id	author	title	date	pages	extension	mime	words	sentence	flesch	summary	cache	txt
mkg-9795	Andriani, Dwi; Pargaputri, Agni Febrina	The effects of Acanthus ilicifolius chloroform extract on TLR-2 expression of macrophages in oral candidiasis	2018	5	.pdf	application/pdf	3479	203	45	The administration of chloroform extract A. ilicifolius 8 mg/ml may increase IL-17 in immunosuppressed subjects suffering from oral candidiasis.17,18 The purpose of this study was to compare the effect of A. ilicifolius chloroform extract and nystatin on TLR-2 expression immunosuppressed models as an alternative medicine derived from natural materials for oral candidiasis. MATERIALS AND METHODS This research represented a true experiment incorporating post test-only control group design. A decrease in the amount of TLR-2 may escalate susceptibility to infection by C. albicans.28 TLR activation, in particular that of TLR-2, can suppress defense immunity against C. albicans through IL-10 induction and T-regulatory cells.29 TLR signals through the MyD88 pathway leading to activation of MAPK and induces the translocation of nuclear factor kappa B to the nucleus which promotes the transcription and synthesis of proinflammatory cytokines.30 In conclusion, A. ilicifolius chloroform extract can increase expression of TLR-2 in oral candidiasis- immunosupressed models.	cache/mkg-9795.pdf	txt/mkg-9795.txt