Dermatology: Practical and Conceptual Research Letter | Dermatol Pract Concept. 2022;12(2):e2022060 1 Dermoscopic Features of Amelanotic and Hypomelanotic Melanomas: a Review of 49 Cases Sarah Dawood1, Alla Altayeb1, Ausama Atwan1, Caroline Mills1 1 St Woolos Hospital, Dermatology department, Newport, United Kingdom. Key words: Hypomelanotic melanoma, amelanotic melanoma, dermatoscopy, dermoscopy, skin cancer Citation: Dawood S, Altayeb A, Atwan A, Mills C. Dermoscopic features of Amelanotic and Hypomelanotic Melanomas: A review of 49 cases. Dermatol Pract Concept. 2022;12(2):e2022060. DOI: https://doi.org/10.5826/dpc.1202a60 Accepted: October 21, 2021; Published: April 2022 Copyright: ©2022 Dawood et al. This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial License (BY-NC-4.0), https://creativecommons.org/licenses/by-nc/4.0/, which permits unrestricted noncommercial use, distribution, and reproduction in any medium, provided the original authors and source are credited. Funding: None. Competing interests: None. Authorship: All authors have contributed significantly to this publication. Corresponding author: Dr Sarah Dawood, St Woolos Hospital Dermatology 131 Stow Hill, Newport NP20 4SZ, United Kingdom. E-mail: sarahamrd@live.co.uk Introduction Amelanotic and hypomelanotic melanomas (AHM) represent 2-8% of all melanomas. They are often diagnosed late due to the lack of a distinctive clinical appearance. As a result, AHM is associated with higher mortality compared with pig- mented melanomas. It is, therefore, crucial to be aware of the dermoscopic features of such lesions to aid early diagnosis. Case Presentation During a 6-year period (2014-2019), a total of 165 melanoma cases were diagnosed via our teledermoscopy service, using Nikon D300S camera and Heine® Delta 20T dermatoscope. Of those, 49 cases (29.7%) were AHM, including 27 males and 22 females with a median age of 68 years (range 16-87 years). Most AMH were on the upper limbs (20 patients) and the trunk (13 patients). The rest were on the lower limbs (9 patients), and head and neck (7 patients). Most lesions (n = 46, 83.8%) were invasive AHM ( superficial spreading = 27; nodular = 14; desmoplastic melanoma = 3; lentigomaligna melanoma = 2). The remaining 3 lesions were in situ AHM. The median Breslow thickness of AHM was higher than pigmented MM (AHM = 1.7 mm interquartile range [IQR] = 3.50) versus 0.98 mm (IQR = 1.23) for pigmented MM). Short white lines (Figure 1B) and milky-red areas ( Figure 2B) were the most common dermoscopic findings in our cohort of AHM, observed in 39 lesions (79.6%) and 33 lesions (67.3%), respectively. Milky-red areas were present in similar frequencies in lesions ≤ 1 mm in thickness (70%) and lesions > 1 mm in thickness (63.9%) (Table 1). In our study, 63.3% of AHM had more than one vascu- lar pattern (Table 1). Dotted, linear, and looped vessels were present in 57.1%, 63.2%, and 63.3% of lesions, respectively. Dotted vessels were seen in 90% of AHM of < 1mm, com- pared with 44.4% of AHM of > 1mm.  Remnant pigment was present in 27 lesions (55.1%), and present in 70% of lesions ≤ 1mm in thickness and 50% of lesions > 1 mm in thickness. Gray granular structures and la- cunae were less frequently seen, found in 44.9% and 26.5% of lesions, respectively.  2 Research Letter | Dermatol Pract Concept. 2022;12(2):e2022060 Discussion Short white lines were the most common finding in our co- hort, seen in 79.6% of cases. This is higher than reported observations at 30.8% [1]. We assume reviewing magnified images on the monitor contributed to better visualization of these subtle features. The incidence of milky-red areas in our study (67.3%) was close to the incidence reported in the literature at 54.5% [2,3]. Also, polymorphic vessels, an important distinguishing feature in AHM, were present in over 50% of our AHM cases. Dotted vessels were present in nearly half of our cases. This was similar to the incident reported in the literature [1]). Zalaudeket al reported a strong association between Figure 2. (A) Lesion on the lower leg of a 57-year-old woman. A confirmed melanoma with Breslow thickness of 3 mm. (B) Dermoscopy shows irregularly distributed dotted vessels (arrows), a milky red area (star), and a subtle remnant of pigment at the periphery. Figure 1. (A) Lesion on the forearm of a 46-year-old woman. A confirmed melanoma with Breslow thickness of 1.1 mm. (B) Dermoscopy shows dotted (black arrows) and looped (white arrows) vessels, milky red areas (stars), and white structures (long arrows). Research Letter | Dermatol Pract Concept. 2022;12(2):e2022060 3 dotted vessels and AHM with Breslow thickness less than 1 mm [4]. Our study supports this observation. Conclusions Our study reinforces the findings that polymorphic vessels and milky-red areas are common features of AHM. In ad- dition, our study indicates that short white lines are also common and helpful predictive feature. Clinicians should be aware of these dermoscopic findings when non-specific lesions are encountered. Acknowledgement We thank the Medical Illustration Department at Aneurin Bevan University Health Board for providing the telederma- tology service. References 1. Paolino G, Bearzi P, Pampena R, et al. Clinicopathological and dermoscopic features of amelanotic and hypomelanotic melanoma: a retrospective multicentric study. Int J Dermatol. 2020;59(11):1371-1380. DOI: 10.1111/ijd.15064. PMID: 32726478. 2. Pizzichetta MA, Talamini R, Stanganelli I, et al. Amelanotic/ hypomelanotic melanoma: clinical and dermoscopic features. Br J Dermatol. 2004;150(6):1117-1124. DOI: 10.1111/j.1365- 2133.2004.05928.x. PMID: 15214897. 3. Lin MJ, Xie C, Pan Y, Jalilian C, Kelly JW. Dermoscopy improves diagnostic accuracy for clinically amelanotic nodules. Australas J Dermatol. 2019;60(1):45-49. DOI: 10.1111/ajd.12902. PMID: 30123971. 4. Zalaudek I, Kreusch J, Giacomel J, Ferrara G, Catricalà C, Argen- ziano G. How to diagnose nonpigmented skin tumors: a review of vascular structures seen with dermoscopy: part I. Melanocytic skin tumors J Am Acad Dermatol. 2010;63(3):361-374. DOI: 10.1016/j.jaad.2009.11.698. PMID: 20708469. Table 1. Dermoscopic features of Amelanotic and hypomelanotic melanoma in our study Dermoscopic criteria AHM ≤ 1mm in thickness (n = 10) AHM > 1 mm in thickness (n = 36) AHM in situ (n = 3) Total AHM (n = 49) n % n % n % n % Dotted vessels 9 90.0 16 44.4 3 100 28 57.1 Linear vessels 5 50.0 23 63.9 3 100 31 63.2 Looped vessels 3 30.0 26 72.2 2 66.7 31 63.3 Granular structures 5 50.0 16 44.4 1 33.3 22 44.9 Short white lines 8 80.0 28 77.8 3 100 39 79.6 Lacuna structures 3 30.0 10 27.8 0 0 13 26.5 Milky-red areas 7 70.0 23 63.9 3 100 33 67.3 Remnant pigment 7 70.0 18 50.0 2 66.7 27 55.1 Polymorphous vessels 6 60.0 22 61.1 3 100 31 63.2 AHM = amelanotic and hypomelanotic melanomas.