Vol 49 No 1 Jan-Mrt 2016.indd p-ISSN: 1978-3728 e-ISSN: 2442-9740 Volume 49, Number 1, March 2016 EDITORIAL BOARDS OF DENTAL JOURNAL (MAJALAH KEDOKTERAN GIGI) SK: 04/UN3.1.2/2016 January 2nd – December 31st, 2016 Patron: Dean of Faculty of Dental Medicine, Universitas Airlangga Advisors: Vice Dean I, Vice Dean II, Vice Dean III of Faculty of Dental Medicine, Universitas Airlangga Chief Editor: Ketut Suardita (Department of Conservative Dentistry - Faculty of Dental Medicine, Universitas Airlangga) Editorial Boards: Roeland Jozef Gentil De Moor (Department of Restorative dentistry and Endodontology, Dental School, Ghent University, Belgium); Cortino Sukotjo (University of Illinois at Chicago College of Dentistry, Department of Restorative Dentistry, Chicago, United States); Guang Hong (Liaison Center for Innovative Dentistry, Graduate School of Dentistry, Tohoku University, Japan); Hamid Nurrohman (Missouri School of Dentistry & Oral Health A.T. Still University 800 W. Jefferson St. Kirksville, Missouri, USA, United States); Harry Huiz Peeters (Laser Research Center, Bandung, Indonesia); Elza Ibrahim Auerkari (Department of Oral Biology, Faculty of Dentistry, Universitas Indonesia, Indonesia); Boy Muchlis Bachtiar (Department of Oral Biology Faculty of Dentistry, Universitas Indonesia, Indonesia); Boedi Oetomo Roeslan (epartment of Biochemistry Faculty of Dentistry, Universitas Trisakti); Rahmi Amtha (Department of Oral Medicine Faculty of Dentistry, Universitas Trisakti, Indonesia); Fajar Hamonangan Nasution (Department of Orthodontics Faculty of Dentistry, Universitas Trisakti, Indonesia); Anita Yuliati (Department of Dental Material Faculty of dental Medicine, Universitas Airlangga, Indonesia); Darmawan Setijanto (Department of Dental Public Health Faculty of Dental Medicine, Universitas Airlangga, Indonesia); Widowati Witjaksono (Kulliyah of Dentistry, International Islamic University Malaysia, Malaysia); Pinandi Sri Pudyani (Department of Orthodontics Faculty of Dentistry, Universitas Gadjah Mada, Indonesia) Managing Editors: Hendrik Setia Budi (Department of Oral Biology, Faculty of Dental Medicine, Universitas Airlangga, Indonesia); Ira Widjiastuti (Department of Conservative Dentistry, Faculty of Dental Medicine, Universitas Airlangga, Indonesia); Markus Budi Rahardjo (Department of Oral Biology, Faculty of Dental Medicine); Anis Irmawati (Department of Oral Biology, Faculty of Dental Medicine, Universitas Airlangga, Indonesia) Assistant Editors Saka Winias (Department of Oral Medicine, Faculty of Dental Medicine, Universitas Airlangga, Indonesia); Eric Prasetyo (Department of Conservative Dentistry, Faculty of Dental Medicine, Universitas Airlangga, Indonesia) Peer-Reviewers Jenny Sunariani (Department of Oral Biology, Faculty of Dental Medicine, Universitas Airlangga, Indonesia); Haslinda Z Tamin (Department of Periodontics, Faculty of Dentistry, Universitas Airlangga, Indonesia); David B. Kamadjaja (Department of Oral and Maxillofacial Surgery, Faculty of Dental Medicine, Universitas Airlangga, Indonesia); Tri Murni Abidin (Department of Conservative Dentistry Faculty of Dentistry, Universitas Sumatera Utara, Indonesia); Agung Krismariono (Department of Periodontics, Faculty of Dental Medicine, Universitas Airlangga, Indonesia); Sri Kunarti (Department of Conservative Dentistry, Faculty of Dental Medicine, Universitas Airlangga, Indonesia); Istiati (Department of Oral Patology and Maxillofacial, Faculty of Dental Medicine, Universitas Airlangga, Indonesia); Adioro Soetojo (Department of Conservative Dentistry, Faculty of Dental Medicine, Universitas Airlangga, Indonesia); Diah Savitri Ernawati (Department of Oral Medicine Faculty of Dental Medicine, Universitas Airlangga, Indonesia); Chiquita Prahasanti (Department of Periodontics, Faculty of Dental Medicine, Universitas Airlangga, Indonesia); Theresia Indah Budhy (Department of Oral Pathology, Faculty of Dental Medicine, Universitas Airlangga, Indonesia); Wisnu Setyari (Department of Oral Biology, Faculty of Dental Medicine, Universitas Airlangga, Indonesia); Ira Arundina (Department of Oral Biology, Faculty of Dental Medicine, Universitas Airlangga, Indonesia); Yuniardini Septorini Wimardhani (Department of Oral Medicine, Faculty of Dentistry, Universitas Indonesia, Indonesia) Administrative Assistant: Novi Dian Prastiwi (Faculty of Dental Medicine, Universitas Airlangga) Editorial Address: Faculty of Dental Medicine Universitas Airlangga Jln. Mayjen. Prof. Dr. Moestopo No. 47 Surabaya 60132, INDONESIA Telp. (+6231) 5039478/ 5030255. Fax. (031) 5039478/ 5020256 E-mail: dental_journal@yahoo.com; Website: www.e-journal.unair.ac.id/index.php/MKG Accredited No. 56/DIKTI/Kep/2012 Cover photo purchased from: www.fotolia.com Invoice number: 208879494-206415982 CONTENTS Page Printed by: Airlangga University Press. (RK 237/05.16/AUP-B1E). Kampus C Unair, Mulyorejo Surabaya 60115, Indonesia. Telp. (031) 5992246, 5992247, Telp./Fax. (031) 5992248. E-mail: aup.unair@gmail.com Volume 49, Number 1, March 2016 p-ISSN: 1978-3728 e-ISSN: 2442-9740 1. Methisoprinol as an immunomodulator for treating infectious mononucleosis Maharani Laillyza Apriasari .......................................................................................................... 1–4 2. The difference of saline and sterile water for tetracycline hydrochloride solvents in cementum demineralization Shinta Ferronika, Ahmad Syaify, and Dahlia Herawati ............................................................... 5–9 3. Potency of Stichopus hermanii extract as oral candidiasis treatment on epithelial rat tongue Syamsulina Revianti and Kristanti Parisihni ................................................................................ 10–16 4. The thickness of odontoblast-like cell layer after induced by propolis extract and calcium hydroxide Irfan Dwiandhono, Ruslan Effendy, and Sri Kunarti ................................................................... 17–21 5. The potential of chitosan combined with chicken shank collagen as scaffold on bone defect regeneration process in Rattus norvegicus Fitria Rahmitasari, Retno Pudji Rahayu, and Elly Munadziroh ................................................. 22–26 6. Effects of application of Anadara granosa shell combined with Sardinella longiceps oil on oesteoblast proliferation in bone defect healing process Rima Parwati Sari, Eddy Hermanto, Dinda Divilia, Indira Candra, Wisnu Kuncoro, and Tantri Liswanti .......................................................................................................................... 27–31 7. Salivary neutrophils isolation of severe early childhood caries patients with flow cytometry analysis using magnetic beads and CD177 marker Muhammad Luthfi and Tuti Kusumaningsih ................................................................................ 32–36 8. The effect of combined Moringa oleifera and demineralized freeze-dried bovine bone xenograft on the amount of osteoblast and osteoclast in the healing of tooth extraction socket of Cavia cobaya Rostiny, Eha Djulaeha, Nike Hendrijantini and Agus Pudijanto ............................................... 37–42 9. Effect of mangosteen peel extract combined with demineralized freezed-dried bovine bone xenograft on osteoblast and osteoclast formation in post tooth extraction socket Utari Kresnoadi, Yurike Hadisoesanto, and Harly Prabowo ...................................................... 43–48 10. Beta-defensins-2 expressions in gingival epithelium cells after probiotic Lactobacillus reuteri induction Tuti Kusumaningsih ........................................................................................................................ 49–53 11. Early detection and treatment of speckled leukoplakia Selviana Tampoma and Iwan Hernawan ....................................................................................... 54–58