id	author	title	date	pages	extension	mime	words	sentence	flesch	summary	cache	txt
mkg-10375	Ayuningtyas, Nurina Febriyanti; Mahardika, Grahania Octaviono; Soebadi, Bagus; Permadiati, Adiastuti Endah; Winias, Saka; Hendarti, Hening Tuti; Zain, Rosnah Binti	Hyperplasia of Wistar rat tongue mucosa due to exposure to cigarette side-stream smoke	2019	5	.pdf	application/pdf	3805	236	50	Exposing mice to cigarette smoke for one month, a period considered to constitute long- lasting, chronic exposure, may induce a thickening of the airway epithelium as the body’s defenses against cigarette smoke compounds intensify.21 Against this background, the ratio of K to P1 and of P1 to P2 become insignificant in the course of 28 days because of the ability of the subjects to tolerate cigarette smoke compounds. Since hyperplasia is a reversible condition, further experiments are required to observe any histopathological changes due to extended exposure to sidestream cigarette smoke which support a hypothesis of hyperplasia, characterized by increased proliferation of cells resulting from chronic irritation as a symptom of the onset of carcinogenesis.1,3–5,26 Taken together, it can be concluded that sidestream cigarette smoke exposure induces chronic irritation which may lead to prolonged inflammation and precancerous changes in the oral mucosa of the tongue of a Wistar rat, thereby inducing a response of pathological hyperplasia together with hyperkeratosis.	cache/mkg-10375.pdf	txt/mkg-10375.txt