item: #1 of 177 id: cord-000072-2ygb80sc author: van Meurs, Matijs title: Bench-to-bedside review: Angiopoietin signalling in critical illness – a future target? date: 2009-03-09 words: 6891 flesch: 32 summary: ABIN-2 protects endothelial cells from death and has a role in the antiapoptotic effect of angiopoietin-1 Roles of reactive oxygen species in angiopoietin-1/tie-2 receptor signaling Differential function of Tie2 at cell-cell contacts and cell-substratum contacts regulated by angiopoietin-1 Angiopoietin-2 displays VEGFdependent modulation of capillary structure and endothelial cell survival in vivo Differential response of lymphatic, venous and arterial endothelial cells to angiopoietin-1 and angiopoietin-2 Biological action of angiopoietin-2 in a fibrin matrix model of angiogenesis is associated with activation of Tie2 Angiogenesis and inflammation face off Innate immunity and angiogenesis Transcriptional regulators of angiogenesis Extracellular matrix mediates a molecular balance between vascular morphogenesis and regression The Tie-2 ligand angiopoietin-2 destabilizes quiescent endothelium through an internal autocrine loop mechanism Angiopoietin-1 and vascular endothelial growth factor induce expression of inflammatory cytokines before angiogenesis Recombinant angiopoietin-1 restores higher-order architecture of growing blood vessels in mice in the absence of mural cells Contextual role for angiopoietins and TGFbeta1 in blood vessel stabilization Angiopoietin-1 is an apoptosis survival factor for endothelial cells Direct actions of angiopoietin-1 on human endothelium: evidence for network stabilization, cell survival, and interaction with other angiogenic growth factors Angiopoietin-1 inhibits endothelial cell apoptosis via the Akt/survivin pathway Cyclic strain regulates the Notch/CBF-1 signaling pathway in endothelial cells: role in angiogenic activity Expression of Tie-2 by human monocytes and their responses to angiopoietin-2 Transcriptional and post-translation regulation of the Tie1 receptor by fluid shear stress changes in vascular endothelial cells Chemotactic properties of angiopoietin-1 and -2, ligands for the endothelial-specific receptor tyrosine kinase Tie2 Obligatory participation of macrophages in an angiopoietin 2-mediated cell death switch Angiopoietin-2 causes inflammation in vivo by promoting vascular leakage Expressional regulation of the angiopoietin-1 and -2 and the endothelial-specific receptor tyrosine kinase Tie2 in adrenal atrophy: a study of adrenocorticotropin-induced repair Angiopoietins: a link between angiogenesis and inflammation Angiopoietin-1 decreases plasma leakage by reducing number and size of endothelial gaps in venules Angiopoietin-1 protects the adult vasculature against plasma leakage Angiopoietin-1 negatively regulates expression and activity of tissue factor in endothelial cells Angiopoietin-1 is an antipermeability and anti-inflammatory agent in vitro and targets cell junctions Angiopoietin-1 reduces VEGF-stimulated leukocyte adhesion to endothelial cells by reducing ICAM-1, VCAM-1, and E-selectin expression Angiopoietin-1 inhibits endothelial permeability, neutrophil adherence and IL-8 production Angiopoietin 1 and vascular endothelial growth factor modulate human glomerular endothelial cell barrier properties Angiopoietin-2 sensitizes endothelial cells to TNF-alpha and has a crucial role in the induction of inflammation Hypoxia and vascular endothelial growth factor acutely up-regulate angiopoietin-1 and Tie2 mRNA in bovine retinal pericytes Hypoxic regulation of angiopoietin-2 expression in endothelial cells Regulation of angiopoietin expression by bacterial lipopolysaccharide Angiogenic growth factors in the pathophysiology of a murine model of acute lung injury Prevention of LPS-induced acute lung injury in mice by mesenchymal stem cells overexpressing angiopoietin 1 Sequential induction of angiogenic growth factors by TNFalpha in choroidal endothelial cells Tumor necrosis factoralpha upregulates angiopoietin-2 in human umbilical vein endothelial cells Regulation of tie2 expression by angiopoietin-potential feedback system Osteoprotegerin upregulates endothelial cell adhesion molecule response to tumor necrosis factor-alpha associated with induction of angiopoietin-2 Angiopoietin-mediated endothelial P-selectin translocation: cell signaling mechanisms Ang-2 and PDGF-BB cooperatively stimulate The role of adherens junctions and VE-cadherin in the control of vascular permeability VEGF receptor 2 and the adherens junction as a mechanical transducer in vascular endothelial cells Opposing effect of angiopoietin-1 on VEGF-mediated disruption of endothelial cell-cell interactions requires activation of PKC beta Angiopoietin-1 prevents VEGFinduced endothelial permeability by sequestering Src through mDia Stable interaction between alpha5beta1 integrin and Tie2 tyrosine kinase receptor regulates endothelial cell response to Ang-1 Elevated serum angiopoietin-2 correlates with degree of arteriosclerosis in CKD V patients Emerging roles of the angiopoietin-Tie and the ephrin-Eph systems as regulators of cell trafficking Endothelial immunogenicity: a matter of matrix microarchitecture Vascular bed origin dictates flow pattern regulation of endothelial adhesion molecule expression Angiogenesis: potentials for pharmacologic intervention in the treatment of cancer, cardiovascular diseases, and chronic inflammation Angiogenesis treatment, new concepts on the horizon Inhibition of Tie-2 signaling induces endothelial cell apoptosis, decreases Akt signaling, and induces endothelial cell expression of the endogenous anti-angiogenic molecule, thrombospondin-1 Kerbel RS: Tumor angiogenesis Coadministration of angiopoietin-1 and vascular endothelial growth factor enhances collateral vascularization Combined angiopoietin-1 and vascular endothelial growth factor gene transfer restores cavernous angiogenesis and erectile function in a rat model of hypercholesterolemia Inhibitors of growth factor receptors, signaling pathways and angiogenesis as therapeutic molecular agents Biomedical significance of endothelial cell specific growth factor, angiopoietin Angiopoietin-2: modulator of vascular permeability in acute lung injury COMP-Ang1: a designed angiopoietin-1 variant with nonleaky angiogenic activity Renoprotective effect of COMP-angiopoietin-1 in db/db mice with type 2 diabetes Critical role of angiopoietins/Tie-2 in hyperglycemic exacerbation of myocardial infarction and impaired angiogenesis Vascular endothelial growth factor gene therapy increases survival, promotes lung angiogenesis, and prevents alveolar damage in hyperoxia-induced lung injury: evidence that angiogenesis participates in alveolarization Protective role of angiopoietin-1 in endotoxic shock Angiopoietin-1 prevents hypertension and target organ damage through its interaction with endothelial Tie2 receptor Angiopoietin 2 concentrations in infants developing bronchopulmonary dysplasia: attenuation by dexamethasone Inhibition of in vivo tumor angiogenesis and growth via systemic delivery of an angiopoietin 2-specific RNA aptamer Therapeutic application of RNAi: is mRNA targeting finally ready for prime time? Angiopoietin/Tie2 pathway influences smooth muscle hyperplasia in idiopathic pulmonary hypertension Relationship between vascular endothelial growth factor and angiopoietin-2 in asthmatics before and after inhaled beclomethasone therapy Normalization of the serum angiopoietin-1 to angiopoietin-2 ratio reflects response in refractory/resistant multiple myeloma patients treated with bortezomib Serum angiopoietin-2 as a clinical marker for lung cancer Angiopoietin-2 predicts disease-free survival after allogeneic stem cell transplantation in patients with high-risk myeloid malignancies The full cycle Angiopoietin 2 is a potential mediator of high-dose interleukin 2-induced vascular leak Angiopoietin-2 serum levels are elevated in patients with liver cirrhosis and hepatocellular carcinoma keywords: ang-1; angiogenesis; angiopoietin-1; cell; ecs; endothelial; expression; factor; inflammation; patients; signalling; system; tie2; vascular cache: cord-000072-2ygb80sc.txt plain text: cord-000072-2ygb80sc.txt item: #2 of 177 id: cord-000086-bnkbwh3w author: Kneyber, Martin CJ title: Heliox reduces respiratory system resistance in respiratory syncytial virus induced respiratory failure date: 2009-05-15 words: 4833 flesch: 42 summary: Respiratory syncytial virus and parainfluenza virus Bronchiolitis-associated hospitalizations among US children Recent trends in severe respiratory syncytial virus (RSV) among US infants Advances in respiratory syncytial virus vaccine development The pathogenesis of respiratory syncytial virus disease in childhood Pathological changes in virus infections of the lower respiratory tract in children Mechanical ventilatory support in infants with respiratory syncytial virus infection Ribavirin in ventilated respiratory syncytial virus bronchiolitis. • MV with heliox decreases respiratory system resistance in RSV LRTD. keywords: heliox; infants; lung; patients; relative; rsv; ventilation; volume cache: cord-000086-bnkbwh3w.txt plain text: cord-000086-bnkbwh3w.txt item: #3 of 177 id: cord-000161-hxjxczyr author: Rello, Jordi title: Clinical review: Primary influenza viral pneumonia date: 2009-12-21 words: 3655 flesch: 29 summary: The real-time reverse transcriptase-polymerase chain reaction (rRT-PCR) Swine Flu Panel for detection of pandemic H1N1 influenza, developed by the Centers for Disease Control and Prevention (Atlanta, GA, USA) and distributed to many laboratories in US and worldwide, is a reliable and timely method of diagnosing the pandemic strain [32, 33] . [35] and unacceptably insensitive for the detection of pandemic H1N1 influenza keywords: acute; h1n1; infection; influenza; pandemic; patients; pneumonia; strain; virus cache: cord-000161-hxjxczyr.txt plain text: cord-000161-hxjxczyr.txt item: #4 of 177 id: cord-000217-chd9ezba author: Anas, Adam title: Role of CD14 in lung inflammation and infection date: 2010-03-09 words: 5603 flesch: 38 summary: However, when a high dose of LPS was administered to the lungs of mice, acute lung infl ammation was absent in mice lacking functional TLR4, but only partially reduced in CD14 defi cient mice [24] . Interestingly, despite impaired bacterial clearance in CD14-defi cient and TLR4-defi cient mice, the infl ammatory response in the lung was strongly reduced in TLR4 defi cient mice, but elevated in CD14 defi cient mice. keywords: binding; cd14; cient; defi; infl; lps; lung; mice; protein; response; tlr4 cache: cord-000217-chd9ezba.txt plain text: cord-000217-chd9ezba.txt item: #5 of 177 id: cord-000492-ec5qzurk author: Devaney, James title: Clinical Review: Gene-based therapies for ALI/ARDS: where are we now? date: 2011-06-20 words: 6021 flesch: 34 summary: Antibodies that bind antigens selectively expressed on the pulmonary endothelial surface can be complexed to gene vectors to facilitate selective targeting following intravenous administration + ,K + -ATPase rescues endotoxin-induced lung injury Interleukin-10 gene transfer: prevention of multiple organ injury in a murine cecal ligation and puncture model of sepsis Nonviral gene delivery with indoleamine 2,3-dioxygenase targeting pulmonary endothelium protects against ischemia-reperfusion injury Silencing of Fas, but not caspase-8, in lung epithelial cells ameliorates pulmonary apoptosis, infl ammation, and neutrophil infl ux after hemorrhagic shock and sepsis Caveolin-1 siRNA increases the pulmonary microvascular and alveolar epithelial permeability in rats Interleukin-10 delivery via mesenchymal stem cells: a novel gene therapy approach to prevent lung ischemia-reperfusion injury Bone marrow stem cells expressing keratinocyte growth factor via an inducible lentivirus protects against bleomycin-induced pulmonary fi brosis Cell-based gene transfer of vascular endothelial growth factor attenuates monocrotaline-induced pulmonary hypertension Microvascular regeneration in established pulmonary hypertension by angiogenic gene transfer Tetracycline-inducible transgene expression mediated by a single AAV vector Effi cient transfection of non-proliferating human airway epithelial cells with a synthetic vector system Tailoring the AAV vector capsid for gene therapy Artifi cial evolution with adeno-associated viral libraries Analysis and optimization of the cationic lipid component of a lipid/ peptide vector formulation for enhanced transfection in vitro and in vivo Stabilized integrin-targeting ternary LPD (lipopolyplex) vectors for gene delivery designed to disassemble within the target cell CpG-free plasmids confer reduced infl ammation and sustained pulmonary gene expression Toll-like receptor expression reveals CpG DNA as a unique microbial stimulus for plasmacytoid dendritic cells which synergizes with CD40 ligand to induce high amounts of IL-12 Targeting type II and Clara cells for adenovirus-mediated gene transfer using the surfactant protein B promoter Development of lentiviral vectors with regulated respiratory epithelial expression in vivo Expression of CFTR from a ciliated cell-specifi c promoter is ineff ective at correcting nasal potential diff erence in CF mice A human epithelium-specifi c vector optimized in rat pneumocytes for lung gene therapy Tight control of gene expression in mammalian cells by tetracycline-responsive promoters Use of a new generation reverse tetracycline transactivator system for quantitative control of conditional gene expression in the murine lung Construction of an rtTA2(s)-m2/ tts(kid)-based transcription regulatory switch that displays no basal activity, good inducibility, and high responsiveness to doxycycline in mice and non-human primates Adenoviral vector transfection into the pulmonary epithelium after cecal ligation and puncture in rats Ubiquitination of both adeno-associated virus type 2 and 5 capsid proteins aff ects the transduction effi ciency of recombinant vectors GP130-STAT3 regulates epithelial cell migration and is required for repair of the bronchiolar epithelium Spatial and temporal expression of surfactant proteins in hyperoxia-induced neonatal rat lung injury Intrapulmonary TNF gene therapy reverses sepsis-induced suppression of lung antibacterial host defense Clinical Review: Gene-based therapies for ALI/ARDS: where are we now? keywords: ali; approaches; ards; cell; expression; gene; injury; lung; pulmonary; specifi; therapy; transfer; vectors cache: cord-000492-ec5qzurk.txt plain text: cord-000492-ec5qzurk.txt item: #6 of 177 id: cord-000498-absjerdt author: Hagau, Natalia title: Clinical aspects and cytokine response in severe H1N1 influenza A virus infection date: 2010-11-09 words: 5214 flesch: 47 summary: During the ICU hospitalization, critical patients with influenza virus infection (ARDS) received corticosteroid therapy (hydrocortisone or methylprednisolone). Th cells costimulated by intercellular adhesion molecule-1.I. IL-12 alters caspase processing and inhibits enzyme function Cytokine-mediated protection of human dendritic cells from prostate cancer-induced apoptosis is regulated by the Bcl-2 family of proteins Positive regulatory role of IL-12 in macrophages and modulation by IFN-gamma Influenza A virus-induced apoptosis in bronchiolar epithelial (NCI-H292) cells limits pro-inflammatory cytokine release IL-15 promotes the survival of naïve and memory phenotype CD8 + T cells IL-15 regulates CD8 + T cell contraction during primary infection Interleukin-15 is critical in the pathogenesis of influenza a virus-induced acute lung injury IL-15 mimics T cell receptor crosslinking in the induction of cellular proliferation, gene expression, and cytotoxicity in CD8 + memory T cells Interleukin-17 and Type 17 helper T cells Th17 cells: effector T cells with inflammatory properties Innate immune control and regulation of influenza virus infections Plasma interleukin-8 concentrations are increased in obese subjects and related to fat mass and tumor necrosis factor-α system Chronic obstructive pulmonary disease: molecular and cellular mechanisms An immune basis for lung parenchymal destruction in chronic obstructive pulmonary disease and emphysema IL-9 regulates pathology during primary and memory responses to respiratory syncytial virus infection Prolonged methylprednisolone treatment suppresses systemic inflammation in patients with unresolving acute respiratory distress syndrome. keywords: admission; ards; disease; group; il-6; il-8; infection; influenza; levels; nva(h1n1)-ards; patients cache: cord-000498-absjerdt.txt plain text: cord-000498-absjerdt.txt item: #7 of 177 id: cord-000522-d498qj2b author: Vincent, Jean-Louis title: Reducing mortality in sepsis: new directions date: 2002-12-05 words: 8718 flesch: 43 summary: Interestingly, this decrease was apparent even before the five interventions discussed in the present article were published, reflecting improvements in the general supportive care of sepsis patients. Generalists have been taught to recognize the signs Sepsis patients often come 'second hand' from a and symptoms of AMI; initial treatment is usually specialist who may not be appropriately trained to provided by emergency physicians, who are trained diagnose, manage, and refer patients with sepsis to treat these patients Mortality prior to hospital discharge in patients receiving a tidal volume of 6 and 12 ml/kg ideal body weight. keywords: alfa; care; drotrecogin; group; icu; interventions; mortality; patients; protein; sepsis; shock; study; therapy; treatment; trial cache: cord-000522-d498qj2b.txt plain text: cord-000522-d498qj2b.txt item: #8 of 177 id: cord-000705-w52dc97h author: Ríos, Fernando G title: Lung Function and Organ Dysfunctions in 178 Patients Requiring Mechanical Ventilation During The 2009 Influenza A (H1N1) Pandemic date: 2011-08-17 words: 4860 flesch: 43 summary: This was a multicenter, inception cohort study that included patients aged > 15 years admitted to the ICU with a previous history of influenza-like illness, evolving to acute respiratory failure that required mechanical ventilation during the 2009 winter in the Southern Hemisphere. Positive end-expiratory pressure setting in adults with acute lung injury and acute respiratory distress syndrome: a randomized controlled trial Anzueto A: Tidal volume in mechanical ventilation: the importance of considering predicted body weight Pressure-and Volume-Limited Ventilation Strategy Group: Evaluation of a ventilation strategy to prevent barotrauma in patients at high risk for acute respiratory distress syndrome The Multicenter Trail Group on Tidal Volume reduction in ARDS: keywords: acute; day; h1n1; influenza; non; pandemic; patients; study; survivors; ventilation cache: cord-000705-w52dc97h.txt plain text: cord-000705-w52dc97h.txt item: #9 of 177 id: cord-000891-5r2in1gw author: Giannella, Maddalena title: Should lower respiratory tract secretions from intensive care patients be systematically screened for influenza virus during the influenza season? date: 2012-06-14 words: 4120 flesch: 39 summary: Multivariate analysis showed admission to the surgical ICU (odds ratio (OR), 37.1; 95% confidence interval (CI), 2.1 to 666.6; P = 0.01) and localized infiltrate on chest radiograph (OR, 27.8; 95% CI, 1.3 to 584.1; P = 0.03) to be independent risk factors for unsuspected influenza. A logistic binary model was used to analyze the independent risk factors for unsuspected influenza and 30-day mortality. keywords: admission; cases; diagnosis; hospital; icu; influenza; pandemic; patients; samples cache: cord-000891-5r2in1gw.txt plain text: cord-000891-5r2in1gw.txt item: #10 of 177 id: cord-000892-l9862er0 author: Richard, Jean-Christophe Marie title: Interest of a simple on-line screening registry for measuring ICU burden related to an influenza pandemic date: 2012-07-09 words: 3964 flesch: 47 summary: At the same time, we recorded data corresponding to the cohort of ICU patients through a large research network on mechanical ventilation (REVA-SRLF registry) An on-line screening registry allowed a daily report of ICU beds occupancy rate by flu infected patients (Flu-OR) admitted in French ICUs. keywords: flu; icu; icus; influenza; pandemic; patients; registry; study; university cache: cord-000892-l9862er0.txt plain text: cord-000892-l9862er0.txt item: #11 of 177 id: cord-001293-dfaxj3bv author: Cavaillon, Jean-Marc title: Is boosting the immune system in sepsis appropriate? date: 2014-03-24 words: 6247 flesch: 27 summary: The clinical observations used to argue that immunosuppression occurs in sepsis patients surviving the initial inflammatory cascade These are all organisms of normal virulence that cause nosocomial infections in sepsis patients because of the selection pressure of potent antibiotics and the presence of biofilm affected/colonized intravascular and urinary catheters. keywords: apoptosis; cells; cytokine; expression; immune; infection; mice; model; murine; patients; production; response; sepsis; tnf cache: cord-001293-dfaxj3bv.txt plain text: cord-001293-dfaxj3bv.txt item: #12 of 177 id: cord-001319-mlkaowqr author: Giamarellos-Bourboulis, Evangelos J title: Kinetics of circulating immunoglobulin M in sepsis: relationship with final outcome date: 2013-10-21 words: 3642 flesch: 46 summary: From all these paired comparisons, significant changes of circulating IgM were found only between severe sepsis and septic shock; IgM was significantly decreased upon worsening from severe sepsis into septic shock (P = 0.039). Our findings lead to the hypothesis that during severe sepsis lymphocytes are hypofunctional for IgM production but high circulating IgM compensates for the patient's needs; once septic shock develops circulating IgM is fully consumed and lymphocytes are completely anergic for any IgM production. keywords: blood; cells; igm; patients; production; sepsis; shock; study; survivors cache: cord-001319-mlkaowqr.txt plain text: cord-001319-mlkaowqr.txt item: #13 of 177 id: cord-001322-7xmxcm35 author: Walden, Andrew P title: Patients with community acquired pneumonia admitted to European intensive care units: an epidemiological survey of the GenOSept cohort date: 2014-04-01 words: 4294 flesch: 41 summary: In one study, the death rate of ICU patients between 28 days and 6 months was 9% in patients with sepsis, similar to the 8% seen in ICU patients without sepsis [36] and the 10% found in the present study. This compares to an increase in mortality from 18.2% at 30 days to 24.8% at 90 days in the subgroup of ICU patients in the PORT study [24] and an increase from 17.3% to 34.8% at 12 months in the GenIMS cohort of ICU patients [3] . keywords: cap; community; icu; mortality; outcome; patients; pneumonia; severe; study cache: cord-001322-7xmxcm35.txt plain text: cord-001322-7xmxcm35.txt item: #14 of 177 id: cord-001473-aki28lhp author: Chen, Qi Xing title: Silencing airway epithelial cell-derived hepcidin exacerbates sepsis-induced acute lung injury date: 2014-08-06 words: 4521 flesch: 40 summary: These results demonstrated that in the current study the intratracheal administration of Ad-shHepc1 only silenced the hepcidin gene transcription in AECs, which was in accordance with previous studies that adenovirus-mediated intratracheal gene delivery specifically inhibited targeted gene expression in lung epithelial cells but not in alveolar macrophages and other organs [29, 30] . A systematic review Mortality rates for patients with acute lung injury/ARDS have decreased over time Human defensins and LL-37 in mucosal immunity Hiemstra PS: Defensins and cathelicidins in inflammatory lung disease: beyond antimicrobial activity Expression and activity of beta-defensins and LL-37 in the developing human lung Increased levels of antimicrobial peptides in tracheal aspirates of newborn infants during infection High concentrations of alpha-defensins in plasma and bronchoalveolar lavage fluid of patients with acute respiratory distress syndrome Protection against Pseudomonas aeruginosa pneumonia and sepsis-induced lung injury by overexpression of beta-defensin-2 in rats Hepcidin and iron regulation, 10 years later Fine tuning of hepcidin expression by positive and negative regulators Hepcidin in human iron disorders: therapeutic implications Hepcidin as a therapeutic tool to limit iron overload and improve anemia in β-thalassemic mice Hepcidin and the iron-infection axis Iron in innate immunity: starve the invaders Two to tango: regulation of mammalian iron metabolism Hepcidin mediates transcriptional changes that modulate acute cytokine-induced inflammatory responses in mice Hepcidin protects against lipopolysaccharide-induced liver injury in a mouse model of obstructive jaundice Hepcidin expression in human airway epithelial cells is regulated by interferon-γ Functional differences between hepcidin 1 and 2 in transgenic mice Targeted disruption of the hepcidin 1 gene results in severe hemochromatosis Antihepcidin antibody treatment modulates iron metabolism and is effective in a mouse model of inflammation-induced anemia Triggering receptor expressed on myeloid cells-2 protects against polymicrobial sepsis by enhancing bacterial clearance Hussell T: A critical function for CD200 in lung immune homeostasis and the severity of influenza infection Hepatic iron concentration does not predict response to standard and pegylated-IFN/ribavirin therapy in patients with chronic hepatitis C Attenuation of IgG immune complex-induced acute lung injury by silencing C5aR in lung epithelial cells In vivo gene silencing (with siRNA) of pulmonary expression of MIP-2 versus KC results in divergent effects on hemorrhage-induced, neutrophil-mediated septic acute lung injury Zinc modulates the innate immune response in vivo to polymicrobial sepsis through regulation of NF-kappaB Hepcidin regulates cellular iron efflux by binding to ferroportin and inducing its internalization Hepcidin-induced endocytosis of ferroportin is dependent on ferroportin ubiquitination keywords: aecs; airway; cells; hepcidin; injury; iron; knockdown; lung; macrophages; mice; sepsis cache: cord-001473-aki28lhp.txt plain text: cord-001473-aki28lhp.txt item: #15 of 177 id: cord-001536-ta1i0ata author: Nair, Girish B title: Year in review 2013: critical care - respiratory infections date: 2014-10-29 words: 8910 flesch: 34 summary: In another study, including 350 patients, investigators using data from electronic medical records compared the incidence and outcomes in VAP patients using various definitions, including the new CDC ventilator-associated event algorithm, before and after a VAP bundle was introduced in their institution (pre-bundle period January 2003 to December 2006 (n = 213); post-bundle period January 2007 to December 2009 (n = 137)) As with the previous study, VAP patients with susceptible PA received adequate empiric antibiotic coverage more often, both empiric and definitive, than patients with MDR pathogens (68% versus 30%, P <0.001). keywords: antibiotic; icu; infection; mortality; pathogens; patients; pneumonia; risk; sepsis; study; therapy; vap; ventilator cache: cord-001536-ta1i0ata.txt plain text: cord-001536-ta1i0ata.txt item: #16 of 177 id: cord-001661-dj9bxhwb author: Kao, Kuo-Chin title: Diffuse alveolar damage associated mortality in selected acute respiratory distress syndrome patients with open lung biopsy date: 2015-05-15 words: 4386 flesch: 42 summary: Pathological findings of DAD patients had a higher hospital mortality rate than non-DAD patients (71.9 % vs 45.5 %, p = 0.007). A pathological finding of DAD in ARDS patients is associated with hospital mortality and there are no clinical characteristics that could identify DAD patients before open lung biopsy. keywords: acute; ards; biopsy; dad; distress; lung; patients; study; syndrome cache: cord-001661-dj9bxhwb.txt plain text: cord-001661-dj9bxhwb.txt item: #17 of 177 id: cord-001894-ptuelrqj author: Ferrer, Miquel title: Polymicrobial intensive care unit-acquired pneumonia: prevalence, microbiology and outcome date: 2015-12-23 words: 4163 flesch: 28 summary: Among 441 consecutive patients with ICUAP, 256 (58 %) had microbiologic confirmation, and 41 (16 %) of them polymicrobial pneumonia. Methicillin-sensitive Staphylococcus aureus, Haemophilus influenzae, and several Enterobacteriaceae were more frequent in polymicrobial pneumonia. keywords: etiology; icuap; patients; pneumonia; polymicrobial; study; treatment; ventilator cache: cord-001894-ptuelrqj.txt plain text: cord-001894-ptuelrqj.txt item: #18 of 177 id: cord-002240-38aabxh1 author: Prina, Elena title: New aspects in the management of pneumonia date: 2016-10-01 words: 4835 flesch: 30 summary: Immunomodulatory effects of macrolides during community-acquired pneumonia: a literature review Antibiotic treatment strategies for community-acquired pneumonia in adults beta-Lactam monotherapy vs beta-lactam-macrolide combination treatment in moderately severe community-acquired pneumonia: a randomized noninferiority trial Efficacy of increasing dosages of clarithromycin for treatment of experimental Mycoplasma pneumoniae pneumonia Lung inflammatory pattern and antibiotic treatment in pneumonia Systemic corticosteroids for community-acquired pneumonia: reasons for use and lack of benefit on outcome Systemic inflammatory pattern of community-acquired pneumonia (CAP) patients with and without chronic obstructive pulmonary disease (COPD) Inhaled corticosteroids and systemic inflammatory response in community-acquired pneumonia: a prospective clinical study Pneumonic and non-pneumonic exacerbations of COPD: systemic inflammatory response and clinical characteristics Immunomodulatory effects of quinolones Assessment of plasmatic immunoglobulin G, A and M levels in septic shock patients Endogenous IgG hypogammaglobulinaemia in critically ill adults with sepsis: systematic review and meta-analysis Serum immunoglobulins in the infected and convalescent phases in community-acquired pneumonia Pooled human immunoglobulin therapy in critically Ill patients with pandemic 2009 influenza A(H1N1) pneumonitis and immunoglobulin G2 subclass (IgG2) deficiency Intravenous immunoglobulin for treating sepsis, severe sepsis and septic shock Use of polyclonal immunoglobulins as adjunctive therapy for sepsis or septic shock Intravenous immunoglobulin and mortality in pneumonia patients with septic shock: an observational nationwide study Concept for a study design in patients with severe community-acquired pneumonia: a randomised controlled trial with a novel IGM-enriched immunoglobulin preparation-The CIGMA study Not applicable. In particular, high levels of interleukin (IL)-6, IL-8, and IL-10 have been detected in patients with severe pneumonia and excess IL-6 and IL-10 was associated with increased mortality (from 4.8 to 11.4 %) keywords: cap; community; corticosteroids; effects; mortality; patients; pneumonia; treatment; use cache: cord-002240-38aabxh1.txt plain text: cord-002240-38aabxh1.txt item: #19 of 177 id: cord-003307-snruk3j2 author: Schmidt, Julius J. title: Clinical course, treatment and outcome of Pneumocystis pneumonia in immunocompromised adults: a retrospective analysis over 17 years date: 2018-11-19 words: 4069 flesch: 45 summary: Cochrane HIV/AIDS Group Use of adjunctive corticosteroids in severe adult non-HIV Pneumocystis carinii pneumonia Incidence of Pneumocystis jiroveci pneumonia among groups at risk in HIV-negative patients Pneumocystis pneumonia suspected cases in 604 non-HIV and HIV patients Infectious disease ward admission positively influences P. jiroveci pneumonia (PjP) outcome: a retrospective analysis of 116 HIV-positive and HIV-negative immunocompromised patients Population-based analysis of invasive fungal infections Pneumocystis pneumonia in HIV-infected and immunocompromised non-HIV infected patients: a retrospective study of two centers in China Outcomes and prognostic factors of non-HIV patients with pneumocystis jirovecii pneumonia and pulmonary CMV co-infection: a retrospective cohort study Predisposing factors, clinical characteristics and outcome of Pneumonocystis jirovecii pneumonia in HIV-negative patients Analysis of underlying diseases and prognosis factors associated with Pneumocystis carinii pneumonia in immunocompromised HIV-negative patients Intensive care of patients with HIV infection: utilization, critical illnesses, and outcomes. However, when ICU patients were analyzed separately, we observed that the addition of age as a variable increased the predictive performance of LDH alone from an AUC of 0.61 (95% CI 0.49-0.72) to an AUC of 0.71 (95% CI 0.60-0.81) (p = 0.024). keywords: hiv; hospital; ldh; mortality; non; patients; pcp; pneumocystis; pneumonia cache: cord-003307-snruk3j2.txt plain text: cord-003307-snruk3j2.txt item: #20 of 177 id: cord-003376-2qi4aibx author: van de Groep, Kirsten title: Effect of cytomegalovirus reactivation on the time course of systemic host response biomarkers in previously immunocompetent critically ill patients with sepsis: a matched cohort study date: 2018-12-18 words: 3893 flesch: 38 summary: Patients with CMV reactivation had a more pronounced increase of IP-10 (median percentage difference of 44% versus −15%) and decrease of IL-1RA (median percentage difference of −41% versus 0%) on day 7 after viremia onset compared with CMV seropositive patients without reactivation. Based on previous studies in ICU patients, there is a clear pathophysiological link between inflammation and immune suppression on the one hand and the subsequent risk of CMV reactivation on the other keywords: biomarkers; cmv; comparison; cytomegalovirus; icu; patients; reactivation; study; time cache: cord-003376-2qi4aibx.txt plain text: cord-003376-2qi4aibx.txt item: #21 of 177 id: cord-003416-c22kw6f4 author: Baek, Moon Seong title: Improvement in the survival rates of extracorporeal membrane oxygenation-supported respiratory failure patients: a multicenter retrospective study in Korean patients date: 2019-01-03 words: 3060 flesch: 39 summary: Despite such limitations, our current multicenter study, which is not based on the ELSO registry, provides information on the change in the survival rate of ECMO patients with respiratory failure and the factors associated with survival, and adds to the understanding of survival in patients who receive ECMO due to respiratory failure. Also, another explanation for the relatively low survival rate of Korean ECMO patients could be the infrequent use of prone positioning. keywords: ecmo; failure; patients; rate; study; survival cache: cord-003416-c22kw6f4.txt plain text: cord-003416-c22kw6f4.txt item: #22 of 177 id: cord-003513-hmdikgf5 author: Cillóniz, Catia title: Multidrug Resistant Gram-Negative Bacteria in Community-Acquired Pneumonia date: 2019-03-09 words: 5542 flesch: 29 summary: Since antibiotic treatment for P. aeruginosa is completely different from standard therapy to cover the most common pathogens in CAP, current international guidelines for severe CAP stratify therapy recommendations on the basis of P. aeruginosa risk factors [1] . The prevalence of antibiotic-resistant P. aeruginosa in CAP was 1.6% in Europe, 2.5% in North America, 2.2% in Asia, 3.0% in South America, and 3.9% in Africa; there were no reported cases of P. aeruginosa antibiotic resistance in Oceania. keywords: aeruginosa; antibiotic; baumannii; cap; factors; mdr; patients; pneumonia; risk cache: cord-003513-hmdikgf5.txt plain text: cord-003513-hmdikgf5.txt item: #23 of 177 id: cord-003532-lcgeingz author: None title: 39th International Symposium on Intensive Care and Emergency Medicine: Brussels, Belgium, 19-22 March 2019 date: 2019-03-19 words: 80115 flesch: 48 summary: Blood cultures were sent as per clinical & laboratory diagnosis of sepsis in ICU patients. Conclusions: HR, lactate levels and age before AVP initiation can predict the response to AVP in ICU patients with NE-resistant hypotension. keywords: acute; admission; age; aim; aki; analysis; arrest; arterial; assessment; baseline; blood; cardiac; care; care unit; cases; clinical; complications; conclusions; correlation; critical; data; days; diagnosis; difference; discharge; ecmo; effect; emergency; factors; failure; fig; figure; fluid; group; high; hospital; hospital mortality; hours; icu; icu admission; icu patients; ill; incidence; increase; injury; intensive; intervention; introduction; lactate; length; levels; low; lung; management; map; mean; median; medical; methods; months; mortality; non; organ; outcome; patients; patients introduction; period; post; pressure; rate; ratio; response; results; resuscitation; risk; score; sepsis; sepsis patients; septic; serum; severity; shock patients; sofa; stay; studies; study; surgery; survival; system; table; test; therapy; time; total; trauma; treatment; ultrasound; unit; use; ventilation; years cache: cord-003532-lcgeingz.txt plain text: cord-003532-lcgeingz.txt item: #24 of 177 id: cord-003701-i70ztypg author: Chow, Eric J. title: Influenza virus-related critical illness: prevention, diagnosis, treatment date: 2019-06-12 words: 6873 flesch: 16 summary: • Enterically administered oseltamivir is recommended for influenza patients except for those with contraindications (e.g., gastric stasis, ileus, malabsorption). In particular, a large pooled individual patient-level meta-analysis of observational studies from 38 countries identified a 38% reduction in risk of mortality in critically ill adults and those aged ≥ 16 years old when comparing early NAI treatment (< 48 h) with later treatment (> 48 h), and a 69% reduction in mortality risk between influenza patients receiving early NAI treatment and those who did not receive NAIs [72] . keywords: adults; infection; influenza; mortality; oseltamivir; patients; risk; studies; study; treatment; virus cache: cord-003701-i70ztypg.txt plain text: cord-003701-i70ztypg.txt item: #25 of 177 id: cord-003832-q1422ydi author: Koyama, Kansuke title: Biomarker profiles of coagulopathy and alveolar epithelial injury in acute respiratory distress syndrome with idiopathic/immune-related disease or common direct risk factors date: 2019-08-19 words: 4663 flesch: 34 summary: A secondary analysis of the LUNG SAFE study confirmed that 8.3% of ARDS patients had no common risk factors that were identified when ARDS was recognized [6] . Thrombin-antithrombin complex (TAT) levels are increased in ARDS patients, reflecting tissue factor-and contact phase-mediated activation of coagulation cascade and excessive thrombin generation. keywords: acute; ards; biomarkers; factors; injury; lung; patients; pneumonia; respiratory; risk; study cache: cord-003832-q1422ydi.txt plain text: cord-003832-q1422ydi.txt item: #26 of 177 id: cord-003870-hr99dwi7 author: Clohisey, Sara title: Host susceptibility to severe influenza A virus infection date: 2019-09-05 words: 6002 flesch: 38 summary: IFITM3 has also been recently shown to have a protective effect on the heart during severe IAV infection. A more recent study of Han Chinese individuals that looked at several genes confirmed an association between CD55 rs2564978 T/T and death from severe IAV infection [72] . keywords: associated; cell; disease; gene; host; iav; infection; influenza; pandemic; risk; study; susceptibility; virus cache: cord-003870-hr99dwi7.txt plain text: cord-003870-hr99dwi7.txt item: #27 of 177 id: cord-003995-53115c1c author: Guerci, Philippe title: Outcomes of Stenotrophomonas maltophilia hospital-acquired pneumonia in intensive care unit: a nationwide retrospective study date: 2019-11-21 words: 5435 flesch: 32 summary: Each medical record was analyzed by local investigators to determine if clinical, biological, and/or radiological signs of S. maltophilia HAP were present, thus excluding respiratory tract colonizations (defined as a positive respiratory sample without clinical, biological, and/or radiological signs of S. maltophilia pneumonia). Indeed, different regimens were used in our population, with various durations of treatment before S. maltophilia HAP diagnosis without apparent consequences on S. maltophilia emergence and susceptibility profiles. keywords: care; diagnosis; hap; hospital; maltophilia; patients; pneumonia; stenotrophomonas; study; table; therapy cache: cord-003995-53115c1c.txt plain text: cord-003995-53115c1c.txt item: #28 of 177 id: cord-004096-obrq7q57 author: Benghanem, Sarah title: Brainstem dysfunction in critically ill patients date: 2020-01-06 words: 5812 flesch: 31 summary: Opioids might also contribute to brainstem dysfunction, as they depress the ARAS, respiratory centers, and brainstem reflexes (notably pupillary light and cough reflexes). key: cord-004096-obrq7q57 authors: Benghanem, Sarah; Mazeraud, Aurélien; Azabou, Eric; Chhor, Vibol; Shinotsuka, Cassia Righy; Claassen, Jan; Rohaut, Benjamin; Sharshar, Tarek title: Brainstem dysfunction in critically ill patients date: 2020-01-06 journal: Crit Care DOI: 10.1186/s13054-019-2718-9 sha: doc_id: 4096 cord_uid: obrq7q57 The brainstem conveys sensory and motor inputs between the spinal cord and the brain, and contains nuclei of the cranial nerves. keywords: brainstem; consciousness; dysfunction; illness; impairment; inflammatory; lesions; mortality; motor; nerve; nuclei; patients; reflexes; table cache: cord-004096-obrq7q57.txt plain text: cord-004096-obrq7q57.txt item: #29 of 177 id: cord-004147-9bcq3jnm author: Fernando, Shannon M. title: New-onset atrial fibrillation and associated outcomes and resource use among critically ill adults—a multicenter retrospective cohort study date: 2020-01-13 words: 4163 flesch: 41 summary: We determined patient costs using the case-costing system of the Ottawa Hospital Data Warehouse, as done previously [17, 23, 27] . Finally, comparisons of patient costs between patients with and without NOAF are shown in Table 5 Table S6 ). keywords: costs; data; hospital; icu; mortality; noaf; patients; sepsis cache: cord-004147-9bcq3jnm.txt plain text: cord-004147-9bcq3jnm.txt item: #30 of 177 id: cord-004263-m1ujhhsc author: Koekkoek, W. A. C. title: The effect of cisatracurium infusion on the energy expenditure of critically ill patients: an observational cohort study date: 2020-02-03 words: 3157 flesch: 40 summary: A reliable estimation of the energy expenditure (EE) of ICU patients may help to avoid these phenomena. However, this hypothesis has not been studied in ICU patients with the previously described indications for the use of continuous NMBA infusion. keywords: cisatracurium; infusion; kcal; patients; study cache: cord-004263-m1ujhhsc.txt plain text: cord-004263-m1ujhhsc.txt item: #31 of 177 id: cord-004268-raayrjmd author: Flattres, Aurelien title: Real-time shear wave ultrasound elastography: a new tool for the evaluation of diaphragm and limb muscle stiffness in critically ill patients date: 2020-02-03 words: 4598 flesch: 40 summary: Few others have assessed inter-operator and intra-operator reliability in measuring muscle shear modulus and have reported similar results. Impact of inspiratory effort Mechanical ventilation and diaphragmatic atrophy in critically ill patients: an ultrasound study The course of diaphragm atrophy in ventilated patients assessed with ultrasound: a longitudinal cohort study Skeletal muscle ultrasound in critical care: a tool in need of translation Shear wave sonoelastography of skeletal muscle: basic principles, biomechanical concepts, clinical applications, and future perspectives Noninvasive assessment of muscle stiffness in patients with Duchenne muscular dystrophy Shear wave elastography is a reliable and repeatable method for measuring the elastic modulus of the rectus femoris muscle and patellar tendon: shear wave elastography of the rectus femoris muscle and patellar tendon Ultrasound shear wave velocity in skeletal muscle: a reproducibility study Ultrasound shear wave elastography in assessment of muscle stiffness in patients with Parkinson's disease: a primary observation Rapid disuse atrophy of diaphragm fibers in mechanically ventilated humans Diaphragm muscle fiber weakness and ubiquitinproteasome activation in critically ill patients Critical illness-associated diaphragm weakness Diaphragmatic myotrauma: a mediator of prolonged ventilation and poor patient outcomes in acute respiratory failure Diaphragmatic shear modulus at various submaximal inspiratory mouth pressure levels The effect of unit, depth, and probe load on the reliability of muscle shear wave elastography: variables affecting reliability of SWE Publisher's Note Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations We would like to thank Claudine Gniadek, RN, and the members of the medical and nursing team for their participation in the present study. keywords: diaphragm; intra; modulus; muscle; operator; patients; reliability; shear; study; swe; wave cache: cord-004268-raayrjmd.txt plain text: cord-004268-raayrjmd.txt item: #32 of 177 id: cord-004299-ydm6j046 author: Lu, Yifang title: New-onset atrial fibrillation can be falsely associated with increased length of stay in ICU due to immortal time bias date: 2020-02-06 words: 948 flesch: 47 summary: While the conclusion appeared intuitive and statistically sound, it could be the result of immortal time bias. Lu and Chen suggest caution in the interpretation of our study results, particularly as they relate to the length of stay and costs, due to the possibility of immortal time bias. keywords: noaf; time cache: cord-004299-ydm6j046.txt plain text: cord-004299-ydm6j046.txt item: #33 of 177 id: cord-004327-ofqay81v author: Wu, Tung-Ho title: Facilitating ventilator weaning through rib fixation combined with video-assisted thoracoscopic surgery in severe blunt chest injury with acute respiratory failure date: 2020-02-12 words: 3862 flesch: 52 summary: A prospective randomized study of management of severe flail chest patients The role of thoracoscopy in the management of retained thoracic collections after trauma Management of posttraumatic retained hemothorax: a prospective, observational, multicenter AAST study Effectiveness of surgical rib fixation on prolonged mechanical ventilation in patients with traumatic rib fractures: a propensity score-matched analysis Chest wall stabilization in ventilator-dependent traumatic flail chest patients: who benefits? key: cord-004327-ofqay81v authors: Wu, Tung-Ho; Lin, Hsing-Lin; Chou, Yi-Pin; Huang, Fong-Dee; Huang, Wen-Yen; Tarng, Yih-Wen title: Facilitating ventilator weaning through rib fixation combined with video-assisted thoracoscopic surgery in severe blunt chest injury with acute respiratory failure date: 2020-02-12 journal: Crit Care DOI: 10.1186/s13054-020-2755-4 sha: doc_id: 4327 cord_uid: ofqay81v BACKGROUND: Severe blunt chest injury sometimes induces acute respiratory failure (ARF), requiring ventilator use. keywords: chest; fixation; patients; rib; study; trauma; vats; ventilator cache: cord-004327-ofqay81v.txt plain text: cord-004327-ofqay81v.txt item: #34 of 177 id: cord-004422-oep1grwq author: Li, Yuting title: Comparison of T-piece and pressure support ventilation as spontaneous breathing trials in critically ill patients: a systematic review and meta-analysis date: 2020-02-26 words: 3263 flesch: 44 summary: The analysis of secondary outcomes also shows no significant difference in the rate of reintubation, ICU and hospital length of stay, and ICU and Managing the apparent and hidden difficulties of weaning from mechanical ventilation Extubation failure after successful spontaneous breathing trial: prediction is still a challenge! key: cord-004422-oep1grwq authors: Li, Yuting; Li, Hongxiang; Zhang, Dong title: Comparison of T-piece and pressure support ventilation as spontaneous breathing trials in critically ill patients: a systematic review and meta-analysis date: 2020-02-26 journal: Crit Care DOI: 10.1186/s13054-020-2764-3 sha: doc_id: 4422 cord_uid: oep1grwq BACKGROUND: keywords: extubation; patients; piece; rate; ventilation cache: cord-004422-oep1grwq.txt plain text: cord-004422-oep1grwq.txt item: #35 of 177 id: cord-004427-dy9v9asg author: Bissell, Brittany D. title: Impact of protocolized diuresis for de-resuscitation in the intensive care unit date: 2020-02-28 words: 4712 flesch: 33 summary: The overall management of patients outside of diuresis protocol was left to physician discretion. Supplementary Digital Content This file includes relevant study protocols, definitions, as well as subgroup analyses and additional informational tables beyond manuscript content. keywords: balance; days; diuresis; fluid; group; icu; intervention; patients; protocol; study cache: cord-004427-dy9v9asg.txt plain text: cord-004427-dy9v9asg.txt item: #36 of 177 id: cord-005495-0mi0n2zn author: De Laet, Inneke E. title: A Clinician’s Guide to Management of Intra-abdominal Hypertension and Abdominal Compartment Syndrome in Critically Ill Patients date: 2020-03-24 words: 4821 flesch: 31 summary: ACS abdominal compartment syndrome, IAP intra-abdominal pressure if the potential for serious complications can be avoided by this strategy. Morbid obesity causes chronic increase of intra-abdominal pressure It's high time for intra-abdominal hypertension guidelines in pregnancy after more than 100 years of measuring pressures Renal resistive index and renal function before and after paracentesis in patients with hepatorenal syndrome and tense ascites Abdominal contributions to cardiorenal dysfunction in congestive heart failure The significance of intra-abdominal pressure in neurosurgery and neurological diseases: a narrative review and a conceptual proposal The duration of intra-abdominal hypertension strongly predicts outcomes for the critically ill surgical patients: a prospective observational study Intra-abdominal hypertension and abdominal compartment syndrome Intra-abdominal hypertension and acute renal failure in critically ill patients Renal implications of increased intra-abdominal pressure: are the kidneys the canary for abdominal hypertension? keywords: abdominal; acs; compartment; dysfunction; iah; iap; organ; patients; syndrome cache: cord-005495-0mi0n2zn.txt plain text: cord-005495-0mi0n2zn.txt item: #37 of 177 id: cord-005496-cnwg4dnn author: Gutierrez, Guillermo title: Artificial Intelligence in the Intensive Care Unit date: 2020-03-24 words: 5014 flesch: 38 summary: For those wishing to delve deeper into the development of machine learning models, a good source of information is the book by Müller and Guido Machine learning models have also been proposed to predict mortality in trauma [25] and pediatric ICU patients keywords: algorithm; care; data; icu; information; learning; machine; model; patients; variables cache: cord-005496-cnwg4dnn.txt plain text: cord-005496-cnwg4dnn.txt item: #38 of 177 id: cord-005497-w81ysjf9 author: None title: 40th International Symposium on Intensive Care & Emergency Medicine: Brussels, Belgium. 24-27 March 2020 date: 2020-03-24 words: 103795 flesch: 50 summary: Conclusions: This is one of the first studies to demonstrate that abnormal RV function is associated with an increased mortality in ICU patients with pneumonia. The fast efficacy of targeted therapies led some intensivists to use them as rescue therapy for ICU patients. keywords: acute; administration; admission; adult patients; age; aim; aki; aki patients; analysis; approach; arrest; arterial; associated; association; average; baseline; blood; cardiac; care; care patients; care unit; cases; clinical; cohort; cohort study; complications; control; critical; critical care; data; day mortality; days; death; delirium; difference; discharge; disease; early; ecmo; effect; emergency; factors; failure; figure; fluid; function; group; hospital; hospital mortality; hours; icu admission; icu mortality; icu patients; icu stay; ill; incidence; increase; index; infection; injury; intensive; introduction; length; levels; low; lps; lung; management; mean; median; medical; methods; min; model; months; mortality; non; number; observational; organ; outcome; pain; parameters; patients; period; plasma; population; positive; post; pressure; rate; renal; results; risk; score; sepsis; sepsis patients; septic; serum; shock; shock patients; sofa; stay; studies; study; support; surgery; survival; table; test; therapy; time; total; treatment; unit; university; use; value; ventilation; volume; years cache: cord-005497-w81ysjf9.txt plain text: cord-005497-w81ysjf9.txt item: #39 of 177 id: cord-005503-hm8tvkt3 author: Rasulo, Frank A. title: Essential Noninvasive Multimodality Neuromonitoring for the Critically Ill Patient date: 2020-03-24 words: 5991 flesch: 31 summary: Pupil examination: validity and clinical utility of an automated pupillometer Reliability of standard pupillometry practice in neurocritical care: An observational, double-blinded study Pupillometric analysis of the 'absent light reflex Neurological prognostication of outcome in patients in coma after cardiac arrest Infrared pupillometry to detect the light reflex during cardiopulmonary resuscitation: a case series Quantitative pupillometry and neuronspecific enolase independently predict return of spontaneous circulation following cardiogenic out-of-hospital cardiac arrest: a prospective pilot study Quantitative versus standard pupillary light reflex for early prognostication in comatose cardiac arrest patients: an international prospective multicentre double-blinded study Variation in monitoring and treatment policies for intracranial hypertension in traumatic brain injury: a survey in 66 neurotrauma centers participating in the CENTER-TBI study Infrared pupillometry during uncal herniation Prognosis and clinical relevance of anisocoria-craniotomy latency for epidural hematoma in comatose patients Use of admission Glasgow Coma Score, pupil size, and pupil reactivity to determine outcome for trauma patients Effects of osmotic therapy on pupil reactivity: quantification using pupillometry in critically ill neurologic patients Optical pupillometry in traumatic brain injury: neurological pupil index and its relationship with intracranial pressure through significant event analysis Quantitative pupillometry for the monitoring of intracranial hypertension in patients with severe traumatic brain injury Automated pupillometry to detect command following in neurological patients: a proof-of-concept study Pupillary reflex measurement predicts insufficient analgesia before endotracheal suctioning in critically ill patients Reflex pupillary dilatation in response to skin incision and alfentanil in children anaesthetized with sevoflurane: a more sensitive measure of noxious stimulation than the commonly used variables Pupillary dilation reflex and pupillary pain index evaluation during general anaesthesia: a pilot study Pupillometry-guided intraoperative remifentanil administration versus standard practice influences opioid use: a randomized study Noninvasive transcranial Doppler ultrasound recording of flow velocity in basal cerebral arteries Transcranial color-coded duplex sonography fir bedside monitoring of central nervous system infection as a consequence of decompressive craniectomy after traumatic brain injury Non-invasive intracranial pressure assessment in brain injured patients using ultrasound-based methods Optic nerve sheath diameter on computed tomography is correlated with simultaneously measured intracranial pressure in patients with severe traumatic brain injury Cerebral perfusion pressure in head-injured patients: a noninvasive assessment using transcranial Doppler ultrasonography The accuracy of transcranial Doppler in excluding intracranial hypertension following acute brain injury: a multicenter prospective pilot study Transcranial Doppler Pulsatility in vasodilation and stenosis Consensus summary statement of the international multidisciplinary consensus conference on multimodality monitoring in neurocritical care Cerebral vasospasm after subarachnoid hemorrhage investigated by means of transcranial Doppler ultrasound Basilar vasospasm diagnosis: investigation of a modified Lindegaard Index based on imaging studies and blood velocity measurements of the basilar artery Transcranial color-coded duplex sonography for evaluation of midline-shift after chronic-subdural hematoma evacuation (TEMASE): A prospective study Accuracy of Power mode transcranial Doppler in the diagnosis of brain death Standardized care versus precision medicine in the perioperative setting: Can point-of-care testing help bridge the gap? A primer for EEG signal processing in anesthesia Electroencephalography and brain oxygenation monitoring in the perioperative period Beyond its use for sedative titration purposes, processed EEG may have some additional applications in ICU patients, including identification of subclinical/ unrecognized seizures or seizures occurring when neuromuscular blocking agents are administered. keywords: brain; eeg; fig; flow; icp; icu; light; monitoring; patients; pupillary; pupillometry; reflex; sedation; transcranial cache: cord-005503-hm8tvkt3.txt plain text: cord-005503-hm8tvkt3.txt item: #40 of 177 id: cord-007550-2b62zaur author: Buchtele, Nina title: Feasibility and safety of watershed detection by contrast-enhanced ultrasound in patients receiving peripheral venoarterial extracorporeal membrane oxygenation: a prospective observational study date: 2020-04-02 words: 1119 flesch: 41 summary: The watershed is marked with an arrow and located distal to the superior mesenteric artery Extracorporeal membrane oxygenation watershed Heart against venoarterial ECMO: competition visualized Hemodynamic changes in patients with extracorporeal membrane oxygenation (ECMO) demonstrated by contrast-enhanced CT examinations -implications for image acquisition technique Safety and feasibility of contrast echocardiography for ECMO evaluation Safety and feasibility of contrast echocardiography for LVAD evaluation Acute kidney injury is associated with a decrease in cortical renal perfusion during septic shock Publisher's Note Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations The feasibility of CEUS was assessed based on qualitative image evaluation, the amount of contrast media administered, and the rate of bubble detection. keywords: ceus; contrast; patients; watershed cache: cord-007550-2b62zaur.txt plain text: cord-007550-2b62zaur.txt item: #41 of 177 id: cord-009274-32adi3hb author: Hu, Bo title: Effect of initial infusion rates of fluid resuscitation on outcomes in patients with septic shock: a historical cohort study date: 2020-04-07 words: 4402 flesch: 48 summary: We also compared data distributions across fluid resuscitation rate groups using chi-square and Kruskal-Wallis tests for categorical and continuous data, respectively. The goal of this investigation is to examine the relationship between fluid resuscitation rate and septic shock resolution. keywords: fluid; patients; rate; resuscitation; shock; time cache: cord-009274-32adi3hb.txt plain text: cord-009274-32adi3hb.txt item: #42 of 177 id: cord-010055-exi8t6jt author: Zhu, Guang-wen title: Whether the GFR measured by renal scintigraphy under non-steady state conditions for critically ill patients with AKI can be used as a predictive parameter for clinical events date: 2020-04-19 words: 837 flesch: 38 summary: These findings were most consistent with renal causes of acute renal failure Determining the optimal time for liberation from renal replacement therapy in critically ill patients: a systematic review and meta-analysis (DOnE RRT) Estimating and measuring glomerular filtration rate: methods of measurement and markers for estimation The SNMMI and EANM practice guideline for renal scintigraphy in adults ACR Appropriateness Criteria(®) radiologic management of central venous access Publisher's Note Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations None. Although renal scintigraphy is rarely used clinically for critically ill patients with AKI, partly because of a lack of understanding of the technology, it can actually provide unique kidneys' function parameters, split renal function, and GFRs. keywords: aki; gfr; scintigraphy cache: cord-010055-exi8t6jt.txt plain text: cord-010055-exi8t6jt.txt item: #43 of 177 id: cord-010697-0eutz8xy author: Roumy, Aurélien title: Pulmonary complications associated with veno-arterial extra-corporeal membrane oxygenation: a comprehensive review date: 2020-05-11 words: 5398 flesch: 26 summary: In case of chronic decrease of pulmonary blood flow (e.g., in chronic thromboembolic disease or pulmonary stenosis), the bronchial flow may increase from 1 to 30% of the cardiac output, permitting to compensate this decrease and participate to gas exchange, providing a kind of rescue flow to the ischemic areas [55, 56] . Ventilation with high positive end-expiratory pressure (PEEP) might also impede pulmonary blood flow by compression of alveolar vessels [58] . keywords: alveolar; blood; ecmo; extracorporeal; flow; lung; membrane; oxygenation; patients; pulmonary; support cache: cord-010697-0eutz8xy.txt plain text: cord-010697-0eutz8xy.txt item: #44 of 177 id: cord-014464-m5n250r2 author: Sole-Violan, J title: Lethal influenza virus A H1N1 infection in two relatives with autosomal dominant GATA-2 deficiency date: 2013-03-19 words: 99097 flesch: 51 summary: The application of the endotoxin activity assay was useful for bedside monitoring of endotoxemia in ICU patients. The aim of this study is to describe the clinical and epidemiological profi le of ICU patients receiving tigecycline (TGC) and to evaluate the potential benefi ts of TGC higher doses. keywords: acute; admission; adult patients; age; aim; analysis; blood; brain; cardiac; care; care patients; cases; clinical; conclusion; confi; control; criteria; critical; data; days; defi; diff; dose; early; ect; eff; emergency; erence; erent; failure; fi rst; figure; function; group; guidelines; high; hospital; hospital mortality; hours; icu admission; icu mortality; icu patients; icu stay; icus; identifi; increase; infl; injury; intensive; introduction; length; levels; low; lung; management; mean; median; medical; methods; methods patients; minutes; months; mortality; n =; number; nurses; organ; outcome; p =; patients; period; post; pressure; protocol; rate; renal; response; results; risk; rst; score; sepsis; septic; severity; shock; shock patients; signifi; stay; studies; study; surgery; surgery patients; surgical; test; therapy; time; total; treatment; uid; use; ventilation; volume; years cache: cord-014464-m5n250r2.txt plain text: cord-014464-m5n250r2.txt item: #45 of 177 id: cord-027526-ohcu28rk author: Zhou, Xiaoyang title: Preventive use of respiratory support after scheduled extubation in critically ill medical patients—a network meta-analysis of randomized controlled trials date: 2020-06-22 words: 6439 flesch: 43 summary: Respiratory support has been widely applied to prevent post-extubation respiratory failure, treat respiratory failure that developed after extubation, or facilitate early weaning from IMV in patients who have failed SBT [12] . This network meta-analysis (NMA) aims to evaluate the comparative effectiveness of various respiratory support methods used for preventive purposes after scheduled extubation in critically ill medical patients. keywords: cot; evidence; extubation; failure; hfot; niv; patients; risk; trials cache: cord-027526-ohcu28rk.txt plain text: cord-027526-ohcu28rk.txt item: #46 of 177 id: cord-028337-md9om47x author: Ketcham, Scott W. title: Causes and characteristics of death in patients with acute hypoxemic respiratory failure and acute respiratory distress syndrome: a retrospective cohort study date: 2020-07-03 words: 4755 flesch: 42 summary: We sought to determine the causes and circumstances of death in a contemporary cohort of AHRF patients, and assess whether causes of death differed among patients with and without ARDS. Despite increased attention to earlier identification and treatment of sepsis in the intervening decades [17, 18] , our study found that sepsis remained the most common cause of death in AHRF patients. keywords: ahrf; ards; death; dysfunction; organ; patients; sepsis; support cache: cord-028337-md9om47x.txt plain text: cord-028337-md9om47x.txt item: #47 of 177 id: cord-028835-jby1btv7 author: Rilinger, Jonathan title: Prone positioning in severe ARDS requiring extracorporeal membrane oxygenation date: 2020-07-08 words: 3905 flesch: 49 summary: Sedation for PP patients at our institution was titrated to preserve spontaneous breathing if possible. However, it seems reasonable that PP patients might have been on deeper sedation levels than patients in the supine group. keywords: ards; ecmo; patients; support; survival; vs. cache: cord-028835-jby1btv7.txt plain text: cord-028835-jby1btv7.txt item: #48 of 177 id: cord-029183-3aotgq6m author: Monard, Céline title: Multicenter evaluation of a syndromic rapid multiplex PCR test for early adaptation of antimicrobial therapy in adult patients with pneumonia date: 2020-07-14 words: 5860 flesch: 30 summary: Therefore, in pneumonia patients, international guidelines state that an attempt should be made to obtain respiratory samples and recommend to start early empirical treatment while awaiting for the results of culture and antimicrobial susceptibility testing (AST) Second, although we included a large panel of pneumonia patients (severe ICU patients with VAP or HAP and non-severe CAP patients from the emergency room), it remains unclear what group of patients will benefit most from the syndromic rm-PCR diagnosis. keywords: antibiotic; committee; culture; episodes; pathogens; patients; pcr; pneumonia; results; therapy cache: cord-029183-3aotgq6m.txt plain text: cord-029183-3aotgq6m.txt item: #49 of 177 id: cord-029516-tj93wo1s author: Chelly, Jonathan title: Automated vs. conventional ventilation in the ICU: a randomized controlled crossover trial comparing blood oxygen saturation during daily nursing procedures (I-NURSING) date: 2020-07-22 words: 4414 flesch: 42 summary: IOSR JNHS Safety and efficacy of a fully closed-loop control ventilation (IntelliVent-ASV(R)) in sedated ICU patients with acute respiratory failure: a prospective randomized crossover study Evaluation of fully automated ventilation: a randomized controlled study in post-cardiac surgery patients Prospective randomized crossover study of a new closed-loop control system versus pressure support during weaning from mechanical ventilation Fully automated closed-loop ventilation is safe and effective in post-cardiac surgery patients Feasibility study on full closed-loop control ventilation (IntelliVent-ASV) in ICU patients with acute respiratory failure: a prospective observational comparative study Closed-loop ventilation mode (IntelliVent®-ASV) in intensive care unit: a randomized trial of ventilation delivered Closed loop ventilation mode in intensive care unit: a randomized controlled clinical trial comparing the numbers of manual ventilator setting changes Airway and transpulmonary driving pressures and mechanical powers selected by INTELLiVENT-ASV in passive, mechanically ventilated ICU patients Effect of conservative vs conventional oxygen therapy on mortality among patients in an intensive care unit: the oxygen-ICU randomized clinical trial British Thoracic Society Guideline for oxygen use in adults in healthcare and emergency settings Positional hypoxemia during artificial ventilation Lateral positioning of ventilated intensive care patients: a study of oxygenation, respiratory mechanics, hemodynamics, and adverse events Effects of patients positioning on respiratory mechanics in mechanically ventilated ICU patients The effect of patient positioning on dynamic lung compliance Prevention of endotracheal suctioning-induced alveolar derecruitment in acute lung injury A meta-analysis of the effects of various interventions in preventing endotracheal suction-induced hypoxemia Changes in lung volume with three systems of endotracheal suctioning with and without pre-oxygenation in patients with mild-to-moderate lung failure Ventilator-related causes of lung injury: the mechanical power Comparative evaluation of accuracy of pulse oximeters and factors affecting their performance in a tertiary intensive care unit Publisher's Note Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations We are indebted to Caroline Huber-Brown for editorial assistance. 2 Comparison between conventional and automated ventilation in terms of minimal, mean, and maximal blood oxygen saturation (SpO 2 ) during daily nursing procedures (*p < 0.05) Creating the animated intensive care unit Strategies for post ICU rehabilitation Body positioning of intensive care patients: clinical practice versus standards A prospective observational study of ICU patient position and frequency of turning Increased splanchnic oxygen extraction because of routine nursing procedures Body position change and its effect on hemodynamic and metabolic status Secondary insults related to nursing interventions in neurointensive care: a descriptive pilot study The effect of nursing interventions on the intracranial pressure in paediatric traumatic brain injury Decreasing severe pain and serious adverse events while moving intensive care unit patients: a prospective interventional study (the NURSE-DO project) Physiological changes associated with routine nursing procedures in critically ill are common: an observational pilot study Daily nursing care on patients undergoing venous-venous extracorporeal membrane oxygenation: a challenging procedure Oxygen desaturation and nursing practices in critically ill patients. keywords: blood; desaturation; dnps; oxygen; patients; spo cache: cord-029516-tj93wo1s.txt plain text: cord-029516-tj93wo1s.txt item: #50 of 177 id: cord-029991-0sy417j0 author: Longhini, Federico title: Chest physiotherapy improves lung aeration in hypersecretive critically ill patients: a pilot randomized physiological study date: 2020-08-03 words: 4621 flesch: 34 summary: Compared to T0, ΔEELI significantly increased in hypersecretive patients at T2 and T3, irrespective of the RM; on the contrary, no differences were observed in normosecretive patients. Hypersecretive patients showed higher ΔEELI at T2 and T3, as opposed to the respective time points in normosecretive patients (Table 2 ; Fig. 2 ). keywords: airway; application; chest; data; hfcwo; hypersecretive; impedance; lung; patients; study; ventilation cache: cord-029991-0sy417j0.txt plain text: cord-029991-0sy417j0.txt item: #51 of 177 id: cord-030131-klhg7x8z author: Tan, Dingyu title: High-flow nasal cannula oxygen therapy versus non-invasive ventilation for chronic obstructive pulmonary disease patients after extubation: a multicenter, randomized controlled trial date: 2020-08-06 words: 4589 flesch: 40 summary: Due to intolerance, drinking and eating, sputum clearance, communication, discomfort, or displacement of the NIV mask, NIV patients frequently remove their masks and significantly increase the nursing workload [28] . Ninety-six patients were randomly assigned to the HFNC group or NIV group. keywords: extubation; failure; group; hfnc; niv; patients; respiratory; ventilation cache: cord-030131-klhg7x8z.txt plain text: cord-030131-klhg7x8z.txt item: #52 of 177 id: cord-030277-x9zvx3fp author: Ohta, Yoshinori title: Effect of dexmedetomidine on inflammation in patients with sepsis requiring mechanical ventilation: a sub-analysis of a multicenter randomized clinical trial date: 2020-08-10 words: 4083 flesch: 47 summary: The percentage of patients with three or more SIRS characteristics did not differ significantly between the DEX vs. non-DEX group (range, 12-71 vs. 19-74%; P = 0.15). The DESIRE trial was a multicenter randomized clinical trial in which adult patients with sepsis were sedated with (DEX group) or without (non-DEX group) dexmedetomidine while on mechanical ventilators. keywords: day; dex; dexmedetomidine; group; levels; mortality; non; patients; sepsis cache: cord-030277-x9zvx3fp.txt plain text: cord-030277-x9zvx3fp.txt item: #53 of 177 id: cord-030677-t94cu81n author: Burstein, Barry title: Association between mean arterial pressure during the first 24 hours and hospital mortality in patients with cardiogenic shock date: 2020-08-20 words: 4079 flesch: 43 summary: The findings of our study indirectly support the safety of a lower MAP target (i.e., 65-70 mmHg) in CS patients, but did not show a benefit of higher MAP targets among patients with a history of hypertension. Using a single-center database of CICU patients admitted between 2007 and 2015, we identified patients with an admission diagnosis of CS. keywords: hospital; map; mmap; mmhg; mortality; patients cache: cord-030677-t94cu81n.txt plain text: cord-030677-t94cu81n.txt item: #54 of 177 id: cord-031033-v4yetn4f author: Martin-Loeches, Ignacio title: The importance of airway and lung microbiome in the critically ill date: 2020-08-31 words: 5112 flesch: 20 summary: This link needs to be further explored before we can conclude that lung microbiome dysbiosis is a potential target for treatment (Fig. 1) . To date, more than 30 studies have used sensitive, culture-independent techniques to study lung bacteria in healthy volunteers, and none has failed to detect a distinct bacterial signal [21] . keywords: ards; bacteria; gut; host; lung; lung microbiome; microbial; microbiome; patients; pneumonia; study cache: cord-031033-v4yetn4f.txt plain text: cord-031033-v4yetn4f.txt item: #55 of 177 id: cord-034948-w59wxu8i author: Kuriyama, Akira title: Performance of the cuff leak test in adults in predicting post-extubation airway complications: a systematic review and meta-analysis date: 2020-11-07 words: 4776 flesch: 43 summary: We included studies that examined the diagnostic accuracy of cuff leak test if post-extubation airway obstruction after extubation or reintubation was explicitly reported as the reference standard. The pooled sensitivity and specificity of cuff leak test for post-extubation airway obstruction were 0.62 (95% CI 0.49–0.73; I(2) = 81.6%) and 0.87 (95% CI 0.82–0.90; I(2) = 97.8%), respectively. keywords: airway; cuff; extubation; leak; obstruction; post; studies; test cache: cord-034948-w59wxu8i.txt plain text: cord-034948-w59wxu8i.txt item: #56 of 177 id: cord-048199-5yhe786e author: Alvarez, Gonzalo title: Debate: Transfusing to normal haemoglobin levels will not improve outcome date: 2001-03-08 words: 4653 flesch: 40 summary: A once and future risk? Immunosuppressive effects of blood transfusion in anaesthesia and surgery Transfusion-induced immunosuppression Effect of blood transfusions on subsequent kidney transplants Annotation. Currently, the risk of transmitting an infectious agent through blood transfusion ranges from 1:100,000 for hepatitis B virus to 1:1,000,000 for HIV (Canadian Blood Services, personal communication, 2000). keywords: blood; disease; mortality; patients; strategy; transfusion cache: cord-048199-5yhe786e.txt plain text: cord-048199-5yhe786e.txt item: #57 of 177 id: cord-048343-nzk8m912 author: Milbrandt, Eric B title: Bench-to-bedside review: Critical illness-associated cognitive dysfunction – mechanisms, markers, and emerging therapeutics date: 2006-11-15 words: 5793 flesch: 28 summary: An experimental study in dogs Cerebral hemodynamics, vascular reactivity, and metabolism during canine endotoxin shock Group B streptococcal sepsis impairs cerebral vascular reactivity to acute hypercarbia in piglets Neuropathology of septic shock Multifocal necrotizing leukoencephalopathy in septic shock Apoptosis of neurons in cardiovascular autonomic centres triggered by inducible nitric oxide synthase after death from septic shock The neuropathology of septic shock The role of hypotension in septic encephalopathy following surgical procedures Cerebral circulation and metabolism in patients with septic encephalopathy Different C-reactive protein kinetics in post-operative hip-fractured geriatric patients with and without complications The role of oxidative stress in postoperative delirium Regional cerebral blood flow in delirium patients Neuropsychological sequelae and impaired health status in survivors of severe acute respiratory distress syndrome Hyperglycemia and neurocognitive outcome in ARDS survivors Hyperglycemia augments ischemic brain injury: in vivo MR imaging/spectroscopic study with nicardipine in cats with occluded middle cerebral arteries Signs of brain cell injury during open heart operations: past and present Release of glial tissue-specific proteins after acute stroke: a comparative analysis of serum concentrations of protein S-100B and glial fibrillary acidic protein Is there an association between release of protein S100B during cardiopulmonary bypass and memory disturbances? Although there are no studies evaluating the effectiveness of cognitive rehabilitation in patients recovering from non-neurologic critical illness, it stands to reason that such patients could benefit when they are found to be cognitively impaired. keywords: acute; anticholinergic; brain; delirium; icu; illness; injury; levels; mechanisms; patients; serum; studies; study cache: cord-048343-nzk8m912.txt plain text: cord-048343-nzk8m912.txt item: #58 of 177 id: cord-048447-chz8luni author: Duffett, Mark title: Surfactant therapy for acute respiratory failure in children: a systematic review and meta-analysis date: 2007-06-15 words: 3999 flesch: 33 summary: We selected search terms from the keywords and MESH terms of previous surfactant trials and from the generic and brand names of commercially available surfactants. We searched the MEDLINE, EMBASE, CINAHL and Ovid Healthstar databases, the bibliographies of included trials and review articles, conference proceedings and trial registries. keywords: acute; children; failure; patients; surfactant; trials; ventilation cache: cord-048447-chz8luni.txt plain text: cord-048447-chz8luni.txt item: #59 of 177 id: cord-048448-kfwbqp4p author: Sandrock, Christian title: Clinical review: Update of avian influenza A infections in humans date: 2007-03-22 words: 4457 flesch: 40 summary: The appearance of H3 influenza viruses in seals Are seals frequently infected with avian influenza viruses? Characterization of an influenza A virus from seals Transmission of equine influenza virus to dogs Avian influenza H5N1 in viverrids: implications for wildlife health and conservation Characterization of an avian influenza A virus isolated from a human -is an intermediate host necessary for the emergence of pandemic influenza viruses Human influenza A H5N1 virus related to a highly pathogenic avian influenza virus Avian influenza A virus (H7N7) associated with human conjunctivitis and a fatal case of acute respiratory distress syndrome Characterization of an avian influenza A (H5N1) virus isolated from a child with a fatal respiratory illness Evolution and ecology of influenza A viruses Antigenic and genetic characterization of a novel hemagglutinin subtype of influenza A viruses from gulls Molecular characterization of a new hemagglutinin, subtype H14, of influenza A virus Characterization of a novel influenza hemagglutinin, H15: criteria for determination of influenza A subtypes Investigation of outbreaks of highly pathogenic H5N1 avian influenza in waterfowl and wild birds in Hong Kong in late Highly pathogenic H5N1 influenza virus infection in migratory birds Reemerging H5N1 viruses in Hong Kong in 2002 are highly pathogenic to ducks Genesis of a highly pathogenic and potentially pandemic H5N1 virus in eastern Asia New genotype of avian influenza H5N1 viruses isolated from tree sparrows in China Characterization of H5N1 influenza A viruses isolated during the 2003-2004 influenza outbreaks in Japan. Pathology of fatal human infection associated with avian influenza A H5N1 virus Risk of influenza A (H5N1) infection among poultry workers Development of a realtime reverse transcriptase PCR assay for type A influenza virus and the avian H5 and H7 hemagglutinin subtypes Application of real-time RT-PCR for the quantitation and competitive replication study of H5 and H7 subtype avian influenza virus Single-step multiplex reverse transcription-polymerase chain reaction (RT-PCR) for influenza A virus subtype H5N1 detection The World Health Organization Global Influenza Program Surveillance Network: Evolution of H5N1 avian influenza viruses in Asia Emergence of drug-resistant influenza virus: population dynamical considerations Antiviral agents. keywords: avian; cases; disease; h5n1; health; hpai; human; infection; influenza; virus; viruses cache: cord-048448-kfwbqp4p.txt plain text: cord-048448-kfwbqp4p.txt item: #60 of 177 id: cord-048449-mzn448zk author: Challen, Kirsty title: Clinical review: Mass casualty triage – pandemic influenza and critical care date: 2007-04-30 words: 4260 flesch: 41 summary: Properly constructed plans for the delivery of critical care during an influenza pandemic must include the ability to deal with excessive demand, high and possibly extreme mortality, and the risk to the health of critical care staff. Other staff may need to be redeployed and receive training in the management of critical care patients to support fully trained staff, permitting a dilution of the standard critical care nurse to patient ratio [23] . keywords: care; critical; health; hospital; influenza; level; pandemic; patients; planning; staff; triage cache: cord-048449-mzn448zk.txt plain text: cord-048449-mzn448zk.txt item: #61 of 177 id: cord-104180-f3hoz9bu author: Kirk-Bayley, Justin title: Recently published papers: inflammation, elucidation, manipulation? date: 2003-07-03 words: 1549 flesch: 37 summary: Glucocorticoid insufficiency in patients who present to the hospital with severe sepsis: a prospective clinical trial Adrenocortical hormones in survivors and nonsurvivors of severe sepsis: diverse time course of dehydroepiandrosterone, dehydroepiandrosterone-sulfate, and cortisol Stress doses of hydrocortisone reduce severe systemic inflammatory response syndrome and improve early outcome in a risk group of patients after cardiac surgery Coagulation blockade prevents sepsis-induced respiratory and renal failure in baboons Blockade of tissue factor: treatment for organ injury in established sepsis Development of ionized hypomagnesemia is associated with higher mortality rates Injurious mechanical ventilation and end-organ epithelial cell apoptosis and organ dysfunction in an experi-Critical Care Effect of mechanical ventilation on inflammatory mediators in patients with acute respiratory distress syndrome: a randomized controlled trial Prevention of endotracheal suctioning-induced alveolar derecruitment in acute lung injury Dose-response characteristics during long-term inhalation of nitric oxide in patients with severe acute respiratory distress syndrome: a prospective, randomized, controlled study Effects of dopamine, norepinephrine, and epinephrine on the splanchnic circulation in septic shock: Which is best? Bad medicine: low-dose dopamine in the ICU On the physiologic and clinical relevance of lung-borne cytokines during ventilator-induced lung injury Discrepancies between perceptions by physicians and nursing staff of intensive care unit end-of-life decisions A randomized trial of inhaled nitric oxide to prevent ischemia-reperfusion injury after lung transplantation Activated protein C inhibits the expression of platelet-derived growth factor in the lung Treatment of acute respiratory distress syndrome with recombinant surfactant protein C surfactant Impact of randomized trial results on acute lung injury ventilator therapy in teaching hospitals None declared. Looking at reduced endogenous steroid levels in sepsis, Marx and coworkers [2] focused on the androgens dehydroepiandrosterone (DHEA) and its sulphated precursor (DHEAS) and looked at disparity between survivors and nonsurvivors from severe sepsis. keywords: levels; lung; patients; sepsis cache: cord-104180-f3hoz9bu.txt plain text: cord-104180-f3hoz9bu.txt item: #62 of 177 id: cord-252473-i4pmux28 author: Rogers, Sharon title: Why can't I visit? The ethics of visitation restrictions – lessons learned from SARS date: 2004-08-31 words: 1911 flesch: 39 summary: The ethics of visitation restrictions – lessons learned from SARS date: 2004-08-31 journal: Crit Care DOI: 10.1186/cc2930 sha: doc_id: 252473 cord_uid: i4pmux28 Patients want, need and expect that their relatives will be able to visit them during inpatient admissions or accompany them during ambulatory visits. This reflection will facilitate future decision making with respect to visitation restrictions. keywords: health; restrictions; sars; visitation cache: cord-252473-i4pmux28.txt plain text: cord-252473-i4pmux28.txt item: #63 of 177 id: cord-252890-of29g89s author: Villarreal-Fernandez, Eduardo title: A plea for avoiding systematic intubation in severely hypoxemic patients with COVID-19-associated respiratory failure date: 2020-06-12 words: 1023 flesch: 38 summary: Patient 1 was extubated at day 16, while the second patient was still intubated at day 19 (when this report was submitted) Clinical course and outcomes of critically ill patients with SARS-CoV-2 pneumonia in Wuhan, China: a single-centered, retrospective, observational study Clinical management of severe acute respiratory infection (SARI) when COVID-19 disease is suspected Staff safety during emergency airway management for COVID-19 in Hong Kong Aerosol generating procedures and risk of transmission of acute respiratory infections to healthcare workers: a systematic review High-flow nasal therapy in adults with severe acute respiratory infection: a cohort study in patients with 2009 influenza A/ H1N1v Publisher's Note Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations Not applicable. However, we reconsidered in other patients the rationale behind these early intubations and revisited the initial proposal of avoiding high flow oxygen in hypoxemic patients. keywords: intubation; patients cache: cord-252890-of29g89s.txt plain text: cord-252890-of29g89s.txt item: #64 of 177 id: cord-253006-r2a2ozrc author: Yan, Xiquan title: Duration of SARS-CoV-2 viral RNA in asymptomatic carriers date: 2020-05-24 words: 494 flesch: 49 summary: The long duration of asymptomatic infection with SARS-CoV-2 may warrant a reassessment of quarantine as the current outbreak. [2] , and the relatively high proportion of asymptomatic infections could have public health implications keywords: asymptomatic; sars cache: cord-253006-r2a2ozrc.txt plain text: cord-253006-r2a2ozrc.txt item: #65 of 177 id: cord-254287-8q2gdy5n author: Azoulay, Elie title: International variation in the management of severe COVID-19 patients date: 2020-08-05 words: 1326 flesch: 46 summary: There are important practice variations in the management of severe COVID-19 patients, including differences at regional and individual levels. This survey highlights important practice variations in the management of severe COVID-19 patients, including differences at regional and individual levels. keywords: covid-19; management; patients cache: cord-254287-8q2gdy5n.txt plain text: cord-254287-8q2gdy5n.txt item: #66 of 177 id: cord-255216-87ursh0s author: de Castro, Isabel Fernández title: First evidence of a pro-inflammatory response to severe infection with influenza virus H1N1 date: 2010-02-11 words: 1314 flesch: 45 summary: The roles of IL-17A in infl ammatory immune responses and host defense against pathogens IL-17 and Th17 cells Critical role of IL-17RA in immunopathology of infl uenza infection Macrolides for the treatment of severe respiratory illness caused by novel H1N1 swine infl uenza viral strains This work was supported by grants from Instituto de Salud Carlos III (PI08/0738; UIPY 1467/07) to SR. rst that describes an association between severe infl uenza infection and a Th 17 response in humans. keywords: infection; infl; nvh1n1 cache: cord-255216-87ursh0s.txt plain text: cord-255216-87ursh0s.txt item: #67 of 177 id: cord-256237-xiv9vxdp author: Suntharalingam, Ganesh title: Scanning the horizon: emerging hospital-wide technologies and their impact on critical care date: 2005-01-13 words: 2441 flesch: 32 summary: Several countries have developed national horizon scanning systems to identify and monitor new health technologies. Health technology assessment encompasses the best use of current health care devices as well as emerging technologies. keywords: care; glucose; health; national; systems; technologies; technology cache: cord-256237-xiv9vxdp.txt plain text: cord-256237-xiv9vxdp.txt item: #68 of 177 id: cord-257361-7q0vbvvd author: Lee, James S. title: Critical care for COVID-19 during a humanitarian crisis—lessons learnt from Yemen date: 2020-09-23 words: 1297 flesch: 47 summary: Invasive mechanical ventilation (IMV) received global attention but is only the visible tip of the iceberg for COVID-19 care. Routine ICU care, such as ventilator settings, ventilator-associated pneumonia prevention bundles, infusion pump usage, and early mobility, amongst others, were unfamiliar. keywords: care; icu; oxygen; patients cache: cord-257361-7q0vbvvd.txt plain text: cord-257361-7q0vbvvd.txt item: #69 of 177 id: cord-258087-93yfs7ve author: Flores, Carlos title: A quality assessment of genetic association studies supporting susceptibility and outcome in acute lung injury date: 2008-10-25 words: 4740 flesch: 28 summary: Positive genetic association studies with acute lung injury/acute respiratory distress syndrome susceptibility and/or outcome (by year of publication) Percentage of studies scored as adequate for 14 criteria (x-axis) used for the quality assessment of genetic association studies supporting susceptibility and/or outcome in acute lung injury Percentage of studies scored as adequate for 14 criteria (x-axis) used for the quality assessment of genetic association studies supporting susceptibility and/or outcome in acute lung injury. key: cord-258087-93yfs7ve authors: Flores, Carlos; del Mar Pino-Yanes, Maria; Villar, Jesús title: A quality assessment of genetic association studies supporting susceptibility and outcome in acute lung injury date: 2008-10-25 journal: Crit Care DOI: 10.1186/cc7098 sha: doc_id: 258087 cord_uid: 93yfs7ve INTRODUCTION: keywords: acute; ali; ards; association; genetic; injury; lung; outcome; studies; susceptibility cache: cord-258087-93yfs7ve.txt plain text: cord-258087-93yfs7ve.txt item: #70 of 177 id: cord-259747-sl9q63oc author: Remmelink, Myriam title: Unspecific post-mortem findings despite multiorgan viral spread in COVID-19 patients date: 2020-08-12 words: 4549 flesch: 43 summary: key: cord-259747-sl9q63oc authors: Remmelink, Myriam; De Mendonça, Ricardo; D’Haene, Nicky; De Clercq, Sarah; Verocq, Camille; Lebrun, Laetitia; Lavis, Philomène; Racu, Marie-Lucie; Trépant, Anne-Laure; Maris, Calliope; Rorive, Sandrine; Goffard, Jean-Christophe; De Witte, Olivier; Peluso, Lorenzo; Vincent, Jean-Louis; Decaestecker, Christine; Taccone, Fabio Silvio; Salmon, Isabelle title: Unspecific post-mortem findings despite multiorgan viral spread in COVID-19 patients date: 2020-08-12 journal: Crit Care DOI: 10.1186/s13054-020-03218-5 sha: doc_id: 259747 cord_uid: sl9q63oc BACKGROUND: Post-mortem studies can provide important information for understanding new diseases and small autopsy case series have already reported different findings in COVID-19 patients. Most of the previous post-mortem studies in COVID-19 patients were conducted using needle biopsies and were therefore rather limited in terms of sampling; our complete autopsy analysis identified considerable heterogeneity of SARS-CoV-2 spread through the human body and provides a more accurate description of macroscopic and microscopic organ alterations. keywords: acute; covid-19; findings; lung; organs; patients; pcr; samples; sars; study cache: cord-259747-sl9q63oc.txt plain text: cord-259747-sl9q63oc.txt item: #71 of 177 id: cord-260069-v5qvqxgy author: Yuan, Shou-Tao title: Practice of novel method of bedside postpyloric tube placement in patients with coronavirus disease 2019 date: 2020-04-07 words: 636 flesch: 56 summary: First, the price of Flocare tube (approximately $22) is 1/3 less compared with spiral tube (approximately $71) in China. key: cord-260069-v5qvqxgy authors: Yuan, Shou-Tao; Zhang, Wen-Hao; Zou, Lei; Sun, Jia-Kui; Liu, Ying; Shi, Qian-Kun title: Practice of novel method of bedside postpyloric tube placement in patients with coronavirus disease 2019 date: 2020-04-07 journal: Crit Care DOI: 10.1186/s13054-020-02863-0 sha: doc_id: 260069 cord_uid: v5qvqxgy nan Practice of novel method of bedside postpyloric tube placement in patients with coronavirus disease 2019 Shou-Tao Yuan 1,2 , Wen-Hao Zhang 1,2 , Lei Zou 1,2 , Jia-Kui Sun 1,2* , Ying Liu 1,2 and Qian-Kun Shi 1, 2 During our clinical work against the epidemic of coronavirus disease 2019 (COVID-19) in Wuhan [1] , we observed a high incidence of malnutrition in critically ill patients (data unpublished). keywords: patients; tube cache: cord-260069-v5qvqxgy.txt plain text: cord-260069-v5qvqxgy.txt item: #72 of 177 id: cord-260215-gsnjlhjd author: Dhanani, Jayesh title: Fundamentals of aerosol therapy in critical care date: 2016-10-07 words: 8323 flesch: 32 summary: The efficacy of aerosol drug therapy depends on drug-related factors (particle size, molecular weight), device factors, patient-related factors (airway anatomy, inhalation patterns) and mechanical ventilation-related factors (humidification, airway). Figure 2 shows the factors conducive for effective aerosol drug delivery in the critically ill mechanically ventilated and non-mechanically ventilated patient groups. keywords: aerosol; care; delivery; deposition; drug; effect; factors; flow; lung; nebulizers; patients; pneumonia; studies; therapy; use; ventilation cache: cord-260215-gsnjlhjd.txt plain text: cord-260215-gsnjlhjd.txt item: #73 of 177 id: cord-260822-4bselbkq author: Lotz, Christopher title: Unconventional approaches to mechanical ventilation—step-by-step through the COVID-19 crisis date: 2020-05-18 words: 1191 flesch: 40 summary: Ventilator triage would likely require switching of the ventilators during the course of treatment according to disease severity and stage as well as weaning capabilities, e.g., from anesthesia ventilator to ICU ventilator. ICU ventilators provide the highest performance, fast responding efficient triggering mechanisms, and often a plethora of different ventilation modes to best suit the individual patient. keywords: icu; patients; ventilation; ventilators cache: cord-260822-4bselbkq.txt plain text: cord-260822-4bselbkq.txt item: #74 of 177 id: cord-262489-cecg3geg author: Zhao, Zhanqi title: COVID-19 pneumonia: phenotype assessment requires bedside tools date: 2020-05-29 words: 893 flesch: 45 summary: The disease status of COVID-19 patients developed rapidly. Bedside tools such as EIT and ultrasound may play an important role in identifying different phenotypes for COVID-19 patients. keywords: covid-19; lung; patients cache: cord-262489-cecg3geg.txt plain text: cord-262489-cecg3geg.txt item: #75 of 177 id: cord-263346-pu1jci26 author: Peng, Qian-Yi title: Using echocardiography to guide the treatment of novel coronavirus pneumonia date: 2020-04-10 words: 1038 flesch: 28 summary: Fast identify the circulatory status and the types of shock According to the pathophysiological mechanism of shock, it can be divided into 4 types: distributed shock, cardiogenic shock, hypovolemic shock, and obstructive shock. In COVID-19 patients, the most common types of shock are septic shock and cardiogenic shock; however, we still need to exclude obstructive shock (massive pericardial effusion, right heart collapse, heart swing, RV enlargement and D sign, tricuspid valve regurgitation, pulmonary artery or deep vein thrombosis, etc.) and hypovolemic shock (decrease of CO, papillary muscle kissing sign, IVC collapse and high respiratory variability, etc.) keywords: function; heart; patients; shock cache: cord-263346-pu1jci26.txt plain text: cord-263346-pu1jci26.txt item: #76 of 177 id: cord-263568-ea3k2i69 author: Price, Elizabeth title: Could the severity of COVID-19 be increased by low gastric acidity? date: 2020-07-22 words: 766 flesch: 51 summary: As well as protection related to immunological factors and possible differences in the ACE2 receptor concentrations in their lungs, children (other than infants) generally have good levels of gastric acid. To determine whether gastric acid gives some protection from COVID-19, the amount of antacids and acid-reducing drugs used by patients with severe infections could be compared with the amount used by patients with mild or no disease. keywords: covid-19; gastric cache: cord-263568-ea3k2i69.txt plain text: cord-263568-ea3k2i69.txt item: #77 of 177 id: cord-265022-p5cab562 author: Kotfis, Katarzyna title: COVID-19: ICU delirium management during SARS-CoV-2 pandemic date: 2020-04-28 words: 5433 flesch: 28 summary: The Intensive Care Delirium Screening Checklist (ICDSC)--translation and validation of intensive care delirium checklist in accordance with guidelines A novel coronavirus from patients with pneumonia in China Early transmission dynamics in Wuhan, China, of novel coronavirus-infected pneumonia Clinical features of patients infected with 2019 novel coronavirus in Wuhan Fair Allocation of Scarce Medical Resources in the Time of Covid-19 Sedative and analgesic medications are independent risk factors in ICU patients for transitioning into delirium Use of medications with anticholinergic effect predicts clinical severity of delirium symptoms in older medical inpatients Caring for critically ill patients with the ABCDEF bundle: results of the ICU liberation collaborative in over 15,000 adults The ABCDEF bundle: science and philosophy of how ICU liberation serves patients and families Improving hospital survival and reducing brain dysfunction at seven California community hospitals: implementing PAD guidelines via the ABCDEF bundle in 6,064 patients Clinical and team management in the COVID-ICU: successful strategies from the first week Organ distribution of severe acute respiratory syndrome (SARS) associated coronavirus (SARS-CoV) in SARS patients: implications for pathogenesis and virus transmission pathways Multiple organ infection and the pathogenesis of SARS Neurotropic virus tracing suggests a membranous-coatingmediated mechanism for transsynaptic communication SARS: clinical features and diagnosis The neuroinvasive potential of SARS-CoV2 may play a role in the respiratory failure of COVID-19 patients Mechanisms of host defense following severe acute respiratory syndrome-coronavirus (SARS-CoV) pulmonary infection of mice Neuroinvasion by human respiratory coronaviruses Middle East respiratory syndrome coronavirus causes multiple organ damage and lethal disease in mice transgenic for human Dipeptidyl peptidase 4 Novel coronavirus is putting the whole world on alert Neurotropism of human coronavirus 229E Characteristics of a coronavirus (strain 67N) of pigs Detection of coronavirus in the central nervous system of a child with acute disseminated encephalomyelitis Neurologic complications of coronavirus infections Coronavirus infections in the central nervous system and respiratory tract show distinct features in hospitalized children COVID-19-associated Acute Hemorrhagic Necrotizing Encephalopathy: CT and MRI Features. However, the standard of care for ICU patients, including delirium management, must remain the highest quality possible with an eye towards long-term survival and minimization of issues related to post-intensive care syndrome (PICS). keywords: acute; brain; care; coronavirus; cov-2; covid-19; delirium; icu; management; patients; risk; sars; unit cache: cord-265022-p5cab562.txt plain text: cord-265022-p5cab562.txt item: #78 of 177 id: cord-267348-bkirv9pt author: Sakano, Takashi title: Above and beyond: biofilm and the ongoing search for strategies to reduce ventilator-associated pneumonia (VAP) date: 2020-08-18 words: 577 flesch: 35 summary: Table 1 summarizes the mechanism, preventive measures, and methods that have been investigated to prevent aspiration and minimize biofilm burden related to tracheal seeding, microaspiration, biofilm formation, ciliary dysfunction, and the cough reflex. [1] that compared biofilm formation on three endotracheal tube (ETT) types with the finding that biofilm formation was reduced in silicone and noble-metal coated ETTs compared to uncoated ETTs. keywords: biofilm; vap cache: cord-267348-bkirv9pt.txt plain text: cord-267348-bkirv9pt.txt item: #79 of 177 id: cord-267942-ykl2xy7y author: Stiers, Michiel title: Successful ventilation of two animals with a single ventilator: individualized shared ventilator setup in an in vivo model date: 2020-08-27 words: 1018 flesch: 45 summary: key: cord-267942-ykl2xy7y authors: Stiers, Michiel; Bleeser, Tom; Mergeay, Matthias; Pinson, Hannah; Janssen, Luc; Schepens, Tom title: Successful ventilation of two animals with a single ventilator: individualized shared ventilator setup in an in vivo model date: 2020-08-27 journal: Crit Care DOI: 10.1186/s13054-020-03248-z sha: doc_id: 267942 cord_uid: ykl2xy7y nan Dear Editor, As the ongoing COVID-19 crisis is spreading from developed into developing nations, a shortage of ventilators in ICUs can be expected during peak prevalence. Ventilator settings and measurements are shown in Table 1 . keywords: animal; tidal; ventilator cache: cord-267942-ykl2xy7y.txt plain text: cord-267942-ykl2xy7y.txt item: #80 of 177 id: cord-270298-zv0t3d0m author: Bouch, Christopher title: Recently published papers: pulmonary care, pandemics, and eugenics in surviving sepsis? date: 2006-02-01 words: 1667 flesch: 44 summary: Interestingly, haplogroup H patients generated significantly higher temperatures than patients with differing haplogroups. Scrupulous infection control practice, above and beyond the normal, by all in contact with at risk patients. keywords: difficile; hcap; patients; pneumonia; vap cache: cord-270298-zv0t3d0m.txt plain text: cord-270298-zv0t3d0m.txt item: #81 of 177 id: cord-271751-46oo9xv5 author: Ingraham, Nicholas E. title: Shining a light on the evidence for hydroxychloroquine in SARS-CoV-2 date: 2020-04-28 words: 1115 flesch: 48 summary: In the hydroxychloroquine group, 5 of 26 (19.2%) of COVID-19 patients suffered death, medical deterioration, or adverse event compared with 0 (0%) in the control arm (Barnard's test: p = 0.07) with a number needed to harm (NNH) of 5.2. key: cord-271751-46oo9xv5 authors: Ingraham, Nicholas E.; Boulware, David; Sparks, Matthew A.; Schacker, Timothy; Benson, Bradley; Sparks, Jeffrey A.; Murray, Thomas; Connett, John; Chipman, Jeffrey G.; Charles, Anthony; Tignanelli, Christopher J. title: Shining a light on the evidence for hydroxychloroquine in SARS-CoV-2 date: 2020-04-28 journal: Crit Care DOI: 10.1186/s13054-020-02894-7 sha: doc_id: 271751 cord_uid: 46oo9xv5 nan The 2020 COVID-19 pandemic has stunned the world, financial markets, and healthcare systems. keywords: covid-19; hydroxychloroquine; patients; sars cache: cord-271751-46oo9xv5.txt plain text: cord-271751-46oo9xv5.txt item: #82 of 177 id: cord-275012-fkawgh0e author: Tavazzi, Guido title: Inhaled nitric oxide in patients admitted to intensive care unit with COVID-19 pneumonia date: 2020-08-17 words: 678 flesch: 43 summary: Overall, iNO did not improve oxygenation in COVID-19 patients with refractory hypoxaemia, when administered as a rescue treatment after prone position. All patients required iNO for refractory hypoxaemia of whom 4 (25%) had also superimposed RV dysfunction, in 1 case associated with pulmonary embolism. keywords: covid-19; ino; patients cache: cord-275012-fkawgh0e.txt plain text: cord-275012-fkawgh0e.txt item: #83 of 177 id: cord-275154-vwnpred5 author: Bermejo-Martin, Jesus F title: Th1 and Th17 hypercytokinemia as early host response signature in severe pandemic influenza date: 2009-12-11 words: 4654 flesch: 41 summary: Increase of IL-17 and TNF-α in hospitalized patients over control indicated that they also parallel severe disease, but the significantly higher levels of IL-17 and TNF-α in severe non critical patients compared to mild (difference not found for critical ones), could reflect a beneficial role of these cytokines in this particular subset of patients. Severe patients required hospitalization (n = 20), due to respiratory insufficiency (10 of them were admitted to the intensive care unit), while mild patients had exclusively flu-like symptoms (n = 15). keywords: cytokines; disease; hospitalized; infection; influenza; levels; mediators; nvh1n1; patients; responses; serum; virus cache: cord-275154-vwnpred5.txt plain text: cord-275154-vwnpred5.txt item: #84 of 177 id: cord-276561-b4cspbuf author: Liaudet, Lucas title: Blocking mineralocorticoid receptor with spironolactone may have a wide range of therapeutic actions in severe COVID-19 disease date: 2020-06-08 words: 785 flesch: 21 summary: In turn, the degradation of angiotensin II (AT II) into angiotensin 1-7 (AT 1-7 ) is prevented (dotted lines), reducing anti-inflammatory signaling through the Mas receptor (MasR), and promoting pro-inflammatory AT II signaling through the angiotensin receptor type I (AT1R) in vascular endothelial cells. MR activation polarizes macrophages towards the M1 pro-inflammatory phenotype (M1Mϕ), favors CD4 + lymphocytes differentiation towards pro-inflammatory Th17 cells, and induces cytotoxic IFNγ + keywords: receptor cache: cord-276561-b4cspbuf.txt plain text: cord-276561-b4cspbuf.txt item: #85 of 177 id: cord-276856-88d3vzbs author: Petersen, Lonnie G. title: Single ventilator for multiple patients during COVID19 surge: matching and balancing patients date: 2020-06-18 words: 646 flesch: 42 summary: One-way valves on both inspiratory and expiratory limbs ensured unidirectional flow, which both reduces functional dead space and the risk of crosscontamination between patient A and B, and seemingly also facilitated stable ventilation of B as A deteriorated. key: cord-276856-88d3vzbs authors: Petersen, Lonnie G.; Friend, James; Merritt, Sidney title: Single ventilator for multiple patients during COVID19 surge: matching and balancing patients date: 2020-06-18 journal: Crit Care DOI: 10.1186/s13054-020-03041-y sha: doc_id: 276856 cord_uid: 88d3vzbs nan With a potential COVID19-induced ventilator shortage, supporting multiple patients on a single ventilator seems a simple solution to maximize resources. keywords: cmh; patients; ventilator cache: cord-276856-88d3vzbs.txt plain text: cord-276856-88d3vzbs.txt item: #86 of 177 id: cord-276904-lmqschxy author: Courcelle, Romain title: Neuromuscular blocking agents (NMBA) for COVID-19 acute respiratory distress syndrome: a multicenter observational study date: 2020-07-19 words: 1037 flesch: 53 summary: 276904 cord_uid: lmqschxy nan The benefit of neuromuscular blocking agents (NMBA) in acute respiratory distress syndrome (ARDS) is debated Mechanical ventilation tended to be longer in survivors with long NMBA administration. keywords: nmba; patients; study cache: cord-276904-lmqschxy.txt plain text: cord-276904-lmqschxy.txt item: #87 of 177 id: cord-278249-vvhq9vgp author: Blot, Mathieu title: CXCL10 could drive longer duration of mechanical ventilation during COVID-19 ARDS date: 2020-11-02 words: 6261 flesch: 38 summary: COVID-19 ARDS patients required mechanical ventilation (MV) for significantly longer, even after adjustment for potential confounders. It should be evaluated as a candidate biomarker that may predict the duration of MV in COVID-19 ARDS patients. keywords: ards; ards patients; concentrations; covid-19; covid-19 ards; csf; cxcl10; cytokine; dna; elf; immune; non; patients; plasma; sars cache: cord-278249-vvhq9vgp.txt plain text: cord-278249-vvhq9vgp.txt item: #88 of 177 id: cord-278838-qraq5aho author: Mirouse, Adrien title: Severe varicella-zoster virus pneumonia: a multicenter cohort study date: 2017-06-07 words: 4705 flesch: 40 summary: Patients receiving steroids were matched in a 1:6 ratio to a control group of patients within this cohort who did not receive steroids. Patients receiving steroids were matched in a 1:6 ratio to a control group of patients within this cohort who did not receive steroids. keywords: admission; cap; icu; infection; patients; pneumonia; steroids; study; ventilation; vzv cache: cord-278838-qraq5aho.txt plain text: cord-278838-qraq5aho.txt item: #89 of 177 id: cord-280129-a97rvtzl author: Honore, Patrick M. title: Liver injury without liver failure in COVID-19 patients: how to explain, in some cases, elevated ammonia without hepatic decompensation date: 2020-06-16 words: 555 flesch: 40 summary: In our large cohort of COVID-19 patients, we had several patients who did not regain consciousness as expected, even when sedation had been stopped for 4-5 days. key: cord-280129-a97rvtzl authors: Honore, Patrick M.; Barreto Gutierrez, Leonel; Kugener, Luc; Redant, Sebastien; Attou, Rachid; Gallerani, Andrea; De Bels, David title: Liver injury without liver failure in COVID-19 patients: how to explain, in some cases, elevated ammonia without hepatic decompensation date: 2020-06-16 journal: Crit Care DOI: 10.1186/s13054-020-03088-x sha: doc_id: 280129 cord_uid: a97rvtzl nan Liver injury without liver failure in COVID-19 patients: how to explain, in some cases, elevated ammonia without hepatic decompensation Patrick M. Honore * , Leonel Barreto Gutierrez, Luc Kugener, Sebastien Redant, Rachid Attou, Andrea Gallerani and David De Bels We read with great interest the recent research letter by Cardoso et al. who describe the liver injury seen with COVID-19 keywords: liver; patients cache: cord-280129-a97rvtzl.txt plain text: cord-280129-a97rvtzl.txt item: #90 of 177 id: cord-280233-avmisu31 author: Chase, J. Geoffrey title: Safe doubling of ventilator capacity: a last resort proposal for last resorts date: 2020-05-14 words: 1644 flesch: 50 summary: In-parallel is a critical point, as inspiration and expiration all take place at the same time, so there is thus no change to respiratory rate (RR) and tidal volume or driving pressure are adjusted for the number of patients. In-series breathing means only 1 circuit volume (split between patients) is active at a time, but each patient's inspiratory effort is singular. keywords: patients; pressure; ventilator; volume cache: cord-280233-avmisu31.txt plain text: cord-280233-avmisu31.txt item: #91 of 177 id: cord-280278-gq1hnnwh author: Chi, Meng title: A simple custom appliance against droplet and aerosol transmission of COVID-19 during advanced airway management date: 2020-06-08 words: 808 flesch: 44 summary: Our appliance reduces the spread of droplets and aerosols from patients, blocking the airborne transmission route of the virus to a large extent and providing a new layer of protection for health care workers during advanced airway management. key: cord-280278-gq1hnnwh authors: Chi, Meng; Lou, Changming; Zhao, Xiuli; Sui, Xin; Han, Fei title: A simple custom appliance against droplet and aerosol transmission of COVID-19 during advanced airway management date: 2020-06-08 journal: Crit Care DOI: 10.1186/s13054-020-02985-5 sha: doc_id: 280278 cord_uid: gq1hnnwh nan Health care workers are exposed to high-risk environments when patients infected with COVID-19 require advanced airway management. keywords: intubation; patient cache: cord-280278-gq1hnnwh.txt plain text: cord-280278-gq1hnnwh.txt item: #92 of 177 id: cord-281191-n9gerpwy author: Herridge, Margaret S title: Autopsy in critical illness: is it obsolete? date: 2003-09-26 words: 1191 flesch: 47 summary: That is not to say that these observations are uninformative, but it does mean that most autopsy study data suffer from selection bias and this has to be considered when one discusses study results and their implications. It will include a brief discussion of selection bias in autopsy studies, the important role autopsy plays in tracking disease prevalence over time, its characterization of newly emerging diseases, its contribution to education and quality control programs, and its role in clinical decision-making. keywords: autopsy; data; patients cache: cord-281191-n9gerpwy.txt plain text: cord-281191-n9gerpwy.txt item: #93 of 177 id: cord-281663-c2okrt2b author: Sella, Nicolò title: Positive end-expiratory pressure titration in COVID-19 acute respiratory failure: electrical impedance tomography vs. PEEP/FiO(2) tables date: 2020-09-01 words: 712 flesch: 44 summary: PEEP EIT was compared with PEEP from higher and lower PEEP/ FiO 2 tables [6] . 1 Bland-Altman plot, evaluating the agreement between PEEP EIT and the PEEP values proposed by the higher (a) and lower (b) PEEP/FiO 2 tables from the ALVEOLI trial [6] . keywords: eit; patients; peep cache: cord-281663-c2okrt2b.txt plain text: cord-281663-c2okrt2b.txt item: #94 of 177 id: cord-281711-whr4pfx9 author: Joebges, Susanne title: Ethics guidelines on COVID-19 triage—an emerging international consensus date: 2020-05-06 words: 1388 flesch: 48 summary: WHO.int2004 Clinical ethics recommendation for the allocation of intensive care treatments, in exceptional COVID-19 pandemic: triage for intensive-care treatment under resource scarcity OEGARI. This can lead to a shortage of ventilators and intensive care resources, resulting in limited medical care and death keywords: care; covid-19; guidelines; medical; patient cache: cord-281711-whr4pfx9.txt plain text: cord-281711-whr4pfx9.txt item: #95 of 177 id: cord-282571-ilf73g71 author: Ni, Wentao title: Role of angiotensin-converting enzyme 2 (ACE2) in COVID-19 date: 2020-07-13 words: 5443 flesch: 39 summary: Cloning and functional expression as a captopril-insensitive carboxypeptidase ACE2 links amino acid malnutrition to microbial ecology and intestinal inflammation Angiotensinconverting enzyme 2 is a functional receptor for the SARS coronavirus Cryo-EM structure of the 2019-nCoV spike in the prefusion conformation Cryo-EM structure of the SARS coronavirus spike glycoprotein in complex with its host cell receptor ACE2 Structure of SARS coronavirus spike receptor-binding domain complexed with receptor Trilogy of ACE2: a peptidase in the renin-angiotensin system, a SARS receptor, and a partner for amino acid transporters Ectodomain shedding of angiotensin converting enzyme 2 in human airway epithelia TMPRSS2 and ADAM17 cleave ACE2 differentially and only proteolysis by TMPRSS2 augments entry driven by the severe acute respiratory syndrome coronavirus spike protein SARS-CoV-2 cell entry depends on ACE2 and TMPRSS2 and is blocked by a clinically proven protease inhibitor Structure, function, and evolution of coronavirus spike proteins Surface vimentin is critical for the cell entry of SARS-CoV Clathrindependent entry of severe acute respiratory syndrome coronavirus into target cells expressing ACE2 with the cytoplasmic tail deleted Tissue distribution of ACE2 protein, the functional receptor for SARS coronavirus. ACE2 is associated with multi-organ injury in COVID-19 Autopsies of SARS patients showed that SARS-CoV infection can cause injury to multiple organs, such as the heart, kidney, liver, skeletal muscle, central nervous system, and adrenal and thyroid glands, besides the lungs keywords: ace2; acute; angiotensin; cells; coronavirus; cov-2; covid-19; injury; patients; receptor; sars cache: cord-282571-ilf73g71.txt plain text: cord-282571-ilf73g71.txt item: #96 of 177 id: cord-284355-yb2t5ypa author: Xing, Changyang title: Lung ultrasound findings in patients with COVID-19 pneumonia date: 2020-04-28 words: 1171 flesch: 52 summary: key: cord-284355-yb2t5ypa authors: Xing, Changyang; Li, Qiaoying; Du, Hong; Kang, Wenzhen; Lian, Jianqi; Yuan, Lijun title: Lung ultrasound findings in patients with COVID-19 pneumonia date: 2020-04-28 journal: Crit Care DOI: 10.1186/s13054-020-02876-9 sha: doc_id: 284355 cord_uid: yb2t5ypa nan Since December 2019, the outbreak of pneumonia caused by a new coronavirus Lung ultrasound is an important tool for the diagnosis and follow-up of pneumonia in neonates, children, and adults [2] [3] [4] . keywords: area; lung; ultrasound cache: cord-284355-yb2t5ypa.txt plain text: cord-284355-yb2t5ypa.txt item: #97 of 177 id: cord-286771-77hs34jm author: Cruces, Pablo title: A physiological approach to understand the role of respiratory effort in the progression of lung injury in SARS-CoV-2 infection date: 2020-08-10 words: 5936 flesch: 35 summary: We showed preliminary experimental data that regional lung strain and heterogeneity can be identified in acutely injured lungs under unassisted spontaneous breathing. The role of three-dimensionality and alveolar pressure in the distribution and amplification of alveolar stresses Does regional lung strain correlate with regional inflammation in acute respiratory distress syndrome during nonprotective ventilation? keywords: acute; ards; breathing; covid-19; failure; injury; lung; patients; regional; sili; strain; ventilation cache: cord-286771-77hs34jm.txt plain text: cord-286771-77hs34jm.txt item: #98 of 177 id: cord-286963-rsmgx2xr author: Choi, Yoon Hee title: Renal replacement therapy is independently associated with a lower risk of death in patients with severe acute kidney injury treated with targeted temperature management after out-of-hospital cardiac arrest date: 2020-03-23 words: 4090 flesch: 48 summary: The distributions of CPC (1-5) at 6 months for the non-RRT vs. RRT groups were 3/108 (2.8%) vs. 12 Until recently, there was limited evidence on the use of RRT in OHCA patients. The most common treatment modality among RRT patients was continuous renal replacement therapy (111 [96.5%]), followed by intermittent haemodialysis (4 [3.5%]). keywords: aki; arrest; group; mortality; ohca; patients; rrt; stage cache: cord-286963-rsmgx2xr.txt plain text: cord-286963-rsmgx2xr.txt item: #99 of 177 id: cord-287333-h89tmi0w author: Sanfilippo, Filippo title: The importance of a “socially responsible” approach during COVID-19: the invisible heroes of science in Italy date: 2020-05-26 words: 571 flesch: 36 summary: In summary, Italian ICU physicians avoided compulsory public notoriety, behaving as invisible heroes of science. Ironically, ICU physicians commented we desperately need football games back, so that millions of people become again football managers rather than COVID-19 experts! keywords: covid-19; icu cache: cord-287333-h89tmi0w.txt plain text: cord-287333-h89tmi0w.txt item: #100 of 177 id: cord-287490-g1r9zew2 author: Despres, Cyrielle title: Prone positioning combined with high-flow nasal or conventional oxygen therapy in severe Covid-19 patients date: 2020-05-26 words: 875 flesch: 48 summary: key: cord-287490-g1r9zew2 authors: Despres, Cyrielle; Brunin, Yannick; Berthier, Francis; Pili-Floury, Sebastien; Besch, Guillaume title: Prone positioning combined with high-flow nasal or conventional oxygen therapy in severe Covid-19 patients date: 2020-05-26 journal: Crit Care DOI: 10.1186/s13054-020-03001-6 sha: doc_id: 287490 cord_uid: g1r9zew2 nan Prone positioning combined with high-flow nasal or conventional oxygen therapy in severe Covid-19 patients Cyrielle Despres 1 , Yannick Brunin 1 , Francis Berthier 1 , Sebastien Pili-Floury 1,2 and Guillaume Besch 1,2* Dear Editor, A massive outbreak of coronavirus disease 2019 (Covid-19) occurred in France in March and April 2020. Considering these observations, PP combined with either HFNO or COT could be proposed in spontaneously breathing, severe Covid-19 patients to avoid intubation. keywords: covid-19; patients cache: cord-287490-g1r9zew2.txt plain text: cord-287490-g1r9zew2.txt item: #101 of 177 id: cord-288284-fghu8ouc author: Hawryluck, Laura title: Clinical review: SARS – lessons in disaster management date: 2005-01-13 words: 4270 flesch: 42 summary: Some refused to care for SARS patients, and some refused to even enter wards containing SARS patients [22] . Although the designation of outbreak hospitals does place a greater toll on front-line workers in these institutions, those health care providers caring for greater numbers of SARS patients in Toronto actually experienced less anxiety in the form of post-traumatic stress disorder symptomatology [29] . keywords: care; critical; disaster; health; management; outbreak; patients; sars cache: cord-288284-fghu8ouc.txt plain text: cord-288284-fghu8ouc.txt item: #102 of 177 id: cord-290392-kpjp0sx4 author: Li, Xu title: Acute respiratory failure in COVID-19: is it “typical” ARDS? date: 2020-05-06 words: 2579 flesch: 45 summary: Since severe COVID-19 patients may deteriorate rapidly, patients receiving HFNO should be closely monitored and cared for by experienced personnel capable of endotracheal intubation at any time. It was possible that due to less damage to the endothelial cells, other organ functions were less involved in COVID-19 patients. keywords: ards; coronavirus; covid-19; patients; treatment cache: cord-290392-kpjp0sx4.txt plain text: cord-290392-kpjp0sx4.txt item: #103 of 177 id: cord-290741-y3lvewlz author: Zeng, Yingchun title: Prognosis when using extracorporeal membrane oxygenation (ECMO) for critically ill COVID-19 patients in China: a retrospective case series date: 2020-04-15 words: 849 flesch: 47 summary: Therefore, a further, larger sample size study and a comprehensive analysis of the medical value of using ECMO on COVID-19 patients are urgently required. [6] Worldwide data on prognosis when using ECMO to treat critically ill patients with COVID-19 infection are not available, and whether ECMO plays a role in reducing patient mortality rates is currently unknown. keywords: covid-19; ecmo; patients cache: cord-290741-y3lvewlz.txt plain text: cord-290741-y3lvewlz.txt item: #104 of 177 id: cord-290776-l6ajq6vp author: Frithiof, Robert title: Presence of SARS-CoV-2 in urine is rare and not associated with acute kidney injury in critically ill COVID-19 patients date: 2020-09-29 words: 993 flesch: 51 summary: Finally, the low concentration of viral RNA in a limited number of patients prevents definitive conclusions regarding mechanisms of viral urinary secretion. Nucleic acid was extracted from urine samples using NucliSENS® eMAG® (bioMerieux), and the amount of viral RNA was quantitated by detection of SARS-CoV-2 E and N-genes using real-time RT-PCR according to previously described protocols keywords: patients; sars; urine cache: cord-290776-l6ajq6vp.txt plain text: cord-290776-l6ajq6vp.txt item: #105 of 177 id: cord-291934-pm3ns6ge author: Jiang, Ronglin title: Chinese herbal experience for the 2019 novel coronavirus date: 2020-07-21 words: 409 flesch: 46 summary: Despite with limited sample size, the mortality rate decreased significantly after applying Chinese herbal to these patients (4/9 vs. 5/5 vs. 14/16, p = 0.033), especially in patients who received Chinese herbal therapy during the whole disease course. However, in China, Chinese herbal therapy has been fully applied to patients with COVID-19 infection in the middle stage of this epidemic and the effect is positive. keywords: patients cache: cord-291934-pm3ns6ge.txt plain text: cord-291934-pm3ns6ge.txt item: #106 of 177 id: cord-291955-mlju5f9u author: Haas, Lenneke E. M. title: Should we deny ICU admission to the elderly? Ethical considerations in times of COVID-19 date: 2020-06-09 words: 1209 flesch: 54 summary: The carefully balancing of pros and cons of ICU treatment should be done before ICU admission (as Advance Care Planning) but also during a (prolonged) ICU admission. As a consequence, a scenario can arise in which not every patient who needs ICU treatment can be admitted, and difficult decisions about allocation of ICU beds need to be made [2] [3] [4] . keywords: age; icu; patients cache: cord-291955-mlju5f9u.txt plain text: cord-291955-mlju5f9u.txt item: #107 of 177 id: cord-292335-al6v3b9x author: Crotty, Matthew P. title: Impact of antibacterials on subsequent resistance and clinical outcomes in adult patients with viral pneumonia: an opportunity for stewardship date: 2015-11-18 words: 4446 flesch: 29 summary: Pandemic 2009 influenza A in Argentina: a study of 337 patients on mechanical ventilation Predominant role of bacterial pneumonia as a cause of death in pandemic influenza: implications for pandemic influenza preparedness Critically ill infants and children with influenza A (H1N1) in pediatric intensive care units in Argentina Critically ill patients with 2009 influenza A (H1N1) infection in Canada Community acquired respiratory coinfection in critically ill patients with pandemic 2009 influenza A (H1N1) virus Critical illness from 2009 pandemic influenza A virus and bacterial coinfection in the United States Critical care services and 2009 H1N1 influenza in Australia and New Zealand Bacterial coinfections in lung tissue specimens from fatal cases of 2009 pandemic influenza A (H1N1)-United States Pulmonary pathologic findings of fatal 2009 pandemic influenza A/H1N1 viral infections Lung pathology in fatal novel human influenza A (H1N1)infection Epidemiology and clinical characteristics of community-acquired pneumonia in hospitalized children Viral etiology of severe pneumonia among Kenyan infants and children Incidence of respiratory pathogens in persons hospitalized with pneumonia in two provinces in Thailand A preliminary study of pneumonia etiology among hospitalized children in Kenya Etiology of community-acquired pneumonia in hospitalized children in northern Taiwan Viral coinfections in children with invasive pneumococcal disease Temporal association between rhinovirus circulation in the community and invasive pneumococcal disease in children Clinical and molecular characterization of rhinoviruses A, B, and C in adult patients with pneumonia Infection with human metapneumovirus predisposes mice to severe pneumococcal pneumonia Viral enhancement of nasal colonization with Haemophilus influenzae type b in the infant rat Epidemiology and predictors of multidrug-resistant community-acquired and health care-associated pneumonia Pneumonia pathogen characterization is an independent determinant of hospital readmission Cost-effectiveness of rapid diagnosis of viral respiratory tract infections in pediatric patients The effect of rapid respiratory viral diagnostic testing on antibiotic use in a children's hospital Clinical and financial benefits of rapid detection of respiratory viruses: an outcomes study Impact of rapid detection of viral and atypical bacterial pathogens by real-time polymerase chain reaction for patients with lower respiratory tract infection Antibiotic-resistant bugs in the 21st century: a clinical super-challenge A comparison of culture-positive and culture-negative health-care-associated pneumonia Epidemiological differences between sepsis syndrome with bacteremia and culture-negative sepsis Multidrug-resistant, extensively drug-resistant and pandrug-resistant bacteria: an international expert proposal for interim standard definitions for acquired resistance A new method of classifying prognostic comorbidity in longitudinal studies: development and validation Measurement of adult antibacterial drug use in 130 US hospitals: comparison of defined daily dose and days of therapy Infectious Diseases Society of America/American Thoracic Society consensus guidelines on the management of community-acquired pneumonia in adults Strategies to prevent antimicrobial resistance in the intensive care unit Burden of Clostridium difficile infection in the United States Clostridium difficile infection The use of antimicrobial agents after diagnosis of viral respiratory tract infections in hospitalized adults: antibiotics or anxiolytics The effect of vancomycin and third-generation cephalosporins on prevalence of vancomycin-resistant enterococci in 126 U.S. adult intensive care units The problem with cephalosporins Does antibiotic exposure increase the risk of methicillin-resistant Staphylococcus aureus (MRSA) isolation? key: cord-292335-al6v3b9x authors: Crotty, Matthew P.; Meyers, Shelby; Hampton, Nicholas; Bledsoe, Stephanie; Ritchie, David J.; Buller, Richard S.; Storch, Gregory A.; Kollef, Marin H.; Micek, Scott T. title: Impact of antibacterials on subsequent resistance and clinical outcomes in adult patients with viral pneumonia: an opportunity for stewardship date: 2015-11-18 journal: Crit Care DOI: 10.1186/s13054-015-1120-5 sha: doc_id: 292335 cord_uid: al6v3b9x INTRODUCTION: keywords: antibacterials; course; days; infection; patients; pneumonia; study; therapy; virus cache: cord-292335-al6v3b9x.txt plain text: cord-292335-al6v3b9x.txt item: #108 of 177 id: cord-293167-3bd3adip author: Nepal, Gaurav title: Neurological manifestations of COVID-19: a systematic review date: 2020-07-13 words: 5554 flesch: 43 summary: Acute respiratory distress syndrome, acute heart injury or failure, acute kidney injury, sepsis, disseminated intravascular coagulation, and lifethreatening metabolic derangements have all been reported in COVID-19 patients, particularly among those with underlying comorbidities or advanced age In this systematic review, we evaluate various neurological manifestations reported in COVID-19 patients and hypothesize their underlying pathophysiology. keywords: acute; case; china; coronavirus; cov-2; covid-19; infection; manifestations; patients; sars; studies; study; symptoms cache: cord-293167-3bd3adip.txt plain text: cord-293167-3bd3adip.txt item: #109 of 177 id: cord-293690-pxiv0m7n author: Scala, Raffaele title: Italian pulmonologist units and COVID-19 outbreak: “mind the gap”! date: 2020-06-29 words: 640 flesch: 43 summary: key: cord-293690-pxiv0m7n authors: Scala, Raffaele; Renda, Teresa; Corrado, Antonio; Vaghi, Adriano title: Italian pulmonologist units and COVID-19 outbreak: “mind the gap”! date: 2020-06-29 journal: Crit Care DOI: 10.1186/s13054-020-03087-y sha: doc_id: 293690 cord_uid: pxiv0m7n nan Raffaele Scala 1* , Teresa Renda 2 , Antonio Corrado 3 The outbreak of COVID-19 in Italy has shown the inadequacy of the health system to counterbalance a massive request for ICU care keywords: covid-19; patients cache: cord-293690-pxiv0m7n.txt plain text: cord-293690-pxiv0m7n.txt item: #110 of 177 id: cord-293766-vpfda3pd author: Ji, Jingjing title: Glucocorticoid therapy does not delay viral clearance in COVID-19 patients date: 2020-09-21 words: 741 flesch: 56 summary: The use of antiinflammatory drugs in the treatment of people with severe coronavirus disease 2019 (COVID-19): the perspectives of clinical immunologists from China Low-dose corticosteroid therapy does not delay viral clearance in patients with COVID-19 Persistence and clearance of viral RNA in 2019 novel coronavirus disease rehabilitation patients National Health Commission of the People's Republic of China. key: cord-293766-vpfda3pd authors: Ji, Jingjing; Zhang, Jinxia; Shao, Ziyun; Xie, Qifeng; Zhong, Li; Liu, Zhifeng title: Glucocorticoid therapy does not delay viral clearance in COVID-19 patients date: 2020-09-21 journal: Crit Care DOI: 10.1186/s13054-020-03287-6 sha: doc_id: 293766 cord_uid: vpfda3pd nan lower respiratory tract samples from confirmed patients were collected and tested by RT-PCR every 2 to 3 days. keywords: clearance; days; patients cache: cord-293766-vpfda3pd.txt plain text: cord-293766-vpfda3pd.txt item: #111 of 177 id: cord-295585-dl29curs author: Hékimian, Guillaume title: Severe pulmonary embolism in COVID-19 patients: a call for increased awareness date: 2020-06-02 words: 907 flesch: 40 summary: We retrospectively reviewed characteristics of patients with confirmed SARS-CoV-2 infection and acute PE who were admitted to our tertiary ICU, which serves as an ECMO referral center for the Greater Paris. key: cord-295585-dl29curs authors: Hékimian, Guillaume; Lebreton, Guillaume; Bréchot, Nicolas; Luyt, Charles-Edouard; Schmidt, Matthieu; Combes, Alain title: Severe pulmonary embolism in COVID-19 patients: a call for increased awareness date: 2020-06-02 journal: Crit Care DOI: 10.1186/s13054-020-02931-5 sha: doc_id: 295585 cord_uid: dl29curs nan Coronavirus disease 2019 (COVID-19) is associated with severe systemic inflammation and important elevation of fibrinogen and D-dimers that has been associated with a poor prognosis [1, 2] . keywords: ecmo; patients cache: cord-295585-dl29curs.txt plain text: cord-295585-dl29curs.txt item: #112 of 177 id: cord-297062-dmiplvt2 author: Almekhlafi, Ghaleb A. title: Presentation and outcome of Middle East respiratory syndrome in Saudi intensive care unit patients date: 2016-05-07 words: 4410 flesch: 45 summary: Epidemiological, demographic, and clinical characteristics of 47 cases of Middle East respiratory syndrome coronavirus disease from Saudi Arabia: a descriptive study Clinical aspects and outcomes of 70 patients with Middle East respiratory syndrome coronavirus infection: a single-center experience in Saudi Arabia Hospital-associated outbreak of Middle East respiratory syndrome coronavirus: a serologic, epidemiologic, and clinical description Middle Eastern respiratory syndrome corona virus (MERS CoV): case reports from a tertiary care hospital in Saudi Arabia IFN-alpha2a or IFN-beta1a in combination with ribavirin to treat Middle East respiratory syndrome coronavirus pneumonia: a retrospective study Middle East respiratory syndrome coronavirus: a case-control study of hospitalized patients Characteristics and outcomes of Middle East respiratory syndrome coronavirus patients admitted to an intensive care unit in Jeddah, Saudi Arabia Clinical course and outcomes of critically ill patients with Middle East respiratory syndrome coronavirus infection Acute management and long-term survival among subjects with severe Middle East respiratory syndrome coronavirus pneumonia and ARDS APACHE II: a severity of disease classification system The SOFA (Sepsis-related Organ Failure Assessment) score to describe organ dysfunction/failure. Interestingly, Acinetobacter baumannii, which is an emerging fatal infection in ICU patients worldwide, was isolated from deep tracheal aspirates in one in four patients. keywords: admission; coronavirus; cov; east; icu; infection; mers; middle; patients; syndrome cache: cord-297062-dmiplvt2.txt plain text: cord-297062-dmiplvt2.txt item: #113 of 177 id: cord-297863-ou432md0 author: Ye, Lei title: Infection prevention and control in nursing severe coronavirus disease (COVID-19) patients during the pandemic date: 2020-06-12 words: 1001 flesch: 44 summary: Clinical course and outcomes of critically ill patients with SARS-CoV-2 pneumonia in Wuhan, China: a single-centered, retrospective, observational study Clinical characteristics of 138 hospitalized patients with 2019 novel coronavirus-infected pneumonia in Wuhan Coronavirus Disease 2019 (COVID-19) in Italy COVID-19) in Italy: Analysis of Risk Factors and Proposed Remedial Measures Characteristics and Outcomes of 21 Critically Ill Patients With COVID-19 in Washington State Tribute to health workers in China: a group of respectable population during the outbreak of the COVID-19 Characteristics of health vare personnel with COVID-19 -United States Infection prevention and control during health care when COVID-19 is suspected: interim guidance Publisher's Note Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations Not applicable. key: cord-297863-ou432md0 authors: Ye, Lei; Yang, Shulan; Liu, Caixia title: Infection prevention and control in nursing severe coronavirus disease (COVID-19) patients during the pandemic date: 2020-06-12 journal: Crit Care DOI: 10.1186/s13054-020-03076-1 sha: doc_id: 297863 cord_uid: ou432md0 nan with COVID-19 patients in health care, household, and community settings were all detected [7] . keywords: care; covid-19; health cache: cord-297863-ou432md0.txt plain text: cord-297863-ou432md0.txt item: #114 of 177 id: cord-299650-lhphdjeu author: Whittle, John title: Persistent hypermetabolism and longitudinal energy expenditure in critically ill patients with COVID-19 date: 2020-09-28 words: 1159 flesch: 38 summary: Further, understanding the energy expenditure of COVID-19 ICU patients is essential to help determine safe, optimal nutrition needs for the ICU provider [3] , as both over-/underfeeding is associated with increased ICU mortality Longitudinal IC data presented here demonstrate a progressive hypermetabolic phenotype beginning 1 week post-intubation in COVID-19 ICU patients, with significantly greater mREE versus predictive equations or ASPEN-recommended 11-14 kcal/kg ABW for obese subjects used currently to determine energy requirements. keywords: covid-19; data; icu; mree; patients cache: cord-299650-lhphdjeu.txt plain text: cord-299650-lhphdjeu.txt item: #115 of 177 id: cord-300135-iwvkvs3k author: Lemay, Francois title: Description of an alternative method for optimal and comfortable two-handed face mask ventilation: the transverse mandibular technique date: 2020-05-26 words: 616 flesch: 55 summary: Whatever the primary FMV technique, tiring practitioners might want to alternate or combine techniques. In other techniques, lateral pressure must be used with the thumbs, which can be difficult especially in smaller hands. keywords: fmv; technique cache: cord-300135-iwvkvs3k.txt plain text: cord-300135-iwvkvs3k.txt item: #116 of 177 id: cord-300510-fhpkdqr0 author: Mojoli, Francesco title: Our recommendations for acute management of COVID-19 date: 2020-05-08 words: 1085 flesch: 32 summary: Rapid response to COVID-19 outbreak in Northern Italy: how to convert a classic infectious disease ward into a COVID-19 response centre Effect of noninvasive ventilation delivered by helmet vs face mask on the rate of endotracheal intubation in patients with acute respiratory distress syndrome: a randomized clinical trial Critical care management of adults with community-acquired severe respiratory viral infection Clinical management of severe acute respiratory infection when Novel coronavirus (2019-nCoV) infection is suspected: Interim Guidance 28 Esophageal and transpulmonary pressure in the clinical setting: meaning, usefulness and perspectives Lung ultrasound for critically ill patients Assessment of lung aeration and recruitment by CT scan and ultrasound in acute respiratory distress syndrome patients Lung ultrasound for early diagnosis of ventilator-associated pneumonia Risk factors associated with acute respiratory distress syndrome and death in patients with coronavirus disease 2019 pneumonia in Wuhan, China Thrombotic events in SARS-Cov 2 patients: an urgent call for ultrasound screening Setup of a dedicated coronavirus intensive care unit: logistical aspects Publisher's Note Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations 7. Perform early intubation if poor response to continuous positive airway pressure in terms of oxygenation: do not trust patients' relatively good respiratory mechanics and feeling of improved dyspnoea, since these patients may have relatively normal lung compliance and the only clinical sign of fatigue may be high respiratory rate. keywords: care; coronavirus; lung; patients; pressure cache: cord-300510-fhpkdqr0.txt plain text: cord-300510-fhpkdqr0.txt item: #117 of 177 id: cord-300897-lih5f6cj author: Du, Bin title: Clinical review: Critical care medicine in mainland China date: 2010-02-25 words: 2765 flesch: 45 summary: key: cord-300897-lih5f6cj authors: Du, Bin; Xi, Xiuming; Chen, Dechang; Peng, Jinmin title: Clinical review: Critical care medicine in mainland China date: 2010-02-25 journal: Crit Care DOI: 10.1186/cc8222 sha: doc_id: 300897 cord_uid: lih5f6cj Critical care medicine began in mainland China in the early 1980s. Although advanced life support techniques, especially positive pressure ventilation, inspired the development of critical care medicine in Europe and North America in the 1950s, critical care medicine is still one of the newest disciplines of clinical medicine in mainland China. keywords: care; china; critical; icu; mainland; medicine cache: cord-300897-lih5f6cj.txt plain text: cord-300897-lih5f6cj.txt item: #118 of 177 id: cord-303577-2gxo5mft author: Flaczyk, Adam title: Comparison of published guidelines for management of coagulopathy and thrombosis in critically ill patients with COVID 19: implications for clinical practice and future investigations date: 2020-09-16 words: 5714 flesch: 26 summary: The CDC mentions that standard regimens for patients without COVID-19 patients should be used. Pulmonary embolism in a young pregnant woman with COVID-19 Coagulopathy and antiphospholipid antibodies in patients with covid-19 COVID and coagulation: bleeding and thrombotic manifestations of SARS-CoV2 infection COVID-19) treatment guidelines ISTH interim guidance on recognition and management of coagulopathy in COVID-19 COVID-19 and VTE/anticoagulation: frequently asked questions COVID-19 and coagulopathy: frequently asked questions Prevention, diagnosis and treatment of venous thromboembolism in patients with COVID-19: CHEST Guideline and Expert Panel Report Scientific and Standardization Committee communication: clinical guidance on the diagnosis, prevention and treatment of venous thromboembolism in hospitalized patients with COVID-19 Thromboembolism and anticoagulant therapy during the COVID-19 pandemic: interim clinical guidance from the anticoagulation forum COVID-19 and thrombotic or thromboembolic disease: keywords: acf; anticoagulation; bleeding; covid-19; isth; mentions; patients; risk cache: cord-303577-2gxo5mft.txt plain text: cord-303577-2gxo5mft.txt item: #119 of 177 id: cord-303893-47lxq8pi author: Jalkanen, Juho title: Interferon beta-1a for COVID-19: critical importance of the administration route date: 2020-06-12 words: 1277 flesch: 41 summary: Severely ill COVID-19 patients with increased levels of plasma cytokines (especially IL-6) show signs of immune exhaustion and poor IFN responses [13] . Prior corner stone PK studies investigating s.c. vs. i.v. administration of IFN-beta-1a conclude that s.c. administration produces significantly lower drug concentrations and incomplete bioavailability compared to i.v. dosing. keywords: beta; i.v; ifn; s.c cache: cord-303893-47lxq8pi.txt plain text: cord-303893-47lxq8pi.txt item: #120 of 177 id: cord-304070-jw1lxwyd author: Lapinsky, Stephen E title: Prospective evaluation of an internet-linked handheld computer critical care knowledge access system date: 2004-10-14 words: 3229 flesch: 40 summary: Handheld information access alone is unlikely to change clinical practice, but it should be considered a component of an electronic knowledge translation system. Because of their portability, handheld devices may be more practical tools for disseminating knowledge to the point of care. keywords: access; care; handheld; information; physicians; scenarios; study; system cache: cord-304070-jw1lxwyd.txt plain text: cord-304070-jw1lxwyd.txt item: #121 of 177 id: cord-304327-mtkgr542 author: Jouffroy, Romain title: Prehospital pulse oximetry: a red flag for early detection of silent hypoxemia in COVID-19 patients date: 2020-06-08 words: 651 flesch: 45 summary: In summary, this retrospective study based on prehospital first responder data highlighted a relatively higher discrepancy between SpO2i and RRi in COVID-19 ARF patients, in comparison with previous non-COVID-19 ARF patients. After having measured the SpO2i/RRi values in COVID-19 patients, we compared them to those of non-COVID-19 patients (i.e., patients with other causes of ARF treated by the BLS teams over the previous 3 years in the same period). keywords: covid-19; patients cache: cord-304327-mtkgr542.txt plain text: cord-304327-mtkgr542.txt item: #122 of 177 id: cord-304746-7yzybukk author: Li, Xinye title: Cardiac injury associated with severe disease or ICU admission and death in hospitalized patients with COVID-19: a meta-analysis and systematic review date: 2020-07-28 words: 4590 flesch: 42 summary: CONCLUSIONS: COVID-19 patients with elevated TnI levels are at significantly higher risk of severe disease, ICU admission, and death. [Image: see text] Conclusions: COVID-19 patients with elevated TnI levels are at significantly higher risk of severe disease, ICU admission, and death. keywords: cardiac; covid-19; disease; icu; icu admission; levels; non; patients cache: cord-304746-7yzybukk.txt plain text: cord-304746-7yzybukk.txt item: #123 of 177 id: cord-305946-ytabywxd author: Zhu, Shiping title: Predictive value of neutrophil to lymphocyte and platelet to lymphocyte ratio in COVID-19 date: 2020-08-28 words: 489 flesch: 30 summary: First, uncontrolled inflammatory response plays a vital role in COVID-19 disease, and both NLR and platelet to lymphocyte ratio (PLR) have been recognized as inflammatory factors in various lung diseases [2, 3] , such as lung cancer and obstructive lung disease. 305946 cord_uid: ytabywxd nan Predictive value of neutrophil to lymphocyte and platelet to lymphocyte ratio in COVID-19 Shiping Zhu 1 , Lei Dong 2 and Wanru Cai 2* Keywords: Neutrophil to leucocyte ratio, Platelet to lymphocyte ratio, To the Editor, In a recent study, Dr. Ma [1] investigated the neutrophil to lymphocyte ratio (NLR) in predicting moderate-severe acute respiratory distress syndrome (ARDS) in patients with COVID-19 infection. keywords: lymphocyte cache: cord-305946-ytabywxd.txt plain text: cord-305946-ytabywxd.txt item: #124 of 177 id: cord-307512-70j4vn78 author: Worku, Elliott title: Provision of ECPR during COVID-19: evidence, equity, and ethical dilemmas date: 2020-07-27 words: 3968 flesch: 29 summary: Hypoxaemic respiratory failure leading to cardiac arrest appears to be common in COVID-19 patients. The most appropriate argument for withholding or withdrawing CCPR and ECPR in COVID-19 patients must be non-maleficence to the patient and others. keywords: arrest; cannulation; cardiac; covid-19; ecpr; hospital; pandemic; patients; resuscitation; support cache: cord-307512-70j4vn78.txt plain text: cord-307512-70j4vn78.txt item: #125 of 177 id: cord-307592-hyeshh63 author: Kong, Yaxian title: VEGF-D: a novel biomarker for detection of COVID-19 progression date: 2020-06-23 words: 692 flesch: 44 summary: A total of 24 COVID-19 patients were enrolled in this study, including 14 (58.3%) severe patients and 10 (41.7%) critical patients (Table 1 ). As expected, D-dimer, age, IL-6, and lymphocyte count associated with clinical outcomes of COVID-19 patients reported previously were also highly ranked. keywords: patients; vegf cache: cord-307592-hyeshh63.txt plain text: cord-307592-hyeshh63.txt item: #126 of 177 id: cord-310561-67kp743f author: Shah, Akshay title: Systemic hypoferremia and severity of hypoxemic respiratory failure in COVID-19 date: 2020-06-09 words: 972 flesch: 46 summary: Therefore, we sought to characterise iron parameters, including serum iron, in COVID-19 intensive care unit (ICU) patients and relate these to disease severity. Compared with patients with non-severe hypoxemia, patients with severe hypoxemia had significantly lower levels of serum iron (median 2.3 (IQR, 2.2-2.5) vs 4.3 (IQR, 3.3-5.2) μmol/L, p < 0.001) and lymphocyte counts (mean (SD) 0.50 (0.2) vs. 0.87 (0.4), p = 0.0152). keywords: covid-19; iron; patients; serum cache: cord-310561-67kp743f.txt plain text: cord-310561-67kp743f.txt item: #127 of 177 id: cord-310776-4iqu18gi author: Supady, Alexander title: Extracorporeal cytokine adsorption as an alternative to pharmacological inhibition of IL-6 in COVID-19 date: 2020-08-20 words: 546 flesch: 22 summary: key: cord-310776-4iqu18gi authors: Supady, Alexander; Duerschmied, Daniel; Bode, Christoph; Rieder, Marina; Lother, Achim title: Extracorporeal cytokine adsorption as an alternative to pharmacological inhibition of IL-6 in COVID-19 date: 2020-08-20 journal: Crit Care DOI: 10.1186/s13054-020-03238-1 sha: doc_id: 310776 cord_uid: 4iqu18gi nan Extracorporeal cytokine adsorption as an alternative to pharmacological inhibition of IL-6 in COVID-19 Alexander Supady 1,2,3* , Daniel Duerschmied 1,2 , Christoph Bode 1,2 , Marina Rieder 1,2 and Achim Lother 1, 2, 4 With great interest we read the article by Convertino et Following initial reports describing Interleukin-6 (IL-6) as a predictive factor for a negative outcome, extracorporeal cytokine adsorption was discussed as a possible treatment option for severe COVID-19 cases. keywords: covid-19; cytokine cache: cord-310776-4iqu18gi.txt plain text: cord-310776-4iqu18gi.txt item: #128 of 177 id: cord-310997-ulgemn42 author: Swai, Joel title: Letter to the editor—Mortality rate of acute kidney injury in SARS, MERS, and COVID-19 infection: a systematic review and meta-analysis date: 2020-09-11 words: 789 flesch: 52 summary: [6] , future large meta-analyses may be suggested to explore the clinical impacts from different races in AKI mortality in COVID-19 patients. key: cord-310997-ulgemn42 authors: Swai, Joel title: Letter to the editor—Mortality rate of acute kidney injury in SARS, MERS, and COVID-19 infection: a systematic review and meta-analysis date: 2020-09-11 journal: Crit Care DOI: 10.1186/s13054-020-03239-0 sha: doc_id: 310997 cord_uid: ulgemn42 nan Letter to the editor-Mortality rate of acute kidney injury in SARS, MERS, and COVID-19 infection: a systematic review and metaanalysis Joel Swai * keywords: covid-19; mortality cache: cord-310997-ulgemn42.txt plain text: cord-310997-ulgemn42.txt item: #129 of 177 id: cord-312484-epbhdx55 author: Wang, Hongliang title: COVID-19 infection epidemic: the medical management strategies in Heilongjiang Province, China date: 2020-03-18 words: 983 flesch: 43 summary: They also supervised the procedures of medical staffs in the isolation wards by wireless communication equipment. Medical staffs in Heilongjiang province were divided into 4 groups (Fig. 1 ). keywords: covid-19; patients; staffs cache: cord-312484-epbhdx55.txt plain text: cord-312484-epbhdx55.txt item: #130 of 177 id: cord-313914-m09lw0i4 author: Li, Chenglong title: Extracorporeal membrane oxygenation programs for COVID-19 in China date: 2020-06-08 words: 836 flesch: 44 summary: The Chinese Society of Extracorporeal Life Support (CSECLS) performed a survey of ECMO programs for COVID-19 in China, aimed at investigating the program organization and the potential factors associated with outcomes during the pandemic. Compared with ECMO programs in Hubei, more programs outside Hubei initiated ECMO in older patients (36.7% vs 3.3% in age ≥ 75, p = 0.001; 55.1% vs 26.7% in age 65-74, p = 0.014). keywords: covid-19; ecmo; programs cache: cord-313914-m09lw0i4.txt plain text: cord-313914-m09lw0i4.txt item: #131 of 177 id: cord-314310-g1zmggf4 author: Honore, Patrick M. title: TPE seems to be a treatment that may improve outcomes by effectively removing fibrin degradation products and restoring coagulation status: fact or fiction? date: 2020-10-06 words: 1078 flesch: 47 summary: After propensity score matching, the mortality rate, in the patients with D-dimer level ≥ 2 mg/L, was 8.3% in patients who received TPE (TPE +) versus 58.3% in those who did not (TPE −), with no thromboembolic events detected in either sub-group [1] . Low molecular weight heparin; TPE +: Patients who received TPE; TPE −: keywords: mortality; patients; tpe cache: cord-314310-g1zmggf4.txt plain text: cord-314310-g1zmggf4.txt item: #132 of 177 id: cord-314737-2fun90ze author: Cardoso, Filipe S. title: Age, sex, and comorbidities predict ICU admission or mortality in cases with SARS-CoV2 infection: a population-based cohort study date: 2020-07-28 words: 855 flesch: 39 summary: key: cord-314737-2fun90ze authors: Cardoso, Filipe S.; Papoila, Ana L.; Machado, Rita Sá; Fidalgo, Pedro title: Age, sex, and comorbidities predict ICU admission or mortality in cases with SARS-CoV2 infection: a population-based cohort study date: 2020-07-28 journal: Crit Care DOI: 10.1186/s13054-020-03173-1 sha: doc_id: 314737 cord_uid: 2fun90ze nan Previous studies have identified risk factors for severe acute respiratory syndrome coronavirus 2 (SARS-CoV2) severe outcomes preferentially among hospitalized patients; therefore, they may have understated the denominator of such estimations [1, 2] . Cases with ICU admission or nonsurvivors had higher median age (80 vs. 49 years; P < 0.001) and were more frequently men (54.7% vs. 40.8%; P < 0.001) than those that were not admitted to the ICU and survived. keywords: admission; cases; icu cache: cord-314737-2fun90ze.txt plain text: cord-314737-2fun90ze.txt item: #133 of 177 id: cord-314872-njlgggzq author: Kornilov, Sergey A. title: Plasma levels of soluble ACE2are associated with sex, Metabolic Syndrome, and its biomarkers in a large cohort, pointing to a possible mechanism for increased severity in COVID-19 date: 2020-07-22 words: 1366 flesch: 41 summary: Confirming results from recent studies [3, 4] , we found higher plasma sACE2 levels in men compared to women (P = 2 × 10 −16 ), and in older individuals (P = 8.6 × 10 −11 ), with the age association more pronounced in women (for the interaction, P int = 0.02). The associations of plasma sACE2 levels with sex, age, and metabolic syndrome (MetS). keywords: levels; plasma; sace2 cache: cord-314872-njlgggzq.txt plain text: cord-314872-njlgggzq.txt item: #134 of 177 id: cord-315685-ute3dxwu author: Ehaideb, Salleh N. title: Evidence of a wide gap between COVID-19 in humans and animal models: a systematic review date: 2020-10-06 words: 5553 flesch: 45 summary: key: cord-315685-ute3dxwu authors: Ehaideb, Salleh N.; Abdullah, Mashan L.; Abuyassin, Bisher; Bouchama, Abderrezak title: Evidence of a wide gap between COVID-19 in humans and animal models: a systematic review date: 2020-10-06 journal: Crit Care DOI: 10.1186/s13054-020-03304-8 sha: doc_id: 315685 cord_uid: ute3dxwu BACKGROUND: Animal models of COVID-19 have been rapidly reported after the start of the pandemic. Inclusion criteria were the establishment of animal models of COVID-19 as an endpoint. keywords: animal; cov-2; covid-19; human; lung; mice; models; response; sars; studies; virus cache: cord-315685-ute3dxwu.txt plain text: cord-315685-ute3dxwu.txt item: #135 of 177 id: cord-316829-wm6y6uwm author: Vargas, Maria title: Logistic and organizational aspects of a dedicated intensive care unit for COVID-19 patients date: 2020-05-18 words: 903 flesch: 50 summary: On 6 April, the worldwide ICU admission rate of COVID-19 patients was 3% ranging from 1% of total cases in Africa to 4% of total cases in Europe [4] . From 10 March, our ICU is completely dedicated to COVID-19 patients, and actually, it is one of the largest cohorted ICU in the south of Italy admitting 12 positive critically ill patients (Fig. 1 ). keywords: covid-19; icu; patients cache: cord-316829-wm6y6uwm.txt plain text: cord-316829-wm6y6uwm.txt item: #136 of 177 id: cord-317729-ruvx9zwd author: Wilson, Darius Cameron title: Adrenomedullin in COVID-19 induced endotheliitis date: 2020-07-09 words: 632 flesch: 21 summary: key: cord-317729-ruvx9zwd authors: Wilson, Darius Cameron; Schefold, Joerg C.; Baldirà, Jaume; Spinetti, Thibaud; Saeed, Kordo; Elke, Gunnar title: Adrenomedullin in COVID-19 induced endotheliitis date: 2020-07-09 journal: Crit Care DOI: 10.1186/s13054-020-03151-7 sha: doc_id: 317729 cord_uid: ruvx9zwd nan Darius Cameron Wilson 1* , Joerg C. Schefold 2 , Jaume Baldirà 3 , Thibaud Spinetti 2 , Kordo Saeed 4 and Gunnar Elke 5 Despite the exponential growth in research following the rapid spread of SARS-CoV-2 and subsequent COVID-19 pandemic, the underlying pathophysiological mechanisms in COVID-19 patients remain poorly understood. The assessment of MR-proADM in future COVID-19 studies may therefore provide important information into the pathophysiological mechanisms underlying endotheliitis and subsequent organ dysfunction. keywords: covid-19; patients cache: cord-317729-ruvx9zwd.txt plain text: cord-317729-ruvx9zwd.txt item: #137 of 177 id: cord-319101-2vdd10mu author: Abrams, Darryl title: ECMO during the COVID-19 pandemic: when is it unjustified? date: 2020-08-17 words: 1187 flesch: 40 summary: The inability to manage this strain will likely be greatest among lower-volume, less-experienced ECMO centers, providing rationale for the regionalization of ECMO [9] , an approach which itself may be further limited by excess patient volume at all centers, resulting in suboptimal provision of care to ECMO patients in general. As the pandemic resolves and patient volume decreases, there may be increasing resource availability and ECMO use (blue arrow) or decreasing demand (green arrow) keywords: covid-19; ecmo; patients cache: cord-319101-2vdd10mu.txt plain text: cord-319101-2vdd10mu.txt item: #138 of 177 id: cord-319936-5uze06rp author: Dixon, Barry title: A phase 1 trial of nebulised heparin in acute lung injury date: 2008-05-06 words: 3139 flesch: 48 summary: key: cord-319936-5uze06rp authors: Dixon, Barry; Santamaria, John D; Campbell, Duncan J title: A phase 1 trial of nebulised heparin in acute lung injury date: 2008-05-06 journal: Crit Care DOI: 10.1186/cc6894 sha: doc_id: 319936 cord_uid: 5uze06rp INTRODUCTION: Animal studies of acute lung injury (ALI) suggest nebulised heparin may limit damage from fibrin deposition in the alveolar space and microcirculation. keywords: ali; day; group; heparin; levels; lung cache: cord-319936-5uze06rp.txt plain text: cord-319936-5uze06rp.txt item: #139 of 177 id: cord-320637-jn8dh4vk author: Nosaka, Nobuyuki title: Anti-high mobility group box-1 monoclonal antibody treatment provides protection against influenza A virus (H1N1)-induced pneumonia in mice date: 2015-06-11 words: 4964 flesch: 41 summary: Here we provide compelling data demonstrating that anti-HMGB1 mAb may provide a novel and effective pharmacological therapeutic strategy for severe influenza virus infection by reducing the inflammatory responses induced by HMGB1. Administration of anti-HMGB1 mAb to H1N1-inoculated mice The mice were randomly assigned to two groups after virus inoculation, and an anti-HMGB1 mAb (#10-22, immunoglobulin G 2a subclass, 2 mg/kg) keywords: expression; group; h1n1; hmgb1; influenza; inoculation; lung; mab; mice; pneumonia; rage; virus cache: cord-320637-jn8dh4vk.txt plain text: cord-320637-jn8dh4vk.txt item: #140 of 177 id: cord-321440-sts3re6p author: Klein, Sebastian J. title: Unrecognized diabetes in critically ill COVID-19 patients date: 2020-07-09 words: 903 flesch: 46 summary: Recent data demonstrating viral particles in endothelial cells of several organs suggest endotheliitis as a possible mechanism of organ dysfunction leading to critical illness in COVID-19 patients which may be aggravated by endothelial Abbreviations: IQR interquartile range, BMI body mass index, HbA1c glycated hemoglobin, CRP C-reactive protein, IL-6 interleukin-6, COPD chronic obstructive pulmonary disease, SARS-CoV-2 severe acute respiratory syndrome coronavirus Patients were included in the analysis if they were 18 years of age or older, had confirmed COVID-19, and were admitted to an intensive care unit from March 11 to April 29, 2020. keywords: covid-19; diabetes; hba1c; patients cache: cord-321440-sts3re6p.txt plain text: cord-321440-sts3re6p.txt item: #141 of 177 id: cord-322726-obnil3b7 author: Nakamura, Kensuke title: Early rehabilitation with dedicated use of belt-type electrical muscle stimulation for severe COVID-19 patients date: 2020-06-15 words: 720 flesch: 39 summary: Automated EMS is expected to be an ideal mobilization for severe COVID-19 patients. 1 Belt-type electrical muscle stimulation for severe COVID-19 patients. keywords: covid-19; ems cache: cord-322726-obnil3b7.txt plain text: cord-322726-obnil3b7.txt item: #142 of 177 id: cord-323327-08p122lw author: van de Veerdonk, Frank L. title: Blocking IL-1 to prevent respiratory failure in COVID-19 date: 2020-07-18 words: 3023 flesch: 36 summary: Studies that recruited in total almost 2000 patients demonstrated that although anakinra did not reduce the overall all-cause mortality, survival was increased in the subgroup of sepsis patients with features of MAS (ferritin elevations in excess of 2000 ng/ml, coagulopathy, and liver enzyme elevations) Yearb Intensive Care Emerg Med Coagulation abnormalities and thrombosis in patients with COVID-19 Kallikrein-kinin blockade in patients with COVID-19 to prevent acute respiratory distress syndrome Endothelial cell infection and endotheliitis in COVID-19 Cytotoxic therapy for severe avian influenza A (H5N1) infection A case of macrophage activation syndrome successfully treated with anakinra Macrophage activation syndrome treated with anakinra Benefit of anakinra in treating pediatric secondary hemophagocytic lymphohistiocytosis Interleukin-1 receptor blockade is associated with reduced mortality in sepsis patients with features of macrophage activation syndrome: reanalysis of a prior phase III trial Confirmatory interleukin-1 receptor antagonist trial in severe sepsis: a phase III, randomized, double-blind, placebo-controlled, multicenter trial. keywords: anakinra; covid-19; il-1; mas; patients; sars; syndrome cache: cord-323327-08p122lw.txt plain text: cord-323327-08p122lw.txt item: #143 of 177 id: cord-323601-qzruawe1 author: Dufranc, Etienne title: IL6-R blocking with tocilizumab in critically ill patients with hemophagocytic syndrome date: 2020-04-22 words: 906 flesch: 37 summary: HLH 94 and 2004 protocols were developed for children with primary HLH (50% successes), but adult patients may be more at risk to develop chemotherapy toxicities Alternatives should thus be discussed in adult patients with chemotherapy-induced bone marrow failure, underlying autoimmune diseases requiring cytotoxic agents, or with a moderate form of HLH not related to hematological malignancies. keywords: hlh; patients; tocilizumab cache: cord-323601-qzruawe1.txt plain text: cord-323601-qzruawe1.txt item: #144 of 177 id: cord-324598-z65p60z9 author: He, Huaiwu title: Influence of overdistension/recruitment induced by high positive end-expiratory pressure on ventilation–perfusion matching assessed by electrical impedance tomography with saline bolus date: 2020-09-29 words: 4827 flesch: 48 summary: (VQMatch(%) at high PEEP minus that at ZEEP) was significantly correlated with recruited pixels (r = 0.468, P = 0.009), overdistended pixels (r = − 0.666, P < 0.001), O/R ratio (r = − 0.686, P < 0.001), and ΔSpO(2) (r = 0.440, P = 0.015). Patients in the low O/R ratio group (14/30) had significantly higher Shunt(%) and lower VQMatch(%) than those in the high O/R ratio group (16/30) at ZEEP but not at high PEEP. keywords: increase; lung; patients; peep; ratio; recruitment; ventilation cache: cord-324598-z65p60z9.txt plain text: cord-324598-z65p60z9.txt item: #145 of 177 id: cord-325626-r7k7u7ro author: Yu, Xia title: SARS-CoV-2 viral load in sputum correlates with risk of COVID-19 progression date: 2020-04-23 words: 797 flesch: 48 summary: Whether there is correlation between viral load and disease severity has not been clarified. Viral load is indicated by the Ct value of RT-PCR assay. keywords: load; patients cache: cord-325626-r7k7u7ro.txt plain text: cord-325626-r7k7u7ro.txt item: #146 of 177 id: cord-325664-9ool5z9s author: Immovilli, Paolo title: COVID-19 mortality and ICU admission: the Italian experience date: 2020-05-15 words: 376 flesch: 40 summary: These preliminary data evidence the pivotal preventive role played by early lockdown measures to reduce outbreak magnitude and place less pressure on ICU beds availability; however, these data should be interpreted with caution because of possible bias: patients could be allowed outside the ICU due to various reasons (i.e., age, comorbidities, frailty index), as it occurs in daily clinical practice. However, examining the differing outbreak magnitudes in regions with different ICU availability evidenced a discrepancy in the percentage of ICU-admitted patients. keywords: icu; mortality cache: cord-325664-9ool5z9s.txt plain text: cord-325664-9ool5z9s.txt item: #147 of 177 id: cord-325694-xx6m60hv author: Kneyber, Martin C. J. title: Paediatric and adult critical care medicine: joining forces against Covid-19 date: 2020-06-16 words: 586 flesch: 49 summary: An adult intensive care unit consultant reviewed patient plans twice a day to guarantee quality of adult critical care We thus decided to maintain our current PICU capacity and to re-open, for adult COVID-19 care, the part of our PICU that was closed due nursing staff shortage keywords: care; picu cache: cord-325694-xx6m60hv.txt plain text: cord-325694-xx6m60hv.txt item: #148 of 177 id: cord-326124-jtpsydy5 author: Adam, Elisabeth H. title: Fibrin-derived peptide Bβ15-42 (FX06) as salvage treatment in critically ill patients with COVID-19-associated acute respiratory distress syndrome date: 2020-09-24 words: 886 flesch: 41 summary: Norepinephrine dosages decreased initially after the initiation of FX06 therapy before returning to nearbaseline values after some days (data not shown). Mean oxygenation ratio improved over the first 3 days after the beginning of FX06 application, returned to baseline and increased steadily afterwards from day seven on (Fig. 1a) . keywords: fx06; patients; treatment cache: cord-326124-jtpsydy5.txt plain text: cord-326124-jtpsydy5.txt item: #149 of 177 id: cord-326315-ncfxlnpj author: Cillóniz, Catia title: Community-acquired polymicrobial pneumonia in the intensive care unit: aetiology and prognosis date: 2011-09-14 words: 4179 flesch: 26 summary: The clinical significance of polymicrobial aetiology in CAP patients admitted to the ICU has not been specifically addressed. The frequency and clinical significance of polymicrobial aetiology in community-acquired pneumonia (CAP) patients admitted to the ICU have been poorly studied. keywords: aetiology; cap; disease; hospital; patients; pneumonia; polymicrobial; treatment; viruses cache: cord-326315-ncfxlnpj.txt plain text: cord-326315-ncfxlnpj.txt item: #150 of 177 id: cord-326874-rdwvsm4s author: Wu, Chaomin title: Corticosteroid therapy for coronavirus disease 2019-related acute respiratory distress syndrome: a cohort study with propensity score analysis date: 2020-11-10 words: 4472 flesch: 31 summary: In this clinical practice setting, low-dose corticosteroid treatment was associated with reduced risk of in-hospital death within 60 days in COVID-19 patients who developed ARDS. [7] , and has been widely used by clinicians to suppression of hyperinflammation in COVID-19 patients, especially those with critical illness keywords: ards; corticosteroids; covid-19; days; hospital; patients; score; treatment cache: cord-326874-rdwvsm4s.txt plain text: cord-326874-rdwvsm4s.txt item: #151 of 177 id: cord-327622-ezgufe24 author: Kaur, Ramandeep title: Practical strategies to reduce nosocomial transmission to healthcare professionals providing respiratory care to patients with COVID-19 date: 2020-09-23 words: 6338 flesch: 37 summary: Influenza Other Respir Viruses Dynamics of infectious disease transmission by inhalable respiratory droplets Guidelines for preventing the transmission of Mycobacterium tuberculosis in health-care settings Survival of influenza viruses on environmental surfaces Aerosol and surface stability of SARS-CoV-2 as compared with SARS-CoV-1 High-flow nasal cannula for COVID-19 patients: low risk of bio-aerosol dispersion Dispersal of respiratory droplets with open vs closed oxygen delivery masks: implications for the transmission of severe acute respiratory syndrome Year in review 2019: high-flow nasal cannula (HFNC) oxygen therapy for adult patients High flow nasal cannula compared with conventional oxygen therapy for acute hypoxemic respiratory failure: a systematic review and meta-analysis Use of high flow nasal therapy to treat moderate to severe hypoxemic respiratory failure in Exhaled air dispersion during high flow nasal cannula therapy versus CPAP via different masks Preliminary findings on control of dispersion of aerosols and droplets during high-velocity nasal insufflation therapy using a simple surgical mask: implications for the high-flow nasal cannula Acute febrile respiratory illness in the ICU: reducing disease transmission Expert Consensus on Preventing Nosocomial Transmission During Respiratory Care for Critically Ill Patients Infected by 2019 Novel coronavirus pneumonia Everyone with asthma should have a metered dose inhaler and a spacer Nasal high flow in management of children with status asthmaticus: a retrospective observational study Epoprostenol delivered via high flow nasal cannula for ICU subjects with severe hypoxemia comorbid with pulmonary hypertension or right heart dysfunction The clinical impact of flow titration on epoprostenol delivery via high flow nasal cannula for ICU patients with pulmonary hypertension or right ventricular dysfunction: a retrospective cohort comparison study The ratio of nasal cannula gas flow to patient inspiratory flow on trans-nasal pulmonary aerosol delivery for adults: an in vitro study Decrease the flow setting to improve trans-nasal pulmonary aerosol delivery via high-flow nasal cannula to infants and toddlers Effect of noninvasive ventilation delivered by helmet vs face mask on the rate of endotracheal intubation in patients with acute respiratory distress syndrome: a randomized clinical trial Noninvasive ventilation of patients with acute respiratory distress syndrome. Influenza Other Respir Viruses Exhaled air dispersion during noninvasive ventilation via helmets and a total facemask Staff safety during emergency airway management for COVID-19 in Hong Kong Practical recommendations for critical care and anesthesiology teams caring for novel coronavirus (2019-nCoV) patients Emergency tracheal intubation in 202 patients with COVID-19 in Wuhan, China: lessons learnt and international expert recommendations ventilatory and intensive care Expert recommendations for tracheal intubation in critically ill patients with noval coronavirus disease Barrier enclosure during endotracheal intubation New device and technique to protect intubation operators against COVID-19 COVID-19): anesthetic concerns, including airway management and infection control High-flow nasal cannula therapy as apneic oxygenation during endotracheal intubation in critically ill patients in the intensive care unit: a systematic review and metaanalysis Mask ventilation and dispersion of exhaled air Effect of ventilator circuit changes on ventilator-associated pneumonia: a systematic review and meta-analysis Trends in tracheostomy for mechanically ventilated patients in the United States Tracheotomy in ventilated patients with COVID-19 CORONA-steps for tracheotomy in COVID-19 patients: a staff-safe method for airway management Negativepressure aerosol cover for COVID-19 tracheostomy Does endotracheal tube clamping prevent air leaks and maintain positive endexpiratory pressure during the switching of a ventilator in a patient in an intensive care unit? keywords: aerosol; air; covid-19; dispersion; filter; flow; intubation; mask; nasal; patients; respiratory; transmission; ventilation cache: cord-327622-ezgufe24.txt plain text: cord-327622-ezgufe24.txt item: #152 of 177 id: cord-329381-uwae8738 author: Evrard, Bruno title: Cardiovascular phenotypes in ventilated patients with COVID-19 acute respiratory distress syndrome date: 2020-05-18 words: 542 flesch: 23 summary: The higher prevalence of LV failure and lower cardiac index in patients with flu-related ARDS is presumably related to septic cardiomyopathy since they sustained associated septic shock more frequently than COVID-19 patients. COVID-19 patients with ACP tended to have lower respiratory-system compliance than their counterparts, presumably due to distinct ARDS phenotypes [6] . keywords: ards; patients; pressure cache: cord-329381-uwae8738.txt plain text: cord-329381-uwae8738.txt item: #153 of 177 id: cord-331395-12bff84n author: Li, Jingwen title: COVID-19 targets the right lung date: 2020-06-15 words: 938 flesch: 63 summary: In this study, we noticed a side-preference of lung lesions in COVID-19. Moreover, the level of right-over-left preference of lung injury was significantly correlated with the potential need for intensive care and inpatient mortality. keywords: lung; right cache: cord-331395-12bff84n.txt plain text: cord-331395-12bff84n.txt item: #154 of 177 id: cord-331700-5rfgyiit author: Martin, Greg title: Epidemiology studies in critical care date: 2006-04-04 words: 1150 flesch: 30 summary: Critical care epidemiology studies, of which the current study from the Intensive Care National Audit and Research Center database is a good example key: cord-331700-5rfgyiit authors: Martin, Greg title: Epidemiology studies in critical care date: 2006-04-04 journal: Crit Care DOI: 10.1186/cc4897 sha: doc_id: 331700 cord_uid: 5rfgyiit Epidemiology studies are an essential part of clinical research, often forming the foundation for studies ranked more highly in the hierarchy of evidence-based medicine. keywords: epidemiology; sepsis; studies cache: cord-331700-5rfgyiit.txt plain text: cord-331700-5rfgyiit.txt item: #155 of 177 id: cord-334117-8gadvw16 author: Hassanian-Moghaddam, Hossein title: Double trouble: methanol outbreak in the wake of the COVID-19 pandemic in Iran—a cross-sectional assessment date: 2020-07-09 words: 899 flesch: 43 summary: MOH records indicate 5876 hospitalizations for methanol poisoning, occurring in geographical clusters, with just three (Tehran, Fars, Khuzestan) out of the total 31 Iranian provinces accounting for the majority (52.2%; In terms of mortality, MOH reported that 534 patients with methanol poisoning were confirmed dead in the hospital setting, equivalent to an estimated case fatality rate of approximately 9% (534/5876). keywords: covid-19; data; methanol; poisoning cache: cord-334117-8gadvw16.txt plain text: cord-334117-8gadvw16.txt item: #156 of 177 id: cord-334391-0172afa1 author: Gupta, Rahul title: The double edged interferon riddle in COVID-19 pathogenesis date: 2020-11-01 words: 594 flesch: 43 summary: I would like to humbly add some views to it: there has been two varying reported type I interferon responses in COVID-19 pathogenesis [2] : one stating the suppression of host antiviral type I interferons (IFNs) and interferon stimulated genes (ISGs) and other stating increased expression of different ISGs, with further inductions of chemokines and cytokines [2] . key: cord-334391-0172afa1 authors: Gupta, Rahul title: The double edged interferon riddle in COVID-19 pathogenesis date: 2020-11-01 journal: Crit Care DOI: 10.1186/s13054-020-03337-z sha: doc_id: 334391 cord_uid: 0172afa1 nan In their recent article [1] , Jalkanen et al. discuss about the prospective usage of interferon beta 1 in managing COVID-19 and substantiating usage of intravenous route of administration over subcutaneous route. keywords: covid-19; type cache: cord-334391-0172afa1.txt plain text: cord-334391-0172afa1.txt item: #157 of 177 id: cord-335033-cwhm7v0s author: Vergano, Marco title: Clinical ethics recommendations for the allocation of intensive care treatments in exceptional, resource-limited circumstances: the Italian perspective during the COVID-19 epidemic date: 2020-04-22 words: 1550 flesch: 36 summary: In the worst-case scenario of complete saturation of ICU resources, a first come, first served criterion is not recommended, as it would ultimately result in denying access to ICU care to a large number of potentially curable patients. Moreover, the patients who are affected by the application of new, more stringent criteria of eligibility for ICU admission (and/or their proxies) should be Allocation of ICU resources is a complex and delicate task. keywords: admission; care; icu; patients cache: cord-335033-cwhm7v0s.txt plain text: cord-335033-cwhm7v0s.txt item: #158 of 177 id: cord-335172-5ig907on author: Busse, Laurence W. title: COVID-19 and the RAAS—a potential role for angiotensin II? date: 2020-04-07 words: 1671 flesch: 45 summary: Characteristics of and important lessons from the coronavirus disease 2019 (COVID-19) outbreak in China: summary of a report of 72314 cases from the Chinese Center for Disease Control and Prevention Critical care utilization for the COVID-19 outbreak in Lombardy, Italy: early experience and forecast during an emergency response Clinical characteristics of 138 hospitalized patients with 2019 novel coronavirus-infected pneumonia in Care for critically ill patients with COVID-19 Clinical characteristics of coronavirus disease 2019 in China SARS-CoV-2 CellEntry Depends on ACE2 and TMPRSS2 and Is Blocked by a Clinically Proven Protease Inhibitor Cryo-EM structure of the 2019-nCoV spike in the prefusion conformation A familial cluster of pneumonia associated with the 2019 novel coronavirus indicating person-to-person transmission: a study of a family cluster Susceptibility to SARS coronavirus S protein-driven infection correlates with expression of angiotensin converting enzyme 2 and infection can be blocked by soluble receptor Angiotensin-converting enzyme 2 is a functional receptor for the SARS coronavirus Angiotensin converting enzyme defects in shock: implications for future therapy Angiotensin II up-regulates angiotensin I-converting enzyme (ACE), but down-regulates ACE2 via the AT1-ERK/p38 MAP kinase pathway Aerobic exercise traininginduced left ventricular hypertrophy involves regulatory MicroRNAs, decreased angiotensin-converting enzyme-angiotensin ii, and synergistic regulation of angiotensin-converting enzyme 2-angiotensin Effect of angiotensin-converting enzyme inhibition and angiotensin II receptor blockers on cardiac angiotensin-converting enzyme 2 Upregulation of angiotensin-converting enzyme 2 after myocardial infarction by blockade of angiotensin II receptors Publisher's Note Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations Authors' contributions All authors were major contributors in writing the manuscript. Table 1 Information supporting the use of angiotensin II in COVID-19 disease Increased ACE2 increases infectivity of SARS [6, 10] Decreased ACE2 expression decreases infectivity of SARS [6, 10] SARS-CoV-2 utilizes ACE2 to enter cells like SARS-CoV-1 keywords: ace2; angiotensin; cov-2; patients; sars cache: cord-335172-5ig907on.txt plain text: cord-335172-5ig907on.txt item: #159 of 177 id: cord-336314-xf6zvvl8 author: Hu, Lijuan title: Clinical analysis of sinus bradycardia in patients with severe COVID-19 pneumonia date: 2020-05-26 words: 898 flesch: 42 summary: The initial manifestation of severe COVID-19 pneumonia patients was hypoxemic respiratory failure, accompanied by rapid increased reactive heart rate and susceptibility to supraventricular arrhythmia Taken together, heart rate monitoring of severe COVID-19 pneumonia patients should be strengthened during treatment, and catecholamines should be appropriately applied when necessary. keywords: bradycardia; patients; sinus cache: cord-336314-xf6zvvl8.txt plain text: cord-336314-xf6zvvl8.txt item: #160 of 177 id: cord-337444-pqoq8aew author: Doi, Kent title: Nafamostat mesylate treatment in combination with favipiravir for patients critically ill with Covid-19: a case series date: 2020-07-03 words: 990 flesch: 37 summary: This is the first report on nafamostat mesylate treatment in combination with favipiravir against Covid-19. key: cord-337444-pqoq8aew authors: Doi, Kent; Ikeda, Mahoko; Hayase, Naoki; Moriya, Kyoji; Morimura, Naoto title: Nafamostat mesylate treatment in combination with favipiravir for patients critically ill with Covid-19: a case series date: 2020-07-03 journal: Crit Care DOI: 10.1186/s13054-020-03078-z sha: doc_id: 337444 cord_uid: pqoq8aew nan Development of specific therapy against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is urgently required. keywords: mesylate; nafamostat; treatment cache: cord-337444-pqoq8aew.txt plain text: cord-337444-pqoq8aew.txt item: #161 of 177 id: cord-337485-nqcnd9py author: Buetti, Niccolò title: SARS-CoV-2 detection in the lower respiratory tract of invasively ventilated ARDS patients date: 2020-10-16 words: 2149 flesch: 45 summary: 1186/s13054-020-03323-5. Additional file 1. Assessment of deaths from COVID-19 and from seasonal influenza Viral load dynamics and disease severity in patients infected with SARS-CoV-2 in Zhejiang province, China Quantitative detection and viral load analysis of SARS-CoV-2 in infected patients Comparisons of viral shedding time of SARS-CoV-2 of different samples in ICU and non-ICU patients Virological assessment of hospitalized patients with COVID-2019 SARS-CoV-2 viral load in clinical samples from critically ill patients SARS-CoV-2 viral load predicts COVID-19 mortality Guidance for discharge and ending isolation in the context of widespread community transmission of COVID-19 Clinical and virological data of the first cases of COVID-19 in Europe: a case series Viral load of SARS-CoV-2 in clinical samples Diabetes mellitus is a risk factor for prolonged SARS-CoV-2 viral shedding in lower respiratory tract samples of critically ill patients Risk factors for viral RNA shedding in COVID-19 patients Factors associated with prolonged viral RNA shedding in patients with COVID-19 Profile of RT-PCR for SARS-CoV-2: a preliminary study from 56 COVID-19 patients Factors associated with duration of viral shedding in adults with COVID-19 outside of Wuhan, China: a retrospective cohort study Strengthening the Reporting of Observational Studies in Epidemiology (STROBE) statement: guidelines for reporting observational studies COVID-19 illness in native and immunosuppressed states: a clinical-therapeutic staging proposal Tocilizumab for the treatment of severe COVID-19 pneumonia with hyperinflammatory syndrome and acute respiratory failure: a single center study of 100 patients in Factors associated with prolonged viral shedding and impact of lopinavir/ritonavir treatment in hospitalised non-critically ill patients with SARS-CoV-2 infection Publisher's Note Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations Several authors suggested that viral shedding and severity of disease might be correlated [2] , but they mostly focused on viral presence in upper respiratory secretions [3, 4] . keywords: covid-19; load; lrt; patients; sars; shedding cache: cord-337485-nqcnd9py.txt plain text: cord-337485-nqcnd9py.txt item: #162 of 177 id: cord-338134-smrokdsq author: Honore, Patrick M. title: Therapeutic plasma exchange as a routine therapy in septic shock and as an experimental treatment for COVID-19: we are not sure date: 2020-05-15 words: 1009 flesch: 42 summary: key: cord-338134-smrokdsq authors: Honore, Patrick M.; Mugisha, Aude; Kugener, Luc; Redant, Sebastien; Attou, Rachid; Gallerani, Andrea; De Bels, David title: Therapeutic plasma exchange as a routine therapy in septic shock and as an experimental treatment for COVID-19: we are not sure date: 2020-05-15 journal: Crit Care DOI: 10.1186/s13054-020-02943-1 sha: doc_id: 338134 cord_uid: smrokdsq nan Therapeutic plasma exchange as a routine therapy in septic shock and as an experimental treatment for COVID-19: we are not sure Patrick M. Honore * , Aude Mugisha, Luc Kugener, Sebastien Redant, Rachid Attou, Andrea Gallerani and David De Bels We read with interest the recent editorial by Keith et al. who concluded that their practice has changed based on their experience, and they now often utilize therapeutic plasma exchange (TPE) earlier in the clinical course of septic shock with multiple organ failure (MODS) and acute respiratory distress syndrome (ARDS) rather than using it as a rescue therapy Fresh frozen plasma A novel treatment approach to the novel coronavirus: an argument for the use of therapeutic plasma exchange for fulminant COVID-19 Early therapeutic plasma exchange in septic shock: a prospective open-label nonrandomized pilot study focusing on safety, hemodynamics, vascular barrier function, and biologic markers The efficacy and safety of plasma exchange in patients with sepsis and septic shock: a systematic review and meta-analysis Complications in patients treated with plasmapheresis in the intensive care unit Presenting characteristics, comorbidities, and outcomes among 5700 patients hospitalized with COVID-19 in the New York City area Publisher's Note Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations None. Authors' contributions PMH, SR, and DDB designed the paper. keywords: patients; plasma; tpe cache: cord-338134-smrokdsq.txt plain text: cord-338134-smrokdsq.txt item: #163 of 177 id: cord-338990-vrtzyo2o author: Nelson, Sarah E. title: COVID-19 and ethics in the ICU date: 2020-08-25 words: 1229 flesch: 43 summary: Based on these principles, 6 recommendations have been made for the current outbreak: maximizing benefits including using scarce resources responsibly and saving more lives/years of life, prioritizing COVID-19 resources (i.e., PPE, vaccines) to healthcare workers, invoking equality using random allocation or lottery to distribute resources to those with similar prognoses, thoughtful consideration of resource allocation (e.g., prioritizing older patients, among the most affected by SARS-CoV-2, to receive a vaccine), prioritizing those who have participated in COVID-19-related research, and providing equal resources to those with COVID-19 and those with other medical conditions [9] . The hippocratic oath today COVID-19: protecting health-care workers Memoriam: Healthcare workers who have died of COVID-19 Physicians are disposable and are taken for granted Facing Covid-19 in Italy -ethics, logistics, and therapeutics on the epidemic's front line Scarce resource allocation during disasters: a mixed-method community engagement study Too many patients … a framework to guide statewide allocation of scarce mechanical ventilation during disasters Fair allocation of scarce medical resources in the time of Covid-19 The toughest triage -allocating ventilators in a pandemic Considerations for ventilator triage during the COVID-19 pandemic The psychological trauma that awaits our doctors and nurses Not dying alone -modern compassionate care in the Covid-19 pandemic I'm on the front lines. keywords: care; covid-19; resources cache: cord-338990-vrtzyo2o.txt plain text: cord-338990-vrtzyo2o.txt item: #164 of 177 id: cord-340205-cwn0gx7h author: Chen, Yih-Ting title: Mortality rate of acute kidney injury in SARS, MERS, and COVID-19 infection: a systematic review and meta-analysis date: 2020-07-16 words: 952 flesch: 20 summary: The present analyses indicate AKI as a poor prognosis factor in coronavirus infections, whereby AKI mortality in COVID-19 is higher than MERS but lower than SARS infections. key: cord-340205-cwn0gx7h authors: Chen, Yih-Ting; Shao, Shih-Chieh; Lai, Edward Chia-Cheng; Hung, Ming-Jui; Chen, Yung-Chang title: Mortality rate of acute kidney injury in SARS, MERS, and COVID-19 infection: a systematic review and meta-analysis date: 2020-07-16 journal: Crit Care DOI: 10.1186/s13054-020-03134-8 sha: doc_id: 340205 cord_uid: cwn0gx7h nan and independently assessed the full texts of selected results. keywords: coronavirus; covid-19; patients cache: cord-340205-cwn0gx7h.txt plain text: cord-340205-cwn0gx7h.txt item: #165 of 177 id: cord-341063-3rqnu5bu author: None title: 38th International Symposium on Intensive Care and Emergency Medicine: Brussels, Belgium. 20-23 March 2018 date: 2018-03-29 words: 98736 flesch: 48 summary: Since altered liver function has also been described in ICU patients without sepsis [1, 2] , the influence of sepsis may be overestimated. The aim of this work is to analyze the connection between serum and fecal levels of AMM in ICU patients. keywords: acute; admission; adult patients; age; aim; aki; analysis; ards; arrest; assessment; baseline; blood; brain; cardiac; care; care patients; care unit; cases; changes; clinical; cohort; complications; conclusions; control; correlation; criteria; critical; data; day mortality; days; decrease; diagnosis; difference; discharge; duration; dysfunction; early; effect; emergency; end; factors; failure; fig; flow; fluid; following; group; hospital; hospital mortality; hours; icu admission; icu mortality; icu patients; icu stay; impact; incidence; increase; infection; injury; introduction; length; levels; lung; mean; median; medical; methods; min; model; months; mortality; non; organ; outcome; p<0.001; parameters; patients; period; population; post; pressure; protocol; rate; renal; results; risk; risk patients; score; sepsis; septic; severity; shock; significant; sofa; stay; studies; study; support; surgery; surgery patients; survival; survivors; table; test; therapy; time; total; transfusion; treatment; unit; use; value; ventilation; volume; years cache: cord-341063-3rqnu5bu.txt plain text: cord-341063-3rqnu5bu.txt item: #166 of 177 id: cord-343940-fdnmeuh8 author: Tzotzos, Susan J. title: Incidence of ARDS and outcomes in hospitalized patients with COVID-19: a global literature survey date: 2020-08-21 words: 655 flesch: 33 summary: The mortality rate of ICU COVID-19 patients is 40% and of those who receive IMV 59%; the mortality rate in COVID-19-associated ARDS is 45%, and the incidence of ARDS among non-survivors of COVID-19 is 90% ( Table 2 ). Calculation of weighted averages for these parameters incorporating data from individual studies for which data is available indicate that among hospitalized COVID-19 patients, approximately 1/3 (33%) develop ARDS, 1/4 (26%) require transfer to Patient numbers for Chen T study not included an ICU, 1/6 (16%) receive IMV, and 1/6 (16%) die (Table 1 ). keywords: covid-19; patients cache: cord-343940-fdnmeuh8.txt plain text: cord-343940-fdnmeuh8.txt item: #167 of 177 id: cord-344965-h945xi7y author: Wang, Ying title: Pooled prevalence of deep vein thrombosis among coronavirus disease 2019 patients date: 2020-07-28 words: 891 flesch: 55 summary: The meta-regression and subgroup analysis were used to investigate the potential heterogeneity sources (such as sample size, prevalence of prophylaxis in COVID-19 patients, location, design of studies, screening methods of DVT, and COVID-19 patients in intensive care unit (ICU)). According to patients' geographic location, the much higher pooled prevalence of DVT was found in COVID-19 patients from China (30%, 95% CI 2-72%, P = 0.02, I 2 = 98.73%, Q = 313.90, P < 0.01) compared with those from western countries (13%, 95% CI 8-19%, P < 0.01, I 2 = 95.62%, Q = 502.07, P < 0.01) (Fig. 1b) . keywords: covid-19; patients cache: cord-344965-h945xi7y.txt plain text: cord-344965-h945xi7y.txt item: #168 of 177 id: cord-345973-fb3gkc0f author: Thibault, Ronan title: Nutrition of the COVID-19 patient in the intensive care unit (ICU): a practical guidance date: 2020-07-19 words: 4847 flesch: 42 summary: All over the world, ICU COVID-19 patients are rather similar in terms of vulnerability (older, chronic diseases, low food intake for 5-10 days) To our knowledge, there is no specific indication for arginine in ICU COVID-19 patients. keywords: case; covid-19; icu; malnutrition; nutrition; patients; risk; sars; use cache: cord-345973-fb3gkc0f.txt plain text: cord-345973-fb3gkc0f.txt item: #169 of 177 id: cord-346307-xejs2va1 author: Rysz, Susanne title: Treatment with angiotensin II in COVID-19 patients may not be beneficial date: 2020-09-04 words: 818 flesch: 46 summary: Until more relevant experiments are performed or clear evidence emerges that angiotensin II infusion is injurious in COVID-19 patients, the data are strong that angiotensin II is a safe and effective vasopressor agent [8] especially in patients with high renin levels [9] . Angiotensin II infusion in COVID-19-associated vasodilatory shock: a case series Brings more questions than answers Angiotensin-converting enzyme 2: SARS-CoV-2 receptor and regulator of the renin-angiotensin system: celebrating the 20th anniversary of the discovery of ACE2 Clinical and biochemical indexes from 2019-nCoV infected patients linked to viral loads and lung injury COVID-19 pathophysiology may be driven by a loss of inhibition of the renin-angiotensin-aldosterone system. key: cord-346307-xejs2va1 authors: Rysz, Susanne; Jalde, Francesca Campoccia; Oldner, Anders; Eriksson, Lars I.; Lundberg, Johan; Fagerlund, Malin Jonsson title: Treatment with angiotensin II in COVID-19 patients may not be beneficial date: 2020-09-04 journal: Crit Care DOI: 10.1186/s13054-020-03233-6 sha: doc_id: 346307 cord_uid: xejs2va1 nan We read with great interest the recent article by Zangrillo et al. regarding infusion of angiotensin II (ANGII) in COVID-19 keywords: angiotensin; covid-19 cache: cord-346307-xejs2va1.txt plain text: cord-346307-xejs2va1.txt item: #170 of 177 id: cord-346394-rk8jkf19 author: Pinkham, Maximilian title: Effect of flow and cannula size on generated pressure during nasal high flow date: 2020-05-24 words: 873 flesch: 53 summary: The data show that in order to deliver higher pressure during NHF, then the flow rate and/or cannula size need to be increased. As shown in Fig. 1 , NHF generates greater pressure when delivered using a larger cannula and with higher flow rate. keywords: cannula; pressure cache: cord-346394-rk8jkf19.txt plain text: cord-346394-rk8jkf19.txt item: #171 of 177 id: cord-347833-b3yrxkt0 author: Ahlström, Björn title: A nationwide study of the long-term prevalence of dementia and its risk factors in the Swedish intensive care cohort date: 2020-09-04 words: 4346 flesch: 50 summary: Such an approach allows for an accurate assessment of comorbidities in general and pre ICU dementia in particular. The date of dementia diagnosis was the first occurrence of the condition in the NPR or the SveDem. keywords: care; cohort; dementia; diagnosis; icu; patients; risk; sepsis cache: cord-347833-b3yrxkt0.txt plain text: cord-347833-b3yrxkt0.txt item: #172 of 177 id: cord-351264-zp41u14l author: Quah, Pipetius title: Mortality rates of patients with COVID-19 in the intensive care unit: a systematic review of the emerging literature date: 2020-06-04 words: 701 flesch: 48 summary: Third, 29% of the ICU patients who died in the Chinese studies did not receive mechanical ventilation, and where systems experienced a surge of critically ill patients, up to 53.2% of patients who required ICU care were unable to receive it because of resource constraints We thus aimed to review the outcomes of ICU patients with COVID-19 from the existing literature. keywords: icu; patients cache: cord-351264-zp41u14l.txt plain text: cord-351264-zp41u14l.txt item: #173 of 177 id: cord-351600-bqw9ks4a author: Zhang, Shuai title: Development and validation of a risk factor-based system to predict short-term survival in adult hospitalized patients with COVID-19: a multicenter, retrospective, cohort study date: 2020-07-16 words: 4972 flesch: 42 summary: In patients with COVID-19, plasma LDH level was reported to be higher in severe, ICU, and deceased COVID-19 patients than in mild, non-ICU-patients, and survivors In this study, we employed the clinical and laboratory features of COVID-19 patients to work out an effective and easy tool for predicting 28-day mortality. keywords: cohort; covid-19; day; hospital; mortality; patients; study; survival; wuhan cache: cord-351600-bqw9ks4a.txt plain text: cord-351600-bqw9ks4a.txt item: #174 of 177 id: cord-352227-827987jf author: Chernevskaya, Ekaterina title: Serum and fecal profiles of aromatic microbial metabolites reflect gut microbiota disruption in critically ill patients: a prospective observational pilot study date: 2020-06-08 words: 6464 flesch: 41 summary: Blood (from a central venous catheter) and gut microbiome samples were collected in the morning at regular intervals: in ACI patients-on days 1, 3, and 7-9 after the diagnosis of pneumonia; in CCI patients-once a week for a month. To compare serum metabolite levels, we used serum samples from 23 healthy volunteers (for 5 of them, fecal samples were also collected on the same day). keywords: acid; amm; associations; cci; feces; group; gut; levels; metabolites; microbial; microbiota; patients; serum cache: cord-352227-827987jf.txt plain text: cord-352227-827987jf.txt item: #175 of 177 id: cord-353344-tzyu6j6n author: van Berkel, Miranda title: Biomarkers for antimicrobial stewardship: a reappraisal in COVID-19 times? date: 2020-10-06 words: 1085 flesch: 47 summary: PCT appears to increase in COVID patients with severe disease and/or in those presenting with secondary bacterial infections [6] . Furthermore, our data show that, during ICU admission, PCT levels of > 1.00 μg/L rule in, whereas concentrations of < 0.25 μg/L rule out secondary bacterial infections with good predictive values. keywords: day; infection; pct cache: cord-353344-tzyu6j6n.txt plain text: cord-353344-tzyu6j6n.txt item: #176 of 177 id: cord-354355-i6ot4ef8 author: Decavele, Maxens title: Endobronchial ultrasound is feasible and safe to diagnose pulmonary embolism in non-transportable SARS-CoV-2 ARDS patients requiring extracorporeal lung support date: 2020-09-21 words: 980 flesch: 40 summary: Here, we describe the feasibility, safety, and diagnostic accuracy of endobronchial ultrasound (EBUS) to detect PE in patients with severe SARS-CoV-2 ARDS requiring vv-ECMO. Patients were mostly men (n = 10), 52 keywords: ctpa; ebus; fees; patients cache: cord-354355-i6ot4ef8.txt plain text: cord-354355-i6ot4ef8.txt item: #177 of 177 id: cord-355847-1ru15s5a author: Convertino, Irma title: Exploring pharmacological approaches for managing cytokine storm associated with pneumonia and acute respiratory distress syndrome in COVID-19 patients date: 2020-06-11 words: 2944 flesch: 35 summary: Several drugs, endowed with modulating activity on cytokine pathways, including anti-IL-6, anti-TNF, and Janus kinase (JAK) inhibitors, currently approved for the treatment of immune-mediated inflammatory diseases, have been suggested or could be yet taken into account for experimental use in COVID-19 patients with ARDS and/or pneumonia ( Fig. 1 ). Moreover, a multicenter randomized clinical trial in COVID-19 patients with ARDS, treated with tocilizumab at a dose of 4~8 mg/kg once, and an additional same dose when fever persists within 24 h after the first administration, has been approved in China [16] . keywords: anti; ards; covid-19; il-6; iqr; patients; tnf cache: cord-355847-1ru15s5a.txt plain text: cord-355847-1ru15s5a.txt