id	author	title	date	pages	extension	mime	words	sentence	flesch	summary	cache	txt
mkg-805	Supriatno, Supriatno; Yuletnawati, Sartari Entin	Antitumor activity of intratumoral injection of pcDNA3.1-p27Kip1mt followed by in vivo electroporation in a malignant Burkitt's lymphoma cell xenograft	2012	5	.pdf	application/pdf	3515	175	52	Furthermore, the growth of tumors was markedly suppressed by p27Kip1 mt gene transfection compared with transfection of neo. Recently, decreased expression of p27Kip1 has been frequently detected in human cancer.15-17 In addition, loss of p27Kip1 has been associated with disease progression and an unfavorable outcome in several malignancies.18 Furthermore, mice lacking the p27Kip1 gene show an increase in body weight, thymic hypertrophy and hyperplasia of pituitary intermediate lobe adrenocorticotropic hormon cells, adrenal glands and gonadal organ.19 Also, malignant human oral cancer cells transfection with p27Kip1 gene leads to inhibition of proliferation, invasion and metastasis.20,21 In the present study, the antitumor activity of p27Kip1 gene therapy in human malignant Burkitt’s lymphoma (Raji) cell xenografts using pcDNA3.1-p27Kip1 mutant type (mt) and pcDNA3.1 empty vector (neo) with the local application of electric pulses was evaluated.	cache/mkg-805.pdf	txt/mkg-805.txt