id	sid	tid	token	lemma	pos
mkg-795	1	1	volume	volume	NOUN
mkg-795	1	2	46	46	NUM
mkg-795	1	3	number	number	NOUN
mkg-795	1	4	1	1	NUM
mkg-795	1	5	march	march	NOUN
mkg-795	1	6	2013	2013	NUM
mkg-795	1	7	antitumor	antitumor	PROPN
mkg-795	1	8	activity	activity	NOUN
mkg-795	1	9	of	of	ADP
mkg-795	1	10	antisense	antisense	NOUN
mkg-795	1	11	oligonucleotide	oligonucleotide	VERB
mkg-795	1	12	p	p	PROPN
mkg-795	1	13	�	�	PROPN
mkg-795	1	14	�	�	PROPN
mkg-795	1	15	skp	skp	PROPN
mkg-795	1	16	�	�	PROPN
mkg-795	1	17	in	in	ADP
mkg-795	1	18	soft	soft	ADJ
mkg-795	1	19	palate	palate	ADJ
mkg-795	1	20	carcinoma	carcinoma	NOUN
mkg-795	1	21	cell	cell	NOUN
mkg-795	1	22	squamous	squamous	ADJ
mkg-795	1	23	in	in	ADP
mkg-795	1	24	vitro	vitro	X
mkg-795	1	25	supriatno,1	supriatno,1	NOUN
mkg-795	1	26	sartari	sartari	X
mkg-795	1	27	entin	entin	PROPN
mkg-795	1	28	yuletnawati1	yuletnawati1	PROPN
mkg-795	1	29	and	and	CCONJ
mkg-795	1	30	iwa	iwa	NOUN
mkg-795	1	31	sutardjo	sutardjo	PROPN
mkg-795	1	32	rus	rus	NOUN
mkg-795	1	33	sudarso2	sudarso2	PROPN
mkg-795	1	34	1department	1department	NUM
mkg-795	1	35	of	of	ADP
mkg-795	1	36	oral	oral	ADJ
mkg-795	1	37	medicine	medicine	NOUN
mkg-795	1	38	2department	2department	NUM
mkg-795	1	39	of	of	ADP
mkg-795	1	40	pediatric	pediatric	ADJ
mkg-795	1	41	dentistry	dentistry	NOUN
mkg-795	1	42	faculty	faculty	NOUN
mkg-795	1	43	of	of	ADP
mkg-795	1	44	dentistry	dentistry	NOUN
mkg-795	1	45	,	,	PUNCT
mkg-795	2	1	universitas	universita	NOUN
mkg-795	2	2	gadjah	gadjah	PROPN
mkg-795	2	3	mada	mada	PROPN
mkg-795	2	4	yogyakarta	yogyakarta	PROPN
mkg-795	3	1	indonesia	indonesia	PROPN
mkg-795	3	2	abstract	abstract	PROPN
mkg-795	3	3	background	background	NOUN
mkg-795	3	4	:	:	PUNCT
mkg-795	4	1	human	human	ADJ
mkg-795	4	2	soft	soft	ADJ
mkg-795	4	3	palate	palate	ADJ
mkg-795	4	4	cancers	cancer	NOUN
mkg-795	4	5	are	be	AUX
mkg-795	4	6	characterized	characterize	VERB
mkg-795	4	7	by	by	ADP
mkg-795	4	8	a	a	DET
mkg-795	4	9	high	high	ADJ
mkg-795	4	10	degree	degree	NOUN
mkg-795	4	11	of	of	ADP
mkg-795	4	12	local	local	ADJ
mkg-795	4	13	invasion	invasion	NOUN
mkg-795	4	14	and	and	CCONJ
mkg-795	4	15	metastasis	metastasis	NOUN
mkg-795	4	16	to	to	ADP
mkg-795	4	17	the	the	DET
mkg-795	4	18	regional	regional	ADJ
mkg-795	4	19	lymph	lymph	NOUN
mkg-795	4	20	nodes	node	NOUN
mkg-795	4	21	.	.	PUNCT
mkg-795	5	1	treatment	treatment	NOUN
mkg-795	5	2	options	option	NOUN
mkg-795	5	3	for	for	ADP
mkg-795	5	4	this	this	DET
mkg-795	5	5	cancer	cancer	NOUN
mkg-795	5	6	are	be	AUX
mkg-795	5	7	limited	limited	ADJ
mkg-795	5	8	.	.	PUNCT
mkg-795	6	1	however	however	ADV
mkg-795	6	2	,	,	PUNCT
mkg-795	6	3	a	a	DET
mkg-795	6	4	new	new	ADJ
mkg-795	6	5	strategy	strategy	NOUN
mkg-795	6	6	for	for	ADP
mkg-795	6	7	refractory	refractory	NOUN
mkg-795	6	8	cancer	cancer	NOUN
mkg-795	6	9	,	,	PUNCT
mkg-795	6	10	gene	gene	NOUN
mkg-795	6	11	therapy	therapy	NOUN
mkg-795	6	12	is	be	AUX
mkg-795	6	13	watched	watch	VERB
mkg-795	6	14	with	with	ADP
mkg-795	6	15	keen	keen	ADJ
mkg-795	6	16	interest	interest	NOUN
mkg-795	6	17	.	.	PUNCT
mkg-795	7	1	p45skp2	p45skp2	ADJ
mkg-795	7	2	gene	gene	NOUN
mkg-795	7	3	as	as	ADP
mkg-795	7	4	a	a	DET
mkg-795	7	5	tumor	tumor	NOUN
mkg-795	7	6	promoter	promoter	NOUN
mkg-795	7	7	gene	gene	NOUN
mkg-795	7	8	is	be	AUX
mkg-795	7	9	one	one	NUM
mkg-795	7	10	of	of	ADP
mkg-795	7	11	target	target	NOUN
mkg-795	7	12	of	of	ADP
mkg-795	7	13	the	the	DET
mkg-795	7	14	oral	oral	ADJ
mkg-795	7	15	cancer	cancer	NOUN
mkg-795	7	16	therapy	therapy	NOUN
mkg-795	7	17	.	.	PUNCT
mkg-795	8	1	to	to	PART
mkg-795	8	2	inhibit	inhibit	VERB
mkg-795	8	3	the	the	DET
mkg-795	8	4	activity	activity	NOUN
mkg-795	8	5	of	of	ADP
mkg-795	8	6	p45skp2	p45skp2	VERB
mkg-795	8	7	gene	gene	NOUN
mkg-795	8	8	is	be	AUX
mkg-795	8	9	carried	carry	VERB
mkg-795	8	10	-	-	PUNCT
mkg-795	8	11	out	out	ADP
mkg-795	8	12	the	the	DET
mkg-795	8	13	genetic	genetic	ADJ
mkg-795	8	14	engineering	engineering	NOUN
mkg-795	8	15	via	via	ADP
mkg-795	8	16	antisense	antisense	NOUN
mkg-795	8	17	technique	technique	NOUN
mkg-795	8	18	.	.	PUNCT
mkg-795	9	1	purpose	purpose	NOUN
mkg-795	9	2	:	:	PUNCT
mkg-795	9	3	to	to	PART
mkg-795	9	4	examine	examine	VERB
mkg-795	9	5	the	the	DET
mkg-795	9	6	antitumor	antitumor	PROPN
mkg-795	9	7	activity	activity	NOUN
mkg-795	9	8	of	of	ADP
mkg-795	9	9	p45skp2	p45skp2	ADJ
mkg-795	9	10	antisense	antisense	NOUN
mkg-795	9	11	(	(	PUNCT
mkg-795	9	12	p45skp2	p45skp2	VERB
mkg-795	9	13	as	as	ADP
mkg-795	9	14	)	)	PUNCT
mkg-795	9	15	gene	gene	NOUN
mkg-795	9	16	therapy	therapy	NOUN
mkg-795	9	17	in	in	ADP
mkg-795	9	18	human	human	ADJ
mkg-795	9	19	soft	soft	ADJ
mkg-795	9	20	palate	palate	NOUN
mkg-795	9	21	[	[	PUNCT
mkg-795	9	22	hamakawa	hamakawa	NOUN
mkg-795	9	23	-	-	PUNCT
mkg-795	9	24	inoue	inoue	NOUN
mkg-795	9	25	(	(	PUNCT
mkg-795	9	26	hi	hi	INTJ
mkg-795	9	27	)	)	PUNCT
mkg-795	9	28	]	]	PUNCT
mkg-795	9	29	cancer	cancer	NOUN
mkg-795	9	30	cells	cell	NOUN
mkg-795	9	31	.	.	PUNCT
mkg-795	10	1	methods	method	NOUN
mkg-795	10	2	:	:	PUNCT
mkg-795	10	3	pure	pure	ADJ
mkg-795	10	4	laboratory	laboratory	NOUN
mkg-795	10	5	experimental	experimental	ADJ
mkg-795	10	6	study	study	NOUN
mkg-795	10	7	with	with	ADP
mkg-795	10	8	post	post	NOUN
mkg-795	10	9	test	test	NOUN
mkg-795	10	10	only	only	ADV
mkg-795	10	11	control	control	NOUN
mkg-795	10	12	group	group	NOUN
mkg-795	10	13	design	design	NOUN
mkg-795	10	14	was	be	AUX
mkg-795	10	15	conducted	conduct	VERB
mkg-795	10	16	as	as	ADP
mkg-795	10	17	a	a	DET
mkg-795	10	18	research	research	NOUN
mkg-795	10	19	design	design	NOUN
mkg-795	10	20	.	.	PUNCT
mkg-795	11	1	to	to	PART
mkg-795	11	2	investigate	investigate	VERB
mkg-795	11	3	the	the	DET
mkg-795	11	4	apoptosis	apoptosis	NOUN
mkg-795	11	5	induction	induction	NOUN
mkg-795	11	6	of	of	ADP
mkg-795	11	7	p45skp2	p45skp2	VERB
mkg-795	11	8	astransfected	astransfecte	VERB
mkg-795	11	9	cell	cell	NOUN
mkg-795	11	10	was	be	AUX
mkg-795	11	11	evaluated	evaluate	VERB
mkg-795	11	12	by	by	ADP
mkg-795	11	13	colorimetric	colorimetric	ADJ
mkg-795	11	14	caspase-3	caspase-3	NUM
mkg-795	11	15	assay	assay	NOUN
mkg-795	11	16	and	and	CCONJ
mkg-795	11	17	flow	flow	VERB
mkg-795	11	18	cytometry	cytometry	NOUN
mkg-795	11	19	.	.	PUNCT
mkg-795	12	1	furthermore	furthermore	ADV
mkg-795	12	2	,	,	PUNCT
mkg-795	12	3	to	to	PART
mkg-795	12	4	detect	detect	VERB
mkg-795	12	5	the	the	DET
mkg-795	12	6	suppression	suppression	NOUN
mkg-795	12	7	of	of	ADP
mkg-795	12	8	in	in	ADP
mkg-795	12	9	vitro	vitro	X
mkg-795	12	10	hi	hi	ADJ
mkg-795	12	11	cell	cell	NOUN
mkg-795	12	12	invasion	invasion	NOUN
mkg-795	12	13	and	and	CCONJ
mkg-795	12	14	cell	cell	NOUN
mkg-795	12	15	growth	growth	NOUN
mkg-795	12	16	of	of	ADP
mkg-795	12	17	p45skp2	p45skp2	NOUN
mkg-795	12	18	as	as	ADP
mkg-795	12	19	-	-	PUNCT
mkg-795	12	20	treatment	treatment	NOUN
mkg-795	12	21	cell	cell	NOUN
mkg-795	12	22	was	be	AUX
mkg-795	12	23	examined	examine	VERB
mkg-795	12	24	by	by	ADP
mkg-795	12	25	boyden	boyden	PROPN
mkg-795	12	26	chamber	chamber	PROPN
mkg-795	12	27	kit	kit	NOUN
mkg-795	12	28	and	and	CCONJ
mkg-795	12	29	mtt	mtt	NOUN
mkg-795	12	30	assay	assay	VERB
mkg-795	12	31	,	,	PUNCT
mkg-795	12	32	respectively	respectively	ADV
mkg-795	12	33	.	.	PUNCT
mkg-795	13	1	results	result	NOUN
mkg-795	13	2	:	:	PUNCT
mkg-795	13	3	the	the	DET
mkg-795	13	4	cell	cell	NOUN
mkg-795	13	5	number	number	NOUN
mkg-795	13	6	of	of	ADP
mkg-795	13	7	p45skp2	p45skp2	NOUN
mkg-795	13	8	as	as	ADP
mkg-795	13	9	-	-	PUNCT
mkg-795	13	10	treated	treat	VERB
mkg-795	13	11	hi	hi	NOUN
mkg-795	13	12	cell	cell	NOUN
mkg-795	13	13	was	be	AUX
mkg-795	13	14	significant	significant	ADJ
mkg-795	13	15	decreased	decrease	VERB
mkg-795	13	16	when	when	SCONJ
mkg-795	13	17	compared	compare	VERB
mkg-795	13	18	with	with	ADP
mkg-795	13	19	that	that	PRON
mkg-795	13	20	of	of	ADP
mkg-795	13	21	p45skp2	p45skp2	ADJ
mkg-795	13	22	sense	sense	NOUN
mkg-795	13	23	(	(	PUNCT
mkg-795	13	24	p45skp2	p45skp2	NOUN
mkg-795	13	25	s	s	NOUN
mkg-795	13	26	)	)	PUNCT
mkg-795	13	27	cells	cell	NOUN
mkg-795	13	28	(	(	PUNCT
mkg-795	13	29	p<0.05	p<0.05	NOUN
mkg-795	13	30	)	)	PUNCT
mkg-795	13	31	.	.	PUNCT
mkg-795	14	1	p45skp2	p45skp2	VERB
mkg-795	14	2	as	as	ADP
mkg-795	14	3	-	-	PUNCT
mkg-795	14	4	treated	treat	VERB
mkg-795	14	5	cell	cell	NOUN
mkg-795	14	6	induced	induce	VERB
mkg-795	14	7	apoptosis	apoptosis	NOUN
mkg-795	14	8	characterized	characterize	VERB
mkg-795	14	9	by	by	ADP
mkg-795	14	10	an	an	DET
mkg-795	14	11	increase	increase	NOUN
mkg-795	14	12	in	in	ADP
mkg-795	14	13	the	the	DET
mkg-795	14	14	early	early	ADJ
mkg-795	14	15	and	and	CCONJ
mkg-795	14	16	late	late	ADJ
mkg-795	14	17	apoptosis	apoptosis	NOUN
mkg-795	14	18	,	,	PUNCT
mkg-795	14	19	and	and	CCONJ
mkg-795	14	20	activation	activation	NOUN
mkg-795	14	21	of	of	ADP
mkg-795	14	22	caspase-3	caspase-3	PROPN
mkg-795	14	23	(	(	PUNCT
mkg-795	14	24	p<0.05	p<0.05	PROPN
mkg-795	14	25	)	)	PUNCT
mkg-795	14	26	.	.	PUNCT
mkg-795	15	1	therefore	therefore	ADV
mkg-795	15	2	,	,	PUNCT
mkg-795	15	3	suppression	suppression	NOUN
mkg-795	15	4	of	of	ADP
mkg-795	15	5	hi	hi	ADJ
mkg-795	15	6	cell	cell	NOUN
mkg-795	15	7	invasion	invasion	NOUN
mkg-795	15	8	and	and	CCONJ
mkg-795	15	9	cell	cell	NOUN
mkg-795	15	10	growth	growth	NOUN
mkg-795	15	11	were	be	AUX
mkg-795	15	12	markedly	markedly	ADV
mkg-795	15	13	increased	increase	VERB
mkg-795	15	14	by	by	ADP
mkg-795	15	15	p45skp2	p45skp2	NOUN
mkg-795	15	16	as	as	ADP
mkg-795	15	17	treatment	treatment	NOUN
mkg-795	15	18	(	(	PUNCT
mkg-795	15	19	p<0.05	p<0.05	NOUN
mkg-795	15	20	)	)	PUNCT
mkg-795	15	21	.	.	PUNCT
mkg-795	16	1	conclusion	conclusion	NOUN
mkg-795	16	2	:	:	PUNCT
mkg-795	16	3	antisense	antisense	NOUN
mkg-795	16	4	oligonucleotide	oligonucleotide	NOUN
mkg-795	16	5	p45skp2	p45skp2	NOUN
mkg-795	16	6	has	have	VERB
mkg-795	16	7	a	a	DET
mkg-795	16	8	high	high	ADJ
mkg-795	16	9	antitumor	antitumor	NOUN
mkg-795	16	10	activity	activity	NOUN
mkg-795	16	11	in	in	ADP
mkg-795	16	12	human	human	ADJ
mkg-795	16	13	soft	soft	ADJ
mkg-795	16	14	palate	palate	NOUN
mkg-795	16	15	cancer	cancer	NOUN
mkg-795	16	16	cell	cell	NOUN
mkg-795	16	17	,	,	PUNCT
mkg-795	16	18	targeting	target	VERB
mkg-795	16	19	this	this	DET
mkg-795	16	20	molecule	molecule	NOUN
mkg-795	16	21	could	could	AUX
mkg-795	16	22	represent	represent	VERB
mkg-795	16	23	a	a	DET
mkg-795	16	24	promising	promising	ADJ
mkg-795	16	25	new	new	ADJ
mkg-795	16	26	therapeutics	therapeutic	NOUN
mkg-795	16	27	approach	approach	NOUN
mkg-795	16	28	for	for	ADP
mkg-795	16	29	this	this	DET
mkg-795	16	30	type	type	NOUN
mkg-795	16	31	of	of	ADP
mkg-795	16	32	cancer	cancer	NOUN
mkg-795	16	33	.	.	PUNCT
mkg-795	17	1	key	key	ADJ
mkg-795	17	2	words	word	NOUN
mkg-795	17	3	:	:	PUNCT
mkg-795	17	4	antisense	antisense	NOUN
mkg-795	17	5	p45skp2	p45skp2	ADJ
mkg-795	17	6	gene	gene	NOUN
mkg-795	17	7	,	,	PUNCT
mkg-795	17	8	apoptosis	apoptosis	NOUN
mkg-795	17	9	,	,	PUNCT
mkg-795	17	10	invasion	invasion	NOUN
mkg-795	17	11	,	,	PUNCT
mkg-795	17	12	soft	soft	ADJ
mkg-795	17	13	palate	palate	ADJ
mkg-795	17	14	cancer	cancer	NOUN
mkg-795	17	15	cell	cell	NOUN
mkg-795	17	16	abstrak	abstrak	PROPN
mkg-795	17	17	latar	latar	PROPN
mkg-795	17	18	belakang	belakang	PROPN
mkg-795	17	19	:	:	PUNCT
mkg-795	17	20	kanker	kanker	NOUN
mkg-795	17	21	palatum	palatum	PROPN
mkg-795	17	22	lunak	lunak	PROPN
mkg-795	17	23	mempunyai	mempunyai	PROPN
mkg-795	17	24	karakteristik	karakteristik	PROPN
mkg-795	17	25	invasi	invasi	PROPN
mkg-795	18	1	dan	dan	PROPN
mkg-795	18	2	metastasis	metastasis	NOUN
mkg-795	18	3	ke	ke	NOUN
mkg-795	18	4	limfonodi	limfonodi	VERB
mkg-795	18	5	regional	regional	PROPN
mkg-795	18	6	yang	yang	PROPN
mkg-795	18	7	tinggi	tinggi	PROPN
mkg-795	18	8	.	.	PUNCT
mkg-795	19	1	pilihan	pilihan	PROPN
mkg-795	19	2	perawatan	perawatan	PROPN
mkg-795	19	3	kanker	kanker	PROPN
mkg-795	19	4	tersebut	tersebut	PROPN
mkg-795	19	5	masih	masih	PROPN
mkg-795	19	6	sangat	sangat	PROPN
mkg-795	19	7	terbatas	terbatas	PROPN
mkg-795	19	8	.	.	PUNCT
mkg-795	20	1	walaupun	walaupun	PROPN
mkg-795	20	2	demikian	demikian	PROPN
mkg-795	20	3	,	,	PUNCT
mkg-795	20	4	strategi	strategi	PROPN
mkg-795	20	5	baru	baru	PROPN
mkg-795	20	6	untuk	untuk	PROPN
mkg-795	20	7	penanganan	penanganan	PROPN
mkg-795	20	8	kanker	kanker	PROPN
mkg-795	20	9	yaitu	yaitu	PROPN
mkg-795	20	10	terapi	terapi	PROPN
mkg-795	20	11	gen	gen	PROPN
mkg-795	20	12	menjadi	menjadi	PROPN
mkg-795	20	13	pilihan	pilihan	PROPN
mkg-795	20	14	utama	utama	PROPN
mkg-795	20	15	.	.	PUNCT
mkg-795	21	1	gen	gen	PROPN
mkg-795	21	2	p45skp2	p45skp2	ADJ
mkg-795	21	3	sebagai	sebagai	PROPN
mkg-795	21	4	gen	gen	PROPN
mkg-795	21	5	pemacu	pemacu	PROPN
mkg-795	21	6	tumor	tumor	PROPN
mkg-795	21	7	merupakan	merupakan	PROPN
mkg-795	21	8	salah	salah	PROPN
mkg-795	21	9	satu	satu	PROPN
mkg-795	21	10	target	target	PROPN
mkg-795	21	11	terapi	terapi	PROPN
mkg-795	21	12	kanker	kanker	PROPN
mkg-795	21	13	oral	oral	PROPN
mkg-795	21	14	.	.	PUNCT
mkg-795	22	1	untuk	untuk	PROPN
mkg-795	22	2	menghambat	menghambat	PROPN
mkg-795	22	3	aktivitas	aktivitas	PROPN
mkg-795	22	4	gen	gen	PROPN
mkg-795	22	5	p45skp2	p45skp2	VERB
mkg-795	22	6	tersebut	tersebut	PROPN
mkg-795	22	7	dilakukan	dilakukan	PROPN
mkg-795	22	8	rekayasa	rekayasa	PROPN
mkg-795	22	9	genetik	genetik	PROPN
mkg-795	22	10	melalui	melalui	PROPN
mkg-795	22	11	teknik	teknik	NOUN
mkg-795	22	12	antisense	antisense	NOUN
mkg-795	22	13	.	.	PUNCT
mkg-795	23	1	tujuan	tujuan	PROPN
mkg-795	23	2	:	:	PUNCT
mkg-795	23	3	menguji	menguji	PROPN
mkg-795	23	4	aktivitas	aktivita	VERB
mkg-795	23	5	antitumor	antitumor	PROPN
mkg-795	23	6	gen	gen	PROPN
mkg-795	23	7	p45skp2	p45skp2	ADJ
mkg-795	23	8	antisense	antisense	NOUN
mkg-795	23	9	(	(	PUNCT
mkg-795	23	10	p45skp2	p45skp2	VERB
mkg-795	23	11	as	as	ADP
mkg-795	23	12	)	)	PUNCT
mkg-795	23	13	terhadap	terhadap	PROPN
mkg-795	23	14	sel	sel	PROPN
mkg-795	23	15	kanker	kanker	PROPN
mkg-795	23	16	palatum	palatum	NOUN
mkg-795	23	17	lunak	lunak	NOUN
mkg-795	23	18	(	(	PUNCT
mkg-795	23	19	sel	sel	PROPN
mkg-795	23	20	hi	hi	ADJ
mkg-795	23	21	)	)	PUNCT
mkg-795	23	22	.	.	PUNCT
mkg-795	24	1	metode	metode	PROPN
mkg-795	24	2	:	:	PUNCT
mkg-795	24	3	jenis	jenis	PROPN
mkg-795	24	4	penelitian	penelitian	PROPN
mkg-795	24	5	yang	yang	PROPN
mkg-795	24	6	digunakan	digunakan	PROPN
mkg-795	24	7	adalah	adalah	PROPN
mkg-795	24	8	eksperimen	eksperimen	PROPN
mkg-795	24	9	laboratorik	laboratorik	PROPN
mkg-795	24	10	murni	murni	PROPN
mkg-795	24	11	dengan	dengan	PROPN
mkg-795	24	12	rancangan	rancangan	PROPN
mkg-795	24	13	posttest	postt	ADJ
mkg-795	24	14	only	only	ADV
mkg-795	24	15	control	control	NOUN
mkg-795	24	16	group	group	NOUN
mkg-795	24	17	design	design	NOUN
mkg-795	24	18	.	.	PUNCT
mkg-795	25	1	induksi	induksi	NOUN
mkg-795	25	2	apoptosis	apoptosis	NOUN
mkg-795	25	3	sel	sel	PROPN
mkg-795	25	4	yang	yang	PROPN
mkg-795	25	5	ditransfeksi	ditransfeksi	PROPN
mkg-795	25	6	p45skp2	p45skp2	NOUN
mkg-795	25	7	as	as	ADP
mkg-795	25	8	dievaluasi	dievaluasi	PROPN
mkg-795	25	9	menggunakan	menggunakan	PROPN
mkg-795	25	10	uji	uji	PROPN
mkg-795	25	11	caspase-3	caspase-3	NUM
mkg-795	25	12	kolorimetrik	kolorimetrik	PROPN
mkg-795	25	13	dan	dan	PROPN
mkg-795	25	14	flow	flow	PROPN
mkg-795	25	15	cytometry	cytometry	PROPN
mkg-795	25	16	.	.	PUNCT
mkg-795	26	1	untuk	untuk	PROPN
mkg-795	26	2	mendeteksi	mendeteksi	PROPN
mkg-795	26	3	hambatan	hambatan	PROPN
mkg-795	26	4	invasi	invasi	PROPN
mkg-795	26	5	dan	dan	PROPN
mkg-795	26	6	pertumbuhan	pertumbuhan	PROPN
mkg-795	26	7	sel	sel	PROPN
mkg-795	27	1	hi	hi	INTJ
mkg-795	27	2	yang	yang	PROPN
mkg-795	27	3	ditransfeksi	ditransfeksi	PROPN
mkg-795	27	4	p45skp2	p45skp2	NOUN
mkg-795	27	5	as	as	ADP
mkg-795	27	6	dilakukan	dilakukan	PROPN
mkg-795	27	7	uji	uji	PROPN
mkg-795	27	8	boyden	boyden	PROPN
mkg-795	27	9	chamber	chamber	PROPN
mkg-795	27	10	dan	dan	PROPN
mkg-795	27	11	uji	uji	PROPN
mkg-795	27	12	mtt	mtt	X
mkg-795	27	13	.	.	PUNCT
mkg-795	28	1	hasil	hasil	PROPN
mkg-795	28	2	:	:	PUNCT
mkg-795	29	1	pertumbuhan	pertumbuhan	NOUN
mkg-795	29	2	sel	sel	INTJ
mkg-795	30	1	hi	hi	INTJ
mkg-795	30	2	yang	yang	PROPN
mkg-795	30	3	ditransfeksi	ditransfeksi	PROPN
mkg-795	30	4	p45skp2	p45skp2	NOUN
mkg-795	30	5	as	as	ADP
mkg-795	30	6	menurun	menurun	NOUN
mkg-795	30	7	secara	secara	PROPN
mkg-795	30	8	signifikan	signifikan	PROPN
mkg-795	30	9	dibandingkan	dibandingkan	PROPN
mkg-795	30	10	dengan	dengan	PROPN
mkg-795	30	11	p45skp2	p45skp2	ADJ
mkg-795	30	12	sense	sense	NOUN
mkg-795	30	13	(	(	PUNCT
mkg-795	30	14	s	s	NOUN
mkg-795	30	15	)	)	PUNCT
mkg-795	30	16	(	(	PUNCT
mkg-795	30	17	p<0,05	p<0,05	NOUN
mkg-795	30	18	)	)	PUNCT
mkg-795	30	19	.	.	PUNCT
mkg-795	31	1	sel	sel	PROPN
mkg-795	31	2	hi	hi	INTJ
mkg-795	31	3	transfeksi	transfeksi	NOUN
mkg-795	31	4	p45skp2	p45skp2	NOUN
mkg-795	31	5	as	as	ADP
mkg-795	31	6	menginduksi	menginduksi	ADJ
mkg-795	31	7	apoptosis	apoptosis	NOUN
mkg-795	31	8	dengan	dengan	PROPN
mkg-795	31	9	meningkatkan	meningkatkan	PROPN
mkg-795	31	10	aktivitas	aktivitas	PROPN
mkg-795	31	11	proteolitik	proteolitik	PROPN
mkg-795	31	12	caspase-3	caspase-3	NUM
mkg-795	31	13	dan	dan	PROPN
mkg-795	31	14	early	early	ADJ
mkg-795	31	15	and	and	CCONJ
mkg-795	31	16	late	late	ADJ
mkg-795	31	17	apoptosis	apoptosis	NOUN
mkg-795	31	18	(	(	PUNCT
mkg-795	31	19	p<0,05	p<0,05	NOUN
mkg-795	31	20	)	)	PUNCT
mkg-795	31	21	.	.	PUNCT
mkg-795	32	1	hambatan	hambatan	PROPN
mkg-795	32	2	invasi	invasi	PROPN
mkg-795	32	3	dan	dan	PROPN
mkg-795	32	4	pertumbuhan	pertumbuhan	PROPN
mkg-795	32	5	sel	sel	PROPN
mkg-795	33	1	hi	hi	INTJ
mkg-795	33	2	secara	secara	PROPN
mkg-795	33	3	signifikan	signifikan	PROPN
mkg-795	33	4	meningkat	meningkat	PROPN
mkg-795	33	5	pada	pada	PROPN
mkg-795	33	6	sel	sel	PROPN
mkg-795	33	7	yang	yang	PROPN
mkg-795	33	8	diperlakukan	diperlakukan	PROPN
mkg-795	33	9	dengan	dengan	PROPN
mkg-795	33	10	p45skp2	p45skp2	PROPN
mkg-795	33	11	as	as	ADP
mkg-795	33	12	(	(	PUNCT
mkg-795	33	13	p<0,05	p<0,05	NOUN
mkg-795	33	14	)	)	PUNCT
mkg-795	33	15	.	.	PUNCT
mkg-795	34	1	kesimpulan	kesimpulan	PROPN
mkg-795	34	2	:	:	PUNCT
mkg-795	35	1	p45skp2	p45skp2	NOUN
mkg-795	35	2	as	as	SCONJ
mkg-795	35	3	oligonukleotida	oligonukleotida	PROPN
mkg-795	35	4	mempunyai	mempunyai	PROPN
mkg-795	35	5	aktivitas	aktivitas	PROPN
mkg-795	35	6	antitumor	antitumor	PROPN
mkg-795	35	7	yang	yang	PROPN
mkg-795	35	8	kuat	kuat	PROPN
mkg-795	35	9	pada	pada	PROPN
mkg-795	35	10	sel	sel	PROPN
mkg-795	35	11	kanker	kanker	PROPN
mkg-795	35	12	palatum	palatum	NOUN
mkg-795	35	13	lunak	lunak	NOUN
mkg-795	35	14	.	.	PUNCT
mkg-795	36	1	target	target	NOUN
mkg-795	36	2	dari	dari	PROPN
mkg-795	36	3	molekul	molekul	PROPN
mkg-795	36	4	tersebut	tersebut	PROPN
mkg-795	36	5	dapat	dapat	PROPN
mkg-795	36	6	menjanjikan	menjanjikan	PROPN
mkg-795	36	7	suatu	suatu	PROPN
mkg-795	36	8	terapeutik	terapeutik	PROPN
mkg-795	36	9	baru	baru	PROPN
mkg-795	36	10	untuk	untuk	PROPN
mkg-795	36	11	jenis	jenis	PROPN
mkg-795	36	12	kanker	kanker	PROPN
mkg-795	36	13	palatum	palatum	PROPN
mkg-795	36	14	tersebut	tersebut	PROPN
mkg-795	36	15	.	.	PUNCT
mkg-795	37	1	kata	kata	PROPN
mkg-795	37	2	kunci	kunci	PROPN
mkg-795	37	3	:	:	PUNCT
mkg-795	37	4	gen	gen	PROPN
mkg-795	37	5	p45skp2	p45skp2	NOUN
mkg-795	37	6	as	as	ADP
mkg-795	37	7	,	,	PUNCT
mkg-795	37	8	apoptosis	apoptosis	NOUN
mkg-795	37	9	,	,	PUNCT
mkg-795	37	10	invasi	invasi	ADJ
mkg-795	37	11	,	,	PUNCT
mkg-795	37	12	sel	sel	PROPN
mkg-795	37	13	kanker	kanker	NOUN
mkg-795	37	14	palatum	palatum	PROPN
mkg-795	37	15	lunak	lunak	PROPN
mkg-795	37	16	research	research	PROPN
mkg-795	37	17	report	report	PROPN
mkg-795	37	18	�	�	PROPN
mkg-795	37	19	�	�	PROPN
mkg-795	37	20	supriatno	supriatno	PROPN
mkg-795	37	21	,	,	PUNCT
mkg-795	37	22	et	et	PROPN
mkg-795	37	23	al	al	PROPN
mkg-795	37	24	.	.	PROPN
mkg-795	37	25	,	,	PUNCT
mkg-795	37	26	:	:	PUNCT
mkg-795	37	27	antitumor	antitumor	PROPN
mkg-795	37	28	activity	activity	NOUN
mkg-795	37	29	of	of	ADP
mkg-795	37	30	antisense	antisense	NOUN
mkg-795	37	31	oligonucleotide	oligonucleotide	VERB
mkg-795	37	32	p45skp2	p45skp2	ADJ
mkg-795	37	33	soft	soft	ADJ
mkg-795	37	34	palate	palate	NOUN
mkg-795	37	35	cancer	cancer	NOUN
mkg-795	37	36	is	be	AUX
mkg-795	37	37	a	a	DET
mkg-795	37	38	rare	rare	ADJ
mkg-795	37	39	cancerous	cancerous	ADJ
mkg-795	37	40	growth	growth	NOUN
mkg-795	37	41	of	of	ADP
mkg-795	37	42	the	the	DET
mkg-795	37	43	mouth	mouth	NOUN
mkg-795	37	44	.	.	PUNCT
mkg-795	38	1	cancer	cancer	NOUN
mkg-795	38	2	of	of	ADP
mkg-795	38	3	the	the	DET
mkg-795	38	4	soft	soft	ADJ
mkg-795	38	5	palate	palate	NOUN
mkg-795	38	6	accounts	account	NOUN
mkg-795	38	7	for	for	ADP
mkg-795	38	8	approximately	approximately	ADV
mkg-795	38	9	2	2	NUM
mkg-795	38	10	%	%	NOUN
mkg-795	38	11	of	of	ADP
mkg-795	38	12	head	head	NOUN
mkg-795	38	13	and	and	CCONJ
mkg-795	38	14	neck	neck	NOUN
mkg-795	38	15	mucosal	mucosal	NOUN
mkg-795	38	16	malignancies	malignancy	NOUN
mkg-795	38	17	and	and	CCONJ
mkg-795	38	18	most	most	ADJ
mkg-795	38	19	cancer	cancer	NOUN
mkg-795	38	20	of	of	ADP
mkg-795	38	21	the	the	DET
mkg-795	38	22	palates	palate	NOUN
mkg-795	38	23	are	be	AUX
mkg-795	38	24	squamous	squamous	ADJ
mkg-795	38	25	cell	cell	NOUN
mkg-795	38	26	carcinoma	carcinoma	NOUN
mkg-795	38	27	(	(	PUNCT
mkg-795	38	28	scc).1	scc).1	PUNCT
mkg-795	38	29	human	human	ADJ
mkg-795	38	30	soft	soft	ADJ
mkg-795	38	31	palate	palate	NOUN
mkg-795	38	32	cancers	cancer	NOUN
mkg-795	38	33	are	be	AUX
mkg-795	38	34	characterized	characterize	VERB
mkg-795	38	35	by	by	ADP
mkg-795	38	36	a	a	DET
mkg-795	38	37	high	high	ADJ
mkg-795	38	38	degree	degree	NOUN
mkg-795	38	39	of	of	ADP
mkg-795	38	40	local	local	ADJ
mkg-795	38	41	invasion	invasion	NOUN
mkg-795	38	42	and	and	CCONJ
mkg-795	38	43	a	a	DET
mkg-795	38	44	high	high	ADJ
mkg-795	38	45	rate	rate	NOUN
mkg-795	38	46	of	of	ADP
mkg-795	38	47	metastases	metastasis	NOUN
mkg-795	38	48	to	to	ADP
mkg-795	38	49	the	the	DET
mkg-795	38	50	cervical	cervical	ADJ
mkg-795	38	51	lymph	lymph	NOUN
mkg-795	38	52	nodes	nod	VERB
mkg-795	38	53	.	.	PUNCT
mkg-795	39	1	moreover	moreover	ADV
mkg-795	39	2	,	,	PUNCT
mkg-795	39	3	human	human	ADJ
mkg-795	39	4	soft	soft	ADJ
mkg-795	39	5	palate	palate	NOUN
mkg-795	39	6	cancer	cancer	NOUN
mkg-795	39	7	frequently	frequently	ADV
mkg-795	39	8	shows	show	VERB
mkg-795	39	9	local	local	ADJ
mkg-795	39	10	recurrence	recurrence	NOUN
mkg-795	39	11	after	after	ADP
mkg-795	39	12	initial	initial	ADJ
mkg-795	39	13	treatment	treatment	NOUN
mkg-795	39	14	,	,	PUNCT
mkg-795	39	15	probably	probably	ADV
mkg-795	39	16	due	due	ADJ
mkg-795	39	17	to	to	ADP
mkg-795	39	18	micro	micro	ADJ
mkg-795	39	19	invasion	invasion	NOUN
mkg-795	39	20	and/or	and/or	CCONJ
mkg-795	39	21	metastasis	metastasis	NOUN
mkg-795	39	22	of	of	ADP
mkg-795	39	23	tumor	tumor	NOUN
mkg-795	39	24	cells	cell	NOUN
mkg-795	39	25	at	at	ADP
mkg-795	39	26	the	the	DET
mkg-795	39	27	primary	primary	NOUN
mkg-795	39	28	site.2	site.2	PROPN
mkg-795	39	29	despite	despite	SCONJ
mkg-795	39	30	advanced	advanced	ADJ
mkg-795	39	31	in	in	ADP
mkg-795	39	32	surgery	surgery	NOUN
mkg-795	39	33	,	,	PUNCT
mkg-795	39	34	radiotherapy	radiotherapy	NOUN
mkg-795	39	35	and	and	CCONJ
mkg-795	39	36	chemotherapy	chemotherapy	NOUN
mkg-795	39	37	,	,	PUNCT
mkg-795	39	38	the	the	DET
mkg-795	39	39	survival	survival	NOUN
mkg-795	39	40	of	of	ADP
mkg-795	39	41	patients	patient	NOUN
mkg-795	39	42	with	with	ADP
mkg-795	39	43	oral	oral	ADJ
mkg-795	39	44	cancers	cancer	NOUN
mkg-795	39	45	include	include	VERB
mkg-795	39	46	soft	soft	ADJ
mkg-795	39	47	palate	palate	NOUN
mkg-795	39	48	cancer	cancer	NOUN
mkg-795	39	49	has	have	AUX
mkg-795	39	50	not	not	PART
mkg-795	39	51	significantly	significantly	ADV
mkg-795	39	52	improved	improve	VERB
mkg-795	39	53	over	over	ADP
mkg-795	39	54	the	the	DET
mkg-795	39	55	past	past	ADJ
mkg-795	39	56	several	several	ADJ
mkg-795	39	57	decades	decade	NOUN
mkg-795	39	58	.	.	PUNCT
mkg-795	40	1	also	also	ADV
mkg-795	40	2	,	,	PUNCT
mkg-795	40	3	treatment	treatment	NOUN
mkg-795	40	4	options	option	NOUN
mkg-795	40	5	for	for	ADP
mkg-795	40	6	recurrent	recurrent	ADJ
mkg-795	40	7	or	or	CCONJ
mkg-795	40	8	refractory	refractory	NOUN
mkg-795	40	9	soft	soft	ADJ
mkg-795	40	10	palate	palate	NOUN
mkg-795	40	11	cancers	cancer	NOUN
mkg-795	40	12	are	be	AUX
mkg-795	40	13	limited.3	limited.3	ADV
mkg-795	40	14	furthermore	furthermore	ADV
mkg-795	40	15	,	,	PUNCT
mkg-795	40	16	the	the	DET
mkg-795	40	17	ratio	ratio	NOUN
mkg-795	40	18	of	of	ADP
mkg-795	40	19	mortality	mortality	NOUN
mkg-795	40	20	in	in	ADP
mkg-795	40	21	1980	1980	NUM
mkg-795	40	22	and	and	CCONJ
mkg-795	40	23	1990	1990	NUM
mkg-795	40	24	was	be	AUX
mkg-795	40	25	48	48	NUM
mkg-795	40	26	%	%	NOUN
mkg-795	40	27	and	and	CCONJ
mkg-795	40	28	47	47	NUM
mkg-795	40	29	%	%	NOUN
mkg-795	40	30	respectively,4	respectively,4	NOUN
mkg-795	40	31	and	and	CCONJ
mkg-795	40	32	the	the	DET
mkg-795	40	33	oral	oral	ADJ
mkg-795	40	34	cancer	cancer	NOUN
mkg-795	40	35	prognosis	prognosis	NOUN
mkg-795	40	36	has	have	AUX
mkg-795	40	37	not	not	PART
mkg-795	40	38	changed	change	VERB
mkg-795	40	39	during	during	ADP
mkg-795	40	40	the	the	DET
mkg-795	40	41	past	past	ADJ
mkg-795	40	42	10	10	NUM
mkg-795	40	43	years	year	NOUN
mkg-795	40	44	.	.	PUNCT
mkg-795	41	1	however	however	ADV
mkg-795	41	2	,	,	PUNCT
mkg-795	41	3	as	as	ADP
mkg-795	41	4	a	a	DET
mkg-795	41	5	new	new	ADJ
mkg-795	41	6	strategy	strategy	NOUN
mkg-795	41	7	for	for	ADP
mkg-795	41	8	refractory	refractory	NOUN
mkg-795	41	9	cancer	cancer	NOUN
mkg-795	41	10	,	,	PUNCT
mkg-795	41	11	gene	gene	NOUN
mkg-795	41	12	therapy	therapy	NOUN
mkg-795	41	13	is	be	AUX
mkg-795	41	14	watched	watch	VERB
mkg-795	41	15	with	with	ADP
mkg-795	41	16	keen	keen	ADJ
mkg-795	41	17	interest	interest	NOUN
mkg-795	41	18	.	.	PUNCT
mkg-795	42	1	p45	p45	PROPN
mkg-795	42	2	s	s	PROPN
mkg-795	42	3	-	-	PUNCT
mkg-795	42	4	phase	phase	NOUN
mkg-795	42	5	kinase	kinase	NOUN
mkg-795	42	6	associated	associate	VERB
mkg-795	42	7	protein	protein	NOUN
mkg-795	42	8	2	2	NUM
mkg-795	42	9	(	(	PUNCT
mkg-795	42	10	p45skp2	p45skp2	NOUN
mkg-795	42	11	or	or	CCONJ
mkg-795	42	12	skp2	skp2	ADJ
mkg-795	42	13	)	)	PUNCT
mkg-795	42	14	,	,	PUNCT
mkg-795	42	15	a	a	DET
mkg-795	42	16	member	member	NOUN
mkg-795	42	17	of	of	ADP
mkg-795	42	18	the	the	DET
mkg-795	42	19	f	f	PROPN
mkg-795	42	20	-	-	PUNCT
mkg-795	42	21	box	box	NOUN
mkg-795	42	22	family	family	NOUN
mkg-795	42	23	,	,	PUNCT
mkg-795	42	24	is	be	AUX
mkg-795	42	25	the	the	DET
mkg-795	42	26	substraterecognition	substraterecognition	NOUN
mkg-795	42	27	subunit	subunit	NOUN
mkg-795	42	28	of	of	ADP
mkg-795	42	29	the	the	DET
mkg-795	42	30	scfskp2	scfskp2	PROPN
mkg-795	42	31	ubiquitin	ubiquitin	PROPN
mkg-795	42	32	ligase	ligase	PROPN
mkg-795	42	33	complex.5	complex.5	PROPN
mkg-795	42	34	skp2	skp2	PROPN
mkg-795	42	35	has	have	AUX
mkg-795	42	36	been	be	AUX
mkg-795	42	37	implicated	implicate	VERB
mkg-795	42	38	in	in	ADP
mkg-795	42	39	ubiquitin	ubiquitin	ADJ
mkg-795	42	40	-	-	PUNCT
mkg-795	42	41	mediated	mediate	VERB
mkg-795	42	42	degradation	degradation	NOUN
mkg-795	42	43	of	of	ADP
mkg-795	42	44	the	the	DET
mkg-795	42	45	cyclin	cyclin	NOUN
mkg-795	42	46	-	-	PUNCT
mkg-795	42	47	dependent	dependent	ADJ
mkg-795	42	48	kinase	kinase	NOUN
mkg-795	42	49	(	(	PUNCT
mkg-795	42	50	cdk	cdk	PROPN
mkg-795	42	51	)	)	PUNCT
mkg-795	42	52	inhibitor	inhibitor	NOUN
mkg-795	42	53	p27kip1	p27kip1	PROPN
mkg-795	42	54	,	,	PUNCT
mkg-795	42	55	and	and	CCONJ
mkg-795	42	56	positively	positively	ADV
mkg-795	42	57	regulates	regulate	VERB
mkg-795	42	58	the	the	DET
mkg-795	42	59	g1	g1	PROPN
mkg-795	42	60	/	/	SYM
mkg-795	42	61	s	s	PART
mkg-795	42	62	transition.6	transition.6	VERB
mkg-795	42	63	the	the	DET
mkg-795	42	64	targeted	target	VERB
mkg-795	42	65	disruption	disruption	NOUN
mkg-795	42	66	of	of	ADP
mkg-795	42	67	skp2	skp2	PROPN
mkg-795	42	68	leads	lead	VERB
mkg-795	42	69	to	to	ADP
mkg-795	42	70	the	the	DET
mkg-795	42	71	accumulation	accumulation	NOUN
mkg-795	42	72	of	of	ADP
mkg-795	42	73	p27	p27	NOUN
mkg-795	42	74	and	and	CCONJ
mkg-795	42	75	cell	cell	NOUN
mkg-795	42	76	cycle	cycle	NOUN
mkg-795	42	77	arrest	arrest	NOUN
mkg-795	42	78	in	in	ADP
mkg-795	42	79	g1	g1	PROPN
mkg-795	42	80	.	.	PUNCT
mkg-795	43	1	over	over	ADP
mkg-795	43	2	expression	expression	NOUN
mkg-795	43	3	of	of	ADP
mkg-795	43	4	skp2	skp2	PROPN
mkg-795	43	5	has	have	AUX
mkg-795	43	6	been	be	AUX
mkg-795	43	7	observed	observe	VERB
mkg-795	43	8	in	in	ADP
mkg-795	43	9	various	various	ADJ
mkg-795	43	10	types	type	NOUN
mkg-795	43	11	of	of	ADP
mkg-795	43	12	human	human	ADJ
mkg-795	43	13	tumors	tumor	NOUN
mkg-795	43	14	.	.	PUNCT
mkg-795	44	1	elevated	elevated	ADJ
mkg-795	44	2	expression	expression	NOUN
mkg-795	44	3	of	of	ADP
mkg-795	44	4	skp2	skp2	PROPN
mkg-795	44	5	indicates	indicate	VERB
mkg-795	44	6	poor	poor	ADJ
mkg-795	44	7	prognoses	prognosis	NOUN
mkg-795	44	8	for	for	ADP
mkg-795	44	9	patients	patient	NOUN
mkg-795	44	10	with	with	ADP
mkg-795	44	11	colorectal,7	colorectal,7	NOUN
mkg-795	44	12	lymphoma,8	lymphoma,8	NOUN
mkg-795	44	13	gastric,9	gastric,9	NOUN
mkg-795	44	14	and	and	CCONJ
mkg-795	44	15	lung	lung	NOUN
mkg-795	44	16	cancers.10	cancers.10	NOUN
mkg-795	44	17	therefore	therefore	ADV
mkg-795	44	18	,	,	PUNCT
mkg-795	44	19	skp2	skp2	ADJ
mkg-795	44	20	knock	knock	NOUN
mkg-795	44	21	-	-	PUNCT
mkg-795	44	22	out	out	ADP
mkg-795	44	23	mice	mouse	NOUN
mkg-795	44	24	grow	grow	VERB
mkg-795	44	25	more	more	ADV
mkg-795	44	26	slowly	slowly	ADV
mkg-795	44	27	and	and	CCONJ
mkg-795	44	28	have	have	VERB
mkg-795	44	29	smaller	small	ADJ
mkg-795	44	30	organs	organ	NOUN
mkg-795	44	31	than	than	ADP
mkg-795	44	32	littermate	littermate	NOUN
mkg-795	44	33	controls	control	NOUN
mkg-795	44	34	,	,	PUNCT
mkg-795	44	35	and	and	CCONJ
mkg-795	44	36	they	they	PRON
mkg-795	44	37	show	show	VERB
mkg-795	44	38	a	a	DET
mkg-795	44	39	reduced	reduce	VERB
mkg-795	44	40	growth	growth	NOUN
mkg-795	44	41	rate	rate	NOUN
mkg-795	44	42	and	and	CCONJ
mkg-795	44	43	increased	increase	VERB
mkg-795	44	44	apoptosis.11	apoptosis.11	NOUN
mkg-795	44	45	however	however	ADV
mkg-795	44	46	,	,	PUNCT
mkg-795	44	47	the	the	DET
mkg-795	44	48	role	role	NOUN
mkg-795	44	49	of	of	ADP
mkg-795	44	50	skp2	skp2	PROPN
mkg-795	44	51	over	over	ADP
mkg-795	44	52	expression	expression	NOUN
mkg-795	44	53	in	in	ADP
mkg-795	44	54	cancer	cancer	NOUN
mkg-795	44	55	cells	cell	NOUN
mkg-795	44	56	or	or	CCONJ
mkg-795	44	57	the	the	DET
mkg-795	44	58	nature	nature	NOUN
mkg-795	44	59	of	of	ADP
mkg-795	44	60	its	its	PRON
mkg-795	44	61	contribution	contribution	NOUN
mkg-795	44	62	to	to	ADP
mkg-795	44	63	the	the	DET
mkg-795	44	64	malignant	malignant	ADJ
mkg-795	44	65	phenotype	phenotype	NOUN
mkg-795	44	66	is	be	AUX
mkg-795	44	67	little	little	ADV
mkg-795	44	68	known	know	VERB
mkg-795	44	69	.	.	PUNCT
mkg-795	45	1	in	in	ADP
mkg-795	45	2	the	the	DET
mkg-795	45	3	present	present	ADJ
mkg-795	45	4	study	study	NOUN
mkg-795	45	5	,	,	PUNCT
mkg-795	45	6	p45skp2	p45skp2	NOUN
mkg-795	45	7	was	be	AUX
mkg-795	45	8	combined	combine	VERB
mkg-795	45	9	with	with	ADP
mkg-795	45	10	antisense	antisense	NOUN
mkg-795	45	11	oligonucleotide	oligonucleotide	NOUN
mkg-795	45	12	.	.	PUNCT
mkg-795	46	1	this	this	DET
mkg-795	46	2	antisense	antisense	NOUN
mkg-795	46	3	is	be	AUX
mkg-795	46	4	designed	design	VERB
mkg-795	46	5	to	to	PART
mkg-795	46	6	hybridize	hybridize	VERB
mkg-795	46	7	to	to	ADP
mkg-795	46	8	their	their	PRON
mkg-795	46	9	specific	specific	ADJ
mkg-795	46	10	mrna	mrna	NOUN
mkg-795	46	11	target	target	NOUN
mkg-795	46	12	.	.	PUNCT
mkg-795	47	1	the	the	DET
mkg-795	47	2	hybrid	hybrid	ADJ
mkg-795	47	3	formation	formation	NOUN
mkg-795	47	4	causes	cause	VERB
mkg-795	47	5	a	a	DET
mkg-795	47	6	steric	steric	ADJ
mkg-795	47	7	block	block	NOUN
mkg-795	47	8	or	or	CCONJ
mkg-795	47	9	conformational	conformational	ADJ
mkg-795	47	10	obstacle	obstacle	NOUN
mkg-795	47	11	for	for	ADP
mkg-795	47	12	protein	protein	NOUN
mkg-795	47	13	translasion	translasion	NOUN
mkg-795	47	14	.	.	PUNCT
mkg-795	48	1	antisense	antisense	NOUN
mkg-795	48	2	oligonucleotides	oligonucleotide	NOUN
mkg-795	48	3	are	be	AUX
mkg-795	48	4	used	use	VERB
mkg-795	48	5	to	to	PART
mkg-795	48	6	knock	knock	VERB
mkg-795	48	7	down	down	ADP
mkg-795	48	8	protein	protein	NOUN
mkg-795	48	9	expression	expression	NOUN
mkg-795	48	10	by	by	ADP
mkg-795	48	11	inhibiting	inhibit	VERB
mkg-795	48	12	the	the	DET
mkg-795	48	13	translation	translation	NOUN
mkg-795	48	14	of	of	ADP
mkg-795	48	15	the	the	DET
mkg-795	48	16	mrna	mrna	NOUN
mkg-795	48	17	of	of	ADP
mkg-795	48	18	a	a	DET
mkg-795	48	19	desired	desire	VERB
mkg-795	48	20	target	target	NOUN
mkg-795	48	21	gene.12	gene.12	NOUN
mkg-795	48	22	the	the	DET
mkg-795	48	23	main	main	ADJ
mkg-795	48	24	purpose	purpose	NOUN
mkg-795	48	25	of	of	ADP
mkg-795	48	26	the	the	DET
mkg-795	48	27	study	study	NOUN
mkg-795	48	28	was	be	AUX
mkg-795	48	29	to	to	PART
mkg-795	48	30	examine	examine	VERB
mkg-795	48	31	the	the	DET
mkg-795	48	32	antitumor	antitumor	PROPN
mkg-795	48	33	activity	activity	NOUN
mkg-795	48	34	of	of	ADP
mkg-795	48	35	p45skp2	p45skp2	ADJ
mkg-795	48	36	antisense	antisense	NOUN
mkg-795	48	37	(	(	PUNCT
mkg-795	49	1	p45skp2	p45skp2	VERB
mkg-795	49	2	as	as	ADP
mkg-795	49	3	)	)	PUNCT
mkg-795	49	4	gene	gene	NOUN
mkg-795	49	5	therapy	therapy	NOUN
mkg-795	49	6	in	in	ADP
mkg-795	49	7	human	human	ADJ
mkg-795	49	8	soft	soft	ADJ
mkg-795	49	9	palate	palate	NOUN
mkg-795	49	10	[	[	PUNCT
mkg-795	49	11	hamakawa	hamakawa	NOUN
mkg-795	49	12	-	-	PUNCT
mkg-795	49	13	inoue	inoue	NOUN
mkg-795	49	14	(	(	PUNCT
mkg-795	49	15	hi	hi	INTJ
mkg-795	49	16	)	)	PUNCT
mkg-795	49	17	]	]	PUNCT
mkg-795	49	18	cancer	cancer	NOUN
mkg-795	49	19	cells	cell	NOUN
mkg-795	49	20	.	.	PUNCT
mkg-795	50	1	materials	material	NOUN
mkg-795	50	2	and	and	CCONJ
mkg-795	50	3	methods	method	NOUN
mkg-795	50	4	derivation	derivation	NOUN
mkg-795	50	5	of	of	ADP
mkg-795	50	6	the	the	DET
mkg-795	50	7	human	human	ADJ
mkg-795	50	8	soft	soft	ADJ
mkg-795	50	9	palate	palate	ADJ
mkg-795	50	10	cancer	cancer	NOUN
mkg-795	50	11	cell	cell	NOUN
mkg-795	50	12	line	line	NOUN
mkg-795	50	13	(	(	PUNCT
mkg-795	50	14	hi	hi	INTJ
mkg-795	50	15	)	)	PUNCT
mkg-795	50	16	has	have	AUX
mkg-795	50	17	been	be	AUX
mkg-795	50	18	described.13	described.13	PROPN
mkg-795	50	19	hi	hi	INTJ
mkg-795	50	20	cell	cell	NOUN
mkg-795	50	21	line	line	NOUN
mkg-795	50	22	was	be	AUX
mkg-795	50	23	cultured	cultured	ADJ
mkg-795	50	24	in	in	ADP
mkg-795	50	25	dulbecco	dulbecco	NOUN
mkg-795	50	26	’s	’s	PART
mkg-795	50	27	modified	modify	VERB
mkg-795	50	28	eagle	eagle	PROPN
mkg-795	50	29	medium	medium	NOUN
mkg-795	50	30	(	(	PUNCT
mkg-795	50	31	dmem	dmem	ADJ
mkg-795	50	32	,	,	PUNCT
mkg-795	50	33	sigma	sigma	PROPN
mkg-795	50	34	-	-	PUNCT
mkg-795	50	35	aldrich	aldrich	PROPN
mkg-795	50	36	,	,	PUNCT
mkg-795	50	37	usa	usa	PROPN
mkg-795	50	38	)	)	PUNCT
mkg-795	50	39	supplemented	supplement	VERB
mkg-795	50	40	with	with	ADP
mkg-795	50	41	10	10	NUM
mkg-795	50	42	%	%	NOUN
mkg-795	50	43	fetal	fetal	ADJ
mkg-795	50	44	calf	calf	NOUN
mkg-795	50	45	serum	serum	NOUN
mkg-795	50	46	(	(	PUNCT
mkg-795	50	47	fcs	fcs	PROPN
mkg-795	50	48	,	,	PUNCT
mkg-795	50	49	moregate	moregate	NOUN
mkg-795	50	50	biotech	biotech	NOUN
mkg-795	50	51	,	,	PUNCT
mkg-795	50	52	bulimba	bulimba	NOUN
mkg-795	50	53	,	,	PUNCT
mkg-795	50	54	australia	australia	PROPN
mkg-795	50	55	)	)	PUNCT
mkg-795	50	56	,	,	PUNCT
mkg-795	50	57	and	and	CCONJ
mkg-795	50	58	100	100	NUM
mkg-795	50	59	mg	mg	NUM
mkg-795	50	60	/	/	SYM
mkg-795	50	61	ml	ml	X
mkg-795	50	62	streptomycin	streptomycin	PROPN
mkg-795	50	63	,	,	PUNCT
mkg-795	50	64	100	100	NUM
mkg-795	50	65	u	u	NOUN
mkg-795	50	66	/	/	SYM
mkg-795	50	67	ml	ml	ADP
mkg-795	50	68	penicillin	penicillin	NOUN
mkg-795	50	69	(	(	PUNCT
mkg-795	50	70	invitrogen	invitrogen	PROPN
mkg-795	50	71	corp	corp	PROPN
mkg-795	50	72	.	.	PROPN
mkg-795	50	73	,	,	PUNCT
mkg-795	50	74	carlsbad	carlsbad	PROPN
mkg-795	50	75	,	,	PUNCT
mkg-795	50	76	ca	ca	PROPN
mkg-795	50	77	,	,	PUNCT
mkg-795	50	78	usa	usa	PROPN
mkg-795	50	79	)	)	PUNCT
mkg-795	50	80	.	.	PUNCT
mkg-795	51	1	the	the	DET
mkg-795	51	2	cultures	culture	NOUN
mkg-795	51	3	were	be	AUX
mkg-795	51	4	incubated	incubate	VERB
mkg-795	51	5	in	in	ADP
mkg-795	51	6	humidified	humidified	ADJ
mkg-795	51	7	atmosphere	atmosphere	NOUN
mkg-795	51	8	of	of	ADP
mkg-795	51	9	95	95	NUM
mkg-795	51	10	%	%	NOUN
mkg-795	51	11	air	air	NOUN
mkg-795	51	12	and	and	CCONJ
mkg-795	51	13	5	5	NUM
mkg-795	51	14	%	%	NOUN
mkg-795	51	15	c02	c02	NOUN
mkg-795	51	16	at	at	ADP
mkg-795	51	17	37	37	NUM
mkg-795	51	18	°	°	ADP
mkg-795	51	19	c.	c.	PROPN
mkg-795	51	20	furthermore	furthermore	ADV
mkg-795	51	21	,	,	PUNCT
mkg-795	51	22	two	two	NUM
mkg-795	51	23	oligonucleotides	oligonucleotide	NOUN
mkg-795	51	24	(	(	PUNCT
mkg-795	51	25	antisense	antisense	NOUN
mkg-795	51	26	and	and	CCONJ
mkg-795	51	27	sense	sense	NOUN
mkg-795	51	28	)	)	PUNCT
mkg-795	51	29	containing	contain	VERB
mkg-795	51	30	phosphorothioate	phosphorothioate	NOUN
mkg-795	51	31	backbone	backbone	NOUN
mkg-795	51	32	were	be	AUX
mkg-795	51	33	treated	treat	VERB
mkg-795	51	34	into	into	ADP
mkg-795	51	35	a	a	DET
mkg-795	51	36	soft	soft	ADJ
mkg-795	51	37	palate	palate	NOUN
mkg-795	51	38	cancer	cancer	NOUN
mkg-795	51	39	(	(	PUNCT
mkg-795	51	40	hi	hi	NOUN
mkg-795	51	41	)	)	PUNCT
mkg-795	51	42	cell	cell	NOUN
mkg-795	51	43	line	line	NOUN
mkg-795	51	44	that	that	PRON
mkg-795	51	45	had	have	AUX
mkg-795	51	46	exhibited	exhibit	VERB
mkg-795	51	47	overexpression	overexpression	NOUN
mkg-795	51	48	of	of	ADP
mkg-795	51	49	the	the	DET
mkg-795	51	50	protein	protein	NOUN
mkg-795	51	51	.	.	PUNCT
mkg-795	52	1	antisense	antisense	NOUN
mkg-795	52	2	experiments	experiment	NOUN
mkg-795	52	3	were	be	AUX
mkg-795	52	4	performed	perform	VERB
mkg-795	52	5	as	as	ADP
mkg-795	52	6	described	describe	VERB
mkg-795	52	7	previously.10	previously.10	PROPN
mkg-795	52	8	two	two	NUM
mkg-795	52	9	oligonucleotides	oligonucleotide	NOUN
mkg-795	52	10	containing	contain	VERB
mkg-795	52	11	phosphorothioate	phosphorothioate	NOUN
mkg-795	52	12	backbones	backbone	NOUN
mkg-795	52	13	were	be	AUX
mkg-795	52	14	synthesized	synthesize	VERB
mkg-795	52	15	as	as	SCONJ
mkg-795	52	16	follows	follow	VERB
mkg-795	52	17	:	:	PUNCT
mkg-795	52	18	as	as	ADP
mkg-795	52	19	,	,	PUNCT
mkg-795	52	20	5’-tcctgtgcatagcgtccgcaggccc	5’-tcctgtgcatagcgtccgcaggccc	NUM
mkg-795	52	21	–	–	PUNCT
mkg-795	52	22	3	3	NUM
mkg-795	52	23	’	'	PUNCT
mkg-795	52	24	(	(	PUNCT
mkg-795	52	25	as	as	ADP
mkg-795	52	26	direction	direction	NOUN
mkg-795	52	27	of	of	ADP
mkg-795	52	28	human	human	ADJ
mkg-795	52	29	skp2	skp2	ADJ
mkg-795	52	30	cdna	cdna	PROPN
mkg-795	52	31	nucleotides	nucleotide	NOUN
mkg-795	52	32	15	15	NUM
mkg-795	52	33	to	to	PART
mkg-795	52	34	40	40	NUM
mkg-795	52	35	)	)	PUNCT
mkg-795	52	36	;	;	PUNCT
mkg-795	52	37	s	s	X
mkg-795	52	38	,	,	PUNCT
mkg-795	52	39	5’-cccggacgcctgcgatacgtgtcct-3	5’-cccggacgcctgcgatacgtgtcct-3	NUM
mkg-795	52	40	’	'	PUNCT
mkg-795	52	41	(	(	PUNCT
mkg-795	52	42	s	s	VERB
mkg-795	52	43	for	for	ADP
mkg-795	52	44	as	as	ADP
mkg-795	52	45	)	)	PUNCT
mkg-795	52	46	.	.	PUNCT
mkg-795	53	1	the	the	DET
mkg-795	53	2	oligonucleotides	oligonucleotide	NOUN
mkg-795	53	3	were	be	AUX
mkg-795	53	4	delivered	deliver	VERB
mkg-795	53	5	into	into	ADP
mkg-795	53	6	hi	hi	ADJ
mkg-795	53	7	cell	cell	NOUN
mkg-795	53	8	line	line	NOUN
mkg-795	53	9	directly	directly	ADV
mkg-795	53	10	according	accord	VERB
mkg-795	53	11	to	to	ADP
mkg-795	53	12	the	the	DET
mkg-795	53	13	manufacturer	manufacturer	NOUN
mkg-795	53	14	’s	’s	PART
mkg-795	53	15	instructions	instruction	NOUN
mkg-795	53	16	(	(	PUNCT
mkg-795	53	17	biognostik	biognostik	PROPN
mkg-795	53	18	’s	’s	PART
mkg-795	53	19	antisense	antisense	NOUN
mkg-795	53	20	,	,	PUNCT
mkg-795	53	21	germany	germany	PROPN
mkg-795	53	22	)	)	PUNCT
mkg-795	53	23	.	.	PUNCT
mkg-795	54	1	the	the	DET
mkg-795	54	2	amount	amount	NOUN
mkg-795	54	3	of	of	ADP
mkg-795	54	4	replication	replication	NOUN
mkg-795	54	5	was	be	AUX
mkg-795	54	6	performed	perform	VERB
mkg-795	54	7	in	in	ADP
mkg-795	54	8	quartet	quartet	NOUN
mkg-795	54	9	.	.	PUNCT
mkg-795	55	1	moreover	moreover	ADV
mkg-795	55	2	,	,	PUNCT
mkg-795	55	3	hi	hi	ADJ
mkg-795	55	4	cell	cell	NOUN
mkg-795	55	5	line	line	NOUN
mkg-795	55	6	was	be	AUX
mkg-795	55	7	seeded	seed	VERB
mkg-795	55	8	on	on	ADP
mkg-795	55	9	100	100	NUM
mkg-795	55	10	mm	mm	NOUN
mkg-795	55	11	dish	dish	NOUN
mkg-795	55	12	(	(	PUNCT
mkg-795	55	13	falcon	falcon	PROPN
mkg-795	55	14	,	,	PUNCT
mkg-795	55	15	becton	becton	PROPN
mkg-795	55	16	dickinson	dickinson	PROPN
mkg-795	55	17	labware	labware	PROPN
mkg-795	55	18	,	,	PUNCT
mkg-795	55	19	lincoln	lincoln	PROPN
mkg-795	55	20	park	park	PROPN
mkg-795	55	21	,	,	PUNCT
mkg-795	55	22	nj	nj	PROPN
mkg-795	55	23	,	,	PUNCT
mkg-795	55	24	usa	usa	PROPN
mkg-795	55	25	)	)	PUNCT
mkg-795	55	26	at	at	ADP
mkg-795	55	27	2x105	2x105	NUM
mkg-795	55	28	cells	cell	NOUN
mkg-795	55	29	/	/	SYM
mkg-795	55	30	well	well	ADV
mkg-795	55	31	in	in	ADP
mkg-795	55	32	dmem	dmem	NOUN
mkg-795	55	33	containing	contain	VERB
mkg-795	55	34	10	10	NUM
mkg-795	55	35	%	%	NOUN
mkg-795	55	36	fcs	fc	NOUN
mkg-795	55	37	.	.	PUNCT
mkg-795	56	1	after	after	ADP
mkg-795	56	2	72	72	NUM
mkg-795	56	3	hours	hour	NOUN
mkg-795	56	4	,	,	PUNCT
mkg-795	56	5	the	the	DET
mkg-795	56	6	sticked	sticked	ADJ
mkg-795	56	7	and	and	CCONJ
mkg-795	56	8	floating	float	VERB
mkg-795	56	9	cells	cell	NOUN
mkg-795	56	10	were	be	AUX
mkg-795	56	11	collected	collect	VERB
mkg-795	56	12	in	in	ADP
mkg-795	56	13	conical	conical	ADJ
mkg-795	56	14	tube	tube	NOUN
mkg-795	56	15	(	(	PUNCT
mkg-795	56	16	falcon	falcon	PROPN
mkg-795	56	17	)	)	PUNCT
mkg-795	56	18	.	.	PUNCT
mkg-795	57	1	then	then	ADV
mkg-795	57	2	,	,	PUNCT
mkg-795	57	3	the	the	DET
mkg-795	57	4	cells	cell	NOUN
mkg-795	57	5	were	be	AUX
mkg-795	57	6	incubated	incubate	VERB
mkg-795	57	7	with	with	ADP
mkg-795	57	8	5	5	NUM
mkg-795	57	9	ml	ml	NOUN
mkg-795	57	10	fitc	fitc	NOUN
mkg-795	57	11	and	and	CCONJ
mkg-795	57	12	propidium	propidium	NOUN
mkg-795	57	13	iodine	iodine	NOUN
mkg-795	57	14	(	(	PUNCT
mkg-795	57	15	pi	pi	NOUN
mkg-795	57	16	)	)	PUNCT
mkg-795	57	17	in	in	ADP
mkg-795	57	18	500	500	NUM
mkg-795	57	19	ml	ml	NOUN
mkg-795	57	20	binding	bind	VERB
mkg-795	57	21	buffer	buffer	NOUN
mkg-795	57	22	.	.	PUNCT
mkg-795	58	1	flow	flow	NOUN
mkg-795	58	2	cytometry	cytometry	NOUN
mkg-795	58	3	was	be	AUX
mkg-795	58	4	analysed	analyse	VERB
mkg-795	58	5	by	by	ADP
mkg-795	58	6	a	a	DET
mkg-795	58	7	digital	digital	ADJ
mkg-795	58	8	flow	flow	NOUN
mkg-795	58	9	cytometry	cytometry	NOUN
mkg-795	58	10	system	system	NOUN
mkg-795	58	11	epics	epic	NOUN
mkg-795	58	12	(	(	PUNCT
mkg-795	58	13	coulter	coulter	PROPN
mkg-795	58	14	,	,	PUNCT
mkg-795	58	15	miami	miami	PROPN
mkg-795	58	16	,	,	PUNCT
mkg-795	58	17	fl	fl	PROPN
mkg-795	58	18	,	,	PUNCT
mkg-795	58	19	usa	usa	PROPN
mkg-795	58	20	)	)	PUNCT
mkg-795	58	21	.	.	PUNCT
mkg-795	59	1	next	next	ADV
mkg-795	59	2	,	,	PUNCT
mkg-795	59	3	caspase-3	caspase-3	NUM
mkg-795	59	4	activities	activity	NOUN
mkg-795	59	5	were	be	AUX
mkg-795	59	6	measured	measure	VERB
mkg-795	59	7	using	use	VERB
mkg-795	59	8	the	the	DET
mkg-795	59	9	colorimetric	colorimetric	ADJ
mkg-795	59	10	assay	assay	NOUN
mkg-795	59	11	kit	kit	NOUN
mkg-795	59	12	.	.	PUNCT
mkg-795	60	1	this	this	DET
mkg-795	60	2	test	test	NOUN
mkg-795	60	3	is	be	AUX
mkg-795	60	4	based	base	VERB
mkg-795	60	5	on	on	ADP
mkg-795	60	6	the	the	DET
mkg-795	60	7	addition	addition	NOUN
mkg-795	60	8	of	of	ADP
mkg-795	60	9	a	a	DET
mkg-795	60	10	caspase	caspase	NOUN
mkg-795	60	11	-	-	PUNCT
mkg-795	60	12	specific	specific	ADJ
mkg-795	60	13	peptide	peptide	NOUN
mkg-795	60	14	conjugated	conjugate	VERB
mkg-795	60	15	to	to	ADP
mkg-795	60	16	a	a	DET
mkg-795	60	17	color	color	NOUN
mkg-795	60	18	reporter	reporter	NOUN
mkg-795	60	19	molecule	molecule	NOUN
mkg-795	60	20	p	p	NOUN
mkg-795	60	21	-	-	PUNCT
mkg-795	60	22	nitroanilide	nitroanilide	NOUN
mkg-795	60	23	(	(	PUNCT
mkg-795	60	24	p	p	NOUN
mkg-795	60	25	-	-	PUNCT
mkg-795	60	26	na	na	NOUN
mkg-795	60	27	)	)	PUNCT
mkg-795	60	28	.	.	PUNCT
mkg-795	61	1	the	the	DET
mkg-795	61	2	cleavage	cleavage	NOUN
mkg-795	61	3	of	of	ADP
mkg-795	61	4	the	the	DET
mkg-795	61	5	peptide	peptide	NOUN
mkg-795	61	6	by	by	ADP
mkg-795	61	7	caspase	caspase	PROPN
mkg-795	61	8	releases	release	VERB
mkg-795	61	9	the	the	DET
mkg-795	61	10	chromophore	chromophore	NOUN
mkg-795	61	11	p	p	NOUN
mkg-795	61	12	-	-	PUNCT
mkg-795	61	13	na	na	NOUN
mkg-795	61	14	,	,	PUNCT
mkg-795	61	15	which	which	PRON
mkg-795	61	16	is	be	AUX
mkg-795	61	17	quantitated	quantitate	VERB
mkg-795	61	18	spectrophotometrically	spectrophotometrically	ADV
mkg-795	61	19	at	at	ADP
mkg-795	61	20	405	405	NUM
mkg-795	61	21	nm	nm	NOUN
mkg-795	61	22	.	.	PUNCT
mkg-795	62	1	briefly	briefly	ADV
mkg-795	62	2	,	,	PUNCT
mkg-795	62	3	equal	equal	ADJ
mkg-795	62	4	amounts	amount	NOUN
mkg-795	62	5	of	of	ADP
mkg-795	62	6	cell	cell	NOUN
mkg-795	62	7	extracts	extract	NOUN
mkg-795	62	8	prepared	prepare	VERB
mkg-795	62	9	from	from	ADP
mkg-795	62	10	hi	hi	ADJ
mkg-795	62	11	cell	cell	NOUN
mkg-795	62	12	line	line	NOUN
mkg-795	62	13	treated	treat	VERB
mkg-795	62	14	with	with	ADP
mkg-795	62	15	as	as	ADP
mkg-795	62	16	or	or	CCONJ
mkg-795	62	17	s	s	NOUN
mkg-795	62	18	were	be	AUX
mkg-795	62	19	incubated	incubate	VERB
mkg-795	62	20	with	with	ADP
mkg-795	62	21	the	the	DET
mkg-795	62	22	substrate	substrate	NOUN
mkg-795	62	23	(	(	PUNCT
mkg-795	62	24	dved	dved	NOUN
mkg-795	62	25	-	-	PUNCT
mkg-795	62	26	pna	pna	NOUN
mkg-795	62	27	)	)	PUNCT
mkg-795	62	28	in	in	ADP
mkg-795	62	29	the	the	DET
mkg-795	62	30	assay	assay	NOUN
mkg-795	62	31	buffer	buffer	NOUN
mkg-795	62	32	for	for	ADP
mkg-795	62	33	2	2	NUM
mkg-795	62	34	hours	hour	NOUN
mkg-795	62	35	at	at	ADP
mkg-795	62	36	37	37	NUM
mkg-795	62	37	°	°	ADP
mkg-795	62	38	c.	c.	NOUN
mkg-795	62	39	absorbance	absorbance	NOUN
mkg-795	62	40	was	be	AUX
mkg-795	62	41	measured	measure	VERB
mkg-795	62	42	at	at	ADP
mkg-795	62	43	405	405	NUM
mkg-795	62	44	nm	nm	NOUN
mkg-795	62	45	using	use	VERB
mkg-795	62	46	a	a	DET
mkg-795	62	47	microplate	microplate	NOUN
mkg-795	62	48	reader	reader	NOUN
mkg-795	62	49	(	(	PUNCT
mkg-795	62	50	bio	bio	NOUN
mkg-795	62	51	-	-	ADJ
mkg-795	62	52	rad	rad	PROPN
mkg-795	62	53	laboratories	laboratory	NOUN
mkg-795	62	54	,	,	PUNCT
mkg-795	62	55	hercules	hercule	NOUN
mkg-795	62	56	,	,	PUNCT
mkg-795	62	57	ca	ca	PROPN
mkg-795	62	58	,	,	PUNCT
mkg-795	62	59	usa	usa	PROPN
mkg-795	62	60	)	)	PUNCT
mkg-795	62	61	.	.	PUNCT
mkg-795	63	1	each	each	DET
mkg-795	63	2	determination	determination	NOUN
mkg-795	63	3	was	be	AUX
mkg-795	63	4	conducted	conduct	VERB
mkg-795	63	5	in	in	ADP
mkg-795	63	6	triplicate	triplicate	NOUN
mkg-795	63	7	.	.	PUNCT
mkg-795	64	1	furthermore	furthermore	ADV
mkg-795	64	2	,	,	PUNCT
mkg-795	64	3	hi	hi	ADJ
mkg-795	64	4	cell	cell	NOUN
mkg-795	64	5	line	line	NOUN
mkg-795	64	6	was	be	AUX
mkg-795	64	7	seeded	seed	VERB
mkg-795	64	8	on	on	ADP
mkg-795	64	9	96	96	NUM
mkg-795	64	10	-	-	PUNCT
mkg-795	64	11	well	well	NOUN
mkg-795	64	12	plates	plate	NOUN
mkg-795	64	13	(	(	PUNCT
mkg-795	64	14	falcon	falcon	PROPN
mkg-795	64	15	,	,	PUNCT
mkg-795	64	16	nj	nj	PROPN
mkg-795	64	17	,	,	PUNCT
mkg-795	64	18	usa	usa	PROPN
mkg-795	64	19	)	)	PUNCT
mkg-795	64	20	at	at	ADP
mkg-795	64	21	5	5	NUM
mkg-795	64	22	x	x	SYM
mkg-795	64	23	103	103	NUM
mkg-795	64	24	cells	cell	NOUN
mkg-795	64	25	per	per	ADP
mkg-795	64	26	well	well	ADV
mkg-795	64	27	in	in	ADP
mkg-795	64	28	dmem	dmem	NOUN
mkg-795	64	29	containing	contain	VERB
mkg-795	64	30	10	10	NUM
mkg-795	64	31	%	%	NOUN
mkg-795	64	32	fcs	fc	NOUN
mkg-795	64	33	,	,	PUNCT
mkg-795	64	34	the	the	DET
mkg-795	64	35	day	day	NOUN
mkg-795	64	36	before	before	ADP
mkg-795	64	37	treatment	treatment	NOUN
mkg-795	64	38	.	.	PUNCT
mkg-795	65	1	cell	cell	NOUN
mkg-795	65	2	line	line	NOUN
mkg-795	65	3	was	be	AUX
mkg-795	65	4	treated	treat	VERB
mkg-795	65	5	with	with	ADP
mkg-795	65	6	oligonucleotides	oligonucleotide	NOUN
mkg-795	65	7	at	at	ADP
mkg-795	65	8	final	final	ADJ
mkg-795	65	9	concentration	concentration	NOUN
mkg-795	65	10	100	100	NUM
mkg-795	65	11	mm	mm	NOUN
mkg-795	65	12	.	.	PUNCT
mkg-795	66	1	after	after	ADP
mkg-795	66	2	24	24	NUM
mkg-795	66	3	and	and	CCONJ
mkg-795	66	4	48	48	NUM
mkg-795	66	5	hours	hour	NOUN
mkg-795	66	6	,	,	PUNCT
mkg-795	66	7	the	the	DET
mkg-795	66	8	number	number	NOUN
mkg-795	66	9	of	of	ADP
mkg-795	66	10	cells	cell	NOUN
mkg-795	66	11	was	be	AUX
mkg-795	66	12	quantitated	quantitate	VERB
mkg-795	66	13	by	by	ADP
mkg-795	66	14	an	an	DET
mkg-795	66	15	assay	assay	NOUN
mkg-795	66	16	in	in	ADP
mkg-795	66	17	which	which	PRON
mkg-795	66	18	mtt	mtt	NOUN
mkg-795	66	19	;	;	PUNCT
mkg-795	66	20	3-(4,5	3-(4,5	X
mkg-795	66	21	-	-	PUNCT
mkg-795	66	22	dimethylthiazol-2corespondence	dimethylthiazol-2corespondence	NOUN
mkg-795	66	23	:	:	PUNCT
mkg-795	66	24	supriatno	supriatno	NOUN
mkg-795	66	25	,	,	PUNCT
mkg-795	66	26	c	c	X
mkg-795	66	27	/	/	SYM
mkg-795	66	28	o	o	NOUN
mkg-795	66	29	:	:	PUNCT
mkg-795	66	30	departemen	departemen	PROPN
mkg-795	66	31	penyakit	penyakit	PROPN
mkg-795	66	32	mulut	mulut	PROPN
mkg-795	66	33	,	,	PUNCT
mkg-795	66	34	fakultas	fakultas	PROPN
mkg-795	66	35	kedokteran	kedokteran	PROPN
mkg-795	66	36	gigi	gigi	PROPN
mkg-795	66	37	universitas	universitas	PROPN
mkg-795	66	38	gadjah	gadjah	PROPN
mkg-795	66	39	mada	mada	PROPN
mkg-795	66	40	.	.	PUNCT
mkg-795	67	1	jl	jl	PROPN
mkg-795	67	2	.	.	PROPN
mkg-795	68	1	denta	denta	PROPN
mkg-795	68	2	i	i	PRON
mkg-795	68	3	,	,	PUNCT
mkg-795	68	4	sekip	sekip	ADJ
mkg-795	68	5	utara	utara	NOUN
mkg-795	68	6	yogyakarta	yogyakarta	PROPN
mkg-795	68	7	55281	55281	NUM
mkg-795	68	8	,	,	PUNCT
mkg-795	68	9	indonesia	indonesia	PROPN
mkg-795	68	10	.	.	PUNCT
mkg-795	69	1	e	e	X
mkg-795	69	2	-	-	NOUN
mkg-795	69	3	mail	mail	NOUN
mkg-795	69	4	:	:	PUNCT
mkg-795	70	1	pridentagama_oncolog@yahoo.com	pridentagama_oncolog@yahoo.com	X
mkg-795	70	2	introduction	introduction	NOUN
mkg-795	70	3	�	�	PROPN
mkg-795	70	4	0	0	NUM
mkg-795	70	5	dent	dent	NOUN
mkg-795	70	6	.	.	PUNCT
mkg-795	71	1	j.	j.	PROPN
mkg-795	71	2	(	(	PUNCT
mkg-795	71	3	maj	maj	PROPN
mkg-795	71	4	.	.	PROPN
mkg-795	71	5	ked	ked	PROPN
mkg-795	71	6	.	.	PUNCT
mkg-795	72	1	gigi	gigi	PROPN
mkg-795	72	2	)	)	PUNCT
mkg-795	72	3	,	,	PUNCT
mkg-795	72	4	volume	volume	NOUN
mkg-795	72	5	46	46	NUM
mkg-795	72	6	number	number	NOUN
mkg-795	72	7	1	1	NUM
mkg-795	72	8	march	march	NOUN
mkg-795	72	9	2013	2013	NUM
mkg-795	72	10	:	:	PUNCT
mkg-795	72	11	18–22	18–22	NUM
mkg-795	72	12	yl)-2,5	yl)-2,5	NOUN
mkg-795	72	13	-	-	PUNCT
mkg-795	72	14	diphenytetrazolium	diphenytetrazolium	NOUN
mkg-795	72	15	bromide	bromide	NOUN
mkg-795	72	16	(	(	PUNCT
mkg-795	72	17	sigma	sigma	PROPN
mkg-795	72	18	-	-	PUNCT
mkg-795	72	19	aldrich	aldrich	NOUN
mkg-795	72	20	)	)	PUNCT
mkg-795	72	21	was	be	AUX
mkg-795	72	22	used	use	VERB
mkg-795	72	23	.	.	PUNCT
mkg-795	73	1	therefore	therefore	ADV
mkg-795	73	2	,	,	PUNCT
mkg-795	73	3	hi	hi	ADJ
mkg-795	73	4	cell	cell	NOUN
mkg-795	73	5	line	line	NOUN
mkg-795	73	6	(	(	PUNCT
mkg-795	73	7	5	5	NUM
mkg-795	73	8	x	x	SYM
mkg-795	73	9	105	105	NUM
mkg-795	73	10	cell	cell	NOUN
mkg-795	73	11	/	/	SYM
mkg-795	73	12	kit	kit	NOUN
mkg-795	73	13	)	)	PUNCT
mkg-795	73	14	was	be	AUX
mkg-795	73	15	seeded	seed	VERB
mkg-795	73	16	and	and	CCONJ
mkg-795	73	17	placed	place	VERB
mkg-795	73	18	in	in	ADP
mkg-795	73	19	the	the	DET
mkg-795	73	20	upper	upper	ADJ
mkg-795	73	21	compartment	compartment	NOUN
mkg-795	73	22	(	(	PUNCT
mkg-795	73	23	each	each	DET
mkg-795	73	24	well	well	ADV
mkg-795	73	25	was	be	AUX
mkg-795	73	26	50	50	NUM
mkg-795	73	27	ml	ml	NOUN
mkg-795	73	28	)	)	PUNCT
mkg-795	73	29	and	and	CCONJ
mkg-795	73	30	was	be	AUX
mkg-795	73	31	allowed	allow	VERB
mkg-795	73	32	to	to	PART
mkg-795	73	33	migrate	migrate	VERB
mkg-795	73	34	through	through	ADP
mkg-795	73	35	the	the	DET
mkg-795	73	36	pores	pore	NOUN
mkg-795	73	37	of	of	ADP
mkg-795	73	38	the	the	DET
mkg-795	73	39	membrane	membrane	NOUN
mkg-795	73	40	into	into	ADP
mkg-795	73	41	the	the	DET
mkg-795	73	42	lower	low	ADJ
mkg-795	73	43	compartment	compartment	NOUN
mkg-795	73	44	,	,	PUNCT
mkg-795	73	45	in	in	ADP
mkg-795	73	46	which	which	PRON
mkg-795	73	47	chemotactic	chemotactic	ADJ
mkg-795	73	48	agents	agent	NOUN
mkg-795	73	49	(	(	PUNCT
mkg-795	73	50	medium	medium	NOUN
mkg-795	73	51	+	+	X
mkg-795	73	52	p45skp2	p45skp2	ADJ
mkg-795	73	53	as	as	ADP
mkg-795	73	54	or	or	CCONJ
mkg-795	73	55	s	s	VERB
mkg-795	73	56	)	)	PUNCT
mkg-795	73	57	are	be	AUX
mkg-795	73	58	present	present	ADJ
mkg-795	73	59	.	.	PUNCT
mkg-795	74	1	after	after	ADP
mkg-795	74	2	an	an	DET
mkg-795	74	3	appropriate	appropriate	ADJ
mkg-795	74	4	incubation	incubation	NOUN
mkg-795	74	5	time	time	NOUN
mkg-795	74	6	(	(	PUNCT
mkg-795	74	7	24	24	NUM
mkg-795	74	8	hours	hour	NOUN
mkg-795	74	9	)	)	PUNCT
mkg-795	74	10	,	,	PUNCT
mkg-795	74	11	the	the	DET
mkg-795	74	12	membrane	membrane	NOUN
mkg-795	74	13	between	between	ADP
mkg-795	74	14	the	the	DET
mkg-795	74	15	two	two	NUM
mkg-795	74	16	compartments	compartment	NOUN
mkg-795	74	17	is	be	AUX
mkg-795	74	18	fixed	fix	VERB
mkg-795	74	19	and	and	CCONJ
mkg-795	74	20	stained	stain	VERB
mkg-795	74	21	,	,	PUNCT
mkg-795	74	22	and	and	CCONJ
mkg-795	74	23	the	the	DET
mkg-795	74	24	number	number	NOUN
mkg-795	74	25	of	of	ADP
mkg-795	74	26	cells	cell	NOUN
mkg-795	74	27	that	that	PRON
mkg-795	74	28	have	have	AUX
mkg-795	74	29	migrated	migrate	VERB
mkg-795	74	30	to	to	ADP
mkg-795	74	31	the	the	DET
mkg-795	74	32	lower	low	ADJ
mkg-795	74	33	side	side	NOUN
mkg-795	74	34	of	of	ADP
mkg-795	74	35	the	the	DET
mkg-795	74	36	membrane	membrane	NOUN
mkg-795	74	37	is	be	AUX
mkg-795	74	38	determined	determine	VERB
mkg-795	74	39	by	by	ADP
mkg-795	74	40	light	light	ADJ
mkg-795	74	41	microscope	microscope	NOUN
mkg-795	74	42	with	with	ADP
mkg-795	74	43	40x	40x	NOUN
mkg-795	74	44	magnitude	magnitude	NOUN
mkg-795	74	45	.	.	PUNCT
mkg-795	75	1	statistical	statistical	ADJ
mkg-795	75	2	differences	difference	NOUN
mkg-795	75	3	between	between	ADP
mkg-795	75	4	the	the	DET
mkg-795	75	5	mean	mean	NOUN
mkg-795	75	6	for	for	ADP
mkg-795	75	7	the	the	DET
mkg-795	75	8	different	different	ADJ
mkg-795	75	9	groups	group	NOUN
mkg-795	75	10	were	be	AUX
mkg-795	75	11	evaluated	evaluate	VERB
mkg-795	75	12	with	with	ADP
mkg-795	75	13	stat	stat	PROPN
mkg-795	75	14	view	view	VERB
mkg-795	75	15	4.5	4.5	NUM
mkg-795	75	16	(	(	PUNCT
mkg-795	75	17	abacus	abacus	PROPN
mkg-795	75	18	concepts	concept	NOUN
mkg-795	75	19	,	,	PUNCT
mkg-795	75	20	berkeley	berkeley	PROPN
mkg-795	75	21	,	,	PUNCT
mkg-795	75	22	ca	ca	NOUN
mkg-795	75	23	)	)	PUNCT
mkg-795	75	24	using	use	VERB
mkg-795	75	25	post	post	ADJ
mkg-795	75	26	-	-	ADJ
mkg-795	75	27	hoc	hoc	X
mkg-795	75	28	t	t	NOUN
mkg-795	75	29	-	-	PUNCT
mkg-795	75	30	test	test	NOUN
mkg-795	75	31	.	.	PUNCT
mkg-795	76	1	the	the	DET
mkg-795	76	2	significance	significance	NOUN
mkg-795	76	3	level	level	NOUN
mkg-795	76	4	was	be	AUX
mkg-795	76	5	set	set	VERB
mkg-795	76	6	at	at	ADP
mkg-795	76	7	5	5	NUM
mkg-795	76	8	%	%	NOUN
mkg-795	76	9	for	for	ADP
mkg-795	76	10	each	each	DET
mkg-795	76	11	analysis	analysis	NOUN
mkg-795	76	12	.	.	PUNCT
mkg-795	77	1	results	result	NOUN
mkg-795	77	2	to	to	PART
mkg-795	77	3	determine	determine	VERB
mkg-795	77	4	whether	whether	SCONJ
mkg-795	77	5	down	down	ADP
mkg-795	77	6	regulation	regulation	NOUN
mkg-795	77	7	of	of	ADP
mkg-795	77	8	p45skp2	p45skp2	VERB
mkg-795	77	9	protein	protein	NOUN
mkg-795	77	10	can	can	AUX
mkg-795	77	11	induce	induce	VERB
mkg-795	77	12	apoptosis	apoptosis	NOUN
mkg-795	77	13	,	,	PUNCT
mkg-795	77	14	flow	flow	NOUN
mkg-795	77	15	cytometry	cytometry	NOUN
mkg-795	77	16	analysis	analysis	NOUN
mkg-795	77	17	was	be	AUX
mkg-795	77	18	performed	perform	VERB
mkg-795	77	19	on	on	ADP
mkg-795	77	20	each	each	DET
mkg-795	77	21	transfectant	transfectant	NOUN
mkg-795	77	22	.	.	PUNCT
mkg-795	78	1	flow	flow	VERB
mkg-795	78	2	cytometry	cytometry	NOUN
mkg-795	78	3	analysis	analysis	NOUN
mkg-795	78	4	demonstrated	demonstrate	VERB
mkg-795	78	5	that	that	SCONJ
mkg-795	78	6	high	high	ADJ
mkg-795	78	7	percentage	percentage	NOUN
mkg-795	78	8	of	of	ADP
mkg-795	78	9	early	early	ADJ
mkg-795	78	10	apoptosis	apoptosis	NOUN
mkg-795	78	11	was	be	AUX
mkg-795	78	12	detected	detect	VERB
mkg-795	78	13	in	in	ADP
mkg-795	78	14	hi	hi	NOUN
mkg-795	78	15	-	-	NOUN
mkg-795	78	16	skp2	skp2	ADJ
mkg-795	78	17	as	as	ADP
mkg-795	78	18	(	(	PUNCT
mkg-795	78	19	33.5	33.5	NUM
mkg-795	78	20	%	%	NOUN
mkg-795	78	21	)	)	PUNCT
mkg-795	78	22	compared	compare	VERB
mkg-795	78	23	with	with	ADP
mkg-795	78	24	that	that	PRON
mkg-795	78	25	of	of	ADP
mkg-795	78	26	hi	hi	ADJ
mkg-795	78	27	-	-	ADJ
mkg-795	78	28	skp2	skp2	ADJ
mkg-795	78	29	s	s	PART
mkg-795	78	30	(	(	PUNCT
mkg-795	78	31	18.8	18.8	NUM
mkg-795	78	32	%	%	NOUN
mkg-795	78	33	)	)	PUNCT
mkg-795	78	34	.	.	PUNCT
mkg-795	79	1	however	however	ADV
mkg-795	79	2	,	,	PUNCT
mkg-795	79	3	slightly	slightly	ADV
mkg-795	79	4	high	high	ADJ
mkg-795	79	5	percentage	percentage	NOUN
mkg-795	79	6	of	of	ADP
mkg-795	79	7	late	late	ADJ
mkg-795	79	8	apoptosis	apoptosis	NOUN
mkg-795	79	9	was	be	AUX
mkg-795	79	10	detected	detect	VERB
mkg-795	79	11	in	in	ADP
mkg-795	79	12	hi	hi	NOUN
mkg-795	79	13	-	-	NOUN
mkg-795	79	14	skp2	skp2	ADJ
mkg-795	79	15	as	as	ADP
mkg-795	79	16	(	(	PUNCT
mkg-795	79	17	17.6	17.6	NUM
mkg-795	79	18	%	%	NOUN
mkg-795	79	19	)	)	PUNCT
mkg-795	79	20	(	(	PUNCT
mkg-795	79	21	figure	figure	NOUN
mkg-795	79	22	1	1	NUM
mkg-795	79	23	)	)	PUNCT
mkg-795	79	24	.	.	PUNCT
mkg-795	80	1	it	it	PRON
mkg-795	80	2	means	mean	VERB
mkg-795	80	3	hi	hi	ADJ
mkg-795	80	4	-	-	NOUN
mkg-795	80	5	skp2	skp2	ADJ
mkg-795	80	6	as	as	ADP
mkg-795	80	7	induced	induce	VERB
mkg-795	80	8	apoptosis	apoptosis	NOUN
mkg-795	80	9	in	in	ADP
mkg-795	80	10	both	both	CCONJ
mkg-795	80	11	early	early	ADJ
mkg-795	80	12	and	and	CCONJ
mkg-795	80	13	late	late	ADJ
mkg-795	80	14	level	level	NOUN
mkg-795	80	15	of	of	ADP
mkg-795	80	16	apoptosis	apoptosis	NOUN
mkg-795	80	17	.	.	PUNCT
mkg-795	81	1	the	the	DET
mkg-795	81	2	activity	activity	NOUN
mkg-795	81	3	of	of	ADP
mkg-795	81	4	caspase-3	caspase-3	NUM
mkg-795	81	5	in	in	ADP
mkg-795	81	6	hi	hi	PROPN
mkg-795	81	7	cells	cell	NOUN
mkg-795	81	8	treated	treat	VERB
mkg-795	81	9	with	with	ADP
mkg-795	81	10	oligonucleotide	oligonucleotide	NOUN
mkg-795	81	11	(	(	PUNCT
mkg-795	81	12	as	as	ADP
mkg-795	81	13	and	and	CCONJ
mkg-795	81	14	s	s	NOUN
mkg-795	81	15	)	)	PUNCT
mkg-795	81	16	for	for	ADP
mkg-795	81	17	48	48	NUM
mkg-795	81	18	hours	hour	NOUN
mkg-795	81	19	were	be	AUX
mkg-795	81	20	examined	examine	VERB
mkg-795	81	21	.	.	PUNCT
mkg-795	82	1	as	as	SCONJ
mkg-795	82	2	seen	see	VERB
mkg-795	82	3	in	in	ADP
mkg-795	82	4	figure	figure	NOUN
mkg-795	82	5	2	2	NUM
mkg-795	82	6	,	,	PUNCT
mkg-795	82	7	hi	hi	ADJ
mkg-795	82	8	-	-	NOUN
mkg-795	82	9	skp2	skp2	ADJ
mkg-795	82	10	as	as	SCONJ
mkg-795	82	11	increased	increase	VERB
mkg-795	82	12	caspase-3	caspase-3	NUM
mkg-795	82	13	proteolytic	proteolytic	ADJ
mkg-795	82	14	activity	activity	NOUN
mkg-795	82	15	(	(	PUNCT
mkg-795	82	16	>	>	X
mkg-795	82	17	1.75	1.75	NUM
mkg-795	82	18	fold	fold	NOUN
mkg-795	82	19	)	)	PUNCT
mkg-795	82	20	compared	compare	VERB
mkg-795	82	21	with	with	ADP
mkg-795	82	22	that	that	PRON
mkg-795	82	23	of	of	ADP
mkg-795	82	24	hi	hi	ADJ
mkg-795	82	25	-	-	ADJ
mkg-795	82	26	skp2	skp2	ADJ
mkg-795	82	27	s	s	PART
mkg-795	82	28	(	(	PUNCT
mkg-795	82	29	p<0.01	p<0.01	PROPN
mkg-795	82	30	)	)	PUNCT
mkg-795	82	31	.	.	PUNCT
mkg-795	83	1	it	it	PRON
mkg-795	83	2	means	mean	VERB
mkg-795	83	3	skp2	skp2	ADJ
mkg-795	83	4	as	as	SCONJ
mkg-795	83	5	was	be	AUX
mkg-795	83	6	significantly	significantly	ADV
mkg-795	83	7	induced	induce	VERB
mkg-795	83	8	the	the	DET
mkg-795	83	9	proteolitic	proteolitic	ADJ
mkg-795	83	10	activity	activity	NOUN
mkg-795	83	11	or	or	CCONJ
mkg-795	83	12	apoptosis	apoptosis	NOUN
mkg-795	83	13	of	of	ADP
mkg-795	83	14	hi	hi	INTJ
mkg-795	83	15	transfectant	transfectant	NOUN
mkg-795	83	16	cell	cell	NOUN
mkg-795	83	17	in	in	ADP
mkg-795	83	18	external	external	ADJ
mkg-795	83	19	pathway	pathway	NOUN
mkg-795	83	20	at	at	ADP
mkg-795	83	21	least	least	ADV
mkg-795	83	22	1.75	1.75	NUM
mkg-795	83	23	times	time	NOUN
mkg-795	83	24	compared	compare	VERB
mkg-795	83	25	that	that	PRON
mkg-795	83	26	of	of	ADP
mkg-795	83	27	skp2	skp2	PROPN
mkg-795	83	28	s.	s.	PROPN
mkg-795	83	29	relative	relative	ADJ
mkg-795	83	30	cell	cell	NOUN
mkg-795	83	31	number	number	NOUN
mkg-795	83	32	was	be	AUX
mkg-795	83	33	evaluated	evaluate	VERB
mkg-795	83	34	by	by	ADP
mkg-795	83	35	comparing	compare	VERB
mkg-795	83	36	the	the	DET
mkg-795	83	37	absorbance	absorbance	NOUN
mkg-795	83	38	in	in	ADP
mkg-795	83	39	each	each	DET
mkg-795	83	40	cell	cell	NOUN
mkg-795	83	41	using	use	VERB
mkg-795	83	42	mtt	mtt	NOUN
mkg-795	83	43	assay	assay	ADV
mkg-795	83	44	at	at	ADP
mkg-795	83	45	24	24	NUM
mkg-795	83	46	and	and	CCONJ
mkg-795	83	47	48	48	NUM
mkg-795	83	48	hours	hour	NOUN
mkg-795	83	49	.	.	PUNCT
mkg-795	84	1	relative	relative	ADJ
mkg-795	84	2	number	number	NOUN
mkg-795	84	3	of	of	ADP
mkg-795	84	4	cell	cell	NOUN
mkg-795	84	5	hi	hi	ADJ
mkg-795	84	6	-	-	NOUN
mkg-795	84	7	skp2	skp2	ADJ
mkg-795	84	8	as	as	SCONJ
mkg-795	84	9	decreased	decrease	VERB
mkg-795	84	10	significantly	significantly	ADV
mkg-795	84	11	when	when	SCONJ
mkg-795	84	12	compared	compare	VERB
mkg-795	84	13	to	to	ADP
mkg-795	84	14	cell	cell	NOUN
mkg-795	84	15	treated	treat	VERB
mkg-795	84	16	by	by	ADP
mkg-795	84	17	skp2	skp2	PROPN
mkg-795	84	18	s	s	PROPN
mkg-795	84	19	(	(	PUNCT
mkg-795	84	20	p<0.05	p<0.05	PROPN
mkg-795	84	21	)	)	PUNCT
mkg-795	84	22	(	(	PUNCT
mkg-795	84	23	figure	figure	NOUN
mkg-795	84	24	3	3	NUM
mkg-795	84	25	)	)	PUNCT
mkg-795	84	26	.	.	PUNCT
mkg-795	85	1	it	it	PRON
mkg-795	85	2	suggests	suggest	VERB
mkg-795	85	3	that	that	SCONJ
mkg-795	85	4	skp2	skp2	PROPN
mkg-795	85	5	as	as	SCONJ
mkg-795	85	6	was	be	AUX
mkg-795	85	7	markedly	markedly	ADV
mkg-795	85	8	suppressed	suppress	VERB
mkg-795	85	9	the	the	DET
mkg-795	85	10	hi	hi	ADJ
mkg-795	85	11	cell	cell	NOUN
mkg-795	85	12	growth	growth	NOUN
mkg-795	85	13	effectively	effectively	ADV
mkg-795	85	14	compared	compare	VERB
mkg-795	85	15	that	that	PRON
mkg-795	85	16	of	of	ADP
mkg-795	85	17	skp2	skp2	PROPN
mkg-795	85	18	s.	s.	PROPN
mkg-795	85	19	cell	cell	PROPN
mkg-795	85	20	invasion	invasion	NOUN
mkg-795	85	21	was	be	AUX
mkg-795	85	22	examined	examine	VERB
mkg-795	85	23	by	by	ADP
mkg-795	85	24	boyden	boyden	PROPN
mkg-795	85	25	chamber	chamber	PROPN
mkg-795	85	26	kit	kit	NOUN
mkg-795	85	27	for	for	ADP
mkg-795	85	28	24	24	NUM
mkg-795	85	29	hours	hour	NOUN
mkg-795	85	30	incubation	incubation	NOUN
mkg-795	85	31	.	.	PUNCT
mkg-795	86	1	as	as	SCONJ
mkg-795	86	2	seen	see	VERB
mkg-795	86	3	in	in	ADP
mkg-795	86	4	figure	figure	NOUN
mkg-795	86	5	4	4	NUM
mkg-795	86	6	,	,	PUNCT
mkg-795	86	7	hi	hi	ADJ
mkg-795	86	8	cell	cell	NOUN
mkg-795	86	9	transfected	transfecte	VERB
mkg-795	86	10	by	by	ADP
mkg-795	86	11	skp2	skp2	PROPN
mkg-795	86	12	-	-	PUNCT
mkg-795	86	13	as	as	ADV
mkg-795	86	14	was	be	AUX
mkg-795	86	15	markedly	markedly	ADV
mkg-795	86	16	decreased	decrease	VERB
mkg-795	86	17	the	the	DET
mkg-795	86	18	cell	cell	NOUN
mkg-795	86	19	invasion	invasion	NOUN
mkg-795	86	20	compared	compare	VERB
mkg-795	86	21	with	with	ADP
mkg-795	86	22	that	that	PRON
mkg-795	86	23	of	of	ADP
mkg-795	86	24	hi	hi	ADJ
mkg-795	86	25	-	-	ADJ
mkg-795	86	26	skp2	skp2	ADJ
mkg-795	86	27	s	s	PART
mkg-795	86	28	(	(	PUNCT
mkg-795	86	29	p<0.05	p<0.05	NOUN
mkg-795	86	30	)	)	PUNCT
mkg-795	86	31	.	.	PUNCT
mkg-795	87	1	it	it	PRON
mkg-795	87	2	means	mean	VERB
mkg-795	87	3	skp2	skp2	PROPN
mkg-795	87	4	-	-	PUNCT
mkg-795	87	5	as	as	SCONJ
mkg-795	87	6	has	have	AUX
mkg-795	87	7	strong	strong	ADJ
mkg-795	87	8	enough	enough	ADV
mkg-795	87	9	inhibiting	inhibit	VERB
mkg-795	87	10	the	the	DET
mkg-795	87	11	hi	hi	ADJ
mkg-795	87	12	cell	cell	NOUN
mkg-795	87	13	invasion	invasion	NOUN
mkg-795	87	14	compared	compare	VERB
mkg-795	87	15	with	with	ADP
mkg-795	87	16	that	that	PRON
mkg-795	87	17	of	of	ADP
mkg-795	87	18	skp2	skp2	PROPN
mkg-795	87	19	-	-	PUNCT
mkg-795	87	20	s.	s.	PROPN
mkg-795	87	21	18.8	18.8	NUM
mkg-795	87	22	%	%	NOUN
mkg-795	87	23	10.9	10.9	NUM
mkg-795	87	24	%	%	NOUN
mkg-795	87	25	33.5	33.5	NUM
mkg-795	87	26	%	%	NOUN
mkg-795	87	27	17.6	17.6	NUM
mkg-795	87	28	%	%	NOUN
mkg-795	87	29	hi	hi	ADJ
mkg-795	87	30	-	-	ADJ
mkg-795	87	31	skp2	skp2	ADJ
mkg-795	87	32	s	s	PART
mkg-795	87	33	hi	hi	ADJ
mkg-795	87	34	-	-	NOUN
mkg-795	87	35	skp2	skp2	ADJ
mkg-795	87	36	as	as	ADP
mkg-795	87	37	figure	figure	NOUN
mkg-795	87	38	1	1	NUM
mkg-795	87	39	.	.	PUNCT
mkg-795	87	40	percentages	percentage	NOUN
mkg-795	87	41	of	of	ADP
mkg-795	87	42	apoptotic	apoptotic	ADJ
mkg-795	87	43	cells	cell	NOUN
mkg-795	87	44	in	in	ADP
mkg-795	87	45	hi	hi	ADJ
mkg-795	87	46	-	-	ADJ
mkg-795	87	47	skp2	skp2	ADJ
mkg-795	87	48	oligonucleotide	oligonucleotide	NOUN
mkg-795	87	49	-	-	PUNCT
mkg-795	87	50	treated	treat	VERB
mkg-795	87	51	cell	cell	NOUN
mkg-795	87	52	.	.	PUNCT
mkg-795	88	1	0	0	NUM
mkg-795	88	2	0.5	0.5	NUM
mkg-795	88	3	1	1	NUM
mkg-795	88	4	1.5	1.5	NUM
mkg-795	88	5	2	2	NUM
mkg-795	88	6	2.5	2.5	NUM
mkg-795	88	7	skp2	skp2	NOUN
mkg-795	88	8	s	s	PART
mkg-795	88	9	skp2	skp2	ADJ
mkg-795	88	10	as	as	ADP
mkg-795	88	11	hi	hi	NOUN
mkg-795	88	12	cells	cell	NOUN
mkg-795	88	13	*	*	PUNCT
mkg-795	88	14	*	*	PUNCT
mkg-795	88	15	fold	fold	ADJ
mkg-795	88	16	increase	increase	NOUN
mkg-795	88	17	in	in	ADP
mkg-795	88	18	caspase-3	caspase-3	NUM
mkg-795	88	19	activity	activity	NOUN
mkg-795	88	20	figure	figure	NOUN
mkg-795	88	21	2	2	NUM
mkg-795	88	22	.	.	PUNCT
mkg-795	89	1	the	the	DET
mkg-795	89	2	proteolytic	proteolytic	ADJ
mkg-795	89	3	activity	activity	NOUN
mkg-795	89	4	of	of	ADP
mkg-795	89	5	caspase-3	caspase-3	NUM
mkg-795	89	6	in	in	ADP
mkg-795	89	7	hi	hi	ADJ
mkg-795	89	8	transfectant	transfectant	NOUN
mkg-795	89	9	cells	cell	NOUN
mkg-795	89	10	.	.	PUNCT
mkg-795	90	1	0	0	NUM
mkg-795	90	2	0.3	0.3	NUM
mkg-795	90	3	0.6	0.6	NUM
mkg-795	90	4	0.9	0.9	NUM
mkg-795	90	5	1.2	1.2	NUM
mkg-795	90	6	24	24	NUM
mkg-795	90	7	hours	hour	NOUN
mkg-795	90	8	48	48	NUM
mkg-795	90	9	hours	hour	NOUN
mkg-795	90	10	skp2	skp2	PROPN
mkg-795	90	11	sc	sc	PROPN
mkg-795	90	12	skp2	skp2	PROPN
mkg-795	90	13	as	as	ADP
mkg-795	90	14	*	*	PUNCT
mkg-795	90	15	*	*	PUNCT
mkg-795	90	16	*	*	PUNCT
mkg-795	90	17	hi	hi	INTJ
mkg-795	90	18	cell	cell	NOUN
mkg-795	90	19	relative	relative	ADJ
mkg-795	90	20	cell	cell	NOUN
mkg-795	90	21	number	number	NOUN
mkg-795	90	22	(	(	PUNCT
mkg-795	90	23	od	od	PROPN
mkg-795	90	24	540	540	NUM
mkg-795	90	25	)	)	PUNCT
mkg-795	90	26	figure	figure	NOUN
mkg-795	90	27	3	3	NUM
mkg-795	90	28	.	.	PUNCT
mkg-795	91	1	growth	growth	NOUN
mkg-795	91	2	of	of	ADP
mkg-795	91	3	hi	hi	NOUN
mkg-795	91	4	cell	cell	NOUN
mkg-795	91	5	transfectants	transfectant	NOUN
mkg-795	91	6	in	in	ADP
mkg-795	91	7	vitro	vitro	X
mkg-795	91	8	at	at	ADP
mkg-795	91	9	24	24	NUM
mkg-795	91	10	and	and	CCONJ
mkg-795	91	11	48	48	NUM
mkg-795	91	12	hours	hour	NOUN
mkg-795	91	13	.	.	PUNCT
mkg-795	92	1	0	0	NUM
mkg-795	92	2	20	20	NUM
mkg-795	92	3	40	40	NUM
mkg-795	92	4	60	60	NUM
mkg-795	92	5	80	80	NUM
mkg-795	92	6	100	100	NUM
mkg-795	92	7	120	120	NUM
mkg-795	92	8	skp2	skp2	PROPN
mkg-795	92	9	s	s	PART
mkg-795	92	10	skp2	skp2	ADJ
mkg-795	92	11	as	as	ADP
mkg-795	92	12	hi	hi	INTJ
mkg-795	92	13	cell	cell	NOUN
mkg-795	92	14	*	*	PUNCT
mkg-795	92	15	number	number	NOUN
mkg-795	92	16	of	of	ADP
mkg-795	92	17	cell	cell	NOUN
mkg-795	92	18	invasion	invasion	NOUN
mkg-795	92	19	figure	figure	NOUN
mkg-795	92	20	4	4	NUM
mkg-795	92	21	.	.	PUNCT
mkg-795	93	1	suppression	suppression	NOUN
mkg-795	93	2	of	of	ADP
mkg-795	93	3	hi	hi	ADJ
mkg-795	93	4	-	-	ADJ
mkg-795	93	5	skp2	skp2	ADJ
mkg-795	93	6	cells	cell	NOUN
mkg-795	93	7	invasion	invasion	NOUN
mkg-795	93	8	at	at	ADP
mkg-795	93	9	24	24	NUM
mkg-795	93	10	hours	hour	NOUN
mkg-795	93	11	incubation	incubation	NOUN
mkg-795	93	12	.	.	PUNCT
mkg-795	94	1	�	�	PROPN
mkg-795	94	2	�	�	PROPN
mkg-795	94	3	supriatno	supriatno	PROPN
mkg-795	94	4	,	,	PUNCT
mkg-795	94	5	et	et	PROPN
mkg-795	94	6	al	al	PROPN
mkg-795	94	7	.	.	PROPN
mkg-795	94	8	,	,	PUNCT
mkg-795	94	9	:	:	PUNCT
mkg-795	94	10	antitumor	antitumor	PROPN
mkg-795	94	11	activity	activity	NOUN
mkg-795	94	12	of	of	ADP
mkg-795	94	13	antisense	antisense	NOUN
mkg-795	94	14	oligonucleotide	oligonucleotide	NOUN
mkg-795	94	15	p45skp2	p45skp2	ADJ
mkg-795	94	16	discussion	discussion	NOUN
mkg-795	94	17	the	the	DET
mkg-795	94	18	strategy	strategy	NOUN
mkg-795	94	19	of	of	ADP
mkg-795	94	20	therapy	therapy	NOUN
mkg-795	94	21	with	with	ADP
mkg-795	94	22	skp2	skp2	PROPN
mkg-795	94	23	as	as	ADP
mkg-795	94	24	in	in	ADP
mkg-795	94	25	human	human	ADJ
mkg-795	94	26	head	head	NOUN
mkg-795	94	27	and	and	CCONJ
mkg-795	94	28	neck	neck	NOUN
mkg-795	94	29	cancer	cancer	NOUN
mkg-795	94	30	includes	include	VERB
mkg-795	94	31	human	human	ADJ
mkg-795	94	32	soft	soft	ADJ
mkg-795	94	33	palate	palate	NOUN
mkg-795	94	34	cancer	cancer	NOUN
mkg-795	94	35	becomes	become	VERB
mkg-795	94	36	the	the	DET
mkg-795	94	37	focus	focus	NOUN
mkg-795	94	38	of	of	ADP
mkg-795	94	39	attention	attention	NOUN
mkg-795	94	40	in	in	ADP
mkg-795	94	41	this	this	DET
mkg-795	94	42	decade	decade	NOUN
mkg-795	94	43	.	.	PUNCT
mkg-795	95	1	antisense	antisense	NOUN
mkg-795	95	2	oligonucleotides	oligonucleotide	NOUN
mkg-795	95	3	p45skp2	p45skp2	VERB
mkg-795	95	4	contained	contain	VERB
mkg-795	95	5	phosphorothioate	phosphorothioate	NOUN
mkg-795	95	6	backbone	backbone	NOUN
mkg-795	95	7	was	be	AUX
mkg-795	95	8	used	use	VERB
mkg-795	95	9	to	to	PART
mkg-795	95	10	knock	knock	VERB
mkg-795	95	11	down	down	ADP
mkg-795	95	12	protein	protein	NOUN
mkg-795	95	13	expression	expression	NOUN
mkg-795	95	14	by	by	ADP
mkg-795	95	15	inhibiting	inhibit	VERB
mkg-795	95	16	the	the	DET
mkg-795	95	17	translation	translation	NOUN
mkg-795	95	18	of	of	ADP
mkg-795	95	19	the	the	DET
mkg-795	95	20	mrna	mrna	NOUN
mkg-795	95	21	of	of	ADP
mkg-795	95	22	a	a	DET
mkg-795	95	23	desired	desire	VERB
mkg-795	95	24	target	target	NOUN
mkg-795	95	25	gene.12	gene.12	NOUN
mkg-795	95	26	antisense	antisense	NOUN
mkg-795	95	27	oligonucleotides	oligonucleotide	NOUN
mkg-795	95	28	are	be	AUX
mkg-795	95	29	synthesized	synthesize	VERB
mkg-795	95	30	in	in	ADP
mkg-795	95	31	the	the	DET
mkg-795	95	32	hope	hope	NOUN
mkg-795	95	33	that	that	SCONJ
mkg-795	95	34	they	they	PRON
mkg-795	95	35	can	can	AUX
mkg-795	95	36	be	be	AUX
mkg-795	95	37	used	use	VERB
mkg-795	95	38	as	as	ADP
mkg-795	95	39	therapeutic	therapeutic	ADJ
mkg-795	95	40	agents	agent	NOUN
mkg-795	95	41	-	-	PUNCT
mkg-795	95	42	blocking	block	VERB
mkg-795	95	43	disease	disease	NOUN
mkg-795	95	44	processes	process	NOUN
mkg-795	95	45	by	by	ADP
mkg-795	95	46	suppressing	suppress	VERB
mkg-795	95	47	the	the	DET
mkg-795	95	48	synthesis	synthesis	NOUN
mkg-795	95	49	of	of	ADP
mkg-795	95	50	a	a	DET
mkg-795	95	51	particular	particular	ADJ
mkg-795	95	52	protein	protein	NOUN
mkg-795	95	53	.	.	PUNCT
mkg-795	96	1	this	this	PRON
mkg-795	96	2	would	would	AUX
mkg-795	96	3	be	be	AUX
mkg-795	96	4	achieved	achieve	VERB
mkg-795	96	5	by	by	ADP
mkg-795	96	6	the	the	DET
mkg-795	96	7	binding	binding	NOUN
mkg-795	96	8	of	of	ADP
mkg-795	96	9	the	the	DET
mkg-795	96	10	antisense	antisense	NOUN
mkg-795	96	11	oligonucleotide	oligonucleotide	VERB
mkg-795	96	12	to	to	ADP
mkg-795	96	13	the	the	DET
mkg-795	96	14	mrna	mrna	NOUN
mkg-795	96	15	from	from	ADP
mkg-795	96	16	which	which	PRON
mkg-795	96	17	that	that	DET
mkg-795	96	18	protein	protein	NOUN
mkg-795	96	19	is	be	AUX
mkg-795	96	20	normally	normally	ADV
mkg-795	96	21	synthesized	synthesize	VERB
mkg-795	96	22	.	.	PUNCT
mkg-795	97	1	binding	bind	VERB
mkg-795	97	2	of	of	ADP
mkg-795	97	3	both	both	PRON
mkg-795	97	4	may	may	AUX
mkg-795	97	5	physically	physically	ADV
mkg-795	97	6	block	block	VERB
mkg-795	97	7	the	the	DET
mkg-795	97	8	ability	ability	NOUN
mkg-795	97	9	of	of	ADP
mkg-795	97	10	ribosomes	ribosome	NOUN
mkg-795	97	11	to	to	PART
mkg-795	97	12	move	move	VERB
mkg-795	97	13	along	along	ADP
mkg-795	97	14	the	the	DET
mkg-795	97	15	mrna	mrna	NOUN
mkg-795	97	16	or	or	CCONJ
mkg-795	97	17	simply	simply	ADV
mkg-795	97	18	hasten	hasten	VERB
mkg-795	97	19	the	the	DET
mkg-795	97	20	rate	rate	NOUN
mkg-795	97	21	at	at	ADP
mkg-795	97	22	which	which	PRON
mkg-795	97	23	the	the	DET
mkg-795	97	24	mrna	mrna	PROPN
mkg-795	97	25	is	be	AUX
mkg-795	97	26	degraded	degrade	VERB
mkg-795	97	27	within	within	ADP
mkg-795	97	28	the	the	DET
mkg-795	97	29	cytosol.14	cytosol.14	PROPN
mkg-795	97	30	in	in	ADP
mkg-795	97	31	order	order	NOUN
mkg-795	97	32	to	to	PART
mkg-795	97	33	be	be	AUX
mkg-795	97	34	useful	useful	ADJ
mkg-795	97	35	in	in	ADP
mkg-795	97	36	human	human	ADJ
mkg-795	97	37	therapy	therapy	NOUN
mkg-795	97	38	,	,	PUNCT
mkg-795	97	39	antisense	antisense	NOUN
mkg-795	97	40	oligonucleotides	oligonucleotide	NOUN
mkg-795	97	41	must	must	AUX
mkg-795	97	42	be	be	AUX
mkg-795	97	43	able	able	ADJ
mkg-795	97	44	to	to	PART
mkg-795	97	45	enter	enter	VERB
mkg-795	97	46	the	the	DET
mkg-795	97	47	target	target	NOUN
mkg-795	97	48	cells	cell	NOUN
mkg-795	97	49	;	;	PUNCT
mkg-795	97	50	avoid	avoid	VERB
mkg-795	97	51	digestion	digestion	NOUN
mkg-795	97	52	by	by	ADP
mkg-795	97	53	nucleases	nuclease	NOUN
mkg-795	97	54	,	,	PUNCT
mkg-795	97	55	and	and	CCONJ
mkg-795	97	56	not	not	PART
mkg-795	97	57	cause	cause	VERB
mkg-795	97	58	dangerous	dangerous	ADJ
mkg-795	97	59	sideeffects	sideeffect	NOUN
mkg-795	97	60	.	.	PUNCT
mkg-795	98	1	to	to	PART
mkg-795	98	2	achieve	achieve	VERB
mkg-795	98	3	these	these	DET
mkg-795	98	4	goals	goal	NOUN
mkg-795	98	5	,	,	PUNCT
mkg-795	98	6	antisense	antisense	NOUN
mkg-795	98	7	oligonucleotides	oligonucleotide	NOUN
mkg-795	98	8	are	be	AUX
mkg-795	98	9	generally	generally	ADV
mkg-795	98	10	chemically	chemically	ADV
mkg-795	98	11	modified	modify	VERB
mkg-795	98	12	to	to	PART
mkg-795	98	13	resist	resist	VERB
mkg-795	98	14	digestion	digestion	NOUN
mkg-795	98	15	by	by	ADP
mkg-795	98	16	nucleases	nuclease	NOUN
mkg-795	98	17	,	,	PUNCT
mkg-795	98	18	attached	attach	VERB
mkg-795	98	19	to	to	ADP
mkg-795	98	20	a	a	DET
mkg-795	98	21	targeting	target	VERB
mkg-795	98	22	device	device	NOUN
mkg-795	98	23	such	such	ADJ
mkg-795	98	24	as	as	ADP
mkg-795	98	25	the	the	DET
mkg-795	98	26	ligand	ligand	NOUN
mkg-795	98	27	for	for	ADP
mkg-795	98	28	the	the	DET
mkg-795	98	29	type	type	NOUN
mkg-795	98	30	of	of	ADP
mkg-795	98	31	receptors	receptor	NOUN
mkg-795	98	32	found	find	VERB
mkg-795	98	33	on	on	ADP
mkg-795	98	34	desired	desire	VERB
mkg-795	98	35	target	target	NOUN
mkg-795	98	36	cells	cell	NOUN
mkg-795	98	37	,	,	PUNCT
mkg-795	98	38	antibodies	antibody	NOUN
mkg-795	98	39	directed	direct	VERB
mkg-795	98	40	against	against	ADP
mkg-795	98	41	molecules	molecule	NOUN
mkg-795	98	42	on	on	ADP
mkg-795	98	43	the	the	DET
mkg-795	98	44	surface	surface	NOUN
mkg-795	98	45	of	of	ADP
mkg-795	98	46	the	the	DET
mkg-795	98	47	desired	desire	VERB
mkg-795	98	48	target	target	NOUN
mkg-795	98	49	cells	cell	NOUN
mkg-795	98	50	.	.	PUNCT
mkg-795	99	1	several	several	ADJ
mkg-795	99	2	commercial	commercial	ADJ
mkg-795	99	3	factories	factory	NOUN
mkg-795	99	4	are	be	AUX
mkg-795	99	5	presently	presently	ADV
mkg-795	99	6	examining	examine	VERB
mkg-795	99	7	antisense	antisense	NOUN
mkg-795	99	8	oligonucleotides	oligonucleotide	NOUN
mkg-795	99	9	as	as	ADP
mkg-795	99	10	weapons	weapon	NOUN
mkg-795	99	11	against	against	ADP
mkg-795	99	12	:	:	PUNCT
mkg-795	99	13	hiv	hiv	PROPN
mkg-795	99	14	/	/	SYM
mkg-795	99	15	aids	aids	PROPN
mkg-795	99	16	,	,	PUNCT
mkg-795	99	17	human	human	ADJ
mkg-795	99	18	cytomegalovirus	cytomegalovirus	NOUN
mkg-795	99	19	(	(	PUNCT
mkg-795	99	20	hcmv	hcmv	NOUN
mkg-795	99	21	)	)	PUNCT
mkg-795	99	22	,	,	PUNCT
mkg-795	99	23	asthma	asthma	NOUN
mkg-795	99	24	,	,	PUNCT
mkg-795	99	25	several	several	ADJ
mkg-795	99	26	cancers	cancer	NOUN
mkg-795	99	27	include	include	VERB
mkg-795	99	28	chronic	chronic	ADJ
mkg-795	99	29	myelogenous	myelogenous	ADJ
mkg-795	99	30	leukemia	leukemia	NOUN
mkg-795	99	31	,	,	PUNCT
mkg-795	99	32	and	and	CCONJ
mkg-795	99	33	inflammation	inflammation	NOUN
mkg-795	99	34	caused	cause	VERB
mkg-795	99	35	by	by	ADP
mkg-795	99	36	cell	cell	NOUN
mkg-795	99	37	-	-	PUNCT
mkg-795	99	38	mediated	mediate	VERB
mkg-795	99	39	immune	immune	ADJ
mkg-795	99	40	reactions.15	reactions.15	NOUN
mkg-795	99	41	in	in	ADP
mkg-795	99	42	the	the	DET
mkg-795	99	43	present	present	ADJ
mkg-795	99	44	study	study	NOUN
mkg-795	99	45	,	,	PUNCT
mkg-795	99	46	an	an	DET
mkg-795	99	47	antisense	antisense	NOUN
mkg-795	99	48	strategy	strategy	NOUN
mkg-795	99	49	to	to	PART
mkg-795	99	50	investigate	investigate	VERB
mkg-795	99	51	the	the	DET
mkg-795	99	52	effect	effect	NOUN
mkg-795	99	53	of	of	ADP
mkg-795	99	54	skp2	skp2	NOUN
mkg-795	99	55	on	on	ADP
mkg-795	99	56	growth	growth	NOUN
mkg-795	99	57	of	of	ADP
mkg-795	99	58	human	human	ADJ
mkg-795	99	59	soft	soft	ADJ
mkg-795	99	60	palate	palate	NOUN
mkg-795	99	61	cancer	cancer	NOUN
mkg-795	99	62	that	that	PRON
mkg-795	99	63	was	be	AUX
mkg-795	99	64	overexpressing	overexpresse	VERB
mkg-795	99	65	this	this	DET
mkg-795	99	66	gene	gene	NOUN
mkg-795	99	67	was	be	AUX
mkg-795	99	68	employed	employ	VERB
mkg-795	99	69	.	.	PUNCT
mkg-795	100	1	transfection	transfection	NOUN
mkg-795	100	2	of	of	ADP
mkg-795	100	3	an	an	DET
mkg-795	100	4	antisense	antisense	NOUN
mkg-795	100	5	oligonucleotide	oligonucleotide	NOUN
mkg-795	100	6	skp2	skp2	PROPN
mkg-795	100	7	into	into	ADP
mkg-795	100	8	hi	hi	ADJ
mkg-795	100	9	cell	cell	NOUN
mkg-795	100	10	induced	induce	VERB
mkg-795	100	11	a	a	DET
mkg-795	100	12	decrease	decrease	NOUN
mkg-795	100	13	in	in	ADP
mkg-795	100	14	growth	growth	NOUN
mkg-795	100	15	inhibition	inhibition	NOUN
mkg-795	100	16	followed	follow	VERB
mkg-795	100	17	by	by	ADP
mkg-795	100	18	invasion	invasion	NOUN
mkg-795	100	19	cell	cell	NOUN
mkg-795	100	20	suppression	suppression	NOUN
mkg-795	100	21	.	.	PUNCT
mkg-795	101	1	these	these	DET
mkg-795	101	2	circumstances	circumstance	NOUN
mkg-795	101	3	,	,	PUNCT
mkg-795	101	4	together	together	ADV
mkg-795	101	5	with	with	ADP
mkg-795	101	6	observations	observation	NOUN
mkg-795	101	7	of	of	ADP
mkg-795	101	8	cell	cell	NOUN
mkg-795	101	9	death	death	NOUN
mkg-795	101	10	in	in	ADP
mkg-795	101	11	the	the	DET
mkg-795	101	12	skp2	skp2	ADJ
mkg-795	101	13	-	-	PUNCT
mkg-795	101	14	antisense	antisense	NOUN
mkg-795	101	15	treated	treat	VERB
mkg-795	101	16	cells	cell	NOUN
mkg-795	101	17	,	,	PUNCT
mkg-795	101	18	prompted	prompt	VERB
mkg-795	101	19	us	we	PRON
mkg-795	101	20	to	to	PART
mkg-795	101	21	investigate	investigate	VERB
mkg-795	101	22	possible	possible	ADJ
mkg-795	101	23	involvement	involvement	NOUN
mkg-795	101	24	of	of	ADP
mkg-795	101	25	apoptotic	apoptotic	ADJ
mkg-795	101	26	mechanism	mechanism	NOUN
mkg-795	101	27	in	in	ADP
mkg-795	101	28	the	the	DET
mkg-795	101	29	inhibition	inhibition	NOUN
mkg-795	101	30	of	of	ADP
mkg-795	101	31	cell	cell	NOUN
mkg-795	101	32	growth	growth	NOUN
mkg-795	101	33	following	follow	VERB
mkg-795	101	34	antisense	antisense	NOUN
mkg-795	101	35	treatment	treatment	NOUN
mkg-795	101	36	.	.	PUNCT
mkg-795	102	1	an	an	DET
mkg-795	102	2	increase	increase	NOUN
mkg-795	102	3	in	in	ADP
mkg-795	102	4	early	early	ADJ
mkg-795	102	5	and	and	CCONJ
mkg-795	102	6	late	late	ADJ
mkg-795	102	7	apoptosis	apoptosis	NOUN
mkg-795	102	8	percentage	percentage	NOUN
mkg-795	102	9	and	and	CCONJ
mkg-795	102	10	activation	activation	NOUN
mkg-795	102	11	of	of	ADP
mkg-795	102	12	caspase-3	caspase-3	NUM
mkg-795	102	13	in	in	ADP
mkg-795	102	14	as	as	ADV
mkg-795	102	15	-	-	PUNCT
mkg-795	102	16	treated	treat	VERB
mkg-795	102	17	cells	cell	NOUN
mkg-795	102	18	strongly	strongly	ADV
mkg-795	102	19	suggested	suggest	VERB
mkg-795	102	20	that	that	SCONJ
mkg-795	102	21	apoptosis	apoptosis	NOUN
mkg-795	102	22	had	have	AUX
mkg-795	102	23	occurred	occur	VERB
mkg-795	102	24	in	in	ADP
mkg-795	102	25	those	those	DET
mkg-795	102	26	cultures	culture	NOUN
mkg-795	102	27	.	.	PUNCT
mkg-795	103	1	activation	activation	NOUN
mkg-795	103	2	of	of	ADP
mkg-795	103	3	caspase-3	caspase-3	NUM
mkg-795	103	4	(	(	PUNCT
mkg-795	103	5	an	an	DET
mkg-795	103	6	executioner	executioner	NOUN
mkg-795	103	7	caspase	caspase	NOUN
mkg-795	103	8	in	in	ADP
mkg-795	103	9	the	the	DET
mkg-795	103	10	apoptosis	apoptosis	NOUN
mkg-795	103	11	pathway	pathway	NOUN
mkg-795	103	12	)	)	PUNCT
mkg-795	103	13	leads	lead	VERB
mkg-795	103	14	to	to	ADP
mkg-795	103	15	the	the	DET
mkg-795	103	16	cleavage	cleavage	NOUN
mkg-795	103	17	of	of	ADP
mkg-795	103	18	poly	poly	ADJ
mkg-795	103	19	(	(	PUNCT
mkg-795	103	20	adp	adp	PROPN
mkg-795	103	21	-	-	PUNCT
mkg-795	103	22	ribose	ribose	NOUN
mkg-795	103	23	)	)	PUNCT
mkg-795	103	24	polymerase	polymerase	NOUN
mkg-795	103	25	(	(	PUNCT
mkg-795	103	26	parp	parp	NOUN
mkg-795	103	27	)	)	PUNCT
mkg-795	103	28	and	and	CCONJ
mkg-795	103	29	dna	dna	PROPN
mkg-795	103	30	fragmentation	fragmentation	NOUN
mkg-795	103	31	,	,	PUNCT
mkg-795	103	32	indicating	indicate	VERB
mkg-795	103	33	that	that	SCONJ
mkg-795	103	34	caspase-3	caspase-3	NUM
mkg-795	103	35	targets	target	VERB
mkg-795	103	36	cellular	cellular	ADJ
mkg-795	103	37	proteins	protein	NOUN
mkg-795	103	38	for	for	ADP
mkg-795	103	39	proteolytic	proteolytic	ADJ
mkg-795	103	40	cleavage	cleavage	NOUN
mkg-795	103	41	that	that	PRON
mkg-795	103	42	results	result	VERB
mkg-795	103	43	in	in	ADP
mkg-795	103	44	cell	cell	NOUN
mkg-795	103	45	death	death	NOUN
mkg-795	103	46	.	.	PUNCT
mkg-795	104	1	caspase-3	caspase-3	NUM
mkg-795	104	2	can	can	AUX
mkg-795	104	3	be	be	AUX
mkg-795	104	4	activated	activate	VERB
mkg-795	104	5	by	by	ADP
mkg-795	104	6	either	either	CCONJ
mkg-795	104	7	an	an	DET
mkg-795	104	8	extrinsic	extrinsic	ADJ
mkg-795	104	9	apoptosis	apoptosis	NOUN
mkg-795	104	10	pathway	pathway	NOUN
mkg-795	104	11	,	,	PUNCT
mkg-795	104	12	by	by	ADP
mkg-795	104	13	the	the	DET
mkg-795	104	14	activation	activation	NOUN
mkg-795	104	15	of	of	ADP
mkg-795	104	16	caspase-8	caspase-8	PROPN
mkg-795	104	17	,	,	PUNCT
mkg-795	104	18	or	or	CCONJ
mkg-795	104	19	an	an	DET
mkg-795	104	20	intrinsic	intrinsic	ADJ
mkg-795	104	21	apoptosis	apoptosis	NOUN
mkg-795	104	22	pathway	pathway	NOUN
mkg-795	104	23	(	(	PUNCT
mkg-795	104	24	via	via	ADP
mkg-795	104	25	release	release	NOUN
mkg-795	104	26	of	of	ADP
mkg-795	104	27	cytochrome	cytochrome	NOUN
mkg-795	104	28	-	-	PUNCT
mkg-795	104	29	c	c	NOUN
mkg-795	104	30	from	from	ADP
mkg-795	104	31	mitochondria	mitochondria	PROPN
mkg-795	104	32	)	)	PUNCT
mkg-795	104	33	.	.	PUNCT
mkg-795	105	1	activated	activate	VERB
mkg-795	105	2	caspase-8	caspase-8	PRON
mkg-795	105	3	can	can	AUX
mkg-795	105	4	directly	directly	ADV
mkg-795	105	5	cleave	cleave	VERB
mkg-795	105	6	and	and	CCONJ
mkg-795	105	7	activate	activate	VERB
mkg-795	105	8	the	the	DET
mkg-795	105	9	executioner	executioner	NOUN
mkg-795	105	10	caspases	caspase	NOUN
mkg-795	105	11	,	,	PUNCT
mkg-795	105	12	such	such	ADJ
mkg-795	105	13	as	as	ADP
mkg-795	105	14	caspase-3	caspase-3	PROPN
mkg-795	105	15	.	.	PUNCT
mkg-795	106	1	alternatively	alternatively	ADV
mkg-795	106	2	,	,	PUNCT
mkg-795	106	3	it	it	PRON
mkg-795	106	4	can	can	AUX
mkg-795	106	5	cleave	cleave	VERB
mkg-795	106	6	one	one	NUM
mkg-795	106	7	of	of	ADP
mkg-795	106	8	the	the	DET
mkg-795	106	9	bcl-2	bcl-2	PUNCT
mkg-795	106	10	family	family	NOUN
mkg-795	106	11	members	member	NOUN
mkg-795	106	12	(	(	PUNCT
mkg-795	106	13	such	such	ADJ
mkg-795	106	14	as	as	ADP
mkg-795	106	15	bid	bid	NOUN
mkg-795	106	16	)	)	PUNCT
mkg-795	106	17	to	to	PART
mkg-795	106	18	induce	induce	VERB
mkg-795	106	19	the	the	DET
mkg-795	106	20	release	release	NOUN
mkg-795	106	21	of	of	ADP
mkg-795	106	22	mitochondrial	mitochondrial	ADJ
mkg-795	106	23	cytochrome	cytochrome	NOUN
mkg-795	106	24	c	c	NOUN
mkg-795	106	25	,	,	PUNCT
mkg-795	106	26	which	which	PRON
mkg-795	106	27	also	also	ADV
mkg-795	106	28	leads	lead	VERB
mkg-795	106	29	to	to	ADP
mkg-795	106	30	activation	activation	NOUN
mkg-795	106	31	of	of	ADP
mkg-795	106	32	caspase-3	caspase-3	NUM
mkg-795	106	33	via	via	ADP
mkg-795	106	34	formation	formation	NOUN
mkg-795	106	35	of	of	ADP
mkg-795	106	36	apoptosome	apoptosome	NOUN
mkg-795	106	37	(	(	PUNCT
mkg-795	106	38	consisting	consist	VERB
mkg-795	106	39	of	of	ADP
mkg-795	106	40	apaf-1	apaf-1	NUM
mkg-795	106	41	and	and	CCONJ
mkg-795	106	42	caspase-9).16	caspase-9).16	NOUN
mkg-795	106	43	in	in	ADP
mkg-795	106	44	the	the	DET
mkg-795	106	45	current	current	ADJ
mkg-795	106	46	study	study	NOUN
mkg-795	106	47	,	,	PUNCT
mkg-795	106	48	increased	increase	VERB
mkg-795	106	49	caspase-3	caspase-3	NUM
mkg-795	106	50	activation	activation	NOUN
mkg-795	106	51	in	in	ADP
mkg-795	106	52	as	as	ADV
mkg-795	106	53	-	-	PUNCT
mkg-795	106	54	treated	treat	VERB
mkg-795	106	55	cells	cell	NOUN
mkg-795	106	56	revealed	reveal	VERB
mkg-795	106	57	that	that	SCONJ
mkg-795	106	58	apoptosis	apoptosis	NOUN
mkg-795	106	59	ensured	ensure	VERB
mkg-795	106	60	extrinsic	extrinsic	ADJ
mkg-795	106	61	pathway	pathway	NOUN
mkg-795	106	62	.	.	PUNCT
mkg-795	107	1	in	in	ADP
mkg-795	107	2	fact	fact	NOUN
mkg-795	107	3	,	,	PUNCT
mkg-795	107	4	apoptosis	apoptosis	NOUN
mkg-795	107	5	was	be	AUX
mkg-795	107	6	originally	originally	ADV
mkg-795	107	7	described	describe	VERB
mkg-795	107	8	as	as	ADP
mkg-795	107	9	a	a	DET
mkg-795	107	10	mechanism	mechanism	NOUN
mkg-795	107	11	of	of	ADP
mkg-795	107	12	controlled	control	VERB
mkg-795	107	13	or	or	CCONJ
mkg-795	107	14	physiological	physiological	ADJ
mkg-795	107	15	cell	cell	NOUN
mkg-795	107	16	death	death	NOUN
mkg-795	107	17	.	.	PUNCT
mkg-795	108	1	it	it	PRON
mkg-795	108	2	is	be	AUX
mkg-795	108	3	associated	associate	VERB
mkg-795	108	4	with	with	ADP
mkg-795	108	5	the	the	DET
mkg-795	108	6	regulation	regulation	NOUN
mkg-795	108	7	of	of	ADP
mkg-795	108	8	cellular	cellular	ADJ
mkg-795	108	9	homeostasis	homeostasis	NOUN
mkg-795	108	10	in	in	ADP
mkg-795	108	11	organs	organ	NOUN
mkg-795	108	12	and	and	CCONJ
mkg-795	108	13	the	the	DET
mkg-795	108	14	elimination	elimination	NOUN
mkg-795	108	15	of	of	ADP
mkg-795	108	16	damaged	damage	VERB
mkg-795	108	17	cells	cell	NOUN
mkg-795	108	18	or	or	CCONJ
mkg-795	108	19	cells	cell	NOUN
mkg-795	108	20	with	with	ADP
mkg-795	108	21	deleterious	deleterious	ADJ
mkg-795	108	22	reactivities	reactivity	NOUN
mkg-795	108	23	from	from	ADP
mkg-795	108	24	the	the	DET
mkg-795	108	25	host	host	NOUN
mkg-795	108	26	.	.	PUNCT
mkg-795	109	1	apoptosis	apoptosis	NOUN
mkg-795	109	2	is	be	AUX
mkg-795	109	3	very	very	ADV
mkg-795	109	4	common	common	ADJ
mkg-795	109	5	in	in	ADP
mkg-795	109	6	organs	organ	NOUN
mkg-795	109	7	with	with	ADP
mkg-795	109	8	high	high	ADJ
mkg-795	109	9	proliferation	proliferation	NOUN
mkg-795	109	10	activity	activity	NOUN
mkg-795	109	11	and	and	CCONJ
mkg-795	109	12	in	in	ADP
mkg-795	109	13	tissue	tissue	NOUN
mkg-795	109	14	with	with	ADP
mkg-795	109	15	intense	intense	ADJ
mkg-795	109	16	hematopoietic	hematopoietic	ADJ
mkg-795	109	17	activity	activity	NOUN
mkg-795	109	18	.	.	PUNCT
mkg-795	110	1	additionally	additionally	ADV
mkg-795	110	2	,	,	PUNCT
mkg-795	110	3	apoptosis	apoptosis	NOUN
mkg-795	110	4	has	have	AUX
mkg-795	110	5	been	be	AUX
mkg-795	110	6	implicated	implicate	VERB
mkg-795	110	7	in	in	ADP
mkg-795	110	8	the	the	DET
mkg-795	110	9	progression	progression	NOUN
mkg-795	110	10	of	of	ADP
mkg-795	110	11	a	a	DET
mkg-795	110	12	number	number	NOUN
mkg-795	110	13	of	of	ADP
mkg-795	110	14	pathological	pathological	ADJ
mkg-795	110	15	conditions	condition	NOUN
mkg-795	110	16	,	,	PUNCT
mkg-795	110	17	including	include	VERB
mkg-795	110	18	cancer	cancer	NOUN
mkg-795	110	19	and	and	CCONJ
mkg-795	110	20	autoimmune	autoimmune	ADJ
mkg-795	110	21	diseases.17	diseases.17	NOUN
mkg-795	110	22	as	as	SCONJ
mkg-795	110	23	expected	expect	VERB
mkg-795	110	24	from	from	ADP
mkg-795	110	25	its	its	PRON
mkg-795	110	26	stronger	strong	ADJ
mkg-795	110	27	growth	growth	NOUN
mkg-795	110	28	inhibition	inhibition	NOUN
mkg-795	110	29	and	and	CCONJ
mkg-795	110	30	apoptosis	apoptosis	NOUN
mkg-795	110	31	induction	induction	NOUN
mkg-795	110	32	,	,	PUNCT
mkg-795	110	33	a	a	DET
mkg-795	110	34	significant	significant	ADJ
mkg-795	110	35	suppression	suppression	NOUN
mkg-795	110	36	of	of	ADP
mkg-795	110	37	tumor	tumor	NOUN
mkg-795	110	38	growth	growth	NOUN
mkg-795	110	39	was	be	AUX
mkg-795	110	40	detected	detect	VERB
mkg-795	110	41	in	in	ADP
mkg-795	110	42	hi	hi	NOUN
mkg-795	110	43	-	-	NOUN
mkg-795	110	44	skp2	skp2	ADJ
mkg-795	110	45	as	as	ADP
mkg-795	110	46	when	when	SCONJ
mkg-795	110	47	compared	compare	VERB
mkg-795	110	48	with	with	ADP
mkg-795	110	49	that	that	PRON
mkg-795	110	50	of	of	ADP
mkg-795	110	51	hi	hi	ADJ
mkg-795	110	52	-	-	ADJ
mkg-795	110	53	skp2	skp2	ADJ
mkg-795	110	54	s	s	NOUN
mkg-795	110	55	in	in	ADP
mkg-795	110	56	vivo	vivo	NOUN
mkg-795	110	57	animal	animal	NOUN
mkg-795	110	58	tumor	tumor	NOUN
mkg-795	110	59	model	model	NOUN
mkg-795	110	60	.	.	PUNCT
mkg-795	111	1	several	several	ADJ
mkg-795	111	2	investigators	investigator	NOUN
mkg-795	111	3	have	have	AUX
mkg-795	111	4	already	already	ADV
mkg-795	111	5	shown	show	VERB
mkg-795	111	6	a	a	DET
mkg-795	111	7	relationship	relationship	NOUN
mkg-795	111	8	between	between	ADP
mkg-795	111	9	expression	expression	NOUN
mkg-795	111	10	of	of	ADP
mkg-795	111	11	skp2	skp2	PROPN
mkg-795	111	12	and	and	CCONJ
mkg-795	111	13	apoptosis	apoptosis	VERB
mkg-795	111	14	.	.	PUNCT
mkg-795	112	1	s	s	NOUN
mkg-795	112	2	-	-	PUNCT
mkg-795	112	3	phase	phase	NOUN
mkg-795	112	4	induction	induction	NOUN
mkg-795	112	5	by	by	ADP
mkg-795	112	6	adenovirus	adenovirus	NOUN
mkg-795	112	7	-	-	PUNCT
mkg-795	112	8	vector	vector	NOUN
mkg-795	112	9	mediated	mediate	VERB
mkg-795	112	10	expression	expression	NOUN
mkg-795	112	11	of	of	ADP
mkg-795	112	12	skp2	skp2	PROPN
mkg-795	112	13	in	in	ADP
mkg-795	112	14	quiescent	quiescent	ADJ
mkg-795	112	15	cells	cell	NOUN
mkg-795	112	16	was	be	AUX
mkg-795	112	17	followed	follow	VERB
mkg-795	112	18	by	by	ADP
mkg-795	112	19	apoptosis.6	apoptosis.6	PROPN
mkg-795	112	20	mouse	mouse	NOUN
mkg-795	112	21	embryonic	embryonic	ADJ
mkg-795	112	22	fibroblast	fibroblast	ADJ
mkg-795	112	23	(	(	PUNCT
mkg-795	112	24	mef	mef	NOUN
mkg-795	112	25	)	)	PUNCT
mkg-795	112	26	in	in	ADP
mkg-795	112	27	skp2	skp2	ADJ
mkg-795	112	28	-	-	PUNCT
mkg-795	112	29	deficient	deficient	ADJ
mkg-795	112	30	mice	mouse	NOUN
mkg-795	112	31	showed	show	VERB
mkg-795	112	32	an	an	DET
mkg-795	112	33	increased	increased	ADJ
mkg-795	112	34	tendency	tendency	NOUN
mkg-795	112	35	toward	toward	ADP
mkg-795	112	36	spontaneous	spontaneous	ADJ
mkg-795	112	37	apoptosis.11	apoptosis.11	ADJ
mkg-795	112	38	antisense	antisense	NOUN
mkg-795	112	39	skp2	skp2	ADJ
mkg-795	112	40	and	and	CCONJ
mkg-795	112	41	jab1	jab1	ADV
mkg-795	112	42	induce	induce	VERB
mkg-795	112	43	apoptosis	apoptosis	NOUN
mkg-795	112	44	in	in	ADP
mkg-795	112	45	human	human	ADJ
mkg-795	112	46	oral	oral	ADJ
mkg-795	112	47	tongue	tongue	NOUN
mkg-795	112	48	cancer	cancer	NOUN
mkg-795	112	49	cells	cell	NOUN
mkg-795	112	50	through	through	ADP
mkg-795	112	51	induction	induction	NOUN
mkg-795	112	52	of	of	ADP
mkg-795	112	53	p27kip1	p27kip1	PROPN
mkg-795	112	54	protein.13	protein.13	PROPN
mkg-795	112	55	since	since	SCONJ
mkg-795	112	56	components	component	NOUN
mkg-795	112	57	of	of	ADP
mkg-795	112	58	apoptotic	apoptotic	ADJ
mkg-795	112	59	programs	program	NOUN
mkg-795	112	60	represent	represent	VERB
mkg-795	112	61	promising	promise	VERB
mkg-795	112	62	targets	target	NOUN
mkg-795	112	63	for	for	ADP
mkg-795	112	64	anticancer	anticancer	NOUN
mkg-795	112	65	therapy	therapy	NOUN
mkg-795	112	66	,	,	PUNCT
mkg-795	112	67	down	down	ADP
mkg-795	112	68	-	-	PUNCT
mkg-795	112	69	regulation	regulation	NOUN
mkg-795	112	70	of	of	ADP
mkg-795	112	71	skp2	skp2	ADJ
mkg-795	112	72	by	by	ADP
mkg-795	112	73	the	the	DET
mkg-795	112	74	antisense	antisense	NOUN
mkg-795	112	75	oligonucleotide	oligonucleotide	NOUN
mkg-795	112	76	approach	approach	NOUN
mkg-795	112	77	could	could	AUX
mkg-795	112	78	be	be	AUX
mkg-795	112	79	a	a	DET
mkg-795	112	80	useful	useful	ADJ
mkg-795	112	81	apoptosis	apoptosis	NOUN
mkg-795	112	82	-	-	PUNCT
mkg-795	112	83	modulating	modulate	VERB
mkg-795	112	84	strategy	strategy	NOUN
mkg-795	112	85	for	for	ADP
mkg-795	112	86	treatment	treatment	NOUN
mkg-795	112	87	of	of	ADP
mkg-795	112	88	human	human	ADJ
mkg-795	112	89	head	head	NOUN
mkg-795	112	90	and	and	CCONJ
mkg-795	112	91	neck	neck	NOUN
mkg-795	112	92	cancers	cancer	NOUN
mkg-795	112	93	including	include	VERB
mkg-795	112	94	human	human	ADJ
mkg-795	112	95	soft	soft	ADJ
mkg-795	112	96	palate	palate	ADJ
mkg-795	112	97	cancers	cancer	NOUN
mkg-795	112	98	.	.	PUNCT
mkg-795	113	1	in	in	ADP
mkg-795	113	2	conclusion	conclusion	NOUN
mkg-795	113	3	,	,	PUNCT
mkg-795	113	4	antisense	antisense	NOUN
mkg-795	113	5	oligonucleotide	oligonucleotide	NOUN
mkg-795	113	6	p45skp2	p45skp2	NOUN
mkg-795	113	7	has	have	VERB
mkg-795	113	8	a	a	DET
mkg-795	113	9	high	high	ADJ
mkg-795	113	10	antitumor	antitumor	NOUN
mkg-795	113	11	activity	activity	NOUN
mkg-795	113	12	in	in	ADP
mkg-795	113	13	human	human	ADJ
mkg-795	113	14	soft	soft	ADJ
mkg-795	113	15	palate	palate	NOUN
mkg-795	113	16	cancer	cancer	NOUN
mkg-795	113	17	,	,	PUNCT
mkg-795	113	18	targeting	target	VERB
mkg-795	113	19	this	this	DET
mkg-795	113	20	molecule	molecule	NOUN
mkg-795	113	21	could	could	AUX
mkg-795	113	22	represent	represent	VERB
mkg-795	113	23	a	a	DET
mkg-795	113	24	promising	promising	ADJ
mkg-795	113	25	new	new	ADJ
mkg-795	113	26	therapeutics	therapeutic	NOUN
mkg-795	113	27	approach	approach	NOUN
mkg-795	113	28	for	for	ADP
mkg-795	113	29	this	this	DET
mkg-795	113	30	type	type	NOUN
mkg-795	113	31	of	of	ADP
mkg-795	113	32	cancer	cancer	NOUN
mkg-795	113	33	.	.	PUNCT
mkg-795	114	1	acknowledgments	acknowledgment	NOUN
mkg-795	114	2	the	the	DET
mkg-795	114	3	author	author	NOUN
mkg-795	114	4	heart	heart	NOUN
mkg-795	114	5	fully	fully	ADV
mkg-795	114	6	thanks	thank	NOUN
mkg-795	114	7	and	and	CCONJ
mkg-795	114	8	appreciates	appreciate	VERB
mkg-795	114	9	prof	prof	PROPN
mkg-795	114	10	.	.	PUNCT
mkg-795	115	1	mitsunobu	mitsunobu	PROPN
mkg-795	115	2	sato	sato	PROPN
mkg-795	115	3	dds	dds	PROPN
mkg-795	115	4	.	.	PROPN
mkg-795	115	5	,	,	PUNCT
mkg-795	115	6	ph.d	ph.d	PROPN
mkg-795	115	7	;	;	PUNCT
mkg-795	115	8	dr	dr	PROPN
mkg-795	115	9	.	.	PROPN
mkg-795	115	10	koji	koji	PROPN
mkg-795	115	11	harada	harada	PROPN
mkg-795	115	12	,	,	PUNCT
mkg-795	115	13	dds	dds	PROPN
mkg-795	115	14	.	.	PROPN
mkg-795	115	15	,	,	PUNCT
mkg-795	115	16	ph.d	ph.d	PROPN
mkg-795	115	17	;	;	PUNCT
mkg-795	115	18	dr	dr	PROPN
mkg-795	115	19	.	.	PROPN
mkg-795	115	20	hamakawa	hamakawa	PROPN
mkg-795	115	21	dds	dds	PROPN
mkg-795	115	22	.	.	PROPN
mkg-795	115	23	,	,	PUNCT
mkg-795	115	24	ph.d	ph.d	PROPN
mkg-795	115	25	and	and	CCONJ
mkg-795	115	26	teams	team	NOUN
mkg-795	115	27	,	,	PUNCT
mkg-795	115	28	department	department	NOUN
mkg-795	115	29	of	of	ADP
mkg-795	115	30	oral	oral	ADJ
mkg-795	115	31	maxillofacial	maxillofacial	ADJ
mkg-795	115	32	surgery	surgery	NOUN
mkg-795	115	33	and	and	CCONJ
mkg-795	115	34	oncology	oncology	NOUN
mkg-795	115	35	,	,	PUNCT
mkg-795	115	36	school	school	NOUN
mkg-795	115	37	of	of	ADP
mkg-795	115	38	dentistry	dentistry	NOUN
mkg-795	115	39	,	,	PUNCT
mkg-795	115	40	tokushima	tokushima	PROPN
mkg-795	115	41	university	university	PROPN
mkg-795	115	42	,	,	PUNCT
mkg-795	115	43	japan	japan	PROPN
mkg-795	115	44	,	,	PUNCT
mkg-795	115	45	for	for	ADP
mkg-795	115	46	providing	provide	VERB
mkg-795	115	47	some	some	DET
mkg-795	115	48	materials	material	NOUN
mkg-795	115	49	and	and	CCONJ
mkg-795	115	50	discussion	discussion	NOUN
mkg-795	115	51	.	.	PUNCT
mkg-795	116	1	references	reference	NOUN
mkg-795	116	2	1	1	NUM
mkg-795	116	3	.	.	PUNCT
mkg-795	116	4	cohan	cohan	PROPN
mkg-795	116	5	dm	dm	PROPN
mkg-795	116	6	,	,	PUNCT
mkg-795	116	7	popat	popat	NOUN
mkg-795	116	8	s	s	PROPN
mkg-795	116	9	,	,	PUNCT
mkg-795	116	10	kaplan	kaplan	PROPN
mkg-795	116	11	se	se	X
mkg-795	116	12	,	,	PUNCT
mkg-795	116	13	rigual	rigual	ADJ
mkg-795	116	14	n	n	CCONJ
mkg-795	116	15	,	,	PUNCT
mkg-795	116	16	loree	loree	PROPN
mkg-795	116	17	t	t	PROPN
mkg-795	116	18	,	,	PUNCT
mkg-795	116	19	hicks	hicks	PROPN
mkg-795	116	20	wl	wl	PROPN
mkg-795	116	21	jr	jr	PROPN
mkg-795	116	22	.	.	PROPN
mkg-795	116	23	oropharyngeal	oropharyngeal	ADJ
mkg-795	116	24	cancer	cancer	NOUN
mkg-795	116	25	:	:	PUNCT
mkg-795	116	26	current	current	ADJ
mkg-795	116	27	understanding	understanding	NOUN
mkg-795	116	28	and	and	CCONJ
mkg-795	116	29	management	management	NOUN
mkg-795	116	30	.	.	PUNCT
mkg-795	117	1	curr	curr	PROPN
mkg-795	117	2	opin	opin	NOUN
mkg-795	117	3	otolaryngol	otolaryngol	ADJ
mkg-795	117	4	head	head	NOUN
mkg-795	117	5	neck	neck	NOUN
mkg-795	117	6	surg	surg	NOUN
mkg-795	117	7	2009	2009	NUM
mkg-795	117	8	;	;	PUNCT
mkg-795	117	9	17(2	17(2	NUM
mkg-795	117	10	):	):	PUNCT
mkg-795	117	11	88–94	88–94	NOUN
mkg-795	117	12	.	.	NOUN
mkg-795	118	1	2	2	NUM
mkg-795	118	2	.	.	X
mkg-795	118	3	ammar	ammar	PROPN
mkg-795	118	4	a	a	PROPN
mkg-795	118	5	,	,	PUNCT
mkg-795	118	6	uchida	uchida	PROPN
mkg-795	118	7	d	d	PROPN
mkg-795	118	8	,	,	PUNCT
mkg-795	118	9	begum	begum	PROPN
mkg-795	118	10	nm	nm	PRON
mkg-795	118	11	,	,	PUNCT
mkg-795	118	12	tomizuka	tomizuka	PROPN
mkg-795	118	13	y	y	PROPN
mkg-795	118	14	,	,	PUNCT
mkg-795	118	15	iga	iga	PROPN
mkg-795	118	16	h	h	PROPN
mkg-795	118	17	,	,	PUNCT
mkg-795	118	18	yoshida	yoshida	PROPN
mkg-795	118	19	h	h	PROPN
mkg-795	118	20	,	,	PUNCT
mkg-795	118	21	sato	sato	NOUN
mkg-795	118	22	m.	m.	NOUN
mkg-795	118	23	the	the	DET
mkg-795	118	24	clinicopathological	clinicopathological	ADJ
mkg-795	118	25	significance	significance	NOUN
mkg-795	118	26	of	of	ADP
mkg-795	118	27	the	the	DET
mkg-795	118	28	expression	expression	NOUN
mkg-795	118	29	of	of	ADP
mkg-795	118	30	cxcr4	cxcr4	NOUN
mkg-795	118	31	protein	protein	NOUN
mkg-795	118	32	in	in	ADP
mkg-795	118	33	oral	oral	ADJ
mkg-795	118	34	squamous	squamous	ADJ
mkg-795	118	35	cell	cell	NOUN
mkg-795	118	36	carcinoma	carcinoma	NOUN
mkg-795	118	37	.	.	PUNCT
mkg-795	119	1	int	int	NOUN
mkg-795	119	2	j	j	PROPN
mkg-795	119	3	oncol	oncol	ADJ
mkg-795	119	4	2004	2004	NUM
mkg-795	119	5	;	;	PUNCT
mkg-795	119	6	25(1	25(1	NUM
mkg-795	119	7	):	):	PUNCT
mkg-795	119	8	65–71	65–71	NOUN
mkg-795	119	9	.	.	PUNCT
mkg-795	120	1	3	3	X
mkg-795	120	2	.	.	NOUN
mkg-795	120	3	inagi	inagi	PROPN
mkg-795	120	4	k	k	PROPN
mkg-795	120	5	,	,	PUNCT
mkg-795	120	6	takahashi	takahashi	PROPN
mkg-795	120	7	h	h	PROPN
mkg-795	120	8	,	,	PUNCT
mkg-795	120	9	okamoto	okamoto	PROPN
mkg-795	120	10	m	m	PROPN
mkg-795	120	11	,	,	PUNCT
mkg-795	120	12	nakayama	nakayama	PROPN
mkg-795	120	13	m	m	PROPN
mkg-795	120	14	,	,	PUNCT
mkg-795	120	15	makoshi	makoshi	PROPN
mkg-795	120	16	t	t	PROPN
mkg-795	120	17	,	,	PUNCT
mkg-795	120	18	nagai	nagai	PROPN
mkg-795	120	19	h.	h.	PROPN
mkg-795	120	20	treatment	treatment	NOUN
mkg-795	120	21	effects	effect	NOUN
mkg-795	120	22	in	in	ADP
mkg-795	120	23	patients	patient	NOUN
mkg-795	120	24	with	with	ADP
mkg-795	120	25	squamous	squamous	ADJ
mkg-795	120	26	cell	cell	NOUN
mkg-795	120	27	carcinoma	carcinoma	NOUN
mkg-795	120	28	of	of	ADP
mkg-795	120	29	the	the	DET
mkg-795	120	30	oral	oral	ADJ
mkg-795	120	31	cavity	cavity	NOUN
mkg-795	120	32	.	.	PUNCT
mkg-795	121	1	acta	acta	PROPN
mkg-795	121	2	otolaryngol	otolaryngol	PROPN
mkg-795	121	3	suppl	suppl	PROPN
mkg-795	121	4	2002	2002	NUM
mkg-795	121	5	;	;	PUNCT
mkg-795	121	6	547	547	NUM
mkg-795	121	7	:	:	PUNCT
mkg-795	122	1	25–9	25–9	NUM
mkg-795	122	2	.	.	NOUN
mkg-795	122	3	4	4	NUM
mkg-795	122	4	.	.	X
mkg-795	122	5	bray	bray	PROPN
mkg-795	122	6	f	f	PROPN
mkg-795	122	7	,	,	PUNCT
mkg-795	122	8	sankila	sankila	ADJ
mkg-795	122	9	r	r	NOUN
mkg-795	122	10	,	,	PUNCT
mkg-795	122	11	ferlay	ferlay	NOUN
mkg-795	122	12	j	j	NOUN
mkg-795	122	13	,	,	PUNCT
mkg-795	122	14	parkin	parkin	ADJ
mkg-795	122	15	dm	dm	PROPN
mkg-795	122	16	.	.	PUNCT
mkg-795	122	17	estimates	estimate	NOUN
mkg-795	122	18	of	of	ADP
mkg-795	122	19	cancer	cancer	NOUN
mkg-795	122	20	incidence	incidence	NOUN
mkg-795	122	21	and	and	CCONJ
mkg-795	122	22	mortality	mortality	NOUN
mkg-795	122	23	in	in	ADP
mkg-795	122	24	europe	europe	PROPN
mkg-795	122	25	in	in	ADP
mkg-795	122	26	1995	1995	NUM
mkg-795	122	27	.	.	PUNCT
mkg-795	123	1	europ	europ	PROPN
mkg-795	123	2	j	j	PROPN
mkg-795	123	3	cancer	cancer	PROPN
mkg-795	123	4	2002	2002	NUM
mkg-795	123	5	;	;	PUNCT
mkg-795	123	6	38(1	38(1	NUM
mkg-795	123	7	):	):	PUNCT
mkg-795	123	8	99–166	99–166	PROPN
mkg-795	123	9	.	.	PUNCT
mkg-795	123	10	�	�	PROPN
mkg-795	123	11	�	�	PROPN
mkg-795	123	12	dent	dent	NOUN
mkg-795	123	13	.	.	PUNCT
mkg-795	124	1	j.	j.	PROPN
mkg-795	124	2	(	(	PUNCT
mkg-795	124	3	maj	maj	PROPN
mkg-795	124	4	.	.	PROPN
mkg-795	124	5	ked	ked	PROPN
mkg-795	124	6	.	.	PUNCT
mkg-795	125	1	gigi	gigi	PROPN
mkg-795	125	2	)	)	PUNCT
mkg-795	126	1	,	,	PUNCT
mkg-795	126	2	volume	volume	NOUN
mkg-795	126	3	46	46	NUM
mkg-795	126	4	number	number	NOUN
mkg-795	126	5	1	1	NUM
mkg-795	126	6	march	march	NOUN
mkg-795	126	7	2013	2013	NUM
mkg-795	126	8	:	:	PUNCT
mkg-795	126	9	18–22	18–22	NUM
mkg-795	126	10	5	5	NUM
mkg-795	126	11	.	.	PUNCT
mkg-795	127	1	wu	wu	PROPN
mkg-795	127	2	l	l	PROPN
mkg-795	127	3	,	,	PUNCT
mkg-795	127	4	grigoryan	grigoryan	PROPN
mkg-795	127	5	av	av	PROPN
mkg-795	127	6	,	,	PUNCT
mkg-795	127	7	li	li	PROPN
mkg-795	127	8	y	y	PROPN
mkg-795	127	9	,	,	PUNCT
mkg-795	127	10	hao	hao	PROPN
mkg-795	127	11	b	b	PROPN
mkg-795	127	12	,	,	PUNCT
mkg-795	127	13	pagano	pagano	PROPN
mkg-795	127	14	m	m	PROPN
mkg-795	127	15	,	,	PUNCT
mkg-795	127	16	cardozo	cardozo	PROPN
mkg-795	127	17	tj	tj	PROPN
mkg-795	127	18	.	.	PROPN
mkg-795	127	19	specific	specific	ADJ
mkg-795	127	20	small	small	ADJ
mkg-795	127	21	molecule	molecule	NOUN
mkg-795	127	22	inhibitors	inhibitor	NOUN
mkg-795	127	23	of	of	ADP
mkg-795	127	24	skp2	skp2	ADV
mkg-795	127	25	-	-	PUNCT
mkg-795	127	26	mediated	mediate	VERB
mkg-795	127	27	p27	p27	NOUN
mkg-795	127	28	degradation	degradation	NOUN
mkg-795	127	29	.	.	PUNCT
mkg-795	128	1	chemi	chemi	PROPN
mkg-795	128	2	biol	biol	PROPN
mkg-795	128	3	2012	2012	NUM
mkg-795	128	4	;	;	PUNCT
mkg-795	128	5	19(12	19(12	NUM
mkg-795	128	6	):	):	PUNCT
mkg-795	128	7	1515–24	1515–24	NUM
mkg-795	128	8	.	.	PUNCT
mkg-795	129	1	6	6	NUM
mkg-795	129	2	.	.	X
mkg-795	129	3	zheng	zheng	PROPN
mkg-795	129	4	wq	wq	PROPN
mkg-795	129	5	,	,	PUNCT
mkg-795	129	6	zheng	zheng	PROPN
mkg-795	129	7	jm	jm	PROPN
mkg-795	129	8	,	,	PUNCT
mkg-795	129	9	ma	ma	PROPN
mkg-795	129	10	r	r	PROPN
mkg-795	129	11	,	,	PUNCT
mkg-795	129	12	meng	meng	PROPN
mkg-795	129	13	ff	ff	PROPN
mkg-795	129	14	,	,	PUNCT
mkg-795	129	15	ni	ni	PROPN
mkg-795	129	16	cr	cr	PROPN
mkg-795	129	17	.	.	PROPN
mkg-795	129	18	relationship	relationship	NOUN
mkg-795	129	19	between	between	ADP
mkg-795	129	20	levels	level	NOUN
mkg-795	129	21	of	of	ADP
mkg-795	129	22	skp2	skp2	PROPN
mkg-795	129	23	and	and	CCONJ
mkg-795	129	24	p27	p27	NOUN
mkg-795	129	25	in	in	ADP
mkg-795	129	26	breast	breast	NOUN
mkg-795	129	27	carcinomas	carcinoma	NOUN
mkg-795	129	28	and	and	CCONJ
mkg-795	129	29	possible	possible	ADJ
mkg-795	129	30	role	role	NOUN
mkg-795	129	31	of	of	ADP
mkg-795	129	32	skp2	skp2	PROPN
mkg-795	129	33	as	as	ADP
mkg-795	129	34	a	a	DET
mkg-795	129	35	target	target	NOUN
mkg-795	129	36	therapy	therapy	NOUN
mkg-795	129	37	.	.	PUNCT
mkg-795	130	1	steroids	steroid	NOUN
mkg-795	130	2	2005	2005	NUM
mkg-795	130	3	;	;	PUNCT
mkg-795	130	4	70(11	70(11	NUM
mkg-795	130	5	):	):	PUNCT
mkg-795	130	6	770–4	770–4	NOUN
mkg-795	130	7	.	.	NOUN
mkg-795	131	1	7	7	X
mkg-795	131	2	.	.	NUM
mkg-795	131	3	hershko	hershko	PROPN
mkg-795	131	4	d	d	PROPN
mkg-795	131	5	,	,	PUNCT
mkg-795	131	6	bornstein	bornstein	NOUN
mkg-795	131	7	g	g	PROPN
mkg-795	131	8	,	,	PUNCT
mkg-795	131	9	ben	ben	PROPN
mkg-795	131	10	-	-	ADJ
mkg-795	131	11	izhak	izhak	PROPN
mkg-795	131	12	o	o	NOUN
mkg-795	131	13	,	,	PUNCT
mkg-795	131	14	carrano	carrano	PROPN
mkg-795	131	15	a	a	X
mkg-795	131	16	,	,	PUNCT
mkg-795	131	17	pagano	pagano	PROPN
mkg-795	131	18	m	m	PROPN
mkg-795	131	19	,	,	PUNCT
mkg-795	131	20	krausz	krausz	PROPN
mkg-795	131	21	mm	mm	PROPN
mkg-795	131	22	,	,	PUNCT
mkg-795	131	23	hershko	hershko	ADJ
mkg-795	131	24	a.	a.	NOUN
mkg-795	131	25	inverse	inverse	NOUN
mkg-795	131	26	relation	relation	NOUN
mkg-795	131	27	between	between	ADP
mkg-795	131	28	levels	level	NOUN
mkg-795	131	29	of	of	ADP
mkg-795	131	30	p27kip1	p27kip1	PROPN
mkg-795	131	31	and	and	CCONJ
mkg-795	131	32	of	of	ADP
mkg-795	131	33	its	its	PRON
mkg-795	131	34	ubiquitin	ubiquitin	ADJ
mkg-795	131	35	ligase	ligase	NOUN
mkg-795	131	36	subunit	subunit	NOUN
mkg-795	131	37	skp2	skp2	VERB
mkg-795	131	38	in	in	ADP
mkg-795	131	39	colorectal	colorectal	ADJ
mkg-795	131	40	carcinoma	carcinoma	NOUN
mkg-795	131	41	.	.	PUNCT
mkg-795	132	1	cancer	cancer	NOUN
mkg-795	132	2	2001	2001	NUM
mkg-795	132	3	;	;	PUNCT
mkg-795	132	4	91(9	91(9	NUM
mkg-795	132	5	):	):	PUNCT
mkg-795	132	6	1745–51	1745–51	NUM
mkg-795	132	7	.	.	PUNCT
mkg-795	132	8	8	8	X
mkg-795	132	9	.	.	PUNCT
mkg-795	133	1	chiarle	chiarle	PROPN
mkg-795	133	2	r	r	PROPN
mkg-795	133	3	,	,	PUNCT
mkg-795	133	4	fan	fan	PROPN
mkg-795	133	5	y	y	PROPN
mkg-795	133	6	,	,	PUNCT
mkg-795	133	7	piva	piva	PROPN
mkg-795	133	8	r	r	PROPN
mkg-795	133	9	,	,	PUNCT
mkg-795	133	10	boggino	boggino	NOUN
mkg-795	133	11	h	h	NOUN
mkg-795	133	12	,	,	PUNCT
mkg-795	133	13	skolnik	skolnik	PROPN
mkg-795	133	14	j	j	PROPN
mkg-795	133	15	,	,	PUNCT
mkg-795	133	16	novero	novero	PROPN
mkg-795	133	17	d	d	PROPN
mkg-795	133	18	,	,	PUNCT
mkg-795	133	19	palestro	palestro	NOUN
mkg-795	133	20	g	g	NOUN
mkg-795	133	21	,	,	PUNCT
mkg-795	133	22	de	de	X
mkg-795	133	23	wolf	wolf	NOUN
mkg-795	133	24	-	-	PUNCT
mkg-795	133	25	peeters	peeter	NOUN
mkg-795	133	26	c	c	NOUN
mkg-795	133	27	,	,	PUNCT
mkg-795	133	28	chilosi	chilosi	PROPN
mkg-795	133	29	m	m	PROPN
mkg-795	133	30	,	,	PUNCT
mkg-795	133	31	pagano	pagano	PROPN
mkg-795	133	32	m	m	PROPN
mkg-795	133	33	,	,	PUNCT
mkg-795	133	34	inghirami	inghirami	NOUN
mkg-795	133	35	g.	g.	PROPN
mkg-795	133	36	s	s	NOUN
mkg-795	133	37	-	-	PUNCT
mkg-795	133	38	phase	phase	NOUN
mkg-795	133	39	kinase	kinase	NOUN
mkg-795	133	40	-	-	PUNCT
mkg-795	133	41	associated	associate	VERB
mkg-795	133	42	protein	protein	NOUN
mkg-795	133	43	2	2	NUM
mkg-795	133	44	expression	expression	NOUN
mkg-795	133	45	in	in	ADP
mkg-795	133	46	non	non	ADJ
mkg-795	133	47	-	-	ADJ
mkg-795	133	48	hodgkin	hodgkin	ADJ
mkg-795	133	49	’s	’s	PART
mkg-795	133	50	lymphoma	lymphoma	NOUN
mkg-795	133	51	inversely	inversely	ADV
mkg-795	133	52	correlates	correlate	VERB
mkg-795	133	53	with	with	ADP
mkg-795	133	54	p27	p27	NOUN
mkg-795	133	55	expression	expression	NOUN
mkg-795	133	56	and	and	CCONJ
mkg-795	133	57	defines	define	VERB
mkg-795	133	58	cells	cell	NOUN
mkg-795	133	59	in	in	ADP
mkg-795	133	60	s	s	NOUN
mkg-795	133	61	phase	phase	NOUN
mkg-795	133	62	.	.	PUNCT
mkg-795	134	1	am	be	AUX
mkg-795	134	2	j	j	PROPN
mkg-795	134	3	pathol	pathol	NOUN
mkg-795	134	4	2002	2002	NUM
mkg-795	134	5	;	;	PUNCT
mkg-795	134	6	160(4	160(4	NUM
mkg-795	134	7	):	):	PUNCT
mkg-795	134	8	1457–66	1457–66	NOUN
mkg-795	134	9	.	.	PUNCT
mkg-795	135	1	9	9	X
mkg-795	135	2	.	.	X
mkg-795	135	3	masuda	masuda	PROPN
mkg-795	135	4	ta	ta	PROPN
mkg-795	135	5	,	,	PUNCT
mkg-795	135	6	inoue	inoue	PROPN
mkg-795	135	7	h	h	PROPN
mkg-795	135	8	,	,	PUNCT
mkg-795	135	9	sonoda	sonoda	ADJ
mkg-795	135	10	h	h	NOUN
mkg-795	135	11	,	,	PUNCT
mkg-795	135	12	mine	mine	PRON
mkg-795	135	13	s	s	PROPN
mkg-795	135	14	,	,	PUNCT
mkg-795	135	15	yoshikawa	yoshikawa	PROPN
mkg-795	135	16	y	y	PROPN
mkg-795	135	17	,	,	PUNCT
mkg-795	135	18	nakayama	nakayama	PROPN
mkg-795	135	19	k	k	PROPN
mkg-795	135	20	,	,	PUNCT
mkg-795	135	21	mori	mori	NOUN
mkg-795	135	22	m.	m.	NOUN
mkg-795	135	23	clinical	clinical	ADJ
mkg-795	135	24	and	and	CCONJ
mkg-795	135	25	biological	biological	ADJ
mkg-795	135	26	significance	significance	NOUN
mkg-795	135	27	of	of	ADP
mkg-795	135	28	s	s	NOUN
mkg-795	135	29	-	-	PUNCT
mkg-795	135	30	phase	phase	NOUN
mkg-795	135	31	kinaseassociated	kinaseassociate	VERB
mkg-795	135	32	protein	protein	NOUN
mkg-795	135	33	2	2	NUM
mkg-795	135	34	(	(	PUNCT
mkg-795	135	35	skp2	skp2	ADJ
mkg-795	135	36	)	)	PUNCT
mkg-795	135	37	gene	gene	NOUN
mkg-795	135	38	expression	expression	NOUN
mkg-795	135	39	in	in	ADP
mkg-795	135	40	gastric	gastric	ADJ
mkg-795	135	41	carcinoma	carcinoma	NOUN
mkg-795	135	42	:	:	PUNCT
mkg-795	135	43	modulation	modulation	NOUN
mkg-795	135	44	of	of	ADP
mkg-795	135	45	malignant	malignant	ADJ
mkg-795	135	46	phenotype	phenotype	NOUN
mkg-795	135	47	by	by	ADP
mkg-795	135	48	skp2	skp2	ADJ
mkg-795	135	49	overexpression	overexpression	NOUN
mkg-795	135	50	,	,	PUNCT
mkg-795	135	51	possibly	possibly	ADV
mkg-795	135	52	via	via	ADP
mkg-795	135	53	p27	p27	NOUN
mkg-795	135	54	proteolysis	proteolysis	NOUN
mkg-795	135	55	.	.	PUNCT
mkg-795	136	1	cancer	cancer	NOUN
mkg-795	136	2	res	re	NOUN
mkg-795	136	3	.	.	PUNCT
mkg-795	136	4	2002	2002	NUM
mkg-795	136	5	;	;	PUNCT
mkg-795	136	6	62	62	NUM
mkg-795	136	7	:	:	PUNCT
mkg-795	136	8	3819–25	3819–25	NUM
mkg-795	136	9	.	.	PUNCT
mkg-795	137	1	10	10	NUM
mkg-795	137	2	.	.	PUNCT
mkg-795	138	1	yokoi	yokoi	PROPN
mkg-795	138	2	s	s	PROPN
mkg-795	138	3	,	,	PUNCT
mkg-795	138	4	yasui	yasui	PROPN
mkg-795	138	5	k	k	PROPN
mkg-795	138	6	,	,	PUNCT
mkg-795	138	7	lizasa	lizasa	PROPN
mkg-795	138	8	t	t	PROPN
mkg-795	138	9	,	,	PUNCT
mkg-795	138	10	takahashi	takahashi	PROPN
mkg-795	138	11	t	t	PROPN
mkg-795	138	12	,	,	PUNCT
mkg-795	138	13	fujisawa	fujisawa	PROPN
mkg-795	138	14	t	t	PROPN
mkg-795	138	15	,	,	PUNCT
mkg-795	138	16	inazawa	inazawa	PROPN
mkg-795	138	17	j.	j.	PROPN
mkg-795	138	18	down	down	PROPN
mkg-795	138	19	-	-	PUNCT
mkg-795	138	20	regulation	regulation	NOUN
mkg-795	138	21	of	of	ADP
mkg-795	138	22	skp2	skp2	PROPN
mkg-795	138	23	induces	induce	NOUN
mkg-795	138	24	apoptosis	apoptosis	NOUN
mkg-795	138	25	in	in	ADP
mkg-795	138	26	lung	lung	NOUN
mkg-795	138	27	-	-	PUNCT
mkg-795	138	28	cancer	cancer	NOUN
mkg-795	138	29	cells	cell	NOUN
mkg-795	138	30	.	.	PUNCT
mkg-795	139	1	cancer	cancer	NOUN
mkg-795	139	2	sci	sci	PROPN
mkg-795	139	3	2003	2003	NUM
mkg-795	139	4	;	;	PUNCT
mkg-795	139	5	94(4	94(4	NUM
mkg-795	139	6	):	):	PUNCT
mkg-795	139	7	344–9	344–9	NUM
mkg-795	139	8	.	.	PUNCT
mkg-795	140	1	11	11	NUM
mkg-795	140	2	.	.	X
mkg-795	141	1	nakayama	nakayama	PROPN
mkg-795	141	2	k	k	PROPN
mkg-795	141	3	,	,	PUNCT
mkg-795	141	4	nagahama	nagahama	NOUN
mkg-795	141	5	h	h	NOUN
mkg-795	141	6	,	,	PUNCT
mkg-795	141	7	minamishima	minamishima	PROPN
mkg-795	141	8	ya	ya	PROPN
mkg-795	141	9	,	,	PUNCT
mkg-795	141	10	matsumoto	matsumoto	PROPN
mkg-795	141	11	m	m	PROPN
mkg-795	141	12	,	,	PUNCT
mkg-795	141	13	nakamichi	nakamichi	PROPN
mkg-795	141	14	i	i	PROPN
mkg-795	141	15	,	,	PUNCT
mkg-795	141	16	kitagawa	kitagawa	PROPN
mkg-795	141	17	k.	k.	PROPN
mkg-795	141	18	targeted	target	VERB
mkg-795	141	19	disruption	disruption	NOUN
mkg-795	141	20	of	of	ADP
mkg-795	141	21	skp2	skp2	ADJ
mkg-795	141	22	results	result	NOUN
mkg-795	141	23	in	in	ADP
mkg-795	141	24	accumulation	accumulation	NOUN
mkg-795	141	25	of	of	ADP
mkg-795	141	26	cyclin	cyclin	NOUN
mkg-795	141	27	e	e	PROPN
mkg-795	141	28	and	and	CCONJ
mkg-795	141	29	p27kip1	p27kip1	PROPN
mkg-795	141	30	,	,	PUNCT
mkg-795	141	31	polyploidy	polyploidy	ADJ
mkg-795	141	32	and	and	CCONJ
mkg-795	141	33	centrosome	centrosome	PROPN
mkg-795	141	34	overduplication	overduplication	NOUN
mkg-795	141	35	.	.	PUNCT
mkg-795	142	1	embo	embo	PROPN
mkg-795	142	2	j	j	PROPN
mkg-795	142	3	2000	2000	NUM
mkg-795	142	4	;	;	PUNCT
mkg-795	142	5	19(9	19(9	NUM
mkg-795	142	6	):	):	PUNCT
mkg-795	142	7	2069–81	2069–81	NUM
mkg-795	142	8	.	.	PUNCT
mkg-795	143	1	12	12	NUM
mkg-795	143	2	.	.	PUNCT
mkg-795	144	1	supriatno	supriatno	PROPN
mkg-795	144	2	.	.	PUNCT
mkg-795	145	1	oligonukleotid	oligonukleotid	NOUN
mkg-795	145	2	s	s	NOUN
mkg-795	145	3	-	-	PUNCT
mkg-795	145	4	phase	phase	NOUN
mkg-795	145	5	kinase	kinase	PROPN
mkg-795	145	6	associated	associated	PROPN
mkg-795	145	7	protein-2	protein-2	PROPN
mkg-795	145	8	(	(	PUNCT
mkg-795	145	9	skp2	skp2	ADJ
mkg-795	145	10	)	)	PUNCT
mkg-795	145	11	antisense	antisense	NOUN
mkg-795	145	12	induces	induce	VERB
mkg-795	145	13	the	the	DET
mkg-795	145	14	growth	growth	NOUN
mkg-795	145	15	inhibition	inhibition	NOUN
mkg-795	145	16	and	and	CCONJ
mkg-795	145	17	increases	increase	VERB
mkg-795	145	18	apoptosis	apoptosis	NOUN
mkg-795	145	19	activity	activity	NOUN
mkg-795	145	20	on	on	ADP
mkg-795	145	21	head	head	NOUN
mkg-795	145	22	and	and	CCONJ
mkg-795	145	23	neck	neck	NOUN
mkg-795	145	24	cancer	cancer	NOUN
mkg-795	145	25	cell	cell	NOUN
mkg-795	145	26	lines	line	NOUN
mkg-795	145	27	.	.	PUNCT
mkg-795	146	1	proceeding	proceed	VERB
mkg-795	146	2	gadjah	gadjah	PROPN
mkg-795	146	3	mada	mada	PROPN
mkg-795	146	4	university	university	PROPN
mkg-795	146	5	of	of	ADP
mkg-795	146	6	inter	inter	ADJ
mkg-795	146	7	-	-	ADJ
mkg-795	146	8	cluster	cluster	ADJ
mkg-795	146	9	research	research	NOUN
mkg-795	146	10	.	.	PUNCT
mkg-795	147	1	57th	57th	ADJ
mkg-795	147	2	dies	die	VERB
mkg-795	147	3	natalis	natalis	ADV
mkg-795	147	4	gmu	gmu	PROPN
mkg-795	147	5	,	,	PUNCT
mkg-795	147	6	november	november	PROPN
mkg-795	147	7	28	28	NUM
mkg-795	147	8	,	,	PUNCT
mkg-795	147	9	yogyakarta	yogyakarta	PROPN
mkg-795	147	10	;	;	PUNCT
mkg-795	147	11	2006	2006	NUM
mkg-795	147	12	.	.	PUNCT
mkg-795	148	1	p.	p.	NOUN
mkg-795	148	2	1–13	1–13	PROPN
mkg-795	148	3	.	.	PUNCT
mkg-795	149	1	13	13	NUM
mkg-795	149	2	.	.	X
mkg-795	150	1	supriatno	supriatno	PROPN
mkg-795	150	2	,	,	PUNCT
mkg-795	150	3	harada	harada	PROPN
mkg-795	150	4	k	k	PROPN
mkg-795	150	5	,	,	PUNCT
mkg-795	150	6	yoshida	yoshida	PROPN
mkg-795	150	7	h	h	PROPN
mkg-795	150	8	,	,	PUNCT
mkg-795	150	9	sato	sato	PROPN
mkg-795	150	10	m.	m.	NOUN
mkg-795	150	11	basic	basic	ADJ
mkg-795	150	12	investigation	investigation	NOUN
mkg-795	150	13	on	on	ADP
mkg-795	150	14	the	the	DET
mkg-795	150	15	development	development	NOUN
mkg-795	150	16	of	of	ADP
mkg-795	150	17	molecular	molecular	ADJ
mkg-795	150	18	targeting	targeting	NOUN
mkg-795	150	19	therapy	therapy	NOUN
mkg-795	150	20	against	against	ADP
mkg-795	150	21	cyclin	cyclin	NOUN
mkg-795	150	22	-	-	PUNCT
mkg-795	150	23	dependent	dependent	ADJ
mkg-795	150	24	kinase	kinase	NOUN
mkg-795	150	25	inhibitor	inhibitor	NOUN
mkg-795	150	26	p27kip1	p27kip1	PROPN
mkg-795	150	27	in	in	ADP
mkg-795	150	28	head	head	NOUN
mkg-795	150	29	and	and	CCONJ
mkg-795	150	30	neck	neck	NOUN
mkg-795	150	31	cancer	cancer	NOUN
mkg-795	150	32	cells	cell	NOUN
mkg-795	150	33	.	.	PUNCT
mkg-795	151	1	int	int	NOUN
mkg-795	151	2	j	j	PROPN
mkg-795	151	3	oncol	oncol	ADJ
mkg-795	151	4	2005	2005	NUM
mkg-795	151	5	;	;	PUNCT
mkg-795	151	6	27(3	27(3	NUM
mkg-795	151	7	):	):	PUNCT
mkg-795	151	8	627–35	627–35	NUM
mkg-795	151	9	.	.	PUNCT
mkg-795	152	1	14	14	NUM
mkg-795	152	2	.	.	PUNCT
mkg-795	152	3	wacheck	wacheck	PROPN
mkg-795	152	4	v	v	PROPN
mkg-795	152	5	,	,	PUNCT
mkg-795	152	6	weiss	weiss	PROPN
mkg-795	152	7	ujw	ujw	PROPN
mkg-795	152	8	.	.	PUNCT
mkg-795	153	1	antisense	antisense	NOUN
mkg-795	153	2	molecules	molecule	NOUN
mkg-795	153	3	for	for	ADP
mkg-795	153	4	targeted	target	VERB
mkg-795	153	5	cancer	cancer	NOUN
mkg-795	153	6	therapy	therapy	NOUN
mkg-795	153	7	.	.	PUNCT
mkg-795	154	1	crit	crit	PROPN
mkg-795	154	2	rev	rev	PROPN
mkg-795	154	3	oncol	oncol	ADJ
mkg-795	154	4	hematol	hematol	NOUN
mkg-795	154	5	2006	2006	NUM
mkg-795	154	6	;	;	PUNCT
mkg-795	154	7	59(1	59(1	NUM
mkg-795	154	8	):	):	PUNCT
mkg-795	154	9	65–73	65–73	NUM
mkg-795	154	10	.	.	PUNCT
mkg-795	155	1	15	15	NUM
mkg-795	155	2	.	.	X
mkg-795	155	3	pastorino	pastorino	PROPN
mkg-795	155	4	f	f	PROPN
mkg-795	155	5	,	,	PUNCT
mkg-795	155	6	stuart	stuart	PROPN
mkg-795	155	7	d	d	PROPN
mkg-795	155	8	,	,	PUNCT
mkg-795	155	9	ponzoni	ponzoni	PROPN
mkg-795	155	10	m	m	PROPN
mkg-795	155	11	,	,	PUNCT
mkg-795	155	12	allen	allen	PROPN
mkg-795	155	13	tm	tm	PROPN
mkg-795	155	14	.	.	PROPN
mkg-795	155	15	targeted	target	VERB
mkg-795	155	16	delivery	delivery	NOUN
mkg-795	155	17	of	of	ADP
mkg-795	155	18	antisense	antisense	NOUN
mkg-795	155	19	oligonucleotides	oligonucleotide	NOUN
mkg-795	155	20	in	in	ADP
mkg-795	155	21	cancer	cancer	NOUN
mkg-795	155	22	.	.	PUNCT
mkg-795	156	1	j	j	PROPN
mkg-795	156	2	contr	contr	VERB
mkg-795	156	3	rel	rel	NOUN
mkg-795	156	4	2001	2001	NUM
mkg-795	156	5	;	;	PUNCT
mkg-795	156	6	74(1	74(1	NOUN
mkg-795	156	7	):	):	PUNCT
mkg-795	156	8	69–75	69–75	NUM
mkg-795	156	9	.	.	PUNCT
mkg-795	157	1	16	16	NUM
mkg-795	157	2	.	.	PUNCT
mkg-795	158	1	azuma	azuma	PROPN
mkg-795	158	2	m	m	PROPN
mkg-795	158	3	,	,	PUNCT
mkg-795	158	4	harada	harada	PROPN
mkg-795	158	5	k	k	PROPN
mkg-795	158	6	,	,	PUNCT
mkg-795	158	7	supriatno	supriatno	PROPN
mkg-795	158	8	,	,	PUNCT
mkg-795	158	9	tamatani	tamatani	PROPN
mkg-795	158	10	t	t	PROPN
mkg-795	158	11	,	,	PUNCT
mkg-795	158	12	motegi	motegi	PROPN
mkg-795	158	13	k	k	PROPN
mkg-795	158	14	,	,	PUNCT
mkg-795	158	15	ashida	ashida	PROPN
mkg-795	158	16	y	y	PROPN
mkg-795	158	17	,	,	PUNCT
mkg-795	158	18	sato	sato	NOUN
mkg-795	158	19	m.	m.	NOUN
mkg-795	158	20	potentiation	potentiation	NOUN
mkg-795	158	21	of	of	ADP
mkg-795	158	22	induction	induction	NOUN
mkg-795	158	23	of	of	ADP
mkg-795	158	24	apoptosis	apoptosis	NOUN
mkg-795	158	25	by	by	ADP
mkg-795	158	26	sequential	sequential	ADJ
mkg-795	158	27	treatment	treatment	NOUN
mkg-795	158	28	with	with	ADP
mkg-795	158	29	cisplatin	cisplatin	NOUN
mkg-795	158	30	followed	follow	VERB
mkg-795	158	31	by	by	ADP
mkg-795	158	32	5	5	NUM
mkg-795	158	33	-	-	PUNCT
mkg-795	158	34	fluorouracil	fluorouracil	NOUN
mkg-795	158	35	in	in	ADP
mkg-795	158	36	human	human	ADJ
mkg-795	158	37	oral	oral	ADJ
mkg-795	158	38	cancer	cancer	NOUN
mkg-795	158	39	cells	cell	NOUN
mkg-795	158	40	.	.	PUNCT
mkg-795	159	1	int	int	NOUN
mkg-795	159	2	j	j	PROPN
mkg-795	159	3	oncol	oncol	ADJ
mkg-795	159	4	2004	2004	NUM
mkg-795	159	5	;	;	PUNCT
mkg-795	159	6	24(6	24(6	NUM
mkg-795	159	7	):	):	PUNCT
mkg-795	159	8	1449–55	1449–55	NOUN
mkg-795	159	9	.	.	PUNCT
mkg-795	160	1	17	17	NUM
mkg-795	160	2	.	.	PUNCT
mkg-795	160	3	qiao	qiao	PROPN
mkg-795	160	4	l	l	PROPN
mkg-795	160	5	,	,	PUNCT
mkg-795	160	6	wong	wong	PROPN
mkg-795	160	7	bcw	bcw	PROPN
mkg-795	160	8	.	.	PUNCT
mkg-795	160	9	targeting	target	VERB
mkg-795	160	10	apoptosis	apoptosis	NOUN
mkg-795	160	11	as	as	ADP
mkg-795	160	12	an	an	DET
mkg-795	160	13	approach	approach	NOUN
mkg-795	160	14	for	for	ADP
mkg-795	160	15	gastrointestinal	gastrointestinal	ADJ
mkg-795	160	16	cancer	cancer	NOUN
mkg-795	160	17	therapy	therapy	NOUN
mkg-795	160	18	.	.	PUNCT
mkg-795	161	1	drug	drug	NOUN
mkg-795	161	2	resist	resist	VERB
mkg-795	161	3	2009	2009	NUM
mkg-795	161	4	;	;	PUNCT
mkg-795	161	5	12(3	12(3	NUM
mkg-795	161	6	):	):	PUNCT
mkg-795	161	7	55–64	55–64	NUM
mkg-795	161	8	.	.	PUNCT