4	!	!	PUNCT
concept-1708	84	5	!	!	PUNCT
concept-1708	84	6	!	!	PUNCT
concept-1708	84	7	!	!	PUNCT
concept-1708	85	1	assuming	assume	VERB
concept-1708	85	2	α	α	PRON
concept-1708	85	3	≥	≥	NOUN
concept-1708	85	4	n-2	n-2	NUM
concept-1708	85	5	.	.	PUNCT
concept-1708	86	1	they	they	PRON
concept-1708	86	2	also	also	ADV
concept-1708	86	3	determined	determine	VERB
concept-1708	86	4	that	that	SCONJ
concept-1708	86	5	the	the	DET
concept-1708	86	6	posterior	posterior	ADJ
concept-1708	86	7	distribution	distribution	NOUN
concept-1708	86	8	for	for	ADP
concept-1708	86	9	pij	pij	NOUN
concept-1708	86	10	was	be	AUX
concept-1708	86	11	a	a	DET
concept-1708	86	12	conjugate	conjugate	ADJ
concept-1708	86	13	dirichlet	dirichlet	NOUN
concept-1708	86	14	distribution	distribution	NOUN
concept-1708	86	15	:	:	PUNCT
concept-1708	86	16	{	{	PUNCT
concept-1708	86	17	𝜌!"}!!!,	𝜌!"}!!!,	NOUN
concept-1708	86	18	…	…	PUNCT
concept-1708	86	19	,!~dirichlet	,!~dirichlet	PUNCT
concept-1708	86	20	𝛼	𝛼	INTJ
concept-1708	86	21	𝑁	𝑁	NOUN
concept-1708	86	22	−	−	PROPN
concept-1708	86	23	2	2	NUM
concept-1708	86	24	+	+	NOUN
concept-1708	86	25	𝑐	𝑐	NOUN
concept-1708	86	26	!	!	PUNCT
concept-1708	86	27	!	!	PUNCT
concept-1708	87	1	,	,	PUNCT
concept-1708	87	2	…	…	PUNCT
concept-1708	87	3	,	,	PUNCT
concept-1708	87	4	𝛼	𝛼	X
concept-1708	87	5	𝑁	𝑁	NOUN
concept-1708	87	6	−	−	PROPN
concept-1708	87	7	2	2	NUM
concept-1708	87	8	+	+	NOUN
concept-1708	87	9	𝑐	𝑐	NOUN
concept-1708	87	10	!	!	PUNCT
concept-1708	87	11	"	"	PUNCT
concept-1708	87	12	.	.	PUNCT
concept-1708	88	1	with	with	ADP
concept-1708	88	2	the	the	DET
concept-1708	88	3	posterior	posterior	ADJ
concept-1708	88	4	expectation	expectation	NOUN
concept-1708	88	5	estimate	estimate	NOUN
concept-1708	88	6	of	of	ADP
concept-1708	88	7	pij	pij	NOUN
concept-1708	88	8	given	give	VERB
concept-1708	88	9	by	by	ADP
concept-1708	88	10	𝜌	𝜌	ADP
concept-1708	88	11	!	!	PUNCT
concept-1708	88	12	"	"	PUNCT
concept-1708	88	13	!	!	PUNCT
concept-1708	88	14	"	"	PUNCT
concept-1708	89	1	=	=	SYM
concept-1708	89	2	𝑐	𝑐	X
concept-1708	89	3	!	!	PUNCT
concept-1708	89	4	"	"	PUNCT
concept-1708	90	1	+	+	CCONJ
concept-1708	90	2	𝛼	𝛼	VERB
concept-1708	90	3	𝑁	𝑁	NOUN
concept-1708	90	4	−	−	PROPN
concept-1708	90	5	2	2	NUM
concept-1708	90	6	𝐶	𝐶	PROPN
concept-1708	90	7	!	!	PUNCT
concept-1708	91	1	+	+	NUM
concept-1708	91	2	𝛼	𝛼	X
concept-1708	91	3	.	.	PUNCT
concept-1708	92	1	and	and	CCONJ
concept-1708	92	2	a	a	DET
concept-1708	92	3	maximum	maximum	NOUN
concept-1708	92	4	a	a	DET
concept-1708	92	5	posteriori	posteriori	NOUN
concept-1708	92	6	estimate	estimate	NOUN
concept-1708	92	7	of	of	ADP
concept-1708	92	8	pij	pij	NOUN
concept-1708	92	9	of	of	ADP
concept-1708	92	10	𝜌	𝜌	X
concept-1708	92	11	!	!	PUNCT
concept-1708	92	12	"	"	PUNCT
concept-1708	92	13	!	!	PUNCT
concept-1708	93	1	"	"	PUNCT
concept-1708	93	2	#	#	NOUN
concept-1708	93	3	=	=	SYM
concept-1708	93	4	𝑐	𝑐	NOUN
concept-1708	93	5	!	!	PUNCT
concept-1708	93	6	"	"	PUNCT
concept-1708	94	1	+	+	CCONJ
concept-1708	94	2	𝛼	𝛼	VERB
concept-1708	94	3	𝑁	𝑁	NOUN
concept-1708	94	4	−	−	PROPN
concept-1708	94	5	2	2	NUM
concept-1708	94	6	−	−	PROPN
concept-1708	94	7	1	1	NUM
concept-1708	94	8	𝐶	𝐶	PROPN
concept-1708	94	9	!	!	PUNCT
concept-1708	95	1	+	+	PUNCT
concept-1708	95	2	𝛼	𝛼	X
concept-1708	95	3	−	−	NOUN
concept-1708	95	4	𝑁	𝑁	PROPN
concept-1708	95	5	+	+	CCONJ
concept-1708	95	6	2	2	NUM
concept-1708	95	7	,	,	PUNCT
concept-1708	95	8	𝛼	𝛼	PRON
concept-1708	95	9	≥	≥	NOUN
concept-1708	96	1	𝑁	𝑁	PROPN
concept-1708	96	2	−	−	PROPN
concept-1708	96	3	2	2	NUM
concept-1708	96	4	,	,	PUNCT
concept-1708	96	5	𝑖	𝑖	PRON
concept-1708	96	6	≠	≠	PROPN
concept-1708	96	7	𝑗	𝑗	PROPN
concept-1708	96	8	,	,	PUNCT
concept-1708	96	9	𝑗	𝑗	INTJ
concept-1708	96	10	>	>	X
concept-1708	96	11	0	0	NUM
concept-1708	96	12	.	.	PUNCT
concept-1708	97	1	where	where	SCONJ
concept-1708	97	2	{	{	PUNCT
concept-1708	97	3	cij	cij	PROPN
concept-1708	97	4	}	}	PUNCT
concept-1708	97	5	is	be	AUX
concept-1708	97	6	the	the	DET
concept-1708	97	7	set	set	NOUN
concept-1708	97	8	of	of	ADP
concept-1708	97	9	observed	observed	ADJ
concept-1708	97	10	counts	count	NOUN
concept-1708	97	11	of	of	ADP
concept-1708	97	12	metastasis	metastasis	NOUN
concept-1708	97	13	transition	transition	NOUN
concept-1708	97	14	from	from	ADP
concept-1708	97	15	all	all	DET
concept-1708	97	16	experts	expert	NOUN
concept-1708	97	17	and	and	CCONJ
concept-1708	97	18	𝑐	𝑐	NOUN
concept-1708	97	19	!	!	PUNCT
concept-1708	97	20	"	"	PUNCT
concept-1708	98	1	=	=	PUNCT
concept-1708	98	2	𝐶	𝐶	PROPN
concept-1708	98	3	!	!	PUNCT
concept-1708	98	4	.	.	PUNCT
concept-1708	98	5	!	!	PUNCT
concept-1708	98	6	!	!	PUNCT
concept-1708	98	7	!	!	PUNCT
concept-1708	98	8	!	!	PUNCT
concept-1708	99	1	during	during	ADP
concept-1708	99	2	the	the	DET
concept-1708	99	3	interviews	interview	NOUN
concept-1708	99	4	,	,	PUNCT
concept-1708	99	5	divoli	divoli	ADP
concept-1708	99	6	et	et	PROPN
concept-1708	99	7	al	al	PROPN
concept-1708	99	8	.	.	PROPN
concept-1708	100	1	(	(	PUNCT
concept-1708	100	2	5	5	X
concept-1708	100	3	)	)	PUNCT
concept-1708	100	4	presented	present	VERB
concept-1708	100	5	each	each	DET
concept-1708	100	6	expert	expert	NOUN
concept-1708	100	7	with	with	ADP
concept-1708	100	8	a	a	DET
concept-1708	100	9	supposed	suppose	VERB
concept-1708	100	10	belief	belief	NOUN
concept-1708	100	11	of	of	ADP
concept-1708	100	12	the	the	DET
concept-1708	100	13	metastatic	metastatic	ADJ
concept-1708	100	14	process	process	NOUN
concept-1708	100	15	that	that	PRON
concept-1708	100	16	was	be	AUX
concept-1708	100	17	purposely	purposely	ADV
concept-1708	100	18	confused	confuse	VERB
concept-1708	100	19	,	,	PUNCT
concept-1708	100	20	expecting	expect	VERB
concept-1708	100	21	corrections	correction	NOUN
concept-1708	100	22	and	and	CCONJ
concept-1708	100	23	revisions	revision	NOUN
concept-1708	100	24	.	.	PUNCT
concept-1708	101	1	the	the	DET
concept-1708	101	2	experts	expert	NOUN
concept-1708	101	3	would	would	AUX
concept-1708	101	4	then	then	ADV
concept-1708	101	5	suggest	suggest	VERB
concept-1708	101	6	additions	addition	NOUN
concept-1708	101	7	,	,	PUNCT
concept-1708	101	8	deletions	deletion	NOUN
concept-1708	101	9	,	,	PUNCT
concept-1708	101	10	and	and	CCONJ
concept-1708	101	11	changes	change	NOUN
concept-1708	101	12	in	in	ADP
concept-1708	101	13	the	the	DET
concept-1708	101	14	sequencing	sequencing	NOUN
concept-1708	101	15	,	,	PUNCT
concept-1708	101	16	which	which	PRON
concept-1708	101	17	is	be	AUX
concept-1708	101	18	shown	show	VERB
concept-1708	101	19	in	in	ADP
concept-1708	101	20	the	the	DET
concept-1708	101	21	diagram	diagram	NOUN
concept-1708	101	22	below	below	ADV
concept-1708	101	23	.	.	PUNCT
concept-1708	102	1	overall	overall	ADV
concept-1708	102	2	,	,	PUNCT
concept-1708	102	3	all	all	DET
concept-1708	102	4	experts	expert	NOUN
concept-1708	102	5	agreed	agree	VERB
concept-1708	102	6	on	on	ADP
concept-1708	102	7	the	the	DET
concept-1708	102	8	significant	significant	ADJ
concept-1708	102	9	events	event	NOUN
concept-1708	102	10	  	  	SPACE
concept-1708	102	11	throughout	throughout	ADP
concept-1708	102	12	the	the	DET
concept-1708	102	13	process	process	NOUN
concept-1708	102	14	,	,	PUNCT
concept-1708	102	15	but	but	CCONJ
concept-1708	102	16	not	not	PART
concept-1708	102	17	on	on	ADP
concept-1708	102	18	the	the	DET
concept-1708	102	19	exact	exact	ADJ
concept-1708	102	20	path	path	NOUN
concept-1708	102	21	of	of	ADP
concept-1708	102	22	progression	progression	NOUN
concept-1708	102	23	.	.	PUNCT
concept-1708	103	1	they	they	PRON
concept-1708	103	2	did	do	AUX
concept-1708	103	3	,	,	PUNCT
concept-1708	103	4	however	however	ADV
concept-1708	103	5	,	,	PUNCT
concept-1708	103	6	describe	describe	VERB
concept-1708	103	7	the	the	DET
concept-1708	103	8	steps	step	NOUN
concept-1708	103	9	in	in	ADP
concept-1708	103	10	similar	similar	ADJ
concept-1708	103	11	ways	way	NOUN
concept-1708	103	12	and	and	CCONJ
concept-1708	103	13	,	,	PUNCT
concept-1708	103	14	for	for	ADP
concept-1708	103	15	the	the	DET
concept-1708	103	16	most	most	ADJ
concept-1708	103	17	part	part	NOUN
concept-1708	103	18	,	,	PUNCT
concept-1708	103	19	agreed	agree	VERB
concept-1708	103	20	on	on	ADP
concept-1708	103	21	the	the	DET
concept-1708	103	22	relative	relative	ADJ
concept-1708	103	23	importance	importance	NOUN
concept-1708	103	24	of	of	ADP
concept-1708	103	25	each	each	DET
concept-1708	103	26	stage	stage	NOUN
concept-1708	103	27	(	(	PUNCT
concept-1708	103	28	5	5	NUM
concept-1708	103	29	)	)	PUNCT
concept-1708	103	30	.	.	PUNCT
concept-1708	104	1	visualization	visualization	NOUN
concept-1708	104	2	of	of	ADP
concept-1708	104	3	expert	expert	ADJ
concept-1708	104	4	views	view	NOUN
concept-1708	104	5	about	about	ADP
concept-1708	104	6	the	the	DET
concept-1708	104	7	important	important	ADJ
concept-1708	104	8	stages	stage	NOUN
concept-1708	104	9	of	of	ADP
concept-1708	104	10	metastasis	metastasis	NOUN
concept-1708	104	11	(	(	PUNCT
concept-1708	104	12	9	9	NUM
concept-1708	104	13	)	)	PUNCT
concept-1708	104	14	since	since	SCONJ
concept-1708	104	15	there	there	PRON
concept-1708	104	16	was	be	VERB
concept-1708	104	17	a	a	DET
concept-1708	104	18	significant	significant	ADJ
concept-1708	104	19	disparity	disparity	NOUN
concept-1708	104	20	in	in	ADP
concept-1708	104	21	how	how	SCONJ
concept-1708	104	22	each	each	DET
concept-1708	104	23	expert	expert	NOUN
concept-1708	104	24	considered	consider	VERB
concept-1708	104	25	the	the	DET
concept-1708	104	26	metastatic	metastatic	ADJ
concept-1708	104	27	process	process	NOUN
concept-1708	104	28	,	,	PUNCT
concept-1708	104	29	the	the	DET
concept-1708	104	30	team	team	NOUN
concept-1708	104	31	introduced	introduce	VERB
concept-1708	104	32	a	a	DET
concept-1708	104	33	metric	metric	NOUN
concept-1708	104	34	to	to	PART
concept-1708	104	35	compare	compare	VERB
concept-1708	104	36	two	two	NUM
concept-1708	104	37	series	series	NOUN
concept-1708	104	38	of	of	ADP
concept-1708	104	39	elements	element	NOUN
concept-1708	104	40	(	(	PUNCT
concept-1708	104	41	two	two	NUM
concept-1708	104	42	experts	expert	NOUN
concept-1708	104	43	’	’	PART
concept-1708	104	44	descriptions	description	NOUN
concept-1708	104	45	)	)	PUNCT
concept-1708	104	46	to	to	PART
concept-1708	104	47	determine	determine	VERB
concept-1708	104	48	the	the	DET
concept-1708	104	49	probability	probability	NOUN
concept-1708	104	50	of	of	ADP
concept-1708	104	51	any	any	DET
concept-1708	104	52	random	random	ADJ
concept-1708	104	53	pair	pair	NOUN
concept-1708	104	54	of	of	ADP
concept-1708	104	55	experts	expert	NOUN
concept-1708	104	56	agreeing	agree	VERB
concept-1708	104	57	or	or	CCONJ
concept-1708	104	58	disagreeing	disagree	VERB
concept-1708	104	59	on	on	ADP
concept-1708	104	60	at	at	ADP
concept-1708	104	61	least	least	ADJ
concept-1708	104	62	k	k	NOUN
concept-1708	104	63	statements	statement	NOUN
concept-1708	104	64	(	(	PUNCT
concept-1708	104	65	5	5	NUM
concept-1708	104	66	)	)	PUNCT
concept-1708	104	67	.	.	PUNCT
concept-1708	105	1	they	they	PRON
concept-1708	105	2	noted	note	VERB
concept-1708	105	3	that	that	SCONJ
concept-1708	105	4	the	the	DET
concept-1708	105	5	probability	probability	NOUN
concept-1708	105	6	of	of	ADP
concept-1708	105	7	agreement	agreement	NOUN
concept-1708	105	8	quickly	quickly	ADV
concept-1708	105	9	dropped	drop	VERB
concept-1708	105	10	with	with	ADP
concept-1708	105	11	k	k	NOUN
concept-1708	105	12	increasing	increase	VERB
concept-1708	105	13	while	while	SCONJ
concept-1708	105	14	the	the	DET
concept-1708	105	15	probability	probability	NOUN
concept-1708	105	16	of	of	ADP
concept-1708	105	17	disagreement	disagreement	NOUN
concept-1708	105	18	grew	grow	VERB
concept-1708	105	19	more	more	ADV
concept-1708	105	20	gradually	gradually	ADV
concept-1708	105	21	,	,	PUNCT
concept-1708	105	22	which	which	PRON
concept-1708	105	23	is	be	AUX
concept-1708	105	24	shown	show	VERB
concept-1708	105	25	in	in	ADP
concept-1708	105	26	the	the	DET
concept-1708	105	27	graph	graph	NOUN
concept-1708	105	28	below	below	ADV
concept-1708	105	29	.	.	PUNCT
concept-1708	105	30	  	  	SPACE
concept-1708	105	31	quantifying	quantify	VERB
concept-1708	105	32	the	the	DET
concept-1708	105	33	agreement	agreement	NOUN
concept-1708	105	34	between	between	ADP
concept-1708	105	35	expert	expert	NOUN
concept-1708	105	36	scenarios	scenario	NOUN
concept-1708	105	37	of	of	ADP
concept-1708	105	38	metastasis	metastasis	NOUN
concept-1708	105	39	(	(	PUNCT
concept-1708	105	40	9	9	NUM
concept-1708	105	41	)	)	PUNCT
concept-1708	105	42	in	in	ADP
concept-1708	105	43	the	the	DET
concept-1708	105	44	conclusion	conclusion	NOUN
concept-1708	105	45	of	of	ADP
concept-1708	105	46	their	their	PRON
concept-1708	105	47	study	study	NOUN
concept-1708	105	48	,	,	PUNCT
concept-1708	105	49	divoli	divoli	ADP
concept-1708	105	50	et	et	PROPN
concept-1708	105	51	al	al	PROPN
concept-1708	105	52	.	.	PROPN
concept-1708	105	53	noted	note	VERB
concept-1708	105	54	that	that	SCONJ
concept-1708	105	55	the	the	DET
concept-1708	105	56	results	result	NOUN
concept-1708	105	57	they	they	PRON
concept-1708	105	58	found	find	VERB
concept-1708	105	59	were	be	AUX
concept-1708	105	60	much	much	ADV
concept-1708	105	61	more	more	ADV
concept-1708	105	62	diverse	diverse	ADJ
concept-1708	105	63	and	and	CCONJ
concept-1708	105	64	disconnected	disconnected	ADJ
concept-1708	105	65	than	than	SCONJ
concept-1708	105	66	they	they	PRON
concept-1708	105	67	were	be	AUX
concept-1708	105	68	expecting	expect	VERB
concept-1708	105	69	(	(	PUNCT
concept-1708	105	70	5	5	NUM
concept-1708	105	71	)	)	PUNCT
concept-1708	105	72	.	.	PUNCT
concept-1708	106	1	the	the	DET
concept-1708	106	2	team	team	NOUN
concept-1708	106	3	anticipated	anticipate	VERB
concept-1708	106	4	some	some	DET
concept-1708	106	5	disparity	disparity	NOUN
concept-1708	106	6	in	in	ADP
concept-1708	106	7	the	the	DET
concept-1708	106	8	experts	expert	NOUN
concept-1708	106	9	’	’	PART
concept-1708	106	10	opinions	opinion	NOUN
concept-1708	106	11	of	of	ADP
concept-1708	106	12	the	the	DET
concept-1708	106	13	smaller	small	ADJ
concept-1708	106	14	details	detail	NOUN
concept-1708	106	15	but	but	CCONJ
concept-1708	106	16	thought	think	VERB
concept-1708	106	17	they	they	PRON
concept-1708	106	18	would	would	AUX
concept-1708	106	19	agree	agree	VERB
concept-1708	106	20	on	on	ADP
concept-1708	106	21	the	the	DET
concept-1708	106	22	larger	large	ADJ
concept-1708	106	23	,	,	PUNCT
concept-1708	106	24	more	more	ADV
concept-1708	106	25	important	important	ADJ
concept-1708	106	26	aspects	aspect	NOUN
concept-1708	106	27	of	of	ADP
concept-1708	106	28	the	the	DET
concept-1708	106	29	process	process	NOUN
concept-1708	106	30	.	.	PUNCT
concept-1708	107	1	however	however	ADV
concept-1708	107	2	,	,	PUNCT
concept-1708	107	3	each	each	DET
concept-1708	107	4	expert	expert	NOUN
concept-1708	107	5	’s	’s	PART
concept-1708	107	6	interpretation	interpretation	NOUN
concept-1708	107	7	of	of	ADP
concept-1708	107	8	metastasis	metastasis	NOUN
concept-1708	107	9	was	be	AUX
concept-1708	107	10	distinctly	distinctly	ADV
concept-1708	107	11	different	different	ADJ
concept-1708	107	12	from	from	ADP
concept-1708	107	13	the	the	DET
concept-1708	107	14	rest	rest	NOUN
concept-1708	107	15	.	.	PUNCT
concept-1708	108	1	the	the	DET
concept-1708	108	2	amount	amount	NOUN
concept-1708	108	3	of	of	ADP
concept-1708	108	4	disproportion	disproportion	NOUN
concept-1708	108	5	in	in	ADP
concept-1708	108	6	the	the	DET
concept-1708	108	7	results	result	NOUN
concept-1708	108	8	reinforces	reinforce	VERB
concept-1708	108	9	the	the	DET
concept-1708	108	10	notion	notion	NOUN
concept-1708	108	11	that	that	SCONJ
concept-1708	108	12	metastasis	metastasis	NOUN
concept-1708	108	13	is	be	AUX
concept-1708	108	14	an	an	DET
concept-1708	108	15	extremely	extremely	ADV
concept-1708	108	16	complex	complex	ADJ
concept-1708	108	17	process	process	NOUN
concept-1708	108	18	with	with	ADP
concept-1708	108	19	many	many	ADJ
concept-1708	108	20	different	different	ADJ
concept-1708	108	21	factors	factor	NOUN
concept-1708	108	22	and	and	CCONJ
concept-1708	108	23	possible	possible	ADJ
concept-1708	108	24	paths	path	NOUN
concept-1708	108	25	.	.	PUNCT
concept-1708	109	1	the	the	DET
concept-1708	109	2	markov	markov	NOUN
concept-1708	109	3	model	model	NOUN
concept-1708	109	4	that	that	SCONJ
concept-1708	109	5	divoli	divoli	ADP
concept-1708	109	6	et	et	PROPN
concept-1708	109	7	al	al	PROPN
concept-1708	109	8	.	.	PROPN
concept-1708	109	9	presented	present	VERB
concept-1708	109	10	is	be	AUX
concept-1708	109	11	a	a	DET
concept-1708	109	12	first	first	ADJ
concept-1708	109	13	step	step	NOUN
concept-1708	109	14	and	and	CCONJ
concept-1708	109	15	incentive	incentive	NOUN
concept-1708	109	16	to	to	PART
concept-1708	109	17	continue	continue	VERB
concept-1708	109	18	further	further	ADJ
concept-1708	109	19	research	research	NOUN
concept-1708	109	20	and	and	CCONJ
concept-1708	109	21	development	development	NOUN
concept-1708	109	22	of	of	ADP
concept-1708	109	23	a	a	DET
concept-1708	109	24	standardized	standardized	ADJ
concept-1708	109	25	consensus	consensus	NOUN
concept-1708	109	26	to	to	PART
concept-1708	109	27	gauge	gauge	VERB
concept-1708	109	28	individual	individual	ADJ
concept-1708	109	29	cancer	cancer	NOUN
concept-1708	109	30	progression	progression	NOUN
concept-1708	109	31	so	so	SCONJ
concept-1708	109	32	that	that	SCONJ
concept-1708	109	33	clinicians	clinician	NOUN
concept-1708	109	34	will	will	AUX
concept-1708	109	35	be	be	AUX
concept-1708	109	36	able	able	ADJ
concept-1708	109	37	to	to	PART
concept-1708	109	38	better	well	ADV
concept-1708	109	39	predict	predict	VERB
concept-1708	109	40	how	how	SCONJ
concept-1708	109	41	metastasis	metastasis	NOUN
concept-1708	109	42	will	will	AUX
concept-1708	109	43	progress	progress	VERB
concept-1708	109	44	in	in	ADP
concept-1708	109	45	every	every	DET
concept-1708	109	46	case	case	NOUN
concept-1708	109	47	.	.	PUNCT
concept-1708	109	48	  	  	SPACE
concept-1708	110	1	b.	b.	PROPN
concept-1708	110	2	partial	partial	ADJ
concept-1708	110	3	differential	differential	NOUN
concept-1708	110	4	equations	equation	NOUN
concept-1708	110	5	ramis	ramis	PROPN
concept-1708	110	6	-	-	PUNCT
concept-1708	110	7	conde	conde	PROPN
concept-1708	110	8	et	et	PROPN
concept-1708	110	9	al	al	PROPN
concept-1708	110	10	.	.	PROPN
concept-1708	111	1	(	(	PUNCT
concept-1708	111	2	9	9	X
concept-1708	111	3	)	)	PUNCT
concept-1708	111	4	focused	focus	VERB
concept-1708	111	5	their	their	PRON
concept-1708	111	6	study	study	NOUN
concept-1708	111	7	of	of	ADP
concept-1708	111	8	metastasis	metastasis	NOUN
concept-1708	111	9	development	development	NOUN
concept-1708	111	10	not	not	PART
concept-1708	111	11	on	on	ADP
concept-1708	111	12	the	the	DET
concept-1708	111	13	stages	stage	NOUN
concept-1708	111	14	or	or	CCONJ
concept-1708	111	15	chain	chain	NOUN
concept-1708	111	16	of	of	ADP
concept-1708	111	17	cancer	cancer	NOUN
concept-1708	111	18	cell	cell	NOUN
concept-1708	111	19	movement	movement	NOUN
concept-1708	111	20	,	,	PUNCT
concept-1708	111	21	but	but	CCONJ
concept-1708	111	22	on	on	ADP
concept-1708	111	23	how	how	SCONJ
concept-1708	111	24	the	the	DET
concept-1708	111	25	ctcs	ctcs	NOUN
concept-1708	111	26	are	be	AUX
concept-1708	111	27	able	able	ADJ
concept-1708	111	28	to	to	PART
concept-1708	111	29	leave	leave	VERB
concept-1708	111	30	the	the	DET
concept-1708	111	31	original	original	ADJ
concept-1708	111	32	tumor	tumor	NOUN
concept-1708	111	33	to	to	PART
concept-1708	111	34	migrate	migrate	VERB
concept-1708	111	35	to	to	ADP
concept-1708	111	36	other	other	ADJ
concept-1708	111	37	organs	organ	NOUN
concept-1708	111	38	and	and	CCONJ
concept-1708	111	39	tissues	tissue	NOUN
concept-1708	111	40	.	.	PUNCT
concept-1708	112	1	they	they	PRON
concept-1708	112	2	acknowledged	acknowledge	VERB
concept-1708	112	3	that	that	SCONJ
concept-1708	112	4	it	it	PRON
concept-1708	112	5	is	be	AUX
concept-1708	112	6	first	first	ADV
concept-1708	112	7	necessary	necessary	ADJ
concept-1708	112	8	for	for	SCONJ
concept-1708	112	9	the	the	DET
concept-1708	112	10	cancerous	cancerous	ADJ
concept-1708	112	11	cells	cell	NOUN
concept-1708	112	12	to	to	PART
concept-1708	112	13	penetrate	penetrate	VERB
concept-1708	112	14	the	the	DET
concept-1708	112	15	extracellular	extracellular	ADJ
concept-1708	112	16	matrix	matrix	NOUN
concept-1708	112	17	(	(	PUNCT
concept-1708	112	18	ecm	ecm	NOUN
concept-1708	112	19	)	)	PUNCT
concept-1708	112	20	of	of	ADP
concept-1708	112	21	the	the	DET
concept-1708	112	22	original	original	ADJ
concept-1708	112	23	site	site	NOUN
concept-1708	112	24	in	in	ADP
concept-1708	112	25	order	order	NOUN
concept-1708	112	26	to	to	PART
concept-1708	112	27	invade	invade	VERB
concept-1708	112	28	surrounding	surround	VERB
concept-1708	112	29	tissue	tissue	NOUN
concept-1708	112	30	or	or	CCONJ
concept-1708	112	31	enter	enter	VERB
concept-1708	112	32	the	the	DET
concept-1708	112	33	blood	blood	NOUN
concept-1708	112	34	stream	stream	NOUN
concept-1708	112	35	or	or	CCONJ
concept-1708	112	36	lymphatic	lymphatic	ADJ
concept-1708	112	37	system	system	NOUN
concept-1708	112	38	to	to	PART
concept-1708	112	39	move	move	VERB
concept-1708	112	40	throughout	throughout	ADP
concept-1708	112	41	the	the	DET
concept-1708	112	42	body	body	NOUN
concept-1708	112	43	.	.	PUNCT
concept-1708	113	1	they	they	PRON
concept-1708	113	2	noted	note	VERB
concept-1708	113	3	that	that	SCONJ
concept-1708	113	4	the	the	DET
concept-1708	113	5	cancer	cancer	NOUN
concept-1708	113	6	cells	cell	NOUN
concept-1708	113	7	must	must	AUX
concept-1708	113	8	have	have	VERB
concept-1708	113	9	the	the	DET
concept-1708	113	10	capability	capability	NOUN
concept-1708	113	11	to	to	PART
concept-1708	113	12	produce	produce	VERB
concept-1708	113	13	reactions	reaction	NOUN
concept-1708	113	14	that	that	PRON
concept-1708	113	15	would	would	AUX
concept-1708	113	16	allow	allow	VERB
concept-1708	113	17	them	they	PRON
concept-1708	113	18	to	to	PART
concept-1708	113	19	travel	travel	VERB
concept-1708	113	20	through	through	ADP
concept-1708	113	21	the	the	DET
concept-1708	113	22	ecm	ecm	NOUN
concept-1708	113	23	,	,	PUNCT
concept-1708	113	24	which	which	PRON
concept-1708	113	25	would	would	AUX
concept-1708	113	26	require	require	VERB
concept-1708	113	27	degradation	degradation	NOUN
concept-1708	113	28	of	of	ADP
concept-1708	113	29	the	the	DET
concept-1708	113	30	ecm	ecm	NOUN
concept-1708	113	31	.	.	PUNCT
concept-1708	114	1	therefore	therefore	ADV
concept-1708	114	2	,	,	PUNCT
concept-1708	114	3	they	they	PRON
concept-1708	114	4	developed	develop	VERB
concept-1708	114	5	a	a	DET
concept-1708	114	6	hybrid	hybrid	ADJ
concept-1708	114	7	model	model	NOUN
concept-1708	114	8	using	use	VERB
concept-1708	114	9	partial	partial	ADJ
concept-1708	114	10	differential	differential	ADJ
concept-1708	114	11	equations	equation	NOUN
concept-1708	114	12	that	that	PRON
concept-1708	114	13	incorporated	incorporate	VERB
concept-1708	114	14	the	the	DET
concept-1708	114	15	interactions	interaction	NOUN
concept-1708	114	16	of	of	ADP
concept-1708	114	17	individual	individual	ADJ
concept-1708	114	18	cells	cell	NOUN
concept-1708	114	19	with	with	ADP
concept-1708	114	20	the	the	DET
concept-1708	114	21	ecm	ecm	NOUN
concept-1708	114	22	as	as	ADV
concept-1708	114	23	well	well	ADV
concept-1708	114	24	as	as	ADP
concept-1708	114	25	the	the	DET
concept-1708	114	26	interactions	interaction	NOUN
concept-1708	114	27	of	of	ADP
concept-1708	114	28	cells	cell	NOUN
concept-1708	114	29	with	with	ADP
concept-1708	114	30	each	each	DET
concept-1708	114	31	other	other	ADJ
concept-1708	114	32	.	.	PUNCT
concept-1708	115	1	the	the	DET
concept-1708	115	2	first	first	ADJ
concept-1708	115	3	part	part	NOUN
concept-1708	115	4	of	of	ADP
concept-1708	115	5	their	their	PRON
concept-1708	115	6	model	model	NOUN
concept-1708	115	7	assumes	assume	VERB
concept-1708	115	8	that	that	SCONJ
concept-1708	115	9	the	the	DET
concept-1708	115	10	process	process	NOUN
concept-1708	115	11	of	of	ADP
concept-1708	115	12	migration	migration	NOUN
concept-1708	115	13	of	of	ADP
concept-1708	115	14	a	a	DET
concept-1708	115	15	ctc	ctc	NOUN
concept-1708	115	16	through	through	ADP
concept-1708	115	17	the	the	DET
concept-1708	115	18	ecm	ecm	PROPN
concept-1708	115	19	is	be	AUX
concept-1708	115	20	triggered	trigger	VERB
concept-1708	115	21	by	by	ADP
concept-1708	115	22	contact	contact	NOUN
concept-1708	115	23	between	between	ADP
concept-1708	115	24	the	the	DET
concept-1708	115	25	ecm	ecm	NOUN
concept-1708	115	26	and	and	CCONJ
concept-1708	115	27	the	the	DET
concept-1708	115	28	cell	cell	NOUN
concept-1708	115	29	(	(	PUNCT
concept-1708	115	30	9	9	NUM
concept-1708	115	31	)	)	PUNCT
concept-1708	115	32	.	.	PUNCT
concept-1708	116	1	when	when	SCONJ
concept-1708	116	2	a	a	DET
concept-1708	116	3	cancer	cancer	NOUN
concept-1708	116	4	cell	cell	NOUN
concept-1708	116	5	touches	touch	VERB
concept-1708	116	6	the	the	DET
concept-1708	116	7	ecm	ecm	NOUN
concept-1708	116	8	,	,	PUNCT
concept-1708	116	9	it	it	PRON
concept-1708	116	10	releases	release	VERB
concept-1708	116	11	matrix	matrix	NOUN
concept-1708	116	12	metalloproteinases	metalloproteinase	NOUN
concept-1708	116	13	(	(	PUNCT
concept-1708	116	14	mmps	mmp	NOUN
concept-1708	116	15	)	)	PUNCT
concept-1708	116	16	to	to	PART
concept-1708	116	17	degrade	degrade	VERB
concept-1708	116	18	it	it	PRON
concept-1708	116	19	.	.	PUNCT
concept-1708	117	1	they	they	PRON
concept-1708	117	2	defined	define	VERB
concept-1708	117	3	the	the	DET
concept-1708	117	4	following	follow	VERB
concept-1708	117	5	equations	equation	NOUN
concept-1708	117	6	:	:	PUNCT
concept-1708	117	7	𝜕	𝜕	PROPN
concept-1708	117	8	𝜕𝑡	𝜕𝑡	PROPN
concept-1708	117	9	𝐸	𝐸	PROPN
concept-1708	117	10	𝑥	𝑥	PROPN
concept-1708	117	11	,	,	PUNCT
concept-1708	117	12	𝑡	𝑡	PROPN
concept-1708	117	13	=	=	PUNCT
concept-1708	117	14	𝜆𝑁	𝜆𝑁	PROPN
concept-1708	118	1	𝑥	𝑥	NOUN
concept-1708	118	2	,	,	PUNCT
concept-1708	118	3	𝑡	𝑡	PROPN
concept-1708	118	4	𝑀	𝑀	PROPN
concept-1708	118	5	𝑥	𝑥	PROPN
concept-1708	118	6	,	,	PUNCT
concept-1708	118	7	𝑡	𝑡	X
concept-1708	118	8	+	+	X
concept-1708	118	9	𝜒!δ𝐸	𝜒!δ𝐸	PROPN
concept-1708	118	10	𝑥	𝑥	PROPN
concept-1708	118	11	,	,	PUNCT
concept-1708	118	12	𝑡	𝑡	X
concept-1708	118	13	−	−	NOUN
concept-1708	118	14	𝜇!𝐸	𝜇!𝐸	ADP
concept-1708	118	15	𝑥	𝑥	PROPN
concept-1708	118	16	,	,	PUNCT
concept-1708	118	17	𝑡	𝑡	X
concept-1708	118	18	,	,	PUNCT
concept-1708	118	19	1	1	NUM
concept-1708	118	20	𝜕	𝜕	PROPN
concept-1708	118	21	𝜕𝑡	𝜕𝑡	PROPN
concept-1708	118	22	𝑀	𝑀	PROPN
concept-1708	118	23	𝑥	𝑥	PROPN
concept-1708	118	24	,	,	PUNCT
concept-1708	118	25	𝑡	𝑡	PROPN
concept-1708	118	26	=	=	NOUN
concept-1708	119	1	−𝛽𝐸	−𝛽𝐸	NUM
concept-1708	119	2	𝑥	𝑥	PROPN
concept-1708	119	3	,	,	PUNCT
concept-1708	119	4	𝑡	𝑡	PROPN
concept-1708	119	5	𝑀	𝑀	PROPN
concept-1708	119	6	𝑥	𝑥	PROPN
concept-1708	119	7	,	,	PUNCT
concept-1708	119	8	𝑡	𝑡	PROPN
concept-1708	119	9	,	,	PUNCT
concept-1708	119	10	𝜕	𝜕	PROPN
concept-1708	119	11	𝜕𝑡	𝜕𝑡	PROPN
concept-1708	119	12	𝐴	𝐴	PROPN
concept-1708	119	13	𝑥	𝑥	PROPN
concept-1708	119	14	,	,	PUNCT
concept-1708	119	15	𝑡	𝑡	PROPN
concept-1708	119	16	=	=	PROPN
concept-1708	119	17	𝛾𝐸	𝛾𝐸	PROPN
concept-1708	119	18	𝑥	𝑥	PROPN
concept-1708	119	19	,	,	PUNCT
concept-1708	119	20	𝑡	𝑡	PROPN
concept-1708	119	21	𝑀	𝑀	PROPN
concept-1708	119	22	𝑥	𝑥	PROPN
concept-1708	119	23	,	,	PUNCT
concept-1708	119	24	𝑡	𝑡	PROPN
concept-1708	119	25	+	+	ADP
concept-1708	119	26	𝜒!δ𝐴	𝜒!δ𝐴	PROPN
concept-1708	119	27	𝑥	𝑥	NOUN
concept-1708	119	28	,	,	PUNCT
concept-1708	119	29	𝑡	𝑡	PROPN
concept-1708	119	30	−	−	PROPN
concept-1708	119	31	𝜇!𝐴	𝜇!𝐴	PROPN
concept-1708	119	32	𝑥	𝑥	PROPN
concept-1708	119	33	,	,	PUNCT
concept-1708	119	34	𝑡	𝑡	PROPN
concept-1708	119	35	,	,	PUNCT
concept-1708	119	36	where	where	SCONJ
concept-1708	119	37	m	m	PROPN
concept-1708	119	38	is	be	AUX
concept-1708	119	39	the	the	DET
concept-1708	119	40	density	density	NOUN
concept-1708	119	41	of	of	ADP
concept-1708	119	42	the	the	DET
concept-1708	119	43	ecm	ecm	NOUN
concept-1708	119	44	,	,	PUNCT
concept-1708	119	45	e	e	X
concept-1708	119	46	is	be	AUX
concept-1708	119	47	the	the	DET
concept-1708	119	48	concentration	concentration	NOUN
concept-1708	119	49	of	of	ADP
concept-1708	119	50	the	the	DET
concept-1708	119	51	mmps	mmp	NOUN
concept-1708	119	52	,	,	PUNCT
concept-1708	119	53	and	and	CCONJ
concept-1708	119	54	a	a	PRON
concept-1708	119	55	is	be	AUX
concept-1708	119	56	the	the	DET
concept-1708	119	57	resulting	result	VERB
concept-1708	119	58	density	density	NOUN
concept-1708	119	59	of	of	ADP
concept-1708	119	60	the	the	DET
concept-1708	119	61	degraded	degraded	ADJ
concept-1708	119	62	ecm	ecm	NOUN
concept-1708	119	63	,	,	PUNCT
concept-1708	119	64	which	which	PRON
concept-1708	119	65	stimulates	stimulate	VERB
concept-1708	119	66	sells	sell	VERB
concept-1708	119	67	to	to	PART
concept-1708	119	68	migrate	migrate	VERB
concept-1708	119	69	through	through	ADP
concept-1708	119	70	the	the	DET
concept-1708	119	71	ecm	ecm	NOUN
concept-1708	119	72	.	.	PUNCT
concept-1708	120	1	the	the	DET
concept-1708	120	2	tumor	tumor	NOUN
concept-1708	120	3	cell	cell	NOUN
concept-1708	120	4	size	size	NOUN
concept-1708	120	5	n	n	CCONJ
concept-1708	120	6	at	at	ADP
concept-1708	120	7	a	a	DET
concept-1708	120	8	time	time	NOUN
concept-1708	120	9	t	t	NOUN
concept-1708	120	10	in	in	ADP
concept-1708	120	11	a	a	DET
concept-1708	120	12	neighborhood	neighborhood	NOUN
concept-1708	120	13	of	of	ADP
concept-1708	120	14	x	x	PUNCT
concept-1708	120	15	is	be	AUX
concept-1708	120	16	defined	define	VERB
concept-1708	120	17	by	by	ADP
concept-1708	120	18	𝑁	𝑁	PROPN
concept-1708	120	19	𝑥	𝑥	PROPN
concept-1708	120	20	,	,	PUNCT
concept-1708	120	21	𝑡	𝑡	PROPN
concept-1708	120	22	=	=	SYM
concept-1708	120	23	𝐼	𝐼	PROPN
concept-1708	120	24	!	!	PUNCT
concept-1708	120	25	!	!	PUNCT
concept-1708	120	26	!	!	PUNCT
concept-1708	121	1	(	(	PUNCT
concept-1708	121	2	𝑥	𝑥	X
concept-1708	121	3	!	!	PUNCT
concept-1708	121	4	!	!	PUNCT
concept-1708	121	5	!	!	PUNCT
concept-1708	121	6	!	!	PUNCT
concept-1708	121	7	!	!	PUNCT
concept-1708	121	8	!	!	PUNCT
concept-1708	121	9	!	!	PUNCT
concept-1708	121	10	)	)	PUNCT
concept-1708	122	1	where	where	SCONJ
concept-1708	122	2	ibε(x)(xi	ibε(x)(xi	X
concept-1708	122	3	)	)	PUNCT
concept-1708	122	4	is	be	AUX
concept-1708	122	5	a	a	DET
concept-1708	122	6	heavyside	heavyside	NOUN
concept-1708	122	7	function	function	NOUN
concept-1708	122	8	  	  	SPACE
concept-1708	122	9	and	and	CCONJ
concept-1708	122	10	bε(x	bε(x	NOUN
concept-1708	122	11	)	)	PUNCT
concept-1708	122	12	is	be	AUX
concept-1708	122	13	the	the	DET
concept-1708	122	14	ball	ball	NOUN
concept-1708	122	15	of	of	ADP
concept-1708	122	16	radius	radius	PROPN
concept-1708	122	17	ε	ε	PROPN
concept-1708	122	18	,	,	PUNCT
concept-1708	122	19	centered	center	VERB
concept-1708	122	20	at	at	ADP
concept-1708	122	21	x.	x.	PROPN
concept-1708	122	22	xi	xi	PROPN
concept-1708	122	23	is	be	AUX
concept-1708	122	24	the	the	DET
concept-1708	122	25	position	position	NOUN
concept-1708	122	26	of	of	ADP
concept-1708	122	27	the	the	DET
concept-1708	122	28	ith	ith	PROPN
concept-1708	122	29	cell	cell	NOUN
concept-1708	122	30	.	.	PUNCT
concept-1708	123	1	1	1	NUM
concept-1708	123	2	refers	refer	VERB
concept-1708	123	3	to	to	ADP
concept-1708	123	4	the	the	DET
concept-1708	123	5	immediate	immediate	ADJ
concept-1708	123	6	production	production	NOUN
concept-1708	123	7	of	of	ADP
concept-1708	123	8	enzymes	enzyme	NOUN
concept-1708	123	9	by	by	ADP
concept-1708	123	10	the	the	DET
concept-1708	123	11	cells	cell	NOUN
concept-1708	123	12	within	within	ADP
concept-1708	123	13	that	that	DET
concept-1708	123	14	radius	radius	NOUN
concept-1708	123	15	,	,	PUNCT
concept-1708	123	16	meaning	mean	VERB
concept-1708	123	17	that	that	SCONJ
concept-1708	123	18	production	production	NOUN
concept-1708	123	19	is	be	AUX
concept-1708	123	20	non	non	ADJ
concept-1708	123	21	-	-	ADJ
concept-1708	123	22	existent	existent	ADJ
concept-1708	123	23	(	(	PUNCT
concept-1708	123	24	0	0	NUM
concept-1708	123	25	)	)	PUNCT
concept-1708	123	26	if	if	SCONJ
concept-1708	123	27	it	it	PRON
concept-1708	123	28	is	be	AUX
concept-1708	123	29	outside	outside	ADP
concept-1708	123	30	of	of	ADP
concept-1708	123	31	the	the	DET
concept-1708	123	32	radius	radius	NOUN
concept-1708	123	33	.	.	PUNCT
concept-1708	124	1	they	they	PRON
concept-1708	124	2	incorporated	incorporate	VERB
concept-1708	124	3	the	the	DET
concept-1708	124	4	interactions	interaction	NOUN
concept-1708	124	5	between	between	ADP
concept-1708	124	6	cells	cell	NOUN
concept-1708	124	7	in	in	ADP
concept-1708	124	8	this	this	DET
concept-1708	124	9	model	model	NOUN
concept-1708	124	10	by	by	ADP
concept-1708	124	11	assuming	assume	VERB
concept-1708	124	12	they	they	PRON
concept-1708	124	13	would	would	AUX
concept-1708	124	14	interact	interact	VERB
concept-1708	124	15	via	via	ADP
concept-1708	124	16	the	the	DET
concept-1708	124	17	potential	potential	ADJ
concept-1708	124	18	function	function	NOUN
concept-1708	124	19	below	below	ADV
concept-1708	124	20	if	if	SCONJ
concept-1708	124	21	their	their	PRON
concept-1708	124	22	distance	distance	NOUN
concept-1708	124	23	apart	apart	ADV
concept-1708	124	24	is	be	AUX
concept-1708	124	25	less	less	ADJ
concept-1708	124	26	than	than	ADP
concept-1708	124	27	ε	ε	PROPN
concept-1708	124	28	,	,	PUNCT
concept-1708	124	29	which	which	PRON
concept-1708	124	30	they	they	PRON
concept-1708	124	31	standardized	standardize	VERB
concept-1708	124	32	as	as	ADP
concept-1708	124	33	twice	twice	DET
concept-1708	124	34	the	the	DET
concept-1708	124	35	size	size	NOUN
concept-1708	124	36	of	of	ADP
concept-1708	124	37	the	the	DET
concept-1708	124	38	average	average	ADJ
concept-1708	124	39	cancer	cancer	NOUN
concept-1708	124	40	cell	cell	NOUN
concept-1708	124	41	.	.	PUNCT
concept-1708	125	1	the	the	DET
concept-1708	125	2	potential	potential	ADJ
concept-1708	125	3	energy	energy	NOUN
concept-1708	125	4	v	v	NOUN
concept-1708	125	5	between	between	ADP
concept-1708	125	6	two	two	NUM
concept-1708	125	7	cells	cell	NOUN
concept-1708	125	8	at	at	ADP
concept-1708	125	9	a	a	DET
concept-1708	125	10	time	time	NOUN
concept-1708	125	11	t	t	NOUN
concept-1708	125	12	is	be	AUX
concept-1708	125	13	given	give	VERB
concept-1708	125	14	by	by	ADP
concept-1708	125	15	where	where	SCONJ
concept-1708	125	16	d	d	NOUN
concept-1708	125	17	is	be	AUX
concept-1708	125	18	the	the	DET
concept-1708	125	19	distance	distance	NOUN
concept-1708	125	20	,	,	PUNCT
concept-1708	125	21	h	h	NOUN
concept-1708	125	22	is	be	AUX
concept-1708	125	23	the	the	DET
concept-1708	125	24	capacity	capacity	NOUN
concept-1708	125	25	to	to	PART
concept-1708	125	26	bond	bond	VERB
concept-1708	125	27	,	,	PUNCT
concept-1708	125	28	and	and	CCONJ
concept-1708	125	29	e∞	e∞	PROPN
concept-1708	125	30	is	be	AUX
concept-1708	125	31	the	the	DET
concept-1708	125	32	maximum	maximum	ADJ
concept-1708	125	33	possible	possible	ADJ
concept-1708	125	34	energy	energy	NOUN
concept-1708	125	35	.	.	PUNCT
concept-1708	126	1	they	they	PRON
concept-1708	126	2	represented	represent	VERB
concept-1708	126	3	the	the	DET
concept-1708	126	4	bonds	bond	NOUN
concept-1708	126	5	connecting	connect	VERB
concept-1708	126	6	a	a	DET
concept-1708	126	7	set	set	NOUN
concept-1708	126	8	of	of	ADP
concept-1708	126	9	cells	cell	NOUN
concept-1708	126	10	greater	great	ADJ
concept-1708	126	11	than	than	ADP
concept-1708	126	12	two	two	NUM
concept-1708	126	13	as	as	ADP
concept-1708	126	14	where	where	SCONJ
concept-1708	126	15	bε(xi	bε(xi	ADJ
concept-1708	126	16	)	)	PUNCT
concept-1708	126	17	is	be	AUX
concept-1708	126	18	a	a	DET
concept-1708	126	19	neighborhood	neighborhood	NOUN
concept-1708	126	20	with	with	ADP
concept-1708	126	21	center	center	NOUN
concept-1708	126	22	xi	xi	NOUN
concept-1708	126	23	and	and	CCONJ
concept-1708	126	24	radius	radius	NOUN
concept-1708	126	25	of	of	ADP
concept-1708	126	26	the	the	DET
concept-1708	126	27	maximum	maximum	ADJ
concept-1708	126	28	intercellular	intercellular	ADJ
concept-1708	126	29	distance	distance	NOUN
concept-1708	126	30	of	of	ADP
concept-1708	126	31	ε	ε	PROPN
concept-1708	126	32	.	.	PUNCT
concept-1708	127	1	they	they	PRON
concept-1708	127	2	assumed	assume	VERB
concept-1708	127	3	that	that	SCONJ
concept-1708	127	4	cells	cell	NOUN
concept-1708	127	5	would	would	AUX
concept-1708	127	6	move	move	VERB
concept-1708	127	7	closer	close	ADV
concept-1708	127	8	to	to	PART
concept-1708	127	9	minimize	minimize	VERB
concept-1708	127	10	the	the	DET
concept-1708	127	11	potential	potential	ADJ
concept-1708	127	12	function	function	NOUN
concept-1708	127	13	between	between	ADP
concept-1708	127	14	them	they	PRON
concept-1708	127	15	at	at	ADP
concept-1708	127	16	a	a	DET
concept-1708	127	17	constant	constant	ADJ
concept-1708	127	18	speed	speed	NOUN
concept-1708	127	19	,	,	PUNCT
concept-1708	127	20	defining	define	VERB
concept-1708	127	21	the	the	DET
concept-1708	127	22	direction	direction	NOUN
concept-1708	127	23	of	of	ADP
concept-1708	127	24	the	the	DET
concept-1708	127	25	cells	cell	NOUN
concept-1708	127	26	movement	movement	NOUN
concept-1708	127	27	(	(	PUNCT
concept-1708	127	28	d	d	NOUN
concept-1708	127	29	)	)	PUNCT
concept-1708	127	30	as	as	ADP
concept-1708	127	31	where	where	SCONJ
concept-1708	127	32	r	r	NOUN
concept-1708	127	33	indicates	indicate	VERB
concept-1708	127	34	the	the	DET
concept-1708	127	35	cells	cell	NOUN
concept-1708	127	36	’	’	PART
concept-1708	127	37	sensitivity	sensitivity	NOUN
concept-1708	127	38	to	to	ADP
concept-1708	127	39	the	the	DET
concept-1708	127	40	chemoattractants	chemoattractant	NOUN
concept-1708	127	41	—	—	PUNCT
concept-1708	127	42	properties	property	NOUN
concept-1708	127	43	that	that	PRON
concept-1708	127	44	incite	incite	VERB
concept-1708	127	45	cells	cell	NOUN
concept-1708	127	46	to	to	PART
concept-1708	127	47	interact	interact	VERB
concept-1708	127	48	with	with	ADP
concept-1708	127	49	each	each	DET
concept-1708	127	50	other	other	ADJ
concept-1708	127	51	.	.	PUNCT
concept-1708	128	1	as	as	SCONJ
concept-1708	128	2	they	they	PRON
concept-1708	128	3	proceeded	proceed	VERB
concept-1708	128	4	in	in	ADP
concept-1708	128	5	their	their	PRON
concept-1708	128	6	study	study	NOUN
concept-1708	128	7	,	,	PUNCT
concept-1708	128	8	ramis	ramis	PROPN
concept-1708	128	9	-	-	PUNCT
concept-1708	128	10	conde	conde	PROPN
concept-1708	128	11	et	et	PROPN
concept-1708	128	12	al	al	PROPN
concept-1708	128	13	.	.	PROPN
concept-1708	128	14	realized	realize	VERB
concept-1708	128	15	that	that	SCONJ
concept-1708	128	16	they	they	PRON
concept-1708	128	17	could	could	AUX
concept-1708	128	18	drop	drop	VERB
concept-1708	128	19	off	off	ADP
concept-1708	128	20	their	their	PRON
concept-1708	128	21	original	original	ADJ
concept-1708	128	22	equation	equation	NOUN
concept-1708	128	23	for	for	ADP
concept-1708	128	24	∂/∂t	∂/∂t	NOUN
concept-1708	128	25	e(x	e(x	NUM
concept-1708	128	26	,	,	PUNCT
concept-1708	128	27	t	t	PROPN
concept-1708	128	28	)	)	PUNCT
concept-1708	128	29	once	once	SCONJ
concept-1708	128	30	they	they	PRON
concept-1708	128	31	found	find	VERB
concept-1708	128	32	evidence	evidence	NOUN
concept-1708	128	33	that	that	SCONJ
concept-1708	128	34	the	the	DET
concept-1708	128	35	matrix	matrix	NOUN
concept-1708	128	36	degradation	degradation	NOUN
concept-1708	128	37	was	be	AUX
concept-1708	128	38	confined	confine	VERB
concept-1708	128	39	to	to	ADP
concept-1708	128	40	the	the	DET
concept-1708	128	41	areas	area	NOUN
concept-1708	128	42	of	of	ADP
concept-1708	128	43	the	the	DET
concept-1708	128	44	ecm	ecm	NOUN
concept-1708	128	45	in	in	ADP
concept-1708	128	46	contact	contact	NOUN
concept-1708	128	47	with	with	ADP
concept-1708	128	48	cells	cell	NOUN
concept-1708	128	49	,	,	PUNCT
concept-1708	128	50	and	and	CCONJ
concept-1708	128	51	that	that	SCONJ
concept-1708	128	52	the	the	DET
concept-1708	128	53	degradation	degradation	NOUN
concept-1708	128	54	process	process	NOUN
concept-1708	128	55	could	could	AUX
concept-1708	128	56	be	be	AUX
concept-1708	128	57	quantified	quantify	VERB
concept-1708	128	58	without	without	ADP
concept-1708	128	59	requiring	require	VERB
concept-1708	128	60	the	the	DET
concept-1708	128	61	knowledge	knowledge	NOUN
concept-1708	128	62	of	of	ADP
concept-1708	128	63	the	the	DET
concept-1708	128	64	concentration	concentration	NOUN
concept-1708	128	65	of	of	ADP
concept-1708	128	66	the	the	DET
concept-1708	128	67	mmps	mmp	NOUN
concept-1708	128	68	.	.	PUNCT
concept-1708	129	1	they	they	PRON
concept-1708	129	2	considered	consider	VERB
concept-1708	129	3	the	the	DET
concept-1708	129	4	more	more	ADV
concept-1708	129	5	straightforward	straightforward	ADJ
concept-1708	129	6	system	system	NOUN
concept-1708	129	7	which	which	PRON
concept-1708	129	8	they	they	PRON
concept-1708	129	9	solved	solve	VERB
concept-1708	129	10	to	to	PART
concept-1708	129	11	determine	determine	VERB
concept-1708	129	12	that	that	SCONJ
concept-1708	129	13	the	the	DET
concept-1708	129	14	ecm	ecm	PROPN
concept-1708	129	15	is	be	AUX
concept-1708	129	16	defined	define	VERB
concept-1708	129	17	by	by	ADP
concept-1708	129	18	  	  	SPACE
concept-1708	129	19	and	and	CCONJ
concept-1708	129	20	the	the	DET
concept-1708	129	21	density	density	NOUN
concept-1708	129	22	of	of	ADP
concept-1708	129	23	the	the	DET
concept-1708	129	24	degraded	degraded	ADJ
concept-1708	129	25	ecm	ecm	NOUN
concept-1708	129	26	by	by	ADP
concept-1708	129	27	an	an	DET
concept-1708	129	28	individual	individual	ADJ
concept-1708	129	29	cell	cell	NOUN
concept-1708	129	30	is	be	AUX
concept-1708	129	31	given	give	VERB
concept-1708	129	32	by	by	ADP
concept-1708	129	33	,	,	PUNCT
concept-1708	129	34	taking	take	VERB
concept-1708	129	35	into	into	ADP
concept-1708	129	36	account	account	NOUN
concept-1708	129	37	the	the	DET
concept-1708	129	38	chemoattractants	chemoattractant	NOUN
concept-1708	129	39	it	it	PRON
concept-1708	129	40	is	be	AUX
concept-1708	129	41	simultaneously	simultaneously	ADV
concept-1708	129	42	releasing	release	VERB
concept-1708	129	43	.	.	PUNCT
concept-1708	130	1	while	while	SCONJ
concept-1708	130	2	they	they	PRON
concept-1708	130	3	began	begin	VERB
concept-1708	130	4	their	their	PRON
concept-1708	130	5	study	study	NOUN
concept-1708	130	6	hoping	hope	VERB
concept-1708	130	7	to	to	PART
concept-1708	130	8	demonstrate	demonstrate	VERB
concept-1708	130	9	how	how	SCONJ
concept-1708	130	10	one	one	NUM
concept-1708	130	11	cell	cell	NOUN
concept-1708	130	12	degrades	degrade	VERB
concept-1708	130	13	the	the	DET
concept-1708	130	14	ecm	ecm	NOUN
concept-1708	130	15	and	and	CCONJ
concept-1708	130	16	contributes	contribute	VERB
concept-1708	130	17	to	to	ADP
concept-1708	130	18	cancer	cancer	NOUN
concept-1708	130	19	spread	spread	NOUN
concept-1708	130	20	,	,	PUNCT
concept-1708	130	21	they	they	PRON
concept-1708	130	22	ultimately	ultimately	ADV
concept-1708	130	23	realized	realize	VERB
concept-1708	130	24	that	that	SCONJ
concept-1708	130	25	the	the	DET
concept-1708	130	26	degradation	degradation	NOUN
concept-1708	130	27	of	of	ADP
concept-1708	130	28	ecm	ecm	NOUN
concept-1708	130	29	is	be	AUX
concept-1708	130	30	positively	positively	ADV
concept-1708	130	31	correlated	correlate	VERB
concept-1708	130	32	to	to	ADP
concept-1708	130	33	heightened	heighten	VERB
concept-1708	130	34	interactions	interaction	NOUN
concept-1708	130	35	between	between	ADP
concept-1708	130	36	cells	cell	NOUN
concept-1708	130	37	,	,	PUNCT
concept-1708	130	38	as	as	SCONJ
concept-1708	130	39	shown	show	VERB
concept-1708	130	40	by	by	ADP
concept-1708	130	41	the	the	DET
concept-1708	130	42	diagram	diagram	NOUN
concept-1708	130	43	below	below	ADV
concept-1708	130	44	.	.	PUNCT
concept-1708	131	1	even	even	ADV
concept-1708	131	2	when	when	SCONJ
concept-1708	131	3	treating	treat	VERB
concept-1708	131	4	cells	cell	NOUN
concept-1708	131	5	as	as	ADP
concept-1708	131	6	individual	individual	ADJ
concept-1708	131	7	entities	entity	NOUN
concept-1708	131	8	,	,	PUNCT
concept-1708	131	9	the	the	DET
concept-1708	131	10	chemoattractant	chemoattractant	NOUN
concept-1708	131	11	gradients	gradient	NOUN
concept-1708	131	12	of	of	ADP
concept-1708	131	13	those	those	DET
concept-1708	131	14	cells	cell	NOUN
concept-1708	131	15	are	be	AUX
concept-1708	131	16	extremely	extremely	ADV
concept-1708	131	17	important	important	ADJ
concept-1708	131	18	in	in	ADP
concept-1708	131	19	the	the	DET
concept-1708	131	20	invasion	invasion	NOUN
concept-1708	131	21	process	process	NOUN
concept-1708	131	22	.	.	PUNCT
concept-1708	132	1	ao	ao	PROPN
concept-1708	132	2	et	et	PROPN
concept-1708	132	3	al	al	PROPN
concept-1708	132	4	.	.	PROPN
concept-1708	133	1	(	(	PUNCT
concept-1708	133	2	7	7	X
concept-1708	133	3	)	)	PUNCT
concept-1708	133	4	assumed	assume	VERB
concept-1708	133	5	that	that	SCONJ
concept-1708	133	6	cancer	cancer	NOUN
concept-1708	133	7	progression	progression	NOUN
concept-1708	133	8	is	be	AUX
concept-1708	133	9	a	a	DET
concept-1708	133	10	stochastic	stochastic	ADJ
concept-1708	133	11	process	process	NOUN
concept-1708	133	12	that	that	PRON
concept-1708	133	13	can	can	AUX
concept-1708	133	14	unintentionally	unintentionally	ADV
concept-1708	133	15	transition	transition	VERB
concept-1708	133	16	cells	cell	NOUN
concept-1708	133	17	from	from	ADP
concept-1708	133	18	one	one	NUM
concept-1708	133	19	stable	stable	ADJ
concept-1708	133	20	tumor	tumor	NOUN
concept-1708	133	21	site	site	NOUN
concept-1708	133	22	to	to	ADP
concept-1708	133	23	another	another	PRON
concept-1708	133	24	,	,	PUNCT
concept-1708	133	25	so	so	CCONJ
concept-1708	133	26	cancer	cancer	NOUN
concept-1708	133	27	can	can	AUX
concept-1708	133	28	spread	spread	VERB
concept-1708	133	29	unexpectedly	unexpectedly	ADV
concept-1708	133	30	and	and	CCONJ
concept-1708	133	31	drastically	drastically	ADV
concept-1708	133	32	even	even	ADV
concept-1708	133	33	if	if	SCONJ
concept-1708	133	34	it	it	PRON
concept-1708	133	35	has	have	AUX
concept-1708	133	36	remained	remain	VERB
concept-1708	133	37	in	in	ADP
concept-1708	133	38	one	one	NUM
concept-1708	133	39	spot	spot	NOUN
concept-1708	133	40	for	for	ADP
concept-1708	133	41	an	an	DET
concept-1708	133	42	extended	extended	ADJ
concept-1708	133	43	period	period	NOUN
concept-1708	133	44	of	of	ADP
concept-1708	133	45	time	time	NOUN
concept-1708	133	46	.	.	PUNCT
concept-1708	134	1	they	they	PRON
concept-1708	134	2	aimed	aim	VERB
concept-1708	134	3	to	to	PART
concept-1708	134	4	determine	determine	VERB
concept-1708	134	5	the	the	DET
concept-1708	134	6	cancer	cancer	NOUN
concept-1708	134	7	’s	’s	PART
concept-1708	134	8	endogenous	endogenous	ADJ
concept-1708	134	9	network	network	NOUN
concept-1708	134	10	by	by	ADP
concept-1708	134	11	mapping	map	VERB
concept-1708	134	12	the	the	DET
concept-1708	134	13	pathways	pathway	NOUN
concept-1708	134	14	and	and	CCONJ
concept-1708	134	15	modules	module	NOUN
concept-1708	134	16	that	that	PRON
concept-1708	134	17	the	the	DET
concept-1708	134	18	cancer	cancer	NOUN
concept-1708	134	19	and	and	CCONJ
concept-1708	134	20	other	other	ADJ
concept-1708	134	21	molecular	molecular	ADJ
concept-1708	134	22	and	and	CCONJ
concept-1708	134	23	cellular	cellular	ADJ
concept-1708	134	24	agents	agent	NOUN
concept-1708	134	25	may	may	AUX
concept-1708	134	26	develop	develop	VERB
concept-1708	134	27	.	.	PUNCT
concept-1708	135	1	they	they	PRON
concept-1708	135	2	hypothesized	hypothesize	VERB
concept-1708	135	3	that	that	SCONJ
concept-1708	135	4	there	there	PRON
concept-1708	135	5	is	be	VERB
concept-1708	135	6	at	at	ADV
concept-1708	135	7	least	least	ADJ
concept-1708	135	8	one	one	NUM
concept-1708	135	9	level	level	NOUN
concept-1708	135	10	of	of	ADP
concept-1708	135	11	virtually	virtually	ADV
concept-1708	135	12	independent	independent	ADJ
concept-1708	135	13	interaction	interaction	NOUN
concept-1708	135	14	between	between	ADP
concept-1708	135	15	genetic	genetic	ADJ
concept-1708	135	16	and	and	CCONJ
concept-1708	135	17	environmental	environmental	ADJ
concept-1708	135	18	factors	factor	NOUN
concept-1708	135	19	that	that	PRON
concept-1708	135	20	would	would	AUX
concept-1708	135	21	allow	allow	VERB
concept-1708	135	22	one	one	PRON
concept-1708	135	23	to	to	PART
concept-1708	135	24	map	map	VERB
concept-1708	135	25	the	the	DET
concept-1708	135	26	spread	spread	NOUN
concept-1708	135	27	of	of	ADP
concept-1708	135	28	a	a	DET
concept-1708	135	29	cancer	cancer	NOUN
concept-1708	135	30	.	.	PUNCT
concept-1708	136	1	ao	ao	PROPN
concept-1708	136	2	et	et	PROPN
concept-1708	136	3	al	al	PROPN
concept-1708	136	4	.	.	PROPN
concept-1708	136	5	began	begin	VERB
concept-1708	136	6	by	by	ADP
concept-1708	136	7	establishing	establish	VERB
concept-1708	136	8	the	the	DET
concept-1708	136	9	interactions	interaction	NOUN
concept-1708	136	10	between	between	ADP
concept-1708	136	11	endogenous	endogenous	ADJ
concept-1708	136	12	agents	agent	NOUN
concept-1708	136	13	—	—	PUNCT
concept-1708	136	14	ones	one	NOUN
concept-1708	136	15	that	that	PRON
concept-1708	136	16	contribute	contribute	VERB
concept-1708	136	17	to	to	ADP
concept-1708	136	18	cancer	cancer	NOUN
concept-1708	136	19	growth	growth	NOUN
concept-1708	136	20	in	in	ADP
concept-1708	136	21	the	the	DET
concept-1708	136	22	body	body	NOUN
concept-1708	136	23	—	—	PUNCT
concept-1708	136	24	and	and	CCONJ
concept-1708	136	25	the	the	DET
concept-1708	136	26	enzymes	enzyme	NOUN
concept-1708	136	27	plots	plot	NOUN
concept-1708	136	28	of	of	ADP
concept-1708	136	29	evolution	evolution	NOUN
concept-1708	136	30	of	of	ADP
concept-1708	136	31	cancer	cancer	NOUN
concept-1708	136	32	cells	cell	NOUN
concept-1708	136	33	as	as	SCONJ
concept-1708	136	34	they	they	PRON
concept-1708	136	35	invade	invade	VERB
concept-1708	136	36	the	the	DET
concept-1708	136	37	ecm	ecm	NOUN
concept-1708	136	38	(	(	PUNCT
concept-1708	136	39	9	9	NUM
concept-1708	136	40	)	)	PUNCT
concept-1708	136	41	    	    	SPACE
concept-1708	136	42	that	that	PRON
concept-1708	136	43	activate	activate	VERB
concept-1708	136	44	or	or	CCONJ
concept-1708	136	45	inhibit	inhibit	VERB
concept-1708	136	46	those	those	DET
concept-1708	136	47	agents	agent	NOUN
concept-1708	136	48	from	from	ADP
concept-1708	136	49	spreading	spread	VERB
concept-1708	136	50	through	through	ADP
concept-1708	136	51	the	the	DET
concept-1708	136	52	body	body	NOUN
concept-1708	136	53	(	(	PUNCT
concept-1708	136	54	7	7	NUM
concept-1708	136	55	)	)	PUNCT
concept-1708	136	56	.	.	PUNCT
concept-1708	137	1	they	they	PRON
concept-1708	137	2	focused	focus	VERB
concept-1708	137	3	their	their	PRON
concept-1708	137	4	study	study	NOUN
concept-1708	137	5	on	on	ADP
concept-1708	137	6	prostate	prostate	NOUN
concept-1708	137	7	cancer	cancer	NOUN
concept-1708	137	8	,	,	PUNCT
concept-1708	137	9	which	which	PRON
concept-1708	137	10	is	be	AUX
concept-1708	137	11	denoted	denote	VERB
concept-1708	137	12	by	by	ADP
concept-1708	137	13	the	the	DET
concept-1708	137	14	occurrence	occurrence	NOUN
concept-1708	137	15	of	of	ADP
concept-1708	137	16	androgen	androgen	NOUN
concept-1708	137	17	receptor	receptor	NOUN
concept-1708	137	18	(	(	PUNCT
concept-1708	137	19	ar	ar	NOUN
concept-1708	137	20	)	)	PUNCT
concept-1708	137	21	and	and	CCONJ
concept-1708	137	22	the	the	DET
concept-1708	137	23	insulin	insulin	NOUN
concept-1708	137	24	-	-	PUNCT
concept-1708	137	25	like	like	ADJ
concept-1708	137	26	growth	growth	NOUN
concept-1708	137	27	factor	factor	NOUN
concept-1708	137	28	receptor	receptor	NOUN
concept-1708	137	29	(	(	PUNCT
concept-1708	137	30	igf-1r	igf-1r	PROPN
concept-1708	137	31	)	)	PUNCT
concept-1708	137	32	in	in	ADP
concept-1708	137	33	the	the	DET
concept-1708	137	34	table	table	NOUN
concept-1708	137	35	below	below	ADV
concept-1708	137	36	.	.	PUNCT
concept-1708	138	1	table	table	NOUN
concept-1708	138	2	of	of	ADP
concept-1708	138	3	interactions	interaction	NOUN
concept-1708	138	4	among	among	ADP
concept-1708	138	5	cancer	cancer	NOUN
concept-1708	138	6	agents	agent	NOUN
concept-1708	138	7	from	from	ADP
concept-1708	138	8	targeted	target	VERB
concept-1708	138	9	pair	pair	NOUN
concept-1708	138	10	-	-	PUNCT
concept-1708	138	11	wise	wise	ADJ
concept-1708	138	12	experimental	experimental	ADJ
concept-1708	138	13	data	datum	NOUN
concept-1708	138	14	(	(	PUNCT
concept-1708	138	15	7	7	NUM
concept-1708	138	16	)	)	PUNCT
concept-1708	138	17	  	  	SPACE
concept-1708	138	18	directed	direct	VERB
concept-1708	138	19	graph	graph	NOUN
concept-1708	138	20	representation	representation	NOUN
concept-1708	138	21	of	of	ADP
concept-1708	138	22	the	the	DET
concept-1708	138	23	interactions	interaction	NOUN
concept-1708	138	24	from	from	ADP
concept-1708	138	25	the	the	DET
concept-1708	138	26	table	table	NOUN
concept-1708	138	27	above	above	ADV
concept-1708	138	28	(	(	PUNCT
concept-1708	138	29	7	7	X
concept-1708	138	30	)	)	PUNCT
concept-1708	138	31	they	they	PRON
concept-1708	138	32	then	then	ADV
concept-1708	138	33	formed	form	VERB
concept-1708	138	34	an	an	DET
concept-1708	138	35	equation	equation	NOUN
concept-1708	138	36	to	to	PART
concept-1708	138	37	represent	represent	VERB
concept-1708	138	38	the	the	DET
concept-1708	138	39	set	set	NOUN
concept-1708	138	40	of	of	ADP
concept-1708	138	41	stochastic	stochastic	ADJ
concept-1708	138	42	dynamics	dynamic	NOUN
concept-1708	138	43	found	find	VERB
concept-1708	138	44	in	in	ADP
concept-1708	138	45	this	this	DET
concept-1708	138	46	network	network	NOUN
concept-1708	138	47	:	:	PUNCT
concept-1708	138	48	dx	dx	PROPN
concept-1708	138	49	/	/	SYM
concept-1708	138	50	dt	dt	PROPN
concept-1708	138	51	=	=	SYM
concept-1708	138	52	f(x	f(x	PROPN
concept-1708	138	53	)	)	PUNCT
concept-1708	138	54	–	–	PUNCT
concept-1708	138	55	x	x	X
concept-1708	138	56	/	/	SYM
concept-1708	138	57	r	r	NOUN
concept-1708	138	58	+	+	NUM
concept-1708	138	59	ε(x	ε(x	NOUN
concept-1708	138	60	,	,	PUNCT
concept-1708	138	61	t	t	PROPN
concept-1708	138	62	)	)	PUNCT
concept-1708	138	63	,	,	PUNCT
concept-1708	138	64	which	which	PRON
concept-1708	138	65	shows	show	VERB
concept-1708	138	66	that	that	SCONJ
concept-1708	138	67	the	the	DET
concept-1708	138	68	deterministic	deterministic	ADJ
concept-1708	138	69	force	force	NOUN
concept-1708	138	70	f	f	PROPN
concept-1708	138	71	can	can	AUX
concept-1708	138	72	be	be	AUX
concept-1708	138	73	modeled	model	VERB
concept-1708	138	74	as	as	ADP
concept-1708	138	75	sigmoidal	sigmoidal	NOUN
concept-1708	138	76	(	(	PUNCT
concept-1708	138	77	s	s	NOUN
concept-1708	138	78	-	-	PUNCT
concept-1708	138	79	shaped	shaped	ADJ
concept-1708	138	80	)	)	PUNCT
concept-1708	138	81	functions	function	NOUN
concept-1708	138	82	between	between	ADP
concept-1708	138	83	0	0	NUM
concept-1708	138	84	and	and	CCONJ
concept-1708	138	85	1	1	NUM
concept-1708	138	86	(	(	PUNCT
concept-1708	138	87	7	7	NUM
concept-1708	138	88	)	)	PUNCT
concept-1708	138	89	.	.	PUNCT
concept-1708	139	1	they	they	PRON
concept-1708	139	2	also	also	ADV
concept-1708	139	3	defined	define	VERB
concept-1708	139	4	the	the	DET
concept-1708	139	5	equations	equation	NOUN
concept-1708	139	6	for	for	ADP
concept-1708	139	7	activation	activation	NOUN
concept-1708	139	8	,	,	PUNCT
concept-1708	139	9	fa(y	fa(y	PROPN
concept-1708	139	10	)	)	PUNCT
concept-1708	139	11	=	=	SYM
concept-1708	140	1	ayn/(1	ayn/(1	PROPN
concept-1708	140	2	+	+	NUM
concept-1708	140	3	ayn	ayn	PROPN
concept-1708	140	4	)	)	PUNCT
concept-1708	140	5	,	,	PUNCT
concept-1708	140	6	and	and	CCONJ
concept-1708	140	7	inhibition	inhibition	NOUN
concept-1708	140	8	,	,	PUNCT
concept-1708	140	9	fi(y	fi(y	NOUN
concept-1708	140	10	)	)	PUNCT
concept-1708	140	11	=	=	SYM
concept-1708	140	12	1	1	NUM
concept-1708	140	13	-	-	NUM
concept-1708	140	14	fa(y	fa(y	NOUN
concept-1708	140	15	)	)	PUNCT
concept-1708	140	16	=	=	SYM
concept-1708	141	1	1/(1	1/(1	NUM
concept-1708	141	2	+	+	NUM
concept-1708	141	3	ayn	ayn	PROPN
concept-1708	141	4	)	)	PUNCT
concept-1708	141	5	,	,	PUNCT
concept-1708	141	6	where	where	SCONJ
concept-1708	141	7	the	the	DET
concept-1708	141	8	variables	variable	NOUN
concept-1708	141	9	are	be	AUX
concept-1708	141	10	normalized	normalize	VERB
concept-1708	141	11	to	to	ADP
concept-1708	141	12	the	the	DET
concept-1708	141	13	values	value	NOUN
concept-1708	141	14	a	a	DET
concept-1708	141	15	=	=	SYM
concept-1708	141	16	10	10	NUM
concept-1708	141	17	and	and	CCONJ
concept-1708	141	18	n	n	CCONJ
concept-1708	141	19	=	=	SYM
concept-1708	141	20	3	3	NUM
concept-1708	141	21	and	and	CCONJ
concept-1708	141	22	the	the	DET
concept-1708	141	23	degradation	degradation	NOUN
concept-1708	141	24	time	time	NOUN
concept-1708	141	25	r	r	NOUN
concept-1708	141	26	is	be	AUX
concept-1708	141	27	constant	constant	ADJ
concept-1708	141	28	.	.	PUNCT
concept-1708	142	1	they	they	PRON
concept-1708	142	2	modeled	model	VERB
concept-1708	142	3	this	this	PRON
concept-1708	142	4	using	use	VERB
concept-1708	142	5	a	a	DET
concept-1708	142	6	diffusion	diffusion	NOUN
concept-1708	142	7	matrix	matrix	NOUN
concept-1708	142	8	d	d	ADP
concept-1708	142	9	that	that	SCONJ
concept-1708	142	10	they	they	PRON
concept-1708	142	11	chose	choose	VERB
concept-1708	142	12	to	to	PART
concept-1708	142	13	be	be	AUX
concept-1708	142	14	diagonal	diagonal	ADJ
concept-1708	142	15	to	to	PART
concept-1708	142	16	simplify	simplify	VERB
concept-1708	142	17	the	the	DET
concept-1708	142	18	calculations	calculation	NOUN
concept-1708	142	19	.	.	PUNCT
concept-1708	143	1	ao	ao	PROPN
concept-1708	143	2	et	et	PROPN
concept-1708	143	3	al	al	PROPN
concept-1708	143	4	.	.	PROPN
concept-1708	143	5	assumed	assume	VERB
concept-1708	143	6	that	that	SCONJ
concept-1708	143	7	there	there	PRON
concept-1708	143	8	would	would	AUX
concept-1708	143	9	be	be	AUX
concept-1708	143	10	multiple	multiple	ADJ
concept-1708	143	11	stable	stable	ADJ
concept-1708	143	12	states	state	NOUN
concept-1708	143	13	and	and	CCONJ
concept-1708	143	14	therefore	therefore	ADV
concept-1708	143	15	there	there	PRON
concept-1708	143	16	would	would	AUX
concept-1708	143	17	be	be	AUX
concept-1708	143	18	3	3	NUM
concept-1708	143	19	possible	possible	ADJ
concept-1708	143	20	outcomes	outcome	NOUN
concept-1708	143	21	of	of	ADP
concept-1708	143	22	interactions	interaction	NOUN
concept-1708	143	23	with	with	ADP
concept-1708	143	24	endogenous	endogenous	ADJ
concept-1708	143	25	agents	agent	NOUN
concept-1708	143	26	:	:	PUNCT
concept-1708	143	27	states	state	VERB
concept-1708	143	28	that	that	PRON
concept-1708	143	29	parallel	parallel	VERB
concept-1708	143	30	the	the	DET
concept-1708	143	31	healthy	healthy	ADJ
concept-1708	143	32	ones	one	NOUN
concept-1708	143	33	under	under	ADP
concept-1708	143	34	normal	normal	ADJ
concept-1708	143	35	conditions	condition	NOUN
concept-1708	143	36	,	,	PUNCT
concept-1708	143	37	stressful	stressful	ADJ
concept-1708	143	38	states	state	NOUN
concept-1708	143	39	that	that	PRON
concept-1708	143	40	may	may	AUX
concept-1708	143	41	lead	lead	VERB
concept-1708	143	42	to	to	ADP
concept-1708	143	43	tumor	tumor	NOUN
concept-1708	143	44	growth	growth	NOUN
concept-1708	143	45	,	,	PUNCT
concept-1708	143	46	and	and	CCONJ
concept-1708	143	47	ones	one	NOUN
concept-1708	143	48	in	in	ADP
concept-1708	143	49	the	the	DET
concept-1708	143	50	tumor	tumor	NOUN
concept-1708	143	51	growth	growth	NOUN
concept-1708	143	52	phase	phase	NOUN
concept-1708	143	53	(	(	PUNCT
concept-1708	143	54	7	7	NUM
concept-1708	143	55	)	)	PUNCT
concept-1708	143	56	.	.	PUNCT
concept-1708	144	1	the	the	DET
concept-1708	144	2	values	value	NOUN
concept-1708	144	3	in	in	ADP
concept-1708	144	4	the	the	DET
concept-1708	144	5	table	table	NOUN
concept-1708	144	6	below	below	ADV
concept-1708	144	7	are	be	AUX
concept-1708	144	8	given	give	VERB
concept-1708	144	9	in	in	ADP
concept-1708	144	10	terms	term	NOUN
concept-1708	144	11	of	of	ADP
concept-1708	144	12	their	their	PRON
concept-1708	144	13	maximum	maximum	ADJ
concept-1708	144	14	activity	activity	NOUN
concept-1708	144	15	.	.	PUNCT
concept-1708	144	16	  	  	SPACE
concept-1708	144	17	table	table	NOUN
concept-1708	144	18	showing	show	VERB
concept-1708	144	19	endogenous	endogenous	ADJ
concept-1708	144	20	agent	agent	NOUN
concept-1708	144	21	activity	activity	NOUN
concept-1708	144	22	in	in	ADP
concept-1708	144	23	3	3	NUM
concept-1708	144	24	possible	possible	ADJ
concept-1708	144	25	states	state	NOUN
concept-1708	144	26	of	of	ADP
concept-1708	144	27	cancer	cancer	NOUN
concept-1708	144	28	growth	growth	NOUN
concept-1708	144	29	(	(	PUNCT
concept-1708	144	30	7	7	NUM
concept-1708	144	31	)	)	PUNCT
concept-1708	144	32	ao	ao	NOUN
concept-1708	144	33	et	et	PROPN
concept-1708	144	34	al	al	PROPN
concept-1708	144	35	.	.	PROPN
concept-1708	144	36	stressed	stress	VERB
concept-1708	144	37	the	the	DET
concept-1708	144	38	need	need	NOUN
concept-1708	144	39	for	for	ADP
concept-1708	144	40	a	a	DET
concept-1708	144	41	minimum	minimum	ADJ
concept-1708	144	42	amount	amount	NOUN
concept-1708	144	43	of	of	ADP
concept-1708	144	44	endogenous	endogenous	ADJ
concept-1708	144	45	agents	agent	NOUN
concept-1708	144	46	(	(	PUNCT
concept-1708	144	47	37	37	NUM
concept-1708	144	48	in	in	ADP
concept-1708	144	49	their	their	PRON
concept-1708	144	50	model	model	NOUN
concept-1708	144	51	for	for	ADP
concept-1708	144	52	prostate	prostate	NOUN
concept-1708	144	53	cancer	cancer	NOUN
concept-1708	144	54	)	)	PUNCT
concept-1708	144	55	in	in	ADP
concept-1708	144	56	order	order	NOUN
concept-1708	144	57	for	for	SCONJ
concept-1708	144	58	cancer	cancer	NOUN
concept-1708	144	59	to	to	PART
concept-1708	144	60	spread	spread	VERB
concept-1708	144	61	.	.	PUNCT
concept-1708	145	1	they	they	PRON
concept-1708	145	2	noted	note	VERB
concept-1708	145	3	that	that	SCONJ
concept-1708	145	4	the	the	DET
concept-1708	145	5	table	table	NOUN
concept-1708	145	6	of	of	ADP
concept-1708	145	7	activity	activity	NOUN
concept-1708	145	8	above	above	ADV
concept-1708	145	9	indicates	indicate	VERB
concept-1708	145	10	that	that	SCONJ
concept-1708	145	11	there	there	PRON
concept-1708	145	12	is	be	VERB
concept-1708	145	13	a	a	DET
concept-1708	145	14	limited	limited	ADJ
concept-1708	145	15	probability	probability	NOUN
concept-1708	145	16	that	that	SCONJ
concept-1708	145	17	cancer	cancer	NOUN
concept-1708	145	18	will	will	AUX
concept-1708	145	19	occur	occur	VERB
concept-1708	145	20	spontaneously	spontaneously	ADV
concept-1708	145	21	,	,	PUNCT
concept-1708	145	22	even	even	ADV
concept-1708	145	23	without	without	ADP
concept-1708	145	24	mutations	mutation	NOUN
concept-1708	145	25	or	or	CCONJ
concept-1708	145	26	other	other	ADJ
concept-1708	145	27	debilitating	debilitate	VERB
concept-1708	145	28	factors	factor	NOUN
concept-1708	145	29	,	,	PUNCT
concept-1708	145	30	and	and	CCONJ
concept-1708	145	31	that	that	SCONJ
concept-1708	145	32	with	with	ADP
concept-1708	145	33	further	further	ADJ
concept-1708	145	34	experimental	experimental	ADJ
concept-1708	145	35	observation	observation	NOUN
concept-1708	145	36	,	,	PUNCT
concept-1708	145	37	a	a	DET
concept-1708	145	38	more	more	ADV
concept-1708	145	39	accurate	accurate	ADJ
concept-1708	145	40	quantitative	quantitative	ADJ
concept-1708	145	41	model	model	NOUN
concept-1708	145	42	of	of	ADP
concept-1708	145	43	cancer	cancer	NOUN
concept-1708	145	44	genesis	genesis	NOUN
concept-1708	145	45	and	and	CCONJ
concept-1708	145	46	progression	progression	NOUN
concept-1708	145	47	using	use	VERB
concept-1708	145	48	endogenous	endogenous	ADJ
concept-1708	145	49	agents	agent	NOUN
concept-1708	145	50	is	be	AUX
concept-1708	145	51	possible	possible	ADJ
concept-1708	145	52	(	(	PUNCT
concept-1708	145	53	7	7	NUM
concept-1708	145	54	)	)	PUNCT
concept-1708	145	55	.	.	PUNCT
concept-1708	145	56	  	  	SPACE
concept-1708	146	1	iii	iii	X
concept-1708	146	2	.	.	PUNCT
concept-1708	146	3	evaluation	evaluation	NOUN
concept-1708	146	4	:	:	PUNCT
concept-1708	146	5	disadvantages	disadvantage	VERB
concept-1708	146	6	there	there	PRON
concept-1708	146	7	are	be	VERB
concept-1708	146	8	aspects	aspect	NOUN
concept-1708	146	9	of	of	ADP
concept-1708	146	10	each	each	PRON
concept-1708	146	11	of	of	ADP
concept-1708	146	12	these	these	DET
concept-1708	146	13	studies	study	NOUN
concept-1708	146	14	that	that	PRON
concept-1708	146	15	can	can	AUX
concept-1708	146	16	be	be	AUX
concept-1708	146	17	helpful	helpful	ADJ
concept-1708	146	18	in	in	ADP
concept-1708	146	19	future	future	ADJ
concept-1708	146	20	prognoses	prognosis	NOUN
concept-1708	146	21	of	of	ADP
concept-1708	146	22	cancer	cancer	NOUN
concept-1708	146	23	,	,	PUNCT
concept-1708	146	24	but	but	CCONJ
concept-1708	146	25	there	there	PRON
concept-1708	146	26	are	be	VERB
concept-1708	146	27	also	also	ADV
concept-1708	146	28	many	many	ADJ
concept-1708	146	29	disadvantages	disadvantage	NOUN
concept-1708	146	30	.	.	PUNCT
concept-1708	147	1	the	the	DET
concept-1708	147	2	studies	study	NOUN
concept-1708	147	3	by	by	ADP
concept-1708	147	4	newton	newton	PROPN
concept-1708	147	5	et	et	PROPN
concept-1708	147	6	al	al	PROPN
concept-1708	147	7	.	.	PROPN
concept-1708	147	8	(	(	PUNCT
concept-1708	147	9	8)	8)	NUM
concept-1708	147	10	and	and	CCONJ
concept-1708	147	11	ao	ao	NOUN
concept-1708	147	12	et	et	PROPN
concept-1708	147	13	al	al	PROPN
concept-1708	147	14	.	.	PROPN
concept-1708	148	1	(	(	PUNCT
concept-1708	148	2	7	7	X
concept-1708	148	3	)	)	PUNCT
concept-1708	148	4	considered	consider	VERB
concept-1708	148	5	only	only	ADV
concept-1708	148	6	specific	specific	ADJ
concept-1708	148	7	types	type	NOUN
concept-1708	148	8	of	of	ADP
concept-1708	148	9	cancer	cancer	NOUN
concept-1708	148	10	:	:	PUNCT
concept-1708	148	11	lung	lung	NOUN
concept-1708	148	12	and	and	CCONJ
concept-1708	148	13	prostate	prostate	NOUN
concept-1708	148	14	,	,	PUNCT
concept-1708	148	15	respectively	respectively	ADV
concept-1708	148	16	.	.	PUNCT
concept-1708	149	1	while	while	SCONJ
concept-1708	149	2	both	both	DET
concept-1708	149	3	studies	study	NOUN
concept-1708	149	4	presented	present	VERB
concept-1708	149	5	a	a	DET
concept-1708	149	6	rough	rough	ADJ
concept-1708	149	7	network	network	NOUN
concept-1708	149	8	of	of	ADP
concept-1708	149	9	ctcs	ctcs	NOUN
concept-1708	149	10	in	in	ADP
concept-1708	149	11	the	the	DET
concept-1708	149	12	body	body	NOUN
concept-1708	149	13	,	,	PUNCT
concept-1708	149	14	one	one	PRON
concept-1708	149	15	ca	can	AUX
concept-1708	149	16	n’t	not	PART
concept-1708	149	17	assume	assume	VERB
concept-1708	149	18	that	that	SCONJ
concept-1708	149	19	the	the	DET
concept-1708	149	20	pathways	pathway	NOUN
concept-1708	149	21	they	they	PRON
concept-1708	149	22	discovered	discover	VERB
concept-1708	149	23	would	would	AUX
concept-1708	149	24	be	be	AUX
concept-1708	149	25	applicable	applicable	ADJ
concept-1708	149	26	to	to	ADP
concept-1708	149	27	every	every	DET
concept-1708	149	28	cancer	cancer	NOUN
concept-1708	149	29	possible	possible	ADJ
concept-1708	149	30	.	.	PUNCT
concept-1708	150	1	there	there	PRON
concept-1708	150	2	are	be	VERB
concept-1708	150	3	many	many	ADJ
concept-1708	150	4	environmental	environmental	ADJ
concept-1708	150	5	factors	factor	NOUN
concept-1708	150	6	that	that	PRON
concept-1708	150	7	could	could	AUX
concept-1708	150	8	affect	affect	VERB
concept-1708	150	9	other	other	ADJ
concept-1708	150	10	types	type	NOUN
concept-1708	150	11	of	of	ADP
concept-1708	150	12	cancer	cancer	NOUN
concept-1708	150	13	differently	differently	ADV
concept-1708	150	14	,	,	PUNCT
concept-1708	150	15	like	like	ADP
concept-1708	150	16	proximity	proximity	NOUN
concept-1708	150	17	to	to	ADP
concept-1708	150	18	other	other	ADJ
concept-1708	150	19	organs	organ	NOUN
concept-1708	150	20	.	.	PUNCT
concept-1708	151	1	one	one	NUM
concept-1708	151	2	major	major	ADJ
concept-1708	151	3	drawback	drawback	NOUN
concept-1708	151	4	of	of	ADP
concept-1708	151	5	the	the	DET
concept-1708	151	6	divoli	divoli	NOUN
concept-1708	151	7	et	et	PROPN
concept-1708	151	8	al	al	PROPN
concept-1708	151	9	.	.	PROPN
concept-1708	152	1	(	(	PUNCT
concept-1708	152	2	5	5	X
concept-1708	152	3	)	)	PUNCT
concept-1708	152	4	study	study	NOUN
concept-1708	152	5	was	be	AUX
concept-1708	152	6	that	that	SCONJ
concept-1708	152	7	they	they	PRON
concept-1708	152	8	did	do	AUX
concept-1708	152	9	not	not	PART
concept-1708	152	10	use	use	VERB
concept-1708	152	11	any	any	DET
concept-1708	152	12	scientific	scientific	ADJ
concept-1708	152	13	or	or	CCONJ
concept-1708	152	14	experimental	experimental	ADJ
concept-1708	152	15	data	datum	NOUN
concept-1708	152	16	—	—	PUNCT
concept-1708	152	17	their	their	PRON
concept-1708	152	18	entire	entire	ADJ
concept-1708	152	19	study	study	NOUN
concept-1708	152	20	is	be	AUX
concept-1708	152	21	based	base	VERB
concept-1708	152	22	on	on	ADP
concept-1708	152	23	the	the	DET
concept-1708	152	24	opinions	opinion	NOUN
concept-1708	152	25	of	of	ADP
concept-1708	152	26	28	28	NUM
concept-1708	152	27	humans	human	NOUN
concept-1708	152	28	.	.	PUNCT
concept-1708	153	1	while	while	SCONJ
concept-1708	153	2	these	these	DET
concept-1708	153	3	humans	human	NOUN
concept-1708	153	4	were	be	AUX
concept-1708	153	5	experts	expert	NOUN
concept-1708	153	6	in	in	ADP
concept-1708	153	7	their	their	PRON
concept-1708	153	8	fields	field	NOUN
concept-1708	153	9	,	,	PUNCT
concept-1708	153	10	the	the	DET
concept-1708	153	11	sample	sample	NOUN
concept-1708	153	12	size	size	NOUN
concept-1708	153	13	was	be	AUX
concept-1708	153	14	extremely	extremely	ADV
concept-1708	153	15	small	small	ADJ
concept-1708	153	16	compared	compare	VERB
concept-1708	153	17	to	to	ADP
concept-1708	153	18	the	the	DET
concept-1708	153	19	different	different	ADJ
concept-1708	153	20	amounts	amount	NOUN
concept-1708	153	21	of	of	ADP
concept-1708	153	22	cancerous	cancerous	ADJ
concept-1708	153	23	and	and	CCONJ
concept-1708	153	24	metastatic	metastatic	ADJ
concept-1708	153	25	situations	situation	NOUN
concept-1708	153	26	that	that	PRON
concept-1708	153	27	can	can	AUX
concept-1708	153	28	arise	arise	VERB
concept-1708	153	29	.	.	PUNCT
concept-1708	154	1	ramis	ramis	PROPN
concept-1708	154	2	-	-	PUNCT
concept-1708	154	3	conde	conde	PROPN
concept-1708	154	4	et	et	PROPN
concept-1708	154	5	al	al	PROPN
concept-1708	154	6	.	.	PROPN
concept-1708	155	1	(	(	PUNCT
concept-1708	155	2	9	9	X
concept-1708	155	3	)	)	PUNCT
concept-1708	155	4	accounted	account	VERB
concept-1708	155	5	for	for	ADP
concept-1708	155	6	many	many	ADJ
concept-1708	155	7	factors	factor	NOUN
concept-1708	155	8	that	that	PRON
concept-1708	155	9	could	could	AUX
concept-1708	155	10	inhibit	inhibit	VERB
concept-1708	155	11	the	the	DET
concept-1708	155	12	progression	progression	NOUN
concept-1708	155	13	of	of	ADP
concept-1708	155	14	cancerous	cancerous	ADJ
concept-1708	155	15	cells	cell	NOUN
concept-1708	155	16	through	through	ADP
concept-1708	155	17	the	the	DET
concept-1708	155	18	body	body	NOUN
concept-1708	155	19	,	,	PUNCT
concept-1708	155	20	but	but	CCONJ
concept-1708	155	21	their	their	PRON
concept-1708	155	22	study	study	NOUN
concept-1708	155	23	did	do	AUX
concept-1708	155	24	not	not	PART
concept-1708	155	25	include	include	VERB
concept-1708	155	26	any	any	DET
concept-1708	155	27	information	information	NOUN
concept-1708	155	28	on	on	ADP
concept-1708	155	29	the	the	DET
concept-1708	155	30	timeframe	timeframe	NOUN
concept-1708	155	31	of	of	ADP
concept-1708	155	32	metastasis	metastasis	NOUN
concept-1708	155	33	,	,	PUNCT
concept-1708	155	34	where	where	SCONJ
concept-1708	155	35	the	the	DET
concept-1708	155	36	metastases	metastasis	NOUN
concept-1708	155	37	would	would	AUX
concept-1708	155	38	occur	occur	VERB
concept-1708	155	39	,	,	PUNCT
concept-1708	155	40	or	or	CCONJ
concept-1708	155	41	the	the	DET
concept-1708	155	42	amount	amount	NOUN
concept-1708	155	43	of	of	ADP
concept-1708	155	44	metastasis	metastasis	NOUN
concept-1708	155	45	locations	location	NOUN
concept-1708	155	46	that	that	PRON
concept-1708	155	47	are	be	AUX
concept-1708	155	48	possible	possible	ADJ
concept-1708	155	49	.	.	PUNCT
concept-1708	156	1	liotta	liotta	PROPN
concept-1708	156	2	et	et	PROPN
concept-1708	156	3	al	al	PROPN
concept-1708	156	4	.	.	PROPN
concept-1708	157	1	(	(	PUNCT
concept-1708	157	2	14	14	NUM
concept-1708	157	3	)	)	PUNCT
concept-1708	157	4	also	also	ADV
concept-1708	157	5	neglected	neglect	VERB
concept-1708	157	6	to	to	PART
concept-1708	157	7	identify	identify	VERB
concept-1708	157	8	any	any	DET
concept-1708	157	9	metastatic	metastatic	ADJ
concept-1708	157	10	pathways	pathway	NOUN
concept-1708	157	11	or	or	CCONJ
concept-1708	157	12	networks	network	NOUN
concept-1708	157	13	.	.	PUNCT
concept-1708	158	1	iv	iv	X
concept-1708	158	2	.	.	PUNCT
concept-1708	158	3	conclusion	conclusion	NOUN
concept-1708	158	4	through	through	ADP
concept-1708	158	5	this	this	DET
concept-1708	158	6	research	research	NOUN
concept-1708	158	7	,	,	PUNCT
concept-1708	158	8	over	over	ADP
concept-1708	158	9	ten	ten	NUM
concept-1708	158	10	different	different	ADJ
concept-1708	158	11	mathematical	mathematical	ADJ
concept-1708	158	12	models	model	NOUN
concept-1708	158	13	of	of	ADP
concept-1708	158	14	cancer	cancer	NOUN
concept-1708	158	15	were	be	AUX
concept-1708	158	16	considered	consider	VERB
concept-1708	158	17	,	,	PUNCT
concept-1708	158	18	including	include	VERB
concept-1708	158	19	not	not	PART
concept-1708	158	20	just	just	ADV
concept-1708	158	21	the	the	DET
concept-1708	158	22	markov	markov	NOUN
concept-1708	158	23	chains	chain	NOUN
concept-1708	158	24	and	and	CCONJ
concept-1708	158	25	partial	partial	ADJ
concept-1708	158	26	differential	differential	NOUN
concept-1708	158	27	equations	equation	NOUN
concept-1708	158	28	mentioned	mention	VERB
concept-1708	158	29	here	here	ADV
concept-1708	158	30	,	,	PUNCT
concept-1708	158	31	but	but	CCONJ
concept-1708	158	32	also	also	ADV
concept-1708	158	33	ordinary	ordinary	ADJ
concept-1708	158	34	differential	differential	ADJ
concept-1708	158	35	equations	equation	NOUN
concept-1708	158	36	(	(	PUNCT
concept-1708	158	37	6	6	NUM
concept-1708	158	38	)	)	PUNCT
concept-1708	158	39	,	,	PUNCT
concept-1708	158	40	cellular	cellular	ADJ
concept-1708	158	41	automata	automata	NOUN
concept-1708	158	42	(	(	PUNCT
concept-1708	158	43	10	10	NUM
concept-1708	158	44	)	)	PUNCT
concept-1708	158	45	,	,	PUNCT
concept-1708	158	46	least	least	ADJ
concept-1708	158	47	squares	square	NOUN
concept-1708	158	48	and	and	CCONJ
concept-1708	158	49	time	time	NOUN
concept-1708	158	50	-	-	PUNCT
concept-1708	158	51	branching	branch	VERB
concept-1708	158	52	(	(	PUNCT
concept-1708	158	53	4	4	NUM
concept-1708	158	54	)	)	PUNCT
concept-1708	158	55	,	,	PUNCT
concept-1708	158	56	and	and	CCONJ
concept-1708	158	57	graph	graph	NOUN
concept-1708	158	58	evolution	evolution	NOUN
concept-1708	158	59	(	(	PUNCT
concept-1708	158	60	11	11	NUM
concept-1708	158	61	)	)	PUNCT
concept-1708	158	62	,	,	PUNCT
concept-1708	158	63	among	among	ADP
concept-1708	158	64	others	other	NOUN
concept-1708	158	65	.	.	PUNCT
concept-1708	159	1	the	the	DET
concept-1708	159	2	amount	amount	NOUN
concept-1708	159	3	of	of	ADP
concept-1708	159	4	data	datum	NOUN
concept-1708	159	5	on	on	ADP
concept-1708	159	6	the	the	DET
concept-1708	159	7	subject	subject	NOUN
concept-1708	159	8	seems	seem	VERB
concept-1708	159	9	overwhelming	overwhelming	ADJ
concept-1708	159	10	,	,	PUNCT
concept-1708	159	11	but	but	CCONJ
concept-1708	159	12	it	it	PRON
concept-1708	159	13	becomes	become	VERB
concept-1708	159	14	clear	clear	ADJ
concept-1708	159	15	why	why	SCONJ
concept-1708	159	16	such	such	DET
concept-1708	159	17	a	a	DET
concept-1708	159	18	large	large	ADJ
concept-1708	159	19	number	number	NOUN
concept-1708	159	20	and	and	CCONJ
concept-1708	159	21	different	different	ADJ
concept-1708	159	22	types	type	NOUN
concept-1708	159	23	of	of	ADP
concept-1708	159	24	studies	study	NOUN
concept-1708	159	25	are	be	AUX
concept-1708	159	26	necessary	necessary	ADJ
concept-1708	159	27	after	after	ADP
concept-1708	159	28	learning	learn	VERB
concept-1708	159	29	more	more	ADJ
concept-1708	159	30	about	about	ADP
concept-1708	159	31	the	the	DET
concept-1708	159	32	process	process	NOUN
concept-1708	159	33	and	and	CCONJ
concept-1708	159	34	factors	factor	NOUN
concept-1708	159	35	of	of	ADP
concept-1708	159	36	metastasis	metastasis	NOUN
concept-1708	159	37	.	.	PUNCT
concept-1708	160	1	since	since	SCONJ
concept-1708	160	2	metastasis	metastasis	NOUN
concept-1708	160	3	is	be	AUX
concept-1708	160	4	such	such	DET
concept-1708	160	5	a	a	DET
concept-1708	160	6	multi	multi	ADJ
concept-1708	160	7	-	-	ADJ
concept-1708	160	8	faceted	faceted	ADJ
concept-1708	160	9	,	,	PUNCT
concept-1708	160	10	complex	complex	ADJ
concept-1708	160	11	process	process	NOUN
concept-1708	160	12	with	with	ADP
concept-1708	160	13	so	so	ADV
concept-1708	160	14	many	many	ADJ
concept-1708	160	15	factors	factor	NOUN
concept-1708	160	16	contributing	contribute	VERB
concept-1708	160	17	to	to	ADP
concept-1708	160	18	its	its	PRON
concept-1708	160	19	progression	progression	NOUN
concept-1708	160	20	,	,	PUNCT
concept-1708	160	21	it	it	PRON
concept-1708	160	22	would	would	AUX
concept-1708	160	23	be	be	AUX
concept-1708	160	24	extremely	extremely	ADV
concept-1708	160	25	difficult	difficult	ADJ
concept-1708	160	26	to	to	PART
concept-1708	160	27	attempt	attempt	VERB
concept-1708	160	28	to	to	PART
concept-1708	160	29	create	create	VERB
concept-1708	160	30	one	one	NUM
concept-1708	160	31	model	model	NOUN
concept-1708	160	32	to	to	PART
concept-1708	160	33	determine	determine	VERB
concept-1708	160	34	metastatic	metastatic	ADJ
concept-1708	160	35	spread	spread	NOUN
concept-1708	160	36	of	of	ADP
concept-1708	160	37	all	all	DET
concept-1708	160	38	cancers	cancer	NOUN
concept-1708	160	39	and	and	CCONJ
concept-1708	160	40	take	take	VERB
concept-1708	160	41	into	into	ADP
concept-1708	160	42	account	account	NOUN
concept-1708	160	43	every	every	DET
concept-1708	160	44	possible	possible	ADJ
concept-1708	160	45	scenario	scenario	NOUN
concept-1708	160	46	.	.	PUNCT
concept-1708	161	1	in	in	ADP
concept-1708	161	2	the	the	DET
concept-1708	161	3	past	past	ADJ
concept-1708	161	4	few	few	ADJ
concept-1708	161	5	decades	decade	NOUN
concept-1708	161	6	,	,	PUNCT
concept-1708	161	7	researchers	researcher	NOUN
concept-1708	161	8	have	have	AUX
concept-1708	161	9	developed	develop	VERB
concept-1708	161	10	studies	study	NOUN
concept-1708	161	11	on	on	ADP
concept-1708	161	12	different	different	ADJ
concept-1708	161	13	aspects	aspect	NOUN
concept-1708	161	14	of	of	ADP
concept-1708	161	15	the	the	DET
concept-1708	161	16	metastasis	metastasis	NOUN
concept-1708	161	17	dilemma	dilemma	NOUN
concept-1708	161	18	,	,	PUNCT
concept-1708	161	19	such	such	ADJ
concept-1708	161	20	as	as	ADP
concept-1708	161	21	how	how	SCONJ
concept-1708	161	22	cancer	cancer	NOUN
concept-1708	161	23	leaves	leave	VERB
concept-1708	161	24	the	the	DET
concept-1708	161	25	primary	primary	ADJ
concept-1708	161	26	tumor	tumor	NOUN
concept-1708	161	27	,	,	PUNCT
concept-1708	161	28	how	how	SCONJ
concept-1708	161	29	it	it	PRON
concept-1708	161	30	travels	travel	VERB
concept-1708	161	31	through	through	ADP
concept-1708	161	32	the	the	DET
concept-1708	161	33	body	body	NOUN
concept-1708	161	34	,	,	PUNCT
concept-1708	161	35	factors	factor	NOUN
concept-1708	161	36	in	in	ADP
concept-1708	161	37	the	the	DET
concept-1708	161	38	body	body	NOUN
concept-1708	161	39	and	and	CCONJ
concept-1708	161	40	cancer	cancer	NOUN
concept-1708	161	41	cells	cell	NOUN
concept-1708	161	42	that	that	PRON
concept-1708	161	43	prohibit	prohibit	VERB
concept-1708	161	44	it	it	PRON
concept-1708	161	45	from	from	ADP
concept-1708	161	46	surviving	survive	VERB
concept-1708	161	47	a	a	DET
concept-1708	161	48	journey	journey	NOUN
concept-1708	161	49	,	,	PUNCT
concept-1708	161	50	factors	factor	NOUN
concept-1708	161	51	that	that	PRON
concept-1708	161	52	allow	allow	VERB
concept-1708	161	53	cancer	cancer	NOUN
concept-1708	161	54	to	to	PART
concept-1708	161	55	settle	settle	VERB
concept-1708	161	56	in	in	ADP
concept-1708	161	57	a	a	DET
concept-1708	161	58	new	new	ADJ
concept-1708	161	59	area	area	NOUN
concept-1708	161	60	,	,	PUNCT
concept-1708	161	61	and	and	CCONJ
concept-1708	161	62	what	what	DET
concept-1708	161	63	stages	stage	NOUN
concept-1708	161	64	are	be	AUX
concept-1708	161	65	included	include	VERB
concept-1708	161	66	in	in	ADP
concept-1708	161	67	the	the	DET
concept-1708	161	68	metastatic	metastatic	ADJ
concept-1708	161	69	process	process	NOUN
concept-1708	161	70	.	.	PUNCT
concept-1708	162	1	since	since	SCONJ
concept-1708	162	2	it	it	PRON
concept-1708	162	3	is	be	AUX
concept-1708	162	4	so	so	ADV
concept-1708	162	5	problematic	problematic	ADJ
concept-1708	162	6	to	to	PART
concept-1708	162	7	establish	establish	VERB
concept-1708	162	8	a	a	DET
concept-1708	162	9	universal	universal	ADJ
concept-1708	162	10	model	model	NOUN
concept-1708	162	11	,	,	PUNCT
concept-1708	162	12	it	it	PRON
concept-1708	162	13	is	be	AUX
concept-1708	162	14	helpful	helpful	ADJ
concept-1708	162	15	to	to	PART
concept-1708	162	16	have	have	VERB
concept-1708	162	17	models	model	NOUN
concept-1708	162	18	on	on	ADP
concept-1708	162	19	so	so	ADV
concept-1708	162	20	  	  	SPACE
concept-1708	162	21	many	many	ADJ
concept-1708	162	22	different	different	ADJ
concept-1708	162	23	stages	stage	NOUN
concept-1708	162	24	of	of	ADP
concept-1708	162	25	the	the	DET
concept-1708	162	26	disease	disease	NOUN
concept-1708	162	27	that	that	PRON
concept-1708	162	28	can	can	AUX
concept-1708	162	29	be	be	AUX
concept-1708	162	30	combined	combine	VERB
concept-1708	162	31	to	to	PART
concept-1708	162	32	determine	determine	VERB
concept-1708	162	33	an	an	DET
concept-1708	162	34	individual	individual	ADJ
concept-1708	162	35	cancer	cancer	NOUN
concept-1708	162	36	’s	’s	PART
concept-1708	162	37	progression	progression	NOUN
concept-1708	162	38	and	and	CCONJ
concept-1708	162	39	decide	decide	VERB
concept-1708	162	40	the	the	DET
concept-1708	162	41	best	good	ADJ
concept-1708	162	42	course	course	NOUN
concept-1708	162	43	of	of	ADP
concept-1708	162	44	treatment	treatment	NOUN
concept-1708	162	45	for	for	ADP
concept-1708	162	46	that	that	DET
concept-1708	162	47	person	person	NOUN
concept-1708	162	48	.	.	PUNCT
concept-1708	163	1	ultimately	ultimately	ADV
concept-1708	163	2	,	,	PUNCT
concept-1708	163	3	the	the	DET
concept-1708	163	4	largest	large	ADJ
concept-1708	163	5	benefit	benefit	NOUN
concept-1708	163	6	of	of	ADP
concept-1708	163	7	these	these	DET
concept-1708	163	8	models	model	NOUN
concept-1708	163	9	is	be	AUX
concept-1708	163	10	not	not	PART
concept-1708	163	11	to	to	PART
concept-1708	163	12	accurately	accurately	ADV
concept-1708	163	13	predict	predict	VERB
concept-1708	163	14	the	the	DET
concept-1708	163	15	exact	exact	ADJ
concept-1708	163	16	path	path	NOUN
concept-1708	163	17	the	the	DET
concept-1708	163	18	metastasis	metastasis	NOUN
concept-1708	163	19	will	will	AUX
concept-1708	163	20	take	take	VERB
concept-1708	163	21	,	,	PUNCT
concept-1708	163	22	but	but	CCONJ
concept-1708	163	23	to	to	PART
concept-1708	163	24	be	be	AUX
concept-1708	163	25	able	able	ADJ
concept-1708	163	26	to	to	PART
concept-1708	163	27	anticipate	anticipate	VERB
concept-1708	163	28	whether	whether	SCONJ
concept-1708	163	29	metastasis	metastasis	PRON
concept-1708	163	30	is	be	AUX
concept-1708	163	31	likely	likely	ADJ
concept-1708	163	32	or	or	CCONJ
concept-1708	163	33	not	not	PART
concept-1708	163	34	.	.	PUNCT
concept-1708	164	1	once	once	ADV
concept-1708	164	2	this	this	PRON
concept-1708	164	3	is	be	AUX
concept-1708	164	4	known	know	VERB
concept-1708	164	5	,	,	PUNCT
concept-1708	164	6	the	the	DET
concept-1708	164	7	physician	physician	NOUN
concept-1708	164	8	can	can	AUX
concept-1708	164	9	determine	determine	VERB
concept-1708	164	10	whether	whether	SCONJ
concept-1708	164	11	a	a	DET
concept-1708	164	12	general	general	ADJ
concept-1708	164	13	cancer	cancer	NOUN
concept-1708	164	14	treatment	treatment	NOUN
concept-1708	164	15	like	like	ADP
concept-1708	164	16	chemotherapy	chemotherapy	NOUN
concept-1708	164	17	is	be	AUX
concept-1708	164	18	necessary	necessary	ADJ
concept-1708	164	19	or	or	CCONJ
concept-1708	164	20	if	if	SCONJ
concept-1708	164	21	removing	remove	VERB
concept-1708	164	22	the	the	DET
concept-1708	164	23	primary	primary	ADJ
concept-1708	164	24	cancer	cancer	NOUN
concept-1708	164	25	with	with	ADP
concept-1708	164	26	radiation	radiation	NOUN
concept-1708	164	27	or	or	CCONJ
concept-1708	164	28	resection	resection	NOUN
concept-1708	164	29	would	would	AUX
concept-1708	164	30	be	be	AUX
concept-1708	164	31	enough	enough	ADJ
concept-1708	164	32	to	to	PART
concept-1708	164	33	rid	rid	VERB
concept-1708	164	34	the	the	DET
concept-1708	164	35	body	body	NOUN
concept-1708	164	36	of	of	ADP
concept-1708	164	37	dangerous	dangerous	ADJ
concept-1708	164	38	cancer	cancer	NOUN
concept-1708	164	39	cells	cell	NOUN
concept-1708	164	40	.	.	PUNCT
concept-1708	165	1	while	while	SCONJ
concept-1708	165	2	the	the	DET
concept-1708	165	3	studies	study	NOUN
concept-1708	165	4	that	that	PRON
concept-1708	165	5	were	be	AUX
concept-1708	165	6	discussed	discuss	VERB
concept-1708	165	7	have	have	VERB
concept-1708	165	8	various	various	ADJ
concept-1708	165	9	limitations	limitation	NOUN
concept-1708	165	10	,	,	PUNCT
concept-1708	165	11	there	there	PRON
concept-1708	165	12	are	be	VERB
concept-1708	165	13	results	result	NOUN
concept-1708	165	14	in	in	ADP
concept-1708	165	15	each	each	PRON
concept-1708	165	16	that	that	PRON
concept-1708	165	17	can	can	AUX
concept-1708	165	18	either	either	CCONJ
concept-1708	165	19	be	be	AUX
concept-1708	165	20	used	use	VERB
concept-1708	165	21	or	or	CCONJ
concept-1708	165	22	built	build	VERB
concept-1708	165	23	upon	upon	SCONJ
concept-1708	165	24	to	to	PART
concept-1708	165	25	become	become	VERB
concept-1708	165	26	beneficial	beneficial	ADJ
concept-1708	165	27	instruments	instrument	NOUN
concept-1708	165	28	in	in	ADP
concept-1708	165	29	the	the	DET
concept-1708	165	30	prognosis	prognosis	NOUN
concept-1708	165	31	of	of	ADP
concept-1708	165	32	cancer	cancer	NOUN
concept-1708	165	33	and	and	CCONJ
concept-1708	165	34	increasing	increase	VERB
concept-1708	165	35	a	a	DET
concept-1708	165	36	patient	patient	NOUN
concept-1708	165	37	’s	’s	PART
concept-1708	165	38	likelihood	likelihood	NOUN
concept-1708	165	39	of	of	ADP
concept-1708	165	40	remission	remission	NOUN
concept-1708	165	41	.	.	PUNCT
concept-1708	166	1	bibliography	bibliography	NOUN
concept-1708	166	2	metastatic	metastatic	ADJ
concept-1708	166	3	cancer	cancer	NOUN
concept-1708	166	4	fact	fact	NOUN
concept-1708	166	5	sheet	sheet	NOUN
concept-1708	166	6	.	.	PUNCT
concept-1708	167	1	national	national	PROPN
concept-1708	167	2	cancer	cancer	PROPN
concept-1708	167	3	institute	institute	PROPN
concept-1708	167	4	2013	2013	NUM
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concept-1708	167	6	w.y	w.y	PROPN
concept-1708	167	7	.	.	PROPN
concept-1708	167	8	tan	tan	PROPN
concept-1708	167	9	,	,	PUNCT
concept-1708	167	10	a	a	DET
concept-1708	167	11	stochastic	stochastic	ADJ
concept-1708	167	12	model	model	NOUN
concept-1708	167	13	for	for	ADP
concept-1708	167	14	the	the	DET
concept-1708	167	15	formation	formation	NOUN
concept-1708	167	16	of	of	ADP
concept-1708	167	17	metastatic	metastatic	ADJ
concept-1708	167	18	foci	focus	NOUN
concept-1708	167	19	at	at	ADP
concept-1708	167	20	distant	distant	ADJ
concept-1708	167	21	sites	site	NOUN
concept-1708	167	22	,	,	PUNCT
concept-1708	167	23	mathematical	mathematical	ADJ
concept-1708	167	24	and	and	CCONJ
concept-1708	167	25	computer	computer	NOUN
concept-1708	167	26	modeling	modeling	NOUN
concept-1708	167	27	,	,	PUNCT
concept-1708	167	28	volume	volume	NOUN
concept-1708	167	29	12	12	NUM
concept-1708	167	30	,	,	PUNCT
concept-1708	167	31	issue	issue	NOUN
concept-1708	167	32	9	9	NUM
concept-1708	167	33	,	,	PUNCT
concept-1708	167	34	1989	1989	NUM
concept-1708	167	35	,	,	PUNCT
concept-1708	167	36	pages	page	NOUN
concept-1708	167	37	1093	1093	NUM
concept-1708	167	38	-	-	SYM
concept-1708	167	39	1102	1102	NUM
concept-1708	167	40	,	,	PUNCT
concept-1708	167	41	issn	issn	PROPN
concept-1708	167	42	0895	0895	NUM
concept-1708	167	43	-	-	SYM
concept-1708	167	44	7177	7177	NUM
concept-1708	167	45	,	,	PUNCT
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concept-1708	167	47	.	.	PUNCT
concept-1708	168	1	(	(	PUNCT
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concept-1708	168	3	)	)	PUNCT
concept-1708	168	4	scott	scott	PROPN
concept-1708	168	5	,	,	PUNCT
concept-1708	168	6	j.	j.	PROPN
concept-1708	168	7	,	,	PUNCT
concept-1708	168	8	gerlee	gerlee	PROPN
concept-1708	168	9	,	,	PUNCT
concept-1708	168	10	p.	p.	PROPN
concept-1708	168	11	,	,	PUNCT
concept-1708	168	12	basanta	basanta	PROPN
concept-1708	168	13	d.	d.	PROPN
concept-1708	168	14	,	,	PUNCT
concept-1708	168	15	fletcher	fletcher	PROPN
concept-1708	168	16	,	,	PUNCT
concept-1708	168	17	a	a	PRON
concept-1708	168	18	,	,	PUNCT
concept-1708	168	19	maini	maini	PROPN
concept-1708	168	20	,	,	PUNCT
concept-1708	168	21	p.	p.	PROPN
concept-1708	168	22	,	,	PUNCT
concept-1708	168	23	anderson	anderson	PROPN
concept-1708	168	24	,	,	PUNCT
concept-1708	168	25	a.	a.	PROPN
concept-1708	168	26	mathematical	mathematical	PROPN
concept-1708	168	27	modeling	modeling	NOUN
concept-1708	168	28	of	of	ADP
concept-1708	168	29	the	the	DET
concept-1708	168	30	metastatic	metastatic	ADJ
concept-1708	168	31	process	process	NOUN
concept-1708	168	32	.	.	PUNCT
concept-1708	169	1	eprint	eprint	NOUN
concept-1708	169	2	arxiv:1305.4622	arxiv:1305.4622	NUM
concept-1708	169	3	,	,	PUNCT
concept-1708	169	4	2013	2013	NUM
concept-1708	169	5	.	.	PUNCT
concept-1708	170	1	http://adsabs.harvard.edu/cgibin/bib_query?arxiv:1305.4622	http://adsabs.harvard.edu/cgibin/bib_query?arxiv:1305.4622	NOUN
concept-1708	170	2	.	.	PUNCT
concept-1708	171	1	bozic	bozic	PROPN
concept-1708	171	2	,	,	PUNCT
concept-1708	171	3	i.	i.	PROPN
concept-1708	171	4	mathematical	mathematical	PROPN
concept-1708	171	5	models	model	NOUN
concept-1708	171	6	of	of	ADP
concept-1708	171	7	cancer	cancer	NOUN
concept-1708	171	8	.	.	PUNCT
concept-1708	172	1	(	(	PUNCT
concept-1708	172	2	order	order	VERB
concept-1708	172	3	no	no	INTJ
concept-1708	172	4	.	.	NOUN
concept-1708	172	5	3513903	3513903	NUM
concept-1708	172	6	,	,	PUNCT
concept-1708	172	7	harvard	harvard	PROPN
concept-1708	172	8	university	university	PROPN
concept-1708	172	9	)	)	PUNCT
concept-1708	172	10	.	.	PUNCT
concept-1708	173	1	proquest	proquest	PROPN
concept-1708	173	2	dissertations	dissertation	NOUN
concept-1708	173	3	and	and	CCONJ
concept-1708	173	4	theses	thesis	NOUN
concept-1708	173	5	,	,	PUNCT
concept-1708	173	6	134	134	NUM
concept-1708	173	7	,	,	PUNCT
concept-1708	173	8	2012	2012	NUM
concept-1708	173	9	.	.	PUNCT
concept-1708	174	1	retrieved	retrieve	VERB
concept-1708	174	2	from	from	ADP
concept-1708	174	3	http://ezproxy.villanova.edu/login?url=http://search.proquest.com/doc	http://ezproxy.villanova.edu/login?url=http://search.proquest.com/doc	PROPN
concept-1708	174	4	view/1027777143?accountid=14853	view/1027777143?accountid=14853	NOUN
concept-1708	174	5	.	.	PUNCT
concept-1708	175	1	(	(	PUNCT
concept-1708	175	2	1027777143	1027777143	NUM
concept-1708	175	3	)	)	PUNCT
concept-1708	175	4	.	.	PUNCT
concept-1708	176	1	divoli	divoli	PROPN
concept-1708	176	2	,	,	PUNCT
concept-1708	176	3	a.	a.	NOUN
concept-1708	176	4	,	,	PUNCT
concept-1708	176	5	mendonça	mendonça	PROPN
concept-1708	176	6	,	,	PUNCT
concept-1708	176	7	e.a	e.a	PROPN
concept-1708	176	8	.	.	PROPN
concept-1708	176	9	,	,	PUNCT
concept-1708	176	10	evans	evans	PROPN
concept-1708	176	11	,	,	PUNCT
concept-1708	176	12	j.a	j.a	PROPN
concept-1708	176	13	.	.	PROPN
concept-1708	176	14	,	,	PUNCT
concept-1708	176	15	rzhetsky	rzhetsky	ADJ
concept-1708	176	16	,	,	PUNCT
concept-1708	176	17	a.	a.	NOUN
concept-1708	176	18	conflicting	conflict	VERB
concept-1708	176	19	biomedical	biomedical	ADJ
concept-1708	176	20	assumptions	assumption	NOUN
concept-1708	176	21	for	for	ADP
concept-1708	176	22	mathematical	mathematical	ADJ
concept-1708	176	23	modeling	modeling	NOUN
concept-1708	176	24	:	:	PUNCT
concept-1708	176	25	the	the	DET
concept-1708	176	26	case	case	NOUN
concept-1708	176	27	of	of	ADP
concept-1708	176	28	cancer	cancer	NOUN
concept-1708	176	29	metastasis	metastasis	NOUN
concept-1708	176	30	.	.	PUNCT
concept-1708	177	1	plos	plos	PROPN
concept-1708	177	2	comput	comput	PROPN
concept-1708	177	3	biol	biol	PROPN
concept-1708	177	4	7(10	7(10	NUM
concept-1708	177	5	):	):	PUNCT
concept-1708	177	6	e1002132	e1002132	PROPN
concept-1708	177	7	.	.	PUNCT
concept-1708	177	8	doi:10.1371	doi:10.1371	PROPN
concept-1708	177	9	/	/	PUNCT
concept-1708	178	1	journal.pcbi.1002132	journal.pcbi.1002132	PROPN
concept-1708	178	2	(	(	PUNCT
concept-1708	178	3	2011	2011	NUM
concept-1708	178	4	)	)	PUNCT
concept-1708	178	5	.	.	PUNCT
concept-1708	178	6	  	  	SPACE
concept-1708	179	1	laird	laird	PROPN
concept-1708	179	2	,	,	PUNCT
concept-1708	179	3	a.k	a.k	PROPN
concept-1708	179	4	.	.	PROPN
concept-1708	179	5	dynamics	dynamic	NOUN
concept-1708	179	6	of	of	ADP
concept-1708	179	7	tumor	tumor	NOUN
concept-1708	179	8	growth	growth	NOUN
concept-1708	179	9	.	.	PUNCT
concept-1708	180	1	british	british	ADJ
concept-1708	180	2	journal	journal	PROPN
concept-1708	180	3	of	of	ADP
concept-1708	180	4	cancer	cancer	NOUN
concept-1708	180	5	(	(	PUNCT
concept-1708	180	6	1964	1964	NUM
concept-1708	180	7	)	)	PUNCT
concept-1708	180	8	18	18	NUM
concept-1708	180	9	,	,	PUNCT
concept-1708	180	10	490–502	490–502	NUM
concept-1708	180	11	.	.	PUNCT
concept-1708	181	1	doi:10.1038	doi:10.1038	NOUN
concept-1708	181	2	/	/	SYM
concept-1708	181	3	bjc.1964.55	bjc.1964.55	NUM
concept-1708	181	4	www.bjcancer.com	www.bjcancer.com	NOUN
concept-1708	181	5	.	.	PUNCT
concept-1708	182	1	ao	ao	PROPN
concept-1708	182	2	,	,	PUNCT
concept-1708	182	3	p.	p.	NOUN
concept-1708	182	4	,	,	PUNCT
concept-1708	182	5	galas	gala	NOUN
concept-1708	182	6	,	,	PUNCT
concept-1708	182	7	d.	d.	PROPN
concept-1708	182	8	,	,	PUNCT
concept-1708	182	9	hood	hood	PROPN
concept-1708	182	10	,	,	PUNCT
concept-1708	182	11	l.	l.	PROPN
concept-1708	182	12	,	,	PUNCT
concept-1708	182	13	yin	yin	PROPN
concept-1708	182	14	,	,	PUNCT
concept-1708	182	15	l.	l.	PROPN
concept-1708	182	16	,	,	PUNCT
concept-1708	182	17	&	&	CCONJ
concept-1708	182	18	zhu	zhu	PROPN
concept-1708	182	19	,	,	PUNCT
concept-1708	182	20	x.m	x.m	PROPN
concept-1708	182	21	.	.	PROPN
concept-1708	183	1	towards	towards	ADP
concept-1708	183	2	predictive	predictive	ADJ
concept-1708	183	3	stochastic	stochastic	ADJ
concept-1708	183	4	dynamical	dynamical	ADJ
concept-1708	183	5	modeling	modeling	NOUN
concept-1708	183	6	of	of	ADP
concept-1708	183	7	cancer	cancer	NOUN
concept-1708	183	8	genesis	genesis	NOUN
concept-1708	183	9	and	and	CCONJ
concept-1708	183	10	progression	progression	NOUN
concept-1708	183	11	.	.	PUNCT
concept-1708	184	1	interdisciplinary	interdisciplinary	ADJ
concept-1708	184	2	sciences	science	NOUN
concept-1708	184	3	,	,	PUNCT
concept-1708	184	4	computational	computational	ADJ
concept-1708	184	5	life	life	NOUN
concept-1708	184	6	sciences	science	NOUN
concept-1708	184	7	,	,	PUNCT
concept-1708	184	8	2(2	2(2	NUM
concept-1708	184	9	)	)	PUNCT
concept-1708	184	10	,	,	PUNCT
concept-1708	184	11	140	140	NUM
concept-1708	184	12	-	-	SYM
concept-1708	184	13	4	4	NUM
concept-1708	184	14	.	.	PUNCT
concept-1708	184	15	(	(	PUNCT
concept-1708	184	16	2010	2010	NUM
concept-1708	184	17	)	)	PUNCT
concept-1708	184	18	.	.	PUNCT
concept-1708	185	1	doi	doi	NOUN
concept-1708	185	2	:	:	PUNCT
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concept-1708	185	4	/	/	SYM
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concept-1708	185	6	-	-	PUNCT
concept-1708	185	7	010	010	NUM
concept-1708	185	8	-	-	PUNCT
concept-1708	185	9	0072	0072	NUM
concept-1708	185	10	-	-	SYM
concept-1708	185	11	3	3	NUM
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concept-1708	185	13	,	,	PUNCT
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concept-1708	185	16	,	,	PUNCT
concept-1708	185	17	mason	mason	PROPN
concept-1708	185	18	,	,	PUNCT
concept-1708	185	19	j.	j.	PROPN
concept-1708	185	20	,	,	PUNCT
concept-1708	185	21	bethel	bethel	PROPN
concept-1708	185	22	,	,	PUNCT
concept-1708	185	23	k.	k.	PROPN
concept-1708	185	24	,	,	PUNCT
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concept-1708	185	26	,	,	PUNCT
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concept-1708	185	28	.	.	PROPN
concept-1708	185	29	,	,	PUNCT
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concept-1708	185	31	,	,	PUNCT
concept-1708	185	32	j.	j.	PROPN
concept-1708	185	33	,	,	PUNCT
concept-1708	185	34	and	and	CCONJ
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concept-1708	185	36	,	,	PUNCT
concept-1708	185	37	p.	p.	NOUN
concept-1708	185	38	a	a	DET
concept-1708	185	39	stochastic	stochastic	ADJ
concept-1708	185	40	markov	markov	NOUN
concept-1708	185	41	chain	chain	NOUN
concept-1708	185	42	model	model	NOUN
concept-1708	185	43	to	to	PART
concept-1708	185	44	describe	describe	VERB
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concept-1708	185	46	cancer	cancer	NOUN
concept-1708	185	47	growth	growth	NOUN
concept-1708	185	48	and	and	CCONJ
concept-1708	185	49	metastasis	metastasis	NOUN
concept-1708	185	50	.	.	PUNCT
concept-1708	186	1	plos	plos	PROPN
concept-1708	186	2	one	one	NUM
concept-1708	186	3	,	,	PUNCT
concept-1708	186	4	7(4):e34637	7(4):e34637	NUM
concept-1708	186	5	(	(	PUNCT
concept-1708	186	6	2013	2013	NUM
concept-1708	186	7	)	)	PUNCT
concept-1708	186	8	.	.	PUNCT
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concept-1708	187	2	-	-	PUNCT
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concept-1708	187	4	,	,	PUNCT
concept-1708	187	5	i.	i.	PROPN
concept-1708	187	6	,	,	PUNCT
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concept-1708	187	8	,	,	PUNCT
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concept-1708	187	11	,	,	PUNCT
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concept-1708	187	13	,	,	PUNCT
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concept-1708	187	15	.	.	PUNCT
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concept-1708	187	24	.	.	PUNCT
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concept-1708	188	2	.	.	PUNCT
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concept-1708	189	2	.	.	PUNCT
concept-1708	190	1	model	model	PROPN
concept-1708	190	2	.	.	PUNCT
concept-1708	191	1	(	(	PUNCT
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concept-1708	191	3	)	)	PUNCT
concept-1708	191	4	.	.	PUNCT
concept-1708	192	1	in	in	ADP
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concept-1708	192	3	.	.	PUNCT
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concept-1708	193	2	,	,	PUNCT
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concept-1708	193	4	,	,	PUNCT
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concept-1708	193	6	,	,	PUNCT
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concept-1708	193	8	,	,	PUNCT
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concept-1708	193	10	,	,	PUNCT
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concept-1708	193	13	,	,	PUNCT
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concept-1708	193	17	.	.	PUNCT
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concept-1708	194	12	.	.	PUNCT
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concept-1708	195	5	(	(	PUNCT
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concept-1708	195	7	)	)	PUNCT
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concept-1708	195	9	-	-	SYM
concept-1708	195	10	179	179	NUM
concept-1708	195	11	.	.	PUNCT
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concept-1708	197	4	(	(	PUNCT
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concept-1708	197	6	)	)	PUNCT
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concept-1708	197	8	-	-	SYM
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concept-1708	197	10	.	.	PUNCT
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concept-1708	198	2	,	,	PUNCT
concept-1708	198	3	s.	s.	PROPN
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concept-1708	198	5	,	,	PUNCT
concept-1708	198	6	&	&	CCONJ
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concept-1708	198	8	,	,	PUNCT
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concept-1708	198	14	cavity	cavity	NOUN
concept-1708	198	15	fluid	fluid	NOUN
concept-1708	198	16	and	and	CCONJ
concept-1708	198	17	cerebrospinal	cerebrospinal	ADJ
concept-1708	198	18	fluid	fluid	NOUN
concept-1708	198	19	cytopathology	cytopathology	NOUN
concept-1708	198	20	11	11	NUM
concept-1708	198	21	(	(	PUNCT
concept-1708	198	22	2012	2012	NUM
concept-1708	198	23	)	)	PUNCT
concept-1708	198	24	77	77	NUM
concept-1708	198	25	-	-	SYM
concept-1708	198	26	131	131	NUM
concept-1708	198	27	.	.	PUNCT
concept-1708	199	1	doi:10.1007/978	doi:10.1007/978	NOUN
concept-1708	199	2	-	-	PUNCT
concept-1708	199	3	1	1	NUM
concept-1708	199	4	-	-	PUNCT
concept-1708	199	5	4614	4614	NUM
concept-1708	199	6	-	-	PUNCT
concept-1708	199	7	1776	1776	NUM
concept-1708	199	8	-	-	PUNCT
concept-1708	199	9	7_5	7_5	NUM
concept-1708	199	10	weisstein	weisstein	NOUN
concept-1708	199	11	,	,	PUNCT
concept-1708	199	12	eric	eric	PROPN
concept-1708	199	13	w.	w.	PROPN
concept-1708	199	14	“	"	PUNCT
concept-1708	199	15	monte	monte	PROPN
concept-1708	199	16	carlo	carlo	PROPN
concept-1708	199	17	method	method	NOUN
concept-1708	199	18	.	.	PUNCT
concept-1708	199	19	”	"	PUNCT
concept-1708	200	1	from	from	ADP
concept-1708	200	2	mathworld	mathworld	NOUN
concept-1708	200	3	--	--	PUNCT
concept-1708	200	4	a	a	DET
concept-1708	200	5	wolfram	wolfram	PROPN
concept-1708	200	6	web	web	NOUN
concept-1708	200	7	resource	resource	NOUN
concept-1708	200	8	.	.	PUNCT
concept-1708	200	9	http://mathworld.wolfram.com/montecarlomethod.html	http://mathworld.wolfram.com/montecarlomethod.html	NOUN
concept-1708	200	10	liotta	liotta	PROPN
concept-1708	200	11	,	,	PUNCT
concept-1708	200	12	l.a	l.a	PROPN
concept-1708	200	13	.	.	PROPN
concept-1708	200	14	,	,	PUNCT
concept-1708	200	15	saidel	saidel	PROPN
concept-1708	200	16	,	,	PUNCT
concept-1708	200	17	g.m	g.m	PROPN
concept-1708	200	18	.	.	PROPN
concept-1708	200	19	,	,	PUNCT
concept-1708	200	20	kleinerman	kleinerman	PROPN
concept-1708	200	21	,	,	PUNCT
concept-1708	200	22	j.	j.	PROPN
concept-1708	200	23	stochastic	stochastic	ADJ
concept-1708	200	24	model	model	NOUN
concept-1708	200	25	of	of	ADP
concept-1708	200	26	metastases	metastasis	NOUN
concept-1708	200	27	formation	formation	NOUN
concept-1708	200	28	.	.	PUNCT
concept-1708	201	1	biometrics	biometric	NOUN
concept-1708	201	2	32	32	NUM
concept-1708	201	3	(	(	PUNCT
concept-1708	201	4	1976	1976	NUM
concept-1708	201	5	)	)	PUNCT
concept-1708	201	6	535	535	NUM
concept-1708	201	7	-	-	SYM
concept-1708	201	8	550	550	NUM
concept-1708	201	9	biology-online.org	biology-online.org	NOUN
concept-1708	201	10	.	.	PUNCT
concept-1708	202	1	online	online	PROPN
concept-1708	202	2	dictionary	dictionary	PROPN
concept-1708	202	3	of	of	ADP
concept-1708	202	4	medical	medical	ADJ
concept-1708	202	5	and	and	CCONJ
concept-1708	202	6	scientific	scientific	ADJ
concept-1708	202	7	terms	term	NOUN
concept-1708	202	8	.	.	PUNCT
concept-1708	202	9	      	      	SPACE