Dermatology: Practical and Conceptual Editorial | Dermatol Pract Concept 2020;10(3):e2020068 1 Dermatology Practical & Conceptual Introduction In the context of this editorial on congenital melanocytic nevi (CMN), the following points will be discussed: 1. Medium and large CMN are hamartomas present at birth, but many small CMN can appear later, within the first decade of life. 2. Most CMN of any size will persist throughout a lifetime, but some, especially those located on special areas, includ- ing nails and acral sites, might disappear as a result of spontaneous involution. 3. If there is any precursor lesion of melanoma, then CMN is entitled to be the most important one. The CMN Family Traditionally, CMN are classified into 2 groups, namely, CMN blue type and CMN non-blue type [1]. Of the first group, blue nevi are the most frequent ones (Figure 1, A and B); other dermal melanocytoses belonging to this group of CMN include mongolian spot, nevus of Ota, and nevus of Ito (Figure 1, C and D). CMN of the non-blue family are also defined as super- ficial CMN to point out the main difference from blue-type CMN, which are typified by a more deeply situated pro- liferation of dendritic melanocytes. Superficial CMN are traditionally subdivided into the following 3 groups based on the diameter they are expected to attain in adulthood: small CMN, <2 cm; medium CMN, 2-20 cm; and large CMN, >20 cm. This subdivision is arbitrary, but it is based on the fact that the risk for melanoma increases with the increasing size of CMN. Medium and large CMN are hamartomas typified by a benign proliferation of melanocytes and keratinocytes [2,3]. They are always present at birth, whereas small CMN can frequently appear later, usually before puberty [3]. These nevi are commonly classified as early acquired melanocytic nevi (AMN), but in our estimation they essentially belong to the family of CMN. This is mainly based on their similarity to “true congenital” melanocytic nevi in terms of morphological features and evolutional behavior (Figure 2). Reassessing the Biological Significance of Congenital Melanocytic Nevi Giuseppe Argenziano,1 Stefano Caccavale,1 Gabriella Brancaccio,1 Elvira Moscarella,1 Vincenzo Piccolo,1 Aimilios Lallas2 1 Dermatology Unit, University of Campania, Naples, Italy 2 First Department of Dermatology, Aristotle University, Thessaloniki, Greece Key words: Citation: Argenziano G, Caccavale S, Brancaccio G, Moscarella E, Piccolo V, Lallas A. Reassessing the biological significance of congenital melanocytic nevi. Dermatol Pract Concept. 2020;10(3):e2020068. DOI: https://doi.org/10.5826/dpc.1003a68 Accepted: June 29, 2020; Published: July 9, 2020 Copyright: ©2020 Argenziano et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Funding: None. Competing interests: The authors have no conflicts of interest to disclose. Authorship: All authors have contributed significantly to this publication. Corresponding author: Giuseppe Argenziano, MD, Dermatology Unit, University of Campania, Nuovo Policlinico ed 9C, Via Pansini 5, 80131 Naples, Italy. Email: editor@dpcj.org https://doi.org/10.5826/dpc.1003a68 mailto:editor@dpcj.org 2 Editorial | Dermatol Pract Concept 2020;10(3):e2020068 which tends to become stable as soon as the globules disappear [3-5]. Over a variable period of time, usually years, small CMN become more elevated and acquire a papillomatous (usually on the trunk) (Figure 4) or smooth (usu- ally on the face) surface. Dermoscopi- cally, brown globules at the periphery disappear, while a cobblestone pattern becomes visible throughout the lesion. In medium and large CMN, the keratinocytic proliferation is usually seen as a verrucous surface intermingled with terminal hairs. Dermoscopically, medium and large CMN may exhibit a globular pattern, a reticular pattern, or a combination of both (Figure 5). Most large CMN are confined to the skin, but in rare cases they may involve the central nervous system configuring the so-called neurocutaneous melano- sis. This is a potentially life-threatening condition that usually occurs when a large CMN is accompanied by multiple moscopically typified by a globular pat- tern (Figure 3). The presence of brown globules at the periphery is the hall- mark of the growing phase of the lesion, Morphologically, most small CMN (either present at birth or appearing in early childhood) are clinically flat or slightly raised pigmented lesions der- Figure 1. (A,B) Clinical and dermoscopic images of a blue nevus. (C,D) Nevus of Ito on the shoulder of a young boy. Figure 2. A 10-year-old girl with multiple nevi. Based on the history, the only “true” congenital melanocytic nevus (CMN) is the one depicted in (B), whereas the other nevi shown (C-I) appeared within the first 2-3 years of life. However, based on morphology, all of them show a globular pattern; thus the hypothesis is that all these nevi belong to the same spectrum of lesions, namely, CMN. Editorial | Dermatol Pract Concept 2020;10(3):e2020068 3 assessing this risk included medium and large CMN [17-21]. In one of the larg- est studies of more than 6,500 patients with medium and large CMN, 0.7% of patients developed melanoma at a median age of 7 years [22]. However, the risk of developing melanoma was by far highest in CMN 40 cm or more CMN and Melanoma Risk The dogmatic knowledge about the risk of melanoma in CMN states that the larger the nevus, the higher the chance of melanoma development within a preexisting CMN. Most of the studies smaller CMN (satellitosis) and mostly in bathing trunk nevi (Figure 6) [6]. In this clinical context a brain nuclear magnetic resonance is usually indicated within the first year of life [7]. The Life Cycle of CMN As mentioned above, small CMN usu- ally tend to persist over time. Especially when located on the head-neck, trunk, and limbs, small CMN undergo pro- gressive maturation within the dermis, thus evolving into intradermal nevi. In our estimation, the great majority of dermal melanocytic nevi in adulthood belong to the group of small CMN. This is because most of AMN do not show a tendency to maturation. They appear usually after puberty as a superficial, junctional, or compound proliferation of melanocytes, growing for a variable period of time and finally going through spontaneous involution [8,9]. Although most small CMN tend to persist over time, there are instances in which CMN are prone to disappear. This is particularly the case in special areas including nails (Figure 7) and acral sites where CMN may undergo sponta- neous involution after a variable period of time, usually years [10-14]. It is unknown why some CMN undergo maturation and some disap- pear. A possible explanation might be related to the depth level of the skin in which the nevus is mainly prolifer- ating. CMN of the head-neck region, trunk, and limbs are usually compound nevi histopathologically, whereas CMN of the nails and acral sites are more of the junctional type [15]. It is possible that dermal melanocytes may tend to undergo maturation while epidermal melanocytes are more prone to disap- pear after a variable period of time, similarly to AMN. The latter are also typified by a junctional proliferation of melanocytes and they also usually undergo spontaneous involution over time [10-16]. Figure 3. Small congenital melanocytic nevi dermoscopically typified by a globular pattern. Figure 4. (A,B) Clinical and dermoscopic images of a dermal congenital melanocytic nevus on the trunk with its papillomatous surface. Figure 5. (A) Intermediate size congenital melanocytic nevus (CMN) with its verrucous sur- face intermingled with terminal hairs. Dermoscopically, medium and large CMN may exhibit (B) a globular pattern, (C) a reticular pattern, or (D) a combination of both. 4 Editorial | Dermatol Pract Concept 2020;10(3):e2020068 in diameter. In the latter group, the risk may reach 10% [22]. If we compare these percentages to the risk of mela- noma within an AMN (recently calcu- lated as approximately 1 out of 200,000 AMN) [23], we can conclude that CMN is by far the most important melanoma precursor. Melanoma risk in small CMN has not yet been calculated, perhaps because of the limitations in discriminating between small CMN and AMN. In a recent study by our group, however, we reported that at our institution most of the melanomas arising within a CMN (78%) were developing in the context of a small CMN (unpublished data). This seems paradoxical, but it can be easily explained by the respective numbers of small, medium, and large CMN seen in routine practice. Assuming that the risk of melanoma in a large CMN is 10%, we have to screen 10 large CMN to find 1 melanoma. In our institution, we screen a mean of 2 new patients with large CMN per year; thus we need 5 years to find 1 melanoma. Assuming that the risk of melanoma in a small CMN is much lower than 10%, still the chance of finding one is much higher Figure 6. A boy with a giant congenital melanocytic nevus (CMN) associated with multiple smaller CMN (satellitosis). Figure 7. (A,B) Clinical and dermoscopic images of a congenital melanocytic nevus of the nail matrix, undergoing spontaneous involution after 2 years (C,D). Editorial | Dermatol Pract Concept 2020;10(3):e2020068 5 benignity: a case series. Pediatr Derma- tol. 2019;36(2):227-231. https://doi. org/10.1111/pde.13745 5. Odorici G, Longhitano S, Kaleci S, et al. Morphology of congenital nevi in dermoscopy and reflectance confocal mi- croscopy according to age: a pilot study. J Eur Acad Dermatol Venereol. Published online ahead of print, 2020 Apr 10. https://doi.org/10.1111/jdv.16448 6. Alikhan A, Ibrahimi OA, Eisen DB. Congenital melanocytic nevi: where are we now? Part I: clinical presentation, epidemiology, pathogenesis, histology, malignant transformation, and neurocu- taneous melanosis. J Am Acad Derma- tol. 2012;67(4):495.e1-514; quiz 512- 514. https://doi.org/10.1016/j.jaad.2 012.06.023 7. Kinsler VA, Aylett SE, Coley SC, Chong WK, Atherton DJ. Central nervous system imaging and congenital melanocytic nae- vi. Arch Dis Child. 2001;84(2):152-155. https://doi.org/10.1136/adc.84.2.152 8. Vezzoni R, Conforti C, Vichi S, et al. Is there more than one road to nevus-asso- ciated melanoma? Dermatol Pract Con- cept. 2020;10(2):e2020028. https://doi. org/10.5826/dpc.1002a28 9. Pizzichetta MA, Massone C, Grandi G, Pelizzo G, Soyer HP. Morphologic changes of acquired melanocytic nevi with eccentric foci of hyperpigmentation (“Bolognia sign”) assessed by dermos- copy. Arch Dermatol. 2006;142(4):479- 483. https://doi.org/10.1001/archderm. 142.4.479 10. Haenssle HA, Blum A, Hofmann-Wel- lenhof R, et al. When all you have is a dermatoscope—start looking at the nails. Dermatol Pract Concept. 2014;4(4):11- 20. https://doi.org/10.5826/dpc.0404a02 11. Marghoob AA. Congenital melanocytic nevi: evaluation and management. Derma- tol Clin. 2002;20(4):607-616. https://doi. org/10.1016/S0733-8635(02)00030-X 12. Strauss RM, Newton Bishop JA. Sponta- neous involution of congenital melano- cytic nevi of the scalp. J Am Acad Der- matol. 2008;58(3):508-511. https://doi. org/10.1016/j.jaad.2006.05.076 13. Lee NR, Chung HC, Hong H, Lee JW, Ahn SK. Spontaneous involution of congenital melanocytic nevus with halo phenomenon. Am J Dermatopathol. 2015;37(12):e137-e139. https://doi. org/10.1097/DAD.0000000000000311 14. Nath AK, Thappa DM, Rajesh NG. Spon- taneous regression of a congenital mela- nocytic nevus. Indian J Dermatol Vene- more common than usually reported because early AMN might also belong to the group of CMN. They can persist or disappear based on their localiza- tion on different body areas and, much more frequently than AMN, they can be found in association with melanoma, in both children and adults. Small CMN, although traditionally considered as not requiring special attention, might be the most frequent melanoma precursor in terms of absolute numbers. This does not mean that the risk of melanoma on small CMN is high, but that the majority of nevi on which melanoma develops belong to the category of small CMN [25]. References 1. Moscarella E, Piccolo V, Argenziano G, et al. Problematic lesions in chil- dren. Dermatol Clin. 2013;31(4):535- 547, vii. https://doi.org/10.1016/j.det. 2013.06.003 2. Schaffer JV. Update on melanocyt- ic nevi in children. Clin Dermatol. 2015;33(3):368-386. https://doi.org/ 10.1016/j.clindermatol.2014.12.015 3. Errichetti E, Patriarca MM, Stinco G. Dermoscopy of congenital melanocyt- ic nevi: a ten-year follow-up study and comparative analysis with acquired me- lanocytic nevi arising in prepubertal age. Eur J Dermatol. 2017;27(5):505-510. https://doi.org/10.1684/ejd.2017.3088 4. Cotton CH, Goldberg GN. Evolution of congenital melanocytic nevi toward because of the much higher incidence of small CMN in the clinical routine. Pediatric melanoma is, in general, an extremely rare disease. In a recent systematic review, we found 2 important issues to mention (unpublished data). First, the majority (about 55%) of pedi- atric melanomas (defined as melanoma occurring in patients aged 18 years or less) develop as CMN-associated mel- anoma (Figure 8). This is in contrast to what is happening in adults, in whom at least 70% of melanomas arise de novo. The second is related to the mortality for pediatric melanoma, which is higher for nevus-associated melanoma than for de novo melanoma, especially for chil- dren within the first decade of life. This difference was not attributed to Breslow thickness, which was similar in both groups. Thus, the only possible explana- tion is that at least a certain percentage of lesions that were reported as de novo melanoma were instead benign melano- cytic tumors. This underlines once more the problem of morphologically difficult lesions in children, as already reported by Leman et al [24]. If this is true, then the percentage of pediatric melanomas that develop on CMN is even higher than 55%. Conclusions CMN are much more relevant lesions than previously considered. They are Figure 8. 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