id	sid	tid	token	lemma	pos
mkg-954	1	1	141	141	NUM
mkg-954	1	2	vol	vol	NOUN
mkg-954	1	3	.	.	PUNCT
mkg-954	2	1	42	42	NUM
mkg-954	2	2	.	.	PUNCT
mkg-954	3	1	no	no	INTJ
mkg-954	3	2	.	.	NOUN
mkg-954	4	1	3	3	NUM
mkg-954	4	2	july	july	PROPN
mkg-954	4	3	–	–	PUNCT
mkg-954	4	4	september	september	PROPN
mkg-954	4	5	2009	2009	NUM
mkg-954	4	6	review	review	NOUN
mkg-954	4	7	article	article	NOUN
mkg-954	4	8	the	the	DET
mkg-954	4	9	role	role	NOUN
mkg-954	4	10	of	of	ADP
mkg-954	4	11	msx1	msx1	PROPN
mkg-954	4	12	and	and	CCONJ
mkg-954	4	13	pax9	pax9	NOUN
mkg-954	4	14	in	in	ADP
mkg-954	4	15	pathogenetic	pathogenetic	ADJ
mkg-954	4	16	mechanisms	mechanism	NOUN
mkg-954	4	17	of	of	ADP
mkg-954	4	18	tooth	tooth	NOUN
mkg-954	4	19	agenesis	agenesis	NOUN
mkg-954	4	20	yani	yani	PROPN
mkg-954	4	21	corvianindya	corvianindya	PROPN
mkg-954	4	22	rahayu1	rahayu1	PROPN
mkg-954	4	23	and	and	CCONJ
mkg-954	4	24	dyah	dyah	NOUN
mkg-954	4	25	setyorini2	setyorini2	VERB
mkg-954	4	26	1	1	NUM
mkg-954	4	27	departement	departement	NOUN
mkg-954	4	28	of	of	ADP
mkg-954	4	29	oral	oral	ADJ
mkg-954	4	30	biology	biology	NOUN
mkg-954	4	31	2	2	NUM
mkg-954	4	32	departement	departement	NOUN
mkg-954	4	33	of	of	ADP
mkg-954	4	34	pediatric	pediatric	ADJ
mkg-954	4	35	dentistry	dentistry	NOUN
mkg-954	4	36	faculty	faculty	NOUN
mkg-954	4	37	of	of	ADP
mkg-954	4	38	dentistry	dentistry	PROPN
mkg-954	4	39	university	university	PROPN
mkg-954	4	40	of	of	ADP
mkg-954	4	41	jember	jember	PROPN
mkg-954	4	42	jember	jember	PROPN
mkg-954	4	43	indonesia	indonesia	PROPN
mkg-954	4	44	abstract	abstract	ADJ
mkg-954	4	45	background	background	NOUN
mkg-954	4	46	:	:	PUNCT
mkg-954	4	47	tooth	tooth	NOUN
mkg-954	4	48	agenesis	agenesis	NOUN
mkg-954	4	49	is	be	AUX
mkg-954	4	50	one	one	NUM
mkg-954	4	51	of	of	ADP
mkg-954	4	52	the	the	DET
mkg-954	4	53	most	most	ADV
mkg-954	4	54	common	common	ADJ
mkg-954	4	55	developmental	developmental	ADJ
mkg-954	4	56	anomalies	anomaly	NOUN
mkg-954	4	57	in	in	ADP
mkg-954	4	58	human	human	NOUN
mkg-954	4	59	,	,	PUNCT
mkg-954	4	60	which	which	PRON
mkg-954	4	61	one	one	NUM
mkg-954	4	62	or	or	CCONJ
mkg-954	4	63	a	a	DET
mkg-954	4	64	few	few	ADJ
mkg-954	4	65	teeth	tooth	NOUN
mkg-954	4	66	are	be	AUX
mkg-954	4	67	absent	absent	ADJ
mkg-954	4	68	because	because	SCONJ
mkg-954	4	69	they	they	PRON
mkg-954	4	70	have	have	AUX
mkg-954	4	71	never	never	ADV
mkg-954	4	72	formed	form	VERB
mkg-954	4	73	,	,	PUNCT
mkg-954	4	74	may	may	AUX
mkg-954	4	75	cause	cause	VERB
mkg-954	4	76	cosmetic	cosmetic	ADJ
mkg-954	4	77	or	or	CCONJ
mkg-954	4	78	occlusal	occlusal	ADJ
mkg-954	4	79	harm	harm	NOUN
mkg-954	4	80	,	,	PUNCT
mkg-954	4	81	while	while	SCONJ
mkg-954	4	82	severe	severe	ADJ
mkg-954	4	83	agenesis	agenesis	NOUN
mkg-954	4	84	which	which	PRON
mkg-954	4	85	are	be	AUX
mkg-954	4	86	relatively	relatively	ADV
mkg-954	4	87	rare	rare	ADJ
mkg-954	4	88	require	require	NOUN
mkg-954	4	89	clinical	clinical	ADJ
mkg-954	4	90	,	,	PUNCT
mkg-954	4	91	may	may	AUX
mkg-954	4	92	cause	cause	VERB
mkg-954	4	93	cosmetic	cosmetic	ADJ
mkg-954	4	94	or	or	CCONJ
mkg-954	4	95	occlusal	occlusal	ADJ
mkg-954	4	96	harm	harm	NOUN
mkg-954	4	97	,	,	PUNCT
mkg-954	4	98	while	while	SCONJ
mkg-954	4	99	severe	severe	ADJ
mkg-954	4	100	agenesis	agenesis	NOUN
mkg-954	4	101	which	which	PRON
mkg-954	4	102	are	be	AUX
mkg-954	4	103	relatively	relatively	ADV
mkg-954	4	104	rare	rare	ADJ
mkg-954	4	105	require	require	ADJ
mkg-954	4	106	clinical	clinical	ADJ
mkg-954	4	107	attention	attention	NOUN
mkg-954	4	108	to	to	PART
mkg-954	4	109	support	support	VERB
mkg-954	4	110	and	and	CCONJ
mkg-954	4	111	maintain	maintain	VERB
mkg-954	4	112	the	the	DET
mkg-954	4	113	dental	dental	ADJ
mkg-954	4	114	function	function	NOUN
mkg-954	4	115	.	.	PUNCT
mkg-954	5	1	molecular	molecular	ADJ
mkg-954	5	2	studies	study	NOUN
mkg-954	5	3	have	have	AUX
mkg-954	5	4	demonstrated	demonstrate	VERB
mkg-954	5	5	that	that	SCONJ
mkg-954	5	6	tooth	tooth	NOUN
mkg-954	5	7	development	development	NOUN
mkg-954	5	8	is	be	AUX
mkg-954	5	9	under	under	ADP
mkg-954	5	10	strict	strict	ADJ
mkg-954	5	11	genetic	genetic	ADJ
mkg-954	5	12	control	control	NOUN
mkg-954	5	13	.	.	PUNCT
mkg-954	6	1	purpose	purpose	NOUN
mkg-954	6	2	:	:	PUNCT
mkg-954	6	3	this	this	DET
mkg-954	6	4	article	article	NOUN
mkg-954	6	5	want	want	VERB
mkg-954	6	6	to	to	PART
mkg-954	6	7	review	review	VERB
mkg-954	6	8	the	the	DET
mkg-954	6	9	genetic	genetic	ADJ
mkg-954	6	10	regulating	regulating	NOUN
mkg-954	6	11	that	that	PRON
mkg-954	6	12	are	be	AUX
mkg-954	6	13	responsible	responsible	ADJ
mkg-954	6	14	for	for	ADP
mkg-954	6	15	tooth	tooth	NOUN
mkg-954	6	16	agenesis	agenesis	NOUN
mkg-954	6	17	especially	especially	ADV
mkg-954	6	18	the	the	DET
mkg-954	6	19	role	role	NOUN
mkg-954	6	20	of	of	ADP
mkg-954	6	21	msx1	msx1	PROPN
mkg-954	6	22	and	and	CCONJ
mkg-954	6	23	pax9	pax9	NOUN
mkg-954	6	24	in	in	ADP
mkg-954	6	25	pathogenetic	pathogenetic	ADJ
mkg-954	6	26	mechanisms	mechanism	NOUN
mkg-954	6	27	of	of	ADP
mkg-954	6	28	tooth	tooth	NOUN
mkg-954	6	29	agenesis	agenesis	NOUN
mkg-954	6	30	.	.	PUNCT
mkg-954	7	1	review	review	NOUN
mkg-954	7	2	:	:	PUNCT
mkg-954	7	3	tooth	tooth	NOUN
mkg-954	7	4	agenesis	agenesis	NOUN
mkg-954	7	5	is	be	AUX
mkg-954	7	6	a	a	DET
mkg-954	7	7	consequence	consequence	NOUN
mkg-954	7	8	of	of	ADP
mkg-954	7	9	a	a	DET
mkg-954	7	10	qualitatively	qualitatively	ADV
mkg-954	7	11	or	or	CCONJ
mkg-954	7	12	quantitativelyooth	quantitativelyooth	NOUN
mkg-954	7	13	agenesis	agenesis	NOUN
mkg-954	7	14	is	be	AUX
mkg-954	7	15	a	a	DET
mkg-954	7	16	consequence	consequence	NOUN
mkg-954	7	17	of	of	ADP
mkg-954	7	18	a	a	DET
mkg-954	7	19	qualitatively	qualitatively	ADV
mkg-954	7	20	or	or	CCONJ
mkg-954	7	21	quantitatively	quantitatively	ADV
mkg-954	7	22	impaired	impaired	ADJ
mkg-954	7	23	function	function	NOUN
mkg-954	7	24	of	of	ADP
mkg-954	7	25	genetic	genetic	ADJ
mkg-954	7	26	networks	network	NOUN
mkg-954	7	27	,	,	PUNCT
mkg-954	7	28	which	which	PRON
mkg-954	7	29	regulate	regulate	VERB
mkg-954	7	30	tooth	tooth	NOUN
mkg-954	7	31	development	development	NOUN
mkg-954	7	32	.	.	PUNCT
mkg-954	8	1	mutations	mutation	NOUN
mkg-954	8	2	in	in	ADP
mkg-954	8	3	msx1	msx1	PROPN
mkg-954	8	4	and	and	CCONJ
mkg-954	8	5	pax9	pax9	NOUN
mkg-954	8	6	genes	gene	NOUN
mkg-954	8	7	are	be	AUX
mkg-954	8	8	dominant	dominant	ADJ
mkg-954	8	9	for	for	ADP
mkg-954	8	10	tooth	tooth	NOUN
mkg-954	8	11	agenesis	agenesis	NOUN
mkg-954	8	12	in	in	ADP
mkg-954	8	13	humans	human	NOUN
mkg-954	8	14	.	.	PUNCT
mkg-954	9	1	the	the	DET
mkg-954	9	2	pax9	pax9	NOUN
mkg-954	9	3	gene	gene	NOUN
mkg-954	9	4	,	,	PUNCT
mkg-954	9	5	which	which	PRON
mkg-954	9	6	codes	code	VERB
mkg-954	9	7	for	for	ADP
mkg-954	9	8	a	a	DET
mkg-954	9	9	paired	pair	VERB
mkg-954	9	10	domain	domain	NOUN
mkg-954	9	11	-	-	PUNCT
mkg-954	9	12	containing	contain	VERB
mkg-954	9	13	transcription	transcription	NOUN
mkg-954	9	14	factor	factor	NOUN
mkg-954	9	15	that	that	PRON
mkg-954	9	16	plays	play	VERB
mkg-954	9	17	an	an	DET
mkg-954	9	18	essential	essential	ADJ
mkg-954	9	19	role	role	NOUN
mkg-954	9	20	in	in	ADP
mkg-954	9	21	the	the	DET
mkg-954	9	22	development	development	NOUN
mkg-954	9	23	of	of	ADP
mkg-954	9	24	mammal	mammal	ADJ
mkg-954	9	25	dentition	dentition	NOUN
mkg-954	9	26	,	,	PUNCT
mkg-954	9	27	has	have	AUX
mkg-954	9	28	been	be	AUX
mkg-954	9	29	associated	associate	VERB
mkg-954	9	30	with	with	ADP
mkg-954	9	31	selective	selective	ADJ
mkg-954	9	32	tooth	tooth	NOUN
mkg-954	9	33	agenesis	agenesis	NOUN
mkg-954	9	34	in	in	ADP
mkg-954	9	35	humans	human	NOUN
mkg-954	9	36	and	and	CCONJ
mkg-954	9	37	mice	mouse	NOUN
mkg-954	9	38	.	.	PUNCT
mkg-954	10	1	conclusion	conclusion	NOUN
mkg-954	10	2	:	:	PUNCT
mkg-954	10	3	reduced	reduce	VERB
mkg-954	10	4	amount	amount	NOUN
mkg-954	10	5	of	of	ADP
mkg-954	10	6	functional	functional	ADJ
mkg-954	10	7	msx1	msx1	NOUN
mkg-954	10	8	or	or	CCONJ
mkg-954	10	9	pax9	pax9	NOUN
mkg-954	10	10	protein	protein	NOUN
mkg-954	10	11	in	in	ADP
mkg-954	10	12	the	the	DET
mkg-954	10	13	tooth	tooth	NOUN
mkg-954	10	14	forming	form	VERB
mkg-954	10	15	cells	cell	NOUN
mkg-954	10	16	is	be	AUX
mkg-954	10	17	able	able	ADJ
mkg-954	10	18	to	to	PART
mkg-954	10	19	cause	cause	VERB
mkg-954	10	20	severe	severe	ADJ
mkg-954	10	21	and	and	CCONJ
mkg-954	10	22	selective	selective	ADJ
mkg-954	10	23	tooth	tooth	NOUN
mkg-954	10	24	agenesis	agenesis	NOUN
mkg-954	10	25	.	.	PUNCT
mkg-954	11	1	there	there	PRON
mkg-954	11	2	are	be	VERB
mkg-954	11	3	differences	difference	NOUN
mkg-954	11	4	in	in	ADP
mkg-954	11	5	the	the	DET
mkg-954	11	6	frequency	frequency	NOUN
mkg-954	11	7	of	of	ADP
mkg-954	11	8	agenesis	agenesis	NOUN
mkg-954	11	9	of	of	ADP
mkg-954	11	10	specific	specific	ADJ
mkg-954	11	11	teeth	tooth	NOUN
mkg-954	11	12	associated	associate	VERB
mkg-954	11	13	with	with	ADP
mkg-954	11	14	the	the	DET
mkg-954	11	15	defects	defect	NOUN
mkg-954	11	16	in	in	ADP
mkg-954	11	17	msx1	msx1	NOUN
mkg-954	11	18	and	and	CCONJ
mkg-954	11	19	defects	defect	NOUN
mkg-954	11	20	in	in	ADP
mkg-954	11	21	pax9	pax9	PROPN
mkg-954	11	22	.	.	PUNCT
mkg-954	12	1	key	key	ADJ
mkg-954	12	2	words	word	NOUN
mkg-954	12	3	:	:	PUNCT
mkg-954	12	4	tooth	tooth	NOUN
mkg-954	12	5	agenesis	agenesis	NOUN
mkg-954	12	6	,	,	PUNCT
mkg-954	12	7	genetic	genetic	ADJ
mkg-954	12	8	regulation	regulation	NOUN
mkg-954	12	9	,	,	PUNCT
mkg-954	12	10	pathogenetic	pathogenetic	ADJ
mkg-954	12	11	mechanisms	mechanism	NOUN
mkg-954	12	12	,	,	PUNCT
mkg-954	12	13	msx1	msx1	PROPN
mkg-954	12	14	,	,	PUNCT
mkg-954	12	15	pax9	pax9	NOUN
mkg-954	12	16	correspondence	correspondence	NOUN
mkg-954	12	17	:	:	PUNCT
mkg-954	12	18	yani	yani	PROPN
mkg-954	12	19	corvianindya	corvianindya	PROPN
mkg-954	12	20	rahayu	rahayu	PROPN
mkg-954	12	21	,	,	PUNCT
mkg-954	12	22	c	c	X
mkg-954	12	23	/	/	SYM
mkg-954	12	24	o	o	NOUN
mkg-954	12	25	:	:	PUNCT
mkg-954	12	26	bagian	bagian	PROPN
mkg-954	12	27	biologi	biologi	PROPN
mkg-954	12	28	oral	oral	NOUN
mkg-954	12	29	,	,	PUNCT
mkg-954	12	30	fakultas	fakulta	VERB
mkg-954	12	31	kedokteran	kedokteran	PROPN
mkg-954	12	32	gigi	gigi	PROPN
mkg-954	12	33	universitas	universitas	PROPN
mkg-954	12	34	jember	jember	PROPN
mkg-954	12	35	.	.	PUNCT
mkg-954	13	1	jln	jln	PROPN
mkg-954	13	2	.	.	PROPN
mkg-954	13	3	kalimantan	kalimantan	PROPN
mkg-954	13	4	37	37	NUM
mkg-954	13	5	jember	jember	PROPN
mkg-954	13	6	68121	68121	NUM
mkg-954	13	7	,	,	PUNCT
mkg-954	13	8	indonesia	indonesia	PROPN
mkg-954	13	9	.	.	PUNCT
mkg-954	14	1	e	e	X
mkg-954	14	2	-	-	NOUN
mkg-954	14	3	mail	mail	NOUN
mkg-954	14	4	:	:	PUNCT
mkg-954	15	1	ryanicorvianindya@yahoo.com	ryanicorvianindya@yahoo.com	X
mkg-954	15	2	introduction	introduction	NOUN
mkg-954	15	3	during	during	ADP
mkg-954	15	4	the	the	DET
mkg-954	15	5	last	last	ADJ
mkg-954	15	6	decades	decade	NOUN
mkg-954	15	7	after	after	ADP
mkg-954	15	8	the	the	DET
mkg-954	15	9	advent	advent	NOUN
mkg-954	15	10	of	of	ADP
mkg-954	15	11	molecular	molecular	ADJ
mkg-954	15	12	biology	biology	NOUN
mkg-954	15	13	and	and	CCONJ
mkg-954	15	14	genetics	genetic	NOUN
mkg-954	15	15	,	,	PUNCT
mkg-954	15	16	the	the	DET
mkg-954	15	17	new	new	ADJ
mkg-954	15	18	technologies	technology	NOUN
mkg-954	15	19	have	have	AUX
mkg-954	15	20	been	be	AUX
mkg-954	15	21	extensively	extensively	ADV
mkg-954	15	22	used	use	VERB
mkg-954	15	23	to	to	PART
mkg-954	15	24	elucidate	elucidate	VERB
mkg-954	15	25	developmental	developmental	ADJ
mkg-954	15	26	mechanisms	mechanism	NOUN
mkg-954	15	27	and	and	CCONJ
mkg-954	15	28	the	the	DET
mkg-954	15	29	genetic	genetic	ADJ
mkg-954	15	30	regulation	regulation	NOUN
mkg-954	15	31	of	of	ADP
mkg-954	15	32	tooth	tooth	NOUN
mkg-954	15	33	development	development	NOUN
mkg-954	15	34	.	.	PUNCT
mkg-954	16	1	the	the	DET
mkg-954	16	2	positional	positional	ADJ
mkg-954	16	3	cloning	cloning	NOUN
mkg-954	16	4	of	of	ADP
mkg-954	16	5	several	several	ADJ
mkg-954	16	6	genes	gene	NOUN
mkg-954	16	7	that	that	PRON
mkg-954	16	8	cause	cause	VERB
mkg-954	16	9	different	different	ADJ
mkg-954	16	10	developmental	developmental	ADJ
mkg-954	16	11	dental	dental	ADJ
mkg-954	16	12	anomalies	anomaly	NOUN
mkg-954	16	13	,	,	PUNCT
mkg-954	16	14	have	have	AUX
mkg-954	16	15	contributed	contribute	VERB
mkg-954	16	16	to	to	ADP
mkg-954	16	17	understanding	understanding	NOUN
mkg-954	16	18	of	of	ADP
mkg-954	16	19	the	the	DET
mkg-954	16	20	genetic	genetic	ADJ
mkg-954	16	21	regulation	regulation	NOUN
mkg-954	16	22	of	of	ADP
mkg-954	16	23	developmental	developmental	NOUN
mkg-954	16	24	and	and	CCONJ
mkg-954	16	25	patterning	patterning	NOUN
mkg-954	16	26	of	of	ADP
mkg-954	16	27	the	the	DET
mkg-954	16	28	human	human	ADJ
mkg-954	16	29	dentition.1	dentition.1	PROPN
mkg-954	16	30	agenesis	agenesis	NOUN
mkg-954	16	31	of	of	ADP
mkg-954	16	32	one	one	NUM
mkg-954	16	33	or	or	CCONJ
mkg-954	16	34	more	more	ADJ
mkg-954	16	35	teeth	tooth	NOUN
mkg-954	16	36	is	be	AUX
mkg-954	16	37	one	one	NUM
mkg-954	16	38	of	of	ADP
mkg-954	16	39	the	the	DET
mkg-954	16	40	most	most	ADV
mkg-954	16	41	common	common	ADJ
mkg-954	16	42	of	of	ADP
mkg-954	16	43	human	human	ADJ
mkg-954	16	44	developmental	developmental	ADJ
mkg-954	16	45	anomalies	anomaly	NOUN
mkg-954	16	46	.	.	PUNCT
mkg-954	17	1	the	the	DET
mkg-954	17	2	term	term	NOUN
mkg-954	17	3	oligodontia	oligodontia	ADV
mkg-954	17	4	refers	refer	VERB
mkg-954	17	5	to	to	ADP
mkg-954	17	6	congenital	congenital	ADJ
mkg-954	17	7	absence	absence	NOUN
mkg-954	17	8	of	of	ADP
mkg-954	17	9	many	many	ADJ
mkg-954	17	10	but	but	CCONJ
mkg-954	17	11	not	not	PART
mkg-954	17	12	all	all	PRON
mkg-954	17	13	teeth	tooth	NOUN
mkg-954	17	14	whereas	whereas	SCONJ
mkg-954	17	15	the	the	DET
mkg-954	17	16	term	term	NOUN
mkg-954	17	17	hypodontia	hypodontia	PROPN
mkg-954	17	18	implies	imply	VERB
mkg-954	17	19	the	the	DET
mkg-954	17	20	absence	absence	NOUN
mkg-954	17	21	of	of	ADP
mkg-954	17	22	only	only	ADV
mkg-954	17	23	a	a	DET
mkg-954	17	24	few	few	ADJ
mkg-954	17	25	teeth	tooth	NOUN
mkg-954	17	26	.	.	PUNCT
mkg-954	18	1	in	in	ADP
mkg-954	18	2	the	the	DET
mkg-954	18	3	permanent	permanent	ADJ
mkg-954	18	4	dentition	dentition	NOUN
mkg-954	18	5	,	,	PUNCT
mkg-954	18	6	hypodontia	hypodontia	PROPN
mkg-954	18	7	has	have	VERB
mkg-954	18	8	a	a	DET
mkg-954	18	9	prevalence	prevalence	NOUN
mkg-954	18	10	of	of	ADP
mkg-954	18	11	1.6	1.6	NUM
mkg-954	18	12	%	%	NOUN
mkg-954	18	13	to	to	ADP
mkg-954	18	14	9.6	9.6	NUM
mkg-954	18	15	%	%	NOUN
mkg-954	18	16	,	,	PUNCT
mkg-954	18	17	excluding	exclude	VERB
mkg-954	18	18	agenesis	agenesis	NOUN
mkg-954	18	19	of	of	ADP
mkg-954	18	20	the	the	DET
mkg-954	18	21	third	third	ADJ
mkg-954	18	22	molars	molar	NOUN
mkg-954	18	23	.	.	PUNCT
mkg-954	19	1	oligodontia	oligodontia	AUX
mkg-954	19	2	has	have	VERB
mkg-954	19	3	a	a	DET
mkg-954	19	4	population	population	NOUN
mkg-954	19	5	prevalence	prevalence	NOUN
mkg-954	19	6	of	of	ADP
mkg-954	19	7	0.3	0.3	NUM
mkg-954	19	8	%	%	NOUN
mkg-954	19	9	in	in	ADP
mkg-954	19	10	the	the	DET
mkg-954	19	11	permanent	permanent	ADJ
mkg-954	19	12	dentition	dentition	NOUN
mkg-954	19	13	.	.	PUNCT
mkg-954	20	1	it	it	PRON
mkg-954	20	2	occurs	occur	VERB
mkg-954	20	3	more	more	ADV
mkg-954	20	4	frequently	frequently	ADV
mkg-954	20	5	in	in	ADP
mkg-954	20	6	girls	girl	NOUN
mkg-954	20	7	at	at	ADP
mkg-954	20	8	a	a	DET
mkg-954	20	9	ratio	ratio	NOUN
mkg-954	20	10	of	of	ADP
mkg-954	20	11	3:2	3:2	NUM
mkg-954	20	12	.	.	PUNCT
mkg-954	20	13	agenesis	agenesis	NOUN
mkg-954	20	14	of	of	ADP
mkg-954	20	15	only	only	ADV
mkg-954	20	16	the	the	DET
mkg-954	20	17	third	third	ADJ
mkg-954	20	18	molars	molar	NOUN
mkg-954	20	19	has	have	VERB
mkg-954	20	20	prevalence	prevalence	NOUN
mkg-954	20	21	between	between	ADP
mkg-954	20	22	9	9	NUM
mkg-954	20	23	%	%	NOUN
mkg-954	20	24	and	and	CCONJ
mkg-954	20	25	37	37	NUM
mkg-954	20	26	%	%	NOUN
mkg-954	20	27	.	.	PUNCT
mkg-954	21	1	in	in	ADP
mkg-954	21	2	the	the	DET
mkg-954	21	3	deciduous	deciduous	ADJ
mkg-954	21	4	dentition	dentition	NOUN
mkg-954	21	5	,	,	PUNCT
mkg-954	21	6	hypodontia	hypodontia	PROPN
mkg-954	21	7	occurs	occur	VERB
mkg-954	21	8	less	less	ADV
mkg-954	21	9	often	often	ADV
mkg-954	21	10	(	(	PUNCT
mkg-954	21	11	0.1%-0.9	0.1%-0.9	NUM
mkg-954	21	12	%	%	NOUN
mkg-954	21	13	)	)	PUNCT
mkg-954	21	14	and	and	CCONJ
mkg-954	21	15	has	have	VERB
mkg-954	21	16	no	no	DET
mkg-954	21	17	significant	significant	ADJ
mkg-954	21	18	sex	sex	NOUN
mkg-954	21	19	distribution.2	distribution.2	PROPN
mkg-954	21	20	both	both	CCONJ
mkg-954	21	21	environmental	environmental	ADJ
mkg-954	21	22	and	and	CCONJ
mkg-954	21	23	genetic	genetic	ADJ
mkg-954	21	24	factors	factor	NOUN
mkg-954	21	25	can	can	AUX
mkg-954	21	26	cause	cause	VERB
mkg-954	21	27	failure	failure	NOUN
mkg-954	21	28	of	of	ADP
mkg-954	21	29	tooth	tooth	NOUN
mkg-954	21	30	development	development	NOUN
mkg-954	21	31	.	.	PUNCT
mkg-954	22	1	numerous	numerous	ADJ
mkg-954	22	2	different	different	ADJ
mkg-954	22	3	genes	gene	NOUN
mkg-954	22	4	have	have	AUX
mkg-954	22	5	been	be	AUX
mkg-954	22	6	implicated	implicate	VERB
mkg-954	22	7	in	in	ADP
mkg-954	22	8	tooth	tooth	NOUN
mkg-954	22	9	development	development	NOUN
mkg-954	22	10	by	by	ADP
mkg-954	22	11	genes	gene	NOUN
mkg-954	22	12	expression	expression	NOUN
mkg-954	22	13	and	and	CCONJ
mkg-954	22	14	experimental	experimental	ADJ
mkg-954	22	15	studies	study	NOUN
mkg-954	22	16	in	in	ADP
mkg-954	22	17	the	the	DET
mkg-954	22	18	mouse	mouse	NOUN
mkg-954	22	19	,	,	PUNCT
mkg-954	22	20	and	and	CCONJ
mkg-954	22	21	any	any	PRON
mkg-954	22	22	of	of	ADP
mkg-954	22	23	these	these	DET
mkg-954	22	24	genes	gene	NOUN
mkg-954	22	25	may	may	AUX
mkg-954	22	26	cause	cause	VERB
mkg-954	22	27	tooth	tooth	NOUN
mkg-954	22	28	agenesis	agenesis	NOUN
mkg-954	22	29	.	.	PUNCT
mkg-954	23	1	variability	variability	NOUN
mkg-954	23	2	in	in	ADP
mkg-954	23	3	expression	expression	NOUN
mkg-954	23	4	includes	include	VERB
mkg-954	23	5	the	the	DET
mkg-954	23	6	number	number	NOUN
mkg-954	23	7	and	and	CCONJ
mkg-954	23	8	region	region	NOUN
mkg-954	23	9	of	of	ADP
mkg-954	23	10	missing	miss	VERB
mkg-954	23	11	teeth	tooth	NOUN
mkg-954	23	12	,	,	PUNCT
mkg-954	23	13	and	and	CCONJ
mkg-954	23	14	various	various	ADJ
mkg-954	23	15	other	other	ADJ
mkg-954	23	16	dental	dental	ADJ
mkg-954	23	17	features	feature	NOUN
mkg-954	23	18	associated	associate	VERB
mkg-954	23	19	with	with	ADP
mkg-954	23	20	the	the	DET
mkg-954	23	21	trait.3,4	trait.3,4	PROPN
mkg-954	23	22	the	the	DET
mkg-954	23	23	present	present	ADJ
mkg-954	23	24	study	study	NOUN
mkg-954	23	25	confirmed	confirm	VERB
mkg-954	23	26	the	the	DET
mkg-954	23	27	results	result	NOUN
mkg-954	23	28	of	of	ADP
mkg-954	23	29	garn	garn	NOUN
mkg-954	23	30	and	and	CCONJ
mkg-954	23	31	lewis5	lewis5	NOUN
mkg-954	23	32	showing	show	VERB
mkg-954	23	33	other	other	ADJ
mkg-954	23	34	physical	physical	ADJ
mkg-954	23	35	dental	dental	ADJ
mkg-954	23	36	traits	trait	NOUN
mkg-954	23	37	associated	associate	VERB
mkg-954	23	38	with	with	ADP
mkg-954	23	39	the	the	DET
mkg-954	23	40	occurrence	occurrence	NOUN
mkg-954	23	41	of	of	ADP
mkg-954	23	42	tooth	tooth	NOUN
mkg-954	23	43	agenesis	agenesis	NOUN
mkg-954	23	44	.	.	PUNCT
mkg-954	24	1	it	it	PRON
mkg-954	24	2	contributes	contribute	VERB
mkg-954	24	3	to	to	PART
mkg-954	24	4	mount	mount	VERB
mkg-954	24	5	the	the	DET
mkg-954	24	6	evidence	evidence	NOUN
mkg-954	24	7	that	that	SCONJ
mkg-954	24	8	agenesis	agenesis	NOUN
mkg-954	24	9	and	and	CCONJ
mkg-954	24	10	its	its	PRON
mkg-954	24	11	associated	associated	ADJ
mkg-954	24	12	abnormalities	abnormality	NOUN
mkg-954	24	13	are	be	AUX
mkg-954	24	14	under	under	ADP
mkg-954	24	15	genetic	genetic	ADJ
mkg-954	24	16	control	control	NOUN
mkg-954	24	17	.	.	PUNCT
mkg-954	25	1	the	the	DET
mkg-954	25	2	possible	possible	ADJ
mkg-954	25	3	explanation	explanation	NOUN
mkg-954	25	4	is	be	AUX
mkg-954	25	5	that	that	SCONJ
mkg-954	25	6	a	a	DET
mkg-954	25	7	single	single	ADJ
mkg-954	25	8	genetic	genetic	ADJ
mkg-954	25	9	defect	defect	NOUN
mkg-954	25	10	may	may	AUX
mkg-954	25	11	give	give	VERB
mkg-954	25	12	rise	rise	NOUN
mkg-954	25	13	to	to	ADP
mkg-954	25	14	different	different	ADJ
mkg-954	25	15	anomalies	anomaly	NOUN
mkg-954	25	16	,	,	PUNCT
mkg-954	25	17	so	so	SCONJ
mkg-954	25	18	that	that	SCONJ
mkg-954	25	19	two	two	NUM
mkg-954	25	20	or	or	CCONJ
mkg-954	25	21	more	more	ADV
mkg-954	25	22	dental	dental	ADJ
mkg-954	25	23	anomalies	anomaly	NOUN
mkg-954	25	24	in	in	ADP
mkg-954	25	25	the	the	DET
mkg-954	25	26	same	same	ADJ
mkg-954	25	27	patient	patient	NOUN
mkg-954	25	28	may	may	AUX
mkg-954	25	29	present	present	VERB
mkg-954	25	30	a	a	DET
mkg-954	25	31	common	common	ADJ
mkg-954	25	32	genetic	genetic	ADJ
mkg-954	25	33	origin	origin	NOUN
mkg-954	25	34	.	.	PUNCT
mkg-954	26	1	studies	study	NOUN
mkg-954	26	2	of	of	ADP
mkg-954	26	3	families	family	NOUN
mkg-954	26	4	,	,	PUNCT
mkg-954	26	5	as	as	ADV
mkg-954	26	6	well	well	ADV
mkg-954	26	7	as	as	ADP
mkg-954	26	8	investigations	investigation	NOUN
mkg-954	26	9	of	of	ADP
mkg-954	26	10	the	the	DET
mkg-954	26	11	association	association	NOUN
mkg-954	26	12	of	of	ADP
mkg-954	26	13	agenesis	agenesis	NOUN
mkg-954	26	14	and	and	CCONJ
mkg-954	26	15	142	142	NUM
mkg-954	26	16	dent	dent	NOUN
mkg-954	26	17	.	.	PUNCT
mkg-954	27	1	j.	j.	PROPN
mkg-954	27	2	(	(	PUNCT
mkg-954	27	3	maj	maj	PROPN
mkg-954	27	4	.	.	PROPN
mkg-954	27	5	ked	ked	PROPN
mkg-954	27	6	.	.	PUNCT
mkg-954	28	1	gigi	gigi	PROPN
mkg-954	28	2	)	)	PUNCT
mkg-954	28	3	,	,	PUNCT
mkg-954	29	1	vol	vol	NOUN
mkg-954	29	2	.	.	PUNCT
mkg-954	30	1	42	42	NUM
mkg-954	30	2	.	.	PUNCT
mkg-954	31	1	no	no	INTJ
mkg-954	31	2	.	.	NOUN
mkg-954	32	1	3	3	NUM
mkg-954	32	2	july	july	PROPN
mkg-954	32	3	–	–	PUNCT
mkg-954	32	4	september	september	PROPN
mkg-954	32	5	2009	2009	NUM
mkg-954	32	6	:	:	PUNCT
mkg-954	32	7	141	141	NUM
mkg-954	32	8	-	-	SYM
mkg-954	32	9	146	146	NUM
mkg-954	32	10	other	other	ADJ
mkg-954	32	11	types	type	NOUN
mkg-954	32	12	of	of	ADP
mkg-954	32	13	dental	dental	ADJ
mkg-954	32	14	anomalies	anomaly	NOUN
mkg-954	32	15	,	,	PUNCT
mkg-954	32	16	previously	previously	ADV
mkg-954	32	17	highlighted	highlight	VERB
mkg-954	32	18	the	the	DET
mkg-954	32	19	role	role	NOUN
mkg-954	32	20	played	play	VERB
mkg-954	32	21	by	by	ADP
mkg-954	32	22	genetic	genetic	ADJ
mkg-954	32	23	mechanisms	mechanism	NOUN
mkg-954	32	24	in	in	ADP
mkg-954	32	25	the	the	DET
mkg-954	32	26	etiology	etiology	NOUN
mkg-954	32	27	of	of	ADP
mkg-954	32	28	various	various	ADJ
mkg-954	32	29	dental	dental	ADJ
mkg-954	32	30	anomalies.5,6	anomalies.5,6	NOUN
mkg-954	32	31	dental	dental	ADJ
mkg-954	32	32	anomalies	anomaly	NOUN
mkg-954	32	33	are	be	AUX
mkg-954	32	34	ideal	ideal	ADJ
mkg-954	32	35	conditions	condition	NOUN
mkg-954	32	36	for	for	SCONJ
mkg-954	32	37	the	the	DET
mkg-954	32	38	geneticist	geneticist	NOUN
mkg-954	32	39	to	to	PART
mkg-954	32	40	study	study	VERB
mkg-954	32	41	the	the	DET
mkg-954	32	42	hereditary	hereditary	ADJ
mkg-954	32	43	factors	factor	NOUN
mkg-954	32	44	involved	involve	VERB
mkg-954	32	45	in	in	ADP
mkg-954	32	46	their	their	PRON
mkg-954	32	47	pathogenesis	pathogenesis	NOUN
mkg-954	32	48	.	.	PUNCT
mkg-954	33	1	this	this	DET
mkg-954	33	2	article	article	NOUN
mkg-954	33	3	reviewed	review	VERB
mkg-954	33	4	the	the	DET
mkg-954	33	5	genetic	genetic	ADJ
mkg-954	33	6	regulating	regulating	NOUN
mkg-954	33	7	that	that	PRON
mkg-954	33	8	are	be	AUX
mkg-954	33	9	responsible	responsible	ADJ
mkg-954	33	10	for	for	ADP
mkg-954	33	11	tooth	tooth	NOUN
mkg-954	33	12	agenesis	agenesis	NOUN
mkg-954	33	13	especially	especially	ADV
mkg-954	33	14	the	the	DET
mkg-954	33	15	role	role	NOUN
mkg-954	33	16	of	of	ADP
mkg-954	33	17	msx1	msx1	PROPN
mkg-954	33	18	and	and	CCONJ
mkg-954	33	19	pax9	pax9	NOUN
mkg-954	33	20	in	in	ADP
mkg-954	33	21	pathogenetic	pathogenetic	ADJ
mkg-954	33	22	mechanisms	mechanism	NOUN
mkg-954	33	23	of	of	ADP
mkg-954	33	24	tooth	tooth	NOUN
mkg-954	33	25	agenesis	agenesis	NOUN
mkg-954	33	26	.	.	PUNCT
mkg-954	34	1	tooth	tooth	NOUN
mkg-954	34	2	morphogenesis	morphogenesis	NOUN
mkg-954	34	3	in	in	ADP
mkg-954	34	4	the	the	DET
mkg-954	34	5	late	late	ADJ
mkg-954	34	6	bud	bud	ADJ
mkg-954	34	7	stage	stage	NOUN
mkg-954	34	8	,	,	PUNCT
mkg-954	34	9	a	a	DET
mkg-954	34	10	group	group	NOUN
mkg-954	34	11	of	of	ADP
mkg-954	34	12	cells	cell	NOUN
mkg-954	34	13	at	at	ADP
mkg-954	34	14	the	the	DET
mkg-954	34	15	tip	tip	NOUN
mkg-954	34	16	of	of	ADP
mkg-954	34	17	the	the	DET
mkg-954	34	18	epithelial	epithelial	ADJ
mkg-954	34	19	bud	bud	NOUN
mkg-954	34	20	,	,	PUNCT
mkg-954	34	21	the	the	DET
mkg-954	34	22	primary	primary	ADJ
mkg-954	34	23	enamel	enamel	NOUN
mkg-954	34	24	knot	knot	NOUN
mkg-954	34	25	stop	stop	VERB
mkg-954	34	26	to	to	PART
mkg-954	34	27	proliferate	proliferate	VERB
mkg-954	34	28	and	and	CCONJ
mkg-954	34	29	then	then	ADV
mkg-954	34	30	removed	remove	VERB
mkg-954	34	31	by	by	ADP
mkg-954	34	32	apoptosis	apoptosis	NOUN
mkg-954	34	33	.	.	PUNCT
mkg-954	35	1	the	the	DET
mkg-954	35	2	enamel	enamel	NOUN
mkg-954	35	3	knot	knot	NOUN
mkg-954	35	4	deviates	deviate	VERB
mkg-954	35	5	significantly	significantly	ADV
mkg-954	35	6	from	from	ADP
mkg-954	35	7	the	the	DET
mkg-954	35	8	surrounding	surround	VERB
mkg-954	35	9	epithelium	epithelium	NOUN
mkg-954	35	10	because	because	SCONJ
mkg-954	35	11	of	of	ADP
mkg-954	35	12	its	its	PRON
mkg-954	35	13	gene	gene	NOUN
mkg-954	35	14	expression	expression	NOUN
mkg-954	35	15	.	.	PUNCT
mkg-954	36	1	it	it	PRON
mkg-954	36	2	expresses	express	VERB
mkg-954	36	3	several	several	ADJ
mkg-954	36	4	transcription	transcription	NOUN
mkg-954	36	5	factors	factor	NOUN
mkg-954	36	6	and	and	CCONJ
mkg-954	36	7	numerous	numerous	ADJ
mkg-954	36	8	signalling	signal	VERB
mkg-954	36	9	molecules	molecule	NOUN
mkg-954	36	10	as	as	ADV
mkg-954	36	11	well	well	ADV
mkg-954	36	12	as	as	ADP
mkg-954	36	13	signalling	signal	VERB
mkg-954	36	14	inhibitors	inhibitor	NOUN
mkg-954	36	15	with	with	ADP
mkg-954	36	16	a	a	DET
mkg-954	36	17	specific	specific	ADJ
mkg-954	36	18	schedule	schedule	NOUN
mkg-954	36	19	of	of	ADP
mkg-954	36	20	appearance	appearance	NOUN
mkg-954	36	21	,	,	PUNCT
mkg-954	36	22	thus	thus	ADV
mkg-954	36	23	having	have	VERB
mkg-954	36	24	potential	potential	NOUN
mkg-954	36	25	to	to	PART
mkg-954	36	26	act	act	VERB
mkg-954	36	27	as	as	ADP
mkg-954	36	28	a	a	DET
mkg-954	36	29	signalling	signal	VERB
mkg-954	36	30	centre	centre	NOUN
mkg-954	36	31	that	that	PRON
mkg-954	36	32	orchestrates	orchestrate	VERB
mkg-954	36	33	the	the	DET
mkg-954	36	34	development	development	NOUN
mkg-954	36	35	of	of	ADP
mkg-954	36	36	the	the	DET
mkg-954	36	37	surrounding	surround	VERB
mkg-954	36	38	tissues	tissue	NOUN
mkg-954	36	39	.	.	PUNCT
mkg-954	37	1	the	the	DET
mkg-954	37	2	primary	primary	ADJ
mkg-954	37	3	enamel	enamel	NOUN
mkg-954	37	4	knot	knot	NOUN
mkg-954	37	5	is	be	AUX
mkg-954	37	6	apparently	apparently	ADV
mkg-954	37	7	induced	induce	VERB
mkg-954	37	8	and	and	CCONJ
mkg-954	37	9	maintained	maintain	VERB
mkg-954	37	10	by	by	ADP
mkg-954	37	11	signals	signal	NOUN
mkg-954	37	12	emanating	emanate	VERB
mkg-954	37	13	from	from	ADP
mkg-954	37	14	the	the	DET
mkg-954	37	15	underlying	underlie	VERB
mkg-954	37	16	mesenchyme	mesenchyme	NOUN
mkg-954	37	17	.	.	PUNCT
mkg-954	38	1	on	on	ADP
mkg-954	38	2	the	the	DET
mkg-954	38	3	other	other	ADJ
mkg-954	38	4	hand	hand	NOUN
mkg-954	38	5	,	,	PUNCT
mkg-954	38	6	formation	formation	NOUN
mkg-954	38	7	of	of	ADP
mkg-954	38	8	the	the	DET
mkg-954	38	9	primary	primary	ADJ
mkg-954	38	10	knot	knot	NOUN
mkg-954	38	11	seems	seem	VERB
mkg-954	38	12	to	to	PART
mkg-954	38	13	be	be	AUX
mkg-954	38	14	a	a	DET
mkg-954	38	15	prerequisite	prerequisite	NOUN
mkg-954	38	16	for	for	ADP
mkg-954	38	17	the	the	DET
mkg-954	38	18	advancing	advancing	NOUN
mkg-954	38	19	of	of	ADP
mkg-954	38	20	the	the	DET
mkg-954	38	21	tooth	tooth	NOUN
mkg-954	38	22	development	development	NOUN
mkg-954	38	23	to	to	ADP
mkg-954	38	24	the	the	DET
mkg-954	38	25	cap	cap	NOUN
mkg-954	38	26	stage.7	stage.7	NOUN
mkg-954	38	27	the	the	DET
mkg-954	38	28	dental	dental	ADJ
mkg-954	38	29	lamina	lamina	NOUN
mkg-954	38	30	in	in	ADP
mkg-954	38	31	6th	6th	ADJ
mkg-954	38	32	week	week	NOUN
mkg-954	38	33	,	,	PUNCT
mkg-954	38	34	and	and	CCONJ
mkg-954	38	35	later	later	ADV
mkg-954	38	36	the	the	DET
mkg-954	38	37	enamel	enamel	NOUN
mkg-954	38	38	organs	organ	NOUN
mkg-954	38	39	,	,	PUNCT
mkg-954	38	40	represent	represent	VERB
mkg-954	38	41	the	the	DET
mkg-954	38	42	epithelial	epithelial	ADJ
mkg-954	38	43	portion	portion	NOUN
mkg-954	38	44	of	of	ADP
mkg-954	38	45	the	the	DET
mkg-954	38	46	oral	oral	ADJ
mkg-954	38	47	cavity	cavity	NOUN
mkg-954	38	48	with	with	ADP
mkg-954	38	49	potential	potential	ADJ
mkg-954	38	50	capacity	capacity	NOUN
mkg-954	38	51	to	to	PART
mkg-954	38	52	generate	generate	VERB
mkg-954	38	53	the	the	DET
mkg-954	38	54	ectodermal	ectodermal	ADJ
mkg-954	38	55	components	component	NOUN
mkg-954	38	56	of	of	ADP
mkg-954	38	57	the	the	DET
mkg-954	38	58	teeth	tooth	NOUN
mkg-954	38	59	.	.	PUNCT
mkg-954	39	1	in	in	ADP
mkg-954	39	2	subsequent	subsequent	ADJ
mkg-954	39	3	development	development	NOUN
mkg-954	39	4	,	,	PUNCT
mkg-954	39	5	the	the	DET
mkg-954	39	6	adjacent	adjacent	ADJ
mkg-954	39	7	mesenchymal	mesenchymal	ADJ
mkg-954	39	8	tissue	tissue	NOUN
mkg-954	39	9	will	will	AUX
mkg-954	39	10	proliferates	proliferate	VERB
mkg-954	39	11	and	and	CCONJ
mkg-954	39	12	condenses	condense	VERB
mkg-954	39	13	to	to	PART
mkg-954	39	14	form	form	VERB
mkg-954	39	15	other	other	ADJ
mkg-954	39	16	components	component	NOUN
mkg-954	39	17	and	and	CCONJ
mkg-954	39	18	portions	portion	NOUN
mkg-954	39	19	of	of	ADP
mkg-954	39	20	the	the	DET
mkg-954	39	21	future	future	ADJ
mkg-954	39	22	teeth	tooth	NOUN
mkg-954	39	23	.	.	PUNCT
mkg-954	40	1	the	the	DET
mkg-954	40	2	permanent	permanent	ADJ
mkg-954	40	3	-	-	PUNCT
mkg-954	40	4	teeth	tooth	NOUN
mkg-954	40	5	germs	germ	NOUN
mkg-954	40	6	are	be	AUX
mkg-954	40	7	developed	develop	VERB
mkg-954	40	8	later	later	ADV
mkg-954	40	9	.	.	PUNCT
mkg-954	41	1	they	they	PRON
mkg-954	41	2	originate	originate	VERB
mkg-954	41	3	from	from	ADP
mkg-954	41	4	the	the	DET
mkg-954	41	5	accessory	accessory	NOUN
mkg-954	41	6	dental	dental	ADJ
mkg-954	41	7	lamina	lamina	NOUN
mkg-954	41	8	,	,	PUNCT
mkg-954	41	9	in	in	ADP
mkg-954	41	10	the	the	DET
mkg-954	41	11	case	case	NOUN
mkg-954	41	12	of	of	ADP
mkg-954	41	13	molars	molar	NOUN
mkg-954	41	14	,	,	PUNCT
mkg-954	41	15	or	or	CCONJ
mkg-954	41	16	from	from	ADP
mkg-954	41	17	growth	growth	NOUN
mkg-954	41	18	of	of	ADP
mkg-954	41	19	the	the	DET
mkg-954	41	20	free	free	ADJ
mkg-954	41	21	edge	edge	NOUN
mkg-954	41	22	of	of	ADP
mkg-954	41	23	the	the	DET
mkg-954	41	24	dental	dental	ADJ
mkg-954	41	25	lamina	lamina	NOUN
mkg-954	41	26	on	on	ADP
mkg-954	41	27	its	its	PRON
mkg-954	41	28	lingual	lingual	ADJ
mkg-954	41	29	side	side	NOUN
mkg-954	41	30	for	for	ADP
mkg-954	41	31	the	the	DET
mkg-954	41	32	remaining	remain	VERB
mkg-954	41	33	permanent	permanent	ADJ
mkg-954	41	34	teeth	tooth	NOUN
mkg-954	41	35	.	.	PUNCT
mkg-954	42	1	the	the	DET
mkg-954	42	2	emergence	emergence	NOUN
mkg-954	42	3	or	or	CCONJ
mkg-954	42	4	eruption	eruption	NOUN
mkg-954	42	5	of	of	ADP
mkg-954	42	6	permanent	permanent	ADJ
mkg-954	42	7	dentition	dentition	NOUN
mkg-954	42	8	takes	take	VERB
mkg-954	42	9	place	place	NOUN
mkg-954	42	10	over	over	ADP
mkg-954	42	11	an	an	DET
mkg-954	42	12	extended	extended	ADJ
mkg-954	42	13	period	period	NOUN
mkg-954	42	14	ranging	range	VERB
mkg-954	42	15	from	from	ADP
mkg-954	42	16	7	7	NUM
mkg-954	42	17	to	to	PART
mkg-954	42	18	12	12	NUM
mkg-954	42	19	years	year	NOUN
mkg-954	42	20	,	,	PUNCT
mkg-954	42	21	apart	apart	ADV
mkg-954	42	22	from	from	ADP
mkg-954	42	23	the	the	DET
mkg-954	42	24	third	third	ADJ
mkg-954	42	25	molars	molar	NOUN
mkg-954	42	26	,	,	PUNCT
mkg-954	42	27	which	which	PRON
mkg-954	42	28	erupt	erupt	VERB
mkg-954	42	29	between	between	ADP
mkg-954	42	30	13	13	NUM
mkg-954	42	31	and	and	CCONJ
mkg-954	42	32	25	25	NUM
mkg-954	42	33	years	year	NOUN
mkg-954	42	34	,	,	PUNCT
mkg-954	42	35	although	although	SCONJ
mkg-954	42	36	sometimes	sometimes	ADV
mkg-954	42	37	they	they	PRON
mkg-954	42	38	fail	fail	VERB
mkg-954	42	39	to	to	PART
mkg-954	42	40	appear	appear	VERB
mkg-954	42	41	at	at	ADV
mkg-954	42	42	all	all	ADV
mkg-954	42	43	.	.	PUNCT
mkg-954	43	1	most	most	ADJ
mkg-954	43	2	dental	dental	ADJ
mkg-954	43	3	anomalies	anomaly	NOUN
mkg-954	43	4	are	be	AUX
mkg-954	43	5	more	more	ADV
mkg-954	43	6	frequent	frequent	ADJ
mkg-954	43	7	in	in	ADP
mkg-954	43	8	permanent	permanent	ADJ
mkg-954	43	9	than	than	ADP
mkg-954	43	10	in	in	ADP
mkg-954	43	11	deciduous	deciduous	ADJ
mkg-954	43	12	dentition	dentition	NOUN
mkg-954	43	13	.	.	PUNCT
mkg-954	44	1	with	with	ADP
mkg-954	44	2	regard	regard	NOUN
mkg-954	44	3	to	to	ADP
mkg-954	44	4	permanent	permanent	ADJ
mkg-954	44	5	dentition	dentition	NOUN
mkg-954	44	6	,	,	PUNCT
mkg-954	44	7	the	the	DET
mkg-954	44	8	lack	lack	NOUN
mkg-954	44	9	of	of	ADP
mkg-954	44	10	one	one	NUM
mkg-954	44	11	or	or	CCONJ
mkg-954	44	12	more	more	ADJ
mkg-954	44	13	teeth	tooth	NOUN
mkg-954	44	14	is	be	AUX
mkg-954	44	15	evident	evident	ADJ
mkg-954	44	16	in	in	ADP
mkg-954	44	17	about	about	ADP
mkg-954	44	18	1–2	1–2	NUM
mkg-954	44	19	%	%	NOUN
mkg-954	44	20	of	of	ADP
mkg-954	44	21	the	the	DET
mkg-954	44	22	population.8	population.8	ADJ
mkg-954	44	23	molecular	molecular	ADJ
mkg-954	44	24	regulation	regulation	NOUN
mkg-954	44	25	of	of	ADP
mkg-954	44	26	tooth	tooth	NOUN
mkg-954	44	27	development	development	NOUN
mkg-954	44	28	the	the	DET
mkg-954	44	29	technologies	technology	NOUN
mkg-954	44	30	of	of	ADP
mkg-954	44	31	molecular	molecular	ADJ
mkg-954	44	32	biology	biology	NOUN
mkg-954	44	33	and	and	CCONJ
mkg-954	44	34	genetics	genetic	NOUN
mkg-954	44	35	have	have	AUX
mkg-954	44	36	been	be	AUX
mkg-954	44	37	extensively	extensively	ADV
mkg-954	44	38	used	use	VERB
mkg-954	44	39	to	to	PART
mkg-954	44	40	elucidate	elucidate	VERB
mkg-954	44	41	developmental	developmental	ADJ
mkg-954	44	42	mechanisms	mechanism	NOUN
mkg-954	44	43	and	and	CCONJ
mkg-954	44	44	the	the	DET
mkg-954	44	45	genetic	genetic	ADJ
mkg-954	44	46	regulation	regulation	NOUN
mkg-954	44	47	of	of	ADP
mkg-954	44	48	tooth	tooth	NOUN
mkg-954	44	49	development	development	NOUN
mkg-954	44	50	.	.	PUNCT
mkg-954	45	1	the	the	DET
mkg-954	45	2	most	most	ADV
mkg-954	45	3	usual	usual	ADJ
mkg-954	45	4	model	model	NOUN
mkg-954	45	5	has	have	AUX
mkg-954	45	6	been	be	AUX
mkg-954	45	7	the	the	DET
mkg-954	45	8	mandibular	mandibular	ADJ
mkg-954	45	9	molar	molar	ADJ
mkg-954	45	10	teeth	tooth	NOUN
mkg-954	45	11	of	of	ADP
mkg-954	45	12	the	the	DET
mkg-954	45	13	mouse	mouse	NOUN
mkg-954	45	14	,	,	PUNCT
mkg-954	45	15	the	the	DET
mkg-954	45	16	most	most	ADV
mkg-954	45	17	practical	practical	ADJ
mkg-954	45	18	laboratory	laboratory	NOUN
mkg-954	45	19	animal	animal	NOUN
mkg-954	45	20	that	that	PRON
mkg-954	45	21	develops	develop	VERB
mkg-954	45	22	teeth	tooth	NOUN
mkg-954	45	23	.	.	PUNCT
mkg-954	46	1	immunohistology	immunohistology	NOUN
mkg-954	46	2	and	and	CCONJ
mkg-954	46	3	in	in	ADP
mkg-954	46	4	situ	situ	ADJ
mkg-954	46	5	hybridization	hybridization	NOUN
mkg-954	46	6	have	have	AUX
mkg-954	46	7	been	be	AUX
mkg-954	46	8	used	use	VERB
mkg-954	46	9	to	to	PART
mkg-954	46	10	study	study	VERB
mkg-954	46	11	gene	gene	NOUN
mkg-954	46	12	expression	expression	NOUN
mkg-954	46	13	during	during	ADP
mkg-954	46	14	mouse	mouse	NOUN
mkg-954	46	15	tooth	tooth	NOUN
mkg-954	46	16	development	development	NOUN
mkg-954	46	17	and	and	CCONJ
mkg-954	46	18	differentiation	differentiation	NOUN
mkg-954	46	19	.	.	PUNCT
mkg-954	47	1	natural	natural	ADJ
mkg-954	47	2	and	and	CCONJ
mkg-954	47	3	transgenic	transgenic	NOUN
mkg-954	47	4	mutant	mutant	ADJ
mkg-954	47	5	mice	mouse	NOUN
mkg-954	47	6	have	have	AUX
mkg-954	47	7	been	be	AUX
mkg-954	47	8	utilized	utilize	VERB
mkg-954	47	9	to	to	PART
mkg-954	47	10	reveal	reveal	VERB
mkg-954	47	11	gene	gene	NOUN
mkg-954	47	12	function	function	NOUN
mkg-954	47	13	.	.	PUNCT
mkg-954	48	1	tissue	tissue	NOUN
mkg-954	48	2	culture	culture	NOUN
mkg-954	48	3	of	of	ADP
mkg-954	48	4	whole	whole	ADJ
mkg-954	48	5	tooth	tooth	NOUN
mkg-954	48	6	or	or	CCONJ
mkg-954	48	7	jaw	jaw	NOUN
mkg-954	48	8	explants	explant	NOUN
mkg-954	48	9	as	as	ADV
mkg-954	48	10	well	well	ADV
mkg-954	48	11	as	as	ADP
mkg-954	48	12	culture	culture	NOUN
mkg-954	48	13	of	of	ADP
mkg-954	48	14	recombined	recombined	ADJ
mkg-954	48	15	tissues	tissue	NOUN
mkg-954	48	16	has	have	AUX
mkg-954	48	17	been	be	AUX
mkg-954	48	18	used	use	VERB
mkg-954	48	19	to	to	PART
mkg-954	48	20	study	study	VERB
mkg-954	48	21	effects	effect	NOUN
mkg-954	48	22	of	of	ADP
mkg-954	48	23	proteins	protein	NOUN
mkg-954	48	24	and	and	CCONJ
mkg-954	48	25	mutations	mutation	NOUN
mkg-954	48	26	.	.	PUNCT
mkg-954	49	1	this	this	DET
mkg-954	49	2	knowledge	knowledge	NOUN
mkg-954	49	3	is	be	AUX
mkg-954	49	4	applicable	applicable	ADJ
mkg-954	49	5	to	to	ADP
mkg-954	49	6	humans	human	NOUN
mkg-954	49	7	and	and	CCONJ
mkg-954	49	8	other	other	ADJ
mkg-954	49	9	mammals	mammal	NOUN
mkg-954	49	10	because	because	SCONJ
mkg-954	49	11	of	of	ADP
mkg-954	49	12	the	the	DET
mkg-954	49	13	conservation	conservation	NOUN
mkg-954	49	14	of	of	ADP
mkg-954	49	15	the	the	DET
mkg-954	49	16	basic	basic	ADJ
mkg-954	49	17	genetic	genetic	ADJ
mkg-954	49	18	and	and	CCONJ
mkg-954	49	19	developmental	developmental	ADJ
mkg-954	49	20	mechanisms.1,9	mechanisms.1,9	PROPN
mkg-954	49	21	molecular	molecular	ADJ
mkg-954	49	22	studies	study	NOUN
mkg-954	49	23	have	have	AUX
mkg-954	49	24	revealed	reveal	VERB
mkg-954	49	25	that	that	SCONJ
mkg-954	49	26	the	the	DET
mkg-954	49	27	instructive	instructive	ADJ
mkg-954	49	28	and	and	CCONJ
mkg-954	49	29	permissive	permissive	ADJ
mkg-954	49	30	tissue	tissue	NOUN
mkg-954	49	31	interactions	interaction	NOUN
mkg-954	49	32	during	during	ADP
mkg-954	49	33	mouse	mouse	NOUN
mkg-954	49	34	tooth	tooth	NOUN
mkg-954	49	35	development	development	NOUN
mkg-954	49	36	described	describe	VERB
mkg-954	49	37	above	above	ADV
mkg-954	49	38	are	be	AUX
mkg-954	49	39	mainly	mainly	ADV
mkg-954	49	40	mediated	mediate	VERB
mkg-954	49	41	by	by	ADP
mkg-954	49	42	growth	growth	NOUN
mkg-954	49	43	factor	factor	NOUN
mkg-954	49	44	signalling	signal	VERB
mkg-954	49	45	.	.	PUNCT
mkg-954	50	1	development	development	NOUN
mkg-954	50	2	from	from	ADP
mkg-954	50	3	initiation	initiation	NOUN
mkg-954	50	4	to	to	ADP
mkg-954	50	5	eruption	eruption	NOUN
mkg-954	50	6	is	be	AUX
mkg-954	50	7	governed	govern	VERB
mkg-954	50	8	by	by	ADP
mkg-954	50	9	a	a	DET
mkg-954	50	10	sequential	sequential	ADJ
mkg-954	50	11	and	and	CCONJ
mkg-954	50	12	reciprocal	reciprocal	ADJ
mkg-954	50	13	signalling	signal	VERB
mkg-954	50	14	process	process	NOUN
mkg-954	50	15	rather	rather	ADV
mkg-954	50	16	than	than	ADP
mkg-954	50	17	simple	simple	ADJ
mkg-954	50	18	one	one	NUM
mkg-954	50	19	-	-	PUNCT
mkg-954	50	20	way	way	NOUN
mkg-954	50	21	messages	message	NOUN
mkg-954	50	22	.	.	PUNCT
mkg-954	51	1	the	the	DET
mkg-954	51	2	signalling	signal	VERB
mkg-954	51	3	involves	involve	VERB
mkg-954	51	4	all	all	DET
mkg-954	51	5	major	major	ADJ
mkg-954	51	6	signalling	signal	VERB
mkg-954	51	7	pathways	pathway	NOUN
mkg-954	51	8	,	,	PUNCT
mkg-954	51	9	including	include	VERB
mkg-954	51	10	transforming	transform	VERB
mkg-954	51	11	growth	growth	NOUN
mkg-954	51	12	factor	factor	NOUN
mkg-954	51	13	b	b	PROPN
mkg-954	51	14	(	(	PUNCT
mkg-954	51	15	tgfb	tgfb	PROPN
mkg-954	51	16	)	)	PUNCT
mkg-954	51	17	,	,	PUNCT
mkg-954	51	18	fibroblast	fibroblast	ADJ
mkg-954	51	19	growth	growth	NOUN
mkg-954	51	20	factor	factor	NOUN
mkg-954	51	21	(	(	PUNCT
mkg-954	51	22	fgf	fgf	PROPN
mkg-954	51	23	)	)	PUNCT
mkg-954	51	24	,	,	PUNCT
mkg-954	51	25	sonic	sonic	ADJ
mkg-954	51	26	heghehog	heghehog	PROPN
mkg-954	51	27	(	(	PUNCT
mkg-954	51	28	shh	shh	NOUN
mkg-954	51	29	)	)	PUNCT
mkg-954	51	30	,	,	PUNCT
mkg-954	51	31	anhidrotic	anhidrotic	ADJ
mkg-954	51	32	ectodermal	ectodermal	ADJ
mkg-954	51	33	dysplasia	dysplasia	NOUN
mkg-954	51	34	(	(	PUNCT
mkg-954	51	35	eda	eda	PROPN
mkg-954	51	36	)	)	PUNCT
mkg-954	51	37	,	,	PUNCT
mkg-954	51	38	and	and	CCONJ
mkg-954	51	39	epidermal	epidermal	ADJ
mkg-954	51	40	growth	growth	NOUN
mkg-954	51	41	factor	factor	NOUN
mkg-954	51	42	(	(	PUNCT
mkg-954	51	43	egf	egf	PROPN
mkg-954	51	44	)	)	PUNCT
mkg-954	51	45	signalling	signalling	NOUN
mkg-954	51	46	,	,	PUNCT
mkg-954	51	47	and	and	CCONJ
mkg-954	51	48	studies	study	NOUN
mkg-954	51	49	with	with	ADP
mkg-954	51	50	mouse	mouse	NOUN
mkg-954	51	51	mutants	mutant	NOUN
mkg-954	51	52	have	have	AUX
mkg-954	51	53	shown	show	VERB
mkg-954	51	54	that	that	SCONJ
mkg-954	51	55	they	they	PRON
mkg-954	51	56	are	be	AUX
mkg-954	51	57	needed	need	VERB
mkg-954	51	58	simultaneously	simultaneously	ADV
mkg-954	51	59	during	during	ADP
mkg-954	51	60	critical	critical	ADJ
mkg-954	51	61	stages	stage	NOUN
mkg-954	51	62	of	of	ADP
mkg-954	51	63	development.9	development.9	PROPN
mkg-954	51	64	msx1	msx1	NOUN
mkg-954	51	65	and	and	CCONJ
mkg-954	51	66	pax9	pax9	NOUN
mkg-954	51	67	are	be	AUX
mkg-954	51	68	transcription	transcription	NOUN
mkg-954	51	69	factors	factor	NOUN
mkg-954	51	70	intimately	intimately	ADV
mkg-954	51	71	involved	involve	VERB
mkg-954	51	72	in	in	ADP
mkg-954	51	73	the	the	DET
mkg-954	51	74	genetic	genetic	ADJ
mkg-954	51	75	networks	network	NOUN
mkg-954	51	76	regulating	regulate	VERB
mkg-954	51	77	tooth	tooth	NOUN
mkg-954	51	78	development	development	NOUN
mkg-954	51	79	.	.	PUNCT
mkg-954	52	1	msx1	msx1	PROPN
mkg-954	52	2	contains	contain	VERB
mkg-954	52	3	a	a	DET
mkg-954	52	4	homeobox	homeobox	NOUN
mkg-954	52	5	which	which	PRON
mkg-954	52	6	binds	bind	VERB
mkg-954	52	7	to	to	ADP
mkg-954	52	8	specific	specific	ADJ
mkg-954	52	9	target	target	NOUN
mkg-954	52	10	sequences	sequence	NOUN
mkg-954	52	11	in	in	ADP
mkg-954	52	12	the	the	DET
mkg-954	52	13	dna	dna	NOUN
mkg-954	52	14	but	but	CCONJ
mkg-954	52	15	is	be	AUX
mkg-954	52	16	also	also	ADV
mkg-954	52	17	capable	capable	ADJ
mkg-954	52	18	to	to	ADP
mkg-954	52	19	proteins	protein	NOUN
mkg-954	52	20	interaction	interaction	NOUN
mkg-954	52	21	.	.	PUNCT
mkg-954	53	1	msx1	msx1	PROPN
mkg-954	53	2	has	have	AUX
mkg-954	53	3	often	often	ADV
mkg-954	53	4	been	be	AUX
mkg-954	53	5	considered	consider	VERB
mkg-954	53	6	rather	rather	ADV
mkg-954	53	7	as	as	ADP
mkg-954	53	8	a	a	DET
mkg-954	53	9	repressor	repressor	NOUN
mkg-954	53	10	than	than	ADP
mkg-954	53	11	activator	activator	NOUN
mkg-954	53	12	of	of	ADP
mkg-954	53	13	gene	gene	NOUN
mkg-954	53	14	expression	expression	NOUN
mkg-954	53	15	.	.	PUNCT
mkg-954	54	1	pax9	pax9	NOUN
mkg-954	54	2	belongs	belong	VERB
mkg-954	54	3	to	to	ADP
mkg-954	54	4	the	the	DET
mkg-954	54	5	paired	pair	VERB
mkg-954	54	6	-	-	PUNCT
mkg-954	54	7	box	box	NOUN
mkg-954	54	8	containing	contain	VERB
mkg-954	54	9	transcription	transcription	NOUN
mkg-954	54	10	factor	factor	NOUN
mkg-954	54	11	family	family	NOUN
mkg-954	54	12	,	,	PUNCT
mkg-954	54	13	and	and	CCONJ
mkg-954	54	14	is	be	AUX
mkg-954	54	15	one	one	NUM
mkg-954	54	16	of	of	ADP
mkg-954	54	17	the	the	DET
mkg-954	54	18	earliest	early	ADJ
mkg-954	54	19	mesenchymal	mesenchymal	ADJ
mkg-954	54	20	markers	marker	NOUN
mkg-954	54	21	of	of	ADP
mkg-954	54	22	the	the	DET
mkg-954	54	23	future	future	ADJ
mkg-954	54	24	tooth	tooth	NOUN
mkg-954	54	25	forming	form	VERB
mkg-954	54	26	positions	position	NOUN
mkg-954	54	27	in	in	ADP
mkg-954	54	28	mouse	mouse	NOUN
mkg-954	54	29	.	.	PUNCT
mkg-954	55	1	pax9	pax9	NOUN
mkg-954	55	2	is	be	AUX
mkg-954	55	3	regulated	regulate	VERB
mkg-954	55	4	by	by	ADP
mkg-954	55	5	epithelial	epithelial	ADJ
mkg-954	55	6	signals	signal	NOUN
mkg-954	55	7	,	,	PUNCT
mkg-954	55	8	especially	especially	ADV
mkg-954	55	9	fgf8	fgf8	PROPN
mkg-954	55	10	,	,	PUNCT
mkg-954	55	11	and	and	CCONJ
mkg-954	55	12	it	it	PRON
mkg-954	55	13	apparently	apparently	ADV
mkg-954	55	14	regulates	regulate	VERB
mkg-954	55	15	reciprocal	reciprocal	ADJ
mkg-954	55	16	signalling	signal	VERB
mkg-954	55	17	from	from	ADP
mkg-954	55	18	the	the	DET
mkg-954	55	19	mesenchyme	mesenchyme	NOUN
mkg-954	55	20	.	.	PUNCT
mkg-954	56	1	in	in	ADP
mkg-954	56	2	mice	mouse	NOUN
mkg-954	56	3	with	with	ADP
mkg-954	56	4	hypomorphic	hypomorphic	ADJ
mkg-954	56	5	pax9	pax9	NOUN
mkg-954	56	6	mutations	mutation	NOUN
mkg-954	56	7	,	,	PUNCT
mkg-954	56	8	a	a	DET
mkg-954	56	9	partial	partial	ADJ
mkg-954	56	10	failure	failure	NOUN
mkg-954	56	11	of	of	ADP
mkg-954	56	12	tooth	tooth	NOUN
mkg-954	56	13	development	development	NOUN
mkg-954	56	14	was	be	AUX
mkg-954	56	15	observed	observe	VERB
mkg-954	56	16	,	,	PUNCT
mkg-954	56	17	affecting	affect	VERB
mkg-954	56	18	in	in	ADP
mkg-954	56	19	a	a	DET
mkg-954	56	20	dose	dose	NOUN
mkg-954	56	21	-	-	PUNCT
mkg-954	56	22	dependent	dependent	ADJ
mkg-954	56	23	manner	manner	NOUN
mkg-954	56	24	the	the	DET
mkg-954	56	25	third	third	ADJ
mkg-954	56	26	molars	molar	NOUN
mkg-954	56	27	and	and	CCONJ
mkg-954	56	28	incisors	incisor	NOUN
mkg-954	56	29	and	and	CCONJ
mkg-954	56	30	to	to	ADP
mkg-954	56	31	a	a	DET
mkg-954	56	32	smaller	small	ADJ
mkg-954	56	33	extent	extent	NOUN
mkg-954	56	34	the	the	DET
mkg-954	56	35	other	other	ADJ
mkg-954	56	36	molars	molar	NOUN
mkg-954	56	37	.	.	PUNCT
mkg-954	57	1	the	the	DET
mkg-954	57	2	ameloblast	ameloblast	ADJ
mkg-954	57	3	differentiation	differentiation	NOUN
mkg-954	57	4	and	and	CCONJ
mkg-954	57	5	dentinogenesis	dentinogenesis	NOUN
mkg-954	57	6	were	be	AUX
mkg-954	57	7	also	also	ADV
mkg-954	57	8	affected.10	affected.10	NOUN
mkg-954	57	9	it	it	PRON
mkg-954	57	10	has	have	AUX
mkg-954	57	11	been	be	AUX
mkg-954	57	12	suggested	suggest	VERB
mkg-954	57	13	that	that	SCONJ
mkg-954	57	14	the	the	DET
mkg-954	57	15	key	key	ADJ
mkg-954	57	16	role	role	NOUN
mkg-954	57	17	of	of	ADP
mkg-954	57	18	msx1	msx1	PROPN
mkg-954	57	19	and	and	CCONJ
mkg-954	57	20	pax9	pax9	NOUN
mkg-954	57	21	is	be	AUX
mkg-954	57	22	to	to	PART
mkg-954	57	23	facilitate	facilitate	VERB
mkg-954	57	24	the	the	DET
mkg-954	57	25	bud	bud	NOUN
mkg-954	57	26	to	to	PART
mkg-954	57	27	cap	cap	VERB
mkg-954	57	28	stage	stage	NOUN
mkg-954	57	29	transition	transition	NOUN
mkg-954	57	30	.	.	PUNCT
mkg-954	58	1	there	there	PRON
mkg-954	58	2	is	be	VERB
mkg-954	58	3	signals	signal	NOUN
mkg-954	58	4	emanating	emanate	VERB
mkg-954	58	5	from	from	ADP
mkg-954	58	6	the	the	DET
mkg-954	58	7	epithelium	epithelium	NOUN
mkg-954	58	8	and	and	CCONJ
mkg-954	58	9	mesenchymal	mesenchymal	NOUN
mkg-954	58	10	during	during	ADP
mkg-954	58	11	tooth	tooth	NOUN
mkg-954	58	12	development	development	NOUN
mkg-954	58	13	and	and	CCONJ
mkg-954	58	14	molecular	molecular	ADJ
mkg-954	58	15	regulation	regulation	NOUN
mkg-954	58	16	(	(	PUNCT
mkg-954	58	17	figure	figure	NOUN
mkg-954	58	18	1	1	NUM
mkg-954	58	19	)	)	PUNCT
mkg-954	58	20	.	.	PUNCT
mkg-954	59	1	mesenchymal	mesenchymal	ADJ
mkg-954	59	2	msx1	msx1	NOUN
mkg-954	59	3	expression	expression	NOUN
mkg-954	59	4	is	be	AUX
mkg-954	59	5	initially	initially	ADV
mkg-954	59	6	activated	activate	VERB
mkg-954	59	7	by	by	ADP
mkg-954	59	8	the	the	DET
mkg-954	59	9	epithelial	epithelial	ADJ
mkg-954	59	10	bone	bone	NOUN
mkg-954	59	11	figure	figure	NOUN
mkg-954	59	12	1	1	NUM
mkg-954	59	13	.	.	PUNCT
mkg-954	59	14	tooth	tooth	NOUN
mkg-954	59	15	development	development	NOUN
mkg-954	59	16	and	and	CCONJ
mkg-954	59	17	molecular	molecular	ADJ
mkg-954	59	18	regulation	regulation	NOUN
mkg-954	59	19	.	.	PUNCT
mkg-954	60	1	signals	signal	NOUN
mkg-954	60	2	emanating	emanate	VERB
mkg-954	60	3	from	from	ADP
mkg-954	60	4	the	the	DET
mkg-954	60	5	epithelium	epithelium	NOUN
mkg-954	60	6	are	be	AUX
mkg-954	60	7	shown	show	VERB
mkg-954	60	8	above	above	ADP
mkg-954	60	9	and	and	CCONJ
mkg-954	60	10	signals	signal	NOUN
mkg-954	60	11	from	from	ADP
mkg-954	60	12	the	the	DET
mkg-954	60	13	mesenchyme	mesenchyme	NOUN
mkg-954	60	14	below	below	ADP
mkg-954	60	15	the	the	DET
mkg-954	60	16	scheme.1	scheme.1	ADJ
mkg-954	60	17	143rahayu	143rahayu	PROPN
mkg-954	60	18	:	:	PUNCT
mkg-954	60	19	the	the	DET
mkg-954	60	20	role	role	NOUN
mkg-954	60	21	msx1	msx1	NOUN
mkg-954	60	22	and	and	CCONJ
mkg-954	60	23	pax9	pax9	NOUN
mkg-954	60	24	in	in	ADP
mkg-954	60	25	pathogenetic	pathogenetic	ADJ
mkg-954	60	26	morphogenetic	morphogenetic	ADJ
mkg-954	60	27	protein	protein	NOUN
mkg-954	60	28	4	4	NUM
mkg-954	60	29	(	(	PUNCT
mkg-954	60	30	bmp4	bmp4	NOUN
mkg-954	60	31	)	)	PUNCT
mkg-954	60	32	signal	signal	NOUN
mkg-954	60	33	,	,	PUNCT
mkg-954	60	34	and	and	CCONJ
mkg-954	60	35	needed	need	VERB
mkg-954	60	36	for	for	ADP
mkg-954	60	37	a	a	DET
mkg-954	60	38	reciprocal	reciprocal	ADJ
mkg-954	60	39	bmp4	bmp4	NOUN
mkg-954	60	40	signal	signal	NOUN
mkg-954	60	41	from	from	ADP
mkg-954	60	42	the	the	DET
mkg-954	60	43	mesenchyme	mesenchyme	NOUN
mkg-954	60	44	.	.	PUNCT
mkg-954	61	1	bmp4	bmp4	NOUN
mkg-954	61	2	and	and	CCONJ
mkg-954	61	3	msx1	msx1	PROPN
mkg-954	61	4	thus	thus	ADV
mkg-954	61	5	form	form	VERB
mkg-954	61	6	an	an	DET
mkg-954	61	7	autoregulatory	autoregulatory	ADJ
mkg-954	61	8	loop	loop	NOUN
mkg-954	61	9	.	.	PUNCT
mkg-954	62	1	bmp4	bmp4	NOUN
mkg-954	62	2	signal	signal	NOUN
mkg-954	62	3	to	to	ADP
mkg-954	62	4	the	the	DET
mkg-954	62	5	epithelium	epithelium	NOUN
mkg-954	62	6	is	be	AUX
mkg-954	62	7	crucial	crucial	ADJ
mkg-954	62	8	for	for	ADP
mkg-954	62	9	the	the	DET
mkg-954	62	10	formation	formation	NOUN
mkg-954	62	11	of	of	ADP
mkg-954	62	12	the	the	DET
mkg-954	62	13	epithelial	epithelial	ADJ
mkg-954	62	14	signalling	signal	VERB
mkg-954	62	15	centre	centre	NOUN
mkg-954	62	16	,	,	PUNCT
mkg-954	62	17	the	the	DET
mkg-954	62	18	enamel	enamel	NOUN
mkg-954	62	19	knot	knot	NOUN
mkg-954	62	20	,	,	PUNCT
mkg-954	62	21	and	and	CCONJ
mkg-954	62	22	the	the	DET
mkg-954	62	23	arrest	arrest	NOUN
mkg-954	62	24	of	of	ADP
mkg-954	62	25	the	the	DET
mkg-954	62	26	development	development	NOUN
mkg-954	62	27	in	in	ADP
mkg-954	62	28	msx1	msx1	PROPN
mkg-954	62	29	null	null	ADJ
mkg-954	62	30	mutant	mutant	ADJ
mkg-954	62	31	teeth	tooth	NOUN
mkg-954	62	32	can	can	AUX
mkg-954	62	33	be	be	AUX
mkg-954	62	34	rescued	rescue	VERB
mkg-954	62	35	by	by	ADP
mkg-954	62	36	external	external	ADJ
mkg-954	62	37	bmp4	bmp4	NOUN
mkg-954	62	38	or	or	CCONJ
mkg-954	62	39	transgenically	transgenically	ADV
mkg-954	62	40	activated	activate	VERB
mkg-954	62	41	bmp4	bmp4	NOUN
mkg-954	62	42	expression	expression	NOUN
mkg-954	62	43	.	.	PUNCT
mkg-954	63	1	the	the	DET
mkg-954	63	2	expression	expression	NOUN
mkg-954	63	3	of	of	ADP
mkg-954	63	4	pax9	pax9	NOUN
mkg-954	63	5	is	be	AUX
mkg-954	63	6	apparently	apparently	ADV
mkg-954	63	7	needed	need	VERB
mkg-954	63	8	to	to	PART
mkg-954	63	9	maintain	maintain	VERB
mkg-954	63	10	and	and	CCONJ
mkg-954	63	11	,	,	PUNCT
mkg-954	63	12	by	by	ADP
mkg-954	63	13	the	the	DET
mkg-954	63	14	synergism	synergism	NOUN
mkg-954	63	15	with	with	ADP
mkg-954	63	16	msx1	msx1	PROPN
mkg-954	63	17	,	,	PUNCT
mkg-954	63	18	to	to	PART
mkg-954	63	19	enhance	enhance	VERB
mkg-954	63	20	this	this	DET
mkg-954	63	21	loop	loop	NOUN
mkg-954	63	22	and	and	CCONJ
mkg-954	63	23	also	also	ADV
mkg-954	63	24	needed	need	VERB
mkg-954	63	25	later	later	ADV
mkg-954	63	26	in	in	ADP
mkg-954	63	27	tooth	tooth	NOUN
mkg-954	63	28	development.11	development.11	ADJ
mkg-954	63	29	incidence	incidence	NOUN
mkg-954	63	30	of	of	ADP
mkg-954	63	31	tooth	tooth	NOUN
mkg-954	63	32	agenesis	agenesis	NOUN
mkg-954	63	33	the	the	DET
mkg-954	63	34	partial	partial	ADJ
mkg-954	63	35	absence	absence	NOUN
mkg-954	63	36	of	of	ADP
mkg-954	63	37	dental	dental	ADJ
mkg-954	63	38	germs	germ	NOUN
mkg-954	63	39	is	be	AUX
mkg-954	63	40	a	a	DET
mkg-954	63	41	congenital	congenital	ADJ
mkg-954	63	42	defect	defect	NOUN
mkg-954	63	43	of	of	ADP
mkg-954	63	44	hereditary	hereditary	ADJ
mkg-954	63	45	or	or	CCONJ
mkg-954	63	46	acquired	acquire	VERB
mkg-954	63	47	origins	origin	NOUN
mkg-954	63	48	.	.	PUNCT
mkg-954	64	1	dental	dental	ADJ
mkg-954	64	2	agenesis	agenesis	NOUN
mkg-954	64	3	candental	candental	ADJ
mkg-954	64	4	agenesis	agenesis	NOUN
mkg-954	64	5	can	can	AUX
mkg-954	64	6	be	be	AUX
mkg-954	64	7	defined	define	VERB
mkg-954	64	8	as	as	ADP
mkg-954	64	9	any	any	DET
mkg-954	64	10	situation	situation	NOUN
mkg-954	64	11	in	in	ADP
mkg-954	64	12	which	which	PRON
mkg-954	64	13	one	one	NUM
mkg-954	64	14	or	or	CCONJ
mkg-954	64	15	more	more	ADJ
mkg-954	64	16	teeth	tooth	NOUN
mkg-954	64	17	are	be	AUX
mkg-954	64	18	missing	miss	VERB
mkg-954	64	19	because	because	SCONJ
mkg-954	64	20	they	they	PRON
mkg-954	64	21	have	have	AUX
mkg-954	64	22	never	never	ADV
mkg-954	64	23	formed	form	VERB
mkg-954	64	24	.	.	PUNCT
mkg-954	65	1	this	this	PRON
mkg-954	65	2	can	can	AUX
mkg-954	65	3	also	also	ADV
mkg-954	65	4	be	be	AUX
mkg-954	65	5	called	call	VERB
mkg-954	65	6	oligodontia	oligodontia	ADP
mkg-954	65	7	,	,	PUNCT
mkg-954	65	8	dental	dental	ADJ
mkg-954	65	9	aplasia	aplasia	NOUN
mkg-954	65	10	,	,	PUNCT
mkg-954	65	11	and	and	CCONJ
mkg-954	65	12	congenital	congenital	ADJ
mkg-954	65	13	absence	absence	NOUN
mkg-954	65	14	of	of	ADP
mkg-954	65	15	teeth	tooth	NOUN
mkg-954	65	16	or	or	CCONJ
mkg-954	65	17	hypodontia	hypodontia	PROPN
mkg-954	65	18	.	.	PUNCT
mkg-954	66	1	the	the	DET
mkg-954	66	2	term	term	NOUN
mkg-954	66	3	“	"	PUNCT
mkg-954	66	4	oligodontia	oligodontia	PROPN
mkg-954	66	5	”	"	PUNCT
mkg-954	66	6	is	be	AUX
mkg-954	66	7	usually	usually	ADV
mkg-954	66	8	limited	limit	VERB
mkg-954	66	9	to	to	ADP
mkg-954	66	10	those	those	DET
mkg-954	66	11	cases	case	NOUN
mkg-954	66	12	in	in	ADP
mkg-954	66	13	which	which	PRON
mkg-954	66	14	three	three	NUM
mkg-954	66	15	or	or	CCONJ
mkg-954	66	16	more	more	ADJ
mkg-954	66	17	teeth	tooth	NOUN
mkg-954	66	18	are	be	AUX
mkg-954	66	19	missing	miss	VERB
mkg-954	66	20	;	;	PUNCT
mkg-954	66	21	anodontia	anodontia	PROPN
mkg-954	66	22	is	be	AUX
mkg-954	66	23	the	the	DET
mkg-954	66	24	type	type	NOUN
mkg-954	66	25	of	of	ADP
mkg-954	66	26	agenesis	agenesis	NOUN
mkg-954	66	27	in	in	ADP
mkg-954	66	28	which	which	PRON
mkg-954	66	29	all	all	DET
mkg-954	66	30	the	the	DET
mkg-954	66	31	teeth	tooth	NOUN
mkg-954	66	32	are	be	AUX
mkg-954	66	33	missing	miss	VERB
mkg-954	66	34	.	.	PUNCT
mkg-954	67	1	when	when	SCONJ
mkg-954	67	2	agenesis	agenesis	NOUN
mkg-954	67	3	is	be	AUX
mkg-954	67	4	of	of	ADP
mkg-954	67	5	one	one	NUM
mkg-954	67	6	or	or	CCONJ
mkg-954	67	7	a	a	DET
mkg-954	67	8	few	few	ADJ
mkg-954	67	9	teeth	tooth	NOUN
mkg-954	67	10	,	,	PUNCT
mkg-954	67	11	it	it	PRON
mkg-954	67	12	tends	tend	VERB
mkg-954	67	13	to	to	PART
mkg-954	67	14	be	be	AUX
mkg-954	67	15	present	present	ADJ
mkg-954	67	16	more	more	ADJ
mkg-954	67	17	distally.9,12	distally.9,12	NOUN
mkg-954	67	18	congenital	congenital	ADJ
mkg-954	67	19	agenesis	agenesis	NOUN
mkg-954	67	20	of	of	ADP
mkg-954	67	21	one	one	NUM
mkg-954	67	22	or	or	CCONJ
mkg-954	67	23	more	more	ADV
mkg-954	67	24	permanent	permanent	ADJ
mkg-954	67	25	teeth	tooth	NOUN
mkg-954	67	26	,	,	PUNCT
mkg-954	67	27	also	also	ADV
mkg-954	67	28	known	know	VERB
mkg-954	67	29	as	as	ADP
mkg-954	67	30	hypodontia	hypodontia	PROPN
mkg-954	67	31	,	,	PUNCT
mkg-954	67	32	is	be	AUX
mkg-954	67	33	among	among	ADP
mkg-954	67	34	the	the	DET
mkg-954	67	35	most	most	ADV
mkg-954	67	36	wellrecognized	wellrecognized	ADJ
mkg-954	67	37	morphologic	morphologic	ADJ
mkg-954	67	38	anomalies	anomaly	NOUN
mkg-954	67	39	in	in	ADP
mkg-954	67	40	humans	human	NOUN
mkg-954	67	41	,	,	PUNCT
mkg-954	67	42	and	and	CCONJ
mkg-954	67	43	yet	yet	ADV
mkg-954	67	44	the	the	DET
mkg-954	67	45	etiology	etiology	NOUN
mkg-954	67	46	is	be	AUX
mkg-954	67	47	largely	largely	ADV
mkg-954	67	48	unknown	unknown	ADJ
mkg-954	67	49	(	(	PUNCT
mkg-954	67	50	figure	figure	NOUN
mkg-954	67	51	2	2	NUM
mkg-954	67	52	)	)	PUNCT
mkg-954	67	53	.	.	PUNCT
mkg-954	68	1	oligodontia	oligodontia	PROPN
mkg-954	68	2	has	have	AUX
mkg-954	68	3	been	be	AUX
mkg-954	68	4	defined	define	VERB
mkg-954	68	5	as	as	ADP
mkg-954	68	6	agenesis	agenesis	NOUN
mkg-954	68	7	of	of	ADP
mkg-954	68	8	more	more	ADJ
mkg-954	68	9	than	than	ADP
mkg-954	68	10	6	6	NUM
mkg-954	68	11	permanent	permanent	ADJ
mkg-954	68	12	teeth	tooth	NOUN
mkg-954	68	13	.	.	PUNCT
mkg-954	69	1	in	in	ADP
mkg-954	69	2	caucasians	caucasian	NOUN
mkg-954	69	3	,	,	PUNCT
mkg-954	69	4	tooth	tooth	NOUN
mkg-954	69	5	agenesis	agenesis	NOUN
mkg-954	69	6	most	most	ADV
mkg-954	69	7	commonly	commonly	ADV
mkg-954	69	8	involves	involve	VERB
mkg-954	69	9	third	third	ADJ
mkg-954	69	10	molars	molar	NOUN
mkg-954	69	11	,	,	PUNCT
mkg-954	69	12	with	with	ADP
mkg-954	69	13	from	from	ADP
mkg-954	69	14	10	10	NUM
mkg-954	69	15	to	to	PART
mkg-954	69	16	25	25	NUM
mkg-954	69	17	%	%	NOUN
mkg-954	69	18	of	of	ADP
mkg-954	69	19	the	the	DET
mkg-954	69	20	population	population	NOUN
mkg-954	69	21	affected	affect	VERB
mkg-954	69	22	.	.	PUNCT
mkg-954	70	1	reports	report	NOUN
mkg-954	70	2	on	on	ADP
mkg-954	70	3	the	the	DET
mkg-954	70	4	overall	overall	ADJ
mkg-954	70	5	incidence	incidence	NOUN
mkg-954	70	6	of	of	ADP
mkg-954	70	7	missing	miss	VERB
mkg-954	70	8	permanent	permanent	ADJ
mkg-954	70	9	teeth	tooth	NOUN
mkg-954	70	10	,	,	PUNCT
mkg-954	70	11	excluding	exclude	VERB
mkg-954	70	12	third	third	ADJ
mkg-954	70	13	molars	molar	NOUN
mkg-954	70	14	,	,	PUNCT
mkg-954	70	15	vary	vary	VERB
mkg-954	70	16	substantially	substantially	ADV
mkg-954	70	17	,	,	PUNCT
mkg-954	70	18	from	from	ADP
mkg-954	70	19	2	2	NUM
mkg-954	70	20	%	%	NOUN
mkg-954	70	21	to	to	PART
mkg-954	70	22	10	10	NUM
mkg-954	70	23	%	%	NOUN
mkg-954	70	24	.	.	PUNCT
mkg-954	71	1	in	in	ADP
mkg-954	71	2	caucasians	caucasian	NOUN
mkg-954	71	3	,	,	PUNCT
mkg-954	71	4	approximately	approximately	ADV
mkg-954	71	5	80	80	NUM
mkg-954	71	6	%	%	NOUN
mkg-954	71	7	of	of	ADP
mkg-954	71	8	tooth	tooth	NOUN
mkg-954	71	9	agenesis	agenesis	NOUN
mkg-954	71	10	cases	case	NOUN
mkg-954	71	11	involve	involve	VERB
mkg-954	71	12	only	only	ADV
mkg-954	71	13	one	one	NUM
mkg-954	71	14	or	or	CCONJ
mkg-954	71	15	two	two	NUM
mkg-954	71	16	teeth.9	teeth.9	PROPN
mkg-954	71	17	etiology	etiology	NOUN
mkg-954	71	18	and	and	CCONJ
mkg-954	71	19	pathogenesis	pathogenesis	NOUN
mkg-954	71	20	of	of	ADP
mkg-954	71	21	tooth	tooth	NOUN
mkg-954	71	22	agenesiss	agenesiss	ADJ
mkg-954	71	23	evidence	evidence	NOUN
mkg-954	71	24	supporting	support	VERB
mkg-954	71	25	a	a	DET
mkg-954	71	26	genetic	genetic	ADJ
mkg-954	71	27	etiology	etiology	NOUN
mkg-954	71	28	for	for	ADP
mkg-954	71	29	tooth	tooth	NOUN
mkg-954	71	30	agenesis	agenesis	NOUN
mkg-954	71	31	is	be	AUX
mkg-954	71	32	well	well	ADV
mkg-954	71	33	established	establish	VERB
mkg-954	71	34	reviewed	review	VERB
mkg-954	71	35	.	.	PUNCT
mkg-954	72	1	tooth	tooth	NOUN
mkg-954	72	2	agenesis	agenesis	NOUN
mkg-954	72	3	usually	usually	ADV
mkg-954	72	4	presents	present	VERB
mkg-954	72	5	as	as	ADP
mkg-954	72	6	an	an	DET
mkg-954	72	7	isolated	isolated	ADJ
mkg-954	72	8	anomaly	anomaly	NOUN
mkg-954	72	9	.	.	PUNCT
mkg-954	73	1	however	however	ADV
mkg-954	73	2	,	,	PUNCT
mkg-954	73	3	it	it	PRON
mkg-954	73	4	is	be	AUX
mkg-954	73	5	known	know	VERB
mkg-954	73	6	to	to	PART
mkg-954	73	7	occur	occur	VERB
mkg-954	73	8	in	in	ADP
mkg-954	73	9	association	association	NOUN
mkg-954	73	10	with	with	ADP
mkg-954	73	11	syndromes	syndrome	NOUN
mkg-954	73	12	or	or	CCONJ
mkg-954	73	13	inherited	inherit	VERB
mkg-954	73	14	disorders	disorder	NOUN
mkg-954	73	15	,	,	PUNCT
mkg-954	73	16	many	many	ADJ
mkg-954	73	17	of	of	ADP
mkg-954	73	18	which	which	PRON
mkg-954	73	19	have	have	AUX
mkg-954	73	20	known	know	VERB
mkg-954	73	21	genetic	genetic	ADJ
mkg-954	73	22	defects.13	defects.13	NOUN
mkg-954	73	23	tooth	tooth	NOUN
mkg-954	73	24	agenesis	agenesis	NOUN
mkg-954	73	25	is	be	AUX
mkg-954	73	26	one	one	NUM
mkg-954	73	27	of	of	ADP
mkg-954	73	28	the	the	DET
mkg-954	73	29	most	most	ADJ
mkg-954	73	30	commonooth	commonooth	NOUN
mkg-954	73	31	agenesis	agenesis	NOUN
mkg-954	73	32	is	be	AUX
mkg-954	73	33	one	one	NUM
mkg-954	73	34	of	of	ADP
mkg-954	73	35	the	the	DET
mkg-954	73	36	most	most	ADV
mkg-954	73	37	common	common	ADJ
mkg-954	73	38	developmental	developmental	ADJ
mkg-954	73	39	problems	problem	NOUN
mkg-954	73	40	in	in	ADP
mkg-954	73	41	children	child	NOUN
mkg-954	73	42	.	.	PUNCT
mkg-954	74	1	the	the	DET
mkg-954	74	2	congenital	congenital	ADJ
mkg-954	74	3	absence	absence	NOUN
mkg-954	74	4	of	of	ADP
mkg-954	74	5	teeth	tooth	NOUN
mkg-954	74	6	results	result	NOUN
mkg-954	74	7	from	from	ADP
mkg-954	74	8	disturbances	disturbance	NOUN
mkg-954	74	9	during	during	ADP
mkg-954	74	10	the	the	DET
mkg-954	74	11	initial	initial	ADJ
mkg-954	74	12	stages	stage	NOUN
mkg-954	74	13	of	of	ADP
mkg-954	74	14	tooth	tooth	NOUN
mkg-954	74	15	formation	formation	NOUN
mkg-954	74	16	:	:	PUNCT
mkg-954	74	17	initiation	initiation	NOUN
mkg-954	74	18	and	and	CCONJ
mkg-954	74	19	proliferation	proliferation	NOUN
mkg-954	74	20	.	.	PUNCT
mkg-954	75	1	missing	miss	VERB
mkg-954	75	2	teeth	tooth	NOUN
mkg-954	75	3	may	may	AUX
mkg-954	75	4	occur	occur	VERB
mkg-954	75	5	in	in	ADP
mkg-954	75	6	isolation	isolation	NOUN
mkg-954	75	7	,	,	PUNCT
mkg-954	75	8	or	or	CCONJ
mkg-954	75	9	as	as	ADP
mkg-954	75	10	part	part	NOUN
mkg-954	75	11	of	of	ADP
mkg-954	75	12	a	a	DET
mkg-954	75	13	syndrome	syndrome	NOUN
mkg-954	75	14	.	.	PUNCT
mkg-954	76	1	isolated	isolated	ADJ
mkg-954	76	2	cases	case	NOUN
mkg-954	76	3	of	of	ADP
mkg-954	76	4	missing	miss	VERB
mkg-954	76	5	teeth	tooth	NOUN
mkg-954	76	6	can	can	AUX
mkg-954	76	7	be	be	AUX
mkg-954	76	8	familiar	familiar	ADJ
mkg-954	76	9	or	or	CCONJ
mkg-954	76	10	sporadic	sporadic	ADJ
mkg-954	76	11	in	in	ADP
mkg-954	76	12	nature	nature	NOUN
mkg-954	76	13	.	.	PUNCT
mkg-954	77	1	familiar	familiar	ADJ
mkg-954	77	2	tooth	tooth	NOUN
mkg-954	77	3	agenesis	agenesis	NOUN
mkg-954	77	4	is	be	AUX
mkg-954	77	5	transmitted	transmit	VERB
mkg-954	77	6	as	as	ADP
mkg-954	77	7	an	an	DET
mkg-954	77	8	autosomal	autosomal	ADJ
mkg-954	77	9	dominant	dominant	NOUN
mkg-954	77	10	,	,	PUNCT
mkg-954	77	11	autosomal	autosomal	ADJ
mkg-954	77	12	recessive	recessive	ADJ
mkg-954	77	13	,	,	PUNCT
mkg-954	77	14	or	or	CCONJ
mkg-954	77	15	x	x	X
mkg-954	77	16	-	-	VERB
mkg-954	77	17	linked	link	VERB
mkg-954	77	18	genetic	genetic	ADJ
mkg-954	77	19	condition.9	condition.9	NOUN
mkg-954	77	20	while	while	SCONJ
mkg-954	77	21	several	several	ADJ
mkg-954	77	22	potential	potential	ADJ
mkg-954	77	23	and	and	CCONJ
mkg-954	77	24	verified	verify	VERB
mkg-954	77	25	environmental	environmental	ADJ
mkg-954	77	26	(	(	PUNCT
mkg-954	77	27	post	post	X
mkg-954	77	28	genetic	genetic	ADJ
mkg-954	77	29	)	)	PUNCT
mkg-954	77	30	etiological	etiological	ADJ
mkg-954	77	31	factors	factor	NOUN
mkg-954	77	32	at	at	ADP
mkg-954	77	33	tooth	tooth	NOUN
mkg-954	77	34	agenesis	agenesis	NOUN
mkg-954	77	35	have	have	AUX
mkg-954	77	36	been	be	AUX
mkg-954	77	37	presented	present	VERB
mkg-954	77	38	,	,	PUNCT
mkg-954	77	39	there	there	PRON
mkg-954	77	40	is	be	VERB
mkg-954	77	41	definitive	definitive	ADJ
mkg-954	77	42	proof	proof	NOUN
mkg-954	77	43	that	that	SCONJ
mkg-954	77	44	genetic	genetic	ADJ
mkg-954	77	45	factors	factor	NOUN
mkg-954	77	46	play	play	VERB
mkg-954	77	47	a	a	DET
mkg-954	77	48	major	major	ADJ
mkg-954	77	49	role	role	NOUN
mkg-954	77	50	in	in	ADP
mkg-954	77	51	the	the	DET
mkg-954	77	52	etiology	etiology	NOUN
mkg-954	77	53	.	.	PUNCT
mkg-954	78	1	the	the	DET
mkg-954	78	2	role	role	NOUN
mkg-954	78	3	of	of	ADP
mkg-954	78	4	the	the	DET
mkg-954	78	5	genetic	genetic	ADJ
mkg-954	78	6	factors	factor	NOUN
mkg-954	78	7	was	be	AUX
mkg-954	78	8	suggested	suggest	VERB
mkg-954	78	9	by	by	ADP
mkg-954	78	10	observed	observe	VERB
mkg-954	78	11	familial	familial	ADJ
mkg-954	78	12	occurrence	occurrence	NOUN
mkg-954	78	13	,	,	PUNCT
mkg-954	78	14	prevalence	prevalence	NOUN
mkg-954	78	15	differences	difference	NOUN
mkg-954	78	16	between	between	ADP
mkg-954	78	17	populations	population	NOUN
mkg-954	78	18	,	,	PUNCT
mkg-954	78	19	and	and	CCONJ
mkg-954	78	20	association	association	NOUN
mkg-954	78	21	with	with	ADP
mkg-954	78	22	heritable	heritable	ADJ
mkg-954	78	23	syndromes	syndrome	NOUN
mkg-954	78	24	as	as	ADV
mkg-954	78	25	well	well	ADV
mkg-954	78	26	as	as	ADP
mkg-954	78	27	by	by	ADP
mkg-954	78	28	twin	twin	ADJ
mkg-954	78	29	and	and	CCONJ
mkg-954	78	30	family	family	NOUN
mkg-954	78	31	studies	study	NOUN
mkg-954	78	32	,	,	PUNCT
mkg-954	78	33	but	but	CCONJ
mkg-954	78	34	definitive	definitive	ADJ
mkg-954	78	35	evidence	evidence	NOUN
mkg-954	78	36	has	have	AUX
mkg-954	78	37	been	be	AUX
mkg-954	78	38	acquired	acquire	VERB
mkg-954	78	39	during	during	ADP
mkg-954	78	40	the	the	DET
mkg-954	78	41	molecular	molecular	ADJ
mkg-954	78	42	genetic	genetic	ADJ
mkg-954	78	43	era	era	NOUN
mkg-954	78	44	:	:	PUNCT
mkg-954	78	45	defects	defect	NOUN
mkg-954	78	46	in	in	ADP
mkg-954	78	47	several	several	ADJ
mkg-954	78	48	genes	gene	NOUN
mkg-954	78	49	have	have	AUX
mkg-954	78	50	been	be	AUX
mkg-954	78	51	shown	show	VERB
mkg-954	78	52	to	to	PART
mkg-954	78	53	cause	cause	VERB
mkg-954	78	54	agenesis	agenesis	NOUN
mkg-954	78	55	and	and	CCONJ
mkg-954	78	56	anomalies	anomaly	NOUN
mkg-954	78	57	in	in	ADP
mkg-954	78	58	size	size	NOUN
mkg-954	78	59	and	and	CCONJ
mkg-954	78	60	morphology	morphology	NOUN
mkg-954	78	61	.	.	PUNCT
mkg-954	79	1	tooth	tooth	NOUN
mkg-954	79	2	agenesis	agenesis	NOUN
mkg-954	79	3	and	and	CCONJ
mkg-954	79	4	tooth	tooth	NOUN
mkg-954	79	5	size	size	NOUN
mkg-954	79	6	reductions	reduction	NOUN
mkg-954	79	7	have	have	AUX
mkg-954	79	8	been	be	AUX
mkg-954	79	9	related	relate	VERB
mkg-954	79	10	to	to	PART
mkg-954	79	11	trauma	trauma	VERB
mkg-954	79	12	,	,	PUNCT
mkg-954	79	13	maternal	maternal	ADJ
mkg-954	79	14	systemic	systemic	ADJ
mkg-954	79	15	disease	disease	NOUN
mkg-954	79	16	and	and	CCONJ
mkg-954	79	17	various	various	ADJ
mkg-954	79	18	external	external	ADJ
mkg-954	79	19	factors	factor	NOUN
mkg-954	79	20	.	.	PUNCT
mkg-954	80	1	among	among	ADP
mkg-954	80	2	the	the	DET
mkg-954	80	3	maternal	maternal	ADJ
mkg-954	80	4	systemic	systemic	ADJ
mkg-954	80	5	disease	disease	NOUN
mkg-954	80	6	,	,	PUNCT
mkg-954	80	7	diabetes	diabetes	NOUN
mkg-954	80	8	and	and	CCONJ
mkg-954	80	9	different	different	ADJ
mkg-954	80	10	infections	infection	NOUN
mkg-954	80	11	have	have	AUX
mkg-954	80	12	been	be	AUX
mkg-954	80	13	suggested	suggest	VERB
mkg-954	80	14	.	.	PUNCT
mkg-954	81	1	for	for	ADP
mkg-954	81	2	example	example	NOUN
mkg-954	81	3	,	,	PUNCT
mkg-954	81	4	developmental	developmental	ADJ
mkg-954	81	5	dental	dental	ADJ
mkg-954	81	6	anomalies	anomaly	NOUN
mkg-954	81	7	and	and	CCONJ
mkg-954	81	8	tooth	tooth	NOUN
mkg-954	81	9	size	size	NOUN
mkg-954	81	10	reduction	reduction	NOUN
mkg-954	81	11	have	have	AUX
mkg-954	81	12	been	be	AUX
mkg-954	81	13	described	describe	VERB
mkg-954	81	14	in	in	ADP
mkg-954	81	15	association	association	NOUN
mkg-954	81	16	of	of	ADP
mkg-954	81	17	maternal	maternal	ADJ
mkg-954	81	18	rubella	rubella	NOUN
mkg-954	81	19	infection	infection	NOUN
mkg-954	81	20	during	during	ADP
mkg-954	81	21	pregnancy.14	pregnancy.14	PROPN
mkg-954	81	22	the	the	DET
mkg-954	81	23	pathogenesis	pathogenesis	NOUN
mkg-954	81	24	of	of	ADP
mkg-954	81	25	human	human	ADJ
mkg-954	81	26	tooth	tooth	NOUN
mkg-954	81	27	agenesis	agenesis	NOUN
mkg-954	81	28	is	be	AUX
mkg-954	81	29	perhaps	perhaps	ADV
mkg-954	81	30	best	well	ADV
mkg-954	81	31	understood	understand	VERB
mkg-954	81	32	in	in	ADP
mkg-954	81	33	anhidrotic	anhidrotic	ADJ
mkg-954	81	34	ectodermal	ectodermal	ADJ
mkg-954	81	35	dysplasias	dysplasia	NOUN
mkg-954	81	36	.	.	PUNCT
mkg-954	82	1	in	in	ADP
mkg-954	82	2	this	this	DET
mkg-954	82	3	case	case	NOUN
mkg-954	82	4	the	the	DET
mkg-954	82	5	molecular	molecular	ADJ
mkg-954	82	6	pathogenesis	pathogenesis	NOUN
mkg-954	82	7	and	and	CCONJ
mkg-954	82	8	the	the	DET
mkg-954	82	9	phenotypes	phenotype	NOUN
mkg-954	82	10	in	in	ADP
mkg-954	82	11	human	human	ADJ
mkg-954	82	12	patients	patient	NOUN
mkg-954	82	13	and	and	CCONJ
mkg-954	82	14	mouse	mouse	NOUN
mkg-954	82	15	mutants	mutant	NOUN
mkg-954	82	16	are	be	AUX
mkg-954	82	17	directly	directly	ADV
mkg-954	82	18	comparable	comparable	ADJ
mkg-954	82	19	.	.	PUNCT
mkg-954	83	1	the	the	DET
mkg-954	83	2	gene	gene	NOUN
mkg-954	83	3	defects	defect	NOUN
mkg-954	83	4	in	in	ADP
mkg-954	83	5	anhidrotic	anhidrotic	ADJ
mkg-954	83	6	ectodermal	ectodermal	ADJ
mkg-954	83	7	dysplasia	dysplasia	NOUN
mkg-954	83	8	(	(	PUNCT
mkg-954	83	9	eda	eda	PROPN
mkg-954	83	10	)	)	PUNCT
mkg-954	83	11	,	,	PUNCT
mkg-954	83	12	eda	eda	PROPN
mkg-954	83	13	-	-	PUNCT
mkg-954	83	14	receptor	receptor	NOUN
mkg-954	83	15	(	(	PUNCT
mkg-954	83	16	edar	edar	ADV
mkg-954	83	17	)	)	PUNCT
mkg-954	83	18	,	,	PUNCT
mkg-954	83	19	immunoglobulin	immunoglobulin	NOUN
mkg-954	83	20	k	k	PROPN
mkg-954	83	21	-	-	PROPN
mkg-954	83	22	gamma	gamma	NOUN
mkg-954	83	23	(	(	PUNCT
mkg-954	83	24	ikky	ikky	ADJ
mkg-954	83	25	)	)	PUNCT
mkg-954	83	26	and	and	CCONJ
mkg-954	83	27	their	their	PRON
mkg-954	83	28	mouse	mouse	NOUN
mkg-954	83	29	homologs	homolog	NOUN
mkg-954	83	30	,	,	PUNCT
mkg-954	83	31	i.e.	i.e.	X
mkg-954	83	32	the	the	DET
mkg-954	83	33	signalling	signal	VERB
mkg-954	83	34	ligand	ligand	NOUN
mkg-954	83	35	,	,	PUNCT
mkg-954	83	36	its	its	PRON
mkg-954	83	37	receptor	receptor	NOUN
mkg-954	83	38	and	and	CCONJ
mkg-954	83	39	the	the	DET
mkg-954	83	40	intracellular	intracellular	ADJ
mkg-954	83	41	mediators	mediator	NOUN
mkg-954	83	42	of	of	ADP
mkg-954	83	43	the	the	DET
mkg-954	83	44	signalling	signal	VERB
mkg-954	83	45	,	,	PUNCT
mkg-954	83	46	cause	cause	VERB
mkg-954	83	47	complete	complete	ADJ
mkg-954	83	48	inactivation	inactivation	NOUN
mkg-954	83	49	of	of	ADP
mkg-954	83	50	this	this	DET
mkg-954	83	51	signalling	signal	VERB
mkg-954	83	52	pathway	pathway	NOUN
mkg-954	83	53	.	.	PUNCT
mkg-954	84	1	in	in	ADP
mkg-954	84	2	the	the	DET
mkg-954	84	3	mutant	mutant	ADJ
mkg-954	84	4	mice	mouse	NOUN
mkg-954	84	5	,	,	PUNCT
mkg-954	84	6	incisors	incisor	NOUN
mkg-954	84	7	and	and	CCONJ
mkg-954	84	8	third	third	ADJ
mkg-954	84	9	molars	molar	NOUN
mkg-954	84	10	commonly	commonly	ADV
mkg-954	84	11	fail	fail	VERB
mkg-954	84	12	to	to	PART
mkg-954	84	13	develop	develop	VERB
mkg-954	84	14	and	and	CCONJ
mkg-954	84	15	first	first	ADJ
mkg-954	84	16	molars	molar	NOUN
mkg-954	84	17	are	be	AUX
mkg-954	84	18	hypoplastic	hypoplastic	ADJ
mkg-954	84	19	,	,	PUNCT
mkg-954	84	20	while	while	SCONJ
mkg-954	84	21	in	in	ADP
mkg-954	84	22	the	the	DET
mkg-954	84	23	patients	patient	NOUN
mkg-954	84	24	with	with	ADP
mkg-954	84	25	anhidrotic	anhidrotic	ADJ
mkg-954	84	26	ectodermal	ectodermal	ADJ
mkg-954	84	27	dysplasia	dysplasia	NOUN
mkg-954	84	28	,	,	PUNCT
mkg-954	84	29	both	both	DET
mkg-954	84	30	dentitions	dentition	NOUN
mkg-954	84	31	are	be	AUX
mkg-954	84	32	severely	severely	ADV
mkg-954	84	33	affected	affected	ADJ
mkg-954	84	34	and	and	CCONJ
mkg-954	84	35	tooth	tooth	NOUN
mkg-954	84	36	morphology	morphology	NOUN
mkg-954	84	37	is	be	AUX
mkg-954	84	38	simplified	simplify	VERB
mkg-954	84	39	.	.	PUNCT
mkg-954	85	1	the	the	DET
mkg-954	85	2	phenotypes	phenotype	NOUN
mkg-954	85	3	of	of	ADP
mkg-954	85	4	the	the	DET
mkg-954	85	5	mice	mouse	NOUN
mkg-954	85	6	with	with	ADP
mkg-954	85	7	impairment	impairment	NOUN
mkg-954	85	8	or	or	CCONJ
mkg-954	85	9	over	over	ADP
mkg-954	85	10	expression	expression	NOUN
mkg-954	85	11	of	of	ADP
mkg-954	85	12	eda	eda	PROPN
mkg-954	85	13	signalling	signal	VERB
mkg-954	85	14	suggest	suggest	VERB
mkg-954	85	15	that	that	SCONJ
mkg-954	85	16	early	early	ADJ
mkg-954	85	17	defects	defect	NOUN
mkg-954	85	18	of	of	ADP
mkg-954	85	19	ectodermal	ectodermal	ADJ
mkg-954	85	20	placodes	placode	NOUN
mkg-954	85	21	and	and	CCONJ
mkg-954	85	22	,	,	PUNCT
mkg-954	85	23	in	in	ADP
mkg-954	85	24	teeth	tooth	NOUN
mkg-954	85	25	,	,	PUNCT
mkg-954	85	26	the	the	DET
mkg-954	85	27	enamel	enamel	NOUN
mkg-954	85	28	knots	knot	NOUN
mkg-954	85	29	would	would	AUX
mkg-954	85	30	explain	explain	VERB
mkg-954	85	31	the	the	DET
mkg-954	85	32	ectodermal	ectodermal	ADJ
mkg-954	85	33	defects	defect	NOUN
mkg-954	85	34	in	in	ADP
mkg-954	85	35	human	human	ADJ
mkg-954	85	36	patients	patient	NOUN
mkg-954	85	37	.	.	PUNCT
mkg-954	86	1	thus	thus	ADV
mkg-954	86	2	,	,	PUNCT
mkg-954	86	3	failure	failure	NOUN
mkg-954	86	4	of	of	ADP
mkg-954	86	5	signalling	signal	VERB
mkg-954	86	6	at	at	ADP
mkg-954	86	7	an	an	DET
mkg-954	86	8	early	early	ADJ
mkg-954	86	9	stage	stage	NOUN
mkg-954	86	10	leads	lead	VERB
mkg-954	86	11	to	to	ADP
mkg-954	86	12	anomalies	anomaly	NOUN
mkg-954	86	13	that	that	PRON
mkg-954	86	14	are	be	AUX
mkg-954	86	15	present	present	ADJ
mkg-954	86	16	also	also	ADV
mkg-954	86	17	in	in	ADP
mkg-954	86	18	the	the	DET
mkg-954	86	19	deciduous	deciduous	ADJ
mkg-954	86	20	dentition	dentition	NOUN
mkg-954	86	21	.	.	PUNCT
mkg-954	87	1	on	on	ADP
mkg-954	87	2	the	the	DET
mkg-954	87	3	other	other	ADJ
mkg-954	87	4	hand	hand	NOUN
mkg-954	87	5	,	,	PUNCT
mkg-954	87	6	as	as	SCONJ
mkg-954	87	7	the	the	DET
mkg-954	87	8	mutant	mutant	NOUN
mkg-954	87	9	and	and	CCONJ
mkg-954	87	10	disease	disease	NOUN
mkg-954	87	11	phenotypes	phenotype	NOUN
mkg-954	87	12	are	be	AUX
mkg-954	87	13	caused	cause	VERB
mkg-954	87	14	by	by	ADP
mkg-954	87	15	complete	complete	ADJ
mkg-954	87	16	inactivation	inactivation	NOUN
mkg-954	87	17	of	of	ADP
mkg-954	87	18	the	the	DET
mkg-954	87	19	figure	figure	NOUN
mkg-954	87	20	2	2	NUM
mkg-954	87	21	.	.	PUNCT
mkg-954	88	1	the	the	DET
mkg-954	88	2	case	case	NOUN
mkg-954	88	3	of	of	ADP
mkg-954	88	4	permanent	permanent	ADJ
mkg-954	88	5	teeth	tooth	NOUN
mkg-954	88	6	agenesis	agenesis	NOUN
mkg-954	88	7	at	at	ADP
mkg-954	88	8	17	17	NUM
mkg-954	88	9	th	th	NUM
mkg-954	88	10	year	year	NOUN
mkg-954	88	11	old	old	ADJ
mkg-954	88	12	woman	woman	NOUN
mkg-954	88	13	.	.	PUNCT
mkg-954	89	1	144	144	NUM
mkg-954	89	2	dent	dent	NOUN
mkg-954	89	3	.	.	PUNCT
mkg-954	90	1	j.	j.	PROPN
mkg-954	90	2	(	(	PUNCT
mkg-954	90	3	maj	maj	PROPN
mkg-954	90	4	.	.	PROPN
mkg-954	90	5	ked	ked	PROPN
mkg-954	90	6	.	.	PUNCT
mkg-954	91	1	gigi	gigi	PROPN
mkg-954	91	2	)	)	PUNCT
mkg-954	91	3	,	,	PUNCT
mkg-954	92	1	vol	vol	NOUN
mkg-954	92	2	.	.	PUNCT
mkg-954	93	1	42	42	NUM
mkg-954	93	2	.	.	PUNCT
mkg-954	94	1	no	no	INTJ
mkg-954	94	2	.	.	NOUN
mkg-954	95	1	3	3	NUM
mkg-954	95	2	july	july	PROPN
mkg-954	95	3	–	–	PUNCT
mkg-954	95	4	september	september	PROPN
mkg-954	95	5	2009	2009	NUM
mkg-954	95	6	:	:	PUNCT
mkg-954	95	7	141	141	NUM
mkg-954	95	8	-	-	SYM
mkg-954	95	9	146	146	NUM
mkg-954	95	10	signalling	signal	VERB
mkg-954	95	11	pathway	pathway	NOUN
mkg-954	95	12	,	,	PUNCT
mkg-954	95	13	the	the	DET
mkg-954	95	14	partial	partial	ADJ
mkg-954	95	15	albeit	albeit	SCONJ
mkg-954	95	16	severe	severe	ADJ
mkg-954	95	17	tooth	tooth	NOUN
mkg-954	95	18	agenesis	agenesis	NOUN
mkg-954	95	19	phenotypes	phenotype	NOUN
mkg-954	95	20	suggest	suggest	VERB
mkg-954	95	21	redundancy	redundancy	NOUN
mkg-954	95	22	in	in	ADP
mkg-954	95	23	the	the	DET
mkg-954	95	24	function	function	NOUN
mkg-954	95	25	of	of	ADP
mkg-954	95	26	the	the	DET
mkg-954	95	27	signalling	signal	VERB
mkg-954	95	28	pathways	pathway	NOUN
mkg-954	95	29	,	,	PUNCT
mkg-954	95	30	i.e.	i.e.	X
mkg-954	95	31	that	that	SCONJ
mkg-954	95	32	different	different	ADJ
mkg-954	95	33	signalling	signal	VERB
mkg-954	95	34	pathways	pathway	NOUN
mkg-954	95	35	have	have	VERB
mkg-954	95	36	overlapping	overlap	VERB
mkg-954	95	37	functions	function	NOUN
mkg-954	95	38	.	.	PUNCT
mkg-954	96	1	this	this	DET
mkg-954	96	2	redundancy	redundancy	NOUN
mkg-954	96	3	adds	add	VERB
mkg-954	96	4	a	a	DET
mkg-954	96	5	further	further	ADJ
mkg-954	96	6	element	element	NOUN
mkg-954	96	7	explaining	explain	VERB
mkg-954	96	8	how	how	SCONJ
mkg-954	96	9	different	different	ADJ
mkg-954	96	10	gene	gene	NOUN
mkg-954	96	11	defects	defect	NOUN
mkg-954	96	12	may	may	AUX
mkg-954	96	13	cause	cause	VERB
mkg-954	96	14	partial	partial	ADJ
mkg-954	96	15	agenesis.15	agenesis.15	NOUN
mkg-954	96	16	the	the	DET
mkg-954	96	17	congenital	congenital	ADJ
mkg-954	96	18	absence	absence	NOUN
mkg-954	96	19	of	of	ADP
mkg-954	96	20	teeth	tooth	NOUN
mkg-954	96	21	is	be	AUX
mkg-954	96	22	one	one	NUM
mkg-954	96	23	of	of	ADP
mkg-954	96	24	the	the	DET
mkg-954	96	25	commonest	commonest	NOUN
mkg-954	96	26	developmental	developmental	ADJ
mkg-954	96	27	abnormalities	abnormality	NOUN
mkg-954	96	28	seen	see	VERB
mkg-954	96	29	in	in	ADP
mkg-954	96	30	human	human	ADJ
mkg-954	96	31	populations	population	NOUN
mkg-954	96	32	.	.	PUNCT
mkg-954	97	1	familial	familial	ADJ
mkg-954	97	2	hypodontia	hypodontia	NOUN
mkg-954	97	3	or	or	CCONJ
mkg-954	97	4	oligodontia	oligodontia	ADV
mkg-954	97	5	represents	represent	VERB
mkg-954	97	6	an	an	DET
mkg-954	97	7	absence	absence	NOUN
mkg-954	97	8	of	of	ADP
mkg-954	97	9	varying	vary	VERB
mkg-954	97	10	numbers	number	NOUN
mkg-954	97	11	of	of	ADP
mkg-954	97	12	primary	primary	ADJ
mkg-954	97	13	and/or	and/or	CCONJ
mkg-954	97	14	secondary	secondary	ADJ
mkg-954	97	15	teeth	tooth	NOUN
mkg-954	97	16	as	as	ADP
mkg-954	97	17	an	an	DET
mkg-954	97	18	isolated	isolated	ADJ
mkg-954	97	19	trait	trait	NOUN
mkg-954	97	20	.	.	PUNCT
mkg-954	98	1	while	while	SCONJ
mkg-954	98	2	much	much	ADJ
mkg-954	98	3	progress	progress	NOUN
mkg-954	98	4	has	have	AUX
mkg-954	98	5	been	be	AUX
mkg-954	98	6	made	make	VERB
mkg-954	98	7	in	in	ADP
mkg-954	98	8	understanding	understand	VERB
mkg-954	98	9	the	the	DET
mkg-954	98	10	developmental	developmental	ADJ
mkg-954	98	11	basis	basis	NOUN
mkg-954	98	12	of	of	ADP
mkg-954	98	13	tooth	tooth	NOUN
mkg-954	98	14	formation	formation	NOUN
mkg-954	98	15	,	,	PUNCT
mkg-954	98	16	knowledge	knowledge	NOUN
mkg-954	98	17	of	of	ADP
mkg-954	98	18	the	the	DET
mkg-954	98	19	aetiological	aetiological	ADJ
mkg-954	98	20	basis	basis	NOUN
mkg-954	98	21	of	of	ADP
mkg-954	98	22	inherited	inherit	VERB
mkg-954	98	23	tooth	tooth	NOUN
mkg-954	98	24	loss	loss	NOUN
mkg-954	98	25	remains	remain	VERB
mkg-954	98	26	poor	poor	ADJ
mkg-954	98	27	.	.	PUNCT
mkg-954	99	1	the	the	DET
mkg-954	99	2	study	study	NOUN
mkg-954	99	3	of	of	ADP
mkg-954	99	4	mouse	mouse	NOUN
mkg-954	99	5	genetics	genetic	NOUN
mkg-954	99	6	has	have	AUX
mkg-954	99	7	uncovered	uncover	VERB
mkg-954	99	8	a	a	DET
mkg-954	99	9	large	large	ADJ
mkg-954	99	10	number	number	NOUN
mkg-954	99	11	of	of	ADP
mkg-954	99	12	candidate	candidate	NOUN
mkg-954	99	13	genes	gene	NOUN
mkg-954	99	14	for	for	ADP
mkg-954	99	15	this	this	DET
mkg-954	99	16	condition	condition	NOUN
mkg-954	99	17	,	,	PUNCT
mkg-954	99	18	but	but	CCONJ
mkg-954	99	19	mutations	mutation	NOUN
mkg-954	99	20	in	in	ADP
mkg-954	99	21	only	only	ADV
mkg-954	99	22	three	three	NUM
mkg-954	99	23	have	have	AUX
mkg-954	99	24	been	be	AUX
mkg-954	99	25	identified	identify	VERB
mkg-954	99	26	in	in	ADP
mkg-954	99	27	human	human	ADJ
mkg-954	99	28	pedigrees	pedigree	NOUN
mkg-954	99	29	with	with	ADP
mkg-954	99	30	familial	familial	ADJ
mkg-954	99	31	hypodontia	hypodontia	NOUN
mkg-954	99	32	or	or	CCONJ
mkg-954	99	33	oligodontia	oligodontia	ADP
mkg-954	99	34	:	:	PUNCT
mkg-954	99	35	msx1	msx1	PROPN
mkg-954	99	36	,	,	PUNCT
mkg-954	99	37	pax9	pax9	NOUN
mkg-954	99	38	and	and	CCONJ
mkg-954	99	39	axin2	axin2	NOUN
mkg-954	99	40	.	.	PUNCT
mkg-954	100	1	this	this	PRON
mkg-954	100	2	suggests	suggest	VERB
mkg-954	100	3	that	that	SCONJ
mkg-954	100	4	these	these	DET
mkg-954	100	5	conditions	condition	NOUN
mkg-954	100	6	may	may	AUX
mkg-954	100	7	represent	represent	VERB
mkg-954	100	8	a	a	DET
mkg-954	100	9	more	more	ADV
mkg-954	100	10	complex	complex	ADJ
mkg-954	100	11	multifactorial	multifactorial	ADJ
mkg-954	100	12	trait	trait	NOUN
mkg-954	100	13	,	,	PUNCT
mkg-954	100	14	influenced	influence	VERB
mkg-954	100	15	by	by	ADP
mkg-954	100	16	a	a	DET
mkg-954	100	17	combination	combination	NOUN
mkg-954	100	18	of	of	ADP
mkg-954	100	19	gene	gene	NOUN
mkg-954	100	20	function	function	NOUN
mkg-954	100	21	,	,	PUNCT
mkg-954	100	22	environmental	environmental	ADJ
mkg-954	100	23	interaction	interaction	NOUN
mkg-954	100	24	and	and	CCONJ
mkg-954	100	25	developmental	developmental	ADJ
mkg-954	100	26	timing.16	timing.16	PROPN
mkg-954	100	27	the	the	DET
mkg-954	100	28	most	most	ADV
mkg-954	100	29	compelling	compelling	ADJ
mkg-954	100	30	evidence	evidence	NOUN
mkg-954	100	31	for	for	ADP
mkg-954	100	32	the	the	DET
mkg-954	100	33	genetic	genetic	ADJ
mkg-954	100	34	etiology	etiology	NOUN
mkg-954	100	35	of	of	ADP
mkg-954	100	36	tooth	tooth	NOUN
mkg-954	100	37	agenesis	agenesis	NOUN
mkg-954	100	38	has	have	AUX
mkg-954	100	39	been	be	AUX
mkg-954	100	40	provided	provide	VERB
mkg-954	100	41	by	by	ADP
mkg-954	100	42	the	the	DET
mkg-954	100	43	identification	identification	NOUN
mkg-954	100	44	of	of	ADP
mkg-954	100	45	gene	gene	NOUN
mkg-954	100	46	defects	defect	NOUN
mkg-954	100	47	associated	associate	VERB
mkg-954	100	48	with	with	ADP
mkg-954	100	49	different	different	ADJ
mkg-954	100	50	types	type	NOUN
mkg-954	100	51	of	of	ADP
mkg-954	100	52	tooth	tooth	NOUN
mkg-954	100	53	agenesis	agenesis	NOUN
mkg-954	100	54	.	.	PUNCT
mkg-954	101	1	dominant	dominant	ADJ
mkg-954	101	2	defects	defect	NOUN
mkg-954	101	3	in	in	ADP
mkg-954	101	4	msx1	msx1	PROPN
mkg-954	101	5	,	,	PUNCT
mkg-954	101	6	pax9	pax9	NOUN
mkg-954	101	7	and	and	CCONJ
mkg-954	101	8	axin2	axin2	NOUN
mkg-954	101	9	have	have	AUX
mkg-954	101	10	been	be	AUX
mkg-954	101	11	described	describe	VERB
mkg-954	101	12	in	in	ADP
mkg-954	101	13	families	family	NOUN
mkg-954	101	14	with	with	ADP
mkg-954	101	15	isolated	isolated	ADJ
mkg-954	101	16	severe	severe	ADJ
mkg-954	101	17	tooth	tooth	NOUN
mkg-954	101	18	agenesis	agenesis	NOUN
mkg-954	101	19	.	.	PUNCT
mkg-954	102	1	however	however	ADV
mkg-954	102	2	,	,	PUNCT
mkg-954	102	3	in	in	ADP
mkg-954	102	4	association	association	NOUN
mkg-954	102	5	with	with	ADP
mkg-954	102	6	defects	defect	NOUN
mkg-954	102	7	in	in	ADP
mkg-954	102	8	msx1	msx1	PROPN
mkg-954	102	9	,	,	PUNCT
mkg-954	102	10	nail	nail	NOUN
mkg-954	102	11	dysplasia	dysplasia	NOUN
mkg-954	102	12	and	and	CCONJ
mkg-954	102	13	some	some	DET
mkg-954	102	14	patients	patient	NOUN
mkg-954	102	15	with	with	ADP
mkg-954	102	16	oral	oral	ADJ
mkg-954	102	17	clefts	cleft	NOUN
mkg-954	102	18	have	have	AUX
mkg-954	102	19	each	each	PRON
mkg-954	102	20	been	be	AUX
mkg-954	102	21	described	describe	VERB
mkg-954	102	22	in	in	ADP
mkg-954	102	23	single	single	ADJ
mkg-954	102	24	families	family	NOUN
mkg-954	102	25	.	.	PUNCT
mkg-954	103	1	in	in	ADP
mkg-954	103	2	addition	addition	NOUN
mkg-954	103	3	to	to	ADP
mkg-954	103	4	causing	cause	VERB
mkg-954	103	5	severe	severe	ADJ
mkg-954	103	6	tooth	tooth	NOUN
mkg-954	103	7	agenesis	agenesis	NOUN
mkg-954	103	8	phenotype	phenotype	NOUN
mkg-954	103	9	,	,	PUNCT
mkg-954	103	10	a	a	DET
mkg-954	103	11	defect	defect	NOUN
mkg-954	103	12	in	in	ADP
mkg-954	103	13	axin2	axin2	NOUN
mkg-954	103	14	also	also	ADV
mkg-954	103	15	predisposed	predispose	VERB
mkg-954	103	16	to	to	ADP
mkg-954	103	17	colorectal	colorectal	ADJ
mkg-954	103	18	cancer	cancer	NOUN
mkg-954	103	19	.	.	PUNCT
mkg-954	104	1	recently	recently	ADV
mkg-954	104	2	,	,	PUNCT
mkg-954	104	3	two	two	NUM
mkg-954	104	4	defects	defect	NOUN
mkg-954	104	5	that	that	PRON
mkg-954	104	6	affected	affect	VERB
mkg-954	104	7	only	only	ADJ
mkg-954	104	8	dentition	dentition	NOUN
mkg-954	104	9	were	be	AUX
mkg-954	104	10	also	also	ADV
mkg-954	104	11	described	describe	VERB
mkg-954	104	12	in	in	ADP
mkg-954	104	13	eda	eda	PROPN
mkg-954	104	14	.	.	PUNCT
mkg-954	105	1	all	all	DET
mkg-954	105	2	these	these	DET
mkg-954	105	3	gene	gene	NOUN
mkg-954	105	4	defects	defect	NOUN
mkg-954	105	5	cause	cause	VERB
mkg-954	105	6	severe	severe	ADJ
mkg-954	105	7	types	type	NOUN
mkg-954	105	8	of	of	ADP
mkg-954	105	9	agenesis	agenesis	NOUN
mkg-954	105	10	.	.	PUNCT
mkg-954	106	1	however	however	ADV
mkg-954	106	2	,	,	PUNCT
mkg-954	106	3	evidence	evidence	NOUN
mkg-954	106	4	for	for	ADP
mkg-954	106	5	association	association	NOUN
mkg-954	106	6	of	of	ADP
mkg-954	106	7	specific	specific	ADJ
mkg-954	106	8	intragenic	intragenic	ADJ
mkg-954	106	9	polymorphisms	polymorphism	NOUN
mkg-954	106	10	to	to	ADP
mkg-954	106	11	tooth	tooth	NOUN
mkg-954	106	12	agenesis	agenesis	NOUN
mkg-954	106	13	,	,	PUNCT
mkg-954	106	14	apparently	apparently	ADV
mkg-954	106	15	consisting	consist	VERB
mkg-954	106	16	mostly	mostly	ADV
mkg-954	106	17	of	of	ADP
mkg-954	106	18	common	common	ADJ
mkg-954	106	19	types	type	NOUN
mkg-954	106	20	of	of	ADP
mkg-954	106	21	tooth	tooth	NOUN
mkg-954	106	22	agenesis	agenesis	NOUN
mkg-954	106	23	,	,	PUNCT
mkg-954	106	24	has	have	AUX
mkg-954	106	25	been	be	AUX
mkg-954	106	26	presented	present	VERB
mkg-954	106	27	for	for	ADP
mkg-954	106	28	msx1	msx1	PROPN
mkg-954	106	29	,	,	PUNCT
mkg-954	106	30	pax9	pax9	PROPN
mkg-954	106	31	,	,	PUNCT
mkg-954	106	32	axin2	axin2	PROPN
mkg-954	106	33	,	,	PUNCT
mkg-954	106	34	tgfa	tgfa	PROPN
mkg-954	106	35	,	,	PUNCT
mkg-954	106	36	irf6	irf6	PROPN
mkg-954	106	37	and	and	CCONJ
mkg-954	106	38	fgfr1.17	fgfr1.17	ADJ
mkg-954	106	39	the	the	DET
mkg-954	106	40	role	role	NOUN
mkg-954	106	41	of	of	ADP
mkg-954	106	42	genes	gene	NOUN
mkg-954	106	43	in	in	ADP
mkg-954	106	44	tooth	tooth	NOUN
mkg-954	106	45	agenesis	agenesis	NOUN
mkg-954	106	46	identifying	identify	VERB
mkg-954	106	47	a	a	DET
mkg-954	106	48	hereditary	hereditary	ADJ
mkg-954	106	49	dental	dental	ADJ
mkg-954	106	50	pathology	pathology	NOUN
mkg-954	106	51	and	and	CCONJ
mkg-954	106	52	defining	define	VERB
mkg-954	106	53	its	its	PRON
mkg-954	106	54	unique	unique	ADJ
mkg-954	106	55	characteristics	characteristic	NOUN
mkg-954	106	56	are	be	AUX
mkg-954	106	57	the	the	DET
mkg-954	106	58	first	first	ADJ
mkg-954	106	59	steps	step	NOUN
mkg-954	106	60	toward	toward	ADP
mkg-954	106	61	the	the	DET
mkg-954	106	62	dissection	dissection	NOUN
mkg-954	106	63	of	of	ADP
mkg-954	106	64	its	its	PRON
mkg-954	106	65	genetic	genetic	ADJ
mkg-954	106	66	basis	basis	NOUN
mkg-954	106	67	.	.	PUNCT
mkg-954	107	1	a	a	DET
mkg-954	107	2	thorough	thorough	ADJ
mkg-954	107	3	interview	interview	NOUN
mkg-954	107	4	of	of	ADP
mkg-954	107	5	the	the	DET
mkg-954	107	6	patient	patient	NOUN
mkg-954	107	7	and	and	CCONJ
mkg-954	107	8	his	his	PRON
mkg-954	107	9	or	or	CCONJ
mkg-954	107	10	her	her	PRON
mkg-954	107	11	relatives	relative	NOUN
mkg-954	107	12	is	be	AUX
mkg-954	107	13	the	the	DET
mkg-954	107	14	next	next	ADJ
mkg-954	107	15	step	step	NOUN
mkg-954	107	16	to	to	ADP
mkg-954	107	17	defining	define	VERB
mkg-954	107	18	the	the	DET
mkg-954	107	19	trait	trait	NOUN
mkg-954	107	20	as	as	ADP
mkg-954	107	21	familial	familial	ADJ
mkg-954	107	22	;	;	PUNCT
mkg-954	107	23	if	if	SCONJ
mkg-954	107	24	it	it	PRON
mkg-954	107	25	proves	prove	VERB
mkg-954	107	26	to	to	PART
mkg-954	107	27	be	be	AUX
mkg-954	107	28	so	so	ADV
mkg-954	107	29	,	,	PUNCT
mkg-954	107	30	it	it	PRON
mkg-954	107	31	is	be	AUX
mkg-954	107	32	imperative	imperative	ADJ
mkg-954	107	33	to	to	PART
mkg-954	107	34	define	define	VERB
mkg-954	107	35	the	the	DET
mkg-954	107	36	pattern	pattern	NOUN
mkg-954	107	37	of	of	ADP
mkg-954	107	38	inheritance	inheritance	NOUN
mkg-954	107	39	of	of	ADP
mkg-954	107	40	the	the	DET
mkg-954	107	41	anomaly.18	anomaly.18	PROPN
mkg-954	107	42	in	in	ADP
mkg-954	107	43	this	this	DET
mkg-954	107	44	respect	respect	NOUN
mkg-954	107	45	,	,	PUNCT
mkg-954	107	46	several	several	ADJ
mkg-954	107	47	genes	gene	NOUN
mkg-954	107	48	that	that	PRON
mkg-954	107	49	are	be	AUX
mkg-954	107	50	pivotal	pivotal	ADJ
mkg-954	107	51	inin	inin	ADJ
mkg-954	107	52	this	this	DET
mkg-954	107	53	respect	respect	NOUN
mkg-954	107	54	,	,	PUNCT
mkg-954	107	55	several	several	ADJ
mkg-954	107	56	genes	gene	NOUN
mkg-954	107	57	that	that	PRON
mkg-954	107	58	are	be	AUX
mkg-954	107	59	pivotal	pivotal	ADJ
mkg-954	107	60	in	in	ADP
mkg-954	107	61	initiating	initiate	VERB
mkg-954	107	62	the	the	DET
mkg-954	107	63	development	development	NOUN
mkg-954	107	64	of	of	ADP
mkg-954	107	65	teeth	tooth	NOUN
mkg-954	107	66	have	have	AUX
mkg-954	107	67	been	be	AUX
mkg-954	107	68	subjected	subject	VERB
mkg-954	107	69	to	to	ADP
mkg-954	107	70	intense	intense	ADJ
mkg-954	107	71	study	study	NOUN
mkg-954	107	72	in	in	ADP
mkg-954	107	73	the	the	DET
mkg-954	107	74	past	past	ADJ
mkg-954	107	75	decade	decade	NOUN
mkg-954	107	76	.	.	PUNCT
mkg-954	108	1	mutations	mutation	NOUN
mkg-954	108	2	in	in	ADP
mkg-954	108	3	a	a	DET
mkg-954	108	4	number	number	NOUN
mkg-954	108	5	of	of	ADP
mkg-954	108	6	genes	gene	NOUN
mkg-954	108	7	were	be	AUX
mkg-954	108	8	found	find	VERB
mkg-954	108	9	to	to	PART
mkg-954	108	10	interrupt	interrupt	VERB
mkg-954	108	11	tooth	tooth	NOUN
mkg-954	108	12	development	development	NOUN
mkg-954	108	13	in	in	ADP
mkg-954	108	14	mice	mouse	NOUN
mkg-954	108	15	.	.	PUNCT
mkg-954	109	1	however	however	ADV
mkg-954	109	2	,	,	PUNCT
mkg-954	109	3	to	to	ADP
mkg-954	109	4	date	date	NOUN
mkg-954	109	5	there	there	PRON
mkg-954	109	6	are	be	VERB
mkg-954	109	7	only	only	ADV
mkg-954	109	8	three	three	NUM
mkg-954	109	9	genes	gene	NOUN
mkg-954	109	10	associated	associate	VERB
mkg-954	109	11	with	with	ADP
mkg-954	109	12	the	the	DET
mkg-954	109	13	nonsyndromic	nonsyndromic	ADJ
mkg-954	109	14	form	form	NOUN
mkg-954	109	15	of	of	ADP
mkg-954	109	16	human	human	ADJ
mkg-954	109	17	tooth	tooth	NOUN
mkg-954	109	18	agenesis	agenesis	NOUN
mkg-954	109	19	:	:	PUNCT
mkg-954	109	20	axin2	axin2	PROPN
mkg-954	109	21	,	,	PUNCT
mkg-954	109	22	msx1	msx1	PROPN
mkg-954	109	23	,	,	PUNCT
mkg-954	109	24	and	and	CCONJ
mkg-954	109	25	pax9	pax9	PROPN
mkg-954	109	26	.	.	PUNCT
mkg-954	110	1	among	among	ADP
mkg-954	110	2	them	they	PRON
mkg-954	110	3	,	,	PUNCT
mkg-954	110	4	msx1	msx1	PROPN
mkg-954	110	5	and	and	CCONJ
mkg-954	110	6	pax9	pax9	NOUN
mkg-954	110	7	was	be	AUX
mkg-954	110	8	more	more	ADV
mkg-954	110	9	intensively	intensively	ADV
mkg-954	110	10	studied	study	VERB
mkg-954	110	11	.	.	PUNCT
mkg-954	111	1	recently	recently	ADV
mkg-954	111	2	,	,	PUNCT
mkg-954	111	3	the	the	DET
mkg-954	111	4	general	general	ADJ
mkg-954	111	5	structure	structure	NOUN
mkg-954	111	6	of	of	ADP
mkg-954	111	7	the	the	DET
mkg-954	111	8	pax	pax	ADJ
mkg-954	111	9	paired	pair	VERB
mkg-954	111	10	domain	domain	NOUN
mkg-954	111	11	was	be	AUX
mkg-954	111	12	described	describe	VERB
mkg-954	111	13	and	and	CCONJ
mkg-954	111	14	the	the	DET
mkg-954	111	15	phylogenetics	phylogenetic	NOUN
mkg-954	111	16	and	and	CCONJ
mkg-954	111	17	relation	relation	NOUN
mkg-954	111	18	between	between	ADP
mkg-954	111	19	the	the	DET
mkg-954	111	20	several	several	ADJ
mkg-954	111	21	members	member	NOUN
mkg-954	111	22	of	of	ADP
mkg-954	111	23	the	the	DET
mkg-954	111	24	pax	pax	PROPN
mkg-954	111	25	family	family	NOUN
mkg-954	111	26	were	be	AUX
mkg-954	111	27	established	establish	VERB
mkg-954	111	28	.	.	PUNCT
mkg-954	112	1	in	in	ADP
mkg-954	112	2	addition	addition	NOUN
mkg-954	112	3	,	,	PUNCT
mkg-954	112	4	both	both	DET
mkg-954	112	5	gene	gene	NOUN
mkg-954	112	6	expression	expression	NOUN
mkg-954	112	7	and	and	CCONJ
mkg-954	112	8	molecular	molecular	ADJ
mkg-954	112	9	pathogenesis	pathogenesis	NOUN
mkg-954	112	10	of	of	ADP
mkg-954	112	11	msx1	msx1	PROPN
mkg-954	112	12	and	and	CCONJ
mkg-954	112	13	pax9	pax9	NOUN
mkg-954	112	14	have	have	AUX
mkg-954	112	15	been	be	AUX
mkg-954	112	16	relatively	relatively	ADV
mkg-954	112	17	well	well	ADV
mkg-954	112	18	characterized	characterize	VERB
mkg-954	112	19	,	,	PUNCT
mkg-954	112	20	making	make	VERB
mkg-954	112	21	it	it	PRON
mkg-954	112	22	a	a	DET
mkg-954	112	23	special	special	ADJ
mkg-954	112	24	candidate	candidate	NOUN
mkg-954	112	25	to	to	PART
mkg-954	112	26	explain	explain	VERB
mkg-954	112	27	at	at	ADP
mkg-954	112	28	least	least	ADJ
mkg-954	112	29	part	part	NOUN
mkg-954	112	30	of	of	ADP
mkg-954	112	31	primate	primate	ADJ
mkg-954	112	32	tooth	tooth	NOUN
mkg-954	112	33	variation	variation	NOUN
mkg-954	112	34	(	(	PUNCT
mkg-954	112	35	figure	figure	NOUN
mkg-954	112	36	3).19	3).19	NUM
mkg-954	112	37	figure	figure	NOUN
mkg-954	112	38	3	3	NUM
mkg-954	112	39	.	.	PUNCT
mkg-954	113	1	the	the	DET
mkg-954	113	2	mutation	mutation	NOUN
mkg-954	113	3	of	of	ADP
mkg-954	113	4	two	two	NUM
mkg-954	113	5	genes	gene	NOUN
mkg-954	113	6	tooth	tooth	NOUN
mkg-954	113	7	development	development	NOUN
mkg-954	113	8	(	(	PUNCT
mkg-954	113	9	msx1	msx1	PROPN
mkg-954	113	10	and	and	CCONJ
mkg-954	113	11	pax9	pax9	PROPN
mkg-954	113	12	)	)	PUNCT
mkg-954	113	13	which	which	PRON
mkg-954	113	14	can	can	AUX
mkg-954	113	15	lead	lead	VERB
mkg-954	113	16	to	to	ADP
mkg-954	113	17	tooth	tooth	NOUN
mkg-954	113	18	agenesis	agenesis	NOUN
mkg-954	113	19	.	.	PUNCT
mkg-954	114	1	darkness	darkness	NOUN
mkg-954	114	2	of	of	ADP
mkg-954	114	3	the	the	DET
mkg-954	114	4	colour	colour	NOUN
mkg-954	114	5	expresses	express	VERB
mkg-954	114	6	the	the	DET
mkg-954	114	7	frequency	frequency	NOUN
mkg-954	114	8	of	of	ADP
mkg-954	114	9	agenesis.19	agenesis.19	NOUN
mkg-954	114	10	discussion	discussion	NOUN
mkg-954	114	11	there	there	PRON
mkg-954	114	12	is	be	VERB
mkg-954	114	13	considerable	considerable	ADJ
mkg-954	114	14	evidence	evidence	NOUN
mkg-954	114	15	suggesting	suggest	VERB
mkg-954	114	16	that	that	SCONJ
mkg-954	114	17	genes	gene	NOUN
mkg-954	114	18	play	play	VERB
mkg-954	114	19	a	a	DET
mkg-954	114	20	fundamental	fundamental	ADJ
mkg-954	114	21	role	role	NOUN
mkg-954	114	22	in	in	ADP
mkg-954	114	23	the	the	DET
mkg-954	114	24	etiology	etiology	NOUN
mkg-954	114	25	of	of	ADP
mkg-954	114	26	tooth	tooth	NOUN
mkg-954	114	27	agenesis	agenesis	NOUN
mkg-954	114	28	.	.	PUNCT
mkg-954	115	1	moreover	moreover	ADV
mkg-954	115	2	,	,	PUNCT
mkg-954	115	3	there	there	PRON
mkg-954	115	4	seems	seem	VERB
mkg-954	115	5	to	to	PART
mkg-954	115	6	be	be	AUX
mkg-954	115	7	a	a	DET
mkg-954	115	8	genetic	genetic	ADJ
mkg-954	115	9	relationship	relationship	NOUN
mkg-954	115	10	in	in	ADP
mkg-954	115	11	the	the	DET
mkg-954	115	12	determination	determination	NOUN
mkg-954	115	13	of	of	ADP
mkg-954	115	14	different	different	ADJ
mkg-954	115	15	dental	dental	ADJ
mkg-954	115	16	anomalies	anomaly	NOUN
mkg-954	115	17	,	,	PUNCT
mkg-954	115	18	considering	consider	VERB
mkg-954	115	19	the	the	DET
mkg-954	115	20	high	high	ADJ
mkg-954	115	21	frequency	frequency	NOUN
mkg-954	115	22	of	of	ADP
mkg-954	115	23	patterns	pattern	NOUN
mkg-954	115	24	of	of	ADP
mkg-954	115	25	association	association	NOUN
mkg-954	115	26	.	.	PUNCT
mkg-954	116	1	a	a	DET
mkg-954	116	2	single	single	ADJ
mkg-954	116	3	genetic	genetic	ADJ
mkg-954	116	4	defect	defect	NOUN
mkg-954	116	5	may	may	AUX
mkg-954	116	6	result	result	VERB
mkg-954	116	7	in	in	ADP
mkg-954	116	8	different	different	ADJ
mkg-954	116	9	phenotypic	phenotypic	ADJ
mkg-954	116	10	expressions	expression	NOUN
mkg-954	116	11	,	,	PUNCT
mkg-954	116	12	including	include	VERB
mkg-954	116	13	such	such	ADJ
mkg-954	116	14	various	various	ADJ
mkg-954	116	15	traits	trait	NOUN
mkg-954	116	16	as	as	ADP
mkg-954	116	17	tooth	tooth	NOUN
mkg-954	116	18	agenesis	agenesis	NOUN
mkg-954	116	19	,	,	PUNCT
mkg-954	116	20	microdontia	microdontia	NOUN
mkg-954	116	21	,	,	PUNCT
mkg-954	116	22	ectopic	ectopic	ADJ
mkg-954	116	23	tooth	tooth	NOUN
mkg-954	116	24	position	position	NOUN
mkg-954	116	25	,	,	PUNCT
mkg-954	116	26	and	and	CCONJ
mkg-954	116	27	delayed	delay	VERB
mkg-954	116	28	development	development	NOUN
mkg-954	116	29	of	of	ADP
mkg-954	116	30	different	different	ADJ
mkg-954	116	31	teeth	tooth	NOUN
mkg-954	116	32	.	.	PUNCT
mkg-954	117	1	as	as	ADP
mkg-954	117	2	with	with	ADP
mkg-954	117	3	many	many	ADJ
mkg-954	117	4	other	other	ADJ
mkg-954	117	5	organs	organ	NOUN
mkg-954	117	6	,	,	PUNCT
mkg-954	117	7	tooth	tooth	NOUN
mkg-954	117	8	development	development	NOUN
mkg-954	117	9	involves	involve	VERB
mkg-954	117	10	sequential	sequential	ADJ
mkg-954	117	11	and	and	CCONJ
mkg-954	117	12	reciprocal	reciprocal	ADJ
mkg-954	117	13	signalling	signalling	NOUN
mkg-954	117	14	processes	process	NOUN
mkg-954	117	15	between	between	ADP
mkg-954	117	16	epithelial	epithelial	ADJ
mkg-954	117	17	and	and	CCONJ
mkg-954	117	18	mesenchymal	mesenchymal	ADJ
mkg-954	117	19	cell	cell	NOUN
mkg-954	117	20	layers	layer	NOUN
mkg-954	117	21	that	that	PRON
mkg-954	117	22	are	be	AUX
mkg-954	117	23	orchestrated	orchestrate	VERB
mkg-954	117	24	by	by	ADP
mkg-954	117	25	a	a	DET
mkg-954	117	26	hierarchy	hierarchy	NOUN
mkg-954	117	27	of	of	ADP
mkg-954	117	28	genes	gene	NOUN
mkg-954	117	29	encoding	encode	VERB
mkg-954	117	30	secreted	secrete	VERB
mkg-954	117	31	growth	growth	NOUN
mkg-954	117	32	factors	factor	NOUN
mkg-954	117	33	,	,	PUNCT
mkg-954	117	34	extra	extra	ADJ
mkg-954	117	35	cellular	cellular	ADJ
mkg-954	117	36	matrix	matrix	NOUN
mkg-954	117	37	components	component	NOUN
mkg-954	117	38	,	,	PUNCT
mkg-954	117	39	and	and	CCONJ
mkg-954	117	40	transcriptional	transcriptional	ADJ
mkg-954	117	41	regulators	regulator	NOUN
mkg-954	117	42	.	.	PUNCT
mkg-954	118	1	because	because	SCONJ
mkg-954	118	2	the	the	DET
mkg-954	118	3	regulatory	regulatory	ADJ
mkg-954	118	4	genes	gene	NOUN
mkg-954	118	5	required	require	VERB
mkg-954	118	6	for	for	ADP
mkg-954	118	7	tooth	tooth	NOUN
mkg-954	118	8	formation	formation	NOUN
mkg-954	118	9	are	be	AUX
mkg-954	118	10	common	common	ADJ
mkg-954	118	11	components	component	NOUN
mkg-954	118	12	of	of	ADP
mkg-954	118	13	signalling	signal	VERB
mkg-954	118	14	cascades	cascade	NOUN
mkg-954	118	15	involved	involve	VERB
mkg-954	118	16	in	in	ADP
mkg-954	118	17	development	development	NOUN
mkg-954	118	18	of	of	ADP
mkg-954	118	19	other	other	ADJ
mkg-954	118	20	embryonic	embryonic	ADJ
mkg-954	118	21	structures	structure	NOUN
mkg-954	118	22	.	.	PUNCT
mkg-954	119	1	among	among	ADP
mkg-954	119	2	the	the	DET
mkg-954	119	3	transcriptional	transcriptional	ADJ
mkg-954	119	4	regulatory	regulatory	ADJ
mkg-954	119	5	genes	gene	NOUN
mkg-954	119	6	required	require	VERB
mkg-954	119	7	for	for	ADP
mkg-954	119	8	tooth	tooth	NOUN
mkg-954	119	9	formation	formation	NOUN
mkg-954	119	10	,	,	PUNCT
mkg-954	119	11	the	the	DET
mkg-954	119	12	msx1	msx1	PROPN
mkg-954	119	13	homeobox	homeobox	PROPN
mkg-954	119	14	gene	gene	NOUN
mkg-954	119	15	is	be	AUX
mkg-954	119	16	highly	highly	ADV
mkg-954	119	17	expressed	express	VERB
mkg-954	119	18	in	in	ADP
mkg-954	119	19	the	the	DET
mkg-954	119	20	dental	dental	ADJ
mkg-954	119	21	mesenchyme	mesenchyme	NOUN
mkg-954	119	22	and	and	CCONJ
mkg-954	119	23	is	be	AUX
mkg-954	119	24	essential	essential	ADJ
mkg-954	119	25	for	for	ADP
mkg-954	119	26	tooth	tooth	NOUN
mkg-954	119	27	development	development	NOUN
mkg-954	119	28	,	,	PUNCT
mkg-954	119	29	since	since	SCONJ
mkg-954	119	30	targeted	target	VERB
mkg-954	119	31	gene	gene	NOUN
mkg-954	119	32	disruption	disruption	NOUN
mkg-954	119	33	results	result	NOUN
mkg-954	119	34	in	in	ADP
mkg-954	119	35	arrested	arrest	VERB
mkg-954	119	36	tooth	tooth	NOUN
mkg-954	119	37	formation	formation	NOUN
mkg-954	119	38	at	at	ADP
mkg-954	119	39	an	an	DET
mkg-954	119	40	early	early	ADJ
mkg-954	119	41	stage	stage	NOUN
mkg-954	119	42	in	in	ADP
mkg-954	119	43	msx1	msx1	PROPN
mkg-954	119	44	.	.	PUNCT
mkg-954	120	1	in	in	ADP
mkg-954	120	2	addition	addition	NOUN
mkg-954	120	3	to	to	ADP
mkg-954	120	4	its	its	PRON
mkg-954	120	5	expression	expression	NOUN
mkg-954	120	6	in	in	ADP
mkg-954	120	7	the	the	DET
mkg-954	120	8	tooth	tooth	NOUN
mkg-954	120	9	primordia	primordium	NOUN
mkg-954	120	10	,	,	PUNCT
mkg-954	120	11	msx1	msx1	ADJ
mkg-954	120	12	expression	expression	NOUN
mkg-954	120	13	is	be	AUX
mkg-954	120	14	prominent	prominent	ADJ
mkg-954	120	15	in	in	ADP
mkg-954	120	16	regions	region	NOUN
mkg-954	120	17	of	of	ADP
mkg-954	120	18	epithelialmesenchymal	epithelialmesenchymal	ADJ
mkg-954	120	19	interactions	interaction	NOUN
mkg-954	120	20	in	in	ADP
mkg-954	120	21	several	several	ADJ
mkg-954	120	22	other	other	ADJ
mkg-954	120	23	embryonic	embryonic	ADJ
mkg-954	120	24	structures	structure	NOUN
mkg-954	120	25	,	,	PUNCT
mkg-954	120	26	including	include	VERB
mkg-954	120	27	other	other	ADJ
mkg-954	120	28	craniofacial	craniofacial	ADJ
mkg-954	120	29	structures	structure	NOUN
mkg-954	120	30	and	and	CCONJ
mkg-954	120	31	the	the	DET
mkg-954	120	32	limb	limb	NOUN
mkg-954	120	33	.	.	PUNCT
mkg-954	121	1	these	these	DET
mkg-954	121	2	findings	finding	NOUN
mkg-954	121	3	have	have	AUX
mkg-954	121	4	led	lead	VERB
mkg-954	121	5	to	to	ADP
mkg-954	121	6	the	the	DET
mkg-954	121	7	hypothesis	hypothesis	NOUN
mkg-954	121	8	that	that	PRON
mkg-954	121	9	msx1	msx1	PROPN
mkg-954	121	10	is	be	AUX
mkg-954	121	11	an	an	DET
mkg-954	121	12	important	important	ADJ
mkg-954	121	13	component	component	NOUN
mkg-954	121	14	in	in	ADP
mkg-954	121	15	the	the	DET
mkg-954	121	16	signalling	signal	VERB
mkg-954	121	17	events	event	NOUN
mkg-954	121	18	that	that	PRON
mkg-954	121	19	occur	occur	VERB
mkg-954	121	20	between	between	ADP
mkg-954	121	21	epithelial	epithelial	ADJ
mkg-954	121	22	and	and	CCONJ
mkg-954	121	23	mesenchymal	mesenchymal	ADJ
mkg-954	121	24	tissues.19	tissues.19	NOUN
mkg-954	121	25	145rahayu	145rahayu	PROPN
mkg-954	121	26	:	:	PUNCT
mkg-954	121	27	the	the	DET
mkg-954	121	28	role	role	NOUN
mkg-954	121	29	msx1	msx1	NOUN
mkg-954	121	30	and	and	CCONJ
mkg-954	121	31	pax9	pax9	NOUN
mkg-954	121	32	in	in	ADP
mkg-954	121	33	pathogenetic	pathogenetic	ADJ
mkg-954	121	34	both	both	CCONJ
mkg-954	121	35	msx1	msx1	PROPN
mkg-954	121	36	and	and	CCONJ
mkg-954	121	37	pax9	pax9	NOUN
mkg-954	121	38	are	be	AUX
mkg-954	121	39	also	also	ADV
mkg-954	121	40	needed	need	VERB
mkg-954	121	41	for	for	ADP
mkg-954	121	42	the	the	DET
mkg-954	121	43	mesenchymal	mesenchymal	NOUN
mkg-954	121	44	cell	cell	NOUN
mkg-954	121	45	condensation	condensation	NOUN
mkg-954	121	46	around	around	ADP
mkg-954	121	47	the	the	DET
mkg-954	121	48	growing	grow	VERB
mkg-954	121	49	epithelial	epithelial	ADJ
mkg-954	121	50	bud	bud	NOUN
mkg-954	121	51	.	.	PUNCT
mkg-954	122	1	the	the	DET
mkg-954	122	2	reduced	reduce	VERB
mkg-954	122	3	condensation	condensation	NOUN
mkg-954	122	4	which	which	PRON
mkg-954	122	5	is	be	AUX
mkg-954	122	6	also	also	ADV
mkg-954	122	7	seen	see	VERB
mkg-954	122	8	in	in	ADP
mkg-954	122	9	the	the	DET
mkg-954	122	10	pax9	pax9	NOUN
mkg-954	122	11	hypomorphic	hypomorphic	ADJ
mkg-954	122	12	mutans	mutan	NOUN
mkg-954	122	13	,	,	PUNCT
mkg-954	122	14	perhaps	perhaps	ADV
mkg-954	122	15	indicating	indicate	VERB
mkg-954	122	16	a	a	DET
mkg-954	122	17	decreased	decrease	VERB
mkg-954	122	18	amount	amount	NOUN
mkg-954	122	19	of	of	ADP
mkg-954	122	20	committed	commit	VERB
mkg-954	122	21	dental	dental	ADJ
mkg-954	122	22	mesenchymal	mesenchymal	NOUN
mkg-954	122	23	cells	cell	NOUN
mkg-954	122	24	,	,	PUNCT
mkg-954	122	25	may	may	AUX
mkg-954	122	26	be	be	AUX
mkg-954	122	27	related	relate	VERB
mkg-954	122	28	to	to	ADP
mkg-954	122	29	tooth	tooth	NOUN
mkg-954	122	30	agenesis	agenesis	NOUN
mkg-954	122	31	.	.	PUNCT
mkg-954	123	1	as	as	SCONJ
mkg-954	123	2	msx1	msx1	PROPN
mkg-954	123	3	is	be	AUX
mkg-954	123	4	known	know	VERB
mkg-954	123	5	to	to	PART
mkg-954	123	6	be	be	AUX
mkg-954	123	7	important	important	ADJ
mkg-954	123	8	for	for	ADP
mkg-954	123	9	the	the	DET
mkg-954	123	10	commitment	commitment	NOUN
mkg-954	123	11	of	of	ADP
mkg-954	123	12	neural	neural	ADJ
mkg-954	123	13	crest	crest	NOUN
mkg-954	123	14	,	,	PUNCT
mkg-954	123	15	an	an	DET
mkg-954	123	16	early	early	ADJ
mkg-954	123	17	defect	defect	NOUN
mkg-954	123	18	in	in	ADP
mkg-954	123	19	the	the	DET
mkg-954	123	20	migration	migration	NOUN
mkg-954	123	21	of	of	ADP
mkg-954	123	22	neural	neural	ADJ
mkg-954	123	23	crest	crest	NOUN
mkg-954	123	24	cells	cell	NOUN
mkg-954	123	25	could	could	AUX
mkg-954	123	26	also	also	ADV
mkg-954	123	27	be	be	AUX
mkg-954	123	28	responsible	responsible	ADJ
mkg-954	123	29	for	for	ADP
mkg-954	123	30	the	the	DET
mkg-954	123	31	tooth	tooth	NOUN
mkg-954	123	32	agenesis	agenesis	NOUN
mkg-954	123	33	,	,	PUNCT
mkg-954	123	34	if	if	SCONJ
mkg-954	123	35	it	it	PRON
mkg-954	123	36	caused	cause	VERB
mkg-954	123	37	a	a	DET
mkg-954	123	38	reduction	reduction	NOUN
mkg-954	123	39	in	in	ADP
mkg-954	123	40	the	the	DET
mkg-954	123	41	amount	amount	NOUN
mkg-954	123	42	of	of	ADP
mkg-954	123	43	competent	competent	ADJ
mkg-954	123	44	ectomesenchymal	ectomesenchymal	ADJ
mkg-954	123	45	cells.20	cells.20	NOUN
mkg-954	123	46	one	one	NUM
mkg-954	123	47	of	of	ADP
mkg-954	123	48	the	the	DET
mkg-954	123	49	earliest	early	ADJ
mkg-954	123	50	placodal	placodal	ADJ
mkg-954	123	51	markers	marker	NOUN
mkg-954	123	52	,	,	PUNCT
mkg-954	123	53	edar	edar	ADV
mkg-954	123	54	,	,	PUNCT
mkg-954	123	55	is	be	AUX
mkg-954	123	56	originally	originally	ADV
mkg-954	123	57	expressed	express	VERB
mkg-954	123	58	throughout	throughout	ADP
mkg-954	123	59	the	the	DET
mkg-954	123	60	oral	oral	ADJ
mkg-954	123	61	epithelium	epithelium	NOUN
mkg-954	123	62	and	and	CCONJ
mkg-954	123	63	epidermis	epidermis	NOUN
mkg-954	123	64	,	,	PUNCT
mkg-954	123	65	but	but	CCONJ
mkg-954	123	66	becomes	become	VERB
mkg-954	123	67	limited	limit	VERB
mkg-954	123	68	to	to	ADP
mkg-954	123	69	the	the	DET
mkg-954	123	70	placodes	placode	NOUN
mkg-954	123	71	at	at	ADP
mkg-954	123	72	an	an	DET
mkg-954	123	73	early	early	ADJ
mkg-954	123	74	stage	stage	NOUN
mkg-954	123	75	.	.	PUNCT
mkg-954	124	1	when	when	SCONJ
mkg-954	124	2	eda	eda	PROPN
mkg-954	124	3	was	be	AUX
mkg-954	124	4	over	over	ADV
mkg-954	124	5	expressed	express	VERB
mkg-954	124	6	in	in	ADP
mkg-954	124	7	the	the	DET
mkg-954	124	8	epithelium	epithelium	NOUN
mkg-954	124	9	,	,	PUNCT
mkg-954	124	10	the	the	DET
mkg-954	124	11	hair	hair	NOUN
mkg-954	124	12	and	and	CCONJ
mkg-954	124	13	tooth	tooth	NOUN
mkg-954	124	14	placodes	placode	NOUN
mkg-954	124	15	become	become	VERB
mkg-954	124	16	larger	large	ADJ
mkg-954	124	17	,	,	PUNCT
mkg-954	124	18	probably	probably	ADV
mkg-954	124	19	due	due	ADP
mkg-954	124	20	to	to	ADP
mkg-954	124	21	an	an	DET
mkg-954	124	22	increased	increase	VERB
mkg-954	124	23	amount	amount	NOUN
mkg-954	124	24	of	of	ADP
mkg-954	124	25	the	the	DET
mkg-954	124	26	cells	cell	NOUN
mkg-954	124	27	destined	destine	VERB
mkg-954	124	28	to	to	PART
mkg-954	124	29	become	become	VERB
mkg-954	124	30	placode	placode	NOUN
mkg-954	124	31	cells	cell	NOUN
mkg-954	124	32	.	.	PUNCT
mkg-954	125	1	thus	thus	ADV
mkg-954	125	2	eda	eda	PROPN
mkg-954	125	3	signalling	signal	VERB
mkg-954	125	4	probably	probably	ADV
mkg-954	125	5	acts	act	VERB
mkg-954	125	6	rather	rather	ADV
mkg-954	125	7	as	as	ADP
mkg-954	125	8	a	a	DET
mkg-954	125	9	modulator	modulator	NOUN
mkg-954	125	10	of	of	ADP
mkg-954	125	11	ectodermal	ectodermal	ADJ
mkg-954	125	12	placodeformation	placodeformation	NOUN
mkg-954	125	13	than	than	ADP
mkg-954	125	14	as	as	ADP
mkg-954	125	15	an	an	DET
mkg-954	125	16	initiator	initiator	NOUN
mkg-954	125	17	.	.	PUNCT
mkg-954	126	1	eda	eda	PROPN
mkg-954	126	2	signalling	signal	VERB
mkg-954	126	3	may	may	AUX
mkg-954	126	4	be	be	AUX
mkg-954	126	5	important	important	ADJ
mkg-954	126	6	as	as	ADP
mkg-954	126	7	a	a	DET
mkg-954	126	8	mediator	mediator	NOUN
mkg-954	126	9	of	of	ADP
mkg-954	126	10	effects	effect	NOUN
mkg-954	126	11	of	of	ADP
mkg-954	126	12	shh	shh	NOUN
mkg-954	126	13	and	and	CCONJ
mkg-954	126	14	bmps	bmp	NOUN
mkg-954	126	15	.	.	PUNCT
mkg-954	127	1	mutation	mutation	NOUN
mkg-954	127	2	in	in	ADP
mkg-954	127	3	the	the	DET
mkg-954	127	4	eda	eda	PROPN
mkg-954	127	5	and	and	CCONJ
mkg-954	127	6	edar	edar	ADV
mkg-954	127	7	genes	gene	NOUN
mkg-954	127	8	in	in	ADP
mkg-954	127	9	human	human	ADJ
mkg-954	127	10	cause	cause	NOUN
mkg-954	127	11	x	x	VERB
mkg-954	127	12	-	-	VERB
mkg-954	127	13	linked	link	VERB
mkg-954	127	14	and	and	CCONJ
mkg-954	127	15	autosomal	autosomal	ADJ
mkg-954	127	16	anhidrotic	anhidrotic	ADJ
mkg-954	127	17	ectodermal	ectodermal	ADJ
mkg-954	127	18	dysplasia	dysplasia	NOUN
mkg-954	127	19	characterized	characterize	VERB
mkg-954	127	20	by	by	ADP
mkg-954	127	21	failure	failure	NOUN
mkg-954	127	22	of	of	ADP
mkg-954	127	23	sweat	sweat	NOUN
mkg-954	127	24	development	development	NOUN
mkg-954	127	25	,	,	PUNCT
mkg-954	127	26	tooth	tooth	NOUN
mkg-954	127	27	agenesis	agenesis	NOUN
mkg-954	127	28	and	and	CCONJ
mkg-954	127	29	size	size	NOUN
mkg-954	127	30	reduction	reduction	NOUN
mkg-954	127	31	of	of	ADP
mkg-954	127	32	teeth.15	teeth.15	NOUN
mkg-954	127	33	tooth	tooth	NOUN
mkg-954	127	34	agenesis	agenesis	NOUN
mkg-954	127	35	is	be	AUX
mkg-954	127	36	a	a	DET
mkg-954	127	37	consequence	consequence	NOUN
mkg-954	127	38	of	of	ADP
mkg-954	127	39	a	a	DET
mkg-954	127	40	qualitatively	qualitatively	ADV
mkg-954	127	41	and	and	CCONJ
mkg-954	127	42	quantitatively	quantitatively	ADV
mkg-954	127	43	impaired	impaired	ADJ
mkg-954	127	44	function	function	NOUN
mkg-954	127	45	of	of	ADP
mkg-954	127	46	genetic	genetic	ADJ
mkg-954	127	47	networks	network	NOUN
mkg-954	127	48	,	,	PUNCT
mkg-954	127	49	which	which	PRON
mkg-954	127	50	regulate	regulate	VERB
mkg-954	127	51	tooth	tooth	NOUN
mkg-954	127	52	development	development	NOUN
mkg-954	127	53	.	.	PUNCT
mkg-954	128	1	impaired	impair	VERB
mkg-954	128	2	function	function	NOUN
mkg-954	128	3	of	of	ADP
mkg-954	128	4	genetic	genetic	ADJ
mkg-954	128	5	networks	network	NOUN
mkg-954	128	6	are	be	AUX
mkg-954	128	7	reflected	reflect	VERB
mkg-954	128	8	as	as	ADP
mkg-954	128	9	reduced	reduce	VERB
mkg-954	128	10	signalling	signal	VERB
mkg-954	128	11	or	or	CCONJ
mkg-954	128	12	impaired	impaired	ADJ
mkg-954	128	13	signal	signal	NOUN
mkg-954	128	14	regulation	regulation	NOUN
mkg-954	128	15	,	,	PUNCT
mkg-954	128	16	cell	cell	NOUN
mkg-954	128	17	proliferation	proliferation	NOUN
mkg-954	128	18	,	,	PUNCT
mkg-954	128	19	migration	migration	NOUN
mkg-954	128	20	and	and	CCONJ
mkg-954	128	21	differentiation	differentiation	NOUN
mkg-954	128	22	.	.	PUNCT
mkg-954	129	1	the	the	DET
mkg-954	129	2	most	most	ADV
mkg-954	129	3	critical	critical	ADJ
mkg-954	129	4	are	be	AUX
mkg-954	129	5	the	the	DET
mkg-954	129	6	stages	stage	NOUN
mkg-954	129	7	of	of	ADP
mkg-954	129	8	formation	formation	NOUN
mkg-954	129	9	of	of	ADP
mkg-954	129	10	signalling	signal	VERB
mkg-954	129	11	centres	centre	NOUN
mkg-954	129	12	that	that	PRON
mkg-954	129	13	have	have	VERB
mkg-954	129	14	an	an	DET
mkg-954	129	15	organizing	organize	VERB
mkg-954	129	16	role	role	NOUN
mkg-954	129	17	for	for	ADP
mkg-954	129	18	the	the	DET
mkg-954	129	19	future	future	ADJ
mkg-954	129	20	development	development	NOUN
mkg-954	129	21	.	.	PUNCT
mkg-954	130	1	the	the	DET
mkg-954	130	2	reduction	reduction	NOUN
mkg-954	130	3	of	of	ADP
mkg-954	130	4	the	the	DET
mkg-954	130	5	“	"	PUNCT
mkg-954	130	6	tooth	tooth	NOUN
mkg-954	130	7	forming	form	VERB
mkg-954	130	8	potential	potential	NOUN
mkg-954	130	9	”	"	PUNCT
mkg-954	130	10	may	may	AUX
mkg-954	130	11	follow	follow	VERB
mkg-954	130	12	from	from	ADP
mkg-954	130	13	a	a	DET
mkg-954	130	14	reduced	reduced	ADJ
mkg-954	130	15	functional	functional	ADJ
mkg-954	130	16	activity	activity	NOUN
mkg-954	130	17	of	of	ADP
mkg-954	130	18	a	a	DET
mkg-954	130	19	single	single	ADJ
mkg-954	130	20	gene	gene	NOUN
mkg-954	130	21	as	as	ADP
mkg-954	130	22	in	in	ADP
mkg-954	130	23	the	the	DET
mkg-954	130	24	case	case	NOUN
mkg-954	130	25	of	of	ADP
mkg-954	130	26	defects	defect	NOUN
mkg-954	130	27	in	in	ADP
mkg-954	130	28	msx1	msx1	PROPN
mkg-954	130	29	and	and	CCONJ
mkg-954	130	30	pax9.21	pax9.21	VERB
mkg-954	130	31	the	the	DET
mkg-954	130	32	number	number	NOUN
mkg-954	130	33	and	and	CCONJ
mkg-954	130	34	type	type	NOUN
mkg-954	130	35	of	of	ADP
mkg-954	130	36	teeth	tooth	NOUN
mkg-954	130	37	are	be	AUX
mkg-954	130	38	strictly	strictly	ADV
mkg-954	130	39	controlled	control	VERB
mkg-954	130	40	during	during	ADP
mkg-954	130	41	odontogenesis	odontogenesis	NOUN
mkg-954	130	42	.	.	PUNCT
mkg-954	131	1	msx1	msx1	PROPN
mkg-954	131	2	and	and	CCONJ
mkg-954	131	3	pax9	pax9	NOUN
mkg-954	131	4	form	form	VERB
mkg-954	131	5	a	a	DET
mkg-954	131	6	signalling	signal	VERB
mkg-954	131	7	cascade	cascade	NOUN
mkg-954	131	8	during	during	ADP
mkg-954	131	9	tooth	tooth	NOUN
mkg-954	131	10	development	development	NOUN
mkg-954	131	11	.	.	PUNCT
mkg-954	132	1	mutations	mutation	NOUN
mkg-954	132	2	in	in	ADP
mkg-954	132	3	msx1	msx1	PROPN
mkg-954	132	4	and	and	CCONJ
mkg-954	132	5	pax9	pax9	NOUN
mkg-954	132	6	genes	gene	NOUN
mkg-954	132	7	are	be	AUX
mkg-954	132	8	dominant	dominant	ADJ
mkg-954	132	9	for	for	ADP
mkg-954	132	10	tooth	tooth	NOUN
mkg-954	132	11	agenesis	agenesis	NOUN
mkg-954	132	12	in	in	ADP
mkg-954	132	13	humans	human	NOUN
mkg-954	132	14	.	.	PUNCT
mkg-954	133	1	the	the	DET
mkg-954	133	2	gene	gene	NOUN
mkg-954	133	3	pax9	pax9	NOUN
mkg-954	133	4	was	be	AUX
mkg-954	133	5	found	find	VERB
mkg-954	133	6	to	to	PART
mkg-954	133	7	be	be	AUX
mkg-954	133	8	localized	localize	VERB
mkg-954	133	9	in	in	ADP
mkg-954	133	10	chromosome	chromosome	NOUN
mkg-954	133	11	14	14	NUM
mkg-954	133	12	(	(	PUNCT
mkg-954	133	13	14q12	14q12	NUM
mkg-954	133	14	-	-	PUNCT
mkg-954	133	15	q13	q13	NOUN
mkg-954	133	16	)	)	PUNCT
mkg-954	133	17	.	.	PUNCT
mkg-954	134	1	the	the	DET
mkg-954	134	2	disruption	disruption	NOUN
mkg-954	134	3	of	of	ADP
mkg-954	134	4	dna	dna	NOUN
mkg-954	134	5	-	-	PUNCT
mkg-954	134	6	binding	bind	VERB
mkg-954	134	7	ability	ability	NOUN
mkg-954	134	8	of	of	ADP
mkg-954	134	9	pax9	pax9	NOUN
mkg-954	134	10	that	that	PRON
mkg-954	134	11	causes	cause	VERB
mkg-954	134	12	hypodontia	hypodontia	PROPN
mkg-954	134	13	.	.	PUNCT
mkg-954	135	1	nonsense	nonsense	NOUN
mkg-954	135	2	mutation	mutation	NOUN
mkg-954	135	3	in	in	ADP
mkg-954	135	4	exon	exon	PROPN
mkg-954	135	5	1	1	NUM
mkg-954	135	6	of	of	ADP
mkg-954	135	7	msx1	msx1	NOUN
mkg-954	135	8	in	in	ADP
mkg-954	135	9	chromosome	chromosome	NOUN
mkg-954	135	10	4	4	NUM
mkg-954	135	11	was	be	AUX
mkg-954	135	12	found	find	VERB
mkg-954	135	13	to	to	PART
mkg-954	135	14	be	be	AUX
mkg-954	135	15	heterozygous	heterozygous	ADJ
mkg-954	135	16	in	in	ADP
mkg-954	135	17	all	all	DET
mkg-954	135	18	affected	affected	ADJ
mkg-954	135	19	family	family	NOUN
mkg-954	135	20	members	member	NOUN
mkg-954	135	21	.	.	PUNCT
mkg-954	136	1	nieminen	nieminen	PROPN
mkg-954	136	2	have	have	AUX
mkg-954	136	3	identified	identify	VERB
mkg-954	136	4	there	there	PRON
mkg-954	136	5	was	be	VERB
mkg-954	136	6	gene	gene	NOUN
mkg-954	136	7	deletions	deletion	NOUN
mkg-954	136	8	in	in	ADP
mkg-954	136	9	msx1	msx1	PROPN
mkg-954	136	10	and	and	CCONJ
mkg-954	136	11	pax9	pax9	NOUN
mkg-954	136	12	,	,	PUNCT
mkg-954	136	13	missense	missense	VERB
mkg-954	136	14	mutation	mutation	NOUN
mkg-954	136	15	r196p	r196p	PROPN
mkg-954	136	16	of	of	ADP
mkg-954	136	17	msx1	msx1	PROPN
mkg-954	136	18	and	and	CCONJ
mkg-954	136	19	missense	missense	VERB
mkg-954	136	20	l21p	l21p	NOUN
mkg-954	136	21	of	of	ADP
mkg-954	136	22	pax9.21,22	pax9.21,22	NOUN
mkg-954	136	23	the	the	DET
mkg-954	136	24	key	key	ADJ
mkg-954	136	25	role	role	NOUN
mkg-954	136	26	of	of	ADP
mkg-954	136	27	msx1	msx1	PROPN
mkg-954	136	28	and	and	CCONJ
mkg-954	136	29	pax9	pax9	NOUN
mkg-954	136	30	is	be	AUX
mkg-954	136	31	to	to	PART
mkg-954	136	32	facilitate	facilitate	VERB
mkg-954	136	33	the	the	DET
mkg-954	136	34	bud	bud	NOUN
mkg-954	136	35	to	to	PART
mkg-954	136	36	cap	cap	VERB
mkg-954	136	37	stage	stage	NOUN
mkg-954	136	38	transition	transition	NOUN
mkg-954	136	39	.	.	PUNCT
mkg-954	137	1	mesenchymal	mesenchymal	ADJ
mkg-954	137	2	msx1	msx1	NOUN
mkg-954	137	3	expression	expression	NOUN
mkg-954	137	4	is	be	AUX
mkg-954	137	5	initially	initially	ADV
mkg-954	137	6	activated	activate	VERB
mkg-954	137	7	by	by	ADP
mkg-954	137	8	the	the	DET
mkg-954	137	9	epithelial	epithelial	ADJ
mkg-954	137	10	bmp4	bmp4	NOUN
mkg-954	137	11	signal	signal	NOUN
mkg-954	137	12	.	.	PUNCT
mkg-954	138	1	loss	loss	NOUN
mkg-954	138	2	of	of	ADP
mkg-954	138	3	function	function	NOUN
mkg-954	138	4	defects	defect	NOUN
mkg-954	138	5	in	in	ADP
mkg-954	138	6	msx1	msx1	PROPN
mkg-954	138	7	and	and	CCONJ
mkg-954	138	8	pax9	pax9	NOUN
mkg-954	138	9	in	in	ADP
mkg-954	138	10	humans	human	NOUN
mkg-954	138	11	cause	cause	VERB
mkg-954	138	12	partial	partial	ADJ
mkg-954	138	13	failure	failure	NOUN
mkg-954	138	14	of	of	ADP
mkg-954	138	15	tooth	tooth	NOUN
mkg-954	138	16	development	development	NOUN
mkg-954	138	17	,	,	PUNCT
mkg-954	138	18	tooth	tooth	NOUN
mkg-954	138	19	agenesis	agenesis	NOUN
mkg-954	138	20	.	.	PUNCT
mkg-954	139	1	defects	defect	NOUN
mkg-954	139	2	in	in	ADP
mkg-954	139	3	msx1	msx1	PROPN
mkg-954	139	4	associate	associate	NOUN
mkg-954	139	5	especially	especially	ADV
mkg-954	139	6	with	with	ADP
mkg-954	139	7	agenesis	agenesis	NOUN
mkg-954	139	8	of	of	ADP
mkg-954	139	9	second	second	ADJ
mkg-954	139	10	premolars	premolar	NOUN
mkg-954	139	11	and	and	CCONJ
mkg-954	139	12	third	third	ADJ
mkg-954	139	13	molars	molar	NOUN
mkg-954	139	14	,	,	PUNCT
mkg-954	139	15	whereas	whereas	SCONJ
mkg-954	139	16	the	the	DET
mkg-954	139	17	defects	defect	NOUN
mkg-954	139	18	in	in	ADP
mkg-954	139	19	pax9	pax9	NOUN
mkg-954	139	20	affect	affect	VERB
mkg-954	139	21	particularly	particularly	ADV
mkg-954	139	22	the	the	DET
mkg-954	139	23	permanent	permanent	ADJ
mkg-954	139	24	molars	molar	NOUN
mkg-954	139	25	.	.	PUNCT
mkg-954	140	1	the	the	DET
mkg-954	140	2	size	size	NOUN
mkg-954	140	3	of	of	ADP
mkg-954	140	4	the	the	DET
mkg-954	140	5	permanent	permanent	ADJ
mkg-954	140	6	teeth	tooth	NOUN
mkg-954	140	7	may	may	AUX
mkg-954	140	8	also	also	ADV
mkg-954	140	9	be	be	AUX
mkg-954	140	10	reduced	reduce	VERB
mkg-954	140	11	.	.	PUNCT
mkg-954	141	1	in	in	ADP
mkg-954	141	2	one	one	NUM
mkg-954	141	3	of	of	ADP
mkg-954	141	4	the	the	DET
mkg-954	141	5	families	family	NOUN
mkg-954	141	6	with	with	ADP
mkg-954	141	7	a	a	DET
mkg-954	141	8	defect	defect	NOUN
mkg-954	141	9	in	in	ADP
mkg-954	141	10	msx1	msx1	PROPN
mkg-954	141	11	,	,	PUNCT
mkg-954	141	12	some	some	DET
mkg-954	141	13	patients	patient	NOUN
mkg-954	141	14	also	also	ADV
mkg-954	141	15	presented	present	VERB
mkg-954	141	16	with	with	ADP
mkg-954	141	17	nail	nail	NOUN
mkg-954	141	18	dysplasia	dysplasia	NOUN
mkg-954	141	19	and	and	CCONJ
mkg-954	141	20	in	in	ADP
mkg-954	141	21	another	another	DET
mkg-954	141	22	family	family	NOUN
mkg-954	141	23	with	with	ADP
mkg-954	141	24	oral	oral	ADJ
mkg-954	141	25	clefts	cleft	NOUN
mkg-954	141	26	.	.	PUNCT
mkg-954	142	1	several	several	ADJ
mkg-954	142	2	other	other	ADJ
mkg-954	142	3	sequence	sequence	NOUN
mkg-954	142	4	changes	change	NOUN
mkg-954	142	5	in	in	ADP
mkg-954	142	6	msx1	msx1	PROPN
mkg-954	142	7	have	have	AUX
mkg-954	142	8	also	also	ADV
mkg-954	142	9	been	be	AUX
mkg-954	142	10	described	describe	VERB
mkg-954	142	11	in	in	ADP
mkg-954	142	12	connection	connection	NOUN
mkg-954	142	13	with	with	ADP
mkg-954	142	14	oral	oral	ADJ
mkg-954	142	15	clefting	clefting	NOUN
mkg-954	142	16	.	.	PUNCT
mkg-954	143	1	in	in	ADP
mkg-954	143	2	addition	addition	NOUN
mkg-954	143	3	,	,	PUNCT
mkg-954	143	4	a	a	DET
mkg-954	143	5	micro	micro	ADJ
mkg-954	143	6	satellite	satellite	NOUN
mkg-954	143	7	allele	allele	NOUN
mkg-954	143	8	in	in	ADP
mkg-954	143	9	the	the	DET
mkg-954	143	10	intron	intron	NOUN
mkg-954	143	11	of	of	ADP
mkg-954	143	12	msx1	msx1	PROPN
mkg-954	143	13	has	have	AUX
mkg-954	143	14	been	be	AUX
mkg-954	143	15	associated	associate	VERB
mkg-954	143	16	with	with	ADP
mkg-954	143	17	both	both	DET
mkg-954	143	18	tooth	tooth	NOUN
mkg-954	143	19	agenesis	agenesis	NOUN
mkg-954	143	20	and	and	CCONJ
mkg-954	143	21	oral	oral	ADJ
mkg-954	143	22	clefting	clefting	NOUN
mkg-954	143	23	,	,	PUNCT
mkg-954	143	24	and	and	CCONJ
mkg-954	143	25	two	two	NUM
mkg-954	143	26	promoter	promoter	NOUN
mkg-954	143	27	region	region	NOUN
mkg-954	143	28	snp	snp	ADJ
mkg-954	143	29	alleles	allele	NOUN
mkg-954	143	30	of	of	ADP
mkg-954	143	31	pax9	pax9	NOUN
mkg-954	143	32	with	with	ADP
mkg-954	143	33	tooth	tooth	NOUN
mkg-954	143	34	agenesis.17,23	agenesis.17,23	NOUN
mkg-954	143	35	in	in	ADP
mkg-954	143	36	the	the	DET
mkg-954	143	37	case	case	NOUN
mkg-954	143	38	of	of	ADP
mkg-954	143	39	msx1	msx1	PROPN
mkg-954	143	40	and	and	CCONJ
mkg-954	143	41	pax9	pax9	NOUN
mkg-954	143	42	,	,	PUNCT
mkg-954	143	43	tooth	tooth	NOUN
mkg-954	143	44	agenesis	agenesis	NOUN
mkg-954	143	45	has	have	AUX
mkg-954	143	46	been	be	AUX
mkg-954	143	47	related	relate	VERB
mkg-954	143	48	to	to	ADP
mkg-954	143	49	critical	critical	ADJ
mkg-954	143	50	function	function	NOUN
mkg-954	143	51	of	of	ADP
mkg-954	143	52	the	the	DET
mkg-954	143	53	mouse	mouse	NOUN
mkg-954	143	54	homologues	homologue	NOUN
mkg-954	143	55	of	of	ADP
mkg-954	143	56	these	these	DET
mkg-954	143	57	genes	gene	NOUN
mkg-954	143	58	in	in	ADP
mkg-954	143	59	the	the	DET
mkg-954	143	60	formation	formation	NOUN
mkg-954	143	61	of	of	ADP
mkg-954	143	62	the	the	DET
mkg-954	143	63	enamel	enamel	NOUN
mkg-954	143	64	knot	knot	NOUN
mkg-954	143	65	and	and	CCONJ
mkg-954	143	66	the	the	DET
mkg-954	143	67	subsequent	subsequent	ADJ
mkg-954	143	68	transition	transition	NOUN
mkg-954	143	69	from	from	ADP
mkg-954	143	70	bud	bud	NOUN
mkg-954	143	71	to	to	PART
mkg-954	143	72	cap	cap	VERB
mkg-954	143	73	stages	stage	NOUN
mkg-954	143	74	.	.	PUNCT
mkg-954	144	1	the	the	DET
mkg-954	144	2	msx1	msx1	PROPN
mkg-954	144	3	haploinsufficiency	haploinsufficiency	PROPN
mkg-954	144	4	,	,	PUNCT
mkg-954	144	5	however	however	ADV
mkg-954	144	6	,	,	PUNCT
mkg-954	144	7	appear	appear	VERB
mkg-954	144	8	to	to	PART
mkg-954	144	9	affect	affect	VERB
mkg-954	144	10	only	only	ADV
mkg-954	144	11	secondary	secondary	ADJ
mkg-954	144	12	teeth	tooth	NOUN
mkg-954	144	13	and	and	CCONJ
mkg-954	144	14	permanent	permanent	ADJ
mkg-954	144	15	molars	molar	NOUN
mkg-954	144	16	,	,	PUNCT
mkg-954	144	17	and	and	CCONJ
mkg-954	144	18	it	it	PRON
mkg-954	144	19	is	be	AUX
mkg-954	144	20	not	not	PART
mkg-954	144	21	obvious	obvious	ADJ
mkg-954	144	22	how	how	SCONJ
mkg-954	144	23	a	a	DET
mkg-954	144	24	weakened	weakened	ADJ
mkg-954	144	25	enamel	enamel	NOUN
mkg-954	144	26	knot	knot	NOUN
mkg-954	144	27	function	function	NOUN
mkg-954	144	28	,	,	PUNCT
mkg-954	144	29	which	which	PRON
mkg-954	144	30	presumably	presumably	ADV
mkg-954	144	31	follows	follow	VERB
mkg-954	144	32	from	from	ADP
mkg-954	144	33	a	a	DET
mkg-954	144	34	reduced	reduce	VERB
mkg-954	144	35	amount	amount	NOUN
mkg-954	144	36	of	of	ADP
mkg-954	144	37	functional	functional	ADJ
mkg-954	144	38	msx1	msx1	ADJ
mkg-954	144	39	protein	protein	NOUN
mkg-954	144	40	,	,	PUNCT
mkg-954	144	41	is	be	AUX
mkg-954	144	42	linked	link	VERB
mkg-954	144	43	to	to	ADP
mkg-954	144	44	impaired	impaired	ADJ
mkg-954	144	45	secondary	secondary	ADJ
mkg-954	144	46	tooth	tooth	NOUN
mkg-954	144	47	development	development	NOUN
mkg-954	144	48	.	.	PUNCT
mkg-954	145	1	it	it	PRON
mkg-954	145	2	is	be	AUX
mkg-954	145	3	possible	possible	ADJ
mkg-954	145	4	that	that	SCONJ
mkg-954	145	5	the	the	DET
mkg-954	145	6	late	late	ADJ
mkg-954	145	7	developing	develop	VERB
mkg-954	145	8	teeth	tooth	NOUN
mkg-954	145	9	are	be	AUX
mkg-954	145	10	more	more	ADV
mkg-954	145	11	sensitive	sensitive	ADJ
mkg-954	145	12	to	to	ADP
mkg-954	145	13	impaired	impaired	ADJ
mkg-954	145	14	enamel	enamel	NOUN
mkg-954	145	15	knot	knot	NOUN
mkg-954	145	16	function	function	NOUN
mkg-954	145	17	.	.	PUNCT
mkg-954	146	1	the	the	DET
mkg-954	146	2	development	development	NOUN
mkg-954	146	3	of	of	ADP
mkg-954	146	4	these	these	DET
mkg-954	146	5	teeth	tooth	NOUN
mkg-954	146	6	normally	normally	ADV
mkg-954	146	7	is	be	AUX
mkg-954	146	8	a	a	DET
mkg-954	146	9	long	long	ADV
mkg-954	146	10	lasting	last	VERB
mkg-954	146	11	process	process	NOUN
mkg-954	146	12	and	and	CCONJ
mkg-954	146	13	happens	happens	AUX
mkg-954	146	14	surrounded	surround	VERB
mkg-954	146	15	by	by	ADP
mkg-954	146	16	the	the	DET
mkg-954	146	17	alveolar	alveolar	ADJ
mkg-954	146	18	bone	bone	NOUN
mkg-954	146	19	.	.	PUNCT
mkg-954	147	1	it	it	PRON
mkg-954	147	2	can	can	AUX
mkg-954	147	3	also	also	ADV
mkg-954	147	4	be	be	AUX
mkg-954	147	5	speculated	speculate	VERB
mkg-954	147	6	that	that	SCONJ
mkg-954	147	7	enamel	enamel	NOUN
mkg-954	147	8	knots	knot	NOUN
mkg-954	147	9	may	may	AUX
mkg-954	147	10	regulate	regulate	VERB
mkg-954	147	11	the	the	DET
mkg-954	147	12	program	program	NOUN
mkg-954	147	13	leading	lead	VERB
mkg-954	147	14	to	to	ADP
mkg-954	147	15	the	the	DET
mkg-954	147	16	secondary	secondary	ADJ
mkg-954	147	17	tooth	tooth	NOUN
mkg-954	147	18	formation.23	formation.23	ADV
mkg-954	147	19	it	it	PRON
mkg-954	147	20	is	be	AUX
mkg-954	147	21	concluded	conclude	VERB
mkg-954	147	22	that	that	SCONJ
mkg-954	147	23	based	base	VERB
mkg-954	147	24	on	on	ADP
mkg-954	147	25	the	the	DET
mkg-954	147	26	molecular	molecular	NOUN
mkg-954	147	27	andbased	andbase	VERB
mkg-954	147	28	on	on	ADP
mkg-954	147	29	the	the	DET
mkg-954	147	30	molecular	molecular	ADJ
mkg-954	147	31	and	and	CCONJ
mkg-954	147	32	genetic	genetic	ADJ
mkg-954	147	33	studies	study	NOUN
mkg-954	147	34	of	of	ADP
mkg-954	147	35	tooth	tooth	NOUN
mkg-954	147	36	development	development	NOUN
mkg-954	147	37	,	,	PUNCT
mkg-954	147	38	tooth	tooth	NOUN
mkg-954	147	39	agenesis	agenesis	NOUN
mkg-954	147	40	is	be	AUX
mkg-954	147	41	a	a	DET
mkg-954	147	42	consequence	consequence	NOUN
mkg-954	147	43	of	of	ADP
mkg-954	147	44	a	a	DET
mkg-954	147	45	qualitatively	qualitatively	ADV
mkg-954	147	46	or	or	CCONJ
mkg-954	147	47	quantitatively	quantitatively	ADV
mkg-954	147	48	impaired	impaired	ADJ
mkg-954	147	49	function	function	NOUN
mkg-954	147	50	of	of	ADP
mkg-954	147	51	genetic	genetic	ADJ
mkg-954	147	52	networks	network	NOUN
mkg-954	147	53	,	,	PUNCT
mkg-954	147	54	which	which	PRON
mkg-954	147	55	regulate	regulate	VERB
mkg-954	147	56	tooth	tooth	NOUN
mkg-954	147	57	development	development	NOUN
mkg-954	147	58	.	.	PUNCT
mkg-954	148	1	reduced	reduce	VERB
mkg-954	148	2	amount	amount	NOUN
mkg-954	148	3	of	of	ADP
mkg-954	148	4	functional	functional	ADJ
mkg-954	148	5	msx1	msx1	NOUN
mkg-954	148	6	or	or	CCONJ
mkg-954	148	7	pax9	pax9	NOUN
mkg-954	148	8	protein	protein	NOUN
mkg-954	148	9	in	in	ADP
mkg-954	148	10	the	the	DET
mkg-954	148	11	tooth	tooth	NOUN
mkg-954	148	12	forming	form	VERB
mkg-954	148	13	cells	cell	NOUN
mkg-954	148	14	is	be	AUX
mkg-954	148	15	able	able	ADJ
mkg-954	148	16	to	to	PART
mkg-954	148	17	cause	cause	VERB
mkg-954	148	18	severe	severe	ADJ
mkg-954	148	19	and	and	CCONJ
mkg-954	148	20	selective	selective	ADJ
mkg-954	148	21	tooth	tooth	NOUN
mkg-954	148	22	agenesis	agenesis	NOUN
mkg-954	148	23	.	.	PUNCT
mkg-954	149	1	another	another	DET
mkg-954	149	2	conclusion	conclusion	NOUN
mkg-954	149	3	,	,	PUNCT
mkg-954	149	4	based	base	VERB
mkg-954	149	5	on	on	ADP
mkg-954	149	6	the	the	DET
mkg-954	149	7	analysis	analysis	NOUN
mkg-954	149	8	of	of	ADP
mkg-954	149	9	the	the	DET
mkg-954	149	10	phenotypes	phenotype	NOUN
mkg-954	149	11	associated	associate	VERB
mkg-954	149	12	with	with	ADP
mkg-954	149	13	the	the	DET
mkg-954	149	14	known	know	VERB
mkg-954	149	15	defects	defect	NOUN
mkg-954	149	16	in	in	ADP
mkg-954	149	17	these	these	DET
mkg-954	149	18	genes	gene	NOUN
mkg-954	149	19	,	,	PUNCT
mkg-954	149	20	is	be	AUX
mkg-954	149	21	that	that	SCONJ
mkg-954	149	22	the	the	DET
mkg-954	149	23	phenotypes	phenotype	NOUN
mkg-954	149	24	associated	associate	VERB
mkg-954	149	25	with	with	ADP
mkg-954	149	26	the	the	DET
mkg-954	149	27	defects	defect	NOUN
mkg-954	149	28	in	in	ADP
mkg-954	149	29	msx1	msx1	PROPN
mkg-954	149	30	and	and	CCONJ
mkg-954	149	31	those	those	PRON
mkg-954	149	32	associated	associate	VERB
mkg-954	149	33	with	with	ADP
mkg-954	149	34	the	the	DET
mkg-954	149	35	defects	defect	NOUN
mkg-954	149	36	in	in	ADP
mkg-954	149	37	pax9	pax9	NOUN
mkg-954	149	38	are	be	AUX
mkg-954	149	39	different	different	ADJ
mkg-954	149	40	.	.	PUNCT
mkg-954	150	1	despite	despite	SCONJ
mkg-954	150	2	the	the	DET
mkg-954	150	3	similarities	similarity	NOUN
mkg-954	150	4	,	,	PUNCT
mkg-954	150	5	there	there	PRON
mkg-954	150	6	are	be	VERB
mkg-954	150	7	clearcut	clearcut	VERB
mkg-954	150	8	differences	difference	NOUN
mkg-954	150	9	in	in	ADP
mkg-954	150	10	the	the	DET
mkg-954	150	11	frequency	frequency	NOUN
mkg-954	150	12	of	of	ADP
mkg-954	150	13	agenesis	agenesis	NOUN
mkg-954	150	14	of	of	ADP
mkg-954	150	15	specific	specific	ADJ
mkg-954	150	16	teeth	tooth	NOUN
mkg-954	150	17	.	.	PUNCT
mkg-954	151	1	references	reference	NOUN
mkg-954	151	2	1	1	NUM
mkg-954	151	3	.	.	PUNCT
mkg-954	152	1	nieminen	nieminen	PROPN
mkg-954	152	2	p.	p.	NOUN
mkg-954	152	3	molecular	molecular	ADJ
mkg-954	152	4	genetics	genetic	NOUN
mkg-954	152	5	of	of	ADP
mkg-954	152	6	tooth	tooth	NOUN
mkg-954	152	7	agenesis	agenesis	NOUN
mkg-954	152	8	.	.	PUNCT
mkg-954	153	1	dissertation	dissertation	NOUN
mkg-954	153	2	.	.	PUNCT
mkg-954	154	1	finlandia	finlandia	PROPN
mkg-954	154	2	:	:	PUNCT
mkg-954	154	3	department	department	NOUN
mkg-954	154	4	of	of	ADP
mkg-954	154	5	orthodontics	orthodontics	PROPN
mkg-954	154	6	institute	institute	PROPN
mkg-954	154	7	of	of	ADP
mkg-954	154	8	dentistry	dentistry	PROPN
mkg-954	154	9	and	and	CCONJ
mkg-954	154	10	institute	institute	PROPN
mkg-954	154	11	of	of	ADP
mkg-954	154	12	biotechnology	biotechnology	NOUN
mkg-954	154	13	and	and	CCONJ
mkg-954	154	14	department	department	NOUN
mkg-954	154	15	of	of	ADP
mkg-954	154	16	biological	biological	ADJ
mkg-954	154	17	and	and	CCONJ
mkg-954	154	18	environmental	environmental	ADJ
mkg-954	154	19	sciences	sciences	PROPN
mkg-954	154	20	faculty	faculty	NOUN
mkg-954	154	21	of	of	ADP
mkg-954	154	22	biosciences	biosciences	PROPN
mkg-954	154	23	university	university	PROPN
mkg-954	154	24	of	of	ADP
mkg-954	154	25	helsinki	helsinki	PROPN
mkg-954	154	26	;	;	PUNCT
mkg-954	154	27	2007	2007	NUM
mkg-954	154	28	.	.	PUNCT
mkg-954	155	1	p.	p.	NOUN
mkg-954	155	2	48–60	48–60	PROPN
mkg-954	155	3	.	.	PUNCT
mkg-954	156	1	2	2	X
mkg-954	156	2	.	.	X
mkg-954	156	3	londhe	londhe	PROPN
mkg-954	156	4	sm	sm	PROPN
mkg-954	156	5	,	,	PUNCT
mkg-954	156	6	viswambaran	viswambaran	NOUN
mkg-954	156	7	m	m	PROPN
mkg-954	156	8	,	,	PUNCT
mkg-954	156	9	kumar	kumar	PROPN
mkg-954	156	10	p.	p.	PROPN
mkg-954	156	11	multidisciplinary	multidisciplinary	ADJ
mkg-954	156	12	management	management	NOUN
mkg-954	156	13	of	of	ADP
mkg-954	156	14	oligodontia	oligodontia	PROPN
mkg-954	156	15	.	.	PUNCT
mkg-954	157	1	mjafi	mjafi	PROPN
mkg-954	157	2	2008	2008	NUM
mkg-954	157	3	;	;	PUNCT
mkg-954	157	4	64	64	NUM
mkg-954	157	5	:	:	PUNCT
mkg-954	157	6	67–69	67–69	NUM
mkg-954	157	7	.	.	NOUN
mkg-954	157	8	3	3	X
mkg-954	157	9	.	.	X
mkg-954	157	10	arte	arte	PROPN
mkg-954	157	11	s.	s.	PROPN
mkg-954	157	12	phenotypic	phenotypic	PROPN
mkg-954	157	13	and	and	CCONJ
mkg-954	157	14	genotypic	genotypic	NOUN
mkg-954	157	15	features	feature	NOUN
mkg-954	157	16	of	of	ADP
mkg-954	157	17	familial	familial	ADJ
mkg-954	157	18	hypodontia	hypodontia	NOUN
mkg-954	157	19	.	.	PUNCT
mkg-954	158	1	thesis	thesis	NOUN
mkg-954	158	2	.	.	PUNCT
mkg-954	159	1	helsinki	helsinki	PROPN
mkg-954	159	2	:	:	PUNCT
mkg-954	159	3	department	department	NOUN
mkg-954	159	4	of	of	ADP
mkg-954	159	5	oral	oral	ADJ
mkg-954	159	6	and	and	CCONJ
mkg-954	159	7	maxillofacial	maxillofacial	ADJ
mkg-954	159	8	disease	disease	NOUN
mkg-954	159	9	university	university	PROPN
mkg-954	159	10	of	of	ADP
mkg-954	159	11	helsinki	helsinki	PROPN
mkg-954	159	12	;	;	PUNCT
mkg-954	159	13	2001	2001	NUM
mkg-954	159	14	.	.	PUNCT
mkg-954	160	1	p.	p.	NOUN
mkg-954	160	2	203–87	203–87	NOUN
mkg-954	160	3	.	.	PUNCT
mkg-954	161	1	4	4	X
mkg-954	161	2	.	.	X
mkg-954	161	3	näsman	näsman	PROPN
mkg-954	161	4	m	m	PROPN
mkg-954	161	5	,	,	PUNCT
mkg-954	161	6	forsberg	forsberg	PROPN
mkg-954	161	7	cm	cm	PROPN
mkg-954	161	8	,	,	PUNCT
mkg-954	161	9	dahllöf	dahllöf	PROPN
mkg-954	161	10	g.	g.	PROPN
mkg-954	161	11	long	long	ADJ
mkg-954	161	12	-	-	PUNCT
mkg-954	161	13	term	term	NOUN
mkg-954	161	14	dental	dental	ADJ
mkg-954	161	15	development	development	NOUN
mkg-954	161	16	in	in	ADP
mkg-954	161	17	children	child	NOUN
mkg-954	161	18	after	after	ADP
mkg-954	161	19	treatment	treatment	NOUN
mkg-954	161	20	for	for	ADP
mkg-954	161	21	malignant	malignant	ADJ
mkg-954	161	22	disease	disease	NOUN
mkg-954	161	23	.	.	PUNCT
mkg-954	162	1	eur	eur	PROPN
mkg-954	162	2	j	j	PROPN
mkg-954	162	3	orthod	orthod	NOUN
mkg-954	162	4	1997	1997	NUM
mkg-954	162	5	;	;	PUNCT
mkg-954	162	6	19	19	NUM
mkg-954	162	7	:	:	SYM
mkg-954	162	8	151–9	151–9	NUM
mkg-954	162	9	.	.	NOUN
mkg-954	162	10	5	5	NUM
mkg-954	162	11	.	.	X
mkg-954	163	1	vastardis	vastardi	NOUN
mkg-954	163	2	h.	h.	PROPN
mkg-954	163	3	the	the	DET
mkg-954	163	4	genetics	genetic	NOUN
mkg-954	163	5	of	of	ADP
mkg-954	163	6	human	human	ADJ
mkg-954	163	7	tooth	tooth	NOUN
mkg-954	163	8	agenesis	agenesis	NOUN
mkg-954	163	9	:	:	PUNCT
mkg-954	163	10	new	new	ADJ
mkg-954	163	11	discoveriesastardis	discoveriesastardis	PROPN
mkg-954	163	12	h.	h.	PROPN
mkg-954	164	1	the	the	DET
mkg-954	164	2	genetics	genetic	NOUN
mkg-954	164	3	of	of	ADP
mkg-954	164	4	human	human	ADJ
mkg-954	164	5	tooth	tooth	NOUN
mkg-954	164	6	agenesis	agenesis	NOUN
mkg-954	164	7	:	:	PUNCT
mkg-954	164	8	new	new	ADJ
mkg-954	164	9	discoveries	discovery	NOUN
mkg-954	164	10	for	for	ADP
mkg-954	164	11	understanding	understand	VERB
mkg-954	164	12	dental	dental	ADJ
mkg-954	164	13	anomalies	anomaly	NOUN
mkg-954	164	14	.	.	PUNCT
mkg-954	165	1	am	be	AUX
mkg-954	165	2	j	j	PROPN
mkg-954	165	3	orthod	orthod	NOUN
mkg-954	165	4	dentofac	dentofac	NOUN
mkg-954	165	5	orthop	orthop	NOUN
mkg-954	165	6	2000	2000	NUM
mkg-954	165	7	;	;	PUNCT
mkg-954	165	8	117	117	NUM
mkg-954	165	9	:	:	PUNCT
mkg-954	165	10	650–6	650–6	NUM
mkg-954	165	11	.	.	PROPN
mkg-954	165	12	6	6	NUM
mkg-954	165	13	.	.	X
mkg-954	165	14	peck	peck	PROPN
mkg-954	165	15	s	s	PART
mkg-954	165	16	,	,	PUNCT
mkg-954	165	17	peck	peck	PROPN
mkg-954	165	18	l	l	PROPN
mkg-954	165	19	,	,	PUNCT
mkg-954	165	20	kataja	kataja	PROPN
mkg-954	165	21	m.	m.	PROPN
mkg-954	165	22	mandibular	mandibular	PROPN
mkg-954	165	23	lateral	lateral	ADJ
mkg-954	165	24	incisor	incisor	NOUN
mkg-954	165	25	-	-	PUNCT
mkg-954	165	26	canine	canine	NOUN
mkg-954	165	27	transposition	transposition	NOUN
mkg-954	165	28	,	,	PUNCT
mkg-954	165	29	concomitant	concomitant	ADJ
mkg-954	165	30	dental	dental	ADJ
mkg-954	165	31	anomalies	anomaly	NOUN
mkg-954	165	32	,	,	PUNCT
mkg-954	165	33	and	and	CCONJ
mkg-954	165	34	genetic	genetic	ADJ
mkg-954	165	35	control	control	NOUN
mkg-954	165	36	.	.	PUNCT
mkg-954	166	1	am	be	AUX
mkg-954	166	2	j	j	PROPN
mkg-954	166	3	orthod	orthod	NOUN
mkg-954	166	4	dentofac	dentofac	NOUN
mkg-954	166	5	orthop	orthop	NOUN
mkg-954	166	6	2000	2000	NUM
mkg-954	166	7	;	;	PUNCT
mkg-954	166	8	117	117	NUM
mkg-954	166	9	:	:	PUNCT
mkg-954	166	10	650–6	650–6	NUM
mkg-954	166	11	.	.	PROPN
mkg-954	166	12	7	7	X
mkg-954	166	13	.	.	X
mkg-954	166	14	thesleff	thesleff	PROPN
mkg-954	166	15	i	i	PROPN
mkg-954	166	16	,	,	PUNCT
mkg-954	166	17	keränen	keränen	PROPN
mkg-954	166	18	s	s	PROPN
mkg-954	166	19	,	,	PUNCT
mkg-954	166	20	jernvall	jernvall	PROPN
mkg-954	166	21	j.	j.	PROPN
mkg-954	166	22	enamel	enamel	PROPN
mkg-954	166	23	knots	knot	NOUN
mkg-954	166	24	as	as	ADP
mkg-954	166	25	signalling	signal	VERB
mkg-954	166	26	centres	centre	NOUN
mkg-954	166	27	thesleff	thesleff	NOUN
mkg-954	166	28	i	i	PROPN
mkg-954	166	29	,	,	PUNCT
mkg-954	166	30	keränen	keränen	PROPN
mkg-954	166	31	s	s	PROPN
mkg-954	166	32	,	,	PUNCT
mkg-954	166	33	jernvall	jernvall	PROPN
mkg-954	166	34	j.	j.	PROPN
mkg-954	166	35	enamel	enamel	PROPN
mkg-954	166	36	knots	knot	NOUN
mkg-954	166	37	as	as	ADP
mkg-954	166	38	signalling	signal	VERB
mkg-954	166	39	centres	centre	NOUN
mkg-954	166	40	linking	link	VERB
mkg-954	166	41	tooth	tooth	NOUN
mkg-954	166	42	morphogenesis	morphogenesis	NOUN
mkg-954	166	43	and	and	CCONJ
mkg-954	166	44	odontoblast	odontoblast	ADJ
mkg-954	166	45	differentiation	differentiation	NOUN
mkg-954	166	46	.	.	PUNCT
mkg-954	167	1	adv	adv	PROPN
mkg-954	167	2	dent	dent	NOUN
mkg-954	167	3	res	re	NOUN
mkg-954	167	4	2001	2001	NUM
mkg-954	167	5	;	;	PUNCT
mkg-954	167	6	15	15	NUM
mkg-954	167	7	:	:	PUNCT
mkg-954	167	8	14–8	14–8	NUM
mkg-954	167	9	.	.	PUNCT
mkg-954	168	1	8	8	NUM
mkg-954	168	2	.	.	X
mkg-954	168	3	moore	moore	PROPN
mkg-954	168	4	kl	kl	PROPN
mkg-954	168	5	,	,	PUNCT
mkg-954	168	6	persaud	persaud	PROPN
mkg-954	168	7	tvn	tvn	PROPN
mkg-954	168	8	.	.	PUNCT
mkg-954	168	9	embriología	embriología	PROPN
mkg-954	168	10	clínica	clínica	PROPN
mkg-954	168	11	.	.	PUNCT
mkg-954	169	1	7th	7th	ADJ
mkg-954	169	2	ed	ed	NOUN
mkg-954	169	3	.	.	PUNCT
mkg-954	170	1	madrid	madrid	PROPN
mkg-954	170	2	:	:	PUNCT
mkg-954	170	3	elsevier;madrid	elsevier;madrid	PROPN
mkg-954	170	4	:	:	PUNCT
mkg-954	170	5	elsevier	elsevier	NOUN
mkg-954	170	6	;	;	PUNCT
mkg-954	170	7	2004	2004	NUM
mkg-954	170	8	.	.	PUNCT
mkg-954	171	1	p.	p.	NOUN
mkg-954	171	2	30–7	30–7	NUM
mkg-954	171	3	.	.	PUNCT
mkg-954	172	1	9	9	NUM
mkg-954	172	2	.	.	X
mkg-954	172	3	thesleff	thesleff	PROPN
mkg-954	172	4	i.	i.	PROPN
mkg-954	172	5	genetic	genetic	ADJ
mkg-954	172	6	basis	basis	NOUN
mkg-954	172	7	of	of	ADP
mkg-954	172	8	tooth	tooth	NOUN
mkg-954	172	9	development	development	NOUN
mkg-954	172	10	and	and	CCONJ
mkg-954	172	11	dental	dental	ADJ
mkg-954	172	12	defects.thesleff	defects.thesleff	NOUN
mkg-954	172	13	i.	i.	NOUN
mkg-954	172	14	genetic	genetic	ADJ
mkg-954	172	15	basis	basis	NOUN
mkg-954	172	16	of	of	ADP
mkg-954	172	17	tooth	tooth	NOUN
mkg-954	172	18	development	development	NOUN
mkg-954	172	19	and	and	CCONJ
mkg-954	172	20	dental	dental	ADJ
mkg-954	172	21	defects	defect	NOUN
mkg-954	172	22	.	.	PUNCT
mkg-954	173	1	acta	acta	PROPN
mkg-954	173	2	odontol	odontol	PROPN
mkg-954	173	3	scand	scand	PROPN
mkg-954	173	4	2000	2000	NUM
mkg-954	173	5	;	;	PUNCT
mkg-954	173	6	58	58	NUM
mkg-954	173	7	:	:	PUNCT
mkg-954	173	8	191–4	191–4	NUM
mkg-954	173	9	.	.	PROPN
mkg-954	174	1	146	146	NUM
mkg-954	174	2	dent	dent	NOUN
mkg-954	174	3	.	.	PUNCT
mkg-954	175	1	j.	j.	PROPN
mkg-954	175	2	(	(	PUNCT
mkg-954	175	3	maj	maj	PROPN
mkg-954	175	4	.	.	PROPN
mkg-954	175	5	ked	ked	PROPN
mkg-954	175	6	.	.	PUNCT
mkg-954	176	1	gigi	gigi	PROPN
mkg-954	176	2	)	)	PUNCT
mkg-954	176	3	,	,	PUNCT
mkg-954	177	1	vol	vol	NOUN
mkg-954	177	2	.	.	PUNCT
mkg-954	178	1	42	42	NUM
mkg-954	178	2	.	.	PUNCT
mkg-954	179	1	no	no	INTJ
mkg-954	179	2	.	.	NOUN
mkg-954	180	1	3	3	NUM
mkg-954	180	2	july	july	PROPN
mkg-954	180	3	–	–	PUNCT
mkg-954	180	4	september	september	PROPN
mkg-954	180	5	2009	2009	NUM
mkg-954	180	6	:	:	PUNCT
mkg-954	180	7	141	141	NUM
mkg-954	180	8	-	-	SYM
mkg-954	180	9	146	146	NUM
mkg-954	180	10	10	10	NUM
mkg-954	180	11	.	.	PUNCT
mkg-954	181	1	yüksel	yüksel	PROPN
mkg-954	181	2	s	s	PROPN
mkg-954	181	3	,	,	PUNCT
mkg-954	181	4	uçem	uçem	ADJ
mkg-954	181	5	t.	t.	PROPN
mkg-954	181	6	the	the	DET
mkg-954	181	7	effect	effect	NOUN
mkg-954	181	8	of	of	ADP
mkg-954	181	9	tooth	tooth	NOUN
mkg-954	181	10	agenesis	agenesis	NOUN
mkg-954	181	11	on	on	ADP
mkg-954	181	12	dentofacial	dentofacial	ADJ
mkg-954	181	13	structures	structure	NOUN
mkg-954	181	14	.	.	PUNCT
mkg-954	182	1	eur	eur	PROPN
mkg-954	182	2	j	j	PROPN
mkg-954	182	3	orthod	orthod	NOUN
mkg-954	182	4	1997	1997	NUM
mkg-954	182	5	;	;	PUNCT
mkg-954	182	6	19	19	NUM
mkg-954	182	7	:	:	PUNCT
mkg-954	182	8	71–8	71–8	NOUN
mkg-954	182	9	.	.	PUNCT
mkg-954	182	10	11	11	NUM
mkg-954	182	11	.	.	PUNCT
mkg-954	183	1	peters	peters	PROPN
mkg-954	183	2	h	h	PROPN
mkg-954	183	3	,	,	PUNCT
mkg-954	183	4	balling	ball	VERB
mkg-954	183	5	r.	r.	PROPN
mkg-954	183	6	teeth	teeth	PROPN
mkg-954	183	7	-	-	PUNCT
mkg-954	183	8	where	where	SCONJ
mkg-954	183	9	and	and	CCONJ
mkg-954	183	10	how	how	SCONJ
mkg-954	183	11	to	to	PART
mkg-954	183	12	make	make	VERB
mkg-954	183	13	them	they	PRON
mkg-954	183	14	.	.	PUNCT
mkg-954	184	1	trends	trend	NOUN
mkg-954	184	2	genet	genet	PROPN
mkg-954	184	3	1999	1999	NUM
mkg-954	184	4	;	;	PUNCT
mkg-954	184	5	15	15	NUM
mkg-954	184	6	:	:	SYM
mkg-954	184	7	59–65	59–65	NUM
mkg-954	184	8	.	.	PUNCT
mkg-954	184	9	12	12	NUM
mkg-954	184	10	.	.	PUNCT
mkg-954	185	1	jiménez	jiménez	PROPN
mkg-954	185	2	e	e	PROPN
mkg-954	185	3	,	,	PUNCT
mkg-954	185	4	castellanos	castellanos	PROPN
mkg-954	185	5	a	a	PRON
mkg-954	185	6	,	,	PUNCT
mkg-954	185	7	carmona1	carmona1	PROPN
mkg-954	185	8	cj	cj	PROPN
mkg-954	185	9	,	,	PUNCT
mkg-954	185	10	herrera	herrera	PROPN
mkg-954	185	11	c.	c.	NOUN
mkg-954	185	12	variations	variation	NOUN
mkg-954	185	13	in	in	ADP
mkg-954	185	14	the	the	DET
mkg-954	185	15	number	number	NOUN
mkg-954	185	16	of	of	ADP
mkg-954	185	17	human	human	ADJ
mkg-954	185	18	permanent	permanent	ADJ
mkg-954	185	19	teeth	tooth	NOUN
mkg-954	185	20	:	:	PUNCT
mkg-954	185	21	hypodontia	hypodontia	PROPN
mkg-954	185	22	.	.	PUNCT
mkg-954	186	1	eur	eur	PROPN
mkg-954	186	2	j	j	PROPN
mkg-954	186	3	anat	anat	PROPN
mkg-954	186	4	2005	2005	NUM
mkg-954	186	5	;	;	PUNCT
mkg-954	186	6	9(1	9(1	NUM
mkg-954	186	7	):	):	PUNCT
mkg-954	186	8	23–7	23–7	NUM
mkg-954	186	9	.	.	PUNCT
mkg-954	187	1	13	13	NUM
mkg-954	187	2	.	.	PUNCT
mkg-954	187	3	lidral	lidral	PROPN
mkg-954	187	4	ac	ac	PROPN
mkg-954	187	5	,	,	PUNCT
mkg-954	187	6	reising	reising	PROPN
mkg-954	187	7	bc	bc	PROPN
mkg-954	187	8	.	.	PUNCT
mkg-954	188	1	the	the	DET
mkg-954	188	2	role	role	NOUN
mkg-954	188	3	of	of	ADP
mkg-954	188	4	msx1	msx1	PROPN
mkg-954	188	5	in	in	ADP
mkg-954	188	6	human	human	ADJ
mkg-954	188	7	tooth	tooth	NOUN
mkg-954	188	8	agenesis	agenesis	NOUN
mkg-954	188	9	..	..	PUNCT
mkg-954	188	10	the	the	DET
mkg-954	188	11	role	role	NOUN
mkg-954	188	12	of	of	ADP
mkg-954	188	13	msx1	msx1	PROPN
mkg-954	188	14	in	in	ADP
mkg-954	188	15	human	human	ADJ
mkg-954	188	16	tooth	tooth	NOUN
mkg-954	188	17	agenesis	agenesis	NOUN
mkg-954	188	18	..	..	PUNCT
mkg-954	189	1	j	j	PROPN
mkg-954	189	2	dent	dent	NOUN
mkg-954	189	3	res	re	NOUN
mkg-954	189	4	2002	2002	NUM
mkg-954	189	5	;	;	PUNCT
mkg-954	189	6	81(4	81(4	NUM
mkg-954	189	7	):	):	PUNCT
mkg-954	189	8	274–8	274–8	NUM
mkg-954	189	9	.	.	PUNCT
mkg-954	189	10	14	14	NUM
mkg-954	189	11	.	.	PUNCT
mkg-954	190	1	fekonja	fekonja	PROPN
mkg-954	190	2	a.	a.	PROPN
mkg-954	190	3	hypodontia	hypodontia	PROPN
mkg-954	190	4	in	in	ADP
mkg-954	190	5	orthodontically	orthodontically	ADV
mkg-954	190	6	treated	treat	VERB
mkg-954	190	7	children	child	NOUN
mkg-954	190	8	.	.	PUNCT
mkg-954	191	1	eur	eur	PROPN
mkg-954	191	2	j	j	PROPN
mkg-954	191	3	of	of	ADP
mkg-954	191	4	orthod	orthod	NOUN
mkg-954	191	5	2005	2005	NUM
mkg-954	191	6	;	;	PUNCT
mkg-954	191	7	27	27	NUM
mkg-954	191	8	:	:	PUNCT
mkg-954	191	9	457–60	457–60	NUM
mkg-954	191	10	.	.	PROPN
mkg-954	192	1	15	15	NUM
mkg-954	192	2	.	.	X
mkg-954	193	1	mikkola	mikkola	PROPN
mkg-954	193	2	ml	ml	PROPN
mkg-954	193	3	,	,	PUNCT
mkg-954	193	4	thesleff	thesleff	PROPN
mkg-954	193	5	i.	i.	PROPN
mkg-954	193	6	ectodysplasin	ectodysplasin	PROPN
mkg-954	193	7	signalling	signal	VERB
mkg-954	193	8	in	in	ADP
mkg-954	193	9	development	development	NOUN
mkg-954	193	10	.	.	PUNCT
mkg-954	194	1	cytokine	cytokine	ADJ
mkg-954	194	2	growth	growth	NOUN
mkg-954	194	3	factor	factor	NOUN
mkg-954	194	4	rev	rev	VERB
mkg-954	194	5	2003	2003	NUM
mkg-954	194	6	;	;	PUNCT
mkg-954	194	7	14	14	NUM
mkg-954	194	8	:	:	PUNCT
mkg-954	194	9	211–24	211–24	NUM
mkg-954	194	10	.	.	PUNCT
mkg-954	195	1	16	16	NUM
mkg-954	195	2	.	.	PUNCT
mkg-954	196	1	cobourne	cobourne	PROPN
mkg-954	196	2	mt	mt	PROPN
mkg-954	196	3	,	,	PUNCT
mkg-954	196	4	hardcastle	hardcastle	PROPN
mkg-954	196	5	z	z	PROPN
mkg-954	196	6	,	,	PUNCT
mkg-954	196	7	sharpe	sharpe	PROPN
mkg-954	196	8	pt	pt	PROPN
mkg-954	196	9	.	.	PROPN
mkg-954	196	10	sonic	sonic	ADJ
mkg-954	196	11	hedgehog	hedgehog	PROPN
mkg-954	196	12	regulates	regulate	VERB
mkg-954	196	13	epithelial	epithelial	ADJ
mkg-954	196	14	proliferation	proliferation	NOUN
mkg-954	196	15	and	and	CCONJ
mkg-954	196	16	cell	cell	NOUN
mkg-954	196	17	survival	survival	NOUN
mkg-954	196	18	in	in	ADP
mkg-954	196	19	the	the	DET
mkg-954	196	20	developing	develop	VERB
mkg-954	196	21	tooth	tooth	NOUN
mkg-954	196	22	germ	germ	NOUN
mkg-954	196	23	.	.	PUNCT
mkg-954	197	1	j	j	PROPN
mkg-954	197	2	dent	dent	PROPN
mkg-954	197	3	res	re	NOUN
mkg-954	197	4	2001	2001	NUM
mkg-954	197	5	;	;	PUNCT
mkg-954	197	6	80	80	NUM
mkg-954	197	7	:	:	SYM
mkg-954	197	8	1974–9	1974–9	NUM
mkg-954	197	9	.	.	NOUN
mkg-954	197	10	17	17	NUM
mkg-954	197	11	.	.	PUNCT
mkg-954	197	12	vieira	vieira	PROPN
mkg-954	197	13	ar	ar	PROPN
mkg-954	197	14	,	,	PUNCT
mkg-954	197	15	meira	meira	PROPN
mkg-954	197	16	r	r	PROPN
mkg-954	197	17	,	,	PUNCT
mkg-954	197	18	modesto	modesto	PROPN
mkg-954	197	19	a	a	X
mkg-954	197	20	,	,	PUNCT
mkg-954	198	1	murray	murray	PROPN
mkg-954	198	2	jc	jc	PROPN
mkg-954	198	3	.	.	PROPN
mkg-954	198	4	msx1	msx1	PROPN
mkg-954	198	5	,	,	PUNCT
mkg-954	198	6	pax9	pax9	PROPN
mkg-954	198	7	,	,	PUNCT
mkg-954	198	8	andmsx1	andmsx1	PROPN
mkg-954	198	9	,	,	PUNCT
mkg-954	198	10	pax9	pax9	NOUN
mkg-954	198	11	,	,	PUNCT
mkg-954	198	12	and	and	CCONJ
mkg-954	198	13	tgfa	tgfa	PROPN
mkg-954	198	14	contribute	contribute	VERB
mkg-954	198	15	to	to	ADP
mkg-954	198	16	tooth	tooth	NOUN
mkg-954	198	17	agenesis	agenesis	NOUN
mkg-954	198	18	in	in	ADP
mkg-954	198	19	humans	human	NOUN
mkg-954	198	20	.	.	PUNCT
mkg-954	199	1	j	j	PROPN
mkg-954	199	2	dent	dent	NOUN
mkg-954	199	3	res	re	NOUN
mkg-954	199	4	2004	2004	NUM
mkg-954	199	5	;	;	PUNCT
mkg-954	199	6	83	83	NUM
mkg-954	199	7	:	:	PUNCT
mkg-954	199	8	723–7	723–7	NUM
mkg-954	199	9	.	.	NOUN
mkg-954	200	1	18	18	NUM
mkg-954	200	2	.	.	PUNCT
mkg-954	201	1	trevor	trevor	PROPN
mkg-954	201	2	p	p	PROPN
mkg-954	201	3	,	,	PUNCT
mkg-954	201	4	pemberton	pemberton	PROPN
mkg-954	201	5	j	j	PROPN
mkg-954	201	6	,	,	PUNCT
mkg-954	201	7	gee	gee	PROPN
mkg-954	201	8	j	j	PROPN
mkg-954	201	9	,	,	PUNCT
mkg-954	201	10	pragna	pragna	PROPN
mkg-954	201	11	i.	i.	PROPN
mkg-954	201	12	gene	gene	PROPN
mkg-954	201	13	discovery	discovery	PROPN
mkg-954	201	14	for	for	ADP
mkg-954	201	15	dental	dental	ADJ
mkg-954	201	16	anomalies	anomaly	NOUN
mkg-954	201	17	:	:	PUNCT
mkg-954	201	18	a	a	DET
mkg-954	201	19	primer	primer	NOUN
mkg-954	201	20	for	for	ADP
mkg-954	201	21	the	the	DET
mkg-954	201	22	dental	dental	ADJ
mkg-954	201	23	professional	professional	NOUN
mkg-954	201	24	.	.	PUNCT
mkg-954	202	1	j	j	PROPN
mkg-954	202	2	am	be	AUX
mkg-954	202	3	dent	dent	ADJ
mkg-954	202	4	assoc	assoc	PROPN
mkg-954	202	5	2006	2006	NUM
mkg-954	202	6	;	;	PUNCT
mkg-954	202	7	137	137	NUM
mkg-954	202	8	:	:	PUNCT
mkg-954	202	9	743–52	743–52	NUM
mkg-954	202	10	.	.	NOUN
mkg-954	203	1	19	19	NUM
mkg-954	203	2	.	.	PUNCT
mkg-954	203	3	pereira	pereira	PROPN
mkg-954	203	4	tv	tv	PROPN
mkg-954	203	5	,	,	PUNCT
mkg-954	203	6	salzano	salzano	PROPN
mkg-954	203	7	fm	fm	PROPN
mkg-954	203	8	,	,	PUNCT
mkg-954	203	9	mostowska	mostowska	ADJ
mkg-954	203	10	a.	a.	NOUN
mkg-954	203	11	natural	natural	PROPN
mkg-954	203	12	selection	selection	NOUN
mkg-954	203	13	andpereira	andpereira	PROPN
mkg-954	203	14	tv	tv	PROPN
mkg-954	203	15	,	,	PUNCT
mkg-954	203	16	salzano	salzano	PROPN
mkg-954	203	17	fm	fm	PROPN
mkg-954	203	18	,	,	PUNCT
mkg-954	203	19	mostowska	mostowska	ADJ
mkg-954	203	20	a.	a.	NOUN
mkg-954	203	21	natural	natural	ADJ
mkg-954	203	22	selection	selection	NOUN
mkg-954	203	23	and	and	CCONJ
mkg-954	203	24	molecular	molecular	ADJ
mkg-954	203	25	evolution	evolution	NOUN
mkg-954	203	26	in	in	ADP
mkg-954	203	27	primate	primate	ADJ
mkg-954	203	28	pax9	pax9	NOUN
mkg-954	203	29	gene	gene	NOUN
mkg-954	203	30	,	,	PUNCT
mkg-954	203	31	a	a	DET
mkg-954	203	32	major	major	ADJ
mkg-954	203	33	determinant	determinant	NOUN
mkg-954	203	34	of	of	ADP
mkg-954	203	35	tooth	tooth	NOUN
mkg-954	203	36	development	development	NOUN
mkg-954	203	37	.	.	PUNCT
mkg-954	204	1	proc	proc	PROPN
mkg-954	204	2	natl	natl	PROPN
mkg-954	204	3	acad	acad	PROPN
mkg-954	204	4	sci	sci	PROPN
mkg-954	204	5	usa	usa	PROPN
mkg-954	204	6	2006	2006	NUM
mkg-954	204	7	;	;	PUNCT
mkg-954	204	8	103(15	103(15	NUM
mkg-954	204	9	):	):	PUNCT
mkg-954	204	10	5676–81	5676–81	NUM
mkg-954	204	11	.	.	PROPN
mkg-954	204	12	20	20	NUM
mkg-954	204	13	.	.	PUNCT
mkg-954	205	1	kist	kist	PROPN
mkg-954	205	2	r	r	PROPN
mkg-954	205	3	,	,	PUNCT
mkg-954	205	4	watson	watson	PROPN
mkg-954	205	5	m	m	PROPN
mkg-954	205	6	,	,	PUNCT
mkg-954	205	7	wang	wang	PROPN
mkg-954	205	8	x	x	PROPN
mkg-954	205	9	,	,	PUNCT
mkg-954	205	10	cairns	cairns	PROPN
mkg-954	205	11	p	p	X
mkg-954	205	12	,	,	PUNCT
mkg-954	205	13	miles	mile	NOUN
mkg-954	205	14	c	c	NOUN
mkg-954	205	15	,	,	PUNCT
mkg-954	205	16	reid	reid	PROPN
mkg-954	205	17	dj	dj	PROPN
mkg-954	205	18	,	,	PUNCT
mkg-954	205	19	peters	peters	PROPN
mkg-954	205	20	h.	h.	PROPN
mkg-954	205	21	reduction	reduction	NOUN
mkg-954	205	22	of	of	ADP
mkg-954	205	23	pax9	pax9	NOUN
mkg-954	205	24	gene	gene	NOUN
mkg-954	205	25	dosage	dosage	NOUN
mkg-954	205	26	in	in	ADP
mkg-954	205	27	an	an	DET
mkg-954	205	28	alleli	alleli	ADJ
mkg-954	205	29	series	series	NOUN
mkg-954	205	30	of	of	ADP
mkg-954	205	31	mouse	mouse	NOUN
mkg-954	205	32	mutant	mutant	NOUN
mkg-954	205	33	causes	cause	VERB
mkg-954	205	34	hypodontia	hypodontia	NOUN
mkg-954	205	35	and	and	CCONJ
mkg-954	205	36	oligodontia	oligodontia	PROPN
mkg-954	205	37	.	.	PUNCT
mkg-954	206	1	hum	hum	PROPN
mkg-954	206	2	mol	mol	ADP
mkg-954	206	3	genet	genet	PROPN
mkg-954	206	4	2005	2005	NUM
mkg-954	206	5	;	;	PUNCT
mkg-954	206	6	11	11	NUM
mkg-954	206	7	:	:	PUNCT
mkg-954	206	8	181–90	181–90	NUM
mkg-954	206	9	.	.	X
mkg-954	207	1	21	21	NUM
mkg-954	207	2	.	.	PUNCT
mkg-954	208	1	lammi	lammi	PROPN
mkg-954	208	2	,	,	PUNCT
mkg-954	208	3	halonenk	halonenk	PROPN
mkg-954	208	4	,	,	PUNCT
mkg-954	208	5	pirinen	pirinen	NOUN
mkg-954	208	6	s	s	PROPN
mkg-954	208	7	,	,	PUNCT
mkg-954	208	8	thesleff	thesleff	PROPN
mkg-954	208	9	i	i	PROPN
mkg-954	208	10	,	,	PUNCT
mkg-954	208	11	arte	arte	PROPN
mkg-954	208	12	s	s	PROPN
mkg-954	208	13	,	,	PUNCT
mkg-954	208	14	nieminen	nieminen	PROPN
mkg-954	208	15	p.	p.	PROPN
mkg-954	208	16	a	a	DET
mkg-954	208	17	missense	missense	NOUN
mkg-954	208	18	mutation	mutation	NOUN
mkg-954	208	19	in	in	ADP
mkg-954	208	20	pax9	pax9	NOUN
mkg-954	208	21	in	in	ADP
mkg-954	208	22	a	a	DET
mkg-954	208	23	family	family	NOUN
mkg-954	208	24	with	with	ADP
mkg-954	208	25	distinct	distinct	ADJ
mkg-954	208	26	phenotype	phenotype	NOUN
mkg-954	208	27	of	of	ADP
mkg-954	208	28	oligodontia	oligodontia	PROPN
mkg-954	208	29	.	.	PUNCT
mkg-954	209	1	eur	eur	PROPN
mkg-954	209	2	j	j	PROPN
mkg-954	209	3	hum	hum	PROPN
mkg-954	209	4	genet	genet	PROPN
mkg-954	209	5	2003	2003	NUM
mkg-954	209	6	;	;	PUNCT
mkg-954	209	7	11	11	NUM
mkg-954	209	8	:	:	PUNCT
mkg-954	209	9	866–71	866–71	NUM
mkg-954	209	10	.	.	PUNCT
mkg-954	210	1	22	22	NUM
mkg-954	210	2	.	.	PUNCT
mkg-954	211	1	nieminen	nieminen	PROPN
mkg-954	211	2	p	p	PROPN
mkg-954	211	3	,	,	PUNCT
mkg-954	211	4	arte	arte	PROPN
mkg-954	211	5	s	s	PROPN
mkg-954	211	6	,	,	PUNCT
mkg-954	211	7	tanner	tanner	NOUN
mkg-954	211	8	d	d	NOUN
mkg-954	211	9	,	,	PUNCT
mkg-954	211	10	paulin	paulin	PROPN
mkg-954	211	11	l	l	PROPN
mkg-954	211	12	,	,	PUNCT
mkg-954	211	13	alaluusas	alaluusa	NOUN
mkg-954	211	14	,	,	PUNCT
mkg-954	211	15	thesleff	thesleff	NOUN
mkg-954	211	16	i	i	PROPN
mkg-954	211	17	,	,	PUNCT
mkg-954	211	18	pirinen	pirinen	PROPN
mkg-954	211	19	s.	s.	PROPN
mkg-954	211	20	identification	identification	NOUN
mkg-954	211	21	of	of	ADP
mkg-954	211	22	a	a	DET
mkg-954	211	23	nonsense	nonsense	NOUN
mkg-954	211	24	mutation	mutation	NOUN
mkg-954	211	25	in	in	ADP
mkg-954	211	26	the	the	DET
mkg-954	211	27	msx1	msx1	PROPN
mkg-954	211	28	and	and	CCONJ
mkg-954	211	29	pax9	pax9	NOUN
mkg-954	211	30	gene	gene	NOUN
mkg-954	211	31	in	in	ADP
mkg-954	211	32	molar	molar	ADJ
mkg-954	211	33	oligodontia	oligodontia	ADP
mkg-954	211	34	.	.	PUNCT
mkg-954	212	1	eur	eur	PROPN
mkg-954	212	2	j	j	PROPN
mkg-954	212	3	hum	hum	PROPN
mkg-954	212	4	genet	genet	PROPN
mkg-954	212	5	.	.	PUNCT
mkg-954	213	1	2001	2001	NUM
mkg-954	213	2	;	;	PUNCT
mkg-954	213	3	9	9	NUM
mkg-954	213	4	:	:	SYM
mkg-954	213	5	743–6	743–6	NUM
mkg-954	213	6	.	.	NOUN
mkg-954	213	7	23	23	NUM
mkg-954	213	8	.	.	PUNCT
mkg-954	214	1	thesleff	thesleff	PROPN
mkg-954	214	2	i.	i.	PROPN
mkg-954	214	3	the	the	DET
mkg-954	214	4	genetic	genetic	ADJ
mkg-954	214	5	basis	basis	NOUN
mkg-954	214	6	of	of	ADP
mkg-954	214	7	tooth	tooth	NOUN
mkg-954	214	8	development	development	NOUN
mkg-954	214	9	and	and	CCONJ
mkg-954	214	10	dental	dental	ADJ
mkg-954	214	11	defects	defect	NOUN
mkg-954	214	12	.	.	PUNCT
mkg-954	215	1	am	be	AUX
mkg-954	215	2	j	j	PROPN
mkg-954	215	3	med	med	PROPN
mkg-954	215	4	genet	genet	PROPN
mkg-954	215	5	2006	2006	NUM
mkg-954	215	6	;	;	PUNCT
mkg-954	215	7	140	140	NUM
mkg-954	215	8	:	:	PUNCT
mkg-954	215	9	2530–5	2530–5	NUM
mkg-954	215	10	.	.	PUNCT