ISSN 1978 - 3728Volume 46, Number 4, December 2013

EDITORIAL BOARD OF DENTAL JOURNAL (MAJALAH KEDOKTERAN GIGI) 
SK: 52/H3.1.2/KD/2011

May 2nd, 2011 – May 2nd, 2013

Patron: 
Dean of Faculty of Dental Medicine Universitas Airlangga 

Advisors:
Vice Dean I, Vice Dean II, Vice Dean III 

Chief Editor:
Udijanto Tedjosasongko, drg., Ph.D., Sp.KGA(K)

(Pediatric Dentistry – Universitas Airlangga)

Editorial Boards:
Prof. R.M. Coen Pramono D, drg., SU., Sp.,BM(K) (Oral and Maxillofacial Surgery – Universitas Airlangga); Prof. Dr. M. Rubianto, drg., MS., Sp.Perio(K) 
(Periodontic – Universitas Airlangga); Prof. Nairn Hutchinson Fulton Wilson, MSc., Ph.D., FDS (Conservative Dentistry - University of Guy’s Dental School, 
London); Prof. W.J. Spitzer, DMD., MD (Head Department of Cranio & Oral Maxillofacial Surgery Hamburg University, Germany); Prof. Edward C. Combe, 
MSc., Ph.D., DDSc (Biomaterial – Minnesota University, U.S.A); Prof. Madya. H. AB. Rani Samsudin, DDS., FDSRC, AM (Oral and Maxillofacial Surgery - 
University Sains, Malaysia); Prof. Widowati Witjaksono, DDS., Ph.D (Kulliyah of Dentistry, International Islamic University Malaysia); Prof. Taizo Hamada, 
DDS., Ph.D (Prosthodontic - Tohoku University, Japan); Prof. Yukio Kato, DDS., Ph.D. (Oral Bio Chemistry-University of Hiroshima, Japan); Prof. Kozai 
Katsuyuki, DDS., Ph.D (Pediatric Dentistry – University of Hiroshima, Japan); Prof. dr. A.G.M. Tielens (Medical Microbiology – University and Infections 
Diseases – Erasmus University Medical Centre, Rotterdam, The Netherlands); Prof. Lakshman Samaranayake (Oral Microbiology – The University of 
Hongkong); Kok Van Kesel (Medical Microbiology – University and Infections Diseases – Erasmus University Medical Centre, Rotterdam, The Netherlands); 
Dr. Leslie Ang (Restorative Dentistry – National Dental Centre of Singapore); Prof. Dr. M. Suharsini, drg., MS., Sp.KGA (Pediatric Dentistry - Universitas 
Indonesia); Achmad Gunadi, drg., MS., Ph.D (Prosthodontic - Universitas Negeri Jember)

Managing Editors:
Prof. Dr. Arifzan Razak, drg., MSc., Sp.Pros (Prosthodontics – Universitas Airlangga); Prof. Dr. Latief Mooduto, drg., M.S., Sp.KG(K) (Conservative 
Dentistry – Universitas Airlangga); Prof. Dr. Mieke Sylvia M.A.R., drg., MS., Sp.Ort(K) (Orthodontic – Universitas Airlangga); Prof. Dr. Istiati Soehardjo, 
drg., MS (Oral Biology – Universitas Airlangga); Prof. Dr. Anita Yuliati, drg., M.Kes (Dental Material – Universitas Airlangga); Prof. Seno Pradopo, drg, 
SU., Ph.D., Sp.KGA (Pediatric Dentistry – Universitas Airlangga); Prof. Dr. Diah Savitri Ernawati, drg., M.Si., Sp.PM(K) (Oral Medicine – Universitas 
Airlangga); Prof. Thalca I. Agusni, drg., MHPEd., Ph.D., Sp.Ort(K) (Orthodontic – Universitas Airlangga); Dr. R. Darmawan Setijanto, drg., M.Kes 
(Dental Public Health – Universitas Airlangga); Dr. Elly Munadziroh, drg., MS (Dental Material – Universitas Airlangga); Priyawan Rachmadi, drg., Ph.D 
(Dental Material – Universitas Airlangga); Dr. Retno Pudji Rahayu, drg., M.Kes (Oral Biology – Universitas Airlangga); Dr. Eha Renwi Astuti, drg., M.Kes 
(Dental Radiology – Universitas Airlangga); Bagus Soebadi, drg., MHPEd., Sp.PM (Oral Medicine – Universitas Airlangga); Endang Pudjirochani, drg., 
MS., Sp.Pros (Prosthodontic – Universitas Airlangga); Markus Budi Rahardjo, drg., M.Kes (Oral Biology – Universitas Airlangga); Dr. Susy Kristiani, drg., 
M.Kes (Oral Biology – Universitas Airlangga); Dr. Ira Widjiastuti, drg., M.Kes., Sp.KG (Conservative Dentistry – Universitas Airlangga); Ketut Suardita, 
drg., Ph.D., Sp.KG. (Conservative Dentistry – Universitas Airlangga); Sianiwati Goenharto, drg., MS (Orthodontic – Universitas Airlangga); Devi Rianti, drg., 
M.Kes (Dental Material – Universitas Airlangga); Dr. Chiquita Prahasanti, drg., Sp.Perio(K) (Periodontic – Universitas Airlangga); Rostiny, drg., M.Kes., 
Sp.Pros(K) (Prosthodontic – Universitas Airlangga); An’nissa Chusida, drg., M.Kes (Oral Biology – Universitas Airlangga); Eric Priyo Prasetyo, drg., 
Sp.KG (Conservative Dentistry – Universitas Airlangga); Els Sunarsih Budipramana, drg., MS., Sp.KGA(K) (Pediatric Dentistry – Universitas Airlangga); 
Dr. Hendrik Setiabudi, drg., M.Kes (Oral Biology – Universitas Airlangga); Otty Ratna Wahyuni, drg., M.Kes (Dental Radiology – Universitas Airlangga); 
Anis Irmawati, drg., M.Kes (Oral Biology – Universitas Airlangga); Yuliati, drg., M.Kes (Oral Biology – Universitas Airlangga); Retno Palupi, drg., M.Kes 
(Dental Public Health – Universitas Airlangga); Eka Augustina, drg., Sp.Perio (Periodontica – Universitas Airlangga); Febriastuti, drg., Sp.KG (Conservative 
Dentistry – Universitas Airlangga); Mega M. Puteri, drg., Sp.KGA (Pediatric Dentistry – Universitas Airlangga)

Administrative Assistant:
Novi Dian Prastiwi (Faculty of Dental Medicine – Airlangga University) 

Thanks to editor in duty of Dental Journal (Majalah Kedokteran Gigi) Volume 46 Number 4 December 2013: 

Prof. Dr. Mandojo Rukmo, drg., MSc., Sp.KG(K) (Conservative Dentistry – Universitas Airlangga)
Prof. Dr. Adioro Soetojo, drg., MS., Sp.KG(K) (Conservative Dentistry – Universitas Airlangga)

Dr. Theresia Indah Budhy, drg., M.Kes  (Oral Pathology and Maxillofacial – Universitas Airlangga)
Dr. Indah Listiana Kriswandini, drg., M.Kes (Oral Biology – Universitas Airlangga)

Dr. Ernie Maduratna Setiawatie, drg., M.Kes., Sp.Perio (Periodontic – Universitas Airlangga)

Editorial Address c/o:  Fakultas Kedokteran Gigi Universitas Airlangga
 Jln. Mayjen. Prof. Dr. Moestopo No. 47 Surabaya 60132, INDONESIA
 Telp. (062-31) 5039478/5030255. Fax. (031) 5039478/5020256
 E-mail: dental_journal@yahoo.com Website: www.journal.unair.ac.id

 Accredited No. 56/DIKTI/Kep/2012

 Cover photo purchased from: www.folia.com
 Invoice number: 206708019-204225738



CONTENTS

 Page

Printed by: Airlangga University Press. (RK 234/07.14/AUP-A45E). Kampus C Unair, Mulyorejo Surabaya 60115, Indonesia.  
Telp. (031) 5992246, 5992247, Telp./Fax. (031) 5992248. E-mail: aupsby@rad.net.id; aup.unair@gmail.com 

Accredited No. 56/DIKTI/Kep/2012.

Volume 46, Number 4, December 2013   ISSN 1978 - 3728

 1. Ekspresi COX-2 setelah pemberian ekstrak etanolik kulit manggis (Garcinia mangostana Linn) 
pada tikus wistar

  (COX-2 expression after mangosteen rind (Garcinia mangostana Linn) etanolic extract administration 
in wistar rats) 
Rendra Chriestedy Prasetya, Tetiana Haniastuti, dan Nunuk Purwanti ................................... 173–178

 2. Profil jaringan lunak wajah kasus borderline maloklusi klas I pada perawatan ortodonti dengan dan 
tanpa pencabutan gigi

  (Facial soft tissue profile on borderline class I malocclusion in orthodontic treatment with or without 
teeth extraction)
Pinandi Sri Pudyani dan Yenni Hanimastuti ................................................................................. 179–184

 3. Minyak ikan Lemuru (Sardinella longicep) menurunkan apoptosis osteoblas pada tulang alveolaris 
tikus wistar

  (Fish oil of Lemuru (Sardinella longicep) reduced the osteoblast apoptosis in wistar rat alveolar 
bone)
Didin Erma Indahyani ..................................................................................................................... 185–189

 4. Respon inflamasi pulpa gigi tikus Sprague Dawley setelah aplikasi bahan etsa ethylene diamine 
tetraacetic acid 19% dan asam fosfat 37%

  (Dental pulp inflammatory response of Sprague Dawley rats after etching application of 19% 
ethylene diamine tetraacetic acid and 37% phosphoric acid)
Nadie Fatimatuzzahro, Tetiana Haniastuti dan Juni Handajani ................................................. 190–195

 5. Efek ekstrak daun singkong (Manihot utilissima) terhadap ekspresi COX-2 pada monosit yang 
dipapar LPS E.coli

  (The effect of Manihot utilissima extracts on COX-2 expression of monocytes induced by LPS E. 
coli)
Zahara Meilawaty ............................................................................................................................ 196–201

 6. The effect of CPP-ACP containing fluoride on Streptococcus mutans adhesion and  enamel roughness 
Yulita Kristanti, Widya Asmara, Siti Sunarintyas, and Juni Handajani .................................... 202–206

 7. Sifat fisik hidroksiapatit sintesis kalsit sebagai bahan pengisi pada sealer saluran akar resin epoxy
  (Physical properties of calcite synthesized hydroxyapatite as the filler of epoxy-resin-based root 

canal sealer)
Ema Mulyawati, Marsetyawan HNES, Siti Sunarintyas, dan Juni Handajani .......................... 207.–212

 8. Prevotella intermedia and Porphyromonas gingivalis in dental caries with periapical granuloma
Risya Cilmiaty, Afiono Agung Prasetyo,Khilyat Ulin Nur Zaini, Mandojo Rukmo, 
Suhartono Taat Putra and Widya Asmara  ................................................................................... 213–217



 9. Antifungal effect of Sticophus hermanii and Holothuria atra extract and its cytotoxicity on gingiva-
derived mesenchymal stem cell
Kristanti Parisihni and Syamsulina Revianti ................................................................................ 218–223

 10. Korelasi indeks morfologi wajah dengan sudut interinsisal dan tinggi wajah secara sefalometri
  (Cephalometric correlation of facial morphology index with interincisal angle and facial height) 

Pricillia Priska Sianita K dan Verenna  ......................................................................................... 224–228

 11. Orthodontic-surgical treatment of  a severe class III malocclusion
Pakpahan Evie Lamtiur   ................................................................................................................ 229–234