Dermatology: Practical and Conceptual Research Letter | Dermatol Pract Concept. 2022;12(3):e2022111 1 Dermatology Practical & Conceptual Dermoscopy Performs an Important Role to Diagnose Radiation-induced Angiosarcoma on the Breast Gabriel Tagata Seleri1, Marina Riedi Guilherme1, Ana Lúcia de Oliveira Prestes1, Cássio Rafael Moreira1 1 Department of dermatology, Municipal Health Authority of Apucarana, Paraná, Brazil Keywords: angiosarcoma, radiotherapy, oncology, dermoscopy Citation: Seleri GT, Guilherme MR, Prestes ALDO, Moreira CR. Dermoscopy performs an important role to diagnose radiation-induced angiosarcoma on the breast. Dermatol Pract Concept. 2022;12(3):e2022111. DOI: https://doi.org/10.5826/dpc.1203a111 Accepted: November 8, 2021; Published: July 2022 Copyright: ©2022 Seleri et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License (BY-NC-4.0), https://creativecommons.org/licenses/by-nc/4.0/ which permits unrestricted noncommercial use, distribution, and reproduction in any medium, provided the original authors and source are credited. Funding: None. Competing interests: None. Authorship: All authors have contributed significantly to this publication. Corresponding author: Cássio Rafael Moreira, Miguel Simião, 69, Apucarana, Paraná, Brazil E-mail: cassiorafamoreira@gmail.com Introduction Radiation-induced angiosarcoma (RIAS) is a rare subtype of angiosarcoma that originates from endothelial cells exposed to radiation. The breast is the most common location of this condition, and the incidence of RIAS on women treated with breast-conserving surgery and radiotherapy vary from 0.14% to 0.5%, depending upon the study. Prognosis is poor, recurrences are common, distant metastasis may occur, 5-year survival rates are between 28%-54% [1]. On early stages it usually presents itself as painless blue- red patches on a previously irradiated skin area, that pro- gresses to red or violaceus plaques and eventually irregular borders with a nodular appearance. Differential diagnosis includes hematomas, hemangiomas, cellulitis, radiodermitis or atypical vessel lesions. Biopsy is the most accurate method for the diagnosis. This is a case report of RIAS on the breast, with relevant clinical and dermoscopic features. Case Presentation A 68-year-old Caucasian woman presented with a 3 cm, asymptomatic violaceus plaque on the areola of her right breast (Figure 1A), 8 years after radiotherapy for the treat- ment of an invasive ductal carcinoma on the same location. Dermoscopy showed a central hemorrhagic crust, sur- rounded by a purple background, with blue-red globules and shiny-white structures (Figure 1B). Histopathological exam- ination with the presence of spindle cells proliferation, form- ing bundles and compact nodules in the dermis, alongside positive immunohistochemistry for Ki-67 and CD34 mark- ers, confirmed well-differentiated angiosarcoma (Figure 2). Conclusions Diagnostic of incipient radiation-induced angiosarcoma is difficult due to the ample differential diagnosis and non-specific characteristics of this neoplasm. Although none 2 Research Letter | Dermatol Pract Concept. 2022;12(3):e2022111 Figure 1. (A) Clinical photo showing a violaceous plaque, with irregular borders on the areola. (B) Dermoscopy (DermLite DL4, x10) with purple background, red globules, hemorrhagic crust and shiny white structures. Figure 2. (A) Histopathological features showing proliferation of spindle cells, arranged in a lobular pattern on the dermis and extravasated red blood cells (H&E, x10). (B) Spindle cells pleomorphism and cellular atypia (H&E, x40). Immunohistochemical staining with positive CD34 marker (C) and Ki-67 marker (D) on the tumor cells, confirming its endothelial origin and high proliferation activity, respectively. Research Letter | Dermatol Pract Concept. 2022;12(3):e2022111 3 are pathognomonic of RIAS, dermoscopic patterns are im- portant to establish the vascular origin of the lesion, and can help in the differential diagnosis with other vascular tumors that already have dermoscopic features known as angioker- atoma and Kaposi sarcoma [2]. In the present case, dermoscopic findings corroborate those of past reviews, such as variable red, blue or purple structureless areas, white lines and globules most visible on the periphery, reaffirming these as important characteristics in the diagnostic of RIAS [3]. In conclusion, the clinical history of previous radiation therapy associated with dermoscopic findings provides a high suspicion of RIAS, which means that incisional biopsy should be performed early for the correct diagnosis and rapid treatment. References 1. Bonito FJ, de Almeida Cerejeira D, Dahlstedt-Ferreira C, Oliveira Coelho H, Rosas R. Radiation-induced angiosarcoma of the breast: A review. Breast J. 2020;26(3):458–63. DOI: 10.1111/ tbj.13504. PMID: 31448482. 2. Jaimes N, Chen L, Dusza SW, et al. Clinical and dermoscopic characteristics of desmoplastic melanomas. JAMA Dermatol. 2013;149(8):973–974. DOI: 10.1001/jamadermatol.2013.2248 PMID: 23325288 3. Figueroa-Silva O, Argenziano G, Lallas A, Longo C, Piana S, Moscarella E. Dermoscopic pattern of radiation-induced angio- sarcoma (RIA). J Am Acad Dermatol. 2015;73(2):e51-e55. DOI: 10.1016/j.jaad.2015.04.054. PMID: 26183996.