id	author	title	date	pages	extension	mime	words	sentence	flesch	summary	cache	txt
mkg-1673	Taufiqurrahman, Irham; Harijadi, Achmad; Simanjuntak, Roberto M.; D, Coen Pramono; Istiati, Istiati	The role of ubiquinone supplementation on osteogenesis of nonvascularized autogenous bone graft	2015	5	.pdf	application/pdf	3546	179	49	However, the result of bone healing with autogenous bone grafting depend largely on the integrity of surrounding periosteum since it is the source of mesenchymal stem cells (MSC) and blood vessels which is critical in initial graft healing.1 Periosteum, however, is often defective in patients affliced with extramural tumors in which case the graft failed to grow or incorporate with the surrounding bone.2 Increasing angiogenesis in such cases can be theoretically achieved by supplementing the patients with micronutrient that increase the expression of angiogenic factor, such as vascular endothelial growth factors (VeGF) by osteogenic- committed mesenchymal stem cell. This result was in accordance with in vitro study which demonstrated that mesenchymal stem cell under hypoxic condition showed up-regulation of VeGF and down-regulation of core binding factor-alpha 1 or Cbfa-1/Runx2.9	cache/mkg-1673.pdf	txt/mkg-1673.txt