id	sid	tid	token	lemma	pos
mkg-48486	1	1	184184	184184	NUM
mkg-48486	1	2	dental	dental	ADJ
mkg-48486	1	3	journal	journal	NOUN
mkg-48486	1	4	(	(	PUNCT
mkg-48486	1	5	majalah	majalah	PROPN
mkg-48486	1	6	kedokteran	kedokteran	PROPN
mkg-48486	1	7	gigi	gigi	PROPN
mkg-48486	1	8	)	)	PUNCT
mkg-48486	1	9	2024	2024	NUM
mkg-48486	1	10	september	september	PROPN
mkg-48486	1	11	;	;	PUNCT
mkg-48486	1	12	57(3	57(3	NUM
mkg-48486	1	13	):	):	PUNCT
mkg-48486	1	14	184–188	184–188	NUM
mkg-48486	1	15	original	original	ADJ
mkg-48486	1	16	article	article	NOUN
mkg-48486	1	17	optimizing	optimize	VERB
mkg-48486	1	18	examination	examination	NOUN
mkg-48486	1	19	of	of	ADP
mkg-48486	1	20	methylenetetrahydrofolate	methylenetetrahydrofolate	ADJ
mkg-48486	1	21	reductase	reductase	NOUN
mkg-48486	1	22	gene	gene	NOUN
mkg-48486	1	23	promoter	promoter	NOUN
mkg-48486	1	24	methylation	methylation	NOUN
mkg-48486	1	25	in	in	ADP
mkg-48486	1	26	cleft	cleft	ADJ
mkg-48486	1	27	lip	lip	NOUN
mkg-48486	1	28	with	with	ADP
mkg-48486	1	29	or	or	CCONJ
mkg-48486	1	30	without	without	ADP
mkg-48486	1	31	cleft	cleft	NOUN
mkg-48486	1	32	palate	palate	ADJ
mkg-48486	1	33	non	non	ADJ
mkg-48486	1	34	-	-	ADJ
mkg-48486	1	35	syndromic	syndromic	ADJ
mkg-48486	1	36	patients	patient	NOUN
mkg-48486	1	37	using	use	VERB
mkg-48486	1	38	the	the	DET
mkg-48486	1	39	pyrosequencing	pyrosequencing	NOUN
mkg-48486	1	40	method	method	NOUN
mkg-48486	1	41	ani	ani	X
mkg-48486	1	42	melani	melani	PROPN
mkg-48486	1	43	maskoen1,2	maskoen1,2	PROPN
mkg-48486	1	44	,	,	PUNCT
mkg-48486	1	45	nurul	nurul	PROPN
mkg-48486	1	46	setia	setia	PROPN
mkg-48486	1	47	rahayu3	rahayu3	PROPN
mkg-48486	1	48	,	,	PUNCT
mkg-48486	1	49	saskia	saskia	PROPN
mkg-48486	1	50	lenggogeni	lenggogeni	NOUN
mkg-48486	1	51	nasroen4	nasroen4	PROPN
mkg-48486	2	1	1department	1department	NUM
mkg-48486	2	2	of	of	ADP
mkg-48486	2	3	oral	oral	ADJ
mkg-48486	2	4	biology	biology	NOUN
mkg-48486	2	5	,	,	PUNCT
mkg-48486	2	6	faculty	faculty	NOUN
mkg-48486	2	7	of	of	ADP
mkg-48486	2	8	dentistry	dentistry	NOUN
mkg-48486	2	9	,	,	PUNCT
mkg-48486	2	10	universitas	universita	NOUN
mkg-48486	2	11	jenderal	jenderal	ADJ
mkg-48486	2	12	achmad	achmad	PROPN
mkg-48486	2	13	yani	yani	PROPN
mkg-48486	2	14	,	,	PUNCT
mkg-48486	2	15	cimahi	cimahi	PROPN
mkg-48486	2	16	,	,	PUNCT
mkg-48486	2	17	indonesia	indonesia	PROPN
mkg-48486	2	18	2department	2department	NUM
mkg-48486	2	19	of	of	ADP
mkg-48486	2	20	oral	oral	ADJ
mkg-48486	2	21	biology	biology	NOUN
mkg-48486	2	22	,	,	PUNCT
mkg-48486	2	23	faculty	faculty	NOUN
mkg-48486	2	24	of	of	ADP
mkg-48486	2	25	dentistry	dentistry	NOUN
mkg-48486	2	26	,	,	PUNCT
mkg-48486	2	27	universitas	universita	NOUN
mkg-48486	2	28	padjadjaran	padjadjaran	NOUN
mkg-48486	2	29	,	,	PUNCT
mkg-48486	2	30	bandung	bandung	PROPN
mkg-48486	2	31	,	,	PUNCT
mkg-48486	2	32	indonesia	indonesia	PROPN
mkg-48486	2	33	3molecular	3molecular	NUM
mkg-48486	2	34	genetic	genetic	ADJ
mkg-48486	2	35	laboratory	laboratory	NOUN
mkg-48486	2	36	,	,	PUNCT
mkg-48486	2	37	faculty	faculty	NOUN
mkg-48486	2	38	of	of	ADP
mkg-48486	2	39	medicine	medicine	NOUN
mkg-48486	2	40	,	,	PUNCT
mkg-48486	2	41	universitas	universita	NOUN
mkg-48486	2	42	padjadjaran	padjadjaran	NOUN
mkg-48486	2	43	,	,	PUNCT
mkg-48486	2	44	bandung	bandung	PROPN
mkg-48486	2	45	,	,	PUNCT
mkg-48486	2	46	indonesia	indonesia	PROPN
mkg-48486	2	47	4department	4department	NUM
mkg-48486	2	48	of	of	ADP
mkg-48486	2	49	oral	oral	ADJ
mkg-48486	2	50	and	and	CCONJ
mkg-48486	2	51	maxillofacial	maxillofacial	ADJ
mkg-48486	2	52	surgery	surgery	NOUN
mkg-48486	2	53	,	,	PUNCT
mkg-48486	2	54	faculty	faculty	NOUN
mkg-48486	2	55	of	of	ADP
mkg-48486	2	56	dentistry	dentistry	NOUN
mkg-48486	2	57	,	,	PUNCT
mkg-48486	2	58	universitas	universita	NOUN
mkg-48486	2	59	jenderal	jenderal	ADJ
mkg-48486	2	60	achmad	achmad	PROPN
mkg-48486	2	61	yani	yani	PROPN
mkg-48486	2	62	,	,	PUNCT
mkg-48486	2	63	cimahi	cimahi	PROPN
mkg-48486	2	64	,	,	PUNCT
mkg-48486	2	65	indonesia	indonesia	PROPN
mkg-48486	2	66	abstract	abstract	ADJ
mkg-48486	2	67	background	background	NOUN
mkg-48486	2	68	:	:	PUNCT
mkg-48486	2	69	cleft	cleft	NOUN
mkg-48486	2	70	lip	lip	NOUN
mkg-48486	2	71	with	with	ADP
mkg-48486	2	72	or	or	CCONJ
mkg-48486	2	73	without	without	ADP
mkg-48486	2	74	cleft	cleft	NOUN
mkg-48486	2	75	palate	palate	NOUN
mkg-48486	2	76	(	(	PUNCT
mkg-48486	2	77	cl	cl	NOUN
mkg-48486	2	78	/	/	SYM
mkg-48486	2	79	p	p	NOUN
mkg-48486	2	80	)	)	PUNCT
mkg-48486	2	81	is	be	AUX
mkg-48486	2	82	the	the	DET
mkg-48486	2	83	most	most	ADV
mkg-48486	2	84	common	common	ADJ
mkg-48486	2	85	congenital	congenital	ADJ
mkg-48486	2	86	anomaly	anomaly	NOUN
mkg-48486	2	87	found	find	VERB
mkg-48486	2	88	in	in	ADP
mkg-48486	2	89	indonesia	indonesia	PROPN
mkg-48486	2	90	.	.	PUNCT
mkg-48486	3	1	cl	cl	PROPN
mkg-48486	3	2	/	/	SYM
mkg-48486	3	3	p	p	NOUN
mkg-48486	3	4	is	be	AUX
mkg-48486	3	5	caused	cause	VERB
mkg-48486	3	6	by	by	ADP
mkg-48486	3	7	hereditary	hereditary	ADJ
mkg-48486	3	8	(	(	PUNCT
mkg-48486	3	9	genetic	genetic	ADJ
mkg-48486	3	10	)	)	PUNCT
mkg-48486	3	11	and	and	CCONJ
mkg-48486	3	12	environmental	environmental	ADJ
mkg-48486	3	13	factors	factor	NOUN
mkg-48486	3	14	.	.	PUNCT
mkg-48486	4	1	environmental	environmental	ADJ
mkg-48486	4	2	factors	factor	NOUN
mkg-48486	4	3	can	can	AUX
mkg-48486	4	4	result	result	VERB
mkg-48486	4	5	in	in	ADP
mkg-48486	4	6	methylation	methylation	NOUN
mkg-48486	4	7	in	in	ADP
mkg-48486	4	8	the	the	DET
mkg-48486	4	9	promoter	promoter	NOUN
mkg-48486	4	10	of	of	ADP
mkg-48486	4	11	the	the	DET
mkg-48486	4	12	methylenetetrahydrofolate	methylenetetrahydrofolate	ADJ
mkg-48486	4	13	reductase	reductase	NOUN
mkg-48486	4	14	(	(	PUNCT
mkg-48486	4	15	mthfr	mthfr	NOUN
mkg-48486	4	16	)	)	PUNCT
mkg-48486	4	17	gene	gene	NOUN
mkg-48486	4	18	,	,	PUNCT
mkg-48486	4	19	affecting	affect	VERB
mkg-48486	4	20	its	its	PRON
mkg-48486	4	21	expression	expression	NOUN
mkg-48486	4	22	.	.	PUNCT
mkg-48486	5	1	methylation	methylation	NOUN
mkg-48486	5	2	takes	take	VERB
mkg-48486	5	3	place	place	NOUN
mkg-48486	5	4	at	at	ADP
mkg-48486	5	5	the	the	DET
mkg-48486	5	6	cpg	cpg	NOUN
mkg-48486	5	7	site	site	NOUN
mkg-48486	5	8	found	find	VERB
mkg-48486	5	9	at	at	ADP
mkg-48486	5	10	chromosome	chromosome	NOUN
mkg-48486	5	11	1	1	NUM
mkg-48486	5	12	,	,	PUNCT
mkg-48486	5	13	coordinates	coordinate	NOUN
mkg-48486	5	14	11,805,406–11,806,509	11,805,406–11,806,509	PROPN
mkg-48486	5	15	.	.	PUNCT
mkg-48486	6	1	pyrosequencing	pyrosequence	VERB
mkg-48486	6	2	technology	technology	NOUN
mkg-48486	6	3	can	can	AUX
mkg-48486	6	4	detect	detect	VERB
mkg-48486	6	5	the	the	DET
mkg-48486	6	6	percentage	percentage	NOUN
mkg-48486	6	7	methylation	methylation	NOUN
mkg-48486	6	8	of	of	ADP
mkg-48486	6	9	a	a	DET
mkg-48486	6	10	gene	gene	NOUN
mkg-48486	6	11	quickly	quickly	ADV
mkg-48486	6	12	,	,	PUNCT
mkg-48486	6	13	simply	simply	ADV
mkg-48486	6	14	,	,	PUNCT
mkg-48486	6	15	and	and	CCONJ
mkg-48486	6	16	accurately	accurately	ADV
mkg-48486	6	17	.	.	PUNCT
mkg-48486	7	1	purpose	purpose	NOUN
mkg-48486	7	2	:	:	PUNCT
mkg-48486	7	3	the	the	DET
mkg-48486	7	4	aim	aim	NOUN
mkg-48486	7	5	of	of	ADP
mkg-48486	7	6	the	the	DET
mkg-48486	7	7	study	study	NOUN
mkg-48486	7	8	is	be	AUX
mkg-48486	7	9	to	to	PART
mkg-48486	7	10	optimize	optimize	VERB
mkg-48486	7	11	detection	detection	NOUN
mkg-48486	7	12	of	of	ADP
mkg-48486	7	13	methylation	methylation	NOUN
mkg-48486	7	14	of	of	ADP
mkg-48486	7	15	the	the	DET
mkg-48486	7	16	mthfr	mthfr	NOUN
mkg-48486	7	17	gene	gene	NOUN
mkg-48486	7	18	using	use	VERB
mkg-48486	7	19	the	the	DET
mkg-48486	7	20	pyrosequencing	pyrosequencing	NOUN
mkg-48486	7	21	method	method	NOUN
mkg-48486	7	22	.	.	PUNCT
mkg-48486	8	1	methods	method	NOUN
mkg-48486	8	2	:	:	PUNCT
mkg-48486	8	3	methods	method	NOUN
mkg-48486	8	4	used	use	VERB
mkg-48486	8	5	in	in	ADP
mkg-48486	8	6	this	this	DET
mkg-48486	8	7	study	study	NOUN
mkg-48486	8	8	were	be	AUX
mkg-48486	8	9	dna	dna	PROPN
mkg-48486	8	10	extraction	extraction	NOUN
mkg-48486	8	11	from	from	ADP
mkg-48486	8	12	blood	blood	NOUN
mkg-48486	8	13	,	,	PUNCT
mkg-48486	8	14	dna	dna	NOUN
mkg-48486	8	15	bisulfite	bisulfite	NOUN
mkg-48486	8	16	conversion	conversion	NOUN
mkg-48486	8	17	,	,	PUNCT
mkg-48486	8	18	polymerase	polymerase	NOUN
mkg-48486	8	19	chain	chain	NOUN
mkg-48486	8	20	reaction	reaction	NOUN
mkg-48486	8	21	(	(	PUNCT
mkg-48486	8	22	pcr	pcr	NOUN
mkg-48486	8	23	)	)	PUNCT
mkg-48486	8	24	,	,	PUNCT
mkg-48486	8	25	and	and	CCONJ
mkg-48486	8	26	methylation	methylation	NOUN
mkg-48486	8	27	detection	detection	NOUN
mkg-48486	8	28	using	use	VERB
mkg-48486	8	29	cpg	cpg	NOUN
mkg-48486	8	30	pyrosequencing	pyrosequence	VERB
mkg-48486	8	31	assay	assay	NOUN
mkg-48486	8	32	.	.	PUNCT
mkg-48486	9	1	samples	sample	NOUN
mkg-48486	9	2	were	be	AUX
mkg-48486	9	3	taken	take	VERB
mkg-48486	9	4	from	from	ADP
mkg-48486	9	5	20	20	NUM
mkg-48486	9	6	cl	cl	NOUN
mkg-48486	9	7	/	/	SYM
mkg-48486	9	8	p	p	NOUN
mkg-48486	9	9	patients	patient	NOUN
mkg-48486	9	10	(	(	PUNCT
mkg-48486	9	11	c	c	NOUN
mkg-48486	9	12	)	)	PUNCT
mkg-48486	9	13	and	and	CCONJ
mkg-48486	9	14	44	44	NUM
mkg-48486	9	15	normal	normal	ADJ
mkg-48486	9	16	patients	patient	NOUN
mkg-48486	9	17	(	(	PUNCT
mkg-48486	9	18	n	n	CCONJ
mkg-48486	9	19	)	)	PUNCT
mkg-48486	9	20	.	.	PUNCT
mkg-48486	10	1	results	result	NOUN
mkg-48486	10	2	:	:	PUNCT
mkg-48486	10	3	the	the	DET
mkg-48486	10	4	pyrosequencing	pyrosequencing	NOUN
mkg-48486	10	5	method	method	NOUN
mkg-48486	10	6	was	be	AUX
mkg-48486	10	7	successful	successful	ADJ
mkg-48486	10	8	in	in	ADP
mkg-48486	10	9	detecting	detect	VERB
mkg-48486	10	10	methylation	methylation	NOUN
mkg-48486	10	11	at	at	ADP
mkg-48486	10	12	three	three	NUM
mkg-48486	10	13	mthfr	mthfr	NOUN
mkg-48486	10	14	gene	gene	NOUN
mkg-48486	10	15	sites	site	NOUN
mkg-48486	10	16	at	at	ADP
mkg-48486	10	17	coordinates	coordinate	NOUN
mkg-48486	10	18	11,805,507–11,805,529	11,805,507–11,805,529	NUM
mkg-48486	10	19	.	.	PUNCT
mkg-48486	11	1	the	the	DET
mkg-48486	11	2	methylation	methylation	NOUN
mkg-48486	11	3	level	level	NOUN
mkg-48486	11	4	at	at	ADP
mkg-48486	11	5	the	the	DET
mkg-48486	11	6	third	third	ADJ
mkg-48486	11	7	site	site	NOUN
mkg-48486	11	8	was	be	AUX
mkg-48486	11	9	higher	high	ADJ
mkg-48486	11	10	in	in	ADP
mkg-48486	11	11	group	group	NOUN
mkg-48486	11	12	c	c	PROPN
mkg-48486	11	13	than	than	ADP
mkg-48486	11	14	in	in	ADP
mkg-48486	11	15	group	group	NOUN
mkg-48486	11	16	n	n	CCONJ
mkg-48486	11	17	,	,	PUNCT
mkg-48486	11	18	while	while	SCONJ
mkg-48486	11	19	at	at	ADP
mkg-48486	11	20	the	the	DET
mkg-48486	11	21	first	first	ADJ
mkg-48486	11	22	and	and	CCONJ
mkg-48486	11	23	second	second	ADJ
mkg-48486	11	24	positions	position	NOUN
mkg-48486	11	25	,	,	PUNCT
mkg-48486	11	26	group	group	NOUN
mkg-48486	11	27	c	c	PROPN
mkg-48486	11	28	had	have	VERB
mkg-48486	11	29	a	a	DET
mkg-48486	11	30	lower	low	ADJ
mkg-48486	11	31	methylation	methylation	NOUN
mkg-48486	11	32	level	level	NOUN
mkg-48486	11	33	than	than	ADP
mkg-48486	11	34	group	group	NOUN
mkg-48486	11	35	n.	n.	PROPN
mkg-48486	11	36	in	in	ADP
mkg-48486	11	37	general	general	ADJ
mkg-48486	11	38	,	,	PUNCT
mkg-48486	11	39	the	the	DET
mkg-48486	11	40	percentage	percentage	NOUN
mkg-48486	11	41	of	of	ADP
mkg-48486	11	42	methylation	methylation	NOUN
mkg-48486	11	43	for	for	ADP
mkg-48486	11	44	both	both	DET
mkg-48486	11	45	groups	group	NOUN
mkg-48486	11	46	was	be	AUX
mkg-48486	11	47	low	low	ADJ
mkg-48486	11	48	or	or	CCONJ
mkg-48486	11	49	hypomethylated	hypomethylate	VERB
mkg-48486	11	50	(	(	PUNCT
mkg-48486	11	51	less	less	ADJ
mkg-48486	11	52	than	than	ADP
mkg-48486	11	53	5	5	NUM
mkg-48486	11	54	%	%	NOUN
mkg-48486	11	55	)	)	PUNCT
mkg-48486	11	56	.	.	PUNCT
mkg-48486	12	1	conclusion	conclusion	NOUN
mkg-48486	12	2	:	:	PUNCT
mkg-48486	12	3	the	the	DET
mkg-48486	12	4	pyrosequencing	pyrosequencing	NOUN
mkg-48486	12	5	method	method	NOUN
mkg-48486	12	6	can	can	AUX
mkg-48486	12	7	be	be	AUX
mkg-48486	12	8	used	use	VERB
mkg-48486	12	9	to	to	PART
mkg-48486	12	10	determine	determine	VERB
mkg-48486	12	11	methylation	methylation	NOUN
mkg-48486	12	12	levels	level	NOUN
mkg-48486	12	13	in	in	ADP
mkg-48486	12	14	the	the	DET
mkg-48486	12	15	mthfr	mthfr	NOUN
mkg-48486	12	16	gene	gene	NOUN
mkg-48486	12	17	with	with	ADP
mkg-48486	12	18	the	the	DET
mkg-48486	12	19	results	result	NOUN
mkg-48486	12	20	presented	present	VERB
mkg-48486	12	21	as	as	ADP
mkg-48486	12	22	percentages	percentage	NOUN
mkg-48486	12	23	(	(	PUNCT
mkg-48486	12	24	quantitative	quantitative	ADJ
mkg-48486	12	25	data	datum	NOUN
mkg-48486	12	26	)	)	PUNCT
mkg-48486	12	27	.	.	PUNCT
mkg-48486	13	1	hypomethylation	hypomethylation	NOUN
mkg-48486	13	2	occurs	occur	VERB
mkg-48486	13	3	in	in	ADP
mkg-48486	13	4	groups	group	NOUN
mkg-48486	13	5	c	c	PROPN
mkg-48486	13	6	and	and	CCONJ
mkg-48486	13	7	n	n	PROPN
mkg-48486	13	8	at	at	ADP
mkg-48486	13	9	the	the	DET
mkg-48486	13	10	coordinates	coordinate	NOUN
mkg-48486	13	11	11,805,507–11,805,529	11,805,507–11,805,529	NUM
mkg-48486	13	12	of	of	ADP
mkg-48486	13	13	the	the	DET
mkg-48486	13	14	mthfr	mthfr	PROPN
mkg-48486	13	15	gene	gene	NOUN
mkg-48486	13	16	promoter	promoter	NOUN
mkg-48486	13	17	.	.	PUNCT
mkg-48486	14	1	keywords	keyword	NOUN
mkg-48486	14	2	:	:	PUNCT
mkg-48486	14	3	cleft	cleft	NOUN
mkg-48486	14	4	lip	lip	NOUN
mkg-48486	14	5	;	;	PUNCT
mkg-48486	14	6	cleft	cleft	NOUN
mkg-48486	14	7	palate	palate	NOUN
mkg-48486	14	8	;	;	PUNCT
mkg-48486	14	9	methylation	methylation	NOUN
mkg-48486	14	10	;	;	PUNCT
mkg-48486	14	11	mthfr	mthfr	NOUN
mkg-48486	14	12	;	;	PUNCT
mkg-48486	14	13	pyrosequencing	pyrosequence	VERB
mkg-48486	14	14	article	article	NOUN
mkg-48486	14	15	history	history	NOUN
mkg-48486	14	16	:	:	PUNCT
mkg-48486	14	17	received	receive	VERB
mkg-48486	14	18	8	8	NUM
mkg-48486	14	19	august	august	PROPN
mkg-48486	14	20	2023	2023	NUM
mkg-48486	14	21	;	;	PUNCT
mkg-48486	14	22	revised	revise	VERB
mkg-48486	14	23	31	31	NUM
mkg-48486	14	24	october	october	PROPN
mkg-48486	14	25	2023	2023	NUM
mkg-48486	14	26	;	;	PUNCT
mkg-48486	14	27	accepted	accept	VERB
mkg-48486	14	28	18	18	NUM
mkg-48486	14	29	january	january	NOUN
mkg-48486	14	30	2024	2024	NUM
mkg-48486	14	31	;	;	PUNCT
mkg-48486	14	32	published	publish	VERB
mkg-48486	14	33	1	1	NUM
mkg-48486	14	34	september	september	PROPN
mkg-48486	14	35	2024	2024	NUM
mkg-48486	14	36	correspondence	correspondence	NOUN
mkg-48486	14	37	:	:	PUNCT
mkg-48486	14	38	nurul	nurul	PROPN
mkg-48486	14	39	setia	setia	PROPN
mkg-48486	14	40	rahayu	rahayu	PROPN
mkg-48486	14	41	,	,	PUNCT
mkg-48486	14	42	molecular	molecular	ADJ
mkg-48486	14	43	genetic	genetic	ADJ
mkg-48486	14	44	laboratory	laboratory	NOUN
mkg-48486	14	45	,	,	PUNCT
mkg-48486	14	46	faculty	faculty	NOUN
mkg-48486	14	47	of	of	ADP
mkg-48486	14	48	medicine	medicine	NOUN
mkg-48486	14	49	,	,	PUNCT
mkg-48486	14	50	universitas	universita	NOUN
mkg-48486	14	51	padjadjaran	padjadjaran	NOUN
mkg-48486	14	52	,	,	PUNCT
mkg-48486	15	1	jl	jl	PROPN
mkg-48486	15	2	.	.	PROPN
mkg-48486	15	3	eyckman	eyckman	PROPN
mkg-48486	15	4	38	38	NUM
mkg-48486	15	5	bandung	bandung	NOUN
mkg-48486	15	6	,	,	PUNCT
mkg-48486	15	7	40161	40161	NUM
mkg-48486	15	8	,	,	PUNCT
mkg-48486	15	9	indonesia	indonesia	PROPN
mkg-48486	15	10	.	.	PUNCT
mkg-48486	15	11	email	email	NOUN
mkg-48486	15	12	:	:	PUNCT
mkg-48486	15	13	nurul.setia@unpad.ac.id	nurul.setia@unpad.ac.id	NUM
mkg-48486	15	14	introduction	introduction	NOUN
mkg-48486	15	15	cleft	cleft	NOUN
mkg-48486	15	16	lip	lip	NOUN
mkg-48486	15	17	with	with	ADP
mkg-48486	15	18	or	or	CCONJ
mkg-48486	15	19	without	without	ADP
mkg-48486	15	20	cleft	cleft	NOUN
mkg-48486	15	21	palate	palate	NOUN
mkg-48486	15	22	(	(	PUNCT
mkg-48486	15	23	cl	cl	NOUN
mkg-48486	15	24	/	/	SYM
mkg-48486	15	25	p	p	NOUN
mkg-48486	15	26	)	)	PUNCT
mkg-48486	15	27	is	be	AUX
mkg-48486	15	28	a	a	DET
mkg-48486	15	29	birth	birth	NOUN
mkg-48486	15	30	defect	defect	NOUN
mkg-48486	15	31	that	that	PRON
mkg-48486	15	32	affects	affect	VERB
mkg-48486	15	33	the	the	DET
mkg-48486	15	34	upper	upper	ADJ
mkg-48486	15	35	lip	lip	NOUN
mkg-48486	15	36	and	and	CCONJ
mkg-48486	15	37	palate	palate	VERB
mkg-48486	15	38	.	.	PUNCT
mkg-48486	16	1	oral	oral	ADJ
mkg-48486	16	2	-	-	PUNCT
mkg-48486	16	3	facial	facial	ADJ
mkg-48486	16	4	cleft	cleft	NOUN
mkg-48486	16	5	,	,	PUNCT
mkg-48486	16	6	especially	especially	ADV
mkg-48486	16	7	cl	cl	NOUN
mkg-48486	16	8	/	/	SYM
mkg-48486	16	9	p	p	NOUN
mkg-48486	16	10	,	,	PUNCT
mkg-48486	16	11	is	be	AUX
mkg-48486	16	12	the	the	DET
mkg-48486	16	13	most	most	ADV
mkg-48486	16	14	common	common	ADJ
mkg-48486	16	15	craniofacial	craniofacial	ADJ
mkg-48486	16	16	deformity	deformity	NOUN
mkg-48486	16	17	,	,	PUNCT
mkg-48486	16	18	with	with	ADP
mkg-48486	16	19	worldwide	worldwide	ADJ
mkg-48486	16	20	prevalence	prevalence	NOUN
mkg-48486	16	21	reaching	reach	VERB
mkg-48486	16	22	1	1	NUM
mkg-48486	16	23	in	in	ADP
mkg-48486	16	24	700	700	NUM
mkg-48486	16	25	to	to	PART
mkg-48486	16	26	1000	1000	NUM
mkg-48486	16	27	live	live	ADV
mkg-48486	16	28	births.1	births.1	PROPN
mkg-48486	16	29	cl	cl	NOUN
mkg-48486	16	30	/	/	SYM
mkg-48486	16	31	p	p	NOUN
mkg-48486	16	32	is	be	AUX
mkg-48486	16	33	divided	divide	VERB
mkg-48486	16	34	into	into	ADP
mkg-48486	16	35	two	two	NUM
mkg-48486	16	36	categories	category	NOUN
mkg-48486	16	37	,	,	PUNCT
mkg-48486	16	38	namely	namely	ADV
mkg-48486	16	39	syndromic	syndromic	ADJ
mkg-48486	16	40	and	and	CCONJ
mkg-48486	16	41	non	non	ADJ
mkg-48486	16	42	-	-	ADJ
mkg-48486	16	43	syndromic	syndromic	ADJ
mkg-48486	16	44	(	(	PUNCT
mkg-48486	16	45	ns	ns	NUM
mkg-48486	16	46	)	)	PUNCT
mkg-48486	16	47	.	.	PUNCT
mkg-48486	17	1	in	in	ADP
mkg-48486	17	2	indonesia	indonesia	PROPN
mkg-48486	17	3	,	,	PUNCT
mkg-48486	17	4	the	the	DET
mkg-48486	17	5	birth	birth	NOUN
mkg-48486	17	6	of	of	ADP
mkg-48486	17	7	babies	baby	NOUN
mkg-48486	17	8	with	with	ADP
mkg-48486	17	9	cl	cl	NOUN
mkg-48486	17	10	/	/	SYM
mkg-48486	17	11	p	p	NOUN
mkg-48486	17	12	ns	ns	NUM
mkg-48486	17	13	abnormalities	abnormality	NOUN
mkg-48486	17	14	is	be	AUX
mkg-48486	17	15	quite	quite	ADV
mkg-48486	17	16	high	high	ADJ
mkg-48486	17	17	,	,	PUNCT
mkg-48486	17	18	namely	namely	ADV
mkg-48486	17	19	around	around	ADP
mkg-48486	17	20	1.7/1000	1.7/1000	NUM
mkg-48486	17	21	live	live	ADJ
mkg-48486	17	22	births	birth	NOUN
mkg-48486	17	23	,	,	PUNCT
mkg-48486	17	24	and	and	CCONJ
mkg-48486	17	25	in	in	ADP
mkg-48486	17	26	hasan	hasan	PROPN
mkg-48486	17	27	sadikin	sadikin	PROPN
mkg-48486	17	28	hospital	hospital	PROPN
mkg-48486	17	29	in	in	ADP
mkg-48486	17	30	bandung	bandung	PROPN
mkg-48486	17	31	the	the	DET
mkg-48486	17	32	incidence	incidence	NOUN
mkg-48486	17	33	is	be	AUX
mkg-48486	17	34	around	around	ADV
mkg-48486	17	35	1.47/1000	1.47/1000	NUM
mkg-48486	17	36	live	live	ADV
mkg-48486	17	37	births.2	births.2	PROPN
mkg-48486	17	38	in	in	ADP
mkg-48486	17	39	asia	asia	PROPN
mkg-48486	17	40	,	,	PUNCT
mkg-48486	17	41	the	the	DET
mkg-48486	17	42	prevalence	prevalence	NOUN
mkg-48486	17	43	of	of	ADP
mkg-48486	17	44	babies	baby	NOUN
mkg-48486	17	45	born	bear	VERB
mkg-48486	17	46	with	with	ADP
mkg-48486	17	47	cl	cl	NOUN
mkg-48486	17	48	/	/	SYM
mkg-48486	17	49	p	p	NOUN
mkg-48486	17	50	ns	ns	ADJ
mkg-48486	17	51	conditions	condition	NOUN
mkg-48486	17	52	reaches	reach	VERB
mkg-48486	17	53	1	1	NUM
mkg-48486	17	54	per	per	ADP
mkg-48486	17	55	500	500	NUM
mkg-48486	17	56	births	birth	NOUN
mkg-48486	17	57	,	,	PUNCT
mkg-48486	17	58	the	the	DET
mkg-48486	17	59	prevalence	prevalence	NOUN
mkg-48486	17	60	is	be	AUX
mkg-48486	17	61	highest	high	ADJ
mkg-48486	17	62	in	in	ADP
mkg-48486	17	63	asia	asia	PROPN
mkg-48486	17	64	,	,	PUNCT
mkg-48486	17	65	followed	follow	VERB
mkg-48486	17	66	by	by	ADP
mkg-48486	17	67	europe	europe	PROPN
mkg-48486	17	68	and	and	CCONJ
mkg-48486	17	69	africa.3	africa.3	PROPN
mkg-48486	17	70	in	in	ADP
mkg-48486	17	71	indonesia	indonesia	PROPN
mkg-48486	17	72	,	,	PUNCT
mkg-48486	17	73	it	it	PRON
mkg-48486	17	74	is	be	AUX
mkg-48486	17	75	estimated	estimate	VERB
mkg-48486	17	76	that	that	SCONJ
mkg-48486	17	77	7,500	7,500	NUM
mkg-48486	17	78	children	child	NOUN
mkg-48486	17	79	suffer	suffer	VERB
mkg-48486	17	80	from	from	ADP
mkg-48486	17	81	cleft	cleft	ADJ
mkg-48486	17	82	lip	lip	NOUN
mkg-48486	17	83	or	or	CCONJ
mkg-48486	17	84	cleft	cleave	VERB
mkg-48486	17	85	palate.4	palate.4	NOUN
mkg-48486	17	86	in	in	ADP
mkg-48486	17	87	the	the	DET
mkg-48486	17	88	west	west	PROPN
mkg-48486	17	89	java	java	PROPN
mkg-48486	17	90	area	area	PROPN
mkg-48486	17	91	,	,	PUNCT
mkg-48486	17	92	there	there	PRON
mkg-48486	17	93	were	be	VERB
mkg-48486	17	94	1,087	1,087	NUM
mkg-48486	17	95	cl	cl	NOUN
mkg-48486	17	96	/	/	SYM
mkg-48486	17	97	p	p	NOUN
mkg-48486	17	98	ns	ns	NUM
mkg-48486	17	99	patients	patient	NOUN
mkg-48486	17	100	from	from	ADP
mkg-48486	17	101	january	january	PROPN
mkg-48486	17	102	2016	2016	NUM
mkg-48486	17	103	to	to	ADP
mkg-48486	17	104	december	december	PROPN
mkg-48486	17	105	2019.5,6	2019.5,6	NUM
mkg-48486	17	106	cl	cl	NOUN
mkg-48486	17	107	/	/	SYM
mkg-48486	17	108	p	p	PRON
mkg-48486	17	109	is	be	AUX
mkg-48486	17	110	a	a	DET
mkg-48486	17	111	hereditary	hereditary	ADJ
mkg-48486	17	112	disease	disease	NOUN
mkg-48486	17	113	caused	cause	VERB
mkg-48486	17	114	by	by	ADP
mkg-48486	17	115	a	a	DET
mkg-48486	17	116	gene	gene	NOUN
mkg-48486	17	117	mutation	mutation	NOUN
mkg-48486	17	118	.	.	PUNCT
mkg-48486	18	1	it	it	PRON
mkg-48486	18	2	can	can	AUX
mkg-48486	18	3	also	also	ADV
mkg-48486	18	4	be	be	AUX
mkg-48486	18	5	caused	cause	VERB
mkg-48486	18	6	by	by	ADP
mkg-48486	18	7	environmental	environmental	ADJ
mkg-48486	18	8	factors	factor	NOUN
mkg-48486	18	9	such	such	ADJ
mkg-48486	18	10	as	as	ADP
mkg-48486	18	11	viral	viral	ADJ
mkg-48486	18	12	and	and	CCONJ
mkg-48486	18	13	microorganism	microorganism	NOUN
mkg-48486	18	14	infection	infection	NOUN
mkg-48486	18	15	in	in	ADP
mkg-48486	18	16	early	early	ADJ
mkg-48486	18	17	pregnancy	pregnancy	NOUN
mkg-48486	18	18	or	or	CCONJ
mkg-48486	18	19	exposure	exposure	NOUN
mkg-48486	18	20	to	to	ADP
mkg-48486	18	21	hazardous	hazardous	ADJ
mkg-48486	18	22	chemicals	chemical	NOUN
mkg-48486	18	23	(	(	PUNCT
mkg-48486	18	24	mutagenic	mutagenic	ADJ
mkg-48486	18	25	causes	cause	NOUN
mkg-48486	18	26	)	)	PUNCT
mkg-48486	18	27	.	.	PUNCT
mkg-48486	19	1	the	the	DET
mkg-48486	19	2	influence	influence	NOUN
mkg-48486	19	3	of	of	ADP
mkg-48486	19	4	environmental	environmental	ADJ
mkg-48486	19	5	factors	factor	NOUN
mkg-48486	19	6	and	and	CCONJ
mkg-48486	19	7	their	their	PRON
mkg-48486	19	8	interaction	interaction	NOUN
mkg-48486	19	9	with	with	ADP
mkg-48486	19	10	various	various	ADJ
mkg-48486	19	11	genes	gene	NOUN
mkg-48486	19	12	involved	involve	VERB
mkg-48486	19	13	in	in	ADP
mkg-48486	19	14	embryogenesis	embryogenesis	NOUN
mkg-48486	19	15	also	also	ADV
mkg-48486	19	16	play	play	VERB
mkg-48486	19	17	an	an	DET
mkg-48486	19	18	important	important	ADJ
mkg-48486	19	19	role	role	NOUN
mkg-48486	19	20	in	in	ADP
mkg-48486	19	21	the	the	DET
mkg-48486	19	22	development	development	NOUN
mkg-48486	19	23	of	of	ADP
mkg-48486	19	24	cl	cl	NOUN
mkg-48486	19	25	/	/	SYM
mkg-48486	19	26	p.7	p.7	NOUN
mkg-48486	19	27	previous	previous	ADJ
mkg-48486	19	28	studies	study	NOUN
mkg-48486	19	29	show	show	VERB
mkg-48486	19	30	that	that	SCONJ
mkg-48486	19	31	mutations	mutation	NOUN
mkg-48486	19	32	in	in	ADP
mkg-48486	19	33	the	the	DET
mkg-48486	19	34	methylenetetrahydrofolate	methylenetetrahydrofolate	ADJ
mkg-48486	19	35	reductase	reductase	NOUN
mkg-48486	19	36	copyright	copyright	NOUN
mkg-48486	19	37	©	©	PROPN
mkg-48486	19	38	2024	2024	NUM
mkg-48486	19	39	dental	dental	ADJ
mkg-48486	19	40	journal	journal	NOUN
mkg-48486	19	41	(	(	PUNCT
mkg-48486	19	42	majalah	majalah	PROPN
mkg-48486	19	43	kedokteran	kedokteran	PROPN
mkg-48486	19	44	gigi	gigi	PROPN
mkg-48486	19	45	)	)	PUNCT
mkg-48486	19	46	p	p	X
mkg-48486	19	47	-	-	PUNCT
mkg-48486	19	48	issn	issn	NOUN
mkg-48486	19	49	:	:	PUNCT
mkg-48486	19	50	1978	1978	NUM
mkg-48486	19	51	-	-	SYM
mkg-48486	19	52	3728	3728	NUM
mkg-48486	19	53	;	;	PUNCT
mkg-48486	19	54	e	e	X
mkg-48486	19	55	-	-	PUNCT
mkg-48486	19	56	issn	issn	ADJ
mkg-48486	19	57	:	:	PUNCT
mkg-48486	19	58	2442	2442	NUM
mkg-48486	19	59	-	-	SYM
mkg-48486	19	60	9740	9740	NUM
mkg-48486	19	61	.	.	PUNCT
mkg-48486	20	1	accredited	accredit	VERB
mkg-48486	20	2	no	no	INTJ
mkg-48486	20	3	.	.	PROPN
mkg-48486	21	1	158	158	NUM
mkg-48486	21	2	/	/	SYM
mkg-48486	21	3	e	e	NOUN
mkg-48486	21	4	/	/	SYM
mkg-48486	21	5	kpt/2021	kpt/2021	NOUN
mkg-48486	21	6	.	.	PUNCT
mkg-48486	22	1	open	open	ADJ
mkg-48486	22	2	access	access	NOUN
mkg-48486	22	3	under	under	ADP
mkg-48486	22	4	cc	cc	NOUN
mkg-48486	22	5	-	-	PUNCT
mkg-48486	22	6	by	by	ADP
mkg-48486	22	7	-	-	PUNCT
mkg-48486	22	8	sa	sa	NOUN
mkg-48486	22	9	license	license	NOUN
mkg-48486	22	10	.	.	PUNCT
mkg-48486	23	1	available	available	ADJ
mkg-48486	23	2	at	at	ADP
mkg-48486	23	3	https://e-journal.unair.ac.id/mkg/index	https://e-journal.unair.ac.id/mkg/index	NOUN
mkg-48486	23	4	doi	doi	NOUN
mkg-48486	23	5	:	:	PUNCT
mkg-48486	23	6	10.20473	10.20473	NUM
mkg-48486	23	7	/	/	SYM
mkg-48486	23	8	j.djmkg.v57.i3.p184–188	j.djmkg.v57.i3.p184–188	NOUN
mkg-48486	23	9	mailto:nurul.setia@unpad.ac.id	mailto:nurul.setia@unpad.ac.id	NUM
mkg-48486	23	10	https://e-journal.unair.ac.id/mkg/index	https://e-journal.unair.ac.id/mkg/index	NOUN
mkg-48486	23	11	https://doi.org/10.20473/j.djmkg.v57.i3.p184-188	https://doi.org/10.20473/j.djmkg.v57.i3.p184-188	VERB
mkg-48486	23	12	185	185	NUM
mkg-48486	23	13	maskoen	maskoen	NOUN
mkg-48486	23	14	et	et	PROPN
mkg-48486	23	15	al	al	PROPN
mkg-48486	23	16	.	.	PROPN
mkg-48486	23	17	dent	dent	PROPN
mkg-48486	23	18	.	.	PUNCT
mkg-48486	24	1	j.	j.	PROPN
mkg-48486	24	2	(	(	PUNCT
mkg-48486	24	3	majalah	majalah	PROPN
mkg-48486	24	4	kedokteran	kedokteran	PROPN
mkg-48486	24	5	gigi	gigi	PROPN
mkg-48486	24	6	)	)	PUNCT
mkg-48486	24	7	2024	2024	NUM
mkg-48486	24	8	september	september	PROPN
mkg-48486	24	9	;	;	PUNCT
mkg-48486	24	10	57(3	57(3	NUM
mkg-48486	24	11	):	):	PUNCT
mkg-48486	24	12	184–188	184–188	NUM
mkg-48486	24	13	(	(	PUNCT
mkg-48486	24	14	mthfr	mthfr	NOUN
mkg-48486	24	15	)	)	PUNCT
mkg-48486	24	16	allele	allele	NOUN
mkg-48486	24	17	677	677	NUM
mkg-48486	24	18	t	t	NOUN
mkg-48486	24	19	are	be	AUX
mkg-48486	24	20	the	the	DET
mkg-48486	24	21	most	most	ADV
mkg-48486	24	22	common	common	ADJ
mkg-48486	24	23	polymorphisms	polymorphism	NOUN
mkg-48486	24	24	found	find	VERB
mkg-48486	24	25	in	in	ADP
mkg-48486	24	26	cl	cl	NOUN
mkg-48486	24	27	/	/	SYM
mkg-48486	24	28	p	p	NOUN
mkg-48486	24	29	patients	patient	NOUN
mkg-48486	24	30	.	.	PUNCT
mkg-48486	25	1	the	the	DET
mkg-48486	25	2	mthfr	mthfr	PROPN
mkg-48486	25	3	gene	gene	NOUN
mkg-48486	25	4	is	be	AUX
mkg-48486	25	5	a	a	DET
mkg-48486	25	6	genetic	genetic	ADJ
mkg-48486	25	7	component	component	NOUN
mkg-48486	25	8	involved	involve	VERB
mkg-48486	25	9	in	in	ADP
mkg-48486	25	10	the	the	DET
mkg-48486	25	11	folate	folate	NOUN
mkg-48486	25	12	cycle	cycle	NOUN
mkg-48486	25	13	.	.	PUNCT
mkg-48486	26	1	this	this	DET
mkg-48486	26	2	gene	gene	NOUN
mkg-48486	26	3	is	be	AUX
mkg-48486	26	4	responsible	responsible	ADJ
mkg-48486	26	5	for	for	ADP
mkg-48486	26	6	the	the	DET
mkg-48486	26	7	process	process	NOUN
mkg-48486	26	8	of	of	ADP
mkg-48486	26	9	converting	convert	VERB
mkg-48486	26	10	folate	folate	NOUN
mkg-48486	26	11	from	from	ADP
mkg-48486	26	12	the	the	DET
mkg-48486	26	13	food	food	NOUN
mkg-48486	26	14	or	or	CCONJ
mkg-48486	26	15	supplements	supplement	NOUN
mkg-48486	26	16	we	we	PRON
mkg-48486	26	17	consume	consume	VERB
mkg-48486	26	18	daily	daily	ADV
mkg-48486	26	19	into	into	ADP
mkg-48486	26	20	the	the	DET
mkg-48486	26	21	active	active	ADJ
mkg-48486	26	22	form	form	NOUN
mkg-48486	26	23	of	of	ADP
mkg-48486	26	24	folate	folate	NOUN
mkg-48486	26	25	used	use	VERB
mkg-48486	26	26	by	by	ADP
mkg-48486	26	27	the	the	DET
mkg-48486	26	28	body	body	NOUN
mkg-48486	26	29	as	as	ADP
mkg-48486	26	30	an	an	DET
mkg-48486	26	31	essential	essential	ADJ
mkg-48486	26	32	nutrient.8	nutrient.8	PROPN
mkg-48486	26	33	dna	dna	PROPN
mkg-48486	26	34	methylation	methylation	NOUN
mkg-48486	26	35	is	be	AUX
mkg-48486	26	36	the	the	DET
mkg-48486	26	37	most	most	ADV
mkg-48486	26	38	common	common	ADJ
mkg-48486	26	39	epigenetic	epigenetic	ADJ
mkg-48486	26	40	process	process	NOUN
mkg-48486	26	41	and	and	CCONJ
mkg-48486	26	42	is	be	AUX
mkg-48486	26	43	one	one	NUM
mkg-48486	26	44	of	of	ADP
mkg-48486	26	45	the	the	DET
mkg-48486	26	46	mechanisms	mechanism	NOUN
mkg-48486	26	47	of	of	ADP
mkg-48486	26	48	epigenetic	epigenetic	ADJ
mkg-48486	26	49	control	control	NOUN
mkg-48486	26	50	over	over	ADP
mkg-48486	26	51	hereditary	hereditary	ADJ
mkg-48486	26	52	(	(	PUNCT
mkg-48486	26	53	inherited	inherited	ADJ
mkg-48486	26	54	)	)	PUNCT
mkg-48486	26	55	gene	gene	NOUN
mkg-48486	26	56	expression	expression	NOUN
mkg-48486	26	57	,	,	PUNCT
mkg-48486	26	58	but	but	CCONJ
mkg-48486	26	59	it	it	PRON
mkg-48486	26	60	does	do	AUX
mkg-48486	26	61	not	not	PART
mkg-48486	26	62	change	change	VERB
mkg-48486	26	63	the	the	DET
mkg-48486	26	64	base	base	NOUN
mkg-48486	26	65	arrangement	arrangement	NOUN
mkg-48486	26	66	of	of	ADP
mkg-48486	26	67	dna	dna	PROPN
mkg-48486	26	68	.	.	PUNCT
mkg-48486	27	1	epigenetic	epigenetic	ADJ
mkg-48486	27	2	changes	change	NOUN
mkg-48486	27	3	can	can	AUX
mkg-48486	27	4	affect	affect	VERB
mkg-48486	27	5	gene	gene	NOUN
mkg-48486	27	6	expression	expression	NOUN
mkg-48486	27	7	through	through	ADP
mkg-48486	27	8	the	the	DET
mkg-48486	27	9	addition	addition	NOUN
mkg-48486	27	10	of	of	ADP
mkg-48486	27	11	a	a	DET
mkg-48486	27	12	methyl	methyl	NOUN
mkg-48486	27	13	group	group	NOUN
mkg-48486	27	14	at	at	ADP
mkg-48486	27	15	the	the	DET
mkg-48486	27	16	fifth	fifth	ADJ
mkg-48486	27	17	carbon	carbon	NOUN
mkg-48486	27	18	position	position	NOUN
mkg-48486	27	19	of	of	ADP
mkg-48486	27	20	cytosine	cytosine	NOUN
mkg-48486	27	21	on	on	ADP
mkg-48486	27	22	cpg	cpg	PROPN
mkg-48486	27	23	dinucleotides	dinucleotide	VERB
mkg-48486	27	24	.	.	PUNCT
mkg-48486	28	1	these	these	DET
mkg-48486	28	2	cpg	cpg	NOUN
mkg-48486	28	3	locations	location	NOUN
mkg-48486	28	4	are	be	AUX
mkg-48486	28	5	always	always	ADV
mkg-48486	28	6	clustered	cluster	VERB
mkg-48486	28	7	to	to	PART
mkg-48486	28	8	form	form	VERB
mkg-48486	28	9	a	a	DET
mkg-48486	28	10	kind	kind	NOUN
mkg-48486	28	11	of	of	ADP
mkg-48486	28	12	island	island	NOUN
mkg-48486	28	13	,	,	PUNCT
mkg-48486	28	14	known	know	VERB
mkg-48486	28	15	as	as	ADP
mkg-48486	28	16	a	a	DET
mkg-48486	28	17	cpg	cpg	NOUN
mkg-48486	28	18	island	island	NOUN
mkg-48486	28	19	,	,	PUNCT
mkg-48486	28	20	that	that	PRON
mkg-48486	28	21	contains	contain	VERB
mkg-48486	28	22	between	between	ADP
mkg-48486	28	23	200	200	NUM
mkg-48486	28	24	bases	basis	NOUN
mkg-48486	28	25	and	and	CCONJ
mkg-48486	28	26	several	several	ADJ
mkg-48486	28	27	kilobases	kilobase	NOUN
mkg-48486	28	28	.	.	PUNCT
mkg-48486	29	1	cpg	cpg	NOUN
mkg-48486	29	2	islands	island	NOUN
mkg-48486	29	3	are	be	AUX
mkg-48486	29	4	predominantly	predominantly	ADV
mkg-48486	29	5	found	find	VERB
mkg-48486	29	6	in	in	ADP
mkg-48486	29	7	the	the	DET
mkg-48486	29	8	promoter	promoter	NOUN
mkg-48486	29	9	region	region	NOUN
mkg-48486	29	10	of	of	ADP
mkg-48486	29	11	a	a	DET
mkg-48486	29	12	gene.9	gene.9	NOUN
mkg-48486	29	13	the	the	DET
mkg-48486	29	14	methylation	methylation	NOUN
mkg-48486	29	15	of	of	ADP
mkg-48486	29	16	nitrogen	nitrogen	NOUN
mkg-48486	29	17	bases	basis	NOUN
mkg-48486	29	18	is	be	AUX
mkg-48486	29	19	higher	high	ADJ
mkg-48486	29	20	in	in	ADP
mkg-48486	29	21	dna	dna	PROPN
mkg-48486	29	22	segments	segment	NOUN
mkg-48486	29	23	that	that	PRON
mkg-48486	29	24	are	be	AUX
mkg-48486	29	25	rich	rich	ADJ
mkg-48486	29	26	in	in	ADP
mkg-48486	29	27	cytosine	cytosine	NOUN
mkg-48486	29	28	and	and	CCONJ
mkg-48486	29	29	guanine	guanine	NOUN
mkg-48486	29	30	bases	basis	NOUN
mkg-48486	29	31	,	,	PUNCT
mkg-48486	29	32	which	which	PRON
mkg-48486	29	33	bind	bind	VERB
mkg-48486	29	34	via	via	ADP
mkg-48486	29	35	phosphodiester	phosphodiester	ADJ
mkg-48486	29	36	bonds	bond	NOUN
mkg-48486	29	37	(	(	PUNCT
mkg-48486	29	38	cpg	cpg	NOUN
mkg-48486	29	39	islands	island	NOUN
mkg-48486	29	40	)	)	PUNCT
mkg-48486	29	41	.	.	PUNCT
mkg-48486	30	1	environmental	environmental	ADJ
mkg-48486	30	2	factors	factor	NOUN
mkg-48486	30	3	can	can	AUX
mkg-48486	30	4	affect	affect	VERB
mkg-48486	30	5	the	the	DET
mkg-48486	30	6	expression	expression	NOUN
mkg-48486	30	7	of	of	ADP
mkg-48486	30	8	a	a	DET
mkg-48486	30	9	gene	gene	NOUN
mkg-48486	30	10	by	by	ADP
mkg-48486	30	11	causing	cause	VERB
mkg-48486	30	12	the	the	DET
mkg-48486	30	13	addition	addition	NOUN
mkg-48486	30	14	of	of	ADP
mkg-48486	30	15	methyl	methyl	NOUN
mkg-48486	30	16	groups	group	NOUN
mkg-48486	30	17	to	to	ADP
mkg-48486	30	18	the	the	DET
mkg-48486	30	19	promoter	promoter	NOUN
mkg-48486	30	20	region	region	NOUN
mkg-48486	30	21	of	of	ADP
mkg-48486	30	22	a	a	DET
mkg-48486	30	23	gene	gene	NOUN
mkg-48486	30	24	.	.	PUNCT
mkg-48486	31	1	excessive	excessive	ADJ
mkg-48486	31	2	methylation	methylation	NOUN
mkg-48486	31	3	levels	level	NOUN
mkg-48486	31	4	will	will	AUX
mkg-48486	31	5	cause	cause	VERB
mkg-48486	31	6	gene	gene	NOUN
mkg-48486	31	7	expression	expression	NOUN
mkg-48486	31	8	levels	level	NOUN
mkg-48486	31	9	to	to	PART
mkg-48486	31	10	decrease	decrease	VERB
mkg-48486	31	11	,	,	PUNCT
mkg-48486	31	12	and	and	CCONJ
mkg-48486	31	13	conversely	conversely	ADV
mkg-48486	31	14	,	,	PUNCT
mkg-48486	31	15	low	low	ADJ
mkg-48486	31	16	methylation	methylation	NOUN
mkg-48486	31	17	levels	level	NOUN
mkg-48486	31	18	will	will	AUX
mkg-48486	31	19	cause	cause	VERB
mkg-48486	31	20	gene	gene	NOUN
mkg-48486	31	21	expression	expression	NOUN
mkg-48486	31	22	levels	level	NOUN
mkg-48486	31	23	to	to	PART
mkg-48486	31	24	increase.10	increase.10	VERB
mkg-48486	31	25	cleft	cleft	NOUN
mkg-48486	31	26	lip	lip	NOUN
mkg-48486	31	27	is	be	AUX
mkg-48486	31	28	a	a	DET
mkg-48486	31	29	phenomenon	phenomenon	NOUN
mkg-48486	31	30	whereby	whereby	SCONJ
mkg-48486	31	31	the	the	DET
mkg-48486	31	32	lip	lip	NOUN
mkg-48486	31	33	area	area	NOUN
mkg-48486	31	34	fails	fail	VERB
mkg-48486	31	35	to	to	PART
mkg-48486	31	36	close	close	VERB
mkg-48486	31	37	during	during	ADP
mkg-48486	31	38	the	the	DET
mkg-48486	31	39	process	process	NOUN
mkg-48486	31	40	of	of	ADP
mkg-48486	31	41	facial	facial	ADJ
mkg-48486	31	42	formation	formation	NOUN
mkg-48486	31	43	when	when	SCONJ
mkg-48486	31	44	the	the	DET
mkg-48486	31	45	embryo	embryo	NOUN
mkg-48486	31	46	is	be	AUX
mkg-48486	31	47	between	between	ADP
mkg-48486	31	48	four	four	NUM
mkg-48486	31	49	and	and	CCONJ
mkg-48486	31	50	seven	seven	NUM
mkg-48486	31	51	weeks	week	NOUN
mkg-48486	31	52	of	of	ADP
mkg-48486	31	53	gestation	gestation	NOUN
mkg-48486	31	54	.	.	PUNCT
mkg-48486	32	1	cleft	cleft	NOUN
mkg-48486	32	2	palate	palate	NOUN
mkg-48486	32	3	is	be	AUX
mkg-48486	32	4	a	a	DET
mkg-48486	32	5	phenomenon	phenomenon	NOUN
mkg-48486	32	6	in	in	ADP
mkg-48486	32	7	which	which	PRON
mkg-48486	32	8	the	the	DET
mkg-48486	32	9	palate	palate	NOUN
mkg-48486	32	10	in	in	ADP
mkg-48486	32	11	the	the	DET
mkg-48486	32	12	mouth	mouth	NOUN
mkg-48486	32	13	fails	fail	VERB
mkg-48486	32	14	to	to	PART
mkg-48486	32	15	close	close	VERB
mkg-48486	32	16	during	during	ADP
mkg-48486	32	17	the	the	DET
mkg-48486	32	18	joining	join	VERB
mkg-48486	32	19	process	process	NOUN
mkg-48486	32	20	of	of	ADP
mkg-48486	32	21	the	the	DET
mkg-48486	32	22	upper	upper	ADJ
mkg-48486	32	23	and	and	CCONJ
mkg-48486	32	24	lower	low	ADJ
mkg-48486	32	25	parts	part	NOUN
mkg-48486	32	26	of	of	ADP
mkg-48486	32	27	the	the	DET
mkg-48486	32	28	mouth	mouth	NOUN
mkg-48486	32	29	,	,	PUNCT
mkg-48486	32	30	occurring	occur	VERB
mkg-48486	32	31	when	when	SCONJ
mkg-48486	32	32	the	the	DET
mkg-48486	32	33	embryo	embryo	NOUN
mkg-48486	32	34	is	be	AUX
mkg-48486	32	35	six	six	NUM
mkg-48486	32	36	to	to	PART
mkg-48486	32	37	nine	nine	NUM
mkg-48486	32	38	weeks	week	NOUN
mkg-48486	32	39	of	of	ADP
mkg-48486	32	40	gestation	gestation	NOUN
mkg-48486	32	41	.	.	PUNCT
mkg-48486	33	1	cl	cl	NOUN
mkg-48486	33	2	/	/	SYM
mkg-48486	33	3	p	p	NOUN
mkg-48486	33	4	is	be	AUX
mkg-48486	33	5	caused	cause	VERB
mkg-48486	33	6	by	by	ADP
mkg-48486	33	7	multiple	multiple	ADJ
mkg-48486	33	8	factors	factor	NOUN
mkg-48486	33	9	,	,	PUNCT
mkg-48486	33	10	including	include	VERB
mkg-48486	33	11	genetic	genetic	ADJ
mkg-48486	33	12	factors	factor	NOUN
mkg-48486	33	13	,	,	PUNCT
mkg-48486	33	14	the	the	DET
mkg-48486	33	15	environment	environment	NOUN
mkg-48486	33	16	during	during	ADP
mkg-48486	33	17	pregnancy	pregnancy	NOUN
mkg-48486	33	18	,	,	PUNCT
mkg-48486	33	19	carcinogens	carcinogen	NOUN
mkg-48486	33	20	,	,	PUNCT
mkg-48486	33	21	and	and	CCONJ
mkg-48486	33	22	exposure	exposure	NOUN
mkg-48486	33	23	to	to	ADP
mkg-48486	33	24	chemicals.11	chemicals.11	VERB
mkg-48486	33	25	there	there	PRON
mkg-48486	33	26	are	be	VERB
mkg-48486	33	27	several	several	ADJ
mkg-48486	33	28	methods	method	NOUN
mkg-48486	33	29	for	for	ADP
mkg-48486	33	30	detecting	detect	VERB
mkg-48486	33	31	methylation	methylation	NOUN
mkg-48486	33	32	in	in	ADP
mkg-48486	33	33	a	a	DET
mkg-48486	33	34	gene	gene	NOUN
mkg-48486	33	35	.	.	PUNCT
mkg-48486	34	1	it	it	PRON
mkg-48486	34	2	is	be	AUX
mkg-48486	34	3	often	often	ADV
mkg-48486	34	4	done	do	VERB
mkg-48486	34	5	with	with	ADP
mkg-48486	34	6	a	a	DET
mkg-48486	34	7	polymerase	polymerase	NOUN
mkg-48486	34	8	chain	chain	NOUN
mkg-48486	34	9	reaction	reaction	NOUN
mkg-48486	34	10	(	(	PUNCT
mkg-48486	34	11	pcr	pcr	NOUN
mkg-48486	34	12	)	)	PUNCT
mkg-48486	34	13	method	method	NOUN
mkg-48486	34	14	using	use	VERB
mkg-48486	34	15	primers	primer	NOUN
mkg-48486	34	16	that	that	PRON
mkg-48486	34	17	are	be	AUX
mkg-48486	34	18	designed	design	VERB
mkg-48486	34	19	to	to	PART
mkg-48486	34	20	recognize	recognize	VERB
mkg-48486	34	21	methylated	methylate	VERB
mkg-48486	34	22	and	and	CCONJ
mkg-48486	34	23	unmethylated	unmethylated	ADJ
mkg-48486	34	24	areas	area	NOUN
mkg-48486	34	25	.	.	PUNCT
mkg-48486	35	1	the	the	DET
mkg-48486	35	2	weakness	weakness	NOUN
mkg-48486	35	3	of	of	ADP
mkg-48486	35	4	this	this	DET
mkg-48486	35	5	method	method	NOUN
mkg-48486	35	6	is	be	AUX
mkg-48486	35	7	that	that	SCONJ
mkg-48486	35	8	we	we	PRON
mkg-48486	35	9	can	can	AUX
mkg-48486	35	10	only	only	ADV
mkg-48486	35	11	observe	observe	VERB
mkg-48486	35	12	it	it	PRON
mkg-48486	35	13	qualitatively	qualitatively	ADV
mkg-48486	35	14	by	by	ADP
mkg-48486	35	15	looking	look	VERB
mkg-48486	35	16	at	at	ADP
mkg-48486	35	17	the	the	DET
mkg-48486	35	18	presence	presence	NOUN
mkg-48486	35	19	or	or	CCONJ
mkg-48486	35	20	absence	absence	NOUN
mkg-48486	35	21	of	of	ADP
mkg-48486	35	22	dna	dna	PROPN
mkg-48486	35	23	bands	band	NOUN
mkg-48486	35	24	in	in	ADP
mkg-48486	35	25	electrophoresis.12	electrophoresis.12	NOUN
mkg-48486	35	26	low	low	ADJ
mkg-48486	35	27	levels	level	NOUN
mkg-48486	35	28	of	of	ADP
mkg-48486	35	29	methylation	methylation	NOUN
mkg-48486	35	30	can	can	AUX
mkg-48486	35	31	not	not	PART
mkg-48486	35	32	be	be	AUX
mkg-48486	35	33	detected	detect	VERB
mkg-48486	35	34	with	with	ADP
mkg-48486	35	35	this	this	DET
mkg-48486	35	36	method	method	NOUN
mkg-48486	35	37	.	.	PUNCT
mkg-48486	36	1	the	the	DET
mkg-48486	36	2	latest	late	ADJ
mkg-48486	36	3	technology	technology	NOUN
mkg-48486	36	4	today	today	NOUN
mkg-48486	36	5	,	,	PUNCT
mkg-48486	36	6	namely	namely	ADV
mkg-48486	36	7	pyrosequencing	pyrosequencing	NOUN
mkg-48486	36	8	,	,	PUNCT
mkg-48486	36	9	can	can	AUX
mkg-48486	36	10	determine	determine	VERB
mkg-48486	36	11	the	the	DET
mkg-48486	36	12	percentage	percentage	NOUN
mkg-48486	36	13	methylation	methylation	NOUN
mkg-48486	36	14	of	of	ADP
mkg-48486	36	15	a	a	DET
mkg-48486	36	16	gene	gene	NOUN
mkg-48486	36	17	(	(	PUNCT
mkg-48486	36	18	quantitative	quantitative	ADJ
mkg-48486	36	19	data	datum	NOUN
mkg-48486	36	20	)	)	PUNCT
mkg-48486	36	21	in	in	ADP
mkg-48486	36	22	a	a	DET
mkg-48486	36	23	way	way	NOUN
mkg-48486	36	24	that	that	PRON
mkg-48486	36	25	is	be	AUX
mkg-48486	36	26	simpler	simple	ADJ
mkg-48486	36	27	,	,	PUNCT
mkg-48486	36	28	more	more	ADV
mkg-48486	36	29	accurate	accurate	ADJ
mkg-48486	36	30	and	and	CCONJ
mkg-48486	36	31	faster	fast	ADJ
mkg-48486	36	32	than	than	ADP
mkg-48486	36	33	the	the	DET
mkg-48486	36	34	pcr	pcr	ADJ
mkg-48486	36	35	method	method	NOUN
mkg-48486	36	36	,	,	PUNCT
mkg-48486	36	37	so	so	SCONJ
mkg-48486	36	38	it	it	PRON
mkg-48486	36	39	is	be	AUX
mkg-48486	36	40	now	now	ADV
mkg-48486	36	41	possible	possible	ADJ
mkg-48486	36	42	to	to	PART
mkg-48486	36	43	detect	detect	VERB
mkg-48486	36	44	a	a	DET
mkg-48486	36	45	low	low	ADJ
mkg-48486	36	46	percentage	percentage	NOUN
mkg-48486	36	47	of	of	ADP
mkg-48486	36	48	methylation.12	methylation.12	NOUN
mkg-48486	36	49	this	this	DET
mkg-48486	36	50	study	study	NOUN
mkg-48486	36	51	aims	aim	VERB
mkg-48486	36	52	to	to	PART
mkg-48486	36	53	optimize	optimize	VERB
mkg-48486	36	54	detection	detection	NOUN
mkg-48486	36	55	of	of	ADP
mkg-48486	36	56	mthfr	mthfr	PROPN
mkg-48486	36	57	gene	gene	NOUN
mkg-48486	36	58	methylation	methylation	NOUN
mkg-48486	36	59	using	use	VERB
mkg-48486	36	60	the	the	DET
mkg-48486	36	61	pyrosequencing	pyrosequencing	NOUN
mkg-48486	36	62	method	method	NOUN
mkg-48486	36	63	.	.	PUNCT
mkg-48486	37	1	materials	material	NOUN
mkg-48486	37	2	and	and	CCONJ
mkg-48486	37	3	methods	method	NOUN
mkg-48486	37	4	the	the	DET
mkg-48486	37	5	research	research	NOUN
mkg-48486	37	6	subjects	subject	NOUN
mkg-48486	37	7	were	be	AUX
mkg-48486	37	8	cl	cl	NOUN
mkg-48486	37	9	/	/	SYM
mkg-48486	37	10	p	p	NOUN
mkg-48486	37	11	sufferers	sufferer	NOUN
mkg-48486	37	12	and	and	CCONJ
mkg-48486	37	13	their	their	PRON
mkg-48486	37	14	families	family	NOUN
mkg-48486	37	15	who	who	PRON
mkg-48486	37	16	were	be	AUX
mkg-48486	37	17	registered	register	VERB
mkg-48486	37	18	with	with	ADP
mkg-48486	37	19	the	the	DET
mkg-48486	37	20	foster	foster	ADJ
mkg-48486	37	21	foundation	foundation	NOUN
mkg-48486	37	22	for	for	ADP
mkg-48486	37	23	cleft	cleft	ADJ
mkg-48486	37	24	lip	lip	NOUN
mkg-48486	37	25	and	and	CCONJ
mkg-48486	37	26	palate	palate	VERB
mkg-48486	37	27	patients	patient	NOUN
mkg-48486	37	28	.	.	PUNCT
mkg-48486	38	1	the	the	DET
mkg-48486	38	2	study	study	NOUN
mkg-48486	38	3	protocol	protocol	NOUN
mkg-48486	38	4	was	be	AUX
mkg-48486	38	5	approved	approve	VERB
mkg-48486	38	6	by	by	ADP
mkg-48486	38	7	the	the	DET
mkg-48486	38	8	research	research	NOUN
mkg-48486	38	9	ethics	ethic	NOUN
mkg-48486	38	10	committee	committee	PROPN
mkg-48486	38	11	,	,	PUNCT
mkg-48486	38	12	universitas	universita	NOUN
mkg-48486	38	13	padjadjaran	padjadjaran	NOUN
mkg-48486	38	14	,	,	PUNCT
mkg-48486	38	15	bandung	bandung	PROPN
mkg-48486	38	16	(	(	PUNCT
mkg-48486	38	17	no	no	INTJ
mkg-48486	38	18	.	.	NOUN
mkg-48486	38	19	773	773	NUM
mkg-48486	38	20	/	/	SYM
mkg-48486	38	21	un6.kep	un6.kep	NOUN
mkg-48486	38	22	/	/	SYM
mkg-48486	38	23	ec/2019	ec/2019	NOUN
mkg-48486	38	24	)	)	PUNCT
mkg-48486	38	25	.	.	PUNCT
mkg-48486	39	1	this	this	DET
mkg-48486	39	2	study	study	NOUN
mkg-48486	39	3	used	use	VERB
mkg-48486	39	4	blood	blood	NOUN
mkg-48486	39	5	samples	sample	NOUN
mkg-48486	39	6	from	from	ADP
mkg-48486	39	7	20	20	NUM
mkg-48486	39	8	patients	patient	NOUN
mkg-48486	39	9	with	with	ADP
mkg-48486	39	10	cl	cl	NOUN
mkg-48486	39	11	/	/	SYM
mkg-48486	39	12	p	p	NOUN
mkg-48486	39	13	and	and	CCONJ
mkg-48486	39	14	44	44	NUM
mkg-48486	39	15	normal	normal	ADJ
mkg-48486	39	16	patients	patient	NOUN
mkg-48486	39	17	and	and	CCONJ
mkg-48486	39	18	was	be	AUX
mkg-48486	39	19	conducted	conduct	VERB
mkg-48486	39	20	at	at	ADP
mkg-48486	39	21	the	the	DET
mkg-48486	39	22	molecular	molecular	ADJ
mkg-48486	39	23	genetics	genetic	NOUN
mkg-48486	39	24	laboratory	laboratory	NOUN
mkg-48486	39	25	,	,	PUNCT
mkg-48486	39	26	faculty	faculty	NOUN
mkg-48486	39	27	of	of	ADP
mkg-48486	39	28	medicine	medicine	NOUN
mkg-48486	39	29	,	,	PUNCT
mkg-48486	39	30	universitas	universita	NOUN
mkg-48486	39	31	padjadjaran	padjadjaran	NOUN
mkg-48486	39	32	in	in	ADP
mkg-48486	39	33	2022	2022	NUM
mkg-48486	39	34	.	.	PUNCT
mkg-48486	40	1	this	this	DET
mkg-48486	40	2	research	research	NOUN
mkg-48486	40	3	is	be	AUX
mkg-48486	40	4	exploratory	exploratory	ADJ
mkg-48486	40	5	,	,	PUNCT
mkg-48486	40	6	and	and	CCONJ
mkg-48486	40	7	several	several	ADJ
mkg-48486	40	8	stages	stage	NOUN
mkg-48486	40	9	of	of	ADP
mkg-48486	40	10	examination	examination	NOUN
mkg-48486	40	11	are	be	AUX
mkg-48486	40	12	needed	need	VERB
mkg-48486	40	13	to	to	PART
mkg-48486	40	14	detect	detect	VERB
mkg-48486	40	15	the	the	DET
mkg-48486	40	16	level	level	NOUN
mkg-48486	40	17	of	of	ADP
mkg-48486	40	18	methylation	methylation	NOUN
mkg-48486	40	19	in	in	ADP
mkg-48486	40	20	the	the	DET
mkg-48486	40	21	mthfr	mthfr	NOUN
mkg-48486	40	22	gene	gene	NOUN
mkg-48486	40	23	.	.	PUNCT
mkg-48486	41	1	as	as	ADV
mkg-48486	41	2	much	much	ADJ
mkg-48486	41	3	as	as	ADP
mkg-48486	41	4	3	3	NUM
mkg-48486	41	5	ml	ml	NOUN
mkg-48486	41	6	of	of	ADP
mkg-48486	41	7	venous	venous	ADJ
mkg-48486	41	8	blood	blood	NOUN
mkg-48486	41	9	was	be	AUX
mkg-48486	41	10	collected	collect	VERB
mkg-48486	41	11	in	in	ADP
mkg-48486	41	12	edta	edta	NOUN
mkg-48486	41	13	tubes	tube	NOUN
mkg-48486	41	14	.	.	PUNCT
mkg-48486	42	1	dna	dna	PROPN
mkg-48486	42	2	was	be	AUX
mkg-48486	42	3	isolated	isolate	VERB
mkg-48486	42	4	from	from	ADP
mkg-48486	42	5	the	the	DET
mkg-48486	42	6	blood	blood	NOUN
mkg-48486	42	7	of	of	ADP
mkg-48486	42	8	cl	cl	NOUN
mkg-48486	42	9	/	/	SYM
mkg-48486	42	10	p	p	NOUN
mkg-48486	42	11	patients	patient	NOUN
mkg-48486	42	12	and	and	CCONJ
mkg-48486	42	13	normal	normal	ADJ
mkg-48486	42	14	controls	control	NOUN
mkg-48486	42	15	using	use	VERB
mkg-48486	42	16	the	the	DET
mkg-48486	42	17	quick	quick	ADJ
mkg-48486	42	18	-	-	PUNCT
mkg-48486	42	19	dna	dna	NOUN
mkg-48486	42	20	™	™	PROPN
mkg-48486	42	21	miniprep	miniprep	NOUN
mkg-48486	42	22	plus	plus	CCONJ
mkg-48486	42	23	kit	kit	NOUN
mkg-48486	42	24	from	from	ADP
mkg-48486	42	25	zymo	zymo	NOUN
mkg-48486	42	26	research	research	NOUN
mkg-48486	42	27	(	(	PUNCT
mkg-48486	42	28	catalog	catalog	NOUN
mkg-48486	42	29	no	no	NOUN
mkg-48486	42	30	.	.	PUNCT
mkg-48486	43	1	d4069	d4069	NOUN
mkg-48486	43	2	)	)	PUNCT
mkg-48486	43	3	.	.	PUNCT
mkg-48486	44	1	dna	dna	PROPN
mkg-48486	44	2	was	be	AUX
mkg-48486	44	3	dissolved	dissolve	VERB
mkg-48486	44	4	in	in	ADP
mkg-48486	44	5	100	100	NUM
mkg-48486	44	6	µl	µl	ADP
mkg-48486	44	7	of	of	ADP
mkg-48486	44	8	buffer	buffer	NOUN
mkg-48486	44	9	fluid	fluid	NOUN
mkg-48486	44	10	,	,	PUNCT
mkg-48486	44	11	and	and	CCONJ
mkg-48486	44	12	the	the	DET
mkg-48486	44	13	bisulfite	bisulfite	NOUN
mkg-48486	44	14	conversion	conversion	NOUN
mkg-48486	44	15	step	step	NOUN
mkg-48486	44	16	followed	follow	VERB
mkg-48486	44	17	.	.	PUNCT
mkg-48486	45	1	dna	dna	PROPN
mkg-48486	45	2	bisulfite	bisulfite	NOUN
mkg-48486	45	3	conversion	conversion	NOUN
mkg-48486	45	4	is	be	AUX
mkg-48486	45	5	a	a	DET
mkg-48486	45	6	technique	technique	NOUN
mkg-48486	45	7	used	use	VERB
mkg-48486	45	8	to	to	PART
mkg-48486	45	9	differentiate	differentiate	VERB
mkg-48486	45	10	between	between	ADP
mkg-48486	45	11	methylated	methylate	VERB
mkg-48486	45	12	and	and	CCONJ
mkg-48486	45	13	unmethylated	unmethylated	ADJ
mkg-48486	45	14	cytosine	cytosine	NOUN
mkg-48486	45	15	bases	basis	NOUN
mkg-48486	45	16	in	in	ADP
mkg-48486	45	17	dna	dna	PROPN
mkg-48486	45	18	methylation	methylation	NOUN
mkg-48486	45	19	studies	study	NOUN
mkg-48486	45	20	.	.	PUNCT
mkg-48486	46	1	the	the	DET
mkg-48486	46	2	bisulfite	bisulfite	NOUN
mkg-48486	46	3	modification	modification	NOUN
mkg-48486	46	4	technique	technique	NOUN
mkg-48486	46	5	uses	use	VERB
mkg-48486	46	6	sodium	sodium	NOUN
mkg-48486	46	7	bisulfite	bisulfite	NOUN
mkg-48486	46	8	,	,	PUNCT
mkg-48486	46	9	which	which	PRON
mkg-48486	46	10	changes	change	VERB
mkg-48486	46	11	the	the	DET
mkg-48486	46	12	unmethylated	unmethylated	ADJ
mkg-48486	46	13	base	base	NOUN
mkg-48486	46	14	of	of	ADP
mkg-48486	46	15	cytosine	cytosine	NOUN
mkg-48486	46	16	to	to	ADP
mkg-48486	46	17	uracil	uracil	NUM
mkg-48486	46	18	,	,	PUNCT
mkg-48486	46	19	while	while	SCONJ
mkg-48486	46	20	5	5	NUM
mkg-48486	46	21	-	-	PUNCT
mkg-48486	46	22	methylcytosine	methylcytosine	NOUN
mkg-48486	46	23	will	will	AUX
mkg-48486	46	24	not	not	PART
mkg-48486	46	25	change	change	VERB
mkg-48486	46	26	.	.	PUNCT
mkg-48486	47	1	extracted	extract	VERB
mkg-48486	47	2	dna	dna	PROPN
mkg-48486	47	3	was	be	AUX
mkg-48486	47	4	first	first	ADV
mkg-48486	47	5	treated	treat	VERB
mkg-48486	47	6	with	with	ADP
mkg-48486	47	7	bisulfite	bisulfite	NOUN
mkg-48486	47	8	using	use	VERB
mkg-48486	47	9	the	the	DET
mkg-48486	47	10	reagent	reagent	ADJ
mkg-48486	47	11	ez	ez	PROPN
mkg-48486	47	12	dna	dna	PROPN
mkg-48486	47	13	methylation	methylation	NOUN
mkg-48486	47	14	kit	kit	NOUN
mkg-48486	47	15	from	from	ADP
mkg-48486	47	16	zymo	zymo	NOUN
mkg-48486	47	17	research	research	NOUN
mkg-48486	47	18	(	(	PUNCT
mkg-48486	47	19	catalog	catalog	NOUN
mkg-48486	47	20	no	no	NOUN
mkg-48486	47	21	.	.	PUNCT
mkg-48486	48	1	d5001	d5001	NOUN
mkg-48486	48	2	)	)	PUNCT
mkg-48486	48	3	.	.	PUNCT
mkg-48486	49	1	assays	assay	NOUN
mkg-48486	49	2	for	for	ADP
mkg-48486	49	3	examining	examine	VERB
mkg-48486	49	4	methylation	methylation	NOUN
mkg-48486	49	5	using	use	VERB
mkg-48486	49	6	the	the	DET
mkg-48486	49	7	pyrosequencing	pyrosequencing	NOUN
mkg-48486	49	8	method	method	NOUN
mkg-48486	49	9	were	be	AUX
mkg-48486	49	10	carried	carry	VERB
mkg-48486	49	11	out	out	ADP
mkg-48486	49	12	in	in	ADP
mkg-48486	49	13	silico	silico	NOUN
mkg-48486	49	14	using	use	VERB
mkg-48486	49	15	the	the	DET
mkg-48486	49	16	help	help	NOUN
mkg-48486	49	17	of	of	ADP
mkg-48486	49	18	several	several	ADJ
mkg-48486	49	19	genome	genome	NOUN
mkg-48486	49	20	browsers	browser	NOUN
mkg-48486	49	21	(	(	PUNCT
mkg-48486	49	22	ensembl	ensembl	PROPN
mkg-48486	49	23	and	and	CCONJ
mkg-48486	49	24	ucsc	ucsc	PROPN
mkg-48486	49	25	)	)	PUNCT
mkg-48486	49	26	as	as	ADV
mkg-48486	49	27	well	well	ADV
mkg-48486	49	28	as	as	ADP
mkg-48486	49	29	pyromark	pyromark	NOUN
mkg-48486	49	30	assay	assay	NOUN
mkg-48486	49	31	design	design	NOUN
mkg-48486	49	32	software	software	NOUN
mkg-48486	49	33	by	by	ADP
mkg-48486	49	34	qiagen	qiagen	PROPN
mkg-48486	49	35	.	.	PUNCT
mkg-48486	50	1	the	the	DET
mkg-48486	50	2	location	location	NOUN
mkg-48486	50	3	of	of	ADP
mkg-48486	50	4	the	the	DET
mkg-48486	50	5	mthfr	mthfr	NOUN
mkg-48486	50	6	gene	gene	NOUN
mkg-48486	50	7	is	be	AUX
mkg-48486	50	8	known	know	VERB
mkg-48486	50	9	due	due	ADP
mkg-48486	50	10	to	to	ADP
mkg-48486	50	11	the	the	DET
mkg-48486	50	12	help	help	NOUN
mkg-48486	50	13	of	of	ADP
mkg-48486	50	14	the	the	DET
mkg-48486	50	15	browser	browser	NOUN
mkg-48486	50	16	genome	genome	NOUN
mkg-48486	50	17	ensembl	ensembl	NOUN
mkg-48486	50	18	;	;	PUNCT
mkg-48486	50	19	it	it	PRON
mkg-48486	50	20	is	be	AUX
mkg-48486	50	21	on	on	ADP
mkg-48486	50	22	the	the	DET
mkg-48486	50	23	chromosome	chromosome	NOUN
mkg-48486	50	24	1	1	NUM
mkg-48486	50	25	reverse	reverse	NOUN
mkg-48486	50	26	strand	strand	NOUN
mkg-48486	50	27	with	with	ADP
mkg-48486	50	28	coordinates	coordinate	NOUN
mkg-48486	50	29	11,785,723–11,806,455	11,785,723–11,806,455	NUM
mkg-48486	50	30	(	(	PUNCT
mkg-48486	50	31	figure	figure	NOUN
mkg-48486	50	32	1	1	NUM
mkg-48486	50	33	)	)	PUNCT
mkg-48486	50	34	.	.	PUNCT
mkg-48486	51	1	the	the	DET
mkg-48486	51	2	nucleotide	nucleotide	ADJ
mkg-48486	51	3	target	target	NOUN
mkg-48486	51	4	for	for	ADP
mkg-48486	51	5	methylation	methylation	NOUN
mkg-48486	51	6	is	be	AUX
mkg-48486	51	7	located	locate	VERB
mkg-48486	51	8	on	on	ADP
mkg-48486	51	9	the	the	DET
mkg-48486	51	10	cpg	cpg	NOUN
mkg-48486	51	11	island	island	NOUN
mkg-48486	51	12	on	on	ADP
mkg-48486	51	13	the	the	DET
mkg-48486	51	14	promoter	promoter	NOUN
mkg-48486	51	15	of	of	ADP
mkg-48486	51	16	the	the	DET
mkg-48486	51	17	mthfr	mthfr	PROPN
mkg-48486	51	18	gene	gene	NOUN
mkg-48486	51	19	.	.	PUNCT
mkg-48486	52	1	the	the	DET
mkg-48486	52	2	ucsc	ucsc	PROPN
mkg-48486	52	3	genome	genome	NOUN
mkg-48486	52	4	browser	browser	NOUN
mkg-48486	52	5	can	can	AUX
mkg-48486	52	6	make	make	VERB
mkg-48486	52	7	it	it	PRON
mkg-48486	52	8	easier	easy	ADJ
mkg-48486	52	9	to	to	PART
mkg-48486	52	10	detect	detect	VERB
mkg-48486	52	11	the	the	DET
mkg-48486	52	12	location	location	NOUN
mkg-48486	52	13	of	of	ADP
mkg-48486	52	14	the	the	DET
mkg-48486	52	15	cpg	cpg	NOUN
mkg-48486	52	16	island	island	NOUN
mkg-48486	52	17	,	,	PUNCT
mkg-48486	52	18	which	which	PRON
mkg-48486	52	19	is	be	AUX
mkg-48486	52	20	at	at	ADP
mkg-48486	52	21	position	position	NOUN
mkg-48486	52	22	chr1:11,805,406	chr1:11,805,406	PROPN
mkg-48486	52	23	–	–	PUNCT
mkg-48486	52	24	11,806,509	11,806,509	NUM
mkg-48486	52	25	.	.	PUNCT
mkg-48486	53	1	the	the	DET
mkg-48486	53	2	cpg	cpg	PROPN
mkg-48486	53	3	island	island	NOUN
mkg-48486	53	4	sequence	sequence	NOUN
mkg-48486	53	5	of	of	ADP
mkg-48486	53	6	the	the	DET
mkg-48486	53	7	mthfr	mthfr	PROPN
mkg-48486	53	8	gene	gene	NOUN
mkg-48486	53	9	was	be	AUX
mkg-48486	53	10	entered	enter	VERB
mkg-48486	53	11	into	into	ADP
mkg-48486	53	12	the	the	DET
mkg-48486	53	13	pyromark	pyromark	NOUN
mkg-48486	53	14	assay	assay	PROPN
mkg-48486	53	15	design	design	NOUN
mkg-48486	53	16	software	software	NOUN
mkg-48486	53	17	and	and	CCONJ
mkg-48486	53	18	the	the	DET
mkg-48486	53	19	area	area	NOUN
mkg-48486	53	20	where	where	SCONJ
mkg-48486	53	21	the	the	DET
mkg-48486	53	22	methylation	methylation	NOUN
mkg-48486	53	23	level	level	NOUN
mkg-48486	53	24	will	will	AUX
mkg-48486	53	25	be	be	AUX
mkg-48486	53	26	examined	examine	VERB
mkg-48486	53	27	was	be	AUX
mkg-48486	53	28	figure	figure	NOUN
mkg-48486	53	29	1	1	NUM
mkg-48486	53	30	.	.	PUNCT
mkg-48486	54	1	search	search	NOUN
mkg-48486	54	2	results	result	NOUN
mkg-48486	54	3	for	for	ADP
mkg-48486	54	4	the	the	DET
mkg-48486	54	5	location	location	NOUN
mkg-48486	54	6	of	of	ADP
mkg-48486	54	7	the	the	DET
mkg-48486	54	8	gene	gene	NOUN
mkg-48486	54	9	with	with	ADP
mkg-48486	54	10	ensembl	ensembl	PROPN
mkg-48486	54	11	genome	genome	NOUN
mkg-48486	54	12	browser	browser	NOUN
mkg-48486	54	13	.	.	PUNCT
mkg-48486	55	1	copyright	copyright	NOUN
mkg-48486	55	2	©	©	ADP
mkg-48486	55	3	2024	2024	NUM
mkg-48486	55	4	dental	dental	ADJ
mkg-48486	55	5	journal	journal	NOUN
mkg-48486	55	6	(	(	PUNCT
mkg-48486	55	7	majalah	majalah	PROPN
mkg-48486	55	8	kedokteran	kedokteran	PROPN
mkg-48486	55	9	gigi	gigi	PROPN
mkg-48486	55	10	)	)	PUNCT
mkg-48486	56	1	p	p	X
mkg-48486	56	2	-	-	PUNCT
mkg-48486	56	3	issn	issn	NOUN
mkg-48486	56	4	:	:	PUNCT
mkg-48486	56	5	1978	1978	NUM
mkg-48486	56	6	-	-	SYM
mkg-48486	56	7	3728	3728	NUM
mkg-48486	56	8	;	;	PUNCT
mkg-48486	56	9	e	e	X
mkg-48486	56	10	-	-	PUNCT
mkg-48486	56	11	issn	issn	ADJ
mkg-48486	56	12	:	:	PUNCT
mkg-48486	56	13	2442	2442	NUM
mkg-48486	56	14	-	-	SYM
mkg-48486	56	15	9740	9740	NUM
mkg-48486	56	16	.	.	PUNCT
mkg-48486	57	1	accredited	accredit	VERB
mkg-48486	57	2	no	no	INTJ
mkg-48486	57	3	.	.	PROPN
mkg-48486	58	1	158	158	NUM
mkg-48486	58	2	/	/	SYM
mkg-48486	58	3	e	e	NOUN
mkg-48486	58	4	/	/	SYM
mkg-48486	58	5	kpt/2021	kpt/2021	NOUN
mkg-48486	58	6	.	.	PUNCT
mkg-48486	59	1	open	open	ADJ
mkg-48486	59	2	access	access	NOUN
mkg-48486	59	3	under	under	ADP
mkg-48486	59	4	cc	cc	NOUN
mkg-48486	59	5	-	-	PUNCT
mkg-48486	59	6	by	by	ADP
mkg-48486	59	7	-	-	PUNCT
mkg-48486	59	8	sa	sa	NOUN
mkg-48486	59	9	license	license	NOUN
mkg-48486	59	10	.	.	PUNCT
mkg-48486	60	1	available	available	ADJ
mkg-48486	60	2	at	at	ADP
mkg-48486	60	3	https://e-journal.unair.ac.id/mkg/index	https://e-journal.unair.ac.id/mkg/index	NOUN
mkg-48486	60	4	doi	doi	NOUN
mkg-48486	60	5	:	:	PUNCT
mkg-48486	60	6	10.20473	10.20473	NUM
mkg-48486	60	7	/	/	SYM
mkg-48486	60	8	j.djmkg.v57.i3.p184–188	j.djmkg.v57.i3.p184–188	NOUN
mkg-48486	60	9	https://e-journal.unair.ac.id/mkg/index	https://e-journal.unair.ac.id/mkg/index	NOUN
mkg-48486	60	10	https://doi.org/10.20473/j.djmkg.v57.i3.p184-188	https://doi.org/10.20473/j.djmkg.v57.i3.p184-188	VERB
mkg-48486	60	11	186maskoen	186maskoen	PROPN
mkg-48486	60	12	et	et	PROPN
mkg-48486	60	13	al	al	PROPN
mkg-48486	60	14	.	.	PROPN
mkg-48486	60	15	dent	dent	PROPN
mkg-48486	60	16	.	.	PUNCT
mkg-48486	61	1	j.	j.	PROPN
mkg-48486	61	2	(	(	PUNCT
mkg-48486	61	3	majalah	majalah	PROPN
mkg-48486	61	4	kedokteran	kedokteran	PROPN
mkg-48486	61	5	gigi	gigi	PROPN
mkg-48486	61	6	)	)	PUNCT
mkg-48486	61	7	2024	2024	NUM
mkg-48486	61	8	september	september	PROPN
mkg-48486	61	9	;	;	PUNCT
mkg-48486	61	10	57(3	57(3	NUM
mkg-48486	61	11	):	):	PUNCT
mkg-48486	61	12	184–188	184–188	NUM
mkg-48486	61	13	determined	determine	VERB
mkg-48486	61	14	.	.	PUNCT
mkg-48486	62	1	in	in	ADP
mkg-48486	62	2	this	this	DET
mkg-48486	62	3	study	study	NOUN
mkg-48486	62	4	,	,	PUNCT
mkg-48486	62	5	we	we	PRON
mkg-48486	62	6	aimed	aim	VERB
mkg-48486	62	7	to	to	PART
mkg-48486	62	8	detect	detect	VERB
mkg-48486	62	9	the	the	DET
mkg-48486	62	10	percentage	percentage	NOUN
mkg-48486	62	11	of	of	ADP
mkg-48486	62	12	methylation	methylation	NOUN
mkg-48486	62	13	at	at	ADP
mkg-48486	62	14	three	three	NUM
mkg-48486	62	15	methylation	methylation	NOUN
mkg-48486	62	16	points	point	NOUN
mkg-48486	62	17	located	locate	VERB
mkg-48486	62	18	at	at	ADP
mkg-48486	62	19	11,805,507–11,805,529	11,805,507–11,805,529	NUM
mkg-48486	62	20	.	.	PUNCT
mkg-48486	62	21	considerations	consideration	NOUN
mkg-48486	62	22	for	for	ADP
mkg-48486	62	23	choosing	choose	VERB
mkg-48486	62	24	a	a	DET
mkg-48486	62	25	methylation	methylation	NOUN
mkg-48486	62	26	target	target	NOUN
mkg-48486	62	27	were	be	AUX
mkg-48486	62	28	that	that	SCONJ
mkg-48486	62	29	it	it	PRON
mkg-48486	62	30	is	be	AUX
mkg-48486	62	31	easily	easily	ADV
mkg-48486	62	32	amplified	amplify	VERB
mkg-48486	62	33	by	by	ADP
mkg-48486	62	34	forward	forward	ADV
mkg-48486	62	35	and	and	CCONJ
mkg-48486	62	36	reverse	reverse	VERB
mkg-48486	62	37	primers	primer	NOUN
mkg-48486	62	38	and	and	CCONJ
mkg-48486	62	39	that	that	SCONJ
mkg-48486	62	40	the	the	DET
mkg-48486	62	41	maximum	maximum	ADJ
mkg-48486	62	42	length	length	NOUN
mkg-48486	62	43	of	of	ADP
mkg-48486	62	44	the	the	DET
mkg-48486	62	45	pcr	pcr	ADJ
mkg-48486	62	46	product	product	NOUN
mkg-48486	62	47	is	be	AUX
mkg-48486	62	48	not	not	PART
mkg-48486	62	49	more	more	ADJ
mkg-48486	62	50	than	than	ADP
mkg-48486	62	51	200	200	NUM
mkg-48486	62	52	bp	bp	NOUN
mkg-48486	62	53	.	.	PUNCT
mkg-48486	63	1	from	from	ADP
mkg-48486	63	2	this	this	DET
mkg-48486	63	3	software	software	NOUN
mkg-48486	63	4	,	,	PUNCT
mkg-48486	63	5	we	we	PRON
mkg-48486	63	6	obtained	obtain	VERB
mkg-48486	63	7	the	the	DET
mkg-48486	63	8	information	information	NOUN
mkg-48486	63	9	needed	need	VERB
mkg-48486	63	10	to	to	PART
mkg-48486	63	11	carry	carry	VERB
mkg-48486	63	12	out	out	ADP
mkg-48486	63	13	methylation	methylation	NOUN
mkg-48486	63	14	tests	test	NOUN
mkg-48486	63	15	using	use	VERB
mkg-48486	63	16	the	the	DET
mkg-48486	63	17	pyrosequencing	pyrosequencing	NOUN
mkg-48486	63	18	method	method	NOUN
mkg-48486	63	19	.	.	PUNCT
mkg-48486	64	1	the	the	DET
mkg-48486	64	2	primary	primary	ADJ
mkg-48486	64	3	sequence	sequence	NOUN
mkg-48486	64	4	obtained	obtain	VERB
mkg-48486	64	5	was	be	AUX
mkg-48486	64	6	as	as	SCONJ
mkg-48486	64	7	follows	follow	VERB
mkg-48486	64	8	:	:	PUNCT
mkg-48486	64	9	forward	forward	ADJ
mkg-48486	64	10	primer	primer	NOUN
mkg-48486	64	11	5’-agg	5’-agg	NUM
mkg-48486	64	12	agg	agg	PROPN
mkg-48486	64	13	ggt	ggt	NOUN
mkg-48486	64	14	tat	tat	PROPN
mkg-48486	64	15	gag	gag	NOUN
mkg-48486	64	16	aaa	aaa	NOUN
mkg-48486	64	17	ag-3	ag-3	PUNCT
mkg-48486	64	18	’	'	PUNCT
mkg-48486	64	19	,	,	PUNCT
mkg-48486	64	20	reverse	reverse	ADJ
mkg-48486	64	21	primer	primer	NOUN
mkg-48486	64	22	5’-biotinacc	5’-biotinacc	PROPN
mkg-48486	64	23	taa	taa	X
mkg-48486	64	24	aaa	aaa	NOUN
mkg-48486	64	25	ccc	ccc	PROPN
mkg-48486	64	26	caa	caa	PROPN
mkg-48486	64	27	cca	cca	PROPN
mkg-48486	64	28	aaa	aaa	PROPN
mkg-48486	64	29	ctc	ctc	PROPN
mkg-48486	64	30	t-3	t-3	NOUN
mkg-48486	64	31	’	'	PUNCT
mkg-48486	64	32	,	,	PUNCT
mkg-48486	64	33	sequencing	sequence	VERB
mkg-48486	64	34	primer	primer	NOUN
mkg-48486	64	35	5’-ggt	5’-ggt	NUM
mkg-48486	64	36	tat	tat	NOUN
mkg-48486	64	37	gag	gag	NOUN
mkg-48486	64	38	aaa	aaa	NOUN
mkg-48486	64	39	aga	aga	PROPN
mkg-48486	64	40	ttt	ttt	PROPN
mkg-48486	64	41	tag	tag	NOUN
mkg-48486	64	42	att-3	att-3	NOUN
mkg-48486	64	43	’	'	PUNCT
mkg-48486	64	44	,	,	PUNCT
mkg-48486	64	45	and	and	CCONJ
mkg-48486	64	46	sequence	sequence	NOUN
mkg-48486	64	47	to	to	PART
mkg-48486	64	48	analyze	analyze	VERB
mkg-48486	64	49	tag	tag	NOUN
mkg-48486	64	50	gta	gta	PROPN
mkg-48486	64	51	ygt	ygt	PROPN
mkg-48486	64	52	gaa	gaa	PROPN
mkg-48486	64	53	gta	gta	PROPN
mkg-48486	64	54	ggg	ggg	PROPN
mkg-48486	64	55	tag	tag	NOUN
mkg-48486	64	56	ayg	ayg	PROPN
mkg-48486	64	57	ttt	ttt	PROPN
mkg-48486	64	58	yga	yga	PROPN
mkg-48486	64	59	gag	gag	PROPN
mkg-48486	64	60	ttt	ttt	PROPN
mkg-48486	64	61	tgg	tgg	PROPN
mkg-48486	64	62	ttg	ttg	PROPN
mkg-48486	64	63	.	.	PUNCT
mkg-48486	65	1	in	in	ADP
mkg-48486	65	2	pyrosequencing	pyrosequencing	PROPN
mkg-48486	65	3	,	,	PUNCT
mkg-48486	65	4	the	the	DET
mkg-48486	65	5	reverse	reverse	ADJ
mkg-48486	65	6	primer	primer	NOUN
mkg-48486	65	7	should	should	AUX
mkg-48486	65	8	be	be	AUX
mkg-48486	65	9	labeled	label	VERB
mkg-48486	65	10	by	by	ADP
mkg-48486	65	11	biotin	biotin	NOUN
mkg-48486	65	12	.	.	PUNCT
mkg-48486	66	1	dna	dna	PROPN
mkg-48486	66	2	bisulfite	bisulfite	NOUN
mkg-48486	66	3	conversion	conversion	NOUN
mkg-48486	66	4	results	result	NOUN
mkg-48486	66	5	in	in	ADP
mkg-48486	66	6	pcr	pcr	NOUN
mkg-48486	66	7	using	use	VERB
mkg-48486	66	8	forward	forward	ADV
mkg-48486	66	9	and	and	CCONJ
mkg-48486	66	10	reverse	reverse	VERB
mkg-48486	66	11	primers	primer	NOUN
mkg-48486	66	12	that	that	PRON
mkg-48486	66	13	have	have	AUX
mkg-48486	66	14	been	be	AUX
mkg-48486	66	15	designed	design	VERB
mkg-48486	66	16	to	to	PART
mkg-48486	66	17	produce	produce	VERB
mkg-48486	66	18	dna	dna	NOUN
mkg-48486	66	19	ladder	ladder	NOUN
mkg-48486	66	20	1	1	NUM
mkg-48486	66	21	2	2	NUM
mkg-48486	66	22	3	3	NUM
mkg-48486	66	23	4	4	NUM
mkg-48486	66	24	5	5	NUM
mkg-48486	66	25	6	6	NUM
mkg-48486	66	26	7	7	NUM
mkg-48486	66	27	8	8	NUM
mkg-48486	66	28	9	9	NUM
mkg-48486	66	29	10	10	NUM
mkg-48486	66	30	11	11	NUM
mkg-48486	66	31	12	12	NUM
mkg-48486	66	32	figure	figure	NOUN
mkg-48486	66	33	2	2	NUM
mkg-48486	66	34	.	.	PUNCT
mkg-48486	66	35	electrophoresis	electrophoresis	NOUN
mkg-48486	66	36	results	result	NOUN
mkg-48486	66	37	of	of	ADP
mkg-48486	66	38	the	the	DET
mkg-48486	66	39	mthfr	mthfr	NOUN
mkg-48486	66	40	gene	gene	NOUN
mkg-48486	66	41	with	with	ADP
mkg-48486	66	42	a	a	DET
mkg-48486	66	43	product	product	NOUN
mkg-48486	66	44	length	length	NOUN
mkg-48486	66	45	of	of	ADP
mkg-48486	66	46	84	84	NUM
mkg-48486	66	47	bp	bp	NOUN
mkg-48486	66	48	.	.	PUNCT
mkg-48486	67	1	lane	lane	PROPN
mkg-48486	67	2	0	0	NUM
mkg-48486	67	3	:	:	PUNCT
mkg-48486	67	4	ladder	ladder	NOUN
mkg-48486	67	5	100	100	NUM
mkg-48486	67	6	bp	bp	PROPN
mkg-48486	67	7	,	,	PUNCT
mkg-48486	67	8	line	line	NOUN
mkg-48486	67	9	1–6	1–6	NUM
mkg-48486	67	10	:	:	PUNCT
mkg-48486	67	11	dna	dna	PROPN
mkg-48486	67	12	c1	c1	PROPN
mkg-48486	67	13	–	–	PUNCT
mkg-48486	67	14	c6	c6	PROPN
mkg-48486	67	15	,	,	PUNCT
mkg-48486	67	16	line	line	NOUN
mkg-48486	67	17	7–12	7–12	PROPN
mkg-48486	67	18	:	:	PUNCT
mkg-48486	67	19	dna	dna	PROPN
mkg-48486	67	20	n1	n1	PROPN
mkg-48486	67	21	–	–	PUNCT
mkg-48486	67	22	n6	n6	PROPN
mkg-48486	67	23	.	.	PUNCT
mkg-48486	68	1	a.	a.	NOUN
mkg-48486	68	2	view	view	NOUN
mkg-48486	68	3	of	of	ADP
mkg-48486	68	4	the	the	DET
mkg-48486	68	5	pyrogram	pyrogram	NOUN
mkg-48486	68	6	for	for	ADP
mkg-48486	68	7	patient	patient	ADJ
mkg-48486	68	8	samples	sample	NOUN
mkg-48486	68	9	(	(	PUNCT
mkg-48486	68	10	c	c	X
mkg-48486	68	11	)	)	PUNCT
mkg-48486	68	12	b.	b.	NOUN
mkg-48486	68	13	view	view	NOUN
mkg-48486	68	14	of	of	ADP
mkg-48486	68	15	the	the	DET
mkg-48486	68	16	pyrogram	pyrogram	NOUN
mkg-48486	68	17	for	for	ADP
mkg-48486	68	18	normal	normal	ADJ
mkg-48486	68	19	samples	sample	NOUN
mkg-48486	68	20	(	(	PUNCT
mkg-48486	68	21	n	n	CCONJ
mkg-48486	68	22	)	)	PUNCT
mkg-48486	68	23	figure	figure	NOUN
mkg-48486	68	24	3	3	NUM
mkg-48486	68	25	.	.	NOUN
mkg-48486	68	26	results	result	NOUN
mkg-48486	68	27	of	of	ADP
mkg-48486	68	28	mthfr	mthfr	NOUN
mkg-48486	68	29	gene	gene	NOUN
mkg-48486	68	30	pyrosequencing	pyrosequencing	NOUN
mkg-48486	68	31	.	.	PUNCT
mkg-48486	69	1	the	the	DET
mkg-48486	69	2	red	red	ADJ
mkg-48486	69	3	boxes	box	NOUN
mkg-48486	69	4	indicate	indicate	VERB
mkg-48486	69	5	the	the	DET
mkg-48486	69	6	location	location	NOUN
mkg-48486	69	7	of	of	ADP
mkg-48486	69	8	methylation	methylation	NOUN
mkg-48486	69	9	points	point	NOUN
mkg-48486	69	10	.	.	PUNCT
mkg-48486	70	1	(	(	PUNCT
mkg-48486	70	2	a	a	X
mkg-48486	70	3	)	)	PUNCT
mkg-48486	70	4	pyrogram	pyrogram	NOUN
mkg-48486	70	5	view	view	NOUN
mkg-48486	70	6	of	of	ADP
mkg-48486	70	7	sample	sample	NOUN
mkg-48486	70	8	c4	c4	NOUN
mkg-48486	70	9	(	(	PUNCT
mkg-48486	70	10	patient	patient	ADJ
mkg-48486	70	11	sample	sample	NOUN
mkg-48486	70	12	)	)	PUNCT
mkg-48486	70	13	;	;	PUNCT
mkg-48486	70	14	point	point	NOUN
mkg-48486	70	15	1	1	NUM
mkg-48486	70	16	:	:	SYM
mkg-48486	70	17	3	3	NUM
mkg-48486	70	18	%	%	NOUN
mkg-48486	70	19	,	,	PUNCT
mkg-48486	70	20	point	point	NOUN
mkg-48486	70	21	2	2	NUM
mkg-48486	70	22	:	:	SYM
mkg-48486	70	23	4	4	NUM
mkg-48486	70	24	%	%	NOUN
mkg-48486	70	25	,	,	PUNCT
mkg-48486	70	26	point	point	NOUN
mkg-48486	70	27	3	3	NUM
mkg-48486	70	28	:	:	SYM
mkg-48486	71	1	3	3	NUM
mkg-48486	71	2	%	%	NOUN
mkg-48486	71	3	,	,	PUNCT
mkg-48486	71	4	(	(	PUNCT
mkg-48486	71	5	b	b	X
mkg-48486	71	6	)	)	PUNCT
mkg-48486	71	7	pyrogram	pyrogram	NOUN
mkg-48486	71	8	view	view	NOUN
mkg-48486	71	9	of	of	ADP
mkg-48486	71	10	sample	sample	NOUN
mkg-48486	71	11	n5	n5	PROPN
mkg-48486	71	12	(	(	PUNCT
mkg-48486	71	13	normal	normal	ADJ
mkg-48486	71	14	control	control	NOUN
mkg-48486	71	15	sample	sample	NOUN
mkg-48486	71	16	)	)	PUNCT
mkg-48486	71	17	;	;	PUNCT
mkg-48486	71	18	point	point	NOUN
mkg-48486	71	19	1	1	NUM
mkg-48486	71	20	:	:	SYM
mkg-48486	71	21	2	2	NUM
mkg-48486	71	22	%	%	NOUN
mkg-48486	71	23	,	,	PUNCT
mkg-48486	71	24	point	point	NOUN
mkg-48486	71	25	2	2	NUM
mkg-48486	71	26	:	:	SYM
mkg-48486	71	27	4	4	NUM
mkg-48486	71	28	%	%	NOUN
mkg-48486	71	29	,	,	PUNCT
mkg-48486	71	30	point	point	NOUN
mkg-48486	71	31	3	3	NUM
mkg-48486	71	32	:	:	SYM
mkg-48486	71	33	0	0	NUM
mkg-48486	71	34	%	%	NOUN
mkg-48486	71	35	.	.	PUNCT
mkg-48486	72	1	copyright	copyright	NOUN
mkg-48486	72	2	©	©	ADP
mkg-48486	72	3	2024	2024	NUM
mkg-48486	72	4	dental	dental	ADJ
mkg-48486	72	5	journal	journal	NOUN
mkg-48486	72	6	(	(	PUNCT
mkg-48486	72	7	majalah	majalah	PROPN
mkg-48486	72	8	kedokteran	kedokteran	PROPN
mkg-48486	72	9	gigi	gigi	PROPN
mkg-48486	72	10	)	)	PUNCT
mkg-48486	73	1	p	p	X
mkg-48486	73	2	-	-	PUNCT
mkg-48486	73	3	issn	issn	NOUN
mkg-48486	73	4	:	:	PUNCT
mkg-48486	73	5	1978	1978	NUM
mkg-48486	73	6	-	-	SYM
mkg-48486	73	7	3728	3728	NUM
mkg-48486	73	8	;	;	PUNCT
mkg-48486	73	9	e	e	X
mkg-48486	73	10	-	-	PUNCT
mkg-48486	73	11	issn	issn	ADJ
mkg-48486	73	12	:	:	PUNCT
mkg-48486	73	13	2442	2442	NUM
mkg-48486	73	14	-	-	SYM
mkg-48486	73	15	9740	9740	NUM
mkg-48486	73	16	.	.	PUNCT
mkg-48486	74	1	accredited	accredit	VERB
mkg-48486	74	2	no	no	INTJ
mkg-48486	74	3	.	.	PROPN
mkg-48486	75	1	158	158	NUM
mkg-48486	75	2	/	/	SYM
mkg-48486	75	3	e	e	NOUN
mkg-48486	75	4	/	/	SYM
mkg-48486	75	5	kpt/2021	kpt/2021	NOUN
mkg-48486	75	6	.	.	PUNCT
mkg-48486	76	1	open	open	ADJ
mkg-48486	76	2	access	access	NOUN
mkg-48486	76	3	under	under	ADP
mkg-48486	76	4	cc	cc	NOUN
mkg-48486	76	5	-	-	PUNCT
mkg-48486	76	6	by	by	ADP
mkg-48486	76	7	-	-	PUNCT
mkg-48486	76	8	sa	sa	NOUN
mkg-48486	76	9	license	license	NOUN
mkg-48486	76	10	.	.	PUNCT
mkg-48486	77	1	available	available	ADJ
mkg-48486	77	2	at	at	ADP
mkg-48486	77	3	https://e-journal.unair.ac.id/mkg/index	https://e-journal.unair.ac.id/mkg/index	NOUN
mkg-48486	77	4	doi	doi	NOUN
mkg-48486	77	5	:	:	PUNCT
mkg-48486	77	6	10.20473	10.20473	NUM
mkg-48486	77	7	/	/	SYM
mkg-48486	77	8	j.djmkg.v57.i3.p184–188	j.djmkg.v57.i3.p184–188	NOUN
mkg-48486	77	9	https://e-journal.unair.ac.id/mkg/index	https://e-journal.unair.ac.id/mkg/index	NOUN
mkg-48486	77	10	https://doi.org/10.20473/j.djmkg.v57.i3.p184-188	https://doi.org/10.20473/j.djmkg.v57.i3.p184-188	VERB
mkg-48486	77	11	187	187	NUM
mkg-48486	77	12	maskoen	maskoen	NOUN
mkg-48486	77	13	et	et	PROPN
mkg-48486	77	14	al	al	PROPN
mkg-48486	77	15	.	.	PROPN
mkg-48486	77	16	dent	dent	PROPN
mkg-48486	77	17	.	.	PUNCT
mkg-48486	78	1	j.	j.	PROPN
mkg-48486	78	2	(	(	PUNCT
mkg-48486	78	3	majalah	majalah	PROPN
mkg-48486	78	4	kedokteran	kedokteran	PROPN
mkg-48486	78	5	gigi	gigi	PROPN
mkg-48486	78	6	)	)	PUNCT
mkg-48486	78	7	2024	2024	NUM
mkg-48486	78	8	september	september	PROPN
mkg-48486	78	9	;	;	PUNCT
mkg-48486	78	10	57(3	57(3	NUM
mkg-48486	78	11	):	):	PUNCT
mkg-48486	78	12	184–188	184–188	NUM
mkg-48486	78	13	dna	dna	NOUN
mkg-48486	78	14	strands	strand	VERB
mkg-48486	78	15	with	with	ADP
mkg-48486	78	16	a	a	DET
mkg-48486	78	17	length	length	NOUN
mkg-48486	78	18	of	of	ADP
mkg-48486	78	19	84	84	NUM
mkg-48486	78	20	bp	bp	PROPN
mkg-48486	78	21	when	when	SCONJ
mkg-48486	78	22	viewed	view	VERB
mkg-48486	78	23	on	on	ADP
mkg-48486	78	24	gel	gel	NOUN
mkg-48486	78	25	electrophoresis	electrophoresis	NOUN
mkg-48486	78	26	.	.	PUNCT
mkg-48486	79	1	in	in	ADP
mkg-48486	79	2	the	the	DET
mkg-48486	79	3	bisulfite	bisulfite	NOUN
mkg-48486	79	4	process	process	NOUN
mkg-48486	79	5	,	,	PUNCT
mkg-48486	79	6	the	the	DET
mkg-48486	79	7	c	c	PROPN
mkg-48486	79	8	base	base	NOUN
mkg-48486	79	9	(	(	PUNCT
mkg-48486	79	10	cytosine	cytosine	NOUN
mkg-48486	79	11	)	)	PUNCT
mkg-48486	79	12	is	be	AUX
mkg-48486	79	13	converted	convert	VERB
mkg-48486	79	14	to	to	ADP
mkg-48486	79	15	the	the	DET
mkg-48486	79	16	u	u	NOUN
mkg-48486	79	17	base	base	NOUN
mkg-48486	79	18	(	(	PUNCT
mkg-48486	79	19	uracil	uracil	NOUN
mkg-48486	79	20	)	)	PUNCT
mkg-48486	79	21	,	,	PUNCT
mkg-48486	79	22	while	while	SCONJ
mkg-48486	79	23	the	the	DET
mkg-48486	79	24	mc	mc	PROPN
mkg-48486	79	25	base	base	PROPN
mkg-48486	79	26	(	(	PUNCT
mkg-48486	79	27	methylated	methylate	VERB
mkg-48486	79	28	cytosine	cytosine	NOUN
mkg-48486	79	29	)	)	PUNCT
mkg-48486	79	30	remains	remain	VERB
mkg-48486	79	31	unchanged	unchanged	ADJ
mkg-48486	79	32	,	,	PUNCT
mkg-48486	79	33	so	so	SCONJ
mkg-48486	79	34	that	that	SCONJ
mkg-48486	79	35	in	in	ADP
mkg-48486	79	36	the	the	DET
mkg-48486	79	37	pcr	pcr	ADJ
mkg-48486	79	38	process	process	NOUN
mkg-48486	79	39	the	the	DET
mkg-48486	79	40	u	u	NOUN
mkg-48486	79	41	base	base	NOUN
mkg-48486	79	42	pairs	pair	NOUN
mkg-48486	79	43	with	with	ADP
mkg-48486	79	44	the	the	DET
mkg-48486	79	45	t	t	NOUN
mkg-48486	79	46	base	base	NOUN
mkg-48486	79	47	(	(	PUNCT
mkg-48486	79	48	thymine	thymine	NOUN
mkg-48486	79	49	)	)	PUNCT
mkg-48486	79	50	and	and	CCONJ
mkg-48486	79	51	the	the	DET
mkg-48486	79	52	mc	mc	PROPN
mkg-48486	79	53	base	base	NOUN
mkg-48486	79	54	pairs	pair	NOUN
mkg-48486	79	55	with	with	ADP
mkg-48486	79	56	the	the	DET
mkg-48486	79	57	c	c	PROPN
mkg-48486	79	58	base	base	NOUN
mkg-48486	79	59	.	.	PUNCT
mkg-48486	80	1	the	the	DET
mkg-48486	80	2	pcr	pcr	ADJ
mkg-48486	80	3	conditions	condition	NOUN
mkg-48486	80	4	used	use	VERB
mkg-48486	80	5	were	be	AUX
mkg-48486	80	6	initial	initial	ADJ
mkg-48486	80	7	denaturation	denaturation	NOUN
mkg-48486	80	8	at	at	ADP
mkg-48486	80	9	94	94	NUM
mkg-48486	80	10	oc	oc	NOUN
mkg-48486	80	11	,	,	PUNCT
mkg-48486	80	12	3	3	NUM
mkg-48486	80	13	minutes	minute	NOUN
mkg-48486	80	14	,	,	PUNCT
mkg-48486	80	15	thereafter	thereafter	ADV
mkg-48486	80	16	,	,	PUNCT
mkg-48486	80	17	cycling	cycle	VERB
mkg-48486	80	18	40	40	NUM
mkg-48486	80	19	times	time	NOUN
mkg-48486	80	20	:	:	PUNCT
mkg-48486	80	21	94	94	NUM
mkg-48486	80	22	oc	oc	NOUN
mkg-48486	80	23	,	,	PUNCT
mkg-48486	80	24	30	30	NUM
mkg-48486	80	25	seconds	second	NOUN
mkg-48486	80	26	;	;	PUNCT
mkg-48486	80	27	60	60	NUM
mkg-48486	80	28	oc	oc	NOUN
mkg-48486	80	29	,	,	PUNCT
mkg-48486	80	30	30	30	NUM
mkg-48486	80	31	seconds	second	NOUN
mkg-48486	80	32	;	;	PUNCT
mkg-48486	80	33	72	72	NUM
mkg-48486	80	34	oc	oc	NOUN
mkg-48486	80	35	,	,	PUNCT
mkg-48486	80	36	30	30	NUM
mkg-48486	80	37	seconds	second	NOUN
mkg-48486	80	38	.	.	PUNCT
mkg-48486	81	1	the	the	DET
mkg-48486	81	2	final	final	ADJ
mkg-48486	81	3	extension	extension	NOUN
mkg-48486	81	4	was	be	AUX
mkg-48486	81	5	72	72	NUM
mkg-48486	81	6	oc	oc	NOUN
mkg-48486	81	7	,	,	PUNCT
mkg-48486	81	8	3	3	NUM
mkg-48486	81	9	minutes	minute	NOUN
mkg-48486	81	10	.	.	PUNCT
mkg-48486	82	1	pyro	pyro	PROPN
mkg-48486	82	2	q	q	NOUN
mkg-48486	82	3	-	-	PUNCT
mkg-48486	82	4	cpg	cpg	NOUN
mkg-48486	82	5	is	be	AUX
mkg-48486	82	6	useful	useful	ADJ
mkg-48486	82	7	for	for	ADP
mkg-48486	82	8	dna	dna	PROPN
mkg-48486	82	9	methylation	methylation	NOUN
mkg-48486	82	10	studies	study	NOUN
mkg-48486	82	11	,	,	PUNCT
mkg-48486	82	12	as	as	SCONJ
mkg-48486	82	13	it	it	PRON
mkg-48486	82	14	can	can	AUX
mkg-48486	82	15	quantitatively	quantitatively	ADV
mkg-48486	82	16	measure	measure	VERB
mkg-48486	82	17	the	the	DET
mkg-48486	82	18	methylation	methylation	NOUN
mkg-48486	82	19	level	level	NOUN
mkg-48486	82	20	of	of	ADP
mkg-48486	82	21	the	the	DET
mkg-48486	82	22	cpg	cpg	PROPN
mkg-48486	82	23	island	island	NOUN
mkg-48486	82	24	region	region	NOUN
mkg-48486	82	25	.	.	PUNCT
mkg-48486	83	1	cytosine	cytosine	NOUN
mkg-48486	83	2	methylation	methylation	NOUN
mkg-48486	83	3	in	in	ADP
mkg-48486	83	4	cpg	cpg	PROPN
mkg-48486	83	5	is	be	AUX
mkg-48486	83	6	an	an	DET
mkg-48486	83	7	important	important	ADJ
mkg-48486	83	8	regulator	regulator	NOUN
mkg-48486	83	9	in	in	ADP
mkg-48486	83	10	the	the	DET
mkg-48486	83	11	process	process	NOUN
mkg-48486	83	12	of	of	ADP
mkg-48486	83	13	gene	gene	NOUN
mkg-48486	83	14	expression	expression	NOUN
mkg-48486	83	15	in	in	ADP
mkg-48486	83	16	the	the	DET
mkg-48486	83	17	human	human	ADJ
mkg-48486	83	18	genome	genome	NOUN
mkg-48486	83	19	.	.	PUNCT
mkg-48486	84	1	pyrosequencing	pyrosequencing	NOUN
mkg-48486	84	2	is	be	AUX
mkg-48486	84	3	a	a	DET
mkg-48486	84	4	useful	useful	ADJ
mkg-48486	84	5	method	method	NOUN
mkg-48486	84	6	for	for	ADP
mkg-48486	84	7	cpg	cpg	NOUN
mkg-48486	84	8	methylation	methylation	NOUN
mkg-48486	84	9	analysis	analysis	NOUN
mkg-48486	84	10	because	because	SCONJ
mkg-48486	84	11	it	it	PRON
mkg-48486	84	12	can	can	AUX
mkg-48486	84	13	measure	measure	VERB
mkg-48486	84	14	methylation	methylation	NOUN
mkg-48486	84	15	quickly	quickly	ADV
mkg-48486	84	16	and	and	CCONJ
mkg-48486	84	17	easily	easily	ADV
mkg-48486	84	18	.	.	PUNCT
mkg-48486	85	1	in	in	ADP
mkg-48486	85	2	the	the	DET
mkg-48486	85	3	pyrogram	pyrogram	NOUN
mkg-48486	85	4	produced	produce	VERB
mkg-48486	85	5	during	during	ADP
mkg-48486	85	6	the	the	DET
mkg-48486	85	7	pyrosequencing	pyrosequencing	NOUN
mkg-48486	85	8	process	process	NOUN
mkg-48486	85	9	,	,	PUNCT
mkg-48486	85	10	mc	mc	PROPN
mkg-48486	85	11	and	and	CCONJ
mkg-48486	85	12	c	c	PROPN
mkg-48486	85	13	are	be	AUX
mkg-48486	85	14	represented	represent	VERB
mkg-48486	85	15	as	as	ADP
mkg-48486	85	16	c	c	PROPN
mkg-48486	85	17	and	and	CCONJ
mkg-48486	85	18	t	t	PROPN
mkg-48486	85	19	peaks	peak	NOUN
mkg-48486	85	20	respectively	respectively	ADV
mkg-48486	85	21	.	.	PUNCT
mkg-48486	86	1	the	the	DET
mkg-48486	86	2	proportion	proportion	NOUN
mkg-48486	86	3	of	of	ADP
mkg-48486	86	4	the	the	DET
mkg-48486	86	5	peak	peak	NOUN
mkg-48486	86	6	heights	height	NOUN
mkg-48486	86	7	is	be	AUX
mkg-48486	86	8	proportional	proportional	ADJ
mkg-48486	86	9	to	to	ADP
mkg-48486	86	10	the	the	DET
mkg-48486	86	11	number	number	NOUN
mkg-48486	86	12	of	of	ADP
mkg-48486	86	13	alleles	allele	NOUN
mkg-48486	86	14	methylated	methylate	VERB
mkg-48486	86	15	at	at	ADP
mkg-48486	86	16	each	each	DET
mkg-48486	86	17	cpg	cpg	NOUN
mkg-48486	86	18	site	site	NOUN
mkg-48486	86	19	;	;	PUNCT
mkg-48486	86	20	the	the	DET
mkg-48486	86	21	number	number	NOUN
mkg-48486	86	22	of	of	ADP
mkg-48486	86	23	data	datum	NOUN
mkg-48486	86	24	calculations	calculation	NOUN
mkg-48486	86	25	is	be	AUX
mkg-48486	86	26	displayed	display	VERB
mkg-48486	86	27	as	as	ADP
mkg-48486	86	28	a	a	DET
mkg-48486	86	29	percentage	percentage	NOUN
mkg-48486	86	30	.	.	PUNCT
mkg-48486	87	1	in	in	ADP
mkg-48486	87	2	the	the	DET
mkg-48486	87	3	process	process	NOUN
mkg-48486	87	4	of	of	ADP
mkg-48486	87	5	detecting	detect	VERB
mkg-48486	87	6	mthfr	mthfr	PROPN
mkg-48486	87	7	gene	gene	NOUN
mkg-48486	87	8	methylation	methylation	NOUN
mkg-48486	87	9	,	,	PUNCT
mkg-48486	87	10	the	the	DET
mkg-48486	87	11	sequencing	sequence	VERB
mkg-48486	87	12	primers	primer	NOUN
mkg-48486	87	13	diluted	dilute	VERB
mkg-48486	87	14	with	with	ADP
mkg-48486	87	15	annealing	anneal	VERB
mkg-48486	87	16	buffer	buffer	NOUN
mkg-48486	87	17	and	and	CCONJ
mkg-48486	87	18	the	the	DET
mkg-48486	87	19	sequence	sequence	NOUN
mkg-48486	87	20	to	to	PART
mkg-48486	87	21	analyze	analyze	VERB
mkg-48486	87	22	the	the	DET
mkg-48486	87	23	sequence	sequence	NOUN
mkg-48486	87	24	must	must	AUX
mkg-48486	87	25	be	be	AUX
mkg-48486	87	26	entered	enter	VERB
mkg-48486	87	27	into	into	ADP
mkg-48486	87	28	qiagen	qiagen	PROPN
mkg-48486	87	29	’s	’s	PART
mkg-48486	87	30	pyromark	pyromark	PROPN
mkg-48486	87	31	q96	q96	PROPN
mkg-48486	87	32	software	software	NOUN
mkg-48486	87	33	.	.	PUNCT
mkg-48486	88	1	results	result	VERB
mkg-48486	88	2	the	the	DET
mkg-48486	88	3	concentration	concentration	NOUN
mkg-48486	88	4	and	and	CCONJ
mkg-48486	88	5	purity	purity	NOUN
mkg-48486	88	6	of	of	ADP
mkg-48486	88	7	dna	dna	PROPN
mkg-48486	88	8	samples	sample	NOUN
mkg-48486	88	9	from	from	ADP
mkg-48486	88	10	cl	cl	NOUN
mkg-48486	88	11	/	/	SYM
mkg-48486	88	12	p	p	NOUN
mkg-48486	88	13	sufferers	sufferer	NOUN
mkg-48486	88	14	and	and	CCONJ
mkg-48486	88	15	normal	normal	ADJ
mkg-48486	88	16	controls	control	NOUN
mkg-48486	88	17	were	be	AUX
mkg-48486	88	18	calculated	calculate	VERB
mkg-48486	88	19	using	use	VERB
mkg-48486	88	20	the	the	DET
mkg-48486	88	21	nanodrop	nanodrop	NOUN
mkg-48486	88	22	tool	tool	NOUN
mkg-48486	88	23	.	.	PUNCT
mkg-48486	89	1	dna	dna	PROPN
mkg-48486	89	2	extraction	extraction	NOUN
mkg-48486	89	3	was	be	AUX
mkg-48486	89	4	carried	carry	VERB
mkg-48486	89	5	out	out	ADP
mkg-48486	89	6	on	on	ADP
mkg-48486	89	7	all	all	DET
mkg-48486	89	8	sample	sample	NOUN
mkg-48486	89	9	groups	group	NOUN
mkg-48486	89	10	c	c	PROPN
mkg-48486	89	11	and	and	CCONJ
mkg-48486	89	12	n	n	CCONJ
mkg-48486	89	13	;	;	PUNCT
mkg-48486	89	14	after	after	ADP
mkg-48486	89	15	being	be	AUX
mkg-48486	89	16	measured	measure	VERB
mkg-48486	89	17	by	by	ADP
mkg-48486	89	18	nanodrop	nanodrop	NOUN
mkg-48486	89	19	,	,	PUNCT
mkg-48486	89	20	it	it	PRON
mkg-48486	89	21	was	be	AUX
mkg-48486	89	22	found	find	VERB
mkg-48486	89	23	that	that	SCONJ
mkg-48486	89	24	all	all	DET
mkg-48486	89	25	samples	sample	NOUN
mkg-48486	89	26	had	have	VERB
mkg-48486	89	27	a	a	DET
mkg-48486	89	28	high	high	ADJ
mkg-48486	89	29	dna	dna	NOUN
mkg-48486	89	30	concentration	concentration	NOUN
mkg-48486	89	31	of	of	ADP
mkg-48486	89	32	more	more	ADJ
mkg-48486	89	33	than	than	ADP
mkg-48486	89	34	50	50	NUM
mkg-48486	89	35	ng/µl	ng/µl	NUM
mkg-48486	89	36	.	.	PUNCT
mkg-48486	90	1	dna	dna	PROPN
mkg-48486	90	2	purity	purity	NOUN
mkg-48486	90	3	was	be	AUX
mkg-48486	90	4	also	also	ADV
mkg-48486	90	5	very	very	ADV
mkg-48486	90	6	good	good	ADJ
mkg-48486	90	7	;	;	PUNCT
mkg-48486	90	8	all	all	DET
mkg-48486	90	9	samples	sample	NOUN
mkg-48486	90	10	showed	show	VERB
mkg-48486	90	11	a	a	DET
mkg-48486	90	12	ratio	ratio	NOUN
mkg-48486	90	13	of	of	ADP
mkg-48486	90	14	260/280	260/280	PROPN
mkg-48486	90	15	,	,	PUNCT
mkg-48486	90	16	1.8	1.8	NUM
mkg-48486	90	17	(	(	PUNCT
mkg-48486	90	18	good	good	ADJ
mkg-48486	90	19	dna	dna	PROPN
mkg-48486	90	20	purity	purity	NOUN
mkg-48486	90	21	:	:	PUNCT
mkg-48486	90	22	1.7–1.8	1.7–1.8	NUM
mkg-48486	90	23	)	)	PUNCT
mkg-48486	90	24	.	.	PUNCT
mkg-48486	91	1	this	this	PRON
mkg-48486	91	2	shows	show	VERB
mkg-48486	91	3	that	that	SCONJ
mkg-48486	91	4	all	all	DET
mkg-48486	91	5	samples	sample	NOUN
mkg-48486	91	6	met	meet	VERB
mkg-48486	91	7	the	the	DET
mkg-48486	91	8	quality	quality	NOUN
mkg-48486	91	9	criteria	criterion	NOUN
mkg-48486	91	10	,	,	PUNCT
mkg-48486	91	11	so	so	SCONJ
mkg-48486	91	12	they	they	PRON
mkg-48486	91	13	were	be	AUX
mkg-48486	91	14	eligible	eligible	ADJ
mkg-48486	91	15	to	to	PART
mkg-48486	91	16	enter	enter	VERB
mkg-48486	91	17	the	the	DET
mkg-48486	91	18	next	next	ADJ
mkg-48486	91	19	stage	stage	NOUN
mkg-48486	91	20	of	of	ADP
mkg-48486	91	21	examination	examination	NOUN
mkg-48486	91	22	,	,	PUNCT
mkg-48486	91	23	namely	namely	ADV
mkg-48486	91	24	bisulfite	bisulfite	NOUN
mkg-48486	91	25	conversion	conversion	NOUN
mkg-48486	91	26	and	and	CCONJ
mkg-48486	91	27	pcr	pcr	NOUN
mkg-48486	91	28	.	.	PUNCT
mkg-48486	92	1	before	before	ADP
mkg-48486	92	2	entering	enter	VERB
mkg-48486	92	3	the	the	DET
mkg-48486	92	4	pyrosequencing	pyrosequence	VERB
mkg-48486	92	5	stage	stage	NOUN
mkg-48486	92	6	,	,	PUNCT
mkg-48486	92	7	all	all	DET
mkg-48486	92	8	samples	sample	NOUN
mkg-48486	92	9	to	to	PART
mkg-48486	92	10	be	be	AUX
mkg-48486	92	11	tested	test	VERB
mkg-48486	92	12	(	(	PUNCT
mkg-48486	92	13	both	both	PRON
mkg-48486	92	14	cl	cl	NOUN
mkg-48486	92	15	/	/	SYM
mkg-48486	92	16	p	p	NOUN
mkg-48486	92	17	patient	patient	NOUN
mkg-48486	92	18	samples	sample	NOUN
mkg-48486	92	19	and	and	CCONJ
mkg-48486	92	20	normal	normal	ADJ
mkg-48486	92	21	samples	sample	NOUN
mkg-48486	92	22	)	)	PUNCT
mkg-48486	92	23	were	be	AUX
mkg-48486	92	24	amplified	amplify	VERB
mkg-48486	92	25	with	with	ADP
mkg-48486	92	26	mthfr	mthfr	NOUN
mkg-48486	92	27	gene	gene	NOUN
mkg-48486	92	28	primers	primer	NOUN
mkg-48486	92	29	designed	design	VERB
mkg-48486	92	30	according	accord	VERB
mkg-48486	92	31	to	to	ADP
mkg-48486	92	32	the	the	DET
mkg-48486	92	33	methylation	methylation	NOUN
mkg-48486	92	34	target	target	NOUN
mkg-48486	92	35	of	of	ADP
mkg-48486	92	36	interest	interest	NOUN
mkg-48486	92	37	.	.	PUNCT
mkg-48486	93	1	the	the	DET
mkg-48486	93	2	pcr	pcr	PROPN
mkg-48486	93	3	product	product	NOUN
mkg-48486	93	4	obtained	obtain	VERB
mkg-48486	93	5	was	be	AUX
mkg-48486	93	6	84	84	NUM
mkg-48486	93	7	bp	bp	NOUN
mkg-48486	93	8	;	;	PUNCT
mkg-48486	93	9	an	an	DET
mkg-48486	93	10	overview	overview	NOUN
mkg-48486	93	11	of	of	ADP
mkg-48486	93	12	the	the	DET
mkg-48486	93	13	gel	gel	NOUN
mkg-48486	93	14	electrophoresis	electrophoresis	NOUN
mkg-48486	93	15	results	result	NOUN
mkg-48486	93	16	can	can	AUX
mkg-48486	93	17	be	be	AUX
mkg-48486	93	18	seen	see	VERB
mkg-48486	93	19	in	in	ADP
mkg-48486	93	20	figure	figure	NOUN
mkg-48486	93	21	2	2	NUM
mkg-48486	93	22	.	.	PUNCT
mkg-48486	93	23	good	good	ADJ
mkg-48486	93	24	quality	quality	NOUN
mkg-48486	93	25	pcr	pcr	NOUN
mkg-48486	93	26	products	product	NOUN
mkg-48486	93	27	entered	enter	VERB
mkg-48486	93	28	the	the	DET
mkg-48486	93	29	next	next	ADJ
mkg-48486	93	30	stage	stage	NOUN
mkg-48486	93	31	of	of	ADP
mkg-48486	93	32	examination	examination	NOUN
mkg-48486	93	33	,	,	PUNCT
mkg-48486	93	34	namely	namely	ADV
mkg-48486	93	35	methylation	methylation	NOUN
mkg-48486	93	36	detection	detection	NOUN
mkg-48486	93	37	by	by	ADP
mkg-48486	93	38	pyrosequencing	pyrosequence	VERB
mkg-48486	93	39	.	.	PUNCT
mkg-48486	94	1	the	the	DET
mkg-48486	94	2	result	result	NOUN
mkg-48486	94	3	of	of	ADP
mkg-48486	94	4	pyrosequencing	pyrosequencing	NOUN
mkg-48486	94	5	can	can	AUX
mkg-48486	94	6	be	be	AUX
mkg-48486	94	7	seen	see	VERB
mkg-48486	94	8	in	in	ADP
mkg-48486	94	9	the	the	DET
mkg-48486	94	10	form	form	NOUN
mkg-48486	94	11	of	of	ADP
mkg-48486	94	12	a	a	DET
mkg-48486	94	13	pyrogram	pyrogram	NOUN
mkg-48486	94	14	,	,	PUNCT
mkg-48486	94	15	and	and	CCONJ
mkg-48486	94	16	the	the	DET
mkg-48486	94	17	percentage	percentage	NOUN
mkg-48486	94	18	of	of	ADP
mkg-48486	94	19	methylation	methylation	NOUN
mkg-48486	94	20	in	in	ADP
mkg-48486	94	21	the	the	DET
mkg-48486	94	22	target	target	NOUN
mkg-48486	94	23	area	area	NOUN
mkg-48486	94	24	is	be	AUX
mkg-48486	94	25	shown	show	VERB
mkg-48486	94	26	.	.	PUNCT
mkg-48486	95	1	in	in	ADP
mkg-48486	95	2	figure	figure	NOUN
mkg-48486	95	3	3	3	NUM
mkg-48486	95	4	the	the	DET
mkg-48486	95	5	shape	shape	NOUN
mkg-48486	95	6	of	of	ADP
mkg-48486	95	7	the	the	DET
mkg-48486	95	8	pyrogram	pyrogram	NOUN
mkg-48486	95	9	shows	show	VERB
mkg-48486	95	10	that	that	SCONJ
mkg-48486	95	11	there	there	PRON
mkg-48486	95	12	are	be	VERB
mkg-48486	95	13	three	three	NUM
mkg-48486	95	14	methylation	methylation	NOUN
mkg-48486	95	15	points	point	NOUN
mkg-48486	95	16	in	in	ADP
mkg-48486	95	17	the	the	DET
mkg-48486	95	18	sample	sample	NOUN
mkg-48486	95	19	cl	cl	NOUN
mkg-48486	95	20	/	/	SYM
mkg-48486	95	21	p	p	X
mkg-48486	95	22	(	(	PUNCT
mkg-48486	95	23	c	c	NOUN
mkg-48486	95	24	)	)	PUNCT
mkg-48486	95	25	and	and	CCONJ
mkg-48486	95	26	the	the	DET
mkg-48486	95	27	normal	normal	ADJ
mkg-48486	95	28	sample	sample	NOUN
mkg-48486	95	29	(	(	PUNCT
mkg-48486	95	30	n	n	CCONJ
mkg-48486	95	31	)	)	PUNCT
mkg-48486	95	32	that	that	PRON
mkg-48486	95	33	can	can	AUX
mkg-48486	95	34	be	be	AUX
mkg-48486	95	35	analyzed	analyze	VERB
mkg-48486	95	36	.	.	PUNCT
mkg-48486	96	1	the	the	DET
mkg-48486	96	2	pyrosequencing	pyrosequencing	NOUN
mkg-48486	96	3	process	process	NOUN
mkg-48486	96	4	was	be	AUX
mkg-48486	96	5	successfully	successfully	ADV
mkg-48486	96	6	carried	carry	VERB
mkg-48486	96	7	out	out	ADP
mkg-48486	96	8	on	on	ADP
mkg-48486	96	9	20	20	NUM
mkg-48486	96	10	samples	sample	NOUN
mkg-48486	96	11	from	from	ADP
mkg-48486	96	12	group	group	NOUN
mkg-48486	96	13	c	c	PROPN
mkg-48486	96	14	and	and	CCONJ
mkg-48486	96	15	44	44	NUM
mkg-48486	96	16	samples	sample	NOUN
mkg-48486	96	17	from	from	ADP
mkg-48486	96	18	group	group	NOUN
mkg-48486	96	19	n.	n.	PROPN
mkg-48486	96	20	pyrosequencing	pyrosequencing	NOUN
mkg-48486	96	21	can	can	AUX
mkg-48486	96	22	detect	detect	VERB
mkg-48486	96	23	a	a	DET
mkg-48486	96	24	low	low	ADJ
mkg-48486	96	25	percentage	percentage	NOUN
mkg-48486	96	26	of	of	ADP
mkg-48486	96	27	methylation	methylation	NOUN
mkg-48486	96	28	.	.	PUNCT
mkg-48486	97	1	overall	overall	ADV
mkg-48486	97	2	,	,	PUNCT
mkg-48486	97	3	the	the	DET
mkg-48486	97	4	methylation	methylation	NOUN
mkg-48486	97	5	level	level	NOUN
mkg-48486	97	6	at	at	ADP
mkg-48486	97	7	these	these	DET
mkg-48486	97	8	three	three	NUM
mkg-48486	97	9	points	point	NOUN
mkg-48486	97	10	was	be	AUX
mkg-48486	97	11	low	low	ADJ
mkg-48486	97	12	(	(	PUNCT
mkg-48486	97	13	hypomethylation	hypomethylation	NOUN
mkg-48486	97	14	)	)	PUNCT
mkg-48486	97	15	.	.	PUNCT
mkg-48486	98	1	almost	almost	ADV
mkg-48486	98	2	all	all	PRON
mkg-48486	98	3	were	be	AUX
mkg-48486	98	4	below	below	ADP
mkg-48486	98	5	5	5	NUM
mkg-48486	98	6	%	%	NOUN
mkg-48486	98	7	,	,	PUNCT
mkg-48486	98	8	both	both	CCONJ
mkg-48486	98	9	in	in	ADP
mkg-48486	98	10	the	the	DET
mkg-48486	98	11	patient	patient	NOUN
mkg-48486	98	12	sample	sample	NOUN
mkg-48486	98	13	group	group	NOUN
mkg-48486	98	14	(	(	PUNCT
mkg-48486	98	15	c	c	NOUN
mkg-48486	98	16	)	)	PUNCT
mkg-48486	98	17	and	and	CCONJ
mkg-48486	98	18	the	the	DET
mkg-48486	98	19	normal	normal	ADJ
mkg-48486	98	20	control	control	NOUN
mkg-48486	98	21	sample	sample	NOUN
mkg-48486	98	22	(	(	PUNCT
mkg-48486	98	23	n	n	CCONJ
mkg-48486	98	24	)	)	PUNCT
mkg-48486	98	25	.	.	PUNCT
mkg-48486	99	1	the	the	DET
mkg-48486	99	2	average	average	ADJ
mkg-48486	99	3	results	result	NOUN
mkg-48486	99	4	at	at	ADP
mkg-48486	99	5	each	each	DET
mkg-48486	99	6	sample	sample	NOUN
mkg-48486	99	7	point	point	NOUN
mkg-48486	99	8	in	in	ADP
mkg-48486	99	9	groups	group	NOUN
mkg-48486	99	10	c	c	PROPN
mkg-48486	99	11	and	and	CCONJ
mkg-48486	99	12	n	n	PRON
mkg-48486	99	13	can	can	AUX
mkg-48486	99	14	be	be	AUX
mkg-48486	99	15	seen	see	VERB
mkg-48486	99	16	in	in	ADP
mkg-48486	99	17	table	table	NOUN
mkg-48486	99	18	1	1	NUM
mkg-48486	99	19	.	.	PUNCT
mkg-48486	99	20	discussion	discussion	NOUN
mkg-48486	99	21	the	the	DET
mkg-48486	99	22	methylation	methylation	NOUN
mkg-48486	99	23	point	point	NOUN
mkg-48486	99	24	at	at	ADP
mkg-48486	99	25	location	location	NOUN
mkg-48486	99	26	three	three	NUM
mkg-48486	99	27	corresponds	correspond	NOUN
mkg-48486	99	28	to	to	ADP
mkg-48486	99	29	the	the	DET
mkg-48486	99	30	data	datum	NOUN
mkg-48486	99	31	seen	see	VERB
mkg-48486	99	32	in	in	ADP
mkg-48486	99	33	table	table	NOUN
mkg-48486	99	34	1	1	NUM
mkg-48486	99	35	,	,	PUNCT
mkg-48486	99	36	i.e.	i.e.	X
mkg-48486	99	37	,	,	PUNCT
mkg-48486	99	38	the	the	DET
mkg-48486	99	39	group	group	NOUN
mkg-48486	99	40	c	c	PROPN
mkg-48486	99	41	sample	sample	NOUN
mkg-48486	99	42	has	have	VERB
mkg-48486	99	43	a	a	DET
mkg-48486	99	44	higher	high	ADJ
mkg-48486	99	45	methylation	methylation	NOUN
mkg-48486	99	46	level	level	NOUN
mkg-48486	99	47	than	than	ADP
mkg-48486	99	48	the	the	DET
mkg-48486	99	49	group	group	NOUN
mkg-48486	99	50	n	n	PRON
mkg-48486	99	51	sample	sample	NOUN
mkg-48486	99	52	.	.	PUNCT
mkg-48486	100	1	however	however	ADV
mkg-48486	100	2	,	,	PUNCT
mkg-48486	100	3	at	at	ADP
mkg-48486	100	4	point	point	NOUN
mkg-48486	100	5	1	1	NUM
mkg-48486	100	6	the	the	DET
mkg-48486	100	7	results	result	NOUN
mkg-48486	100	8	look	look	VERB
mkg-48486	100	9	different	different	ADJ
mkg-48486	100	10	to	to	PART
mkg-48486	100	11	point	point	VERB
mkg-48486	100	12	three	three	NUM
mkg-48486	100	13	,	,	PUNCT
mkg-48486	100	14	as	as	SCONJ
mkg-48486	100	15	group	group	NOUN
mkg-48486	100	16	c	c	NOUN
mkg-48486	100	17	samples	sample	NOUN
mkg-48486	100	18	have	have	VERB
mkg-48486	100	19	lower	low	ADJ
mkg-48486	100	20	levels	level	NOUN
mkg-48486	100	21	of	of	ADP
mkg-48486	100	22	methylation	methylation	NOUN
mkg-48486	100	23	than	than	ADP
mkg-48486	100	24	group	group	NOUN
mkg-48486	100	25	n.	n.	PROPN
mkg-48486	100	26	these	these	DET
mkg-48486	100	27	data	datum	NOUN
mkg-48486	100	28	do	do	AUX
mkg-48486	100	29	not	not	PART
mkg-48486	100	30	show	show	VERB
mkg-48486	100	31	a	a	DET
mkg-48486	100	32	significant	significant	ADJ
mkg-48486	100	33	difference	difference	NOUN
mkg-48486	100	34	between	between	ADP
mkg-48486	100	35	the	the	DET
mkg-48486	100	36	values	value	NOUN
mkg-48486	100	37	for	for	ADP
mkg-48486	100	38	groups	group	NOUN
mkg-48486	100	39	c	c	NOUN
mkg-48486	100	40	and	and	CCONJ
mkg-48486	100	41	n.	n.	PROPN
mkg-48486	100	42	in	in	ADP
mkg-48486	100	43	general	general	ADJ
mkg-48486	100	44	,	,	PUNCT
mkg-48486	100	45	the	the	DET
mkg-48486	100	46	percentage	percentage	NOUN
mkg-48486	100	47	of	of	ADP
mkg-48486	100	48	methylation	methylation	NOUN
mkg-48486	100	49	in	in	ADP
mkg-48486	100	50	the	the	DET
mkg-48486	100	51	two	two	NUM
mkg-48486	100	52	groups	group	NOUN
mkg-48486	100	53	was	be	AUX
mkg-48486	100	54	low	low	ADJ
mkg-48486	100	55	or	or	CCONJ
mkg-48486	100	56	hypomethylated	hypomethylate	VERB
mkg-48486	100	57	(	(	PUNCT
mkg-48486	100	58	average	average	ADV
mkg-48486	100	59	less	less	ADJ
mkg-48486	100	60	than	than	ADP
mkg-48486	100	61	5	5	NUM
mkg-48486	100	62	%	%	NOUN
mkg-48486	100	63	)	)	PUNCT
mkg-48486	100	64	.	.	PUNCT
mkg-48486	101	1	the	the	DET
mkg-48486	101	2	results	result	NOUN
mkg-48486	101	3	of	of	ADP
mkg-48486	101	4	this	this	DET
mkg-48486	101	5	study	study	NOUN
mkg-48486	101	6	show	show	VERB
mkg-48486	101	7	that	that	SCONJ
mkg-48486	101	8	all	all	DET
mkg-48486	101	9	samples	sample	NOUN
mkg-48486	101	10	examined	examine	VERB
mkg-48486	101	11	experienced	experienced	ADJ
mkg-48486	101	12	hypomethylation	hypomethylation	NOUN
mkg-48486	101	13	at	at	ADP
mkg-48486	101	14	the	the	DET
mkg-48486	101	15	target	target	NOUN
mkg-48486	101	16	point	point	NOUN
mkg-48486	101	17	of	of	ADP
mkg-48486	101	18	the	the	DET
mkg-48486	101	19	mthfr	mthfr	PROPN
mkg-48486	101	20	promoter	promoter	NOUN
mkg-48486	101	21	region	region	NOUN
mkg-48486	101	22	,	,	PUNCT
mkg-48486	101	23	so	so	SCONJ
mkg-48486	101	24	in	in	ADP
mkg-48486	101	25	this	this	DET
mkg-48486	101	26	case	case	NOUN
mkg-48486	101	27	methylation	methylation	NOUN
mkg-48486	101	28	in	in	ADP
mkg-48486	101	29	the	the	DET
mkg-48486	101	30	mthfr	mthfr	NOUN
mkg-48486	101	31	gene	gene	NOUN
mkg-48486	101	32	was	be	AUX
mkg-48486	101	33	not	not	PART
mkg-48486	101	34	a	a	DET
mkg-48486	101	35	factor	factor	NOUN
mkg-48486	101	36	causing	cause	VERB
mkg-48486	101	37	cl	cl	NOUN
mkg-48486	101	38	/	/	PUNCT
mkg-48486	101	39	p.	p.	NOUN
mkg-48486	102	1	the	the	DET
mkg-48486	102	2	results	result	NOUN
mkg-48486	102	3	are	be	AUX
mkg-48486	102	4	inconsistent	inconsistent	ADJ
mkg-48486	102	5	with	with	ADP
mkg-48486	102	6	the	the	DET
mkg-48486	102	7	hypothesis	hypothesis	NOUN
mkg-48486	102	8	that	that	SCONJ
mkg-48486	102	9	the	the	DET
mkg-48486	102	10	methylation	methylation	NOUN
mkg-48486	102	11	level	level	NOUN
mkg-48486	102	12	of	of	ADP
mkg-48486	102	13	the	the	DET
mkg-48486	102	14	cl	cl	NOUN
mkg-48486	102	15	/	/	SYM
mkg-48486	102	16	p	p	NOUN
mkg-48486	102	17	sample	sample	NOUN
mkg-48486	102	18	will	will	AUX
mkg-48486	102	19	be	be	AUX
mkg-48486	102	20	higher	high	ADJ
mkg-48486	102	21	than	than	ADP
mkg-48486	102	22	that	that	PRON
mkg-48486	102	23	of	of	ADP
mkg-48486	102	24	the	the	DET
mkg-48486	102	25	normal	normal	ADJ
mkg-48486	102	26	sample	sample	NOUN
mkg-48486	102	27	,	,	PUNCT
mkg-48486	102	28	causing	cause	VERB
mkg-48486	102	29	suppression	suppression	NOUN
mkg-48486	102	30	of	of	ADP
mkg-48486	102	31	mthfr	mthfr	NOUN
mkg-48486	102	32	gene	gene	NOUN
mkg-48486	102	33	expression	expression	NOUN
mkg-48486	102	34	and	and	CCONJ
mkg-48486	102	35	resulting	result	VERB
mkg-48486	102	36	in	in	ADP
mkg-48486	102	37	a	a	DET
mkg-48486	102	38	decrease	decrease	NOUN
mkg-48486	102	39	in	in	ADP
mkg-48486	102	40	the	the	DET
mkg-48486	102	41	activity	activity	NOUN
mkg-48486	102	42	of	of	ADP
mkg-48486	102	43	the	the	DET
mkg-48486	102	44	5,10	5,10	NUM
mkg-48486	102	45	-	-	PUNCT
mkg-48486	102	46	methylenetetrahydrofolate	methylenetetrahydrofolate	ADJ
mkg-48486	102	47	reductase	reductase	NOUN
mkg-48486	102	48	(	(	PUNCT
mkg-48486	102	49	mthfr	mthfr	NOUN
mkg-48486	102	50	)	)	PUNCT
mkg-48486	102	51	enzyme	enzyme	NOUN
mkg-48486	102	52	which	which	PRON
mkg-48486	102	53	becomes	become	VERB
mkg-48486	102	54	homocysteine	homocysteine	ADJ
mkg-48486	102	55	compound	compound	NOUN
mkg-48486	102	56	remethylation	remethylation	NOUN
mkg-48486	102	57	agents.13	agents.13	PROPN
mkg-48486	102	58	cleft	cleave	VERB
mkg-48486	102	59	lip	lip	NOUN
mkg-48486	102	60	and	and	CCONJ
mkg-48486	102	61	palate	palate	VERB
mkg-48486	102	62	is	be	AUX
mkg-48486	102	63	a	a	DET
mkg-48486	102	64	phenomenon	phenomenon	NOUN
mkg-48486	102	65	whereby	whereby	SCONJ
mkg-48486	102	66	the	the	DET
mkg-48486	102	67	tissues	tissue	NOUN
mkg-48486	102	68	fail	fail	VERB
mkg-48486	102	69	to	to	PART
mkg-48486	102	70	cover	cover	VERB
mkg-48486	102	71	facial	facial	ADJ
mkg-48486	102	72	areas	area	NOUN
mkg-48486	102	73	,	,	PUNCT
mkg-48486	102	74	and	and	CCONJ
mkg-48486	102	75	it	it	PRON
mkg-48486	102	76	is	be	AUX
mkg-48486	102	77	thought	think	VERB
mkg-48486	102	78	to	to	PART
mkg-48486	102	79	have	have	VERB
mkg-48486	102	80	a	a	DET
mkg-48486	102	81	relationship	relationship	NOUN
mkg-48486	102	82	with	with	ADP
mkg-48486	102	83	vitamin	vitamin	NOUN
mkg-48486	102	84	levels	level	NOUN
mkg-48486	102	85	and	and	CCONJ
mkg-48486	102	86	genetic	genetic	ADJ
mkg-48486	102	87	factors.14	factors.14	NOUN
mkg-48486	102	88	a	a	DET
mkg-48486	102	89	study	study	NOUN
mkg-48486	102	90	of	of	ADP
mkg-48486	102	91	mthfr	mthfr	PROPN
mkg-48486	102	92	gene	gene	NOUN
mkg-48486	102	93	polymorphism	polymorphism	NOUN
mkg-48486	102	94	showed	show	VERB
mkg-48486	102	95	that	that	SCONJ
mkg-48486	102	96	patients	patient	NOUN
mkg-48486	102	97	with	with	ADP
mkg-48486	102	98	the	the	DET
mkg-48486	102	99	c	c	PROPN
mkg-48486	102	100	/	/	SYM
mkg-48486	102	101	t	t	PROPN
mkg-48486	102	102	genotype	genotype	NOUN
mkg-48486	102	103	with	with	ADP
mkg-48486	102	104	low	low	ADJ
mkg-48486	102	105	levels	level	NOUN
mkg-48486	102	106	of	of	ADP
mkg-48486	102	107	folic	folic	ADJ
mkg-48486	102	108	acid	acid	NOUN
mkg-48486	102	109	had	have	VERB
mkg-48486	102	110	higher	high	ADJ
mkg-48486	102	111	rates	rate	NOUN
mkg-48486	102	112	of	of	ADP
mkg-48486	102	113	chromosomal	chromosomal	ADJ
mkg-48486	102	114	damage	damage	NOUN
mkg-48486	102	115	and	and	CCONJ
mkg-48486	102	116	heterochromatin	heterochromatin	NOUN
mkg-48486	102	117	dimethylation	dimethylation	NOUN
mkg-48486	102	118	-	-	PUNCT
mkg-48486	102	119	related	relate	VERB
mkg-48486	102	120	gene	gene	NOUN
mkg-48486	102	121	variation.15	variation.15	ADP
mkg-48486	102	122	another	another	DET
mkg-48486	102	123	study	study	NOUN
mkg-48486	102	124	showed	show	VERB
mkg-48486	102	125	that	that	SCONJ
mkg-48486	102	126	people	people	NOUN
mkg-48486	102	127	with	with	ADP
mkg-48486	102	128	cl	cl	NOUN
mkg-48486	102	129	/	/	SYM
mkg-48486	102	130	p	p	NOUN
mkg-48486	102	131	had	have	VERB
mkg-48486	102	132	lower	low	ADJ
mkg-48486	102	133	levels	level	NOUN
mkg-48486	102	134	of	of	ADP
mkg-48486	102	135	folic	folic	ADJ
mkg-48486	102	136	acid	acid	NOUN
mkg-48486	102	137	and	and	CCONJ
mkg-48486	102	138	vitamin	vitamin	NOUN
mkg-48486	102	139	b12	b12	NOUN
mkg-48486	102	140	,	,	PUNCT
mkg-48486	102	141	as	as	ADV
mkg-48486	102	142	well	well	ADV
mkg-48486	102	143	as	as	ADP
mkg-48486	102	144	higher	high	ADJ
mkg-48486	102	145	levels	level	NOUN
mkg-48486	102	146	of	of	ADP
mkg-48486	102	147	homocysteine	homocysteine	NOUN
mkg-48486	102	148	,	,	PUNCT
mkg-48486	102	149	compared	compare	VERB
mkg-48486	102	150	to	to	ADP
mkg-48486	102	151	normal	normal	ADJ
mkg-48486	102	152	controls.16,17	controls.16,17	ADJ
mkg-48486	102	153	homocysteine	homocysteine	NOUN
mkg-48486	102	154	accumulation	accumulation	NOUN
mkg-48486	102	155	can	can	AUX
mkg-48486	102	156	cause	cause	VERB
mkg-48486	102	157	a	a	DET
mkg-48486	102	158	decrease	decrease	NOUN
mkg-48486	102	159	in	in	ADP
mkg-48486	102	160	transcription	transcription	NOUN
mkg-48486	102	161	levels	level	NOUN
mkg-48486	102	162	in	in	ADP
mkg-48486	102	163	endothelial	endothelial	ADJ
mkg-48486	102	164	cells	cell	NOUN
mkg-48486	102	165	.	.	PUNCT
mkg-48486	103	1	the	the	DET
mkg-48486	103	2	mechanism	mechanism	NOUN
mkg-48486	103	3	for	for	ADP
mkg-48486	103	4	decreasing	decrease	VERB
mkg-48486	103	5	transcription	transcription	NOUN
mkg-48486	103	6	occurs	occur	VERB
mkg-48486	103	7	in	in	ADP
mkg-48486	103	8	the	the	DET
mkg-48486	103	9	promoter	promoter	NOUN
mkg-48486	103	10	region	region	NOUN
mkg-48486	103	11	by	by	ADP
mkg-48486	103	12	causing	cause	VERB
mkg-48486	103	13	the	the	DET
mkg-48486	103	14	demethylation	demethylation	NOUN
mkg-48486	103	15	of	of	ADP
mkg-48486	103	16	proteins	protein	NOUN
mkg-48486	103	17	associated	associate	VERB
mkg-48486	103	18	with	with	ADP
mkg-48486	103	19	the	the	DET
mkg-48486	103	20	cpg	cpg	NOUN
mkg-48486	103	21	region	region	NOUN
mkg-48486	103	22	,	,	PUNCT
mkg-48486	103	23	resulting	result	VERB
mkg-48486	103	24	in	in	ADP
mkg-48486	103	25	the	the	DET
mkg-48486	103	26	acetylation	acetylation	NOUN
mkg-48486	103	27	of	of	ADP
mkg-48486	103	28	histone	histone	NOUN
mkg-48486	103	29	proteins	protein	NOUN
mkg-48486	103	30	which	which	PRON
mkg-48486	103	31	play	play	VERB
mkg-48486	103	32	a	a	DET
mkg-48486	103	33	role	role	NOUN
mkg-48486	103	34	in	in	ADP
mkg-48486	103	35	the	the	DET
mkg-48486	103	36	process	process	NOUN
mkg-48486	103	37	of	of	ADP
mkg-48486	103	38	chromatin	chromatin	NOUN
mkg-48486	103	39	transcription.18	transcription.18	PROPN
mkg-48486	103	40	as	as	ADP
mkg-48486	103	41	a	a	DET
mkg-48486	103	42	result	result	NOUN
mkg-48486	103	43	,	,	PUNCT
mkg-48486	103	44	the	the	DET
mkg-48486	103	45	accumulation	accumulation	NOUN
mkg-48486	103	46	of	of	ADP
mkg-48486	103	47	homocysteine	homocysteine	NOUN
mkg-48486	103	48	can	can	AUX
mkg-48486	103	49	lead	lead	VERB
mkg-48486	103	50	to	to	ADP
mkg-48486	103	51	the	the	DET
mkg-48486	103	52	formation	formation	NOUN
mkg-48486	103	53	of	of	ADP
mkg-48486	103	54	orofacial	orofacial	ADJ
mkg-48486	103	55	clefts	cleft	NOUN
mkg-48486	103	56	during	during	ADP
mkg-48486	103	57	development	development	NOUN
mkg-48486	103	58	.	.	PUNCT
mkg-48486	104	1	the	the	DET
mkg-48486	104	2	combination	combination	NOUN
mkg-48486	104	3	of	of	ADP
mkg-48486	104	4	accumulation	accumulation	NOUN
mkg-48486	104	5	of	of	ADP
mkg-48486	104	6	homocysteine	homocysteine	NOUN
mkg-48486	104	7	and	and	CCONJ
mkg-48486	104	8	deficiency	deficiency	NOUN
mkg-48486	104	9	in	in	ADP
mkg-48486	104	10	folate	folate	NOUN
mkg-48486	104	11	metabolism	metabolism	NOUN
mkg-48486	104	12	can	can	AUX
mkg-48486	104	13	lead	lead	VERB
mkg-48486	104	14	to	to	ADP
mkg-48486	104	15	various	various	ADJ
mkg-48486	104	16	table	table	NOUN
mkg-48486	104	17	1	1	NUM
mkg-48486	104	18	.	.	PUNCT
mkg-48486	104	19	average	average	ADJ
mkg-48486	104	20	percentage	percentage	NOUN
mkg-48486	104	21	value	value	NOUN
mkg-48486	104	22	of	of	ADP
mkg-48486	104	23	mthfr	mthfr	PROPN
mkg-48486	104	24	gene	gene	NOUN
mkg-48486	104	25	methylation	methylation	NOUN
mkg-48486	104	26	group	group	NOUN
mkg-48486	104	27	of	of	ADP
mkg-48486	104	28	sample	sample	NOUN
mkg-48486	104	29	methylation	methylation	NOUN
mkg-48486	104	30	percentage	percentage	NOUN
mkg-48486	104	31	(	(	PUNCT
mkg-48486	104	32	%	%	NOUN
mkg-48486	104	33	)	)	PUNCT
mkg-48486	104	34	point	point	NOUN
mkg-48486	105	1	1	1	NUM
mkg-48486	105	2	point	point	NOUN
mkg-48486	105	3	2	2	NUM
mkg-48486	105	4	point	point	NOUN
mkg-48486	105	5	3	3	NUM
mkg-48486	105	6	patient	patient	NOUN
mkg-48486	105	7	sample	sample	NOUN
mkg-48486	105	8	(	(	PUNCT
mkg-48486	105	9	c	c	NOUN
mkg-48486	105	10	)	)	PUNCT
mkg-48486	105	11	1.95	1.95	NUM
mkg-48486	105	12	3.29	3.29	NUM
mkg-48486	105	13	2.15	2.15	NUM
mkg-48486	105	14	normal	normal	ADJ
mkg-48486	105	15	sample	sample	NOUN
mkg-48486	105	16	(	(	PUNCT
mkg-48486	105	17	n	n	CCONJ
mkg-48486	105	18	)	)	PUNCT
mkg-48486	105	19	2.15	2.15	NUM
mkg-48486	105	20	3.29	3.29	NUM
mkg-48486	105	21	1.90	1.90	NUM
mkg-48486	105	22	copyright	copyright	NOUN
mkg-48486	105	23	©	©	ADP
mkg-48486	105	24	2024	2024	NUM
mkg-48486	105	25	dental	dental	ADJ
mkg-48486	105	26	journal	journal	NOUN
mkg-48486	105	27	(	(	PUNCT
mkg-48486	105	28	majalah	majalah	PROPN
mkg-48486	105	29	kedokteran	kedokteran	PROPN
mkg-48486	105	30	gigi	gigi	PROPN
mkg-48486	105	31	)	)	PUNCT
mkg-48486	105	32	p	p	X
mkg-48486	105	33	-	-	PUNCT
mkg-48486	105	34	issn	issn	NOUN
mkg-48486	105	35	:	:	PUNCT
mkg-48486	105	36	1978	1978	NUM
mkg-48486	105	37	-	-	SYM
mkg-48486	105	38	3728	3728	NUM
mkg-48486	105	39	;	;	PUNCT
mkg-48486	105	40	e	e	X
mkg-48486	105	41	-	-	PUNCT
mkg-48486	105	42	issn	issn	ADJ
mkg-48486	105	43	:	:	PUNCT
mkg-48486	105	44	2442	2442	NUM
mkg-48486	105	45	-	-	SYM
mkg-48486	105	46	9740	9740	NUM
mkg-48486	105	47	.	.	PUNCT
mkg-48486	106	1	accredited	accredit	VERB
mkg-48486	106	2	no	no	INTJ
mkg-48486	106	3	.	.	PROPN
mkg-48486	107	1	158	158	NUM
mkg-48486	107	2	/	/	SYM
mkg-48486	107	3	e	e	NOUN
mkg-48486	107	4	/	/	SYM
mkg-48486	107	5	kpt/2021	kpt/2021	NOUN
mkg-48486	107	6	.	.	PUNCT
mkg-48486	108	1	open	open	ADJ
mkg-48486	108	2	access	access	NOUN
mkg-48486	108	3	under	under	ADP
mkg-48486	108	4	cc	cc	NOUN
mkg-48486	108	5	-	-	PUNCT
mkg-48486	108	6	by	by	ADP
mkg-48486	108	7	-	-	PUNCT
mkg-48486	108	8	sa	sa	NOUN
mkg-48486	108	9	license	license	NOUN
mkg-48486	108	10	.	.	PUNCT
mkg-48486	109	1	available	available	ADJ
mkg-48486	109	2	at	at	ADP
mkg-48486	109	3	https://e-journal.unair.ac.id/mkg/index	https://e-journal.unair.ac.id/mkg/index	NOUN
mkg-48486	109	4	doi	doi	NOUN
mkg-48486	109	5	:	:	PUNCT
mkg-48486	109	6	10.20473	10.20473	NUM
mkg-48486	109	7	/	/	SYM
mkg-48486	109	8	j.djmkg.v57.i3.p184–188	j.djmkg.v57.i3.p184–188	NOUN
mkg-48486	109	9	https://e-journal.unair.ac.id/mkg/index	https://e-journal.unair.ac.id/mkg/index	NOUN
mkg-48486	109	10	https://doi.org/10.20473/j.djmkg.v57.i3.p184-188	https://doi.org/10.20473/j.djmkg.v57.i3.p184-188	VERB
mkg-48486	109	11	188maskoen	188maskoen	PROPN
mkg-48486	109	12	et	et	PROPN
mkg-48486	109	13	al	al	PROPN
mkg-48486	109	14	.	.	PROPN
mkg-48486	109	15	dent	dent	PROPN
mkg-48486	109	16	.	.	PUNCT
mkg-48486	110	1	j.	j.	PROPN
mkg-48486	110	2	(	(	PUNCT
mkg-48486	110	3	majalah	majalah	PROPN
mkg-48486	110	4	kedokteran	kedokteran	PROPN
mkg-48486	110	5	gigi	gigi	PROPN
mkg-48486	110	6	)	)	PUNCT
mkg-48486	110	7	2024	2024	NUM
mkg-48486	110	8	september	september	PROPN
mkg-48486	110	9	;	;	PUNCT
mkg-48486	110	10	57(3	57(3	NUM
mkg-48486	110	11	):	):	PUNCT
mkg-48486	110	12	184–188	184–188	NUM
mkg-48486	110	13	disorders	disorder	NOUN
mkg-48486	110	14	such	such	ADJ
mkg-48486	110	15	as	as	ADP
mkg-48486	110	16	neurodegenerative	neurodegenerative	ADJ
mkg-48486	110	17	diseases	disease	NOUN
mkg-48486	110	18	,	,	PUNCT
mkg-48486	110	19	osteoporosis	osteoporosis	NOUN
mkg-48486	110	20	,	,	PUNCT
mkg-48486	110	21	cancer	cancer	NOUN
mkg-48486	110	22	,	,	PUNCT
mkg-48486	110	23	heart	heart	NOUN
mkg-48486	110	24	disease	disease	NOUN
mkg-48486	110	25	,	,	PUNCT
mkg-48486	110	26	and	and	CCONJ
mkg-48486	110	27	cleft	cleave	VERB
mkg-48486	110	28	lips.19	lips.19	PRON
mkg-48486	110	29	the	the	DET
mkg-48486	110	30	results	result	NOUN
mkg-48486	110	31	of	of	ADP
mkg-48486	110	32	this	this	DET
mkg-48486	110	33	study	study	NOUN
mkg-48486	110	34	show	show	VERB
mkg-48486	110	35	that	that	SCONJ
mkg-48486	110	36	cl	cl	NOUN
mkg-48486	110	37	/	/	SYM
mkg-48486	110	38	p	p	PRON
mkg-48486	110	39	was	be	AUX
mkg-48486	110	40	not	not	PART
mkg-48486	110	41	caused	cause	VERB
mkg-48486	110	42	by	by	ADP
mkg-48486	110	43	methylation	methylation	NOUN
mkg-48486	110	44	at	at	ADP
mkg-48486	110	45	the	the	DET
mkg-48486	110	46	three	three	NUM
mkg-48486	110	47	points	point	NOUN
mkg-48486	110	48	of	of	ADP
mkg-48486	110	49	the	the	DET
mkg-48486	110	50	promoter	promoter	NOUN
mkg-48486	110	51	region	region	NOUN
mkg-48486	110	52	of	of	ADP
mkg-48486	110	53	the	the	DET
mkg-48486	110	54	mthfr	mthfr	PROPN
mkg-48486	110	55	gene	gene	NOUN
mkg-48486	110	56	,	,	PUNCT
mkg-48486	110	57	coordinates	coordinate	VERB
mkg-48486	110	58	11,805,507–11,805,529	11,805,507–11,805,529	NUM
mkg-48486	110	59	,	,	PUNCT
mkg-48486	110	60	because	because	SCONJ
mkg-48486	110	61	all	all	DET
mkg-48486	110	62	samples	sample	NOUN
mkg-48486	110	63	showed	show	VERB
mkg-48486	110	64	hypomethylation	hypomethylation	NOUN
mkg-48486	110	65	at	at	ADP
mkg-48486	110	66	the	the	DET
mkg-48486	110	67	points	point	NOUN
mkg-48486	110	68	examined	examine	VERB
mkg-48486	110	69	.	.	PUNCT
mkg-48486	111	1	cases	case	NOUN
mkg-48486	111	2	of	of	ADP
mkg-48486	111	3	cl	cl	NOUN
mkg-48486	111	4	/	/	SYM
mkg-48486	111	5	p	p	NOUN
mkg-48486	111	6	can	can	AUX
mkg-48486	111	7	be	be	AUX
mkg-48486	111	8	caused	cause	VERB
mkg-48486	111	9	by	by	ADP
mkg-48486	111	10	other	other	ADJ
mkg-48486	111	11	factors	factor	NOUN
mkg-48486	111	12	(	(	PUNCT
mkg-48486	111	13	multifactorial	multifactorial	ADJ
mkg-48486	111	14	)	)	PUNCT
mkg-48486	111	15	,	,	PUNCT
mkg-48486	111	16	so	so	SCONJ
mkg-48486	111	17	research	research	NOUN
mkg-48486	111	18	on	on	ADP
mkg-48486	111	19	the	the	DET
mkg-48486	111	20	causes	cause	NOUN
mkg-48486	111	21	of	of	ADP
mkg-48486	111	22	cl	cl	NOUN
mkg-48486	111	23	/	/	SYM
mkg-48486	111	24	p	p	NOUN
mkg-48486	111	25	needs	need	VERB
mkg-48486	111	26	to	to	PART
mkg-48486	111	27	be	be	AUX
mkg-48486	111	28	continued	continue	VERB
mkg-48486	111	29	.	.	PUNCT
mkg-48486	112	1	much	much	ADJ
mkg-48486	112	2	evidence	evidence	NOUN
mkg-48486	112	3	suggests	suggest	VERB
mkg-48486	112	4	that	that	SCONJ
mkg-48486	112	5	mthfr	mthfr	PROPN
mkg-48486	112	6	hypermethylation	hypermethylation	NOUN
mkg-48486	112	7	is	be	AUX
mkg-48486	112	8	a	a	DET
mkg-48486	112	9	risk	risk	NOUN
mkg-48486	112	10	factor	factor	NOUN
mkg-48486	112	11	for	for	ADP
mkg-48486	112	12	various	various	ADJ
mkg-48486	112	13	disease	disease	NOUN
mkg-48486	112	14	disorders	disorder	NOUN
mkg-48486	112	15	in	in	ADP
mkg-48486	112	16	humans.10,20	humans.10,20	NOUN
mkg-48486	112	17	in	in	ADP
mkg-48486	112	18	this	this	DET
mkg-48486	112	19	study	study	NOUN
mkg-48486	112	20	,	,	PUNCT
mkg-48486	112	21	only	only	ADJ
mkg-48486	112	22	methylation	methylation	NOUN
mkg-48486	112	23	levels	level	NOUN
mkg-48486	112	24	were	be	AUX
mkg-48486	112	25	detected	detect	VERB
mkg-48486	112	26	at	at	ADP
mkg-48486	112	27	three	three	NUM
mkg-48486	112	28	methylation	methylation	NOUN
mkg-48486	112	29	points	point	NOUN
mkg-48486	112	30	in	in	ADP
mkg-48486	112	31	the	the	DET
mkg-48486	112	32	promoter	promoter	NOUN
mkg-48486	112	33	region	region	NOUN
mkg-48486	112	34	of	of	ADP
mkg-48486	112	35	the	the	DET
mkg-48486	112	36	mthfr	mthfr	PROPN
mkg-48486	112	37	gene	gene	NOUN
mkg-48486	112	38	(	(	PUNCT
mkg-48486	112	39	coordinates	coordinate	NOUN
mkg-48486	112	40	11,805,507–11,805,529	11,805,507–11,805,529	NUM
mkg-48486	112	41	)	)	PUNCT
mkg-48486	112	42	,	,	PUNCT
mkg-48486	112	43	so	so	ADV
mkg-48486	112	44	further	further	ADJ
mkg-48486	112	45	research	research	NOUN
mkg-48486	112	46	is	be	AUX
mkg-48486	112	47	needed	need	VERB
mkg-48486	112	48	to	to	PART
mkg-48486	112	49	determine	determine	VERB
mkg-48486	112	50	the	the	DET
mkg-48486	112	51	factors	factor	NOUN
mkg-48486	112	52	causing	cause	VERB
mkg-48486	112	53	the	the	DET
mkg-48486	112	54	decrease	decrease	NOUN
mkg-48486	112	55	in	in	ADP
mkg-48486	112	56	mthfr	mthfr	NOUN
mkg-48486	112	57	gene	gene	NOUN
mkg-48486	112	58	expression	expression	NOUN
mkg-48486	112	59	.	.	PUNCT
mkg-48486	113	1	further	further	ADJ
mkg-48486	113	2	research	research	NOUN
mkg-48486	113	3	could	could	AUX
mkg-48486	113	4	be	be	AUX
mkg-48486	113	5	carried	carry	VERB
mkg-48486	113	6	out	out	ADP
mkg-48486	113	7	to	to	PART
mkg-48486	113	8	detect	detect	VERB
mkg-48486	113	9	methylation	methylation	NOUN
mkg-48486	113	10	at	at	ADP
mkg-48486	113	11	different	different	ADJ
mkg-48486	113	12	locations	location	NOUN
mkg-48486	113	13	on	on	ADP
mkg-48486	113	14	the	the	DET
mkg-48486	113	15	mthfr	mthfr	NOUN
mkg-48486	113	16	gene	gene	NOUN
mkg-48486	113	17	promoter	promoter	NOUN
mkg-48486	113	18	or	or	CCONJ
mkg-48486	113	19	to	to	PART
mkg-48486	113	20	look	look	VERB
mkg-48486	113	21	for	for	ADP
mkg-48486	113	22	mutations	mutation	NOUN
mkg-48486	113	23	or	or	CCONJ
mkg-48486	113	24	methylation	methylation	NOUN
mkg-48486	113	25	in	in	ADP
mkg-48486	113	26	other	other	ADJ
mkg-48486	113	27	genes	gene	NOUN
mkg-48486	113	28	involved	involve	VERB
mkg-48486	113	29	in	in	ADP
mkg-48486	113	30	the	the	DET
mkg-48486	113	31	phosphate	phosphate	ADJ
mkg-48486	113	32	cycle	cycle	NOUN
mkg-48486	113	33	,	,	PUNCT
mkg-48486	113	34	for	for	ADP
mkg-48486	113	35	example	example	NOUN
mkg-48486	113	36	,	,	PUNCT
mkg-48486	113	37	the	the	DET
mkg-48486	113	38	dnmt	dnmt	NOUN
mkg-48486	113	39	gene.21	gene.21	PROPN
mkg-48486	113	40	this	this	DET
mkg-48486	113	41	study	study	NOUN
mkg-48486	113	42	used	use	VERB
mkg-48486	113	43	a	a	DET
mkg-48486	113	44	limited	limited	ADJ
mkg-48486	113	45	number	number	NOUN
mkg-48486	113	46	of	of	ADP
mkg-48486	113	47	patient	patient	ADJ
mkg-48486	113	48	samples	sample	NOUN
mkg-48486	113	49	.	.	PUNCT
mkg-48486	114	1	due	due	ADP
mkg-48486	114	2	to	to	ADP
mkg-48486	114	3	this	this	DET
mkg-48486	114	4	limitation	limitation	NOUN
mkg-48486	114	5	,	,	PUNCT
mkg-48486	114	6	more	more	ADJ
mkg-48486	114	7	cases	case	NOUN
mkg-48486	114	8	are	be	AUX
mkg-48486	114	9	needed	need	VERB
mkg-48486	114	10	.	.	PUNCT
mkg-48486	115	1	in	in	ADP
mkg-48486	115	2	addition	addition	NOUN
mkg-48486	115	3	,	,	PUNCT
mkg-48486	115	4	the	the	DET
mkg-48486	115	5	pyrosequencing	pyrosequencing	NOUN
mkg-48486	115	6	method	method	NOUN
mkg-48486	115	7	can	can	AUX
mkg-48486	115	8	only	only	ADV
mkg-48486	115	9	read	read	VERB
mkg-48486	115	10	fewer	few	ADJ
mkg-48486	115	11	than	than	ADP
mkg-48486	115	12	300	300	NUM
mkg-48486	115	13	bp	bp	NOUN
mkg-48486	115	14	;	;	PUNCT
mkg-48486	115	15	therefore	therefore	ADV
mkg-48486	115	16	,	,	PUNCT
mkg-48486	115	17	examining	examine	VERB
mkg-48486	115	18	methylation	methylation	NOUN
mkg-48486	115	19	at	at	ADP
mkg-48486	115	20	different	different	ADJ
mkg-48486	115	21	locations	location	NOUN
mkg-48486	115	22	of	of	ADP
mkg-48486	115	23	the	the	DET
mkg-48486	115	24	mthfr	mthfr	PROPN
mkg-48486	115	25	gene	gene	NOUN
mkg-48486	115	26	promoter	promoter	NOUN
mkg-48486	115	27	is	be	AUX
mkg-48486	115	28	required	require	VERB
mkg-48486	115	29	.	.	PUNCT
mkg-48486	116	1	from	from	ADP
mkg-48486	116	2	the	the	DET
mkg-48486	116	3	results	result	NOUN
mkg-48486	116	4	,	,	PUNCT
mkg-48486	116	5	it	it	PRON
mkg-48486	116	6	can	can	AUX
mkg-48486	116	7	be	be	AUX
mkg-48486	116	8	concluded	conclude	VERB
mkg-48486	116	9	that	that	SCONJ
mkg-48486	116	10	detecting	detect	VERB
mkg-48486	116	11	and	and	CCONJ
mkg-48486	116	12	examining	examine	VERB
mkg-48486	116	13	mthfr	mthfr	PROPN
mkg-48486	116	14	gene	gene	NOUN
mkg-48486	116	15	methylation	methylation	NOUN
mkg-48486	116	16	in	in	ADP
mkg-48486	116	17	cl	cl	NOUN
mkg-48486	116	18	/	/	SYM
mkg-48486	116	19	p	p	NOUN
mkg-48486	116	20	samples	sample	NOUN
mkg-48486	116	21	can	can	AUX
mkg-48486	116	22	be	be	AUX
mkg-48486	116	23	successfully	successfully	ADV
mkg-48486	116	24	carried	carry	VERB
mkg-48486	116	25	out	out	ADP
mkg-48486	116	26	using	use	VERB
mkg-48486	116	27	the	the	DET
mkg-48486	116	28	pyrosequencing	pyrosequencing	NOUN
mkg-48486	116	29	method	method	NOUN
mkg-48486	116	30	.	.	PUNCT
mkg-48486	117	1	pyrosequencing	pyrosequence	VERB
mkg-48486	117	2	can	can	AUX
mkg-48486	117	3	detect	detect	VERB
mkg-48486	117	4	low	low	ADJ
mkg-48486	117	5	levels	level	NOUN
mkg-48486	117	6	of	of	ADP
mkg-48486	117	7	methylation	methylation	NOUN
mkg-48486	117	8	,	,	PUNCT
mkg-48486	117	9	demonstrating	demonstrate	VERB
mkg-48486	117	10	that	that	SCONJ
mkg-48486	117	11	this	this	DET
mkg-48486	117	12	method	method	NOUN
mkg-48486	117	13	is	be	AUX
mkg-48486	117	14	very	very	ADV
mkg-48486	117	15	sensitive	sensitive	ADJ
mkg-48486	117	16	and	and	CCONJ
mkg-48486	117	17	accurate	accurate	ADJ
mkg-48486	117	18	.	.	PUNCT
mkg-48486	118	1	quantitative	quantitative	ADJ
mkg-48486	118	2	data	datum	NOUN
mkg-48486	118	3	in	in	ADP
mkg-48486	118	4	the	the	DET
mkg-48486	118	5	form	form	NOUN
mkg-48486	118	6	of	of	ADP
mkg-48486	118	7	percentages	percentage	NOUN
mkg-48486	118	8	can	can	AUX
mkg-48486	118	9	be	be	AUX
mkg-48486	118	10	obtained	obtain	VERB
mkg-48486	118	11	with	with	ADP
mkg-48486	118	12	this	this	DET
mkg-48486	118	13	method	method	NOUN
mkg-48486	118	14	,	,	PUNCT
mkg-48486	118	15	in	in	ADP
mkg-48486	118	16	contrast	contrast	NOUN
mkg-48486	118	17	to	to	ADP
mkg-48486	118	18	methods	method	NOUN
mkg-48486	118	19	that	that	PRON
mkg-48486	118	20	only	only	ADV
mkg-48486	118	21	use	use	VERB
mkg-48486	118	22	pcr	pcr	NOUN
mkg-48486	118	23	and	and	CCONJ
mkg-48486	118	24	electrophoresis	electrophoresis	NOUN
mkg-48486	118	25	.	.	PUNCT
mkg-48486	119	1	the	the	DET
mkg-48486	119	2	conclusion	conclusion	NOUN
mkg-48486	119	3	that	that	PRON
mkg-48486	119	4	can	can	AUX
mkg-48486	119	5	be	be	AUX
mkg-48486	119	6	drawn	draw	VERB
mkg-48486	119	7	is	be	AUX
mkg-48486	119	8	that	that	SCONJ
mkg-48486	119	9	in	in	ADP
mkg-48486	119	10	all	all	DET
mkg-48486	119	11	samples	sample	NOUN
mkg-48486	119	12	examined	examine	VERB
mkg-48486	119	13	,	,	PUNCT
mkg-48486	119	14	no	no	DET
mkg-48486	119	15	methylation	methylation	NOUN
mkg-48486	119	16	occurs	occur	VERB
mkg-48486	119	17	in	in	ADP
mkg-48486	119	18	the	the	DET
mkg-48486	119	19	promoter	promoter	NOUN
mkg-48486	119	20	of	of	ADP
mkg-48486	119	21	the	the	DET
mkg-48486	119	22	mthfr	mthfr	PROPN
mkg-48486	119	23	gene	gene	NOUN
mkg-48486	119	24	with	with	ADP
mkg-48486	119	25	coordinates	coordinate	NOUN
mkg-48486	119	26	11,805,507–11,805,529	11,805,507–11,805,529	NUM
mkg-48486	119	27	.	.	PUNCT
mkg-48486	120	1	therefore	therefore	ADV
mkg-48486	120	2	,	,	PUNCT
mkg-48486	120	3	in	in	ADP
mkg-48486	120	4	this	this	DET
mkg-48486	120	5	case	case	NOUN
mkg-48486	120	6	,	,	PUNCT
mkg-48486	120	7	methylation	methylation	NOUN
mkg-48486	120	8	at	at	ADP
mkg-48486	120	9	the	the	DET
mkg-48486	120	10	three	three	NUM
mkg-48486	120	11	methylation	methylation	NOUN
mkg-48486	120	12	points	point	NOUN
mkg-48486	120	13	of	of	ADP
mkg-48486	120	14	the	the	DET
mkg-48486	120	15	mthfr	mthfr	PROPN
mkg-48486	120	16	gene	gene	NOUN
mkg-48486	120	17	promoter	promoter	NOUN
mkg-48486	120	18	is	be	AUX
mkg-48486	120	19	not	not	PART
mkg-48486	120	20	a	a	DET
mkg-48486	120	21	factor	factor	NOUN
mkg-48486	120	22	causing	cause	VERB
mkg-48486	120	23	cl	cl	NOUN
mkg-48486	120	24	/	/	SYM
mkg-48486	120	25	p.	p.	NOUN
mkg-48486	120	26	other	other	ADJ
mkg-48486	120	27	assays	assay	NOUN
mkg-48486	120	28	can	can	AUX
mkg-48486	120	29	be	be	AUX
mkg-48486	120	30	designed	design	VERB
mkg-48486	120	31	for	for	SCONJ
mkg-48486	120	32	the	the	DET
mkg-48486	120	33	mthfr	mthfr	PROPN
mkg-48486	120	34	gene	gene	NOUN
mkg-48486	120	35	to	to	PART
mkg-48486	120	36	examine	examine	VERB
mkg-48486	120	37	different	different	ADJ
mkg-48486	120	38	methylation	methylation	NOUN
mkg-48486	120	39	point	point	NOUN
mkg-48486	120	40	locations	location	NOUN
mkg-48486	120	41	.	.	PUNCT
mkg-48486	121	1	in	in	ADP
mkg-48486	121	2	addition	addition	NOUN
mkg-48486	121	3	,	,	PUNCT
mkg-48486	121	4	methylation	methylation	NOUN
mkg-48486	121	5	point	point	NOUN
mkg-48486	121	6	locations	location	NOUN
mkg-48486	121	7	can	can	AUX
mkg-48486	121	8	be	be	AUX
mkg-48486	121	9	searched	search	VERB
mkg-48486	121	10	for	for	ADP
mkg-48486	121	11	in	in	ADP
mkg-48486	121	12	other	other	ADJ
mkg-48486	121	13	genes	gene	NOUN
mkg-48486	121	14	such	such	ADJ
mkg-48486	121	15	as	as	ADP
mkg-48486	121	16	the	the	DET
mkg-48486	121	17	dnmt	dnmt	NOUN
mkg-48486	121	18	gene	gene	NOUN
mkg-48486	121	19	because	because	SCONJ
mkg-48486	121	20	this	this	DET
mkg-48486	121	21	gene	gene	NOUN
mkg-48486	121	22	functions	function	NOUN
mkg-48486	121	23	as	as	ADP
mkg-48486	121	24	a	a	DET
mkg-48486	121	25	dna	dna	PROPN
mkg-48486	121	26	methylation	methylation	NOUN
mkg-48486	121	27	catalyzer	catalyzer	NOUN
mkg-48486	121	28	.	.	PUNCT
mkg-48486	122	1	references	reference	NOUN
mkg-48486	122	2	1	1	NUM
mkg-48486	122	3	.	.	PUNCT
mkg-48486	123	1	nugraha	nugraha	PROPN
mkg-48486	123	2	ap	ap	PROPN
mkg-48486	123	3	,	,	PUNCT
mkg-48486	123	4	yang	yang	PROPN
mkg-48486	123	5	h	h	PROPN
mkg-48486	123	6	,	,	PUNCT
mkg-48486	123	7	chen	chen	PROPN
mkg-48486	123	8	j	j	PROPN
mkg-48486	123	9	,	,	PUNCT
mkg-48486	123	10	yang	yang	PROPN
mkg-48486	123	11	k	k	PROPN
mkg-48486	123	12	,	,	PUNCT
mkg-48486	123	13	kraisintu	kraisintu	VERB
mkg-48486	123	14	p	p	X
mkg-48486	123	15	,	,	PUNCT
mkg-48486	123	16	zaww	zaww	PROPN
mkg-48486	123	17	k	k	PROPN
mkg-48486	123	18	,	,	PUNCT
mkg-48486	123	19	ma	ma	PROPN
mkg-48486	123	20	a	a	PROPN
mkg-48486	123	21	,	,	PUNCT
mkg-48486	123	22	wang	wang	PROPN
mkg-48486	123	23	r	r	PROPN
mkg-48486	123	24	,	,	PUNCT
mkg-48486	123	25	alhadi	alhadi	PROPN
mkg-48486	123	26	neam	neam	PROPN
mkg-48486	123	27	,	,	PUNCT
mkg-48486	123	28	vanegas	vanegas	PROPN
mkg-48486	123	29	sáenz	sáenz	PROPN
mkg-48486	123	30	jr	jr	PROPN
mkg-48486	123	31	,	,	PUNCT
mkg-48486	123	32	hong	hong	PROPN
mkg-48486	123	33	g.	g.	PROPN
mkg-48486	123	34	β	β	NOUN
mkg-48486	123	35	-	-	PUNCT
mkg-48486	123	36	tricalcium	tricalcium	NOUN
mkg-48486	123	37	phosphate	phosphate	NOUN
mkg-48486	123	38	as	as	ADP
mkg-48486	123	39	alveolar	alveolar	ADJ
mkg-48486	123	40	bone	bone	NOUN
mkg-48486	123	41	grafting	grafting	NOUN
mkg-48486	123	42	in	in	ADP
mkg-48486	123	43	cleft	cleft	ADJ
mkg-48486	123	44	lip	lip	NOUN
mkg-48486	123	45	/	/	SYM
mkg-48486	123	46	palate	palate	NOUN
mkg-48486	123	47	:	:	PUNCT
mkg-48486	123	48	a	a	DET
mkg-48486	123	49	systematic	systematic	ADJ
mkg-48486	123	50	review	review	NOUN
mkg-48486	123	51	.	.	PUNCT
mkg-48486	124	1	dent	dent	NOUN
mkg-48486	124	2	j.	j.	PROPN
mkg-48486	124	3	2023	2023	NUM
mkg-48486	124	4	;	;	PUNCT
mkg-48486	124	5	11(10	11(10	NUM
mkg-48486	124	6	):	):	PUNCT
mkg-48486	124	7	234	234	NUM
mkg-48486	124	8	.	.	NOUN
mkg-48486	125	1	2	2	NUM
mkg-48486	125	2	.	.	X
mkg-48486	125	3	lesmana	lesmana	PROPN
mkg-48486	125	4	s	s	PROPN
mkg-48486	125	5	,	,	PUNCT
mkg-48486	125	6	auerkari	auerkari	ADJ
mkg-48486	125	7	ei	ei	PROPN
mkg-48486	125	8	.	.	PROPN
mkg-48486	125	9	genes	gene	NOUN
mkg-48486	125	10	contributing	contribute	VERB
mkg-48486	125	11	in	in	ADP
mkg-48486	125	12	cleft	cleft	ADJ
mkg-48486	125	13	lip	lip	NOUN
mkg-48486	125	14	and	and	CCONJ
mkg-48486	125	15	cleft	cleft	NOUN
mkg-48486	125	16	palate	palate	NOUN
mkg-48486	125	17	:	:	PUNCT
mkg-48486	125	18	a	a	DET
mkg-48486	125	19	literature	literature	NOUN
mkg-48486	125	20	review	review	NOUN
mkg-48486	125	21	.	.	PUNCT
mkg-48486	126	1	j	j	PROPN
mkg-48486	126	2	int	int	PROPN
mkg-48486	126	3	dent	dent	PROPN
mkg-48486	126	4	med	med	ADJ
mkg-48486	126	5	res	re	NOUN
mkg-48486	126	6	.	.	PROPN
mkg-48486	126	7	2016	2016	NUM
mkg-48486	126	8	;	;	PUNCT
mkg-48486	126	9	9(special	9(special	ADJ
mkg-48486	126	10	issue	issue	NOUN
mkg-48486	126	11	):	):	PUNCT
mkg-48486	126	12	441–8	441–8	PROPN
mkg-48486	126	13	.	.	NOUN
mkg-48486	127	1	3	3	X
mkg-48486	127	2	.	.	X
mkg-48486	127	3	centre	centre	NOUN
mkg-48486	127	4	for	for	ADP
mkg-48486	127	5	disease	disease	NOUN
mkg-48486	127	6	control	control	NOUN
mkg-48486	127	7	and	and	CCONJ
mkg-48486	127	8	prevention	prevention	NOUN
mkg-48486	127	9	(	(	PUNCT
mkg-48486	127	10	cdc	cdc	PROPN
mkg-48486	127	11	)	)	PUNCT
mkg-48486	127	12	.	.	PUNCT
mkg-48486	128	1	facts	fact	NOUN
mkg-48486	128	2	about	about	ADP
mkg-48486	128	3	cleft	cleft	NOUN
mkg-48486	128	4	lip	lip	NOUN
mkg-48486	128	5	and	and	CCONJ
mkg-48486	128	6	cleft	cleft	NOUN
mkg-48486	128	7	palate	palate	NOUN
mkg-48486	128	8	.	.	PUNCT
mkg-48486	129	1	birth	birth	NOUN
mkg-48486	129	2	defects	defect	NOUN
mkg-48486	129	3	.	.	PUNCT
mkg-48486	130	1	2020	2020	NUM
mkg-48486	130	2	.	.	PUNCT
mkg-48486	131	1	available	available	ADJ
mkg-48486	131	2	from	from	ADP
mkg-48486	131	3	:	:	PUNCT
mkg-48486	131	4	https://www	https://www	PROPN
mkg-48486	131	5	.	.	PUNCT
mkg-48486	131	6	cdc.gov/ncbddd/birthdefects/cleftlip.html	cdc.gov/ncbddd/birthdefects/cleftlip.html	PROPN
mkg-48486	131	7	.	.	PUNCT
mkg-48486	132	1	accessed	access	VERB
mkg-48486	132	2	2022	2022	NUM
mkg-48486	132	3	aug	aug	PROPN
mkg-48486	132	4	22	22	NUM
mkg-48486	132	5	.	.	PUNCT
mkg-48486	133	1	4	4	X
mkg-48486	133	2	.	.	X
mkg-48486	133	3	ittiwut	ittiwut	NOUN
mkg-48486	133	4	r	r	NOUN
mkg-48486	133	5	,	,	PUNCT
mkg-48486	133	6	siriwan	siriwan	NOUN
mkg-48486	133	7	p	p	X
mkg-48486	133	8	,	,	PUNCT
mkg-48486	133	9	suphapeetiporn	suphapeetiporn	ADJ
mkg-48486	133	10	k	k	NOUN
mkg-48486	133	11	,	,	PUNCT
mkg-48486	133	12	shotelersuk	shotelersuk	NOUN
mkg-48486	133	13	v.	v.	ADP
mkg-48486	133	14	epidemiology	epidemiology	NOUN
mkg-48486	133	15	of	of	ADP
mkg-48486	133	16	cleft	cleft	NOUN
mkg-48486	133	17	lip	lip	NOUN
mkg-48486	133	18	with	with	ADP
mkg-48486	133	19	or	or	CCONJ
mkg-48486	133	20	without	without	ADP
mkg-48486	133	21	cleft	cleft	NOUN
mkg-48486	133	22	palate	palate	NOUN
mkg-48486	133	23	in	in	ADP
mkg-48486	133	24	thais	thais	PROPN
mkg-48486	133	25	.	.	PUNCT
mkg-48486	134	1	asian	asian	PROPN
mkg-48486	134	2	biomed	biome	VERB
mkg-48486	134	3	.	.	PUNCT
mkg-48486	135	1	2017	2017	NUM
mkg-48486	135	2	;	;	PUNCT
mkg-48486	135	3	10(4	10(4	NUM
mkg-48486	135	4	):	):	PUNCT
mkg-48486	135	5	335–8	335–8	NOUN
mkg-48486	135	6	.	.	NOUN
mkg-48486	135	7	5	5	NUM
mkg-48486	135	8	.	.	X
mkg-48486	135	9	priyono	priyono	PROPN
mkg-48486	135	10	gp	gp	PROPN
mkg-48486	135	11	,	,	PUNCT
mkg-48486	135	12	rafiyah	rafiyah	PROPN
mkg-48486	135	13	i	i	PRON
mkg-48486	135	14	,	,	PUNCT
mkg-48486	135	15	nurhidayah	nurhidayah	PROPN
mkg-48486	135	16	i.	i.	PROPN
mkg-48486	135	17	parents	parents	PROPN
mkg-48486	135	18	’	’	PART
mkg-48486	135	19	self	self	NOUN
mkg-48486	135	20	esteem	esteem	NOUN
mkg-48486	135	21	of	of	ADP
mkg-48486	135	22	children	child	NOUN
mkg-48486	135	23	with	with	ADP
mkg-48486	135	24	cleft	cleft	ADJ
mkg-48486	135	25	lip	lip	NOUN
mkg-48486	135	26	and	and	CCONJ
mkg-48486	135	27	palate	palate	VERB
mkg-48486	135	28	.	.	PUNCT
mkg-48486	136	1	j	j	PROPN
mkg-48486	136	2	nurs	nur	VERB
mkg-48486	136	3	care	care	VERB
mkg-48486	136	4	.	.	PUNCT
mkg-48486	137	1	2018	2018	NUM
mkg-48486	137	2	;	;	PUNCT
mkg-48486	137	3	1(2	1(2	NUM
mkg-48486	137	4	):	):	PUNCT
mkg-48486	137	5	164–71	164–71	NOUN
mkg-48486	137	6	.	.	PUNCT
mkg-48486	138	1	6	6	NUM
mkg-48486	138	2	.	.	X
mkg-48486	138	3	taslim	taslim	PROPN
mkg-48486	138	4	t	t	PROPN
mkg-48486	138	5	,	,	PUNCT
mkg-48486	138	6	joenoes	joenoes	PROPN
mkg-48486	138	7	h	h	PROPN
mkg-48486	138	8	,	,	PUNCT
mkg-48486	138	9	sulistyani	sulistyani	PROPN
mkg-48486	138	10	ld	ld	PROPN
mkg-48486	138	11	,	,	PUNCT
mkg-48486	138	12	latief	latief	NOUN
mkg-48486	138	13	bs	bs	NOUN
mkg-48486	138	14	,	,	PUNCT
mkg-48486	138	15	auerkari	auerkari	ADJ
mkg-48486	138	16	ei	ei	PROPN
mkg-48486	138	17	.	.	PROPN
mkg-48486	138	18	mthfr	mthfr	PROPN
mkg-48486	138	19	c677	c677	PROPN
mkg-48486	138	20	t	t	PROPN
mkg-48486	138	21	polymorphism	polymorphism	NOUN
mkg-48486	138	22	in	in	ADP
mkg-48486	138	23	indonesian	indonesian	ADJ
mkg-48486	138	24	patients	patient	NOUN
mkg-48486	138	25	with	with	ADP
mkg-48486	138	26	oral	oral	ADJ
mkg-48486	138	27	cleft	cleft	NOUN
mkg-48486	138	28	.	.	PUNCT
mkg-48486	139	1	j	j	PROPN
mkg-48486	139	2	int	int	PROPN
mkg-48486	139	3	dent	dent	PROPN
mkg-48486	139	4	med	med	ADJ
mkg-48486	139	5	res	re	NOUN
mkg-48486	139	6	.	.	PROPN
mkg-48486	139	7	2017	2017	NUM
mkg-48486	139	8	;	;	PUNCT
mkg-48486	139	9	10(special	10(special	NUM
mkg-48486	139	10	issue	issue	NOUN
mkg-48486	139	11	):	):	PUNCT
mkg-48486	139	12	723–8	723–8	X
mkg-48486	139	13	.	.	NOUN
mkg-48486	139	14	7	7	X
mkg-48486	139	15	.	.	X
mkg-48486	139	16	sosiawan	sosiawan	PROPN
mkg-48486	140	1	a	a	DET
mkg-48486	140	2	,	,	PUNCT
mkg-48486	140	3	kurniati	kurniati	PROPN
mkg-48486	140	4	m	m	PROPN
mkg-48486	140	5	,	,	PUNCT
mkg-48486	140	6	danudiningrat	danudiningrat	PROPN
mkg-48486	140	7	cp	cp	PROPN
mkg-48486	140	8	,	,	PUNCT
mkg-48486	140	9	wahjuningrum	wahjuningrum	PROPN
mkg-48486	140	10	da	da	PROPN
mkg-48486	140	11	,	,	PUNCT
mkg-48486	140	12	mulyawan	mulyawan	PROPN
mkg-48486	140	13	i.	i.	NOUN
mkg-48486	140	14	the	the	DET
mkg-48486	140	15	role	role	NOUN
mkg-48486	140	16	of	of	ADP
mkg-48486	140	17	family	family	NOUN
mkg-48486	140	18	history	history	NOUN
mkg-48486	140	19	as	as	ADP
mkg-48486	140	20	a	a	DET
mkg-48486	140	21	risk	risk	NOUN
mkg-48486	140	22	factor	factor	NOUN
mkg-48486	140	23	for	for	ADP
mkg-48486	140	24	nonsyndromic	nonsyndromic	ADJ
mkg-48486	140	25	cleft	cleft	NOUN
mkg-48486	140	26	lip	lip	NOUN
mkg-48486	140	27	and/or	and/or	CCONJ
mkg-48486	140	28	palate	palate	VERB
mkg-48486	140	29	with	with	ADP
mkg-48486	140	30	multifactorial	multifactorial	ADJ
mkg-48486	140	31	inheritance	inheritance	NOUN
mkg-48486	140	32	.	.	PUNCT
mkg-48486	141	1	dent	dent	NOUN
mkg-48486	141	2	j.	j.	PROPN
mkg-48486	141	3	2021	2021	NUM
mkg-48486	141	4	;	;	PUNCT
mkg-48486	141	5	54(2	54(2	NUM
mkg-48486	141	6	):	):	PUNCT
mkg-48486	141	7	108–12	108–12	NOUN
mkg-48486	141	8	.	.	NOUN
mkg-48486	141	9	8	8	NUM
mkg-48486	141	10	.	.	PUNCT
mkg-48486	141	11	fitrie	fitrie	PROPN
mkg-48486	141	12	rni	rni	PROPN
mkg-48486	141	13	,	,	PUNCT
mkg-48486	141	14	hidayat	hidayat	PROPN
mkg-48486	141	15	m	m	PROPN
mkg-48486	141	16	,	,	PUNCT
mkg-48486	141	17	dahliana	dahliana	PROPN
mkg-48486	141	18	l.	l.	PROPN
mkg-48486	141	19	incidence	incidence	NOUN
mkg-48486	141	20	of	of	ADP
mkg-48486	141	21	cleft	cleft	NOUN
mkg-48486	141	22	lip	lip	NOUN
mkg-48486	141	23	with	with	ADP
mkg-48486	141	24	or	or	CCONJ
mkg-48486	141	25	without	without	ADP
mkg-48486	141	26	cleft	cleft	NOUN
mkg-48486	141	27	palate	palate	NOUN
mkg-48486	141	28	at	at	ADP
mkg-48486	141	29	yayasan	yayasan	PROPN
mkg-48486	141	30	pembina	pembina	PROPN
mkg-48486	141	31	penderita	penderita	PROPN
mkg-48486	141	32	celah	celah	PROPN
mkg-48486	141	33	bibir	bibir	PROPN
mkg-48486	141	34	dan	dan	PROPN
mkg-48486	141	35	langit	langit	PROPN
mkg-48486	141	36	-	-	PUNCT
mkg-48486	141	37	langit	langit	NOUN
mkg-48486	141	38	(	(	PUNCT
mkg-48486	141	39	yppcbl	yppcbl	NOUN
mkg-48486	141	40	)	)	PUNCT
mkg-48486	141	41	in	in	ADP
mkg-48486	141	42	2016	2016	NUM
mkg-48486	141	43	-	-	SYM
mkg-48486	141	44	2019	2019	NUM
mkg-48486	141	45	.	.	PUNCT
mkg-48486	142	1	j	j	PROPN
mkg-48486	142	2	med	med	ADJ
mkg-48486	142	3	heal	heal	NOUN
mkg-48486	142	4	.	.	PUNCT
mkg-48486	143	1	2022	2022	NUM
mkg-48486	143	2	;	;	PUNCT
mkg-48486	143	3	4(1	4(1	NOUN
mkg-48486	143	4	):	):	PUNCT
mkg-48486	143	5	12	12	NUM
mkg-48486	143	6	.	.	NOUN
mkg-48486	144	1	9	9	NUM
mkg-48486	144	2	.	.	X
mkg-48486	144	3	arif	arif	PROPN
mkg-48486	144	4	harahap	harahap	PROPN
mkg-48486	144	5	w.	w.	PROPN
mkg-48486	144	6	role	role	NOUN
mkg-48486	144	7	of	of	ADP
mkg-48486	144	8	dna	dna	PROPN
mkg-48486	144	9	methylation	methylation	NOUN
mkg-48486	144	10	as	as	ADP
mkg-48486	144	11	a	a	DET
mkg-48486	144	12	diagnostic	diagnostic	ADJ
mkg-48486	144	13	biomarker	biomarker	NOUN
mkg-48486	144	14	of	of	ADP
mkg-48486	144	15	sporadic	sporadic	ADJ
mkg-48486	144	16	breast	breast	NOUN
mkg-48486	144	17	cancer	cancer	NOUN
mkg-48486	144	18	.	.	PUNCT
mkg-48486	145	1	j	j	PROPN
mkg-48486	145	2	med	med	PROPN
mkg-48486	145	3	sci	sci	PROPN
mkg-48486	145	4	(	(	PUNCT
mkg-48486	145	5	berkala	berkala	PROPN
mkg-48486	145	6	ilmu	ilmu	PROPN
mkg-48486	145	7	kedokteran	kedokteran	PROPN
mkg-48486	145	8	)	)	PUNCT
mkg-48486	145	9	.	.	PUNCT
mkg-48486	146	1	2016	2016	NUM
mkg-48486	146	2	;	;	PUNCT
mkg-48486	146	3	48(4	48(4	NUM
mkg-48486	146	4	):	):	PUNCT
mkg-48486	146	5	42–3	42–3	NUM
mkg-48486	146	6	.	.	NOUN
mkg-48486	146	7	10	10	NUM
mkg-48486	146	8	.	.	PUNCT
mkg-48486	146	9	ferrazzi	ferrazzi	PROPN
mkg-48486	146	10	e	e	PROPN
mkg-48486	146	11	,	,	PUNCT
mkg-48486	146	12	tiso	tiso	PROPN
mkg-48486	146	13	g	g	PROPN
mkg-48486	146	14	,	,	PUNCT
mkg-48486	146	15	di	di	PROPN
mkg-48486	146	16	martino	martino	PROPN
mkg-48486	146	17	d.	d.	PROPN
mkg-48486	146	18	folic	folic	PROPN
mkg-48486	146	19	acid	acid	PROPN
mkg-48486	146	20	versus	versus	ADP
mkg-48486	146	21	5methyl	5methyl	NUM
mkg-48486	146	22	tetrahydrofolate	tetrahydrofolate	ADJ
mkg-48486	146	23	supplementation	supplementation	NOUN
mkg-48486	146	24	in	in	ADP
mkg-48486	146	25	pregnancy	pregnancy	NOUN
mkg-48486	146	26	.	.	PUNCT
mkg-48486	147	1	eur	eur	PROPN
mkg-48486	147	2	j	j	PROPN
mkg-48486	147	3	obstet	obstet	PROPN
mkg-48486	147	4	gynecol	gynecol	PROPN
mkg-48486	147	5	reprod	reprod	PROPN
mkg-48486	147	6	biol	biol	PROPN
mkg-48486	147	7	.	.	PUNCT
mkg-48486	148	1	2020	2020	NUM
mkg-48486	148	2	;	;	PUNCT
mkg-48486	148	3	253	253	NUM
mkg-48486	149	1	:	:	PUNCT
mkg-48486	149	2	312–9	312–9	X
mkg-48486	149	3	.	.	PROPN
mkg-48486	149	4	11	11	NUM
mkg-48486	149	5	.	.	PUNCT
mkg-48486	150	1	coppedè	coppedè	PROPN
mkg-48486	150	2	,	,	PUNCT
mkg-48486	150	3	stoccoro	stoccoro	PROPN
mkg-48486	150	4	,	,	PUNCT
mkg-48486	150	5	tannorella	tannorella	PROPN
mkg-48486	150	6	,	,	PUNCT
mkg-48486	150	7	gallo	gallo	PROPN
mkg-48486	150	8	,	,	PUNCT
mkg-48486	150	9	nicolì	nicolì	PROPN
mkg-48486	150	10	,	,	PUNCT
mkg-48486	150	11	migliore	migliore	PROPN
mkg-48486	150	12	.	.	PROPN
mkg-48486	150	13	association	association	PROPN
mkg-48486	150	14	of	of	ADP
mkg-48486	150	15	polymorphisms	polymorphism	NOUN
mkg-48486	150	16	in	in	ADP
mkg-48486	150	17	genes	gene	NOUN
mkg-48486	150	18	involved	involve	VERB
mkg-48486	150	19	in	in	ADP
mkg-48486	150	20	one	one	NUM
mkg-48486	150	21	-	-	PUNCT
mkg-48486	150	22	carbon	carbon	NOUN
mkg-48486	150	23	metabolism	metabolism	NOUN
mkg-48486	150	24	with	with	ADP
mkg-48486	150	25	mthfr	mthfr	PROPN
mkg-48486	150	26	methylation	methylation	NOUN
mkg-48486	150	27	levels	level	NOUN
mkg-48486	150	28	.	.	PUNCT
mkg-48486	151	1	int	int	PROPN
mkg-48486	151	2	j	j	PROPN
mkg-48486	151	3	mol	mol	ADP
mkg-48486	151	4	sci	sci	PROPN
mkg-48486	151	5	.	.	PROPN
mkg-48486	151	6	2019	2019	NUM
mkg-48486	151	7	;	;	PUNCT
mkg-48486	151	8	20(15	20(15	NUM
mkg-48486	151	9	):	):	PUNCT
mkg-48486	151	10	3754	3754	NUM
mkg-48486	151	11	.	.	PUNCT
mkg-48486	152	1	12	12	NUM
mkg-48486	152	2	.	.	PUNCT
mkg-48486	152	3	fleckhaus	fleckhaus	PROPN
mkg-48486	152	4	j	j	PROPN
mkg-48486	152	5	,	,	PUNCT
mkg-48486	152	6	schneider	schneider	PROPN
mkg-48486	152	7	pm	pm	PROPN
mkg-48486	152	8	.	.	PUNCT
mkg-48486	153	1	novel	novel	PROPN
mkg-48486	153	2	multiplex	multiplex	PROPN
mkg-48486	153	3	strategy	strategy	NOUN
mkg-48486	153	4	for	for	ADP
mkg-48486	153	5	dna	dna	PROPN
mkg-48486	153	6	methylation	methylation	NOUN
mkg-48486	153	7	-	-	PUNCT
mkg-48486	153	8	based	base	VERB
mkg-48486	153	9	age	age	NOUN
mkg-48486	153	10	prediction	prediction	NOUN
mkg-48486	153	11	from	from	ADP
mkg-48486	153	12	small	small	ADJ
mkg-48486	153	13	amounts	amount	NOUN
mkg-48486	153	14	of	of	ADP
mkg-48486	153	15	dna	dna	PROPN
mkg-48486	153	16	via	via	ADP
mkg-48486	153	17	pyrosequencing	pyrosequence	VERB
mkg-48486	153	18	.	.	PUNCT
mkg-48486	154	1	forensic	forensic	ADJ
mkg-48486	154	2	sci	sci	PROPN
mkg-48486	154	3	int	int	PROPN
mkg-48486	154	4	genet	genet	NOUN
mkg-48486	154	5	.	.	PUNCT
mkg-48486	155	1	2020	2020	NUM
mkg-48486	155	2	;	;	PUNCT
mkg-48486	155	3	44	44	NUM
mkg-48486	155	4	:	:	SYM
mkg-48486	155	5	102189	102189	NUM
mkg-48486	155	6	.	.	PUNCT
mkg-48486	156	1	13	13	NUM
mkg-48486	156	2	.	.	PUNCT
mkg-48486	157	1	wan	wan	PROPN
mkg-48486	157	2	l	l	PROPN
mkg-48486	157	3	,	,	PUNCT
mkg-48486	157	4	li	li	PROPN
mkg-48486	157	5	y	y	PROPN
mkg-48486	157	6	,	,	PUNCT
mkg-48486	157	7	zhang	zhang	PROPN
mkg-48486	157	8	z	z	PROPN
mkg-48486	157	9	,	,	PUNCT
mkg-48486	157	10	sun	sun	PROPN
mkg-48486	157	11	z	z	PROPN
mkg-48486	157	12	,	,	PUNCT
mkg-48486	157	13	he	he	PRON
mkg-48486	157	14	y	y	PROPN
mkg-48486	157	15	,	,	PUNCT
mkg-48486	157	16	li	li	PROPN
mkg-48486	157	17	r.	r.	PROPN
mkg-48486	157	18	methylenetetrahydrofolate	methylenetetrahydrofolate	PROPN
mkg-48486	157	19	reductase	reductase	NOUN
mkg-48486	157	20	and	and	CCONJ
mkg-48486	157	21	psychiatric	psychiatric	ADJ
mkg-48486	157	22	diseases	disease	NOUN
mkg-48486	157	23	.	.	PUNCT
mkg-48486	158	1	transl	transl	PROPN
mkg-48486	158	2	psychiatry	psychiatry	NOUN
mkg-48486	158	3	.	.	PUNCT
mkg-48486	159	1	2018	2018	NUM
mkg-48486	159	2	;	;	PUNCT
mkg-48486	159	3	8(1	8(1	NOUN
mkg-48486	159	4	):	):	PUNCT
mkg-48486	159	5	242	242	NUM
mkg-48486	159	6	.	.	X
mkg-48486	160	1	14	14	NUM
mkg-48486	160	2	.	.	PUNCT
mkg-48486	161	1	dell’edera	dell’edera	NOUN
mkg-48486	161	2	d	d	PROPN
mkg-48486	161	3	,	,	PUNCT
mkg-48486	161	4	tinelli	tinelli	ADV
mkg-48486	161	5	a	a	PRON
mkg-48486	161	6	,	,	PUNCT
mkg-48486	161	7	milazzo	milazzo	PROPN
mkg-48486	161	8	gn	gn	PROPN
mkg-48486	161	9	,	,	PUNCT
mkg-48486	161	10	malvasi	malvasi	PROPN
mkg-48486	161	11	a	a	PROPN
mkg-48486	161	12	,	,	PUNCT
mkg-48486	161	13	domenico	domenico	PROPN
mkg-48486	161	14	c	c	NOUN
mkg-48486	161	15	,	,	PUNCT
mkg-48486	161	16	pacella	pacella	NOUN
mkg-48486	161	17	e	e	NOUN
mkg-48486	161	18	,	,	PUNCT
mkg-48486	161	19	pierluigi	pierluigi	PROPN
mkg-48486	161	20	c	c	PROPN
mkg-48486	161	21	,	,	PUNCT
mkg-48486	161	22	giuseppe	giuseppe	PROPN
mkg-48486	161	23	t	t	PROPN
mkg-48486	161	24	,	,	PUNCT
mkg-48486	161	25	marcello	marcello	PROPN
mkg-48486	161	26	g	g	PROPN
mkg-48486	161	27	,	,	PUNCT
mkg-48486	161	28	francesco	francesco	PROPN
mkg-48486	161	29	l	l	PROPN
mkg-48486	161	30	,	,	PUNCT
mkg-48486	161	31	epifania	epifania	PROPN
mkg-48486	161	32	aa	aa	PROPN
mkg-48486	161	33	.	.	PUNCT
mkg-48486	161	34	effect	effect	NOUN
mkg-48486	161	35	of	of	ADP
mkg-48486	161	36	multivitamins	multivitamin	NOUN
mkg-48486	161	37	on	on	ADP
mkg-48486	161	38	plasma	plasma	NOUN
mkg-48486	161	39	homocysteine	homocysteine	NOUN
mkg-48486	161	40	in	in	ADP
mkg-48486	161	41	patients	patient	NOUN
mkg-48486	161	42	with	with	ADP
mkg-48486	161	43	the	the	DET
mkg-48486	161	44	5,10	5,10	NUM
mkg-48486	161	45	methylenetetrahydrofolate	methylenetetrahydrofolate	ADJ
mkg-48486	161	46	reductase	reductase	NOUN
mkg-48486	161	47	c677	c677	PROPN
mkg-48486	161	48	t	t	PROPN
mkg-48486	161	49	homozygous	homozygous	ADJ
mkg-48486	161	50	state	state	NOUN
mkg-48486	161	51	.	.	PUNCT
mkg-48486	162	1	mol	mol	ADP
mkg-48486	162	2	med	med	PROPN
mkg-48486	162	3	rep	rep	PROPN
mkg-48486	162	4	.	.	PROPN
mkg-48486	162	5	2013	2013	NUM
mkg-48486	162	6	;	;	PUNCT
mkg-48486	162	7	8(2	8(2	NUM
mkg-48486	162	8	):	):	PUNCT
mkg-48486	162	9	609–12	609–12	NOUN
mkg-48486	162	10	.	.	PUNCT
mkg-48486	162	11	15	15	NUM
mkg-48486	162	12	.	.	X
mkg-48486	163	1	nasroen	nasroen	PROPN
mkg-48486	163	2	sl	sl	PROPN
mkg-48486	163	3	,	,	PUNCT
mkg-48486	163	4	maskoen	maskoen	NOUN
mkg-48486	163	5	am	be	AUX
mkg-48486	163	6	,	,	PUNCT
mkg-48486	163	7	soedjana	soedjana	PROPN
mkg-48486	163	8	h	h	PROPN
mkg-48486	163	9	,	,	PUNCT
mkg-48486	163	10	soeria	soeria	PROPN
mkg-48486	163	11	soemantri	soemantri	VERB
mkg-48486	163	12	es	es	NOUN
mkg-48486	163	13	,	,	PUNCT
mkg-48486	163	14	hilmanto	hilmanto	PROPN
mkg-48486	163	15	d.	d.	PROPN
mkg-48486	164	1	the	the	DET
mkg-48486	164	2	effects	effect	NOUN
mkg-48486	164	3	of	of	ADP
mkg-48486	164	4	irf6	irf6	ADJ
mkg-48486	164	5	rs2235373	rs2235373	NOUN
mkg-48486	164	6	polymorphism	polymorphism	NOUN
mkg-48486	164	7	on	on	ADP
mkg-48486	164	8	mrna	mrna	PROPN
mkg-48486	164	9	expression	expression	NOUN
mkg-48486	164	10	changes	change	NOUN
mkg-48486	164	11	in	in	ADP
mkg-48486	164	12	non	non	ADJ
mkg-48486	164	13	-	-	ADJ
mkg-48486	164	14	syndromic	syndromic	ADJ
mkg-48486	164	15	cleft	cleft	NOUN
mkg-48486	164	16	lip	lip	NOUN
mkg-48486	164	17	and	and	CCONJ
mkg-48486	164	18	palate	palate	VERB
mkg-48486	164	19	with	with	ADP
mkg-48486	164	20	various	various	ADJ
mkg-48486	164	21	phenotypes	phenotype	NOUN
mkg-48486	164	22	.	.	PUNCT
mkg-48486	165	1	padjadjaran	padjadjaran	PROPN
mkg-48486	165	2	j	j	PROPN
mkg-48486	165	3	dent	dent	PROPN
mkg-48486	165	4	.	.	PUNCT
mkg-48486	166	1	2018	2018	NUM
mkg-48486	166	2	;	;	PUNCT
mkg-48486	166	3	30(3	30(3	NUM
mkg-48486	166	4	):	):	PUNCT
mkg-48486	166	5	221–30	221–30	NUM
mkg-48486	166	6	.	.	PUNCT
mkg-48486	167	1	16	16	NUM
mkg-48486	167	2	.	.	PUNCT
mkg-48486	168	1	kedar	kedar	PROPN
mkg-48486	168	2	r	r	PROPN
mkg-48486	168	3	,	,	PUNCT
mkg-48486	168	4	chandel	chandel	PROPN
mkg-48486	168	5	d.	d.	PROPN
mkg-48486	168	6	mthfr	mthfr	PROPN
mkg-48486	168	7	gene	gene	NOUN
mkg-48486	168	8	polymorphism	polymorphism	NOUN
mkg-48486	168	9	and	and	CCONJ
mkg-48486	168	10	associated	associate	VERB
mkg-48486	168	11	nutritional	nutritional	ADJ
mkg-48486	168	12	deficiency	deficiency	NOUN
mkg-48486	168	13	in	in	ADP
mkg-48486	168	14	the	the	DET
mkg-48486	168	15	etiology	etiology	NOUN
mkg-48486	168	16	and	and	CCONJ
mkg-48486	168	17	pathogenesis	pathogenesis	NOUN
mkg-48486	168	18	of	of	ADP
mkg-48486	168	19	down	down	ADP
mkg-48486	168	20	syndrome	syndrome	NOUN
mkg-48486	168	21	.	.	PUNCT
mkg-48486	169	1	egypt	egypt	PROPN
mkg-48486	169	2	j	j	PROPN
mkg-48486	169	3	med	med	PROPN
mkg-48486	169	4	hum	hum	PROPN
mkg-48486	169	5	genet	genet	PROPN
mkg-48486	169	6	.	.	PUNCT
mkg-48486	170	1	2019	2019	NUM
mkg-48486	170	2	;	;	PUNCT
mkg-48486	171	1	20(1	20(1	NUM
mkg-48486	171	2	):	):	PUNCT
mkg-48486	171	3	12	12	NUM
mkg-48486	171	4	.	.	PUNCT
mkg-48486	171	5	17	17	NUM
mkg-48486	171	6	.	.	PUNCT
mkg-48486	172	1	huang	huang	PROPN
mkg-48486	172	2	w	w	PROPN
mkg-48486	172	3	-	-	PROPN
mkg-48486	172	4	j	j	PROPN
mkg-48486	172	5	,	,	PUNCT
mkg-48486	172	6	lu	lu	PROPN
mkg-48486	172	7	x	x	PROPN
mkg-48486	172	8	-	-	PUNCT
mkg-48486	172	9	l	l	NOUN
mkg-48486	172	10	,	,	PUNCT
mkg-48486	172	11	li	li	PROPN
mkg-48486	172	12	j	j	PROPN
mkg-48486	172	13	-	-	PUNCT
mkg-48486	172	14	t	t	PROPN
mkg-48486	172	15	,	,	PUNCT
mkg-48486	172	16	zhang	zhang	PROPN
mkg-48486	172	17	j	j	PROPN
mkg-48486	172	18	-	-	PUNCT
mkg-48486	172	19	m.	m.	NOUN
mkg-48486	172	20	effects	effect	NOUN
mkg-48486	172	21	of	of	ADP
mkg-48486	172	22	folic	folic	ADJ
mkg-48486	172	23	acid	acid	NOUN
mkg-48486	172	24	on	on	ADP
mkg-48486	172	25	oligozoospermia	oligozoospermia	NOUN
mkg-48486	172	26	with	with	ADP
mkg-48486	172	27	mthfr	mthfr	NOUN
mkg-48486	172	28	polymorphisms	polymorphism	NOUN
mkg-48486	172	29	in	in	ADP
mkg-48486	172	30	term	term	NOUN
mkg-48486	172	31	of	of	ADP
mkg-48486	172	32	seminal	seminal	ADJ
mkg-48486	172	33	parameters	parameter	NOUN
mkg-48486	172	34	,	,	PUNCT
mkg-48486	172	35	dna	dna	NOUN
mkg-48486	172	36	fragmentation	fragmentation	NOUN
mkg-48486	172	37	,	,	PUNCT
mkg-48486	172	38	and	and	CCONJ
mkg-48486	172	39	live	live	VERB
mkg-48486	172	40	birth	birth	NOUN
mkg-48486	172	41	rate	rate	NOUN
mkg-48486	172	42	:	:	PUNCT
mkg-48486	172	43	a	a	DET
mkg-48486	172	44	double	double	ADJ
mkg-48486	172	45	-	-	PUNCT
mkg-48486	172	46	blind	blind	ADJ
mkg-48486	172	47	,	,	PUNCT
mkg-48486	172	48	randomized	randomize	VERB
mkg-48486	172	49	,	,	PUNCT
mkg-48486	172	50	placebo	placebo	NOUN
mkg-48486	172	51	-	-	PUNCT
mkg-48486	172	52	controlled	control	VERB
mkg-48486	172	53	trial	trial	NOUN
mkg-48486	172	54	.	.	PUNCT
mkg-48486	173	1	andrology	andrology	PROPN
mkg-48486	173	2	.	.	PUNCT
mkg-48486	174	1	2020	2020	NUM
mkg-48486	174	2	;	;	PUNCT
mkg-48486	174	3	8(1	8(1	NOUN
mkg-48486	174	4	):	):	PUNCT
mkg-48486	174	5	110–6	110–6	NUM
mkg-48486	174	6	.	.	PROPN
mkg-48486	174	7	18	18	NUM
mkg-48486	174	8	.	.	PUNCT
mkg-48486	175	1	loscalzo	loscalzo	PROPN
mkg-48486	175	2	j	j	PROPN
mkg-48486	175	3	,	,	PUNCT
mkg-48486	175	4	handy	handy	PROPN
mkg-48486	175	5	de	de	X
mkg-48486	175	6	.	.	PUNCT
mkg-48486	175	7	epigenetic	epigenetic	ADJ
mkg-48486	175	8	modifications	modification	NOUN
mkg-48486	175	9	:	:	PUNCT
mkg-48486	175	10	basic	basic	ADJ
mkg-48486	175	11	mechanisms	mechanism	NOUN
mkg-48486	175	12	and	and	CCONJ
mkg-48486	175	13	role	role	NOUN
mkg-48486	175	14	in	in	ADP
mkg-48486	175	15	cardiovascular	cardiovascular	ADJ
mkg-48486	175	16	disease	disease	NOUN
mkg-48486	175	17	(	(	PUNCT
mkg-48486	175	18	2013	2013	NUM
mkg-48486	175	19	grover	grover	NOUN
mkg-48486	175	20	conference	conference	NOUN
mkg-48486	175	21	series	series	PROPN
mkg-48486	175	22	)	)	PUNCT
mkg-48486	175	23	.	.	PUNCT
mkg-48486	176	1	pulm	pulm	NOUN
mkg-48486	176	2	circ	circ	PROPN
mkg-48486	176	3	.	.	PUNCT
mkg-48486	177	1	2014	2014	NUM
mkg-48486	177	2	;	;	PUNCT
mkg-48486	177	3	4(2	4(2	NUM
mkg-48486	177	4	):	):	PUNCT
mkg-48486	178	1	169–74	169–74	NUM
mkg-48486	178	2	.	.	PROPN
mkg-48486	179	1	19	19	NUM
mkg-48486	179	2	.	.	PUNCT
mkg-48486	180	1	liu	liu	PROPN
mkg-48486	180	2	h	h	PROPN
mkg-48486	180	3	-	-	PUNCT
mkg-48486	180	4	y	y	PROPN
mkg-48486	180	5	,	,	PUNCT
mkg-48486	180	6	liu	liu	PROPN
mkg-48486	180	7	s	s	PROPN
mkg-48486	180	8	-	-	PROPN
mkg-48486	180	9	m	m	PROPN
mkg-48486	180	10	,	,	PUNCT
mkg-48486	180	11	zhang	zhang	PROPN
mkg-48486	180	12	y	y	PROPN
mkg-48486	180	13	-	-	PUNCT
mkg-48486	180	14	z.	z.	PROPN
mkg-48486	180	15	maternal	maternal	ADJ
mkg-48486	180	16	folic	folic	ADJ
mkg-48486	180	17	acid	acid	NOUN
mkg-48486	180	18	supplementation	supplementation	NOUN
mkg-48486	180	19	mediates	mediate	NOUN
mkg-48486	180	20	offspring	offspre	VERB
mkg-48486	180	21	health	health	NOUN
mkg-48486	180	22	via	via	ADP
mkg-48486	180	23	dna	dna	PROPN
mkg-48486	180	24	methylation	methylation	NOUN
mkg-48486	180	25	.	.	PUNCT
mkg-48486	181	1	reprod	reprod	PROPN
mkg-48486	181	2	sci	sci	PROPN
mkg-48486	181	3	.	.	PROPN
mkg-48486	181	4	2020	2020	NUM
mkg-48486	181	5	;	;	PUNCT
mkg-48486	181	6	27(4	27(4	NUM
mkg-48486	181	7	):	):	PUNCT
mkg-48486	181	8	963–76	963–76	NUM
mkg-48486	181	9	.	.	PUNCT
mkg-48486	182	1	20	20	NUM
mkg-48486	182	2	.	.	PUNCT
mkg-48486	183	1	santana	santana	PROPN
mkg-48486	183	2	bezerra	bezerra	PROPN
mkg-48486	183	3	h	h	PROPN
mkg-48486	183	4	,	,	PUNCT
mkg-48486	183	5	severo	severo	PROPN
mkg-48486	183	6	de	de	X
mkg-48486	183	7	assis	assis	PROPN
mkg-48486	183	8	c	c	PROPN
mkg-48486	183	9	,	,	PUNCT
mkg-48486	183	10	dos	do	NOUN
mkg-48486	183	11	santos	santos	PROPN
mkg-48486	183	12	nunes	nunes	PROPN
mkg-48486	183	13	mk	mk	PROPN
mkg-48486	183	14	,	,	PUNCT
mkg-48486	183	15	wanderley	wanderley	PROPN
mkg-48486	183	16	de	de	PROPN
mkg-48486	183	17	queiroga	queiroga	PROPN
mkg-48486	183	18	evangelista	evangelista	PROPN
mkg-48486	183	19	i	i	PROPN
mkg-48486	183	20	,	,	PUNCT
mkg-48486	183	21	modesto	modesto	PROPN
mkg-48486	183	22	filho	filho	PROPN
mkg-48486	183	23	j	j	PROPN
mkg-48486	183	24	,	,	PUNCT
mkg-48486	183	25	alves	alves	PROPN
mkg-48486	183	26	pegado	pegado	PROPN
mkg-48486	183	27	gomes	gomes	PROPN
mkg-48486	183	28	cn	cn	PROPN
mkg-48486	183	29	,	,	PUNCT
mkg-48486	183	30	ferreira	ferreira	PROPN
mkg-48486	183	31	do	do	AUX
mkg-48486	183	32	nascimento	nascimento	PROPN
mkg-48486	183	33	ra	ra	PROPN
mkg-48486	183	34	,	,	PUNCT
mkg-48486	183	35	pordeus	pordeus	PROPN
mkg-48486	183	36	luna	luna	PROPN
mkg-48486	183	37	rc	rc	PROPN
mkg-48486	183	38	,	,	PUNCT
mkg-48486	183	39	de	de	PROPN
mkg-48486	183	40	carvalho	carvalho	PROPN
mkg-48486	183	41	costa	costa	PROPN
mkg-48486	183	42	mj	mj	PROPN
mkg-48486	183	43	,	,	PUNCT
mkg-48486	183	44	de	de	PROPN
mkg-48486	183	45	oliveira	oliveira	PROPN
mkg-48486	183	46	nfp	nfp	PROPN
mkg-48486	183	47	,	,	PUNCT
mkg-48486	183	48	camati	camati	PROPN
mkg-48486	183	49	persuhn	persuhn	PROPN
mkg-48486	183	50	d.	d.	PROPN
mkg-48486	183	51	the	the	DET
mkg-48486	183	52	mthfr	mthfr	PROPN
mkg-48486	183	53	promoter	promoter	NOUN
mkg-48486	183	54	hypermethylation	hypermethylation	NOUN
mkg-48486	183	55	pattern	pattern	NOUN
mkg-48486	183	56	associated	associate	VERB
mkg-48486	183	57	with	with	ADP
mkg-48486	183	58	the	the	DET
mkg-48486	183	59	a1298c	a1298c	PROPN
mkg-48486	183	60	polymorphism	polymorphism	NOUN
mkg-48486	183	61	influences	influence	VERB
mkg-48486	183	62	lipid	lipid	NOUN
mkg-48486	183	63	parameters	parameter	NOUN
mkg-48486	183	64	and	and	CCONJ
mkg-48486	183	65	glycemic	glycemic	ADJ
mkg-48486	183	66	control	control	NOUN
mkg-48486	183	67	in	in	ADP
mkg-48486	183	68	diabetic	diabetic	ADJ
mkg-48486	183	69	patients	patient	NOUN
mkg-48486	183	70	.	.	PUNCT
mkg-48486	184	1	diabetol	diabetol	VERB
mkg-48486	184	2	metab	metab	ADJ
mkg-48486	184	3	syndr	syndr	NOUN
mkg-48486	184	4	.	.	PUNCT
mkg-48486	185	1	2019	2019	NUM
mkg-48486	185	2	;	;	PUNCT
mkg-48486	185	3	11(1	11(1	NUM
mkg-48486	185	4	):	):	PUNCT
mkg-48486	185	5	4	4	NUM
mkg-48486	185	6	.	.	NUM
mkg-48486	185	7	21	21	NUM
mkg-48486	185	8	.	.	PUNCT
mkg-48486	186	1	charoenvicha	charoenvicha	PROPN
mkg-48486	186	2	c	c	PROPN
mkg-48486	186	3	,	,	PUNCT
mkg-48486	186	4	sirimaharaj	sirimaharaj	PROPN
mkg-48486	186	5	w	w	PROPN
mkg-48486	186	6	,	,	PUNCT
mkg-48486	186	7	khwanngern	khwanngern	PROPN
mkg-48486	186	8	k	k	PROPN
mkg-48486	186	9	,	,	PUNCT
mkg-48486	186	10	chattipakorn	chattipakorn	ADJ
mkg-48486	186	11	n	n	CCONJ
mkg-48486	186	12	,	,	PUNCT
mkg-48486	186	13	chattipakorn	chattipakorn	ADJ
mkg-48486	186	14	s.	s.	PROPN
mkg-48486	186	15	alterations	alteration	NOUN
mkg-48486	186	16	in	in	ADP
mkg-48486	186	17	dna	dna	PROPN
mkg-48486	186	18	methylation	methylation	NOUN
mkg-48486	186	19	in	in	ADP
mkg-48486	186	20	orofacial	orofacial	ADJ
mkg-48486	186	21	clefts	cleft	NOUN
mkg-48486	186	22	.	.	PUNCT
mkg-48486	187	1	int	int	PROPN
mkg-48486	187	2	j	j	PROPN
mkg-48486	187	3	mol	mol	ADP
mkg-48486	187	4	sci	sci	PROPN
mkg-48486	187	5	.	.	PROPN
mkg-48486	187	6	2022	2022	NUM
mkg-48486	187	7	;	;	PUNCT
mkg-48486	187	8	23(21	23(21	NUM
mkg-48486	187	9	):	):	PUNCT
mkg-48486	187	10	12727	12727	NUM
mkg-48486	187	11	.	.	PUNCT
mkg-48486	188	1	copyright	copyright	NOUN
mkg-48486	188	2	©	©	ADP
mkg-48486	188	3	2024	2024	NUM
mkg-48486	188	4	dental	dental	ADJ
mkg-48486	188	5	journal	journal	NOUN
mkg-48486	188	6	(	(	PUNCT
mkg-48486	188	7	majalah	majalah	PROPN
mkg-48486	188	8	kedokteran	kedokteran	PROPN
mkg-48486	188	9	gigi	gigi	PROPN
mkg-48486	188	10	)	)	PUNCT
mkg-48486	189	1	p	p	X
mkg-48486	189	2	-	-	PUNCT
mkg-48486	189	3	issn	issn	NOUN
mkg-48486	189	4	:	:	PUNCT
mkg-48486	189	5	1978	1978	NUM
mkg-48486	189	6	-	-	SYM
mkg-48486	189	7	3728	3728	NUM
mkg-48486	189	8	;	;	PUNCT
mkg-48486	189	9	e	e	X
mkg-48486	189	10	-	-	PUNCT
mkg-48486	189	11	issn	issn	ADJ
mkg-48486	189	12	:	:	PUNCT
mkg-48486	189	13	2442	2442	NUM
mkg-48486	189	14	-	-	SYM
mkg-48486	189	15	9740	9740	NUM
mkg-48486	189	16	.	.	PUNCT
mkg-48486	190	1	accredited	accredit	VERB
mkg-48486	190	2	no	no	INTJ
mkg-48486	190	3	.	.	PROPN
mkg-48486	191	1	158	158	NUM
mkg-48486	191	2	/	/	SYM
mkg-48486	191	3	e	e	NOUN
mkg-48486	191	4	/	/	SYM
mkg-48486	191	5	kpt/2021	kpt/2021	NOUN
mkg-48486	191	6	.	.	PUNCT
mkg-48486	192	1	open	open	ADJ
mkg-48486	192	2	access	access	NOUN
mkg-48486	192	3	under	under	ADP
mkg-48486	192	4	cc	cc	NOUN
mkg-48486	192	5	-	-	PUNCT
mkg-48486	192	6	by	by	ADP
mkg-48486	192	7	-	-	PUNCT
mkg-48486	192	8	sa	sa	NOUN
mkg-48486	192	9	license	license	NOUN
mkg-48486	192	10	.	.	PUNCT
mkg-48486	193	1	available	available	ADJ
mkg-48486	193	2	at	at	ADP
mkg-48486	193	3	https://e-journal.unair.ac.id/mkg/index	https://e-journal.unair.ac.id/mkg/index	NOUN
mkg-48486	193	4	doi	doi	NOUN
mkg-48486	193	5	:	:	PUNCT
mkg-48486	193	6	10.20473	10.20473	NUM
mkg-48486	193	7	/	/	SYM
mkg-48486	193	8	j.djmkg.v57.i3.p184–188	j.djmkg.v57.i3.p184–188	NOUN
mkg-48486	193	9	https://www	https://www	PROPN
mkg-48486	193	10	https://e-journal.unair.ac.id/mkg/index	https://e-journal.unair.ac.id/mkg/index	NOUN
mkg-48486	193	11	https://doi.org/10.20473/j.djmkg.v57.i3.p184-188	https://doi.org/10.20473/j.djmkg.v57.i3.p184-188	VERB