id	author	title	date	pages	extension	mime	words	sentence	flesch	summary	cache	txt
cord-322332-0pi3wcv5	Conforti, Claudio	Doxycycline, a widely used antibiotic in dermatology with a possible anti‐inflammatory action against IL‐6 in COVID‐19 outbreak	2020-05-15		.txt	text/plain	511	20	28	In fact, in addition to its well-defined antibiotic effects (bacteriostatic action by inhibition of bacterial protein synthesis), in vitro studies have shown doxycycline to exert anti-inflammatory effects at low (20-40 mg/day) and high (100 or 200 mg/day) doses with inhibitory action on metalloproteases and modulating effects of pro-inflammatory cytokines IL-6, IL-8, and tumor necrosis factor-alpha. Thereby, low doxycycline doses have been shown to be more effective than high doses to prevent induction of pro-inflammatory cytokines (such as IL-6) in inflammatory diseases.	cache/cord-322332-0pi3wcv5.txt	txt/cord-322332-0pi3wcv5.txt
