Untitled Observation | Dermatol Pract Concept 2015;5(4):11 43 DERMATOLOGY PRACTICAL & CONCEPTUAL www.derm101.com Case presentation Three female patients (62, 64 and 63 years old) presented with similar chronic multiple facial papules. The patients stated that the lesions aggravated in summer and upon physi- cal exertion and regressed in cold weather. Dermatological examination revealed multiple cystic bluish-skin colored papules on bilateral cheeks (Figure 1A-C). Non-polarized dermoscopic examination revealed well- demarcated papules characterized by a homogeneous bluish- purplish central area surrounded by a pale halo (Figure 1D-F). Histopathological examination revealed dermal cysts containing clear fluid, lined by two layers of cuboidal epi- thelium, which was consistent with the diagnosis of eccrine hidrocystoma (Figure 2). Pale halo surrounding a homogeneous bluish-purplish central area: dermoscopic clue for eccrine hidrocystoma Nilay Duman1, Deniz Duman2, Sedef Sahin2 1 Afyon Kocatepe University, School of Medicine, Department of Dermatology, Afyonkarahisar, Turkey 2 Acibadem University, School of Medicine, Department of Dermatology, Istanbul, Turkey Key words: eccrine hidrocystoma, dermoscopy Citation: Duman N, Duman D, Sahin S. Pale halo surrounding a homogenous bluish-purplish central area: dermoscopic clue for eccrine hidrocystoma. Dermatol Pract Concept 2015;5(4):11. doi: 10.5826/dpc.0504a11 Received: May 28, 2015; Accepted: July 13, 2015; Published: October 31, 2015 Copyright: ©2015 Duman et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Funding: None. Competing interests: The authors have no conflicts of interest to disclose. All authors have contributed significantly to this publication. Corresponding author: Nilay Duman, MD, Assistant Professor, Afyon Kocatepe, University, School of Medicine, Department of Dermatology, Ali Çetinkaya Kampusü, Izmir Karayolu 7. Km, Afyonkarahisar, Turkey. Tel. +902724440304; Fax. +902722463322. Email: nilybayram@hotmail.com Eccrine hidrocystomas are benign tumors of the sweat glands that arise from cystic dilatation of the excretory sweat duct. Exact diagnosis requires biopsy and histopathologic examination, from which arises risk of scarring. Dermoscopy could be a useful tool in diagnosing eccrine hidrocystomas. Herein we aim to present dermoscopic features in three female patients with multiple lesions on the face con- sistent with eccrine hidrocystomas. ABSTRACT 44 Observation | Dermatol Pract Concept 2015;5(4):11 Conclusion Eccrine hidrocystomas are benign tumors of the sweat glands that arise from cystic dilatation of the excretory sweat duct [1]. They typically present as multiple skin-colored to blu- ish cystic papules in the centrofacial area and are most commonly seen in middle-aged women [1]. Aggravation in summer, in humid environments, during exercise and other conditions that involve intense sweating is characteristic for eccrine hidrocytomas [1]. Exact diagnosis requires biopsy and histopathologic examination, from which arises risk of scarring. Considering that the patient is usually female and the localization is the central face, this is of great cosmetic concern to the patient. The number of publications about dermoscopic fea- tures of hidrocystomas is limited in literature. Previously, Zaballos et al. reported that a skin-colored, pink, yellow or blue homogeneous area that occupies the whole lesion with arborizing vessels is the most common dermoscopic pattern associated with apocrine hidrocystomas [2]. Correia et al. defined dermoscopic features of eccrine hidrocystomas as well-demarcated, vessel-free cystic lesions [1]. In our cases, dermoscopic examination showed well-demarcated lesions with a homogeneous bluish-purplish central area surrounded by a characteristic pale halo. The primary differential diagnosis of multiple eccrine hidrocystomas on the face includes eruptive vellus hair cysts, comedonal acne, eruptive syringomas, multiple pilomatrico- Figure 1. Multiple eccrine hidrocystomas. Cystic bluish-skin colored papules on the face (A-C) characterized with well demarcated homoge- neous bluish-purplish central areas surrounded by pale halo on dermoscopy (D-F) using a Heine Delta 20 plus nonpolarized dermatoscope (Heine Optotechnik, Herrsching, Germany; original magnification: × 10). [Copyright: ©2015 Duman et al.] Figure 2. Eccrine hidrocystoma. Dermal cysts containing clear fluid, lined by two layers of cuboidal epithelium (hematoxylin & eosin × 40). [Copyright: ©2015 Duman et al.] Observation | Dermatol Pract Concept 2015;5(4):11 45 References 1. Correia O, Duarte AF, Barros AM, et al. Multiple eccrine hidrocys- tomas—from diagnosis to treatment: the role of dermatoscopy and botulinum toxin. Dermatology. 2009;219:77-9. 2. Zaballos P, Bañuls J, Medina C, et al. Dermoscopy of apocrine hidrocystomas: a morphological study. J Eur Acad Dermatol Ve- nereol. 2014;28:378-81. 3. Alfaro-Castellón P, Mejía-Rodríguez SA, Valencia-Herrera A, et al. Dermoscopy distinction of eruptive vellus hair cysts with molluscum contagiosum and acne lesions. Pediatr Dermatol. 2012;29:772-3. 4. Lallas A, Moscarella E, Argenziano G, et al Dermoscopy of uncom- mon skin tumours. Australas J Dermatol. 2014;55:53-62. 5. Kamińska-Winciorek G, Spiewak R. Dermoscopy on nevus com- edonicus: a case report and review of the literature. Postepy Der- matol Alergol. 2013;30:252-4. 6. Zaballos P, Llambrich A, Puig S, et al. Dermoscopic findings of pilomatricomas. Dermatology. 2008; 217:225–30. 7. Altamura D, Menzies SW, Argenziano G, et al. Dermatoscopy of basal cell carcinoma: morphologic variability of global and local features and accuracy of diagnosis. J Am Acad Dermatol. 2010;62:67-75. mas and basal cell carcinomas [3,4]. Dermoscopy of vellus cysts exhibits well-demarcated round lesions characterized by light yellow-white center and erythematous halo with few irregular radiating capillaries in the periphery [3]. Der- moscopic features of comedonal acne include numerous light- and dark-brown homogenous areas with prominent keratin plugs [5]. Dermoscopy of eruptive syringomas exhibits yellowish-brownish structureless background and scarce fine linear vessels [4]. The most common dermoscopic features of pilomatricomas are irregular white and/or yellow structures, white streaks, reddish homogenous areas, linear vessels, ulceration and blue-gray areas [4,6]. Furthermore, the most common dermoscopic features of basal cell carcinomas are ulceration, multiple blue/gray globules, leaflike areas, large blue/gray ovoid nests, spoke-wheel areas, and arborizing telangiectasia [7]. In conclusion, characteristic dermoscopic features pre- sented herein can help differentiate eccrine hidrocystoma from other clinically similar lesions located on face.