id	author	title	date	pages	extension	mime	words	sentence	flesch	summary	cache	txt
mkg-1098	Utomo, Haryono	Sensitization of the sphenopalatine ganglion (SPG) by periodontal inflammation: A possible etiology of sinusitis and headache in children	2006	5	.pdf	application/pdf	3636	252	37	Chronic sinusitis is not validated as a cause of headache unless relapsing into an acute phase.4 Migraine and tension-type headache are often confused with true sinus headache because of “similarity in location”.4 On the other hand, migraine may cause autonomic symptoms mimicking sinus problem (i.e. nasal congestion and rhinorrhea) is proposed through the cranial parasympathetic activation by sensitized trigeminal nucleus caudalis (Figure 1).10 hypothesis consists of the crossover mechanism between immunogenic and neurogenic inflammation.3,13 Neurogenic and immunogenic switching can be explained as follows: afferent sensory nerve fibers can be stimulated by histamine and tryptase from degranulated mast cell, proinflammatory cytokines secreted from LPS stimulated macrophages, bradykinin, and nitric oxide (NO). It is a relative common problem in daily practice; in the USA (1995), 13.4–25 million visits to medical practice were related to sinusitis and/or their subsequent effects.1 Most sinusitis are caused by viral infection, and recovered without antibiotic therapy,1 which is coincident to reported studies that a proportion of sinusitis patients had a negative culture.2 Conservative treatments of sinusitis include decongestants, corticosteroids, antibiotics and diathermy.	cache/mkg-1098.pdf	txt/mkg-1098.txt